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Database: PDB
Entry: 4UX8
LinkDB: 4UX8
Original site: 4UX8 
HEADER    SIGNALING PROTEIN                       19-AUG-14   4UX8              
TITLE     RET RECOGNITION OF GDNF-GFRALPHA1 LIGAND BY A COMPOSITE BINDING SITE  
TITLE    2 PROMOTES MEMBRANE-PROXIMAL SELF-ASSOCIATION                          
CAVEAT     4UX8    SER A 445 HAS WRONG CHIRALITY AT ATOM CA LEU A 452 HAS WRONG 
CAVEAT   2 4UX8    CHIRALITY AT ATOM CA GLN A 491 HAS WRONG CHIRALITY AT ATOM   
CAVEAT   3 4UX8    CA SER A 507 HAS WRONG CHIRALITY AT ATOM CA SER B 445 HAS    
CAVEAT   4 4UX8    WRONG CHIRALITY AT ATOM CA LEU B 452 HAS WRONG CHIRALITY AT  
CAVEAT   5 4UX8    ATOM CA GLN B 491 HAS WRONG CHIRALITY AT ATOM CA SER B 507   
CAVEAT   6 4UX8    HAS WRONG CHIRALITY AT ATOM CA SER A 445 C-ALPHA IS PLANAR   
CAVEAT   7 4UX8    LEU A 452 C-ALPHA IS PLANAR ALA A 458 C-ALPHA IS PLANAR GLN  
CAVEAT   8 4UX8    A 491 C-ALPHA IS PLANAR SER A 507 C-ALPHA IS PLANAR SER B    
CAVEAT   9 4UX8    445 C-ALPHA IS PLANAR LEU B 452 C-ALPHA IS PLANAR ALA B 458  
CAVEAT  10 4UX8    C-ALPHA IS PLANAR GLN B 491 C-ALPHA IS PLANAR SER B 507 C-   
CAVEAT  11 4UX8    ALPHA IS PLANAR                                              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET;       
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 FRAGMENT: RET EXTRACELLULAR DOMAIN, RESIDUES 29-635;                 
COMPND   5 SYNONYM: CADHERIN FAMILY MEMBER 12, PROTO-ONCOGENE C-RET, RET        
COMPND   6 RECEPTOR TYROSINE KINASE;                                            
COMPND   7 EC: 2.7.10.1;                                                        
COMPND   8 ENGINEERED: YES;                                                     
COMPND   9 MUTATION: YES;                                                       
COMPND  10 MOL_ID: 2;                                                           
COMPND  11 MOLECULE: GDNF FAMILY RECEPTOR ALPHA-1;                              
COMPND  12 CHAIN: C, E;                                                         
COMPND  13 SYNONYM: GFR ALPHA 1;                                                
COMPND  14 ENGINEERED: YES;                                                     
COMPND  15 MOL_ID: 3;                                                           
COMPND  16 MOLECULE: GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR;               
COMPND  17 CHAIN: D, F;                                                         
COMPND  18 FRAGMENT: MATURE, UNP RESIDUES 78-211;                               
COMPND  19 SYNONYM: HGDNF, ASTROCYTE-DERIVED TROPHIC FACTOR, ATF, GDNF;         
COMPND  20 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: CRICETULUS GRISEUS;                               
SOURCE   6 EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER;                           
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 10029;                                      
SOURCE   8 EXPRESSION_SYSTEM_CELL_LINE: CHO LEC8;                               
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE  11 ORGANISM_COMMON: NORWAY RAT;                                         
SOURCE  12 ORGANISM_TAXID: 10116;                                               
SOURCE  13 EXPRESSION_SYSTEM: CRICETULUS GRISEUS;                               
SOURCE  14 EXPRESSION_SYSTEM_COMMON: CHINESE HAMSTER;                           
SOURCE  15 EXPRESSION_SYSTEM_TAXID: 10029;                                      
SOURCE  16 EXPRESSION_SYSTEM_CELL_LINE: CHO LEC8;                               
SOURCE  17 MOL_ID: 3;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  22 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    SIGNALING PROTEIN, VERTEBRATE DEVELOPMENT, HUMAN DISEASES, PART OF    
KEYWDS   2 THE RET-GFL- GFRA COMPLEX                                            
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    K.GOODMAN,S.KJAER,F.BEURON,P.KNOWLES,A.NAWROTEK,E.BURNS,A.PURKISS,    
AUTHOR   2 R.GEORGE,M.SANTORO,E.P.MORRIS,N.Q.MCDONALD                           
REVDAT   5   29-JUL-20 4UX8    1       CAVEAT COMPND REMARK HETNAM              
REVDAT   5 2                   1       LINK   SITE   ATOM                       
REVDAT   4   23-OCT-19 4UX8    1       LINK   CRYST1                            
REVDAT   3   23-AUG-17 4UX8    1       REMARK                                   
REVDAT   2   08-OCT-14 4UX8    1       JRNL                                     
REVDAT   1   01-OCT-14 4UX8    0                                                
JRNL        AUTH   K.M.GOODMAN,S.KJAER,F.BEURON,P.P.KNOWLES,A.NAWROTEK,         
JRNL        AUTH 2 E.M.BURNS,A.G.PURKISS,R.GEORGE,M.SANTORO,E.P.MORRIS,         
JRNL        AUTH 3 N.Q.MCDONALD                                                 
JRNL        TITL   RET RECOGNITION OF GDNF-GFRALPHA1 LIGAND BY A COMPOSITE      
JRNL        TITL 2 BINDING SITE PROMOTES MEMBRANE-PROXIMAL SELF-ASSOCIATION.    
JRNL        REF    CELL REP.                     V.   8  1894 2014              
JRNL        REFN                   ESSN 2211-1247                               
JRNL        PMID   25242331                                                     
JRNL        DOI    10.1016/J.CELREP.2014.08.040                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.   24.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : CUSTOM, IMAGIC, SPIDER                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 24.00                          
REMARK   3   NUMBER OF PARTICLES               : 8519                           
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: SUBMISSION BASED ON EXPERIMENTAL DATA FROM EMDB EMD   
REMARK   3  -2712. (DEPOSITION ID: 12696).                                      
REMARK   4                                                                      
REMARK   4 4UX8 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE.                               
REMARK 100 THE DEPOSITION ID IS D_1290061275.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NEGATIVE STAIN                    
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : RECONSTITUTED MAMMALIAN RETECD    
REMARK 245                                    -GDNF-GFRA1 TERNARY COMPLEX       
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 08-NOV-12                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI F20                 
REMARK 245   DETECTOR TYPE                     : TVIPS TEMCAM-F415 (4K X 4K)    
REMARK 245   MINIMUM DEFOCUS (NM)              : 900.00                         
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : OTHER                          
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 100.00                         
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 80000                          
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     THR A   130                                                      
REMARK 465     SER A   131                                                      
REMARK 465     LEU A   132                                                      
REMARK 465     ARG A   133                                                      
REMARK 465     GLU A   134                                                      
REMARK 465     GLY A   135                                                      
REMARK 465     GLU A   136                                                      
REMARK 465     ALA A   247                                                      
REMARK 465     GLY A   248                                                      
REMARK 465     ALA A   249                                                      
REMARK 465     ASP A   380                                                      
REMARK 465     PHE A   381                                                      
REMARK 465     GLN A   382                                                      
REMARK 465     GLY A   383                                                      
REMARK 465     PRO A   384                                                      
REMARK 465     GLY A   385                                                      
REMARK 465     ALA A   386                                                      
REMARK 465     GLY A   387                                                      
REMARK 465     VAL A   388                                                      
REMARK 465     LEU A   389                                                      
REMARK 465     LEU A   390                                                      
REMARK 465     LEU A   391                                                      
REMARK 465     HIS A   392                                                      
REMARK 465     PHE A   393                                                      
REMARK 465     ASN A   394                                                      
REMARK 465     VAL A   395                                                      
REMARK 465     SER A   396                                                      
REMARK 465     VAL A   397                                                      
REMARK 465     LEU A   398                                                      
REMARK 465     PRO A   399                                                      
REMARK 465     VAL A   400                                                      
REMARK 465     SER A   401                                                      
REMARK 465     VAL A   509                                                      
REMARK 465     ALA A   510                                                      
REMARK 465     GLU A   511                                                      
REMARK 465     GLU A   512                                                      
REMARK 465     ALA A   513                                                      
REMARK 465     GLY A   514                                                      
REMARK 465     CYS A   515                                                      
REMARK 465     PRO A   516                                                      
REMARK 465     LEU A   517                                                      
REMARK 465     SER A   518                                                      
REMARK 465     CYS A   519                                                      
REMARK 465     ALA A   520                                                      
REMARK 465     VAL A   521                                                      
REMARK 465     SER A   522                                                      
REMARK 465     LYS A   523                                                      
REMARK 465     ARG A   524                                                      
REMARK 465     ARG A   525                                                      
REMARK 465     LEU A   526                                                      
REMARK 465     GLU A   527                                                      
REMARK 465     CYS A   528                                                      
REMARK 465     GLU A   529                                                      
REMARK 465     GLU A   530                                                      
REMARK 465     CYS A   531                                                      
REMARK 465     GLY A   532                                                      
REMARK 465     GLY A   533                                                      
REMARK 465     LEU A   534                                                      
REMARK 465     GLY A   535                                                      
REMARK 465     SER A   536                                                      
REMARK 465     PRO A   537                                                      
REMARK 465     THR A   538                                                      
REMARK 465     GLY A   539                                                      
REMARK 465     ARG A   540                                                      
REMARK 465     CYS A   541                                                      
REMARK 465     GLU A   542                                                      
REMARK 465     TRP A   543                                                      
REMARK 465     ARG A   544                                                      
REMARK 465     GLN A   545                                                      
REMARK 465     GLY A   546                                                      
REMARK 465     ASP A   547                                                      
REMARK 465     GLY A   548                                                      
REMARK 465     LYS A   549                                                      
REMARK 465     GLY A   550                                                      
REMARK 465     ILE A   551                                                      
REMARK 465     THR A   552                                                      
REMARK 465     ARG A   553                                                      
REMARK 465     ASN A   554                                                      
REMARK 465     PHE A   555                                                      
REMARK 465     SER A   556                                                      
REMARK 465     THR A   557                                                      
REMARK 465     CYS A   558                                                      
REMARK 465     SER A   559                                                      
REMARK 465     PRO A   560                                                      
REMARK 465     SER A   561                                                      
REMARK 465     THR A   562                                                      
REMARK 465     LYS A   563                                                      
REMARK 465     THR A   564                                                      
REMARK 465     CYS A   565                                                      
REMARK 465     PRO A   566                                                      
REMARK 465     ASP A   567                                                      
REMARK 465     GLY A   568                                                      
REMARK 465     HIS A   569                                                      
REMARK 465     CYS A   570                                                      
REMARK 465     ASP A   571                                                      
REMARK 465     VAL A   572                                                      
REMARK 465     VAL A   573                                                      
REMARK 465     GLU A   574                                                      
REMARK 465     THR A   575                                                      
REMARK 465     GLN A   576                                                      
REMARK 465     ASP A   577                                                      
REMARK 465     ILE A   578                                                      
REMARK 465     ASN A   579                                                      
REMARK 465     ILE A   580                                                      
REMARK 465     CYS A   581                                                      
REMARK 465     PRO A   582                                                      
REMARK 465     GLN A   583                                                      
REMARK 465     ASP A   584                                                      
REMARK 465     CYS A   585                                                      
REMARK 465     LEU A   586                                                      
REMARK 465     ARG A   587                                                      
REMARK 465     GLY A   588                                                      
REMARK 465     SER A   589                                                      
REMARK 465     ILE A   590                                                      
REMARK 465     VAL A   591                                                      
REMARK 465     GLY A   592                                                      
REMARK 465     GLY A   593                                                      
REMARK 465     HIS A   594                                                      
REMARK 465     GLU A   595                                                      
REMARK 465     PRO A   596                                                      
REMARK 465     GLY A   597                                                      
REMARK 465     GLU A   598                                                      
REMARK 465     PRO A   599                                                      
REMARK 465     ARG A   600                                                      
REMARK 465     GLY A   601                                                      
REMARK 465     ILE A   602                                                      
REMARK 465     LYS A   603                                                      
REMARK 465     ALA A   604                                                      
REMARK 465     GLY A   605                                                      
REMARK 465     TYR A   606                                                      
REMARK 465     GLY A   607                                                      
REMARK 465     THR A   608                                                      
REMARK 465     CYS A   609                                                      
REMARK 465     ASN A   610                                                      
REMARK 465     CYS A   611                                                      
REMARK 465     PHE A   612                                                      
REMARK 465     PRO A   613                                                      
REMARK 465     GLU A   614                                                      
REMARK 465     GLU A   615                                                      
REMARK 465     GLU A   616                                                      
REMARK 465     LYS A   617                                                      
REMARK 465     CYS A   618                                                      
REMARK 465     PHE A   619                                                      
REMARK 465     CYS A   620                                                      
REMARK 465     GLU A   621                                                      
REMARK 465     PRO A   622                                                      
REMARK 465     GLU A   623                                                      
REMARK 465     ASP A   624                                                      
REMARK 465     ILE A   625                                                      
REMARK 465     GLN A   626                                                      
REMARK 465     ASP A   627                                                      
REMARK 465     PRO A   628                                                      
REMARK 465     LEU A   629                                                      
REMARK 465     CYS A   630                                                      
REMARK 465     ASP A   631                                                      
REMARK 465     GLU A   632                                                      
REMARK 465     LEU A   633                                                      
REMARK 465     CYS A   634                                                      
REMARK 465     ARG A   635                                                      
REMARK 465     THR B   130                                                      
REMARK 465     SER B   131                                                      
REMARK 465     LEU B   132                                                      
REMARK 465     ARG B   133                                                      
REMARK 465     GLU B   134                                                      
REMARK 465     GLY B   135                                                      
REMARK 465     GLU B   136                                                      
REMARK 465     ALA B   247                                                      
REMARK 465     GLY B   248                                                      
REMARK 465     ALA B   249                                                      
REMARK 465     ASP B   380                                                      
REMARK 465     PHE B   381                                                      
REMARK 465     GLN B   382                                                      
REMARK 465     GLY B   383                                                      
REMARK 465     PRO B   384                                                      
REMARK 465     GLY B   385                                                      
REMARK 465     ALA B   386                                                      
REMARK 465     GLY B   387                                                      
REMARK 465     VAL B   388                                                      
REMARK 465     LEU B   389                                                      
REMARK 465     LEU B   390                                                      
REMARK 465     LEU B   391                                                      
REMARK 465     HIS B   392                                                      
REMARK 465     PHE B   393                                                      
REMARK 465     ASN B   394                                                      
REMARK 465     VAL B   395                                                      
REMARK 465     SER B   396                                                      
REMARK 465     VAL B   397                                                      
REMARK 465     LEU B   398                                                      
REMARK 465     PRO B   399                                                      
REMARK 465     VAL B   400                                                      
REMARK 465     SER B   401                                                      
REMARK 465     VAL B   509                                                      
REMARK 465     ALA B   510                                                      
REMARK 465     GLU B   511                                                      
REMARK 465     GLU B   512                                                      
REMARK 465     ALA B   513                                                      
REMARK 465     GLY B   514                                                      
REMARK 465     CYS B   515                                                      
REMARK 465     PRO B   516                                                      
REMARK 465     LEU B   517                                                      
REMARK 465     SER B   518                                                      
REMARK 465     CYS B   519                                                      
REMARK 465     ALA B   520                                                      
REMARK 465     VAL B   521                                                      
REMARK 465     SER B   522                                                      
REMARK 465     LYS B   523                                                      
REMARK 465     ARG B   524                                                      
REMARK 465     ARG B   525                                                      
REMARK 465     LEU B   526                                                      
REMARK 465     GLU B   527                                                      
REMARK 465     CYS B   528                                                      
REMARK 465     GLU B   529                                                      
REMARK 465     GLU B   530                                                      
REMARK 465     CYS B   531                                                      
REMARK 465     GLY B   532                                                      
REMARK 465     GLY B   533                                                      
REMARK 465     LEU B   534                                                      
REMARK 465     GLY B   535                                                      
REMARK 465     SER B   536                                                      
REMARK 465     PRO B   537                                                      
REMARK 465     THR B   538                                                      
REMARK 465     GLY B   539                                                      
REMARK 465     ARG B   540                                                      
REMARK 465     CYS B   541                                                      
REMARK 465     GLU B   542                                                      
REMARK 465     TRP B   543                                                      
REMARK 465     ARG B   544                                                      
REMARK 465     GLN B   545                                                      
REMARK 465     GLY B   546                                                      
REMARK 465     ASP B   547                                                      
REMARK 465     GLY B   548                                                      
REMARK 465     LYS B   549                                                      
REMARK 465     GLY B   550                                                      
REMARK 465     ILE B   551                                                      
REMARK 465     THR B   552                                                      
REMARK 465     ARG B   553                                                      
REMARK 465     ASN B   554                                                      
REMARK 465     PHE B   555                                                      
REMARK 465     SER B   556                                                      
REMARK 465     THR B   557                                                      
REMARK 465     CYS B   558                                                      
REMARK 465     SER B   559                                                      
REMARK 465     PRO B   560                                                      
REMARK 465     SER B   561                                                      
REMARK 465     THR B   562                                                      
REMARK 465     LYS B   563                                                      
REMARK 465     THR B   564                                                      
REMARK 465     CYS B   565                                                      
REMARK 465     PRO B   566                                                      
REMARK 465     ASP B   567                                                      
REMARK 465     GLY B   568                                                      
REMARK 465     HIS B   569                                                      
REMARK 465     CYS B   570                                                      
REMARK 465     ASP B   571                                                      
REMARK 465     VAL B   572                                                      
REMARK 465     VAL B   573                                                      
REMARK 465     GLU B   574                                                      
REMARK 465     THR B   575                                                      
REMARK 465     GLN B   576                                                      
REMARK 465     ASP B   577                                                      
REMARK 465     ILE B   578                                                      
REMARK 465     ASN B   579                                                      
REMARK 465     ILE B   580                                                      
REMARK 465     CYS B   581                                                      
REMARK 465     PRO B   582                                                      
REMARK 465     GLN B   583                                                      
REMARK 465     ASP B   584                                                      
REMARK 465     CYS B   585                                                      
REMARK 465     LEU B   586                                                      
REMARK 465     ARG B   587                                                      
REMARK 465     GLY B   588                                                      
REMARK 465     SER B   589                                                      
REMARK 465     ILE B   590                                                      
REMARK 465     VAL B   591                                                      
REMARK 465     GLY B   592                                                      
REMARK 465     GLY B   593                                                      
REMARK 465     HIS B   594                                                      
REMARK 465     GLU B   595                                                      
REMARK 465     PRO B   596                                                      
REMARK 465     GLY B   597                                                      
REMARK 465     GLU B   598                                                      
REMARK 465     PRO B   599                                                      
REMARK 465     ARG B   600                                                      
REMARK 465     GLY B   601                                                      
REMARK 465     ILE B   602                                                      
REMARK 465     LYS B   603                                                      
REMARK 465     ALA B   604                                                      
REMARK 465     GLY B   605                                                      
REMARK 465     TYR B   606                                                      
REMARK 465     GLY B   607                                                      
REMARK 465     THR B   608                                                      
REMARK 465     CYS B   609                                                      
REMARK 465     ASN B   610                                                      
REMARK 465     CYS B   611                                                      
REMARK 465     PHE B   612                                                      
REMARK 465     PRO B   613                                                      
REMARK 465     GLU B   614                                                      
REMARK 465     GLU B   615                                                      
REMARK 465     GLU B   616                                                      
REMARK 465     LYS B   617                                                      
REMARK 465     CYS B   618                                                      
REMARK 465     PHE B   619                                                      
REMARK 465     CYS B   620                                                      
REMARK 465     GLU B   621                                                      
REMARK 465     PRO B   622                                                      
REMARK 465     GLU B   623                                                      
REMARK 465     ASP B   624                                                      
REMARK 465     ILE B   625                                                      
REMARK 465     GLN B   626                                                      
REMARK 465     ASP B   627                                                      
REMARK 465     PRO B   628                                                      
REMARK 465     LEU B   629                                                      
REMARK 465     CYS B   630                                                      
REMARK 465     ASP B   631                                                      
REMARK 465     GLU B   632                                                      
REMARK 465     LEU B   633                                                      
REMARK 465     CYS B   634                                                      
REMARK 465     ARG B   635                                                      
REMARK 465     MET C   -18                                                      
REMARK 465     PHE C   -17                                                      
REMARK 465     LEU C   -16                                                      
REMARK 465     ALA C   -15                                                      
REMARK 465     THR C   -14                                                      
REMARK 465     LEU C   -13                                                      
REMARK 465     TYR C   -12                                                      
REMARK 465     PHE C   -11                                                      
REMARK 465     ALA C   -10                                                      
REMARK 465     LEU C    -9                                                      
REMARK 465     PRO C    -8                                                      
REMARK 465     LEU C    -7                                                      
REMARK 465     LEU C    -6                                                      
REMARK 465     ASP C    -5                                                      
REMARK 465     LEU C    -4                                                      
REMARK 465     LEU C    -3                                                      
REMARK 465     MET C    -2                                                      
REMARK 465     SER C    -1                                                      
REMARK 465     ALA C     0                                                      
REMARK 465     GLU C     1                                                      
REMARK 465     VAL C     2                                                      
REMARK 465     SER C     3                                                      
REMARK 465     GLY C     4                                                      
REMARK 465     GLY C     5                                                      
REMARK 465     LEU C    91                                                      
REMARK 465     GLN C    92                                                      
REMARK 465     GLY C    93                                                      
REMARK 465     ASN C    94                                                      
REMARK 465     ASP C    95                                                      
REMARK 465     LEU C    96                                                      
REMARK 465     LEU C    97                                                      
REMARK 465     GLU C    98                                                      
REMARK 465     ASP C    99                                                      
REMARK 465     SER C   100                                                      
REMARK 465     PRO C   101                                                      
REMARK 465     TYR C   102                                                      
REMARK 465     GLU C   103                                                      
REMARK 465     PRO C   104                                                      
REMARK 465     VAL C   105                                                      
REMARK 465     ASN C   106                                                      
REMARK 465     SER C   107                                                      
REMARK 465     ARG C   108                                                      
REMARK 465     LEU C   109                                                      
REMARK 465     SER C   110                                                      
REMARK 465     ASP C   111                                                      
REMARK 465     ILE C   112                                                      
REMARK 465     PHE C   113                                                      
REMARK 465     ARG C   114                                                      
REMARK 465     ALA C   115                                                      
REMARK 465     VAL C   116                                                      
REMARK 465     PRO C   117                                                      
REMARK 465     PHE C   118                                                      
REMARK 465     ILE C   119                                                      
REMARK 465     SER C   120                                                      
REMARK 465     VAL C   121                                                      
REMARK 465     GLU C   122                                                      
REMARK 465     HIS C   123                                                      
REMARK 465     ILE C   124                                                      
REMARK 465     SER C   125                                                      
REMARK 465     SER C   349                                                      
REMARK 465     ASP C   350                                                      
REMARK 465     VAL C   351                                                      
REMARK 465     THR C   352                                                      
REMARK 465     MET C   353                                                      
REMARK 465     TRP C   354                                                      
REMARK 465     GLN C   355                                                      
REMARK 465     PRO C   356                                                      
REMARK 465     ALA C   357                                                      
REMARK 465     PRO C   358                                                      
REMARK 465     PRO C   359                                                      
REMARK 465     VAL C   360                                                      
REMARK 465     GLN C   361                                                      
REMARK 465     THR C   362                                                      
REMARK 465     THR C   363                                                      
REMARK 465     THR C   364                                                      
REMARK 465     ALA C   365                                                      
REMARK 465     THR C   366                                                      
REMARK 465     THR C   367                                                      
REMARK 465     THR C   368                                                      
REMARK 465     THR C   369                                                      
REMARK 465     ALA C   370                                                      
REMARK 465     PHE C   371                                                      
REMARK 465     ARG C   372                                                      
REMARK 465     VAL C   373                                                      
REMARK 465     LYS C   374                                                      
REMARK 465     ASN C   375                                                      
REMARK 465     LYS C   376                                                      
REMARK 465     PRO C   377                                                      
REMARK 465     LEU C   378                                                      
REMARK 465     GLY C   379                                                      
REMARK 465     PRO C   380                                                      
REMARK 465     ALA C   381                                                      
REMARK 465     GLY C   382                                                      
REMARK 465     SER C   383                                                      
REMARK 465     GLU C   384                                                      
REMARK 465     ASN C   385                                                      
REMARK 465     GLU C   386                                                      
REMARK 465     ILE C   387                                                      
REMARK 465     PRO C   388                                                      
REMARK 465     THR C   389                                                      
REMARK 465     HIS C   390                                                      
REMARK 465     VAL C   391                                                      
REMARK 465     LEU C   392                                                      
REMARK 465     PRO C   393                                                      
REMARK 465     PRO C   394                                                      
REMARK 465     CYS C   395                                                      
REMARK 465     ALA C   396                                                      
REMARK 465     ASN C   397                                                      
REMARK 465     LEU C   398                                                      
REMARK 465     GLN C   399                                                      
REMARK 465     ALA C   400                                                      
REMARK 465     GLN C   401                                                      
REMARK 465     LYS C   402                                                      
REMARK 465     LEU C   403                                                      
REMARK 465     LYS C   404                                                      
REMARK 465     SER C   405                                                      
REMARK 465     ASN C   406                                                      
REMARK 465     VAL C   407                                                      
REMARK 465     SER C   408                                                      
REMARK 465     GLY C   409                                                      
REMARK 465     SER C   410                                                      
REMARK 465     THR C   411                                                      
REMARK 465     HIS C   412                                                      
REMARK 465     LEU C   413                                                      
REMARK 465     CYS C   414                                                      
REMARK 465     LEU C   415                                                      
REMARK 465     SER C   416                                                      
REMARK 465     ASP C   417                                                      
REMARK 465     SER C   418                                                      
REMARK 465     ASP C   419                                                      
REMARK 465     PHE C   420                                                      
REMARK 465     GLY C   421                                                      
REMARK 465     LYS C   422                                                      
REMARK 465     ASP C   423                                                      
REMARK 465     GLY C   424                                                      
REMARK 465     LEU C   425                                                      
REMARK 465     ALA C   426                                                      
REMARK 465     GLY C   427                                                      
REMARK 465     ALA C   428                                                      
REMARK 465     SER C   429                                                      
REMARK 465     SER C   430                                                      
REMARK 465     HIS C   431                                                      
REMARK 465     ILE C   432                                                      
REMARK 465     THR C   433                                                      
REMARK 465     THR C   434                                                      
REMARK 465     LYS C   435                                                      
REMARK 465     SER C   436                                                      
REMARK 465     MET C   437                                                      
REMARK 465     ALA C   438                                                      
REMARK 465     ALA C   439                                                      
REMARK 465     PRO C   440                                                      
REMARK 465     PRO C   441                                                      
REMARK 465     SER C   442                                                      
REMARK 465     CYS C   443                                                      
REMARK 465     SER C   444                                                      
REMARK 465     LEU C   445                                                      
REMARK 465     SER C   446                                                      
REMARK 465     SER C   447                                                      
REMARK 465     LEU C   448                                                      
REMARK 465     PRO C   449                                                      
REMARK 465     VAL C   450                                                      
REMARK 465     LEU C   451                                                      
REMARK 465     MET C   452                                                      
REMARK 465     LEU C   453                                                      
REMARK 465     THR C   454                                                      
REMARK 465     ALA C   455                                                      
REMARK 465     LEU C   456                                                      
REMARK 465     ALA C   457                                                      
REMARK 465     ALA C   458                                                      
REMARK 465     LEU C   459                                                      
REMARK 465     LEU C   460                                                      
REMARK 465     SER C   461                                                      
REMARK 465     VAL C   462                                                      
REMARK 465     SER C   463                                                      
REMARK 465     LEU C   464                                                      
REMARK 465     ALA C   465                                                      
REMARK 465     GLU C   466                                                      
REMARK 465     THR C   467                                                      
REMARK 465     SER C   468                                                      
REMARK 465     SER D     1                                                      
REMARK 465     PRO D     2                                                      
REMARK 465     ASP D     3                                                      
REMARK 465     LYS D     4                                                      
REMARK 465     GLN D     5                                                      
REMARK 465     MET D     6                                                      
REMARK 465     ALA D     7                                                      
REMARK 465     VAL D     8                                                      
REMARK 465     LEU D     9                                                      
REMARK 465     PRO D    10                                                      
REMARK 465     ARG D    11                                                      
REMARK 465     ARG D    12                                                      
REMARK 465     GLU D    13                                                      
REMARK 465     ARG D    14                                                      
REMARK 465     ASN D    15                                                      
REMARK 465     ARG D    16                                                      
REMARK 465     GLN D    17                                                      
REMARK 465     ALA D    18                                                      
REMARK 465     ALA D    19                                                      
REMARK 465     ALA D    20                                                      
REMARK 465     ALA D    21                                                      
REMARK 465     ASN D    22                                                      
REMARK 465     PRO D    23                                                      
REMARK 465     GLU D    24                                                      
REMARK 465     ASN D    25                                                      
REMARK 465     SER D    26                                                      
REMARK 465     ARG D    27                                                      
REMARK 465     GLY D    28                                                      
REMARK 465     LYS D    29                                                      
REMARK 465     GLY D    30                                                      
REMARK 465     ARG D    31                                                      
REMARK 465     ARG D    32                                                      
REMARK 465     GLY D    33                                                      
REMARK 465     GLN D    34                                                      
REMARK 465     ARG D    35                                                      
REMARK 465     GLY D    36                                                      
REMARK 465     LYS D    37                                                      
REMARK 465     ASN D    38                                                      
REMARK 465     ARG D    39                                                      
REMARK 465     GLY D    40                                                      
REMARK 465     CYS D    41                                                      
REMARK 465     MET E   -18                                                      
REMARK 465     PHE E   -17                                                      
REMARK 465     LEU E   -16                                                      
REMARK 465     ALA E   -15                                                      
REMARK 465     THR E   -14                                                      
REMARK 465     LEU E   -13                                                      
REMARK 465     TYR E   -12                                                      
REMARK 465     PHE E   -11                                                      
REMARK 465     ALA E   -10                                                      
REMARK 465     LEU E    -9                                                      
REMARK 465     PRO E    -8                                                      
REMARK 465     LEU E    -7                                                      
REMARK 465     LEU E    -6                                                      
REMARK 465     ASP E    -5                                                      
REMARK 465     LEU E    -4                                                      
REMARK 465     LEU E    -3                                                      
REMARK 465     MET E    -2                                                      
REMARK 465     SER E    -1                                                      
REMARK 465     ALA E     0                                                      
REMARK 465     GLU E     1                                                      
REMARK 465     VAL E     2                                                      
REMARK 465     SER E     3                                                      
REMARK 465     GLY E     4                                                      
REMARK 465     GLY E     5                                                      
REMARK 465     LEU E    91                                                      
REMARK 465     GLN E    92                                                      
REMARK 465     GLY E    93                                                      
REMARK 465     ASN E    94                                                      
REMARK 465     ASP E    95                                                      
REMARK 465     LEU E    96                                                      
REMARK 465     LEU E    97                                                      
REMARK 465     GLU E    98                                                      
REMARK 465     ASP E    99                                                      
REMARK 465     SER E   100                                                      
REMARK 465     PRO E   101                                                      
REMARK 465     TYR E   102                                                      
REMARK 465     GLU E   103                                                      
REMARK 465     PRO E   104                                                      
REMARK 465     VAL E   105                                                      
REMARK 465     ASN E   106                                                      
REMARK 465     SER E   107                                                      
REMARK 465     ARG E   108                                                      
REMARK 465     LEU E   109                                                      
REMARK 465     SER E   110                                                      
REMARK 465     ASP E   111                                                      
REMARK 465     ILE E   112                                                      
REMARK 465     PHE E   113                                                      
REMARK 465     ARG E   114                                                      
REMARK 465     ALA E   115                                                      
REMARK 465     VAL E   116                                                      
REMARK 465     PRO E   117                                                      
REMARK 465     PHE E   118                                                      
REMARK 465     ILE E   119                                                      
REMARK 465     SER E   120                                                      
REMARK 465     VAL E   121                                                      
REMARK 465     GLU E   122                                                      
REMARK 465     HIS E   123                                                      
REMARK 465     ILE E   124                                                      
REMARK 465     SER E   125                                                      
REMARK 465     SER E   349                                                      
REMARK 465     ASP E   350                                                      
REMARK 465     VAL E   351                                                      
REMARK 465     THR E   352                                                      
REMARK 465     MET E   353                                                      
REMARK 465     TRP E   354                                                      
REMARK 465     GLN E   355                                                      
REMARK 465     PRO E   356                                                      
REMARK 465     ALA E   357                                                      
REMARK 465     PRO E   358                                                      
REMARK 465     PRO E   359                                                      
REMARK 465     VAL E   360                                                      
REMARK 465     GLN E   361                                                      
REMARK 465     THR E   362                                                      
REMARK 465     THR E   363                                                      
REMARK 465     THR E   364                                                      
REMARK 465     ALA E   365                                                      
REMARK 465     THR E   366                                                      
REMARK 465     THR E   367                                                      
REMARK 465     THR E   368                                                      
REMARK 465     THR E   369                                                      
REMARK 465     ALA E   370                                                      
REMARK 465     PHE E   371                                                      
REMARK 465     ARG E   372                                                      
REMARK 465     VAL E   373                                                      
REMARK 465     LYS E   374                                                      
REMARK 465     ASN E   375                                                      
REMARK 465     LYS E   376                                                      
REMARK 465     PRO E   377                                                      
REMARK 465     LEU E   378                                                      
REMARK 465     GLY E   379                                                      
REMARK 465     PRO E   380                                                      
REMARK 465     ALA E   381                                                      
REMARK 465     GLY E   382                                                      
REMARK 465     SER E   383                                                      
REMARK 465     GLU E   384                                                      
REMARK 465     ASN E   385                                                      
REMARK 465     GLU E   386                                                      
REMARK 465     ILE E   387                                                      
REMARK 465     PRO E   388                                                      
REMARK 465     THR E   389                                                      
REMARK 465     HIS E   390                                                      
REMARK 465     VAL E   391                                                      
REMARK 465     LEU E   392                                                      
REMARK 465     PRO E   393                                                      
REMARK 465     PRO E   394                                                      
REMARK 465     CYS E   395                                                      
REMARK 465     ALA E   396                                                      
REMARK 465     ASN E   397                                                      
REMARK 465     LEU E   398                                                      
REMARK 465     GLN E   399                                                      
REMARK 465     ALA E   400                                                      
REMARK 465     GLN E   401                                                      
REMARK 465     LYS E   402                                                      
REMARK 465     LEU E   403                                                      
REMARK 465     LYS E   404                                                      
REMARK 465     SER E   405                                                      
REMARK 465     ASN E   406                                                      
REMARK 465     VAL E   407                                                      
REMARK 465     SER E   408                                                      
REMARK 465     GLY E   409                                                      
REMARK 465     SER E   410                                                      
REMARK 465     THR E   411                                                      
REMARK 465     HIS E   412                                                      
REMARK 465     LEU E   413                                                      
REMARK 465     CYS E   414                                                      
REMARK 465     LEU E   415                                                      
REMARK 465     SER E   416                                                      
REMARK 465     ASP E   417                                                      
REMARK 465     SER E   418                                                      
REMARK 465     ASP E   419                                                      
REMARK 465     PHE E   420                                                      
REMARK 465     GLY E   421                                                      
REMARK 465     LYS E   422                                                      
REMARK 465     ASP E   423                                                      
REMARK 465     GLY E   424                                                      
REMARK 465     LEU E   425                                                      
REMARK 465     ALA E   426                                                      
REMARK 465     GLY E   427                                                      
REMARK 465     ALA E   428                                                      
REMARK 465     SER E   429                                                      
REMARK 465     SER E   430                                                      
REMARK 465     HIS E   431                                                      
REMARK 465     ILE E   432                                                      
REMARK 465     THR E   433                                                      
REMARK 465     THR E   434                                                      
REMARK 465     LYS E   435                                                      
REMARK 465     SER E   436                                                      
REMARK 465     MET E   437                                                      
REMARK 465     ALA E   438                                                      
REMARK 465     ALA E   439                                                      
REMARK 465     PRO E   440                                                      
REMARK 465     PRO E   441                                                      
REMARK 465     SER E   442                                                      
REMARK 465     CYS E   443                                                      
REMARK 465     SER E   444                                                      
REMARK 465     LEU E   445                                                      
REMARK 465     SER E   446                                                      
REMARK 465     SER E   447                                                      
REMARK 465     LEU E   448                                                      
REMARK 465     PRO E   449                                                      
REMARK 465     VAL E   450                                                      
REMARK 465     LEU E   451                                                      
REMARK 465     MET E   452                                                      
REMARK 465     LEU E   453                                                      
REMARK 465     THR E   454                                                      
REMARK 465     ALA E   455                                                      
REMARK 465     LEU E   456                                                      
REMARK 465     ALA E   457                                                      
REMARK 465     ALA E   458                                                      
REMARK 465     LEU E   459                                                      
REMARK 465     LEU E   460                                                      
REMARK 465     SER E   461                                                      
REMARK 465     VAL E   462                                                      
REMARK 465     SER E   463                                                      
REMARK 465     LEU E   464                                                      
REMARK 465     ALA E   465                                                      
REMARK 465     GLU E   466                                                      
REMARK 465     THR E   467                                                      
REMARK 465     SER E   468                                                      
REMARK 465     SER F     1                                                      
REMARK 465     PRO F     2                                                      
REMARK 465     ASP F     3                                                      
REMARK 465     LYS F     4                                                      
REMARK 465     GLN F     5                                                      
REMARK 465     MET F     6                                                      
REMARK 465     ALA F     7                                                      
REMARK 465     VAL F     8                                                      
REMARK 465     LEU F     9                                                      
REMARK 465     PRO F    10                                                      
REMARK 465     ARG F    11                                                      
REMARK 465     ARG F    12                                                      
REMARK 465     GLU F    13                                                      
REMARK 465     ARG F    14                                                      
REMARK 465     ASN F    15                                                      
REMARK 465     ARG F    16                                                      
REMARK 465     GLN F    17                                                      
REMARK 465     ALA F    18                                                      
REMARK 465     ALA F    19                                                      
REMARK 465     ALA F    20                                                      
REMARK 465     ALA F    21                                                      
REMARK 465     ASN F    22                                                      
REMARK 465     PRO F    23                                                      
REMARK 465     GLU F    24                                                      
REMARK 465     ASN F    25                                                      
REMARK 465     SER F    26                                                      
REMARK 465     ARG F    27                                                      
REMARK 465     GLY F    28                                                      
REMARK 465     LYS F    29                                                      
REMARK 465     GLY F    30                                                      
REMARK 465     ARG F    31                                                      
REMARK 465     ARG F    32                                                      
REMARK 465     GLY F    33                                                      
REMARK 465     GLN F    34                                                      
REMARK 465     ARG F    35                                                      
REMARK 465     GLY F    36                                                      
REMARK 465     LYS F    37                                                      
REMARK 465     ASN F    38                                                      
REMARK 465     ARG F    39                                                      
REMARK 465     GLY F    40                                                      
REMARK 465     CYS F    41                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU A  61    CG   CD   OE1  OE2                                  
REMARK 470     PRO A 129    CG   CD                                             
REMARK 470     LYS A 161    CG   CD   CE   NZ                                   
REMARK 470     GLU A 232    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 233    CG   CD   OE1  NE2                                  
REMARK 470     LYS A 236    CG   CD   CE   NZ                                   
REMARK 470     ARG A 250    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B  61    CG   CD   OE1  OE2                                  
REMARK 470     PRO B 129    CG   CD                                             
REMARK 470     LYS B 161    CG   CD   CE   NZ                                   
REMARK 470     GLU B 232    CG   CD   OE1  OE2                                  
REMARK 470     GLN B 233    CG   CD   OE1  NE2                                  
REMARK 470     LYS B 236    CG   CD   CE   NZ                                   
REMARK 470     ARG B 250    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR C  44    OG1  CG2                                            
REMARK 470     LYS C 150    CG   CD   CE   NZ                                   
REMARK 470     GLU C 185    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 239    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 270    CD   OE1  OE2                                       
REMARK 470     ARG C 272    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 279    CG   CD   CE   NZ                                   
REMARK 470     GLU C 280    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 339    CE   NZ                                             
REMARK 470     ARG D  90    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP D  95    CG   OD1  OD2                                       
REMARK 470     LYS D  96    CG   CD   CE   NZ                                   
REMARK 470     LYS D 125    CE   NZ                                             
REMARK 470     THR E  44    OG1  CG2                                            
REMARK 470     LYS E 150    CG   CD   CE   NZ                                   
REMARK 470     GLU E 185    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 239    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 270    CD   OE1  OE2                                       
REMARK 470     ARG E 272    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E 279    CG   CD   CE   NZ                                   
REMARK 470     GLU E 280    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 339    CE   NZ                                             
REMARK 470     ARG F  90    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP F  95    CG   OD1  OD2                                       
REMARK 470     LYS F  96    CG   CD   CE   NZ                                   
REMARK 470     LYS F 125    CE   NZ                                             
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    VAL A   485     OE1  GLN A   497              0.23            
REMARK 500   O    VAL B   485     OE1  GLN B   497              0.23            
REMARK 500   OH   TYR B    76     CB   SER E   271              0.59            
REMARK 500   OH   TYR A    76     CB   SER C   271              0.62            
REMARK 500   CG1  VAL B   427     NE2  GLN B   431              0.78            
REMARK 500   CG1  VAL A   427     NE2  GLN A   431              0.78            
REMARK 500   CZ   TYR B   483     CB   LEU B   500              0.84            
REMARK 500   CZ   TYR A   483     CB   LEU A   500              0.84            
REMARK 500   NH1  ARG E    69     CE1  TYR E   254              0.87            
REMARK 500   NZ   LYS E    71     CG1  ILE E   255              0.90            
REMARK 500   CG   GLU E    77     CA   TYR E   254              0.91            
REMARK 500   CE   LYS E    71     CG1  ILE E   255              0.99            
REMARK 500   CZ   TYR A    76     OG   SER C   271              1.01            
REMARK 500   CZ   TYR B    76     OG   SER E   271              1.01            
REMARK 500   OH   TYR A    76     CA   SER C   271              1.03            
REMARK 500   CE2  TYR B   408     CD2  LEU B   410              1.03            
REMARK 500   CE2  TYR A   408     CD2  LEU A   410              1.04            
REMARK 500   OH   TYR B    76     CA   SER E   271              1.04            
REMARK 500   CD   GLU E    77     N    TYR E   254              1.04            
REMARK 500   NH1  ARG A    77     OG   SER C    42              1.05            
REMARK 500   CD2  LEU E    81     NE   ARG E   257              1.05            
REMARK 500   O    VAL A   427     CG   GLN A   431              1.13            
REMARK 500   O    VAL B   427     CG   GLN B   431              1.14            
REMARK 500   CG   LYS C    78     NH2  ARG C   257              1.17            
REMARK 500   CG   GLU E    77     N    TYR E   254              1.18            
REMARK 500   CG   LEU E    81     CZ   ARG E   257              1.20            
REMARK 500   CD   GLU E    77     CA   TYR E   254              1.25            
REMARK 500   OE2  GLU E    77     O    ASN E   253              1.26            
REMARK 500   OH   TYR A   483     CD2  LEU A   500              1.29            
REMARK 500   OH   TYR B   483     CD2  LEU B   500              1.29            
REMARK 500   O    VAL A   427     CD   GLN A   431              1.29            
REMARK 500   O    VAL B   427     CD   GLN B   431              1.30            
REMARK 500   CA   LYS E    71     CE2  TYR E   254              1.30            
REMARK 500   C    VAL B   485     OE1  GLN B   497              1.32            
REMARK 500   C    VAL A   485     OE1  GLN A   497              1.32            
REMARK 500   CD2  LEU E    81     CZ   ARG E   257              1.33            
REMARK 500   CZ   TYR A   483     CG   LEU A   500              1.35            
REMARK 500   CZ   TYR B   483     CG   LEU B   500              1.35            
REMARK 500   CG   GLU E    77     CB   TYR E   254              1.35            
REMARK 500   O    VAL A   485     CD   GLN A   497              1.39            
REMARK 500   O    VAL B   485     CD   GLN B   497              1.39            
REMARK 500   OH   TYR B   408     CD1  ILE B   422              1.40            
REMARK 500   OH   TYR A   408     CD1  ILE A   422              1.40            
REMARK 500   CE2  TYR A   483     CD1  LEU A   500              1.40            
REMARK 500   CE2  TYR B   483     CD1  LEU B   500              1.40            
REMARK 500   OH   TYR B   483     CG   LEU B   500              1.41            
REMARK 500   CE1  TYR B   483     CB   LEU B   500              1.41            
REMARK 500   CE1  TYR A   483     CB   LEU A   500              1.41            
REMARK 500   OH   TYR A   483     CG   LEU A   500              1.41            
REMARK 500   CE2  TYR A   483     CG   LEU A   500              1.44            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     183 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    PHE A 147   CD1   PHE A 147   CE1     0.128                       
REMARK 500    GLU A 164   CG    GLU A 164   CD      0.097                       
REMARK 500    PHE A 174   CE1   PHE A 174   CZ      0.124                       
REMARK 500    ARG A 205   CG    ARG A 205   CD      0.155                       
REMARK 500    GLU A 251   CB    GLU A 251   CG     -0.148                       
REMARK 500    TYR A 263   C     ASP A 264   N       0.154                       
REMARK 500    ALA A 269   C     PRO A 270   N       0.305                       
REMARK 500    PRO A 405   CD    PRO A 405   N       0.221                       
REMARK 500    LEU A 410   N     LEU A 410   CA      0.301                       
REMARK 500    ARG A 415   N     ARG A 415   CA      0.195                       
REMARK 500    ALA A 416   N     ALA A 416   CA      0.124                       
REMARK 500    GLY A 423   CA    GLY A 423   C       0.120                       
REMARK 500    GLY A 446   N     GLY A 446   CA      0.099                       
REMARK 500    THR A 451   CA    THR A 451   C       0.390                       
REMARK 500    LEU A 452   N     LEU A 452   CA     -0.245                       
REMARK 500    GLY A 453   N     GLY A 453   CA      0.108                       
REMARK 500    THR A 456   N     THR A 456   CA      0.201                       
REMARK 500    ALA A 458   CA    ALA A 458   C      -0.176                       
REMARK 500    PHE A 466   N     PHE A 466   CA     -0.135                       
REMARK 500    ARG A 474   CA    ARG A 474   C      -0.211                       
REMARK 500    PRO A 476   CD    PRO A 476   N       0.132                       
REMARK 500    LYS A 477   CA    LYS A 477   C       0.192                       
REMARK 500    TYR A 483   CA    TYR A 483   C       0.187                       
REMARK 500    THR A 488   N     THR A 488   CA      0.170                       
REMARK 500    ASP A 489   CA    ASP A 489   C       0.163                       
REMARK 500    GLN A 490   N     GLN A 490   CA      0.168                       
REMARK 500    GLY A 506   CA    GLY A 506   C       0.098                       
REMARK 500    TYR A 508   N     TYR A 508   CA      0.134                       
REMARK 500    TYR A 508   CA    TYR A 508   C       0.172                       
REMARK 500    TYR B 122   CE2   TYR B 122   CD2     0.090                       
REMARK 500    PHE B 147   CD1   PHE B 147   CE1     0.128                       
REMARK 500    GLU B 164   CG    GLU B 164   CD      0.098                       
REMARK 500    PHE B 174   CE1   PHE B 174   CZ      0.124                       
REMARK 500    ARG B 205   CG    ARG B 205   CD      0.154                       
REMARK 500    GLU B 251   CB    GLU B 251   CG     -0.147                       
REMARK 500    TYR B 263   C     ASP B 264   N       0.153                       
REMARK 500    ALA B 269   C     PRO B 270   N       0.305                       
REMARK 500    PRO B 405   CD    PRO B 405   N       0.221                       
REMARK 500    LEU B 410   N     LEU B 410   CA      0.300                       
REMARK 500    ARG B 415   N     ARG B 415   CA      0.194                       
REMARK 500    ALA B 416   N     ALA B 416   CA      0.123                       
REMARK 500    GLY B 423   CA    GLY B 423   C       0.119                       
REMARK 500    GLY B 446   N     GLY B 446   CA      0.098                       
REMARK 500    THR B 451   CA    THR B 451   C       0.390                       
REMARK 500    LEU B 452   N     LEU B 452   CA     -0.246                       
REMARK 500    GLY B 453   N     GLY B 453   CA      0.109                       
REMARK 500    THR B 456   N     THR B 456   CA      0.202                       
REMARK 500    ALA B 458   CA    ALA B 458   C      -0.176                       
REMARK 500    GLY B 463   N     GLY B 463   CA      0.090                       
REMARK 500    PHE B 466   N     PHE B 466   CA     -0.136                       
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      60 BOND DEVIATIONS.                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ARG A 112   CG  -  CD  -  NE  ANGL. DEV. = -15.9 DEGREES          
REMARK 500    ARG A 112   CD  -  NE  -  CZ  ANGL. DEV. =  14.1 DEGREES          
REMARK 500    ARG A 112   NE  -  CZ  -  NH1 ANGL. DEV. = -13.6 DEGREES          
REMARK 500    ARG A 112   NE  -  CZ  -  NH2 ANGL. DEV. =   9.5 DEGREES          
REMARK 500    ARG A 144   NE  -  CZ  -  NH2 ANGL. DEV. =   3.8 DEGREES          
REMARK 500    ARG A 189   NE  -  CZ  -  NH1 ANGL. DEV. =   3.8 DEGREES          
REMARK 500    ARG A 189   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.1 DEGREES          
REMARK 500    ARG A 205   NE  -  CZ  -  NH1 ANGL. DEV. =   5.4 DEGREES          
REMARK 500    ARG A 205   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.5 DEGREES          
REMARK 500    ARG A 226   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.0 DEGREES          
REMARK 500    ASP A 230   CB  -  CG  -  OD1 ANGL. DEV. =   7.2 DEGREES          
REMARK 500    TYR A 263   CA  -  C   -  N   ANGL. DEV. =  41.9 DEGREES          
REMARK 500    TYR A 263   O   -  C   -  N   ANGL. DEV. = -44.5 DEGREES          
REMARK 500    ASP A 264   C   -  N   -  CA  ANGL. DEV. =  18.2 DEGREES          
REMARK 500    PRO A 270   C   -  N   -  CD  ANGL. DEV. = -34.7 DEGREES          
REMARK 500    GLU A 309   CB  -  CA  -  C   ANGL. DEV. = -16.2 DEGREES          
REMARK 500    HIS A 403   CB  -  CA  -  C   ANGL. DEV. =  18.6 DEGREES          
REMARK 500    PRO A 405   C   -  N   -  CA  ANGL. DEV. =  15.4 DEGREES          
REMARK 500    PRO A 405   CA  -  N   -  CD  ANGL. DEV. =  -9.2 DEGREES          
REMARK 500    PRO A 405   CB  -  CA  -  C   ANGL. DEV. = -23.7 DEGREES          
REMARK 500    SER A 409   CA  -  C   -  O   ANGL. DEV. = -13.6 DEGREES          
REMARK 500    SER A 409   CA  -  C   -  N   ANGL. DEV. =  14.1 DEGREES          
REMARK 500    LEU A 410   C   -  N   -  CA  ANGL. DEV. = -20.7 DEGREES          
REMARK 500    SER A 411   CB  -  CA  -  C   ANGL. DEV. = -14.9 DEGREES          
REMARK 500    ARG A 414   CB  -  CA  -  C   ANGL. DEV. = -18.8 DEGREES          
REMARK 500    ARG A 414   N   -  CA  -  C   ANGL. DEV. =  17.9 DEGREES          
REMARK 500    ARG A 415   C   -  N   -  CA  ANGL. DEV. = -21.3 DEGREES          
REMARK 500    ARG A 415   N   -  CA  -  CB  ANGL. DEV. = -13.6 DEGREES          
REMARK 500    ALA A 416   CB  -  CA  -  C   ANGL. DEV. =  -9.0 DEGREES          
REMARK 500    ALA A 416   N   -  CA  -  CB  ANGL. DEV. =  12.2 DEGREES          
REMARK 500    ARG A 418   CB  -  CA  -  C   ANGL. DEV. =  17.9 DEGREES          
REMARK 500    ALA A 420   CB  -  CA  -  C   ANGL. DEV. =  -9.7 DEGREES          
REMARK 500    ILE A 422   N   -  CA  -  C   ANGL. DEV. =  20.9 DEGREES          
REMARK 500    LYS A 424   CB  -  CA  -  C   ANGL. DEV. = -16.7 DEGREES          
REMARK 500    VAL A 427   CB  -  CA  -  C   ANGL. DEV. = -14.5 DEGREES          
REMARK 500    SER A 434   N   -  CA  -  CB  ANGL. DEV. =  24.6 DEGREES          
REMARK 500    GLY A 435   CA  -  C   -  O   ANGL. DEV. = -22.4 DEGREES          
REMARK 500    GLY A 435   CA  -  C   -  N   ANGL. DEV. =  21.4 DEGREES          
REMARK 500    ILE A 436   CB  -  CA  -  C   ANGL. DEV. = -17.2 DEGREES          
REMARK 500    ILE A 436   N   -  CA  -  CB  ANGL. DEV. = -17.3 DEGREES          
REMARK 500    ASN A 437   CB  -  CA  -  C   ANGL. DEV. = -15.8 DEGREES          
REMARK 500    VAL A 438   CB  -  CA  -  C   ANGL. DEV. = -11.5 DEGREES          
REMARK 500    LEU A 442   N   -  CA  -  CB  ANGL. DEV. =  12.2 DEGREES          
REMARK 500    SER A 445   CB  -  CA  -  C   ANGL. DEV. =  12.3 DEGREES          
REMARK 500    SER A 445   N   -  CA  -  C   ANGL. DEV. =  18.6 DEGREES          
REMARK 500    GLY A 446   C   -  N   -  CA  ANGL. DEV. = -13.4 DEGREES          
REMARK 500    ALA A 447   CB  -  CA  -  C   ANGL. DEV. = -33.5 DEGREES          
REMARK 500    ALA A 447   N   -  CA  -  CB  ANGL. DEV. =  -8.4 DEGREES          
REMARK 500    CYS A 449   CB  -  CA  -  C   ANGL. DEV. = -14.8 DEGREES          
REMARK 500    SER A 450   CB  -  CA  -  C   ANGL. DEV. = -42.8 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     187 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU A  50      -65.38   -105.60                                   
REMARK 500    GLU A 210      117.84    -31.90                                   
REMARK 500    ASP A 290       95.13   -162.06                                   
REMARK 500    ASP A 302      179.70    -58.20                                   
REMARK 500    ARG A 348      153.48    -49.26                                   
REMARK 500    ALA A 349       86.35    -33.54                                   
REMARK 500    VAL A 351     -175.98    133.47                                   
REMARK 500    HIS A 352      129.01    175.25                                   
REMARK 500    ASN A 359      124.75    -18.04                                   
REMARK 500    SER A 363     -146.93    -69.10                                   
REMARK 500    SER A 413       14.26     54.43                                   
REMARK 500    ARG A 414       85.05     -9.49                                   
REMARK 500    ALA A 416      129.39    126.84                                   
REMARK 500    ARG A 417      130.97     20.12                                   
REMARK 500    ARG A 418      -91.47    -34.61                                   
REMARK 500    GLN A 421       97.36    -49.38                                   
REMARK 500    SER A 434       61.45     64.04                                   
REMARK 500    SER A 444      155.72    146.68                                   
REMARK 500    SER A 445      -61.82      4.62                                   
REMARK 500    ASN A 448      -24.47     83.45                                   
REMARK 500    SER A 450      115.50     49.52                                   
REMARK 500    THR A 451      120.75     47.77                                   
REMARK 500    LEU A 452      -82.78    -70.67                                   
REMARK 500    ALA A 458       97.46    115.02                                   
REMARK 500    THR A 461       36.79    -50.68                                   
REMARK 500    ASN A 468     -159.85    -95.58                                   
REMARK 500    THR A 470       46.60    -78.36                                   
REMARK 500    LEU A 473      120.93     50.61                                   
REMARK 500    LYS A 477     -100.37    140.52                                   
REMARK 500    GLU A 480      138.70   -178.60                                   
REMARK 500    ASP A 489      -84.32    -27.76                                   
REMARK 500    GLN A 491      -51.21     88.88                                   
REMARK 500    SER A 507     -111.04     66.85                                   
REMARK 500    LEU B  50      -65.40   -105.63                                   
REMARK 500    GLU B 210      117.85    -31.88                                   
REMARK 500    ASP B 290       95.14   -162.06                                   
REMARK 500    ASP B 302      179.73    -58.13                                   
REMARK 500    ARG B 348      153.47    -49.23                                   
REMARK 500    ALA B 349       86.28    -33.48                                   
REMARK 500    VAL B 351     -175.93    133.52                                   
REMARK 500    HIS B 352      129.03    175.20                                   
REMARK 500    ASN B 359      124.78    -18.06                                   
REMARK 500    SER B 363     -146.94    -69.12                                   
REMARK 500    SER B 413       14.26     54.38                                   
REMARK 500    ARG B 414       85.05     -9.50                                   
REMARK 500    ALA B 416      129.36    126.92                                   
REMARK 500    ARG B 417      130.95     20.18                                   
REMARK 500    ARG B 418      -91.52    -34.54                                   
REMARK 500    GLN B 421       97.37    -49.43                                   
REMARK 500    SER B 434       61.46     64.07                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     101 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 TYR A  263     ASP A  264                 -126.00                    
REMARK 500 TYR B  263     ASP B  264                 -125.96                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    ARG A 112         0.10    SIDE CHAIN                              
REMARK 500    ARG B 112         0.10    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA A1603  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU A 178   OE2                                                    
REMARK 620 2 ASP A 264   OD1  96.6                                              
REMARK 620 3 ASP A 264   OD2  90.2  45.5                                        
REMARK 620 4 GLU A 265   O    90.6  60.8 105.8                                  
REMARK 620 5 ASP A 267   OD1  58.9 115.9 144.5  61.5                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA A1604  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU A 178   OE1                                                    
REMARK 620 2 ASP A 230   OD1  77.3                                              
REMARK 620 3 ASP A 267   OD2  67.1 108.9                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA A1605  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 266   OD1                                                    
REMARK 620 2 SER A 268   O    67.4                                              
REMARK 620 3 ASP A 300   OD2 164.7 102.8                                        
REMARK 620 4 ASP A 302   OD2 107.9  80.1  57.6                                  
REMARK 620 5 GLY A 308   O   126.3 159.4  66.7 106.3                            
REMARK 620 6 ARG A 360   NH1  63.5 112.8 131.8 156.9  68.8                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA B1603  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU B 178   OE2                                                    
REMARK 620 2 ASP B 264   OD2  90.3                                              
REMARK 620 3 ASP B 264   OD1  96.7  45.5                                        
REMARK 620 4 GLU B 265   O    90.6 105.8  60.8                                  
REMARK 620 5 ASP B 267   OD1  58.9 144.5 115.9  61.5                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA B1604  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU B 178   OE1                                                    
REMARK 620 2 ASP B 230   OD1  77.2                                              
REMARK 620 3 ASP B 267   OD2  67.1 108.9                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA B1605  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP B 266   OD1                                                    
REMARK 620 2 SER B 268   O    67.4                                              
REMARK 620 3 ASP B 300   OD2 164.7 102.8                                        
REMARK 620 4 ASP B 302   OD2 107.9  80.1  57.6                                  
REMARK 620 5 GLY B 308   O   126.3 159.4  66.7 106.3                            
REMARK 620 6 ARG B 360   NH1  63.5 112.8 131.8 156.8  68.7                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-2712   RELATED DB: EMDB                              
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 RESIDUES 509 TO 635 ARE NOT IN THE MODEL                             
DBREF  4UX8 A   29   635  UNP    P07949   RET_HUMAN       29    635             
DBREF  4UX8 B   29   635  UNP    P07949   RET_HUMAN       29    635             
DBREF  4UX8 C  -18   468  UNP    O35748   O35748_RAT       1    463             
DBREF  4UX8 D    1   134  UNP    P39905   GDNF_HUMAN      78    211             
DBREF  4UX8 E  -18   468  UNP    O35748   O35748_RAT       1    463             
DBREF  4UX8 F    1   134  UNP    P39905   GDNF_HUMAN      78    211             
SEQADV 4UX8 ARG A   87  UNP  P07949    CYS    87 ENGINEERED MUTATION            
SEQADV 4UX8 GLN A   98  UNP  P07949    ASN    98 CONFLICT                       
SEQADV 4UX8 GLN A  199  UNP  P07949    ASN   199 CONFLICT                       
SEQADV 4UX8 SER A  216  UNP  P07949    CYS   216 ENGINEERED MUTATION            
SEQADV 4UX8 ARG B   87  UNP  P07949    CYS    87 ENGINEERED MUTATION            
SEQADV 4UX8 GLN B   98  UNP  P07949    ASN    98 CONFLICT                       
SEQADV 4UX8 GLN B  199  UNP  P07949    ASN   199 CONFLICT                       
SEQADV 4UX8 SER B  216  UNP  P07949    CYS   216 ENGINEERED MUTATION            
SEQRES   1 A  607  LEU TYR PHE SER ARG ASP ALA TYR TRP GLU LYS LEU TYR          
SEQRES   2 A  607  VAL ASP GLN ALA ALA GLY THR PRO LEU LEU TYR VAL HIS          
SEQRES   3 A  607  ALA LEU ARG ASP ALA PRO GLU GLU VAL PRO SER PHE ARG          
SEQRES   4 A  607  LEU GLY GLN HIS LEU TYR GLY THR TYR ARG THR ARG LEU          
SEQRES   5 A  607  HIS GLU ASN ASN TRP ILE ARG ILE GLN GLU ASP THR GLY          
SEQRES   6 A  607  LEU LEU TYR LEU GLN ARG SER LEU ASP HIS SER SER TRP          
SEQRES   7 A  607  GLU LYS LEU SER VAL ARG ASN ARG GLY PHE PRO LEU LEU          
SEQRES   8 A  607  THR VAL TYR LEU LYS VAL PHE LEU SER PRO THR SER LEU          
SEQRES   9 A  607  ARG GLU GLY GLU CYS GLN TRP PRO GLY CYS ALA ARG VAL          
SEQRES  10 A  607  TYR PHE SER PHE PHE ASN THR SER PHE PRO ALA CYS SER          
SEQRES  11 A  607  SER LEU LYS PRO ARG GLU LEU CYS PHE PRO GLU THR ARG          
SEQRES  12 A  607  PRO SER PHE ARG ILE ARG GLU ASN ARG PRO PRO GLY THR          
SEQRES  13 A  607  PHE HIS GLN PHE ARG LEU LEU PRO VAL GLN PHE LEU CYS          
SEQRES  14 A  607  PRO GLN ILE SER VAL ALA TYR ARG LEU LEU GLU GLY GLU          
SEQRES  15 A  607  GLY LEU PRO PHE ARG SER ALA PRO ASP SER LEU GLU VAL          
SEQRES  16 A  607  SER THR ARG TRP ALA LEU ASP ARG GLU GLN ARG GLU LYS          
SEQRES  17 A  607  TYR GLU LEU VAL ALA VAL CYS THR VAL HIS ALA GLY ALA          
SEQRES  18 A  607  ARG GLU GLU VAL VAL MET VAL PRO PHE PRO VAL THR VAL          
SEQRES  19 A  607  TYR ASP GLU ASP ASP SER ALA PRO THR PHE PRO ALA GLY          
SEQRES  20 A  607  VAL ASP THR ALA SER ALA VAL VAL GLU PHE LYS ARG LYS          
SEQRES  21 A  607  GLU ASP THR VAL VAL ALA THR LEU ARG VAL PHE ASP ALA          
SEQRES  22 A  607  ASP VAL VAL PRO ALA SER GLY GLU LEU VAL ARG ARG TYR          
SEQRES  23 A  607  THR SER THR LEU LEU PRO GLY ASP THR TRP ALA GLN GLN          
SEQRES  24 A  607  THR PHE ARG VAL GLU HIS TRP PRO ASN GLU THR SER VAL          
SEQRES  25 A  607  GLN ALA ASN GLY SER PHE VAL ARG ALA THR VAL HIS ASP          
SEQRES  26 A  607  TYR ARG LEU VAL LEU ASN ARG ASN LEU SER ILE SER GLU          
SEQRES  27 A  607  ASN ARG THR MET GLN LEU ALA VAL LEU VAL ASN ASP SER          
SEQRES  28 A  607  ASP PHE GLN GLY PRO GLY ALA GLY VAL LEU LEU LEU HIS          
SEQRES  29 A  607  PHE ASN VAL SER VAL LEU PRO VAL SER LEU HIS LEU PRO          
SEQRES  30 A  607  SER THR TYR SER LEU SER VAL SER ARG ARG ALA ARG ARG          
SEQRES  31 A  607  PHE ALA GLN ILE GLY LYS VAL CYS VAL GLU ASN CYS GLN          
SEQRES  32 A  607  ALA PHE SER GLY ILE ASN VAL GLN TYR LYS LEU HIS SER          
SEQRES  33 A  607  SER GLY ALA ASN CYS SER THR LEU GLY VAL VAL THR SER          
SEQRES  34 A  607  ALA GLU ASP THR SER GLY ILE LEU PHE VAL ASN ASP THR          
SEQRES  35 A  607  LYS ALA LEU ARG ARG PRO LYS CYS ALA GLU LEU HIS TYR          
SEQRES  36 A  607  MET VAL VAL ALA THR ASP GLN GLN THR SER ARG GLN ALA          
SEQRES  37 A  607  GLN ALA GLN LEU LEU VAL THR VAL GLU GLY SER TYR VAL          
SEQRES  38 A  607  ALA GLU GLU ALA GLY CYS PRO LEU SER CYS ALA VAL SER          
SEQRES  39 A  607  LYS ARG ARG LEU GLU CYS GLU GLU CYS GLY GLY LEU GLY          
SEQRES  40 A  607  SER PRO THR GLY ARG CYS GLU TRP ARG GLN GLY ASP GLY          
SEQRES  41 A  607  LYS GLY ILE THR ARG ASN PHE SER THR CYS SER PRO SER          
SEQRES  42 A  607  THR LYS THR CYS PRO ASP GLY HIS CYS ASP VAL VAL GLU          
SEQRES  43 A  607  THR GLN ASP ILE ASN ILE CYS PRO GLN ASP CYS LEU ARG          
SEQRES  44 A  607  GLY SER ILE VAL GLY GLY HIS GLU PRO GLY GLU PRO ARG          
SEQRES  45 A  607  GLY ILE LYS ALA GLY TYR GLY THR CYS ASN CYS PHE PRO          
SEQRES  46 A  607  GLU GLU GLU LYS CYS PHE CYS GLU PRO GLU ASP ILE GLN          
SEQRES  47 A  607  ASP PRO LEU CYS ASP GLU LEU CYS ARG                          
SEQRES   1 B  607  LEU TYR PHE SER ARG ASP ALA TYR TRP GLU LYS LEU TYR          
SEQRES   2 B  607  VAL ASP GLN ALA ALA GLY THR PRO LEU LEU TYR VAL HIS          
SEQRES   3 B  607  ALA LEU ARG ASP ALA PRO GLU GLU VAL PRO SER PHE ARG          
SEQRES   4 B  607  LEU GLY GLN HIS LEU TYR GLY THR TYR ARG THR ARG LEU          
SEQRES   5 B  607  HIS GLU ASN ASN TRP ILE ARG ILE GLN GLU ASP THR GLY          
SEQRES   6 B  607  LEU LEU TYR LEU GLN ARG SER LEU ASP HIS SER SER TRP          
SEQRES   7 B  607  GLU LYS LEU SER VAL ARG ASN ARG GLY PHE PRO LEU LEU          
SEQRES   8 B  607  THR VAL TYR LEU LYS VAL PHE LEU SER PRO THR SER LEU          
SEQRES   9 B  607  ARG GLU GLY GLU CYS GLN TRP PRO GLY CYS ALA ARG VAL          
SEQRES  10 B  607  TYR PHE SER PHE PHE ASN THR SER PHE PRO ALA CYS SER          
SEQRES  11 B  607  SER LEU LYS PRO ARG GLU LEU CYS PHE PRO GLU THR ARG          
SEQRES  12 B  607  PRO SER PHE ARG ILE ARG GLU ASN ARG PRO PRO GLY THR          
SEQRES  13 B  607  PHE HIS GLN PHE ARG LEU LEU PRO VAL GLN PHE LEU CYS          
SEQRES  14 B  607  PRO GLN ILE SER VAL ALA TYR ARG LEU LEU GLU GLY GLU          
SEQRES  15 B  607  GLY LEU PRO PHE ARG SER ALA PRO ASP SER LEU GLU VAL          
SEQRES  16 B  607  SER THR ARG TRP ALA LEU ASP ARG GLU GLN ARG GLU LYS          
SEQRES  17 B  607  TYR GLU LEU VAL ALA VAL CYS THR VAL HIS ALA GLY ALA          
SEQRES  18 B  607  ARG GLU GLU VAL VAL MET VAL PRO PHE PRO VAL THR VAL          
SEQRES  19 B  607  TYR ASP GLU ASP ASP SER ALA PRO THR PHE PRO ALA GLY          
SEQRES  20 B  607  VAL ASP THR ALA SER ALA VAL VAL GLU PHE LYS ARG LYS          
SEQRES  21 B  607  GLU ASP THR VAL VAL ALA THR LEU ARG VAL PHE ASP ALA          
SEQRES  22 B  607  ASP VAL VAL PRO ALA SER GLY GLU LEU VAL ARG ARG TYR          
SEQRES  23 B  607  THR SER THR LEU LEU PRO GLY ASP THR TRP ALA GLN GLN          
SEQRES  24 B  607  THR PHE ARG VAL GLU HIS TRP PRO ASN GLU THR SER VAL          
SEQRES  25 B  607  GLN ALA ASN GLY SER PHE VAL ARG ALA THR VAL HIS ASP          
SEQRES  26 B  607  TYR ARG LEU VAL LEU ASN ARG ASN LEU SER ILE SER GLU          
SEQRES  27 B  607  ASN ARG THR MET GLN LEU ALA VAL LEU VAL ASN ASP SER          
SEQRES  28 B  607  ASP PHE GLN GLY PRO GLY ALA GLY VAL LEU LEU LEU HIS          
SEQRES  29 B  607  PHE ASN VAL SER VAL LEU PRO VAL SER LEU HIS LEU PRO          
SEQRES  30 B  607  SER THR TYR SER LEU SER VAL SER ARG ARG ALA ARG ARG          
SEQRES  31 B  607  PHE ALA GLN ILE GLY LYS VAL CYS VAL GLU ASN CYS GLN          
SEQRES  32 B  607  ALA PHE SER GLY ILE ASN VAL GLN TYR LYS LEU HIS SER          
SEQRES  33 B  607  SER GLY ALA ASN CYS SER THR LEU GLY VAL VAL THR SER          
SEQRES  34 B  607  ALA GLU ASP THR SER GLY ILE LEU PHE VAL ASN ASP THR          
SEQRES  35 B  607  LYS ALA LEU ARG ARG PRO LYS CYS ALA GLU LEU HIS TYR          
SEQRES  36 B  607  MET VAL VAL ALA THR ASP GLN GLN THR SER ARG GLN ALA          
SEQRES  37 B  607  GLN ALA GLN LEU LEU VAL THR VAL GLU GLY SER TYR VAL          
SEQRES  38 B  607  ALA GLU GLU ALA GLY CYS PRO LEU SER CYS ALA VAL SER          
SEQRES  39 B  607  LYS ARG ARG LEU GLU CYS GLU GLU CYS GLY GLY LEU GLY          
SEQRES  40 B  607  SER PRO THR GLY ARG CYS GLU TRP ARG GLN GLY ASP GLY          
SEQRES  41 B  607  LYS GLY ILE THR ARG ASN PHE SER THR CYS SER PRO SER          
SEQRES  42 B  607  THR LYS THR CYS PRO ASP GLY HIS CYS ASP VAL VAL GLU          
SEQRES  43 B  607  THR GLN ASP ILE ASN ILE CYS PRO GLN ASP CYS LEU ARG          
SEQRES  44 B  607  GLY SER ILE VAL GLY GLY HIS GLU PRO GLY GLU PRO ARG          
SEQRES  45 B  607  GLY ILE LYS ALA GLY TYR GLY THR CYS ASN CYS PHE PRO          
SEQRES  46 B  607  GLU GLU GLU LYS CYS PHE CYS GLU PRO GLU ASP ILE GLN          
SEQRES  47 B  607  ASP PRO LEU CYS ASP GLU LEU CYS ARG                          
SEQRES   1 C  463  MET PHE LEU ALA THR LEU TYR PHE ALA LEU PRO LEU LEU          
SEQRES   2 C  463  ASP LEU LEU MET SER ALA GLU VAL SER GLY GLY ASP ARG          
SEQRES   3 C  463  LEU ASP CYS VAL LYS ALA SER ASP GLN CYS LEU LYS GLU          
SEQRES   4 C  463  GLN SER CYS SER THR LYS TYR ARG THR LEU ARG GLN CYS          
SEQRES   5 C  463  VAL ALA GLY LYS GLU THR ASN PHE SER LEU THR SER GLY          
SEQRES   6 C  463  LEU GLU ALA LYS ASP GLU CYS ARG SER ALA MET GLU ALA          
SEQRES   7 C  463  LEU LYS GLN LYS SER LEU TYR ASN CYS ARG CYS LYS ARG          
SEQRES   8 C  463  GLY MET LYS LYS GLU LYS ASN CYS LEU ARG ILE TYR TRP          
SEQRES   9 C  463  SER MET TYR GLN SER LEU GLN GLY ASN ASP LEU LEU GLU          
SEQRES  10 C  463  ASP SER PRO TYR GLU PRO VAL ASN SER ARG LEU SER ASP          
SEQRES  11 C  463  ILE PHE ARG ALA VAL PRO PHE ILE SER VAL GLU HIS ILE          
SEQRES  12 C  463  SER LYS GLY ASN ASN CYS LEU ASP ALA ALA LYS ALA CYS          
SEQRES  13 C  463  ASN LEU ASP ASP THR CYS LYS LYS TYR ARG SER ALA TYR          
SEQRES  14 C  463  ILE THR PRO CYS THR THR SER MET SER ASN GLU VAL CYS          
SEQRES  15 C  463  ASN ARG ARG LYS CYS HIS LYS ALA LEU ARG GLN PHE PHE          
SEQRES  16 C  463  ASP LYS VAL PRO ALA LYS HIS SER TYR GLY MET LEU PHE          
SEQRES  17 C  463  CYS SER CYS ARG ASP ILE ALA CYS THR GLU ARG ARG ARG          
SEQRES  18 C  463  GLN THR ILE VAL PRO VAL CYS SER TYR GLU GLU ARG GLU          
SEQRES  19 C  463  ARG PRO ASN CYS LEU SER LEU GLN ASP SER CYS LYS THR          
SEQRES  20 C  463  ASN TYR ILE CYS ARG SER ARG LEU ALA ASP PHE PHE THR          
SEQRES  21 C  463  ASN CYS GLN PRO GLU SER ARG SER VAL SER ASN CYS LEU          
SEQRES  22 C  463  LYS GLU ASN TYR ALA ASP CYS LEU LEU ALA TYR SER GLY          
SEQRES  23 C  463  LEU ILE GLY THR VAL MET THR PRO ASN TYR VAL ASP SER          
SEQRES  24 C  463  SER SER LEU SER VAL ALA PRO TRP CYS ASP CYS SER ASN          
SEQRES  25 C  463  SER GLY ASN ASP LEU GLU ASP CYS LEU LYS PHE LEU ASN          
SEQRES  26 C  463  PHE PHE LYS ASP ASN THR CYS LEU LYS ASN ALA ILE GLN          
SEQRES  27 C  463  ALA PHE GLY ASN GLY SER ASP VAL THR MET TRP GLN PRO          
SEQRES  28 C  463  ALA PRO PRO VAL GLN THR THR THR ALA THR THR THR THR          
SEQRES  29 C  463  ALA PHE ARG VAL LYS ASN LYS PRO LEU GLY PRO ALA GLY          
SEQRES  30 C  463  SER GLU ASN GLU ILE PRO THR HIS VAL LEU PRO PRO CYS          
SEQRES  31 C  463  ALA ASN LEU GLN ALA GLN LYS LEU LYS SER ASN VAL SER          
SEQRES  32 C  463  GLY SER THR HIS LEU CYS LEU SER ASP SER ASP PHE GLY          
SEQRES  33 C  463  LYS ASP GLY LEU ALA GLY ALA SER SER HIS ILE THR THR          
SEQRES  34 C  463  LYS SER MET ALA ALA PRO PRO SER CYS SER LEU SER SER          
SEQRES  35 C  463  LEU PRO VAL LEU MET LEU THR ALA LEU ALA ALA LEU LEU          
SEQRES  36 C  463  SER VAL SER LEU ALA GLU THR SER                              
SEQRES   1 D  134  SER PRO ASP LYS GLN MET ALA VAL LEU PRO ARG ARG GLU          
SEQRES   2 D  134  ARG ASN ARG GLN ALA ALA ALA ALA ASN PRO GLU ASN SER          
SEQRES   3 D  134  ARG GLY LYS GLY ARG ARG GLY GLN ARG GLY LYS ASN ARG          
SEQRES   4 D  134  GLY CYS VAL LEU THR ALA ILE HIS LEU ASN VAL THR ASP          
SEQRES   5 D  134  LEU GLY LEU GLY TYR GLU THR LYS GLU GLU LEU ILE PHE          
SEQRES   6 D  134  ARG TYR CYS SER GLY SER CYS ASP ALA ALA GLU THR THR          
SEQRES   7 D  134  TYR ASP LYS ILE LEU LYS ASN LEU SER ARG ASN ARG ARG          
SEQRES   8 D  134  LEU VAL SER ASP LYS VAL GLY GLN ALA CYS CYS ARG PRO          
SEQRES   9 D  134  ILE ALA PHE ASP ASP ASP LEU SER PHE LEU ASP ASP ASN          
SEQRES  10 D  134  LEU VAL TYR HIS ILE LEU ARG LYS HIS SER ALA LYS ARG          
SEQRES  11 D  134  CYS GLY CYS ILE                                              
SEQRES   1 E  463  MET PHE LEU ALA THR LEU TYR PHE ALA LEU PRO LEU LEU          
SEQRES   2 E  463  ASP LEU LEU MET SER ALA GLU VAL SER GLY GLY ASP ARG          
SEQRES   3 E  463  LEU ASP CYS VAL LYS ALA SER ASP GLN CYS LEU LYS GLU          
SEQRES   4 E  463  GLN SER CYS SER THR LYS TYR ARG THR LEU ARG GLN CYS          
SEQRES   5 E  463  VAL ALA GLY LYS GLU THR ASN PHE SER LEU THR SER GLY          
SEQRES   6 E  463  LEU GLU ALA LYS ASP GLU CYS ARG SER ALA MET GLU ALA          
SEQRES   7 E  463  LEU LYS GLN LYS SER LEU TYR ASN CYS ARG CYS LYS ARG          
SEQRES   8 E  463  GLY MET LYS LYS GLU LYS ASN CYS LEU ARG ILE TYR TRP          
SEQRES   9 E  463  SER MET TYR GLN SER LEU GLN GLY ASN ASP LEU LEU GLU          
SEQRES  10 E  463  ASP SER PRO TYR GLU PRO VAL ASN SER ARG LEU SER ASP          
SEQRES  11 E  463  ILE PHE ARG ALA VAL PRO PHE ILE SER VAL GLU HIS ILE          
SEQRES  12 E  463  SER LYS GLY ASN ASN CYS LEU ASP ALA ALA LYS ALA CYS          
SEQRES  13 E  463  ASN LEU ASP ASP THR CYS LYS LYS TYR ARG SER ALA TYR          
SEQRES  14 E  463  ILE THR PRO CYS THR THR SER MET SER ASN GLU VAL CYS          
SEQRES  15 E  463  ASN ARG ARG LYS CYS HIS LYS ALA LEU ARG GLN PHE PHE          
SEQRES  16 E  463  ASP LYS VAL PRO ALA LYS HIS SER TYR GLY MET LEU PHE          
SEQRES  17 E  463  CYS SER CYS ARG ASP ILE ALA CYS THR GLU ARG ARG ARG          
SEQRES  18 E  463  GLN THR ILE VAL PRO VAL CYS SER TYR GLU GLU ARG GLU          
SEQRES  19 E  463  ARG PRO ASN CYS LEU SER LEU GLN ASP SER CYS LYS THR          
SEQRES  20 E  463  ASN TYR ILE CYS ARG SER ARG LEU ALA ASP PHE PHE THR          
SEQRES  21 E  463  ASN CYS GLN PRO GLU SER ARG SER VAL SER ASN CYS LEU          
SEQRES  22 E  463  LYS GLU ASN TYR ALA ASP CYS LEU LEU ALA TYR SER GLY          
SEQRES  23 E  463  LEU ILE GLY THR VAL MET THR PRO ASN TYR VAL ASP SER          
SEQRES  24 E  463  SER SER LEU SER VAL ALA PRO TRP CYS ASP CYS SER ASN          
SEQRES  25 E  463  SER GLY ASN ASP LEU GLU ASP CYS LEU LYS PHE LEU ASN          
SEQRES  26 E  463  PHE PHE LYS ASP ASN THR CYS LEU LYS ASN ALA ILE GLN          
SEQRES  27 E  463  ALA PHE GLY ASN GLY SER ASP VAL THR MET TRP GLN PRO          
SEQRES  28 E  463  ALA PRO PRO VAL GLN THR THR THR ALA THR THR THR THR          
SEQRES  29 E  463  ALA PHE ARG VAL LYS ASN LYS PRO LEU GLY PRO ALA GLY          
SEQRES  30 E  463  SER GLU ASN GLU ILE PRO THR HIS VAL LEU PRO PRO CYS          
SEQRES  31 E  463  ALA ASN LEU GLN ALA GLN LYS LEU LYS SER ASN VAL SER          
SEQRES  32 E  463  GLY SER THR HIS LEU CYS LEU SER ASP SER ASP PHE GLY          
SEQRES  33 E  463  LYS ASP GLY LEU ALA GLY ALA SER SER HIS ILE THR THR          
SEQRES  34 E  463  LYS SER MET ALA ALA PRO PRO SER CYS SER LEU SER SER          
SEQRES  35 E  463  LEU PRO VAL LEU MET LEU THR ALA LEU ALA ALA LEU LEU          
SEQRES  36 E  463  SER VAL SER LEU ALA GLU THR SER                              
SEQRES   1 F  134  SER PRO ASP LYS GLN MET ALA VAL LEU PRO ARG ARG GLU          
SEQRES   2 F  134  ARG ASN ARG GLN ALA ALA ALA ALA ASN PRO GLU ASN SER          
SEQRES   3 F  134  ARG GLY LYS GLY ARG ARG GLY GLN ARG GLY LYS ASN ARG          
SEQRES   4 F  134  GLY CYS VAL LEU THR ALA ILE HIS LEU ASN VAL THR ASP          
SEQRES   5 F  134  LEU GLY LEU GLY TYR GLU THR LYS GLU GLU LEU ILE PHE          
SEQRES   6 F  134  ARG TYR CYS SER GLY SER CYS ASP ALA ALA GLU THR THR          
SEQRES   7 F  134  TYR ASP LYS ILE LEU LYS ASN LEU SER ARG ASN ARG ARG          
SEQRES   8 F  134  LEU VAL SER ASP LYS VAL GLY GLN ALA CYS CYS ARG PRO          
SEQRES   9 F  134  ILE ALA PHE ASP ASP ASP LEU SER PHE LEU ASP ASP ASN          
SEQRES  10 F  134  LEU VAL TYR HIS ILE LEU ARG LYS HIS SER ALA LYS ARG          
SEQRES  11 F  134  CYS GLY CYS ILE                                              
MODRES 4UX8 ASN F   49  ASN  GLYCOSYLATION SITE                                 
MODRES 4UX8 ASN D   49  ASN  GLYCOSYLATION SITE                                 
HET    NAG  G   1      14                                                       
HET    NAG  G   2      14                                                       
HET    NAG  H   1      14                                                       
HET    NAG  H   2      14                                                       
HET     CA  A1603       1                                                       
HET     CA  A1604       1                                                       
HET     CA  A1605       1                                                       
HET     CA  B1603       1                                                       
HET     CA  B1604       1                                                       
HET     CA  B1605       1                                                       
HETNAM     NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE                         
HETNAM      CA CALCIUM ION                                                      
FORMUL   7  NAG    4(C8 H15 N O6)                                               
FORMUL   9   CA    6(CA 2+)                                                     
HELIX    1   1 THR A   75  ARG A   77  5                                   3    
HELIX    2   2 ASP A  102  ARG A  112  1                                  11    
HELIX    3   3 ALA A  156  LEU A  160  5                                   5    
HELIX    4   4 LYS A  161  PHE A  167  1                                   7    
HELIX    5   5 LEU A  190  CYS A  197  1                                   8    
HELIX    6   6 ALA A  306  VAL A  311  1                                   6    
HELIX    7   7 VAL A  425  SER A  434  1                                  10    
HELIX    8   8 THR B   75  ARG B   77  5                                   3    
HELIX    9   9 ASP B  102  ARG B  112  1                                  11    
HELIX   10  10 ALA B  156  LEU B  160  5                                   5    
HELIX   11  11 LYS B  161  PHE B  167  1                                   7    
HELIX   12  12 LEU B  190  CYS B  197  1                                   8    
HELIX   13  13 ALA B  306  VAL B  311  1                                   6    
HELIX   14  14 VAL B  425  SER B  434  1                                  10    
HELIX   15  15 ASP C    9  GLU C   20  1                                  12    
HELIX   16  16 GLU C   20  VAL C   34  1                                  15    
HELIX   17  17 ALA C   49  LEU C   60  1                                  12    
HELIX   18  18 LYS C   76  GLN C   89  1                                  14    
HELIX   19  19 ASN C  152  LEU C  163  1                                  12    
HELIX   20  20 ASP C  164  THR C  179  1                                  16    
HELIX   21  21 ASN C  188  VAL C  203  1                                  16    
HELIX   22  22 PRO C  204  PHE C  213  1                                  10    
HELIX   23  23 ASP C  218  THR C  228  1                                  11    
HELIX   24  24 VAL C  230  TYR C  235  1                                   6    
HELIX   25  25 ASN C  242  ASN C  253  1                                  12    
HELIX   26  26 ASN C  253  CYS C  267  1                                  15    
HELIX   27  27 LEU C  278  GLU C  280  5                                   3    
HELIX   28  28 ASN C  281  GLY C  291  1                                  11    
HELIX   29  29 SER C  318  ASN C  320  5                                   3    
HELIX   30  30 ASP C  321  ASP C  334  1                                  14    
HELIX   31  31 ASN C  335  ASN C  347  1                                  13    
HELIX   32  32 THR D   51  GLY D   54  5                                   4    
HELIX   33  33 THR D   77  ASN D   89  1                                  13    
HELIX   34  34 ASP E    9  GLU E   20  1                                  12    
HELIX   35  35 GLU E   20  VAL E   34  1                                  15    
HELIX   36  36 ALA E   49  LEU E   60  1                                  12    
HELIX   37  37 LYS E   76  GLN E   89  1                                  14    
HELIX   38  38 ASN E  152  LEU E  163  1                                  12    
HELIX   39  39 ASP E  164  THR E  179  1                                  16    
HELIX   40  40 ASN E  188  VAL E  203  1                                  16    
HELIX   41  41 PRO E  204  PHE E  213  1                                  10    
HELIX   42  42 ASP E  218  THR E  228  1                                  11    
HELIX   43  43 VAL E  230  TYR E  235  1                                   6    
HELIX   44  44 ASN E  242  ASN E  253  1                                  12    
HELIX   45  45 ASN E  253  CYS E  267  1                                  15    
HELIX   46  46 LEU E  278  GLU E  280  5                                   3    
HELIX   47  47 ASN E  281  GLY E  291  1                                  11    
HELIX   48  48 SER E  318  ASN E  320  5                                   3    
HELIX   49  49 ASP E  321  ASP E  334  1                                  14    
HELIX   50  50 ASN E  335  ASN E  347  1                                  13    
HELIX   51  51 THR F   51  GLY F   54  5                                   4    
HELIX   52  52 THR F   77  ASN F   89  1                                  13    
SHEET    1  AA 2 TYR A  30  PHE A  31  0                                        
SHEET    2  AA 2 ALA A  55  LEU A  56 -1  O  LEU A  56   N  TYR A  30           
SHEET    1  AB 4 ALA A  35  TYR A  41  0                                        
SHEET    2  AB 4 CYS A 142  PHE A 150  1  O  ARG A 144   N  TYR A  36           
SHEET    3  AB 4 THR A 120  PHE A 126 -1  O  VAL A 121   N  PHE A 147           
SHEET    4  AB 4 ARG A  67  LEU A  68 -1  O  ARG A  67   N  PHE A 126           
SHEET    1  AC 3 PRO A  49  TYR A  52  0                                        
SHEET    2  AC 3 LEU A  94  LEU A  97 -1  O  LEU A  95   N  LEU A  50           
SHEET    3  AC 3 ILE A  86  ILE A  88 -1  O  ARG A  87   N  TYR A  96           
SHEET    1  AD 2 HIS A  71  TYR A  73  0                                        
SHEET    2  AD 2 ARG A  79  GLU A  82 -1  N  LEU A  80   O  LEU A  72           
SHEET    1  AE 4 PHE A 174  ARG A 177  0                                        
SHEET    2  AE 4 GLU A 252  TYR A 263  1  O  PRO A 259   N  PHE A 174           
SHEET    3  AE 4 LYS A 236  VAL A 245 -1  O  TYR A 237   N  VAL A 260           
SHEET    4  AE 4 VAL A 202  LEU A 207 -1  O  ALA A 203   N  THR A 244           
SHEET    1  AF 3 THR A 184  GLN A 187  0                                        
SHEET    2  AF 3 GLU A 222  THR A 225 -1  O  VAL A 223   N  PHE A 185           
SHEET    3  AF 3 PHE A 214  ARG A 215 -1  O  ARG A 215   N  SER A 224           
SHEET    1  AG 2 PRO A 270  THR A 271  0                                        
SHEET    2  AG 2 PHE A 299  ASP A 300 -1  O  PHE A 299   N  THR A 271           
SHEET    1  AH 4 VAL A 276  ASP A 277  0                                        
SHEET    2  AH 4 THR A 369  LEU A 372  1  O  GLN A 371   N  ASP A 277           
SHEET    3  AH 4 TYR A 354  VAL A 357 -1  O  TYR A 354   N  LEU A 372           
SHEET    4  AH 4 THR A 315  LEU A 318 -1  O  THR A 315   N  VAL A 357           
SHEET    1  AI 2 ALA A 281  VAL A 283  0                                        
SHEET    2  AI 2 LEU A 375  ASN A 377  1  O  LEU A 375   N  VAL A 282           
SHEET    1  AJ 3 THR A 291  THR A 295  0                                        
SHEET    2  AJ 3 SER A 339  ALA A 342 -1  O  VAL A 340   N  VAL A 293           
SHEET    3  AJ 3 PHE A 329  VAL A 331 -1  O  ARG A 330   N  GLN A 341           
SHEET    1  AK 4 TYR A 408  SER A 409  0                                        
SHEET    2  AK 4 ALA A 498  THR A 503  1  O  LEU A 501   N  TYR A 408           
SHEET    3  AK 4 GLU A 480  THR A 488 -1  O  LEU A 481   N  VAL A 502           
SHEET    4  AK 4 GLN A 439  HIS A 443 -1  O  GLN A 439   N  THR A 488           
SHEET    1  AL 3 ALA A 420  LYS A 424  0                                        
SHEET    2  AL 3 ILE A 464  VAL A 467 -1  O  LEU A 465   N  GLY A 423           
SHEET    3  AL 3 VAL A 455  THR A 456 -1  O  THR A 456   N  PHE A 466           
SHEET    1  BA 2 TYR B  30  PHE B  31  0                                        
SHEET    2  BA 2 ALA B  55  LEU B  56 -1  O  LEU B  56   N  TYR B  30           
SHEET    1  BB 4 ALA B  35  TYR B  41  0                                        
SHEET    2  BB 4 CYS B 142  PHE B 150  1  O  ARG B 144   N  TYR B  36           
SHEET    3  BB 4 THR B 120  PHE B 126 -1  O  VAL B 121   N  PHE B 147           
SHEET    4  BB 4 ARG B  67  LEU B  68 -1  O  ARG B  67   N  PHE B 126           
SHEET    1  BC 3 PRO B  49  TYR B  52  0                                        
SHEET    2  BC 3 LEU B  94  LEU B  97 -1  O  LEU B  95   N  LEU B  50           
SHEET    3  BC 3 ILE B  86  ILE B  88 -1  O  ARG B  87   N  TYR B  96           
SHEET    1  BD 2 HIS B  71  TYR B  73  0                                        
SHEET    2  BD 2 ARG B  79  GLU B  82 -1  N  LEU B  80   O  LEU B  72           
SHEET    1  BE 4 PHE B 174  ARG B 177  0                                        
SHEET    2  BE 4 GLU B 252  TYR B 263  1  O  PRO B 259   N  PHE B 174           
SHEET    3  BE 4 LYS B 236  VAL B 245 -1  O  TYR B 237   N  VAL B 260           
SHEET    4  BE 4 VAL B 202  LEU B 207 -1  O  ALA B 203   N  THR B 244           
SHEET    1  BF 3 THR B 184  GLN B 187  0                                        
SHEET    2  BF 3 GLU B 222  THR B 225 -1  O  VAL B 223   N  PHE B 185           
SHEET    3  BF 3 PHE B 214  ARG B 215 -1  O  ARG B 215   N  SER B 224           
SHEET    1  BG 2 PRO B 270  THR B 271  0                                        
SHEET    2  BG 2 PHE B 299  ASP B 300 -1  O  PHE B 299   N  THR B 271           
SHEET    1  BH 4 VAL B 276  ASP B 277  0                                        
SHEET    2  BH 4 THR B 369  LEU B 372  1  O  GLN B 371   N  ASP B 277           
SHEET    3  BH 4 TYR B 354  VAL B 357 -1  O  TYR B 354   N  LEU B 372           
SHEET    4  BH 4 THR B 315  LEU B 318 -1  O  THR B 315   N  VAL B 357           
SHEET    1  BI 2 ALA B 281  VAL B 282  0                                        
SHEET    2  BI 2 LEU B 375  VAL B 376  1  O  LEU B 375   N  VAL B 282           
SHEET    1  BJ 3 THR B 291  THR B 295  0                                        
SHEET    2  BJ 3 SER B 339  ALA B 342 -1  O  VAL B 340   N  VAL B 293           
SHEET    3  BJ 3 PHE B 329  VAL B 331 -1  O  ARG B 330   N  GLN B 341           
SHEET    1  BK 4 TYR B 408  SER B 409  0                                        
SHEET    2  BK 4 ALA B 498  THR B 503  1  O  LEU B 501   N  TYR B 408           
SHEET    3  BK 4 GLU B 480  THR B 488 -1  O  LEU B 481   N  VAL B 502           
SHEET    4  BK 4 GLN B 439  HIS B 443 -1  O  GLN B 439   N  THR B 488           
SHEET    1  BL 3 ALA B 420  LYS B 424  0                                        
SHEET    2  BL 3 ILE B 464  VAL B 467 -1  O  LEU B 465   N  GLY B 423           
SHEET    3  BL 3 VAL B 455  THR B 456 -1  O  THR B 456   N  PHE B 466           
SHEET    1  CA 2 ASN C 300  TYR C 301  0                                        
SHEET    2  CA 2 VAL C 309  ALA C 310 -1  O  ALA C 310   N  ASN C 300           
SHEET    1  DA 2 LEU D  43  ASN D  49  0                                        
SHEET    2  DA 2 GLU D  62  CYS D  68 -1  O  LEU D  63   N  LEU D  48           
SHEET    1  DB 2 CYS D 101  PHE D 107  0                                        
SHEET    2  DB 2 ALA D 128  ILE D 134 -1  N  LYS D 129   O  ALA D 106           
SHEET    1  DC 2 LEU D 111  LEU D 114  0                                        
SHEET    2  DC 2 TYR D 120  LEU D 123 -1  O  HIS D 121   N  PHE D 113           
SHEET    1  EA 2 ASN E 300  TYR E 301  0                                        
SHEET    2  EA 2 VAL E 309  ALA E 310 -1  O  ALA E 310   N  ASN E 300           
SHEET    1  FA 2 LEU F  43  ASN F  49  0                                        
SHEET    2  FA 2 GLU F  62  CYS F  68 -1  O  LEU F  63   N  LEU F  48           
SHEET    1  FB 2 CYS F 101  PHE F 107  0                                        
SHEET    2  FB 2 ALA F 128  ILE F 134 -1  N  LYS F 129   O  ALA F 106           
SHEET    1  FC 2 LEU F 111  LEU F 114  0                                        
SHEET    2  FC 2 TYR F 120  LEU F 123 -1  O  HIS F 121   N  PHE F 113           
SSBOND   1 CYS A  137    CYS A  142                          1555   1555  2.04  
SSBOND   2 CYS A  157    CYS A  197                          1555   1555  2.14  
SSBOND   3 CYS A  166    CYS A  243                          1555   1555  2.04  
SSBOND   4 CYS B  137    CYS B  142                          1555   1555  2.04  
SSBOND   5 CYS B  157    CYS B  197                          1555   1555  2.14  
SSBOND   6 CYS B  166    CYS B  243                          1555   1555  2.04  
SSBOND   7 CYS C   17    CYS C   23                          1555   1555  2.03  
SSBOND   8 CYS C  154    CYS C  214                          1555   1555  2.03  
SSBOND   9 CYS C  161    CYS C  167                          1555   1555  2.03  
SSBOND  10 CYS C  178    CYS C  192                          1555   1555  2.03  
SSBOND  11 CYS C  187    CYS C  233                          1555   1555  2.04  
SSBOND  12 CYS C  216    CYS C  221                          1555   1555  2.05  
SSBOND  13 CYS C  243    CYS C  313                          1555   1555  2.04  
SSBOND  14 CYS C  250    CYS C  256                          1555   1555  2.02  
SSBOND  15 CYS C  267    CYS C  285                          1555   1555  2.05  
SSBOND  16 CYS C  277    CYS C  337                          1555   1555  2.03  
SSBOND  17 CYS C  315    CYS C  325                          1555   1555  2.05  
SSBOND  18 CYS D   68    CYS D  131                          1555   1555  2.03  
SSBOND  19 CYS D   72    CYS D  133                          1555   1555  2.03  
SSBOND  20 CYS D  101    CYS F  101                          1555   1555  2.05  
SSBOND  21 CYS E   17    CYS E   23                          1555   1555  2.03  
SSBOND  22 CYS E  154    CYS E  214                          1555   1555  2.03  
SSBOND  23 CYS E  161    CYS E  167                          1555   1555  2.03  
SSBOND  24 CYS E  178    CYS E  192                          1555   1555  2.03  
SSBOND  25 CYS E  187    CYS E  233                          1555   1555  2.04  
SSBOND  26 CYS E  216    CYS E  221                          1555   1555  2.05  
SSBOND  27 CYS E  243    CYS E  313                          1555   1555  2.04  
SSBOND  28 CYS E  250    CYS E  256                          1555   1555  2.02  
SSBOND  29 CYS E  267    CYS E  285                          1555   1555  2.05  
SSBOND  30 CYS E  277    CYS E  337                          1555   1555  2.03  
SSBOND  31 CYS E  315    CYS E  325                          1555   1555  2.05  
SSBOND  32 CYS F   68    CYS F  131                          1555   1555  2.03  
SSBOND  33 CYS F   72    CYS F  133                          1555   1555  2.03  
LINK         ND2 ASN D  49                 C1  NAG G   1     1555   1555  1.45  
LINK         ND2 ASN F  49                 C1  NAG H   1     1555   1555  1.45  
LINK         O4  NAG G   1                 C1  NAG G   2     1555   1555  1.46  
LINK         O4  NAG H   1                 C1  NAG H   2     1555   1555  1.45  
LINK         OE2 GLU A 178                CA    CA A1603     1555   1555  2.56  
LINK         OE1 GLU A 178                CA    CA A1604     1555   1555  3.17  
LINK         OD1 ASP A 230                CA    CA A1604     1555   1555  2.02  
LINK         OD1 ASP A 264                CA    CA A1603     1555   1555  2.90  
LINK         OD2 ASP A 264                CA    CA A1603     1555   1555  2.68  
LINK         O   GLU A 265                CA    CA A1603     1555   1555  2.34  
LINK         OD1 ASP A 266                CA    CA A1605     1555   1555  2.62  
LINK         OD1 ASP A 267                CA    CA A1603     1555   1555  2.48  
LINK         OD2 ASP A 267                CA    CA A1604     1555   1555  2.37  
LINK         O   SER A 268                CA    CA A1605     1555   1555  2.26  
LINK         OD2 ASP A 300                CA    CA A1605     1555   1555  3.01  
LINK         OD2 ASP A 302                CA    CA A1605     1555   1555  1.85  
LINK         O   GLY A 308                CA    CA A1605     1555   1555  2.82  
LINK         NH1 ARG A 360                CA    CA A1605     1555   1555  2.59  
LINK         OE2 GLU B 178                CA    CA B1603     1555   1555  2.56  
LINK         OE1 GLU B 178                CA    CA B1604     1555   1555  3.17  
LINK         OD1 ASP B 230                CA    CA B1604     1555   1555  2.02  
LINK         OD2 ASP B 264                CA    CA B1603     1555   1555  2.68  
LINK         OD1 ASP B 264                CA    CA B1603     1555   1555  2.90  
LINK         O   GLU B 265                CA    CA B1603     1555   1555  2.34  
LINK         OD1 ASP B 266                CA    CA B1605     1555   1555  2.62  
LINK         OD1 ASP B 267                CA    CA B1603     1555   1555  2.48  
LINK         OD2 ASP B 267                CA    CA B1604     1555   1555  2.37  
LINK         O   SER B 268                CA    CA B1605     1555   1555  2.26  
LINK         OD2 ASP B 300                CA    CA B1605     1555   1555  3.01  
LINK         OD2 ASP B 302                CA    CA B1605     1555   1555  1.85  
LINK         O   GLY B 308                CA    CA B1605     1555   1555  2.82  
LINK         NH1 ARG B 360                CA    CA B1605     1555   1555  2.59  
CISPEP   1 TRP A  139    PRO A  140          0         8.66                     
CISPEP   2 PRO A  320    GLY A  321          0        -3.68                     
CISPEP   3 THR A  323    TRP A  324          0        -4.18                     
CISPEP   4 TRP B  139    PRO B  140          0         8.61                     
CISPEP   5 PRO B  320    GLY B  321          0        -3.66                     
CISPEP   6 THR B  323    TRP B  324          0        -4.08                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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