GenomeNet

Database: PDB
Entry: 4Y97
LinkDB: 4Y97
Original site: 4Y97 
HEADER    TRANSFERASE                             17-FEB-15   4Y97              
TITLE     CRYSTAL STRUCTURE OF HUMAN POL ALPHA B-SUBUNIT IN COMPLEX WITH C-     
TITLE    2 TERMINAL DOMAIN OF CATALYTIC SUBUNIT                                 
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: DNA POLYMERASE ALPHA SUBUNIT B;                            
COMPND   3 CHAIN: A, C, E, G;                                                   
COMPND   4 SYNONYM: DNA POLYMERASE ALPHA 70 KDA SUBUNIT;                        
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT;                    
COMPND   8 CHAIN: B, D, F, H;                                                   
COMPND   9 FRAGMENT: UNP RESIDUES 1265-1444;                                    
COMPND  10 SYNONYM: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT P180;                
COMPND  11 EC: 2.7.7.7;                                                         
COMPND  12 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: POLA2;                                                         
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: ROSETTA-2;                                 
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 GENE: POLA1, POLA;                                                   
SOURCE  14 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  15 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  16 EXPRESSION_SYSTEM_STRAIN: ROSETTA-2                                  
KEYWDS    HUMAN DNA POLYMERASE ALPHA, TRANSFERASE                               
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    Y.SUWA,J.GU,A.G.BARANOVSKIY,N.D.BABAYEVA,T.H.TAHIROV                  
REVDAT   5   25-DEC-19 4Y97    1       REMARK                                   
REVDAT   4   13-SEP-17 4Y97    1       SOURCE JRNL   REMARK                     
REVDAT   3   17-JUN-15 4Y97    1       JRNL                                     
REVDAT   2   22-APR-15 4Y97    1       JRNL                                     
REVDAT   1   15-APR-15 4Y97    0                                                
JRNL        AUTH   Y.SUWA,J.GU,A.G.BARANOVSKIY,N.D.BABAYEVA,Y.I.PAVLOV,         
JRNL        AUTH 2 T.H.TAHIROV                                                  
JRNL        TITL   CRYSTAL STRUCTURE OF THE HUMAN POL ALPHA B SUBUNIT IN        
JRNL        TITL 2 COMPLEX WITH THE C-TERMINAL DOMAIN OF THE CATALYTIC SUBUNIT. 
JRNL        REF    J.BIOL.CHEM.                  V. 290 14328 2015              
JRNL        REFN                   ESSN 1083-351X                               
JRNL        PMID   25847248                                                     
JRNL        DOI    10.1074/JBC.M115.649954                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.51 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS 1.1                                              
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-              
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES,PANNU,              
REMARK   3               : READ,RICE,SIMONSON,WARREN                            
REMARK   3                                                                      
REMARK   3  REFINEMENT TARGET : NULL                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.51                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.68                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : 3140059.930                    
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : 0.0000                         
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 94.2                           
REMARK   3   NUMBER OF REFLECTIONS             : 116874                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.218                           
REMARK   3   FREE R VALUE                     : 0.257                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 5894                            
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.030                           
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 6                            
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.50                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.66                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 80.20                        
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 15819                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.4160                       
REMARK   3   BIN FREE R VALUE                    : 0.4340                       
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 5.20                         
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 868                          
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.015                        
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 19514                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 8                                       
REMARK   3   SOLVENT ATOMS            : 202                                     
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 41.60                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 50.70                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 0.41000                                              
REMARK   3    B22 (A**2) : -1.34000                                             
REMARK   3    B33 (A**2) : 0.93000                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 2.32000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.35                            
REMARK   3   ESD FROM SIGMAA              (A) : 0.66                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.42                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.79                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : 0.008                           
REMARK   3   BOND ANGLES            (DEGREES) : 1.700                           
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 25.00                           
REMARK   3   IMPROPER ANGLES        (DEGREES) : 1.000                           
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : RESTRAINED                                
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELING.                                              
REMARK   3   METHOD USED : FLAT MODEL                                           
REMARK   3   KSOL        : 0.32                                                 
REMARK   3   BSOL        : 31.12                                                
REMARK   3                                                                      
REMARK   3  NCS MODEL : CONSTR                                                  
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : ../TOPPAR/PROTEIN_REP.PARAM                    
REMARK   3  PARAMETER FILE  2  : CNS_TOPPAR/DNA-RNA_REP.PARAM                   
REMARK   3  PARAMETER FILE  3  : ../TOPPAR/WATER_REP.PARAM                      
REMARK   3  PARAMETER FILE  4  : CNS_TOPPAR/CARBOHYDRATE.PARAM                  
REMARK   3  PARAMETER FILE  5  : ../TOPPAR/ION.PARAM                            
REMARK   3  PARAMETER FILE  6  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : ../TOPPAR/PROTEIN.TOP                          
REMARK   3  TOPOLOGY FILE  2   : CNS_TOPPAR/DNA-RNA.TOP                         
REMARK   3  TOPOLOGY FILE  3   : ../TOPPAR/WATER.TOP                            
REMARK   3  TOPOLOGY FILE  4   : CNS_TOPPAR/CARBOHYDRATE.TOP                    
REMARK   3  TOPOLOGY FILE  5   : CNS_TOPPAR/ION.TOP                             
REMARK   3  TOPOLOGY FILE  6   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 4Y97 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-FEB-15.                  
REMARK 100 THE DEPOSITION ID IS D_1000207065.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 17-NOV-13                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 5.6                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 24-ID-E                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9792                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315                   
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 116900                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.500                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -1.000                             
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 95.0                               
REMARK 200  DATA REDUNDANCY                : 2.800                              
REMARK 200  R MERGE                    (I) : 0.08400                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 13.3500                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.50                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.54                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 88.5                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.10                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.39600                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.050                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHENIX                                                
REMARK 200 STARTING MODEL: 3FLO                                                 
REMARK 200                                                                      
REMARK 200 REMARK: ELONGATED PLATE                                              
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 53.42                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.64                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: THE DIFFRACTION QUALITY CRYSTALS ARE     
REMARK 280  GROWING IN 2-3 WEEKS IN 100 MM AMMONIUM ACETATE, 50 MM NA           
REMARK 280  CITRATE PH 5.6, 10 - 10.4% W/V PEG 4000, 2 MM TCEP AND 50 MM        
REMARK 280  GUANIDINE HCL., VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 295K     
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y+1/2,-Z                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       68.56750            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3, 4                                              
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3460 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 27500 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -18.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 4060 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 27150 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -21.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3430 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 27810 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -22.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 4                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3970 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 27240 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -21.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, H                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     ALA A     5                                                      
REMARK 465     GLN A     6                                                      
REMARK 465     GLN A     7                                                      
REMARK 465     LEU A     8                                                      
REMARK 465     ALA A     9                                                      
REMARK 465     GLU A    10                                                      
REMARK 465     GLU A    11                                                      
REMARK 465     LEU A    12                                                      
REMARK 465     GLN A    13                                                      
REMARK 465     ILE A    14                                                      
REMARK 465     PHE A    15                                                      
REMARK 465     GLY A    16                                                      
REMARK 465     LEU A    17                                                      
REMARK 465     ASP A    18                                                      
REMARK 465     CYS A    19                                                      
REMARK 465     GLU A    20                                                      
REMARK 465     GLU A    21                                                      
REMARK 465     ALA A    22                                                      
REMARK 465     LEU A    23                                                      
REMARK 465     ILE A    24                                                      
REMARK 465     GLU A    25                                                      
REMARK 465     LYS A    26                                                      
REMARK 465     LEU A    27                                                      
REMARK 465     VAL A    28                                                      
REMARK 465     GLU A    29                                                      
REMARK 465     LEU A    30                                                      
REMARK 465     CYS A    31                                                      
REMARK 465     VAL A    32                                                      
REMARK 465     GLN A    33                                                      
REMARK 465     TYR A    34                                                      
REMARK 465     GLY A    35                                                      
REMARK 465     GLN A    36                                                      
REMARK 465     ASN A    37                                                      
REMARK 465     GLU A    38                                                      
REMARK 465     GLU A    39                                                      
REMARK 465     GLY A    40                                                      
REMARK 465     MET A    41                                                      
REMARK 465     VAL A    42                                                      
REMARK 465     GLY A    43                                                      
REMARK 465     GLU A    44                                                      
REMARK 465     LEU A    45                                                      
REMARK 465     ILE A    46                                                      
REMARK 465     ALA A    47                                                      
REMARK 465     PHE A    48                                                      
REMARK 465     CYS A    49                                                      
REMARK 465     THR A    50                                                      
REMARK 465     SER A    51                                                      
REMARK 465     THR A    52                                                      
REMARK 465     HIS A    53                                                      
REMARK 465     LYS A    54                                                      
REMARK 465     VAL A    55                                                      
REMARK 465     GLY A    56                                                      
REMARK 465     LEU A    57                                                      
REMARK 465     THR A    58                                                      
REMARK 465     SER A    59                                                      
REMARK 465     GLU A    60                                                      
REMARK 465     ILE A    61                                                      
REMARK 465     LEU A    62                                                      
REMARK 465     ASN A    63                                                      
REMARK 465     SER A    64                                                      
REMARK 465     PHE A    65                                                      
REMARK 465     GLU A    66                                                      
REMARK 465     HIS A    67                                                      
REMARK 465     GLU A    68                                                      
REMARK 465     PHE A    69                                                      
REMARK 465     LEU A    70                                                      
REMARK 465     SER A    71                                                      
REMARK 465     LYS A    72                                                      
REMARK 465     ARG A    73                                                      
REMARK 465     LEU A    74                                                      
REMARK 465     SER A    75                                                      
REMARK 465     LYS A    76                                                      
REMARK 465     ALA A    77                                                      
REMARK 465     ARG A    78                                                      
REMARK 465     HIS A    79                                                      
REMARK 465     SER A    80                                                      
REMARK 465     THR A    81                                                      
REMARK 465     CYS A    82                                                      
REMARK 465     LYS A    83                                                      
REMARK 465     ASP A    84                                                      
REMARK 465     SER A    85                                                      
REMARK 465     GLY A    86                                                      
REMARK 465     HIS A    87                                                      
REMARK 465     ALA A    88                                                      
REMARK 465     GLY A    89                                                      
REMARK 465     ALA A    90                                                      
REMARK 465     ARG A    91                                                      
REMARK 465     ASP A    92                                                      
REMARK 465     ILE A    93                                                      
REMARK 465     VAL A    94                                                      
REMARK 465     SER A    95                                                      
REMARK 465     ILE A    96                                                      
REMARK 465     GLN A    97                                                      
REMARK 465     GLU A    98                                                      
REMARK 465     LEU A    99                                                      
REMARK 465     ILE A   100                                                      
REMARK 465     GLU A   101                                                      
REMARK 465     VAL A   102                                                      
REMARK 465     GLU A   103                                                      
REMARK 465     GLU A   104                                                      
REMARK 465     GLU A   105                                                      
REMARK 465     GLU A   106                                                      
REMARK 465     GLU A   107                                                      
REMARK 465     ILE A   108                                                      
REMARK 465     LEU A   109                                                      
REMARK 465     LEU A   110                                                      
REMARK 465     ASN A   111                                                      
REMARK 465     SER A   112                                                      
REMARK 465     TYR A   113                                                      
REMARK 465     THR A   114                                                      
REMARK 465     THR A   115                                                      
REMARK 465     PRO A   116                                                      
REMARK 465     SER A   117                                                      
REMARK 465     LYS A   118                                                      
REMARK 465     GLY A   119                                                      
REMARK 465     SER A   120                                                      
REMARK 465     GLN A   121                                                      
REMARK 465     LYS A   122                                                      
REMARK 465     ARG A   123                                                      
REMARK 465     ALA A   124                                                      
REMARK 465     ILE A   125                                                      
REMARK 465     SER A   126                                                      
REMARK 465     THR A   127                                                      
REMARK 465     PRO A   128                                                      
REMARK 465     GLU A   129                                                      
REMARK 465     THR A   130                                                      
REMARK 465     PRO A   131                                                      
REMARK 465     LEU A   132                                                      
REMARK 465     THR A   133                                                      
REMARK 465     LYS A   134                                                      
REMARK 465     ARG A   135                                                      
REMARK 465     SER A   136                                                      
REMARK 465     VAL A   137                                                      
REMARK 465     SER A   138                                                      
REMARK 465     THR A   139                                                      
REMARK 465     ARG A   140                                                      
REMARK 465     SER A   141                                                      
REMARK 465     PRO A   142                                                      
REMARK 465     HIS A   143                                                      
REMARK 465     GLN A   144                                                      
REMARK 465     LEU A   145                                                      
REMARK 465     LEU A   146                                                      
REMARK 465     SER A   147                                                      
REMARK 465     PRO A   148                                                      
REMARK 465     SER A   149                                                      
REMARK 465     SER A   150                                                      
REMARK 465     PHE A   151                                                      
REMARK 465     SER A   152                                                      
REMARK 465     PRO A   153                                                      
REMARK 465     SER A   154                                                      
REMARK 465     ALA A   155                                                      
REMARK 465     THR A   156                                                      
REMARK 465     ALA B  1265                                                      
REMARK 465     GLN B  1266                                                      
REMARK 465     LEU B  1267                                                      
REMARK 465     LEU B  1441                                                      
REMARK 465     SER B  1442                                                      
REMARK 465     ARG B  1443                                                      
REMARK 465     SER B  1444                                                      
REMARK 465     MET C     1                                                      
REMARK 465     SER C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     GLN C     6                                                      
REMARK 465     GLN C     7                                                      
REMARK 465     LEU C     8                                                      
REMARK 465     ALA C     9                                                      
REMARK 465     GLU C    10                                                      
REMARK 465     GLU C    11                                                      
REMARK 465     LEU C    12                                                      
REMARK 465     GLN C    13                                                      
REMARK 465     ILE C    14                                                      
REMARK 465     PHE C    15                                                      
REMARK 465     GLY C    16                                                      
REMARK 465     LEU C    17                                                      
REMARK 465     ASP C    18                                                      
REMARK 465     CYS C    19                                                      
REMARK 465     GLU C    20                                                      
REMARK 465     GLU C    21                                                      
REMARK 465     ALA C    22                                                      
REMARK 465     LEU C    23                                                      
REMARK 465     ILE C    24                                                      
REMARK 465     GLU C    25                                                      
REMARK 465     LYS C    26                                                      
REMARK 465     LEU C    27                                                      
REMARK 465     VAL C    28                                                      
REMARK 465     GLU C    29                                                      
REMARK 465     LEU C    30                                                      
REMARK 465     CYS C    31                                                      
REMARK 465     VAL C    32                                                      
REMARK 465     GLN C    33                                                      
REMARK 465     TYR C    34                                                      
REMARK 465     GLY C    35                                                      
REMARK 465     GLN C    36                                                      
REMARK 465     ASN C    37                                                      
REMARK 465     GLU C    38                                                      
REMARK 465     GLU C    39                                                      
REMARK 465     GLY C    40                                                      
REMARK 465     MET C    41                                                      
REMARK 465     VAL C    42                                                      
REMARK 465     GLY C    43                                                      
REMARK 465     GLU C    44                                                      
REMARK 465     LEU C    45                                                      
REMARK 465     ILE C    46                                                      
REMARK 465     ALA C    47                                                      
REMARK 465     PHE C    48                                                      
REMARK 465     CYS C    49                                                      
REMARK 465     THR C    50                                                      
REMARK 465     SER C    51                                                      
REMARK 465     THR C    52                                                      
REMARK 465     HIS C    53                                                      
REMARK 465     LYS C    54                                                      
REMARK 465     VAL C    55                                                      
REMARK 465     GLY C    56                                                      
REMARK 465     LEU C    57                                                      
REMARK 465     THR C    58                                                      
REMARK 465     SER C    59                                                      
REMARK 465     GLU C    60                                                      
REMARK 465     ILE C    61                                                      
REMARK 465     LEU C    62                                                      
REMARK 465     ASN C    63                                                      
REMARK 465     SER C    64                                                      
REMARK 465     PHE C    65                                                      
REMARK 465     GLU C    66                                                      
REMARK 465     HIS C    67                                                      
REMARK 465     GLU C    68                                                      
REMARK 465     PHE C    69                                                      
REMARK 465     LEU C    70                                                      
REMARK 465     SER C    71                                                      
REMARK 465     LYS C    72                                                      
REMARK 465     ARG C    73                                                      
REMARK 465     LEU C    74                                                      
REMARK 465     SER C    75                                                      
REMARK 465     LYS C    76                                                      
REMARK 465     ALA C    77                                                      
REMARK 465     ARG C    78                                                      
REMARK 465     HIS C    79                                                      
REMARK 465     SER C    80                                                      
REMARK 465     THR C    81                                                      
REMARK 465     CYS C    82                                                      
REMARK 465     LYS C    83                                                      
REMARK 465     ASP C    84                                                      
REMARK 465     SER C    85                                                      
REMARK 465     GLY C    86                                                      
REMARK 465     HIS C    87                                                      
REMARK 465     ALA C    88                                                      
REMARK 465     GLY C    89                                                      
REMARK 465     ALA C    90                                                      
REMARK 465     ARG C    91                                                      
REMARK 465     ASP C    92                                                      
REMARK 465     ILE C    93                                                      
REMARK 465     VAL C    94                                                      
REMARK 465     SER C    95                                                      
REMARK 465     ILE C    96                                                      
REMARK 465     GLN C    97                                                      
REMARK 465     GLU C    98                                                      
REMARK 465     LEU C    99                                                      
REMARK 465     ILE C   100                                                      
REMARK 465     GLU C   101                                                      
REMARK 465     VAL C   102                                                      
REMARK 465     GLU C   103                                                      
REMARK 465     GLU C   104                                                      
REMARK 465     GLU C   105                                                      
REMARK 465     GLU C   106                                                      
REMARK 465     GLU C   107                                                      
REMARK 465     ILE C   108                                                      
REMARK 465     LEU C   109                                                      
REMARK 465     LEU C   110                                                      
REMARK 465     ASN C   111                                                      
REMARK 465     SER C   112                                                      
REMARK 465     TYR C   113                                                      
REMARK 465     THR C   114                                                      
REMARK 465     THR C   115                                                      
REMARK 465     PRO C   116                                                      
REMARK 465     SER C   117                                                      
REMARK 465     LYS C   118                                                      
REMARK 465     GLY C   119                                                      
REMARK 465     SER C   120                                                      
REMARK 465     GLN C   121                                                      
REMARK 465     LYS C   122                                                      
REMARK 465     ARG C   123                                                      
REMARK 465     ALA C   124                                                      
REMARK 465     ILE C   125                                                      
REMARK 465     SER C   126                                                      
REMARK 465     THR C   127                                                      
REMARK 465     PRO C   128                                                      
REMARK 465     GLU C   129                                                      
REMARK 465     THR C   130                                                      
REMARK 465     PRO C   131                                                      
REMARK 465     LEU C   132                                                      
REMARK 465     THR C   133                                                      
REMARK 465     LYS C   134                                                      
REMARK 465     ARG C   135                                                      
REMARK 465     SER C   136                                                      
REMARK 465     VAL C   137                                                      
REMARK 465     SER C   138                                                      
REMARK 465     THR C   139                                                      
REMARK 465     ARG C   140                                                      
REMARK 465     SER C   141                                                      
REMARK 465     PRO C   142                                                      
REMARK 465     HIS C   143                                                      
REMARK 465     GLN C   144                                                      
REMARK 465     LEU C   145                                                      
REMARK 465     LEU C   146                                                      
REMARK 465     SER C   147                                                      
REMARK 465     PRO C   148                                                      
REMARK 465     SER C   149                                                      
REMARK 465     SER C   150                                                      
REMARK 465     THR C   203                                                      
REMARK 465     GLY C   204                                                      
REMARK 465     SER C   205                                                      
REMARK 465     TYR C   206                                                      
REMARK 465     SER C   489                                                      
REMARK 465     GLY C   490                                                      
REMARK 465     THR C   491                                                      
REMARK 465     ALA D  1265                                                      
REMARK 465     GLN D  1266                                                      
REMARK 465     MET E     1                                                      
REMARK 465     SER E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     SER E     4                                                      
REMARK 465     ALA E     5                                                      
REMARK 465     GLN E     6                                                      
REMARK 465     GLN E     7                                                      
REMARK 465     LEU E     8                                                      
REMARK 465     ALA E     9                                                      
REMARK 465     GLU E    10                                                      
REMARK 465     GLU E    11                                                      
REMARK 465     LEU E    12                                                      
REMARK 465     GLN E    13                                                      
REMARK 465     ILE E    14                                                      
REMARK 465     PHE E    15                                                      
REMARK 465     GLY E    16                                                      
REMARK 465     LEU E    17                                                      
REMARK 465     ASP E    18                                                      
REMARK 465     CYS E    19                                                      
REMARK 465     GLU E    20                                                      
REMARK 465     GLU E    21                                                      
REMARK 465     ALA E    22                                                      
REMARK 465     LEU E    23                                                      
REMARK 465     ILE E    24                                                      
REMARK 465     GLU E    25                                                      
REMARK 465     LYS E    26                                                      
REMARK 465     LEU E    27                                                      
REMARK 465     VAL E    28                                                      
REMARK 465     GLU E    29                                                      
REMARK 465     LEU E    30                                                      
REMARK 465     CYS E    31                                                      
REMARK 465     VAL E    32                                                      
REMARK 465     GLN E    33                                                      
REMARK 465     TYR E    34                                                      
REMARK 465     GLY E    35                                                      
REMARK 465     GLN E    36                                                      
REMARK 465     ASN E    37                                                      
REMARK 465     GLU E    38                                                      
REMARK 465     GLU E    39                                                      
REMARK 465     GLY E    40                                                      
REMARK 465     MET E    41                                                      
REMARK 465     VAL E    42                                                      
REMARK 465     GLY E    43                                                      
REMARK 465     GLU E    44                                                      
REMARK 465     LEU E    45                                                      
REMARK 465     ILE E    46                                                      
REMARK 465     ALA E    47                                                      
REMARK 465     PHE E    48                                                      
REMARK 465     CYS E    49                                                      
REMARK 465     THR E    50                                                      
REMARK 465     SER E    51                                                      
REMARK 465     THR E    52                                                      
REMARK 465     HIS E    53                                                      
REMARK 465     LYS E    54                                                      
REMARK 465     VAL E    55                                                      
REMARK 465     GLY E    56                                                      
REMARK 465     LEU E    57                                                      
REMARK 465     THR E    58                                                      
REMARK 465     SER E    59                                                      
REMARK 465     GLU E    60                                                      
REMARK 465     ILE E    61                                                      
REMARK 465     LEU E    62                                                      
REMARK 465     ASN E    63                                                      
REMARK 465     SER E    64                                                      
REMARK 465     PHE E    65                                                      
REMARK 465     GLU E    66                                                      
REMARK 465     HIS E    67                                                      
REMARK 465     GLU E    68                                                      
REMARK 465     PHE E    69                                                      
REMARK 465     LEU E    70                                                      
REMARK 465     SER E    71                                                      
REMARK 465     LYS E    72                                                      
REMARK 465     ARG E    73                                                      
REMARK 465     LEU E    74                                                      
REMARK 465     SER E    75                                                      
REMARK 465     LYS E    76                                                      
REMARK 465     ALA E    77                                                      
REMARK 465     ARG E    78                                                      
REMARK 465     HIS E    79                                                      
REMARK 465     SER E    80                                                      
REMARK 465     THR E    81                                                      
REMARK 465     CYS E    82                                                      
REMARK 465     LYS E    83                                                      
REMARK 465     ASP E    84                                                      
REMARK 465     SER E    85                                                      
REMARK 465     GLY E    86                                                      
REMARK 465     HIS E    87                                                      
REMARK 465     ALA E    88                                                      
REMARK 465     GLY E    89                                                      
REMARK 465     ALA E    90                                                      
REMARK 465     ARG E    91                                                      
REMARK 465     ASP E    92                                                      
REMARK 465     ILE E    93                                                      
REMARK 465     VAL E    94                                                      
REMARK 465     SER E    95                                                      
REMARK 465     ILE E    96                                                      
REMARK 465     GLN E    97                                                      
REMARK 465     GLU E    98                                                      
REMARK 465     LEU E    99                                                      
REMARK 465     ILE E   100                                                      
REMARK 465     GLU E   101                                                      
REMARK 465     VAL E   102                                                      
REMARK 465     GLU E   103                                                      
REMARK 465     GLU E   104                                                      
REMARK 465     GLU E   105                                                      
REMARK 465     GLU E   106                                                      
REMARK 465     GLU E   107                                                      
REMARK 465     ILE E   108                                                      
REMARK 465     LEU E   109                                                      
REMARK 465     LEU E   110                                                      
REMARK 465     ASN E   111                                                      
REMARK 465     SER E   112                                                      
REMARK 465     TYR E   113                                                      
REMARK 465     THR E   114                                                      
REMARK 465     THR E   115                                                      
REMARK 465     PRO E   116                                                      
REMARK 465     SER E   117                                                      
REMARK 465     LYS E   118                                                      
REMARK 465     GLY E   119                                                      
REMARK 465     SER E   120                                                      
REMARK 465     GLN E   121                                                      
REMARK 465     LYS E   122                                                      
REMARK 465     ARG E   123                                                      
REMARK 465     ALA E   124                                                      
REMARK 465     ILE E   125                                                      
REMARK 465     SER E   126                                                      
REMARK 465     THR E   127                                                      
REMARK 465     PRO E   128                                                      
REMARK 465     GLU E   129                                                      
REMARK 465     THR E   130                                                      
REMARK 465     PRO E   131                                                      
REMARK 465     LEU E   132                                                      
REMARK 465     THR E   133                                                      
REMARK 465     LYS E   134                                                      
REMARK 465     ARG E   135                                                      
REMARK 465     SER E   136                                                      
REMARK 465     VAL E   137                                                      
REMARK 465     SER E   138                                                      
REMARK 465     THR E   139                                                      
REMARK 465     ARG E   140                                                      
REMARK 465     SER E   141                                                      
REMARK 465     PRO E   142                                                      
REMARK 465     HIS E   143                                                      
REMARK 465     GLN E   144                                                      
REMARK 465     LEU E   145                                                      
REMARK 465     LEU E   146                                                      
REMARK 465     SER E   147                                                      
REMARK 465     PRO E   148                                                      
REMARK 465     SER E   149                                                      
REMARK 465     SER E   150                                                      
REMARK 465     PHE E   151                                                      
REMARK 465     SER E   152                                                      
REMARK 465     PRO E   153                                                      
REMARK 465     SER E   154                                                      
REMARK 465     ALA E   155                                                      
REMARK 465     THR E   156                                                      
REMARK 465     SER E   489                                                      
REMARK 465     GLY E   490                                                      
REMARK 465     THR E   491                                                      
REMARK 465     ALA F  1265                                                      
REMARK 465     SER F  1442                                                      
REMARK 465     ARG F  1443                                                      
REMARK 465     SER F  1444                                                      
REMARK 465     MET G     1                                                      
REMARK 465     SER G     2                                                      
REMARK 465     ALA G     3                                                      
REMARK 465     SER G     4                                                      
REMARK 465     ALA G     5                                                      
REMARK 465     GLN G     6                                                      
REMARK 465     GLN G     7                                                      
REMARK 465     LEU G     8                                                      
REMARK 465     ALA G     9                                                      
REMARK 465     GLU G    10                                                      
REMARK 465     GLU G    11                                                      
REMARK 465     LEU G    12                                                      
REMARK 465     GLN G    13                                                      
REMARK 465     ILE G    14                                                      
REMARK 465     PHE G    15                                                      
REMARK 465     GLY G    16                                                      
REMARK 465     LEU G    17                                                      
REMARK 465     ASP G    18                                                      
REMARK 465     CYS G    19                                                      
REMARK 465     GLU G    20                                                      
REMARK 465     GLU G    21                                                      
REMARK 465     ALA G    22                                                      
REMARK 465     LEU G    23                                                      
REMARK 465     ILE G    24                                                      
REMARK 465     GLU G    25                                                      
REMARK 465     LYS G    26                                                      
REMARK 465     LEU G    27                                                      
REMARK 465     VAL G    28                                                      
REMARK 465     GLU G    29                                                      
REMARK 465     LEU G    30                                                      
REMARK 465     CYS G    31                                                      
REMARK 465     VAL G    32                                                      
REMARK 465     GLN G    33                                                      
REMARK 465     TYR G    34                                                      
REMARK 465     GLY G    35                                                      
REMARK 465     GLN G    36                                                      
REMARK 465     ASN G    37                                                      
REMARK 465     GLU G    38                                                      
REMARK 465     GLU G    39                                                      
REMARK 465     GLY G    40                                                      
REMARK 465     MET G    41                                                      
REMARK 465     VAL G    42                                                      
REMARK 465     GLY G    43                                                      
REMARK 465     GLU G    44                                                      
REMARK 465     LEU G    45                                                      
REMARK 465     ILE G    46                                                      
REMARK 465     ALA G    47                                                      
REMARK 465     PHE G    48                                                      
REMARK 465     CYS G    49                                                      
REMARK 465     THR G    50                                                      
REMARK 465     SER G    51                                                      
REMARK 465     THR G    52                                                      
REMARK 465     HIS G    53                                                      
REMARK 465     LYS G    54                                                      
REMARK 465     VAL G    55                                                      
REMARK 465     GLY G    56                                                      
REMARK 465     LEU G    57                                                      
REMARK 465     THR G    58                                                      
REMARK 465     SER G    59                                                      
REMARK 465     GLU G    60                                                      
REMARK 465     ILE G    61                                                      
REMARK 465     LEU G    62                                                      
REMARK 465     ASN G    63                                                      
REMARK 465     SER G    64                                                      
REMARK 465     PHE G    65                                                      
REMARK 465     GLU G    66                                                      
REMARK 465     HIS G    67                                                      
REMARK 465     GLU G    68                                                      
REMARK 465     PHE G    69                                                      
REMARK 465     LEU G    70                                                      
REMARK 465     SER G    71                                                      
REMARK 465     LYS G    72                                                      
REMARK 465     ARG G    73                                                      
REMARK 465     LEU G    74                                                      
REMARK 465     SER G    75                                                      
REMARK 465     LYS G    76                                                      
REMARK 465     ALA G    77                                                      
REMARK 465     ARG G    78                                                      
REMARK 465     HIS G    79                                                      
REMARK 465     SER G    80                                                      
REMARK 465     THR G    81                                                      
REMARK 465     CYS G    82                                                      
REMARK 465     LYS G    83                                                      
REMARK 465     ASP G    84                                                      
REMARK 465     SER G    85                                                      
REMARK 465     GLY G    86                                                      
REMARK 465     HIS G    87                                                      
REMARK 465     ALA G    88                                                      
REMARK 465     GLY G    89                                                      
REMARK 465     ALA G    90                                                      
REMARK 465     ARG G    91                                                      
REMARK 465     ASP G    92                                                      
REMARK 465     ILE G    93                                                      
REMARK 465     VAL G    94                                                      
REMARK 465     SER G    95                                                      
REMARK 465     ILE G    96                                                      
REMARK 465     GLN G    97                                                      
REMARK 465     GLU G    98                                                      
REMARK 465     LEU G    99                                                      
REMARK 465     ILE G   100                                                      
REMARK 465     GLU G   101                                                      
REMARK 465     VAL G   102                                                      
REMARK 465     GLU G   103                                                      
REMARK 465     GLU G   104                                                      
REMARK 465     GLU G   105                                                      
REMARK 465     GLU G   106                                                      
REMARK 465     GLU G   107                                                      
REMARK 465     ILE G   108                                                      
REMARK 465     LEU G   109                                                      
REMARK 465     LEU G   110                                                      
REMARK 465     ASN G   111                                                      
REMARK 465     SER G   112                                                      
REMARK 465     TYR G   113                                                      
REMARK 465     THR G   114                                                      
REMARK 465     THR G   115                                                      
REMARK 465     PRO G   116                                                      
REMARK 465     SER G   117                                                      
REMARK 465     LYS G   118                                                      
REMARK 465     GLY G   119                                                      
REMARK 465     SER G   120                                                      
REMARK 465     GLN G   121                                                      
REMARK 465     LYS G   122                                                      
REMARK 465     ARG G   123                                                      
REMARK 465     ALA G   124                                                      
REMARK 465     ILE G   125                                                      
REMARK 465     SER G   126                                                      
REMARK 465     THR G   127                                                      
REMARK 465     PRO G   128                                                      
REMARK 465     GLU G   129                                                      
REMARK 465     THR G   130                                                      
REMARK 465     PRO G   131                                                      
REMARK 465     LEU G   132                                                      
REMARK 465     THR G   133                                                      
REMARK 465     LYS G   134                                                      
REMARK 465     ARG G   135                                                      
REMARK 465     SER G   136                                                      
REMARK 465     VAL G   137                                                      
REMARK 465     SER G   138                                                      
REMARK 465     THR G   139                                                      
REMARK 465     ARG G   140                                                      
REMARK 465     SER G   141                                                      
REMARK 465     PRO G   142                                                      
REMARK 465     HIS G   143                                                      
REMARK 465     GLN G   144                                                      
REMARK 465     LEU G   145                                                      
REMARK 465     LEU G   146                                                      
REMARK 465     SER G   147                                                      
REMARK 465     PRO G   148                                                      
REMARK 465     SER G   149                                                      
REMARK 465     SER G   150                                                      
REMARK 465     PHE G   151                                                      
REMARK 465     SER G   152                                                      
REMARK 465     PRO G   153                                                      
REMARK 465     SER G   154                                                      
REMARK 465     ALA G   155                                                      
REMARK 465     THR G   156                                                      
REMARK 465     THR G   203                                                      
REMARK 465     GLY G   204                                                      
REMARK 465     SER G   205                                                      
REMARK 465     TYR G   206                                                      
REMARK 465     SER G   489                                                      
REMARK 465     GLY G   490                                                      
REMARK 465     ALA H  1265                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   C    THR C   156     CD   PRO C   157              1.76            
REMARK 500   O    PRO A   157     N    GLN A   159              1.97            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    GLN B1439   N   -  CA  -  C   ANGL. DEV. = -18.8 DEGREES          
REMARK 500    PRO C 153   C   -  N   -  CA  ANGL. DEV. =  12.6 DEGREES          
REMARK 500    PRO C 157   C   -  N   -  CA  ANGL. DEV. =  44.3 DEGREES          
REMARK 500    PRO C 157   C   -  N   -  CD  ANGL. DEV. = -52.4 DEGREES          
REMARK 500    PRO C 199   C   -  N   -  CA  ANGL. DEV. =  17.1 DEGREES          
REMARK 500    PRO C 199   C   -  N   -  CD  ANGL. DEV. = -16.8 DEGREES          
REMARK 500    GLU C 390   CA  -  CB  -  CG  ANGL. DEV. =  14.2 DEGREES          
REMARK 500    GLY G 197   N   -  CA  -  C   ANGL. DEV. =  17.5 DEGREES          
REMARK 500    CYS G 198   N   -  CA  -  C   ANGL. DEV. = -28.1 DEGREES          
REMARK 500    PRO G 199   C   -  N   -  CA  ANGL. DEV. =  26.2 DEGREES          
REMARK 500    PRO G 199   C   -  N   -  CD  ANGL. DEV. = -29.2 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER A 158       18.69    -10.02                                   
REMARK 500    ARG A 167      123.89    -25.10                                   
REMARK 500    ALA A 201       24.74   -143.75                                   
REMARK 500    ASN A 267        5.05    -60.65                                   
REMARK 500    TYR A 294      149.04   -170.36                                   
REMARK 500    GLU A 432      122.87    -38.00                                   
REMARK 500    ASP A 444       71.90    -67.45                                   
REMARK 500    SER A 446     -179.70    -68.16                                   
REMARK 500    SER A 487      118.90    179.14                                   
REMARK 500    SER A 488      -70.31   -156.15                                   
REMARK 500    SER A 489      -73.00   -156.87                                   
REMARK 500    TYR A 509       78.33   -159.86                                   
REMARK 500    ASP A 517        2.54    146.01                                   
REMARK 500    ARG A 577      107.34   -176.38                                   
REMARK 500    ALA A 581      -61.95    -25.80                                   
REMARK 500    ALA A 584       90.71    -57.67                                   
REMARK 500    GLU A 585      -90.10      1.83                                   
REMARK 500    ARG A 586      109.51    -49.82                                   
REMARK 500    THR B1285      -74.70    -94.97                                   
REMARK 500    ASP B1293       -2.93   -140.35                                   
REMARK 500    CYS B1353      -68.75   -105.56                                   
REMARK 500    SER B1365     -167.52   -104.89                                   
REMARK 500    ALA B1373      -77.98    -73.99                                   
REMARK 500    PRO C 153      148.16    -24.50                                   
REMARK 500    THR C 156      -73.15    -75.17                                   
REMARK 500    PRO C 157      119.98     34.10                                   
REMARK 500    ARG C 167      127.53    -28.28                                   
REMARK 500    LEU C 196     -159.59    -91.57                                   
REMARK 500    PRO C 199     -121.92      0.85                                   
REMARK 500    GLU C 200       98.87     95.25                                   
REMARK 500    ALA C 201       34.01   -156.77                                   
REMARK 500    ASN C 267        5.58    -61.83                                   
REMARK 500    GLU C 432      124.68    -39.61                                   
REMARK 500    ASP C 444       70.72    -67.62                                   
REMARK 500    SER C 446     -179.11    -69.07                                   
REMARK 500    TYR C 509       78.20   -160.18                                   
REMARK 500    GLU C 516       89.18    -69.85                                   
REMARK 500    ASP C 517        4.01    145.40                                   
REMARK 500    ARG C 577      109.84   -176.53                                   
REMARK 500    ALA C 581      -62.92    -24.92                                   
REMARK 500    ALA C 584       89.44    -57.38                                   
REMARK 500    GLU C 585      -91.52      4.71                                   
REMARK 500    ARG C 586      106.90    -45.72                                   
REMARK 500    THR D1285      -72.83    -95.96                                   
REMARK 500    CYS D1353      -69.63   -105.18                                   
REMARK 500    SER D1365     -168.36   -104.48                                   
REMARK 500    ALA D1373      -77.59    -74.20                                   
REMARK 500    ALA D1437      -74.43    -48.39                                   
REMARK 500    ARG E 167      124.93    -25.24                                   
REMARK 500    PRO E 199      148.28    -31.04                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      95 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    TYR E 522         0.07    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B1501  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B1283   SG                                                     
REMARK 620 2 CYS B1286   SG   92.5                                              
REMARK 620 3 CYS B1310   SG  139.9  97.7                                        
REMARK 620 4 CYS B1315   SG   94.8  87.7 124.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B1502  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B1348   SG                                                     
REMARK 620 2 CYS B1353   SG  110.8                                              
REMARK 620 3 CYS B1371   SG  113.6 106.5                                        
REMARK 620 4 CYS B1374   SG  107.0 111.5 107.4                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN D1501  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS D1283   SG                                                     
REMARK 620 2 CYS D1286   SG  113.1                                              
REMARK 620 3 CYS D1310   SG  110.8 106.9                                        
REMARK 620 4 CYS D1315   SG   96.3 116.7 112.9                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN D1502  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS D1348   SG                                                     
REMARK 620 2 CYS D1353   SG  115.2                                              
REMARK 620 3 CYS D1371   SG  109.7  99.3                                        
REMARK 620 4 CYS D1374   SG  108.6 110.7 113.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN F1501  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS F1283   SG                                                     
REMARK 620 2 CYS F1286   SG  115.1                                              
REMARK 620 3 CYS F1310   SG  101.1 104.0                                        
REMARK 620 4 CYS F1315   SG   98.2 131.5 102.8                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN F1502  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS F1348   SG                                                     
REMARK 620 2 CYS F1353   SG  120.0                                              
REMARK 620 3 CYS F1371   SG  108.3  99.9                                        
REMARK 620 4 CYS F1374   SG  104.1 116.7 106.9                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN H1501  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS H1283   SG                                                     
REMARK 620 2 CYS H1286   SG  125.6                                              
REMARK 620 3 CYS H1310   SG  105.2 104.4                                        
REMARK 620 4 CYS H1315   SG  104.6 122.8  84.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN H1502  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS H1348   SG                                                     
REMARK 620 2 CYS H1353   SG  121.3                                              
REMARK 620 3 CYS H1371   SG  119.5  98.3                                        
REMARK 620 4 CYS H1374   SG  110.2 106.9  97.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 1501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 1502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN D 1501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN D 1502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN F 1501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN F 1502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN H 1501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN H 1502                 
DBREF  4Y97 A    1   598  UNP    Q14181   DPOA2_HUMAN      1    598             
DBREF  4Y97 B 1265  1444  UNP    P09884   DPOLA_HUMAN   1265   1444             
DBREF  4Y97 C    1   598  UNP    Q14181   DPOA2_HUMAN      1    598             
DBREF  4Y97 D 1265  1444  UNP    P09884   DPOLA_HUMAN   1265   1444             
DBREF  4Y97 E    1   598  UNP    Q14181   DPOA2_HUMAN      1    598             
DBREF  4Y97 F 1265  1444  UNP    P09884   DPOLA_HUMAN   1265   1444             
DBREF  4Y97 G    1   598  UNP    Q14181   DPOA2_HUMAN      1    598             
DBREF  4Y97 H 1265  1444  UNP    P09884   DPOLA_HUMAN   1265   1444             
SEQRES   1 A  598  MET SER ALA SER ALA GLN GLN LEU ALA GLU GLU LEU GLN          
SEQRES   2 A  598  ILE PHE GLY LEU ASP CYS GLU GLU ALA LEU ILE GLU LYS          
SEQRES   3 A  598  LEU VAL GLU LEU CYS VAL GLN TYR GLY GLN ASN GLU GLU          
SEQRES   4 A  598  GLY MET VAL GLY GLU LEU ILE ALA PHE CYS THR SER THR          
SEQRES   5 A  598  HIS LYS VAL GLY LEU THR SER GLU ILE LEU ASN SER PHE          
SEQRES   6 A  598  GLU HIS GLU PHE LEU SER LYS ARG LEU SER LYS ALA ARG          
SEQRES   7 A  598  HIS SER THR CYS LYS ASP SER GLY HIS ALA GLY ALA ARG          
SEQRES   8 A  598  ASP ILE VAL SER ILE GLN GLU LEU ILE GLU VAL GLU GLU          
SEQRES   9 A  598  GLU GLU GLU ILE LEU LEU ASN SER TYR THR THR PRO SER          
SEQRES  10 A  598  LYS GLY SER GLN LYS ARG ALA ILE SER THR PRO GLU THR          
SEQRES  11 A  598  PRO LEU THR LYS ARG SER VAL SER THR ARG SER PRO HIS          
SEQRES  12 A  598  GLN LEU LEU SER PRO SER SER PHE SER PRO SER ALA THR          
SEQRES  13 A  598  PRO SER GLN LYS TYR ASN SER ARG SER ASN ARG GLY GLU          
SEQRES  14 A  598  VAL VAL THR SER PHE GLY LEU ALA GLN GLY VAL SER TRP          
SEQRES  15 A  598  SER GLY ARG GLY GLY ALA GLY ASN ILE SER LEU LYS VAL          
SEQRES  16 A  598  LEU GLY CYS PRO GLU ALA LEU THR GLY SER TYR LYS SER          
SEQRES  17 A  598  MET PHE GLN LYS LEU PRO ASP ILE ARG GLU VAL LEU THR          
SEQRES  18 A  598  CYS LYS ILE GLU GLU LEU GLY SER GLU LEU LYS GLU HIS          
SEQRES  19 A  598  TYR LYS ILE GLU ALA PHE THR PRO LEU LEU ALA PRO ALA          
SEQRES  20 A  598  GLN GLU PRO VAL THR LEU LEU GLY GLN ILE GLY CYS ASP          
SEQRES  21 A  598  SER ASN GLY LYS LEU ASN ASN LYS SER VAL ILE LEU GLU          
SEQRES  22 A  598  GLY ASP ARG GLU HIS SER SER GLY ALA GLN ILE PRO VAL          
SEQRES  23 A  598  ASP LEU SER GLU LEU LYS GLU TYR SER LEU PHE PRO GLY          
SEQRES  24 A  598  GLN VAL VAL ILE MET GLU GLY ILE ASN THR THR GLY ARG          
SEQRES  25 A  598  LYS LEU VAL ALA THR LYS LEU TYR GLU GLY VAL PRO LEU          
SEQRES  26 A  598  PRO PHE TYR GLN PRO THR GLU GLU ASP ALA ASP PHE GLU          
SEQRES  27 A  598  GLN SER MET VAL LEU VAL ALA CYS GLY PRO TYR THR THR          
SEQRES  28 A  598  SER ASP SER ILE THR TYR ASP PRO LEU LEU ASP LEU ILE          
SEQRES  29 A  598  ALA VAL ILE ASN HIS ASP ARG PRO ASP VAL CYS ILE LEU          
SEQRES  30 A  598  PHE GLY PRO PHE LEU ASP ALA LYS HIS GLU GLN VAL GLU          
SEQRES  31 A  598  ASN CYS LEU LEU THR SER PRO PHE GLU ASP ILE PHE LYS          
SEQRES  32 A  598  GLN CYS LEU ARG THR ILE ILE GLU GLY THR ARG SER SER          
SEQRES  33 A  598  GLY SER HIS LEU VAL PHE VAL PRO SER LEU ARG ASP VAL          
SEQRES  34 A  598  HIS HIS GLU PRO VAL TYR PRO GLN PRO PRO PHE SER TYR          
SEQRES  35 A  598  SER ASP LEU SER ARG GLU ASP LYS LYS GLN VAL GLN PHE          
SEQRES  36 A  598  VAL SER GLU PRO CYS SER LEU SER ILE ASN GLY VAL ILE          
SEQRES  37 A  598  PHE GLY LEU THR SER THR ASP LEU LEU PHE HIS LEU GLY          
SEQRES  38 A  598  ALA GLU GLU ILE SER SER SER SER GLY THR SER ASP ARG          
SEQRES  39 A  598  PHE SER ARG ILE LEU LYS HIS ILE LEU THR GLN ARG SER          
SEQRES  40 A  598  TYR TYR PRO LEU TYR PRO PRO GLN GLU ASP MET ALA ILE          
SEQRES  41 A  598  ASP TYR GLU SER PHE TYR VAL TYR ALA GLN LEU PRO VAL          
SEQRES  42 A  598  THR PRO ASP VAL LEU ILE ILE PRO SER GLU LEU ARG TYR          
SEQRES  43 A  598  PHE VAL LYS ASP VAL LEU GLY CYS VAL CYS VAL ASN PRO          
SEQRES  44 A  598  GLY ARG LEU THR LYS GLY GLN VAL GLY GLY THR PHE ALA          
SEQRES  45 A  598  ARG LEU TYR LEU ARG ARG PRO ALA ALA ASP GLY ALA GLU          
SEQRES  46 A  598  ARG GLN SER PRO CYS ILE ALA VAL GLN VAL VAL ARG ILE          
SEQRES   1 B  180  ALA GLN LEU THR ASP GLU GLU LYS TYR ARG ASP CYS GLU          
SEQRES   2 B  180  ARG PHE LYS CYS PRO CYS PRO THR CYS GLY THR GLU ASN          
SEQRES   3 B  180  ILE TYR ASP ASN VAL PHE ASP GLY SER GLY THR ASP MET          
SEQRES   4 B  180  GLU PRO SER LEU TYR ARG CYS SER ASN ILE ASP CYS LYS          
SEQRES   5 B  180  ALA SER PRO LEU THR PHE THR VAL GLN LEU SER ASN LYS          
SEQRES   6 B  180  LEU ILE MET ASP ILE ARG ARG PHE ILE LYS LYS TYR TYR          
SEQRES   7 B  180  ASP GLY TRP LEU ILE CYS GLU GLU PRO THR CYS ARG ASN          
SEQRES   8 B  180  ARG THR ARG HIS LEU PRO LEU GLN PHE SER ARG THR GLY          
SEQRES   9 B  180  PRO LEU CYS PRO ALA CYS MET LYS ALA THR LEU GLN PRO          
SEQRES  10 B  180  GLU TYR SER ASP LYS SER LEU TYR THR GLN LEU CYS PHE          
SEQRES  11 B  180  TYR ARG TYR ILE PHE ASP ALA GLU CYS ALA LEU GLU LYS          
SEQRES  12 B  180  LEU THR THR ASP HIS GLU LYS ASP LYS LEU LYS LYS GLN          
SEQRES  13 B  180  PHE PHE THR PRO LYS VAL LEU GLN ASP TYR ARG LYS LEU          
SEQRES  14 B  180  LYS ASN THR ALA GLU GLN PHE LEU SER ARG SER                  
SEQRES   1 C  598  MET SER ALA SER ALA GLN GLN LEU ALA GLU GLU LEU GLN          
SEQRES   2 C  598  ILE PHE GLY LEU ASP CYS GLU GLU ALA LEU ILE GLU LYS          
SEQRES   3 C  598  LEU VAL GLU LEU CYS VAL GLN TYR GLY GLN ASN GLU GLU          
SEQRES   4 C  598  GLY MET VAL GLY GLU LEU ILE ALA PHE CYS THR SER THR          
SEQRES   5 C  598  HIS LYS VAL GLY LEU THR SER GLU ILE LEU ASN SER PHE          
SEQRES   6 C  598  GLU HIS GLU PHE LEU SER LYS ARG LEU SER LYS ALA ARG          
SEQRES   7 C  598  HIS SER THR CYS LYS ASP SER GLY HIS ALA GLY ALA ARG          
SEQRES   8 C  598  ASP ILE VAL SER ILE GLN GLU LEU ILE GLU VAL GLU GLU          
SEQRES   9 C  598  GLU GLU GLU ILE LEU LEU ASN SER TYR THR THR PRO SER          
SEQRES  10 C  598  LYS GLY SER GLN LYS ARG ALA ILE SER THR PRO GLU THR          
SEQRES  11 C  598  PRO LEU THR LYS ARG SER VAL SER THR ARG SER PRO HIS          
SEQRES  12 C  598  GLN LEU LEU SER PRO SER SER PHE SER PRO SER ALA THR          
SEQRES  13 C  598  PRO SER GLN LYS TYR ASN SER ARG SER ASN ARG GLY GLU          
SEQRES  14 C  598  VAL VAL THR SER PHE GLY LEU ALA GLN GLY VAL SER TRP          
SEQRES  15 C  598  SER GLY ARG GLY GLY ALA GLY ASN ILE SER LEU LYS VAL          
SEQRES  16 C  598  LEU GLY CYS PRO GLU ALA LEU THR GLY SER TYR LYS SER          
SEQRES  17 C  598  MET PHE GLN LYS LEU PRO ASP ILE ARG GLU VAL LEU THR          
SEQRES  18 C  598  CYS LYS ILE GLU GLU LEU GLY SER GLU LEU LYS GLU HIS          
SEQRES  19 C  598  TYR LYS ILE GLU ALA PHE THR PRO LEU LEU ALA PRO ALA          
SEQRES  20 C  598  GLN GLU PRO VAL THR LEU LEU GLY GLN ILE GLY CYS ASP          
SEQRES  21 C  598  SER ASN GLY LYS LEU ASN ASN LYS SER VAL ILE LEU GLU          
SEQRES  22 C  598  GLY ASP ARG GLU HIS SER SER GLY ALA GLN ILE PRO VAL          
SEQRES  23 C  598  ASP LEU SER GLU LEU LYS GLU TYR SER LEU PHE PRO GLY          
SEQRES  24 C  598  GLN VAL VAL ILE MET GLU GLY ILE ASN THR THR GLY ARG          
SEQRES  25 C  598  LYS LEU VAL ALA THR LYS LEU TYR GLU GLY VAL PRO LEU          
SEQRES  26 C  598  PRO PHE TYR GLN PRO THR GLU GLU ASP ALA ASP PHE GLU          
SEQRES  27 C  598  GLN SER MET VAL LEU VAL ALA CYS GLY PRO TYR THR THR          
SEQRES  28 C  598  SER ASP SER ILE THR TYR ASP PRO LEU LEU ASP LEU ILE          
SEQRES  29 C  598  ALA VAL ILE ASN HIS ASP ARG PRO ASP VAL CYS ILE LEU          
SEQRES  30 C  598  PHE GLY PRO PHE LEU ASP ALA LYS HIS GLU GLN VAL GLU          
SEQRES  31 C  598  ASN CYS LEU LEU THR SER PRO PHE GLU ASP ILE PHE LYS          
SEQRES  32 C  598  GLN CYS LEU ARG THR ILE ILE GLU GLY THR ARG SER SER          
SEQRES  33 C  598  GLY SER HIS LEU VAL PHE VAL PRO SER LEU ARG ASP VAL          
SEQRES  34 C  598  HIS HIS GLU PRO VAL TYR PRO GLN PRO PRO PHE SER TYR          
SEQRES  35 C  598  SER ASP LEU SER ARG GLU ASP LYS LYS GLN VAL GLN PHE          
SEQRES  36 C  598  VAL SER GLU PRO CYS SER LEU SER ILE ASN GLY VAL ILE          
SEQRES  37 C  598  PHE GLY LEU THR SER THR ASP LEU LEU PHE HIS LEU GLY          
SEQRES  38 C  598  ALA GLU GLU ILE SER SER SER SER GLY THR SER ASP ARG          
SEQRES  39 C  598  PHE SER ARG ILE LEU LYS HIS ILE LEU THR GLN ARG SER          
SEQRES  40 C  598  TYR TYR PRO LEU TYR PRO PRO GLN GLU ASP MET ALA ILE          
SEQRES  41 C  598  ASP TYR GLU SER PHE TYR VAL TYR ALA GLN LEU PRO VAL          
SEQRES  42 C  598  THR PRO ASP VAL LEU ILE ILE PRO SER GLU LEU ARG TYR          
SEQRES  43 C  598  PHE VAL LYS ASP VAL LEU GLY CYS VAL CYS VAL ASN PRO          
SEQRES  44 C  598  GLY ARG LEU THR LYS GLY GLN VAL GLY GLY THR PHE ALA          
SEQRES  45 C  598  ARG LEU TYR LEU ARG ARG PRO ALA ALA ASP GLY ALA GLU          
SEQRES  46 C  598  ARG GLN SER PRO CYS ILE ALA VAL GLN VAL VAL ARG ILE          
SEQRES   1 D  180  ALA GLN LEU THR ASP GLU GLU LYS TYR ARG ASP CYS GLU          
SEQRES   2 D  180  ARG PHE LYS CYS PRO CYS PRO THR CYS GLY THR GLU ASN          
SEQRES   3 D  180  ILE TYR ASP ASN VAL PHE ASP GLY SER GLY THR ASP MET          
SEQRES   4 D  180  GLU PRO SER LEU TYR ARG CYS SER ASN ILE ASP CYS LYS          
SEQRES   5 D  180  ALA SER PRO LEU THR PHE THR VAL GLN LEU SER ASN LYS          
SEQRES   6 D  180  LEU ILE MET ASP ILE ARG ARG PHE ILE LYS LYS TYR TYR          
SEQRES   7 D  180  ASP GLY TRP LEU ILE CYS GLU GLU PRO THR CYS ARG ASN          
SEQRES   8 D  180  ARG THR ARG HIS LEU PRO LEU GLN PHE SER ARG THR GLY          
SEQRES   9 D  180  PRO LEU CYS PRO ALA CYS MET LYS ALA THR LEU GLN PRO          
SEQRES  10 D  180  GLU TYR SER ASP LYS SER LEU TYR THR GLN LEU CYS PHE          
SEQRES  11 D  180  TYR ARG TYR ILE PHE ASP ALA GLU CYS ALA LEU GLU LYS          
SEQRES  12 D  180  LEU THR THR ASP HIS GLU LYS ASP LYS LEU LYS LYS GLN          
SEQRES  13 D  180  PHE PHE THR PRO LYS VAL LEU GLN ASP TYR ARG LYS LEU          
SEQRES  14 D  180  LYS ASN THR ALA GLU GLN PHE LEU SER ARG SER                  
SEQRES   1 E  598  MET SER ALA SER ALA GLN GLN LEU ALA GLU GLU LEU GLN          
SEQRES   2 E  598  ILE PHE GLY LEU ASP CYS GLU GLU ALA LEU ILE GLU LYS          
SEQRES   3 E  598  LEU VAL GLU LEU CYS VAL GLN TYR GLY GLN ASN GLU GLU          
SEQRES   4 E  598  GLY MET VAL GLY GLU LEU ILE ALA PHE CYS THR SER THR          
SEQRES   5 E  598  HIS LYS VAL GLY LEU THR SER GLU ILE LEU ASN SER PHE          
SEQRES   6 E  598  GLU HIS GLU PHE LEU SER LYS ARG LEU SER LYS ALA ARG          
SEQRES   7 E  598  HIS SER THR CYS LYS ASP SER GLY HIS ALA GLY ALA ARG          
SEQRES   8 E  598  ASP ILE VAL SER ILE GLN GLU LEU ILE GLU VAL GLU GLU          
SEQRES   9 E  598  GLU GLU GLU ILE LEU LEU ASN SER TYR THR THR PRO SER          
SEQRES  10 E  598  LYS GLY SER GLN LYS ARG ALA ILE SER THR PRO GLU THR          
SEQRES  11 E  598  PRO LEU THR LYS ARG SER VAL SER THR ARG SER PRO HIS          
SEQRES  12 E  598  GLN LEU LEU SER PRO SER SER PHE SER PRO SER ALA THR          
SEQRES  13 E  598  PRO SER GLN LYS TYR ASN SER ARG SER ASN ARG GLY GLU          
SEQRES  14 E  598  VAL VAL THR SER PHE GLY LEU ALA GLN GLY VAL SER TRP          
SEQRES  15 E  598  SER GLY ARG GLY GLY ALA GLY ASN ILE SER LEU LYS VAL          
SEQRES  16 E  598  LEU GLY CYS PRO GLU ALA LEU THR GLY SER TYR LYS SER          
SEQRES  17 E  598  MET PHE GLN LYS LEU PRO ASP ILE ARG GLU VAL LEU THR          
SEQRES  18 E  598  CYS LYS ILE GLU GLU LEU GLY SER GLU LEU LYS GLU HIS          
SEQRES  19 E  598  TYR LYS ILE GLU ALA PHE THR PRO LEU LEU ALA PRO ALA          
SEQRES  20 E  598  GLN GLU PRO VAL THR LEU LEU GLY GLN ILE GLY CYS ASP          
SEQRES  21 E  598  SER ASN GLY LYS LEU ASN ASN LYS SER VAL ILE LEU GLU          
SEQRES  22 E  598  GLY ASP ARG GLU HIS SER SER GLY ALA GLN ILE PRO VAL          
SEQRES  23 E  598  ASP LEU SER GLU LEU LYS GLU TYR SER LEU PHE PRO GLY          
SEQRES  24 E  598  GLN VAL VAL ILE MET GLU GLY ILE ASN THR THR GLY ARG          
SEQRES  25 E  598  LYS LEU VAL ALA THR LYS LEU TYR GLU GLY VAL PRO LEU          
SEQRES  26 E  598  PRO PHE TYR GLN PRO THR GLU GLU ASP ALA ASP PHE GLU          
SEQRES  27 E  598  GLN SER MET VAL LEU VAL ALA CYS GLY PRO TYR THR THR          
SEQRES  28 E  598  SER ASP SER ILE THR TYR ASP PRO LEU LEU ASP LEU ILE          
SEQRES  29 E  598  ALA VAL ILE ASN HIS ASP ARG PRO ASP VAL CYS ILE LEU          
SEQRES  30 E  598  PHE GLY PRO PHE LEU ASP ALA LYS HIS GLU GLN VAL GLU          
SEQRES  31 E  598  ASN CYS LEU LEU THR SER PRO PHE GLU ASP ILE PHE LYS          
SEQRES  32 E  598  GLN CYS LEU ARG THR ILE ILE GLU GLY THR ARG SER SER          
SEQRES  33 E  598  GLY SER HIS LEU VAL PHE VAL PRO SER LEU ARG ASP VAL          
SEQRES  34 E  598  HIS HIS GLU PRO VAL TYR PRO GLN PRO PRO PHE SER TYR          
SEQRES  35 E  598  SER ASP LEU SER ARG GLU ASP LYS LYS GLN VAL GLN PHE          
SEQRES  36 E  598  VAL SER GLU PRO CYS SER LEU SER ILE ASN GLY VAL ILE          
SEQRES  37 E  598  PHE GLY LEU THR SER THR ASP LEU LEU PHE HIS LEU GLY          
SEQRES  38 E  598  ALA GLU GLU ILE SER SER SER SER GLY THR SER ASP ARG          
SEQRES  39 E  598  PHE SER ARG ILE LEU LYS HIS ILE LEU THR GLN ARG SER          
SEQRES  40 E  598  TYR TYR PRO LEU TYR PRO PRO GLN GLU ASP MET ALA ILE          
SEQRES  41 E  598  ASP TYR GLU SER PHE TYR VAL TYR ALA GLN LEU PRO VAL          
SEQRES  42 E  598  THR PRO ASP VAL LEU ILE ILE PRO SER GLU LEU ARG TYR          
SEQRES  43 E  598  PHE VAL LYS ASP VAL LEU GLY CYS VAL CYS VAL ASN PRO          
SEQRES  44 E  598  GLY ARG LEU THR LYS GLY GLN VAL GLY GLY THR PHE ALA          
SEQRES  45 E  598  ARG LEU TYR LEU ARG ARG PRO ALA ALA ASP GLY ALA GLU          
SEQRES  46 E  598  ARG GLN SER PRO CYS ILE ALA VAL GLN VAL VAL ARG ILE          
SEQRES   1 F  180  ALA GLN LEU THR ASP GLU GLU LYS TYR ARG ASP CYS GLU          
SEQRES   2 F  180  ARG PHE LYS CYS PRO CYS PRO THR CYS GLY THR GLU ASN          
SEQRES   3 F  180  ILE TYR ASP ASN VAL PHE ASP GLY SER GLY THR ASP MET          
SEQRES   4 F  180  GLU PRO SER LEU TYR ARG CYS SER ASN ILE ASP CYS LYS          
SEQRES   5 F  180  ALA SER PRO LEU THR PHE THR VAL GLN LEU SER ASN LYS          
SEQRES   6 F  180  LEU ILE MET ASP ILE ARG ARG PHE ILE LYS LYS TYR TYR          
SEQRES   7 F  180  ASP GLY TRP LEU ILE CYS GLU GLU PRO THR CYS ARG ASN          
SEQRES   8 F  180  ARG THR ARG HIS LEU PRO LEU GLN PHE SER ARG THR GLY          
SEQRES   9 F  180  PRO LEU CYS PRO ALA CYS MET LYS ALA THR LEU GLN PRO          
SEQRES  10 F  180  GLU TYR SER ASP LYS SER LEU TYR THR GLN LEU CYS PHE          
SEQRES  11 F  180  TYR ARG TYR ILE PHE ASP ALA GLU CYS ALA LEU GLU LYS          
SEQRES  12 F  180  LEU THR THR ASP HIS GLU LYS ASP LYS LEU LYS LYS GLN          
SEQRES  13 F  180  PHE PHE THR PRO LYS VAL LEU GLN ASP TYR ARG LYS LEU          
SEQRES  14 F  180  LYS ASN THR ALA GLU GLN PHE LEU SER ARG SER                  
SEQRES   1 G  598  MET SER ALA SER ALA GLN GLN LEU ALA GLU GLU LEU GLN          
SEQRES   2 G  598  ILE PHE GLY LEU ASP CYS GLU GLU ALA LEU ILE GLU LYS          
SEQRES   3 G  598  LEU VAL GLU LEU CYS VAL GLN TYR GLY GLN ASN GLU GLU          
SEQRES   4 G  598  GLY MET VAL GLY GLU LEU ILE ALA PHE CYS THR SER THR          
SEQRES   5 G  598  HIS LYS VAL GLY LEU THR SER GLU ILE LEU ASN SER PHE          
SEQRES   6 G  598  GLU HIS GLU PHE LEU SER LYS ARG LEU SER LYS ALA ARG          
SEQRES   7 G  598  HIS SER THR CYS LYS ASP SER GLY HIS ALA GLY ALA ARG          
SEQRES   8 G  598  ASP ILE VAL SER ILE GLN GLU LEU ILE GLU VAL GLU GLU          
SEQRES   9 G  598  GLU GLU GLU ILE LEU LEU ASN SER TYR THR THR PRO SER          
SEQRES  10 G  598  LYS GLY SER GLN LYS ARG ALA ILE SER THR PRO GLU THR          
SEQRES  11 G  598  PRO LEU THR LYS ARG SER VAL SER THR ARG SER PRO HIS          
SEQRES  12 G  598  GLN LEU LEU SER PRO SER SER PHE SER PRO SER ALA THR          
SEQRES  13 G  598  PRO SER GLN LYS TYR ASN SER ARG SER ASN ARG GLY GLU          
SEQRES  14 G  598  VAL VAL THR SER PHE GLY LEU ALA GLN GLY VAL SER TRP          
SEQRES  15 G  598  SER GLY ARG GLY GLY ALA GLY ASN ILE SER LEU LYS VAL          
SEQRES  16 G  598  LEU GLY CYS PRO GLU ALA LEU THR GLY SER TYR LYS SER          
SEQRES  17 G  598  MET PHE GLN LYS LEU PRO ASP ILE ARG GLU VAL LEU THR          
SEQRES  18 G  598  CYS LYS ILE GLU GLU LEU GLY SER GLU LEU LYS GLU HIS          
SEQRES  19 G  598  TYR LYS ILE GLU ALA PHE THR PRO LEU LEU ALA PRO ALA          
SEQRES  20 G  598  GLN GLU PRO VAL THR LEU LEU GLY GLN ILE GLY CYS ASP          
SEQRES  21 G  598  SER ASN GLY LYS LEU ASN ASN LYS SER VAL ILE LEU GLU          
SEQRES  22 G  598  GLY ASP ARG GLU HIS SER SER GLY ALA GLN ILE PRO VAL          
SEQRES  23 G  598  ASP LEU SER GLU LEU LYS GLU TYR SER LEU PHE PRO GLY          
SEQRES  24 G  598  GLN VAL VAL ILE MET GLU GLY ILE ASN THR THR GLY ARG          
SEQRES  25 G  598  LYS LEU VAL ALA THR LYS LEU TYR GLU GLY VAL PRO LEU          
SEQRES  26 G  598  PRO PHE TYR GLN PRO THR GLU GLU ASP ALA ASP PHE GLU          
SEQRES  27 G  598  GLN SER MET VAL LEU VAL ALA CYS GLY PRO TYR THR THR          
SEQRES  28 G  598  SER ASP SER ILE THR TYR ASP PRO LEU LEU ASP LEU ILE          
SEQRES  29 G  598  ALA VAL ILE ASN HIS ASP ARG PRO ASP VAL CYS ILE LEU          
SEQRES  30 G  598  PHE GLY PRO PHE LEU ASP ALA LYS HIS GLU GLN VAL GLU          
SEQRES  31 G  598  ASN CYS LEU LEU THR SER PRO PHE GLU ASP ILE PHE LYS          
SEQRES  32 G  598  GLN CYS LEU ARG THR ILE ILE GLU GLY THR ARG SER SER          
SEQRES  33 G  598  GLY SER HIS LEU VAL PHE VAL PRO SER LEU ARG ASP VAL          
SEQRES  34 G  598  HIS HIS GLU PRO VAL TYR PRO GLN PRO PRO PHE SER TYR          
SEQRES  35 G  598  SER ASP LEU SER ARG GLU ASP LYS LYS GLN VAL GLN PHE          
SEQRES  36 G  598  VAL SER GLU PRO CYS SER LEU SER ILE ASN GLY VAL ILE          
SEQRES  37 G  598  PHE GLY LEU THR SER THR ASP LEU LEU PHE HIS LEU GLY          
SEQRES  38 G  598  ALA GLU GLU ILE SER SER SER SER GLY THR SER ASP ARG          
SEQRES  39 G  598  PHE SER ARG ILE LEU LYS HIS ILE LEU THR GLN ARG SER          
SEQRES  40 G  598  TYR TYR PRO LEU TYR PRO PRO GLN GLU ASP MET ALA ILE          
SEQRES  41 G  598  ASP TYR GLU SER PHE TYR VAL TYR ALA GLN LEU PRO VAL          
SEQRES  42 G  598  THR PRO ASP VAL LEU ILE ILE PRO SER GLU LEU ARG TYR          
SEQRES  43 G  598  PHE VAL LYS ASP VAL LEU GLY CYS VAL CYS VAL ASN PRO          
SEQRES  44 G  598  GLY ARG LEU THR LYS GLY GLN VAL GLY GLY THR PHE ALA          
SEQRES  45 G  598  ARG LEU TYR LEU ARG ARG PRO ALA ALA ASP GLY ALA GLU          
SEQRES  46 G  598  ARG GLN SER PRO CYS ILE ALA VAL GLN VAL VAL ARG ILE          
SEQRES   1 H  180  ALA GLN LEU THR ASP GLU GLU LYS TYR ARG ASP CYS GLU          
SEQRES   2 H  180  ARG PHE LYS CYS PRO CYS PRO THR CYS GLY THR GLU ASN          
SEQRES   3 H  180  ILE TYR ASP ASN VAL PHE ASP GLY SER GLY THR ASP MET          
SEQRES   4 H  180  GLU PRO SER LEU TYR ARG CYS SER ASN ILE ASP CYS LYS          
SEQRES   5 H  180  ALA SER PRO LEU THR PHE THR VAL GLN LEU SER ASN LYS          
SEQRES   6 H  180  LEU ILE MET ASP ILE ARG ARG PHE ILE LYS LYS TYR TYR          
SEQRES   7 H  180  ASP GLY TRP LEU ILE CYS GLU GLU PRO THR CYS ARG ASN          
SEQRES   8 H  180  ARG THR ARG HIS LEU PRO LEU GLN PHE SER ARG THR GLY          
SEQRES   9 H  180  PRO LEU CYS PRO ALA CYS MET LYS ALA THR LEU GLN PRO          
SEQRES  10 H  180  GLU TYR SER ASP LYS SER LEU TYR THR GLN LEU CYS PHE          
SEQRES  11 H  180  TYR ARG TYR ILE PHE ASP ALA GLU CYS ALA LEU GLU LYS          
SEQRES  12 H  180  LEU THR THR ASP HIS GLU LYS ASP LYS LEU LYS LYS GLN          
SEQRES  13 H  180  PHE PHE THR PRO LYS VAL LEU GLN ASP TYR ARG LYS LEU          
SEQRES  14 H  180  LYS ASN THR ALA GLU GLN PHE LEU SER ARG SER                  
HET     ZN  B1501       1                                                       
HET     ZN  B1502       1                                                       
HET     ZN  D1501       1                                                       
HET     ZN  D1502       1                                                       
HET     ZN  F1501       1                                                       
HET     ZN  F1502       1                                                       
HET     ZN  H1501       1                                                       
HET     ZN  H1502       1                                                       
HETNAM      ZN ZINC ION                                                         
FORMUL   9   ZN    8(ZN 2+)                                                     
FORMUL  17  HOH   *202(H2 O)                                                    
HELIX    1 AA1 SER A  158  SER A  163  1                                   6    
HELIX    2 AA2 LYS A  212  TYR A  235  1                                  24    
HELIX    3 AA3 ASP A  275  SER A  280  1                                   6    
HELIX    4 AA4 GLU A  332  PHE A  337  5                                   6    
HELIX    5 AA5 TYR A  357  ARG A  371  1                                  15    
HELIX    6 AA6 HIS A  386  ASN A  391  1                                   6    
HELIX    7 AA7 PRO A  397  THR A  413  1                                  17    
HELIX    8 AA8 ARG A  414  GLY A  417  5                                   4    
HELIX    9 AA9 GLU A  448  LYS A  451  5                                   4    
HELIX   10 AB1 ASP A  475  ALA A  482  1                                   8    
HELIX   11 AB2 ASP A  493  ARG A  506  1                                  14    
HELIX   12 AB3 ASP A  521  ALA A  529  1                                   9    
HELIX   13 AB4 ASP B 1269  TYR B 1273  1                                   5    
HELIX   14 AB5 SER B 1318  THR B 1321  5                                   4    
HELIX   15 AB6 PHE B 1322  ASP B 1343  1                                  22    
HELIX   16 AB7 SER B 1384  ILE B 1398  1                                  15    
HELIX   17 AB8 ASP B 1400  LYS B 1407  1                                   8    
HELIX   18 AB9 THR B 1410  PHE B 1421  1                                  12    
HELIX   19 AC1 THR B 1423  ASN B 1435  1                                  13    
HELIX   20 AC2 SER C  158  SER C  163  1                                   6    
HELIX   21 AC3 LYS C  212  TYR C  235  1                                  24    
HELIX   22 AC4 ASP C  275  SER C  280  1                                   6    
HELIX   23 AC5 GLU C  332  PHE C  337  5                                   6    
HELIX   24 AC6 TYR C  357  ARG C  371  1                                  15    
HELIX   25 AC7 HIS C  386  ASN C  391  1                                   6    
HELIX   26 AC8 PRO C  397  THR C  413  1                                  17    
HELIX   27 AC9 GLU C  448  LYS C  451  5                                   4    
HELIX   28 AD1 ASP C  475  ALA C  482  1                                   8    
HELIX   29 AD2 ASP C  493  ARG C  506  1                                  14    
HELIX   30 AD3 ASP C  521  ALA C  529  1                                   9    
HELIX   31 AD4 THR D 1268  TYR D 1273  1                                   6    
HELIX   32 AD5 SER D 1318  THR D 1321  5                                   4    
HELIX   33 AD6 PHE D 1322  ASP D 1343  1                                  22    
HELIX   34 AD7 SER D 1384  ILE D 1398  1                                  15    
HELIX   35 AD8 ASP D 1400  LYS D 1407  1                                   8    
HELIX   36 AD9 THR D 1410  PHE D 1421  1                                  12    
HELIX   37 AE1 THR D 1423  ASN D 1435  1                                  13    
HELIX   38 AE2 ASN D 1435  PHE D 1440  1                                   6    
HELIX   39 AE3 SER E  158  SER E  163  1                                   6    
HELIX   40 AE4 LYS E  212  TYR E  235  1                                  24    
HELIX   41 AE5 ASP E  275  SER E  280  1                                   6    
HELIX   42 AE6 GLU E  332  PHE E  337  5                                   6    
HELIX   43 AE7 TYR E  357  ARG E  371  1                                  15    
HELIX   44 AE8 HIS E  386  ASN E  391  1                                   6    
HELIX   45 AE9 PRO E  397  THR E  413  1                                  17    
HELIX   46 AF1 ARG E  414  GLY E  417  5                                   4    
HELIX   47 AF2 GLU E  448  LYS E  451  5                                   4    
HELIX   48 AF3 ASP E  475  ALA E  482  1                                   8    
HELIX   49 AF4 ASP E  493  ARG E  506  1                                  14    
HELIX   50 AF5 ASP E  521  ALA E  529  1                                   9    
HELIX   51 AF6 THR F 1268  TYR F 1273  1                                   6    
HELIX   52 AF7 SER F 1318  THR F 1321  5                                   4    
HELIX   53 AF8 PHE F 1322  ASP F 1343  1                                  22    
HELIX   54 AF9 SER F 1384  ILE F 1398  1                                  15    
HELIX   55 AG1 ASP F 1400  LYS F 1407  1                                   8    
HELIX   56 AG2 THR F 1410  PHE F 1421  1                                  12    
HELIX   57 AG3 THR F 1423  ASN F 1435  1                                  13    
HELIX   58 AG4 SER G  158  SER G  163  1                                   6    
HELIX   59 AG5 LYS G  212  TYR G  235  1                                  24    
HELIX   60 AG6 ASP G  275  SER G  280  1                                   6    
HELIX   61 AG7 GLU G  332  PHE G  337  5                                   6    
HELIX   62 AG8 TYR G  357  ARG G  371  1                                  15    
HELIX   63 AG9 HIS G  386  ASN G  391  1                                   6    
HELIX   64 AH1 PRO G  397  THR G  413  1                                  17    
HELIX   65 AH2 ARG G  414  GLY G  417  5                                   4    
HELIX   66 AH3 GLU G  448  GLN G  452  1                                   5    
HELIX   67 AH4 ASP G  475  ALA G  482  1                                   8    
HELIX   68 AH5 ASP G  493  ARG G  506  1                                  14    
HELIX   69 AH6 ASP G  521  ALA G  529  1                                   9    
HELIX   70 AH7 THR H 1268  TYR H 1273  1                                   6    
HELIX   71 AH8 SER H 1318  THR H 1321  5                                   4    
HELIX   72 AH9 PHE H 1322  ASP H 1343  1                                  22    
HELIX   73 AI1 SER H 1384  ILE H 1398  1                                  15    
HELIX   74 AI2 ASP H 1400  LYS H 1407  1                                   8    
HELIX   75 AI3 THR H 1410  PHE H 1421  1                                  12    
HELIX   76 AI4 THR H 1423  ASN H 1435  1                                  13    
HELIX   77 AI5 ASN H 1435  PHE H 1440  1                                   6    
SHEET    1 AA1 7 VAL A 170  GLY A 175  0                                        
SHEET    2 AA1 7 CYS A 590  ARG A 597 -1  O  VAL A 593   N  PHE A 174           
SHEET    3 AA1 7 THR A 570  LEU A 576 -1  N  ARG A 573   O  GLN A 594           
SHEET    4 AA1 7 SER A 340  CYS A 346 -1  N  VAL A 344   O  ALA A 572           
SHEET    5 AA1 7 VAL A 374  PHE A 378  1  O  VAL A 374   N  LEU A 343           
SHEET    6 AA1 7 HIS A 419  VAL A 423  1  O  VAL A 421   N  CYS A 375           
SHEET    7 AA1 7 VAL A 453  PHE A 455  1  O  GLN A 454   N  PHE A 422           
SHEET    1 AA2 6 LEU A 193  VAL A 195  0                                        
SHEET    2 AA2 6 CYS A 460  ILE A 464 -1  O  SER A 463   N  LYS A 194           
SHEET    3 AA2 6 VAL A 467  LEU A 471 -1  O  PHE A 469   N  LEU A 462           
SHEET    4 AA2 6 VAL A 537  ILE A 539  1  O  ILE A 539   N  GLY A 470           
SHEET    5 AA2 6 CYS A 554  ASN A 558  1  O  VAL A 557   N  LEU A 538           
SHEET    6 AA2 6 PHE A 547  VAL A 551 -1  N  LYS A 549   O  CYS A 556           
SHEET    1 AA3 6 VAL A 251  CYS A 259  0                                        
SHEET    2 AA3 6 VAL A 270  GLY A 274 -1  O  GLU A 273   N  GLN A 256           
SHEET    3 AA3 6 GLN A 283  ASP A 287 -1  O  ILE A 284   N  LEU A 272           
SHEET    4 AA3 6 LEU A 314  LEU A 319  1  O  LEU A 314   N  ASP A 287           
SHEET    5 AA3 6 VAL A 301  ILE A 307 -1  N  GLU A 305   O  THR A 317           
SHEET    6 AA3 6 VAL A 251  CYS A 259 -1  N  LEU A 253   O  MET A 304           
SHEET    1 AA4 2 TYR A 294  LEU A 296  0                                        
SHEET    2 AA4 2 ILE A 485  SER A 487 -1  O  ILE A 485   N  LEU A 296           
SHEET    1 AA5 2 THR A 563  LYS A 564  0                                        
SHEET    2 AA5 2 VAL A 567  GLY A 568 -1  O  VAL A 567   N  LYS A 564           
SHEET    1 AA6 2 PHE B1279  PRO B1282  0                                        
SHEET    2 AA6 2 GLU B1289  TYR B1292 -1  O  TYR B1292   N  PHE B1279           
SHEET    1 AA7 2 PHE B1296  ASP B1297  0                                        
SHEET    2 AA7 2 GLU B1304  PRO B1305 -1  O  GLU B1304   N  ASP B1297           
SHEET    1 AA8 3 ARG B1356  THR B1357  0                                        
SHEET    2 AA8 3 LEU B1346  CYS B1348 -1  N  LEU B1346   O  THR B1357           
SHEET    3 AA8 3 LEU B1379  PRO B1381 -1  O  GLN B1380   N  ILE B1347           
SHEET    1 AA9 2 PHE B1364  SER B1365  0                                        
SHEET    2 AA9 2 GLY B1368  PRO B1369 -1  O  GLY B1368   N  SER B1365           
SHEET    1 AB1 7 VAL C 170  GLY C 175  0                                        
SHEET    2 AB1 7 CYS C 590  ARG C 597 -1  O  VAL C 593   N  PHE C 174           
SHEET    3 AB1 7 THR C 570  LEU C 576 -1  N  ARG C 573   O  GLN C 594           
SHEET    4 AB1 7 SER C 340  CYS C 346 -1  N  VAL C 344   O  ALA C 572           
SHEET    5 AB1 7 VAL C 374  PHE C 378  1  O  VAL C 374   N  LEU C 343           
SHEET    6 AB1 7 HIS C 419  VAL C 423  1  O  VAL C 421   N  CYS C 375           
SHEET    7 AB1 7 VAL C 453  PHE C 455  1  O  GLN C 454   N  PHE C 422           
SHEET    1 AB2 6 LEU C 193  VAL C 195  0                                        
SHEET    2 AB2 6 CYS C 460  ILE C 464 -1  O  SER C 463   N  LYS C 194           
SHEET    3 AB2 6 VAL C 467  LEU C 471 -1  O  PHE C 469   N  LEU C 462           
SHEET    4 AB2 6 VAL C 537  ILE C 539  1  O  VAL C 537   N  GLY C 470           
SHEET    5 AB2 6 CYS C 554  ASN C 558  1  O  VAL C 557   N  LEU C 538           
SHEET    6 AB2 6 PHE C 547  VAL C 551 -1  N  LYS C 549   O  CYS C 556           
SHEET    1 AB3 6 VAL C 251  CYS C 259  0                                        
SHEET    2 AB3 6 VAL C 270  GLY C 274 -1  O  GLU C 273   N  GLN C 256           
SHEET    3 AB3 6 GLN C 283  ASP C 287 -1  O  ILE C 284   N  LEU C 272           
SHEET    4 AB3 6 LEU C 314  LEU C 319  1  O  LEU C 314   N  ASP C 287           
SHEET    5 AB3 6 VAL C 301  ILE C 307 -1  N  GLU C 305   O  THR C 317           
SHEET    6 AB3 6 VAL C 251  CYS C 259 -1  N  LEU C 253   O  MET C 304           
SHEET    1 AB4 2 SER C 295  LEU C 296  0                                        
SHEET    2 AB4 2 ILE C 485  SER C 486 -1  O  ILE C 485   N  LEU C 296           
SHEET    1 AB5 2 THR C 563  LYS C 564  0                                        
SHEET    2 AB5 2 VAL C 567  GLY C 568 -1  O  VAL C 567   N  LYS C 564           
SHEET    1 AB6 2 PHE D1279  PRO D1282  0                                        
SHEET    2 AB6 2 GLU D1289  TYR D1292 -1  O  TYR D1292   N  PHE D1279           
SHEET    1 AB7 2 PHE D1296  ASP D1297  0                                        
SHEET    2 AB7 2 GLU D1304  PRO D1305 -1  O  GLU D1304   N  ASP D1297           
SHEET    1 AB8 3 ARG D1356  THR D1357  0                                        
SHEET    2 AB8 3 LEU D1346  CYS D1348 -1  N  LEU D1346   O  THR D1357           
SHEET    3 AB8 3 LEU D1379  PRO D1381 -1  O  GLN D1380   N  ILE D1347           
SHEET    1 AB9 2 PHE D1364  SER D1365  0                                        
SHEET    2 AB9 2 GLY D1368  PRO D1369 -1  O  GLY D1368   N  SER D1365           
SHEET    1 AC1 7 VAL E 170  GLY E 175  0                                        
SHEET    2 AC1 7 CYS E 590  ARG E 597 -1  O  VAL E 595   N  VAL E 171           
SHEET    3 AC1 7 THR E 570  LEU E 576 -1  N  ARG E 573   O  GLN E 594           
SHEET    4 AC1 7 SER E 340  CYS E 346 -1  N  SER E 340   O  LEU E 576           
SHEET    5 AC1 7 VAL E 374  PHE E 378  1  O  VAL E 374   N  LEU E 343           
SHEET    6 AC1 7 HIS E 419  VAL E 423  1  O  VAL E 421   N  CYS E 375           
SHEET    7 AC1 7 VAL E 453  PHE E 455  1  O  GLN E 454   N  PHE E 422           
SHEET    1 AC2 6 LEU E 193  LEU E 196  0                                        
SHEET    2 AC2 6 CYS E 460  ILE E 464 -1  O  SER E 463   N  LYS E 194           
SHEET    3 AC2 6 VAL E 467  LEU E 471 -1  O  PHE E 469   N  LEU E 462           
SHEET    4 AC2 6 VAL E 537  ILE E 539  1  O  ILE E 539   N  GLY E 470           
SHEET    5 AC2 6 CYS E 554  ASN E 558  1  O  VAL E 557   N  LEU E 538           
SHEET    6 AC2 6 PHE E 547  VAL E 551 -1  N  LYS E 549   O  CYS E 556           
SHEET    1 AC3 6 VAL E 251  CYS E 259  0                                        
SHEET    2 AC3 6 VAL E 270  GLY E 274 -1  O  GLU E 273   N  GLN E 256           
SHEET    3 AC3 6 GLN E 283  ASP E 287 -1  O  ILE E 284   N  LEU E 272           
SHEET    4 AC3 6 LEU E 314  LEU E 319  1  O  LEU E 314   N  ASP E 287           
SHEET    5 AC3 6 VAL E 301  ILE E 307 -1  N  GLU E 305   O  THR E 317           
SHEET    6 AC3 6 VAL E 251  CYS E 259 -1  N  LEU E 253   O  MET E 304           
SHEET    1 AC4 2 SER E 295  LEU E 296  0                                        
SHEET    2 AC4 2 ILE E 485  SER E 486 -1  O  ILE E 485   N  LEU E 296           
SHEET    1 AC5 2 THR E 563  LYS E 564  0                                        
SHEET    2 AC5 2 VAL E 567  GLY E 568 -1  O  VAL E 567   N  LYS E 564           
SHEET    1 AC6 2 PHE F1279  PRO F1282  0                                        
SHEET    2 AC6 2 GLU F1289  TYR F1292 -1  O  TYR F1292   N  PHE F1279           
SHEET    1 AC7 2 PHE F1296  ASP F1297  0                                        
SHEET    2 AC7 2 GLU F1304  PRO F1305 -1  O  GLU F1304   N  ASP F1297           
SHEET    1 AC8 3 ARG F1356  THR F1357  0                                        
SHEET    2 AC8 3 LEU F1346  CYS F1348 -1  N  LEU F1346   O  THR F1357           
SHEET    3 AC8 3 LEU F1379  PRO F1381 -1  O  GLN F1380   N  ILE F1347           
SHEET    1 AC9 2 PHE F1364  SER F1365  0                                        
SHEET    2 AC9 2 GLY F1368  PRO F1369 -1  O  GLY F1368   N  SER F1365           
SHEET    1 AD1 7 VAL G 170  GLY G 175  0                                        
SHEET    2 AD1 7 CYS G 590  ARG G 597 -1  O  VAL G 593   N  PHE G 174           
SHEET    3 AD1 7 THR G 570  LEU G 576 -1  N  TYR G 575   O  ALA G 592           
SHEET    4 AD1 7 SER G 340  CYS G 346 -1  N  VAL G 344   O  ALA G 572           
SHEET    5 AD1 7 VAL G 374  PHE G 378  1  O  PHE G 378   N  ALA G 345           
SHEET    6 AD1 7 HIS G 419  VAL G 423  1  O  VAL G 421   N  CYS G 375           
SHEET    7 AD1 7 VAL G 453  PHE G 455  1  O  GLN G 454   N  PHE G 422           
SHEET    1 AD2 6 LEU G 193  VAL G 195  0                                        
SHEET    2 AD2 6 CYS G 460  ILE G 464 -1  O  SER G 463   N  LYS G 194           
SHEET    3 AD2 6 VAL G 467  LEU G 471 -1  O  PHE G 469   N  LEU G 462           
SHEET    4 AD2 6 VAL G 537  ILE G 539  1  O  ILE G 539   N  GLY G 470           
SHEET    5 AD2 6 CYS G 554  ASN G 558  1  O  VAL G 557   N  LEU G 538           
SHEET    6 AD2 6 PHE G 547  VAL G 551 -1  N  LYS G 549   O  CYS G 556           
SHEET    1 AD3 6 VAL G 251  CYS G 259  0                                        
SHEET    2 AD3 6 VAL G 270  GLY G 274 -1  O  GLU G 273   N  GLN G 256           
SHEET    3 AD3 6 GLN G 283  ASP G 287 -1  O  ILE G 284   N  LEU G 272           
SHEET    4 AD3 6 LEU G 314  LEU G 319  1  O  LEU G 314   N  ASP G 287           
SHEET    5 AD3 6 VAL G 301  ILE G 307 -1  N  GLU G 305   O  THR G 317           
SHEET    6 AD3 6 VAL G 251  CYS G 259 -1  N  LEU G 253   O  MET G 304           
SHEET    1 AD4 2 SER G 295  LEU G 296  0                                        
SHEET    2 AD4 2 ILE G 485  SER G 486 -1  O  ILE G 485   N  LEU G 296           
SHEET    1 AD5 2 THR G 563  LYS G 564  0                                        
SHEET    2 AD5 2 VAL G 567  GLY G 568 -1  O  VAL G 567   N  LYS G 564           
SHEET    1 AD6 2 PHE H1279  PRO H1282  0                                        
SHEET    2 AD6 2 GLU H1289  TYR H1292 -1  O  TYR H1292   N  PHE H1279           
SHEET    1 AD7 2 PHE H1296  ASP H1297  0                                        
SHEET    2 AD7 2 GLU H1304  PRO H1305 -1  O  GLU H1304   N  ASP H1297           
SHEET    1 AD8 3 ARG H1356  THR H1357  0                                        
SHEET    2 AD8 3 LEU H1346  CYS H1348 -1  N  LEU H1346   O  THR H1357           
SHEET    3 AD8 3 LEU H1379  PRO H1381 -1  O  GLN H1380   N  ILE H1347           
SHEET    1 AD9 2 PHE H1364  SER H1365  0                                        
SHEET    2 AD9 2 GLY H1368  PRO H1369 -1  O  GLY H1368   N  SER H1365           
LINK         SG  CYS B1283                ZN    ZN B1501     1555   1555  2.31  
LINK         SG  CYS B1286                ZN    ZN B1501     1555   1555  2.30  
LINK         SG  CYS B1310                ZN    ZN B1501     1555   1555  2.30  
LINK         SG  CYS B1315                ZN    ZN B1501     1555   1555  2.31  
LINK         SG  CYS B1348                ZN    ZN B1502     1555   1555  2.28  
LINK         SG  CYS B1353                ZN    ZN B1502     1555   1555  2.29  
LINK         SG  CYS B1371                ZN    ZN B1502     1555   1555  2.29  
LINK         SG  CYS B1374                ZN    ZN B1502     1555   1555  2.30  
LINK         SG  CYS D1283                ZN    ZN D1501     1555   1555  2.30  
LINK         SG  CYS D1286                ZN    ZN D1501     1555   1555  2.30  
LINK         SG  CYS D1310                ZN    ZN D1501     1555   1555  2.29  
LINK         SG  CYS D1315                ZN    ZN D1501     1555   1555  2.29  
LINK         SG  CYS D1348                ZN    ZN D1502     1555   1555  2.30  
LINK         SG  CYS D1353                ZN    ZN D1502     1555   1555  2.29  
LINK         SG  CYS D1371                ZN    ZN D1502     1555   1555  2.31  
LINK         SG  CYS D1374                ZN    ZN D1502     1555   1555  2.30  
LINK         SG  CYS F1283                ZN    ZN F1501     1555   1555  2.32  
LINK         SG  CYS F1286                ZN    ZN F1501     1555   1555  2.31  
LINK         SG  CYS F1310                ZN    ZN F1501     1555   1555  2.31  
LINK         SG  CYS F1315                ZN    ZN F1501     1555   1555  2.29  
LINK         SG  CYS F1348                ZN    ZN F1502     1555   1555  2.29  
LINK         SG  CYS F1353                ZN    ZN F1502     1555   1555  2.29  
LINK         SG  CYS F1371                ZN    ZN F1502     1555   1555  2.32  
LINK         SG  CYS F1374                ZN    ZN F1502     1555   1555  2.31  
LINK         SG  CYS H1283                ZN    ZN H1501     1555   1555  2.29  
LINK         SG  CYS H1286                ZN    ZN H1501     1555   1555  2.30  
LINK         SG  CYS H1310                ZN    ZN H1501     1555   1555  2.30  
LINK         SG  CYS H1315                ZN    ZN H1501     1555   1555  2.29  
LINK         SG  CYS H1348                ZN    ZN H1502     1555   1555  2.28  
LINK         SG  CYS H1353                ZN    ZN H1502     1555   1555  2.30  
LINK         SG  CYS H1371                ZN    ZN H1502     1555   1555  2.31  
LINK         SG  CYS H1374                ZN    ZN H1502     1555   1555  2.31  
CISPEP   1 GLY A  347    PRO A  348          0         0.17                     
CISPEP   2 GLY A  379    PRO A  380          0         0.44                     
CISPEP   3 TYR A  435    PRO A  436          0        -0.05                     
CISPEP   4 GLU A  458    PRO A  459          0         0.02                     
CISPEP   5 TYR A  512    PRO A  513          0        -0.45                     
CISPEP   6 GLY C  347    PRO C  348          0         0.35                     
CISPEP   7 GLY C  379    PRO C  380          0         1.22                     
CISPEP   8 TYR C  435    PRO C  436          0        -0.22                     
CISPEP   9 GLU C  458    PRO C  459          0         0.34                     
CISPEP  10 TYR C  512    PRO C  513          0        -0.28                     
CISPEP  11 GLY E  347    PRO E  348          0         0.00                     
CISPEP  12 GLY E  379    PRO E  380          0        -0.44                     
CISPEP  13 TYR E  435    PRO E  436          0        -0.23                     
CISPEP  14 GLU E  458    PRO E  459          0         0.94                     
CISPEP  15 TYR E  512    PRO E  513          0        -0.18                     
CISPEP  16 GLY G  347    PRO G  348          0         0.00                     
CISPEP  17 GLY G  379    PRO G  380          0         0.51                     
CISPEP  18 TYR G  435    PRO G  436          0        -0.26                     
CISPEP  19 GLU G  458    PRO G  459          0         0.76                     
CISPEP  20 TYR G  512    PRO G  513          0        -0.43                     
SITE     1 AC1  4 CYS B1283  CYS B1286  CYS B1310  CYS B1315                    
SITE     1 AC2  4 CYS B1348  CYS B1353  CYS B1371  CYS B1374                    
SITE     1 AC3  4 CYS D1283  CYS D1286  CYS D1310  CYS D1315                    
SITE     1 AC4  4 CYS D1348  CYS D1353  CYS D1371  CYS D1374                    
SITE     1 AC5  4 CYS F1283  CYS F1286  CYS F1310  CYS F1315                    
SITE     1 AC6  4 CYS F1348  CYS F1353  CYS F1371  CYS F1374                    
SITE     1 AC7  4 CYS H1283  CYS H1286  CYS H1310  CYS H1315                    
SITE     1 AC8  4 CYS H1348  CYS H1353  CYS H1371  CYS H1374                    
CRYST1  103.593  137.135  132.092  90.00 100.97  90.00 P 1 21 1      8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.009653  0.000000  0.001871        0.00000                         
SCALE2      0.000000  0.007292  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.007711        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system