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Database: PDB
Entry: 4ZBI
LinkDB: 4ZBI
Original site: 4ZBI 
HEADER    APOPTOSIS/APOPTOSIS INHIBITOR           14-APR-15   4ZBI              
TITLE     MCL-1 COMPLEXED WITH SMALL MOLECULES                                  
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL- 
COMPND   3 1;                                                                   
COMPND   4 CHAIN: A, B, C, D, E, F, G, H, I, J, K, L;                           
COMPND   5 SYNONYM: BCL-2-LIKE PROTEIN 3,BCL2-L-3,BCL-2-RELATED PROTEIN         
COMPND   6 EAT/MCL1,MCL1/EAT;                                                   
COMPND   7 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: MCL1, BCL2L3;                                                  
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    INHIBITOR, COMPLEX, APOPTOSIS-APOPTOSIS INHIBITOR COMPLEX             
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    B.ZHAO                                                                
REVDAT   4   04-DEC-19 4ZBI    1       REMARK                                   
REVDAT   3   27-SEP-17 4ZBI    1       SOURCE KEYWDS JRNL   REMARK              
REVDAT   2   27-MAY-15 4ZBI    1       JRNL                                     
REVDAT   1   29-APR-15 4ZBI    0                                                
JRNL        AUTH   J.P.BURKE,Z.BIAN,S.SHAW,B.ZHAO,C.M.GOODWIN,J.BELMAR,         
JRNL        AUTH 2 C.F.BROWNING,D.VIGIL,A.FRIBERG,D.V.CAMPER,O.W.ROSSANESE,     
JRNL        AUTH 3 T.LEE,E.T.OLEJNICZAK,S.W.FESIK                               
JRNL        TITL   DISCOVERY OF TRICYCLIC INDOLES THAT POTENTLY INHIBIT MCL-1   
JRNL        TITL 2 USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN.     
JRNL        REF    J.MED.CHEM.                   V.  58  3794 2015              
JRNL        REFN                   ISSN 0022-2623                               
JRNL        PMID   25844895                                                     
JRNL        DOI    10.1021/JM501984F                                            
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.50 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX DEV_1951                                      
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.50                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 29.97                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.440                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 90.4                           
REMARK   3   NUMBER OF REFLECTIONS             : 68687                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.183                           
REMARK   3   R VALUE            (WORKING SET) : 0.182                           
REMARK   3   FREE R VALUE                     : 0.240                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 2.890                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 1988                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 30.0000 -  6.0085    0.98     5280   164  0.1285 0.1652        
REMARK   3     2  6.0085 -  4.7754    0.98     5189   158  0.1517 0.2134        
REMARK   3     3  4.7754 -  4.1736    0.98     5185   152  0.1403 0.1854        
REMARK   3     4  4.1736 -  3.7928    0.93     4883   146  0.1538 0.2100        
REMARK   3     5  3.7928 -  3.5214    0.80     4221   133  0.1901 0.2445        
REMARK   3     6  3.5214 -  3.3141    0.94     4997   146  0.2102 0.3022        
REMARK   3     7  3.3141 -  3.1483    0.93     4929   143  0.2201 0.2646        
REMARK   3     8  3.1483 -  3.0114    0.93     4924   150  0.2281 0.2882        
REMARK   3     9  3.0114 -  2.8955    0.91     4742   136  0.2348 0.3062        
REMARK   3    10  2.8955 -  2.7957    0.90     4724   144  0.2287 0.2920        
REMARK   3    11  2.7957 -  2.7083    0.87     4599   136  0.2340 0.3030        
REMARK   3    12  2.7083 -  2.6310    0.86     4508   129  0.2385 0.3240        
REMARK   3    13  2.6310 -  2.5617    0.84     4433   145  0.2596 0.3392        
REMARK   3    14  2.5617 -  2.5000    0.78     4085   106  0.2661 0.3641        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.360            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 25.810           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.010          15116                                  
REMARK   3   ANGLE     :  1.411          20370                                  
REMARK   3   CHIRALITY :  0.066           2208                                  
REMARK   3   PLANARITY :  0.008           2582                                  
REMARK   3   DIHEDRAL  : 18.054           5678                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 71                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -9.8519 -34.1474  -7.8496              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1853 T22:   0.3535                                     
REMARK   3      T33:   0.3285 T12:  -0.0723                                     
REMARK   3      T13:  -0.0247 T23:   0.0399                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3099 L22:   6.2669                                     
REMARK   3      L33:   4.3346 L12:  -2.7008                                     
REMARK   3      L13:  -3.0372 L23:   3.2122                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0190 S12:   0.3370 S13:  -0.9216                       
REMARK   3      S21:  -0.3452 S22:   0.2003 S23:   0.7904                       
REMARK   3      S31:   0.1545 S32:  -0.2970 S33:  -0.0985                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -15.3342 -39.4767 -13.3058              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7402 T22:   1.2918                                     
REMARK   3      T33:   1.2115 T12:   0.1198                                     
REMARK   3      T13:  -0.0695 T23:  -0.1861                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.7629 L22:   1.2595                                     
REMARK   3      L33:   7.6089 L12:   0.3468                                     
REMARK   3      L13:  -3.3310 L23:   1.6174                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6921 S12:  -0.3941 S13:  -0.5296                       
REMARK   3      S21:  -0.3320 S22:   0.4400 S23:  -0.9329                       
REMARK   3      S31:   1.0175 S32:   0.9648 S33:  -0.2732                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 203 THROUGH 280 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -11.2459 -23.2970  -0.7784              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2709 T22:   0.3984                                     
REMARK   3      T33:   0.3998 T12:   0.0226                                     
REMARK   3      T13:   0.0414 T23:   0.0682                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.9483 L22:   1.7471                                     
REMARK   3      L33:   2.2832 L12:   0.3232                                     
REMARK   3      L13:   0.4121 L23:  -0.2248                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0596 S12:   0.0009 S13:   0.1823                       
REMARK   3      S21:   0.0105 S22:   0.1513 S23:   0.4388                       
REMARK   3      S31:  -0.2033 S32:  -0.3230 S33:  -0.0111                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 281 THROUGH 310 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.3095 -30.1080  -3.1651              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2567 T22:   0.3197                                     
REMARK   3      T33:   0.3109 T12:  -0.0285                                     
REMARK   3      T13:   0.0313 T23:   0.0706                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9927 L22:   4.7337                                     
REMARK   3      L33:   3.9763 L12:  -1.4737                                     
REMARK   3      L13:   0.2758 L23:  -2.8459                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0348 S12:  -0.0612 S13:  -0.0103                       
REMARK   3      S21:  -0.2961 S22:   0.0519 S23:  -0.0956                       
REMARK   3      S31:   0.0891 S32:  -0.1511 S33:  -0.0371                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 311 THROUGH 322 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -15.5082 -40.2893   5.5963              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3034 T22:   0.5533                                     
REMARK   3      T33:   0.5356 T12:  -0.0340                                     
REMARK   3      T13:   0.0961 T23:   0.2304                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0176 L22:   0.1146                                     
REMARK   3      L33:   0.8979 L12:   0.0432                                     
REMARK   3      L13:   0.1256 L23:   0.3241                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1232 S12:  -0.7538 S13:  -0.8462                       
REMARK   3      S21:   0.3998 S22:  -0.0336 S23:   0.6218                       
REMARK   3      S31:   0.8256 S32:  -0.6613 S33:   0.2650                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  18.8708  -0.2127   2.4951              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3215 T22:   0.3518                                     
REMARK   3      T33:   0.2283 T12:   0.0150                                     
REMARK   3      T13:  -0.0331 T23:  -0.0175                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1814 L22:   3.3133                                     
REMARK   3      L33:   2.4761 L12:   2.6083                                     
REMARK   3      L13:  -0.1065 L23:  -1.7441                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2059 S12:  -0.0720 S13:   0.3019                       
REMARK   3      S21:  -0.1151 S22:   0.0002 S23:  -0.5488                       
REMARK   3      S31:   0.0376 S32:   0.6482 S33:   0.2163                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  26.9505   3.9076   3.4359              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0506 T22:   1.2248                                     
REMARK   3      T33:   1.0017 T12:   0.0777                                     
REMARK   3      T13:  -0.1691 T23:   0.1201                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1861 L22:   1.1508                                     
REMARK   3      L33:   7.6332 L12:   0.3418                                     
REMARK   3      L13:   1.3368 L23:  -2.5298                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1178 S12:   0.6535 S13:   0.9124                       
REMARK   3      S21:  -0.5747 S22:   0.0477 S23:  -0.1062                       
REMARK   3      S31:  -1.7641 S32:  -0.0214 S33:   0.2800                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 203 THROUGH 255 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  12.0140  -9.6740   8.0270              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3402 T22:   0.3866                                     
REMARK   3      T33:   0.2746 T12:   0.0081                                     
REMARK   3      T13:   0.0472 T23:   0.0329                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9753 L22:   2.1816                                     
REMARK   3      L33:   1.7722 L12:   0.2884                                     
REMARK   3      L13:   0.5184 L23:   0.2926                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1376 S12:  -0.0572 S13:   0.0057                       
REMARK   3      S21:  -0.0826 S22:   0.0410 S23:  -0.0304                       
REMARK   3      S31:   0.0111 S32:   0.1788 S33:  -0.0286                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 256 THROUGH 310 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  11.1007  -5.1590   4.5433              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3183 T22:   0.3580                                     
REMARK   3      T33:   0.2251 T12:  -0.0258                                     
REMARK   3      T13:   0.0077 T23:   0.0050                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7115 L22:   3.8454                                     
REMARK   3      L33:   2.0939 L12:  -1.3986                                     
REMARK   3      L13:   0.1154 L23:  -0.6584                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0681 S12:   0.0403 S13:   0.0013                       
REMARK   3      S21:  -0.0960 S22:  -0.1822 S23:  -0.1035                       
REMARK   3      S31:  -0.0649 S32:   0.0186 S33:  -0.0081                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 311 THROUGH 323 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  11.6946   7.6750  14.4731              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5155 T22:   0.4228                                     
REMARK   3      T33:   0.2502 T12:   0.0165                                     
REMARK   3      T13:  -0.0126 T23:  -0.0160                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3606 L22:   1.7515                                     
REMARK   3      L33:   1.6041 L12:  -0.4043                                     
REMARK   3      L13:  -0.2277 L23:  -1.1351                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4090 S12:  -0.7713 S13:   0.2945                       
REMARK   3      S21:   0.3691 S22:   0.1243 S23:  -0.8321                       
REMARK   3      S31:  -0.0563 S32:   0.6982 S33:  -0.0544                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  19.8044 -37.3363   2.3711              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3085 T22:   0.4146                                     
REMARK   3      T33:   0.2802 T12:  -0.0074                                     
REMARK   3      T13:  -0.0175 T23:   0.1592                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.9828 L22:   4.2554                                     
REMARK   3      L33:   3.0070 L12:  -3.9828                                     
REMARK   3      L13:  -0.4986 L23:  -0.2587                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2587 S12:  -0.5386 S13:   0.2694                       
REMARK   3      S21:   0.4082 S22:  -0.2341 S23:  -0.6433                       
REMARK   3      S31:   0.2279 S32:   0.4798 S33:  -0.0584                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  24.4076 -36.1980  10.7106              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1490 T22:   1.2080                                     
REMARK   3      T33:   1.5368 T12:  -0.0416                                     
REMARK   3      T13:   0.1537 T23:  -0.0281                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.2020 L22:   0.3784                                     
REMARK   3      L33:   3.6180 L12:  -1.1097                                     
REMARK   3      L13:  -3.4019 L23:   1.1765                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4645 S12:  -0.2721 S13:  -0.3610                       
REMARK   3      S21:   0.3639 S22:  -0.9230 S23:   1.0912                       
REMARK   3      S31:   0.2719 S32:  -0.6356 S33:   0.4423                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 203 THROUGH 223 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  26.0305 -47.3343   1.5683              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3862 T22:   0.6494                                     
REMARK   3      T33:   0.4936 T12:   0.0805                                     
REMARK   3      T13:   0.0110 T23:   0.3971                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.9968 L22:   4.2698                                     
REMARK   3      L33:   2.5101 L12:   1.1600                                     
REMARK   3      L13:   0.7310 L23:  -2.6957                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1376 S12:  -0.0345 S13:  -0.1212                       
REMARK   3      S21:   0.0492 S22:  -1.1980 S23:  -0.8458                       
REMARK   3      S31:  -0.1671 S32:   0.9869 S33:  -0.4697                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 224 THROUGH 235 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  28.8874 -41.3307 -17.8668              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6156 T22:   0.9095                                     
REMARK   3      T33:   0.0862 T12:   0.4382                                     
REMARK   3      T13:   0.5350 T23:   0.3816                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4929 L22:   3.7965                                     
REMARK   3      L33:   3.5147 L12:  -2.1016                                     
REMARK   3      L13:   0.5082 L23:   1.1961                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1119 S12:   0.2808 S13:  -0.1774                       
REMARK   3      S21:  -0.1843 S22:  -0.2439 S23:  -0.4436                       
REMARK   3      S31:   0.6586 S32:   0.5572 S33:   0.3917                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 236 THROUGH 254 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  19.0827 -32.4061 -15.6067              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4438 T22:   0.3085                                     
REMARK   3      T33:   0.2010 T12:   0.1169                                     
REMARK   3      T13:   0.0777 T23:   0.2190                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4569 L22:   1.3492                                     
REMARK   3      L33:   1.0795 L12:   1.0268                                     
REMARK   3      L13:   0.5904 L23:   0.1340                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5360 S12:   0.0615 S13:   0.7581                       
REMARK   3      S21:  -0.1564 S22:   0.0732 S23:   0.2787                       
REMARK   3      S31:   0.1479 S32:   0.1674 S33:  -0.0773                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 255 THROUGH 280 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  22.3593 -42.5631  -9.4466              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.2693 T22:  -0.0223                                     
REMARK   3      T33:   0.2933 T12:   0.8622                                     
REMARK   3      T13:  -0.2055 T23:   0.6748                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9028 L22:   2.3348                                     
REMARK   3      L33:   1.5037 L12:   0.3396                                     
REMARK   3      L13:  -0.5102 L23:  -0.2684                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2088 S12:   0.4221 S13:  -0.3388                       
REMARK   3      S21:  -0.4913 S22:  -0.8374 S23:  -0.2804                       
REMARK   3      S31:   0.5694 S32:   0.0312 S33:  -0.1588                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 281 THROUGH 310 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  15.5246 -37.9375  -4.7860              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2671 T22:   0.3900                                     
REMARK   3      T33:   0.2878 T12:   0.0484                                     
REMARK   3      T13:  -0.0157 T23:   0.1036                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1133 L22:   2.5739                                     
REMARK   3      L33:   1.5645 L12:   0.9245                                     
REMARK   3      L13:  -2.2101 L23:  -0.9873                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3204 S12:   0.1745 S13:   0.3262                       
REMARK   3      S21:   0.3135 S22:  -0.2067 S23:   0.3488                       
REMARK   3      S31:  -0.1380 S32:  -0.0296 S33:  -0.0300                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 311 THROUGH 321 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  18.2501 -52.7832   3.2855              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3684 T22:   0.5507                                     
REMARK   3      T33:   0.3852 T12:   0.0519                                     
REMARK   3      T13:   0.0594 T23:   0.2193                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.3142 L22:   2.6376                                     
REMARK   3      L33:   3.7096 L12:  -1.0124                                     
REMARK   3      L13:   0.8028 L23:   2.8118                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3242 S12:  -0.4051 S13:  -0.8171                       
REMARK   3      S21:   0.4250 S22:   0.0465 S23:   0.2333                       
REMARK   3      S31:   0.8413 S32:   0.2027 S33:   0.3025                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  37.0963  -3.2072 -58.1109              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1998 T22:   0.2476                                     
REMARK   3      T33:   0.1678 T12:  -0.0344                                     
REMARK   3      T13:  -0.0380 T23:   0.0447                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3583 L22:   8.1225                                     
REMARK   3      L33:   3.9694 L12:  -2.6953                                     
REMARK   3      L13:  -1.3572 L23:  -0.2400                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0045 S12:  -0.1125 S13:  -0.5693                       
REMARK   3      S21:   0.0774 S22:   0.1868 S23:   0.6984                       
REMARK   3      S31:  -0.0152 S32:  -0.2847 S33:  -0.2914                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  31.9345  -6.7992 -51.8337              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5439 T22:   0.6124                                     
REMARK   3      T33:   0.4925 T12:  -0.0089                                     
REMARK   3      T13:   0.1099 T23:   0.1358                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2798 L22:   3.9088                                     
REMARK   3      L33:   6.8044 L12:  -2.3909                                     
REMARK   3      L13:  -3.8866 L23:   4.5910                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5794 S12:  -0.3409 S13:  -0.2928                       
REMARK   3      S21:   0.3628 S22:  -0.1309 S23:   0.5883                       
REMARK   3      S31:   0.0102 S32:  -1.2149 S33:   0.0497                       
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 203 THROUGH 255 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  36.7962   6.8415 -66.2751              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3259 T22:   0.3391                                     
REMARK   3      T33:   0.2263 T12:   0.0359                                     
REMARK   3      T13:  -0.0237 T23:   0.0501                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.1814 L22:   1.0773                                     
REMARK   3      L33:   2.4973 L12:  -0.2556                                     
REMARK   3      L13:   0.0394 L23:  -0.6310                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1208 S12:   0.1222 S13:   0.0675                       
REMARK   3      S21:  -0.1835 S22:  -0.0029 S23:   0.1166                       
REMARK   3      S31:  -0.1424 S32:  -0.2108 S33:   0.0104                       
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 256 THROUGH 301 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  38.0144   3.2080 -65.9733              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3289 T22:   0.2602                                     
REMARK   3      T33:   0.2593 T12:   0.0302                                     
REMARK   3      T13:   0.0226 T23:   0.0690                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2640 L22:   1.3304                                     
REMARK   3      L33:   2.8858 L12:  -0.0926                                     
REMARK   3      L13:   0.9391 L23:   0.2813                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0373 S12:   0.2246 S13:  -0.0637                       
REMARK   3      S21:  -0.1350 S22:   0.0402 S23:   0.0937                       
REMARK   3      S31:  -0.0753 S32:  -0.0430 S33:   0.0145                       
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 302 THROUGH 322 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  46.9115   5.9543 -50.6086              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3509 T22:   0.3823                                     
REMARK   3      T33:   0.2291 T12:   0.0085                                     
REMARK   3      T13:  -0.0127 T23:   0.0485                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0526 L22:   2.6313                                     
REMARK   3      L33:   1.6447 L12:  -0.6474                                     
REMARK   3      L13:   0.2301 L23:   0.1657                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2797 S12:  -0.6481 S13:   0.0289                       
REMARK   3      S21:   0.4013 S22:   0.2999 S23:   0.0966                       
REMARK   3      S31:  -0.3099 S32:   0.3598 S33:  -0.0402                       
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  33.6282 -17.6712 -28.0815              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2731 T22:   0.3876                                     
REMARK   3      T33:   0.1772 T12:   0.0388                                     
REMARK   3      T13:   0.0052 T23:   0.1350                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.3538 L22:   6.8044                                     
REMARK   3      L33:   1.2634 L12:  -0.5006                                     
REMARK   3      L13:  -0.2502 L23:   0.3221                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4303 S12:   0.0995 S13:  -0.0885                       
REMARK   3      S21:   0.5526 S22:  -0.4585 S23:  -0.5012                       
REMARK   3      S31:   0.0583 S32:   0.4767 S33:  -0.1215                       
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  41.1848 -22.7561 -26.8259              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0905 T22:   0.9201                                     
REMARK   3      T33:   0.8798 T12:   0.1263                                     
REMARK   3      T13:  -0.1640 T23:  -0.0353                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8705 L22:   0.3758                                     
REMARK   3      L33:   0.8701 L12:   0.8349                                     
REMARK   3      L13:  -1.2733 L23:  -0.5709                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.9095 S12:   0.7572 S13:  -0.2241                       
REMARK   3      S21:  -2.0699 S22:  -0.7551 S23:   0.4701                       
REMARK   3      S31:  -0.3586 S32:  -0.1751 S33:   0.6725                       
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 203 THROUGH 254 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  28.9270  -5.8564 -25.7876              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4479 T22:   0.4288                                     
REMARK   3      T33:   0.2862 T12:   0.0381                                     
REMARK   3      T13:   0.0185 T23:   0.0943                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8637 L22:   0.9745                                     
REMARK   3      L33:   2.2117 L12:  -0.4765                                     
REMARK   3      L13:  -0.8971 L23:   0.3653                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0646 S12:  -0.0658 S13:   0.1084                       
REMARK   3      S21:   0.5192 S22:  -0.0088 S23:   0.0106                       
REMARK   3      S31:  -0.3405 S32:   0.2404 S33:  -0.0128                       
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 255 THROUGH 310 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  27.4606 -10.4263 -29.2722              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3449 T22:   0.3431                                     
REMARK   3      T33:   0.2021 T12:   0.0440                                     
REMARK   3      T13:   0.0448 T23:   0.0649                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.4419 L22:   2.0429                                     
REMARK   3      L33:   3.5553 L12:   0.1260                                     
REMARK   3      L13:  -0.1131 L23:  -0.1582                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0072 S12:  -0.0646 S13:   0.0314                       
REMARK   3      S21:   0.3523 S22:  -0.0746 S23:   0.2240                       
REMARK   3      S31:  -0.2293 S32:  -0.0431 S33:   0.0097                       
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 311 THROUGH 322 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  39.6260 -11.0576 -41.5269              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3093 T22:   0.4244                                     
REMARK   3      T33:   0.1923 T12:   0.0381                                     
REMARK   3      T13:   0.0349 T23:   0.0604                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4707 L22:   0.3014                                     
REMARK   3      L33:   1.6887 L12:   0.3536                                     
REMARK   3      L13:  -2.4802 L23:  -0.1244                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1233 S12:   0.3918 S13:  -0.0959                       
REMARK   3      S21:  -0.3087 S22:  -0.1303 S23:  -0.3549                       
REMARK   3      S31:   0.1812 S32:   0.8655 S33:   0.0809                       
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.6909   3.4976 -16.8201              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2717 T22:   0.3727                                     
REMARK   3      T33:   0.2420 T12:   0.0293                                     
REMARK   3      T13:   0.0284 T23:  -0.0463                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.6387 L22:   4.4863                                     
REMARK   3      L33:   5.0307 L12:  -2.4464                                     
REMARK   3      L13:   0.5876 L23:  -3.2385                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1351 S12:   0.2290 S13:  -0.4184                       
REMARK   3      S21:  -0.1207 S22:   0.0693 S23:   0.2234                       
REMARK   3      S31:   0.3603 S32:  -0.9668 S33:  -0.1837                       
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -14.7034   4.6303 -15.0531              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8081 T22:   1.3663                                     
REMARK   3      T33:   1.0492 T12:   0.0305                                     
REMARK   3      T13:  -0.0171 T23:   0.0321                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.4101 L22:   0.5412                                     
REMARK   3      L33:   5.0187 L12:  -0.1756                                     
REMARK   3      L13:  -1.0366 L23:  -1.2966                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3770 S12:  -1.2705 S13:   0.2167                       
REMARK   3      S21:   0.3295 S22:  -0.0822 S23:  -0.0282                       
REMARK   3      S31:   0.5879 S32:  -0.6528 S33:   0.1027                       
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 203 THROUGH 254 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   1.7153   3.0190 -27.6137              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3977 T22:   0.4861                                     
REMARK   3      T33:   0.3707 T12:   0.0246                                     
REMARK   3      T13:   0.0833 T23:  -0.0600                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1214 L22:   1.1344                                     
REMARK   3      L33:   1.2718 L12:  -0.2240                                     
REMARK   3      L13:   0.4195 L23:   0.0354                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1974 S12:   0.5182 S13:  -0.4585                       
REMARK   3      S21:  -0.5204 S22:  -0.0117 S23:  -0.0589                       
REMARK   3      S31:  -0.1484 S32:  -0.3000 S33:   0.0128                       
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 255 THROUGH 280 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   3.0302   5.2918 -26.4831              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3118 T22:   0.4283                                     
REMARK   3      T33:   0.2672 T12:  -0.0090                                     
REMARK   3      T13:   0.0593 T23:  -0.0940                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5680 L22:   3.1464                                     
REMARK   3      L33:   2.3913 L12:   0.7539                                     
REMARK   3      L13:   0.4513 L23:   0.7224                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2373 S12:   0.6060 S13:  -0.4424                       
REMARK   3      S21:  -0.6116 S22:   0.2946 S23:  -0.3853                       
REMARK   3      S31:  -0.2901 S32:  -0.0427 S33:  -0.0634                       
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 281 THROUGH 301 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   0.4290  -3.3900 -20.3335              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3319 T22:   0.4027                                     
REMARK   3      T33:   0.3942 T12:  -0.0297                                     
REMARK   3      T13:   0.0558 T23:  -0.1020                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3089 L22:   3.7176                                     
REMARK   3      L33:   4.3127 L12:   1.4867                                     
REMARK   3      L13:   1.0935 L23:   2.6340                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0979 S12:   0.3657 S13:  -0.8625                       
REMARK   3      S21:   0.5379 S22:   0.0095 S23:  -0.3261                       
REMARK   3      S31:   0.8505 S32:  -0.1547 S33:  -0.0332                       
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 302 THROUGH 321 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   1.8265  16.3852 -14.7279              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4961 T22:   0.3004                                     
REMARK   3      T33:   0.3072 T12:   0.1014                                     
REMARK   3      T13:  -0.0268 T23:   0.0222                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.6341 L22:   1.4481                                     
REMARK   3      L33:   4.9218 L12:   1.5295                                     
REMARK   3      L13:   0.1270 L23:  -0.1904                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0656 S12:  -0.2190 S13:   0.3514                       
REMARK   3      S21:   0.1858 S22:   0.1096 S23:  -0.2647                       
REMARK   3      S31:  -0.5872 S32:  -0.5814 S33:   0.0496                       
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  34.0169 -56.5636 -34.0230              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3928 T22:   0.3213                                     
REMARK   3      T33:   0.1547 T12:  -0.0145                                     
REMARK   3      T13:   0.0470 T23:  -0.0200                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.8127 L22:   6.4655                                     
REMARK   3      L33:   4.6544 L12:  -2.9851                                     
REMARK   3      L13:   1.3471 L23:  -1.7634                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4018 S12:  -0.9982 S13:  -0.5589                       
REMARK   3      S21:   0.2465 S22:   0.0106 S23:   0.4462                       
REMARK   3      S31:  -0.0486 S32:  -0.6056 S33:  -0.1781                       
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  29.3841 -57.4669 -26.1365              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6981 T22:   1.2908                                     
REMARK   3      T33:   0.7206 T12:   0.0488                                     
REMARK   3      T13:   0.1815 T23:   0.4557                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0007 L22:   3.2409                                     
REMARK   3      L33:   8.8638 L12:  -0.5241                                     
REMARK   3      L13:   5.4995 L23:   4.1456                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.1460 S12:  -0.8033 S13:   0.6648                       
REMARK   3      S21:   0.5182 S22:  -1.1883 S23:  -0.5712                       
REMARK   3      S31:  -0.7149 S32:   0.6205 S33:  -0.2065                       
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 203 THROUGH 235 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  28.4344 -48.2029 -42.9451              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5180 T22:   0.4764                                     
REMARK   3      T33:   0.2913 T12:   0.1460                                     
REMARK   3      T13:   0.0991 T23:  -0.0265                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6996 L22:   3.0701                                     
REMARK   3      L33:   2.8020 L12:   0.3208                                     
REMARK   3      L13:   0.7348 L23:   1.2767                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2840 S12:  -0.1529 S13:   0.3667                       
REMARK   3      S21:  -0.1913 S22:   0.0633 S23:   0.1712                       
REMARK   3      S31:  -0.8201 S32:  -1.0944 S33:   0.1233                       
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 236 THROUGH 283 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  33.1787 -56.6853 -48.4253              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3768 T22:   0.2909                                     
REMARK   3      T33:   0.2662 T12:  -0.0017                                     
REMARK   3      T13:   0.0048 T23:  -0.0549                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9936 L22:   0.9548                                     
REMARK   3      L33:   2.6812 L12:  -0.9808                                     
REMARK   3      L13:   0.2050 L23:  -0.5759                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1831 S12:   0.0870 S13:  -0.3057                       
REMARK   3      S21:  -0.6053 S22:   0.0969 S23:   0.1627                       
REMARK   3      S31:  -0.0840 S32:  -0.2092 S33:   0.0268                       
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 284 THROUGH 308 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  40.3730 -56.8622 -40.6792              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3574 T22:   0.2712                                     
REMARK   3      T33:   0.2326 T12:  -0.0220                                     
REMARK   3      T13:   0.0094 T23:   0.0058                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.9398 L22:   4.3784                                     
REMARK   3      L33:   2.2839 L12:   3.6200                                     
REMARK   3      L13:   1.2029 L23:   1.1220                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3610 S12:   0.2661 S13:  -0.3365                       
REMARK   3      S21:   0.4378 S22:  -0.0924 S23:  -0.1306                       
REMARK   3      S31:   0.1177 S32:   0.1589 S33:  -0.0093                       
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 309 THROUGH 322 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  39.0122 -41.2705 -32.7488              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9681 T22:  -0.2072                                     
REMARK   3      T33:  -0.1742 T12:  -0.0650                                     
REMARK   3      T13:   0.0656 T23:  -0.6853                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3554 L22:   5.3165                                     
REMARK   3      L33:   1.1518 L12:  -2.0470                                     
REMARK   3      L13:  -0.9342 L23:   0.3305                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0853 S12:  -0.7088 S13:   0.8391                       
REMARK   3      S21:   1.1939 S22:   0.0421 S23:  -0.4511                       
REMARK   3      S31:  -0.9427 S32:  -0.2450 S33:   0.0546                       
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   5.9708 -24.8817 -39.5012              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2155 T22:   0.3386                                     
REMARK   3      T33:   0.2898 T12:   0.1135                                     
REMARK   3      T13:   0.0784 T23:   0.0282                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3375 L22:   8.6135                                     
REMARK   3      L33:   2.7009 L12:   2.6609                                     
REMARK   3      L13:   1.0890 L23:  -1.9622                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4496 S12:  -0.0693 S13:   0.5129                       
REMARK   3      S21:   0.3277 S22:  -0.1161 S23:   0.9401                       
REMARK   3      S31:   0.1284 S32:  -0.4587 S33:  -0.1857                       
REMARK   3   TLS GROUP : 42                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   1.3057 -20.7677 -45.9413              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5381 T22:   0.8227                                     
REMARK   3      T33:   0.6530 T12:   0.0587                                     
REMARK   3      T13:   0.0002 T23:   0.1829                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9400 L22:   2.2105                                     
REMARK   3      L33:   4.6370 L12:  -1.4370                                     
REMARK   3      L13:  -1.0344 L23:   1.4092                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.3620 S12:  -0.4631 S13:  -1.1909                       
REMARK   3      S21:  -0.5484 S22:   0.1147 S23:   0.5121                       
REMARK   3      S31:   0.6079 S32:  -0.6213 S33:  -0.4619                       
REMARK   3   TLS GROUP : 43                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 203 THROUGH 223 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   3.6952 -35.3786 -44.7313              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4300 T22:   0.3058                                     
REMARK   3      T33:   0.4676 T12:  -0.0669                                     
REMARK   3      T13:  -0.0109 T23:   0.0516                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.3808 L22:   4.0357                                     
REMARK   3      L33:   8.1178 L12:   1.0034                                     
REMARK   3      L13:  -1.2436 L23:  -3.8693                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1946 S12:   0.0730 S13:  -0.6073                       
REMARK   3      S21:  -0.9631 S22:  -0.0867 S23:   0.0761                       
REMARK   3      S31:   1.2194 S32:  -0.7926 S33:  -0.1754                       
REMARK   3   TLS GROUP : 44                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 224 THROUGH 254 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   7.8313 -35.2508 -23.6664              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4385 T22:   0.3805                                     
REMARK   3      T33:   0.2199 T12:   0.0607                                     
REMARK   3      T13:   0.1456 T23:   0.1210                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.9370 L22:   2.2187                                     
REMARK   3      L33:   2.5694 L12:   0.2572                                     
REMARK   3      L13:  -0.0726 L23:   0.0064                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2063 S12:  -0.4672 S13:  -0.0729                       
REMARK   3      S21:   0.3380 S22:   0.2002 S23:   0.1897                       
REMARK   3      S31:   0.4017 S32:  -0.2073 S33:   0.0267                       
REMARK   3   TLS GROUP : 45                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 255 THROUGH 301 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   7.5121 -31.6754 -31.8033              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3357 T22:   0.3942                                     
REMARK   3      T33:   0.2664 T12:   0.0586                                     
REMARK   3      T13:   0.0357 T23:   0.1201                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.5727 L22:   2.2080                                     
REMARK   3      L33:   2.7902 L12:   0.3857                                     
REMARK   3      L13:  -1.0454 L23:   0.5913                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0252 S12:  -0.3015 S13:  -0.1274                       
REMARK   3      S21:   0.2564 S22:   0.1141 S23:   0.1405                       
REMARK   3      S31:   0.2469 S32:  -0.2045 S33:   0.0235                       
REMARK   3   TLS GROUP : 46                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 302 THROUGH 321 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  16.7459 -33.1465 -46.5618              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4180 T22:   0.3161                                     
REMARK   3      T33:   0.2682 T12:   0.0851                                     
REMARK   3      T13:   0.0212 T23:  -0.0182                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.0800 L22:   2.1078                                     
REMARK   3      L33:   1.6101 L12:   0.7235                                     
REMARK   3      L13:   0.2005 L23:  -0.6726                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2966 S12:   0.2145 S13:  -0.3432                       
REMARK   3      S21:  -0.7460 S22:   0.2877 S23:  -0.0038                       
REMARK   3      S31:   0.4013 S32:   0.1028 S33:  -0.0461                       
REMARK   3   TLS GROUP : 47                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   2.9317  -9.3019 -69.2960              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3053 T22:   0.4539                                     
REMARK   3      T33:   0.2412 T12:   0.0100                                     
REMARK   3      T13:   0.0246 T23:   0.0643                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.8514 L22:   8.5235                                     
REMARK   3      L33:   0.7775 L12:  -3.0786                                     
REMARK   3      L13:   1.3590 L23:  -0.6742                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2886 S12:   0.1705 S13:   0.0770                       
REMARK   3      S21:  -1.0117 S22:  -0.2359 S23:  -0.5380                       
REMARK   3      S31:  -0.2712 S32:   0.5247 S33:  -0.0564                       
REMARK   3   TLS GROUP : 48                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  10.5655  -4.4649 -70.3431              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0663 T22:   0.9406                                     
REMARK   3      T33:   0.9888 T12:  -0.1590                                     
REMARK   3      T13:   0.1448 T23:   0.0208                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.8994 L22:   1.3592                                     
REMARK   3      L33:   2.2999 L12:   1.1643                                     
REMARK   3      L13:   2.3629 L23:   1.7173                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.2663 S12:  -0.7987 S13:   1.4184                       
REMARK   3      S21:   1.6535 S22:   1.2773 S23:  -0.2711                       
REMARK   3      S31:   1.0356 S32:   2.0676 S33:  -0.6928                       
REMARK   3   TLS GROUP : 49                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 203 THROUGH 254 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -1.2315 -21.2979 -71.8620              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4518 T22:   0.4787                                     
REMARK   3      T33:   0.3145 T12:   0.0709                                     
REMARK   3      T13:   0.0311 T23:   0.0644                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.4154 L22:   1.1867                                     
REMARK   3      L33:   1.9983 L12:   0.8355                                     
REMARK   3      L13:   0.3499 L23:   0.4079                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0092 S12:   0.2433 S13:  -0.1441                       
REMARK   3      S21:  -0.2698 S22:  -0.0400 S23:  -0.1069                       
REMARK   3      S31:   0.2862 S32:   0.3477 S33:  -0.0256                       
REMARK   3   TLS GROUP : 50                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 255 THROUGH 301 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -2.7792 -17.6825 -71.7240              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4338 T22:   0.3920                                     
REMARK   3      T33:   0.2200 T12:   0.0825                                     
REMARK   3      T13:  -0.0211 T23:   0.0244                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3984 L22:   1.3078                                     
REMARK   3      L33:   2.3273 L12:  -0.0470                                     
REMARK   3      L13:   0.6842 L23:   0.2327                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0928 S12:   0.3557 S13:  -0.0727                       
REMARK   3      S21:  -0.4196 S22:  -0.0478 S23:  -0.0438                       
REMARK   3      S31:  -0.1359 S32:  -0.1965 S33:  -0.0130                       
REMARK   3   TLS GROUP : 51                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 302 THROUGH 310 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.3123 -12.9386 -53.9969              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2958 T22:   0.3695                                     
REMARK   3      T33:   0.2674 T12:  -0.0133                                     
REMARK   3      T13:  -0.0694 T23:   0.0563                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.0045 L22:   2.0851                                     
REMARK   3      L33:   3.6785 L12:   1.2607                                     
REMARK   3      L13:  -3.2031 L23:   0.9315                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0929 S12:  -0.2874 S13:  -0.2308                       
REMARK   3      S21:   0.4694 S22:   0.0907 S23:  -0.0356                       
REMARK   3      S31:   0.1636 S32:   0.7196 S33:  -0.0375                       
REMARK   3   TLS GROUP : 52                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 311 THROUGH 321 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   7.7613 -15.8875 -56.2455              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2939 T22:   0.3336                                     
REMARK   3      T33:   0.3791 T12:   0.0490                                     
REMARK   3      T13:  -0.0342 T23:   0.0335                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6309 L22:   0.3217                                     
REMARK   3      L33:   0.8628 L12:   0.3524                                     
REMARK   3      L13:  -0.1710 L23:  -0.2916                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1419 S12:   0.1359 S13:   0.2435                       
REMARK   3      S21:   0.1669 S22:  -0.1228 S23:  -0.1710                       
REMARK   3      S31:  -0.1547 S32:   0.0504 S33:   0.0339                       
REMARK   3   TLS GROUP : 53                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   0.6418 -64.7817 -41.7677              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2652 T22:   0.5039                                     
REMARK   3      T33:   0.2391 T12:  -0.1326                                     
REMARK   3      T13:   0.0212 T23:   0.0065                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.6775 L22:   5.6808                                     
REMARK   3      L33:   5.3381 L12:  -0.7656                                     
REMARK   3      L13:   2.4579 L23:  -3.0613                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0353 S12:   0.0585 S13:   0.1744                       
REMARK   3      S21:  -1.0162 S22:   0.0618 S23:  -1.0143                       
REMARK   3      S31:  -0.0832 S32:   0.8849 S33:   0.1286                       
REMARK   3   TLS GROUP : 54                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   8.4748 -61.8666 -46.3190              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1760 T22:   1.0436                                     
REMARK   3      T33:   1.2514 T12:  -0.1030                                     
REMARK   3      T13:   0.4299 T23:  -0.1698                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.7716 L22:   0.0518                                     
REMARK   3      L33:   2.0584 L12:   0.4403                                     
REMARK   3      L13:   2.7903 L23:   0.3253                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.4026 S12:  -1.2293 S13:   0.8719                       
REMARK   3      S21:   1.4285 S22:   0.6200 S23:  -0.3064                       
REMARK   3      S31:  -1.2601 S32:  -0.4388 S33:  -0.5269                       
REMARK   3   TLS GROUP : 55                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 203 THROUGH 223 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   8.9050 -68.0325 -33.6644              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2511 T22:   1.0618                                     
REMARK   3      T33:   0.4170 T12:  -0.0957                                     
REMARK   3      T13:   0.0314 T23:   0.0630                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.9111 L22:   1.1937                                     
REMARK   3      L33:   2.7067 L12:  -0.0771                                     
REMARK   3      L13:   0.1088 L23:   1.7921                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0107 S12:   0.1250 S13:  -0.2323                       
REMARK   3      S21:  -0.1707 S22:   0.3826 S23:  -1.1311                       
REMARK   3      S31:  -0.0703 S32:   0.8527 S33:   0.1711                       
REMARK   3   TLS GROUP : 56                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 224 THROUGH 239 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.0833 -85.1507 -35.5096              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4067 T22:   0.4678                                     
REMARK   3      T33:   0.3660 T12:   0.0108                                     
REMARK   3      T13:   0.0354 T23:   0.0713                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.3043 L22:   1.8387                                     
REMARK   3      L33:   9.2748 L12:   0.2177                                     
REMARK   3      L13:   5.1970 L23:   0.4826                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1267 S12:  -0.2614 S13:  -0.8882                       
REMARK   3      S21:  -0.0529 S22:  -0.2242 S23:  -0.6425                       
REMARK   3      S31:   0.9980 S32:  -0.2201 S33:  -0.2594                       
REMARK   3   TLS GROUP : 57                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 240 THROUGH 280 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -6.0040 -75.2321 -35.0883              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2778 T22:   0.4760                                     
REMARK   3      T33:   0.1804 T12:  -0.0195                                     
REMARK   3      T13:  -0.0526 T23:   0.0125                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5190 L22:   1.6643                                     
REMARK   3      L33:   0.3177 L12:   0.7613                                     
REMARK   3      L13:   0.1874 L23:   0.3620                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0173 S12:   0.0877 S13:  -0.1439                       
REMARK   3      S21:  -0.1094 S22:  -0.0105 S23:  -0.0500                       
REMARK   3      S31:   0.1150 S32:   0.3288 S33:   0.0079                       
REMARK   3   TLS GROUP : 58                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 281 THROUGH 301 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.9934 -71.8771 -42.9051              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3906 T22:   0.5227                                     
REMARK   3      T33:   0.3099 T12:  -0.0167                                     
REMARK   3      T13:   0.0098 T23:  -0.0298                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2100 L22:   3.2869                                     
REMARK   3      L33:   3.4867 L12:   0.7379                                     
REMARK   3      L13:   0.5461 L23:   0.9931                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1247 S12:   0.3668 S13:  -0.3478                       
REMARK   3      S21:  -1.1176 S22:  -0.0940 S23:   0.1978                       
REMARK   3      S31:  -0.3481 S32:   0.0376 S33:   0.0074                       
REMARK   3   TLS GROUP : 59                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 302 THROUGH 310 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -6.0889 -58.2990 -27.2486              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1636 T22:   0.2720                                     
REMARK   3      T33:   0.1631 T12:  -0.4297                                     
REMARK   3      T13:  -0.1768 T23:  -0.1239                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.4026 L22:   2.9378                                     
REMARK   3      L33:   2.7283 L12:  -0.7819                                     
REMARK   3      L13:   1.9805 L23:   1.0838                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2091 S12:   0.0503 S13:   0.0600                       
REMARK   3      S21:   0.7105 S22:   0.1350 S23:  -0.5392                       
REMARK   3      S31:  -0.1398 S32:   0.4387 S33:   0.0930                       
REMARK   3   TLS GROUP : 60                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 311 THROUGH 322 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   6.7603 -60.4300 -27.6646              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0714 T22:   0.7769                                     
REMARK   3      T33:   0.2687 T12:  -0.2741                                     
REMARK   3      T13:  -0.3916 T23:   0.0966                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2274 L22:   1.3658                                     
REMARK   3      L33:   1.2006 L12:  -0.5481                                     
REMARK   3      L13:  -0.4967 L23:   1.2382                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1368 S12:   0.2072 S13:   0.4132                       
REMARK   3      S21:   0.3610 S22:  -0.0904 S23:  -1.1397                       
REMARK   3      S31:  -0.6927 S32:   0.4991 S33:   0.4903                       
REMARK   3   TLS GROUP : 61                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  32.7640 -28.5418  35.0930              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4920 T22:   0.3887                                     
REMARK   3      T33:   0.4174 T12:   0.1254                                     
REMARK   3      T13:   0.0913 T23:   0.0599                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.2629 L22:   4.3585                                     
REMARK   3      L33:   6.0585 L12:  -1.4822                                     
REMARK   3      L13:  -1.6864 L23:  -3.1481                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3524 S12:  -0.4037 S13:  -0.6453                       
REMARK   3      S21:  -0.0816 S22:  -0.2944 S23:  -0.9116                       
REMARK   3      S31:   0.6780 S32:   1.1419 S33:   0.3179                       
REMARK   3   TLS GROUP : 62                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  40.5713 -32.4961  35.9383              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0437 T22:   1.4226                                     
REMARK   3      T33:   1.2751 T12:   0.2690                                     
REMARK   3      T13:   0.0207 T23:   0.2329                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9408 L22:   0.9514                                     
REMARK   3      L33:   3.0875 L12:  -1.1522                                     
REMARK   3      L13:   1.6192 L23:  -0.5825                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1405 S12:  -0.3449 S13:  -0.1432                       
REMARK   3      S21:   0.4931 S22:  -0.5421 S23:   0.1199                       
REMARK   3      S31:   0.6323 S32:  -0.4313 S33:   0.5614                       
REMARK   3   TLS GROUP : 63                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 203 THROUGH 235 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  30.7472 -23.4503  22.7547              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5174 T22:   0.5509                                     
REMARK   3      T33:   0.3886 T12:   0.0720                                     
REMARK   3      T13:   0.0983 T23:   0.0180                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0821 L22:   7.3303                                     
REMARK   3      L33:   0.8115 L12:  -1.3889                                     
REMARK   3      L13:  -0.9798 L23:   0.3514                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3206 S12:   0.4610 S13:  -0.4310                       
REMARK   3      S21:  -0.3599 S22:  -0.2402 S23:  -0.2051                       
REMARK   3      S31:   0.4670 S32:   0.0751 S33:   0.1288                       
REMARK   3   TLS GROUP : 64                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 236 THROUGH 310 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  24.4765 -20.9567  31.9676              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4136 T22:   0.3934                                     
REMARK   3      T33:   0.2524 T12:  -0.0010                                     
REMARK   3      T13:  -0.0001 T23:   0.0110                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0821 L22:   2.3396                                     
REMARK   3      L33:   2.4529 L12:  -0.1205                                     
REMARK   3      L13:  -0.8400 L23:  -0.6776                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1695 S12:  -0.1052 S13:   0.0626                       
REMARK   3      S21:   0.0409 S22:  -0.0419 S23:   0.0504                       
REMARK   3      S31:   0.4004 S32:   0.0378 S33:   0.0052                       
REMARK   3   TLS GROUP : 65                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 311 THROUGH 320 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  27.4932 -38.2405  24.6370              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2005 T22:   0.3901                                     
REMARK   3      T33:   0.6279 T12:   0.0511                                     
REMARK   3      T13:   0.3570 T23:   0.0069                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.3945 L22:   4.6155                                     
REMARK   3      L33:   7.0913 L12:   2.3263                                     
REMARK   3      L13:   3.4161 L23:  -2.2876                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4105 S12:   0.1437 S13:  -1.1881                       
REMARK   3      S21:  -0.8944 S22:   0.0310 S23:  -0.1565                       
REMARK   3      S31:   0.6108 S32:   0.3348 S33:   0.0760                       
REMARK   3   TLS GROUP : 66                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 171 THROUGH 191 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  28.0440 -32.7675 -83.0403              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4795 T22:   0.2553                                     
REMARK   3      T33:   0.3627 T12:  -0.0283                                     
REMARK   3      T13:  -0.0551 T23:   0.0203                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.4710 L22:   4.2000                                     
REMARK   3      L33:   7.8734 L12:   0.6296                                     
REMARK   3      L13:   1.4135 L23:  -4.0124                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2041 S12:   0.0678 S13:  -0.1110                       
REMARK   3      S21:  -0.2340 S22:   0.0921 S23:   0.6996                       
REMARK   3      S31:   0.1895 S32:  -0.8794 S33:  -0.1328                       
REMARK   3   TLS GROUP : 67                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 192 THROUGH 202 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  19.2819 -34.1980 -84.9777              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9474 T22:   1.2117                                     
REMARK   3      T33:   1.1030 T12:   0.0714                                     
REMARK   3      T13:  -0.0940 T23:  -0.0713                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.5968 L22:   2.5399                                     
REMARK   3      L33:   3.5172 L12:  -2.2155                                     
REMARK   3      L13:  -3.7335 L23:   0.9295                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.7770 S12:   1.1283 S13:  -1.1475                       
REMARK   3      S21:  -0.6090 S22:   0.1247 S23:  -0.2037                       
REMARK   3      S31:   2.3586 S32:  -0.1297 S33:   0.4493                       
REMARK   3   TLS GROUP : 68                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 203 THROUGH 223 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  26.3766 -41.7218 -75.1648              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6212 T22:   0.4158                                     
REMARK   3      T33:   0.3591 T12:  -0.0749                                     
REMARK   3      T13:   0.1233 T23:  -0.0044                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8048 L22:   4.3748                                     
REMARK   3      L33:   4.6294 L12:   0.0667                                     
REMARK   3      L13:  -1.6946 L23:   2.9419                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1576 S12:  -0.0740 S13:  -0.1050                       
REMARK   3      S21:   0.5105 S22:  -0.2288 S23:   0.6130                       
REMARK   3      S31:   0.1175 S32:  -0.9201 S33:   0.0403                       
REMARK   3   TLS GROUP : 69                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 224 THROUGH 254 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  39.0595 -25.2555 -69.0511              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6121 T22:   0.4032                                     
REMARK   3      T33:   0.3066 T12:   0.0121                                     
REMARK   3      T13:  -0.0430 T23:  -0.0190                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9033 L22:   2.0671                                     
REMARK   3      L33:   2.1282 L12:   0.0418                                     
REMARK   3      L13:  -0.8249 L23:  -0.6600                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1147 S12:  -0.5146 S13:   0.3028                       
REMARK   3      S21:   0.1607 S22:   0.1268 S23:   0.1617                       
REMARK   3      S31:   0.1060 S32:  -0.2859 S33:  -0.0181                       
REMARK   3   TLS GROUP : 70                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 255 THROUGH 310 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  35.9455 -32.4564 -77.3402              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5071 T22:   0.2657                                     
REMARK   3      T33:   0.3110 T12:   0.0026                                     
REMARK   3      T13:   0.0294 T23:   0.0460                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2768 L22:   2.7502                                     
REMARK   3      L33:   2.8473 L12:   0.9506                                     
REMARK   3      L13:  -0.7942 L23:   0.2360                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0574 S12:   0.0401 S13:  -0.0417                       
REMARK   3      S21:  -0.1131 S22:  -0.0952 S23:  -0.0551                       
REMARK   3      S31:   0.0023 S32:  -0.1359 S33:   0.0396                       
REMARK   3   TLS GROUP : 71                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 311 THROUGH 321 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  31.6039 -47.6427 -80.8905              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8801 T22:   0.0401                                     
REMARK   3      T33:   0.4508 T12:   0.0442                                     
REMARK   3      T13:   0.2281 T23:  -0.1817                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.2325 L22:   4.0671                                     
REMARK   3      L33:   5.3982 L12:  -0.8237                                     
REMARK   3      L13:  -0.0516 L23:  -0.3836                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3186 S12:   0.3376 S13:  -0.3450                       
REMARK   3      S21:  -0.2101 S22:  -0.0527 S23:   0.4579                       
REMARK   3      S31:   0.6505 S32:  -0.4701 S33:  -0.0223                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 4ZBI COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 15-APR-15.                  
REMARK 100 THE DEPOSITION ID IS D_1000208987.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 11-JUL-12                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 6.0-8.0                            
REMARK 200  NUMBER OF CRYSTALS USED        : NULL                               
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 21-ID-D                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.07816                            
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 300 MM CCD               
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 68726                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.500                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 90.7                               
REMARK 200  DATA REDUNDANCY                : 2.700                              
REMARK 200  R MERGE                    (I) : 0.06000                            
REMARK 200  R SYM                      (I) : 0.04900                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 17.3000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.50                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.54                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 82.4                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.00                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.33000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.300                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL                         
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 52.87                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.61                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: PEG3350, MAGNESIUM CHLORIDE, BIS-TRIS,   
REMARK 280  EVAPORATION                                                         
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y+1/2,-Z                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       67.00750            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12                   
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 4                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 5                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 6                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 7                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 8                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: H                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 9                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: I                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 10                                                      
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: J                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 11                                                      
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: K                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 12                                                      
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: L                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ASP A   323                                                      
REMARK 465     LEU A   324                                                      
REMARK 465     GLU A   325                                                      
REMARK 465     GLY A   326                                                      
REMARK 465     GLY A   327                                                      
REMARK 465     LEU B   324                                                      
REMARK 465     GLU B   325                                                      
REMARK 465     GLY B   326                                                      
REMARK 465     GLY B   327                                                      
REMARK 465     GLU C   322                                                      
REMARK 465     ASP C   323                                                      
REMARK 465     LEU C   324                                                      
REMARK 465     GLU C   325                                                      
REMARK 465     GLY C   326                                                      
REMARK 465     GLY C   327                                                      
REMARK 465     ASP D   323                                                      
REMARK 465     LEU D   324                                                      
REMARK 465     GLU D   325                                                      
REMARK 465     GLY D   326                                                      
REMARK 465     GLY D   327                                                      
REMARK 465     ASP E   323                                                      
REMARK 465     LEU E   324                                                      
REMARK 465     GLU E   325                                                      
REMARK 465     GLY E   326                                                      
REMARK 465     GLY E   327                                                      
REMARK 465     GLU F   322                                                      
REMARK 465     ASP F   323                                                      
REMARK 465     LEU F   324                                                      
REMARK 465     GLU F   325                                                      
REMARK 465     GLY F   326                                                      
REMARK 465     GLY F   327                                                      
REMARK 465     ASP G   323                                                      
REMARK 465     LEU G   324                                                      
REMARK 465     GLU G   325                                                      
REMARK 465     GLY G   326                                                      
REMARK 465     GLY G   327                                                      
REMARK 465     GLU H   322                                                      
REMARK 465     ASP H   323                                                      
REMARK 465     LEU H   324                                                      
REMARK 465     GLU H   325                                                      
REMARK 465     GLY H   326                                                      
REMARK 465     GLY H   327                                                      
REMARK 465     GLU I   322                                                      
REMARK 465     ASP I   323                                                      
REMARK 465     LEU I   324                                                      
REMARK 465     GLU I   325                                                      
REMARK 465     GLY I   326                                                      
REMARK 465     GLY I   327                                                      
REMARK 465     ASP J   323                                                      
REMARK 465     LEU J   324                                                      
REMARK 465     GLU J   325                                                      
REMARK 465     GLY J   326                                                      
REMARK 465     GLY J   327                                                      
REMARK 465     VAL K   321                                                      
REMARK 465     GLU K   322                                                      
REMARK 465     ASP K   323                                                      
REMARK 465     LEU K   324                                                      
REMARK 465     GLU K   325                                                      
REMARK 465     GLY K   326                                                      
REMARK 465     GLY K   327                                                      
REMARK 465     GLU L   322                                                      
REMARK 465     ASP L   323                                                      
REMARK 465     LEU L   324                                                      
REMARK 465     GLU L   325                                                      
REMARK 465     GLY L   326                                                      
REMARK 465     GLY L   327                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     VAL A 321    CG1  CG2                                            
REMARK 470     GLU A 322    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 194    CG   CD   CE   NZ                                   
REMARK 470     LYS B 197    CG   CD   CE   NZ                                   
REMARK 470     ASP B 323    CG   OD1  OD2                                       
REMARK 470     LYS C 194    CG   CD   CE   NZ                                   
REMARK 470     LYS C 197    CG   CD   CE   NZ                                   
REMARK 470     ARG C 201    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E 194    CG   CD   CE   NZ                                   
REMARK 470     THR E 196    OG1  CG2                                            
REMARK 470     LYS F 194    CG   CD   CE   NZ                                   
REMARK 470     LYS F 197    CG   CD   CE   NZ                                   
REMARK 470     VAL F 321    CG1  CG2                                            
REMARK 470     LYS G 194    CG   CD   CE   NZ                                   
REMARK 470     PRO G 198    CG   CD                                             
REMARK 470     GLU G 322    CG   CD   OE1  OE2                                  
REMARK 470     LYS H 194    CG   CD   CE   NZ                                   
REMARK 470     LYS I 194    CG   CD   CE   NZ                                   
REMARK 470     THR I 196    OG1  CG2                                            
REMARK 470     LYS J 194    CG   CD   CE   NZ                                   
REMARK 470     THR J 196    OG1  CG2                                            
REMARK 470     LYS J 197    CG   CD   CE   NZ                                   
REMARK 470     PRO J 198    CG   CD                                             
REMARK 470     ARG J 201    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU J 322    CG   CD   OE1  OE2                                  
REMARK 470     LYS K 194    CG   CD   CE   NZ                                   
REMARK 470     LYS K 197    CG   CD   CE   NZ                                   
REMARK 470     PRO K 198    CG   CD                                             
REMARK 470     LYS L 194    CG   CD   CE   NZ                                   
REMARK 470     LYS L 197    CG   CD   CE   NZ                                   
REMARK 470     PRO L 198    CG   CD                                             
REMARK 470     ARG L 201    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   N    ASP D   172     O    HOH D   501              2.03            
REMARK 500   NH1  ARG B   187     O    HOH B   501              2.06            
REMARK 500   NH2  ARG E   248     O    LEU F   235              2.11            
REMARK 500   O    LEU C   235     NH2  ARG H   248              2.15            
REMARK 500   OG   SER A   183     OE2  GLU A   288              2.15            
REMARK 500   O    ASP D   256     NH1  ARG D   263              2.16            
REMARK 500   O    ASP B   256     NH1  ARG B   263              2.18            
REMARK 500   OE2  GLU H   211     NH2  ARG H   215              2.18            
REMARK 500   OE1  GLU B   288     O    HOH B   501              2.18            
REMARK 500   OE1  GLU G   173     OG   SER G   202              2.19            
REMARK 500   OG   SER J   285     O    HOH J   501              2.19            
REMARK 500   OD2  ASP D   172     O    HOH D   502              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ARG D 303   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.3 DEGREES          
REMARK 500    LEU E 213   CB  -  CG  -  CD2 ANGL. DEV. = -10.9 DEGREES          
REMARK 500    PRO G 198   N   -  CA  -  CB  ANGL. DEV. =   7.3 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASP A 172     -131.66     49.35                                   
REMARK 500    ASP A 236       56.90     36.70                                   
REMARK 500    ASP B 172     -127.62     51.43                                   
REMARK 500    ASP B 236       56.62     38.33                                   
REMARK 500    VAL B 321       15.24     99.18                                   
REMARK 500    ASP C 236       56.05     37.84                                   
REMARK 500    HIS C 320      -78.70    -60.69                                   
REMARK 500    ASP D 172      -99.22   -118.06                                   
REMARK 500    ASP D 236       58.04     39.93                                   
REMARK 500    ASP E 172     -121.65     48.57                                   
REMARK 500    ASP E 236       55.39     36.30                                   
REMARK 500    ASP F 172     -131.54     46.61                                   
REMARK 500    ASP G 172      -95.31   -103.23                                   
REMARK 500    ASP G 236       57.13     39.54                                   
REMARK 500    ASP H 172       72.69     49.33                                   
REMARK 500    ASP H 236       55.21     39.81                                   
REMARK 500    ASP I 172     -127.15     45.95                                   
REMARK 500    ASP I 236       61.06     35.60                                   
REMARK 500    LYS J 197      150.50    -42.17                                   
REMARK 500    ASP J 236       54.60     36.35                                   
REMARK 500    ASP K 172       75.01     54.64                                   
REMARK 500    ASP K 236       56.04     38.68                                   
REMARK 500    GLU K 317        2.11    -67.33                                   
REMARK 500    PHE K 319       60.97   -106.95                                   
REMARK 500    ASP L 172       70.26     52.69                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 A 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 B 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 C 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 D 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 E 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 F 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 G 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 H 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 I 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 J 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 K 400                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 4M6 L 400                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 4ZBF   RELATED DB: PDB                                   
REMARK 900 SAME PROTEIN                                                         
DBREF  4ZBI A  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI B  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI C  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI D  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI E  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI F  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI G  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI H  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI I  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI J  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI K  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
DBREF  4ZBI L  172   327  UNP    Q07820   MCL1_HUMAN     172    327             
SEQADV 4ZBI GLY A  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY B  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY C  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY D  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY E  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY F  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY G  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY H  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY I  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY J  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY K  171  UNP  Q07820              EXPRESSION TAG                 
SEQADV 4ZBI GLY L  171  UNP  Q07820              EXPRESSION TAG                 
SEQRES   1 A  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 A  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 A  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 A  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 A  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 A  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 A  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 A  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 A  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 A  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 A  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 A  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 A  157  GLY                                                          
SEQRES   1 B  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 B  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 B  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 B  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 B  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 B  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 B  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 B  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 B  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 B  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 B  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 B  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 B  157  GLY                                                          
SEQRES   1 C  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 C  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 C  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 C  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 C  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 C  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 C  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 C  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 C  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 C  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 C  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 C  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 C  157  GLY                                                          
SEQRES   1 D  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 D  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 D  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 D  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 D  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 D  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 D  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 D  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 D  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 D  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 D  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 D  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 D  157  GLY                                                          
SEQRES   1 E  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 E  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 E  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 E  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 E  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 E  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 E  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 E  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 E  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 E  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 E  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 E  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 E  157  GLY                                                          
SEQRES   1 F  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 F  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 F  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 F  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 F  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 F  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 F  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 F  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 F  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 F  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 F  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 F  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 F  157  GLY                                                          
SEQRES   1 G  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 G  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 G  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 G  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 G  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 G  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 G  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 G  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 G  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 G  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 G  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 G  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 G  157  GLY                                                          
SEQRES   1 H  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 H  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 H  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 H  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 H  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 H  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 H  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 H  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 H  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 H  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 H  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 H  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 H  157  GLY                                                          
SEQRES   1 I  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 I  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 I  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 I  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 I  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 I  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 I  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 I  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 I  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 I  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 I  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 I  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 I  157  GLY                                                          
SEQRES   1 J  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 J  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 J  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 J  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 J  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 J  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 J  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 J  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 J  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 J  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 J  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 J  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 J  157  GLY                                                          
SEQRES   1 K  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 K  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 K  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 K  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 K  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 K  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 K  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 K  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 K  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 K  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 K  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 K  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 K  157  GLY                                                          
SEQRES   1 L  157  GLY ASP GLU LEU TYR ARG GLN SER LEU GLU ILE ILE SER          
SEQRES   2 L  157  ARG TYR LEU ARG GLU GLN ALA THR GLY ALA LYS ASP THR          
SEQRES   3 L  157  LYS PRO MET GLY ARG SER GLY ALA THR SER ARG LYS ALA          
SEQRES   4 L  157  LEU GLU THR LEU ARG ARG VAL GLY ASP GLY VAL GLN ARG          
SEQRES   5 L  157  ASN HIS GLU THR ALA PHE GLN GLY MET LEU ARG LYS LEU          
SEQRES   6 L  157  ASP ILE LYS ASN GLU ASP ASP VAL LYS SER LEU SER ARG          
SEQRES   7 L  157  VAL MET ILE HIS VAL PHE SER ASP GLY VAL THR ASN TRP          
SEQRES   8 L  157  GLY ARG ILE VAL THR LEU ILE SER PHE GLY ALA PHE VAL          
SEQRES   9 L  157  ALA LYS HIS LEU LYS THR ILE ASN GLN GLU SER CYS ILE          
SEQRES  10 L  157  GLU PRO LEU ALA GLU SER ILE THR ASP VAL LEU VAL ARG          
SEQRES  11 L  157  THR LYS ARG ASP TRP LEU VAL LYS GLN ARG GLY TRP ASP          
SEQRES  12 L  157  GLY PHE VAL GLU PHE PHE HIS VAL GLU ASP LEU GLU GLY          
SEQRES  13 L  157  GLY                                                          
HET    4M6  A 400      29                                                       
HET    4M6  B 400      29                                                       
HET    4M6  C 400      29                                                       
HET    4M6  D 400      29                                                       
HET    4M6  E 400      29                                                       
HET    4M6  F 400      29                                                       
HET    4M6  G 400      29                                                       
HET    4M6  H 400      29                                                       
HET    4M6  I 400      29                                                       
HET    4M6  J 400      29                                                       
HET    4M6  K 400      29                                                       
HET    4M6  L 400      29                                                       
HETNAM     4M6 1-[3-(NAPHTHALEN-1-YLOXY)PROPYL]-5,6-DIHYDRO-4H-                 
HETNAM   2 4M6  PYRROLO[3,2,1-IJ]QUINOLINE-2-CARBOXYLIC ACID                    
FORMUL  13  4M6    12(C25 H23 N O3)                                             
FORMUL  25  HOH   *177(H2 O)                                                    
HELIX    1 AA1 GLY A  171  GLY A  192  1                                  22    
HELIX    2 AA2 SER A  202  HIS A  224  1                                  23    
HELIX    3 AA3 HIS A  224  ASP A  236  1                                  13    
HELIX    4 AA4 ASN A  239  SER A  245  1                                   7    
HELIX    5 AA5 LEU A  246  SER A  255  1                                  10    
HELIX    6 AA6 ASN A  260  ILE A  281  1                                  22    
HELIX    7 AA7 GLN A  283  SER A  285  5                                   3    
HELIX    8 AA8 CYS A  286  GLN A  309  1                                  24    
HELIX    9 AA9 ARG A  310  PHE A  319  1                                  10    
HELIX   10 AB1 ASP B  172  GLY B  192  1                                  21    
HELIX   11 AB2 SER B  202  HIS B  224  1                                  23    
HELIX   12 AB3 HIS B  224  ASP B  236  1                                  13    
HELIX   13 AB4 ASN B  239  SER B  245  1                                   7    
HELIX   14 AB5 LEU B  246  ASP B  256  1                                  11    
HELIX   15 AB6 ASN B  260  ILE B  281  1                                  22    
HELIX   16 AB7 GLN B  283  SER B  285  5                                   3    
HELIX   17 AB8 CYS B  286  GLN B  309  1                                  24    
HELIX   18 AB9 ARG B  310  PHE B  319  1                                  10    
HELIX   19 AC1 ASP C  172  GLY C  192  1                                  21    
HELIX   20 AC2 SER C  202  HIS C  224  1                                  23    
HELIX   21 AC3 HIS C  224  ASP C  236  1                                  13    
HELIX   22 AC4 ASN C  239  SER C  245  1                                   7    
HELIX   23 AC5 LEU C  246  SER C  255  1                                  10    
HELIX   24 AC6 ASN C  260  ILE C  281  1                                  22    
HELIX   25 AC7 GLN C  283  SER C  285  5                                   3    
HELIX   26 AC8 CYS C  286  GLN C  309  1                                  24    
HELIX   27 AC9 ARG C  310  PHE C  319  1                                  10    
HELIX   28 AD1 ASP D  172  GLY D  192  1                                  21    
HELIX   29 AD2 SER D  202  HIS D  224  1                                  23    
HELIX   30 AD3 HIS D  224  ASP D  236  1                                  13    
HELIX   31 AD4 ASN D  239  SER D  245  1                                   7    
HELIX   32 AD5 LEU D  246  SER D  255  1                                  10    
HELIX   33 AD6 ASN D  260  ILE D  281  1                                  22    
HELIX   34 AD7 GLN D  283  SER D  285  5                                   3    
HELIX   35 AD8 CYS D  286  LYS D  302  1                                  17    
HELIX   36 AD9 LYS D  302  GLN D  309  1                                   8    
HELIX   37 AE1 ARG D  310  PHE D  319  1                                  10    
HELIX   38 AE2 ASP E  172  GLY E  192  1                                  21    
HELIX   39 AE3 SER E  202  HIS E  224  1                                  23    
HELIX   40 AE4 HIS E  224  ASP E  236  1                                  13    
HELIX   41 AE5 ASN E  239  SER E  245  1                                   7    
HELIX   42 AE6 LEU E  246  ASP E  256  1                                  11    
HELIX   43 AE7 ASN E  260  ILE E  281  1                                  22    
HELIX   44 AE8 GLN E  283  SER E  285  5                                   3    
HELIX   45 AE9 CYS E  286  LYS E  302  1                                  17    
HELIX   46 AF1 LYS E  302  GLN E  309  1                                   8    
HELIX   47 AF2 ARG E  310  PHE E  319  1                                  10    
HELIX   48 AF3 ASP F  172  GLY F  192  1                                  21    
HELIX   49 AF4 SER F  202  HIS F  224  1                                  23    
HELIX   50 AF5 HIS F  224  ASP F  236  1                                  13    
HELIX   51 AF6 ASN F  239  SER F  245  1                                   7    
HELIX   52 AF7 LEU F  246  SER F  255  1                                  10    
HELIX   53 AF8 ASN F  260  ILE F  281  1                                  22    
HELIX   54 AF9 GLN F  283  SER F  285  5                                   3    
HELIX   55 AG1 CYS F  286  GLN F  309  1                                  24    
HELIX   56 AG2 ARG F  310  PHE F  319  1                                  10    
HELIX   57 AG3 ASP G  172  GLY G  192  1                                  21    
HELIX   58 AG4 SER G  202  HIS G  224  1                                  23    
HELIX   59 AG5 HIS G  224  ASP G  236  1                                  13    
HELIX   60 AG6 ASN G  239  SER G  245  1                                   7    
HELIX   61 AG7 LEU G  246  SER G  255  1                                  10    
HELIX   62 AG8 ASN G  260  ILE G  281  1                                  22    
HELIX   63 AG9 GLN G  283  SER G  285  5                                   3    
HELIX   64 AH1 CYS G  286  GLN G  309  1                                  24    
HELIX   65 AH2 ARG G  310  PHE G  319  1                                  10    
HELIX   66 AH3 ASP H  172  GLY H  192  1                                  21    
HELIX   67 AH4 SER H  202  HIS H  224  1                                  23    
HELIX   68 AH5 HIS H  224  ASP H  236  1                                  13    
HELIX   69 AH6 ASN H  239  SER H  245  1                                   7    
HELIX   70 AH7 LEU H  246  SER H  255  1                                  10    
HELIX   71 AH8 ASN H  260  THR H  280  1                                  21    
HELIX   72 AH9 ILE H  281  ASN H  282  5                                   2    
HELIX   73 AI1 GLN H  283  SER H  285  5                                   3    
HELIX   74 AI2 CYS H  286  LYS H  302  1                                  17    
HELIX   75 AI3 LYS H  302  GLN H  309  1                                   8    
HELIX   76 AI4 ARG H  310  PHE H  319  1                                  10    
HELIX   77 AI5 ASP I  172  GLY I  192  1                                  21    
HELIX   78 AI6 SER I  202  HIS I  224  1                                  23    
HELIX   79 AI7 HIS I  224  ASP I  236  1                                  13    
HELIX   80 AI8 ASN I  239  SER I  245  1                                   7    
HELIX   81 AI9 LEU I  246  ASP I  256  1                                  11    
HELIX   82 AJ1 ASN I  260  ILE I  281  1                                  22    
HELIX   83 AJ2 GLN I  283  SER I  285  5                                   3    
HELIX   84 AJ3 CYS I  286  LYS I  302  1                                  17    
HELIX   85 AJ4 LYS I  302  GLN I  309  1                                   8    
HELIX   86 AJ5 ARG I  310  PHE I  319  1                                  10    
HELIX   87 AJ6 ASP J  172  GLY J  192  1                                  21    
HELIX   88 AJ7 SER J  202  HIS J  224  1                                  23    
HELIX   89 AJ8 HIS J  224  ASP J  236  1                                  13    
HELIX   90 AJ9 ASN J  239  SER J  245  1                                   7    
HELIX   91 AK1 LEU J  246  SER J  255  1                                  10    
HELIX   92 AK2 ASN J  260  ILE J  281  1                                  22    
HELIX   93 AK3 GLN J  283  SER J  285  5                                   3    
HELIX   94 AK4 CYS J  286  LYS J  302  1                                  17    
HELIX   95 AK5 LYS J  302  GLN J  309  1                                   8    
HELIX   96 AK6 ARG J  310  PHE J  319  1                                  10    
HELIX   97 AK7 ASP K  172  GLY K  192  1                                  21    
HELIX   98 AK8 SER K  202  HIS K  224  1                                  23    
HELIX   99 AK9 HIS K  224  ASP K  236  1                                  13    
HELIX  100 AL1 ASN K  239  SER K  245  1                                   7    
HELIX  101 AL2 LEU K  246  SER K  255  1                                  10    
HELIX  102 AL3 ASN K  260  ILE K  281  1                                  22    
HELIX  103 AL4 GLN K  283  SER K  285  5                                   3    
HELIX  104 AL5 CYS K  286  GLN K  309  1                                  24    
HELIX  105 AL6 ARG K  310  GLU K  317  1                                   8    
HELIX  106 AL7 ASP L  172  GLY L  192  1                                  21    
HELIX  107 AL8 SER L  202  HIS L  224  1                                  23    
HELIX  108 AL9 HIS L  224  LEU L  235  1                                  12    
HELIX  109 AM1 ASN L  239  SER L  245  1                                   7    
HELIX  110 AM2 LEU L  246  SER L  255  1                                  10    
HELIX  111 AM3 ASN L  260  ILE L  281  1                                  22    
HELIX  112 AM4 GLN L  283  SER L  285  5                                   3    
HELIX  113 AM5 CYS L  286  GLN L  309  1                                  24    
HELIX  114 AM6 ARG L  310  PHE L  319  1                                  10    
CISPEP   1 ASP J  256    GLY J  257          0         0.41                     
SITE     1 AC1  8 MET A 250  VAL A 253  ARG A 263  THR A 266                    
SITE     2 AC1  8 LEU A 267  PHE A 270  GLY A 271  ILE A 294                    
SITE     1 AC2  6 MET B 231  LEU B 235  VAL B 253  ARG B 263                    
SITE     2 AC2  6 LEU B 267  PHE B 270                                          
SITE     1 AC3  7 MET C 250  VAL C 253  PHE C 254  ARG C 263                    
SITE     2 AC3  7 THR C 266  LEU C 267  PHE C 270                               
SITE     1 AC4  9 PHE D 228  MET D 231  LEU D 235  MET D 250                    
SITE     2 AC4  9 VAL D 253  ARG D 263  THR D 266  LEU D 267                    
SITE     3 AC4  9 PHE D 270                                                     
SITE     1 AC5  7 PHE E 228  MET E 250  VAL E 253  PHE E 254                    
SITE     2 AC5  7 ARG E 263  THR E 266  PHE E 270                               
SITE     1 AC6  9 MET F 231  MET F 250  VAL F 253  PHE F 254                    
SITE     2 AC6  9 ARG F 263  THR F 266  LEU F 267  PHE F 270                    
SITE     3 AC6  9 GLY F 271                                                     
SITE     1 AC7 10 PHE G 228  VAL G 249  MET G 250  VAL G 253                    
SITE     2 AC7 10 PHE G 254  ARG G 263  THR G 266  LEU G 267                    
SITE     3 AC7 10 PHE G 270  ILE G 294                                          
SITE     1 AC8  7 MET H 231  LEU H 235  VAL H 253  PHE H 254                    
SITE     2 AC8  7 ARG H 263  LEU H 267  PHE H 270                               
SITE     1 AC9 10 PHE I 228  MET I 231  LEU I 235  VAL I 253                    
SITE     2 AC9 10 ARG I 263  THR I 266  LEU I 267  PHE I 270                    
SITE     3 AC9 10 GLY I 271  ILE I 294                                          
SITE     1 AD1  8 LEU J 235  MET J 250  VAL J 253  PHE J 254                    
SITE     2 AD1  8 ARG J 263  THR J 266  LEU J 267  PHE J 270                    
SITE     1 AD2  7 LEU K 235  MET K 250  VAL K 253  ARG K 263                    
SITE     2 AD2  7 LEU K 267  PHE K 270  GLY K 271                               
SITE     1 AD3  8 VAL L 249  MET L 250  VAL L 253  ARG L 263                    
SITE     2 AD3  8 THR L 266  LEU L 267  PHE L 270  GLY L 271                    
CRYST1   62.256  134.015  135.931  90.00  99.65  90.00 P 1 21 1     24          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.016063  0.000000  0.002731        0.00000                         
SCALE2      0.000000  0.007462  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.007462        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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