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Database: PDB
Entry: 5A0Q
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Original site: 5A0Q 
HEADER    HYDROLASE                               22-APR-15   5A0Q              
TITLE     CRYO-EM REVEALS THE CONFORMATION OF A SUBSTRATE ANALOGUE IN THE HUMAN 
TITLE    2 20S PROTEASOME CORE                                                  
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-6;                           
COMPND   3 CHAIN: A, O;                                                         
COMPND   4 SYNONYM: 27 KDA PROSOMAL PROTEIN, P27K, MACROPAIN IOTA CHAIN,        
COMPND   5 MULTICATALYTIC ENDOPEPTIDASE COMPLEX IOTA CHAIN, PROTEASOME IOTA     
COMPND   6 CHAIN;                                                               
COMPND   7 EC: 3.4.25.1;                                                        
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-2;                           
COMPND  10 CHAIN: B, P;                                                         
COMPND  11 SYNONYM: MACROPAIN SUBUNIT C3, MULTICATALYTIC ENDOPEPTIDASE COMPLEX  
COMPND  12 SUBUNIT C3, PROTEASOME COMPONENT C3;                                 
COMPND  13 EC: 3.4.25.1;                                                        
COMPND  14 MOL_ID: 3;                                                           
COMPND  15 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-4;                           
COMPND  16 CHAIN: C, Q;                                                         
COMPND  17 SYNONYM: MACROPAIN SUBUNIT C9, MULTICATALYTIC ENDOPEPTIDASE COMPLEX  
COMPND  18 SUBUNIT C9, PROTEASOME COMPONENT C9, PROTEASOME SUBUNIT L;           
COMPND  19 EC: 3.4.25.1;                                                        
COMPND  20 MOL_ID: 4;                                                           
COMPND  21 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-7;                           
COMPND  22 CHAIN: D, R;                                                         
COMPND  23 SYNONYM: PROTEASOME SUBUNIT RC6-1, PROTEASOME SUBUNIT XAPC7;         
COMPND  24 EC: 3.4.25.1;                                                        
COMPND  25 MOL_ID: 5;                                                           
COMPND  26 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-5;                           
COMPND  27 CHAIN: E, S;                                                         
COMPND  28 SYNONYM: MACROPAIN ZETA CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX  
COMPND  29 ZETA CHAIN, PROTEASOME ZETA CHAIN;                                   
COMPND  30 EC: 3.4.25.1;                                                        
COMPND  31 MOL_ID: 6;                                                           
COMPND  32 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-1;                           
COMPND  33 CHAIN: F, T;                                                         
COMPND  34 SYNONYM: 30 KDA PROSOMAL PROTEIN, PROS-30, MACROPAIN SUBUNIT C2,     
COMPND  35 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C2, PROTEASOME COMPONENT
COMPND  36 C2, PROTEASOME NU CHAIN;                                             
COMPND  37 EC: 3.4.25.1;                                                        
COMPND  38 MOL_ID: 7;                                                           
COMPND  39 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-3;                           
COMPND  40 CHAIN: G, U;                                                         
COMPND  41 SYNONYM: MACROPAIN SUBUNIT C8, MULTICATALYTIC ENDOPEPTIDASE COMPLEX  
COMPND  42 SUBUNIT C8, PROTEASOME COMPONENT C8;                                 
COMPND  43 EC: 3.4.25.1;                                                        
COMPND  44 MOL_ID: 8;                                                           
COMPND  45 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-6;                            
COMPND  46 CHAIN: H, V;                                                         
COMPND  47 SYNONYM: MACROPAIN DELTA CHAIN, MULTICATALYTIC ENDOPEPTIDASE COMPLEX 
COMPND  48 DELTA CHAIN, PROTEASOME DELTA CHAIN, PROTEASOME SUBUNIT Y;           
COMPND  49 EC: 3.4.25.1;                                                        
COMPND  50 OTHER_DETAILS: SUBUNIT PARTIALLY BOUND TO THE INHIBITOR ADAMANTANE-  
COMPND  51 ACETYL-(6-AMINOHEXANOYL)3-(LEUCINYL)3-VINYL-(METHYL)-SULFONE         
COMPND  52 (ADAAHX3L3VS);                                                       
COMPND  53 MOL_ID: 9;                                                           
COMPND  54 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-7;                            
COMPND  55 CHAIN: I, W;                                                         
COMPND  56 SYNONYM: MACROPAIN CHAIN Z, MULTICATALYTIC ENDOPEPTIDASE COMPLEX     
COMPND  57 CHAIN Z, PROTEASOME SUBUNIT Z;                                       
COMPND  58 EC: 3.4.25.1;                                                        
COMPND  59 OTHER_DETAILS: SUBUNIT PARTIALLY BOUND TO THE INHIBITOR ADAMANTANE-  
COMPND  60 ACETYL-(6-AMINOHEXANOYL)3-(LEUCINYL)3-VINYL-(METHYL)-SULFONE         
COMPND  61 (ADAAHX3L3VS);                                                       
COMPND  62 MOL_ID: 10;                                                          
COMPND  63 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-3;                            
COMPND  64 CHAIN: J, X;                                                         
COMPND  65 SYNONYM: PROTEASOME CHAIN 13, PROTEASOME COMPONENT C10-II, PROTEASOME
COMPND  66 THETA CHAIN;                                                         
COMPND  67 EC: 3.4.25.1;                                                        
COMPND  68 MOL_ID: 11;                                                          
COMPND  69 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-2;                            
COMPND  70 CHAIN: K, Y;                                                         
COMPND  71 SYNONYM: MACROPAIN SUBUNIT C7-I, MULTICATALYTIC ENDOPEPTIDASE COMPLEX
COMPND  72 SUBUNIT C7-I, PROTEASOME COMPONENT C7-I;                             
COMPND  73 EC: 3.4.25.1;                                                        
COMPND  74 MOL_ID: 12;                                                          
COMPND  75 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-5;                            
COMPND  76 CHAIN: L, Z;                                                         
COMPND  77 SYNONYM: MACROPAIN EPSILON CHAIN, MULTICATALYTIC ENDOPEPTIDASE       
COMPND  78 COMPLEX EPSILON CHAIN, PROTEASOME CHAIN 6, PROTEASOME EPSILON CHAIN, 
COMPND  79 PROTEASOME SUBUNIT MB1, PROTEASOME SUBUNIT X;                        
COMPND  80 EC: 3.4.25.1;                                                        
COMPND  81 OTHER_DETAILS: SUBUNIT BOUND TO THE INHIBITOR ADAMANTANE-ACETYL-(6-  
COMPND  82 AMINOHEXANOYL)3-(LEUCINYL)3-VINYL-(METHYL)-SULFONE (ADAAHX3L3VS);    
COMPND  83 MOL_ID: 13;                                                          
COMPND  84 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-1;                            
COMPND  85 CHAIN: M, a;                                                         
COMPND  86 SYNONYM: MACROPAIN SUBUNIT C5, MULTICATALYTIC ENDOPEPTIDASE COMPLEX  
COMPND  87 SUBUNIT C5, PROTEASOME COMPONENT C5, PROTEASOME GAMMA CHAIN;         
COMPND  88 EC: 3.4.25.1;                                                        
COMPND  89 MOL_ID: 14;                                                          
COMPND  90 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-4;                            
COMPND  91 CHAIN: N, b;                                                         
COMPND  92 SYNONYM: 26 KDA PROSOMAL PROTEIN, PROS-26, MACROPAIN BETA CHAIN,     
COMPND  93 MULTICATALYTIC ENDOPEPTIDASE COMPLEX BETA CHAIN, PROTEASOME BETA     
COMPND  94 CHAIN, PROTEASOME CHAIN 3, HSN3;                                     
COMPND  95 EC: 3.4.25.1                                                         
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 CELL: ERYTHROCYTES;                                                  
SOURCE   6 MOL_ID: 2;                                                           
SOURCE   7 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   8 ORGANISM_COMMON: HUMAN;                                              
SOURCE   9 ORGANISM_TAXID: 9606;                                                
SOURCE  10 CELL: ERYTHROCYTES;                                                  
SOURCE  11 MOL_ID: 3;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  13 ORGANISM_COMMON: HUMAN;                                              
SOURCE  14 ORGANISM_TAXID: 9606;                                                
SOURCE  15 CELL: ERYTHROCYTES;                                                  
SOURCE  16 MOL_ID: 4;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  18 ORGANISM_COMMON: HUMAN;                                              
SOURCE  19 ORGANISM_TAXID: 9606;                                                
SOURCE  20 CELL: ERYTHROCYTES;                                                  
SOURCE  21 MOL_ID: 5;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  23 ORGANISM_COMMON: HUMAN;                                              
SOURCE  24 ORGANISM_TAXID: 9606;                                                
SOURCE  25 CELL: ERYTHROCYTES;                                                  
SOURCE  26 MOL_ID: 6;                                                           
SOURCE  27 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  28 ORGANISM_COMMON: HUMAN;                                              
SOURCE  29 ORGANISM_TAXID: 9606;                                                
SOURCE  30 CELL: ERYTHROCYTES;                                                  
SOURCE  31 MOL_ID: 7;                                                           
SOURCE  32 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  33 ORGANISM_COMMON: HUMAN;                                              
SOURCE  34 ORGANISM_TAXID: 9606;                                                
SOURCE  35 CELL: ERYTHROCYTES;                                                  
SOURCE  36 MOL_ID: 8;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  38 ORGANISM_COMMON: HUMAN;                                              
SOURCE  39 ORGANISM_TAXID: 9606;                                                
SOURCE  40 CELL: ERYTHROCYTES;                                                  
SOURCE  41 MOL_ID: 9;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 CELL: ERYTHROCYTES;                                                  
SOURCE  46 MOL_ID: 10;                                                          
SOURCE  47 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  48 ORGANISM_COMMON: HUMAN;                                              
SOURCE  49 ORGANISM_TAXID: 9606;                                                
SOURCE  50 CELL: ERYTHROCYTES;                                                  
SOURCE  51 MOL_ID: 11;                                                          
SOURCE  52 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  53 ORGANISM_COMMON: HUMAN;                                              
SOURCE  54 ORGANISM_TAXID: 9606;                                                
SOURCE  55 CELL: ERYTHROCYTES;                                                  
SOURCE  56 MOL_ID: 12;                                                          
SOURCE  57 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  58 ORGANISM_COMMON: HUMAN;                                              
SOURCE  59 ORGANISM_TAXID: 9606;                                                
SOURCE  60 CELL: ERYTHROCYTES;                                                  
SOURCE  61 MOL_ID: 13;                                                          
SOURCE  62 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  63 ORGANISM_COMMON: HUMAN;                                              
SOURCE  64 ORGANISM_TAXID: 9606;                                                
SOURCE  65 CELL: ERYTHROCYTES;                                                  
SOURCE  66 MOL_ID: 14;                                                          
SOURCE  67 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  68 ORGANISM_COMMON: HUMAN;                                              
SOURCE  69 ORGANISM_TAXID: 9606;                                                
SOURCE  70 CELL: ERYTHROCYTES                                                   
KEYWDS    HYDROLASE, PROTEASOME, 20S, ADAAHX3L3VS, LIGAND, INHIBITOR, DRUG      
KEYWDS   2 DESIGN                                                               
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    P.C.A.DAFONSECA,E.P.MORRIS                                            
REVDAT   2   02-AUG-17 5A0Q    1                                                
REVDAT   1   30-DEC-15 5A0Q    0                                                
JRNL        AUTH   P.C.A.DA FONSECA,E.P.MORRIS                                  
JRNL        TITL   CRYO-EM REVEALS THE CONFORMATION OF A SUBSTRATE ANALOGUE IN  
JRNL        TITL 2 THE HUMAN 20S PROTEASOME CORE.                               
JRNL        REF    NAT.COMMUN.                   V.   6  7573 2015              
JRNL        REFN                   ESSN 2041-1723                               
JRNL        PMID   26133119                                                     
JRNL        DOI    10.1038/NCOMMS8573                                           
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.50 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : COOT, PHENIX, IMAGIC, SPIDER, TIGRIS      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : 3UNE                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : METHOD--FLEXIBLE                                 
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.500                          
REMARK   3   NUMBER OF PARTICLES               : 76500                          
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: DISORDERED REGIONS, NOT RECOVERED IN THE EM MAP,      
REMARK   3  WHERE NOT MODELED. SUBMISSION BASED ON EXPERIMENTAL DATA FROM       
REMARK   3  EMDB EMD-2981. (DEPOSITION ID: 13310).                              
REMARK   4                                                                      
REMARK   4 5A0Q COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE.                               
REMARK 100 THE DEPOSITION ID IS D_1290063660.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : CRYO EM                           
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : HUMAN 20S PROTEASOME CORE         
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.10                              
REMARK 245   SAMPLE SUPPORT DETAILS         : CARBON                            
REMARK 245   SAMPLE VITRIFICATION DETAILS   : VITRIFICATION 1 -- CRYOGEN-       
REMARK 245                                    ETHANE, HUMIDITY- 95,             
REMARK 245                                    TEMPERATURE- 120, INSTRUMENT-     
REMARK 245                                    FEI VITROBOT MARK III, METHOD-    
REMARK 245                                    BLOT 2. 5 SECONDS BEFORE          
REMARK 245                                    PLUNGING,                         
REMARK 245   SAMPLE BUFFER                  : 50 MM TRIS-HCL, 5 MM MGCL2 AND    
REMARK 245                                    1MM DITHIOTREITOL                 
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : THE POWER SPECTRA OF THE IMAGES   
REMARK 245  SELECTED FOR ANALYSIS HAD ISOTROPIC THON RINGS DIRECTLY OBSERVED    
REMARK 245  TO 4 ANGSTROMS OR BETTER                                            
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 04-FEB-14                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : 85.00                          
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : FEI FALCON II (4K X 4K)        
REMARK 245   MINIMUM DEFOCUS (NM)              : 1700.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3000.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 4.80                           
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 75000                          
REMARK 245   CALIBRATED MAGNIFICATION          : 134461                         
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : EACH EXPOSURE WAS RECORDED     
REMARK 245  AS 17 INDIVIDUAL FRAMES CAPTURED AT A RATE OF 0.056 SECONDS PER     
REMARK 245  FRAME, WITH AN ELECTRON DOSE OF 2.8 ELECTRONS PER SQUARE            
REMARK 245  ANGSTROM. DATA-SET RECORDED USING EPU SOFTWARE.                     
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 28-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N, O, P, Q, R, S,            
REMARK 350                    AND CHAINS: T, U, V, W, X, Y, Z, a, b             
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     ARG A     3                                                      
REMARK 465     GLY A     4                                                      
REMARK 465     SER A     5                                                      
REMARK 465     SER A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     GLY A     8                                                      
REMARK 465     PHE A     9                                                      
REMARK 465     GLN A    53                                                      
REMARK 465     LYS A    54                                                      
REMARK 465     LYS A    55                                                      
REMARK 465     VAL A    56                                                      
REMARK 465     PRO A    57                                                      
REMARK 465     ASP A    58                                                      
REMARK 465     LYS A    59                                                      
REMARK 465     LEU A    60                                                      
REMARK 465     LEU A    61                                                      
REMARK 465     ASP A    62                                                      
REMARK 465     SER A    63                                                      
REMARK 465     SER A    64                                                      
REMARK 465     THR A    65                                                      
REMARK 465     VAL A    66                                                      
REMARK 465     THR A    67                                                      
REMARK 465     GLU A   145                                                      
REMARK 465     GLU A   146                                                      
REMARK 465     GLN A   147                                                      
REMARK 465     VAL A   183                                                      
REMARK 465     LYS A   184                                                      
REMARK 465     LYS A   185                                                      
REMARK 465     LYS A   186                                                      
REMARK 465     PHE A   187                                                      
REMARK 465     ASP A   188                                                      
REMARK 465     TRP A   189                                                      
REMARK 465     THR A   190                                                      
REMARK 465     PHE A   191                                                      
REMARK 465     GLU A   192                                                      
REMARK 465     GLU A   232                                                      
REMARK 465     ALA A   233                                                      
REMARK 465     GLU A   234                                                      
REMARK 465     ASP A   236                                                      
REMARK 465     ALA A   237                                                      
REMARK 465     HIS A   238                                                      
REMARK 465     LEU A   239                                                      
REMARK 465     VAL A   240                                                      
REMARK 465     ALA A   241                                                      
REMARK 465     LEU A   242                                                      
REMARK 465     ALA A   243                                                      
REMARK 465     GLU A   244                                                      
REMARK 465     ARG A   245                                                      
REMARK 465     ASP A   246                                                      
REMARK 465     MET B     0                                                      
REMARK 465     ALA B     1                                                      
REMARK 465     GLU B     2                                                      
REMARK 465     ARG B     3                                                      
REMARK 465     GLY B     4                                                      
REMARK 465     PHE B   198                                                      
REMARK 465     GLU B   199                                                      
REMARK 465     GLY B   200                                                      
REMARK 465     GLN B   201                                                      
REMARK 465     MET B   202                                                      
REMARK 465     THR B   203                                                      
REMARK 465     GLU B   204                                                      
REMARK 465     ASP B   205                                                      
REMARK 465     ASP B   227                                                      
REMARK 465     TYR B   228                                                      
REMARK 465     LEU B   229                                                      
REMARK 465     ALA B   230                                                      
REMARK 465     ALA B   231                                                      
REMARK 465     ILE B   232                                                      
REMARK 465     ALA B   233                                                      
REMARK 465     MET C     1                                                      
REMARK 465     GLU C    58                                                      
REMARK 465     VAL C    59                                                      
REMARK 465     PHE C    60                                                      
REMARK 465     PHE C    61                                                      
REMARK 465     SER C    62                                                      
REMARK 465     GLU C    63                                                      
REMARK 465     ALA C   245                                                      
REMARK 465     LYS C   246                                                      
REMARK 465     ALA C   247                                                      
REMARK 465     GLU C   248                                                      
REMARK 465     ARG C   249                                                      
REMARK 465     GLU C   250                                                      
REMARK 465     LYS C   251                                                      
REMARK 465     LYS C   252                                                      
REMARK 465     GLU C   253                                                      
REMARK 465     LYS C   254                                                      
REMARK 465     GLU C   255                                                      
REMARK 465     GLN C   256                                                      
REMARK 465     LYS C   257                                                      
REMARK 465     GLU C   258                                                      
REMARK 465     LYS C   259                                                      
REMARK 465     ASP C   260                                                      
REMARK 465     LYS C   261                                                      
REMARK 465     MET D     1                                                      
REMARK 465     SER D     2                                                      
REMARK 465     TYR D     3                                                      
REMARK 465     ASP D     4                                                      
REMARK 465     ASP D    55                                                      
REMARK 465     GLU D    56                                                      
REMARK 465     ARG D    57                                                      
REMARK 465     THR D    58                                                      
REMARK 465     VAL D    59                                                      
REMARK 465     ARG D    60                                                      
REMARK 465     LYS D    61                                                      
REMARK 465     ILE D    62                                                      
REMARK 465     PHE D   138                                                      
REMARK 465     ASP D   139                                                      
REMARK 465     THR D   177                                                      
REMARK 465     ASP D   178                                                      
REMARK 465     GLU D   179                                                      
REMARK 465     ALA D   180                                                      
REMARK 465     ILE D   181                                                      
REMARK 465     GLU D   182                                                      
REMARK 465     THR D   183                                                      
REMARK 465     LYS D   236                                                      
REMARK 465     GLU D   237                                                      
REMARK 465     GLU D   238                                                      
REMARK 465     ASN D   239                                                      
REMARK 465     GLU D   240                                                      
REMARK 465     LYS D   241                                                      
REMARK 465     LYS D   242                                                      
REMARK 465     LYS D   243                                                      
REMARK 465     GLN D   244                                                      
REMARK 465     LYS D   245                                                      
REMARK 465     LYS D   246                                                      
REMARK 465     ALA D   247                                                      
REMARK 465     SER D   248                                                      
REMARK 465     MET E     1                                                      
REMARK 465     PHE E     2                                                      
REMARK 465     LEU E     3                                                      
REMARK 465     THR E     4                                                      
REMARK 465     ARG E     5                                                      
REMARK 465     SER E     6                                                      
REMARK 465     GLU E     7                                                      
REMARK 465     TYR E     8                                                      
REMARK 465     ASP E     9                                                      
REMARK 465     ARG E    10                                                      
REMARK 465     GLY E    11                                                      
REMARK 465     VAL E    12                                                      
REMARK 465     GLU E   125                                                      
REMARK 465     GLU E   126                                                      
REMARK 465     ASP E   127                                                      
REMARK 465     ALA E   128                                                      
REMARK 465     ASP E   129                                                      
REMARK 465     PRO E   130                                                      
REMARK 465     GLY E   131                                                      
REMARK 465     ALA E   132                                                      
REMARK 465     MET E   133                                                      
REMARK 465     VAL E   237                                                      
REMARK 465     ILE E   238                                                      
REMARK 465     LYS E   239                                                      
REMARK 465     ASP E   240                                                      
REMARK 465     ILE E   241                                                      
REMARK 465     MET F     1                                                      
REMARK 465     PHE F     2                                                      
REMARK 465     ARG F     3                                                      
REMARK 465     ASN F     4                                                      
REMARK 465     GLN F     5                                                      
REMARK 465     ARG F    51                                                      
REMARK 465     ALA F    52                                                      
REMARK 465     GLN F    53                                                      
REMARK 465     SER F    54                                                      
REMARK 465     GLU F    55                                                      
REMARK 465     LEU F    56                                                      
REMARK 465     ALA F    57                                                      
REMARK 465     ALA F    58                                                      
REMARK 465     HIS F    59                                                      
REMARK 465     GLN F    60                                                      
REMARK 465     LYS F    61                                                      
REMARK 465     MET F   176                                                      
REMARK 465     SER F   177                                                      
REMARK 465     THR F   198                                                      
REMARK 465     LEU F   199                                                      
REMARK 465     PRO F   200                                                      
REMARK 465     ALA F   201                                                      
REMARK 465     GLU F   202                                                      
REMARK 465     GLN F   203                                                      
REMARK 465     ASP F   204                                                      
REMARK 465     LEU F   205                                                      
REMARK 465     THR F   206                                                      
REMARK 465     THR F   207                                                      
REMARK 465     LYS F   208                                                      
REMARK 465     ASP F   225                                                      
REMARK 465     ASP F   226                                                      
REMARK 465     ASP F   227                                                      
REMARK 465     ASP F   228                                                      
REMARK 465     VAL F   229                                                      
REMARK 465     SER F   230                                                      
REMARK 465     PRO F   231                                                      
REMARK 465     PHE F   232                                                      
REMARK 465     LEU F   233                                                      
REMARK 465     GLU F   234                                                      
REMARK 465     GLY F   235                                                      
REMARK 465     LEU F   236                                                      
REMARK 465     GLU F   237                                                      
REMARK 465     GLU F   238                                                      
REMARK 465     ARG F   239                                                      
REMARK 465     PRO F   240                                                      
REMARK 465     GLN F   241                                                      
REMARK 465     ARG F   242                                                      
REMARK 465     LYS F   243                                                      
REMARK 465     ALA F   244                                                      
REMARK 465     GLN F   245                                                      
REMARK 465     PRO F   246                                                      
REMARK 465     ALA F   247                                                      
REMARK 465     GLN F   248                                                      
REMARK 465     PRO F   249                                                      
REMARK 465     ALA F   250                                                      
REMARK 465     ASP F   251                                                      
REMARK 465     GLU F   252                                                      
REMARK 465     PRO F   253                                                      
REMARK 465     ALA F   254                                                      
REMARK 465     GLU F   255                                                      
REMARK 465     LYS F   256                                                      
REMARK 465     ALA F   257                                                      
REMARK 465     ASP F   258                                                      
REMARK 465     GLU F   259                                                      
REMARK 465     PRO F   260                                                      
REMARK 465     MET F   261                                                      
REMARK 465     GLU F   262                                                      
REMARK 465     HIS F   263                                                      
REMARK 465     MET G     0                                                      
REMARK 465     SER G     1                                                      
REMARK 465     SER G     2                                                      
REMARK 465     ILE G     3                                                      
REMARK 465     GLY G     4                                                      
REMARK 465     THR G     5                                                      
REMARK 465     GLY G     6                                                      
REMARK 465     TYR G     7                                                      
REMARK 465     LYS G    51                                                      
REMARK 465     LEU G    52                                                      
REMARK 465     VAL G    53                                                      
REMARK 465     LEU G    54                                                      
REMARK 465     SER G    55                                                      
REMARK 465     LYS G    56                                                      
REMARK 465     LEU G    57                                                      
REMARK 465     TYR G    58                                                      
REMARK 465     GLU G    59                                                      
REMARK 465     GLU G    60                                                      
REMARK 465     GLY G    61                                                      
REMARK 465     SER G    62                                                      
REMARK 465     ASN G    63                                                      
REMARK 465     LYS G    64                                                      
REMARK 465     ARG G    65                                                      
REMARK 465     ASP G   202                                                      
REMARK 465     GLU G   203                                                      
REMARK 465     VAL G   204                                                      
REMARK 465     LYS G   205                                                      
REMARK 465     ASP G   206                                                      
REMARK 465     LYS G   207                                                      
REMARK 465     TYR G   238                                                      
REMARK 465     ALA G   239                                                      
REMARK 465     LYS G   240                                                      
REMARK 465     GLU G   241                                                      
REMARK 465     SER G   242                                                      
REMARK 465     LEU G   243                                                      
REMARK 465     LYS G   244                                                      
REMARK 465     GLU G   245                                                      
REMARK 465     GLU G   246                                                      
REMARK 465     ASP G   247                                                      
REMARK 465     GLU G   248                                                      
REMARK 465     SER G   249                                                      
REMARK 465     ASP G   250                                                      
REMARK 465     ASP G   251                                                      
REMARK 465     ASP G   252                                                      
REMARK 465     ASN G   253                                                      
REMARK 465     MET G   254                                                      
REMARK 465     ASP H   104                                                      
REMARK 465     PRO H   105                                                      
REMARK 465     GLN H   106                                                      
REMARK 465     GLU H   107                                                      
REMARK 465     GLY H   108                                                      
REMARK 465     LEU H   189                                                      
REMARK 465     LEU H   190                                                      
REMARK 465     GLY H   191                                                      
REMARK 465     ASP H   192                                                      
REMARK 465     GLN H   193                                                      
REMARK 465     ILE H   194                                                      
REMARK 465     PRO H   195                                                      
REMARK 465     LYS H   196                                                      
REMARK 465     PHE H   197                                                      
REMARK 465     ALA H   198                                                      
REMARK 465     VAL H   199                                                      
REMARK 465     ALA H   200                                                      
REMARK 465     THR H   201                                                      
REMARK 465     LEU H   202                                                      
REMARK 465     PRO H   203                                                      
REMARK 465     PRO H   204                                                      
REMARK 465     ALA H   205                                                      
REMARK 465     ASN I   193                                                      
REMARK 465     LYS I   194                                                      
REMARK 465     LYS I   195                                                      
REMARK 465     GLY I   196                                                      
REMARK 465     THR I   197                                                      
REMARK 465     ARG I   198                                                      
REMARK 465     LEU I   199                                                      
REMARK 465     GLY I   200                                                      
REMARK 465     ARG I   201                                                      
REMARK 465     THR I   208                                                      
REMARK 465     THR I   209                                                      
REMARK 465     ALA I   210                                                      
REMARK 465     VAL I   211                                                      
REMARK 465     LEU I   212                                                      
REMARK 465     THR I   213                                                      
REMARK 465     GLU I   214                                                      
REMARK 465     LYS I   215                                                      
REMARK 465     ILE I   216                                                      
REMARK 465     THR I   217                                                      
REMARK 465     PRO I   218                                                      
REMARK 465     LEU I   219                                                      
REMARK 465     GLU I   220                                                      
REMARK 465     ILE I   221                                                      
REMARK 465     GLU I   222                                                      
REMARK 465     VAL I   223                                                      
REMARK 465     LEU I   224                                                      
REMARK 465     GLU I   225                                                      
REMARK 465     GLU I   226                                                      
REMARK 465     THR I   227                                                      
REMARK 465     VAL I   228                                                      
REMARK 465     GLN I   229                                                      
REMARK 465     THR I   230                                                      
REMARK 465     MET I   231                                                      
REMARK 465     ASP I   232                                                      
REMARK 465     THR I   233                                                      
REMARK 465     SER I   234                                                      
REMARK 465     SER J     1                                                      
REMARK 465     ILE J     2                                                      
REMARK 465     MET J     3                                                      
REMARK 465     SER J     4                                                      
REMARK 465     TYR J     5                                                      
REMARK 465     MET J    44                                                      
REMARK 465     GLY J    45                                                      
REMARK 465     ASP J    46                                                      
REMARK 465     ARG J    47                                                      
REMARK 465     LEU J   125                                                      
REMARK 465     ILE J   126                                                      
REMARK 465     GLY J   127                                                      
REMARK 465     CYS J   128                                                      
REMARK 465     PRO J   129                                                      
REMARK 465     MET J   130                                                      
REMARK 465     VAL J   131                                                      
REMARK 465     THR J   132                                                      
REMARK 465     ASP J   133                                                      
REMARK 465     ALA J   142                                                      
REMARK 465     GLU J   143                                                      
REMARK 465     ARG J   197                                                      
REMARK 465     THR J   198                                                      
REMARK 465     LEU J   199                                                      
REMARK 465     LYS J   200                                                      
REMARK 465     ALA J   201                                                      
REMARK 465     ARG J   202                                                      
REMARK 465     MET J   203                                                      
REMARK 465     ASP J   204                                                      
REMARK 465     MET K     1                                                      
REMARK 465     GLU K     2                                                      
REMARK 465     ASP K   192                                                      
REMARK 465     ASN K   193                                                      
REMARK 465     ILE K   194                                                      
REMARK 465     SER K   195                                                      
REMARK 465     PHE K   196                                                      
REMARK 465     PRO K   197                                                      
REMARK 465     LYS K   198                                                      
REMARK 465     GLN K   199                                                      
REMARK 465     GLY K   200                                                      
REMARK 465     SER K   201                                                      
REMARK 465     LYS L   106                                                      
REMARK 465     ARG L   107                                                      
REMARK 465     LEU L   195                                                      
REMARK 465     HIS L   196                                                      
REMARK 465     GLU L   197                                                      
REMARK 465     LYS L   198                                                      
REMARK 465     TYR L   199                                                      
REMARK 465     SER L   200                                                      
REMARK 465     GLY L   201                                                      
REMARK 465     SER L   202                                                      
REMARK 465     THR L   203                                                      
REMARK 465     PRO L   204                                                      
REMARK 465     ARG M     1                                                      
REMARK 465     PHE M     2                                                      
REMARK 465     SER M     3                                                      
REMARK 465     PRO M     4                                                      
REMARK 465     TYR M     5                                                      
REMARK 465     VAL M     6                                                      
REMARK 465     PHE M     7                                                      
REMARK 465     PHE M   155                                                      
REMARK 465     LYS M   156                                                      
REMARK 465     ASN M   157                                                      
REMARK 465     MET M   158                                                      
REMARK 465     GLN M   159                                                      
REMARK 465     ASN M   160                                                      
REMARK 465     VAL M   161                                                      
REMARK 465     GLU M   162                                                      
REMARK 465     GLU M   206                                                      
REMARK 465     THR M   207                                                      
REMARK 465     VAL M   208                                                      
REMARK 465     SER M   209                                                      
REMARK 465     LEU M   210                                                      
REMARK 465     ARG M   211                                                      
REMARK 465     LYS M   212                                                      
REMARK 465     ASP M   213                                                      
REMARK 465     THR N     1                                                      
REMARK 465     GLN N     2                                                      
REMARK 465     ASN N     3                                                      
REMARK 465     GLY N    78                                                      
REMARK 465     ASP N    79                                                      
REMARK 465     GLY N    80                                                      
REMARK 465     HIS N    81                                                      
REMARK 465     SER N    82                                                      
REMARK 465     TYR N    83                                                      
REMARK 465     LEU N   176                                                      
REMARK 465     TYR N   177                                                      
REMARK 465     TYR N   178                                                      
REMARK 465     ARG N   179                                                      
REMARK 465     ASP N   180                                                      
REMARK 465     ALA N   181                                                      
REMARK 465     ARG N   182                                                      
REMARK 465     GLY N   201                                                      
REMARK 465     PRO N   202                                                      
REMARK 465     LEU N   203                                                      
REMARK 465     SER N   204                                                      
REMARK 465     THR N   205                                                      
REMARK 465     GLU N   206                                                      
REMARK 465     THR N   207                                                      
REMARK 465     ASN N   208                                                      
REMARK 465     TRP N   209                                                      
REMARK 465     ASP N   210                                                      
REMARK 465     ILE N   211                                                      
REMARK 465     ALA N   212                                                      
REMARK 465     HIS N   213                                                      
REMARK 465     MET N   214                                                      
REMARK 465     ILE N   215                                                      
REMARK 465     SER N   216                                                      
REMARK 465     GLY N   217                                                      
REMARK 465     PHE N   218                                                      
REMARK 465     GLU N   219                                                      
REMARK 465     MET O     1                                                      
REMARK 465     SER O     2                                                      
REMARK 465     ARG O     3                                                      
REMARK 465     GLY O     4                                                      
REMARK 465     SER O     5                                                      
REMARK 465     SER O     6                                                      
REMARK 465     ALA O     7                                                      
REMARK 465     GLY O     8                                                      
REMARK 465     PHE O     9                                                      
REMARK 465     GLN O    53                                                      
REMARK 465     LYS O    54                                                      
REMARK 465     LYS O    55                                                      
REMARK 465     VAL O    56                                                      
REMARK 465     PRO O    57                                                      
REMARK 465     ASP O    58                                                      
REMARK 465     LYS O    59                                                      
REMARK 465     LEU O    60                                                      
REMARK 465     LEU O    61                                                      
REMARK 465     ASP O    62                                                      
REMARK 465     SER O    63                                                      
REMARK 465     SER O    64                                                      
REMARK 465     THR O    65                                                      
REMARK 465     VAL O    66                                                      
REMARK 465     THR O    67                                                      
REMARK 465     GLU O   145                                                      
REMARK 465     GLU O   146                                                      
REMARK 465     GLN O   147                                                      
REMARK 465     VAL O   183                                                      
REMARK 465     LYS O   184                                                      
REMARK 465     LYS O   185                                                      
REMARK 465     LYS O   186                                                      
REMARK 465     PHE O   187                                                      
REMARK 465     ASP O   188                                                      
REMARK 465     TRP O   189                                                      
REMARK 465     THR O   190                                                      
REMARK 465     PHE O   191                                                      
REMARK 465     GLU O   192                                                      
REMARK 465     GLU O   232                                                      
REMARK 465     ALA O   233                                                      
REMARK 465     GLU O   234                                                      
REMARK 465     ASP O   236                                                      
REMARK 465     ALA O   237                                                      
REMARK 465     HIS O   238                                                      
REMARK 465     LEU O   239                                                      
REMARK 465     VAL O   240                                                      
REMARK 465     ALA O   241                                                      
REMARK 465     LEU O   242                                                      
REMARK 465     ALA O   243                                                      
REMARK 465     GLU O   244                                                      
REMARK 465     ARG O   245                                                      
REMARK 465     ASP O   246                                                      
REMARK 465     MET P     0                                                      
REMARK 465     ALA P     1                                                      
REMARK 465     GLU P     2                                                      
REMARK 465     ARG P     3                                                      
REMARK 465     GLY P     4                                                      
REMARK 465     PHE P   198                                                      
REMARK 465     GLU P   199                                                      
REMARK 465     GLY P   200                                                      
REMARK 465     GLN P   201                                                      
REMARK 465     MET P   202                                                      
REMARK 465     THR P   203                                                      
REMARK 465     GLU P   204                                                      
REMARK 465     ASP P   205                                                      
REMARK 465     ASP P   227                                                      
REMARK 465     TYR P   228                                                      
REMARK 465     LEU P   229                                                      
REMARK 465     ALA P   230                                                      
REMARK 465     ALA P   231                                                      
REMARK 465     ILE P   232                                                      
REMARK 465     ALA P   233                                                      
REMARK 465     MET Q     1                                                      
REMARK 465     GLU Q    58                                                      
REMARK 465     VAL Q    59                                                      
REMARK 465     PHE Q    60                                                      
REMARK 465     PHE Q    61                                                      
REMARK 465     SER Q    62                                                      
REMARK 465     GLU Q    63                                                      
REMARK 465     ALA Q   245                                                      
REMARK 465     LYS Q   246                                                      
REMARK 465     ALA Q   247                                                      
REMARK 465     GLU Q   248                                                      
REMARK 465     ARG Q   249                                                      
REMARK 465     GLU Q   250                                                      
REMARK 465     LYS Q   251                                                      
REMARK 465     LYS Q   252                                                      
REMARK 465     GLU Q   253                                                      
REMARK 465     LYS Q   254                                                      
REMARK 465     GLU Q   255                                                      
REMARK 465     GLN Q   256                                                      
REMARK 465     LYS Q   257                                                      
REMARK 465     GLU Q   258                                                      
REMARK 465     LYS Q   259                                                      
REMARK 465     ASP Q   260                                                      
REMARK 465     LYS Q   261                                                      
REMARK 465     MET R     1                                                      
REMARK 465     SER R     2                                                      
REMARK 465     TYR R     3                                                      
REMARK 465     ASP R     4                                                      
REMARK 465     ASP R    55                                                      
REMARK 465     GLU R    56                                                      
REMARK 465     ARG R    57                                                      
REMARK 465     THR R    58                                                      
REMARK 465     VAL R    59                                                      
REMARK 465     ARG R    60                                                      
REMARK 465     LYS R    61                                                      
REMARK 465     ILE R    62                                                      
REMARK 465     PHE R   138                                                      
REMARK 465     ASP R   139                                                      
REMARK 465     THR R   177                                                      
REMARK 465     ASP R   178                                                      
REMARK 465     GLU R   179                                                      
REMARK 465     ALA R   180                                                      
REMARK 465     ILE R   181                                                      
REMARK 465     GLU R   182                                                      
REMARK 465     THR R   183                                                      
REMARK 465     LYS R   236                                                      
REMARK 465     GLU R   237                                                      
REMARK 465     GLU R   238                                                      
REMARK 465     ASN R   239                                                      
REMARK 465     GLU R   240                                                      
REMARK 465     LYS R   241                                                      
REMARK 465     LYS R   242                                                      
REMARK 465     LYS R   243                                                      
REMARK 465     GLN R   244                                                      
REMARK 465     LYS R   245                                                      
REMARK 465     LYS R   246                                                      
REMARK 465     ALA R   247                                                      
REMARK 465     SER R   248                                                      
REMARK 465     MET S     1                                                      
REMARK 465     PHE S     2                                                      
REMARK 465     LEU S     3                                                      
REMARK 465     THR S     4                                                      
REMARK 465     ARG S     5                                                      
REMARK 465     SER S     6                                                      
REMARK 465     GLU S     7                                                      
REMARK 465     TYR S     8                                                      
REMARK 465     ASP S     9                                                      
REMARK 465     ARG S    10                                                      
REMARK 465     GLY S    11                                                      
REMARK 465     VAL S    12                                                      
REMARK 465     GLU S   125                                                      
REMARK 465     GLU S   126                                                      
REMARK 465     ASP S   127                                                      
REMARK 465     ALA S   128                                                      
REMARK 465     ASP S   129                                                      
REMARK 465     PRO S   130                                                      
REMARK 465     GLY S   131                                                      
REMARK 465     ALA S   132                                                      
REMARK 465     MET S   133                                                      
REMARK 465     VAL S   237                                                      
REMARK 465     ILE S   238                                                      
REMARK 465     LYS S   239                                                      
REMARK 465     ASP S   240                                                      
REMARK 465     ILE S   241                                                      
REMARK 465     MET T     1                                                      
REMARK 465     PHE T     2                                                      
REMARK 465     ARG T     3                                                      
REMARK 465     ASN T     4                                                      
REMARK 465     GLN T     5                                                      
REMARK 465     ARG T    51                                                      
REMARK 465     ALA T    52                                                      
REMARK 465     GLN T    53                                                      
REMARK 465     SER T    54                                                      
REMARK 465     GLU T    55                                                      
REMARK 465     LEU T    56                                                      
REMARK 465     ALA T    57                                                      
REMARK 465     ALA T    58                                                      
REMARK 465     HIS T    59                                                      
REMARK 465     GLN T    60                                                      
REMARK 465     LYS T    61                                                      
REMARK 465     MET T   176                                                      
REMARK 465     SER T   177                                                      
REMARK 465     THR T   198                                                      
REMARK 465     LEU T   199                                                      
REMARK 465     PRO T   200                                                      
REMARK 465     ALA T   201                                                      
REMARK 465     GLU T   202                                                      
REMARK 465     GLN T   203                                                      
REMARK 465     ASP T   204                                                      
REMARK 465     LEU T   205                                                      
REMARK 465     THR T   206                                                      
REMARK 465     THR T   207                                                      
REMARK 465     LYS T   208                                                      
REMARK 465     ASP T   225                                                      
REMARK 465     ASP T   226                                                      
REMARK 465     ASP T   227                                                      
REMARK 465     ASP T   228                                                      
REMARK 465     VAL T   229                                                      
REMARK 465     SER T   230                                                      
REMARK 465     PRO T   231                                                      
REMARK 465     PHE T   232                                                      
REMARK 465     LEU T   233                                                      
REMARK 465     GLU T   234                                                      
REMARK 465     GLY T   235                                                      
REMARK 465     LEU T   236                                                      
REMARK 465     GLU T   237                                                      
REMARK 465     GLU T   238                                                      
REMARK 465     ARG T   239                                                      
REMARK 465     PRO T   240                                                      
REMARK 465     GLN T   241                                                      
REMARK 465     ARG T   242                                                      
REMARK 465     LYS T   243                                                      
REMARK 465     ALA T   244                                                      
REMARK 465     GLN T   245                                                      
REMARK 465     PRO T   246                                                      
REMARK 465     ALA T   247                                                      
REMARK 465     GLN T   248                                                      
REMARK 465     PRO T   249                                                      
REMARK 465     ALA T   250                                                      
REMARK 465     ASP T   251                                                      
REMARK 465     GLU T   252                                                      
REMARK 465     PRO T   253                                                      
REMARK 465     ALA T   254                                                      
REMARK 465     GLU T   255                                                      
REMARK 465     LYS T   256                                                      
REMARK 465     ALA T   257                                                      
REMARK 465     ASP T   258                                                      
REMARK 465     GLU T   259                                                      
REMARK 465     PRO T   260                                                      
REMARK 465     MET T   261                                                      
REMARK 465     GLU T   262                                                      
REMARK 465     HIS T   263                                                      
REMARK 465     MET U     0                                                      
REMARK 465     SER U     1                                                      
REMARK 465     SER U     2                                                      
REMARK 465     ILE U     3                                                      
REMARK 465     GLY U     4                                                      
REMARK 465     THR U     5                                                      
REMARK 465     GLY U     6                                                      
REMARK 465     TYR U     7                                                      
REMARK 465     LYS U    51                                                      
REMARK 465     LEU U    52                                                      
REMARK 465     VAL U    53                                                      
REMARK 465     LEU U    54                                                      
REMARK 465     SER U    55                                                      
REMARK 465     LYS U    56                                                      
REMARK 465     LEU U    57                                                      
REMARK 465     TYR U    58                                                      
REMARK 465     GLU U    59                                                      
REMARK 465     GLU U    60                                                      
REMARK 465     GLY U    61                                                      
REMARK 465     SER U    62                                                      
REMARK 465     ASN U    63                                                      
REMARK 465     LYS U    64                                                      
REMARK 465     ARG U    65                                                      
REMARK 465     ASP U   202                                                      
REMARK 465     GLU U   203                                                      
REMARK 465     VAL U   204                                                      
REMARK 465     LYS U   205                                                      
REMARK 465     ASP U   206                                                      
REMARK 465     LYS U   207                                                      
REMARK 465     TYR U   238                                                      
REMARK 465     ALA U   239                                                      
REMARK 465     LYS U   240                                                      
REMARK 465     GLU U   241                                                      
REMARK 465     SER U   242                                                      
REMARK 465     LEU U   243                                                      
REMARK 465     LYS U   244                                                      
REMARK 465     GLU U   245                                                      
REMARK 465     GLU U   246                                                      
REMARK 465     ASP U   247                                                      
REMARK 465     GLU U   248                                                      
REMARK 465     SER U   249                                                      
REMARK 465     ASP U   250                                                      
REMARK 465     ASP U   251                                                      
REMARK 465     ASP U   252                                                      
REMARK 465     ASN U   253                                                      
REMARK 465     MET U   254                                                      
REMARK 465     ASP V   104                                                      
REMARK 465     PRO V   105                                                      
REMARK 465     GLN V   106                                                      
REMARK 465     GLU V   107                                                      
REMARK 465     GLY V   108                                                      
REMARK 465     LEU V   189                                                      
REMARK 465     LEU V   190                                                      
REMARK 465     GLY V   191                                                      
REMARK 465     ASP V   192                                                      
REMARK 465     GLN V   193                                                      
REMARK 465     ILE V   194                                                      
REMARK 465     PRO V   195                                                      
REMARK 465     LYS V   196                                                      
REMARK 465     PHE V   197                                                      
REMARK 465     ALA V   198                                                      
REMARK 465     VAL V   199                                                      
REMARK 465     ALA V   200                                                      
REMARK 465     THR V   201                                                      
REMARK 465     LEU V   202                                                      
REMARK 465     PRO V   203                                                      
REMARK 465     PRO V   204                                                      
REMARK 465     ALA V   205                                                      
REMARK 465     ASN W   193                                                      
REMARK 465     LYS W   194                                                      
REMARK 465     LYS W   195                                                      
REMARK 465     GLY W   196                                                      
REMARK 465     THR W   197                                                      
REMARK 465     ARG W   198                                                      
REMARK 465     LEU W   199                                                      
REMARK 465     GLY W   200                                                      
REMARK 465     ARG W   201                                                      
REMARK 465     THR W   208                                                      
REMARK 465     THR W   209                                                      
REMARK 465     ALA W   210                                                      
REMARK 465     VAL W   211                                                      
REMARK 465     LEU W   212                                                      
REMARK 465     THR W   213                                                      
REMARK 465     GLU W   214                                                      
REMARK 465     LYS W   215                                                      
REMARK 465     ILE W   216                                                      
REMARK 465     THR W   217                                                      
REMARK 465     PRO W   218                                                      
REMARK 465     LEU W   219                                                      
REMARK 465     GLU W   220                                                      
REMARK 465     ILE W   221                                                      
REMARK 465     GLU W   222                                                      
REMARK 465     VAL W   223                                                      
REMARK 465     LEU W   224                                                      
REMARK 465     GLU W   225                                                      
REMARK 465     GLU W   226                                                      
REMARK 465     THR W   227                                                      
REMARK 465     VAL W   228                                                      
REMARK 465     GLN W   229                                                      
REMARK 465     THR W   230                                                      
REMARK 465     MET W   231                                                      
REMARK 465     ASP W   232                                                      
REMARK 465     THR W   233                                                      
REMARK 465     SER W   234                                                      
REMARK 465     SER X     1                                                      
REMARK 465     ILE X     2                                                      
REMARK 465     MET X     3                                                      
REMARK 465     SER X     4                                                      
REMARK 465     TYR X     5                                                      
REMARK 465     MET X    44                                                      
REMARK 465     GLY X    45                                                      
REMARK 465     ASP X    46                                                      
REMARK 465     ARG X    47                                                      
REMARK 465     LEU X   125                                                      
REMARK 465     ILE X   126                                                      
REMARK 465     GLY X   127                                                      
REMARK 465     CYS X   128                                                      
REMARK 465     PRO X   129                                                      
REMARK 465     MET X   130                                                      
REMARK 465     VAL X   131                                                      
REMARK 465     THR X   132                                                      
REMARK 465     ASP X   133                                                      
REMARK 465     ALA X   142                                                      
REMARK 465     GLU X   143                                                      
REMARK 465     ARG X   197                                                      
REMARK 465     THR X   198                                                      
REMARK 465     LEU X   199                                                      
REMARK 465     LYS X   200                                                      
REMARK 465     ALA X   201                                                      
REMARK 465     ARG X   202                                                      
REMARK 465     MET X   203                                                      
REMARK 465     ASP X   204                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     GLU Y     2                                                      
REMARK 465     ASP Y   192                                                      
REMARK 465     ASN Y   193                                                      
REMARK 465     ILE Y   194                                                      
REMARK 465     SER Y   195                                                      
REMARK 465     PHE Y   196                                                      
REMARK 465     PRO Y   197                                                      
REMARK 465     LYS Y   198                                                      
REMARK 465     GLN Y   199                                                      
REMARK 465     GLY Y   200                                                      
REMARK 465     SER Y   201                                                      
REMARK 465     LYS Z   106                                                      
REMARK 465     ARG Z   107                                                      
REMARK 465     LEU Z   195                                                      
REMARK 465     HIS Z   196                                                      
REMARK 465     GLU Z   197                                                      
REMARK 465     LYS Z   198                                                      
REMARK 465     TYR Z   199                                                      
REMARK 465     SER Z   200                                                      
REMARK 465     GLY Z   201                                                      
REMARK 465     SER Z   202                                                      
REMARK 465     THR Z   203                                                      
REMARK 465     PRO Z   204                                                      
REMARK 465     ARG a     1                                                      
REMARK 465     PHE a     2                                                      
REMARK 465     SER a     3                                                      
REMARK 465     PRO a     4                                                      
REMARK 465     TYR a     5                                                      
REMARK 465     VAL a     6                                                      
REMARK 465     PHE a     7                                                      
REMARK 465     PHE a   155                                                      
REMARK 465     LYS a   156                                                      
REMARK 465     ASN a   157                                                      
REMARK 465     MET a   158                                                      
REMARK 465     GLN a   159                                                      
REMARK 465     ASN a   160                                                      
REMARK 465     VAL a   161                                                      
REMARK 465     GLU a   162                                                      
REMARK 465     GLU a   206                                                      
REMARK 465     THR a   207                                                      
REMARK 465     VAL a   208                                                      
REMARK 465     SER a   209                                                      
REMARK 465     LEU a   210                                                      
REMARK 465     ARG a   211                                                      
REMARK 465     LYS a   212                                                      
REMARK 465     ASP a   213                                                      
REMARK 465     THR b     1                                                      
REMARK 465     GLN b     2                                                      
REMARK 465     ASN b     3                                                      
REMARK 465     GLY b    78                                                      
REMARK 465     ASP b    79                                                      
REMARK 465     GLY b    80                                                      
REMARK 465     HIS b    81                                                      
REMARK 465     SER b    82                                                      
REMARK 465     TYR b    83                                                      
REMARK 465     LEU b   176                                                      
REMARK 465     TYR b   177                                                      
REMARK 465     TYR b   178                                                      
REMARK 465     ARG b   179                                                      
REMARK 465     ASP b   180                                                      
REMARK 465     ALA b   181                                                      
REMARK 465     ARG b   182                                                      
REMARK 465     GLY b   201                                                      
REMARK 465     PRO b   202                                                      
REMARK 465     LEU b   203                                                      
REMARK 465     SER b   204                                                      
REMARK 465     THR b   205                                                      
REMARK 465     GLU b   206                                                      
REMARK 465     THR b   207                                                      
REMARK 465     ASN b   208                                                      
REMARK 465     TRP b   209                                                      
REMARK 465     ASP b   210                                                      
REMARK 465     ILE b   211                                                      
REMARK 465     ALA b   212                                                      
REMARK 465     HIS b   213                                                      
REMARK 465     MET b   214                                                      
REMARK 465     ILE b   215                                                      
REMARK 465     SER b   216                                                      
REMARK 465     GLY b   217                                                      
REMARK 465     PHE b   218                                                      
REMARK 465     GLU b   219                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ILE A 235    O                                                   
REMARK 470     LYS B 226    O                                                   
REMARK 470     GLU C 244    O                                                   
REMARK 470     GLU D 235    O                                                   
REMARK 470     GLU E 236    O                                                   
REMARK 470     LYS G 237    O                                                   
REMARK 470     VAL H 188    O                                                   
REMARK 470     THR J 196    O                                                   
REMARK 470     LEU K 191    O                                                   
REMARK 470     ASP L 194    O                                                   
REMARK 470     GLU M 205    O                                                   
REMARK 470     GLU N 200    O                                                   
REMARK 470     ILE O 235    O                                                   
REMARK 470     LYS P 226    O                                                   
REMARK 470     GLU Q 244    O                                                   
REMARK 470     GLU R 235    O                                                   
REMARK 470     GLU S 236    O                                                   
REMARK 470     LYS U 237    O                                                   
REMARK 470     VAL V 188    O                                                   
REMARK 470     THR X 196    O                                                   
REMARK 470     LEU Y 191    O                                                   
REMARK 470     ASP Z 194    O                                                   
REMARK 470     GLU a 205    O                                                   
REMARK 470     GLU b 200    O                                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    SER K    23     OD1  ASN K    24              0.70            
REMARK 500   O    SER Y    23     OD1  ASN Y    24              0.70            
REMARK 500   O    VAL J   137     OH   TYR J   146              0.98            
REMARK 500   O    VAL X   137     OH   TYR X   146              0.98            
REMARK 500   NH1  ARG J    26     CB   MET J    33              1.39            
REMARK 500   NH1  ARG X    26     CB   MET X    33              1.39            
REMARK 500   ND2  ASN V    28     OG1  THR V    31              1.43            
REMARK 500   OG   SER V    18     O    ARG V    29              1.43            
REMARK 500   OG   SER H    18     O    ARG H    29              1.43            
REMARK 500   ND2  ASN H    28     OG1  THR H    31              1.43            
REMARK 500   OE1  GLU L    36     CD2  LEU L    42              1.55            
REMARK 500   OE1  GLU Z    36     CD2  LEU Z    42              1.56            
REMARK 500   CG   ASN J    17     CZ   PHE J   116              1.56            
REMARK 500   CG   ASN X    17     CZ   PHE X   116              1.56            
REMARK 500   OG1  THR S   219     CE1  HIS S   227              1.61            
REMARK 500   OG1  THR E   219     CE1  HIS E   227              1.61            
REMARK 500   O    ARG U    40     SD   MET U   181              1.64            
REMARK 500   O    ARG G    40     SD   MET G   181              1.64            
REMARK 500   C    SER K    23     OD1  ASN K    24              1.67            
REMARK 500   C    SER Y    23     OD1  ASN Y    24              1.67            
REMARK 500   CB   ASN J    17     CE2  PHE J   116              1.68            
REMARK 500   CB   ASN X    17     CE2  PHE X   116              1.68            
REMARK 500   CG   ASN J    17     CE2  PHE J   116              1.69            
REMARK 500   CG   ASN X    17     CE2  PHE X   116              1.69            
REMARK 500   O    SER K    23     CG   ASN K    24              1.72            
REMARK 500   O    SER Y    23     CG   ASN Y    24              1.72            
REMARK 500   OD1  ASP T   100     OG   SER b    90              1.72            
REMARK 500   OD1  ASP F   100     OG   SER N    90              1.72            
REMARK 500   CE1  PHE N    16     N    ARG N   166              1.74            
REMARK 500   CE1  PHE b    16     N    ARG b   166              1.74            
REMARK 500   CG2  ILE D   188     CZ   TYR D   228              1.74            
REMARK 500   CG2  ILE R   188     CZ   TYR R   228              1.74            
REMARK 500   ND2  ASN J    17     CE2  PHE J   116              1.76            
REMARK 500   ND2  ASN X    17     CE2  PHE X   116              1.76            
REMARK 500   CA   TYR O   103     NH2  ARG W    81              1.78            
REMARK 500   CA   TYR A   103     NH2  ARG I    81              1.78            
REMARK 500   OG1  THR E   219     NE2  HIS E   227              1.80            
REMARK 500   CB   PRO b     4     OD2  ASP b    56              1.80            
REMARK 500   CB   PRO N     4     OD2  ASP N    56              1.80            
REMARK 500   OG1  THR S   219     NE2  HIS S   227              1.80            
REMARK 500   CE   MET N    26     NH1  ARG N   186              1.81            
REMARK 500   CE   MET b    26     NH1  ARG b   186              1.82            
REMARK 500   CZ   PHE N    16     N    ARG N   166              1.83            
REMARK 500   CZ   PHE b    16     N    ARG b   166              1.83            
REMARK 500   CB   ALA L    50     OH   TYR M    97              1.84            
REMARK 500   CB   ALA Z    50     OH   TYR a    97              1.84            
REMARK 500   OD1  ASP K    52     OH   TYR L    88              1.85            
REMARK 500   OD1  ASP Y    52     OH   TYR Z    88              1.85            
REMARK 500   O    ASP D   184     CD1  ILE D   188              1.86            
REMARK 500   O    ASP R   184     CD1  ILE R   188              1.86            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     167 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    PRO I 123   CD    PRO I 123   N      -0.107                       
REMARK 500    THR L   1   C     THR L   2   N       0.149                       
REMARK 500    GLN L 162   CD    GLN L 162   OE1     0.134                       
REMARK 500    PRO W 123   CD    PRO W 123   N      -0.107                       
REMARK 500    THR Z   1   C     THR Z   2   N       0.149                       
REMARK 500    GLN Z 162   CD    GLN Z 162   OE1     0.134                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    TYR A  27   CB  -  CG  -  CD2 ANGL. DEV. =  -4.6 DEGREES          
REMARK 500    TYR A  27   CB  -  CG  -  CD1 ANGL. DEV. =   4.5 DEGREES          
REMARK 500    TYR B  23   CB  -  CG  -  CD2 ANGL. DEV. =  -4.1 DEGREES          
REMARK 500    TYR B  23   CB  -  CG  -  CD1 ANGL. DEV. =   3.8 DEGREES          
REMARK 500    TYR B 120   CB  -  CG  -  CD2 ANGL. DEV. =  -4.7 DEGREES          
REMARK 500    TYR B 120   CB  -  CG  -  CD1 ANGL. DEV. =   4.3 DEGREES          
REMARK 500    PRO B 143   C   -  N   -  CD  ANGL. DEV. = -19.5 DEGREES          
REMARK 500    SER C 153   N   -  CA  -  C   ANGL. DEV. = -21.7 DEGREES          
REMARK 500    TYR D  21   CB  -  CG  -  CD2 ANGL. DEV. =  -3.9 DEGREES          
REMARK 500    MET E  59   CG  -  SD  -  CE  ANGL. DEV. = -11.0 DEGREES          
REMARK 500    GLY E 124   N   -  CA  -  C   ANGL. DEV. = -16.3 DEGREES          
REMARK 500    PHE F 179   CB  -  CG  -  CD1 ANGL. DEV. =   4.6 DEGREES          
REMARK 500    TYR F 224   CB  -  CG  -  CD2 ANGL. DEV. =  -4.2 DEGREES          
REMARK 500    TYR F 224   CB  -  CG  -  CD1 ANGL. DEV. =   4.0 DEGREES          
REMARK 500    TYR G  25   CB  -  CG  -  CD2 ANGL. DEV. =  -4.6 DEGREES          
REMARK 500    PHE H   8   N   -  CA  -  C   ANGL. DEV. =  19.5 DEGREES          
REMARK 500    GLY H  47   N   -  CA  -  C   ANGL. DEV. = -23.2 DEGREES          
REMARK 500    TYR H  61   CB  -  CG  -  CD2 ANGL. DEV. =  -3.7 DEGREES          
REMARK 500    GLY H  97   N   -  CA  -  C   ANGL. DEV. = -16.6 DEGREES          
REMARK 500    ILE H 179   N   -  CA  -  C   ANGL. DEV. = -18.8 DEGREES          
REMARK 500    THR I 119   N   -  CA  -  CB  ANGL. DEV. =  12.9 DEGREES          
REMARK 500    THR I 119   N   -  CA  -  C   ANGL. DEV. = -19.7 DEGREES          
REMARK 500    TYR I 189   N   -  CA  -  C   ANGL. DEV. =  16.4 DEGREES          
REMARK 500    GLY J  54   N   -  CA  -  C   ANGL. DEV. = -16.9 DEGREES          
REMARK 500    PRO J 101   C   -  N   -  CD  ANGL. DEV. =  12.6 DEGREES          
REMARK 500    MET K  38   CG  -  SD  -  CE  ANGL. DEV. = -13.0 DEGREES          
REMARK 500    SER K 152   N   -  CA  -  CB  ANGL. DEV. =  11.3 DEGREES          
REMARK 500    THR L   1   O   -  C   -  N   ANGL. DEV. = -11.6 DEGREES          
REMARK 500    THR L   2   C   -  N   -  CA  ANGL. DEV. =  15.4 DEGREES          
REMARK 500    TYR N  62   CB  -  CG  -  CD2 ANGL. DEV. =  -4.1 DEGREES          
REMARK 500    TYR N  62   CB  -  CG  -  CD1 ANGL. DEV. =   3.7 DEGREES          
REMARK 500    TYR O  27   CB  -  CG  -  CD2 ANGL. DEV. =  -4.6 DEGREES          
REMARK 500    TYR O  27   CB  -  CG  -  CD1 ANGL. DEV. =   4.5 DEGREES          
REMARK 500    TYR P  23   CB  -  CG  -  CD2 ANGL. DEV. =  -4.2 DEGREES          
REMARK 500    TYR P  23   CB  -  CG  -  CD1 ANGL. DEV. =   3.8 DEGREES          
REMARK 500    TYR P 120   CB  -  CG  -  CD2 ANGL. DEV. =  -4.7 DEGREES          
REMARK 500    TYR P 120   CB  -  CG  -  CD1 ANGL. DEV. =   4.3 DEGREES          
REMARK 500    PRO P 143   C   -  N   -  CD  ANGL. DEV. = -19.5 DEGREES          
REMARK 500    SER Q 153   N   -  CA  -  C   ANGL. DEV. = -21.7 DEGREES          
REMARK 500    TYR R  21   CB  -  CG  -  CD2 ANGL. DEV. =  -3.9 DEGREES          
REMARK 500    MET S  59   CG  -  SD  -  CE  ANGL. DEV. = -11.0 DEGREES          
REMARK 500    GLY S 124   N   -  CA  -  C   ANGL. DEV. = -16.3 DEGREES          
REMARK 500    GLY T  17   N   -  CA  -  C   ANGL. DEV. =  38.5 DEGREES          
REMARK 500    PHE T 179   CB  -  CG  -  CD1 ANGL. DEV. =   4.7 DEGREES          
REMARK 500    TYR T 224   CB  -  CG  -  CD2 ANGL. DEV. =  -4.2 DEGREES          
REMARK 500    TYR T 224   CB  -  CG  -  CD1 ANGL. DEV. =   4.0 DEGREES          
REMARK 500    TYR U  25   CB  -  CG  -  CD2 ANGL. DEV. =  -4.6 DEGREES          
REMARK 500    GLN V   7   CB  -  CA  -  C   ANGL. DEV. = -13.6 DEGREES          
REMARK 500    GLY V  47   N   -  CA  -  C   ANGL. DEV. = -23.2 DEGREES          
REMARK 500    TYR V  61   CB  -  CG  -  CD2 ANGL. DEV. =  -3.7 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      62 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ALA B  40      -11.42    130.49                                   
REMARK 500    LYS B  52      -61.78     71.11                                   
REMARK 500    ILE B  54        2.82     81.18                                   
REMARK 500    GLU B 140      -74.05     68.03                                   
REMARK 500    GLU B 179     -119.20     61.48                                   
REMARK 500    ASN B 213     -136.56     49.36                                   
REMARK 500    ALA B 215       30.96   -150.36                                   
REMARK 500    ARG C   8      -62.79     77.67                                   
REMARK 500    THR C   9        8.57     58.52                                   
REMARK 500    PRO C 152       48.23    -85.36                                   
REMARK 500    ARG E  53       10.32     83.40                                   
REMARK 500    ASN E 104      -13.33     76.19                                   
REMARK 500    SER E 188     -133.54     58.35                                   
REMARK 500    MET E 189      154.56    137.56                                   
REMARK 500    PHE H   8      152.45    111.92                                   
REMARK 500    ASP H   9     -127.25     54.68                                   
REMARK 500    ASN H  28      149.61     92.02                                   
REMARK 500    ALA H  56      -61.07     72.88                                   
REMARK 500    ILE I  34       74.68   -101.25                                   
REMARK 500    ASP I 145        5.47     90.64                                   
REMARK 500    SER I 171      179.11     83.66                                   
REMARK 500    GLN J  30     -120.58     58.54                                   
REMARK 500    LYS J 114       -8.04     72.63                                   
REMARK 500    ASP K  11       31.45   -145.39                                   
REMARK 500    ASN K  24     -164.24     74.68                                   
REMARK 500    LYS K  41       42.06   -146.92                                   
REMARK 500    ALA K  50     -160.17     74.68                                   
REMARK 500    ALA K 122       81.55    108.79                                   
REMARK 500    ILE K 151     -173.37    174.29                                   
REMARK 500    PRO M 165       36.46    -95.12                                   
REMARK 500    ASP M 191     -133.14     48.60                                   
REMARK 500    MET N   5     -158.76    -95.01                                   
REMARK 500    SER N  10       12.75     87.03                                   
REMARK 500    VAL N  14      146.49   -171.53                                   
REMARK 500    ALA N  34       78.63   -102.02                                   
REMARK 500    ARG N  37       49.53    -86.56                                   
REMARK 500    ASN N  38       13.72   -147.40                                   
REMARK 500    PRO N 105     -172.58    -69.17                                   
REMARK 500    TYR N 141       -4.90     84.24                                   
REMARK 500    ALA P  40      -11.44    130.50                                   
REMARK 500    LYS P  52      -61.73     71.08                                   
REMARK 500    ILE P  54        2.82     81.18                                   
REMARK 500    GLU P 140      -74.04     68.00                                   
REMARK 500    GLU P 179     -119.24     61.48                                   
REMARK 500    ASN P 213     -136.55     49.38                                   
REMARK 500    ALA P 215       30.96   -150.42                                   
REMARK 500    ARG Q   8      -62.79     77.67                                   
REMARK 500    THR Q   9        8.57     58.52                                   
REMARK 500    PRO Q 152       48.20    -85.32                                   
REMARK 500    ARG S  53       10.32     83.38                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      78 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ASP E  147     GLU E  148                 -145.26                    
REMARK 500 MET G  181     LYS G  182                 -149.86                    
REMARK 500 LYS J   16     ASN J   17                 -146.76                    
REMARK 500 GLU M   18     ASP M   19                 -137.66                    
REMARK 500 ASP S  147     GLU S  148                 -145.24                    
REMARK 500 MET U  181     LYS U  182                 -149.87                    
REMARK 500 LYS X   16     ASN X   17                 -146.72                    
REMARK 500 GLU a   18     ASP a   19                 -137.66                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    ARG A  95         0.08    SIDE CHAIN                              
REMARK 500    TYR I 111         0.06    SIDE CHAIN                              
REMARK 500    ARG K 153         0.08    SIDE CHAIN                              
REMARK 500    TYR M 188         0.07    SIDE CHAIN                              
REMARK 500    ARG O  95         0.08    SIDE CHAIN                              
REMARK 500    TYR W 111         0.06    SIDE CHAIN                              
REMARK 500    ARG Y 153         0.08    SIDE CHAIN                              
REMARK 500    TYR a 188         0.07    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    THR I   1        -11.43                                           
REMARK 500    THR W   1        -11.45                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 610                                                                      
REMARK 610 MISSING HETEROATOM                                                   
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 610 I=INSERTION CODE):                                                   
REMARK 610   M RES C SSEQI                                                      
REMARK 610     KNM H  300                                                       
REMARK 610     KNM I  300                                                       
REMARK 610     KNM L  300                                                       
REMARK 610     KNM V  300                                                       
REMARK 610     KNM W  300                                                       
REMARK 610     KNM Z  300                                                       
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: Binding site for Ligand KNM H 300 bound to THR H   
REMARK 800  1                                                                   
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: Binding site for Ligand KNM I 300 bound to THR I   
REMARK 800  1                                                                   
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: Binding site for Ligand KNM L 300 bound to THR L   
REMARK 800  1                                                                   
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: Binding site for Ligand KNM V 300 bound to THR V   
REMARK 800  1                                                                   
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: Binding site for Ligand KNM W 300 bound to THR W   
REMARK 800  1                                                                   
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: Binding site for Ligand KNM Z 300 bound to THR Z   
REMARK 800  1                                                                   
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-2981   RELATED DB: EMDB                              
DBREF  5A0Q A    1   246  UNP    P60900   PSA6_HUMAN       1    246             
DBREF  5A0Q B    0   233  UNP    P25787   PSA2_HUMAN       1    234             
DBREF  5A0Q C    1   261  UNP    P25789   PSA4_HUMAN       1    261             
DBREF  5A0Q D    1   248  UNP    O14818   PSA7_HUMAN       1    248             
DBREF  5A0Q E    1   241  UNP    P28066   PSA5_HUMAN       1    241             
DBREF  5A0Q F    1   263  UNP    P25786   PSA1_HUMAN       1    263             
DBREF  5A0Q G    0   254  UNP    P25788   PSA3_HUMAN       1    255             
DBREF  5A0Q H    1   205  UNP    P28072   PSB6_HUMAN      35    239             
DBREF  5A0Q I    1   234  UNP    Q99436   PSB7_HUMAN      44    277             
DBREF  5A0Q J    1   204  UNP    P49720   PSB3_HUMAN       2    205             
DBREF  5A0Q K    1   201  UNP    P49721   PSB2_HUMAN       1    201             
DBREF  5A0Q L    1   204  UNP    P28074   PSB5_HUMAN      60    263             
DBREF  5A0Q M    1   213  UNP    P20618   PSB1_HUMAN      29    241             
DBREF  5A0Q N    1   219  UNP    P28070   PSB4_HUMAN      46    264             
DBREF  5A0Q O    1   246  UNP    P60900   PSA6_HUMAN       1    246             
DBREF  5A0Q P    0   233  UNP    P25787   PSA2_HUMAN       1    234             
DBREF  5A0Q Q    1   261  UNP    P25789   PSA4_HUMAN       1    261             
DBREF  5A0Q R    1   248  UNP    O14818   PSA7_HUMAN       1    248             
DBREF  5A0Q S    1   241  UNP    P28066   PSA5_HUMAN       1    241             
DBREF  5A0Q T    1   263  UNP    P25786   PSA1_HUMAN       1    263             
DBREF  5A0Q U    0   254  UNP    P25788   PSA3_HUMAN       1    255             
DBREF  5A0Q V    1   205  UNP    P28072   PSB6_HUMAN      35    239             
DBREF  5A0Q W    1   234  UNP    Q99436   PSB7_HUMAN      44    277             
DBREF  5A0Q X    1   204  UNP    P49720   PSB3_HUMAN       2    205             
DBREF  5A0Q Y    1   201  UNP    P49721   PSB2_HUMAN       1    201             
DBREF  5A0Q Z    1   204  UNP    P28074   PSB5_HUMAN      60    263             
DBREF  5A0Q a    1   213  UNP    P20618   PSB1_HUMAN      29    241             
DBREF  5A0Q b    1   219  UNP    P28070   PSB4_HUMAN      46    264             
SEQRES   1 A  246  MET SER ARG GLY SER SER ALA GLY PHE ASP ARG HIS ILE          
SEQRES   2 A  246  THR ILE PHE SER PRO GLU GLY ARG LEU TYR GLN VAL GLU          
SEQRES   3 A  246  TYR ALA PHE LYS ALA ILE ASN GLN GLY GLY LEU THR SER          
SEQRES   4 A  246  VAL ALA VAL ARG GLY LYS ASP CYS ALA VAL ILE VAL THR          
SEQRES   5 A  246  GLN LYS LYS VAL PRO ASP LYS LEU LEU ASP SER SER THR          
SEQRES   6 A  246  VAL THR HIS LEU PHE LYS ILE THR GLU ASN ILE GLY CYS          
SEQRES   7 A  246  VAL MET THR GLY MET THR ALA ASP SER ARG SER GLN VAL          
SEQRES   8 A  246  GLN ARG ALA ARG TYR GLU ALA ALA ASN TRP LYS TYR LYS          
SEQRES   9 A  246  TYR GLY TYR GLU ILE PRO VAL ASP MET LEU CYS LYS ARG          
SEQRES  10 A  246  ILE ALA ASP ILE SER GLN VAL TYR THR GLN ASN ALA GLU          
SEQRES  11 A  246  MET ARG PRO LEU GLY CYS CYS MET ILE LEU ILE GLY ILE          
SEQRES  12 A  246  ASP GLU GLU GLN GLY PRO GLN VAL TYR LYS CYS ASP PRO          
SEQRES  13 A  246  ALA GLY TYR TYR CYS GLY PHE LYS ALA THR ALA ALA GLY          
SEQRES  14 A  246  VAL LYS GLN THR GLU SER THR SER PHE LEU GLU LYS LYS          
SEQRES  15 A  246  VAL LYS LYS LYS PHE ASP TRP THR PHE GLU GLN THR VAL          
SEQRES  16 A  246  GLU THR ALA ILE THR CYS LEU SER THR VAL LEU SER ILE          
SEQRES  17 A  246  ASP PHE LYS PRO SER GLU ILE GLU VAL GLY VAL VAL THR          
SEQRES  18 A  246  VAL GLU ASN PRO LYS PHE ARG ILE LEU THR GLU ALA GLU          
SEQRES  19 A  246  ILE ASP ALA HIS LEU VAL ALA LEU ALA GLU ARG ASP              
SEQRES   1 B  234  MET ALA GLU ARG GLY TYR SER PHE SER LEU THR THR PHE          
SEQRES   2 B  234  SER PRO SER GLY LYS LEU VAL GLN ILE GLU TYR ALA LEU          
SEQRES   3 B  234  ALA ALA VAL ALA GLY GLY ALA PRO SER VAL GLY ILE LYS          
SEQRES   4 B  234  ALA ALA ASN GLY VAL VAL LEU ALA THR GLU LYS LYS GLN          
SEQRES   5 B  234  LYS SER ILE LEU TYR ASP GLU ARG SER VAL HIS LYS VAL          
SEQRES   6 B  234  GLU PRO ILE THR LYS HIS ILE GLY LEU VAL TYR SER GLY          
SEQRES   7 B  234  MET GLY PRO ASP TYR ARG VAL LEU VAL HIS ARG ALA ARG          
SEQRES   8 B  234  LYS LEU ALA GLN GLN TYR TYR LEU VAL TYR GLN GLU PRO          
SEQRES   9 B  234  ILE PRO THR ALA GLN LEU VAL GLN ARG VAL ALA SER VAL          
SEQRES  10 B  234  MET GLN GLU TYR THR GLN SER GLY GLY VAL ARG PRO PHE          
SEQRES  11 B  234  GLY VAL SER LEU LEU ILE CYS GLY TRP ASN GLU GLY ARG          
SEQRES  12 B  234  PRO TYR LEU PHE GLN SER ASP PRO SER GLY ALA TYR PHE          
SEQRES  13 B  234  ALA TRP LYS ALA THR ALA MET GLY LYS ASN TYR VAL ASN          
SEQRES  14 B  234  GLY LYS THR PHE LEU GLU LYS ARG TYR ASN GLU ASP LEU          
SEQRES  15 B  234  GLU LEU GLU ASP ALA ILE HIS THR ALA ILE LEU THR LEU          
SEQRES  16 B  234  LYS GLU SER PHE GLU GLY GLN MET THR GLU ASP ASN ILE          
SEQRES  17 B  234  GLU VAL GLY ILE CYS ASN GLU ALA GLY PHE ARG ARG LEU          
SEQRES  18 B  234  THR PRO THR GLU VAL LYS ASP TYR LEU ALA ALA ILE ALA          
SEQRES   1 C  261  MET SER ARG ARG TYR ASP SER ARG THR THR ILE PHE SER          
SEQRES   2 C  261  PRO GLU GLY ARG LEU TYR GLN VAL GLU TYR ALA MET GLU          
SEQRES   3 C  261  ALA ILE GLY HIS ALA GLY THR CYS LEU GLY ILE LEU ALA          
SEQRES   4 C  261  ASN ASP GLY VAL LEU LEU ALA ALA GLU ARG ARG ASN ILE          
SEQRES   5 C  261  HIS LYS LEU LEU ASP GLU VAL PHE PHE SER GLU LYS ILE          
SEQRES   6 C  261  TYR LYS LEU ASN GLU ASP MET ALA CYS SER VAL ALA GLY          
SEQRES   7 C  261  ILE THR SER ASP ALA ASN VAL LEU THR ASN GLU LEU ARG          
SEQRES   8 C  261  LEU ILE ALA GLN ARG TYR LEU LEU GLN TYR GLN GLU PRO          
SEQRES   9 C  261  ILE PRO CYS GLU GLN LEU VAL THR ALA LEU CYS ASP ILE          
SEQRES  10 C  261  LYS GLN ALA TYR THR GLN PHE GLY GLY LYS ARG PRO PHE          
SEQRES  11 C  261  GLY VAL SER LEU LEU TYR ILE GLY TRP ASP LYS HIS TYR          
SEQRES  12 C  261  GLY PHE GLN LEU TYR GLN SER ASP PRO SER GLY ASN TYR          
SEQRES  13 C  261  GLY GLY TRP LYS ALA THR CYS ILE GLY ASN ASN SER ALA          
SEQRES  14 C  261  ALA ALA VAL SER MET LEU LYS GLN ASP TYR LYS GLU GLY          
SEQRES  15 C  261  GLU MET THR LEU LYS SER ALA LEU ALA LEU ALA ILE LYS          
SEQRES  16 C  261  VAL LEU ASN LYS THR MET ASP VAL SER LYS LEU SER ALA          
SEQRES  17 C  261  GLU LYS VAL GLU ILE ALA THR LEU THR ARG GLU ASN GLY          
SEQRES  18 C  261  LYS THR VAL ILE ARG VAL LEU LYS GLN LYS GLU VAL GLU          
SEQRES  19 C  261  GLN LEU ILE LYS LYS HIS GLU GLU GLU GLU ALA LYS ALA          
SEQRES  20 C  261  GLU ARG GLU LYS LYS GLU LYS GLU GLN LYS GLU LYS ASP          
SEQRES  21 C  261  LYS                                                          
SEQRES   1 D  248  MET SER TYR ASP ARG ALA ILE THR VAL PHE SER PRO ASP          
SEQRES   2 D  248  GLY HIS LEU PHE GLN VAL GLU TYR ALA GLN GLU ALA VAL          
SEQRES   3 D  248  LYS LYS GLY SER THR ALA VAL GLY VAL ARG GLY ARG ASP          
SEQRES   4 D  248  ILE VAL VAL LEU GLY VAL GLU LYS LYS SER VAL ALA LYS          
SEQRES   5 D  248  LEU GLN ASP GLU ARG THR VAL ARG LYS ILE CYS ALA LEU          
SEQRES   6 D  248  ASP ASP ASN VAL CYS MET ALA PHE ALA GLY LEU THR ALA          
SEQRES   7 D  248  ASP ALA ARG ILE VAL ILE ASN ARG ALA ARG VAL GLU CYS          
SEQRES   8 D  248  GLN SER HIS ARG LEU THR VAL GLU ASP PRO VAL THR VAL          
SEQRES   9 D  248  GLU TYR ILE THR ARG TYR ILE ALA SER LEU LYS GLN ARG          
SEQRES  10 D  248  TYR THR GLN SER ASN GLY ARG ARG PRO PHE GLY ILE SER          
SEQRES  11 D  248  ALA LEU ILE VAL GLY PHE ASP PHE ASP GLY THR PRO ARG          
SEQRES  12 D  248  LEU TYR GLN THR ASP PRO SER GLY THR TYR HIS ALA TRP          
SEQRES  13 D  248  LYS ALA ASN ALA ILE GLY ARG GLY ALA LYS SER VAL ARG          
SEQRES  14 D  248  GLU PHE LEU GLU LYS ASN TYR THR ASP GLU ALA ILE GLU          
SEQRES  15 D  248  THR ASP ASP LEU THR ILE LYS LEU VAL ILE LYS ALA LEU          
SEQRES  16 D  248  LEU GLU VAL VAL GLN SER GLY GLY LYS ASN ILE GLU LEU          
SEQRES  17 D  248  ALA VAL MET ARG ARG ASP GLN SER LEU LYS ILE LEU ASN          
SEQRES  18 D  248  PRO GLU GLU ILE GLU LYS TYR VAL ALA GLU ILE GLU LYS          
SEQRES  19 D  248  GLU LYS GLU GLU ASN GLU LYS LYS LYS GLN LYS LYS ALA          
SEQRES  20 D  248  SER                                                          
SEQRES   1 E  241  MET PHE LEU THR ARG SER GLU TYR ASP ARG GLY VAL ASN          
SEQRES   2 E  241  THR PHE SER PRO GLU GLY ARG LEU PHE GLN VAL GLU TYR          
SEQRES   3 E  241  ALA ILE GLU ALA ILE LYS LEU GLY SER THR ALA ILE GLY          
SEQRES   4 E  241  ILE GLN THR SER GLU GLY VAL CYS LEU ALA VAL GLU LYS          
SEQRES   5 E  241  ARG ILE THR SER PRO LEU MET GLU PRO SER SER ILE GLU          
SEQRES   6 E  241  LYS ILE VAL GLU ILE ASP ALA HIS ILE GLY CYS ALA MET          
SEQRES   7 E  241  SER GLY LEU ILE ALA ASP ALA LYS THR LEU ILE ASP LYS          
SEQRES   8 E  241  ALA ARG VAL GLU THR GLN ASN HIS TRP PHE THR TYR ASN          
SEQRES   9 E  241  GLU THR MET THR VAL GLU SER VAL THR GLN ALA VAL SER          
SEQRES  10 E  241  ASN LEU ALA LEU GLN PHE GLY GLU GLU ASP ALA ASP PRO          
SEQRES  11 E  241  GLY ALA MET SER ARG PRO PHE GLY VAL ALA LEU LEU PHE          
SEQRES  12 E  241  GLY GLY VAL ASP GLU LYS GLY PRO GLN LEU PHE HIS MET          
SEQRES  13 E  241  ASP PRO SER GLY THR PHE VAL GLN CYS ASP ALA ARG ALA          
SEQRES  14 E  241  ILE GLY SER ALA SER GLU GLY ALA GLN SER SER LEU GLN          
SEQRES  15 E  241  GLU VAL TYR HIS LYS SER MET THR LEU LYS GLU ALA ILE          
SEQRES  16 E  241  LYS SER SER LEU ILE ILE LEU LYS GLN VAL MET GLU GLU          
SEQRES  17 E  241  LYS LEU ASN ALA THR ASN ILE GLU LEU ALA THR VAL GLN          
SEQRES  18 E  241  PRO GLY GLN ASN PHE HIS MET PHE THR LYS GLU GLU LEU          
SEQRES  19 E  241  GLU GLU VAL ILE LYS ASP ILE                                  
SEQRES   1 F  263  MET PHE ARG ASN GLN TYR ASP ASN ASP VAL THR VAL TRP          
SEQRES   2 F  263  SER PRO GLN GLY ARG ILE HIS GLN ILE GLU TYR ALA MET          
SEQRES   3 F  263  GLU ALA VAL LYS GLN GLY SER ALA THR VAL GLY LEU LYS          
SEQRES   4 F  263  SER LYS THR HIS ALA VAL LEU VAL ALA LEU LYS ARG ALA          
SEQRES   5 F  263  GLN SER GLU LEU ALA ALA HIS GLN LYS LYS ILE LEU HIS          
SEQRES   6 F  263  VAL ASP ASN HIS ILE GLY ILE SER ILE ALA GLY LEU THR          
SEQRES   7 F  263  ALA ASP ALA ARG LEU LEU CYS ASN PHE MET ARG GLN GLU          
SEQRES   8 F  263  CYS LEU ASP SER ARG PHE VAL PHE ASP ARG PRO LEU PRO          
SEQRES   9 F  263  VAL SER ARG LEU VAL SER LEU ILE GLY SER LYS THR GLN          
SEQRES  10 F  263  ILE PRO THR GLN ARG TYR GLY ARG ARG PRO TYR GLY VAL          
SEQRES  11 F  263  GLY LEU LEU ILE ALA GLY TYR ASP ASP MET GLY PRO HIS          
SEQRES  12 F  263  ILE PHE GLN THR CYS PRO SER ALA ASN TYR PHE ASP CYS          
SEQRES  13 F  263  ARG ALA MET SER ILE GLY ALA ARG SER GLN SER ALA ARG          
SEQRES  14 F  263  THR TYR LEU GLU ARG HIS MET SER GLU PHE MET GLU CYS          
SEQRES  15 F  263  ASN LEU ASN GLU LEU VAL LYS HIS GLY LEU ARG ALA LEU          
SEQRES  16 F  263  ARG GLU THR LEU PRO ALA GLU GLN ASP LEU THR THR LYS          
SEQRES  17 F  263  ASN VAL SER ILE GLY ILE VAL GLY LYS ASP LEU GLU PHE          
SEQRES  18 F  263  THR ILE TYR ASP ASP ASP ASP VAL SER PRO PHE LEU GLU          
SEQRES  19 F  263  GLY LEU GLU GLU ARG PRO GLN ARG LYS ALA GLN PRO ALA          
SEQRES  20 F  263  GLN PRO ALA ASP GLU PRO ALA GLU LYS ALA ASP GLU PRO          
SEQRES  21 F  263  MET GLU HIS                                                  
SEQRES   1 G  255  MET SER SER ILE GLY THR GLY TYR ASP LEU SER ALA SER          
SEQRES   2 G  255  THR PHE SER PRO ASP GLY ARG VAL PHE GLN VAL GLU TYR          
SEQRES   3 G  255  ALA MET LYS ALA VAL GLU ASN SER SER THR ALA ILE GLY          
SEQRES   4 G  255  ILE ARG CYS LYS ASP GLY VAL VAL PHE GLY VAL GLU LYS          
SEQRES   5 G  255  LEU VAL LEU SER LYS LEU TYR GLU GLU GLY SER ASN LYS          
SEQRES   6 G  255  ARG LEU PHE ASN VAL ASP ARG HIS VAL GLY MET ALA VAL          
SEQRES   7 G  255  ALA GLY LEU LEU ALA ASP ALA ARG SER LEU ALA ASP ILE          
SEQRES   8 G  255  ALA ARG GLU GLU ALA SER ASN PHE ARG SER ASN PHE GLY          
SEQRES   9 G  255  TYR ASN ILE PRO LEU LYS HIS LEU ALA ASP ARG VAL ALA          
SEQRES  10 G  255  MET TYR VAL HIS ALA TYR THR LEU TYR SER ALA VAL ARG          
SEQRES  11 G  255  PRO PHE GLY CYS SER PHE MET LEU GLY SER TYR SER VAL          
SEQRES  12 G  255  ASN ASP GLY ALA GLN LEU TYR MET ILE ASP PRO SER GLY          
SEQRES  13 G  255  VAL SER TYR GLY TYR TRP GLY CYS ALA ILE GLY LYS ALA          
SEQRES  14 G  255  ARG GLN ALA ALA LYS THR GLU ILE GLU LYS LEU GLN MET          
SEQRES  15 G  255  LYS GLU MET THR CYS ARG ASP ILE VAL LYS GLU VAL ALA          
SEQRES  16 G  255  LYS ILE ILE TYR ILE VAL HIS ASP GLU VAL LYS ASP LYS          
SEQRES  17 G  255  ALA PHE GLU LEU GLU LEU SER TRP VAL GLY GLU LEU THR          
SEQRES  18 G  255  ASN GLY ARG HIS GLU ILE VAL PRO LYS ASP ILE ARG GLU          
SEQRES  19 G  255  GLU ALA GLU LYS TYR ALA LYS GLU SER LEU LYS GLU GLU          
SEQRES  20 G  255  ASP GLU SER ASP ASP ASP ASN MET                              
SEQRES   1 H  205  THR THR ILE MET ALA VAL GLN PHE ASP GLY GLY VAL VAL          
SEQRES   2 H  205  LEU GLY ALA ASP SER ARG THR THR THR GLY SER TYR ILE          
SEQRES   3 H  205  ALA ASN ARG VAL THR ASP LYS LEU THR PRO ILE HIS ASP          
SEQRES   4 H  205  ARG ILE PHE CYS CYS ARG SER GLY SER ALA ALA ASP THR          
SEQRES   5 H  205  GLN ALA VAL ALA ASP ALA VAL THR TYR GLN LEU GLY PHE          
SEQRES   6 H  205  HIS SER ILE GLU LEU ASN GLU PRO PRO LEU VAL HIS THR          
SEQRES   7 H  205  ALA ALA SER LEU PHE LYS GLU MET CYS TYR ARG TYR ARG          
SEQRES   8 H  205  GLU ASP LEU MET ALA GLY ILE ILE ILE ALA GLY TRP ASP          
SEQRES   9 H  205  PRO GLN GLU GLY GLY GLN VAL TYR SER VAL PRO MET GLY          
SEQRES  10 H  205  GLY MET MET VAL ARG GLN SER PHE ALA ILE GLY GLY SER          
SEQRES  11 H  205  GLY SER SER TYR ILE TYR GLY TYR VAL ASP ALA THR TYR          
SEQRES  12 H  205  ARG GLU GLY MET THR LYS GLU GLU CYS LEU GLN PHE THR          
SEQRES  13 H  205  ALA ASN ALA LEU ALA LEU ALA MET GLU ARG ASP GLY SER          
SEQRES  14 H  205  SER GLY GLY VAL ILE ARG LEU ALA ALA ILE ALA GLU SER          
SEQRES  15 H  205  GLY VAL GLU ARG GLN VAL LEU LEU GLY ASP GLN ILE PRO          
SEQRES  16 H  205  LYS PHE ALA VAL ALA THR LEU PRO PRO ALA                      
SEQRES   1 I  234  THR THR ILE ALA GLY VAL VAL TYR LYS ASP GLY ILE VAL          
SEQRES   2 I  234  LEU GLY ALA ASP THR ARG ALA THR GLU GLY MET VAL VAL          
SEQRES   3 I  234  ALA ASP LYS ASN CYS SER LYS ILE HIS PHE ILE SER PRO          
SEQRES   4 I  234  ASN ILE TYR CYS CYS GLY ALA GLY THR ALA ALA ASP THR          
SEQRES   5 I  234  ASP MET THR THR GLN LEU ILE SER SER ASN LEU GLU LEU          
SEQRES   6 I  234  HIS SER LEU SER THR GLY ARG LEU PRO ARG VAL VAL THR          
SEQRES   7 I  234  ALA ASN ARG MET LEU LYS GLN MET LEU PHE ARG TYR GLN          
SEQRES   8 I  234  GLY TYR ILE GLY ALA ALA LEU VAL LEU GLY GLY VAL ASP          
SEQRES   9 I  234  VAL THR GLY PRO HIS LEU TYR SER ILE TYR PRO HIS GLY          
SEQRES  10 I  234  SER THR ASP LYS LEU PRO TYR VAL THR MET GLY SER GLY          
SEQRES  11 I  234  SER LEU ALA ALA MET ALA VAL PHE GLU ASP LYS PHE ARG          
SEQRES  12 I  234  PRO ASP MET GLU GLU GLU GLU ALA LYS ASN LEU VAL SER          
SEQRES  13 I  234  GLU ALA ILE ALA ALA GLY ILE PHE ASN ASP LEU GLY SER          
SEQRES  14 I  234  GLY SER ASN ILE ASP LEU CYS VAL ILE SER LYS ASN LYS          
SEQRES  15 I  234  LEU ASP PHE LEU ARG PRO TYR THR VAL PRO ASN LYS LYS          
SEQRES  16 I  234  GLY THR ARG LEU GLY ARG TYR ARG CYS GLU LYS GLY THR          
SEQRES  17 I  234  THR ALA VAL LEU THR GLU LYS ILE THR PRO LEU GLU ILE          
SEQRES  18 I  234  GLU VAL LEU GLU GLU THR VAL GLN THR MET ASP THR SER          
SEQRES   1 J  204  SER ILE MET SER TYR ASN GLY GLY ALA VAL MET ALA MET          
SEQRES   2 J  204  LYS GLY LYS ASN CYS VAL ALA ILE ALA ALA ASP ARG ARG          
SEQRES   3 J  204  PHE GLY ILE GLN ALA GLN MET VAL THR THR ASP PHE GLN          
SEQRES   4 J  204  LYS ILE PHE PRO MET GLY ASP ARG LEU TYR ILE GLY LEU          
SEQRES   5 J  204  ALA GLY LEU ALA THR ASP VAL GLN THR VAL ALA GLN ARG          
SEQRES   6 J  204  LEU LYS PHE ARG LEU ASN LEU TYR GLU LEU LYS GLU GLY          
SEQRES   7 J  204  ARG GLN ILE LYS PRO TYR THR LEU MET SER MET VAL ALA          
SEQRES   8 J  204  ASN LEU LEU TYR GLU LYS ARG PHE GLY PRO TYR TYR THR          
SEQRES   9 J  204  GLU PRO VAL ILE ALA GLY LEU ASP PRO LYS THR PHE LYS          
SEQRES  10 J  204  PRO PHE ILE CYS SER LEU ASP LEU ILE GLY CYS PRO MET          
SEQRES  11 J  204  VAL THR ASP ASP PHE VAL VAL SER GLY THR CYS ALA GLU          
SEQRES  12 J  204  GLN MET TYR GLY MET CYS GLU SER LEU TRP GLU PRO ASN          
SEQRES  13 J  204  MET ASP PRO ASP HIS LEU PHE GLU THR ILE SER GLN ALA          
SEQRES  14 J  204  MET LEU ASN ALA VAL ASP ARG ASP ALA VAL SER GLY MET          
SEQRES  15 J  204  GLY VAL ILE VAL HIS ILE ILE GLU LYS ASP LYS ILE THR          
SEQRES  16 J  204  THR ARG THR LEU LYS ALA ARG MET ASP                          
SEQRES   1 K  201  MET GLU TYR LEU ILE GLY ILE GLN GLY PRO ASP TYR VAL          
SEQRES   2 K  201  LEU VAL ALA SER ASP ARG VAL ALA ALA SER ASN ILE VAL          
SEQRES   3 K  201  GLN MET LYS ASP ASP HIS ASP LYS MET PHE LYS MET SER          
SEQRES   4 K  201  GLU LYS ILE LEU LEU LEU CYS VAL GLY GLU ALA GLY ASP          
SEQRES   5 K  201  THR VAL GLN PHE ALA GLU TYR ILE GLN LYS ASN VAL GLN          
SEQRES   6 K  201  LEU TYR LYS MET ARG ASN GLY TYR GLU LEU SER PRO THR          
SEQRES   7 K  201  ALA ALA ALA ASN PHE THR ARG ARG ASN LEU ALA ASP CYS          
SEQRES   8 K  201  LEU ARG SER ARG THR PRO TYR HIS VAL ASN LEU LEU LEU          
SEQRES   9 K  201  ALA GLY TYR ASP GLU HIS GLU GLY PRO ALA LEU TYR TYR          
SEQRES  10 K  201  MET ASP TYR LEU ALA ALA LEU ALA LYS ALA PRO PHE ALA          
SEQRES  11 K  201  ALA HIS GLY TYR GLY ALA PHE LEU THR LEU SER ILE LEU          
SEQRES  12 K  201  ASP ARG TYR TYR THR PRO THR ILE SER ARG GLU ARG ALA          
SEQRES  13 K  201  VAL GLU LEU LEU ARG LYS CYS LEU GLU GLU LEU GLN LYS          
SEQRES  14 K  201  ARG PHE ILE LEU ASN LEU PRO THR PHE SER VAL ARG ILE          
SEQRES  15 K  201  ILE ASP LYS ASN GLY ILE HIS ASP LEU ASP ASN ILE SER          
SEQRES  16 K  201  PHE PRO LYS GLN GLY SER                                      
SEQRES   1 L  204  THR THR THR LEU ALA PHE LYS PHE ARG HIS GLY VAL ILE          
SEQRES   2 L  204  VAL ALA ALA ASP SER ARG ALA THR ALA GLY ALA TYR ILE          
SEQRES   3 L  204  ALA SER GLN THR VAL LYS LYS VAL ILE GLU ILE ASN PRO          
SEQRES   4 L  204  TYR LEU LEU GLY THR MET ALA GLY GLY ALA ALA ASP CYS          
SEQRES   5 L  204  SER PHE TRP GLU ARG LEU LEU ALA ARG GLN CYS ARG ILE          
SEQRES   6 L  204  TYR GLU LEU ARG ASN LYS GLU ARG ILE SER VAL ALA ALA          
SEQRES   7 L  204  ALA SER LYS LEU LEU ALA ASN MET VAL TYR GLN TYR LYS          
SEQRES   8 L  204  GLY MET GLY LEU SER MET GLY THR MET ILE CYS GLY TRP          
SEQRES   9 L  204  ASP LYS ARG GLY PRO GLY LEU TYR TYR VAL ASP SER GLU          
SEQRES  10 L  204  GLY ASN ARG ILE SER GLY ALA THR PHE SER VAL GLY SER          
SEQRES  11 L  204  GLY SER VAL TYR ALA TYR GLY VAL MET ASP ARG GLY TYR          
SEQRES  12 L  204  SER TYR ASP LEU GLU VAL GLU GLN ALA TYR ASP LEU ALA          
SEQRES  13 L  204  ARG ARG ALA ILE TYR GLN ALA THR TYR ARG ASP ALA TYR          
SEQRES  14 L  204  SER GLY GLY ALA VAL ASN LEU TYR HIS VAL ARG GLU ASP          
SEQRES  15 L  204  GLY TRP ILE ARG VAL SER SER ASP ASN VAL ALA ASP LEU          
SEQRES  16 L  204  HIS GLU LYS TYR SER GLY SER THR PRO                          
SEQRES   1 M  213  ARG PHE SER PRO TYR VAL PHE ASN GLY GLY THR ILE LEU          
SEQRES   2 M  213  ALA ILE ALA GLY GLU ASP PHE ALA ILE VAL ALA SER ASP          
SEQRES   3 M  213  THR ARG LEU SER GLU GLY PHE SER ILE HIS THR ARG ASP          
SEQRES   4 M  213  SER PRO LYS CYS TYR LYS LEU THR ASP LYS THR VAL ILE          
SEQRES   5 M  213  GLY CYS SER GLY PHE HIS GLY ASP CYS LEU THR LEU THR          
SEQRES   6 M  213  LYS ILE ILE GLU ALA ARG LEU LYS MET TYR LYS HIS SER          
SEQRES   7 M  213  ASN ASN LYS ALA MET THR THR GLY ALA ILE ALA ALA MET          
SEQRES   8 M  213  LEU SER THR ILE LEU TYR SER ARG ARG PHE PHE PRO TYR          
SEQRES   9 M  213  TYR VAL TYR ASN ILE ILE GLY GLY LEU ASP GLU GLU GLY          
SEQRES  10 M  213  LYS GLY ALA VAL TYR SER PHE ASP PRO VAL GLY SER TYR          
SEQRES  11 M  213  GLN ARG ASP SER PHE LYS ALA GLY GLY SER ALA SER ALA          
SEQRES  12 M  213  MET LEU GLN PRO LEU LEU ASP ASN GLN VAL GLY PHE LYS          
SEQRES  13 M  213  ASN MET GLN ASN VAL GLU HIS VAL PRO LEU SER LEU ASP          
SEQRES  14 M  213  ARG ALA MET ARG LEU VAL LYS ASP VAL PHE ILE SER ALA          
SEQRES  15 M  213  ALA GLU ARG ASP VAL TYR THR GLY ASP ALA LEU ARG ILE          
SEQRES  16 M  213  CYS ILE VAL THR LYS GLU GLY ILE ARG GLU GLU THR VAL          
SEQRES  17 M  213  SER LEU ARG LYS ASP                                          
SEQRES   1 N  219  THR GLN ASN PRO MET VAL THR GLY THR SER VAL LEU GLY          
SEQRES   2 N  219  VAL LYS PHE GLU GLY GLY VAL VAL ILE ALA ALA ASP MET          
SEQRES   3 N  219  LEU GLY SER TYR GLY SER LEU ALA ARG PHE ARG ASN ILE          
SEQRES   4 N  219  SER ARG ILE MET ARG VAL ASN ASN SER THR MET LEU GLY          
SEQRES   5 N  219  ALA SER GLY ASP TYR ALA ASP PHE GLN TYR LEU LYS GLN          
SEQRES   6 N  219  VAL LEU GLY GLN MET VAL ILE ASP GLU GLU LEU LEU GLY          
SEQRES   7 N  219  ASP GLY HIS SER TYR SER PRO ARG ALA ILE HIS SER TRP          
SEQRES   8 N  219  LEU THR ARG ALA MET TYR SER ARG ARG SER LYS MET ASN          
SEQRES   9 N  219  PRO LEU TRP ASN THR MET VAL ILE GLY GLY TYR ALA ASP          
SEQRES  10 N  219  GLY GLU SER PHE LEU GLY TYR VAL ASP MET LEU GLY VAL          
SEQRES  11 N  219  ALA TYR GLU ALA PRO SER LEU ALA THR GLY TYR GLY ALA          
SEQRES  12 N  219  TYR LEU ALA GLN PRO LEU LEU ARG GLU VAL LEU GLU LYS          
SEQRES  13 N  219  GLN PRO VAL LEU SER GLN THR GLU ALA ARG ASP LEU VAL          
SEQRES  14 N  219  GLU ARG CYS MET ARG VAL LEU TYR TYR ARG ASP ALA ARG          
SEQRES  15 N  219  SER TYR ASN ARG PHE GLN ILE ALA THR VAL THR GLU LYS          
SEQRES  16 N  219  GLY VAL GLU ILE GLU GLY PRO LEU SER THR GLU THR ASN          
SEQRES  17 N  219  TRP ASP ILE ALA HIS MET ILE SER GLY PHE GLU                  
SEQRES   1 O  246  MET SER ARG GLY SER SER ALA GLY PHE ASP ARG HIS ILE          
SEQRES   2 O  246  THR ILE PHE SER PRO GLU GLY ARG LEU TYR GLN VAL GLU          
SEQRES   3 O  246  TYR ALA PHE LYS ALA ILE ASN GLN GLY GLY LEU THR SER          
SEQRES   4 O  246  VAL ALA VAL ARG GLY LYS ASP CYS ALA VAL ILE VAL THR          
SEQRES   5 O  246  GLN LYS LYS VAL PRO ASP LYS LEU LEU ASP SER SER THR          
SEQRES   6 O  246  VAL THR HIS LEU PHE LYS ILE THR GLU ASN ILE GLY CYS          
SEQRES   7 O  246  VAL MET THR GLY MET THR ALA ASP SER ARG SER GLN VAL          
SEQRES   8 O  246  GLN ARG ALA ARG TYR GLU ALA ALA ASN TRP LYS TYR LYS          
SEQRES   9 O  246  TYR GLY TYR GLU ILE PRO VAL ASP MET LEU CYS LYS ARG          
SEQRES  10 O  246  ILE ALA ASP ILE SER GLN VAL TYR THR GLN ASN ALA GLU          
SEQRES  11 O  246  MET ARG PRO LEU GLY CYS CYS MET ILE LEU ILE GLY ILE          
SEQRES  12 O  246  ASP GLU GLU GLN GLY PRO GLN VAL TYR LYS CYS ASP PRO          
SEQRES  13 O  246  ALA GLY TYR TYR CYS GLY PHE LYS ALA THR ALA ALA GLY          
SEQRES  14 O  246  VAL LYS GLN THR GLU SER THR SER PHE LEU GLU LYS LYS          
SEQRES  15 O  246  VAL LYS LYS LYS PHE ASP TRP THR PHE GLU GLN THR VAL          
SEQRES  16 O  246  GLU THR ALA ILE THR CYS LEU SER THR VAL LEU SER ILE          
SEQRES  17 O  246  ASP PHE LYS PRO SER GLU ILE GLU VAL GLY VAL VAL THR          
SEQRES  18 O  246  VAL GLU ASN PRO LYS PHE ARG ILE LEU THR GLU ALA GLU          
SEQRES  19 O  246  ILE ASP ALA HIS LEU VAL ALA LEU ALA GLU ARG ASP              
SEQRES   1 P  234  MET ALA GLU ARG GLY TYR SER PHE SER LEU THR THR PHE          
SEQRES   2 P  234  SER PRO SER GLY LYS LEU VAL GLN ILE GLU TYR ALA LEU          
SEQRES   3 P  234  ALA ALA VAL ALA GLY GLY ALA PRO SER VAL GLY ILE LYS          
SEQRES   4 P  234  ALA ALA ASN GLY VAL VAL LEU ALA THR GLU LYS LYS GLN          
SEQRES   5 P  234  LYS SER ILE LEU TYR ASP GLU ARG SER VAL HIS LYS VAL          
SEQRES   6 P  234  GLU PRO ILE THR LYS HIS ILE GLY LEU VAL TYR SER GLY          
SEQRES   7 P  234  MET GLY PRO ASP TYR ARG VAL LEU VAL HIS ARG ALA ARG          
SEQRES   8 P  234  LYS LEU ALA GLN GLN TYR TYR LEU VAL TYR GLN GLU PRO          
SEQRES   9 P  234  ILE PRO THR ALA GLN LEU VAL GLN ARG VAL ALA SER VAL          
SEQRES  10 P  234  MET GLN GLU TYR THR GLN SER GLY GLY VAL ARG PRO PHE          
SEQRES  11 P  234  GLY VAL SER LEU LEU ILE CYS GLY TRP ASN GLU GLY ARG          
SEQRES  12 P  234  PRO TYR LEU PHE GLN SER ASP PRO SER GLY ALA TYR PHE          
SEQRES  13 P  234  ALA TRP LYS ALA THR ALA MET GLY LYS ASN TYR VAL ASN          
SEQRES  14 P  234  GLY LYS THR PHE LEU GLU LYS ARG TYR ASN GLU ASP LEU          
SEQRES  15 P  234  GLU LEU GLU ASP ALA ILE HIS THR ALA ILE LEU THR LEU          
SEQRES  16 P  234  LYS GLU SER PHE GLU GLY GLN MET THR GLU ASP ASN ILE          
SEQRES  17 P  234  GLU VAL GLY ILE CYS ASN GLU ALA GLY PHE ARG ARG LEU          
SEQRES  18 P  234  THR PRO THR GLU VAL LYS ASP TYR LEU ALA ALA ILE ALA          
SEQRES   1 Q  261  MET SER ARG ARG TYR ASP SER ARG THR THR ILE PHE SER          
SEQRES   2 Q  261  PRO GLU GLY ARG LEU TYR GLN VAL GLU TYR ALA MET GLU          
SEQRES   3 Q  261  ALA ILE GLY HIS ALA GLY THR CYS LEU GLY ILE LEU ALA          
SEQRES   4 Q  261  ASN ASP GLY VAL LEU LEU ALA ALA GLU ARG ARG ASN ILE          
SEQRES   5 Q  261  HIS LYS LEU LEU ASP GLU VAL PHE PHE SER GLU LYS ILE          
SEQRES   6 Q  261  TYR LYS LEU ASN GLU ASP MET ALA CYS SER VAL ALA GLY          
SEQRES   7 Q  261  ILE THR SER ASP ALA ASN VAL LEU THR ASN GLU LEU ARG          
SEQRES   8 Q  261  LEU ILE ALA GLN ARG TYR LEU LEU GLN TYR GLN GLU PRO          
SEQRES   9 Q  261  ILE PRO CYS GLU GLN LEU VAL THR ALA LEU CYS ASP ILE          
SEQRES  10 Q  261  LYS GLN ALA TYR THR GLN PHE GLY GLY LYS ARG PRO PHE          
SEQRES  11 Q  261  GLY VAL SER LEU LEU TYR ILE GLY TRP ASP LYS HIS TYR          
SEQRES  12 Q  261  GLY PHE GLN LEU TYR GLN SER ASP PRO SER GLY ASN TYR          
SEQRES  13 Q  261  GLY GLY TRP LYS ALA THR CYS ILE GLY ASN ASN SER ALA          
SEQRES  14 Q  261  ALA ALA VAL SER MET LEU LYS GLN ASP TYR LYS GLU GLY          
SEQRES  15 Q  261  GLU MET THR LEU LYS SER ALA LEU ALA LEU ALA ILE LYS          
SEQRES  16 Q  261  VAL LEU ASN LYS THR MET ASP VAL SER LYS LEU SER ALA          
SEQRES  17 Q  261  GLU LYS VAL GLU ILE ALA THR LEU THR ARG GLU ASN GLY          
SEQRES  18 Q  261  LYS THR VAL ILE ARG VAL LEU LYS GLN LYS GLU VAL GLU          
SEQRES  19 Q  261  GLN LEU ILE LYS LYS HIS GLU GLU GLU GLU ALA LYS ALA          
SEQRES  20 Q  261  GLU ARG GLU LYS LYS GLU LYS GLU GLN LYS GLU LYS ASP          
SEQRES  21 Q  261  LYS                                                          
SEQRES   1 R  248  MET SER TYR ASP ARG ALA ILE THR VAL PHE SER PRO ASP          
SEQRES   2 R  248  GLY HIS LEU PHE GLN VAL GLU TYR ALA GLN GLU ALA VAL          
SEQRES   3 R  248  LYS LYS GLY SER THR ALA VAL GLY VAL ARG GLY ARG ASP          
SEQRES   4 R  248  ILE VAL VAL LEU GLY VAL GLU LYS LYS SER VAL ALA LYS          
SEQRES   5 R  248  LEU GLN ASP GLU ARG THR VAL ARG LYS ILE CYS ALA LEU          
SEQRES   6 R  248  ASP ASP ASN VAL CYS MET ALA PHE ALA GLY LEU THR ALA          
SEQRES   7 R  248  ASP ALA ARG ILE VAL ILE ASN ARG ALA ARG VAL GLU CYS          
SEQRES   8 R  248  GLN SER HIS ARG LEU THR VAL GLU ASP PRO VAL THR VAL          
SEQRES   9 R  248  GLU TYR ILE THR ARG TYR ILE ALA SER LEU LYS GLN ARG          
SEQRES  10 R  248  TYR THR GLN SER ASN GLY ARG ARG PRO PHE GLY ILE SER          
SEQRES  11 R  248  ALA LEU ILE VAL GLY PHE ASP PHE ASP GLY THR PRO ARG          
SEQRES  12 R  248  LEU TYR GLN THR ASP PRO SER GLY THR TYR HIS ALA TRP          
SEQRES  13 R  248  LYS ALA ASN ALA ILE GLY ARG GLY ALA LYS SER VAL ARG          
SEQRES  14 R  248  GLU PHE LEU GLU LYS ASN TYR THR ASP GLU ALA ILE GLU          
SEQRES  15 R  248  THR ASP ASP LEU THR ILE LYS LEU VAL ILE LYS ALA LEU          
SEQRES  16 R  248  LEU GLU VAL VAL GLN SER GLY GLY LYS ASN ILE GLU LEU          
SEQRES  17 R  248  ALA VAL MET ARG ARG ASP GLN SER LEU LYS ILE LEU ASN          
SEQRES  18 R  248  PRO GLU GLU ILE GLU LYS TYR VAL ALA GLU ILE GLU LYS          
SEQRES  19 R  248  GLU LYS GLU GLU ASN GLU LYS LYS LYS GLN LYS LYS ALA          
SEQRES  20 R  248  SER                                                          
SEQRES   1 S  241  MET PHE LEU THR ARG SER GLU TYR ASP ARG GLY VAL ASN          
SEQRES   2 S  241  THR PHE SER PRO GLU GLY ARG LEU PHE GLN VAL GLU TYR          
SEQRES   3 S  241  ALA ILE GLU ALA ILE LYS LEU GLY SER THR ALA ILE GLY          
SEQRES   4 S  241  ILE GLN THR SER GLU GLY VAL CYS LEU ALA VAL GLU LYS          
SEQRES   5 S  241  ARG ILE THR SER PRO LEU MET GLU PRO SER SER ILE GLU          
SEQRES   6 S  241  LYS ILE VAL GLU ILE ASP ALA HIS ILE GLY CYS ALA MET          
SEQRES   7 S  241  SER GLY LEU ILE ALA ASP ALA LYS THR LEU ILE ASP LYS          
SEQRES   8 S  241  ALA ARG VAL GLU THR GLN ASN HIS TRP PHE THR TYR ASN          
SEQRES   9 S  241  GLU THR MET THR VAL GLU SER VAL THR GLN ALA VAL SER          
SEQRES  10 S  241  ASN LEU ALA LEU GLN PHE GLY GLU GLU ASP ALA ASP PRO          
SEQRES  11 S  241  GLY ALA MET SER ARG PRO PHE GLY VAL ALA LEU LEU PHE          
SEQRES  12 S  241  GLY GLY VAL ASP GLU LYS GLY PRO GLN LEU PHE HIS MET          
SEQRES  13 S  241  ASP PRO SER GLY THR PHE VAL GLN CYS ASP ALA ARG ALA          
SEQRES  14 S  241  ILE GLY SER ALA SER GLU GLY ALA GLN SER SER LEU GLN          
SEQRES  15 S  241  GLU VAL TYR HIS LYS SER MET THR LEU LYS GLU ALA ILE          
SEQRES  16 S  241  LYS SER SER LEU ILE ILE LEU LYS GLN VAL MET GLU GLU          
SEQRES  17 S  241  LYS LEU ASN ALA THR ASN ILE GLU LEU ALA THR VAL GLN          
SEQRES  18 S  241  PRO GLY GLN ASN PHE HIS MET PHE THR LYS GLU GLU LEU          
SEQRES  19 S  241  GLU GLU VAL ILE LYS ASP ILE                                  
SEQRES   1 T  263  MET PHE ARG ASN GLN TYR ASP ASN ASP VAL THR VAL TRP          
SEQRES   2 T  263  SER PRO GLN GLY ARG ILE HIS GLN ILE GLU TYR ALA MET          
SEQRES   3 T  263  GLU ALA VAL LYS GLN GLY SER ALA THR VAL GLY LEU LYS          
SEQRES   4 T  263  SER LYS THR HIS ALA VAL LEU VAL ALA LEU LYS ARG ALA          
SEQRES   5 T  263  GLN SER GLU LEU ALA ALA HIS GLN LYS LYS ILE LEU HIS          
SEQRES   6 T  263  VAL ASP ASN HIS ILE GLY ILE SER ILE ALA GLY LEU THR          
SEQRES   7 T  263  ALA ASP ALA ARG LEU LEU CYS ASN PHE MET ARG GLN GLU          
SEQRES   8 T  263  CYS LEU ASP SER ARG PHE VAL PHE ASP ARG PRO LEU PRO          
SEQRES   9 T  263  VAL SER ARG LEU VAL SER LEU ILE GLY SER LYS THR GLN          
SEQRES  10 T  263  ILE PRO THR GLN ARG TYR GLY ARG ARG PRO TYR GLY VAL          
SEQRES  11 T  263  GLY LEU LEU ILE ALA GLY TYR ASP ASP MET GLY PRO HIS          
SEQRES  12 T  263  ILE PHE GLN THR CYS PRO SER ALA ASN TYR PHE ASP CYS          
SEQRES  13 T  263  ARG ALA MET SER ILE GLY ALA ARG SER GLN SER ALA ARG          
SEQRES  14 T  263  THR TYR LEU GLU ARG HIS MET SER GLU PHE MET GLU CYS          
SEQRES  15 T  263  ASN LEU ASN GLU LEU VAL LYS HIS GLY LEU ARG ALA LEU          
SEQRES  16 T  263  ARG GLU THR LEU PRO ALA GLU GLN ASP LEU THR THR LYS          
SEQRES  17 T  263  ASN VAL SER ILE GLY ILE VAL GLY LYS ASP LEU GLU PHE          
SEQRES  18 T  263  THR ILE TYR ASP ASP ASP ASP VAL SER PRO PHE LEU GLU          
SEQRES  19 T  263  GLY LEU GLU GLU ARG PRO GLN ARG LYS ALA GLN PRO ALA          
SEQRES  20 T  263  GLN PRO ALA ASP GLU PRO ALA GLU LYS ALA ASP GLU PRO          
SEQRES  21 T  263  MET GLU HIS                                                  
SEQRES   1 U  255  MET SER SER ILE GLY THR GLY TYR ASP LEU SER ALA SER          
SEQRES   2 U  255  THR PHE SER PRO ASP GLY ARG VAL PHE GLN VAL GLU TYR          
SEQRES   3 U  255  ALA MET LYS ALA VAL GLU ASN SER SER THR ALA ILE GLY          
SEQRES   4 U  255  ILE ARG CYS LYS ASP GLY VAL VAL PHE GLY VAL GLU LYS          
SEQRES   5 U  255  LEU VAL LEU SER LYS LEU TYR GLU GLU GLY SER ASN LYS          
SEQRES   6 U  255  ARG LEU PHE ASN VAL ASP ARG HIS VAL GLY MET ALA VAL          
SEQRES   7 U  255  ALA GLY LEU LEU ALA ASP ALA ARG SER LEU ALA ASP ILE          
SEQRES   8 U  255  ALA ARG GLU GLU ALA SER ASN PHE ARG SER ASN PHE GLY          
SEQRES   9 U  255  TYR ASN ILE PRO LEU LYS HIS LEU ALA ASP ARG VAL ALA          
SEQRES  10 U  255  MET TYR VAL HIS ALA TYR THR LEU TYR SER ALA VAL ARG          
SEQRES  11 U  255  PRO PHE GLY CYS SER PHE MET LEU GLY SER TYR SER VAL          
SEQRES  12 U  255  ASN ASP GLY ALA GLN LEU TYR MET ILE ASP PRO SER GLY          
SEQRES  13 U  255  VAL SER TYR GLY TYR TRP GLY CYS ALA ILE GLY LYS ALA          
SEQRES  14 U  255  ARG GLN ALA ALA LYS THR GLU ILE GLU LYS LEU GLN MET          
SEQRES  15 U  255  LYS GLU MET THR CYS ARG ASP ILE VAL LYS GLU VAL ALA          
SEQRES  16 U  255  LYS ILE ILE TYR ILE VAL HIS ASP GLU VAL LYS ASP LYS          
SEQRES  17 U  255  ALA PHE GLU LEU GLU LEU SER TRP VAL GLY GLU LEU THR          
SEQRES  18 U  255  ASN GLY ARG HIS GLU ILE VAL PRO LYS ASP ILE ARG GLU          
SEQRES  19 U  255  GLU ALA GLU LYS TYR ALA LYS GLU SER LEU LYS GLU GLU          
SEQRES  20 U  255  ASP GLU SER ASP ASP ASP ASN MET                              
SEQRES   1 V  205  THR THR ILE MET ALA VAL GLN PHE ASP GLY GLY VAL VAL          
SEQRES   2 V  205  LEU GLY ALA ASP SER ARG THR THR THR GLY SER TYR ILE          
SEQRES   3 V  205  ALA ASN ARG VAL THR ASP LYS LEU THR PRO ILE HIS ASP          
SEQRES   4 V  205  ARG ILE PHE CYS CYS ARG SER GLY SER ALA ALA ASP THR          
SEQRES   5 V  205  GLN ALA VAL ALA ASP ALA VAL THR TYR GLN LEU GLY PHE          
SEQRES   6 V  205  HIS SER ILE GLU LEU ASN GLU PRO PRO LEU VAL HIS THR          
SEQRES   7 V  205  ALA ALA SER LEU PHE LYS GLU MET CYS TYR ARG TYR ARG          
SEQRES   8 V  205  GLU ASP LEU MET ALA GLY ILE ILE ILE ALA GLY TRP ASP          
SEQRES   9 V  205  PRO GLN GLU GLY GLY GLN VAL TYR SER VAL PRO MET GLY          
SEQRES  10 V  205  GLY MET MET VAL ARG GLN SER PHE ALA ILE GLY GLY SER          
SEQRES  11 V  205  GLY SER SER TYR ILE TYR GLY TYR VAL ASP ALA THR TYR          
SEQRES  12 V  205  ARG GLU GLY MET THR LYS GLU GLU CYS LEU GLN PHE THR          
SEQRES  13 V  205  ALA ASN ALA LEU ALA LEU ALA MET GLU ARG ASP GLY SER          
SEQRES  14 V  205  SER GLY GLY VAL ILE ARG LEU ALA ALA ILE ALA GLU SER          
SEQRES  15 V  205  GLY VAL GLU ARG GLN VAL LEU LEU GLY ASP GLN ILE PRO          
SEQRES  16 V  205  LYS PHE ALA VAL ALA THR LEU PRO PRO ALA                      
SEQRES   1 W  234  THR THR ILE ALA GLY VAL VAL TYR LYS ASP GLY ILE VAL          
SEQRES   2 W  234  LEU GLY ALA ASP THR ARG ALA THR GLU GLY MET VAL VAL          
SEQRES   3 W  234  ALA ASP LYS ASN CYS SER LYS ILE HIS PHE ILE SER PRO          
SEQRES   4 W  234  ASN ILE TYR CYS CYS GLY ALA GLY THR ALA ALA ASP THR          
SEQRES   5 W  234  ASP MET THR THR GLN LEU ILE SER SER ASN LEU GLU LEU          
SEQRES   6 W  234  HIS SER LEU SER THR GLY ARG LEU PRO ARG VAL VAL THR          
SEQRES   7 W  234  ALA ASN ARG MET LEU LYS GLN MET LEU PHE ARG TYR GLN          
SEQRES   8 W  234  GLY TYR ILE GLY ALA ALA LEU VAL LEU GLY GLY VAL ASP          
SEQRES   9 W  234  VAL THR GLY PRO HIS LEU TYR SER ILE TYR PRO HIS GLY          
SEQRES  10 W  234  SER THR ASP LYS LEU PRO TYR VAL THR MET GLY SER GLY          
SEQRES  11 W  234  SER LEU ALA ALA MET ALA VAL PHE GLU ASP LYS PHE ARG          
SEQRES  12 W  234  PRO ASP MET GLU GLU GLU GLU ALA LYS ASN LEU VAL SER          
SEQRES  13 W  234  GLU ALA ILE ALA ALA GLY ILE PHE ASN ASP LEU GLY SER          
SEQRES  14 W  234  GLY SER ASN ILE ASP LEU CYS VAL ILE SER LYS ASN LYS          
SEQRES  15 W  234  LEU ASP PHE LEU ARG PRO TYR THR VAL PRO ASN LYS LYS          
SEQRES  16 W  234  GLY THR ARG LEU GLY ARG TYR ARG CYS GLU LYS GLY THR          
SEQRES  17 W  234  THR ALA VAL LEU THR GLU LYS ILE THR PRO LEU GLU ILE          
SEQRES  18 W  234  GLU VAL LEU GLU GLU THR VAL GLN THR MET ASP THR SER          
SEQRES   1 X  204  SER ILE MET SER TYR ASN GLY GLY ALA VAL MET ALA MET          
SEQRES   2 X  204  LYS GLY LYS ASN CYS VAL ALA ILE ALA ALA ASP ARG ARG          
SEQRES   3 X  204  PHE GLY ILE GLN ALA GLN MET VAL THR THR ASP PHE GLN          
SEQRES   4 X  204  LYS ILE PHE PRO MET GLY ASP ARG LEU TYR ILE GLY LEU          
SEQRES   5 X  204  ALA GLY LEU ALA THR ASP VAL GLN THR VAL ALA GLN ARG          
SEQRES   6 X  204  LEU LYS PHE ARG LEU ASN LEU TYR GLU LEU LYS GLU GLY          
SEQRES   7 X  204  ARG GLN ILE LYS PRO TYR THR LEU MET SER MET VAL ALA          
SEQRES   8 X  204  ASN LEU LEU TYR GLU LYS ARG PHE GLY PRO TYR TYR THR          
SEQRES   9 X  204  GLU PRO VAL ILE ALA GLY LEU ASP PRO LYS THR PHE LYS          
SEQRES  10 X  204  PRO PHE ILE CYS SER LEU ASP LEU ILE GLY CYS PRO MET          
SEQRES  11 X  204  VAL THR ASP ASP PHE VAL VAL SER GLY THR CYS ALA GLU          
SEQRES  12 X  204  GLN MET TYR GLY MET CYS GLU SER LEU TRP GLU PRO ASN          
SEQRES  13 X  204  MET ASP PRO ASP HIS LEU PHE GLU THR ILE SER GLN ALA          
SEQRES  14 X  204  MET LEU ASN ALA VAL ASP ARG ASP ALA VAL SER GLY MET          
SEQRES  15 X  204  GLY VAL ILE VAL HIS ILE ILE GLU LYS ASP LYS ILE THR          
SEQRES  16 X  204  THR ARG THR LEU LYS ALA ARG MET ASP                          
SEQRES   1 Y  201  MET GLU TYR LEU ILE GLY ILE GLN GLY PRO ASP TYR VAL          
SEQRES   2 Y  201  LEU VAL ALA SER ASP ARG VAL ALA ALA SER ASN ILE VAL          
SEQRES   3 Y  201  GLN MET LYS ASP ASP HIS ASP LYS MET PHE LYS MET SER          
SEQRES   4 Y  201  GLU LYS ILE LEU LEU LEU CYS VAL GLY GLU ALA GLY ASP          
SEQRES   5 Y  201  THR VAL GLN PHE ALA GLU TYR ILE GLN LYS ASN VAL GLN          
SEQRES   6 Y  201  LEU TYR LYS MET ARG ASN GLY TYR GLU LEU SER PRO THR          
SEQRES   7 Y  201  ALA ALA ALA ASN PHE THR ARG ARG ASN LEU ALA ASP CYS          
SEQRES   8 Y  201  LEU ARG SER ARG THR PRO TYR HIS VAL ASN LEU LEU LEU          
SEQRES   9 Y  201  ALA GLY TYR ASP GLU HIS GLU GLY PRO ALA LEU TYR TYR          
SEQRES  10 Y  201  MET ASP TYR LEU ALA ALA LEU ALA LYS ALA PRO PHE ALA          
SEQRES  11 Y  201  ALA HIS GLY TYR GLY ALA PHE LEU THR LEU SER ILE LEU          
SEQRES  12 Y  201  ASP ARG TYR TYR THR PRO THR ILE SER ARG GLU ARG ALA          
SEQRES  13 Y  201  VAL GLU LEU LEU ARG LYS CYS LEU GLU GLU LEU GLN LYS          
SEQRES  14 Y  201  ARG PHE ILE LEU ASN LEU PRO THR PHE SER VAL ARG ILE          
SEQRES  15 Y  201  ILE ASP LYS ASN GLY ILE HIS ASP LEU ASP ASN ILE SER          
SEQRES  16 Y  201  PHE PRO LYS GLN GLY SER                                      
SEQRES   1 Z  204  THR THR THR LEU ALA PHE LYS PHE ARG HIS GLY VAL ILE          
SEQRES   2 Z  204  VAL ALA ALA ASP SER ARG ALA THR ALA GLY ALA TYR ILE          
SEQRES   3 Z  204  ALA SER GLN THR VAL LYS LYS VAL ILE GLU ILE ASN PRO          
SEQRES   4 Z  204  TYR LEU LEU GLY THR MET ALA GLY GLY ALA ALA ASP CYS          
SEQRES   5 Z  204  SER PHE TRP GLU ARG LEU LEU ALA ARG GLN CYS ARG ILE          
SEQRES   6 Z  204  TYR GLU LEU ARG ASN LYS GLU ARG ILE SER VAL ALA ALA          
SEQRES   7 Z  204  ALA SER LYS LEU LEU ALA ASN MET VAL TYR GLN TYR LYS          
SEQRES   8 Z  204  GLY MET GLY LEU SER MET GLY THR MET ILE CYS GLY TRP          
SEQRES   9 Z  204  ASP LYS ARG GLY PRO GLY LEU TYR TYR VAL ASP SER GLU          
SEQRES  10 Z  204  GLY ASN ARG ILE SER GLY ALA THR PHE SER VAL GLY SER          
SEQRES  11 Z  204  GLY SER VAL TYR ALA TYR GLY VAL MET ASP ARG GLY TYR          
SEQRES  12 Z  204  SER TYR ASP LEU GLU VAL GLU GLN ALA TYR ASP LEU ALA          
SEQRES  13 Z  204  ARG ARG ALA ILE TYR GLN ALA THR TYR ARG ASP ALA TYR          
SEQRES  14 Z  204  SER GLY GLY ALA VAL ASN LEU TYR HIS VAL ARG GLU ASP          
SEQRES  15 Z  204  GLY TRP ILE ARG VAL SER SER ASP ASN VAL ALA ASP LEU          
SEQRES  16 Z  204  HIS GLU LYS TYR SER GLY SER THR PRO                          
SEQRES   1 a  213  ARG PHE SER PRO TYR VAL PHE ASN GLY GLY THR ILE LEU          
SEQRES   2 a  213  ALA ILE ALA GLY GLU ASP PHE ALA ILE VAL ALA SER ASP          
SEQRES   3 a  213  THR ARG LEU SER GLU GLY PHE SER ILE HIS THR ARG ASP          
SEQRES   4 a  213  SER PRO LYS CYS TYR LYS LEU THR ASP LYS THR VAL ILE          
SEQRES   5 a  213  GLY CYS SER GLY PHE HIS GLY ASP CYS LEU THR LEU THR          
SEQRES   6 a  213  LYS ILE ILE GLU ALA ARG LEU LYS MET TYR LYS HIS SER          
SEQRES   7 a  213  ASN ASN LYS ALA MET THR THR GLY ALA ILE ALA ALA MET          
SEQRES   8 a  213  LEU SER THR ILE LEU TYR SER ARG ARG PHE PHE PRO TYR          
SEQRES   9 a  213  TYR VAL TYR ASN ILE ILE GLY GLY LEU ASP GLU GLU GLY          
SEQRES  10 a  213  LYS GLY ALA VAL TYR SER PHE ASP PRO VAL GLY SER TYR          
SEQRES  11 a  213  GLN ARG ASP SER PHE LYS ALA GLY GLY SER ALA SER ALA          
SEQRES  12 a  213  MET LEU GLN PRO LEU LEU ASP ASN GLN VAL GLY PHE LYS          
SEQRES  13 a  213  ASN MET GLN ASN VAL GLU HIS VAL PRO LEU SER LEU ASP          
SEQRES  14 a  213  ARG ALA MET ARG LEU VAL LYS ASP VAL PHE ILE SER ALA          
SEQRES  15 a  213  ALA GLU ARG ASP VAL TYR THR GLY ASP ALA LEU ARG ILE          
SEQRES  16 a  213  CYS ILE VAL THR LYS GLU GLY ILE ARG GLU GLU THR VAL          
SEQRES  17 a  213  SER LEU ARG LYS ASP                                          
SEQRES   1 b  219  THR GLN ASN PRO MET VAL THR GLY THR SER VAL LEU GLY          
SEQRES   2 b  219  VAL LYS PHE GLU GLY GLY VAL VAL ILE ALA ALA ASP MET          
SEQRES   3 b  219  LEU GLY SER TYR GLY SER LEU ALA ARG PHE ARG ASN ILE          
SEQRES   4 b  219  SER ARG ILE MET ARG VAL ASN ASN SER THR MET LEU GLY          
SEQRES   5 b  219  ALA SER GLY ASP TYR ALA ASP PHE GLN TYR LEU LYS GLN          
SEQRES   6 b  219  VAL LEU GLY GLN MET VAL ILE ASP GLU GLU LEU LEU GLY          
SEQRES   7 b  219  ASP GLY HIS SER TYR SER PRO ARG ALA ILE HIS SER TRP          
SEQRES   8 b  219  LEU THR ARG ALA MET TYR SER ARG ARG SER LYS MET ASN          
SEQRES   9 b  219  PRO LEU TRP ASN THR MET VAL ILE GLY GLY TYR ALA ASP          
SEQRES  10 b  219  GLY GLU SER PHE LEU GLY TYR VAL ASP MET LEU GLY VAL          
SEQRES  11 b  219  ALA TYR GLU ALA PRO SER LEU ALA THR GLY TYR GLY ALA          
SEQRES  12 b  219  TYR LEU ALA GLN PRO LEU LEU ARG GLU VAL LEU GLU LYS          
SEQRES  13 b  219  GLN PRO VAL LEU SER GLN THR GLU ALA ARG ASP LEU VAL          
SEQRES  14 b  219  GLU ARG CYS MET ARG VAL LEU TYR TYR ARG ASP ALA ARG          
SEQRES  15 b  219  SER TYR ASN ARG PHE GLN ILE ALA THR VAL THR GLU LYS          
SEQRES  16 b  219  GLY VAL GLU ILE GLU GLY PRO LEU SER THR GLU THR ASN          
SEQRES  17 b  219  TRP ASP ILE ALA HIS MET ILE SER GLY PHE GLU                  
HET    KNM  H 300      31                                                       
HET    KNM  I 300      30                                                       
HET    KNM  L 300      31                                                       
HET    KNM  V 300      31                                                       
HET    KNM  W 300      30                                                       
HET    KNM  Z 300      31                                                       
HETNAM     KNM ADA-(AHX)3-(LEU)3-VINYL SULFONE                                  
FORMUL  29  KNM    6(C51 H92 N6 O8 S)                                           
HELIX    1   1 TYR A   23  GLY A   35  1                                  13    
HELIX    2   2 THR A   84  TYR A  105  1                                  22    
HELIX    3   3 VAL A  111  GLN A  127  1                                  17    
HELIX    4   4 GLN A  172  LYS A  181  1                                  10    
HELIX    5   5 THR A  194  LEU A  206  1                                  13    
HELIX    6   6 PRO A  212  GLU A  214  1                                   3    
HELIX    7   7 VAL B   19  ALA B   29  1                                  11    
HELIX    8   8 GLY B   79  TYR B  100  1                                  22    
HELIX    9   9 THR B  106  GLN B  122  1                                  17    
HELIX   10  10 TYR B  166  ARG B  176  1                                  11    
HELIX   11  11 LEU B  183  GLU B  196  1                                  14    
HELIX   12  12 ARG C    3  TYR C    5  1                                   3    
HELIX   13  13 TYR C   19  HIS C   30  1                                  12    
HELIX   14  14 ASP C   82  TYR C  101  1                                  20    
HELIX   15  15 CYS C  107  GLN C  123  1                                  17    
HELIX   16  16 SER C  168  ASP C  178  1                                  11    
HELIX   17  17 LEU C  186  THR C  200  1                                  15    
HELIX   18  18 GLN C  230  GLU C  243  1                                  14    
HELIX   19  19 PHE D   17  LYS D   28  1                                  12    
HELIX   20  20 THR D   77  THR D   97  1                                  21    
HELIX   21  21 VAL D  104  THR D  119  1                                  16    
HELIX   22  22 ALA D  165  LYS D  174  1                                  10    
HELIX   23  23 ASP D  185  VAL D  198  1                                  14    
HELIX   24  24 GLU D  223  LYS D  234  1                                  12    
HELIX   25  25 PHE E   22  LEU E   33  1                                  12    
HELIX   26  26 ILE E   82  TYR E  103  1                                  22    
HELIX   27  27 VAL E  109  ALA E  120  1                                  12    
HELIX   28  28 SER E  174  VAL E  184  1                                  11    
HELIX   29  29 LEU E  191  VAL E  205  1                                  15    
HELIX   30  30 LYS E  231  GLU E  235  1                                   5    
HELIX   31  31 HIS F   20  GLN F   31  1                                  12    
HELIX   32  32 THR F   78  VAL F   98  1                                  21    
HELIX   33  33 VAL F  105  GLN F  121  1                                  17    
HELIX   34  34 SER F  165  ARG F  174  1                                  10    
HELIX   35  35 LEU F  184  ARG F  196  1                                  13    
HELIX   36  36 PHE G   21  ASN G   32  1                                  12    
HELIX   37  37 LEU G   81  PHE G  102  1                                  22    
HELIX   38  38 LEU G  108  LEU G  124  1                                  17    
HELIX   39  39 ALA G  172  LYS G  178  1                                   7    
HELIX   40  40 CYS G  186  VAL G  200  1                                  15    
HELIX   41  41 LYS G  229  GLU G  236  1                                   8    
HELIX   42  42 ALA H   49  ALA H   54  1                                   6    
HELIX   43  43 ASP H   57  LEU H   70  1                                  14    
HELIX   44  44 VAL H   76  ARG H   89  1                                  14    
HELIX   45  45 SER H  132  ASP H  140  1                                   9    
HELIX   46  46 LYS H  149  ARG H  166  1                                  18    
HELIX   47  47 ALA I   49  THR I   70  1                                  22    
HELIX   48  48 VAL I   76  ARG I   89  1                                  14    
HELIX   49  49 GLY I  130  LYS I  141  1                                  12    
HELIX   50  50 GLU I  148  ASN I  165  1                                  18    
HELIX   51  51 ALA J   56  LYS J   76  1                                  21    
HELIX   52  52 PRO J   83  GLU J   96  1                                  14    
HELIX   53  53 PRO J  159  ARG J  176  1                                  18    
HELIX   54  54 GLY K   51  ASN K   71  1                                  21    
HELIX   55  55 PRO K   77  ARG K   93  1                                  17    
HELIX   56  56 GLY K  135  TYR K  146  1                                  12    
HELIX   57  57 ARG K  153  ARG K  170  1                                  18    
HELIX   58  58 ALA L   49  ASN L   70  1                                  22    
HELIX   59  59 VAL L   76  TYR L   90  1                                  15    
HELIX   60  60 SER L  132  GLY L  142  1                                  11    
HELIX   61  61 VAL L  149  ARG L  166  1                                  18    
HELIX   62  62 HIS M   58  ASN M   79  1                                  22    
HELIX   63  63 THR M   85  SER M   98  1                                  14    
HELIX   64  64 SER M  142  VAL M  153  1                                  12    
HELIX   65  65 LEU M  168  ARG M  185  1                                  18    
HELIX   66  66 TYR N   57  LEU N   76  1                                  20    
HELIX   67  67 PRO N   85  LYS N  102  1                                  18    
HELIX   68  68 ALA N  146  LYS N  156  1                                  11    
HELIX   69  69 THR N  163  ARG N  174  1                                  12    
HELIX   70  70 TYR O   23  GLY O   35  1                                  13    
HELIX   71  71 THR O   84  TYR O  105  1                                  22    
HELIX   72  72 VAL O  111  GLN O  127  1                                  17    
HELIX   73  73 GLN O  172  LYS O  181  1                                  10    
HELIX   74  74 THR O  194  LEU O  206  1                                  13    
HELIX   75  75 PRO O  212  GLU O  214  1                                   3    
HELIX   76  76 VAL P   19  ALA P   29  1                                  11    
HELIX   77  77 GLY P   79  TYR P  100  1                                  22    
HELIX   78  78 THR P  106  GLN P  122  1                                  17    
HELIX   79  79 TYR P  166  ARG P  176  1                                  11    
HELIX   80  80 LEU P  183  GLU P  196  1                                  14    
HELIX   81  81 ARG Q    3  TYR Q    5  1                                   3    
HELIX   82  82 TYR Q   19  HIS Q   30  1                                  12    
HELIX   83  83 ASP Q   82  TYR Q  101  1                                  20    
HELIX   84  84 CYS Q  107  GLN Q  123  1                                  17    
HELIX   85  85 SER Q  168  ASP Q  178  1                                  11    
HELIX   86  86 LEU Q  186  THR Q  200  1                                  15    
HELIX   87  87 GLN Q  230  GLU Q  243  1                                  14    
HELIX   88  88 PHE R   17  LYS R   28  1                                  12    
HELIX   89  89 THR R   77  THR R   97  1                                  21    
HELIX   90  90 VAL R  104  THR R  119  1                                  16    
HELIX   91  91 ALA R  165  LYS R  174  1                                  10    
HELIX   92  92 ASP R  185  VAL R  198  1                                  14    
HELIX   93  93 GLU R  223  LYS R  234  1                                  12    
HELIX   94  94 PHE S   22  LEU S   33  1                                  12    
HELIX   95  95 ILE S   82  TYR S  103  1                                  22    
HELIX   96  96 VAL S  109  ALA S  120  1                                  12    
HELIX   97  97 SER S  174  VAL S  184  1                                  11    
HELIX   98  98 LEU S  191  VAL S  205  1                                  15    
HELIX   99  99 LYS S  231  GLU S  235  1                                   5    
HELIX  100 100 HIS T   20  GLN T   31  1                                  12    
HELIX  101 101 THR T   78  VAL T   98  1                                  21    
HELIX  102 102 VAL T  105  GLN T  121  1                                  17    
HELIX  103 103 SER T  165  ARG T  174  1                                  10    
HELIX  104 104 LEU T  184  ARG T  196  1                                  13    
HELIX  105 105 PHE U   21  ASN U   32  1                                  12    
HELIX  106 106 LEU U   81  PHE U  102  1                                  22    
HELIX  107 107 LEU U  108  LEU U  124  1                                  17    
HELIX  108 108 ALA U  172  LYS U  178  1                                   7    
HELIX  109 109 CYS U  186  VAL U  200  1                                  15    
HELIX  110 110 LYS U  229  GLU U  236  1                                   8    
HELIX  111 111 ALA V   49  ALA V   54  1                                   6    
HELIX  112 112 ASP V   57  LEU V   70  1                                  14    
HELIX  113 113 VAL V   76  ARG V   89  1                                  14    
HELIX  114 114 SER V  132  ASP V  140  1                                   9    
HELIX  115 115 LYS V  149  ARG V  166  1                                  18    
HELIX  116 116 ALA W   49  THR W   70  1                                  22    
HELIX  117 117 VAL W   76  ARG W   89  1                                  14    
HELIX  118 118 GLY W  130  LYS W  141  1                                  12    
HELIX  119 119 GLU W  148  ASN W  165  1                                  18    
HELIX  120 120 ALA X   56  LYS X   76  1                                  21    
HELIX  121 121 PRO X   83  GLU X   96  1                                  14    
HELIX  122 122 PRO X  159  ARG X  176  1                                  18    
HELIX  123 123 GLY Y   51  ASN Y   71  1                                  21    
HELIX  124 124 PRO Y   77  ARG Y   93  1                                  17    
HELIX  125 125 GLY Y  135  TYR Y  146  1                                  12    
HELIX  126 126 ARG Y  153  ARG Y  170  1                                  18    
HELIX  127 127 ALA Z   49  ASN Z   70  1                                  22    
HELIX  128 128 VAL Z   76  TYR Z   90  1                                  15    
HELIX  129 129 SER Z  132  GLY Z  142  1                                  11    
HELIX  130 130 VAL Z  149  ARG Z  166  1                                  18    
HELIX  131 131 HIS a   58  ASN a   79  1                                  22    
HELIX  132 132 THR a   85  SER a   98  1                                  14    
HELIX  133 133 SER a  142  VAL a  153  1                                  12    
HELIX  134 134 LEU a  168  ARG a  185  1                                  18    
HELIX  135 135 TYR b   57  LEU b   76  1                                  20    
HELIX  136 136 PRO b   85  LYS b  102  1                                  18    
HELIX  137 137 ALA b  146  LYS b  156  1                                  11    
HELIX  138 138 THR b  163  ARG b  174  1                                  12    
SHEET    1   1 1 VAL A  40  ARG A  43  0                                        
SHEET    1   2 1 ALA A  48  THR A  52  0                                        
SHEET    1   3 1 PHE A  70  THR A  73  0                                        
SHEET    1   4 1 ILE A  76  THR A  81  0                                        
SHEET    1   5 1 CYS A 136  ASP A 144  0                                        
SHEET    1   6 1 GLY A 148  ASP A 155  0                                        
SHEET    1   7 1 GLY A 158  GLY A 162  0                                        
SHEET    1   8 1 GLU A 216  GLY A 218  0                                        
SHEET    1   9 1 SER B  34  ILE B  37  0                                        
SHEET    1  10 1 VAL B  44  THR B  47  0                                        
SHEET    1  11 1 GLU B  65  THR B  68  0                                        
SHEET    1  12 1 ILE B  71  SER B  76  0                                        
SHEET    1  13 1 SER B 132  ASN B 139  0                                        
SHEET    1  14 1 ARG B 142  ASP B 149  0                                        
SHEET    1  15 1 GLY B 152  ALA B 156  0                                        
SHEET    1  16 1 ALA B 159  MET B 162  0                                        
SHEET    1  17 1 GLU B 208  ILE B 211  0                                        
SHEET    1  18 1 CYS C  34  LEU C  38  0                                        
SHEET    1  19 1 VAL C  43  GLU C  48  0                                        
SHEET    1  20 1 ILE C  65  LYS C  67  0                                        
SHEET    1  21 1 MET C  72  VAL C  76  0                                        
SHEET    1  22 1 LEU C 134  ASP C 140  0                                        
SHEET    1  23 1 TYR C 143  SER C 150  0                                        
SHEET    1  24 1 ALA C 161  ILE C 164  0                                        
SHEET    1  25 1 VAL C 211  GLU C 219  0                                        
SHEET    1  26 1 LYS C 222  VAL C 227  0                                        
SHEET    1  27 1 ALA D  32  ARG D  36  0                                        
SHEET    1  28 1 VAL D  41  GLY D  44  0                                        
SHEET    1  29 1 VAL D  69  ALA D  74  0                                        
SHEET    1  30 1 SER D 130  ASP D 137  0                                        
SHEET    1  31 1 GLY D 140  ASP D 148  0                                        
SHEET    1  32 1 GLY D 151  ALA D 155  0                                        
SHEET    1  33 1 ALA D 158  ILE D 161  0                                        
SHEET    1  34 1 ALA E  37  GLN E  41  0                                        
SHEET    1  35 1 VAL E  46  GLU E  51  0                                        
SHEET    1  36 1 ILE E  67  GLU E  69  0                                        
SHEET    1  37 1 ILE E  74  SER E  79  0                                        
SHEET    1  38 1 ALA E 140  VAL E 146  0                                        
SHEET    1  39 1 PRO E 151  ASP E 157  0                                        
SHEET    1  40 1 GLY E 160  GLN E 164  0                                        
SHEET    1  41 1 ALA E 167  ILE E 170  0                                        
SHEET    1  42 1 ILE E 215  VAL E 220  0                                        
SHEET    1  43 1 THR F  35  SER F  40  0                                        
SHEET    1  44 1 HIS F  43  LEU F  49  0                                        
SHEET    1  45 1 ILE F  63  HIS F  65  0                                        
SHEET    1  46 1 ILE F  70  ALA F  75  0                                        
SHEET    1  47 1 GLY F 131  GLY F 136  0                                        
SHEET    1  48 1 HIS F 143  THR F 147  0                                        
SHEET    1  49 1 MET F 159  ILE F 161  0                                        
SHEET    1  50 1 VAL F 210  GLY F 216  0                                        
SHEET    1  51 1 THR F 222  TYR F 224  0                                        
SHEET    1  52 1 ALA G  36  ARG G  40  0                                        
SHEET    1  53 1 VAL G  45  VAL G  49  0                                        
SHEET    1  54 1 GLY G  74  ALA G  78  0                                        
SHEET    1  55 1 SER G 134  TYR G 140  0                                        
SHEET    1  56 1 ALA G 146  ASP G 152  0                                        
SHEET    1  57 1 GLY G 155  GLY G 159  0                                        
SHEET    1  58 1 GLY G 162  ILE G 165  0                                        
SHEET    1  59 1 GLU G 212  SER G 214  0                                        
SHEET    1  60 1 THR H   2  VAL H   6  0                                        
SHEET    1  61 1 VAL H  13  ALA H  16  0                                        
SHEET    1  62 1 PHE H  42  SER H  46  0                                        
SHEET    1  63 1 ALA H  96  ALA H 101  0                                        
SHEET    1  64 1 TYR H 112  VAL H 114  0                                        
SHEET    1  65 1 ALA H 126  GLY H 128  0                                        
SHEET    1  66 1 ARG H 175  ALA H 180  0                                        
SHEET    1  67 1 GLY H 183  GLN H 187  0                                        
SHEET    1  68 1 THR I   2  TYR I   8  0                                        
SHEET    1  69 1 GLY I  11  ASP I  17  0                                        
SHEET    1  70 1 ALA I  20  GLU I  22  0                                        
SHEET    1  71 1 VAL I  25  ASP I  28  0                                        
SHEET    1  72 1 ILE I  34  PHE I  36  0                                        
SHEET    1  73 1 TYR I  42  ALA I  46  0                                        
SHEET    1  74 1 ALA I  97  VAL I 103  0                                        
SHEET    1  75 1 PRO I 108  TYR I 114  0                                        
SHEET    1  76 1 GLY I 117  LYS I 121  0                                        
SHEET    1  77 1 TYR I 124  MET I 127  0                                        
SHEET    1  78 1 ILE I 173  SER I 179  0                                        
SHEET    1  79 1 LYS I 182  PHE I 185  0                                        
SHEET    1  80 1 ALA J   9  LYS J  14  0                                        
SHEET    1  81 1 VAL J  19  ILE J  29  0                                        
SHEET    1  82 1 GLN J  32  THR J  35  0                                        
SHEET    1  83 1 TYR J  49  ALA J  53  0                                        
SHEET    1  84 1 THR J 104  ASP J 112  0                                        
SHEET    1  85 1 PHE J 116  SER J 122  0                                        
SHEET    1  86 1 PHE J 135  SER J 138  0                                        
SHEET    1  87 1 VAL J 184  ILE J 189  0                                        
SHEET    1  88 1 LEU K   4  GLY K   9  0                                        
SHEET    1  89 1 TYR K  12  ASP K  18  0                                        
SHEET    1  90 1 MET K  35  LYS K  37  0                                        
SHEET    1  91 1 ILE K  42  VAL K  47  0                                        
SHEET    1  92 1 ASN K 101  TYR K 107  0                                        
SHEET    1  93 1 PRO K 113  ASP K 119  0                                        
SHEET    1  94 1 ALA K 122  LYS K 126  0                                        
SHEET    1  95 1 PHE K 129  HIS K 132  0                                        
SHEET    1  96 1 PHE K 178  ILE K 183  0                                        
SHEET    1  97 1 THR L   3  PHE L   8  0                                        
SHEET    1  98 1 GLY L  11  ALA L  16  0                                        
SHEET    1  99 1 ALA L  20  ALA L  22  0                                        
SHEET    1 100 1 TYR L  25  SER L  28  0                                        
SHEET    1 101 1 MET L 100  TRP L 104  0                                        
SHEET    1 102 1 PRO L 109  ASP L 115  0                                        
SHEET    1 103 1 GLY L 118  ILE L 121  0                                        
SHEET    1 104 1 LEU L 176  ARG L 180  0                                        
SHEET    1 105 1 GLY L 183  SER L 188  0                                        
SHEET    1 106 1 THR M  11  ILE M  15  0                                        
SHEET    1 107 1 ALA M  21  ASP M  26  0                                        
SHEET    1 108 1 LEU M  29  GLU M  31  0                                        
SHEET    1 109 1 SER M  34  THR M  37  0                                        
SHEET    1 110 1 CYS M  43  LYS M  45  0                                        
SHEET    1 111 1 VAL M  51  SER M  55  0                                        
SHEET    1 112 1 TYR M 107  GLY M 111  0                                        
SHEET    1 113 1 PHE M 135  GLY M 138  0                                        
SHEET    1 114 1 LEU M 193  THR M 199  0                                        
SHEET    1 115 1 GLY M 202  ARG M 204  0                                        
SHEET    1 116 1 LEU N  12  PHE N  16  0                                        
SHEET    1 117 1 GLY N  19  ALA N  24  0                                        
SHEET    1 118 1 ILE N  42  ASN N  46  0                                        
SHEET    1 119 1 THR N  49  SER N  54  0                                        
SHEET    1 120 1 THR N 109  ALA N 116  0                                        
SHEET    1 121 1 GLU N 119  ASP N 126  0                                        
SHEET    1 122 1 GLY N 129  GLU N 133  0                                        
SHEET    1 123 1 SER N 136  ALA N 138  0                                        
SHEET    1 124 1 GLN N 188  VAL N 192  0                                        
SHEET    1 125 1 VAL O  40  ARG O  43  0                                        
SHEET    1 126 1 ALA O  48  THR O  52  0                                        
SHEET    1 127 1 PHE O  70  THR O  73  0                                        
SHEET    1 128 1 ILE O  76  THR O  81  0                                        
SHEET    1 129 1 CYS O 136  ASP O 144  0                                        
SHEET    1 130 1 GLY O 148  ASP O 155  0                                        
SHEET    1 131 1 GLY O 158  GLY O 162  0                                        
SHEET    1 132 1 GLU O 216  GLY O 218  0                                        
SHEET    1 133 1 SER P  34  ILE P  37  0                                        
SHEET    1 134 1 VAL P  44  THR P  47  0                                        
SHEET    1 135 1 GLU P  65  THR P  68  0                                        
SHEET    1 136 1 ILE P  71  SER P  76  0                                        
SHEET    1 137 1 SER P 132  ASN P 139  0                                        
SHEET    1 138 1 ARG P 142  ASP P 149  0                                        
SHEET    1 139 1 GLY P 152  ALA P 156  0                                        
SHEET    1 140 1 ALA P 159  MET P 162  0                                        
SHEET    1 141 1 GLU P 208  ILE P 211  0                                        
SHEET    1 142 1 CYS Q  34  LEU Q  38  0                                        
SHEET    1 143 1 VAL Q  43  GLU Q  48  0                                        
SHEET    1 144 1 ILE Q  65  LYS Q  67  0                                        
SHEET    1 145 1 MET Q  72  VAL Q  76  0                                        
SHEET    1 146 1 LEU Q 134  ASP Q 140  0                                        
SHEET    1 147 1 TYR Q 143  SER Q 150  0                                        
SHEET    1 148 1 ALA Q 161  ILE Q 164  0                                        
SHEET    1 149 1 VAL Q 211  GLU Q 219  0                                        
SHEET    1 150 1 LYS Q 222  VAL Q 227  0                                        
SHEET    1 151 1 ALA R  32  ARG R  36  0                                        
SHEET    1 152 1 VAL R  41  GLY R  44  0                                        
SHEET    1 153 1 VAL R  69  ALA R  74  0                                        
SHEET    1 154 1 SER R 130  ASP R 137  0                                        
SHEET    1 155 1 GLY R 140  ASP R 148  0                                        
SHEET    1 156 1 GLY R 151  ALA R 155  0                                        
SHEET    1 157 1 ALA R 158  ILE R 161  0                                        
SHEET    1 158 1 ALA S  37  GLN S  41  0                                        
SHEET    1 159 1 VAL S  46  GLU S  51  0                                        
SHEET    1 160 1 ILE S  67  GLU S  69  0                                        
SHEET    1 161 1 ILE S  74  SER S  79  0                                        
SHEET    1 162 1 ALA S 140  VAL S 146  0                                        
SHEET    1 163 1 PRO S 151  ASP S 157  0                                        
SHEET    1 164 1 GLY S 160  GLN S 164  0                                        
SHEET    1 165 1 ALA S 167  ILE S 170  0                                        
SHEET    1 166 1 ILE S 215  VAL S 220  0                                        
SHEET    1 167 1 THR T  35  SER T  40  0                                        
SHEET    1 168 1 HIS T  43  LEU T  49  0                                        
SHEET    1 169 1 ILE T  63  HIS T  65  0                                        
SHEET    1 170 1 ILE T  70  ALA T  75  0                                        
SHEET    1 171 1 GLY T 131  GLY T 136  0                                        
SHEET    1 172 1 HIS T 143  THR T 147  0                                        
SHEET    1 173 1 MET T 159  ILE T 161  0                                        
SHEET    1 174 1 VAL T 210  GLY T 216  0                                        
SHEET    1 175 1 THR T 222  TYR T 224  0                                        
SHEET    1 176 1 ALA U  36  ARG U  40  0                                        
SHEET    1 177 1 VAL U  45  VAL U  49  0                                        
SHEET    1 178 1 GLY U  74  ALA U  78  0                                        
SHEET    1 179 1 SER U 134  TYR U 140  0                                        
SHEET    1 180 1 ALA U 146  ASP U 152  0                                        
SHEET    1 181 1 GLY U 155  GLY U 159  0                                        
SHEET    1 182 1 GLY U 162  ILE U 165  0                                        
SHEET    1 183 1 GLU U 212  SER U 214  0                                        
SHEET    1 184 1 THR V   2  VAL V   6  0                                        
SHEET    1 185 1 VAL V  13  ALA V  16  0                                        
SHEET    1 186 1 PHE V  42  SER V  46  0                                        
SHEET    1 187 1 ALA V  96  ALA V 101  0                                        
SHEET    1 188 1 TYR V 112  VAL V 114  0                                        
SHEET    1 189 1 ALA V 126  GLY V 128  0                                        
SHEET    1 190 1 ARG V 175  ALA V 180  0                                        
SHEET    1 191 1 GLY V 183  GLN V 187  0                                        
SHEET    1 192 1 THR W   2  TYR W   8  0                                        
SHEET    1 193 1 GLY W  11  ASP W  17  0                                        
SHEET    1 194 1 ALA W  20  GLU W  22  0                                        
SHEET    1 195 1 VAL W  25  ASP W  28  0                                        
SHEET    1 196 1 ILE W  34  PHE W  36  0                                        
SHEET    1 197 1 TYR W  42  ALA W  46  0                                        
SHEET    1 198 1 ALA W  97  VAL W 103  0                                        
SHEET    1 199 1 PRO W 108  TYR W 114  0                                        
SHEET    1 200 1 GLY W 117  LYS W 121  0                                        
SHEET    1 201 1 TYR W 124  MET W 127  0                                        
SHEET    1 202 1 ILE W 173  SER W 179  0                                        
SHEET    1 203 1 LYS W 182  PHE W 185  0                                        
SHEET    1 204 1 ALA X   9  LYS X  14  0                                        
SHEET    1 205 1 VAL X  19  ILE X  29  0                                        
SHEET    1 206 1 GLN X  32  THR X  35  0                                        
SHEET    1 207 1 TYR X  49  ALA X  53  0                                        
SHEET    1 208 1 THR X 104  ASP X 112  0                                        
SHEET    1 209 1 PHE X 116  SER X 122  0                                        
SHEET    1 210 1 PHE X 135  SER X 138  0                                        
SHEET    1 211 1 VAL X 184  ILE X 189  0                                        
SHEET    1 212 1 LEU Y   4  GLY Y   9  0                                        
SHEET    1 213 1 TYR Y  12  ASP Y  18  0                                        
SHEET    1 214 1 MET Y  35  LYS Y  37  0                                        
SHEET    1 215 1 ILE Y  42  VAL Y  47  0                                        
SHEET    1 216 1 ASN Y 101  TYR Y 107  0                                        
SHEET    1 217 1 PRO Y 113  ASP Y 119  0                                        
SHEET    1 218 1 ALA Y 122  LYS Y 126  0                                        
SHEET    1 219 1 PHE Y 129  HIS Y 132  0                                        
SHEET    1 220 1 PHE Y 178  ILE Y 183  0                                        
SHEET    1 221 1 THR Z   3  PHE Z   8  0                                        
SHEET    1 222 1 GLY Z  11  ALA Z  16  0                                        
SHEET    1 223 1 ALA Z  20  ALA Z  22  0                                        
SHEET    1 224 1 TYR Z  25  SER Z  28  0                                        
SHEET    1 225 1 MET Z 100  TRP Z 104  0                                        
SHEET    1 226 1 PRO Z 109  ASP Z 115  0                                        
SHEET    1 227 1 GLY Z 118  ILE Z 121  0                                        
SHEET    1 228 1 LEU Z 176  ARG Z 180  0                                        
SHEET    1 229 1 GLY Z 183  SER Z 188  0                                        
SHEET    1 230 1 THR a  11  ILE a  15  0                                        
SHEET    1 231 1 ALA a  21  ASP a  26  0                                        
SHEET    1 232 1 LEU a  29  GLU a  31  0                                        
SHEET    1 233 1 SER a  34  THR a  37  0                                        
SHEET    1 234 1 CYS a  43  LYS a  45  0                                        
SHEET    1 235 1 VAL a  51  SER a  55  0                                        
SHEET    1 236 1 TYR a 107  GLY a 111  0                                        
SHEET    1 237 1 PHE a 135  GLY a 138  0                                        
SHEET    1 238 1 LEU a 193  THR a 199  0                                        
SHEET    1 239 1 GLY a 202  ARG a 204  0                                        
SHEET    1 240 1 LEU b  12  PHE b  16  0                                        
SHEET    1 241 1 GLY b  19  ALA b  24  0                                        
SHEET    1 242 1 ILE b  42  ASN b  46  0                                        
SHEET    1 243 1 THR b  49  SER b  54  0                                        
SHEET    1 244 1 THR b 109  ALA b 116  0                                        
SHEET    1 245 1 GLU b 119  ASP b 126  0                                        
SHEET    1 246 1 GLY b 129  GLU b 133  0                                        
SHEET    1 247 1 SER b 136  ALA b 138  0                                        
SHEET    1 248 1 GLN b 188  VAL b 192  0                                        
SSBOND   1 CYS M   54    CYS M   61                          1555   1555  2.01  
SSBOND   2 CYS a   54    CYS a   61                          1555   1555  2.01  
LINK         OG1 THR H   1                 C21 KNM H 300     1555   1555  1.43  
LINK         OG1 THR I   1                 C21 KNM I 300     1555   1555  1.43  
LINK         OG1 THR L   1                 C21 KNM L 300     1555   1555  1.42  
LINK         OG1 THR V   1                 C21 KNM V 300     1555   1555  1.43  
LINK         OG1 THR W   1                 C21 KNM W 300     1555   1555  1.43  
LINK         OG1 THR Z   1                 C21 KNM Z 300     1555   1555  1.42  
SITE     1 AC1 11 THR H   1  THR H  20  THR H  21  THR H  22                    
SITE     2 AC1 11 LYS H  33  ARG H  45  GLY H  47  SER H  48                    
SITE     3 AC1 11 SER H 130  HIS I 116  SER I 118                               
SITE     1 AC2 11 THR I   1  ALA I  20  THR I  21  GLU I  22                    
SITE     2 AC2 11 ALA I  46  GLY I  47  ALA I  49  THR I  52                    
SITE     3 AC2 11 GLY I 128  SER I 129  ASP J 124                               
SITE     1 AC3  9 THR L   1  ALA L  20  THR L  21  ALA L  22                    
SITE     2 AC3  9 LYS L  33  MET L  45  GLY L  47  ALA L  49                    
SITE     3 AC3  9 ASP M 125                                                     
SITE     1 AC4 11 THR V   1  THR V  20  THR V  21  THR V  22                    
SITE     2 AC4 11 LYS V  33  ARG V  45  GLY V  47  SER V  48                    
SITE     3 AC4 11 SER V 130  HIS W 116  SER W 118                               
SITE     1 AC5 11 THR W   1  ALA W  20  THR W  21  GLU W  22                    
SITE     2 AC5 11 ALA W  46  GLY W  47  ALA W  49  THR W  52                    
SITE     3 AC5 11 GLY W 128  SER W 129  ASP X 124                               
SITE     1 AC6  9 THR Z   1  ALA Z  20  THR Z  21  ALA Z  22                    
SITE     2 AC6  9 LYS Z  33  MET Z  45  GLY Z  47  ALA Z  49                    
SITE     3 AC6  9 ASP a 125                                                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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