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Database: PDB
Entry: 5EZV
LinkDB: 5EZV
Original site: 5EZV 
HEADER    TRANSFERASE                             26-NOV-15   5EZV              
TITLE     X-RAY CRYSTAL STRUCTURE OF AMP-ACTIVATED PROTEIN KINASE ALPHA-2/ALPHA-
TITLE    2 1 RIM CHIMAERA (ALPHA-2(1-347)/ALPHA-1(349-401)/ALPHA-2(397-END)     
TITLE    3 BETA-1 GAMMA-1) CO-CRYSTALLIZED WITH C2 (5-(5-HYDROXYL-ISOXAZOL-3-   
TITLE    4 YL)-FURAN-2-PHOSPHONIC ACID)                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-   
COMPND   3 2/ALPHA-1 RIM SWAP CHIMERA;                                          
COMPND   4 CHAIN: A, C;                                                         
COMPND   5 SYNONYM: AMPK SUBUNIT ALPHA-2,ACETYL-COA CARBOXYLASE KINASE,ACACA    
COMPND   6 KINASE,HYDROXYMETHYLGLUTARYL-COA REDUCTASE KINASE,HMGCR KINASE,AMPK  
COMPND   7 SUBUNIT ALPHA-1,ACETYL-COA CARBOXYLASE KINASE,ACACA KINASE,          
COMPND   8 HYDROXYMETHYLGLUTARYL-COA REDUCTASE KINASE,HMGCR KINASE,TAU-PROTEIN  
COMPND   9 KINASE PRKAA1;                                                       
COMPND  10 EC: 2.7.11.1,2.7.11.27,2.7.11.31;                                    
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 2;                                                           
COMPND  13 MOLECULE: 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1;            
COMPND  14 CHAIN: B, D;                                                         
COMPND  15 SYNONYM: AMPKB;                                                      
COMPND  16 ENGINEERED: YES;                                                     
COMPND  17 MOL_ID: 3;                                                           
COMPND  18 MOLECULE: 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1;           
COMPND  19 CHAIN: E, F;                                                         
COMPND  20 SYNONYM: AMPKG;                                                      
COMPND  21 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: PRKAA2, AMPK, AMPK2, PRKAA1, AMPK1;                            
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: ROSETTA 2 (DE3);                           
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PETDUET-1;                                
SOURCE  11 MOL_ID: 2;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  13 ORGANISM_COMMON: HUMAN;                                              
SOURCE  14 ORGANISM_TAXID: 9606;                                                
SOURCE  15 GENE: PRKAB1, AMPK;                                                  
SOURCE  16 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  17 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  18 EXPRESSION_SYSTEM_STRAIN: ROSETTA 2 (DE3);                           
SOURCE  19 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  20 EXPRESSION_SYSTEM_PLASMID: PCOLA;                                    
SOURCE  21 MOL_ID: 3;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  23 ORGANISM_COMMON: HUMAN;                                              
SOURCE  24 ORGANISM_TAXID: 9606;                                                
SOURCE  25 GENE: PRKAG1;                                                        
SOURCE  26 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  27 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  28 EXPRESSION_SYSTEM_STRAIN: ROSETTA 2 (DE3);                           
SOURCE  29 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  30 EXPRESSION_SYSTEM_PLASMID: PETDUET-1                                 
KEYWDS    TRANSFERASE, SERINE/THREONINE KINASE, ALLOSTERIC ACTIVATION,          
KEYWDS   2 NUCLEOTIDE-BINDING                                                   
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    C.G.LANGENDORF,B.E.KEMP                                               
REVDAT   2   23-MAR-16 5EZV    1       JRNL                                     
REVDAT   1   09-MAR-16 5EZV    0                                                
JRNL        AUTH   C.G.LANGENDORF,K.R.NGOEI,J.W.SCOTT,N.X.LING,S.M.ISSA,        
JRNL        AUTH 2 M.A.GORMAN,M.W.PARKER,K.SAKAMOTO,J.S.OAKHILL,B.E.KEMP        
JRNL        TITL   STRUCTURAL BASIS OF ALLOSTERIC AND SYNERGISTIC ACTIVATION OF 
JRNL        TITL 2 AMPK BY FURAN-2-PHOSPHONIC DERIVATIVE C2 BINDING.            
JRNL        REF    NAT COMMUN                    V.   7 10912 2016              
JRNL        REFN                   ESSN 2041-1723                               
JRNL        PMID   26952388                                                     
JRNL        DOI    10.1038/NCOMMS10912                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.99 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : BUSTER-TNT 1.10.0                                    
REMARK   3   AUTHORS     : BRICOGNE,BLANC,BRANDL,FLENSBURG,KELLER,              
REMARK   3               : PACIOREK,ROVERSI,SMART,VONRHEIN,WOMACK,              
REMARK   3               : MATTHEWS,TEN EYCK,TRONRUD                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.99                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 49.30                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.3                           
REMARK   3   NUMBER OF REFLECTIONS             : 56562                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD           : THROUGHOUT                     
REMARK   3   FREE R VALUE TEST SET SELECTION   : RANDOM                         
REMARK   3   R VALUE     (WORKING + TEST SET)  : 0.225                          
REMARK   3   R VALUE            (WORKING SET)  : 0.224                          
REMARK   3   FREE R VALUE                      : 0.245                          
REMARK   3   FREE R VALUE TEST SET SIZE   (%)  : 5.070                          
REMARK   3   FREE R VALUE TEST SET COUNT       : 2867                           
REMARK   3   ESTIMATED ERROR OF FREE R VALUE   : NULL                           
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED               : 20                       
REMARK   3   BIN RESOLUTION RANGE HIGH   (ANGSTROMS) : 2.99                     
REMARK   3   BIN RESOLUTION RANGE LOW    (ANGSTROMS) : 3.07                     
REMARK   3   BIN COMPLETENESS (WORKING+TEST)     (%) : 99.30                    
REMARK   3   REFLECTIONS IN BIN (WORKING + TEST SET) : 4109                     
REMARK   3   BIN R VALUE        (WORKING + TEST SET) : 0.2734                   
REMARK   3   REFLECTIONS IN BIN        (WORKING SET) : 3913                     
REMARK   3   BIN R VALUE               (WORKING SET) : 0.2731                   
REMARK   3   BIN FREE R VALUE                        : 0.2795                   
REMARK   3   BIN FREE R VALUE TEST SET SIZE      (%) : 4.77                     
REMARK   3   BIN FREE R VALUE TEST SET COUNT         : 196                      
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE     : NULL                     
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 14408                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 182                                     
REMARK   3   SOLVENT ATOMS            : 84                                      
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 87.43                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 68.78                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 2.01600                                              
REMARK   3    B22 (A**2) : -8.75120                                             
REMARK   3    B33 (A**2) : 6.73520                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : -3.03480                                             
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT                    (A) : 0.480               
REMARK   3   DPI (BLOW EQ-10) BASED ON R VALUE        (A) : 4.496               
REMARK   3   DPI (BLOW EQ-9) BASED ON FREE R VALUE    (A) : 0.359               
REMARK   3   DPI (CRUICKSHANK) BASED ON R VALUE       (A) : NULL                
REMARK   3   DPI (CRUICKSHANK) BASED ON FREE R VALUE  (A) : NULL                
REMARK   3                                                                      
REMARK   3   REFERENCES: BLOW, D. (2002) ACTA CRYST D58, 792-797                
REMARK   3               CRUICKSHANK, D.W.J. (1999) ACTA CRYST D55, 583-601     
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.907                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.893                         
REMARK   3                                                                      
REMARK   3   NUMBER OF GEOMETRIC FUNCTION TERMS DEFINED : 15                    
REMARK   3   TERM                          COUNT    WEIGHT   FUNCTION.          
REMARK   3    BOND LENGTHS              : 14989  ; 2.000  ; HARMONIC            
REMARK   3    BOND ANGLES               : 20434  ; 2.000  ; HARMONIC            
REMARK   3    TORSION ANGLES            : 4985   ; 2.000  ; SINUSOIDAL          
REMARK   3    TRIGONAL CARBON PLANES    : 295    ; 2.000  ; HARMONIC            
REMARK   3    GENERAL PLANES            : 2179   ; 5.000  ; HARMONIC            
REMARK   3    ISOTROPIC THERMAL FACTORS : 14989  ; 20.000 ; HARMONIC            
REMARK   3    BAD NON-BONDED CONTACTS   : NULL   ; NULL   ; NULL                
REMARK   3    IMPROPER TORSIONS         : NULL   ; NULL   ; NULL                
REMARK   3    PSEUDOROTATION ANGLES     : NULL   ; NULL   ; NULL                
REMARK   3    CHIRAL IMPROPER TORSION   : 1979   ; 5.000  ; SEMIHARMONIC        
REMARK   3    SUM OF OCCUPANCIES        : NULL   ; NULL   ; NULL                
REMARK   3    UTILITY DISTANCES         : NULL   ; NULL   ; NULL                
REMARK   3    UTILITY ANGLES            : NULL   ; NULL   ; NULL                
REMARK   3    UTILITY TORSION           : NULL   ; NULL   ; NULL                
REMARK   3    IDEAL-DIST CONTACT TERM   : 16268  ; 4.000  ; SEMIHARMONIC        
REMARK   3                                                                      
REMARK   3   RMS DEVIATIONS FROM IDEAL VALUES.                                  
REMARK   3    BOND LENGTHS                       (A) : 0.008                    
REMARK   3    BOND ANGLES                  (DEGREES) : 0.98                     
REMARK   3    PEPTIDE OMEGA TORSION ANGLES (DEGREES) : 1.54                     
REMARK   3    OTHER TORSION ANGLES         (DEGREES) : 17.91                    
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 1                                          
REMARK   3                                                                      
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: { *|* }                                                
REMARK   3    ORIGIN FOR THE GROUP (A):  119.3968  -35.0872   35.6237           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.4060 T22:    0.3918                                    
REMARK   3     T33:    0.3920 T12:   -0.0745                                    
REMARK   3     T13:    0.0325 T23:   -0.0152                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    0.1111 L22:    0.2970                                    
REMARK   3     L33:    0.0977 L12:   -0.1907                                    
REMARK   3     L13:    0.1086 L23:   -0.1722                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0061 S12:    0.0191 S13:    0.0330                     
REMARK   3     S21:    0.0155 S22:    0.0096 S23:    0.0250                     
REMARK   3     S31:    0.0165 S32:   -0.0540 S33:   -0.0157                     
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 5EZV COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 30-NOV-15.                  
REMARK 100 THE DEPOSITION ID IS D_1000215591.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 06-FEB-15                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 6.2                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : AUSTRALIAN SYNCHROTRON             
REMARK 200  BEAMLINE                       : MX2                                
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9537                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : MIRRORS                            
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R                  
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS 0.1.27                     
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 56584                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.990                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 49.300                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.4                               
REMARK 200  DATA REDUNDANCY                : 3.200                              
REMARK 200  R MERGE                    (I) : 0.08100                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 10.1000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.99                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.08                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 98.0                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.20                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.46800                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.600                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER 6.3.0                                          
REMARK 200 STARTING MODEL: 4ZHX                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 54.38                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.70                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 8 % PEG 3350, 0.1 M MGCL2, 1.0 %         
REMARK 280  GLUCOSE, 0.001 % COCAMIDOPROPYL BETAINE, 0.1 M IMIDAZOLE, PH 6.2,   
REMARK 280  VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K                     
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y+1/2,-Z                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       67.05600            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 13800 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 41600 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -85.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, E                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 14060 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 41800 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -88.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D, F                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -13                                                      
REMARK 465     GLY A   -12                                                      
REMARK 465     SER A   -11                                                      
REMARK 465     SER A   -10                                                      
REMARK 465     HIS A    -9                                                      
REMARK 465     HIS A    -8                                                      
REMARK 465     HIS A    -7                                                      
REMARK 465     HIS A    -6                                                      
REMARK 465     HIS A    -5                                                      
REMARK 465     HIS A    -4                                                      
REMARK 465     HIS A    -3                                                      
REMARK 465     SER A    -2                                                      
REMARK 465     GLN A    -1                                                      
REMARK 465     ASP A     0                                                      
REMARK 465     PRO A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     GLU A     3                                                      
REMARK 465     LYS A     4                                                      
REMARK 465     GLN A     5                                                      
REMARK 465     LYS A     6                                                      
REMARK 465     HIS A     7                                                      
REMARK 465     SER A   345                                                      
REMARK 465     PRO A   346                                                      
REMARK 465     PRO A   347                                                      
REMARK 465     ASP A   348                                                      
REMARK 465     SER A   349                                                      
REMARK 465     PHE A   350                                                      
REMARK 465     LEU A   351                                                      
REMARK 465     ASP A   352                                                      
REMARK 465     ASP A   353                                                      
REMARK 465     HIS A   354                                                      
REMARK 465     HIS A   355                                                      
REMARK 465     LEU A   356                                                      
REMARK 465     THR A   357                                                      
REMARK 465     LEU A   367                                                      
REMARK 465     VAL A   368                                                      
REMARK 465     ALA A   369                                                      
REMARK 465     GLU A   370                                                      
REMARK 465     THR A   371                                                      
REMARK 465     PRO A   372                                                      
REMARK 465     ARG A   373                                                      
REMARK 465     ALA A   374                                                      
REMARK 465     ARG A   375                                                      
REMARK 465     HIS A   376                                                      
REMARK 465     THR A   377                                                      
REMARK 465     LEU A   378                                                      
REMARK 465     ASP A   379                                                      
REMARK 465     GLU A   380                                                      
REMARK 465     LEU A   381                                                      
REMARK 465     ASN A   382                                                      
REMARK 465     PRO A   383                                                      
REMARK 465     GLN A   384                                                      
REMARK 465     LYS A   385                                                      
REMARK 465     SER A   386                                                      
REMARK 465     LYS A   387                                                      
REMARK 465     HIS A   388                                                      
REMARK 465     GLN A   389                                                      
REMARK 465     GLY A   390                                                      
REMARK 465     VAL A   391                                                      
REMARK 465     LYS A   392                                                      
REMARK 465     GLU A   469                                                      
REMARK 465     VAL A   470                                                      
REMARK 465     VAL A   471                                                      
REMARK 465     GLU A   472                                                      
REMARK 465     GLN A   473                                                      
REMARK 465     ARG A   474                                                      
REMARK 465     SER A   475                                                      
REMARK 465     GLY A   476                                                      
REMARK 465     SER A   477                                                      
REMARK 465     SER A   478                                                      
REMARK 465     THR A   479                                                      
REMARK 465     PRO A   480                                                      
REMARK 465     GLN A   481                                                      
REMARK 465     ARG A   482                                                      
REMARK 465     SER A   483                                                      
REMARK 465     CYS A   484                                                      
REMARK 465     SER A   485                                                      
REMARK 465     ALA A   486                                                      
REMARK 465     ALA A   487                                                      
REMARK 465     GLY A   488                                                      
REMARK 465     LEU A   489                                                      
REMARK 465     HIS A   490                                                      
REMARK 465     ARG A   491                                                      
REMARK 465     PRO A   492                                                      
REMARK 465     ARG A   493                                                      
REMARK 465     SER A   494                                                      
REMARK 465     SER A   495                                                      
REMARK 465     PHE A   496                                                      
REMARK 465     ASP A   497                                                      
REMARK 465     SER A   498                                                      
REMARK 465     THR A   499                                                      
REMARK 465     THR A   500                                                      
REMARK 465     ALA A   501                                                      
REMARK 465     GLU A   502                                                      
REMARK 465     SER A   503                                                      
REMARK 465     HIS A   504                                                      
REMARK 465     SER A   505                                                      
REMARK 465     LEU A   506                                                      
REMARK 465     SER A   507                                                      
REMARK 465     GLY A   508                                                      
REMARK 465     SER A   509                                                      
REMARK 465     LEU A   510                                                      
REMARK 465     THR A   511                                                      
REMARK 465     GLY A   512                                                      
REMARK 465     SER A   513                                                      
REMARK 465     LEU A   514                                                      
REMARK 465     THR A   515                                                      
REMARK 465     GLY A   516                                                      
REMARK 465     SER A   517                                                      
REMARK 465     THR A   518                                                      
REMARK 465     LEU A   519                                                      
REMARK 465     SER A   520                                                      
REMARK 465     SER A   521                                                      
REMARK 465     VAL A   522                                                      
REMARK 465     SER A   523                                                      
REMARK 465     PRO A   524                                                      
REMARK 465     ARG A   525                                                      
REMARK 465     ARG A   546                                                      
REMARK 465     MET B     1                                                      
REMARK 465     GLY B     2                                                      
REMARK 465     ASN B     3                                                      
REMARK 465     THR B     4                                                      
REMARK 465     SER B     5                                                      
REMARK 465     SER B     6                                                      
REMARK 465     GLU B     7                                                      
REMARK 465     ARG B     8                                                      
REMARK 465     ALA B     9                                                      
REMARK 465     ALA B    10                                                      
REMARK 465     LEU B    11                                                      
REMARK 465     GLU B    12                                                      
REMARK 465     ARG B    13                                                      
REMARK 465     HIS B    14                                                      
REMARK 465     GLY B    15                                                      
REMARK 465     GLY B    16                                                      
REMARK 465     HIS B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     THR B    19                                                      
REMARK 465     PRO B    20                                                      
REMARK 465     ARG B    21                                                      
REMARK 465     ARG B    22                                                      
REMARK 465     ASP B    23                                                      
REMARK 465     SER B    24                                                      
REMARK 465     SER B    25                                                      
REMARK 465     GLY B    26                                                      
REMARK 465     GLY B    27                                                      
REMARK 465     THR B    28                                                      
REMARK 465     LYS B    29                                                      
REMARK 465     ASP B    30                                                      
REMARK 465     GLY B    31                                                      
REMARK 465     ASP B    32                                                      
REMARK 465     ARG B    33                                                      
REMARK 465     PRO B    34                                                      
REMARK 465     LYS B    35                                                      
REMARK 465     ILE B    36                                                      
REMARK 465     LEU B    37                                                      
REMARK 465     MET B    38                                                      
REMARK 465     ASP B    39                                                      
REMARK 465     SER B    40                                                      
REMARK 465     PRO B    41                                                      
REMARK 465     GLU B    42                                                      
REMARK 465     ASP B    43                                                      
REMARK 465     ALA B    44                                                      
REMARK 465     ASP B    45                                                      
REMARK 465     LEU B    46                                                      
REMARK 465     PHE B    47                                                      
REMARK 465     HIS B    48                                                      
REMARK 465     SER B    49                                                      
REMARK 465     GLU B    50                                                      
REMARK 465     GLU B    51                                                      
REMARK 465     ILE B    52                                                      
REMARK 465     LYS B    53                                                      
REMARK 465     ALA B    54                                                      
REMARK 465     PRO B    55                                                      
REMARK 465     GLU B    56                                                      
REMARK 465     LYS B    57                                                      
REMARK 465     GLU B    58                                                      
REMARK 465     GLU B    59                                                      
REMARK 465     PHE B    60                                                      
REMARK 465     LEU B    61                                                      
REMARK 465     ALA B    62                                                      
REMARK 465     TRP B    63                                                      
REMARK 465     GLN B    64                                                      
REMARK 465     HIS B    65                                                      
REMARK 465     ASP B    66                                                      
REMARK 465     LEU B    67                                                      
REMARK 465     GLU B    68                                                      
REMARK 465     VAL B    69                                                      
REMARK 465     ASN B    70                                                      
REMARK 465     ASP B    71                                                      
REMARK 465     LYS B    72                                                      
REMARK 465     ALA B    73                                                      
REMARK 465     PRO B    74                                                      
REMARK 465     ALA B    75                                                      
REMARK 465     GLN B    76                                                      
REMARK 465     ALA B    77                                                      
REMARK 465     SER B   177                                                      
REMARK 465     GLU B   178                                                      
REMARK 465     LEU B   179                                                      
REMARK 465     SER B   180                                                      
REMARK 465     SER B   181                                                      
REMARK 465     SER B   182                                                      
REMARK 465     PRO B   183                                                      
REMARK 465     PRO B   184                                                      
REMARK 465     MET C   -13                                                      
REMARK 465     GLY C   -12                                                      
REMARK 465     SER C   -11                                                      
REMARK 465     SER C   -10                                                      
REMARK 465     HIS C    -9                                                      
REMARK 465     HIS C    -8                                                      
REMARK 465     HIS C    -7                                                      
REMARK 465     HIS C    -6                                                      
REMARK 465     HIS C    -5                                                      
REMARK 465     HIS C    -4                                                      
REMARK 465     HIS C    -3                                                      
REMARK 465     SER C    -2                                                      
REMARK 465     GLN C    -1                                                      
REMARK 465     ASP C     0                                                      
REMARK 465     PRO C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     GLU C     3                                                      
REMARK 465     LYS C     4                                                      
REMARK 465     GLN C     5                                                      
REMARK 465     LYS C     6                                                      
REMARK 465     HIS C     7                                                      
REMARK 465     ASP C     8                                                      
REMARK 465     GLN C   317                                                      
REMARK 465     ASP C   318                                                      
REMARK 465     PRO C   346                                                      
REMARK 465     PRO C   347                                                      
REMARK 465     ASP C   348                                                      
REMARK 465     SER C   349                                                      
REMARK 465     PHE C   350                                                      
REMARK 465     LEU C   351                                                      
REMARK 465     ASP C   352                                                      
REMARK 465     ASP C   353                                                      
REMARK 465     HIS C   354                                                      
REMARK 465     HIS C   355                                                      
REMARK 465     LEU C   356                                                      
REMARK 465     THR C   357                                                      
REMARK 465     PRO C   365                                                      
REMARK 465     PHE C   366                                                      
REMARK 465     LEU C   367                                                      
REMARK 465     VAL C   368                                                      
REMARK 465     ALA C   369                                                      
REMARK 465     GLU C   370                                                      
REMARK 465     THR C   371                                                      
REMARK 465     PRO C   372                                                      
REMARK 465     ARG C   373                                                      
REMARK 465     ALA C   374                                                      
REMARK 465     ARG C   375                                                      
REMARK 465     HIS C   376                                                      
REMARK 465     THR C   377                                                      
REMARK 465     LEU C   378                                                      
REMARK 465     ASP C   379                                                      
REMARK 465     GLU C   380                                                      
REMARK 465     LEU C   381                                                      
REMARK 465     ASN C   382                                                      
REMARK 465     PRO C   383                                                      
REMARK 465     GLN C   384                                                      
REMARK 465     LYS C   385                                                      
REMARK 465     SER C   386                                                      
REMARK 465     LYS C   387                                                      
REMARK 465     HIS C   388                                                      
REMARK 465     GLN C   389                                                      
REMARK 465     GLY C   390                                                      
REMARK 465     VAL C   391                                                      
REMARK 465     LYS C   392                                                      
REMARK 465     VAL C   470                                                      
REMARK 465     VAL C   471                                                      
REMARK 465     GLU C   472                                                      
REMARK 465     GLN C   473                                                      
REMARK 465     ARG C   474                                                      
REMARK 465     SER C   475                                                      
REMARK 465     GLY C   476                                                      
REMARK 465     SER C   477                                                      
REMARK 465     SER C   478                                                      
REMARK 465     THR C   479                                                      
REMARK 465     PRO C   480                                                      
REMARK 465     GLN C   481                                                      
REMARK 465     ARG C   482                                                      
REMARK 465     SER C   483                                                      
REMARK 465     CYS C   484                                                      
REMARK 465     SER C   485                                                      
REMARK 465     ALA C   486                                                      
REMARK 465     ALA C   487                                                      
REMARK 465     GLY C   488                                                      
REMARK 465     LEU C   489                                                      
REMARK 465     HIS C   490                                                      
REMARK 465     ARG C   491                                                      
REMARK 465     PRO C   492                                                      
REMARK 465     ARG C   493                                                      
REMARK 465     SER C   494                                                      
REMARK 465     SER C   495                                                      
REMARK 465     PHE C   496                                                      
REMARK 465     ASP C   497                                                      
REMARK 465     SER C   498                                                      
REMARK 465     THR C   499                                                      
REMARK 465     THR C   500                                                      
REMARK 465     ALA C   501                                                      
REMARK 465     GLU C   502                                                      
REMARK 465     SER C   503                                                      
REMARK 465     HIS C   504                                                      
REMARK 465     SER C   505                                                      
REMARK 465     LEU C   506                                                      
REMARK 465     SER C   507                                                      
REMARK 465     GLY C   508                                                      
REMARK 465     SER C   509                                                      
REMARK 465     LEU C   510                                                      
REMARK 465     THR C   511                                                      
REMARK 465     GLY C   512                                                      
REMARK 465     SER C   513                                                      
REMARK 465     LEU C   514                                                      
REMARK 465     THR C   515                                                      
REMARK 465     GLY C   516                                                      
REMARK 465     SER C   517                                                      
REMARK 465     THR C   518                                                      
REMARK 465     LEU C   519                                                      
REMARK 465     SER C   520                                                      
REMARK 465     SER C   521                                                      
REMARK 465     VAL C   522                                                      
REMARK 465     SER C   523                                                      
REMARK 465     ARG C   546                                                      
REMARK 465     MET D     1                                                      
REMARK 465     GLY D     2                                                      
REMARK 465     ASN D     3                                                      
REMARK 465     THR D     4                                                      
REMARK 465     SER D     5                                                      
REMARK 465     SER D     6                                                      
REMARK 465     GLU D     7                                                      
REMARK 465     ARG D     8                                                      
REMARK 465     ALA D     9                                                      
REMARK 465     ALA D    10                                                      
REMARK 465     LEU D    11                                                      
REMARK 465     GLU D    12                                                      
REMARK 465     ARG D    13                                                      
REMARK 465     HIS D    14                                                      
REMARK 465     GLY D    15                                                      
REMARK 465     GLY D    16                                                      
REMARK 465     HIS D    17                                                      
REMARK 465     LYS D    18                                                      
REMARK 465     THR D    19                                                      
REMARK 465     PRO D    20                                                      
REMARK 465     ARG D    21                                                      
REMARK 465     ARG D    22                                                      
REMARK 465     ASP D    23                                                      
REMARK 465     SER D    24                                                      
REMARK 465     SER D    25                                                      
REMARK 465     GLY D    26                                                      
REMARK 465     GLY D    27                                                      
REMARK 465     THR D    28                                                      
REMARK 465     LYS D    29                                                      
REMARK 465     ASP D    30                                                      
REMARK 465     GLY D    31                                                      
REMARK 465     ASP D    32                                                      
REMARK 465     ARG D    33                                                      
REMARK 465     PRO D    34                                                      
REMARK 465     LYS D    35                                                      
REMARK 465     ILE D    36                                                      
REMARK 465     LEU D    37                                                      
REMARK 465     MET D    38                                                      
REMARK 465     ASP D    39                                                      
REMARK 465     SER D    40                                                      
REMARK 465     PRO D    41                                                      
REMARK 465     GLU D    42                                                      
REMARK 465     ASP D    43                                                      
REMARK 465     ALA D    44                                                      
REMARK 465     ASP D    45                                                      
REMARK 465     LEU D    46                                                      
REMARK 465     PHE D    47                                                      
REMARK 465     HIS D    48                                                      
REMARK 465     SER D    49                                                      
REMARK 465     GLU D    50                                                      
REMARK 465     GLU D    51                                                      
REMARK 465     ILE D    52                                                      
REMARK 465     LYS D    53                                                      
REMARK 465     ALA D    54                                                      
REMARK 465     PRO D    55                                                      
REMARK 465     GLU D    56                                                      
REMARK 465     LYS D    57                                                      
REMARK 465     GLU D    58                                                      
REMARK 465     GLU D    59                                                      
REMARK 465     PHE D    60                                                      
REMARK 465     LEU D    61                                                      
REMARK 465     ALA D    62                                                      
REMARK 465     TRP D    63                                                      
REMARK 465     GLN D    64                                                      
REMARK 465     HIS D    65                                                      
REMARK 465     ASP D    66                                                      
REMARK 465     LEU D    67                                                      
REMARK 465     GLU D    68                                                      
REMARK 465     VAL D    69                                                      
REMARK 465     ASN D    70                                                      
REMARK 465     ASP D    71                                                      
REMARK 465     LYS D    72                                                      
REMARK 465     ALA D    73                                                      
REMARK 465     PRO D    74                                                      
REMARK 465     ALA D    75                                                      
REMARK 465     GLN D    76                                                      
REMARK 465     SER D   180                                                      
REMARK 465     SER D   181                                                      
REMARK 465     SER D   182                                                      
REMARK 465     PRO D   183                                                      
REMARK 465     PRO D   184                                                      
REMARK 465     GLY D   185                                                      
REMARK 465     PRO D   196                                                      
REMARK 465     ILE D   270                                                      
REMARK 465     MET E    -4                                                      
REMARK 465     ALA E    -3                                                      
REMARK 465     ASP E    -2                                                      
REMARK 465     LEU E    -1                                                      
REMARK 465     ASN E     0                                                      
REMARK 465     TRP E     1                                                      
REMARK 465     GLU E     2                                                      
REMARK 465     THR E     3                                                      
REMARK 465     VAL E     4                                                      
REMARK 465     ILE E     5                                                      
REMARK 465     SER E     6                                                      
REMARK 465     SER E     7                                                      
REMARK 465     ASP E     8                                                      
REMARK 465     SER E     9                                                      
REMARK 465     SER E    10                                                      
REMARK 465     PRO E    11                                                      
REMARK 465     ALA E    12                                                      
REMARK 465     VAL E    13                                                      
REMARK 465     GLU E    14                                                      
REMARK 465     ASN E    15                                                      
REMARK 465     GLU E    16                                                      
REMARK 465     HIS E    17                                                      
REMARK 465     PRO E    18                                                      
REMARK 465     GLN E    19                                                      
REMARK 465     GLU E    20                                                      
REMARK 465     THR E    21                                                      
REMARK 465     PRO E    22                                                      
REMARK 465     GLU E    23                                                      
REMARK 465     ASP E   124                                                      
REMARK 465     GLY E   327                                                      
REMARK 465     GLU E   328                                                      
REMARK 465     LYS E   329                                                      
REMARK 465     LYS E   330                                                      
REMARK 465     PRO E   331                                                      
REMARK 465     MET F    -4                                                      
REMARK 465     ALA F    -3                                                      
REMARK 465     ASP F    -2                                                      
REMARK 465     LEU F    -1                                                      
REMARK 465     ASN F     0                                                      
REMARK 465     TRP F     1                                                      
REMARK 465     GLU F     2                                                      
REMARK 465     THR F     3                                                      
REMARK 465     VAL F     4                                                      
REMARK 465     ILE F     5                                                      
REMARK 465     SER F     6                                                      
REMARK 465     SER F     7                                                      
REMARK 465     ASP F     8                                                      
REMARK 465     SER F     9                                                      
REMARK 465     SER F    10                                                      
REMARK 465     PRO F    11                                                      
REMARK 465     ALA F    12                                                      
REMARK 465     VAL F    13                                                      
REMARK 465     GLU F    14                                                      
REMARK 465     ASN F    15                                                      
REMARK 465     GLU F    16                                                      
REMARK 465     HIS F    17                                                      
REMARK 465     PRO F    18                                                      
REMARK 465     GLN F    19                                                      
REMARK 465     GLU F    20                                                      
REMARK 465     THR F    21                                                      
REMARK 465     PRO F    22                                                      
REMARK 465     GLU F    23                                                      
REMARK 465     SER F    24                                                      
REMARK 465     THR F   325                                                      
REMARK 465     GLY F   326                                                      
REMARK 465     GLY F   327                                                      
REMARK 465     GLU F   328                                                      
REMARK 465     LYS F   329                                                      
REMARK 465     LYS F   330                                                      
REMARK 465     PRO F   331                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A  12    CG   CD   CE   NZ                                   
REMARK 470     LYS A  51    CD   CE   NZ                                        
REMARK 470     VAL A  58    CG1  CG2                                            
REMARK 470     LYS A  62    CD   CE   NZ                                        
REMARK 470     GLU A 112    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 224    CE   NZ                                             
REMARK 470     LYS A 225    CG   CD   CE   NZ                                   
REMARK 470     ARG A 239    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 260    CG   CD   CE   NZ                                   
REMARK 470     GLU A 291    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 294    CG   CD   CE   NZ                                   
REMARK 470     LYS A 299    CD   CE   NZ                                        
REMARK 470     GLU A 304    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 309    CG   OD1  ND2                                       
REMARK 470     ASP A 315    CG   OD1  OD2                                       
REMARK 470     GLN A 317    CG   CD   OE1  NE2                                  
REMARK 470     ARG A 332    CZ   NH1  NH2                                       
REMARK 470     ARG A 358    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO A 359    CG   CD                                             
REMARK 470     VAL A 364    CG1  CG2                                            
REMARK 470     PRO A 365    CG   CD                                             
REMARK 470     PHE A 366    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS A 393    CG   CD   CE   NZ                                   
REMARK 470     LYS A 405    CE   NZ                                             
REMARK 470     TYR A 407    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ARG A 415    NE   CZ   NH1  NH2                                  
REMARK 470     LYS A 418    CG   CD   CE   NZ                                   
REMARK 470     GLU A 423    CD   OE1  OE2                                       
REMARK 470     VAL A 426    CG1  CG2                                            
REMARK 470     LYS A 437    CE   NZ                                             
REMARK 470     ARG A 457    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP A 468    CG   OD1  OD2                                       
REMARK 470     LEU A 526    CG   CD1  CD2                                       
REMARK 470     LEU A 544    CG   CD1  CD2                                       
REMARK 470     ARG B  78    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B  89    CG   CD   CE   NZ                                   
REMARK 470     ASN B  99    CG   OD1  ND2                                       
REMARK 470     ASP B 117    CG   OD1  OD2                                       
REMARK 470     GLU B 122    CG   CD   OE1  OE2                                  
REMARK 470     GLN B 132    CG   CD   OE1  NE2                                  
REMARK 470     LYS B 157    CG   CD   CE   NZ                                   
REMARK 470     PHE B 160    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     MET B 167    SD   CE                                             
REMARK 470     LYS B 172    CG   CD   CE   NZ                                   
REMARK 470     GLN B 189    CG   CD   OE1  NE2                                  
REMARK 470     GLU B 190    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 195    CG   CD   CE   NZ                                   
REMARK 470     GLU B 197    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 198    CG   CD   OE1  OE2                                  
REMARK 470     ARG B 199    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE B 200    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG B 201    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE B 221    CG1  CG2  CD1                                       
REMARK 470     LYS B 245    CE   NZ                                             
REMARK 470     ASP B 246    CG   OD1  OD2                                       
REMARK 470     LYS B 259    CD   CE   NZ                                        
REMARK 470     ILE B 270    CG1  CG2  CD1                                       
REMARK 470     ARG C  10    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C  12    CG   CD   CE   NZ                                   
REMARK 470     PHE C  27    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS C  51    CE   NZ                                             
REMARK 470     ASP C  56    CG   OD1  OD2                                       
REMARK 470     LYS C  60    CE   NZ                                             
REMARK 470     LYS C  62    CE   NZ                                             
REMARK 470     ARG C 171    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 217    CG   CD   OE1  OE2                                  
REMARK 470     VAL C 219    CG1  CG2                                            
REMARK 470     LYS C 224    CG   CD   CE   NZ                                   
REMARK 470     LYS C 225    CG   CD   CE   NZ                                   
REMARK 470     LYS C 260    CG   CD   CE   NZ                                   
REMARK 470     ILE C 288    CG1  CG2  CD1                                       
REMARK 470     GLU C 291    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 294    NZ                                                  
REMARK 470     GLU C 295    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 298    CG   CD   OE1  OE2                                  
REMARK 470     PHE C 300    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU C 301    CG   CD   OE1  OE2                                  
REMARK 470     CYS C 302    SG                                                  
REMARK 470     THR C 303    OG1  CG2                                            
REMARK 470     GLU C 304    CG   CD   OE1  OE2                                  
REMARK 470     SER C 305    OG                                                  
REMARK 470     GLU C 306    CG   CD   OE1  OE2                                  
REMARK 470     GLN C 319    CG   CD   OE1  NE2                                  
REMARK 470     LEU C 320    CG   CD1  CD2                                       
REMARK 470     ARG C 358    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 393    CG   CD   CE   NZ                                   
REMARK 470     ARG C 401    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 405    CG   CD   CE   NZ                                   
REMARK 470     LYS C 418    CG   CD   CE   NZ                                   
REMARK 470     GLN C 419    CG   CD   OE1  NE2                                  
REMARK 470     LYS C 437    CG   CD   CE   NZ                                   
REMARK 470     LEU C 449    CG   CD1  CD2                                       
REMARK 470     ASN C 456    CG   OD1  ND2                                       
REMARK 470     ARG C 457    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU C 461    CG   CD1  CD2                                       
REMARK 470     ASP C 467    CG   OD1  OD2                                       
REMARK 470     GLU C 469    CG   CD   OE1  OE2                                  
REMARK 470     LEU C 540    CG   CD1  CD2                                       
REMARK 470     LEU C 544    CG   CD1  CD2                                       
REMARK 470     ARG D  78    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D  89    CG   CD   CE   NZ                                   
REMARK 470     GLU D 120    CG   CD   OE1  OE2                                  
REMARK 470     LYS D 126    CG   CD   CE   NZ                                   
REMARK 470     GLN D 132    CG   CD   OE1  NE2                                  
REMARK 470     LYS D 156    CE   NZ                                             
REMARK 470     LYS D 157    CG   CD   CE   NZ                                   
REMARK 470     LYS D 172    CD   CE   NZ                                        
REMARK 470     VAL D 176    CG1  CG2                                            
REMARK 470     LEU D 179    CG   CD1  CD2                                       
REMARK 470     GLU D 190    CG   CD   OE1  OE2                                  
REMARK 470     VAL D 193    CG1  CG2                                            
REMARK 470     LYS D 195    CG   CD   CE   NZ                                   
REMARK 470     GLU D 197    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 198    CG   CD   OE1  OE2                                  
REMARK 470     ARG D 199    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE D 200    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG D 201    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D 217    CG   CD   CE   NZ                                   
REMARK 470     LYS D 245    CD   CE   NZ                                        
REMARK 470     LEU E 122    CG   CD1  CD2                                       
REMARK 470     LYS E 127    CE   NZ                                             
REMARK 470     LYS E 177    CD   CE   NZ                                        
REMARK 470     GLU E 187    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 191    NZ                                                  
REMARK 470     GLU E 195    CD   OE1  OE2                                       
REMARK 470     ARG E 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E 233    CG   CD   OE1  OE2                                  
REMARK 470     ARG E 236    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E 264    CG   CD   CE   NZ                                   
REMARK 470     ARG E 269    NE   CZ   NH1  NH2                                  
REMARK 470     TYR E 272    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU E 274    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 294    CG   CD   OE1  OE2                                  
REMARK 470     ASP E 304    CG   OD1  OD2                                       
REMARK 470     ASP E 307    CG   OD1  OD2                                       
REMARK 470     LYS E 310    CG   CD   CE   NZ                                   
REMARK 470     LEU E 324    CG   CD1  CD2                                       
REMARK 470     ASN F  25    CG   OD1  ND2                                       
REMARK 470     ASN F  26    CG   OD1  ND2                                       
REMARK 470     TYR F 107    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU F 119    CG   CD   OE1  OE2                                  
REMARK 470     SER F 125    OG                                                  
REMARK 470     LYS F 127    CD   CE   NZ                                        
REMARK 470     GLU F 194    CG   CD   OE1  OE2                                  
REMARK 470     GLN F 197    CG   CD   OE1  NE2                                  
REMARK 470     ARG F 236    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS F 264    CG   CD   CE   NZ                                   
REMARK 470     SER F 270    OG                                                  
REMARK 470     HIS F 271    ND1  CD2  CE1  NE2                                  
REMARK 470     PHE F 273    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU F 277    CG   CD1  CD2                                       
REMARK 470     LYS F 278    CG   CD   CE   NZ                                   
REMARK 470     ASP F 304    CG   OD1  OD2                                       
REMARK 470     GLU F 305    CG   CD   OE1  OE2                                  
REMARK 470     ASN F 306    CG   OD1  ND2                                       
REMARK 470     ASP F 307    CG   OD1  OD2                                       
REMARK 470     VAL F 308    CG1  CG2                                            
REMARK 470     LYS F 310    CG   CD   CE   NZ                                   
REMARK 470     VAL F 323    CG1  CG2                                            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   CG   ASP A   166     NH2  ARG B   256              1.73            
REMARK 500   OD1  ASP A   166     NH2  ARG B   256              1.84            
REMARK 500   NH2  ARG A   138     O2P  TPO A   172              1.89            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   O    ALA C   285     OG   SER D   144     2946     2.16            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    HIS A  15       -1.27     70.30                                   
REMARK 500    ARG A 138       -4.14     63.80                                   
REMARK 500    ALA A 156      -63.06   -121.03                                   
REMARK 500    LEU A 249       68.76   -106.49                                   
REMARK 500    GLU A 279       -5.24     76.21                                   
REMARK 500    HIS B 109     -127.40     54.69                                   
REMARK 500    GLU B 197     -129.70     53.93                                   
REMARK 500    ASN B 237       -6.93     71.68                                   
REMARK 500    ARG C 138       -4.10     64.78                                   
REMARK 500    ASP C 148     -169.60   -100.13                                   
REMARK 500    ALA C 156      -67.20   -121.90                                   
REMARK 500    LEU C 249       40.69    -95.18                                   
REMARK 500    SER C 282       31.96    -95.24                                   
REMARK 500    PHE C 300     -121.05     61.55                                   
REMARK 500    GLU C 301       13.21     85.29                                   
REMARK 500    THR C 303     -130.17     59.30                                   
REMARK 500    ASP C 455     -114.64     53.19                                   
REMARK 500    ASN D 237       -5.28     68.10                                   
REMARK 500    LYS D 258     -125.82     55.13                                   
REMARK 500    LYS E 100      -50.86   -120.89                                   
REMARK 500    LEU E 122       33.49    -91.50                                   
REMARK 500    LYS F 100      -51.37   -121.75                                   
REMARK 500    LEU F 122       45.65   -108.62                                   
REMARK 500    LYS F 310      -42.12   -131.61                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue STU A 601                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue C1V A 602                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue STU C 601                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue C1V C 602                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue C2Z E 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue C2Z E 402                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue C2Z F 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue C2Z F 402                 
DBREF  5EZV A    2   347  UNP    P54646   AAPK2_HUMAN      2    347             
DBREF  5EZV A  348   390  UNP    Q13131   AAPK1_HUMAN    359    401             
DBREF  5EZV A  391   546  UNP    P54646   AAPK2_HUMAN    397    552             
DBREF  5EZV B    1   270  UNP    Q9Y478   AAKB1_HUMAN      1    270             
DBREF  5EZV C    2   347  UNP    P54646   AAPK2_HUMAN      2    347             
DBREF  5EZV C  348   390  UNP    Q13131   AAPK1_HUMAN    359    401             
DBREF  5EZV C  391   546  UNP    P54646   AAPK2_HUMAN    397    552             
DBREF  5EZV D    1   270  UNP    Q9Y478   AAKB1_HUMAN      1    270             
DBREF  5EZV E    2   331  UNP    P54619   AAKG1_HUMAN      2    331             
DBREF  5EZV F    2   331  UNP    P54619   AAKG1_HUMAN      2    331             
SEQADV 5EZV MET A  -13  UNP  P54646              INITIATING METHIONINE          
SEQADV 5EZV GLY A  -12  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV SER A  -11  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV SER A  -10  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS A   -9  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS A   -8  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS A   -7  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS A   -6  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS A   -5  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS A   -4  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS A   -3  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV SER A   -2  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV GLN A   -1  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV ASP A    0  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV PRO A    1  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV MET C  -13  UNP  P54646              INITIATING METHIONINE          
SEQADV 5EZV GLY C  -12  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV SER C  -11  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV SER C  -10  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS C   -9  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS C   -8  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS C   -7  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS C   -6  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS C   -5  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS C   -4  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV HIS C   -3  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV SER C   -2  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV GLN C   -1  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV ASP C    0  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV PRO C    1  UNP  P54646              EXPRESSION TAG                 
SEQADV 5EZV MET E   -4  UNP  P54619              INITIATING METHIONINE          
SEQADV 5EZV ALA E   -3  UNP  P54619              EXPRESSION TAG                 
SEQADV 5EZV ASP E   -2  UNP  P54619              EXPRESSION TAG                 
SEQADV 5EZV LEU E   -1  UNP  P54619              EXPRESSION TAG                 
SEQADV 5EZV ASN E    0  UNP  P54619              EXPRESSION TAG                 
SEQADV 5EZV TRP E    1  UNP  P54619              EXPRESSION TAG                 
SEQADV 5EZV MET F   -4  UNP  P54619              INITIATING METHIONINE          
SEQADV 5EZV ALA F   -3  UNP  P54619              EXPRESSION TAG                 
SEQADV 5EZV ASP F   -2  UNP  P54619              EXPRESSION TAG                 
SEQADV 5EZV LEU F   -1  UNP  P54619              EXPRESSION TAG                 
SEQADV 5EZV ASN F    0  UNP  P54619              EXPRESSION TAG                 
SEQADV 5EZV TRP F    1  UNP  P54619              EXPRESSION TAG                 
SEQRES   1 A  560  MET GLY SER SER HIS HIS HIS HIS HIS HIS HIS SER GLN          
SEQRES   2 A  560  ASP PRO ALA GLU LYS GLN LYS HIS ASP GLY ARG VAL LYS          
SEQRES   3 A  560  ILE GLY HIS TYR VAL LEU GLY ASP THR LEU GLY VAL GLY          
SEQRES   4 A  560  THR PHE GLY LYS VAL LYS ILE GLY GLU HIS GLN LEU THR          
SEQRES   5 A  560  GLY HIS LYS VAL ALA VAL LYS ILE LEU ASN ARG GLN LYS          
SEQRES   6 A  560  ILE ARG SER LEU ASP VAL VAL GLY LYS ILE LYS ARG GLU          
SEQRES   7 A  560  ILE GLN ASN LEU LYS LEU PHE ARG HIS PRO HIS ILE ILE          
SEQRES   8 A  560  LYS LEU TYR GLN VAL ILE SER THR PRO THR ASP PHE PHE          
SEQRES   9 A  560  MET VAL MET GLU TYR VAL SER GLY GLY GLU LEU PHE ASP          
SEQRES  10 A  560  TYR ILE CYS LYS HIS GLY ARG VAL GLU GLU MET GLU ALA          
SEQRES  11 A  560  ARG ARG LEU PHE GLN GLN ILE LEU SER ALA VAL ASP TYR          
SEQRES  12 A  560  CYS HIS ARG HIS MET VAL VAL HIS ARG ASP LEU LYS PRO          
SEQRES  13 A  560  GLU ASN VAL LEU LEU ASP ALA HIS MET ASN ALA LYS ILE          
SEQRES  14 A  560  ALA ASP PHE GLY LEU SER ASN MET MET SER ASP GLY GLU          
SEQRES  15 A  560  PHE LEU ARG TPO SER CYS GLY SER PRO ASN TYR ALA ALA          
SEQRES  16 A  560  PRO GLU VAL ILE SER GLY ARG LEU TYR ALA GLY PRO GLU          
SEQRES  17 A  560  VAL ASP ILE TRP SER CYS GLY VAL ILE LEU TYR ALA LEU          
SEQRES  18 A  560  LEU CYS GLY THR LEU PRO PHE ASP ASP GLU HIS VAL PRO          
SEQRES  19 A  560  THR LEU PHE LYS LYS ILE ARG GLY GLY VAL PHE TYR ILE          
SEQRES  20 A  560  PRO GLU TYR LEU ASN ARG SER VAL ALA THR LEU LEU MET          
SEQRES  21 A  560  HIS MET LEU GLN VAL ASP PRO LEU LYS ARG ALA THR ILE          
SEQRES  22 A  560  LYS ASP ILE ARG GLU HIS GLU TRP PHE LYS GLN ASP LEU          
SEQRES  23 A  560  PRO SER TYR LEU PHE PRO GLU ASP PRO SER TYR ASP ALA          
SEQRES  24 A  560  ASN VAL ILE ASP ASP GLU ALA VAL LYS GLU VAL CYS GLU          
SEQRES  25 A  560  LYS PHE GLU CYS THR GLU SER GLU VAL MET ASN SER LEU          
SEQRES  26 A  560  TYR SER GLY ASP PRO GLN ASP GLN LEU ALA VAL ALA TYR          
SEQRES  27 A  560  HIS LEU ILE ILE ASP ASN ARG ARG ILE MET ASN GLN ALA          
SEQRES  28 A  560  SER GLU PHE TYR LEU ALA SER SER PRO PRO ASP SER PHE          
SEQRES  29 A  560  LEU ASP ASP HIS HIS LEU THR ARG PRO HIS PRO GLU ARG          
SEQRES  30 A  560  VAL PRO PHE LEU VAL ALA GLU THR PRO ARG ALA ARG HIS          
SEQRES  31 A  560  THR LEU ASP GLU LEU ASN PRO GLN LYS SER LYS HIS GLN          
SEQRES  32 A  560  GLY VAL LYS LYS ALA LYS TRP HIS LEU GLY ILE ARG SER          
SEQRES  33 A  560  GLN SER LYS PRO TYR ASP ILE MET ALA GLU VAL TYR ARG          
SEQRES  34 A  560  ALA MET LYS GLN LEU ASP PHE GLU TRP LYS VAL VAL ASN          
SEQRES  35 A  560  ALA TYR HIS LEU ARG VAL ARG ARG LYS ASN PRO VAL THR          
SEQRES  36 A  560  GLY ASN TYR VAL LYS MET SER LEU GLN LEU TYR LEU VAL          
SEQRES  37 A  560  ASP ASN ARG SER TYR LEU LEU ASP PHE LYS SER ILE ASP          
SEQRES  38 A  560  ASP GLU VAL VAL GLU GLN ARG SER GLY SER SER THR PRO          
SEQRES  39 A  560  GLN ARG SER CYS SER ALA ALA GLY LEU HIS ARG PRO ARG          
SEQRES  40 A  560  SER SER PHE ASP SER THR THR ALA GLU SER HIS SER LEU          
SEQRES  41 A  560  SER GLY SER LEU THR GLY SER LEU THR GLY SER THR LEU          
SEQRES  42 A  560  SER SER VAL SER PRO ARG LEU GLY SER HIS THR MET ASP          
SEQRES  43 A  560  PHE PHE GLU MET CYS ALA SER LEU ILE THR THR LEU ALA          
SEQRES  44 A  560  ARG                                                          
SEQRES   1 B  270  MET GLY ASN THR SER SER GLU ARG ALA ALA LEU GLU ARG          
SEQRES   2 B  270  HIS GLY GLY HIS LYS THR PRO ARG ARG ASP SER SER GLY          
SEQRES   3 B  270  GLY THR LYS ASP GLY ASP ARG PRO LYS ILE LEU MET ASP          
SEQRES   4 B  270  SER PRO GLU ASP ALA ASP LEU PHE HIS SER GLU GLU ILE          
SEQRES   5 B  270  LYS ALA PRO GLU LYS GLU GLU PHE LEU ALA TRP GLN HIS          
SEQRES   6 B  270  ASP LEU GLU VAL ASN ASP LYS ALA PRO ALA GLN ALA ARG          
SEQRES   7 B  270  PRO THR VAL PHE ARG TRP THR GLY GLY GLY LYS GLU VAL          
SEQRES   8 B  270  TYR LEU SER GLY SER PHE ASN ASN TRP SER LYS LEU PRO          
SEQRES   9 B  270  LEU THR ARG SEP HIS ASN ASN PHE VAL ALA ILE LEU ASP          
SEQRES  10 B  270  LEU PRO GLU GLY GLU HIS GLN TYR LYS PHE PHE VAL ASP          
SEQRES  11 B  270  GLY GLN TRP THR HIS ASP PRO SER GLU PRO ILE VAL THR          
SEQRES  12 B  270  SER GLN LEU GLY THR VAL ASN ASN ILE ILE GLN VAL LYS          
SEQRES  13 B  270  LYS THR ASP PHE GLU VAL PHE ASP ALA LEU MET VAL ASP          
SEQRES  14 B  270  SER GLN LYS CYS SER ASP VAL SER GLU LEU SER SER SER          
SEQRES  15 B  270  PRO PRO GLY PRO TYR HIS GLN GLU PRO TYR VAL CYS LYS          
SEQRES  16 B  270  PRO GLU GLU ARG PHE ARG ALA PRO PRO ILE LEU PRO PRO          
SEQRES  17 B  270  HIS LEU LEU GLN VAL ILE LEU ASN LYS ASP THR GLY ILE          
SEQRES  18 B  270  SER CYS ASP PRO ALA LEU LEU PRO GLU PRO ASN HIS VAL          
SEQRES  19 B  270  MET LEU ASN HIS LEU TYR ALA LEU SER ILE LYS ASP GLY          
SEQRES  20 B  270  VAL MET VAL LEU SER ALA THR HIS ARG TYR LYS LYS LYS          
SEQRES  21 B  270  TYR VAL THR THR LEU LEU TYR LYS PRO ILE                      
SEQRES   1 C  560  MET GLY SER SER HIS HIS HIS HIS HIS HIS HIS SER GLN          
SEQRES   2 C  560  ASP PRO ALA GLU LYS GLN LYS HIS ASP GLY ARG VAL LYS          
SEQRES   3 C  560  ILE GLY HIS TYR VAL LEU GLY ASP THR LEU GLY VAL GLY          
SEQRES   4 C  560  THR PHE GLY LYS VAL LYS ILE GLY GLU HIS GLN LEU THR          
SEQRES   5 C  560  GLY HIS LYS VAL ALA VAL LYS ILE LEU ASN ARG GLN LYS          
SEQRES   6 C  560  ILE ARG SER LEU ASP VAL VAL GLY LYS ILE LYS ARG GLU          
SEQRES   7 C  560  ILE GLN ASN LEU LYS LEU PHE ARG HIS PRO HIS ILE ILE          
SEQRES   8 C  560  LYS LEU TYR GLN VAL ILE SER THR PRO THR ASP PHE PHE          
SEQRES   9 C  560  MET VAL MET GLU TYR VAL SER GLY GLY GLU LEU PHE ASP          
SEQRES  10 C  560  TYR ILE CYS LYS HIS GLY ARG VAL GLU GLU MET GLU ALA          
SEQRES  11 C  560  ARG ARG LEU PHE GLN GLN ILE LEU SER ALA VAL ASP TYR          
SEQRES  12 C  560  CYS HIS ARG HIS MET VAL VAL HIS ARG ASP LEU LYS PRO          
SEQRES  13 C  560  GLU ASN VAL LEU LEU ASP ALA HIS MET ASN ALA LYS ILE          
SEQRES  14 C  560  ALA ASP PHE GLY LEU SER ASN MET MET SER ASP GLY GLU          
SEQRES  15 C  560  PHE LEU ARG TPO SER CYS GLY SER PRO ASN TYR ALA ALA          
SEQRES  16 C  560  PRO GLU VAL ILE SER GLY ARG LEU TYR ALA GLY PRO GLU          
SEQRES  17 C  560  VAL ASP ILE TRP SER CYS GLY VAL ILE LEU TYR ALA LEU          
SEQRES  18 C  560  LEU CYS GLY THR LEU PRO PHE ASP ASP GLU HIS VAL PRO          
SEQRES  19 C  560  THR LEU PHE LYS LYS ILE ARG GLY GLY VAL PHE TYR ILE          
SEQRES  20 C  560  PRO GLU TYR LEU ASN ARG SER VAL ALA THR LEU LEU MET          
SEQRES  21 C  560  HIS MET LEU GLN VAL ASP PRO LEU LYS ARG ALA THR ILE          
SEQRES  22 C  560  LYS ASP ILE ARG GLU HIS GLU TRP PHE LYS GLN ASP LEU          
SEQRES  23 C  560  PRO SER TYR LEU PHE PRO GLU ASP PRO SER TYR ASP ALA          
SEQRES  24 C  560  ASN VAL ILE ASP ASP GLU ALA VAL LYS GLU VAL CYS GLU          
SEQRES  25 C  560  LYS PHE GLU CYS THR GLU SER GLU VAL MET ASN SER LEU          
SEQRES  26 C  560  TYR SER GLY ASP PRO GLN ASP GLN LEU ALA VAL ALA TYR          
SEQRES  27 C  560  HIS LEU ILE ILE ASP ASN ARG ARG ILE MET ASN GLN ALA          
SEQRES  28 C  560  SER GLU PHE TYR LEU ALA SER SER PRO PRO ASP SER PHE          
SEQRES  29 C  560  LEU ASP ASP HIS HIS LEU THR ARG PRO HIS PRO GLU ARG          
SEQRES  30 C  560  VAL PRO PHE LEU VAL ALA GLU THR PRO ARG ALA ARG HIS          
SEQRES  31 C  560  THR LEU ASP GLU LEU ASN PRO GLN LYS SER LYS HIS GLN          
SEQRES  32 C  560  GLY VAL LYS LYS ALA LYS TRP HIS LEU GLY ILE ARG SER          
SEQRES  33 C  560  GLN SER LYS PRO TYR ASP ILE MET ALA GLU VAL TYR ARG          
SEQRES  34 C  560  ALA MET LYS GLN LEU ASP PHE GLU TRP LYS VAL VAL ASN          
SEQRES  35 C  560  ALA TYR HIS LEU ARG VAL ARG ARG LYS ASN PRO VAL THR          
SEQRES  36 C  560  GLY ASN TYR VAL LYS MET SER LEU GLN LEU TYR LEU VAL          
SEQRES  37 C  560  ASP ASN ARG SER TYR LEU LEU ASP PHE LYS SER ILE ASP          
SEQRES  38 C  560  ASP GLU VAL VAL GLU GLN ARG SER GLY SER SER THR PRO          
SEQRES  39 C  560  GLN ARG SER CYS SER ALA ALA GLY LEU HIS ARG PRO ARG          
SEQRES  40 C  560  SER SER PHE ASP SER THR THR ALA GLU SER HIS SER LEU          
SEQRES  41 C  560  SER GLY SER LEU THR GLY SER LEU THR GLY SER THR LEU          
SEQRES  42 C  560  SER SER VAL SER PRO ARG LEU GLY SER HIS THR MET ASP          
SEQRES  43 C  560  PHE PHE GLU MET CYS ALA SER LEU ILE THR THR LEU ALA          
SEQRES  44 C  560  ARG                                                          
SEQRES   1 D  270  MET GLY ASN THR SER SER GLU ARG ALA ALA LEU GLU ARG          
SEQRES   2 D  270  HIS GLY GLY HIS LYS THR PRO ARG ARG ASP SER SER GLY          
SEQRES   3 D  270  GLY THR LYS ASP GLY ASP ARG PRO LYS ILE LEU MET ASP          
SEQRES   4 D  270  SER PRO GLU ASP ALA ASP LEU PHE HIS SER GLU GLU ILE          
SEQRES   5 D  270  LYS ALA PRO GLU LYS GLU GLU PHE LEU ALA TRP GLN HIS          
SEQRES   6 D  270  ASP LEU GLU VAL ASN ASP LYS ALA PRO ALA GLN ALA ARG          
SEQRES   7 D  270  PRO THR VAL PHE ARG TRP THR GLY GLY GLY LYS GLU VAL          
SEQRES   8 D  270  TYR LEU SER GLY SER PHE ASN ASN TRP SER LYS LEU PRO          
SEQRES   9 D  270  LEU THR ARG SEP HIS ASN ASN PHE VAL ALA ILE LEU ASP          
SEQRES  10 D  270  LEU PRO GLU GLY GLU HIS GLN TYR LYS PHE PHE VAL ASP          
SEQRES  11 D  270  GLY GLN TRP THR HIS ASP PRO SER GLU PRO ILE VAL THR          
SEQRES  12 D  270  SER GLN LEU GLY THR VAL ASN ASN ILE ILE GLN VAL LYS          
SEQRES  13 D  270  LYS THR ASP PHE GLU VAL PHE ASP ALA LEU MET VAL ASP          
SEQRES  14 D  270  SER GLN LYS CYS SER ASP VAL SER GLU LEU SER SER SER          
SEQRES  15 D  270  PRO PRO GLY PRO TYR HIS GLN GLU PRO TYR VAL CYS LYS          
SEQRES  16 D  270  PRO GLU GLU ARG PHE ARG ALA PRO PRO ILE LEU PRO PRO          
SEQRES  17 D  270  HIS LEU LEU GLN VAL ILE LEU ASN LYS ASP THR GLY ILE          
SEQRES  18 D  270  SER CYS ASP PRO ALA LEU LEU PRO GLU PRO ASN HIS VAL          
SEQRES  19 D  270  MET LEU ASN HIS LEU TYR ALA LEU SER ILE LYS ASP GLY          
SEQRES  20 D  270  VAL MET VAL LEU SER ALA THR HIS ARG TYR LYS LYS LYS          
SEQRES  21 D  270  TYR VAL THR THR LEU LEU TYR LYS PRO ILE                      
SEQRES   1 E  336  MET ALA ASP LEU ASN TRP GLU THR VAL ILE SER SER ASP          
SEQRES   2 E  336  SER SER PRO ALA VAL GLU ASN GLU HIS PRO GLN GLU THR          
SEQRES   3 E  336  PRO GLU SER ASN ASN SER VAL TYR THR SER PHE MET LYS          
SEQRES   4 E  336  SER HIS ARG CYS TYR ASP LEU ILE PRO THR SER SER LYS          
SEQRES   5 E  336  LEU VAL VAL PHE ASP THR SER LEU GLN VAL LYS LYS ALA          
SEQRES   6 E  336  PHE PHE ALA LEU VAL THR ASN GLY VAL ARG ALA ALA PRO          
SEQRES   7 E  336  LEU TRP ASP SER LYS LYS GLN SER PHE VAL GLY MET LEU          
SEQRES   8 E  336  THR ILE THR ASP PHE ILE ASN ILE LEU HIS ARG TYR TYR          
SEQRES   9 E  336  LYS SER ALA LEU VAL GLN ILE TYR GLU LEU GLU GLU HIS          
SEQRES  10 E  336  LYS ILE GLU THR TRP ARG GLU VAL TYR LEU GLN ASP SER          
SEQRES  11 E  336  PHE LYS PRO LEU VAL CYS ILE SER PRO ASN ALA SER LEU          
SEQRES  12 E  336  PHE ASP ALA VAL SER SER LEU ILE ARG ASN LYS ILE HIS          
SEQRES  13 E  336  ARG LEU PRO VAL ILE ASP PRO GLU SER GLY ASN THR LEU          
SEQRES  14 E  336  TYR ILE LEU THR HIS LYS ARG ILE LEU LYS PHE LEU LYS          
SEQRES  15 E  336  LEU PHE ILE THR GLU PHE PRO LYS PRO GLU PHE MET SER          
SEQRES  16 E  336  LYS SER LEU GLU GLU LEU GLN ILE GLY THR TYR ALA ASN          
SEQRES  17 E  336  ILE ALA MET VAL ARG THR THR THR PRO VAL TYR VAL ALA          
SEQRES  18 E  336  LEU GLY ILE PHE VAL GLN HIS ARG VAL SER ALA LEU PRO          
SEQRES  19 E  336  VAL VAL ASP GLU LYS GLY ARG VAL VAL ASP ILE TYR SER          
SEQRES  20 E  336  LYS PHE ASP VAL ILE ASN LEU ALA ALA GLU LYS THR TYR          
SEQRES  21 E  336  ASN ASN LEU ASP VAL SER VAL THR LYS ALA LEU GLN HIS          
SEQRES  22 E  336  ARG SER HIS TYR PHE GLU GLY VAL LEU LYS CYS TYR LEU          
SEQRES  23 E  336  HIS GLU THR LEU GLU THR ILE ILE ASN ARG LEU VAL GLU          
SEQRES  24 E  336  ALA GLU VAL HIS ARG LEU VAL VAL VAL ASP GLU ASN ASP          
SEQRES  25 E  336  VAL VAL LYS GLY ILE VAL SER LEU SER ASP ILE LEU GLN          
SEQRES  26 E  336  ALA LEU VAL LEU THR GLY GLY GLU LYS LYS PRO                  
SEQRES   1 F  336  MET ALA ASP LEU ASN TRP GLU THR VAL ILE SER SER ASP          
SEQRES   2 F  336  SER SER PRO ALA VAL GLU ASN GLU HIS PRO GLN GLU THR          
SEQRES   3 F  336  PRO GLU SER ASN ASN SER VAL TYR THR SER PHE MET LYS          
SEQRES   4 F  336  SER HIS ARG CYS TYR ASP LEU ILE PRO THR SER SER LYS          
SEQRES   5 F  336  LEU VAL VAL PHE ASP THR SER LEU GLN VAL LYS LYS ALA          
SEQRES   6 F  336  PHE PHE ALA LEU VAL THR ASN GLY VAL ARG ALA ALA PRO          
SEQRES   7 F  336  LEU TRP ASP SER LYS LYS GLN SER PHE VAL GLY MET LEU          
SEQRES   8 F  336  THR ILE THR ASP PHE ILE ASN ILE LEU HIS ARG TYR TYR          
SEQRES   9 F  336  LYS SER ALA LEU VAL GLN ILE TYR GLU LEU GLU GLU HIS          
SEQRES  10 F  336  LYS ILE GLU THR TRP ARG GLU VAL TYR LEU GLN ASP SER          
SEQRES  11 F  336  PHE LYS PRO LEU VAL CYS ILE SER PRO ASN ALA SER LEU          
SEQRES  12 F  336  PHE ASP ALA VAL SER SER LEU ILE ARG ASN LYS ILE HIS          
SEQRES  13 F  336  ARG LEU PRO VAL ILE ASP PRO GLU SER GLY ASN THR LEU          
SEQRES  14 F  336  TYR ILE LEU THR HIS LYS ARG ILE LEU LYS PHE LEU LYS          
SEQRES  15 F  336  LEU PHE ILE THR GLU PHE PRO LYS PRO GLU PHE MET SER          
SEQRES  16 F  336  LYS SER LEU GLU GLU LEU GLN ILE GLY THR TYR ALA ASN          
SEQRES  17 F  336  ILE ALA MET VAL ARG THR THR THR PRO VAL TYR VAL ALA          
SEQRES  18 F  336  LEU GLY ILE PHE VAL GLN HIS ARG VAL SER ALA LEU PRO          
SEQRES  19 F  336  VAL VAL ASP GLU LYS GLY ARG VAL VAL ASP ILE TYR SER          
SEQRES  20 F  336  LYS PHE ASP VAL ILE ASN LEU ALA ALA GLU LYS THR TYR          
SEQRES  21 F  336  ASN ASN LEU ASP VAL SER VAL THR LYS ALA LEU GLN HIS          
SEQRES  22 F  336  ARG SER HIS TYR PHE GLU GLY VAL LEU LYS CYS TYR LEU          
SEQRES  23 F  336  HIS GLU THR LEU GLU THR ILE ILE ASN ARG LEU VAL GLU          
SEQRES  24 F  336  ALA GLU VAL HIS ARG LEU VAL VAL VAL ASP GLU ASN ASP          
SEQRES  25 F  336  VAL VAL LYS GLY ILE VAL SER LEU SER ASP ILE LEU GLN          
SEQRES  26 F  336  ALA LEU VAL LEU THR GLY GLY GLU LYS LYS PRO                  
MODRES 5EZV TPO A  172  THR  MODIFIED RESIDUE                                   
MODRES 5EZV SEP B  108  SER  MODIFIED RESIDUE                                   
MODRES 5EZV TPO C  172  THR  MODIFIED RESIDUE                                   
MODRES 5EZV SEP D  108  SER  MODIFIED RESIDUE                                   
HET    TPO  A 172      11                                                       
HET    SEP  B 108      10                                                       
HET    TPO  C 172      11                                                       
HET    SEP  D 108      10                                                       
HET    STU  A 601      35                                                       
HET    C1V  A 602      26                                                       
HET    STU  C 601      35                                                       
HET    C1V  C 602      26                                                       
HET    C2Z  E 401      15                                                       
HET    C2Z  E 402      15                                                       
HET    C2Z  F 401      15                                                       
HET    C2Z  F 402      15                                                       
HETNAM     TPO PHOSPHOTHREONINE                                                 
HETNAM     SEP PHOSPHOSERINE                                                    
HETNAM     STU STAUROSPORINE                                                    
HETNAM     C1V 3-[4-(2-HYDROXYPHENYL)PHENYL]-4-OXIDANYL-6-                      
HETNAM   2 C1V  OXIDANYLIDENE-7H-THIENO[2,3-B]PYRIDINE-5-CARBONITRILE           
HETNAM     C2Z 5-(5-HYDROXYL-ISOXAZOL-3-YL)-FURAN-2-PHOSPHONIC ACID             
HETSYN     TPO PHOSPHONOTHREONINE                                               
HETSYN     SEP PHOSPHONOSERINE                                                  
HETSYN     C2Z [5-(5-HYDROXY-1,2-OXAZOL-3-YL)FURAN-2-YL]PHOSPHONIC              
HETSYN   2 C2Z  ACID                                                            
FORMUL   1  TPO    2(C4 H10 N O6 P)                                             
FORMUL   2  SEP    2(C3 H8 N O6 P)                                              
FORMUL   7  STU    2(C28 H26 N4 O3)                                             
FORMUL   8  C1V    2(C20 H12 N2 O3 S)                                           
FORMUL  11  C2Z    4(C7 H6 N O6 P)                                              
FORMUL  15  HOH   *84(H2 O)                                                     
HELIX    1 AA1 ARG A   49  ASP A   56  1                                   8    
HELIX    2 AA2 VAL A   57  PHE A   71  1                                  15    
HELIX    3 AA3 LEU A  101  GLY A  109  1                                   9    
HELIX    4 AA4 GLU A  112  HIS A  133  1                                  22    
HELIX    5 AA5 ALA A  181  SER A  186  1                                   6    
HELIX    6 AA6 GLY A  192  GLY A  210  1                                  19    
HELIX    7 AA7 HIS A  218  GLY A  229  1                                  12    
HELIX    8 AA8 ASN A  238  LEU A  249  1                                  12    
HELIX    9 AA9 THR A  258  HIS A  265  1                                   8    
HELIX   10 AB1 HIS A  265  GLN A  270  1                                   6    
HELIX   11 AB2 SER A  282  VAL A  287  1                                   6    
HELIX   12 AB3 ASP A  289  GLU A  301  1                                  13    
HELIX   13 AB4 THR A  303  SER A  313  1                                  11    
HELIX   14 AB5 ASP A  318  ALA A  337  1                                  20    
HELIX   15 AB6 ALA A  337  LEU A  342  1                                   6    
HELIX   16 AB7 HIS A  360  VAL A  364  5                                   5    
HELIX   17 AB8 LYS A  405  ASP A  421  1                                  17    
HELIX   18 AB9 SER A  528  ALA A  545  1                                  18    
HELIX   19 AC1 PHE B   97  ASN B   99  5                                   3    
HELIX   20 AC2 LYS B  156  PHE B  160  5                                   5    
HELIX   21 AC3 GLU B  161  SER B  174  1                                  14    
HELIX   22 AC4 ASN B  232  LEU B  236  5                                   5    
HELIX   23 AC5 ARG C   49  LEU C   55  1                                   7    
HELIX   24 AC6 VAL C   57  PHE C   71  1                                  15    
HELIX   25 AC7 LEU C  101  HIS C  108  1                                   8    
HELIX   26 AC8 GLU C  112  HIS C  133  1                                  22    
HELIX   27 AC9 ALA C  181  SER C  186  1                                   6    
HELIX   28 AD1 GLY C  192  GLY C  210  1                                  19    
HELIX   29 AD2 HIS C  218  GLY C  229  1                                  12    
HELIX   30 AD3 ASN C  238  LEU C  249  1                                  12    
HELIX   31 AD4 THR C  258  HIS C  265  1                                   8    
HELIX   32 AD5 GLU C  291  PHE C  300  1                                  10    
HELIX   33 AD6 THR C  303  SER C  313  1                                  11    
HELIX   34 AD7 LEU C  320  ALA C  337  1                                  18    
HELIX   35 AD8 ALA C  337  LEU C  342  1                                   6    
HELIX   36 AD9 LYS C  405  LEU C  420  1                                  16    
HELIX   37 AE1 SER C  528  ALA C  545  1                                  18    
HELIX   38 AE2 PHE D   97  ASN D   99  5                                   3    
HELIX   39 AE3 LYS D  157  PHE D  160  5                                   4    
HELIX   40 AE4 GLU D  161  LEU D  179  1                                  19    
HELIX   41 AE5 PRO D  207  GLN D  212  5                                   6    
HELIX   42 AE6 ASN D  232  LEU D  236  5                                   5    
HELIX   43 AE7 SER E   27  HIS E   36  1                                  10    
HELIX   44 AE8 ARG E   37  ILE E   42  5                                   6    
HELIX   45 AE9 GLN E   56  GLY E   68  1                                  13    
HELIX   46 AF1 ILE E   88  TYR E   99  1                                  12    
HELIX   47 AF2 ILE E  106  HIS E  112  1                                   7    
HELIX   48 AF3 LYS E  113  LEU E  122  1                                  10    
HELIX   49 AF4 SER E  137  ASN E  148  1                                  12    
HELIX   50 AF5 THR E  168  LYS E  177  1                                  10    
HELIX   51 AF6 PRO E  186  LYS E  191  1                                   6    
HELIX   52 AF7 SER E  192  GLN E  197  1                                   6    
HELIX   53 AF8 PRO E  212  HIS E  223  1                                  12    
HELIX   54 AF9 PHE E  244  VAL E  246  5                                   3    
HELIX   55 AG1 ILE E  247  GLU E  252  1                                   6    
HELIX   56 AG2 SER E  261  GLN E  267  1                                   7    
HELIX   57 AG3 THR E  284  GLU E  296  1                                  13    
HELIX   58 AG4 LEU E  315  VAL E  323  1                                   9    
HELIX   59 AG5 SER F   27  HIS F   36  1                                  10    
HELIX   60 AG6 GLN F   56  GLY F   68  1                                  13    
HELIX   61 AG7 THR F   87  TYR F   99  1                                  13    
HELIX   62 AG8 ILE F  106  HIS F  112  1                                   7    
HELIX   63 AG9 LYS F  113  LEU F  122  1                                  10    
HELIX   64 AH1 SER F  137  ASN F  148  1                                  12    
HELIX   65 AH2 THR F  168  PHE F  179  1                                  12    
HELIX   66 AH3 PRO F  186  LYS F  191  5                                   6    
HELIX   67 AH4 SER F  192  GLN F  197  1                                   6    
HELIX   68 AH5 PRO F  212  HIS F  223  1                                  12    
HELIX   69 AH6 PHE F  244  VAL F  246  5                                   3    
HELIX   70 AH7 ILE F  247  GLU F  252  1                                   6    
HELIX   71 AH8 SER F  261  HIS F  271  1                                  11    
HELIX   72 AH9 THR F  284  GLU F  296  1                                  13    
HELIX   73 AI1 LEU F  315  LEU F  324  1                                  10    
SHEET    1 AA1 6 LYS A  12  ILE A  13  0                                        
SHEET    2 AA1 6 TYR A  16  VAL A  24 -1  O  TYR A  16   N  ILE A  13           
SHEET    3 AA1 6 LYS A  29  HIS A  35 -1  O  GLU A  34   N  VAL A  17           
SHEET    4 AA1 6 LYS A  41  ASN A  48 -1  O  VAL A  42   N  GLY A  33           
SHEET    5 AA1 6 ASP A  88  GLU A  94 -1  O  MET A  93   N  ALA A  43           
SHEET    6 AA1 6 LEU A  79  SER A  84 -1  N  ILE A  83   O  PHE A  90           
SHEET    1 AA2 3 GLY A  99  GLU A 100  0                                        
SHEET    2 AA2 3 VAL A 145  LEU A 147 -1  O  LEU A 147   N  GLY A  99           
SHEET    3 AA2 3 ALA A 153  ILE A 155 -1  O  LYS A 154   N  LEU A 146           
SHEET    1 AA3 2 VAL A 135  VAL A 136  0                                        
SHEET    2 AA3 2 ASN A 162  MET A 163 -1  O  ASN A 162   N  VAL A 136           
SHEET    1 AA4 7 HIS A 397  LEU A 398  0                                        
SHEET    2 AA4 7 LEU B 239  ALA B 241 -1  O  ALA B 241   N  HIS A 397           
SHEET    3 AA4 7 VAL B 248  ARG B 256 -1  O  SER B 252   N  TYR B 240           
SHEET    4 AA4 7 TYR B 261  PRO B 269 -1  O  VAL B 262   N  HIS B 255           
SHEET    5 AA4 7 SER E  45  ASP E  52  1  O  VAL E  50   N  LEU B 265           
SHEET    6 AA4 7 ALA E  71  TRP E  75  1  O  TRP E  75   N  PHE E  51           
SHEET    7 AA4 7 PHE E  82  THR E  87 -1  O  GLY E  84   N  LEU E  74           
SHEET    1 AA5 5 ILE A 400  SER A 402  0                                        
SHEET    2 AA5 5 TYR A 459  SER A 465 -1  O  TYR A 459   N  SER A 402           
SHEET    3 AA5 5 TYR A 444  LEU A 453 -1  N  GLN A 450   O  ASP A 462           
SHEET    4 AA5 5 HIS A 431  LYS A 437 -1  N  ARG A 436   O  VAL A 445           
SHEET    5 AA5 5 GLU A 423  LYS A 425 -1  N  GLU A 423   O  ARG A 435           
SHEET    1 AA6 3 PRO B  79  TRP B  84  0                                        
SHEET    2 AA6 3 ASN B 111  ASP B 117 -1  O  PHE B 112   N  TRP B  84           
SHEET    3 AA6 3 THR B 106  SEP B 108 -1  N  SEP B 108   O  ASN B 111           
SHEET    1 AA7 4 LEU B 103  PRO B 104  0                                        
SHEET    2 AA7 4 VAL B  91  GLY B  95 -1  N  LEU B  93   O  LEU B 103           
SHEET    3 AA7 4 GLY B 121  VAL B 129 -1  O  LYS B 126   N  SER B  94           
SHEET    4 AA7 4 GLN B 132  THR B 134 -1  O  THR B 134   N  PHE B 127           
SHEET    1 AA8 5 LEU B 103  PRO B 104  0                                        
SHEET    2 AA8 5 VAL B  91  GLY B  95 -1  N  LEU B  93   O  LEU B 103           
SHEET    3 AA8 5 GLY B 121  VAL B 129 -1  O  LYS B 126   N  SER B  94           
SHEET    4 AA8 5 VAL B 149  VAL B 155 -1  O  ILE B 153   N  HIS B 123           
SHEET    5 AA8 5 ILE B 141  THR B 143 -1  N  VAL B 142   O  ASN B 150           
SHEET    1 AA9 6 LYS C  12  ILE C  13  0                                        
SHEET    2 AA9 6 TYR C  16  VAL C  24 -1  O  TYR C  16   N  ILE C  13           
SHEET    3 AA9 6 LYS C  29  HIS C  35 -1  O  GLU C  34   N  VAL C  17           
SHEET    4 AA9 6 LYS C  41  ASN C  48 -1  O  VAL C  44   N  LYS C  31           
SHEET    5 AA9 6 ASP C  88  GLU C  94 -1  O  MET C  93   N  ALA C  43           
SHEET    6 AA9 6 LEU C  79  SER C  84 -1  N  ILE C  83   O  PHE C  90           
SHEET    1 AB1 3 GLY C  99  GLU C 100  0                                        
SHEET    2 AB1 3 VAL C 145  LEU C 147 -1  O  LEU C 147   N  GLY C  99           
SHEET    3 AB1 3 ALA C 153  ILE C 155 -1  O  LYS C 154   N  LEU C 146           
SHEET    1 AB2 2 VAL C 135  VAL C 136  0                                        
SHEET    2 AB2 2 ASN C 162  MET C 163 -1  O  ASN C 162   N  VAL C 136           
SHEET    1 AB3 7 HIS C 397  LEU C 398  0                                        
SHEET    2 AB3 7 LEU D 239  LYS D 245 -1  O  ALA D 241   N  HIS C 397           
SHEET    3 AB3 7 VAL D 248  TYR D 257 -1  O  SER D 252   N  TYR D 240           
SHEET    4 AB3 7 LYS D 260  LYS D 268 -1  O  LYS D 268   N  MET D 249           
SHEET    5 AB3 7 SER F  45  ASP F  52  1  O  LEU F  48   N  LEU D 265           
SHEET    6 AB3 7 ALA F  72  ASP F  76  1  O  TRP F  75   N  PHE F  51           
SHEET    7 AB3 7 SER F  81  LEU F  86 -1  O  GLY F  84   N  LEU F  74           
SHEET    1 AB4 5 ILE C 400  SER C 402  0                                        
SHEET    2 AB4 5 SER C 458  SER C 465 -1  O  TYR C 459   N  SER C 402           
SHEET    3 AB4 5 TYR C 444  VAL C 454 -1  N  SER C 448   O  LYS C 464           
SHEET    4 AB4 5 HIS C 431  LYS C 437 -1  N  ARG C 436   O  VAL C 445           
SHEET    5 AB4 5 GLU C 423  VAL C 426 -1  N  GLU C 423   O  ARG C 435           
SHEET    1 AB5 3 PRO D  79  TRP D  84  0                                        
SHEET    2 AB5 3 PHE D 112  ASP D 117 -1  O  PHE D 112   N  TRP D  84           
SHEET    3 AB5 3 THR D 106  ARG D 107 -1  N  THR D 106   O  VAL D 113           
SHEET    1 AB6 4 LEU D 103  PRO D 104  0                                        
SHEET    2 AB6 4 VAL D  91  GLY D  95 -1  N  LEU D  93   O  LEU D 103           
SHEET    3 AB6 4 GLY D 121  VAL D 129 -1  O  LYS D 126   N  SER D  94           
SHEET    4 AB6 4 TRP D 133  THR D 134 -1  O  THR D 134   N  PHE D 127           
SHEET    1 AB7 5 LEU D 103  PRO D 104  0                                        
SHEET    2 AB7 5 VAL D  91  GLY D  95 -1  N  LEU D  93   O  LEU D 103           
SHEET    3 AB7 5 GLY D 121  VAL D 129 -1  O  LYS D 126   N  SER D  94           
SHEET    4 AB7 5 VAL D 149  VAL D 155 -1  O  VAL D 155   N  GLY D 121           
SHEET    5 AB7 5 ILE D 141  THR D 143 -1  N  VAL D 142   O  ASN D 150           
SHEET    1 AB8 2 LEU E 153  ILE E 156  0                                        
SHEET    2 AB8 2 THR E 163  LEU E 167 -1  O  LEU E 164   N  VAL E 155           
SHEET    1 AB9 3 VAL E 207  ARG E 208  0                                        
SHEET    2 AB9 3 ALA E 227  VAL E 231  1  O  VAL E 231   N  VAL E 207           
SHEET    3 AB9 3 VAL E 237  SER E 242 -1  O  TYR E 241   N  LEU E 228           
SHEET    1 AC1 3 LYS E 278  TYR E 280  0                                        
SHEET    2 AC1 3 ARG E 299  VAL E 303  1  O  VAL E 303   N  CYS E 279           
SHEET    3 AC1 3 VAL E 309  SER E 314 -1  O  LYS E 310   N  VAL E 302           
SHEET    1 AC2 2 LEU F 153  ILE F 156  0                                        
SHEET    2 AC2 2 THR F 163  LEU F 167 -1  O  TYR F 165   N  VAL F 155           
SHEET    1 AC3 3 VAL F 207  ARG F 208  0                                        
SHEET    2 AC3 3 ALA F 227  VAL F 231  1  O  VAL F 231   N  VAL F 207           
SHEET    3 AC3 3 VAL F 237  SER F 242 -1  O  TYR F 241   N  LEU F 228           
SHEET    1 AC4 3 LYS F 278  TYR F 280  0                                        
SHEET    2 AC4 3 ARG F 299  VAL F 303  1  O  VAL F 303   N  CYS F 279           
SHEET    3 AC4 3 VAL F 309  SER F 314 -1  O  LYS F 310   N  VAL F 302           
LINK         OD2 ASP A 166                 NH2 ARG B 256     1555   1555  1.36  
LINK         C   ARG A 171                 N   TPO A 172     1555   1555  1.33  
LINK         C   TPO A 172                 N   SER A 173     1555   1555  1.33  
LINK         C   ARG B 107                 N   SEP B 108     1555   1555  1.33  
LINK         C   SEP B 108                 N   HIS B 109     1555   1555  1.32  
LINK         C   ARG C 171                 N   TPO C 172     1555   1555  1.33  
LINK         C   TPO C 172                 N   SER C 173     1555   1555  1.33  
LINK         C   ARG D 107                 N   SEP D 108     1555   1555  1.32  
LINK         C   SEP D 108                 N   HIS D 109     1555   1555  1.32  
SITE     1 AC1 14 LEU A  22  GLY A  23  VAL A  24  GLY A  25                    
SITE     2 AC1 14 VAL A  30  ALA A  43  MET A  93  GLU A  94                    
SITE     3 AC1 14 TYR A  95  VAL A  96  GLU A 100  GLU A 143                    
SITE     4 AC1 14 ASN A 144  LEU A 146                                          
SITE     1 AC2 10 LEU A  18  GLY A  19  LYS A  29  LYS A  31                    
SITE     2 AC2 10 ILE A  46  ASP A  88  ARG B  83  THR B 106                    
SITE     3 AC2 10 SEP B 108  VAL B 113                                          
SITE     1 AC3 14 LEU C  22  GLY C  23  VAL C  24  GLY C  25                    
SITE     2 AC3 14 VAL C  30  ALA C  43  GLU C  94  TYR C  95                    
SITE     3 AC3 14 VAL C  96  GLU C 100  GLU C 143  ASN C 144                    
SITE     4 AC3 14 LEU C 146  ASP C 157                                          
SITE     1 AC4 12 VAL C  11  LEU C  18  GLY C  19  LYS C  29                    
SITE     2 AC4 12 LYS C  31  ILE C  46  ASN C  48  ASP C  88                    
SITE     3 AC4 12 ARG D  83  ARG D 107  SEP D 108  VAL D 113                    
SITE     1 AC5  8 HIS E 151  ARG E 152  SER E 226  HIS E 298                    
SITE     2 AC5  8 ARG E 299  SER E 314  SER E 316  C2Z E 402                    
SITE     1 AC6 10 ARG E  70  THR E  87  THR E  89  HIS E 151                    
SITE     2 AC6 10 SER E 226  SER E 242  LYS E 243  PHE E 244                    
SITE     3 AC6 10 ARG E 299  C2Z E 401                                          
SITE     1 AC7  8 HIS F 151  ARG F 152  SER F 226  HIS F 298                    
SITE     2 AC7  8 ARG F 299  SER F 314  SER F 316  C2Z F 402                    
SITE     1 AC8 11 ARG F  70  THR F  87  THR F  89  HIS F 151                    
SITE     2 AC8 11 SER F 226  SER F 242  LYS F 243  PHE F 244                    
SITE     3 AC8 11 HIS F 298  ARG F 299  C2Z F 401                               
CRYST1   75.608  134.112  141.287  90.00  93.16  90.00 P 1 21 1      4          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.013226  0.000000  0.000730        0.00000                         
SCALE2      0.000000  0.007456  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.007089        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system