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Database: PDB
Entry: 5FGC
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HEADER    VIRAL PROTEIN                           20-DEC-15   5FGC              
TITLE     THREE DIMENSIONAL STRUCTURE OF BROADLY NEUTRALIZING HUMAN ANTI -      
TITLE    2 HEPATITIS C VIRUS (HCV) GLYCOPROTEIN E2 FAB FRAGMENT HC33.8          
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: GENOME POLYPROTEIN;                                        
COMPND   3 CHAIN: A;                                                            
COMPND   4 EC: 3.4.22.-,3.4.21.98,3.6.1.15,3.6.4.13,2.7.7.48;                   
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: ANTI-HCV E2 FAB HC33.8 LIGHT CHAIN;                        
COMPND   8 CHAIN: B;                                                            
COMPND   9 ENGINEERED: YES;                                                     
COMPND  10 MOL_ID: 3;                                                           
COMPND  11 MOLECULE: ANTI-HCV E2 FAB HC33.8 HEAVY CHAIN;                        
COMPND  12 CHAIN: E;                                                            
COMPND  13 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 SYNTHETIC: YES;                                                      
SOURCE   3 ORGANISM_SCIENTIFIC: HEPATITIS C VIRUS GENOTYPE 1A (ISOLATE H);      
SOURCE   4 ORGANISM_COMMON: HCV;                                                
SOURCE   5 ORGANISM_TAXID: 11108;                                               
SOURCE   6 MOL_ID: 2;                                                           
SOURCE   7 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   8 ORGANISM_TAXID: 9606;                                                
SOURCE   9 EXPRESSION_SYSTEM: DROSOPHILA;                                       
SOURCE  10 EXPRESSION_SYSTEM_TAXID: 7215;                                       
SOURCE  11 EXPRESSION_SYSTEM_CELL_LINE: SCHNEIDER 2;                            
SOURCE  12 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  13 EXPRESSION_SYSTEM_PLASMID: PMT/BIP MODIFIED;                         
SOURCE  14 MOL_ID: 3;                                                           
SOURCE  15 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  16 ORGANISM_TAXID: 9606;                                                
SOURCE  17 EXPRESSION_SYSTEM: DROSOPHILA;                                       
SOURCE  18 EXPRESSION_SYSTEM_TAXID: 7215;                                       
SOURCE  19 EXPRESSION_SYSTEM_CELL_LINE: SCHNEIDER 2;                            
SOURCE  20 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  21 EXPRESSION_SYSTEM_PLASMID: PMT/BIP MODIFIED                          
KEYWDS    FAB FRAGMENT, NEUTRALIZING ANTIBODY, HEPATITIS C VIRUS E2, VIRAL      
KEYWDS   2 PROTEIN                                                              
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    C.GIRARD-BLANC,F.A.REY,T.KREY                                         
REVDAT   2   09-MAR-16 5FGC    1       JRNL                                     
REVDAT   1   20-JAN-16 5FGC    0                                                
JRNL        AUTH   Z.Y.KECK,C.GIRARD-BLANC,W.WANG,P.LAU,A.ZUIANI,F.A.REY,       
JRNL        AUTH 2 T.KREY,M.S.DIAMOND,S.K.FOUNG                                 
JRNL        TITL   ANTIBODY RESPONSE TO HYPERVARIABLE REGION 1 INTERFERES WITH  
JRNL        TITL 2 BROADLY NEUTRALIZING ANTIBODIES TO HEPATITIS C VIRUS.        
JRNL        REF    J.VIROL.                      V.  90  3112 2016              
JRNL        REFN                   ESSN 1098-5514                               
JRNL        PMID   26739044                                                     
JRNL        DOI    10.1128/JVI.02458-15                                         
REMARK   2                                                                      
REMARK   2 RESOLUTION.    1.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : BUSTER 2.11.2                                        
REMARK   3   AUTHORS     : BRICOGNE,BLANC,BRANDL,FLENSBURG,KELLER,              
REMARK   3               : PACIOREK,ROVERSI,SHARFF,SMART,VONRHEIN,              
REMARK   3               : WOMACK,MATTHEWS,TEN EYCK,TRONRUD                     
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.90                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 49.57                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.9                           
REMARK   3   NUMBER OF REFLECTIONS             : 33727                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD           : THROUGHOUT                     
REMARK   3   FREE R VALUE TEST SET SELECTION   : RANDOM                         
REMARK   3   R VALUE     (WORKING + TEST SET)  : 0.196                          
REMARK   3   R VALUE            (WORKING SET)  : 0.194                          
REMARK   3   FREE R VALUE                      : 0.236                          
REMARK   3   FREE R VALUE TEST SET SIZE   (%)  : 5.000                          
REMARK   3   FREE R VALUE TEST SET COUNT       : 1687                           
REMARK   3   ESTIMATED ERROR OF FREE R VALUE   : NULL                           
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED               : 17                       
REMARK   3   BIN RESOLUTION RANGE HIGH   (ANGSTROMS) : 1.90                     
REMARK   3   BIN RESOLUTION RANGE LOW    (ANGSTROMS) : 2.01                     
REMARK   3   BIN COMPLETENESS (WORKING+TEST)     (%) : 98.20                    
REMARK   3   REFLECTIONS IN BIN (WORKING + TEST SET) : 5345                     
REMARK   3   BIN R VALUE        (WORKING + TEST SET) : 0.2429                   
REMARK   3   REFLECTIONS IN BIN        (WORKING SET) : 2741                     
REMARK   3   BIN R VALUE               (WORKING SET) : 0.2417                   
REMARK   3   BIN FREE R VALUE                        : 0.2652                   
REMARK   3   BIN FREE R VALUE TEST SET SIZE      (%) : 4.99                     
REMARK   3   BIN FREE R VALUE TEST SET COUNT         : 144                      
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE     : NULL                     
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 3401                                    
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 116                                     
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 39.81                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 61.65                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -10.10550                                            
REMARK   3    B22 (A**2) : -5.28920                                             
REMARK   3    B33 (A**2) : 15.39460                                             
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : -2.64280                                             
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT                    (A) : 0.407               
REMARK   3   DPI (BLOW EQ-10) BASED ON R VALUE        (A) : 0.153               
REMARK   3   DPI (BLOW EQ-9) BASED ON FREE R VALUE    (A) : 0.142               
REMARK   3   DPI (CRUICKSHANK) BASED ON R VALUE       (A) : 0.156               
REMARK   3   DPI (CRUICKSHANK) BASED ON FREE R VALUE  (A) : 0.145               
REMARK   3                                                                      
REMARK   3   REFERENCES: BLOW, D. (2002) ACTA CRYST D58, 792-797                
REMARK   3               CRUICKSHANK, D.W.J. (1999) ACTA CRYST D55, 583-601     
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.944                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.928                         
REMARK   3                                                                      
REMARK   3   NUMBER OF GEOMETRIC FUNCTION TERMS DEFINED : 15                    
REMARK   3   TERM                          COUNT    WEIGHT   FUNCTION.          
REMARK   3    BOND LENGTHS              : 3500   ; 2.000  ; HARMONIC            
REMARK   3    BOND ANGLES               : 4773   ; 2.000  ; HARMONIC            
REMARK   3    TORSION ANGLES            : 1145   ; 2.000  ; SINUSOIDAL          
REMARK   3    TRIGONAL CARBON PLANES    : 76     ; 2.000  ; HARMONIC            
REMARK   3    GENERAL PLANES            : 513    ; 5.000  ; HARMONIC            
REMARK   3    ISOTROPIC THERMAL FACTORS : 3500   ; 20.000 ; HARMONIC            
REMARK   3    BAD NON-BONDED CONTACTS   : NULL   ; NULL   ; NULL                
REMARK   3    IMPROPER TORSIONS         : NULL   ; NULL   ; NULL                
REMARK   3    PSEUDOROTATION ANGLES     : NULL   ; NULL   ; NULL                
REMARK   3    CHIRAL IMPROPER TORSION   : 464    ; 5.000  ; SEMIHARMONIC        
REMARK   3    SUM OF OCCUPANCIES        : NULL   ; NULL   ; NULL                
REMARK   3    UTILITY DISTANCES         : NULL   ; NULL   ; NULL                
REMARK   3    UTILITY ANGLES            : NULL   ; NULL   ; NULL                
REMARK   3    UTILITY TORSION           : NULL   ; NULL   ; NULL                
REMARK   3    IDEAL-DIST CONTACT TERM   : 3876   ; 4.000  ; SEMIHARMONIC        
REMARK   3                                                                      
REMARK   3   RMS DEVIATIONS FROM IDEAL VALUES.                                  
REMARK   3    BOND LENGTHS                       (A) : 0.010                    
REMARK   3    BOND ANGLES                  (DEGREES) : 1.16                     
REMARK   3    PEPTIDE OMEGA TORSION ANGLES (DEGREES) : 3.72                     
REMARK   3    OTHER TORSION ANGLES         (DEGREES) : 16.24                    
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 41                                         
REMARK   3                                                                      
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: {B|1 - 5}                                              
REMARK   3    ORIGIN FOR THE GROUP (A):   21.0785    7.3127   53.8593           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.3254 T22:   -0.2046                                    
REMARK   3     T33:   -0.2945 T12:   -0.3828                                    
REMARK   3     T13:    0.1579 T23:   -0.2657                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:   10.3050 L22:    0.0000                                    
REMARK   3     L33:    3.9552 L12:    6.3898                                    
REMARK   3     L13:    5.9095 L23:   -0.8668                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.2346 S12:   -0.1032 S13:   -0.2071                     
REMARK   3     S21:    0.3303 S22:    0.5076 S23:   -0.9920                     
REMARK   3     S31:    0.3404 S32:    0.3023 S33:   -0.7422                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: {B|6 - 24}                                             
REMARK   3    ORIGIN FOR THE GROUP (A):    8.7116   11.1983   67.2796           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.6061 T22:   -0.4164                                    
REMARK   3     T33:   -0.3237 T12:   -0.2523                                    
REMARK   3     T13:    0.2799 T23:   -0.1253                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    6.9011 L22:    3.1906                                    
REMARK   3     L33:    7.2817 L12:   -2.2244                                    
REMARK   3     L13:   -5.9440 L23:    3.8187                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.2387 S12:   -0.3071 S13:    0.2990                     
REMARK   3     S21:    0.0207 S22:    0.2916 S23:    0.1939                     
REMARK   3     S31:   -0.4918 S32:    0.5428 S33:   -0.5303                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: {B|25 - 31}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):   15.9451   15.0058   48.2354           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.7328 T22:   -0.2682                                    
REMARK   3     T33:   -0.1760 T12:   -0.4584                                    
REMARK   3     T13:    0.2573 T23:   -0.0196                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.3183 L22:    2.1818                                    
REMARK   3     L33:   -1.3056 L12:    2.8577                                    
REMARK   3     L13:   -7.1784 L23:    3.0103                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.0908 S12:   -0.3060 S13:    1.0422                     
REMARK   3     S21:    0.1925 S22:    0.2577 S23:   -0.5270                     
REMARK   3     S31:   -0.7689 S32:    0.2701 S33:   -0.1669                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: {B|32 - 41}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):    4.0901    1.7918   59.1757           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.1474 T22:   -0.5172                                    
REMARK   3     T33:   -0.5038 T12:    0.0798                                    
REMARK   3     T13:    0.1552 T23:   -0.0196                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.0899 L22:    2.1299                                    
REMARK   3     L33:    5.8379 L12:   -2.0614                                    
REMARK   3     L13:    2.0535 L23:    8.5561                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.1818 S12:   -0.6709 S13:    0.2776                     
REMARK   3     S21:    0.0188 S22:    0.2620 S23:    0.0262                     
REMARK   3     S31:   -1.1006 S32:    0.1742 S33:   -0.0802                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: {B|42 - 50}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):    2.3017    6.3239   52.6808           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.4421 T22:   -0.6130                                    
REMARK   3     T33:   -0.5359 T12:    0.0931                                    
REMARK   3     T13:    0.1168 T23:   -0.0266                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.0038 L22:   10.1073                                    
REMARK   3     L33:   -0.6030 L12:   -0.4000                                    
REMARK   3     L13:   -1.9635 L23:   -4.1011                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.1209 S12:   -0.1183 S13:    0.3041                     
REMARK   3     S21:   -0.8557 S22:    0.4847 S23:   -0.1205                     
REMARK   3     S31:   -1.2462 S32:   -0.4214 S33:   -0.3638                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: {B|51 - 55}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):   -2.3792   11.9594   51.8284           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.5664 T22:   -0.6131                                    
REMARK   3     T33:   -0.2537 T12:    0.2735                                    
REMARK   3     T13:    0.1383 T23:    0.0752                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:   -0.2684 L22:    6.1958                                    
REMARK   3     L33:    3.5982 L12:   -5.0719                                    
REMARK   3     L13:    0.6292 L23:    3.1712                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1581 S12:    0.5931 S13:   -0.1823                     
REMARK   3     S21:   -0.2556 S22:   -0.0220 S23:    0.3989                     
REMARK   3     S31:   -0.9547 S32:   -0.3573 S33:   -0.1361                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: {B|56 - 61}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):   -5.4715   10.5144   59.7100           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.5810 T22:   -0.6901                                    
REMARK   3     T33:   -0.2891 T12:    0.1732                                    
REMARK   3     T13:    0.3746 T23:    0.0601                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    3.6205 L22:    8.2911                                    
REMARK   3     L33:   -0.1632 L12:   -3.5376                                    
REMARK   3     L13:   -6.3542 L23:   -0.1825                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1859 S12:   -0.0038 S13:   -0.0544                     
REMARK   3     S21:    0.1457 S22:   -0.1556 S23:    0.2532                     
REMARK   3     S31:   -0.5404 S32:   -0.9258 S33:   -0.0304                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: {B|62 - 74}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):    8.2776   15.8846   57.8304           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.8423 T22:   -0.7511                                    
REMARK   3     T33:   -0.5208 T12:   -0.1554                                    
REMARK   3     T13:    0.3568 T23:   -0.1548                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    4.2686 L22:    7.3236                                    
REMARK   3     L33:    1.8997 L12:   -4.7619                                    
REMARK   3     L13:    2.9087 L23:    0.3598                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.3189 S12:    0.1287 S13:    0.0795                     
REMARK   3     S21:    0.6583 S22:   -0.0131 S23:    0.1973                     
REMARK   3     S31:   -0.9270 S32:    0.9068 S33:   -0.3058                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: {B|75 - 85}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):   -0.0633    6.6627   67.0567           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.2435 T22:   -0.7347                                    
REMARK   3     T33:   -0.5439 T12:   -0.0001                                    
REMARK   3     T13:    0.0543 T23:   -0.0134                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.7238 L22:   10.4949                                    
REMARK   3     L33:   15.9918 L12:   -7.6141                                    
REMARK   3     L13:   -5.4458 L23:    7.0843                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.3217 S12:   -0.1848 S13:    0.2172                     
REMARK   3     S21:   -0.3756 S22:    0.2172 S23:    0.3427                     
REMARK   3     S31:   -0.2674 S32:   -0.2772 S33:   -0.5389                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: {B|86 - 102}                                           
REMARK   3    ORIGIN FOR THE GROUP (A):   14.9492    4.3473   51.0815           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.1723 T22:   -0.4269                                    
REMARK   3     T33:   -0.4923 T12:   -0.2193                                    
REMARK   3     T13:    0.1569 T23:   -0.0772                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.5117 L22:    1.6265                                    
REMARK   3     L33:    0.2427 L12:    2.1990                                    
REMARK   3     L13:    0.9249 L23:    0.7595                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.1448 S12:   -0.0119 S13:    0.2946                     
REMARK   3     S21:    0.0186 S22:    0.2735 S23:   -0.0820                     
REMARK   3     S31:   -1.2145 S32:    0.8188 S33:   -0.1286                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: {B|103 - 108}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    4.4636    5.5543   74.5962           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.3159 T22:   -0.3960                                    
REMARK   3     T33:   -0.3382 T12:   -0.0264                                    
REMARK   3     T13:    0.1388 T23:   -0.0837                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:   -0.3261 L22:    2.2072                                    
REMARK   3     L33:    0.4485 L12:    5.5972                                    
REMARK   3     L13:    1.0575 L23:   -0.8763                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0723 S12:    0.3293 S13:    0.3485                     
REMARK   3     S21:   -0.1944 S22:    0.0003 S23:    0.6275                     
REMARK   3     S31:   -0.6375 S32:   -0.0219 S33:   -0.0726                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: {B|109 - 119}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    1.4004   -9.6238   87.7622           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.3350 T22:   -0.3227                                    
REMARK   3     T33:   -0.4708 T12:   -0.1751                                    
REMARK   3     T13:    0.0430 T23:   -0.0527                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.2168 L22:    0.0000                                    
REMARK   3     L33:    8.2904 L12:   -0.6030                                    
REMARK   3     L13:   -1.3843 L23:    0.7782                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.5400 S12:   -0.5009 S13:   -0.0151                     
REMARK   3     S21:    0.5324 S22:   -0.4792 S23:    0.4836                     
REMARK   3     S31:   -0.8035 S32:    0.1761 S33:   -0.0609                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: {B|120 - 141}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    4.8536  -20.1285   83.4373           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.3586 T22:   -0.2726                                    
REMARK   3     T33:   -0.4144 T12:   -0.0602                                    
REMARK   3     T13:   -0.0385 T23:    0.0161                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.1394 L22:    1.5341                                    
REMARK   3     L33:    5.0206 L12:    0.8079                                    
REMARK   3     L13:   -0.8344 L23:    0.5522                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1129 S12:   -0.2207 S13:   -0.2234                     
REMARK   3     S21:    0.5178 S22:   -0.1900 S23:    0.2154                     
REMARK   3     S31:    0.2213 S32:    0.5390 S33:    0.0770                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: {B|142 - 146}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):   11.5821   -4.9736   84.2274           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.0389 T22:    0.0157                                    
REMARK   3     T33:   -0.3666 T12:   -0.3144                                    
REMARK   3     T13:    0.0582 T23:   -0.0258                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    9.4978 L22:   13.0375                                    
REMARK   3     L33:    5.0330 L12:   -5.2912                                    
REMARK   3     L13:    2.8658 L23:   -6.5989                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.3531 S12:    0.1131 S13:    0.2651                     
REMARK   3     S21:   -0.5624 S22:   -0.1981 S23:   -0.4452                     
REMARK   3     S31:   -0.6169 S32:    0.8912 S33:   -0.1549                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: {B|147 - 154}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):   14.2868  -18.1722   94.3319           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.1624 T22:    0.2616                                    
REMARK   3     T33:   -0.2767 T12:   -0.2006                                    
REMARK   3     T13:   -0.0938 T23:    0.0725                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    4.4428 L22:    0.0000                                    
REMARK   3     L33:   10.6800 L12:   -4.4336                                    
REMARK   3     L13:    6.1471 L23:    3.9735                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.0551 S12:   -0.6297 S13:    0.0402                     
REMARK   3     S21:    0.4232 S22:    0.2796 S23:   -0.0531                     
REMARK   3     S31:    0.5559 S32:    0.8704 S33:   -0.2245                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: {B|155 - 162}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):   15.5760  -16.9692   83.5610           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.2091 T22:    0.2581                                    
REMARK   3     T33:   -0.2756 T12:   -0.1649                                    
REMARK   3     T13:   -0.0142 T23:    0.0315                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:   -1.8179 L22:    0.0000                                    
REMARK   3     L33:   11.2252 L12:    1.1840                                    
REMARK   3     L13:    5.2433 L23:    1.8246                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.3708 S12:   -0.1965 S13:    0.0603                     
REMARK   3     S21:    0.1421 S22:   -0.3713 S23:   -0.0626                     
REMARK   3     S31:   -0.3780 S32:    1.0420 S33:    0.0005                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: {B|163 - 184}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    5.4013  -11.3929   79.6131           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.1235 T22:   -0.1410                                    
REMARK   3     T33:   -0.3117 T12:   -0.1018                                    
REMARK   3     T13:   -0.0053 T23:   -0.0180                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.7781 L22:   12.6393                                    
REMARK   3     L33:    4.2005 L12:   -3.2727                                    
REMARK   3     L13:    0.6674 L23:   -2.7525                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.3322 S12:   -0.1897 S13:   -0.0106                     
REMARK   3     S21:   -0.2188 S22:   -0.2288 S23:    0.0595                     
REMARK   3     S31:   -0.4470 S32:    0.4418 S33:   -0.1034                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: {B|185 - 190}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):   12.2645  -30.5670   93.2555           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.2370 T22:    0.2079                                    
REMARK   3     T33:   -0.2151 T12:   -0.0251                                    
REMARK   3     T13:   -0.1951 T23:    0.2035                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    3.0267 L22:    5.2075                                    
REMARK   3     L33:    0.8614 L12:    1.8124                                    
REMARK   3     L13:   -3.1265 L23:   -6.6418                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.2903 S12:   -0.1505 S13:   -0.4372                     
REMARK   3     S21:    1.1502 S22:   -0.5537 S23:   -0.2143                     
REMARK   3     S31:    0.5917 S32:    1.1952 S33:    0.2635                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: {B|191 - 208}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    7.5421   -9.8013   93.6905           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0001 T22:    0.0048                                    
REMARK   3     T33:   -0.3857 T12:   -0.3396                                    
REMARK   3     T13:   -0.0257 T23:   -0.0198                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.9270 L22:    1.1076                                    
REMARK   3     L33:    6.4425 L12:   -2.0690                                    
REMARK   3     L13:   -0.2190 L23:   -1.5814                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.2746 S12:   -0.6233 S13:    0.1171                     
REMARK   3     S21:    0.8220 S22:   -0.0265 S23:    0.0486                     
REMARK   3     S31:   -0.7123 S32:    0.6016 S33:   -0.2481                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: {B|209 - 212}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    4.7883  -26.8574   95.1550           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.0178 T22:   -0.0937                                    
REMARK   3     T33:   -0.3198 T12:   -0.2283                                    
REMARK   3     T13:   -0.1088 T23:    0.1748                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    7.0670 L22:    2.7833                                    
REMARK   3     L33:   -1.4667 L12:   -0.2894                                    
REMARK   3     L13:   -4.6623 L23:   -4.9673                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0302 S12:   -0.7882 S13:   -0.7076                     
REMARK   3     S21:    0.2450 S22:   -0.0618 S23:    1.1072                     
REMARK   3     S31:   -0.2819 S32:    0.5126 S33:    0.0316                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: {E|1 - 9}                                              
REMARK   3    ORIGIN FOR THE GROUP (A):   -2.2379  -11.5132   48.5388           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.1102 T22:   -0.1047                                    
REMARK   3     T33:   -0.1257 T12:   -0.0079                                    
REMARK   3     T13:    0.0945 T23:   -0.0105                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    3.1659 L22:   12.1403                                    
REMARK   3     L33:    1.8689 L12:    2.9427                                    
REMARK   3     L13:   -5.7393 L23:    6.4286                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.1089 S12:   -0.1090 S13:   -0.0743                     
REMARK   3     S21:    0.9590 S22:   -0.5648 S23:    0.6810                     
REMARK   3     S31:   -0.3157 S32:   -0.4847 S33:    0.6737                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: {E|10 - 18}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):   16.8289  -23.7817   52.1055           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.1333 T22:   -0.1320                                    
REMARK   3     T33:   -0.1445 T12:    0.0999                                    
REMARK   3     T13:    0.0021 T23:   -0.0251                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.6539 L22:    0.0000                                    
REMARK   3     L33:    7.3373 L12:    6.1344                                    
REMARK   3     L13:   -6.0817 L23:   -5.5767                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.3398 S12:    0.4741 S13:   -1.0008                     
REMARK   3     S21:   -0.1251 S22:   -0.1447 S23:   -0.3144                     
REMARK   3     S31:    0.2131 S32:    0.6366 S33:   -0.1951                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: {E|19 - 29}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):    0.1649  -10.8032   42.1055           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.1344 T22:   -0.0741                                    
REMARK   3     T33:   -0.1316 T12:   -0.0223                                    
REMARK   3     T13:   -0.0126 T23:   -0.0055                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:   13.1385 L22:    8.3493                                    
REMARK   3     L33:    6.5219 L12:   -8.0912                                    
REMARK   3     L13:    4.1570 L23:   -2.1808                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.4338 S12:   -0.3924 S13:   -0.3049                     
REMARK   3     S21:   -0.1137 S22:    0.6053 S23:    0.5834                     
REMARK   3     S31:   -0.3301 S32:   -0.5963 S33:   -0.1715                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: {E|30 - 38}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):    4.9061   -5.2841   41.6086           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.1093 T22:   -0.0817                                    
REMARK   3     T33:   -0.1813 T12:   -0.0023                                    
REMARK   3     T13:   -0.0044 T23:    0.0239                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    0.0100 L22:    0.0000                                    
REMARK   3     L33:    2.5563 L12:    1.7162                                    
REMARK   3     L13:   -0.2243 L23:    1.0099                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.2232 S12:    0.1338 S13:   -0.1761                     
REMARK   3     S21:   -0.1517 S22:    0.3190 S23:    0.2256                     
REMARK   3     S31:   -1.0903 S32:   -0.2142 S33:   -0.0958                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    SELECTION: {E|39 - 45}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):   13.4926   -6.3254   60.2682           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.3399 T22:    0.0356                                    
REMARK   3     T33:   -0.2520 T12:   -0.0128                                    
REMARK   3     T13:    0.0423 T23:   -0.0553                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.0379 L22:    7.2655                                    
REMARK   3     L33:    1.5727 L12:    6.4172                                    
REMARK   3     L13:    5.4137 L23:    4.7754                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0012 S12:   -0.0762 S13:   -0.2277                     
REMARK   3     S21:    1.1005 S22:    0.1846 S23:   -0.2412                     
REMARK   3     S31:    0.2057 S32:    0.8411 S33:   -0.1858                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    SELECTION: {E|46 - 63}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):   13.7475   -5.1459   40.6548           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.0210 T22:   -0.1466                                    
REMARK   3     T33:   -0.3466 T12:   -0.1694                                    
REMARK   3     T13:    0.0185 T23:   -0.0208                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.3524 L22:    3.8293                                    
REMARK   3     L33:    8.0956 L12:   -0.4054                                    
REMARK   3     L13:   -2.6946 L23:    0.7297                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.1040 S12:    0.1181 S13:   -0.0531                     
REMARK   3     S21:   -0.1539 S22:    0.3282 S23:   -0.0995                     
REMARK   3     S31:   -1.0383 S32:    0.5279 S33:   -0.2242                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    SELECTION: {E|64 - 73}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):   14.3955  -12.1323   41.2782           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.2893 T22:   -0.1709                                    
REMARK   3     T33:   -0.3920 T12:   -0.0624                                    
REMARK   3     T13:    0.0514 T23:   -0.0358                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.8415 L22:    5.1005                                    
REMARK   3     L33:    7.3484 L12:   -6.1647                                    
REMARK   3     L13:   -0.8976 L23:   -1.8578                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.2806 S12:    0.8094 S13:   -0.4507                     
REMARK   3     S21:   -0.2519 S22:   -0.1050 S23:   -0.0497                     
REMARK   3     S31:    0.0075 S32:    1.1788 S33:   -0.1756                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    SELECTION: {E|74 - 82}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):    4.0458  -14.2049   38.8787           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0561 T22:   -0.1242                                    
REMARK   3     T33:   -0.1035 T12:   -0.0446                                    
REMARK   3     T13:   -0.0433 T23:   -0.0398                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.2720 L22:    0.0000                                    
REMARK   3     L33:    4.6973 L12:    1.0122                                    
REMARK   3     L13:    1.2164 L23:    1.9303                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0621 S12:    0.9677 S13:   -0.3285                     
REMARK   3     S21:   -0.0556 S22:   -0.0592 S23:    0.3991                     
REMARK   3     S31:    0.1149 S32:    0.5038 S33:   -0.0029                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    SELECTION: {E|83 - 97}                                            
REMARK   3    ORIGIN FOR THE GROUP (A):   14.8059  -13.8537   52.1995           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0665 T22:   -0.0216                                    
REMARK   3     T33:   -0.2072 T12:   -0.0021                                    
REMARK   3     T13:    0.0534 T23:   -0.0153                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    5.5925 L22:    9.7180                                    
REMARK   3     L33:    6.8701 L12:   -5.0000                                    
REMARK   3     L13:   -1.8170 L23:    0.9485                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.2560 S12:   -0.0270 S13:   -0.0128                     
REMARK   3     S21:    0.5272 S22:    0.1968 S23:   -0.2304                     
REMARK   3     S31:   -0.2875 S32:    0.7483 S33:    0.0592                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    SELECTION: {E|98 - 107}                                           
REMARK   3    ORIGIN FOR THE GROUP (A):    6.7959    7.4317   38.9337           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.7501 T22:   -0.1201                                    
REMARK   3     T33:   -0.3198 T12:    0.1221                                    
REMARK   3     T13:    0.0343 T23:    0.0616                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.8081 L22:    2.6560                                    
REMARK   3     L33:    2.1838 L12:   -6.2593                                    
REMARK   3     L13:    4.1082 L23:   -1.6569                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1717 S12:    1.0246 S13:   -0.1749                     
REMARK   3     S21:   -0.4224 S22:   -0.1280 S23:   -0.5845                     
REMARK   3     S31:   -0.9004 S32:   -0.6701 S33:   -0.0437                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    SELECTION: {E|108 - 113}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):   11.6082    9.6769   42.1247           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.7567 T22:   -0.2426                                    
REMARK   3     T33:    0.0285 T12:   -0.2691                                    
REMARK   3     T13:    0.2158 T23:    0.0754                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    4.1876 L22:    4.3299                                    
REMARK   3     L33:   -0.7726 L12:   -2.1007                                    
REMARK   3     L13:   -2.2739 L23:    0.7027                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.3806 S12:   -0.1233 S13:    1.1879                     
REMARK   3     S21:   -0.0020 S22:    0.3090 S23:   -0.9553                     
REMARK   3     S31:   -1.3119 S32:    0.7937 S33:    0.0716                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    SELECTION: {E|114 - 119}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    1.3428   -3.2751   50.5829           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0202 T22:   -0.2822                                    
REMARK   3     T33:   -0.3196 T12:    0.1294                                    
REMARK   3     T13:    0.0744 T23:    0.0618                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    9.1948 L22:    9.4995                                    
REMARK   3     L33:    6.0377 L12:    0.9353                                    
REMARK   3     L13:    0.1529 L23:    7.2177                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.0884 S12:   -0.3801 S13:    0.0671                     
REMARK   3     S21:    0.1165 S22:   -0.1614 S23:    0.6233                     
REMARK   3     S31:   -1.0355 S32:   -0.5332 S33:    0.2498                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    SELECTION: {E|120 - 133}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):   11.7334  -23.1044   60.4350           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.1094 T22:   -0.1774                                    
REMARK   3     T33:   -0.2495 T12:    0.1117                                    
REMARK   3     T13:    0.0414 T23:   -0.0019                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:   -0.0419 L22:    2.0380                                    
REMARK   3     L33:    3.2944 L12:    3.6624                                    
REMARK   3     L13:   -0.1059 L23:   -3.4253                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1883 S12:    0.2119 S13:   -0.2095                     
REMARK   3     S21:    0.5585 S22:   -0.1510 S23:   -0.0928                     
REMARK   3     S31:    0.3390 S32:    0.4671 S33:   -0.0373                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    SELECTION: {E|134 - 160}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    1.1444  -22.6688   79.0500           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.2061 T22:   -0.1867                                    
REMARK   3     T33:   -0.2564 T12:   -0.0499                                    
REMARK   3     T13:   -0.0848 T23:   -0.0169                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    3.8780 L22:    6.1132                                    
REMARK   3     L33:    3.6630 L12:   -3.0710                                    
REMARK   3     L13:   -2.3890 L23:    1.1198                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.0518 S12:   -0.5520 S13:   -0.2978                     
REMARK   3     S21:   -0.0817 S22:    0.0216 S23:    0.6490                     
REMARK   3     S31:    0.4690 S32:    0.3272 S33:    0.0302                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    SELECTION: {E|161 - 166}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    3.9688  -19.6896   65.4866           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.2038 T22:   -0.2929                                    
REMARK   3     T33:   -0.2597 T12:    0.1014                                    
REMARK   3     T13:   -0.0590 T23:    0.0134                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.6742 L22:    0.0000                                    
REMARK   3     L33:    9.2843 L12:    3.4568                                    
REMARK   3     L13:   -5.2392 L23:    2.3674                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.2855 S12:    0.0207 S13:    0.9580                     
REMARK   3     S21:   -1.0744 S22:    0.2540 S23:    0.1520                     
REMARK   3     S31:    0.4758 S32:   -0.0892 S33:    0.0315                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    SELECTION: {E|167 - 176}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -10.2948  -16.0962   73.4636           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.2825 T22:   -0.0793                                    
REMARK   3     T33:   -0.1169 T12:    0.0258                                    
REMARK   3     T13:   -0.1261 T23:   -0.0549                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:   10.1003 L22:    0.0000                                    
REMARK   3     L33:    9.7584 L12:    8.3426                                    
REMARK   3     L13:    2.5414 L23:   -1.6154                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.2589 S12:    0.4454 S13:    0.3040                     
REMARK   3     S21:    0.3367 S22:    0.1795 S23:    0.2140                     
REMARK   3     S31:   -0.2069 S32:   -1.1277 S33:    0.0795                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    SELECTION: {E|177 - 201}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    3.5994  -17.2615   76.2141           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.2513 T22:   -0.2606                                    
REMARK   3     T33:   -0.3558 T12:   -0.0249                                    
REMARK   3     T13:   -0.0717 T23:   -0.0425                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.3546 L22:    4.1230                                    
REMARK   3     L33:    3.3512 L12:   -0.2972                                    
REMARK   3     L13:    0.5943 L23:   -1.5489                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.5068 S12:   -0.4535 S13:    0.1611                     
REMARK   3     S21:   -0.5397 S22:   -0.2025 S23:    0.0807                     
REMARK   3     S31:   -0.1912 S32:    0.3381 S33:   -0.3043                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    SELECTION: {E|202 - 214}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):   -9.3940  -22.3488   76.7120           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.2942 T22:   -0.3291                                    
REMARK   3     T33:   -0.1699 T12:   -0.1377                                    
REMARK   3     T13:   -0.1279 T23:   -0.0226                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.7616 L22:    4.8450                                    
REMARK   3     L33:    1.0809 L12:   -2.9589                                    
REMARK   3     L13:    3.8227 L23:   -0.9459                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0522 S12:   -0.0018 S13:   -0.6818                     
REMARK   3     S21:    0.0753 S22:   -0.1035 S23:    1.0749                     
REMARK   3     S31:    0.6981 S32:   -1.1927 S33:    0.0513                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    SELECTION: {E|215 - 220}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    0.5576  -27.0368   61.8833           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.0599 T22:   -0.4279                                    
REMARK   3     T33:   -0.3928 T12:    0.0890                                    
REMARK   3     T13:   -0.1279 T23:   -0.1307                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:   10.1422 L22:    1.2094                                    
REMARK   3     L33:    0.6047 L12:   -3.7266                                    
REMARK   3     L13:   -6.8448 L23:   -9.4552                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.1550 S12:    0.6281 S13:   -0.7230                     
REMARK   3     S21:   -1.0303 S22:   -0.4539 S23:    0.4876                     
REMARK   3     S31:    0.6101 S32:   -0.3699 S33:    0.6089                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    SELECTION: {E|221 - 227}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):   -7.1240  -27.1038   78.4953           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.5213 T22:   -0.5773                                    
REMARK   3     T33:   -0.2976 T12:   -0.1074                                    
REMARK   3     T13:   -0.0696 T23:   -0.0509                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:   -1.3660 L22:   15.5052                                    
REMARK   3     L33:    6.4355 L12:   -1.0813                                    
REMARK   3     L13:    4.0891 L23:   -4.1471                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0724 S12:   -0.2884 S13:   -0.6186                     
REMARK   3     S21:    0.1861 S22:    0.0238 S23:    0.4431                     
REMARK   3     S31:    0.1388 S32:   -0.0996 S33:   -0.0962                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    SELECTION: {A|415 - 423}                                          
REMARK   3    ORIGIN FOR THE GROUP (A):    9.2940    3.5721   35.3054           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.5095 T22:   -0.2237                                    
REMARK   3     T33:   -0.3624 T12:   -0.0807                                    
REMARK   3     T13:    0.1382 T23:    0.1030                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.1034 L22:    7.1334                                    
REMARK   3     L33:   13.5667 L12:   -6.4101                                    
REMARK   3     L13:    4.4104 L23:   -4.6722                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1522 S12:    0.4197 S13:    1.0333                     
REMARK   3     S21:   -0.8263 S22:    0.2806 S23:   -0.2287                     
REMARK   3     S31:   -1.0277 S32:   -1.0914 S33:   -0.4328                     
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 5FGC COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 20-DEC-15.                  
REMARK 100 THE DEPOSITION ID IS D_1000216549.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 06-JUN-14                          
REMARK 200  TEMPERATURE           (KELVIN) : 110                                
REMARK 200  PH                             : 8.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : NULL                               
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : SLS                                
REMARK 200  BEAMLINE                       : X06SA                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.00002                            
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M                 
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XDS                                
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 33283                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.900                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.7                               
REMARK 200  DATA REDUNDANCY                : 6.700                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 16.3900                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.90                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.02                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 97.8                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 6.70                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 1.210                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: PDB                                                  
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 37.70                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.97                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 32% PEG 4000 100 MM TRIS-HCL PH 8.5      
REMARK 280  800 MM LITHIUM CHLORIDE CRYSTALS OBTAINED USING HETEROLOGOUS        
REMARK 280  MICROSEEDING., VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K      
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 2 1                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y,-Z                                                 
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5250 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 20130 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -35.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, E                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     PRO A   405                                                      
REMARK 465     GLY A   406                                                      
REMARK 465     ALA A   407                                                      
REMARK 465     LYS A   408                                                      
REMARK 465     GLN A   409                                                      
REMARK 465     ASN A   410                                                      
REMARK 465     ILE A   411                                                      
REMARK 465     GLN A   412                                                      
REMARK 465     LEU A   413                                                      
REMARK 465     ILE A   414                                                      
REMARK 465     SER A   424                                                      
REMARK 465     THR A   425                                                      
REMARK 465     ARG B    -1                                                      
REMARK 465     SER B     0                                                      
REMARK 465     SER E   142                                                      
REMARK 465     LYS E   143                                                      
REMARK 465     SER E   144                                                      
REMARK 465     THR E   145                                                      
REMARK 465     SER E   146                                                      
REMARK 465     ASP E   231                                                      
REMARK 465     LYS E   232                                                      
REMARK 465     LEU E   233                                                      
REMARK 465     GLU E   234                                                      
REMARK 465     ASP E   235                                                      
REMARK 465     ASP E   236                                                      
REMARK 465     ASP E   237                                                      
REMARK 465     ASP E   238                                                      
REMARK 465     LYS E   239                                                      
REMARK 465     ALA E   240                                                      
REMARK 465     GLY E   241                                                      
REMARK 465     TRP E   242                                                      
REMARK 465     SER E   243                                                      
REMARK 465     HIS E   244                                                      
REMARK 465     PRO E   245                                                      
REMARK 465     GLN E   246                                                      
REMARK 465     PHE E   247                                                      
REMARK 465     GLU E   248                                                      
REMARK 465     LYS E   249                                                      
REMARK 465     GLY E   250                                                      
REMARK 465     GLY E   251                                                      
REMARK 465     GLY E   252                                                      
REMARK 465     SER E   253                                                      
REMARK 465     GLY E   254                                                      
REMARK 465     GLY E   255                                                      
REMARK 465     GLY E   256                                                      
REMARK 465     SER E   257                                                      
REMARK 465     GLY E   258                                                      
REMARK 465     GLY E   259                                                      
REMARK 465     GLY E   260                                                      
REMARK 465     SER E   261                                                      
REMARK 465     TRP E   262                                                      
REMARK 465     SER E   263                                                      
REMARK 465     HIS E   264                                                      
REMARK 465     PRO E   265                                                      
REMARK 465     GLN E   266                                                      
REMARK 465     PHE E   267                                                      
REMARK 465     GLU E   268                                                      
REMARK 465     LYS E   269                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASP B  50      -53.11     71.11                                   
REMARK 500    ASP B  95     -131.01     65.49                                   
REMARK 500    GLU B 213       73.51     -8.32                                   
REMARK 500    THR E 103      102.20    -34.36                                   
REMARK 500    ALA E 107     -147.05    -85.01                                   
REMARK 500    TYR E 108      -27.25     67.85                                   
REMARK 500    ASP E 158       67.05     61.87                                   
REMARK 500    THR E 205      -44.18   -136.96                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 5FGB   RELATED DB: PDB                                   
REMARK 900 5FGB CONTAINS A RELATED FAB FRAGMENT CRYSTALLIZED WITH THE SAME      
REMARK 900 PEPTIDE                                                              
DBREF  5FGC A  405   425  UNP    P27958   POLG_HCVH      405    425             
DBREF  5FGC B   -1   214  PDB    5FGC     5FGC            -1    214             
DBREF  5FGC E    1   269  PDB    5FGC     5FGC             1    269             
SEQRES   1 A   21  PRO GLY ALA LYS GLN ASN ILE GLN LEU ILE ASN THR ASN          
SEQRES   2 A   21  GLY SER TRP HIS ILE ASN SER THR                              
SEQRES   1 B  216  ARG SER SER TYR GLU LEU THR GLN PRO PRO SER VAL SER          
SEQRES   2 B  216  VAL SER PRO GLY GLN ALA ALA THR ILE THR CYS SER GLY          
SEQRES   3 B  216  ASP LYS LEU GLY ASP LYS TYR VAL SER TRP TYR GLN GLN          
SEQRES   4 B  216  ARG PRO GLY GLN SER PRO LEU LEU VAL VAL TYR GLN ASP          
SEQRES   5 B  216  ASN LYS ARG PRO SER GLY ILE PRO GLU ARG ILE SER GLY          
SEQRES   6 B  216  SER ASN SER GLY ASN THR ALA THR LEU THR ILE ARG GLY          
SEQRES   7 B  216  THR ARG ALA MET ASP GLU ALA ASP TYR TYR CYS GLN ALA          
SEQRES   8 B  216  TRP ASP SER SER THR ASP VAL VAL PHE GLY GLY GLY THR          
SEQRES   9 B  216  LYS LEU THR VAL LEU ARG THR VAL ALA ALA PRO SER VAL          
SEQRES  10 B  216  PHE ILE PHE PRO PRO SER ASP GLU GLN LEU LYS SER GLY          
SEQRES  11 B  216  THR ALA SER VAL VAL CYS LEU LEU ASN ASN PHE TYR PRO          
SEQRES  12 B  216  ARG GLU ALA LYS VAL GLN TRP LYS VAL ASP ASN ALA LEU          
SEQRES  13 B  216  GLN SER GLY ASN SER GLN GLU SER VAL THR GLU GLN ASP          
SEQRES  14 B  216  SER LYS ASP SER THR TYR SER LEU SER SER THR LEU THR          
SEQRES  15 B  216  LEU SER LYS ALA ASP TYR GLU LYS HIS LYS VAL TYR ALA          
SEQRES  16 B  216  CYS GLU VAL THR HIS GLN GLY LEU SER SER PRO VAL THR          
SEQRES  17 B  216  LYS SER PHE ASN ARG GLY GLU CYS                              
SEQRES   1 E  269  GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU ALA GLN          
SEQRES   2 E  269  PRO GLY GLU SER LEU ARG LEU SER CYS ALA ALA SER GLY          
SEQRES   3 E  269  PHE ASN PHE TYR THR TYR ALA MET THR TRP VAL ARG GLN          
SEQRES   4 E  269  ALA PRO GLY LYS GLY LEU GLU TRP VAL SER ALA SER SER          
SEQRES   5 E  269  SER THR ASP GLY THR THR TYR TYR ALA ASP SER VAL LYS          
SEQRES   6 E  269  GLY ARG PHE THR ILE SER ARG ASP ASN SER LYS ASN ILE          
SEQRES   7 E  269  LEU TYR LEU GLN MET ASN SER LEU LYS ALA GLU ASP THR          
SEQRES   8 E  269  ALA THR TYR TYR CYS ALA ARG ALA VAL VAL PHE THR ASP          
SEQRES   9 E  269  SER SER ALA TYR TYR TYR SER LYS TYR PHE ASP TYR TRP          
SEQRES  10 E  269  SER GLN GLY THR LEU VAL THR VAL SER SER ALA SER THR          
SEQRES  11 E  269  LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER SER LYS          
SEQRES  12 E  269  SER THR SER GLY GLY THR ALA ALA LEU GLY CYS LEU VAL          
SEQRES  13 E  269  LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER TRP ASN          
SEQRES  14 E  269  SER GLY ALA LEU THR SER GLY VAL HIS THR PHE PRO ALA          
SEQRES  15 E  269  VAL LEU GLN SER SER GLY LEU TYR SER LEU SER SER VAL          
SEQRES  16 E  269  VAL THR VAL PRO SER SER SER LEU GLY THR GLN THR TYR          
SEQRES  17 E  269  ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR LYS VAL          
SEQRES  18 E  269  ASP LYS LYS ALA GLU PRO LYS SER CYS ASP LYS LEU GLU          
SEQRES  19 E  269  ASP ASP ASP ASP LYS ALA GLY TRP SER HIS PRO GLN PHE          
SEQRES  20 E  269  GLU LYS GLY GLY GLY SER GLY GLY GLY SER GLY GLY GLY          
SEQRES  21 E  269  SER TRP SER HIS PRO GLN PHE GLU LYS                          
FORMUL   4  HOH   *116(H2 O)                                                    
HELIX    1 AA1 LYS B   26  LYS B   30  5                                   5    
HELIX    2 AA2 ARG B   78  GLU B   82  5                                   5    
HELIX    3 AA3 SER B  121  LYS B  126  1                                   6    
HELIX    4 AA4 LYS B  183  LYS B  188  1                                   6    
HELIX    5 AA5 ASN E   28  TYR E   32  5                                   5    
HELIX    6 AA6 LYS E   87  THR E   91  5                                   5    
HELIX    7 AA7 SER E  170  ALA E  172  5                                   3    
HELIX    8 AA8 SER E  201  LEU E  203  5                                   3    
HELIX    9 AA9 LYS E  215  ASN E  218  5                                   4    
SHEET    1 AA1 5 SER B   9  VAL B  12  0                                        
SHEET    2 AA1 5 THR B 102  VAL B 106  1  O  THR B 105   N  VAL B  10           
SHEET    3 AA1 5 ASP B  84  ASP B  91 -1  N  TYR B  85   O  THR B 102           
SHEET    4 AA1 5 SER B  33  GLN B  37 -1  N  GLN B  37   O  ASP B  84           
SHEET    5 AA1 5 LEU B  44  VAL B  47 -1  O  LEU B  44   N  GLN B  36           
SHEET    1 AA2 4 SER B   9  VAL B  12  0                                        
SHEET    2 AA2 4 THR B 102  VAL B 106  1  O  THR B 105   N  VAL B  10           
SHEET    3 AA2 4 ASP B  84  ASP B  91 -1  N  TYR B  85   O  THR B 102           
SHEET    4 AA2 4 ASP B  95  PHE B  98 -1  O  ASP B  95   N  ASP B  91           
SHEET    1 AA3 3 ALA B  18  SER B  23  0                                        
SHEET    2 AA3 3 THR B  69  ILE B  74 -1  O  LEU B  72   N  ILE B  20           
SHEET    3 AA3 3 ILE B  61  SER B  66 -1  N  SER B  64   O  THR B  71           
SHEET    1 AA4 4 SER B 114  PHE B 118  0                                        
SHEET    2 AA4 4 THR B 129  PHE B 139 -1  O  LEU B 135   N  PHE B 116           
SHEET    3 AA4 4 TYR B 173  SER B 182 -1  O  LEU B 181   N  ALA B 130           
SHEET    4 AA4 4 SER B 159  VAL B 163 -1  N  GLN B 160   O  THR B 178           
SHEET    1 AA5 4 ALA B 153  GLN B 155  0                                        
SHEET    2 AA5 4 LYS B 145  VAL B 150 -1  N  TRP B 148   O  GLN B 155           
SHEET    3 AA5 4 VAL B 191  THR B 197 -1  O  GLU B 195   N  GLN B 147           
SHEET    4 AA5 4 VAL B 205  ASN B 210 -1  O  VAL B 205   N  VAL B 196           
SHEET    1 AA6 4 GLN E   3  GLY E   8  0                                        
SHEET    2 AA6 4 LEU E  18  SER E  25 -1  O  ALA E  23   N  VAL E   5           
SHEET    3 AA6 4 ILE E  78  MET E  83 -1  O  LEU E  81   N  LEU E  20           
SHEET    4 AA6 4 PHE E  68  ASP E  73 -1  N  SER E  71   O  TYR E  80           
SHEET    1 AA7 6 GLY E  10  ALA E  12  0                                        
SHEET    2 AA7 6 THR E 121  VAL E 125  1  O  THR E 124   N  GLY E  10           
SHEET    3 AA7 6 ALA E  92  VAL E 101 -1  N  TYR E  94   O  THR E 121           
SHEET    4 AA7 6 ALA E  33  GLN E  39 -1  N  VAL E  37   O  TYR E  95           
SHEET    5 AA7 6 LEU E  45  SER E  51 -1  O  GLU E  46   N  ARG E  38           
SHEET    6 AA7 6 THR E  58  TYR E  60 -1  O  TYR E  59   N  ALA E  50           
SHEET    1 AA8 4 GLY E  10  ALA E  12  0                                        
SHEET    2 AA8 4 THR E 121  VAL E 125  1  O  THR E 124   N  GLY E  10           
SHEET    3 AA8 4 ALA E  92  VAL E 101 -1  N  TYR E  94   O  THR E 121           
SHEET    4 AA8 4 LYS E 112  TRP E 117 -1  O  TYR E 113   N  VAL E 100           
SHEET    1 AA9 4 SER E 134  LEU E 138  0                                        
SHEET    2 AA9 4 THR E 149  TYR E 159 -1  O  GLY E 153   N  LEU E 138           
SHEET    3 AA9 4 TYR E 190  PRO E 199 -1  O  VAL E 198   N  ALA E 150           
SHEET    4 AA9 4 HIS E 178  THR E 179 -1  N  HIS E 178   O  VAL E 195           
SHEET    1 AB1 4 SER E 134  LEU E 138  0                                        
SHEET    2 AB1 4 THR E 149  TYR E 159 -1  O  GLY E 153   N  LEU E 138           
SHEET    3 AB1 4 TYR E 190  PRO E 199 -1  O  VAL E 198   N  ALA E 150           
SHEET    4 AB1 4 VAL E 183  LEU E 184 -1  N  VAL E 183   O  SER E 191           
SHEET    1 AB2 3 THR E 165  TRP E 168  0                                        
SHEET    2 AB2 3 ILE E 209  HIS E 214 -1  O  ASN E 211   N  SER E 167           
SHEET    3 AB2 3 THR E 219  LYS E 224 -1  O  VAL E 221   N  VAL E 212           
SSBOND   1 CYS B   22    CYS B   87                          1555   1555  2.04  
SSBOND   2 CYS B  134    CYS B  194                          1555   1555  2.07  
SSBOND   3 CYS B  214    CYS E  230                          1555   1555  2.04  
SSBOND   4 CYS E   22    CYS E   96                          1555   1555  2.04  
SSBOND   5 CYS E  154    CYS E  210                          1555   1555  2.02  
CISPEP   1 TYR B  140    PRO B  141          0         1.18                     
CISPEP   2 PHE E  160    PRO E  161          0        -5.98                     
CISPEP   3 GLU E  162    PRO E  163          0         7.92                     
CRYST1   66.050   49.570   66.390  90.00  98.50  90.00 P 1 2 1       2          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.015140  0.000000  0.002263        0.00000                         
SCALE2      0.000000  0.020173  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.015230        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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