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Entry: 5FJ4
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HEADER    TRANSCRIPTION                           06-OCT-15   5FJ4              
TITLE     STRUCTURE OF THE STANDARD KINK TURN HMKT-7 AS STEM LOOP               
TITLE    2 BOUND WITH U1A AND L7AE PROTEINS                                     
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A;                      
COMPND   3 CHAIN: A, B, E, F;                                                   
COMPND   4 FRAGMENT: RRM 1 DOMAIN, UNP RESIDUES 1-102;                          
COMPND   5 SYNONYM: U1 SNRNP A, U1-A, U1A;                                      
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: HMKT-7;                                                    
COMPND   9 CHAIN: D, H;                                                         
COMPND  10 FRAGMENT: KINK TURN MOTIF;                                           
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: 50S RIBOSOMAL PROTEIN L7AE;                                
COMPND  13 CHAIN: C, G;                                                         
COMPND  14 FRAGMENT: RNA BINDING DOMAIN, UNP RESIDUES 5-119;                    
COMPND  15 SYNONYM: RIBOSOMAL PROTEIN L8E, AFL7AE;                              
COMPND  16 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE   8 EXPRESSION_SYSTEM_VARIANT: GOLD PLYSS;                               
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_VECTOR: PT7;                                       
SOURCE  11 MOL_ID: 2;                                                           
SOURCE  12 SYNTHETIC: YES;                                                      
SOURCE  13 ORGANISM_SCIENTIFIC: HALOARCULA MARISMORTUI;                         
SOURCE  14 ORGANISM_TAXID: 2238;                                                
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: ARCHAEOGLOBUS FULGIDUS;                         
SOURCE  17 ORGANISM_TAXID: 224325;                                              
SOURCE  18 STRAIN: DSM 4304;                                                    
SOURCE  19 ATCC: 49558;                                                         
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  22 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE  23 EXPRESSION_SYSTEM_VARIANT: GOLD PLYSS;                               
SOURCE  24 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  25 EXPRESSION_SYSTEM_VECTOR: PET-DUET1                                  
KEYWDS    TRANSCRIPTION, KINK TURN                                              
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    L.HUANG,D.M.J.LILLEY                                                  
REVDAT   2   06-JUL-16 5FJ4    1       JRNL                                     
REVDAT   1   25-MAY-16 5FJ4    0                                                
JRNL        AUTH   L.HUANG,J.WANG,D.M.J.LILLEY                                  
JRNL        TITL   A CRITICAL BASE PAIR IN K-TURNS DETERMINES THE               
JRNL        TITL 2 CONFORMATIONAL CLASS ADOPTED, AND CORRELATES WITH            
JRNL        TITL 3 BIOLOGICAL FUNCTION.                                         
JRNL        REF    NUCLEIC ACIDS RES.            V.  44  5390 2016              
JRNL        REFN                   ISSN 0305-1048                               
JRNL        PMID   27016741                                                     
JRNL        DOI    10.1093/NAR/GKW201                                           
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.95 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE)                               
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN             
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.950                          
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 80.613                         
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.35                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.91                          
REMARK   3   NUMBER OF REFLECTIONS             : 33933                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.2007                          
REMARK   3   R VALUE            (WORKING SET) : 0.1987                          
REMARK   3   FREE R VALUE                     : 0.2369                          
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.9                             
REMARK   3   FREE R VALUE TEST SET COUNT      : 1654                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE  CCWORK
REMARK   3     1 80.6431 -  6.7527    0.99     2825   143  0.1763 0.2147   0.940
REMARK   3     2  6.7527 -  5.3601    1.00     2726   141  0.1968 0.2296   0.898
REMARK   3     3  5.3601 -  4.6827    1.00     2700   146  0.1715 0.2398   0.917
REMARK   3     4  4.6827 -  4.2546    1.00     2687   153  0.1721 0.2057   0.922
REMARK   3     5  4.2546 -  3.9496    1.00     2668   140  0.1820 0.2290   0.909
REMARK   3     6  3.9496 -  3.7168    1.00     2680   132  0.2001 0.2370   0.899
REMARK   3     7  3.7168 -  3.5306    1.00     2681   155  0.2188 0.2296   0.873
REMARK   3     8  3.5306 -  3.3769    1.00     2635   131  0.2448 0.3198   0.832
REMARK   3     9  3.3769 -  3.2469    1.00     2683   129  0.2740 0.3005   0.790
REMARK   3    10  3.2469 -  3.1349    1.00     2683   130  0.3075 0.3452   0.723
REMARK   3    11  3.1349 -  3.0369    1.00     2655   125  0.3111 0.3369   0.628
REMARK   3    12  3.0369 -  2.9500    1.00     2656   129  0.3289 0.3359   0.524
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.38             
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 26.08            
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 104.08                         
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 128.18                         
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.014           6733                                  
REMARK   3   ANGLE     :  1.845           9406                                  
REMARK   3   CHIRALITY :  0.083           1119                                  
REMARK   3   PLANARITY :  0.013            932                                  
REMARK   3   DIHEDRAL  : 16.468           3982                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 76                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 6:11)                               
REMARK   3    ORIGIN FOR THE GROUP (A): -45.6397  -6.2074 -12.4559              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7628 T22:   0.7319                                     
REMARK   3      T33:   1.2010 T12:  -0.0809                                     
REMARK   3      T13:   0.1818 T23:  -0.1822                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.1838 L22:   1.1191                                     
REMARK   3      L33:   1.3391 L12:  -2.0780                                     
REMARK   3      L13:   2.5909 L23:  -1.1919                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1346 S12:  -2.3760 S13:  -0.2617                       
REMARK   3      S21:  -0.9033 S22:  -0.9977 S23:   2.9113                       
REMARK   3      S31:   0.6909 S32:  -2.5100 S33:   0.8326                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 12:18)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -39.5508 -14.8749 -23.5189              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7525 T22:   1.0947                                     
REMARK   3      T33:   0.5594 T12:  -0.0443                                     
REMARK   3      T13:  -0.0409 T23:   0.0319                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.9144 L22:   3.5416                                     
REMARK   3      L33:   2.8700 L12:  -1.5318                                     
REMARK   3      L13:  -3.2800 L23:   1.2320                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6436 S12:   1.8240 S13:  -0.2996                       
REMARK   3      S21:  -0.8831 S22:  -0.2709 S23:  -0.2912                       
REMARK   3      S31:   1.8755 S32:  -2.5015 S33:   0.1114                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 19:24)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -31.0551 -23.2520 -23.7722              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1277 T22:   0.9991                                     
REMARK   3      T33:   1.0864 T12:   0.1362                                     
REMARK   3      T13:   0.1792 T23:  -0.0666                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7094 L22:   2.3323                                     
REMARK   3      L33:   3.9171 L12:  -0.5619                                     
REMARK   3      L13:   0.5602 L23:  -1.9606                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3824 S12:   0.1863 S13:  -2.5702                       
REMARK   3      S21:  -0.2925 S22:   0.3218 S23:   0.1196                       
REMARK   3      S31:   2.2142 S32:  -0.5016 S33:  -0.2391                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 25:30)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -28.0937 -16.2000 -20.3719              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7692 T22:   1.0360                                     
REMARK   3      T33:   0.7142 T12:  -0.1663                                     
REMARK   3      T13:   0.2552 T23:   0.0452                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.3715 L22:   3.0855                                     
REMARK   3      L33:   7.2958 L12:  -1.7989                                     
REMARK   3      L13:  -1.0874 L23:   4.0808                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.7991 S12:   0.2533 S13:  -0.7448                       
REMARK   3      S21:  -0.6929 S22:   0.6249 S23:  -1.4168                       
REMARK   3      S31:   0.9284 S32:   2.5481 S33:  -0.1775                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 31:36)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -28.8895  -6.6807 -19.1287              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.5672 T22:   0.5746                                     
REMARK   3      T33:   0.2310 T12:  -0.4352                                     
REMARK   3      T13:   1.4457 T23:   0.6004                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.1645 L22:   7.1879                                     
REMARK   3      L33:   3.3569 L12:   2.0993                                     
REMARK   3      L13:   1.0467 L23:   4.9538                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.8254 S12:  -0.8294 S13:  -0.6407                       
REMARK   3      S21:   0.5728 S22:   1.2906 S23:  -0.8608                       
REMARK   3      S31:   1.6406 S32:   2.9054 S33:   0.0588                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 37:42)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -31.4838  -7.1615 -11.5590              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7438 T22:   0.7593                                     
REMARK   3      T33:   0.6149 T12:  -0.1178                                     
REMARK   3      T13:  -0.0434 T23:   0.0753                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.9813 L22:   2.3184                                     
REMARK   3      L33:   2.5097 L12:   0.6753                                     
REMARK   3      L13:  -1.2563 L23:   2.1369                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0968 S12:  -0.3046 S13:   0.0199                       
REMARK   3      S21:  -0.8514 S22:  -2.0123 S23:  -0.6678                       
REMARK   3      S31:   0.0590 S32:   0.5811 S33:   1.2751                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 43:73)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -38.2491 -11.9867 -17.6154              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5040 T22:   0.7756                                     
REMARK   3      T33:   0.6665 T12:  -0.0424                                     
REMARK   3      T13:   0.0932 T23:   0.0073                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.9554 L22:   4.6648                                     
REMARK   3      L33:   4.3156 L12:  -1.2937                                     
REMARK   3      L13:  -0.7740 L23:  -2.5039                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3103 S12:   0.4552 S13:  -0.2549                       
REMARK   3      S21:  -0.2808 S22:   0.2884 S23:   0.2843                       
REMARK   3      S31:   0.0430 S32:  -0.5891 S33:   0.0409                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 74:82)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -34.0970 -11.9046 -29.9895              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9736 T22:   1.0777                                     
REMARK   3      T33:   0.8680 T12:   0.0547                                     
REMARK   3      T13:   0.1157 T23:   0.0343                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.4894 L22:   4.8419                                     
REMARK   3      L33:   4.4482 L12:  -0.3960                                     
REMARK   3      L13:   3.2688 L23:  -1.6791                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5713 S12:   1.6136 S13:  -0.7693                       
REMARK   3      S21:  -0.0248 S22:   0.1725 S23:  -0.5150                       
REMARK   3      S31:  -0.9228 S32:  -0.3917 S33:  -0.2803                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 83:92)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -44.6237 -11.2926 -14.9929              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7696 T22:   0.8857                                     
REMARK   3      T33:   0.8169 T12:  -0.1917                                     
REMARK   3      T13:   0.0292 T23:  -0.0927                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.5238 L22:   3.5043                                     
REMARK   3      L33:   8.2776 L12:  -1.4488                                     
REMARK   3      L13:   0.4652 L23:  -3.7256                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4343 S12:  -0.7969 S13:   0.0672                       
REMARK   3      S21:  -0.8607 S22:   0.6096 S23:   0.5667                       
REMARK   3      S31:   2.2145 S32:  -2.3102 S33:   0.1462                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 93:101)                             
REMARK   3    ORIGIN FOR THE GROUP (A): -41.3882 -11.5223  -0.5409              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5059 T22:   0.7521                                     
REMARK   3      T33:   1.0310 T12:  -0.0122                                     
REMARK   3      T13:   0.1523 T23:   0.0469                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1354 L22:   4.8080                                     
REMARK   3      L33:   6.8954 L12:  -3.4396                                     
REMARK   3      L13:  -0.1791 L23:   2.7797                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2145 S12:  -1.6704 S13:  -0.3403                       
REMARK   3      S21:   0.7688 S22:  -0.1506 S23:   2.3061                       
REMARK   3      S31:   0.5270 S32:  -0.2239 S33:   0.1073                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 7:18)                               
REMARK   3    ORIGIN FOR THE GROUP (A): -14.8473  -3.4567 -34.1588              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1221 T22:   1.1476                                     
REMARK   3      T33:   1.0996 T12:   0.2453                                     
REMARK   3      T13:   0.4702 T23:   0.0616                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.6944 L22:   2.6200                                     
REMARK   3      L33:   3.3182 L12:   1.6957                                     
REMARK   3      L13:   1.0970 L23:  -1.2244                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1496 S12:   0.7906 S13:   0.7303                       
REMARK   3      S21:  -0.6063 S22:  -0.1654 S23:  -0.8041                       
REMARK   3      S31:  -1.2499 S32:   0.5592 S33:  -0.3120                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 19:24)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -14.7690 -12.4199 -18.8630              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9762 T22:   1.4421                                     
REMARK   3      T33:   1.1556 T12:   0.1565                                     
REMARK   3      T13:   0.1237 T23:   0.0634                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0272 L22:   2.0367                                     
REMARK   3      L33:   3.8408 L12:   0.0327                                     
REMARK   3      L13:   0.3473 L23:   1.3405                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0519 S12:   0.1375 S13:  -1.1970                       
REMARK   3      S21:  -0.8013 S22:  -0.0654 S23:  -1.7064                       
REMARK   3      S31:   1.1494 S32:   0.0897 S33:   0.9329                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 25:34)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -21.5475 -13.5410 -27.5484              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8525 T22:   0.6771                                     
REMARK   3      T33:   1.1721 T12:   0.1285                                     
REMARK   3      T13:   0.9259 T23:   0.3400                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.1445 L22:   3.7044                                     
REMARK   3      L33:   4.0498 L12:  -0.0562                                     
REMARK   3      L13:   1.5372 L23:  -1.1900                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.3027 S12:   1.4587 S13:  -1.2205                       
REMARK   3      S21:   0.2864 S22:  -0.4324 S23:  -0.9628                       
REMARK   3      S31:   1.6855 S32:   0.4736 S33:   0.9870                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 35:46)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -20.1688 -12.7375 -34.7894              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2101 T22:   1.1487                                     
REMARK   3      T33:   1.1120 T12:   0.0170                                     
REMARK   3      T13:   0.2935 T23:  -0.1315                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.8564 L22:   6.1708                                     
REMARK   3      L33:   8.4498 L12:   0.7237                                     
REMARK   3      L13:   3.1513 L23:   1.0823                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2836 S12:   0.5176 S13:   0.1065                       
REMARK   3      S21:  -1.1826 S22:  -0.6974 S23:  -0.4339                       
REMARK   3      S31:  -0.2069 S32:  -0.3468 S33:   0.7736                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 47:52)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.2401  -8.2351 -20.8006              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.8743 T22:   1.7027                                     
REMARK   3      T33:   1.5589 T12:   0.0940                                     
REMARK   3      T13:  -0.0030 T23:   0.0960                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.6087 L22:   1.9923                                     
REMARK   3      L33:   7.8404 L12:  -2.2952                                     
REMARK   3      L13:   0.4524 L23:   1.6158                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.8591 S12:   1.3591 S13:   1.2632                       
REMARK   3      S21:   1.4248 S22:  -0.6477 S23:   0.9459                       
REMARK   3      S31:   1.8885 S32:   2.6599 S33:   0.6019                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 53:69)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -19.1568  -6.9608 -38.1820              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3127 T22:   1.1621                                     
REMARK   3      T33:   1.0726 T12:   0.5435                                     
REMARK   3      T13:   0.8652 T23:   0.1480                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.1917 L22:   4.2249                                     
REMARK   3      L33:   4.5271 L12:   2.4958                                     
REMARK   3      L13:  -0.5346 L23:  -0.4570                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3266 S12:   1.9607 S13:   0.3480                       
REMARK   3      S21:  -1.7048 S22:   1.1100 S23:  -0.0733                       
REMARK   3      S31:  -1.5059 S32:   0.8483 S33:   0.6789                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 70:82)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -23.8172  -1.8252 -26.4726              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9809 T22:   0.6793                                     
REMARK   3      T33:   0.9516 T12:  -0.0460                                     
REMARK   3      T13:   0.1581 T23:   0.0164                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.2553 L22:   2.3057                                     
REMARK   3      L33:   8.5916 L12:   0.1067                                     
REMARK   3      L13:  -3.4530 L23:  -2.4524                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1958 S12:  -0.0480 S13:   0.4154                       
REMARK   3      S21:  -0.9069 S22:  -1.2037 S23:   0.0856                       
REMARK   3      S31:  -0.8253 S32:   2.1277 S33:   0.3367                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 83:88)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -14.7541  -0.3334 -35.2965              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2143 T22:   1.0780                                     
REMARK   3      T33:   2.0036 T12:   0.1649                                     
REMARK   3      T13:   0.4303 T23:   0.2699                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.1173 L22:   4.5667                                     
REMARK   3      L33:   3.8742 L12:  -1.3290                                     
REMARK   3      L13:  -2.1386 L23:   3.9562                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.5836 S12:   0.9297 S13:  -0.8027                       
REMARK   3      S21:  -0.4339 S22:   0.9589 S23:  -2.7981                       
REMARK   3      S31:  -1.9297 S32:   0.2601 S33:  -2.1705                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 89:96)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  -6.3031  -9.9931 -37.8050              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2607 T22:   1.5177                                     
REMARK   3      T33:   1.6801 T12:  -0.0376                                     
REMARK   3      T13:   0.8525 T23:  -0.0833                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9826 L22:   5.7786                                     
REMARK   3      L33:   8.2347 L12:   1.0248                                     
REMARK   3      L13:   5.5225 L23:  -4.8452                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6848 S12:  -0.3261 S13:  -0.4251                       
REMARK   3      S21:  -1.3500 S22:   2.0164 S23:  -0.2697                       
REMARK   3      S31:  -1.3332 S32:   2.7395 S33:  -1.0627                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 97:102)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  -3.4050 -13.1487 -30.2792              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.6344 T22:   1.8100                                     
REMARK   3      T33:   1.7441 T12:  -0.2157                                     
REMARK   3      T13:   0.2807 T23:   0.0601                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.1138 L22:   3.7423                                     
REMARK   3      L33:   0.6322 L12:   3.3512                                     
REMARK   3      L13:   0.2345 L23:   1.1206                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3621 S12:   1.5286 S13:  -1.4568                       
REMARK   3      S21:   1.9985 S22:  -0.1593 S23:  -0.4528                       
REMARK   3      S31:   0.0429 S32:   3.0783 S33:   0.3154                       
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 1:12)                               
REMARK   3    ORIGIN FOR THE GROUP (A): -14.9415 -61.1967 -12.0200              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.4658 T22:   1.7533                                     
REMARK   3      T33:   1.7549 T12:  -0.2594                                     
REMARK   3      T13:   0.2525 T23:   0.3097                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.5631 L22:   3.9343                                     
REMARK   3      L33:   5.5933 L12:   0.6561                                     
REMARK   3      L13:   6.0301 L23:   0.4329                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   2.3930 S12:  -2.9647 S13:  -2.2350                       
REMARK   3      S21:   2.5221 S22:   0.9726 S23:   2.5215                       
REMARK   3      S31:  -0.9331 S32:   0.3995 S33:  -2.0896                       
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 13:19)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -19.6810 -50.4901  -6.5152              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.8607 T22:   2.3667                                     
REMARK   3      T33:   1.3219 T12:  -0.4236                                     
REMARK   3      T13:   0.3708 T23:   0.3706                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.0370 L22:   3.7954                                     
REMARK   3      L33:   3.0780 L12:   0.9004                                     
REMARK   3      L13:   2.6013 L23:   2.8439                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   2.2090 S12:  -2.4133 S13:  -0.5850                       
REMARK   3      S21:   1.9347 S22:   0.5774 S23:   0.9400                       
REMARK   3      S31:  -0.5354 S32:  -0.0388 S33:  -2.9999                       
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 20:27)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -18.4606 -39.5487  -7.3957              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.5055 T22:   1.6069                                     
REMARK   3      T33:   1.0596 T12:   0.1853                                     
REMARK   3      T13:   0.3826 T23:  -0.0873                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.6807 L22:   2.6268                                     
REMARK   3      L33:   2.3288 L12:   0.6248                                     
REMARK   3      L13:   2.1932 L23:   2.0910                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6986 S12:  -0.7080 S13:   0.4294                       
REMARK   3      S21:  -0.5789 S22:  -1.8930 S23:  -0.2941                       
REMARK   3      S31:  -0.1405 S32:  -0.7670 S33:   0.1607                       
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 28:56)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -10.4801 -47.5669 -18.8173              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5356 T22:   1.0667                                     
REMARK   3      T33:   0.8819 T12:  -0.1339                                     
REMARK   3      T13:   0.2027 T23:  -0.0375                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.3133 L22:   3.6587                                     
REMARK   3      L33:   4.2632 L12:   0.2480                                     
REMARK   3      L13:   1.6767 L23:  -0.6297                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0739 S12:  -0.9880 S13:  -0.3344                       
REMARK   3      S21:  -0.0631 S22:  -0.3935 S23:   0.3954                       
REMARK   3      S31:   0.3248 S32:  -0.0792 S33:  -0.1465                       
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 57:64)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.6254 -54.9140 -23.6413              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5698 T22:   1.0092                                     
REMARK   3      T33:   1.2105 T12:  -0.0086                                     
REMARK   3      T13:   0.1901 T23:  -0.0098                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4012 L22:   3.5356                                     
REMARK   3      L33:   0.6013 L12:  -0.6144                                     
REMARK   3      L13:  -1.4963 L23:  -0.3355                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.1578 S12:  -0.0464 S13:  -0.8520                       
REMARK   3      S21:   0.0629 S22:  -0.7505 S23:  -0.0376                       
REMARK   3      S31:   1.5050 S32:   1.0876 S33:  -0.5192                       
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 65:69)                              
REMARK   3    ORIGIN FOR THE GROUP (A):   0.2795 -52.8379 -16.3396              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.6792 T22:   1.3330                                     
REMARK   3      T33:   1.3948 T12:  -0.2530                                     
REMARK   3      T13:   0.1854 T23:  -0.1314                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.7518 L22:   3.0207                                     
REMARK   3      L33:   2.4684 L12:   4.3809                                     
REMARK   3      L13:   1.7529 L23:   1.7364                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.2224 S12:   1.6477 S13:  -2.1681                       
REMARK   3      S21:  -0.2370 S22:   1.5696 S23:  -2.1613                       
REMARK   3      S31:   0.8553 S32:   0.9300 S33:   0.3471                       
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 70:77)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -10.1028 -55.2521 -12.9982              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7138 T22:   1.1360                                     
REMARK   3      T33:   1.0213 T12:  -0.0830                                     
REMARK   3      T13:   0.1925 T23:   0.1620                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5892 L22:   2.4052                                     
REMARK   3      L33:   3.2942 L12:   0.2487                                     
REMARK   3      L13:  -0.3328 L23:   2.5423                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4680 S12:  -0.2672 S13:   0.7217                       
REMARK   3      S21:   0.9923 S22:   1.1785 S23:   0.2688                       
REMARK   3      S31:  -0.6969 S32:   1.1555 S33:  -0.7981                       
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 78:98)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -20.6496 -47.2619 -17.2727              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2817 T22:   1.1410                                     
REMARK   3      T33:   0.9172 T12:  -0.1409                                     
REMARK   3      T13:   0.2828 T23:  -0.0197                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.2890 L22:   8.5435                                     
REMARK   3      L33:   3.9758 L12:  -2.1651                                     
REMARK   3      L13:   2.1444 L23:  -1.7152                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2215 S12:  -2.3118 S13:  -1.0063                       
REMARK   3      S21:  -0.1954 S22:   0.9243 S23:   1.4261                       
REMARK   3      S31:  -1.1798 S32:  -0.0802 S33:  -1.0292                       
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 99:111)                             
REMARK   3    ORIGIN FOR THE GROUP (A): -10.8938 -45.0894  -1.1103              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.5480 T22:   2.7239                                     
REMARK   3      T33:   1.4188 T12:   0.3860                                     
REMARK   3      T13:   0.2817 T23:   0.0629                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4030 L22:   2.0292                                     
REMARK   3      L33:   2.5773 L12:   1.2980                                     
REMARK   3      L13:  -0.4452 L23:  -0.0942                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0315 S12:  -2.6463 S13:   1.2784                       
REMARK   3      S21:   3.1815 S22:  -0.1055 S23:   0.4727                       
REMARK   3      S31:   0.6493 S32:   0.5982 S33:  -0.1841                       
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 112:117)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.7842 -58.4667  -3.3768              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7305 T22:   2.0185                                     
REMARK   3      T33:   1.7626 T12:  -0.3199                                     
REMARK   3      T13:  -0.0096 T23:   0.4846                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.5939 L22:   0.2068                                     
REMARK   3      L33:   2.9012 L12:   0.5456                                     
REMARK   3      L13:   0.8457 L23:  -0.3069                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4760 S12:   0.5245 S13:   1.1146                       
REMARK   3      S21:   1.2841 S22:  -0.0067 S23:  -1.6986                       
REMARK   3      S31:  -0.9208 S32:   0.8187 S33:  -0.0639                       
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 1:4)                                
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.8210 -37.0140 -31.3731              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4813 T22:   1.1209                                     
REMARK   3      T33:   0.8214 T12:  -0.0790                                     
REMARK   3      T13:   0.3583 T23:   0.0277                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.3859 L22:   2.5201                                     
REMARK   3      L33:   4.8650 L12:  -2.0191                                     
REMARK   3      L13:  -3.6777 L23:  -0.7131                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.9319 S12:   0.4379 S13:  -0.0220                       
REMARK   3      S21:  -0.7591 S22:   0.5085 S23:   0.4699                       
REMARK   3      S31:   1.5291 S32:  -0.7337 S33:  -1.1934                       
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 5:9)                                
REMARK   3    ORIGIN FOR THE GROUP (A): -23.1627 -34.4899 -27.0824              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5367 T22:   0.9482                                     
REMARK   3      T33:   1.0884 T12:  -0.0607                                     
REMARK   3      T13:   0.1465 T23:  -0.2030                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8171 L22:   3.2806                                     
REMARK   3      L33:   3.1483 L12:   1.0145                                     
REMARK   3      L13:   1.1035 L23:  -1.5793                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0436 S12:   0.3531 S13:  -0.6693                       
REMARK   3      S21:  -0.3407 S22:   0.3548 S23:   0.8526                       
REMARK   3      S31:  -0.6491 S32:  -0.2260 S33:  -0.6675                       
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 10:13)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -41.3436 -30.8661 -32.9088              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2369 T22:   1.5197                                     
REMARK   3      T33:   1.4689 T12:  -0.1536                                     
REMARK   3      T13:  -0.0376 T23:  -0.4680                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2574 L22:   4.6390                                     
REMARK   3      L33:   8.0914 L12:   0.2868                                     
REMARK   3      L13:  -2.6026 L23:   2.5683                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.1197 S12:   3.4602 S13:  -2.3366                       
REMARK   3      S21:  -0.5004 S22:  -2.2876 S23:   0.8246                       
REMARK   3      S31:  -0.1471 S32:  -1.0841 S33:   2.7951                       
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 14:17)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -46.1433 -19.7205 -20.6321              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9520 T22:   1.0508                                     
REMARK   3      T33:   1.1278 T12:  -0.0761                                     
REMARK   3      T13:  -0.1814 T23:  -0.0844                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.6306 L22:   4.0331                                     
REMARK   3      L33:   3.1700 L12:  -0.5442                                     
REMARK   3      L13:   0.0122 L23:  -0.0725                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.5270 S12:   0.7837 S13:  -1.5526                       
REMARK   3      S21:  -1.5258 S22:   0.0391 S23:   0.8535                       
REMARK   3      S31:   0.5276 S32:   0.4040 S33:  -0.2060                       
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 18:21)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -40.3211 -27.9543  -9.6594              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3310 T22:   1.1533                                     
REMARK   3      T33:   1.4420 T12:   0.0733                                     
REMARK   3      T13:   0.0082 T23:  -0.1320                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.3968 L22:   3.5540                                     
REMARK   3      L33:   1.1942 L12:  -3.6317                                     
REMARK   3      L13:  -1.1421 L23:   1.6957                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6878 S12:   0.7917 S13:  -2.4725                       
REMARK   3      S21:   2.9061 S22:   1.4151 S23:   3.2090                       
REMARK   3      S31:   2.4008 S32:  -0.3522 S33:   0.0863                       
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 22:27)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -34.5696 -39.7820 -28.1725              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3541 T22:   0.9233                                     
REMARK   3      T33:   1.4557 T12:  -0.1337                                     
REMARK   3      T13:   0.1828 T23:  -0.4167                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.5839 L22:   0.2821                                     
REMARK   3      L33:   1.2962 L12:   0.6513                                     
REMARK   3      L13:   1.5564 L23:   0.7546                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.2269 S12:   0.5806 S13:  -0.9929                       
REMARK   3      S21:   0.7626 S22:  -0.7795 S23:   1.0533                       
REMARK   3      S31:   0.0548 S32:   0.4817 S33:  -0.5220                       
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 28:31)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -18.3304 -42.9510 -27.3234              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.6181 T22:   0.7986                                     
REMARK   3      T33:   0.8603 T12:   0.0622                                     
REMARK   3      T13:   0.1683 T23:  -0.0544                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.5791 L22:   7.4576                                     
REMARK   3      L33:   6.4781 L12:  -2.8109                                     
REMARK   3      L13:   0.5158 L23:  -2.9578                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.0725 S12:  -0.5946 S13:  -0.2990                       
REMARK   3      S21:   0.0703 S22:  -0.9534 S23:   1.3793                       
REMARK   3      S31:   0.3510 S32:   0.3356 S33:  -0.1699                       
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 32:35)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -13.4280 -29.3495 -32.9911              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4058 T22:   1.0635                                     
REMARK   3      T33:   1.1071 T12:  -0.0116                                     
REMARK   3      T13:   0.3373 T23:  -0.0356                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4151 L22:   1.4822                                     
REMARK   3      L33:   2.0278 L12:   1.1421                                     
REMARK   3      L13:  -2.4820 L23:  -0.8464                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6562 S12:  -0.1114 S13:   0.3560                       
REMARK   3      S21:  -0.2098 S22:  -0.0953 S23:   1.1871                       
REMARK   3      S31:   0.9320 S32:  -0.5490 S33:  -0.1505                       
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 6:10)                               
REMARK   3    ORIGIN FOR THE GROUP (A):  43.4866 -71.3502 -10.0727              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4759 T22:   0.8265                                     
REMARK   3      T33:   1.5740 T12:  -0.1179                                     
REMARK   3      T13:  -0.0468 T23:   0.2906                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.8908 L22:   4.1673                                     
REMARK   3      L33:   6.4039 L12:  -2.8677                                     
REMARK   3      L13:   3.1713 L23:  -1.1467                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.9496 S12:  -1.2667 S13:   0.0897                       
REMARK   3      S21:   0.0465 S22:   0.0378 S23:  -3.4443                       
REMARK   3      S31:  -2.4435 S32:   1.3805 S33:   0.7866                       
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 11:21)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  35.2946 -57.2348 -18.0990              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9139 T22:   0.7124                                     
REMARK   3      T33:   0.9151 T12:   0.1467                                     
REMARK   3      T13:  -0.0415 T23:   0.1544                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4737 L22:   4.8049                                     
REMARK   3      L33:   3.7897 L12:  -0.2437                                     
REMARK   3      L13:   1.5525 L23:   0.8099                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5336 S12:   1.9527 S13:   0.6602                       
REMARK   3      S21:  -1.2555 S22:  -0.5793 S23:  -1.3272                       
REMARK   3      S31:  -1.5716 S32:  -0.2025 S33:   0.6236                       
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 22:26)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  25.1997 -53.6785 -14.0552              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1005 T22:   1.0155                                     
REMARK   3      T33:   1.1331 T12:   0.2622                                     
REMARK   3      T13:   0.1643 T23:   0.0378                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.8842 L22:   5.2469                                     
REMARK   3      L33:   6.2626 L12:  -2.7002                                     
REMARK   3      L13:   0.1395 L23:  -4.1595                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.7100 S12:  -1.3519 S13:   3.5154                       
REMARK   3      S21:   0.0549 S22:   1.3151 S23:   1.0507                       
REMARK   3      S31:  -0.7335 S32:  -1.1801 S33:  -1.2190                       
REMARK   3   TLS GROUP : 42                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 27:34)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  25.7700 -63.4734 -15.3612              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6808 T22:   0.8558                                     
REMARK   3      T33:   0.5569 T12:   0.2817                                     
REMARK   3      T13:   0.0378 T23:   0.0769                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.9650 L22:   5.2652                                     
REMARK   3      L33:   4.0066 L12:  -1.5568                                     
REMARK   3      L13:  -1.0642 L23:   2.1408                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3619 S12:  -0.3437 S13:   1.1127                       
REMARK   3      S21:   0.9752 S22:  -0.3937 S23:  -0.6380                       
REMARK   3      S31:   0.0586 S32:  -0.7186 S33:  -0.7213                       
REMARK   3   TLS GROUP : 43                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 35:39)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  27.2390 -72.9456 -14.1804              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7279 T22:   0.6418                                     
REMARK   3      T33:   0.8494 T12:  -0.0858                                     
REMARK   3      T13:   0.1451 T23:   0.3094                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2720 L22:   2.6419                                     
REMARK   3      L33:   2.6813 L12:  -1.7403                                     
REMARK   3      L13:  -2.4137 L23:   2.2634                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4699 S12:  -1.7322 S13:   0.8790                       
REMARK   3      S21:  -0.5036 S22:  -0.6353 S23:   1.5365                       
REMARK   3      S31:  -0.4097 S32:   0.4999 S33:   0.5123                       
REMARK   3   TLS GROUP : 44                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 40:59)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  34.4162 -57.8185 -10.7368              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6054 T22:   0.5541                                     
REMARK   3      T33:   0.9008 T12:  -0.0332                                     
REMARK   3      T13:  -0.1321 T23:   0.1408                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.2386 L22:   5.0415                                     
REMARK   3      L33:   5.1581 L12:   2.7912                                     
REMARK   3      L13:  -1.2297 L23:  -0.5996                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0681 S12:   0.3315 S13:   1.2989                       
REMARK   3      S21:  -0.0106 S22:   0.1012 S23:   1.1082                       
REMARK   3      S31:  -0.4209 S32:   0.4207 S33:  -0.0741                       
REMARK   3   TLS GROUP : 45                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 60:65)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  34.0840 -75.3542  -9.2509              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5420 T22:   0.7519                                     
REMARK   3      T33:   1.1757 T12:   0.1633                                     
REMARK   3      T13:  -0.2019 T23:  -0.1145                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0111 L22:   7.2030                                     
REMARK   3      L33:   4.4880 L12:  -4.3482                                     
REMARK   3      L13:  -4.9169 L23:   4.1571                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5823 S12:   0.3287 S13:  -0.1847                       
REMARK   3      S21:   1.3228 S22:  -0.0935 S23:   0.7673                       
REMARK   3      S31:   1.8121 S32:  -1.0534 S33:   0.6165                       
REMARK   3   TLS GROUP : 46                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 66:82)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  33.6652 -65.6888 -22.9872              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9066 T22:   0.8204                                     
REMARK   3      T33:   0.6937 T12:   0.1406                                     
REMARK   3      T13:   0.1381 T23:   0.0772                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.1414 L22:   9.1670                                     
REMARK   3      L33:   6.3466 L12:   0.9489                                     
REMARK   3      L13:   1.1685 L23:  -0.9265                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0073 S12:   0.9523 S13:   0.5547                       
REMARK   3      S21:  -3.0005 S22:  -0.4528 S23:  -1.0757                       
REMARK   3      S31:   0.1204 S32:  -0.4014 S33:   0.1182                       
REMARK   3   TLS GROUP : 47                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 83:96)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  40.4361 -65.8542  -7.6883              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6664 T22:   0.8075                                     
REMARK   3      T33:   0.9089 T12:   0.0518                                     
REMARK   3      T13:   0.0888 T23:   0.1610                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1719 L22:   0.8584                                     
REMARK   3      L33:   5.0963 L12:  -1.0157                                     
REMARK   3      L13:  -0.0535 L23:   0.0934                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0605 S12:   0.1680 S13:   0.0090                       
REMARK   3      S21:  -0.5384 S22:  -0.2457 S23:  -0.8781                       
REMARK   3      S31:  -0.8372 S32:   1.2676 S33:   0.3149                       
REMARK   3   TLS GROUP : 48                                                     
REMARK   3    SELECTION: (CHAIN E AND RESID 97:102)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  40.2240 -69.2656   4.2894              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7700 T22:   0.9030                                     
REMARK   3      T33:   1.0627 T12:   0.1162                                     
REMARK   3      T13:  -0.1580 T23:   0.1876                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.1179 L22:   3.3753                                     
REMARK   3      L33:   5.6313 L12:   1.7300                                     
REMARK   3      L13:  -4.9268 L23:  -3.2256                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.5001 S12:  -1.5990 S13:  -1.2323                       
REMARK   3      S21:   0.5027 S22:   2.0235 S23:  -1.0948                       
REMARK   3      S31:   0.2089 S32:  -0.5596 S33:  -1.0963                       
REMARK   3   TLS GROUP : 49                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 7:18)                               
REMARK   3    ORIGIN FOR THE GROUP (A):  12.9199 -67.4580 -32.5568              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9001 T22:   1.5627                                     
REMARK   3      T33:   0.7823 T12:   0.1997                                     
REMARK   3      T13:   0.0167 T23:   0.0104                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.3298 L22:   4.8703                                     
REMARK   3      L33:   4.0963 L12:   1.6149                                     
REMARK   3      L13:  -1.4373 L23:   0.3709                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3730 S12:   1.1111 S13:  -0.0542                       
REMARK   3      S21:  -0.2160 S22:  -0.2202 S23:   1.2078                       
REMARK   3      S31:  -0.9385 S32:  -1.6409 S33:  -0.3215                       
REMARK   3   TLS GROUP : 50                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 19:24)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  11.8905 -63.6698 -15.7700              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9165 T22:   1.9642                                     
REMARK   3      T33:   0.8944 T12:   0.2324                                     
REMARK   3      T13:  -0.0513 T23:   0.0183                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8654 L22:   9.9091                                     
REMARK   3      L33:   3.1771 L12:  -0.1291                                     
REMARK   3      L13:  -0.7690 L23:  -2.2240                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2190 S12:  -0.7088 S13:   0.3189                       
REMARK   3      S21:   1.6040 S22:  -1.0320 S23:   1.0970                       
REMARK   3      S31:   0.1483 S32:  -1.0823 S33:   0.7183                       
REMARK   3   TLS GROUP : 51                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 25:46)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  18.4036 -59.1042 -26.7236              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9624 T22:   1.1682                                     
REMARK   3      T33:   0.8275 T12:   0.2861                                     
REMARK   3      T13:  -0.1462 T23:   0.0507                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.5045 L22:   5.4512                                     
REMARK   3      L33:   7.7061 L12:  -0.3543                                     
REMARK   3      L13:  -0.3674 L23:  -0.2289                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4538 S12:   0.9221 S13:   1.7572                       
REMARK   3      S21:  -0.9387 S22:  -0.2031 S23:  -0.4669                       
REMARK   3      S31:  -0.9009 S32:  -1.0513 S33:   0.5625                       
REMARK   3   TLS GROUP : 52                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 47:52)                              
REMARK   3    ORIGIN FOR THE GROUP (A):   3.7132 -67.0778 -18.9447              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.9930 T22:   2.4073                                     
REMARK   3      T33:   1.1061 T12:   0.0539                                     
REMARK   3      T13:  -0.2977 T23:  -0.0098                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.7868 L22:   2.2443                                     
REMARK   3      L33:   4.6675 L12:  -0.3514                                     
REMARK   3      L13:  -0.4738 L23:   3.2415                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.7258 S12:   1.2078 S13:   0.6776                       
REMARK   3      S21:   2.3195 S22:   0.5222 S23:   0.2744                       
REMARK   3      S31:  -1.2856 S32:  -0.1922 S33:  -1.2962                       
REMARK   3   TLS GROUP : 53                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 53:66)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  15.9708 -62.1252 -35.0936              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2594 T22:   1.4065                                     
REMARK   3      T33:   0.5860 T12:   0.4156                                     
REMARK   3      T13:  -0.0972 T23:   0.3731                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6597 L22:   3.8593                                     
REMARK   3      L33:   3.9037 L12:   1.1310                                     
REMARK   3      L13:   0.2593 L23:   1.9844                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1561 S12:  -0.1056 S13:   0.4427                       
REMARK   3      S21:  -2.5030 S22:   0.0993 S23:   0.8078                       
REMARK   3      S31:  -0.4888 S32:  -0.8725 S33:  -0.2662                       
REMARK   3   TLS GROUP : 54                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 67:72)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  23.3689 -69.2556 -34.7248              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5023 T22:   0.9515                                     
REMARK   3      T33:   0.9192 T12:   0.2853                                     
REMARK   3      T13:   0.3424 T23:   0.2128                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5246 L22:   2.1064                                     
REMARK   3      L33:   1.0161 L12:  -1.7804                                     
REMARK   3      L13:   0.8960 L23:  -0.9640                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.8880 S12:   1.0120 S13:   0.3877                       
REMARK   3      S21:  -1.8166 S22:  -0.4308 S23:  -1.5525                       
REMARK   3      S31:   0.2475 S32:   0.6493 S33:   0.8889                       
REMARK   3   TLS GROUP : 55                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 73:82)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  20.4686 -71.5881 -22.5946              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7520 T22:   0.8298                                     
REMARK   3      T33:   0.8643 T12:   0.1091                                     
REMARK   3      T13:  -0.0266 T23:   0.0545                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.3096 L22:   6.9550                                     
REMARK   3      L33:   3.7730 L12:  -1.1664                                     
REMARK   3      L13:   1.3669 L23:   0.7014                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2493 S12:   0.0765 S13:  -0.1382                       
REMARK   3      S21:  -0.5738 S22:  -1.2936 S23:  -0.5451                       
REMARK   3      S31:   1.0276 S32:  -0.9274 S33:   0.6690                       
REMARK   3   TLS GROUP : 56                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 83:87)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  14.0153 -70.7667 -34.0304              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3516 T22:   1.2319                                     
REMARK   3      T33:   0.5658 T12:   0.3118                                     
REMARK   3      T13:  -0.0649 T23:   0.0118                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.3819 L22:   2.2708                                     
REMARK   3      L33:   1.6387 L12:  -1.3083                                     
REMARK   3      L13:   0.4239 L23:  -1.6193                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2103 S12:   0.6997 S13:   0.5722                       
REMARK   3      S21:  -0.4705 S22:   1.0418 S23:   2.5919                       
REMARK   3      S31:  -1.2028 S32:  -1.4740 S33:   0.2976                       
REMARK   3   TLS GROUP : 57                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 88:93)                              
REMARK   3    ORIGIN FOR THE GROUP (A):   5.2692 -62.1388 -36.7638              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5511 T22:   2.5088                                     
REMARK   3      T33:   0.5413 T12:   1.1290                                     
REMARK   3      T13:  -2.1586 T23:  -0.6074                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0787 L22:   1.3933                                     
REMARK   3      L33:   1.2758 L12:   0.6666                                     
REMARK   3      L13:   1.0917 L23:   0.2466                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6211 S12:   1.9727 S13:   0.5507                       
REMARK   3      S21:  -0.3179 S22:  -0.6097 S23:  -0.1352                       
REMARK   3      S31:  -1.3534 S32:  -0.4265 S33:  -0.3006                       
REMARK   3   TLS GROUP : 58                                                     
REMARK   3    SELECTION: (CHAIN F AND RESID 94:102)                             
REMARK   3    ORIGIN FOR THE GROUP (A):   1.7088 -59.3241 -28.7415              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3619 T22:   1.5950                                     
REMARK   3      T33:   1.0178 T12:   0.7184                                     
REMARK   3      T13:  -0.1370 T23:  -0.1388                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2697 L22:   5.3298                                     
REMARK   3      L33:   5.1961 L12:  -0.5191                                     
REMARK   3      L13:   0.8712 L23:   1.5353                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0724 S12:   1.6354 S13:   2.2113                       
REMARK   3      S21:  -2.6199 S22:  -2.0256 S23:   1.6426                       
REMARK   3      S31:   0.4220 S32:  -0.7101 S33:   1.3720                       
REMARK   3   TLS GROUP : 59                                                     
REMARK   3    SELECTION: (CHAIN G AND RESID 1:10)                               
REMARK   3    ORIGIN FOR THE GROUP (A):   4.9093 -12.4597  -5.8580              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.4594 T22:   1.0578                                     
REMARK   3      T33:   1.9690 T12:   0.2758                                     
REMARK   3      T13:  -0.4391 T23:  -0.3729                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.5985 L22:   6.7039                                     
REMARK   3      L33:   2.3318 L12:  -0.5564                                     
REMARK   3      L13:   0.7939 L23:   2.4152                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.1349 S12:  -0.9115 S13:   3.0936                       
REMARK   3      S21:   0.3826 S22:  -0.8192 S23:  -1.1767                       
REMARK   3      S31:   1.3048 S32:  -0.6938 S33:   0.3123                       
REMARK   3   TLS GROUP : 60                                                     
REMARK   3    SELECTION: (CHAIN G AND RESID 11:28)                              
REMARK   3    ORIGIN FOR THE GROUP (A):   6.7828 -30.0916  -1.3504              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.3710 T22:   2.0002                                     
REMARK   3      T33:   0.9930 T12:  -0.3879                                     
REMARK   3      T13:  -0.1314 T23:  -0.5174                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.6412 L22:   5.0810                                     
REMARK   3      L33:   6.1348 L12:  -0.4932                                     
REMARK   3      L13:  -0.9468 L23:  -2.4172                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6687 S12:  -2.6735 S13:   0.7503                       
REMARK   3      S21:   0.0567 S22:  -0.3153 S23:   0.4902                       
REMARK   3      S31:  -0.7791 S32:   2.7139 S33:   0.4497                       
REMARK   3   TLS GROUP : 61                                                     
REMARK   3    SELECTION: (CHAIN G AND RESID 29:39)                              
REMARK   3    ORIGIN FOR THE GROUP (A):   3.4585 -29.6764 -17.0405              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0048 T22:   1.2367                                     
REMARK   3      T33:   0.9413 T12:  -0.0314                                     
REMARK   3      T13:  -0.0106 T23:  -0.0405                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0811 L22:   1.7458                                     
REMARK   3      L33:   1.9174 L12:  -1.4294                                     
REMARK   3      L13:   0.0886 L23:  -0.1511                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4245 S12:   1.8632 S13:  -0.1839                       
REMARK   3      S21:  -0.7511 S22:  -0.0146 S23:  -0.5228                       
REMARK   3      S31:  -0.0464 S32:  -1.9581 S33:   1.0168                       
REMARK   3   TLS GROUP : 62                                                     
REMARK   3    SELECTION: (CHAIN G AND RESID 40:46)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.2414 -29.9493 -13.8587              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3975 T22:   1.6562                                     
REMARK   3      T33:   1.1307 T12:  -0.0753                                     
REMARK   3      T13:   0.3282 T23:  -0.0672                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6367 L22:   1.8343                                     
REMARK   3      L33:   5.5340 L12:   0.7286                                     
REMARK   3      L13:   3.0693 L23:   2.6150                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -2.3976 S12:  -1.1152 S13:  -1.3556                       
REMARK   3      S21:  -1.1195 S22:  -1.0642 S23:  -0.9124                       
REMARK   3      S31:  -0.2673 S32:  -0.2816 S33:   2.9256                       
REMARK   3   TLS GROUP : 63                                                     
REMARK   3    SELECTION: (CHAIN G AND RESID 47:79)                              
REMARK   3    ORIGIN FOR THE GROUP (A):   3.5220 -18.9246 -13.5237              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5318 T22:   1.0885                                     
REMARK   3      T33:   1.1719 T12:   0.0014                                     
REMARK   3      T13:   0.1766 T23:  -0.3364                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.1275 L22:   3.0932                                     
REMARK   3      L33:   3.1246 L12:   0.2147                                     
REMARK   3      L13:  -2.4485 L23:  -2.5815                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1808 S12:  -0.0941 S13:   0.5094                       
REMARK   3      S21:   1.0346 S22:  -0.3071 S23:   0.4640                       
REMARK   3      S31:  -1.2868 S32:  -0.1815 S33:   0.0527                       
REMARK   3   TLS GROUP : 64                                                     
REMARK   3    SELECTION: (CHAIN G AND RESID 80:85)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  15.5948 -25.5046  -6.7738              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7017 T22:   1.8504                                     
REMARK   3      T33:   1.4954 T12:   0.1635                                     
REMARK   3      T13:  -0.5623 T23:  -0.4553                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.7132 L22:   4.0437                                     
REMARK   3      L33:   1.8706 L12:   5.4285                                     
REMARK   3      L13:   0.3836 L23:  -0.3663                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.1653 S12:  -2.4104 S13:  -0.3106                       
REMARK   3      S21:  -0.3059 S22:  -0.9227 S23:  -1.9507                       
REMARK   3      S31:   1.1231 S32:   0.3384 S33:  -0.2382                       
REMARK   3   TLS GROUP : 65                                                     
REMARK   3    SELECTION: (CHAIN G AND RESID 86:97)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  11.9343 -28.7717 -11.0945              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.6717 T22:   1.0730                                     
REMARK   3      T33:   1.0567 T12:   0.0589                                     
REMARK   3      T13:   0.0560 T23:  -0.1198                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.0797 L22:   3.7421                                     
REMARK   3      L33:   4.3271 L12:  -5.0789                                     
REMARK   3      L13:   1.6348 L23:  -2.3674                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6732 S12:  -1.2453 S13:   0.9122                       
REMARK   3      S21:  -0.2898 S22:   0.2372 S23:  -2.0348                       
REMARK   3      S31:   0.5368 S32:  -1.9160 S33:  -0.3149                       
REMARK   3   TLS GROUP : 66                                                     
REMARK   3    SELECTION: (CHAIN G AND RESID 98:103)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.9760 -35.7209  -1.8741              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7706 T22:   2.1565                                     
REMARK   3      T33:   0.8923 T12:   0.1273                                     
REMARK   3      T13:  -0.0930 T23:  -0.1431                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3019 L22:   1.2043                                     
REMARK   3      L33:   3.4681 L12:   0.4356                                     
REMARK   3      L13:  -1.0226 L23:  -1.5940                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1697 S12:  -1.2300 S13:  -1.0790                       
REMARK   3      S21:   0.1934 S22:   1.6560 S23:  -1.3419                       
REMARK   3      S31:  -0.2094 S32:   1.1198 S33:  -1.2163                       
REMARK   3   TLS GROUP : 67                                                     
REMARK   3    SELECTION: (CHAIN G AND RESID 104:111)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -3.2613 -27.9833   2.7297              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.0554 T22:   4.1921                                     
REMARK   3      T33:   0.6652 T12:   0.1838                                     
REMARK   3      T13:   1.0061 T23:  -1.8336                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.0833 L22:   0.8899                                     
REMARK   3      L33:   0.4842 L12:   0.2539                                     
REMARK   3      L13:   0.7893 L23:   0.6061                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1893 S12:  -3.0363 S13:  -1.8594                       
REMARK   3      S21:  -0.5876 S22:   0.1889 S23:   0.5587                       
REMARK   3      S31:  -0.9120 S32:   1.0669 S33:   0.2104                       
REMARK   3   TLS GROUP : 68                                                     
REMARK   3    SELECTION: (CHAIN G AND RESID 112:117)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.3459 -17.0671   0.5600              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.6308 T22:   2.4954                                     
REMARK   3      T33:   1.5681 T12:  -0.0946                                     
REMARK   3      T13:  -0.0013 T23:  -1.1692                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.1754 L22:   2.0985                                     
REMARK   3      L33:   7.7909 L12:   0.1138                                     
REMARK   3      L13:   5.5486 L23:  -0.3364                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.1933 S12:  -0.7110 S13:  -1.1204                       
REMARK   3      S21:   1.0467 S22:  -0.3978 S23:  -0.1624                       
REMARK   3      S31:   2.5349 S32:  -0.1806 S33:   1.1455                       
REMARK   3   TLS GROUP : 69                                                     
REMARK   3    SELECTION: (CHAIN H AND RESID 1:4)                                
REMARK   3    ORIGIN FOR THE GROUP (A):   5.4842 -34.4869 -29.2272              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4902 T22:   1.0072                                     
REMARK   3      T33:   0.8257 T12:   0.1923                                     
REMARK   3      T13:   0.3089 T23:  -0.0881                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.8714 L22:   8.3718                                     
REMARK   3      L33:   2.5960 L12:  -2.5576                                     
REMARK   3      L13:   0.2060 L23:  -3.2836                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.0587 S12:   1.1807 S13:   1.8661                       
REMARK   3      S21:  -3.3772 S22:   0.7552 S23:  -2.6384                       
REMARK   3      S31:   0.6631 S32:   0.5726 S33:  -1.3389                       
REMARK   3   TLS GROUP : 70                                                     
REMARK   3    SELECTION: (CHAIN H AND RESID 5:9)                                
REMARK   3    ORIGIN FOR THE GROUP (A):  18.3535 -38.3994 -19.9739              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2483 T22:   0.7636                                     
REMARK   3      T33:   1.6622 T12:   0.0930                                     
REMARK   3      T13:  -0.0020 T23:   0.0394                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.1897 L22:   2.9550                                     
REMARK   3      L33:   3.2108 L12:  -0.7672                                     
REMARK   3      L13:  -0.3682 L23:   0.5188                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.8963 S12:  -0.2303 S13:   1.8440                       
REMARK   3      S21:   0.0349 S22:  -0.0667 S23:  -2.1564                       
REMARK   3      S31:   0.4525 S32:   0.3041 S33:   0.7934                       
REMARK   3   TLS GROUP : 71                                                     
REMARK   3    SELECTION: (CHAIN H AND RESID 10:13)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  38.4674 -41.1478 -22.5405              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2128 T22:   1.1329                                     
REMARK   3      T33:   1.6562 T12:  -0.0220                                     
REMARK   3      T13:   0.3678 T23:   0.3443                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2664 L22:   1.0617                                     
REMARK   3      L33:  -0.0478 L12:  -0.5806                                     
REMARK   3      L13:  -0.0213 L23:   0.0881                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1514 S12:   1.0689 S13:  -0.1286                       
REMARK   3      S21:  -1.5000 S22:   0.2379 S23:  -0.7835                       
REMARK   3      S31:   0.3224 S32:  -0.6180 S33:   0.1170                       
REMARK   3   TLS GROUP : 72                                                     
REMARK   3    SELECTION: (CHAIN H AND RESID 14:18)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  42.3422 -55.8675 -11.4695              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6838 T22:   0.8332                                     
REMARK   3      T33:   1.2398 T12:   0.0430                                     
REMARK   3      T13:   0.1468 T23:   0.0593                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.6237 L22:   6.8230                                     
REMARK   3      L33:   4.2481 L12:   0.4567                                     
REMARK   3      L13:  -0.2008 L23:   0.8467                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2889 S12:   1.1814 S13:   1.4478                       
REMARK   3      S21:  -0.2271 S22:   0.7350 S23:  -0.9376                       
REMARK   3      S31:  -0.8652 S32:  -1.1870 S33:  -1.4736                       
REMARK   3   TLS GROUP : 73                                                     
REMARK   3    SELECTION: (CHAIN H AND RESID 19:22)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  36.7491 -46.5864  -4.1731              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5840 T22:   1.4671                                     
REMARK   3      T33:   1.6743 T12:  -0.2387                                     
REMARK   3      T13:  -0.0495 T23:   0.1092                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.5071 L22:   5.8489                                     
REMARK   3      L33:   5.4715 L12:  -2.4922                                     
REMARK   3      L13:   1.7794 L23:   2.2762                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3483 S12:  -4.8204 S13:   2.0829                       
REMARK   3      S21:   0.9614 S22:   1.4612 S23:   0.7672                       
REMARK   3      S31:   2.4601 S32:  -1.1497 S33:  -1.3431                       
REMARK   3   TLS GROUP : 74                                                     
REMARK   3    SELECTION: (CHAIN H AND RESID 23:26)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  31.6247 -32.9660 -17.5838              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5268 T22:   0.9969                                     
REMARK   3      T33:   2.6799 T12:   0.0291                                     
REMARK   3      T13:  -0.4061 T23:   0.3285                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.9508 L22:   4.1325                                     
REMARK   3      L33:   1.2373 L12:  -2.1305                                     
REMARK   3      L13:   2.0656 L23:  -0.0236                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5749 S12:   2.4773 S13:   1.9789                       
REMARK   3      S21:   1.2985 S22:  -0.2793 S23:   1.1206                       
REMARK   3      S31:  -0.5725 S32:   1.3435 S33:   0.5471                       
REMARK   3   TLS GROUP : 75                                                     
REMARK   3    SELECTION: (CHAIN H AND RESID 27:31)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  15.5483 -29.7825 -20.2318              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4896 T22:   0.9332                                     
REMARK   3      T33:   1.3859 T12:   0.2027                                     
REMARK   3      T13:   0.0200 T23:   0.1151                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.6496 L22:   3.5224                                     
REMARK   3      L33:   3.1464 L12:  -0.2519                                     
REMARK   3      L13:  -0.1540 L23:  -0.0703                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1749 S12:  -0.1357 S13:   0.5418                       
REMARK   3      S21:  -0.3674 S22:  -1.0984 S23:  -2.6592                       
REMARK   3      S31:  -0.7167 S32:   0.0795 S33:   0.6762                       
REMARK   3   TLS GROUP : 76                                                     
REMARK   3    SELECTION: (CHAIN H AND RESID 32:35)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  11.1139 -42.4005 -29.1405              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7075 T22:   1.0898                                     
REMARK   3      T33:   1.1213 T12:   0.1079                                     
REMARK   3      T13:   0.1294 T23:  -0.0194                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.0078 L22:   7.0942                                     
REMARK   3      L33:   6.2928 L12:   0.1624                                     
REMARK   3      L13:   0.5988 L23:  -0.6054                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.7948 S12:  -0.2902 S13:   0.3999                       
REMARK   3      S21:  -0.4655 S22:  -0.3662 S23:  -0.0909                       
REMARK   3      S31:  -0.3310 S32:   0.0203 S33:   1.0990                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : 2                                           
REMARK   3   NCS GROUP : 1                                                      
REMARK   3     SELECTION          : (CHAIN A AND (RESSEQ 6:27 OR                
REMARK   3                        : RESSEQ 29:82 OR RESSEQ 84:102))             
REMARK   3     SELECTION          : (CHAIN E AND (RESSEQ 6:27 OR                
REMARK   3                        : RESSEQ 29:82 OR RESSEQ 84:102))             
REMARK   3     RESTRAINED TORSIONS: 866                                         
REMARK   3     BELOW LIMIT RMSD   : 2.631                                       
REMARK   3     ALL RESTRAINT RMSD : 13.168                                      
REMARK   3   NCS GROUP : 2                                                      
REMARK   3     SELECTION          : (CHAIN C AND (RESSEQ 0:8 OR RESSEQ          
REMARK   3                        : 10:11 OR RESSEQ 13:20 OR RESSEQ             
REMARK   3                        : 22:60 OR RESSEQ 62:66 OR RESSEQ             
REMARK   3                        : 68:76 OR RESSEQ 78:83 OR RESSEQ             
REMARK   3                        : 85:104 OR RESSEQ 106:112 OR RESSEQ          
REMARK   3                        : 114:117))                                   
REMARK   3     SELECTION          : (CHAIN G AND (RESSEQ 0:8 OR RESSEQ          
REMARK   3                        : 10:11 OR RESSEQ 13:20 OR RESSEQ             
REMARK   3                        : 22:60 OR RESSEQ 62:66 OR RESSEQ             
REMARK   3                        : 68:76 OR RESSEQ 78:83 OR RESSEQ             
REMARK   3                        : 85:104 OR RESSEQ 106:112 OR RESSEQ          
REMARK   3                        : 114:117))                                   
REMARK   3     RESTRAINED TORSIONS: 852                                         
REMARK   3     BELOW LIMIT RMSD   : 2.631                                       
REMARK   3     ALL RESTRAINT RMSD : 13.168                                      
REMARK   3    HISTOGRAM OF DIFFERENCES UNDER LIMIT:                             
REMARK   3       0.000 -    1.500: 1058                                         
REMARK   3       1.500 -    3.000: 336                                          
REMARK   3       3.000 -    4.500: 128                                          
REMARK   3       4.500 -    6.000: 62                                           
REMARK   3       6.000 -    7.500: 18                                           
REMARK   3       7.500 -    9.000: 20                                           
REMARK   3       9.000 -   10.500: 10                                           
REMARK   3      10.500 -   12.000: 14                                           
REMARK   3      12.000 -   13.500: 3                                            
REMARK   3      13.500 -   15.000: 3                                            
REMARK   3    HISTOGRAM OF DIFFERENCES OVER LIMIT:                              
REMARK   3      15.000 -   30.800: 12                                           
REMARK   3      30.800 -   46.600: 13                                           
REMARK   3      46.600 -   62.400: 18                                           
REMARK   3      62.400 -   78.200: 13                                           
REMARK   3      78.200 -   94.000: 5                                            
REMARK   3      94.000 -  109.800: 0                                            
REMARK   3     109.800 -  125.600: 1                                            
REMARK   3     125.600 -  141.400: 2                                            
REMARK   3     141.400 -  157.200: 0                                            
REMARK   3     157.200 -  173.000: 2                                            
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 5FJ4 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 06-OCT-15.                  
REMARK 100 THE PDBE ID CODE IS EBI-65224.                                       
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 29-JAN-13                          
REMARK 200  TEMPERATURE           (KELVIN) : 173                                
REMARK 200  PH                             : 8.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : DIAMOND                            
REMARK 200  BEAMLINE                       : I03                                
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9763                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL (PILATUS 6M)                 
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS                            
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : IMOSFLM                            
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS                            
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 34011                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.95                               
REMARK 200  RESOLUTION RANGE LOW       (A) : 84.37                              
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 1.1                                
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.9                               
REMARK 200  DATA REDUNDANCY                : 7.5                                
REMARK 200  R MERGE                    (I) : 0.08                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 23.60                              
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.95                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.09                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.7                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 7.6                                
REMARK 200  R MERGE FOR SHELL          (I) : 1.38                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 1.10                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: PDB ENTRY 4C4W                                       
REMARK 200                                                                      
REMARK 200 REMARK: NONE                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 73.68                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.67                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M TRIS HYDROCHLORIDE PH 8.5,         
REMARK 280   2.0 M MONO-AMMONIUM DIHYDROGEN PHOSPHATE                           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 2 2 21                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,-Y,Z+1/2                                             
REMARK 290       3555   -X,Y,-Z+1/2                                             
REMARK 290       4555   X,-Y,-Z                                                 
REMARK 290       5555   X+1/2,Y+1/2,Z                                           
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2                                     
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2                                     
REMARK 290       8555   X+1/2,-Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       74.94950            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       74.94950            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       65.92650            
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       80.61300            
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       65.92650            
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       80.61300            
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       74.94950            
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       65.92650            
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000       80.61300            
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       74.94950            
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       65.92650            
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000       80.61300            
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PQS                                                   
REMARK 350 TOTAL BURIED SURFACE AREA: 4800 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 24320 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -12.4 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PQS                                                   
REMARK 350 TOTAL BURIED SURFACE AREA: 4730 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 24300 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -16.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F, G, H                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     VAL A     3                                                      
REMARK 465     PRO A     4                                                      
REMARK 465     GLU A     5                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     VAL B     3                                                      
REMARK 465     PRO B     4                                                      
REMARK 465     GLU B     5                                                      
REMARK 465     GLY C    -3                                                      
REMARK 465     PRO C    -2                                                      
REMARK 465     GLU C    -1                                                      
REMARK 465     GLN C   118                                                      
REMARK 465     LYS C   119                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     VAL E     3                                                      
REMARK 465     PRO E     4                                                      
REMARK 465     GLU E     5                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ALA F     2                                                      
REMARK 465     VAL F     3                                                      
REMARK 465     PRO F     4                                                      
REMARK 465     GLU F     5                                                      
REMARK 465     GLY G    -3                                                      
REMARK 465     PRO G    -2                                                      
REMARK 465     GLU G    -1                                                      
REMARK 465     GLN G   118                                                      
REMARK 465     LYS G   119                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLN B  39    CG   CD   OE1  NE2                                  
REMARK 470     ARG B  83    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR B  89    OG1  CG2                                            
REMARK 470     GLN F  39    CG   CD   OE1  NE2                                  
REMARK 470     ARG F  83    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR F  89    OG1  CG2                                            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    ALA A    95     N    GLY A    99              2.19            
REMARK 500   O    MET B    97     N    GLY B    99              1.94            
REMARK 500   O    THR C    36     OE1  GLU C    40              2.08            
REMARK 500   O    GLY C    42     NZ   LYS G    27              2.17            
REMARK 500   NH1  ARG C   104     O    GLY G   101              2.01            
REMARK 500   O    ALA E    95     N    GLY E    99              2.18            
REMARK 500   NH2  ARG F    47     O    LYS F    98              2.19            
REMARK 500   O    ALA G    38     NE   ARG G    41              1.97            
REMARK 500   OD1  ASP G    81     NH1  ARG G    84              2.20            
REMARK 500   O    VAL G   111     NZ   LYS G   115              1.68            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    ARG B  52   CZ    ARG B  52   NH2    -0.083                       
REMARK 500    ARG B  52   NE    ARG B  52   CZ     -0.090                       
REMARK 500    GLU C  14   CD    GLU C  14   OE1    -0.088                       
REMARK 500    GLU C  14   CG    GLU C  14   CD     -0.107                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LYS A  60   CD  -  CE  -  NZ  ANGL. DEV. = -29.1 DEGREES          
REMARK 500    LYS B  98   CD  -  CE  -  NZ  ANGL. DEV. = -14.8 DEGREES          
REMARK 500    LEU C  16   CA  -  CB  -  CG  ANGL. DEV. =  16.3 DEGREES          
REMARK 500    VAL C  47   CG1 -  CB  -  CG2 ANGL. DEV. =  10.0 DEGREES          
REMARK 500    LEU C  64   CA  -  CB  -  CG  ANGL. DEV. = -15.1 DEGREES          
REMARK 500    LEU C  64   CB  -  CG  -  CD2 ANGL. DEV. = -16.4 DEGREES          
REMARK 500    CYS C  66   CA  -  CB  -  SG  ANGL. DEV. =  -6.8 DEGREES          
REMARK 500    LEU C 103   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500      A D  12   C8  -  N9  -  C4  ANGL. DEV. =   2.6 DEGREES          
REMARK 500      C D  16   N1  -  C2  -  O2  ANGL. DEV. =  -3.7 DEGREES          
REMARK 500    LYS E  20   CB  -  CG  -  CD  ANGL. DEV. = -22.3 DEGREES          
REMARK 500    LYS E  20   CD  -  CE  -  NZ  ANGL. DEV. = -16.8 DEGREES          
REMARK 500    LEU F  44   CB  -  CG  -  CD2 ANGL. DEV. =  11.5 DEGREES          
REMARK 500    ILE F  58   CG1 -  CB  -  CG2 ANGL. DEV. = -16.1 DEGREES          
REMARK 500    ASP F  90   CB  -  CG  -  OD1 ANGL. DEV. =   5.7 DEGREES          
REMARK 500    ARG G  41   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.8 DEGREES          
REMARK 500    ARG G  41   NE  -  CZ  -  NH2 ANGL. DEV. =   5.0 DEGREES          
REMARK 500    LEU G  43   CA  -  CB  -  CG  ANGL. DEV. =  28.5 DEGREES          
REMARK 500    LEU G  43   CB  -  CG  -  CD1 ANGL. DEV. =  14.8 DEGREES          
REMARK 500    LEU G  46   CA  -  CB  -  CG  ANGL. DEV. =  17.0 DEGREES          
REMARK 500    GLU G  51   CB  -  CA  -  C   ANGL. DEV. = -13.7 DEGREES          
REMARK 500    LEU G 103   CA  -  CB  -  CG  ANGL. DEV. =  16.8 DEGREES          
REMARK 500    ARG G 104   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.4 DEGREES          
REMARK 500    LYS G 115   CB  -  CA  -  C   ANGL. DEV. = -14.7 DEGREES          
REMARK 500      C H  18   C6  -  N1  -  C2  ANGL. DEV. =   2.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    THR A 100      -48.14     54.89                                   
REMARK 500    PRO B   8      154.64    -47.66                                   
REMARK 500    ASN B  16       22.73     82.05                                   
REMARK 500    LEU B  49      -60.58     45.78                                   
REMARK 500    ARG B  52     -162.22    -68.26                                   
REMARK 500    THR B  89       88.47    -51.24                                   
REMARK 500    MET B  97     -113.59    -60.60                                   
REMARK 500    LYS B  98      -14.22     23.93                                   
REMARK 500    THR B 100       46.25     99.83                                   
REMARK 500    PHE B 101      -36.68   -154.14                                   
REMARK 500    SER C   1      -10.97   -145.96                                   
REMARK 500    SER C  25      -50.70   -135.91                                   
REMARK 500    LEU C  46      135.87    175.36                                   
REMARK 500    VAL C  90     -166.02   -123.28                                   
REMARK 500    GLU C 102       -8.40   -167.45                                   
REMARK 500    LEU C 103       56.13   -108.38                                   
REMARK 500    GLU C 112        3.76    -65.10                                   
REMARK 500    SER E  48      150.82    -46.37                                   
REMARK 500    PRO E  76       85.99    -68.29                                   
REMARK 500    THR E 100      -53.17     61.56                                   
REMARK 500    ASN F  16       61.01     66.50                                   
REMARK 500    ASP F  42      126.48    165.75                                   
REMARK 500    SER F  48     -118.17   -109.25                                   
REMARK 500    LYS F  60      -78.12    -97.55                                   
REMARK 500    LYS F  88      115.34     55.39                                   
REMARK 500    ASP F  90       74.43     53.09                                   
REMARK 500    LYS F  98     -170.27     83.25                                   
REMARK 500    SER G   1      -14.30   -145.65                                   
REMARK 500    LEU G  46      135.82    179.65                                   
REMARK 500    ASP G  52       33.21    -99.93                                   
REMARK 500    ASN G  99      144.63   -178.82                                   
REMARK 500    LEU G 103       67.99   -111.58                                   
REMARK 500    LYS G 115      -72.93     -0.69                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 VAL C   53     ASP C   54                 -132.78                    
REMARK 500 ASP C   54     PRO C   55                  141.10                    
REMARK 500 LYS F   88     THR F   89                  -32.16                    
REMARK 500 PRO G    8     GLU G    9                 -146.36                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    VAL G 111        -11.26                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 5FJ0   RELATED DB: PDB                                   
REMARK 900  STRUCTURE OF THE STANDARD KINK TURN HMKT-7 AS SIMPLE                
REMARK 900   DUPLEX IN P4222 SPACE GROUP                                        
REMARK 900 RELATED ID: 5FJ1   RELATED DB: PDB                                   
REMARK 900  STRUCTURE OF THE STANDARD KINK TURN HMKT-7 AS STEM                  
REMARK 900  LOOP IN P212121 SPACE GROUP                                         
REMARK 900 RELATED ID: 5FJC   RELATED DB: PDB                                   
REMARK 900  SAM-I RIBOSWITCH BEARING THE H. MARISMORTUI KT-7                    
REMARK 900  VARIANT C-2BU                                                       
DBREF  5FJ4 A    1   102  UNP    P09012   SNRPA_HUMAN      1    102             
DBREF  5FJ4 B    1   102  UNP    P09012   SNRPA_HUMAN      1    102             
DBREF  5FJ4 C    5   119  UNP    O29494   RL7A_ARCFU       5    119             
DBREF  5FJ4 D    1    35  PDB    5FJ4     5FJ4             1     35             
DBREF  5FJ4 E    1   102  UNP    P09012   SNRPA_HUMAN      1    102             
DBREF  5FJ4 F    1   102  UNP    P09012   SNRPA_HUMAN      1    102             
DBREF  5FJ4 G    5   119  UNP    O29494   RL7A_ARCFU       5    119             
DBREF  5FJ4 H    1    35  PDB    5FJ4     5FJ4             1     35             
SEQADV 5FJ4 HIS A   31  UNP  P09012    TYR    31 CONFLICT                       
SEQADV 5FJ4 ARG A   36  UNP  P09012    GLN    36 CONFLICT                       
SEQADV 5FJ4 HIS B   31  UNP  P09012    TYR    31 CONFLICT                       
SEQADV 5FJ4 ARG B   36  UNP  P09012    GLN    36 CONFLICT                       
SEQADV 5FJ4 GLY C   -3  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 PRO C   -2  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 GLU C   -1  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 ALA C    0  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 SER C    1  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 TYR C    2  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 VAL C    3  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 LYS C    4  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 HIS E   31  UNP  P09012    TYR    31 CONFLICT                       
SEQADV 5FJ4 ARG E   36  UNP  P09012    GLN    36 CONFLICT                       
SEQADV 5FJ4 HIS F   31  UNP  P09012    TYR    31 CONFLICT                       
SEQADV 5FJ4 ARG F   36  UNP  P09012    GLN    36 CONFLICT                       
SEQADV 5FJ4 GLY G   -3  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 PRO G   -2  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 GLU G   -1  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 ALA G    0  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 SER G    1  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 TYR G    2  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 VAL G    3  UNP  O29494              EXPRESSION TAG                 
SEQADV 5FJ4 LYS G    4  UNP  O29494              EXPRESSION TAG                 
SEQRES   1 C  123  GLY PRO GLU ALA SER TYR VAL LYS PHE GLU VAL PRO GLU          
SEQRES   2 C  123  ASP MET GLN ASN GLU ALA LEU SER LEU LEU GLU LYS VAL          
SEQRES   3 C  123  ARG GLU SER GLY LYS VAL LYS LYS GLY THR ASN GLU THR          
SEQRES   4 C  123  THR LYS ALA VAL GLU ARG GLY LEU ALA LYS LEU VAL TYR          
SEQRES   5 C  123  ILE ALA GLU ASP VAL ASP PRO PRO GLU ILE VAL ALA HIS          
SEQRES   6 C  123  LEU PRO LEU LEU CYS GLU GLU LYS ASN VAL PRO TYR ILE          
SEQRES   7 C  123  TYR VAL LYS SER LYS ASN ASP LEU GLY ARG ALA VAL GLY          
SEQRES   8 C  123  ILE GLU VAL PRO CYS ALA SER ALA ALA ILE ILE ASN GLU          
SEQRES   9 C  123  GLY GLU LEU ARG LYS GLU LEU GLY SER LEU VAL GLU LYS          
SEQRES  10 C  123  ILE LYS GLY LEU GLN LYS                                      
SEQRES   1 G  123  GLY PRO GLU ALA SER TYR VAL LYS PHE GLU VAL PRO GLU          
SEQRES   2 G  123  ASP MET GLN ASN GLU ALA LEU SER LEU LEU GLU LYS VAL          
SEQRES   3 G  123  ARG GLU SER GLY LYS VAL LYS LYS GLY THR ASN GLU THR          
SEQRES   4 G  123  THR LYS ALA VAL GLU ARG GLY LEU ALA LYS LEU VAL TYR          
SEQRES   5 G  123  ILE ALA GLU ASP VAL ASP PRO PRO GLU ILE VAL ALA HIS          
SEQRES   6 G  123  LEU PRO LEU LEU CYS GLU GLU LYS ASN VAL PRO TYR ILE          
SEQRES   7 G  123  TYR VAL LYS SER LYS ASN ASP LEU GLY ARG ALA VAL GLY          
SEQRES   8 G  123  ILE GLU VAL PRO CYS ALA SER ALA ALA ILE ILE ASN GLU          
SEQRES   9 G  123  GLY GLU LEU ARG LYS GLU LEU GLY SER LEU VAL GLU LYS          
SEQRES  10 G  123  ILE LYS GLY LEU GLN LYS                                      
SEQRES   1 D   35    G   A   G   G   G   A   G   C   G   C   C   A   U          
SEQRES   2 D   35    U   G   C   A   C   U   C   C   G   G   U   G   C          
SEQRES   3 D   35    G   A   A   G   A   A   C   U   C                          
SEQRES   1 H   35    G   A   G   G   G   A   G   C   G   C   C   A   U          
SEQRES   2 H   35    U   G   C   A   C   U   C   C   G   G   U   G   C          
SEQRES   3 H   35    G   A   A   G   A   A   C   U   C                          
SEQRES   1 A  102  MET ALA VAL PRO GLU THR ARG PRO ASN HIS THR ILE TYR          
SEQRES   2 A  102  ILE ASN ASN LEU ASN GLU LYS ILE LYS LYS ASP GLU LEU          
SEQRES   3 A  102  LYS LYS SER LEU HIS ALA ILE PHE SER ARG PHE GLY GLN          
SEQRES   4 A  102  ILE LEU ASP ILE LEU VAL SER ARG SER LEU LYS MET ARG          
SEQRES   5 A  102  GLY GLN ALA PHE VAL ILE PHE LYS GLU VAL SER SER ALA          
SEQRES   6 A  102  THR ASN ALA LEU ARG SER MET GLN GLY PHE PRO PHE TYR          
SEQRES   7 A  102  ASP LYS PRO MET ARG ILE GLN TYR ALA LYS THR ASP SER          
SEQRES   8 A  102  ASP ILE ILE ALA LYS MET LYS GLY THR PHE VAL                  
SEQRES   1 B  102  MET ALA VAL PRO GLU THR ARG PRO ASN HIS THR ILE TYR          
SEQRES   2 B  102  ILE ASN ASN LEU ASN GLU LYS ILE LYS LYS ASP GLU LEU          
SEQRES   3 B  102  LYS LYS SER LEU HIS ALA ILE PHE SER ARG PHE GLY GLN          
SEQRES   4 B  102  ILE LEU ASP ILE LEU VAL SER ARG SER LEU LYS MET ARG          
SEQRES   5 B  102  GLY GLN ALA PHE VAL ILE PHE LYS GLU VAL SER SER ALA          
SEQRES   6 B  102  THR ASN ALA LEU ARG SER MET GLN GLY PHE PRO PHE TYR          
SEQRES   7 B  102  ASP LYS PRO MET ARG ILE GLN TYR ALA LYS THR ASP SER          
SEQRES   8 B  102  ASP ILE ILE ALA LYS MET LYS GLY THR PHE VAL                  
SEQRES   1 E  102  MET ALA VAL PRO GLU THR ARG PRO ASN HIS THR ILE TYR          
SEQRES   2 E  102  ILE ASN ASN LEU ASN GLU LYS ILE LYS LYS ASP GLU LEU          
SEQRES   3 E  102  LYS LYS SER LEU HIS ALA ILE PHE SER ARG PHE GLY GLN          
SEQRES   4 E  102  ILE LEU ASP ILE LEU VAL SER ARG SER LEU LYS MET ARG          
SEQRES   5 E  102  GLY GLN ALA PHE VAL ILE PHE LYS GLU VAL SER SER ALA          
SEQRES   6 E  102  THR ASN ALA LEU ARG SER MET GLN GLY PHE PRO PHE TYR          
SEQRES   7 E  102  ASP LYS PRO MET ARG ILE GLN TYR ALA LYS THR ASP SER          
SEQRES   8 E  102  ASP ILE ILE ALA LYS MET LYS GLY THR PHE VAL                  
SEQRES   1 F  102  MET ALA VAL PRO GLU THR ARG PRO ASN HIS THR ILE TYR          
SEQRES   2 F  102  ILE ASN ASN LEU ASN GLU LYS ILE LYS LYS ASP GLU LEU          
SEQRES   3 F  102  LYS LYS SER LEU HIS ALA ILE PHE SER ARG PHE GLY GLN          
SEQRES   4 F  102  ILE LEU ASP ILE LEU VAL SER ARG SER LEU LYS MET ARG          
SEQRES   5 F  102  GLY GLN ALA PHE VAL ILE PHE LYS GLU VAL SER SER ALA          
SEQRES   6 F  102  THR ASN ALA LEU ARG SER MET GLN GLY PHE PRO PHE TYR          
SEQRES   7 F  102  ASP LYS PRO MET ARG ILE GLN TYR ALA LYS THR ASP SER          
SEQRES   8 F  102  ASP ILE ILE ALA LYS MET LYS GLY THR PHE VAL                  
HELIX    1   1 LYS A   22  SER A   35  1                                  14    
HELIX    2   2 ARG A   36  GLY A   38  5                                   3    
HELIX    3   3 GLU A   61  MET A   72  1                                  12    
HELIX    4   4 SER A   91  GLY A   99  1                                   9    
HELIX    5   5 LYS B   22  SER B   35  1                                  14    
HELIX    6   6 ARG B   36  GLY B   38  5                                   3    
HELIX    7   7 GLU B   61  GLN B   73  1                                  13    
HELIX    8   8 ASP B   90  MET B   97  1                                   8    
HELIX    9   9 PRO C    8  ARG C   23  1                                  16    
HELIX   10  10 GLY C   31  ARG C   41  1                                  11    
HELIX   11  11 PRO C   56  GLU C   68  1                                  13    
HELIX   12  12 SER C   78  GLY C   87  1                                  10    
HELIX   13  13 LEU C  103  LYS C  115  1                                  13    
HELIX   14  14 LYS E   22  SER E   35  1                                  14    
HELIX   15  15 ARG E   36  GLY E   38  5                                   3    
HELIX   16  16 GLU E   61  MET E   72  1                                  12    
HELIX   17  17 SER E   91  GLY E   99  1                                   9    
HELIX   18  18 LYS F   22  SER F   35  1                                  14    
HELIX   19  19 ARG F   36  GLY F   38  5                                   3    
HELIX   20  20 GLU F   61  GLN F   73  1                                  13    
HELIX   21  21 SER F   91  MET F   97  1                                   7    
HELIX   22  22 PRO G    8  LYS G   21  1                                  14    
HELIX   23  23 GLY G   31  ARG G   41  1                                  11    
HELIX   24  24 PRO G   55  VAL G   59  5                                   5    
HELIX   25  25 HIS G   61  LYS G   69  1                                   9    
HELIX   26  26 SER G   78  GLY G   87  1                                  10    
HELIX   27  27 ARG G  104  LYS G  115  1                                  12    
SHEET    1  AA 4 ILE A  40  VAL A  45  0                                        
SHEET    2  AA 4 GLN A  54  PHE A  59 -1  O  PHE A  56   N  LEU A  44           
SHEET    3  AA 4 THR A  11  ASN A  15 -1  O  ILE A  12   N  VAL A  57           
SHEET    4  AA 4 ARG A  83  TYR A  86 -1  O  ARG A  83   N  ASN A  15           
SHEET    1  BA 4 ILE B  40  VAL B  45  0                                        
SHEET    2  BA 4 GLN B  54  PHE B  59 -1  O  PHE B  56   N  LEU B  44           
SHEET    3  BA 4 THR B  11  ASN B  15 -1  O  ILE B  12   N  VAL B  57           
SHEET    4  BA 4 ARG B  83  TYR B  86 -1  O  ARG B  83   N  ASN B  15           
SHEET    1  BB 2 PRO B  76  PHE B  77  0                                        
SHEET    2  BB 2 LYS B  80  PRO B  81 -1  O  LYS B  80   N  PHE B  77           
SHEET    1  CA 4 VAL C  28  LYS C  30  0                                        
SHEET    2  CA 4 SER C  94  ILE C  97 -1  O  ALA C  96   N  LYS C  29           
SHEET    3  CA 4 LEU C  46  ALA C  50 -1  O  LEU C  46   N  ILE C  97           
SHEET    4  CA 4 TYR C  73  VAL C  76  1  O  ILE C  74   N  ILE C  49           
SHEET    1  EA 4 ILE E  40  VAL E  45  0                                        
SHEET    2  EA 4 ALA E  55  PHE E  59 -1  O  PHE E  56   N  LEU E  44           
SHEET    3  EA 4 THR E  11  ASN E  15 -1  O  ILE E  12   N  VAL E  57           
SHEET    4  EA 4 ARG E  83  TYR E  86 -1  O  ARG E  83   N  ASN E  15           
SHEET    1  FA 4 ILE F  40  VAL F  45  0                                        
SHEET    2  FA 4 GLN F  54  PHE F  59 -1  O  PHE F  56   N  LEU F  44           
SHEET    3  FA 4 THR F  11  ASN F  15 -1  O  ILE F  12   N  VAL F  57           
SHEET    4  FA 4 ARG F  83  TYR F  86 -1  O  ARG F  83   N  ASN F  15           
SHEET    1  FB 2 PRO F  76  PHE F  77  0                                        
SHEET    2  FB 2 LYS F  80  PRO F  81 -1  O  LYS F  80   N  PHE F  77           
SHEET    1  GA 4 LYS G  27  LYS G  30  0                                        
SHEET    2  GA 4 SER G  94  ASN G  99 -1  O  ALA G  96   N  LYS G  29           
SHEET    3  GA 4 LEU G  46  ALA G  50 -1  O  LEU G  46   N  ILE G  97           
SHEET    4  GA 4 TYR G  73  VAL G  76  1  O  ILE G  74   N  ILE G  49           
CISPEP   1 GLY A   99    THR A  100          0        12.46                     
CISPEP   2 ARG B   47    SER B   48          0       -11.53                     
CISPEP   3 THR B  100    PHE B  101          0        10.58                     
CISPEP   4 ALA C    0    SER C    1          0        -8.17                     
CISPEP   5 GLY E   99    THR E  100          0        12.93                     
CISPEP   6 ARG F   47    SER F   48          0         6.08                     
CISPEP   7 ALA G    0    SER G    1          0        -0.96                     
CRYST1  131.853  161.226  149.899  90.00  90.00  90.00 C 2 2 21     32          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.007584  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.006202  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.006671        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system