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Database: PDB
Entry: 5G04
LinkDB: 5G04
Original site: 5G04 
HEADER    CELL CYCLE                              16-MAR-16   5G04              
TITLE     STRUCTURE OF THE HUMAN APC-CDC20-HSL1 COMPLEX                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1;                      
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: APC1, CYCLOSOME SUBUNIT 1, MITOTIC CHECKPOINT REGULATOR,    
COMPND   5  TESTIS-SPECIFIC GENE 24 PROTEIN, APC1;                              
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 11;                     
COMPND   9 CHAIN: B;                                                            
COMPND  10 SYNONYM: APC11, CYCLOSOME SUBUNIT 11, HEPATOCELLULAR CARCINOMA-      
COMPND  11  ASSOCIATED RING FINGER PROTEIN, APC11;                              
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: CELL DIVISION CYCLE PROTEIN 23 HOMOLOG;                    
COMPND  15 CHAIN: C, P;                                                         
COMPND  16 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME       
COMPND  17  SUBUNIT 8, APC8;                                                    
COMPND  18 ENGINEERED: YES;                                                     
COMPND  19 MOL_ID: 4;                                                           
COMPND  20 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 15;                     
COMPND  21 CHAIN: D;                                                            
COMPND  22 SYNONYM: APC15;                                                      
COMPND  23 ENGINEERED: YES;                                                     
COMPND  24 MOL_ID: 5;                                                           
COMPND  25 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 16;                     
COMPND  26 CHAIN: E;                                                            
COMPND  27 SYNONYM: APC16, CYCLOSOME SUBUNIT 16, APC16;                         
COMPND  28 ENGINEERED: YES;                                                     
COMPND  29 MOL_ID: 6;                                                           
COMPND  30 MOLECULE: CELL DIVISION CYCLE PROTEIN 27 HOMOLOG;                    
COMPND  31 CHAIN: F, H;                                                         
COMPND  32 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 3, APC3, CDC27 HOMOLOG,  
COMPND  33  CDC27HS, H-NUC, APC3;                                               
COMPND  34 ENGINEERED: YES;                                                     
COMPND  35 MOL_ID: 7;                                                           
COMPND  36 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26;                  
COMPND  37 CHAIN: G, W;                                                         
COMPND  38 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL          
COMPND  39  DIVISION CYCLE PROTEIN 26 HOMOLOG, APC12;                           
COMPND  40 ENGINEERED: YES;                                                     
COMPND  41 MOL_ID: 8;                                                           
COMPND  42 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 4;                      
COMPND  43 CHAIN: I;                                                            
COMPND  44 SYNONYM: APC4, CYCLOSOME SUBUNIT 4, APC4;                            
COMPND  45 ENGINEERED: YES;                                                     
COMPND  46 MOL_ID: 9;                                                           
COMPND  47 MOLECULE: CELL DIVISION CYCLE PROTEIN 16 HOMOLOG;                    
COMPND  48 CHAIN: J, K;                                                         
COMPND  49 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG,  
COMPND  50  CDC16HS, CYCLOSOME SUBUNIT 6, APC6;                                 
COMPND  51 ENGINEERED: YES;                                                     
COMPND  52 MOL_ID: 10;                                                          
COMPND  53 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 10;                     
COMPND  54 CHAIN: L;                                                            
COMPND  55 SYNONYM: APC10, CYCLOSOME SUBUNIT 10, APC10;                         
COMPND  56 ENGINEERED: YES;                                                     
COMPND  57 MOL_ID: 11;                                                          
COMPND  58 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 13;                     
COMPND  59 CHAIN: M;                                                            
COMPND  60 SYNONYM: APC13, CYCLOSOME SUBUNIT 13, APC13;                         
COMPND  61 ENGINEERED: YES;                                                     
COMPND  62 MOL_ID: 12;                                                          
COMPND  63 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 2;                      
COMPND  64 CHAIN: N;                                                            
COMPND  65 SYNONYM: APC2, CYCLOSOME SUBUNIT 2, APC2;                            
COMPND  66 ENGINEERED: YES;                                                     
COMPND  67 MOL_ID: 13;                                                          
COMPND  68 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 5;                      
COMPND  69 CHAIN: O;                                                            
COMPND  70 SYNONYM: APC5, CYCLOSOME SUBUNIT 5, APC5;                            
COMPND  71 ENGINEERED: YES;                                                     
COMPND  72 MOL_ID: 14;                                                          
COMPND  73 MOLECULE: CELL DIVISION CYCLE PROTEIN 20 HOMOLOG;                    
COMPND  74 CHAIN: R;                                                            
COMPND  75 SYNONYM: P55CDC, CDC20;                                              
COMPND  76 ENGINEERED: YES;                                                     
COMPND  77 MOL_ID: 15;                                                          
COMPND  78 MOLECULE: PROBABLE SERINE/THREONINE-PROTEIN KINASE HSL1;             
COMPND  79 CHAIN: S;                                                            
COMPND  80 FRAGMENT: RESIDUES 667-872;                                          
COMPND  81 SYNONYM: HSL1;                                                       
COMPND  82 EC: 2.7.11.1;                                                        
COMPND  83 ENGINEERED: YES;                                                     
COMPND  84 MOL_ID: 16;                                                          
COMPND  85 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 7;                      
COMPND  86 CHAIN: X, Y;                                                         
COMPND  87 SYNONYM: APC7, CYCLOSOME SUBUNIT 7, APC7;                            
COMPND  88 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE   6 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE  10 MOL_ID: 2;                                                           
SOURCE  11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  12 ORGANISM_COMMON: HUMAN;                                              
SOURCE  13 ORGANISM_TAXID: 9606;                                                
SOURCE  14 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  15 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  17 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  18 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE  19 MOL_ID: 3;                                                           
SOURCE  20 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  21 ORGANISM_COMMON: HUMAN;                                              
SOURCE  22 ORGANISM_TAXID: 9606;                                                
SOURCE  23 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  24 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE  25 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  26 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  27 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE  28 MOL_ID: 4;                                                           
SOURCE  29 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  30 ORGANISM_COMMON: HUMAN;                                              
SOURCE  31 ORGANISM_TAXID: 9606;                                                
SOURCE  32 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  33 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE  34 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  35 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  36 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE  37 MOL_ID: 5;                                                           
SOURCE  38 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  39 ORGANISM_COMMON: HUMAN;                                              
SOURCE  40 ORGANISM_TAXID: 9606;                                                
SOURCE  41 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  42 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE  43 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  44 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  45 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE  46 MOL_ID: 6;                                                           
SOURCE  47 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  48 ORGANISM_COMMON: HUMAN;                                              
SOURCE  49 ORGANISM_TAXID: 9606;                                                
SOURCE  50 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  51 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE  52 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  53 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  54 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE  55 MOL_ID: 7;                                                           
SOURCE  56 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  57 ORGANISM_COMMON: HUMAN;                                              
SOURCE  58 ORGANISM_TAXID: 9606;                                                
SOURCE  59 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  60 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE  61 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  62 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  63 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE  64 MOL_ID: 8;                                                           
SOURCE  65 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  66 ORGANISM_COMMON: HUMAN;                                              
SOURCE  67 ORGANISM_TAXID: 9606;                                                
SOURCE  68 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  69 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE  70 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  71 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  72 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE  73 MOL_ID: 9;                                                           
SOURCE  74 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  75 ORGANISM_COMMON: HUMAN;                                              
SOURCE  76 ORGANISM_TAXID: 9606;                                                
SOURCE  77 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  78 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE  79 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  80 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  81 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE  82 MOL_ID: 10;                                                          
SOURCE  83 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  84 ORGANISM_COMMON: HUMAN;                                              
SOURCE  85 ORGANISM_TAXID: 9606;                                                
SOURCE  86 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  87 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE  88 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  89 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  90 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE  91 MOL_ID: 11;                                                          
SOURCE  92 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  93 ORGANISM_COMMON: HUMAN;                                              
SOURCE  94 ORGANISM_TAXID: 9606;                                                
SOURCE  95 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE  96 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE  97 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE  98 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  99 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE 100 MOL_ID: 12;                                                          
SOURCE 101 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 102 ORGANISM_COMMON: HUMAN;                                              
SOURCE 103 ORGANISM_TAXID: 9606;                                                
SOURCE 104 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE 105 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE 106 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE 107 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE 108 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE 109 MOL_ID: 13;                                                          
SOURCE 110 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 111 ORGANISM_COMMON: HUMAN;                                              
SOURCE 112 ORGANISM_TAXID: 9606;                                                
SOURCE 113 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE 114 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE 115 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE 116 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE 117 EXPRESSION_SYSTEM_PLASMID: PF1, PU1;                                 
SOURCE 118 MOL_ID: 14;                                                          
SOURCE 119 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 120 ORGANISM_COMMON: HUMAN;                                              
SOURCE 121 ORGANISM_TAXID: 9606;                                                
SOURCE 122 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE 123 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE 124 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE 125 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE 126 EXPRESSION_SYSTEM_PLASMID: MODIFIED PFASTBAC HTA;                    
SOURCE 127 MOL_ID: 15;                                                          
SOURCE 128 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 129 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 130 ORGANISM_TAXID: 4932;                                                
SOURCE 131 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE 132 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE 133 EXPRESSION_SYSTEM_PLASMID: PET28A;                                   
SOURCE 134 MOL_ID: 16;                                                          
SOURCE 135 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 136 ORGANISM_COMMON: HUMAN;                                              
SOURCE 137 ORGANISM_TAXID: 9606;                                                
SOURCE 138 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;                            
SOURCE 139 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;                             
SOURCE 140 EXPRESSION_SYSTEM_TAXID: 7108;                                       
SOURCE 141 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE 142 EXPRESSION_SYSTEM_PLASMID: PF1, PU1                                  
KEYWDS    CELL CYCLE, PHOSPHORYLATION, MITOSIS, UBIQUITINATION                  
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    S.ZHANG,L.CHANG,C.ALFIERI,Z.ZHANG,J.YANG,S.MASLEN,M.SKEHEL,D.BARFORD  
REVDAT   1   25-MAY-16 5G04    0                                                
JRNL        AUTH   S.ZHANG,L.CHANG,C.ALFIERI,Z.ZHANG,J.YANG,S.MASLEN,M.SKEHEL,  
JRNL        AUTH 2 D.BARFORD                                                    
JRNL        TITL   MOLECULAR MECHANISM OF APC/C ACTIVATION BY MITOTIC           
JRNL        TITL 2 PHOSPHORYLATION.                                             
JRNL        REF    NATURE                        V. 533   260 2016              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   27120157                                                     
JRNL        DOI    10.1038/NATURE17973                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.8.0147                                      
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,                      
REMARK   3                 STEINER,NICHOLLS,WINN,LONG,VAGIN                     
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD WITH PHASES                
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 4.00                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 228.48                         
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NONE                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 100.00                         
REMARK   3   NUMBER OF REFLECTIONS             : 325385                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : NULL                            
REMARK   3   FREE R VALUE TEST SET SELECTION  : NULL                            
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.36213                         
REMARK   3   R VALUE            (WORKING SET) : 0.36213                         
REMARK   3   FREE R VALUE                     : NULL                            
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : NULL                            
REMARK   3   FREE R VALUE TEST SET COUNT      : NULL                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH           : 4.000                        
REMARK   3   BIN RESOLUTION RANGE LOW            : 4.104                        
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 23967                        
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 100.00                       
REMARK   3   BIN R VALUE           (WORKING SET) : 0.488                        
REMARK   3   BIN FREE R VALUE SET COUNT          : 0                            
REMARK   3   BIN FREE R VALUE                    : NULL                         
REMARK   3                                                                      
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 328.126                        
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) :     0.15                                             
REMARK   3    B22 (A**2) :     0.24                                             
REMARK   3    B33 (A**2) :    -0.39                                             
REMARK   3    B12 (A**2) :    -1.24                                             
REMARK   3    B13 (A**2) :     1.20                                             
REMARK   3    B23 (A**2) :    -2.62                                             
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): 1.474         
REMARK   3   ESU BASED ON FREE R VALUE                       (A): NULL          
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.581         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 43.990        
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.920                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : NULL                          
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 66902 ; 0.012 ; 0.019       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 90616 ; 1.781 ; 1.959       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  8252 ; 6.846 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):  2962 ;35.627 ;23.883       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES): 11477 ;21.963 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   387 ;18.582 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3): 10214 ; 0.130 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 49952 ; 0.008 ; 0.021       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2): 33233 ;26.536 ;32.711       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 41407 ;44.547 ;48.967       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2): 33669 ;22.133 ;33.280       
REMARK   3   LONG RANGE B REFINED ATOMS (A**2)    :419307 ;78.584 ; NULL        
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NCS TYPE: LOCAL                                                    
REMARK   3   NUMBER OF DIFFERENT NCS PAIRS  :   5                               
REMARK   3  GROUP  CHAIN1    RANGE     CHAIN2     RANGE    COUNT RMS  WEIGHT    
REMARK   3    1     C    26    537       P    26    537   30076  0.15  0.04     
REMARK   3    2     F     5    766       H     5    766   31352  0.10  0.04     
REMARK   3    3     G     1     25       W     1     25    1226  0.14  0.04     
REMARK   3    4     J     2    526       K     2    526   29636  0.15  0.04     
REMARK   3    5     X    36    539       Y    36    539   30882  0.06  0.04     
REMARK   3                                                                      
REMARK   3  TWIN DETAILS                                                        
REMARK   3   NUMBER OF TWIN DOMAINS  : NULL                                     
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED :  MASK                                                
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   :   1.20                                        
REMARK   3   ION PROBE RADIUS   :   0.80                                        
REMARK   3   SHRINKAGE RADIUS   :   0.80                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: U VALUES REFINED INDIVIDUALLY             
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS:  SUBMISSION BASED ON EXPERIMENTAL DATA                
REMARK   3  FROM EMDB EMD-3385. (DEPOSITION ID: 14398).                         
REMARK   4                                                                      
REMARK   4 5G04 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 07-MAY-16.                  
REMARK 100 THE PDBE ID CODE IS EBI-66501.                                       
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : VITREOUS ICE                      
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : NULL                              
REMARK 245   NAME OF SAMPLE                 : RECOMBINANT APC-CDC20- HSL1       
REMARK 245                                    COMPLEX                           
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.15                              
REMARK 245   SAMPLE SUPPORT DETAILS         : CARBON                            
REMARK 245   SAMPLE VITRIFICATION DETAILS   : LIQUID ETHANE                     
REMARK 245   SAMPLE BUFFER                  : 20MM HEPES, 150MM NACL, 0. 5MM    
REMARK 245                                    TCEP                              
REMARK 245   PH                             : 8.0                               
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 30-OCT-15                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : 100                            
REMARK 245   MICROSCOPE MODEL                  : OTHER                          
REMARK 245   DETECTOR TYPE                     : FEI FALCON II (4K X 4K)        
REMARK 245   MINIMUM DEFOCUS (NM)              : 2000                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : 4000                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2                              
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 27                             
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 78000                          
REMARK 245   CALIBRATED MAGNIFICATION          : 78000                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 21-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I,            
REMARK 350                    AND CHAINS: J, K, L, M, N, O, P, R, S,            
REMARK 350                    AND CHAINS: W, X, Y                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     ASN A     3                                                      
REMARK 465     PHE A     4                                                      
REMARK 465     TYR A     5                                                      
REMARK 465     GLU A     6                                                      
REMARK 465     GLU A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     THR A    10                                                      
REMARK 465     GLY A    59                                                      
REMARK 465     SER A    60                                                      
REMARK 465     LEU A    61                                                      
REMARK 465     GLN A    62                                                      
REMARK 465     GLU A    63                                                      
REMARK 465     VAL A    64                                                      
REMARK 465     THR A    65                                                      
REMARK 465     ILE A    66                                                      
REMARK 465     HIS A    67                                                      
REMARK 465     GLU A    68                                                      
REMARK 465     LYS A    69                                                      
REMARK 465     GLN A    70                                                      
REMARK 465     GLN A   135                                                      
REMARK 465     ASP A   136                                                      
REMARK 465     LYS A   137                                                      
REMARK 465     SER A   138                                                      
REMARK 465     GLU A   139                                                      
REMARK 465     LYS A   140                                                      
REMARK 465     ALA A   141                                                      
REMARK 465     TYR A   142                                                      
REMARK 465     SER A   143                                                      
REMARK 465     SER A   144                                                      
REMARK 465     ASN A   145                                                      
REMARK 465     ALA A   193                                                      
REMARK 465     SER A   194                                                      
REMARK 465     SER A   195                                                      
REMARK 465     HIS A   196                                                      
REMARK 465     GLU A   197                                                      
REMARK 465     VAL A   198                                                      
REMARK 465     PRO A   199                                                      
REMARK 465     PRO A   200                                                      
REMARK 465     GLY A   201                                                      
REMARK 465     SER A   202                                                      
REMARK 465     PRO A   203                                                      
REMARK 465     ARG A   204                                                      
REMARK 465     GLU A   205                                                      
REMARK 465     SER A   227                                                      
REMARK 465     GLY A   228                                                      
REMARK 465     SER A   229                                                      
REMARK 465     LEU A   230                                                      
REMARK 465     PHE A   231                                                      
REMARK 465     GLY A   232                                                      
REMARK 465     SER A   233                                                      
REMARK 465     SER A   234                                                      
REMARK 465     ARG A   235                                                      
REMARK 465     VAL A   282                                                      
REMARK 465     LEU A   283                                                      
REMARK 465     LYS A   284                                                      
REMARK 465     PHE A   285                                                      
REMARK 465     SER A   286                                                      
REMARK 465     GLU A   287                                                      
REMARK 465     GLN A   288                                                      
REMARK 465     GLY A   289                                                      
REMARK 465     GLY A   290                                                      
REMARK 465     THR A   291                                                      
REMARK 465     PRO A   292                                                      
REMARK 465     GLN A   293                                                      
REMARK 465     ASN A   294                                                      
REMARK 465     VAL A   295                                                      
REMARK 465     ALA A   296                                                      
REMARK 465     THR A   297                                                      
REMARK 465     SER A   298                                                      
REMARK 465     SER A   299                                                      
REMARK 465     SER A   300                                                      
REMARK 465     LEU A   301                                                      
REMARK 465     THR A   302                                                      
REMARK 465     ALA A   303                                                      
REMARK 465     HIS A   304                                                      
REMARK 465     LEU A   305                                                      
REMARK 465     ARG A   306                                                      
REMARK 465     SER A   307                                                      
REMARK 465     LEU A   308                                                      
REMARK 465     SER A   309                                                      
REMARK 465     LYS A   310                                                      
REMARK 465     GLY A   311                                                      
REMARK 465     ASP A   312                                                      
REMARK 465     SER A   313                                                      
REMARK 465     PRO A   314                                                      
REMARK 465     VAL A   315                                                      
REMARK 465     THR A   316                                                      
REMARK 465     SER A   317                                                      
REMARK 465     PRO A   318                                                      
REMARK 465     PHE A   319                                                      
REMARK 465     GLN A   320                                                      
REMARK 465     ASN A   321                                                      
REMARK 465     TYR A   322                                                      
REMARK 465     SER A   323                                                      
REMARK 465     SER A   324                                                      
REMARK 465     ILE A   325                                                      
REMARK 465     HIS A   326                                                      
REMARK 465     SER A   327                                                      
REMARK 465     GLN A   328                                                      
REMARK 465     SER A   329                                                      
REMARK 465     ARG A   330                                                      
REMARK 465     SER A   331                                                      
REMARK 465     THR A   332                                                      
REMARK 465     SER A   333                                                      
REMARK 465     SER A   334                                                      
REMARK 465     PRO A   335                                                      
REMARK 465     SER A   336                                                      
REMARK 465     LEU A   337                                                      
REMARK 465     HIS A   338                                                      
REMARK 465     SER A   339                                                      
REMARK 465     ARG A   340                                                      
REMARK 465     SER A   341                                                      
REMARK 465     PRO A   342                                                      
REMARK 465     SER A   343                                                      
REMARK 465     ILE A   344                                                      
REMARK 465     SER A   345                                                      
REMARK 465     ASN A   346                                                      
REMARK 465     MET A   347                                                      
REMARK 465     ALA A   348                                                      
REMARK 465     ALA A   349                                                      
REMARK 465     LEU A   350                                                      
REMARK 465     SER A   351                                                      
REMARK 465     ARG A   352                                                      
REMARK 465     ALA A   353                                                      
REMARK 465     HIS A   354                                                      
REMARK 465     SER A   355                                                      
REMARK 465     PRO A   356                                                      
REMARK 465     ALA A   357                                                      
REMARK 465     LEU A   358                                                      
REMARK 465     GLY A   359                                                      
REMARK 465     VAL A   360                                                      
REMARK 465     HIS A   361                                                      
REMARK 465     SER A   362                                                      
REMARK 465     PHE A   363                                                      
REMARK 465     SER A   364                                                      
REMARK 465     GLY A   365                                                      
REMARK 465     VAL A   366                                                      
REMARK 465     GLN A   367                                                      
REMARK 465     ARG A   368                                                      
REMARK 465     PHE A   369                                                      
REMARK 465     ASN A   370                                                      
REMARK 465     ILE A   371                                                      
REMARK 465     SER A   372                                                      
REMARK 465     SER A   373                                                      
REMARK 465     HIS A   374                                                      
REMARK 465     ASN A   375                                                      
REMARK 465     GLN A   376                                                      
REMARK 465     SER A   377                                                      
REMARK 465     PRO A   378                                                      
REMARK 465     LYS A   379                                                      
REMARK 465     ARG A   380                                                      
REMARK 465     HIS A   381                                                      
REMARK 465     SER A   382                                                      
REMARK 465     ILE A   383                                                      
REMARK 465     SER A   384                                                      
REMARK 465     HIS A   385                                                      
REMARK 465     SER A   386                                                      
REMARK 465     PRO A   387                                                      
REMARK 465     ASN A   388                                                      
REMARK 465     SER A   389                                                      
REMARK 465     ASN A   390                                                      
REMARK 465     SER A   391                                                      
REMARK 465     ASN A   392                                                      
REMARK 465     GLY A   393                                                      
REMARK 465     SER A   394                                                      
REMARK 465     PHE A   395                                                      
REMARK 465     LEU A   396                                                      
REMARK 465     ALA A   397                                                      
REMARK 465     PRO A   398                                                      
REMARK 465     GLU A   399                                                      
REMARK 465     THR A   400                                                      
REMARK 465     GLU A   401                                                      
REMARK 465     THR A   416                                                      
REMARK 465     ILE A   417                                                      
REMARK 465     THR A   418                                                      
REMARK 465     ASN A   419                                                      
REMARK 465     ILE A   420                                                      
REMARK 465     ARG A   421                                                      
REMARK 465     GLU A   422                                                      
REMARK 465     LYS A   423                                                      
REMARK 465     ASN A   424                                                      
REMARK 465     ASN A   461                                                      
REMARK 465     ASP A   462                                                      
REMARK 465     LYS A   463                                                      
REMARK 465     LEU A   514                                                      
REMARK 465     PRO A   515                                                      
REMARK 465     ALA A   516                                                      
REMARK 465     PRO A   517                                                      
REMARK 465     SER A   518                                                      
REMARK 465     LEU A   519                                                      
REMARK 465     THR A   520                                                      
REMARK 465     MET A   521                                                      
REMARK 465     SER A   522                                                      
REMARK 465     ASN A   523                                                      
REMARK 465     THR A   524                                                      
REMARK 465     MET A   525                                                      
REMARK 465     PRO A   526                                                      
REMARK 465     ARG A   527                                                      
REMARK 465     PRO A   528                                                      
REMARK 465     SER A   529                                                      
REMARK 465     THR A   530                                                      
REMARK 465     PRO A   531                                                      
REMARK 465     LEU A   532                                                      
REMARK 465     ASP A   533                                                      
REMARK 465     GLY A   534                                                      
REMARK 465     VAL A   535                                                      
REMARK 465     SER A   536                                                      
REMARK 465     THR A   537                                                      
REMARK 465     PRO A   538                                                      
REMARK 465     LYS A   539                                                      
REMARK 465     PRO A   540                                                      
REMARK 465     LEU A   541                                                      
REMARK 465     SER A   542                                                      
REMARK 465     LYS A   543                                                      
REMARK 465     LEU A   544                                                      
REMARK 465     LEU A   545                                                      
REMARK 465     GLY A   546                                                      
REMARK 465     SER A   547                                                      
REMARK 465     LEU A   548                                                      
REMARK 465     ASP A   549                                                      
REMARK 465     GLU A   550                                                      
REMARK 465     VAL A   551                                                      
REMARK 465     VAL A   552                                                      
REMARK 465     LEU A   553                                                      
REMARK 465     LEU A   554                                                      
REMARK 465     SER A   555                                                      
REMARK 465     PRO A   556                                                      
REMARK 465     VAL A   557                                                      
REMARK 465     PRO A   558                                                      
REMARK 465     GLU A   559                                                      
REMARK 465     LEU A   560                                                      
REMARK 465     ARG A   561                                                      
REMARK 465     ASP A   562                                                      
REMARK 465     SER A   563                                                      
REMARK 465     SER A   564                                                      
REMARK 465     LYS A   565                                                      
REMARK 465     LEU A   566                                                      
REMARK 465     HIS A   567                                                      
REMARK 465     ASP A   568                                                      
REMARK 465     SER A   569                                                      
REMARK 465     LEU A   570                                                      
REMARK 465     TYR A   571                                                      
REMARK 465     ASN A   572                                                      
REMARK 465     GLU A   573                                                      
REMARK 465     ASP A   574                                                      
REMARK 465     CYS A   575                                                      
REMARK 465     THR A   576                                                      
REMARK 465     PHE A   577                                                      
REMARK 465     GLN A   578                                                      
REMARK 465     GLN A   579                                                      
REMARK 465     LEU A   580                                                      
REMARK 465     GLY A   581                                                      
REMARK 465     ARG A   674                                                      
REMARK 465     LEU A   675                                                      
REMARK 465     ALA A   676                                                      
REMARK 465     TRP A   677                                                      
REMARK 465     THR A   678                                                      
REMARK 465     ARG A   679                                                      
REMARK 465     ASN A   680                                                      
REMARK 465     PHE A   681                                                      
REMARK 465     ASP A   682                                                      
REMARK 465     PHE A   683                                                      
REMARK 465     GLU A   684                                                      
REMARK 465     GLY A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     LEU A   687                                                      
REMARK 465     SER A   688                                                      
REMARK 465     PRO A   689                                                      
REMARK 465     VAL A   690                                                      
REMARK 465     ILE A   691                                                      
REMARK 465     ALA A   692                                                      
REMARK 465     PRO A   693                                                      
REMARK 465     LYS A   694                                                      
REMARK 465     LYS A   695                                                      
REMARK 465     ALA A   696                                                      
REMARK 465     ARG A   697                                                      
REMARK 465     PRO A   698                                                      
REMARK 465     SER A   699                                                      
REMARK 465     GLU A   700                                                      
REMARK 465     THR A   701                                                      
REMARK 465     GLY A   702                                                      
REMARK 465     SER A   703                                                      
REMARK 465     ASP A   704                                                      
REMARK 465     ASP A   705                                                      
REMARK 465     ASP A   706                                                      
REMARK 465     TRP A   707                                                      
REMARK 465     GLU A   708                                                      
REMARK 465     TYR A   709                                                      
REMARK 465     LEU A   710                                                      
REMARK 465     LEU A   711                                                      
REMARK 465     ASN A   712                                                      
REMARK 465     SER A   713                                                      
REMARK 465     ASP A   714                                                      
REMARK 465     TYR A   715                                                      
REMARK 465     HIS A   716                                                      
REMARK 465     GLN A   717                                                      
REMARK 465     ASN A   718                                                      
REMARK 465     VAL A   719                                                      
REMARK 465     GLU A   720                                                      
REMARK 465     SER A   721                                                      
REMARK 465     HIS A   722                                                      
REMARK 465     LEU A   723                                                      
REMARK 465     LEU A   724                                                      
REMARK 465     ASN A   725                                                      
REMARK 465     ARG A   726                                                      
REMARK 465     SER A   727                                                      
REMARK 465     LEU A   728                                                      
REMARK 465     CYS A   729                                                      
REMARK 465     LEU A   730                                                      
REMARK 465     SER A   731                                                      
REMARK 465     PRO A   732                                                      
REMARK 465     SER A   733                                                      
REMARK 465     GLU A   734                                                      
REMARK 465     ALA A   735                                                      
REMARK 465     SER A   736                                                      
REMARK 465     GLN A   737                                                      
REMARK 465     MET A   738                                                      
REMARK 465     LYS A   739                                                      
REMARK 465     ASP A   740                                                      
REMARK 465     GLU A   741                                                      
REMARK 465     ASP A   742                                                      
REMARK 465     PHE A   743                                                      
REMARK 465     SER A   744                                                      
REMARK 465     GLN A   745                                                      
REMARK 465     ASN A   746                                                      
REMARK 465     LEU A   747                                                      
REMARK 465     SER A   748                                                      
REMARK 465     LEU A   749                                                      
REMARK 465     ASP A   750                                                      
REMARK 465     SER A   751                                                      
REMARK 465     ARG A   815                                                      
REMARK 465     THR A   816                                                      
REMARK 465     THR A   817                                                      
REMARK 465     GLY A   818                                                      
REMARK 465     GLN A   819                                                      
REMARK 465     VAL A   820                                                      
REMARK 465     CYS A   821                                                      
REMARK 465     THR A   822                                                      
REMARK 465     ILE A   823                                                      
REMARK 465     ASP A   824                                                      
REMARK 465     PRO A   825                                                      
REMARK 465     GLY A   826                                                      
REMARK 465     GLN A   827                                                      
REMARK 465     THR A   828                                                      
REMARK 465     GLY A   829                                                      
REMARK 465     PHE A   830                                                      
REMARK 465     MET A   831                                                      
REMARK 465     HIS A   832                                                      
REMARK 465     HIS A   833                                                      
REMARK 465     PRO A   834                                                      
REMARK 465     SER A   835                                                      
REMARK 465     PHE A   836                                                      
REMARK 465     GLY A   883                                                      
REMARK 465     ASP A   884                                                      
REMARK 465     GLU A   885                                                      
REMARK 465     SER A   886                                                      
REMARK 465     LEU A   887                                                      
REMARK 465     VAL A   888                                                      
REMARK 465     SER A   889                                                      
REMARK 465     ASP A   890                                                      
REMARK 465     GLU A   891                                                      
REMARK 465     SER A   892                                                      
REMARK 465     SER A   893                                                      
REMARK 465     GLN A   894                                                      
REMARK 465     TYR A   895                                                      
REMARK 465     LEU A   896                                                      
REMARK 465     THR A   897                                                      
REMARK 465     ARG A   898                                                      
REMARK 465     ILE A   899                                                      
REMARK 465     THR A   900                                                      
REMARK 465     ILE A   901                                                      
REMARK 465     ALA A   902                                                      
REMARK 465     PRO A   903                                                      
REMARK 465     GLN A   904                                                      
REMARK 465     LYS A   905                                                      
REMARK 465     LEU A   906                                                      
REMARK 465     GLN A   907                                                      
REMARK 465     VAL A   908                                                      
REMARK 465     GLU A   909                                                      
REMARK 465     GLN A   910                                                      
REMARK 465     GLU A   911                                                      
REMARK 465     GLU A   912                                                      
REMARK 465     ASN A   913                                                      
REMARK 465     ARG A   914                                                      
REMARK 465     PHE A   915                                                      
REMARK 465     SER A   916                                                      
REMARK 465     PHE A   917                                                      
REMARK 465     ARG A   918                                                      
REMARK 465     HIS A   919                                                      
REMARK 465     SER A   920                                                      
REMARK 465     THR A   921                                                      
REMARK 465     SER A   922                                                      
REMARK 465     VAL A   923                                                      
REMARK 465     ALA A   987                                                      
REMARK 465     CYS A   988                                                      
REMARK 465     GLU A   989                                                      
REMARK 465     GLY A   990                                                      
REMARK 465     ASN A   991                                                      
REMARK 465     LEU A   992                                                      
REMARK 465     PRO A   993                                                      
REMARK 465     LYS A   994                                                      
REMARK 465     GLY A   995                                                      
REMARK 465     LYS A   996                                                      
REMARK 465     SER A   997                                                      
REMARK 465     VAL A   998                                                      
REMARK 465     LEU A   999                                                      
REMARK 465     SER A  1000                                                      
REMARK 465     SER A  1001                                                      
REMARK 465     ASP A  1002                                                      
REMARK 465     VAL A  1003                                                      
REMARK 465     PRO A  1004                                                      
REMARK 465     SER A  1005                                                      
REMARK 465     GLY A  1006                                                      
REMARK 465     THR A  1007                                                      
REMARK 465     GLU A  1008                                                      
REMARK 465     THR A  1009                                                      
REMARK 465     GLU A  1010                                                      
REMARK 465     GLU A  1011                                                      
REMARK 465     GLU A  1012                                                      
REMARK 465     ARG A  1334                                                      
REMARK 465     ARG A  1335                                                      
REMARK 465     PHE A  1336                                                      
REMARK 465     GLN A  1337                                                      
REMARK 465     THR A  1338                                                      
REMARK 465     GLY A  1339                                                      
REMARK 465     MET A  1340                                                      
REMARK 465     HIS A  1341                                                      
REMARK 465     ARG A  1342                                                      
REMARK 465     GLU A  1343                                                      
REMARK 465     LYS A  1344                                                      
REMARK 465     HIS A  1345                                                      
REMARK 465     LYS A  1346                                                      
REMARK 465     SER A  1438                                                      
REMARK 465     ILE A  1439                                                      
REMARK 465     SER A  1440                                                      
REMARK 465     LEU A  1441                                                      
REMARK 465     SER A  1442                                                      
REMARK 465     GLU A  1443                                                      
REMARK 465     ILE A  1444                                                      
REMARK 465     GLU A  1445                                                      
REMARK 465     LEU A  1446                                                      
REMARK 465     PRO A  1447                                                      
REMARK 465     CYS A  1448                                                      
REMARK 465     SER A  1449                                                      
REMARK 465     GLU A  1450                                                      
REMARK 465     ASP A  1451                                                      
REMARK 465     SER A  1681                                                      
REMARK 465     LYS A  1682                                                      
REMARK 465     GLY A  1683                                                      
REMARK 465     PRO A  1712                                                      
REMARK 465     MET A  1713                                                      
REMARK 465     GLY A  1714                                                      
REMARK 465     TRP A  1715                                                      
REMARK 465     GLN A  1716                                                      
REMARK 465     SER A  1717                                                      
REMARK 465     LEU A  1718                                                      
REMARK 465     LEU A  1719                                                      
REMARK 465     ALA A  1720                                                      
REMARK 465     GLN A  1721                                                      
REMARK 465     THR A  1722                                                      
REMARK 465     VAL A  1723                                                      
REMARK 465     ALA A  1724                                                      
REMARK 465     ASN A  1725                                                      
REMARK 465     ARG A  1726                                                      
REMARK 465     PRO A  1735                                                      
REMARK 465     GLU A  1736                                                      
REMARK 465     THR A  1737                                                      
REMARK 465     ILE A  1738                                                      
REMARK 465     GLU A  1828                                                      
REMARK 465     ARG A  1829                                                      
REMARK 465     LEU A  1830                                                      
REMARK 465     GLN A  1831                                                      
REMARK 465     ASN A  1832                                                      
REMARK 465     HIS A  1833                                                      
REMARK 465     PRO A  1834                                                      
REMARK 465     LYS A  1835                                                      
REMARK 465     ARG A  1836                                                      
REMARK 465     GLY A  1837                                                      
REMARK 465     LEU A  1838                                                      
REMARK 465     GLY A  1874                                                      
REMARK 465     GLN A  1875                                                      
REMARK 465     PRO A  1876                                                      
REMARK 465     GLN A  1898                                                      
REMARK 465     HIS A  1899                                                      
REMARK 465     LEU A  1900                                                      
REMARK 465     PRO A  1901                                                      
REMARK 465     PRO A  1902                                                      
REMARK 465     ILE A  1903                                                      
REMARK 465     GLY A  1904                                                      
REMARK 465     LEU A  1905                                                      
REMARK 465     GLU A  1906                                                      
REMARK 465     GLY A  1907                                                      
REMARK 465     SER A  1908                                                      
REMARK 465     LEU A  1935                                                      
REMARK 465     LEU A  1936                                                      
REMARK 465     LEU A  1937                                                      
REMARK 465     GLY A  1938                                                      
REMARK 465     ASN A  1939                                                      
REMARK 465     PRO A  1940                                                      
REMARK 465     GLN A  1941                                                      
REMARK 465     PRO A  1942                                                      
REMARK 465     MET A  1943                                                      
REMARK 465     VAL A  1944                                                      
REMARK 465     MET A  1945                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     THR C     5                                                      
REMARK 465     SER C     6                                                      
REMARK 465     MET C     7                                                      
REMARK 465     VAL C     8                                                      
REMARK 465     PRO C     9                                                      
REMARK 465     VAL C    10                                                      
REMARK 465     ALA C    11                                                      
REMARK 465     VAL C    12                                                      
REMARK 465     THR C    13                                                      
REMARK 465     ALA C    14                                                      
REMARK 465     ALA C    15                                                      
REMARK 465     VAL C    16                                                      
REMARK 465     ALA C    17                                                      
REMARK 465     PRO C    18                                                      
REMARK 465     VAL C    19                                                      
REMARK 465     LEU C    20                                                      
REMARK 465     SER C    21                                                      
REMARK 465     ILE C    22                                                      
REMARK 465     ASN C    23                                                      
REMARK 465     SER C    24                                                      
REMARK 465     ASP C    25                                                      
REMARK 465     GLY C   501                                                      
REMARK 465     GLU C   502                                                      
REMARK 465     ILE C   503                                                      
REMARK 465     VAL C   504                                                      
REMARK 465     GLU C   505                                                      
REMARK 465     HIS C   506                                                      
REMARK 465     LEU C   507                                                      
REMARK 465     GLU C   508                                                      
REMARK 465     ASN C   558                                                      
REMARK 465     GLN C   559                                                      
REMARK 465     GLY C   560                                                      
REMARK 465     GLU C   561                                                      
REMARK 465     THR C   562                                                      
REMARK 465     PRO C   563                                                      
REMARK 465     THR C   564                                                      
REMARK 465     THR C   565                                                      
REMARK 465     GLU C   566                                                      
REMARK 465     VAL C   567                                                      
REMARK 465     PRO C   568                                                      
REMARK 465     ALA C   569                                                      
REMARK 465     PRO C   570                                                      
REMARK 465     PHE C   571                                                      
REMARK 465     PHE C   572                                                      
REMARK 465     LEU C   573                                                      
REMARK 465     PRO C   574                                                      
REMARK 465     ALA C   575                                                      
REMARK 465     SER C   576                                                      
REMARK 465     LEU C   577                                                      
REMARK 465     SER C   578                                                      
REMARK 465     ALA C   579                                                      
REMARK 465     ASN C   580                                                      
REMARK 465     ASN C   581                                                      
REMARK 465     THR C   582                                                      
REMARK 465     PRO C   583                                                      
REMARK 465     THR C   584                                                      
REMARK 465     ARG C   585                                                      
REMARK 465     ARG C   586                                                      
REMARK 465     VAL C   587                                                      
REMARK 465     SER C   588                                                      
REMARK 465     PRO C   589                                                      
REMARK 465     LEU C   590                                                      
REMARK 465     ASN C   591                                                      
REMARK 465     LEU C   592                                                      
REMARK 465     SER C   593                                                      
REMARK 465     SER C   594                                                      
REMARK 465     VAL C   595                                                      
REMARK 465     THR C   596                                                      
REMARK 465     PRO C   597                                                      
REMARK 465     MET D     1                                                      
REMARK 465     PRO D    57                                                      
REMARK 465     ALA D    58                                                      
REMARK 465     SER D    59                                                      
REMARK 465     GLU D    60                                                      
REMARK 465     HIS D    61                                                      
REMARK 465     TYR D    62                                                      
REMARK 465     ASP D    63                                                      
REMARK 465     ASP D    64                                                      
REMARK 465     GLU D    65                                                      
REMARK 465     GLU D    66                                                      
REMARK 465     GLU D    67                                                      
REMARK 465     GLU D    68                                                      
REMARK 465     ASP D    69                                                      
REMARK 465     ASP D    70                                                      
REMARK 465     GLU D    71                                                      
REMARK 465     ASP D    72                                                      
REMARK 465     ASP D    73                                                      
REMARK 465     GLU D    74                                                      
REMARK 465     ASP D    75                                                      
REMARK 465     SER D    76                                                      
REMARK 465     GLU D    77                                                      
REMARK 465     GLU D    78                                                      
REMARK 465     ASP D    79                                                      
REMARK 465     SER D    80                                                      
REMARK 465     GLU D    81                                                      
REMARK 465     ASP D    82                                                      
REMARK 465     ASP D    83                                                      
REMARK 465     GLU D    84                                                      
REMARK 465     ASP D    85                                                      
REMARK 465     MET D    86                                                      
REMARK 465     GLN D    87                                                      
REMARK 465     ASP D    88                                                      
REMARK 465     MET D    89                                                      
REMARK 465     ASP D    90                                                      
REMARK 465     GLU D    91                                                      
REMARK 465     MET D    92                                                      
REMARK 465     ASN D    93                                                      
REMARK 465     ASP D    94                                                      
REMARK 465     TYR D    95                                                      
REMARK 465     ASN D    96                                                      
REMARK 465     GLU D    97                                                      
REMARK 465     SER D    98                                                      
REMARK 465     PRO D    99                                                      
REMARK 465     ASP D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     GLY D   102                                                      
REMARK 465     GLU D   103                                                      
REMARK 465     VAL D   104                                                      
REMARK 465     ASN D   105                                                      
REMARK 465     GLU D   106                                                      
REMARK 465     VAL D   107                                                      
REMARK 465     ASP D   108                                                      
REMARK 465     MET D   109                                                      
REMARK 465     GLU D   110                                                      
REMARK 465     GLY D   111                                                      
REMARK 465     ASN D   112                                                      
REMARK 465     GLU D   113                                                      
REMARK 465     GLN D   114                                                      
REMARK 465     ASP D   115                                                      
REMARK 465     GLN D   116                                                      
REMARK 465     ASP D   117                                                      
REMARK 465     GLN D   118                                                      
REMARK 465     TRP D   119                                                      
REMARK 465     MET D   120                                                      
REMARK 465     ILE D   121                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     SER E     4                                                      
REMARK 465     SER E     5                                                      
REMARK 465     SER E     6                                                      
REMARK 465     SER E     7                                                      
REMARK 465     SER E     8                                                      
REMARK 465     SER E     9                                                      
REMARK 465     ALA E    10                                                      
REMARK 465     GLY E    11                                                      
REMARK 465     GLY E    12                                                      
REMARK 465     VAL E    13                                                      
REMARK 465     SER E    14                                                      
REMARK 465     GLY E    15                                                      
REMARK 465     SER E    16                                                      
REMARK 465     SER E    17                                                      
REMARK 465     VAL E    18                                                      
REMARK 465     THR E    19                                                      
REMARK 465     GLY E    20                                                      
REMARK 465     SER E    21                                                      
REMARK 465     GLY E    22                                                      
REMARK 465     PHE E    23                                                      
REMARK 465     SER E    24                                                      
REMARK 465     VAL E    25                                                      
REMARK 465     SER E    26                                                      
REMARK 465     ASP E    27                                                      
REMARK 465     LEU E    28                                                      
REMARK 465     ALA E    29                                                      
REMARK 465     PRO E    30                                                      
REMARK 465     PRO E    31                                                      
REMARK 465     ARG E    32                                                      
REMARK 465     LYS E    33                                                      
REMARK 465     ALA E    34                                                      
REMARK 465     LEU E    35                                                      
REMARK 465     PHE E    36                                                      
REMARK 465     THR E    37                                                      
REMARK 465     TYR E    38                                                      
REMARK 465     PRO E    39                                                      
REMARK 465     LYS E    40                                                      
REMARK 465     GLY E    41                                                      
REMARK 465     ALA E    42                                                      
REMARK 465     GLY E    43                                                      
REMARK 465     GLU E    44                                                      
REMARK 465     MET E    45                                                      
REMARK 465     LEU E    46                                                      
REMARK 465     GLU E    47                                                      
REMARK 465     ASP E    48                                                      
REMARK 465     GLY E    49                                                      
REMARK 465     SER E    50                                                      
REMARK 465     GLU E    51                                                      
REMARK 465     SER E   108                                                      
REMARK 465     SER E   109                                                      
REMARK 465     GLY E   110                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     VAL F     3                                                      
REMARK 465     LEU F     4                                                      
REMARK 465     THR F   171                                                      
REMARK 465     SER F   172                                                      
REMARK 465     LEU F   173                                                      
REMARK 465     GLN F   174                                                      
REMARK 465     ASN F   175                                                      
REMARK 465     PHE F   176                                                      
REMARK 465     SER F   177                                                      
REMARK 465     ASN F   178                                                      
REMARK 465     CYS F   179                                                      
REMARK 465     LEU F   180                                                      
REMARK 465     PRO F   181                                                      
REMARK 465     ASN F   182                                                      
REMARK 465     SER F   183                                                      
REMARK 465     CYS F   184                                                      
REMARK 465     THR F   185                                                      
REMARK 465     THR F   186                                                      
REMARK 465     GLN F   187                                                      
REMARK 465     VAL F   188                                                      
REMARK 465     PRO F   189                                                      
REMARK 465     ASN F   190                                                      
REMARK 465     HIS F   191                                                      
REMARK 465     SER F   192                                                      
REMARK 465     LEU F   193                                                      
REMARK 465     SER F   194                                                      
REMARK 465     HIS F   195                                                      
REMARK 465     ARG F   196                                                      
REMARK 465     GLN F   197                                                      
REMARK 465     PRO F   198                                                      
REMARK 465     GLU F   199                                                      
REMARK 465     THR F   200                                                      
REMARK 465     VAL F   201                                                      
REMARK 465     LEU F   202                                                      
REMARK 465     THR F   203                                                      
REMARK 465     GLU F   204                                                      
REMARK 465     THR F   205                                                      
REMARK 465     PRO F   206                                                      
REMARK 465     GLN F   207                                                      
REMARK 465     ASP F   208                                                      
REMARK 465     THR F   209                                                      
REMARK 465     ILE F   210                                                      
REMARK 465     GLU F   211                                                      
REMARK 465     LEU F   212                                                      
REMARK 465     ASN F   213                                                      
REMARK 465     ARG F   214                                                      
REMARK 465     LEU F   215                                                      
REMARK 465     ASN F   216                                                      
REMARK 465     LEU F   217                                                      
REMARK 465     GLU F   218                                                      
REMARK 465     SER F   219                                                      
REMARK 465     SER F   220                                                      
REMARK 465     ASN F   221                                                      
REMARK 465     SER F   222                                                      
REMARK 465     LYS F   223                                                      
REMARK 465     TYR F   224                                                      
REMARK 465     SER F   225                                                      
REMARK 465     LEU F   226                                                      
REMARK 465     ASN F   227                                                      
REMARK 465     THR F   228                                                      
REMARK 465     ASP F   229                                                      
REMARK 465     SER F   230                                                      
REMARK 465     SER F   231                                                      
REMARK 465     VAL F   232                                                      
REMARK 465     SER F   233                                                      
REMARK 465     TYR F   234                                                      
REMARK 465     ILE F   235                                                      
REMARK 465     ASP F   236                                                      
REMARK 465     SER F   237                                                      
REMARK 465     ALA F   238                                                      
REMARK 465     VAL F   239                                                      
REMARK 465     ILE F   240                                                      
REMARK 465     SER F   241                                                      
REMARK 465     PRO F   242                                                      
REMARK 465     ASP F   243                                                      
REMARK 465     THR F   244                                                      
REMARK 465     VAL F   245                                                      
REMARK 465     PRO F   246                                                      
REMARK 465     LEU F   247                                                      
REMARK 465     GLY F   248                                                      
REMARK 465     THR F   249                                                      
REMARK 465     GLY F   250                                                      
REMARK 465     THR F   251                                                      
REMARK 465     SER F   252                                                      
REMARK 465     ILE F   253                                                      
REMARK 465     LEU F   254                                                      
REMARK 465     SER F   255                                                      
REMARK 465     LYS F   256                                                      
REMARK 465     GLN F   257                                                      
REMARK 465     VAL F   258                                                      
REMARK 465     GLN F   259                                                      
REMARK 465     ASN F   260                                                      
REMARK 465     LYS F   261                                                      
REMARK 465     PRO F   262                                                      
REMARK 465     LYS F   263                                                      
REMARK 465     THR F   264                                                      
REMARK 465     GLY F   265                                                      
REMARK 465     ARG F   266                                                      
REMARK 465     SER F   267                                                      
REMARK 465     LEU F   268                                                      
REMARK 465     LEU F   269                                                      
REMARK 465     GLY F   270                                                      
REMARK 465     GLY F   271                                                      
REMARK 465     PRO F   272                                                      
REMARK 465     ALA F   273                                                      
REMARK 465     ALA F   274                                                      
REMARK 465     LEU F   275                                                      
REMARK 465     SER F   276                                                      
REMARK 465     PRO F   277                                                      
REMARK 465     LEU F   278                                                      
REMARK 465     THR F   279                                                      
REMARK 465     PRO F   280                                                      
REMARK 465     SER F   281                                                      
REMARK 465     PHE F   282                                                      
REMARK 465     GLY F   283                                                      
REMARK 465     ILE F   284                                                      
REMARK 465     LEU F   285                                                      
REMARK 465     PRO F   286                                                      
REMARK 465     LEU F   287                                                      
REMARK 465     GLU F   288                                                      
REMARK 465     THR F   289                                                      
REMARK 465     PRO F   290                                                      
REMARK 465     SER F   291                                                      
REMARK 465     PRO F   292                                                      
REMARK 465     GLY F   293                                                      
REMARK 465     ASP F   294                                                      
REMARK 465     GLY F   295                                                      
REMARK 465     SER F   296                                                      
REMARK 465     TYR F   297                                                      
REMARK 465     LEU F   298                                                      
REMARK 465     GLN F   299                                                      
REMARK 465     ASN F   300                                                      
REMARK 465     TYR F   301                                                      
REMARK 465     THR F   302                                                      
REMARK 465     ASN F   303                                                      
REMARK 465     THR F   304                                                      
REMARK 465     PRO F   305                                                      
REMARK 465     PRO F   306                                                      
REMARK 465     VAL F   307                                                      
REMARK 465     ILE F   308                                                      
REMARK 465     ASP F   309                                                      
REMARK 465     VAL F   310                                                      
REMARK 465     PRO F   311                                                      
REMARK 465     SER F   312                                                      
REMARK 465     THR F   313                                                      
REMARK 465     GLY F   314                                                      
REMARK 465     ALA F   315                                                      
REMARK 465     PRO F   316                                                      
REMARK 465     SER F   317                                                      
REMARK 465     LYS F   318                                                      
REMARK 465     LYS F   319                                                      
REMARK 465     SER F   320                                                      
REMARK 465     VAL F   321                                                      
REMARK 465     ALA F   322                                                      
REMARK 465     ARG F   323                                                      
REMARK 465     ILE F   324                                                      
REMARK 465     GLY F   325                                                      
REMARK 465     GLN F   326                                                      
REMARK 465     THR F   327                                                      
REMARK 465     GLY F   328                                                      
REMARK 465     THR F   329                                                      
REMARK 465     LYS F   330                                                      
REMARK 465     SER F   331                                                      
REMARK 465     VAL F   332                                                      
REMARK 465     PHE F   333                                                      
REMARK 465     SER F   334                                                      
REMARK 465     GLN F   335                                                      
REMARK 465     SER F   336                                                      
REMARK 465     GLY F   337                                                      
REMARK 465     ASN F   338                                                      
REMARK 465     SER F   339                                                      
REMARK 465     ARG F   340                                                      
REMARK 465     GLU F   341                                                      
REMARK 465     VAL F   342                                                      
REMARK 465     THR F   343                                                      
REMARK 465     PRO F   344                                                      
REMARK 465     ILE F   345                                                      
REMARK 465     LEU F   346                                                      
REMARK 465     ALA F   347                                                      
REMARK 465     GLN F   348                                                      
REMARK 465     THR F   349                                                      
REMARK 465     GLN F   350                                                      
REMARK 465     SER F   351                                                      
REMARK 465     SER F   352                                                      
REMARK 465     GLY F   353                                                      
REMARK 465     PRO F   354                                                      
REMARK 465     GLN F   355                                                      
REMARK 465     THR F   356                                                      
REMARK 465     SER F   357                                                      
REMARK 465     THR F   358                                                      
REMARK 465     THR F   359                                                      
REMARK 465     PRO F   360                                                      
REMARK 465     GLN F   361                                                      
REMARK 465     VAL F   362                                                      
REMARK 465     LEU F   363                                                      
REMARK 465     SER F   364                                                      
REMARK 465     PRO F   365                                                      
REMARK 465     THR F   366                                                      
REMARK 465     ILE F   367                                                      
REMARK 465     THR F   368                                                      
REMARK 465     SER F   369                                                      
REMARK 465     PRO F   370                                                      
REMARK 465     PRO F   371                                                      
REMARK 465     ASN F   372                                                      
REMARK 465     ALA F   373                                                      
REMARK 465     LEU F   374                                                      
REMARK 465     PRO F   375                                                      
REMARK 465     ARG F   376                                                      
REMARK 465     ARG F   377                                                      
REMARK 465     SER F   378                                                      
REMARK 465     SER F   379                                                      
REMARK 465     ARG F   380                                                      
REMARK 465     LEU F   381                                                      
REMARK 465     PHE F   382                                                      
REMARK 465     THR F   383                                                      
REMARK 465     SER F   384                                                      
REMARK 465     ASP F   385                                                      
REMARK 465     SER F   386                                                      
REMARK 465     SER F   387                                                      
REMARK 465     THR F   388                                                      
REMARK 465     THR F   389                                                      
REMARK 465     LYS F   390                                                      
REMARK 465     GLU F   391                                                      
REMARK 465     ASN F   392                                                      
REMARK 465     SER F   393                                                      
REMARK 465     LYS F   394                                                      
REMARK 465     LYS F   395                                                      
REMARK 465     LEU F   396                                                      
REMARK 465     LYS F   397                                                      
REMARK 465     MET F   398                                                      
REMARK 465     LYS F   399                                                      
REMARK 465     PHE F   400                                                      
REMARK 465     PRO F   401                                                      
REMARK 465     PRO F   402                                                      
REMARK 465     LYS F   403                                                      
REMARK 465     ILE F   404                                                      
REMARK 465     PRO F   405                                                      
REMARK 465     ASN F   406                                                      
REMARK 465     ARG F   407                                                      
REMARK 465     LYS F   408                                                      
REMARK 465     THR F   409                                                      
REMARK 465     LYS F   410                                                      
REMARK 465     SER F   411                                                      
REMARK 465     LYS F   412                                                      
REMARK 465     THR F   413                                                      
REMARK 465     ASN F   414                                                      
REMARK 465     LYS F   415                                                      
REMARK 465     GLY F   416                                                      
REMARK 465     GLY F   417                                                      
REMARK 465     ILE F   418                                                      
REMARK 465     THR F   419                                                      
REMARK 465     GLN F   420                                                      
REMARK 465     PRO F   421                                                      
REMARK 465     ASN F   422                                                      
REMARK 465     ILE F   423                                                      
REMARK 465     ASN F   424                                                      
REMARK 465     ASP F   425                                                      
REMARK 465     SER F   426                                                      
REMARK 465     LEU F   427                                                      
REMARK 465     GLU F   428                                                      
REMARK 465     ILE F   429                                                      
REMARK 465     THR F   430                                                      
REMARK 465     LYS F   431                                                      
REMARK 465     LEU F   432                                                      
REMARK 465     ASP F   433                                                      
REMARK 465     SER F   434                                                      
REMARK 465     SER F   435                                                      
REMARK 465     ILE F   436                                                      
REMARK 465     ILE F   437                                                      
REMARK 465     SER F   438                                                      
REMARK 465     GLU F   439                                                      
REMARK 465     GLY F   440                                                      
REMARK 465     LYS F   441                                                      
REMARK 465     ILE F   442                                                      
REMARK 465     SER F   443                                                      
REMARK 465     THR F   444                                                      
REMARK 465     ILE F   445                                                      
REMARK 465     THR F   446                                                      
REMARK 465     PRO F   447                                                      
REMARK 465     GLN F   448                                                      
REMARK 465     ILE F   449                                                      
REMARK 465     GLN F   450                                                      
REMARK 465     TYR F   783                                                      
REMARK 465     LEU F   784                                                      
REMARK 465     PRO F   785                                                      
REMARK 465     ASP F   786                                                      
REMARK 465     ASP F   787                                                      
REMARK 465     GLU F   788                                                      
REMARK 465     GLU F   789                                                      
REMARK 465     PRO F   790                                                      
REMARK 465     ILE F   791                                                      
REMARK 465     THR F   792                                                      
REMARK 465     GLN F   793                                                      
REMARK 465     GLU F   794                                                      
REMARK 465     GLU F   795                                                      
REMARK 465     GLN F   796                                                      
REMARK 465     ILE F   797                                                      
REMARK 465     MET F   798                                                      
REMARK 465     GLY F   799                                                      
REMARK 465     THR F   800                                                      
REMARK 465     ASP F   801                                                      
REMARK 465     GLU F   802                                                      
REMARK 465     SER F   803                                                      
REMARK 465     GLN F   804                                                      
REMARK 465     GLU F   805                                                      
REMARK 465     SER F   806                                                      
REMARK 465     SER F   807                                                      
REMARK 465     MET F   808                                                      
REMARK 465     THR F   809                                                      
REMARK 465     ASP F   810                                                      
REMARK 465     ALA F   811                                                      
REMARK 465     ASP F   812                                                      
REMARK 465     ASP F   813                                                      
REMARK 465     THR F   814                                                      
REMARK 465     GLN F   815                                                      
REMARK 465     LEU F   816                                                      
REMARK 465     HIS F   817                                                      
REMARK 465     ALA F   818                                                      
REMARK 465     ALA F   819                                                      
REMARK 465     GLU F   820                                                      
REMARK 465     SER F   821                                                      
REMARK 465     ASP F   822                                                      
REMARK 465     GLU F   823                                                      
REMARK 465     PHE F   824                                                      
REMARK 465     LEU G    26                                                      
REMARK 465     GLU G    27                                                      
REMARK 465     THR G    28                                                      
REMARK 465     ARG G    29                                                      
REMARK 465     LYS G    30                                                      
REMARK 465     LYS G    31                                                      
REMARK 465     GLN G    32                                                      
REMARK 465     LYS G    33                                                      
REMARK 465     GLU G    34                                                      
REMARK 465     ASP G    35                                                      
REMARK 465     VAL G    36                                                      
REMARK 465     GLU G    37                                                      
REMARK 465     VAL G    38                                                      
REMARK 465     VAL G    39                                                      
REMARK 465     GLY G    40                                                      
REMARK 465     GLY G    41                                                      
REMARK 465     SER G    42                                                      
REMARK 465     ASP G    43                                                      
REMARK 465     GLY G    44                                                      
REMARK 465     GLU G    45                                                      
REMARK 465     GLY G    46                                                      
REMARK 465     ALA G    47                                                      
REMARK 465     ILE G    48                                                      
REMARK 465     GLY G    49                                                      
REMARK 465     LEU G    50                                                      
REMARK 465     SER G    51                                                      
REMARK 465     SER G    52                                                      
REMARK 465     ASP G    53                                                      
REMARK 465     PRO G    54                                                      
REMARK 465     LYS G    55                                                      
REMARK 465     SER G    56                                                      
REMARK 465     ARG G    57                                                      
REMARK 465     GLU G    58                                                      
REMARK 465     GLN G    59                                                      
REMARK 465     MET G    60                                                      
REMARK 465     ILE G    61                                                      
REMARK 465     ASN G    62                                                      
REMARK 465     ASP G    63                                                      
REMARK 465     ARG G    64                                                      
REMARK 465     ILE G    65                                                      
REMARK 465     GLY G    66                                                      
REMARK 465     TYR G    67                                                      
REMARK 465     LYS G    68                                                      
REMARK 465     PRO G    69                                                      
REMARK 465     GLN G    70                                                      
REMARK 465     PRO G    71                                                      
REMARK 465     LYS G    72                                                      
REMARK 465     PRO G    73                                                      
REMARK 465     ASN G    74                                                      
REMARK 465     ASN G    75                                                      
REMARK 465     ARG G    76                                                      
REMARK 465     SER G    77                                                      
REMARK 465     SER G    78                                                      
REMARK 465     GLN G    79                                                      
REMARK 465     PHE G    80                                                      
REMARK 465     GLY G    81                                                      
REMARK 465     SER G    82                                                      
REMARK 465     LEU G    83                                                      
REMARK 465     GLU G    84                                                      
REMARK 465     PHE G    85                                                      
REMARK 465     MET H     1                                                      
REMARK 465     THR H     2                                                      
REMARK 465     VAL H     3                                                      
REMARK 465     LEU H     4                                                      
REMARK 465     THR H   171                                                      
REMARK 465     SER H   172                                                      
REMARK 465     LEU H   173                                                      
REMARK 465     GLN H   174                                                      
REMARK 465     ASN H   175                                                      
REMARK 465     PHE H   176                                                      
REMARK 465     SER H   177                                                      
REMARK 465     ASN H   178                                                      
REMARK 465     CYS H   179                                                      
REMARK 465     LEU H   180                                                      
REMARK 465     PRO H   181                                                      
REMARK 465     ASN H   182                                                      
REMARK 465     SER H   183                                                      
REMARK 465     CYS H   184                                                      
REMARK 465     THR H   185                                                      
REMARK 465     THR H   186                                                      
REMARK 465     GLN H   187                                                      
REMARK 465     VAL H   188                                                      
REMARK 465     PRO H   189                                                      
REMARK 465     ASN H   190                                                      
REMARK 465     HIS H   191                                                      
REMARK 465     SER H   192                                                      
REMARK 465     LEU H   193                                                      
REMARK 465     SER H   194                                                      
REMARK 465     HIS H   195                                                      
REMARK 465     ARG H   196                                                      
REMARK 465     GLN H   197                                                      
REMARK 465     PRO H   198                                                      
REMARK 465     GLU H   199                                                      
REMARK 465     THR H   200                                                      
REMARK 465     VAL H   201                                                      
REMARK 465     LEU H   202                                                      
REMARK 465     THR H   203                                                      
REMARK 465     GLU H   204                                                      
REMARK 465     THR H   205                                                      
REMARK 465     PRO H   206                                                      
REMARK 465     GLN H   207                                                      
REMARK 465     ASP H   208                                                      
REMARK 465     THR H   209                                                      
REMARK 465     ILE H   210                                                      
REMARK 465     GLU H   211                                                      
REMARK 465     LEU H   212                                                      
REMARK 465     ASN H   213                                                      
REMARK 465     ARG H   214                                                      
REMARK 465     LEU H   215                                                      
REMARK 465     ASN H   216                                                      
REMARK 465     LEU H   217                                                      
REMARK 465     GLU H   218                                                      
REMARK 465     SER H   219                                                      
REMARK 465     SER H   220                                                      
REMARK 465     ASN H   221                                                      
REMARK 465     SER H   222                                                      
REMARK 465     LYS H   223                                                      
REMARK 465     TYR H   224                                                      
REMARK 465     SER H   225                                                      
REMARK 465     LEU H   226                                                      
REMARK 465     ASN H   227                                                      
REMARK 465     THR H   228                                                      
REMARK 465     ASP H   229                                                      
REMARK 465     SER H   230                                                      
REMARK 465     SER H   231                                                      
REMARK 465     VAL H   232                                                      
REMARK 465     SER H   233                                                      
REMARK 465     TYR H   234                                                      
REMARK 465     ILE H   235                                                      
REMARK 465     ASP H   236                                                      
REMARK 465     SER H   237                                                      
REMARK 465     ALA H   238                                                      
REMARK 465     VAL H   239                                                      
REMARK 465     ILE H   240                                                      
REMARK 465     SER H   241                                                      
REMARK 465     PRO H   242                                                      
REMARK 465     ASP H   243                                                      
REMARK 465     THR H   244                                                      
REMARK 465     VAL H   245                                                      
REMARK 465     PRO H   246                                                      
REMARK 465     LEU H   247                                                      
REMARK 465     GLY H   248                                                      
REMARK 465     THR H   249                                                      
REMARK 465     GLY H   250                                                      
REMARK 465     THR H   251                                                      
REMARK 465     SER H   252                                                      
REMARK 465     ILE H   253                                                      
REMARK 465     LEU H   254                                                      
REMARK 465     SER H   255                                                      
REMARK 465     LYS H   256                                                      
REMARK 465     GLN H   257                                                      
REMARK 465     VAL H   258                                                      
REMARK 465     GLN H   259                                                      
REMARK 465     ASN H   260                                                      
REMARK 465     LYS H   261                                                      
REMARK 465     PRO H   262                                                      
REMARK 465     LYS H   263                                                      
REMARK 465     THR H   264                                                      
REMARK 465     GLY H   265                                                      
REMARK 465     ARG H   266                                                      
REMARK 465     SER H   267                                                      
REMARK 465     LEU H   268                                                      
REMARK 465     LEU H   269                                                      
REMARK 465     GLY H   270                                                      
REMARK 465     GLY H   271                                                      
REMARK 465     PRO H   272                                                      
REMARK 465     ALA H   273                                                      
REMARK 465     ALA H   274                                                      
REMARK 465     LEU H   275                                                      
REMARK 465     SER H   276                                                      
REMARK 465     PRO H   277                                                      
REMARK 465     LEU H   278                                                      
REMARK 465     THR H   279                                                      
REMARK 465     PRO H   280                                                      
REMARK 465     SER H   281                                                      
REMARK 465     PHE H   282                                                      
REMARK 465     GLY H   283                                                      
REMARK 465     ILE H   284                                                      
REMARK 465     LEU H   285                                                      
REMARK 465     PRO H   286                                                      
REMARK 465     LEU H   287                                                      
REMARK 465     GLU H   288                                                      
REMARK 465     THR H   289                                                      
REMARK 465     PRO H   290                                                      
REMARK 465     SER H   291                                                      
REMARK 465     PRO H   292                                                      
REMARK 465     GLY H   293                                                      
REMARK 465     ASP H   294                                                      
REMARK 465     GLY H   295                                                      
REMARK 465     SER H   296                                                      
REMARK 465     TYR H   297                                                      
REMARK 465     LEU H   298                                                      
REMARK 465     GLN H   299                                                      
REMARK 465     ASN H   300                                                      
REMARK 465     TYR H   301                                                      
REMARK 465     THR H   302                                                      
REMARK 465     ASN H   303                                                      
REMARK 465     THR H   304                                                      
REMARK 465     PRO H   305                                                      
REMARK 465     PRO H   306                                                      
REMARK 465     VAL H   307                                                      
REMARK 465     ILE H   308                                                      
REMARK 465     ASP H   309                                                      
REMARK 465     VAL H   310                                                      
REMARK 465     PRO H   311                                                      
REMARK 465     SER H   312                                                      
REMARK 465     THR H   313                                                      
REMARK 465     GLY H   314                                                      
REMARK 465     ALA H   315                                                      
REMARK 465     PRO H   316                                                      
REMARK 465     SER H   317                                                      
REMARK 465     LYS H   318                                                      
REMARK 465     LYS H   319                                                      
REMARK 465     SER H   320                                                      
REMARK 465     VAL H   321                                                      
REMARK 465     ALA H   322                                                      
REMARK 465     ARG H   323                                                      
REMARK 465     ILE H   324                                                      
REMARK 465     GLY H   325                                                      
REMARK 465     GLN H   326                                                      
REMARK 465     THR H   327                                                      
REMARK 465     GLY H   328                                                      
REMARK 465     THR H   329                                                      
REMARK 465     LYS H   330                                                      
REMARK 465     SER H   331                                                      
REMARK 465     VAL H   332                                                      
REMARK 465     PHE H   333                                                      
REMARK 465     SER H   334                                                      
REMARK 465     GLN H   335                                                      
REMARK 465     SER H   336                                                      
REMARK 465     GLY H   337                                                      
REMARK 465     ASN H   338                                                      
REMARK 465     SER H   339                                                      
REMARK 465     ARG H   340                                                      
REMARK 465     GLU H   341                                                      
REMARK 465     VAL H   342                                                      
REMARK 465     THR H   343                                                      
REMARK 465     PRO H   344                                                      
REMARK 465     ILE H   345                                                      
REMARK 465     LEU H   346                                                      
REMARK 465     ALA H   347                                                      
REMARK 465     GLN H   348                                                      
REMARK 465     THR H   349                                                      
REMARK 465     GLN H   350                                                      
REMARK 465     SER H   351                                                      
REMARK 465     SER H   352                                                      
REMARK 465     GLY H   353                                                      
REMARK 465     PRO H   354                                                      
REMARK 465     GLN H   355                                                      
REMARK 465     THR H   356                                                      
REMARK 465     SER H   357                                                      
REMARK 465     THR H   358                                                      
REMARK 465     THR H   359                                                      
REMARK 465     PRO H   360                                                      
REMARK 465     GLN H   361                                                      
REMARK 465     VAL H   362                                                      
REMARK 465     LEU H   363                                                      
REMARK 465     SER H   364                                                      
REMARK 465     PRO H   365                                                      
REMARK 465     THR H   366                                                      
REMARK 465     ILE H   367                                                      
REMARK 465     THR H   368                                                      
REMARK 465     SER H   369                                                      
REMARK 465     PRO H   370                                                      
REMARK 465     PRO H   371                                                      
REMARK 465     ASN H   372                                                      
REMARK 465     ALA H   373                                                      
REMARK 465     LEU H   374                                                      
REMARK 465     PRO H   375                                                      
REMARK 465     ARG H   376                                                      
REMARK 465     ARG H   377                                                      
REMARK 465     SER H   378                                                      
REMARK 465     SER H   379                                                      
REMARK 465     ARG H   380                                                      
REMARK 465     LEU H   381                                                      
REMARK 465     PHE H   382                                                      
REMARK 465     THR H   383                                                      
REMARK 465     SER H   384                                                      
REMARK 465     ASP H   385                                                      
REMARK 465     SER H   386                                                      
REMARK 465     SER H   387                                                      
REMARK 465     THR H   388                                                      
REMARK 465     THR H   389                                                      
REMARK 465     LYS H   390                                                      
REMARK 465     GLU H   391                                                      
REMARK 465     ASN H   392                                                      
REMARK 465     SER H   393                                                      
REMARK 465     LYS H   394                                                      
REMARK 465     LYS H   395                                                      
REMARK 465     LEU H   396                                                      
REMARK 465     LYS H   397                                                      
REMARK 465     MET H   398                                                      
REMARK 465     LYS H   399                                                      
REMARK 465     PHE H   400                                                      
REMARK 465     PRO H   401                                                      
REMARK 465     PRO H   402                                                      
REMARK 465     LYS H   403                                                      
REMARK 465     ILE H   404                                                      
REMARK 465     PRO H   405                                                      
REMARK 465     ASN H   406                                                      
REMARK 465     ARG H   407                                                      
REMARK 465     LYS H   408                                                      
REMARK 465     THR H   409                                                      
REMARK 465     LYS H   410                                                      
REMARK 465     SER H   411                                                      
REMARK 465     LYS H   412                                                      
REMARK 465     THR H   413                                                      
REMARK 465     ASN H   414                                                      
REMARK 465     LYS H   415                                                      
REMARK 465     GLY H   416                                                      
REMARK 465     GLY H   417                                                      
REMARK 465     ILE H   418                                                      
REMARK 465     THR H   419                                                      
REMARK 465     GLN H   420                                                      
REMARK 465     PRO H   421                                                      
REMARK 465     ASN H   422                                                      
REMARK 465     ILE H   423                                                      
REMARK 465     ASN H   424                                                      
REMARK 465     ASP H   425                                                      
REMARK 465     SER H   426                                                      
REMARK 465     LEU H   427                                                      
REMARK 465     GLU H   428                                                      
REMARK 465     ILE H   429                                                      
REMARK 465     THR H   430                                                      
REMARK 465     LYS H   431                                                      
REMARK 465     LEU H   432                                                      
REMARK 465     ASP H   433                                                      
REMARK 465     SER H   434                                                      
REMARK 465     SER H   435                                                      
REMARK 465     ILE H   436                                                      
REMARK 465     ILE H   437                                                      
REMARK 465     SER H   438                                                      
REMARK 465     GLU H   439                                                      
REMARK 465     GLY H   440                                                      
REMARK 465     LYS H   441                                                      
REMARK 465     ILE H   442                                                      
REMARK 465     SER H   443                                                      
REMARK 465     THR H   444                                                      
REMARK 465     ILE H   445                                                      
REMARK 465     THR H   446                                                      
REMARK 465     PRO H   447                                                      
REMARK 465     GLN H   448                                                      
REMARK 465     ILE H   449                                                      
REMARK 465     GLN H   450                                                      
REMARK 465     PRO H   768                                                      
REMARK 465     LYS H   769                                                      
REMARK 465     GLY H   770                                                      
REMARK 465     ALA H   771                                                      
REMARK 465     ASN H   772                                                      
REMARK 465     ASN H   773                                                      
REMARK 465     GLN H   774                                                      
REMARK 465     ILE H   775                                                      
REMARK 465     LYS H   776                                                      
REMARK 465     GLU H   777                                                      
REMARK 465     ALA H   778                                                      
REMARK 465     ILE H   779                                                      
REMARK 465     ASP H   780                                                      
REMARK 465     LYS H   781                                                      
REMARK 465     ARG H   782                                                      
REMARK 465     TYR H   783                                                      
REMARK 465     LEU H   784                                                      
REMARK 465     PRO H   785                                                      
REMARK 465     ASP H   786                                                      
REMARK 465     ASP H   787                                                      
REMARK 465     GLU H   788                                                      
REMARK 465     GLU H   789                                                      
REMARK 465     PRO H   790                                                      
REMARK 465     ILE H   791                                                      
REMARK 465     THR H   792                                                      
REMARK 465     GLN H   793                                                      
REMARK 465     GLU H   794                                                      
REMARK 465     GLU H   795                                                      
REMARK 465     GLN H   796                                                      
REMARK 465     ILE H   797                                                      
REMARK 465     MET H   798                                                      
REMARK 465     GLY H   799                                                      
REMARK 465     THR H   800                                                      
REMARK 465     ASP H   801                                                      
REMARK 465     GLU H   802                                                      
REMARK 465     SER H   803                                                      
REMARK 465     GLN H   804                                                      
REMARK 465     GLU H   805                                                      
REMARK 465     SER H   806                                                      
REMARK 465     SER H   807                                                      
REMARK 465     MET H   808                                                      
REMARK 465     THR H   809                                                      
REMARK 465     ASP H   810                                                      
REMARK 465     ALA H   811                                                      
REMARK 465     ASP H   812                                                      
REMARK 465     ASP H   813                                                      
REMARK 465     THR H   814                                                      
REMARK 465     GLN H   815                                                      
REMARK 465     LEU H   816                                                      
REMARK 465     HIS H   817                                                      
REMARK 465     ALA H   818                                                      
REMARK 465     ALA H   819                                                      
REMARK 465     GLU H   820                                                      
REMARK 465     SER H   821                                                      
REMARK 465     ASP H   822                                                      
REMARK 465     GLU H   823                                                      
REMARK 465     PHE H   824                                                      
REMARK 465     MET I     1                                                      
REMARK 465     LEU I     2                                                      
REMARK 465     ARG I     3                                                      
REMARK 465     PHE I     4                                                      
REMARK 465     PRO I     5                                                      
REMARK 465     ASN I   130                                                      
REMARK 465     ALA I   131                                                      
REMARK 465     ASP I   431                                                      
REMARK 465     HIS I   432                                                      
REMARK 465     VAL I   433                                                      
REMARK 465     LEU I   434                                                      
REMARK 465     PRO I   435                                                      
REMARK 465     GLU I   436                                                      
REMARK 465     LEU I   437                                                      
REMARK 465     ASN I   438                                                      
REMARK 465     GLU I   458                                                      
REMARK 465     ALA I   459                                                      
REMARK 465     PRO I   460                                                      
REMARK 465     ASP I   461                                                      
REMARK 465     LEU I   462                                                      
REMARK 465     TYR I   463                                                      
REMARK 465     ASN I   464                                                      
REMARK 465     ARG I   465                                                      
REMARK 465     LYS I   466                                                      
REMARK 465     GLY I   467                                                      
REMARK 465     LYS I   468                                                      
REMARK 465     TYR I   469                                                      
REMARK 465     SER I   758                                                      
REMARK 465     ASP I   759                                                      
REMARK 465     GLU I   760                                                      
REMARK 465     GLU I   761                                                      
REMARK 465     GLU I   762                                                      
REMARK 465     GLU I   763                                                      
REMARK 465     ALA I   764                                                      
REMARK 465     SER I   765                                                      
REMARK 465     ASN I   766                                                      
REMARK 465     LYS I   767                                                      
REMARK 465     PRO I   768                                                      
REMARK 465     VAL I   769                                                      
REMARK 465     LYS I   770                                                      
REMARK 465     ILE I   771                                                      
REMARK 465     LYS I   772                                                      
REMARK 465     GLU I   773                                                      
REMARK 465     GLU I   774                                                      
REMARK 465     VAL I   775                                                      
REMARK 465     LEU I   776                                                      
REMARK 465     SER I   777                                                      
REMARK 465     GLU I   778                                                      
REMARK 465     SER I   779                                                      
REMARK 465     GLU I   780                                                      
REMARK 465     ALA I   781                                                      
REMARK 465     GLU I   782                                                      
REMARK 465     ASN I   783                                                      
REMARK 465     GLN I   784                                                      
REMARK 465     GLN I   785                                                      
REMARK 465     ALA I   786                                                      
REMARK 465     GLY I   787                                                      
REMARK 465     ALA I   788                                                      
REMARK 465     ALA I   789                                                      
REMARK 465     ALA I   790                                                      
REMARK 465     LEU I   791                                                      
REMARK 465     ALA I   792                                                      
REMARK 465     PRO I   793                                                      
REMARK 465     GLU I   794                                                      
REMARK 465     ILE I   795                                                      
REMARK 465     VAL I   796                                                      
REMARK 465     ILE I   797                                                      
REMARK 465     LYS I   798                                                      
REMARK 465     VAL I   799                                                      
REMARK 465     GLU I   800                                                      
REMARK 465     LYS I   801                                                      
REMARK 465     LEU I   802                                                      
REMARK 465     ASP I   803                                                      
REMARK 465     PRO I   804                                                      
REMARK 465     GLU I   805                                                      
REMARK 465     LEU I   806                                                      
REMARK 465     ASP I   807                                                      
REMARK 465     SER I   808                                                      
REMARK 465     MET J     1                                                      
REMARK 465     GLU J    96                                                      
REMARK 465     GLU J    97                                                      
REMARK 465     PRO J    98                                                      
REMARK 465     ILE J    99                                                      
REMARK 465     ASN J   100                                                      
REMARK 465     LYS J   101                                                      
REMARK 465     ARG J   102                                                      
REMARK 465     LEU J   103                                                      
REMARK 465     PHE J   104                                                      
REMARK 465     GLU J   105                                                      
REMARK 465     LYS J   106                                                      
REMARK 465     TYR J   107                                                      
REMARK 465     LEU J   108                                                      
REMARK 465     LYS J   109                                                      
REMARK 465     ASP J   110                                                      
REMARK 465     GLU J   111                                                      
REMARK 465     SER J   112                                                      
REMARK 465     GLY J   113                                                      
REMARK 465     PHE J   114                                                      
REMARK 465     LYS J   115                                                      
REMARK 465     ASP J   116                                                      
REMARK 465     PRO J   117                                                      
REMARK 465     SER J   118                                                      
REMARK 465     SER J   119                                                      
REMARK 465     ASP J   120                                                      
REMARK 465     TRP J   121                                                      
REMARK 465     GLU J   122                                                      
REMARK 465     MET J   123                                                      
REMARK 465     ILE J   534                                                      
REMARK 465     GLY J   535                                                      
REMARK 465     ALA J   536                                                      
REMARK 465     ASP J   537                                                      
REMARK 465     ILE J   538                                                      
REMARK 465     LYS J   539                                                      
REMARK 465     ASP J   540                                                      
REMARK 465     LYS J   541                                                      
REMARK 465     LEU J   542                                                      
REMARK 465     LYS J   543                                                      
REMARK 465     CYS J   544                                                      
REMARK 465     TYR J   545                                                      
REMARK 465     ASP J   546                                                      
REMARK 465     PHE J   547                                                      
REMARK 465     ASP J   548                                                      
REMARK 465     VAL J   549                                                      
REMARK 465     HIS J   550                                                      
REMARK 465     THR J   551                                                      
REMARK 465     MET J   552                                                      
REMARK 465     LYS J   553                                                      
REMARK 465     THR J   554                                                      
REMARK 465     LEU J   555                                                      
REMARK 465     LYS J   556                                                      
REMARK 465     ASN J   557                                                      
REMARK 465     ILE J   558                                                      
REMARK 465     ILE J   559                                                      
REMARK 465     SER J   560                                                      
REMARK 465     PRO J   561                                                      
REMARK 465     PRO J   562                                                      
REMARK 465     TRP J   563                                                      
REMARK 465     ASP J   564                                                      
REMARK 465     PHE J   565                                                      
REMARK 465     ARG J   566                                                      
REMARK 465     GLU J   567                                                      
REMARK 465     PHE J   568                                                      
REMARK 465     GLU J   569                                                      
REMARK 465     VAL J   570                                                      
REMARK 465     GLU J   571                                                      
REMARK 465     LYS J   572                                                      
REMARK 465     GLN J   573                                                      
REMARK 465     THR J   574                                                      
REMARK 465     ALA J   575                                                      
REMARK 465     GLU J   576                                                      
REMARK 465     GLU J   577                                                      
REMARK 465     THR J   578                                                      
REMARK 465     GLY J   579                                                      
REMARK 465     LEU J   580                                                      
REMARK 465     THR J   581                                                      
REMARK 465     PRO J   582                                                      
REMARK 465     LEU J   583                                                      
REMARK 465     GLU J   584                                                      
REMARK 465     THR J   585                                                      
REMARK 465     SER J   586                                                      
REMARK 465     ARG J   587                                                      
REMARK 465     LYS J   588                                                      
REMARK 465     THR J   589                                                      
REMARK 465     PRO J   590                                                      
REMARK 465     ASP J   591                                                      
REMARK 465     SER J   592                                                      
REMARK 465     ARG J   593                                                      
REMARK 465     PRO J   594                                                      
REMARK 465     SER J   595                                                      
REMARK 465     LEU J   596                                                      
REMARK 465     GLU J   597                                                      
REMARK 465     GLU J   598                                                      
REMARK 465     THR J   599                                                      
REMARK 465     PHE J   600                                                      
REMARK 465     GLU J   601                                                      
REMARK 465     ILE J   602                                                      
REMARK 465     GLU J   603                                                      
REMARK 465     MET J   604                                                      
REMARK 465     ASN J   605                                                      
REMARK 465     GLU J   606                                                      
REMARK 465     SER J   607                                                      
REMARK 465     ASP J   608                                                      
REMARK 465     MET J   609                                                      
REMARK 465     MET J   610                                                      
REMARK 465     LEU J   611                                                      
REMARK 465     GLU J   612                                                      
REMARK 465     THR J   613                                                      
REMARK 465     SER J   614                                                      
REMARK 465     MET J   615                                                      
REMARK 465     SER J   616                                                      
REMARK 465     ASP J   617                                                      
REMARK 465     HIS J   618                                                      
REMARK 465     SER J   619                                                      
REMARK 465     THR J   620                                                      
REMARK 465     MET K     1                                                      
REMARK 465     ASP K    94                                                      
REMARK 465     MET K    95                                                      
REMARK 465     GLU K    96                                                      
REMARK 465     GLU K    97                                                      
REMARK 465     PRO K    98                                                      
REMARK 465     ILE K    99                                                      
REMARK 465     ASN K   100                                                      
REMARK 465     LYS K   101                                                      
REMARK 465     ARG K   102                                                      
REMARK 465     LEU K   103                                                      
REMARK 465     PHE K   104                                                      
REMARK 465     GLU K   105                                                      
REMARK 465     LYS K   106                                                      
REMARK 465     TYR K   107                                                      
REMARK 465     LEU K   108                                                      
REMARK 465     LYS K   109                                                      
REMARK 465     ASP K   110                                                      
REMARK 465     GLU K   111                                                      
REMARK 465     SER K   112                                                      
REMARK 465     GLY K   113                                                      
REMARK 465     PHE K   114                                                      
REMARK 465     LYS K   115                                                      
REMARK 465     ASP K   116                                                      
REMARK 465     PRO K   117                                                      
REMARK 465     SER K   118                                                      
REMARK 465     SER K   119                                                      
REMARK 465     ASP K   120                                                      
REMARK 465     TRP K   121                                                      
REMARK 465     GLU K   122                                                      
REMARK 465     MET K   123                                                      
REMARK 465     SER K   124                                                      
REMARK 465     GLN K   125                                                      
REMARK 465     SER K   126                                                      
REMARK 465     GLY K   528                                                      
REMARK 465     ASP K   529                                                      
REMARK 465     SER K   530                                                      
REMARK 465     GLU K   531                                                      
REMARK 465     ALA K   532                                                      
REMARK 465     TYR K   533                                                      
REMARK 465     ILE K   534                                                      
REMARK 465     GLY K   535                                                      
REMARK 465     ALA K   536                                                      
REMARK 465     ASP K   537                                                      
REMARK 465     ILE K   538                                                      
REMARK 465     LYS K   539                                                      
REMARK 465     ASP K   540                                                      
REMARK 465     LYS K   541                                                      
REMARK 465     LEU K   542                                                      
REMARK 465     LYS K   543                                                      
REMARK 465     CYS K   544                                                      
REMARK 465     TYR K   545                                                      
REMARK 465     ASP K   546                                                      
REMARK 465     PHE K   547                                                      
REMARK 465     ASP K   548                                                      
REMARK 465     VAL K   549                                                      
REMARK 465     HIS K   550                                                      
REMARK 465     THR K   551                                                      
REMARK 465     MET K   552                                                      
REMARK 465     LYS K   553                                                      
REMARK 465     THR K   554                                                      
REMARK 465     LEU K   555                                                      
REMARK 465     LYS K   556                                                      
REMARK 465     ASN K   557                                                      
REMARK 465     ILE K   558                                                      
REMARK 465     ILE K   559                                                      
REMARK 465     SER K   560                                                      
REMARK 465     PRO K   561                                                      
REMARK 465     PRO K   562                                                      
REMARK 465     TRP K   563                                                      
REMARK 465     ASP K   564                                                      
REMARK 465     PHE K   565                                                      
REMARK 465     ARG K   566                                                      
REMARK 465     GLU K   567                                                      
REMARK 465     PHE K   568                                                      
REMARK 465     GLU K   569                                                      
REMARK 465     VAL K   570                                                      
REMARK 465     GLU K   571                                                      
REMARK 465     LYS K   572                                                      
REMARK 465     GLN K   573                                                      
REMARK 465     THR K   574                                                      
REMARK 465     ALA K   575                                                      
REMARK 465     GLU K   576                                                      
REMARK 465     GLU K   577                                                      
REMARK 465     THR K   578                                                      
REMARK 465     GLY K   579                                                      
REMARK 465     LEU K   580                                                      
REMARK 465     THR K   581                                                      
REMARK 465     PRO K   582                                                      
REMARK 465     LEU K   583                                                      
REMARK 465     GLU K   584                                                      
REMARK 465     THR K   585                                                      
REMARK 465     SER K   586                                                      
REMARK 465     ARG K   587                                                      
REMARK 465     LYS K   588                                                      
REMARK 465     THR K   589                                                      
REMARK 465     PRO K   590                                                      
REMARK 465     ASP K   591                                                      
REMARK 465     SER K   592                                                      
REMARK 465     ARG K   593                                                      
REMARK 465     PRO K   594                                                      
REMARK 465     SER K   595                                                      
REMARK 465     LEU K   596                                                      
REMARK 465     GLU K   597                                                      
REMARK 465     GLU K   598                                                      
REMARK 465     THR K   599                                                      
REMARK 465     PHE K   600                                                      
REMARK 465     GLU K   601                                                      
REMARK 465     ILE K   602                                                      
REMARK 465     GLU K   603                                                      
REMARK 465     MET K   604                                                      
REMARK 465     ASN K   605                                                      
REMARK 465     GLU K   606                                                      
REMARK 465     SER K   607                                                      
REMARK 465     ASP K   608                                                      
REMARK 465     MET K   609                                                      
REMARK 465     MET K   610                                                      
REMARK 465     LEU K   611                                                      
REMARK 465     GLU K   612                                                      
REMARK 465     THR K   613                                                      
REMARK 465     SER K   614                                                      
REMARK 465     MET K   615                                                      
REMARK 465     SER K   616                                                      
REMARK 465     ASP K   617                                                      
REMARK 465     HIS K   618                                                      
REMARK 465     SER K   619                                                      
REMARK 465     THR K   620                                                      
REMARK 465     MET L     1                                                      
REMARK 465     THR L     2                                                      
REMARK 465     GLU M    40                                                      
REMARK 465     GLN M    41                                                      
REMARK 465     ASP M    42                                                      
REMARK 465     ASN M    43                                                      
REMARK 465     GLY M    44                                                      
REMARK 465     GLY M    45                                                      
REMARK 465     THR M    46                                                      
REMARK 465     THR M    47                                                      
REMARK 465     ASN M    68                                                      
REMARK 465     VAL M    69                                                      
REMARK 465     PRO M    70                                                      
REMARK 465     PRO M    71                                                      
REMARK 465     ILE M    72                                                      
REMARK 465     GLY M    73                                                      
REMARK 465     ASN M    74                                                      
REMARK 465     MET N     1                                                      
REMARK 465     ALA N     2                                                      
REMARK 465     ALA N     3                                                      
REMARK 465     ALA N     4                                                      
REMARK 465     VAL N     5                                                      
REMARK 465     VAL N     6                                                      
REMARK 465     VAL N     7                                                      
REMARK 465     ALA N     8                                                      
REMARK 465     GLU N     9                                                      
REMARK 465     GLY N    10                                                      
REMARK 465     ASP N    11                                                      
REMARK 465     SER N    12                                                      
REMARK 465     ASP N    13                                                      
REMARK 465     SER N    14                                                      
REMARK 465     GLY N    30                                                      
REMARK 465     LEU N    31                                                      
REMARK 465     VAL N    32                                                      
REMARK 465     PRO N    33                                                      
REMARK 465     PRO N    34                                                      
REMARK 465     ALA N    35                                                      
REMARK 465     ALA N    36                                                      
REMARK 465     LEU N    37                                                      
REMARK 465     GLY N    38                                                      
REMARK 465     LEU N    39                                                      
REMARK 465     VAL N    40                                                      
REMARK 465     SER N    41                                                      
REMARK 465     SER N    42                                                      
REMARK 465     ARG N    43                                                      
REMARK 465     THR N    44                                                      
REMARK 465     SER N    45                                                      
REMARK 465     GLY N    46                                                      
REMARK 465     ALA N    47                                                      
REMARK 465     VAL N    48                                                      
REMARK 465     PRO N    49                                                      
REMARK 465     PRO N    50                                                      
REMARK 465     LYS N    51                                                      
REMARK 465     GLU N    52                                                      
REMARK 465     GLY N    66                                                      
REMARK 465     LEU N    67                                                      
REMARK 465     HIS N    68                                                      
REMARK 465     SER N    69                                                      
REMARK 465     ASP N   103                                                      
REMARK 465     GLU N   104                                                      
REMARK 465     PRO N   105                                                      
REMARK 465     GLN N   106                                                      
REMARK 465     GLU N   192                                                      
REMARK 465     GLY N   193                                                      
REMARK 465     GLY N   194                                                      
REMARK 465     THR N   195                                                      
REMARK 465     CYS N   221                                                      
REMARK 465     ALA N   222                                                      
REMARK 465     GLY N   223                                                      
REMARK 465     CYS N   224                                                      
REMARK 465     SER N   225                                                      
REMARK 465     SER N   226                                                      
REMARK 465     ASP N   227                                                      
REMARK 465     LYS N   228                                                      
REMARK 465     GLN N   229                                                      
REMARK 465     GLN N   230                                                      
REMARK 465     CYS N   231                                                      
REMARK 465     LEU N   305                                                      
REMARK 465     GLN N   306                                                      
REMARK 465     ASP N   307                                                      
REMARK 465     GLY N   308                                                      
REMARK 465     PRO N   309                                                      
REMARK 465     ALA N   310                                                      
REMARK 465     ARG N   311                                                      
REMARK 465     PRO N   312                                                      
REMARK 465     ALA N   313                                                      
REMARK 465     SER N   314                                                      
REMARK 465     PRO N   315                                                      
REMARK 465     GLU N   316                                                      
REMARK 465     ALA N   317                                                      
REMARK 465     GLY N   318                                                      
REMARK 465     ASN N   319                                                      
REMARK 465     GLY N   444                                                      
REMARK 465     ASP N   445                                                      
REMARK 465     SER N   446                                                      
REMARK 465     ASP N   447                                                      
REMARK 465     GLY N   448                                                      
REMARK 465     THR N   449                                                      
REMARK 465     GLY N   450                                                      
REMARK 465     THR N   459                                                      
REMARK 465     ASP N   460                                                      
REMARK 465     PRO N   461                                                      
REMARK 465     ALA N   462                                                      
REMARK 465     SER N   463                                                      
REMARK 465     LEU N   464                                                      
REMARK 465     GLU N   465                                                      
REMARK 465     THR N   466                                                      
REMARK 465     GLY N   467                                                      
REMARK 465     GLN N   468                                                      
REMARK 465     ASP N   469                                                      
REMARK 465     SER N   470                                                      
REMARK 465     GLU N   471                                                      
REMARK 465     ASP N   472                                                      
REMARK 465     ASP N   473                                                      
REMARK 465     SER N   474                                                      
REMARK 465     GLY N   475                                                      
REMARK 465     ASP N   731                                                      
REMARK 465     SER N   732                                                      
REMARK 465     ASP N   733                                                      
REMARK 465     ASP N   734                                                      
REMARK 465     GLU N   735                                                      
REMARK 465     SER N   736                                                      
REMARK 465     ASP N   737                                                      
REMARK 465     SER N   738                                                      
REMARK 465     GLY N   739                                                      
REMARK 465     MET N   740                                                      
REMARK 465     ALA N   741                                                      
REMARK 465     SER N   742                                                      
REMARK 465     GLN N   743                                                      
REMARK 465     ALA N   744                                                      
REMARK 465     ASP N   745                                                      
REMARK 465     GLN N   746                                                      
REMARK 465     LYS N   747                                                      
REMARK 465     GLU N   748                                                      
REMARK 465     GLU N   749                                                      
REMARK 465     GLU N   750                                                      
REMARK 465     LEU N   751                                                      
REMARK 465     LEU N   752                                                      
REMARK 465     LEU N   753                                                      
REMARK 465     PHE N   754                                                      
REMARK 465     TRP N   755                                                      
REMARK 465     THR N   756                                                      
REMARK 465     TYR N   757                                                      
REMARK 465     ILE N   758                                                      
REMARK 465     GLN N   759                                                      
REMARK 465     ALA N   760                                                      
REMARK 465     MET N   761                                                      
REMARK 465     LEU N   762                                                      
REMARK 465     THR N   763                                                      
REMARK 465     ASN N   764                                                      
REMARK 465     LEU N   765                                                      
REMARK 465     GLU N   766                                                      
REMARK 465     SER N   767                                                      
REMARK 465     LEU N   768                                                      
REMARK 465     SER N   769                                                      
REMARK 465     LEU N   770                                                      
REMARK 465     ASP N   771                                                      
REMARK 465     ARG N   772                                                      
REMARK 465     ILE N   773                                                      
REMARK 465     TYR N   774                                                      
REMARK 465     ASN N   775                                                      
REMARK 465     MET N   776                                                      
REMARK 465     LEU N   777                                                      
REMARK 465     ARG N   778                                                      
REMARK 465     MET N   779                                                      
REMARK 465     PHE N   780                                                      
REMARK 465     VAL N   781                                                      
REMARK 465     VAL N   782                                                      
REMARK 465     THR N   783                                                      
REMARK 465     GLY N   784                                                      
REMARK 465     PRO N   785                                                      
REMARK 465     ALA N   786                                                      
REMARK 465     LEU N   787                                                      
REMARK 465     ALA N   788                                                      
REMARK 465     GLU N   789                                                      
REMARK 465     ILE N   790                                                      
REMARK 465     ASP N   791                                                      
REMARK 465     LEU N   792                                                      
REMARK 465     GLN N   793                                                      
REMARK 465     GLU N   794                                                      
REMARK 465     LEU N   795                                                      
REMARK 465     GLN N   796                                                      
REMARK 465     GLY N   797                                                      
REMARK 465     TYR N   798                                                      
REMARK 465     LEU N   799                                                      
REMARK 465     GLN N   800                                                      
REMARK 465     LYS N   801                                                      
REMARK 465     LYS N   802                                                      
REMARK 465     VAL N   803                                                      
REMARK 465     ARG N   804                                                      
REMARK 465     ASP N   805                                                      
REMARK 465     GLN N   806                                                      
REMARK 465     GLN N   807                                                      
REMARK 465     LEU N   808                                                      
REMARK 465     VAL N   809                                                      
REMARK 465     TYR N   810                                                      
REMARK 465     SER N   811                                                      
REMARK 465     ALA N   812                                                      
REMARK 465     GLY N   813                                                      
REMARK 465     VAL N   814                                                      
REMARK 465     TYR N   815                                                      
REMARK 465     ARG N   816                                                      
REMARK 465     LEU N   817                                                      
REMARK 465     PRO N   818                                                      
REMARK 465     LYS N   819                                                      
REMARK 465     ASN N   820                                                      
REMARK 465     CYS N   821                                                      
REMARK 465     SER N   822                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     SER O     3                                                      
REMARK 465     VAL O     4                                                      
REMARK 465     HIS O     5                                                      
REMARK 465     GLU O     6                                                      
REMARK 465     SER O     7                                                      
REMARK 465     LEU O     8                                                      
REMARK 465     TYR O     9                                                      
REMARK 465     PHE O    10                                                      
REMARK 465     ASN O    11                                                      
REMARK 465     PRO O    12                                                      
REMARK 465     MET O    13                                                      
REMARK 465     MET O    14                                                      
REMARK 465     THR O    15                                                      
REMARK 465     ASN O    16                                                      
REMARK 465     GLY O    17                                                      
REMARK 465     VAL O    18                                                      
REMARK 465     VAL O    19                                                      
REMARK 465     HIS O    20                                                      
REMARK 465     ALA O    21                                                      
REMARK 465     ASN O    22                                                      
REMARK 465     VAL O    23                                                      
REMARK 465     PHE O    24                                                      
REMARK 465     GLY O    25                                                      
REMARK 465     ILE O    26                                                      
REMARK 465     VAL O   170                                                      
REMARK 465     GLU O   171                                                      
REMARK 465     ASP O   172                                                      
REMARK 465     ALA O   173                                                      
REMARK 465     ASP O   174                                                      
REMARK 465     MET O   175                                                      
REMARK 465     GLU O   176                                                      
REMARK 465     LEU O   177                                                      
REMARK 465     THR O   178                                                      
REMARK 465     SER O   179                                                      
REMARK 465     ARG O   180                                                      
REMARK 465     ASP O   181                                                      
REMARK 465     GLU O   182                                                      
REMARK 465     GLY O   183                                                      
REMARK 465     GLU O   184                                                      
REMARK 465     ARG O   185                                                      
REMARK 465     LYS O   186                                                      
REMARK 465     MET O   187                                                      
REMARK 465     GLU O   188                                                      
REMARK 465     LYS O   189                                                      
REMARK 465     GLU O   190                                                      
REMARK 465     GLU O   191                                                      
REMARK 465     LEU O   192                                                      
REMARK 465     ASP O   193                                                      
REMARK 465     VAL O   194                                                      
REMARK 465     SER O   195                                                      
REMARK 465     VAL O   196                                                      
REMARK 465     ARG O   197                                                      
REMARK 465     GLU O   198                                                      
REMARK 465     GLU O   199                                                      
REMARK 465     GLU O   200                                                      
REMARK 465     VAL O   201                                                      
REMARK 465     SER O   202                                                      
REMARK 465     CYS O   203                                                      
REMARK 465     SER O   204                                                      
REMARK 465     GLY O   205                                                      
REMARK 465     ALA O   453                                                      
REMARK 465     VAL O   454                                                      
REMARK 465     ASN O   455                                                      
REMARK 465     ALA O   456                                                      
REMARK 465     GLY O   457                                                      
REMARK 465     VAL O   458                                                      
REMARK 465     HIS O   747                                                      
REMARK 465     GLY O   748                                                      
REMARK 465     MET P     1                                                      
REMARK 465     ALA P     2                                                      
REMARK 465     ALA P     3                                                      
REMARK 465     SER P     4                                                      
REMARK 465     THR P     5                                                      
REMARK 465     SER P     6                                                      
REMARK 465     MET P     7                                                      
REMARK 465     VAL P     8                                                      
REMARK 465     PRO P     9                                                      
REMARK 465     VAL P    10                                                      
REMARK 465     ALA P    11                                                      
REMARK 465     VAL P    12                                                      
REMARK 465     THR P    13                                                      
REMARK 465     ALA P    14                                                      
REMARK 465     ALA P    15                                                      
REMARK 465     VAL P    16                                                      
REMARK 465     ALA P    17                                                      
REMARK 465     PRO P    18                                                      
REMARK 465     VAL P    19                                                      
REMARK 465     LEU P    20                                                      
REMARK 465     SER P    21                                                      
REMARK 465     ILE P    22                                                      
REMARK 465     ASN P    23                                                      
REMARK 465     SER P    24                                                      
REMARK 465     ASP P    25                                                      
REMARK 465     VAL P   135                                                      
REMARK 465     ASP P   136                                                      
REMARK 465     SER P   137                                                      
REMARK 465     LEU P   138                                                      
REMARK 465     GLY P   139                                                      
REMARK 465     PRO P   140                                                      
REMARK 465     LEU P   141                                                      
REMARK 465     GLU P   142                                                      
REMARK 465     LYS P   143                                                      
REMARK 465     GLY P   144                                                      
REMARK 465     GLN P   145                                                      
REMARK 465     VAL P   146                                                      
REMARK 465     GLY P   501                                                      
REMARK 465     GLU P   502                                                      
REMARK 465     ILE P   503                                                      
REMARK 465     VAL P   504                                                      
REMARK 465     GLU P   505                                                      
REMARK 465     HIS P   506                                                      
REMARK 465     LEU P   507                                                      
REMARK 465     GLU P   508                                                      
REMARK 465     GLU P   509                                                      
REMARK 465     SER P   510                                                      
REMARK 465     PHE P   539                                                      
REMARK 465     ASN P   540                                                      
REMARK 465     ASP P   541                                                      
REMARK 465     THR P   542                                                      
REMARK 465     ARG P   543                                                      
REMARK 465     GLU P   544                                                      
REMARK 465     GLU P   545                                                      
REMARK 465     GLY P   546                                                      
REMARK 465     LYS P   547                                                      
REMARK 465     ALA P   548                                                      
REMARK 465     LEU P   549                                                      
REMARK 465     LEU P   550                                                      
REMARK 465     ARG P   551                                                      
REMARK 465     GLN P   552                                                      
REMARK 465     ILE P   553                                                      
REMARK 465     LEU P   554                                                      
REMARK 465     GLN P   555                                                      
REMARK 465     LEU P   556                                                      
REMARK 465     ARG P   557                                                      
REMARK 465     ASN P   558                                                      
REMARK 465     GLN P   559                                                      
REMARK 465     GLY P   560                                                      
REMARK 465     GLU P   561                                                      
REMARK 465     THR P   562                                                      
REMARK 465     PRO P   563                                                      
REMARK 465     THR P   564                                                      
REMARK 465     THR P   565                                                      
REMARK 465     GLU P   566                                                      
REMARK 465     VAL P   567                                                      
REMARK 465     PRO P   568                                                      
REMARK 465     ALA P   569                                                      
REMARK 465     PRO P   570                                                      
REMARK 465     PHE P   571                                                      
REMARK 465     PHE P   572                                                      
REMARK 465     LEU P   573                                                      
REMARK 465     PRO P   574                                                      
REMARK 465     ALA P   575                                                      
REMARK 465     SER P   576                                                      
REMARK 465     LEU P   577                                                      
REMARK 465     SER P   578                                                      
REMARK 465     ALA P   579                                                      
REMARK 465     ASN P   580                                                      
REMARK 465     ASN P   581                                                      
REMARK 465     THR P   582                                                      
REMARK 465     PRO P   583                                                      
REMARK 465     THR P   584                                                      
REMARK 465     ARG P   585                                                      
REMARK 465     ARG P   586                                                      
REMARK 465     VAL P   587                                                      
REMARK 465     SER P   588                                                      
REMARK 465     PRO P   589                                                      
REMARK 465     LEU P   590                                                      
REMARK 465     ASN P   591                                                      
REMARK 465     LEU P   592                                                      
REMARK 465     SER P   593                                                      
REMARK 465     SER P   594                                                      
REMARK 465     VAL P   595                                                      
REMARK 465     THR P   596                                                      
REMARK 465     PRO P   597                                                      
REMARK 465     MET R     1                                                      
REMARK 465     ALA R     2                                                      
REMARK 465     GLN R     3                                                      
REMARK 465     PHE R     4                                                      
REMARK 465     ALA R     5                                                      
REMARK 465     PHE R     6                                                      
REMARK 465     GLU R     7                                                      
REMARK 465     SER R     8                                                      
REMARK 465     ASP R     9                                                      
REMARK 465     LEU R    10                                                      
REMARK 465     HIS R    11                                                      
REMARK 465     SER R    12                                                      
REMARK 465     LEU R    13                                                      
REMARK 465     LEU R    14                                                      
REMARK 465     GLN R    15                                                      
REMARK 465     LEU R    16                                                      
REMARK 465     ASP R    17                                                      
REMARK 465     ALA R    18                                                      
REMARK 465     PRO R    19                                                      
REMARK 465     ILE R    20                                                      
REMARK 465     PRO R    21                                                      
REMARK 465     ASN R    22                                                      
REMARK 465     ALA R    23                                                      
REMARK 465     PRO R    24                                                      
REMARK 465     PRO R    25                                                      
REMARK 465     ALA R    26                                                      
REMARK 465     ARG R    27                                                      
REMARK 465     TRP R    28                                                      
REMARK 465     GLN R    29                                                      
REMARK 465     ARG R    30                                                      
REMARK 465     LYS R    31                                                      
REMARK 465     ALA R    32                                                      
REMARK 465     LYS R    33                                                      
REMARK 465     GLU R    34                                                      
REMARK 465     ALA R    35                                                      
REMARK 465     ALA R    36                                                      
REMARK 465     GLY R    37                                                      
REMARK 465     PRO R    38                                                      
REMARK 465     ALA R    39                                                      
REMARK 465     PRO R    40                                                      
REMARK 465     SER R    41                                                      
REMARK 465     PRO R    42                                                      
REMARK 465     MET R    43                                                      
REMARK 465     ARG R    44                                                      
REMARK 465     ALA R    45                                                      
REMARK 465     ALA R    46                                                      
REMARK 465     ASN R    47                                                      
REMARK 465     ARG R    48                                                      
REMARK 465     SER R    49                                                      
REMARK 465     HIS R    50                                                      
REMARK 465     SER R    51                                                      
REMARK 465     ALA R    52                                                      
REMARK 465     GLY R    53                                                      
REMARK 465     ARG R    54                                                      
REMARK 465     THR R    55                                                      
REMARK 465     PRO R    56                                                      
REMARK 465     GLY R    57                                                      
REMARK 465     ARG R    58                                                      
REMARK 465     THR R    59                                                      
REMARK 465     PRO R    60                                                      
REMARK 465     GLY R    61                                                      
REMARK 465     LYS R    62                                                      
REMARK 465     SER R    63                                                      
REMARK 465     SER R    64                                                      
REMARK 465     SER R    65                                                      
REMARK 465     LYS R    66                                                      
REMARK 465     VAL R    67                                                      
REMARK 465     GLN R    68                                                      
REMARK 465     THR R    69                                                      
REMARK 465     THR R    70                                                      
REMARK 465     PRO R    71                                                      
REMARK 465     SER R    72                                                      
REMARK 465     GLU R   102                                                      
REMARK 465     ASN R   103                                                      
REMARK 465     SER R   104                                                      
REMARK 465     GLN R   105                                                      
REMARK 465     THR R   106                                                      
REMARK 465     LYS R   136                                                      
REMARK 465     PRO R   137                                                      
REMARK 465     GLN R   138                                                      
REMARK 465     ASN R   139                                                      
REMARK 465     ALA R   140                                                      
REMARK 465     PRO R   141                                                      
REMARK 465     GLU R   142                                                      
REMARK 465     GLY R   143                                                      
REMARK 465     TYR R   144                                                      
REMARK 465     GLN R   145                                                      
REMARK 465     ASN R   146                                                      
REMARK 465     ARG R   147                                                      
REMARK 465     LEU R   148                                                      
REMARK 465     LYS R   149                                                      
REMARK 465     VAL R   150                                                      
REMARK 465     LEU R   151                                                      
REMARK 465     TYR R   152                                                      
REMARK 465     SER R   153                                                      
REMARK 465     GLN R   154                                                      
REMARK 465     LYS R   155                                                      
REMARK 465     ALA R   156                                                      
REMARK 465     THR R   157                                                      
REMARK 465     PRO R   158                                                      
REMARK 465     GLY R   159                                                      
REMARK 465     SER R   160                                                      
REMARK 465     SER R   161                                                      
REMARK 465     ARG R   162                                                      
REMARK 465     LYS R   163                                                      
REMARK 465     THR R   164                                                      
REMARK 465     CYS R   165                                                      
REMARK 465     ARG R   166                                                      
REMARK 465     TYR R   167                                                      
REMARK 465     CYS R   472                                                      
REMARK 465     PHE R   473                                                      
REMARK 465     GLU R   474                                                      
REMARK 465     LEU R   475                                                      
REMARK 465     ASP R   476                                                      
REMARK 465     PRO R   477                                                      
REMARK 465     ALA R   478                                                      
REMARK 465     ARG R   479                                                      
REMARK 465     ARG R   480                                                      
REMARK 465     ARG R   481                                                      
REMARK 465     GLU R   482                                                      
REMARK 465     ARG R   483                                                      
REMARK 465     GLU R   484                                                      
REMARK 465     LYS R   485                                                      
REMARK 465     ALA R   486                                                      
REMARK 465     SER R   487                                                      
REMARK 465     ALA R   488                                                      
REMARK 465     ALA R   489                                                      
REMARK 465     LYS R   490                                                      
REMARK 465     SER R   491                                                      
REMARK 465     GLN S   667                                                      
REMARK 465     ASN S   668                                                      
REMARK 465     SER S   669                                                      
REMARK 465     ALA S   670                                                      
REMARK 465     SER S   671                                                      
REMARK 465     LYS S   672                                                      
REMARK 465     ARG S   673                                                      
REMARK 465     SER S   674                                                      
REMARK 465     LEU S   675                                                      
REMARK 465     TYR S   676                                                      
REMARK 465     SER S   677                                                      
REMARK 465     LEU S   678                                                      
REMARK 465     GLN S   679                                                      
REMARK 465     SER S   680                                                      
REMARK 465     ILE S   681                                                      
REMARK 465     SER S   682                                                      
REMARK 465     LYS S   683                                                      
REMARK 465     ARG S   684                                                      
REMARK 465     SER S   685                                                      
REMARK 465     LEU S   686                                                      
REMARK 465     ASN S   687                                                      
REMARK 465     LEU S   688                                                      
REMARK 465     ASN S   689                                                      
REMARK 465     ASP S   690                                                      
REMARK 465     LEU S   691                                                      
REMARK 465     LEU S   692                                                      
REMARK 465     VAL S   693                                                      
REMARK 465     PHE S   694                                                      
REMARK 465     ASP S   695                                                      
REMARK 465     ASP S   696                                                      
REMARK 465     PRO S   697                                                      
REMARK 465     LEU S   698                                                      
REMARK 465     PRO S   699                                                      
REMARK 465     SER S   700                                                      
REMARK 465     LYS S   701                                                      
REMARK 465     LYS S   702                                                      
REMARK 465     PRO S   703                                                      
REMARK 465     ALA S   704                                                      
REMARK 465     SER S   705                                                      
REMARK 465     GLU S   706                                                      
REMARK 465     ASN S   707                                                      
REMARK 465     VAL S   708                                                      
REMARK 465     ASN S   709                                                      
REMARK 465     LYS S   710                                                      
REMARK 465     SER S   711                                                      
REMARK 465     GLU S   712                                                      
REMARK 465     PRO S   713                                                      
REMARK 465     HIS S   714                                                      
REMARK 465     SER S   715                                                      
REMARK 465     LEU S   716                                                      
REMARK 465     GLU S   717                                                      
REMARK 465     SER S   718                                                      
REMARK 465     ASP S   719                                                      
REMARK 465     SER S   720                                                      
REMARK 465     ASP S   721                                                      
REMARK 465     PHE S   722                                                      
REMARK 465     GLU S   723                                                      
REMARK 465     ILE S   724                                                      
REMARK 465     LEU S   725                                                      
REMARK 465     CYS S   726                                                      
REMARK 465     ASP S   727                                                      
REMARK 465     GLN S   728                                                      
REMARK 465     ILE S   729                                                      
REMARK 465     LEU S   730                                                      
REMARK 465     PHE S   731                                                      
REMARK 465     GLY S   732                                                      
REMARK 465     ASN S   733                                                      
REMARK 465     ALA S   734                                                      
REMARK 465     LEU S   735                                                      
REMARK 465     ASP S   736                                                      
REMARK 465     ARG S   737                                                      
REMARK 465     ILE S   738                                                      
REMARK 465     LEU S   739                                                      
REMARK 465     GLU S   740                                                      
REMARK 465     GLU S   741                                                      
REMARK 465     GLU S   742                                                      
REMARK 465     GLU S   743                                                      
REMARK 465     ASP S   744                                                      
REMARK 465     ASN S   745                                                      
REMARK 465     GLU S   746                                                      
REMARK 465     LYS S   747                                                      
REMARK 465     GLU S   748                                                      
REMARK 465     ARG S   749                                                      
REMARK 465     ASP S   750                                                      
REMARK 465     THR S   751                                                      
REMARK 465     GLN S   752                                                      
REMARK 465     ARG S   753                                                      
REMARK 465     GLN S   754                                                      
REMARK 465     ARG S   755                                                      
REMARK 465     GLN S   756                                                      
REMARK 465     ASN S   757                                                      
REMARK 465     ASP S   758                                                      
REMARK 465     THR S   759                                                      
REMARK 465     LYS S   760                                                      
REMARK 465     SER S   761                                                      
REMARK 465     SER S   762                                                      
REMARK 465     ALA S   763                                                      
REMARK 465     ASP S   764                                                      
REMARK 465     THR S   765                                                      
REMARK 465     PHE S   766                                                      
REMARK 465     THR S   767                                                      
REMARK 465     ILE S   768                                                      
REMARK 465     SER S   769                                                      
REMARK 465     GLY S   770                                                      
REMARK 465     VAL S   771                                                      
REMARK 465     SER S   772                                                      
REMARK 465     THR S   773                                                      
REMARK 465     ASN S   774                                                      
REMARK 465     LYS S   775                                                      
REMARK 465     GLU S   776                                                      
REMARK 465     ASN S   777                                                      
REMARK 465     GLU S   778                                                      
REMARK 465     GLY S   779                                                      
REMARK 465     PRO S   780                                                      
REMARK 465     GLU S   781                                                      
REMARK 465     TYR S   782                                                      
REMARK 465     PRO S   783                                                      
REMARK 465     THR S   784                                                      
REMARK 465     LYS S   785                                                      
REMARK 465     ILE S   786                                                      
REMARK 465     GLU S   787                                                      
REMARK 465     LYS S   788                                                      
REMARK 465     ASN S   789                                                      
REMARK 465     GLN S   790                                                      
REMARK 465     PHE S   791                                                      
REMARK 465     ASN S   792                                                      
REMARK 465     MET S   793                                                      
REMARK 465     SER S   794                                                      
REMARK 465     TYR S   795                                                      
REMARK 465     LYS S   796                                                      
REMARK 465     PRO S   797                                                      
REMARK 465     SER S   798                                                      
REMARK 465     GLU S   799                                                      
REMARK 465     ASN S   800                                                      
REMARK 465     MET S   801                                                      
REMARK 465     SER S   802                                                      
REMARK 465     GLY S   803                                                      
REMARK 465     LEU S   804                                                      
REMARK 465     SER S   805                                                      
REMARK 465     SER S   806                                                      
REMARK 465     PHE S   807                                                      
REMARK 465     PRO S   808                                                      
REMARK 465     ILE S   809                                                      
REMARK 465     PHE S   810                                                      
REMARK 465     GLU S   811                                                      
REMARK 465     LYS S   812                                                      
REMARK 465     GLU S   813                                                      
REMARK 465     ASN S   814                                                      
REMARK 465     THR S   815                                                      
REMARK 465     LEU S   816                                                      
REMARK 465     SER S   817                                                      
REMARK 465     SER S   818                                                      
REMARK 465     SER S   819                                                      
REMARK 465     TYR S   820                                                      
REMARK 465     LEU S   821                                                      
REMARK 465     GLU S   822                                                      
REMARK 465     GLU S   823                                                      
REMARK 465     GLN S   824                                                      
REMARK 465     LYS S   825                                                      
REMARK 465     PRO S   826                                                      
REMARK 465     LYS S   827                                                      
REMARK 465     PHE S   838                                                      
REMARK 465     ASN S   839                                                      
REMARK 465     LYS S   840                                                      
REMARK 465     MET S   841                                                      
REMARK 465     ASN S   842                                                      
REMARK 465     LYS S   843                                                      
REMARK 465     GLN S   844                                                      
REMARK 465     GLU S   845                                                      
REMARK 465     GLY S   846                                                      
REMARK 465     MET S   847                                                      
REMARK 465     ARG S   848                                                      
REMARK 465     ILE S   849                                                      
REMARK 465     GLU S   850                                                      
REMARK 465     LYS S   851                                                      
REMARK 465     LYS S   852                                                      
REMARK 465     ILE S   853                                                      
REMARK 465     GLN S   854                                                      
REMARK 465     ARG S   855                                                      
REMARK 465     GLU S   856                                                      
REMARK 465     GLN S   857                                                      
REMARK 465     LEU S   858                                                      
REMARK 465     GLN S   859                                                      
REMARK 465     LYS S   860                                                      
REMARK 465     LYS S   861                                                      
REMARK 465     ASN S   862                                                      
REMARK 465     ASP S   863                                                      
REMARK 465     ARG S   864                                                      
REMARK 465     PRO S   865                                                      
REMARK 465     SER S   866                                                      
REMARK 465     PRO S   867                                                      
REMARK 465     LEU S   868                                                      
REMARK 465     LYS S   869                                                      
REMARK 465     PRO S   870                                                      
REMARK 465     ILE S   871                                                      
REMARK 465     GLN S   872                                                      
REMARK 465     LEU W    26                                                      
REMARK 465     GLU W    27                                                      
REMARK 465     THR W    28                                                      
REMARK 465     ARG W    29                                                      
REMARK 465     LYS W    30                                                      
REMARK 465     LYS W    31                                                      
REMARK 465     GLN W    32                                                      
REMARK 465     LYS W    33                                                      
REMARK 465     GLU W    34                                                      
REMARK 465     ASP W    35                                                      
REMARK 465     VAL W    36                                                      
REMARK 465     GLU W    37                                                      
REMARK 465     VAL W    38                                                      
REMARK 465     VAL W    39                                                      
REMARK 465     GLY W    40                                                      
REMARK 465     GLY W    41                                                      
REMARK 465     SER W    42                                                      
REMARK 465     ASP W    43                                                      
REMARK 465     GLY W    44                                                      
REMARK 465     GLU W    45                                                      
REMARK 465     GLY W    46                                                      
REMARK 465     ALA W    47                                                      
REMARK 465     ILE W    48                                                      
REMARK 465     GLY W    49                                                      
REMARK 465     LEU W    50                                                      
REMARK 465     SER W    51                                                      
REMARK 465     SER W    52                                                      
REMARK 465     ASP W    53                                                      
REMARK 465     PRO W    54                                                      
REMARK 465     LYS W    55                                                      
REMARK 465     SER W    56                                                      
REMARK 465     ARG W    57                                                      
REMARK 465     GLU W    58                                                      
REMARK 465     GLN W    59                                                      
REMARK 465     MET W    60                                                      
REMARK 465     ILE W    61                                                      
REMARK 465     ASN W    62                                                      
REMARK 465     ASP W    63                                                      
REMARK 465     ARG W    64                                                      
REMARK 465     ILE W    65                                                      
REMARK 465     GLY W    66                                                      
REMARK 465     TYR W    67                                                      
REMARK 465     LYS W    68                                                      
REMARK 465     PRO W    69                                                      
REMARK 465     GLN W    70                                                      
REMARK 465     PRO W    71                                                      
REMARK 465     LYS W    72                                                      
REMARK 465     PRO W    73                                                      
REMARK 465     ASN W    74                                                      
REMARK 465     ASN W    75                                                      
REMARK 465     ARG W    76                                                      
REMARK 465     SER W    77                                                      
REMARK 465     SER W    78                                                      
REMARK 465     GLN W    79                                                      
REMARK 465     PHE W    80                                                      
REMARK 465     GLY W    81                                                      
REMARK 465     SER W    82                                                      
REMARK 465     LEU W    83                                                      
REMARK 465     GLU W    84                                                      
REMARK 465     PHE W    85                                                      
REMARK 465     MET X     1                                                      
REMARK 465     ASP X     2                                                      
REMARK 465     PRO X     3                                                      
REMARK 465     GLY X     4                                                      
REMARK 465     ASP X     5                                                      
REMARK 465     ALA X     6                                                      
REMARK 465     ALA X     7                                                      
REMARK 465     ILE X     8                                                      
REMARK 465     LEU X     9                                                      
REMARK 465     GLU X    10                                                      
REMARK 465     SER X    11                                                      
REMARK 465     SER X    12                                                      
REMARK 465     LEU X    13                                                      
REMARK 465     ARG X    14                                                      
REMARK 465     ILE X    15                                                      
REMARK 465     LEU X    16                                                      
REMARK 465     TYR X    17                                                      
REMARK 465     ARG X    18                                                      
REMARK 465     LEU X    19                                                      
REMARK 465     PHE X    20                                                      
REMARK 465     GLU X    21                                                      
REMARK 465     SER X    22                                                      
REMARK 465     VAL X    23                                                      
REMARK 465     LEU X    24                                                      
REMARK 465     PRO X    25                                                      
REMARK 465     PRO X    26                                                      
REMARK 465     LEU X    27                                                      
REMARK 465     PRO X    28                                                      
REMARK 465     ALA X    29                                                      
REMARK 465     ALA X    30                                                      
REMARK 465     LEU X    31                                                      
REMARK 465     GLN X    32                                                      
REMARK 465     SER X    33                                                      
REMARK 465     ARG X    34                                                      
REMARK 465     MET X    35                                                      
REMARK 465     SER X   111                                                      
REMARK 465     LYS X   112                                                      
REMARK 465     THR X   113                                                      
REMARK 465     SER X   114                                                      
REMARK 465     LYS X   115                                                      
REMARK 465     VAL X   116                                                      
REMARK 465     ARG X   117                                                      
REMARK 465     PRO X   118                                                      
REMARK 465     SER X   119                                                      
REMARK 465     THR X   120                                                      
REMARK 465     GLY X   121                                                      
REMARK 465     ASN X   122                                                      
REMARK 465     SER X   123                                                      
REMARK 465     ALA X   124                                                      
REMARK 465     SER X   125                                                      
REMARK 465     THR X   126                                                      
REMARK 465     PRO X   127                                                      
REMARK 465     GLN X   128                                                      
REMARK 465     SER X   129                                                      
REMARK 465     GLN X   130                                                      
REMARK 465     CYS X   131                                                      
REMARK 465     ASN X   541                                                      
REMARK 465     ASP X   542                                                      
REMARK 465     GLN X   543                                                      
REMARK 465     LYS X   544                                                      
REMARK 465     SER X   545                                                      
REMARK 465     LEU X   546                                                      
REMARK 465     GLU X   547                                                      
REMARK 465     GLY X   548                                                      
REMARK 465     MET X   549                                                      
REMARK 465     GLN X   550                                                      
REMARK 465     LYS X   551                                                      
REMARK 465     MET X   552                                                      
REMARK 465     GLU X   553                                                      
REMARK 465     LYS X   554                                                      
REMARK 465     GLU X   555                                                      
REMARK 465     GLU X   556                                                      
REMARK 465     SER X   557                                                      
REMARK 465     PRO X   558                                                      
REMARK 465     THR X   559                                                      
REMARK 465     ASP X   560                                                      
REMARK 465     ALA X   561                                                      
REMARK 465     THR X   562                                                      
REMARK 465     GLN X   563                                                      
REMARK 465     GLU X   564                                                      
REMARK 465     GLU X   565                                                      
REMARK 465     ASP X   566                                                      
REMARK 465     VAL X   567                                                      
REMARK 465     ASP X   568                                                      
REMARK 465     ASP X   569                                                      
REMARK 465     MET X   570                                                      
REMARK 465     GLU X   571                                                      
REMARK 465     GLY X   572                                                      
REMARK 465     SER X   573                                                      
REMARK 465     GLY X   574                                                      
REMARK 465     GLU X   575                                                      
REMARK 465     GLU X   576                                                      
REMARK 465     GLY X   577                                                      
REMARK 465     ASP X   578                                                      
REMARK 465     LEU X   579                                                      
REMARK 465     GLU X   580                                                      
REMARK 465     GLY X   581                                                      
REMARK 465     SER X   582                                                      
REMARK 465     ASP X   583                                                      
REMARK 465     SER X   584                                                      
REMARK 465     GLU X   585                                                      
REMARK 465     ALA X   586                                                      
REMARK 465     ALA X   587                                                      
REMARK 465     GLN X   588                                                      
REMARK 465     TRP X   589                                                      
REMARK 465     ALA X   590                                                      
REMARK 465     ASP X   591                                                      
REMARK 465     GLN X   592                                                      
REMARK 465     GLU X   593                                                      
REMARK 465     GLN X   594                                                      
REMARK 465     TRP X   595                                                      
REMARK 465     PHE X   596                                                      
REMARK 465     GLY X   597                                                      
REMARK 465     MET X   598                                                      
REMARK 465     GLN X   599                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     ASP Y     2                                                      
REMARK 465     PRO Y     3                                                      
REMARK 465     GLY Y     4                                                      
REMARK 465     ASP Y     5                                                      
REMARK 465     ALA Y     6                                                      
REMARK 465     ALA Y     7                                                      
REMARK 465     ILE Y     8                                                      
REMARK 465     LEU Y     9                                                      
REMARK 465     GLU Y    10                                                      
REMARK 465     SER Y    11                                                      
REMARK 465     SER Y    12                                                      
REMARK 465     LEU Y    13                                                      
REMARK 465     ARG Y    14                                                      
REMARK 465     ILE Y    15                                                      
REMARK 465     LEU Y    16                                                      
REMARK 465     TYR Y    17                                                      
REMARK 465     ARG Y    18                                                      
REMARK 465     LEU Y    19                                                      
REMARK 465     PHE Y    20                                                      
REMARK 465     GLU Y    21                                                      
REMARK 465     SER Y    22                                                      
REMARK 465     VAL Y    23                                                      
REMARK 465     LEU Y    24                                                      
REMARK 465     PRO Y    25                                                      
REMARK 465     PRO Y    26                                                      
REMARK 465     LEU Y    27                                                      
REMARK 465     PRO Y    28                                                      
REMARK 465     ALA Y    29                                                      
REMARK 465     ALA Y    30                                                      
REMARK 465     LEU Y    31                                                      
REMARK 465     GLN Y    32                                                      
REMARK 465     SER Y    33                                                      
REMARK 465     ARG Y    34                                                      
REMARK 465     MET Y    35                                                      
REMARK 465     SER Y   111                                                      
REMARK 465     LYS Y   112                                                      
REMARK 465     THR Y   113                                                      
REMARK 465     SER Y   114                                                      
REMARK 465     LYS Y   115                                                      
REMARK 465     VAL Y   116                                                      
REMARK 465     ARG Y   117                                                      
REMARK 465     PRO Y   118                                                      
REMARK 465     SER Y   119                                                      
REMARK 465     THR Y   120                                                      
REMARK 465     GLY Y   121                                                      
REMARK 465     ASN Y   122                                                      
REMARK 465     SER Y   123                                                      
REMARK 465     ALA Y   124                                                      
REMARK 465     SER Y   125                                                      
REMARK 465     THR Y   126                                                      
REMARK 465     PRO Y   127                                                      
REMARK 465     GLN Y   128                                                      
REMARK 465     SER Y   129                                                      
REMARK 465     GLN Y   130                                                      
REMARK 465     CYS Y   131                                                      
REMARK 465     GLU Y   553                                                      
REMARK 465     LYS Y   554                                                      
REMARK 465     GLU Y   555                                                      
REMARK 465     GLU Y   556                                                      
REMARK 465     SER Y   557                                                      
REMARK 465     PRO Y   558                                                      
REMARK 465     THR Y   559                                                      
REMARK 465     ASP Y   560                                                      
REMARK 465     ALA Y   561                                                      
REMARK 465     THR Y   562                                                      
REMARK 465     GLN Y   563                                                      
REMARK 465     GLU Y   564                                                      
REMARK 465     GLU Y   565                                                      
REMARK 465     ASP Y   566                                                      
REMARK 465     VAL Y   567                                                      
REMARK 465     ASP Y   568                                                      
REMARK 465     ASP Y   569                                                      
REMARK 465     MET Y   570                                                      
REMARK 465     GLU Y   571                                                      
REMARK 465     GLY Y   572                                                      
REMARK 465     SER Y   573                                                      
REMARK 465     GLY Y   574                                                      
REMARK 465     GLU Y   575                                                      
REMARK 465     GLU Y   576                                                      
REMARK 465     GLY Y   577                                                      
REMARK 465     ASP Y   578                                                      
REMARK 465     LEU Y   579                                                      
REMARK 465     GLU Y   580                                                      
REMARK 465     GLY Y   581                                                      
REMARK 465     SER Y   582                                                      
REMARK 465     ASP Y   583                                                      
REMARK 465     SER Y   584                                                      
REMARK 465     GLU Y   585                                                      
REMARK 465     ALA Y   586                                                      
REMARK 465     ALA Y   587                                                      
REMARK 465     GLN Y   588                                                      
REMARK 465     TRP Y   589                                                      
REMARK 465     ALA Y   590                                                      
REMARK 465     ASP Y   591                                                      
REMARK 465     GLN Y   592                                                      
REMARK 465     GLU Y   593                                                      
REMARK 465     GLN Y   594                                                      
REMARK 465     TRP Y   595                                                      
REMARK 465     PHE Y   596                                                      
REMARK 465     GLY Y   597                                                      
REMARK 465     MET Y   598                                                      
REMARK 465     GLN Y   599                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     TRP A  49    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP A  49    CZ3  CH2                                            
REMARK 470     SER A  50    OG                                                  
REMARK 470     SER A  51    OG                                                  
REMARK 470     ASP A  52    CG   OD1  OD2                                       
REMARK 470     LEU A  57    CG   CD1  CD2                                       
REMARK 470     VAL A  58    CG1  CG2                                            
REMARK 470     LYS A  71    CG   CD   CE   NZ                                   
REMARK 470     GLU A  82    CG   CD   OE1  OE2                                  
REMARK 470     ILE A  83    CG1  CG2  CD1                                       
REMARK 470     GLN A 109    CG   CD   OE1  NE2                                  
REMARK 470     GLU A 146    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 148    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 184    CG   CD   CE   NZ                                   
REMARK 470     PRO A 206    CG   CD                                             
REMARK 470     GLU A 219    CG   CD   OE1  OE2                                  
REMARK 470     VAL A 236    CG1  CG2                                            
REMARK 470     ASP A 241    CG   OD1  OD2                                       
REMARK 470     ASN A 264    CG   OD1  ND2                                       
REMARK 470     LYS A 275    CG   CD   CE   NZ                                   
REMARK 470     SER A 276    OG                                                  
REMARK 470     GLU A 277    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 278    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 279    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 280    CG   OD1  ND2                                       
REMARK 470     VAL A 281    CG1  CG2                                            
REMARK 470     CYS A 408    SG                                                  
REMARK 470     THR A 414    OG1  CG2                                            
REMARK 470     GLU A 415    CG   CD   OE1  OE2                                  
REMARK 470     SER A 425    OG                                                  
REMARK 470     GLU A 447    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 465    CG   CD   OE1  NE2                                  
REMARK 470     LYS A 484    CG   CD   CE   NZ                                   
REMARK 470     ASP A 486    CG   OD1  OD2                                       
REMARK 470     GLU A 492    CG   CD   OE1  OE2                                  
REMARK 470     SER A 494    OG                                                  
REMARK 470     LYS A 631    CG   CD   CE   NZ                                   
REMARK 470     GLU A 632    CG   CD   OE1  OE2                                  
REMARK 470     PRO A 651    CG   CD                                             
REMARK 470     GLU A 656    CG   CD   OE1  OE2                                  
REMARK 470     TYR A 670    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN A 671    CG   OD1  ND2                                       
REMARK 470     THR A 672    OG1  CG2                                            
REMARK 470     ASP A 673    CG   OD1  OD2                                       
REMARK 470     SER A 752    OG                                                  
REMARK 470     THR A 753    OG1  CG2                                            
REMARK 470     LEU A 754    CG   CD1  CD2                                       
REMARK 470     LEU A 755    CG   CD1  CD2                                       
REMARK 470     PHE A 756    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     VAL A 814    CG1  CG2                                            
REMARK 470     PHE A 837    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR A 838    OG1  CG2                                            
REMARK 470     SER A 839    OG                                                  
REMARK 470     GLU A 840    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 855    CG   CD   OE1  OE2                                  
REMARK 470     MET A 857    CG   SD   CE                                        
REMARK 470     LYS A 985    CG   CD   CE   NZ                                   
REMARK 470     GLN A 986    CG   CD   OE1  NE2                                  
REMARK 470     TYR A1054    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU A1056    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1098    CG   CD   OE1  OE2                                  
REMARK 470     ASP A1126    CG   OD1  OD2                                       
REMARK 470     MET A1285    CG   SD   CE                                        
REMARK 470     GLU A1286    CG   CD   OE1  OE2                                  
REMARK 470     CYS A1288    SG                                                  
REMARK 470     ASP A1318    CG   OD1  OD2                                       
REMARK 470     ASP A1356    CG   OD1  OD2                                       
REMARK 470     THR A1357    OG1  CG2                                            
REMARK 470     MET A1393    CG   SD   CE                                        
REMARK 470     GLU A1402    CG   CD   OE1  OE2                                  
REMARK 470     ASP A1418    CG   OD1  OD2                                       
REMARK 470     ASN A1422    CG   OD1  ND2                                       
REMARK 470     ARG A1435    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A1436    CG   CD   OE1  OE2                                  
REMARK 470     ASN A1437    CG   OD1  ND2                                       
REMARK 470     LEU A1452    CG   CD1  CD2                                       
REMARK 470     GLU A1549    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1659    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1680    CG   CD1  CD2                                       
REMARK 470     LYS A1709    CG   CD   CE   NZ                                   
REMARK 470     ASN A1727    CG   OD1  ND2                                       
REMARK 470     ASN A1760    CG   OD1  ND2                                       
REMARK 470     LYS A1764    CG   CD   CE   NZ                                   
REMARK 470     ARG A1803    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS A1826    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLN A1827    CG   CD   OE1  NE2                                  
REMARK 470     GLU A1843    CG   CD   OE1  OE2                                  
REMARK 470     VAL A1862    CG1  CG2                                            
REMARK 470     GLU A1879    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1889    CG   CD1  CD2                                       
REMARK 470     THR A1910    OG1  CG2                                            
REMARK 470     SER A1911    OG                                                  
REMARK 470     PHE A1912    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU A1914    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1915    CG   CD1  CD2                                       
REMARK 470     LEU A1916    CG   CD1  CD2                                       
REMARK 470     PHE A1917    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS A1918    CG   CD   CE   NZ                                   
REMARK 470     PHE A1919    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS A1920    CG   CD   CE   NZ                                   
REMARK 470     GLN A1921    CG   CD   OE1  NE2                                  
REMARK 470     LEU A1922    CG   CD1  CD2                                       
REMARK 470     LYS A1923    CG   CD   CE   NZ                                   
REMARK 470     MET A1924    CG   SD   CE                                        
REMARK 470     PRO A1925    CG   CD                                             
REMARK 470     VAL A1926    CG1  CG2                                            
REMARK 470     ARG A1927    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A1929    CG   CD1  CD2                                       
REMARK 470     LEU A1930    CG   CD1  CD2                                       
REMARK 470     ARG A1931    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A1932    CG   CD1  CD2                                       
REMARK 470     PRO A1934    CG   CD                                             
REMARK 470     ASN B  19    CG   OD1  ND2                                       
REMARK 470     ASP B  20    CG   OD1  OD2                                       
REMARK 470     GLU B  21    CG   CD   OE1  OE2                                  
REMARK 470     ASN B  22    CG   OD1  ND2                                       
REMARK 470     LYS B  38    CG   CD   CE   NZ                                   
REMARK 470     VAL B  39    CG1  CG2                                            
REMARK 470     PRO B  40    CG   CD                                             
REMARK 470     ASP B  42    CG   OD1  OD2                                       
REMARK 470     GLN B  67    CG   CD   OE1  NE2                                  
REMARK 470     GLN B  68    CG   CD   OE1  NE2                                  
REMARK 470     GLN B  70    CG   CD   OE1  NE2                                  
REMARK 470     GLU C  69    CG   CD   OE1  OE2                                  
REMARK 470     CYS C 109    SG                                                  
REMARK 470     LYS C 281    CG   CD   CE   NZ                                   
REMARK 470     ASP C 496    CG   OD1  OD2                                       
REMARK 470     SER C 499    OG                                                  
REMARK 470     CYS C 500    SG                                                  
REMARK 470     ASP D  21    CG   OD1  OD2                                       
REMARK 470     ARG D  22    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO D  23    CG   CD                                             
REMARK 470     CYS D  24    SG                                                  
REMARK 470     LEU D  51    CG   CD1  CD2                                       
REMARK 470     LYS D  56    CG   CD   CE   NZ                                   
REMARK 470     ARG E  52    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU E  54    CG   CD1  CD2                                       
REMARK 470     CYS E  55    SG                                                  
REMARK 470     GLN F   5    CG   CD   OE1  NE2                                  
REMARK 470     PHE F 168    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS F 169    CG   CD   CE   NZ                                   
REMARK 470     PHE F 170    CB   CG   CD1  CD2  CE1  CE2  CZ                    
REMARK 470     PHE F 452    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN F 453    CG   OD1  ND2                                       
REMARK 470     LEU F 454    CG   CD1  CD2                                       
REMARK 470     LYS F 456    CG   CD   CE   NZ                                   
REMARK 470     ASP F 767    CG   OD1  OD2                                       
REMARK 470     PRO F 768    CG   CD                                             
REMARK 470     LYS F 769    CG   CD   CE   NZ                                   
REMARK 470     ASN F 772    CG   OD1  ND2                                       
REMARK 470     ASN F 773    CG   OD1  ND2                                       
REMARK 470     GLN F 774    CG   CD   OE1  NE2                                  
REMARK 470     ILE F 775    CG1  CG2  CD1                                       
REMARK 470     LYS F 776    CG   CD   CE   NZ                                   
REMARK 470     GLU F 777    CG   CD   OE1  OE2                                  
REMARK 470     ILE F 779    CG1  CG2  CD1                                       
REMARK 470     ASP F 780    CG   OD1  OD2                                       
REMARK 470     LYS F 781    CG   CD   CE   NZ                                   
REMARK 470     ARG F 782    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G  24    CG   CD   CE   NZ                                   
REMARK 470     ASP G  25    CG   OD1  OD2                                       
REMARK 470     GLN H   5    CG   CD   OE1  NE2                                  
REMARK 470     PHE H 168    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS H 169    CG   CD   CE   NZ                                   
REMARK 470     PHE H 170    CB   CG   CD1  CD2  CE1  CE2  CZ                    
REMARK 470     PHE H 452    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN H 453    CG   OD1  ND2                                       
REMARK 470     LEU H 454    CG   CD1  CD2                                       
REMARK 470     ASP H 767    CG   OD1  OD2                                       
REMARK 470     PHE I 128    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TYR I 129    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU I 132    CD   OE1  OE2                                       
REMARK 470     ASP I 133    CG   OD1  OD2                                       
REMARK 470     ASN I 136    CG   OD1  ND2                                       
REMARK 470     LYS I 147    CG   CD   CE   NZ                                   
REMARK 470     ASN I 148    CG   OD1  ND2                                       
REMARK 470     TYR I 149    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN I 151    CG   OD1  ND2                                       
REMARK 470     THR I 152    OG1  CG2                                            
REMARK 470     LYS I 154    CG   CD   CE   NZ                                   
REMARK 470     GLU I 159    CG   CD   OE1  OE2                                  
REMARK 470     ASN I 160    CG   OD1  ND2                                       
REMARK 470     GLN I 292    CG   CD   OE1  NE2                                  
REMARK 470     GLU I 293    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 294    CG   CD   CE   NZ                                   
REMARK 470     ASN I 295    CG   OD1  ND2                                       
REMARK 470     THR I 296    OG1  CG2                                            
REMARK 470     THR I 297    OG1  CG2                                            
REMARK 470     THR I 298    OG1  CG2                                            
REMARK 470     SER I 299    OG                                                  
REMARK 470     LYS I 346    CG   CD   CE   NZ                                   
REMARK 470     GLU I 402    CG   CD   OE1  OE2                                  
REMARK 470     MET I 411    CG   SD   CE                                        
REMARK 470     LYS I 412    CG   CD   CE   NZ                                   
REMARK 470     GLU I 430    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 439    CG   CD   CE   NZ                                   
REMARK 470     PHE I 470    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS I 480    CG   CD   CE   NZ                                   
REMARK 470     ASP I 481    CG   OD1  OD2                                       
REMARK 470     GLU I 482    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 483    CG   OD1  OD2                                       
REMARK 470     ASP I 484    CG   OD1  OD2                                       
REMARK 470     ASP I 485    CG   OD1  OD2                                       
REMARK 470     LEU I 486    CG   CD1  CD2                                       
REMARK 470     VAL I 487    CG1  CG2                                            
REMARK 470     SER I 488    OG                                                  
REMARK 470     ASN I 495    CG   OD1  ND2                                       
REMARK 470     ARG I 567    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG I 659    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 660    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 662    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 756    CG   CD   OE1  OE2                                  
REMARK 470     ASN J   2    CG   OD1  ND2                                       
REMARK 470     LEU J   3    CG   CD1  CD2                                       
REMARK 470     GLU J   4    CG   CD   OE1  OE2                                  
REMARK 470     ARG J   5    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER J 124    OG                                                  
REMARK 470     GLN J 125    CG   CD   OE1  NE2                                  
REMARK 470     SER J 126    OG                                                  
REMARK 470     GLU J 222    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 347    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 524    CG   CD   OE1  OE2                                  
REMARK 470     ASP J 529    CG   OD1  OD2                                       
REMARK 470     SER J 530    OG                                                  
REMARK 470     GLU J 531    CG   CD   OE1  OE2                                  
REMARK 470     ASN K   2    CG   OD1  ND2                                       
REMARK 470     LEU K   3    CG   CD1  CD2                                       
REMARK 470     GLU K   4    CG   CD   OE1  OE2                                  
REMARK 470     ARG K   5    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS K 214    CG   CD   CE   NZ                                   
REMARK 470     GLU L 164    CG   CD   OE1  OE2                                  
REMARK 470     SER L 165    OG                                                  
REMARK 470     SER L 166    OG                                                  
REMARK 470     ILE L 167    CG1  CG2  CD1                                       
REMARK 470     LYS L 169    CG   CD   CE   NZ                                   
REMARK 470     PHE L 170    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO L 171    CG   CD                                             
REMARK 470     CYS L 172    SG                                                  
REMARK 470     THR L 173    OG1  CG2                                            
REMARK 470     THR L 174    OG1  CG2                                            
REMARK 470     ILE L 175    CG1  CG2  CD1                                       
REMARK 470     ASP L 176    CG   OD1  OD2                                       
REMARK 470     ARG N  15    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO N  16    CG   CD                                             
REMARK 470     GLN N  18    CG   CD   OE1  NE2                                  
REMARK 470     GLU N  19    CG   CD   OE1  OE2                                  
REMARK 470     LEU N  20    CG   CD1  CD2                                       
REMARK 470     LEU N  21    CG   CD1  CD2                                       
REMARK 470     VAL N  22    CG1  CG2                                            
REMARK 470     TRP N  24    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP N  24    CZ3  CH2                                            
REMARK 470     ASN N  25    CG   OD1  ND2                                       
REMARK 470     THR N  26    OG1  CG2                                            
REMARK 470     VAL N  27    CG1  CG2                                            
REMARK 470     SER N  28    OG                                                  
REMARK 470     THR N  29    OG1  CG2                                            
REMARK 470     GLU N  53    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  54    CG   CD   OE1  OE2                                  
REMARK 470     LEU N  55    CG   CD1  CD2                                       
REMARK 470     ARG N  56    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL N  59    CG1  CG2                                            
REMARK 470     GLU N  60    CG   CD   OE1  OE2                                  
REMARK 470     VAL N  61    CG1  CG2                                            
REMARK 470     LEU N  62    CG   CD1  CD2                                       
REMARK 470     ARG N  63    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS N  65    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL N  70    CG1  CG2                                            
REMARK 470     LEU N  71    CG   CD1  CD2                                       
REMARK 470     GLU N  72    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  73    CG   CD   OE1  OE2                                  
REMARK 470     ASN N  93    CG   OD1  ND2                                       
REMARK 470     ILE N  95    CG1  CG2  CD1                                       
REMARK 470     SER N  96    OG                                                  
REMARK 470     GLN N  97    CG   CD   OE1  NE2                                  
REMARK 470     CYS N  98    SG                                                  
REMARK 470     GLU N  99    CG   CD   OE1  OE2                                  
REMARK 470     ASN N 100    CG   OD1  ND2                                       
REMARK 470     SER N 101    OG                                                  
REMARK 470     CYS N 107    SG                                                  
REMARK 470     LEU N 108    CG   CD1  CD2                                       
REMARK 470     LEU N 109    CG   CD1  CD2                                       
REMARK 470     LEU N 110    CG   CD1  CD2                                       
REMARK 470     LEU N 111    CG   CD1  CD2                                       
REMARK 470     LEU N 112    CG   CD1  CD2                                       
REMARK 470     ASP N 113    CG   OD1  OD2                                       
REMARK 470     PHE N 115    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU N 117    CG   CD1  CD2                                       
REMARK 470     LEU N 118    CG   CD1  CD2                                       
REMARK 470     GLU N 119    CG   CD   OE1  OE2                                  
REMARK 470     SER N 120    OG                                                  
REMARK 470     ARG N 121    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU N 122    CG   CD1  CD2                                       
REMARK 470     ASP N 123    CG   OD1  OD2                                       
REMARK 470     LEU N 126    CG   CD1  CD2                                       
REMARK 470     ARG N 127    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER N 128    OG                                                  
REMARK 470     GLU N 130    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 131    CG   CD1  CD2                                       
REMARK 470     LEU N 132    CG   CD1  CD2                                       
REMARK 470     GLU N 133    CG   CD   OE1  OE2                                  
REMARK 470     LYS N 134    CG   CD   CE   NZ                                   
REMARK 470     TRP N 135    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP N 135    CZ3  CH2                                            
REMARK 470     THR N 136    OG1  CG2                                            
REMARK 470     ARG N 137    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU N 138    CG   CD1  CD2                                       
REMARK 470     LEU N 140    CG   CD1  CD2                                       
REMARK 470     LEU N 141    CG   CD1  CD2                                       
REMARK 470     MET N 142    CG   SD   CE                                        
REMARK 470     THR N 144    OG1  CG2                                            
REMARK 470     GLN N 147    CG   CD   OE1  NE2                                  
REMARK 470     SER N 164    OG                                                  
REMARK 470     THR N 165    OG1  CG2                                            
REMARK 470     ASP N 196    CG   OD1  OD2                                       
REMARK 470     PRO N 197    CG   CD                                             
REMARK 470     GLU N 198    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 199    CG   CD1  CD2                                       
REMARK 470     GLU N 200    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 216    CG   CD1  CD2                                       
REMARK 470     GLN N 217    CG   CD   OE1  NE2                                  
REMARK 470     SER N 218    OG                                                  
REMARK 470     PRO N 219    CG   CD                                             
REMARK 470     LEU N 220    CG   CD1  CD2                                       
REMARK 470     GLU N 254    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 294    CG   CD   OE1  OE2                                  
REMARK 470     THR N 443    OG1  CG2                                            
REMARK 470     ASP N 451    CG   OD1  OD2                                       
REMARK 470     LEU N 452    CG   CD1  CD2                                       
REMARK 470     VAL N 454    CG1  CG2                                            
REMARK 470     GLU N 455    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 456    CG   CD1  CD2                                       
REMARK 470     SER N 457    OG                                                  
REMARK 470     LYS N 458    CG   CD   CE   NZ                                   
REMARK 470     GLU N 476    CG   CD   OE1  OE2                                  
REMARK 470     PRO N 477    CG   CD                                             
REMARK 470     GLU N 478    CG   CD   OE1  OE2                                  
REMARK 470     ASP N 479    CG   OD1  OD2                                       
REMARK 470     TRP N 480    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP N 480    CZ3  CH2                                            
REMARK 470     VAL N 481    CG1  CG2                                            
REMARK 470     PRO N 482    CG   CD                                             
REMARK 470     ASP N 483    CG   OD1  OD2                                       
REMARK 470     PRO N 484    CG   CD                                             
REMARK 470     VAL N 485    CG1  CG2                                            
REMARK 470     ASP N 486    CG   OD1  OD2                                       
REMARK 470     ASP N 488    CG   OD1  OD2                                       
REMARK 470     PRO N 489    CG   CD                                             
REMARK 470     LYS N 491    CG   CD   CE   NZ                                   
REMARK 470     SER N 492    OG                                                  
REMARK 470     SER N 493    OG                                                  
REMARK 470     SER N 494    OG                                                  
REMARK 470     LYS N 495    CG   CD   CE   NZ                                   
REMARK 470     ARG N 496    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG N 497    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER N 499    OG                                                  
REMARK 470     LYS O  27    CG   CD   CE   NZ                                   
REMARK 470     THR O  47    OG1  CG2                                            
REMARK 470     GLU O  49    CG   CD   OE1  OE2                                  
REMARK 470     VAL O  52    CG1  CG2                                            
REMARK 470     TYR O  79    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     THR O 122    OG1  CG2                                            
REMARK 470     GLU O 123    CG   CD   OE1  OE2                                  
REMARK 470     LYS O 168    CG   CD   CE   NZ                                   
REMARK 470     THR O 169    OG1  CG2                                            
REMARK 470     LYS O 229    CG   CD   CE   NZ                                   
REMARK 470     GLU O 452    CG   CD   OE1  OE2                                  
REMARK 470     GLN O 742    CG   CD   OE1  NE2                                  
REMARK 470     GLU O 743    CG   CD   OE1  OE2                                  
REMARK 470     SER O 746    OG                                                  
REMARK 470     VAL O 749    CG1  CG2                                            
REMARK 470     GLU P  69    CG   CD   OE1  OE2                                  
REMARK 470     CYS P 109    SG                                                  
REMARK 470     LYS P 161    CG   CD   CE   NZ                                   
REMARK 470     LYS P 281    CG   CD   CE   NZ                                   
REMARK 470     ASP P 496    CG   OD1  OD2                                       
REMARK 470     ILE P 497    CD1                                                 
REMARK 470     SER P 499    OG                                                  
REMARK 470     CYS P 500    SG                                                  
REMARK 470     GLN R 100    CG   CD   OE1  NE2                                  
REMARK 470     VAL R 458    CG1  CG2                                            
REMARK 470     SER R 492    OG                                                  
REMARK 470     LEU R 493    CG   CD1  CD2                                       
REMARK 470     LYS W  24    CG   CD   CE   NZ                                   
REMARK 470     ASP W  25    CG   OD1  OD2                                       
REMARK 470     LYS X 215    CG   CD   CE   NZ                                   
REMARK 470     GLU X 218    CG   CD   OE1  OE2                                  
REMARK 470     MET X 224    CG   SD   CE                                        
REMARK 470     ASN X 225    CG   OD1  ND2                                       
REMARK 470     GLN X 228    CG   CD   OE1  NE2                                  
REMARK 470     ARG X 317    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU X 318    CG   CD   OE1  OE2                                  
REMARK 470     ASN X 440    CG   OD1  ND2                                       
REMARK 470     ARG X 472    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     MET Y 142    CG   SD   CE                                        
REMARK 470     LYS Y 215    CG   CD   CE   NZ                                   
REMARK 470     GLU Y 218    CG   CD   OE1  OE2                                  
REMARK 470     MET Y 224    CG   SD   CE                                        
REMARK 470     ASN Y 225    CG   OD1  ND2                                       
REMARK 470     GLN Y 228    CG   CD   OE1  NE2                                  
REMARK 470     ARG Y 317    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU Y 318    CG   CD   OE1  OE2                                  
REMARK 470     ASN Y 440    CG   OD1  ND2                                       
REMARK 470     ARG Y 472    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    THR A  1225     N    SER A  1229              1.96            
REMARK 500   O    GLY A  1332     CD1  ILE A  1358              2.01            
REMARK 500   OG1  THR C    77     OE1  GLU C    79              2.06            
REMARK 500   CE1  TYR C   115     NZ   LYS C   161              1.63            
REMARK 500   O    ILE C   285     OE1  GLU C   288              2.00            
REMARK 500   O    GLY C   440     N    CYS C   442              2.17            
REMARK 500   O    GLU C   441     N    LYS C   445              2.17            
REMARK 500   O    HIS F    18     OH   TYR H    73              2.18            
REMARK 500   OE2  GLU I   186     NH1  ARG I   197              2.10            
REMARK 500   O    LEU I   214     OG1  THR I   238              2.10            
REMARK 500   OD1  ASP I   679     NH2  ARG I   703              2.18            
REMARK 500   CB   SER J   223     NE2  GLN J   228              2.07            
REMARK 500   O    LYS K   129     SG   CYS K   133              2.13            
REMARK 500   O    LYS K   214     N    SER K   216              2.04            
REMARK 500   CG   LYS N   362     CD2  LEU N   410              2.15            
REMARK 500   O    ASP O   114     OD1  ASP O   117              2.12            
REMARK 500   OD2  ASP R   177     CD1  ILE S   834              2.06            
REMARK 500   O    HIS X    83     OG   SER X    86              2.19            
REMARK 500   O    HIS Y    83     OG   SER Y    86              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    TRP J 302   CB    TRP J 302   CG     -0.114                       
REMARK 500    TYR N 213   C     ARG N 214   N       1.912                       
REMARK 500    PHE O 268   CG    PHE O 268   CD2     0.120                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A1168   CA  -  CB  -  CG  ANGL. DEV. =  14.7 DEGREES          
REMARK 500    LEU A1235   CA  -  CB  -  CG  ANGL. DEV. =  19.4 DEGREES          
REMARK 500    LEU A1409   CB  -  CG  -  CD2 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    LEU A1415   CA  -  CB  -  CG  ANGL. DEV. =  16.0 DEGREES          
REMARK 500    LEU A1556   CA  -  CB  -  CG  ANGL. DEV. =  14.1 DEGREES          
REMARK 500    LEU A1748   CA  -  CB  -  CG  ANGL. DEV. =  14.4 DEGREES          
REMARK 500    LEU C  89   CA  -  CB  -  CG  ANGL. DEV. =  14.1 DEGREES          
REMARK 500    LEU C 179   CA  -  CB  -  CG  ANGL. DEV. =  17.1 DEGREES          
REMARK 500    GLY C 440   N   -  CA  -  C   ANGL. DEV. = -22.2 DEGREES          
REMARK 500    PRO D  23   N   -  CA  -  CB  ANGL. DEV. =   8.4 DEGREES          
REMARK 500    VAL I 223   CB  -  CA  -  C   ANGL. DEV. = -12.9 DEGREES          
REMARK 500    PRO I 489   C   -  N   -  CA  ANGL. DEV. =  10.4 DEGREES          
REMARK 500    PHE I 620   CG  -  CD1 -  CE1 ANGL. DEV. =   7.2 DEGREES          
REMARK 500    LEU J 188   CA  -  CB  -  CG  ANGL. DEV. =  14.9 DEGREES          
REMARK 500    CYS J 267   CA  -  CB  -  SG  ANGL. DEV. =   7.9 DEGREES          
REMARK 500    CYS J 307   CB  -  CA  -  C   ANGL. DEV. =  -7.6 DEGREES          
REMARK 500    ASP K 351   CB  -  CG  -  OD1 ANGL. DEV. =   7.9 DEGREES          
REMARK 500    LEU K 451   CB  -  CG  -  CD2 ANGL. DEV. = -10.5 DEGREES          
REMARK 500    PRO L 171   N   -  CA  -  CB  ANGL. DEV. =   8.1 DEGREES          
REMARK 500    PRO N  16   C   -  N   -  CA  ANGL. DEV. =   9.3 DEGREES          
REMARK 500    GLY N  64   C   -  N   -  CA  ANGL. DEV. =  14.8 DEGREES          
REMARK 500    TYR N 213   CA  -  C   -  N   ANGL. DEV. = -36.4 DEGREES          
REMARK 500    TYR N 213   O   -  C   -  N   ANGL. DEV. =  23.2 DEGREES          
REMARK 500    ARG N 214   C   -  N   -  CA  ANGL. DEV. = -48.4 DEGREES          
REMARK 500    LEU N 215   CA  -  CB  -  CG  ANGL. DEV. =  14.3 DEGREES          
REMARK 500    PRO N 219   N   -  CA  -  CB  ANGL. DEV. =   8.1 DEGREES          
REMARK 500    PRO N 477   N   -  CA  -  CB  ANGL. DEV. =   8.5 DEGREES          
REMARK 500    PRO N 484   N   -  CA  -  CB  ANGL. DEV. =   7.0 DEGREES          
REMARK 500    ASP O 117   CB  -  CG  -  OD1 ANGL. DEV. =  -6.6 DEGREES          
REMARK 500    ASP O 117   CB  -  CG  -  OD2 ANGL. DEV. =   6.1 DEGREES          
REMARK 500    LEU O 616   CA  -  CB  -  CG  ANGL. DEV. =  16.3 DEGREES          
REMARK 500    LEU O 625   CA  -  CB  -  CG  ANGL. DEV. =  14.1 DEGREES          
REMARK 500    LEU O 632   CA  -  CB  -  CG  ANGL. DEV. =  15.3 DEGREES          
REMARK 500    ARG O 730   NE  -  CZ  -  NH1 ANGL. DEV. =   4.6 DEGREES          
REMARK 500    ARG O 730   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.2 DEGREES          
REMARK 500    LEU O 751   CA  -  CB  -  CG  ANGL. DEV. =  16.8 DEGREES          
REMARK 500    LEU P  89   CB  -  CG  -  CD2 ANGL. DEV. =  12.8 DEGREES          
REMARK 500    LEU P 358   CA  -  CB  -  CG  ANGL. DEV. =  22.7 DEGREES          
REMARK 500    LEU X 110   CA  -  CB  -  CG  ANGL. DEV. =  13.9 DEGREES          
REMARK 500    LEU Y  59   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    LEU Y  70   CB  -  CG  -  CD1 ANGL. DEV. =  13.0 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS A  29       37.77    -75.62                                   
REMARK 500    HIS A  30      -24.18   -167.97                                   
REMARK 500    ASN A  33      -60.93     82.20                                   
REMARK 500    GLN A  38       62.67   -102.28                                   
REMARK 500    LEU A  39      -74.36    -56.40                                   
REMARK 500    ALA A  45       63.98    126.80                                   
REMARK 500    GLU A  47      -57.48    -26.55                                   
REMARK 500    LEU A  57     -127.05     54.41                                   
REMARK 500    VAL A  87     -112.67     48.43                                   
REMARK 500    SER A 106       52.72    -91.50                                   
REMARK 500    ASP A 120      -15.70     53.92                                   
REMARK 500    GLN A 125      -48.92   -130.46                                   
REMARK 500    ALA A 126       53.43     31.91                                   
REMARK 500    PRO A 182       41.90    -80.20                                   
REMARK 500    LYS A 184      163.11    -47.27                                   
REMARK 500    TYR A 185      -53.97     75.72                                   
REMARK 500    LEU A 187     -168.38   -128.45                                   
REMARK 500    PRO A 216       18.96    -69.76                                   
REMARK 500    VAL A 240      -74.59   -109.20                                   
REMARK 500    ASP A 241       37.41    159.89                                   
REMARK 500    HIS A 242      -34.67    -35.47                                   
REMARK 500    ASP A 252      -72.10    -62.73                                   
REMARK 500    GLN A 263     -159.94   -103.06                                   
REMARK 500    ASN A 264      -72.24    -51.05                                   
REMARK 500    VAL A 265      110.01   -171.41                                   
REMARK 500    VAL A 274      -39.96    113.97                                   
REMARK 500    LYS A 275     -122.96     55.42                                   
REMARK 500    LEU A 407      109.29     73.36                                   
REMARK 500    HIS A 411      162.24     50.10                                   
REMARK 500    LEU A 412      -30.78   -159.00                                   
REMARK 500    TRP A 413     -113.17    101.55                                   
REMARK 500    THR A 414      -47.97    102.79                                   
REMARK 500    ALA A 427     -173.61    -64.90                                   
REMARK 500    SER A 428      -57.81   -137.79                                   
REMARK 500    VAL A 430       70.10     -2.68                                   
REMARK 500    ASP A 435     -169.34    -76.94                                   
REMARK 500    LEU A 450      -16.14     71.89                                   
REMARK 500    GLN A 451     -169.49    -78.06                                   
REMARK 500    LEU A 452       88.12   -157.80                                   
REMARK 500    PHE A 457      170.26    -59.89                                   
REMARK 500    GLN A 465     -158.05    -99.26                                   
REMARK 500    PRO A 475      -95.77    -63.46                                   
REMARK 500    LYS A 477      -45.09   -159.45                                   
REMARK 500    ASP A 486       55.13     78.27                                   
REMARK 500    ILE A 584      -17.39   -162.53                                   
REMARK 500    HIS A 585      -74.83     61.06                                   
REMARK 500    ASP A 589       74.04     38.74                                   
REMARK 500    HIS A 592       82.61     24.03                                   
REMARK 500    ASN A 593      -26.64     82.99                                   
REMARK 500    THR A 614      -53.29     83.35                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     445 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 GLN A  124     GLN A  125                 -147.99                    
REMARK 500 ASN F  565     SER F  566                  149.06                    
REMARK 500 ASN H  565     SER H  566                  149.12                    
REMARK 500 PRO I  489     PRO I  490                   34.21                    
REMARK 500 GLY I  658     ARG I  659                 -144.27                    
REMARK 500 ILE J  220     PRO J  221                 -138.00                    
REMARK 500 CYS L   36     LYS L   37                  148.83                    
REMARK 500 LEU M   62     GLN M   63                  148.22                    
REMARK 500 GLY N  143     THR N  144                  145.85                    
REMARK 500 TYR N  213     ARG N  214                  141.86                    
REMARK 500 ARG N  367     THR N  368                 -148.72                    
REMARK 500 LEU N  387     HIS N  388                 -142.06                    
REMARK 500 CYS N  394     ASP N  395                  128.87                    
REMARK 500 LYS P  147     ASN P  148                 -148.47                    
REMARK 500 CYS Y  199     PRO Y  200                  -31.94                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    TYR N 213        -11.58                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CHIRAL CENTERS                                             
REMARK 500                                                                      
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL                     
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY                      
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR                        
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE                                    
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN                            
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE                   
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)       
REMARK 500                                                                      
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS                 
REMARK 500    ASP A  88        21.4      L          L   OUTSIDE RANGE           
REMARK 500    VAL A 240        22.2      L          L   OUTSIDE RANGE           
REMARK 500    HIS A 411        22.6      L          L   OUTSIDE RANGE           
REMARK 500    TRP A 413        22.8      L          L   OUTSIDE RANGE           
REMARK 500    HIS A 585        24.6      L          L   OUTSIDE RANGE           
REMARK 500    ILE A 759        23.7      L          L   OUTSIDE RANGE           
REMARK 500    VAL A 791        25.0      L          L   OUTSIDE RANGE           
REMARK 500    LYS A 798        23.0      L          L   OUTSIDE RANGE           
REMARK 500    THR A1597        25.0      L          L   OUTSIDE RANGE           
REMARK 500    ASP A1694        24.4      L          L   OUTSIDE RANGE           
REMARK 500    THR A1808        24.2      L          L   OUTSIDE RANGE           
REMARK 500    SER C  27        22.2      L          L   OUTSIDE RANGE           
REMARK 500    LEU C 106        24.7      L          L   OUTSIDE RANGE           
REMARK 500    ASN C 361        16.1      L          L   OUTSIDE RANGE           
REMARK 500    LYS C 524        23.4      L          L   OUTSIDE RANGE           
REMARK 500    ASN F 145        24.5      L          L   OUTSIDE RANGE           
REMARK 500    GLN F 667        19.0      L          L   OUTSIDE RANGE           
REMARK 500    LYS F 701        21.7      L          L   OUTSIDE RANGE           
REMARK 500    ASP H  23        24.4      L          L   OUTSIDE RANGE           
REMARK 500    ASN H 145        24.3      L          L   OUTSIDE RANGE           
REMARK 500    THR I  40        24.9      L          L   OUTSIDE RANGE           
REMARK 500    TYR J  69        21.9      L          L   OUTSIDE RANGE           
REMARK 500    LEU J 451        21.6      L          L   OUTSIDE RANGE           
REMARK 500    HIS K 173        21.9      L          L   OUTSIDE RANGE           
REMARK 500    LYS K 365        24.8      L          L   OUTSIDE RANGE           
REMARK 500    LEU L 124        24.9      L          L   OUTSIDE RANGE           
REMARK 500    ARG N  63        19.8      L          L   OUTSIDE RANGE           
REMARK 500    VAL N  76        23.4      L          L   OUTSIDE RANGE           
REMARK 500    TYR N 125        24.6      L          L   OUTSIDE RANGE           
REMARK 500    THR N 144        24.5      L          L   OUTSIDE RANGE           
REMARK 500    THR N 368        24.2      L          L   OUTSIDE RANGE           
REMARK 500    LEU N 386        23.7      L          L   OUTSIDE RANGE           
REMARK 500    ASP N 395        16.7      L          L   OUTSIDE RANGE           
REMARK 500    ARG N 497        24.9      L          L   OUTSIDE RANGE           
REMARK 500    SER O 357        24.3      L          L   OUTSIDE RANGE           
REMARK 500    ILE O 657        24.5      L          L   OUTSIDE RANGE           
REMARK 500    ILE P 244        24.7      L          L   OUTSIDE RANGE           
REMARK 500    ASN P 361        15.2      L          L   OUTSIDE RANGE           
REMARK 500    ASP P 464        22.2      L          L   OUTSIDE RANGE           
REMARK 500    LYS P 524        23.4      L          L   OUTSIDE RANGE           
REMARK 500    CYS Y 199        17.9      L          L   OUTSIDE RANGE           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  ZN B1085                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  ZN B1086                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  ZN B1087                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 5G05   RELATED DB: PDB                                   
REMARK 900  CRYO-EM STRUCTURE OF COMBINED APO PHOSPHORYLATED APC                
REMARK 900 RELATED ID: EMD-3385 RELATED DB: EMDB                                
DBREF  5G04 A    1  1944  UNP    Q9H1A4   APC1_HUMAN       1   1944             
DBREF  5G04 B    1    84  UNP    Q9NYG5   APC11_HUMAN      1     84             
DBREF  5G04 C    1   597  UNP    Q9UJX2   CDC23_HUMAN      1    597             
DBREF  5G04 D    1   121  UNP    P60006   APC15_HUMAN      1    121             
DBREF  5G04 E    1   110  UNP    Q96DE5   APC16_HUMAN      1    110             
DBREF  5G04 F    1   824  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  5G04 G    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  5G04 H    1   824  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  5G04 I    1   808  UNP    Q9UJX5   APC4_HUMAN       1    808             
DBREF  5G04 J    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  5G04 K    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  5G04 L    1   184  UNP    Q9UM13   APC10_HUMAN      1    185             
DBREF  5G04 M    1    74  UNP    Q9BS18   APC13_HUMAN      1     74             
DBREF  5G04 N    1   822  UNP    Q9UJX6   ANC2_HUMAN       1    822             
DBREF  5G04 O    1   755  UNP    Q9UJX4   APC5_HUMAN       1    755             
DBREF  5G04 P    1   597  UNP    Q9UJX2   CDC23_HUMAN      1    597             
DBREF  5G04 R    1   499  UNP    Q12834   CDC20_HUMAN      1    499             
DBREF  5G04 S  667   872  UNP    P34244   HSL1_YEAST     667    872             
DBREF  5G04 W    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  5G04 X    1   599  UNP    Q9UJX3   APC7_HUMAN       1    599             
DBREF  5G04 Y    1   599  UNP    Q9UJX3   APC7_HUMAN       1    599             
SEQADV 5G04     L       UNP  Q9UM13    ARG   172 DELETION                       
SEQRES   1 A 1944  MET SER ASN PHE TYR GLU GLU ARG THR THR MET ILE ALA          
SEQRES   2 A 1944  ALA ARG ASP LEU GLN GLU PHE VAL PRO PHE GLY ARG ASP          
SEQRES   3 A 1944  HIS CYS LYS HIS HIS PRO ASN ALA LEU ASN LEU GLN LEU          
SEQRES   4 A 1944  ARG GLN LEU GLN PRO ALA SER GLU LEU TRP SER SER ASP          
SEQRES   5 A 1944  GLY ALA ALA GLY LEU VAL GLY SER LEU GLN GLU VAL THR          
SEQRES   6 A 1944  ILE HIS GLU LYS GLN LYS GLU SER TRP GLN LEU ARG LYS          
SEQRES   7 A 1944  GLY VAL SER GLU ILE GLY GLU ASP VAL ASP TYR ASP GLU          
SEQRES   8 A 1944  GLU LEU TYR VAL ALA GLY ASN MET VAL ILE TRP SER LYS          
SEQRES   9 A 1944  GLY SER LYS SER GLN ALA LEU ALA VAL TYR LYS ALA PHE          
SEQRES  10 A 1944  THR VAL ASP SER PRO VAL GLN GLN ALA LEU TRP CYS ASP          
SEQRES  11 A 1944  PHE ILE ILE SER GLN ASP LYS SER GLU LYS ALA TYR SER          
SEQRES  12 A 1944  SER ASN GLU VAL GLU LYS CYS ILE CYS ILE LEU GLN SER          
SEQRES  13 A 1944  SER CYS ILE ASN MET HIS SER ILE GLU GLY LYS ASP TYR          
SEQRES  14 A 1944  ILE ALA SER LEU PRO PHE GLN VAL ALA ASN VAL TRP PRO          
SEQRES  15 A 1944  THR LYS TYR GLY LEU LEU PHE GLU ARG SER ALA SER SER          
SEQRES  16 A 1944  HIS GLU VAL PRO PRO GLY SER PRO ARG GLU PRO LEU PRO          
SEQRES  17 A 1944  THR MET PHE SER MET LEU HIS PRO LEU ASP GLU ILE THR          
SEQRES  18 A 1944  PRO LEU VAL CYS LYS SER GLY SER LEU PHE GLY SER SER          
SEQRES  19 A 1944  ARG VAL GLN TYR VAL VAL ASP HIS ALA MET LYS ILE VAL          
SEQRES  20 A 1944  PHE LEU ASN THR ASP PRO SER ILE VAL MET THR TYR ASP          
SEQRES  21 A 1944  ALA VAL GLN ASN VAL HIS SER VAL TRP THR LEU ARG ARG          
SEQRES  22 A 1944  VAL LYS SER GLU GLU GLU ASN VAL VAL LEU LYS PHE SER          
SEQRES  23 A 1944  GLU GLN GLY GLY THR PRO GLN ASN VAL ALA THR SER SER          
SEQRES  24 A 1944  SER LEU THR ALA HIS LEU ARG SER LEU SER LYS GLY ASP          
SEQRES  25 A 1944  SER PRO VAL THR SER PRO PHE GLN ASN TYR SER SER ILE          
SEQRES  26 A 1944  HIS SER GLN SER ARG SER THR SER SER PRO SER LEU HIS          
SEQRES  27 A 1944  SER ARG SER PRO SER ILE SER ASN MET ALA ALA LEU SER          
SEQRES  28 A 1944  ARG ALA HIS SER PRO ALA LEU GLY VAL HIS SER PHE SER          
SEQRES  29 A 1944  GLY VAL GLN ARG PHE ASN ILE SER SER HIS ASN GLN SER          
SEQRES  30 A 1944  PRO LYS ARG HIS SER ILE SER HIS SER PRO ASN SER ASN          
SEQRES  31 A 1944  SER ASN GLY SER PHE LEU ALA PRO GLU THR GLU PRO ILE          
SEQRES  32 A 1944  VAL PRO GLU LEU CYS ILE ASP HIS LEU TRP THR GLU THR          
SEQRES  33 A 1944  ILE THR ASN ILE ARG GLU LYS ASN SER GLN ALA SER LYS          
SEQRES  34 A 1944  VAL PHE ILE THR SER ASP LEU CYS GLY GLN LYS PHE LEU          
SEQRES  35 A 1944  CYS PHE LEU VAL GLU SER GLN LEU GLN LEU ARG CYS VAL          
SEQRES  36 A 1944  LYS PHE GLN GLU SER ASN ASP LYS THR GLN LEU ILE PHE          
SEQRES  37 A 1944  GLY SER VAL THR ASN ILE PRO ALA LYS ASP ALA ALA PRO          
SEQRES  38 A 1944  VAL GLU LYS ILE ASP THR MET LEU VAL LEU GLU GLY SER          
SEQRES  39 A 1944  GLY ASN LEU VAL LEU TYR THR GLY VAL VAL ARG VAL GLY          
SEQRES  40 A 1944  LYS VAL PHE ILE PRO GLY LEU PRO ALA PRO SER LEU THR          
SEQRES  41 A 1944  MET SER ASN THR MET PRO ARG PRO SER THR PRO LEU ASP          
SEQRES  42 A 1944  GLY VAL SER THR PRO LYS PRO LEU SER LYS LEU LEU GLY          
SEQRES  43 A 1944  SER LEU ASP GLU VAL VAL LEU LEU SER PRO VAL PRO GLU          
SEQRES  44 A 1944  LEU ARG ASP SER SER LYS LEU HIS ASP SER LEU TYR ASN          
SEQRES  45 A 1944  GLU ASP CYS THR PHE GLN GLN LEU GLY THR TYR ILE HIS          
SEQRES  46 A 1944  SER ILE ARG ASP PRO VAL HIS ASN ARG VAL THR LEU GLU          
SEQRES  47 A 1944  LEU SER ASN GLY SER MET VAL ARG ILE THR ILE PRO GLU          
SEQRES  48 A 1944  ILE ALA THR SER GLU LEU VAL GLN THR CYS LEU GLN ALA          
SEQRES  49 A 1944  ILE LYS PHE ILE LEU PRO LYS GLU ILE ALA VAL GLN MET          
SEQRES  50 A 1944  LEU VAL LYS TRP TYR ASN VAL HIS SER ALA PRO GLY GLY          
SEQRES  51 A 1944  PRO SER TYR HIS SER GLU TRP ASN LEU PHE VAL THR CYS          
SEQRES  52 A 1944  LEU MET ASN MET MET GLY TYR ASN THR ASP ARG LEU ALA          
SEQRES  53 A 1944  TRP THR ARG ASN PHE ASP PHE GLU GLY SER LEU SER PRO          
SEQRES  54 A 1944  VAL ILE ALA PRO LYS LYS ALA ARG PRO SER GLU THR GLY          
SEQRES  55 A 1944  SER ASP ASP ASP TRP GLU TYR LEU LEU ASN SER ASP TYR          
SEQRES  56 A 1944  HIS GLN ASN VAL GLU SER HIS LEU LEU ASN ARG SER LEU          
SEQRES  57 A 1944  CYS LEU SER PRO SER GLU ALA SER GLN MET LYS ASP GLU          
SEQRES  58 A 1944  ASP PHE SER GLN ASN LEU SER LEU ASP SER SER THR LEU          
SEQRES  59 A 1944  LEU PHE THR HIS ILE PRO ALA ILE PHE PHE VAL LEU HIS          
SEQRES  60 A 1944  LEU VAL TYR GLU GLU LEU LYS LEU ASN THR LEU MET GLY          
SEQRES  61 A 1944  GLU GLY ILE CYS SER LEU VAL GLU LEU LEU VAL GLN LEU          
SEQRES  62 A 1944  ALA ARG ASP LEU LYS LEU GLY PRO TYR VAL ASP HIS TYR          
SEQRES  63 A 1944  TYR ARG ASP TYR PRO THR LEU VAL ARG THR THR GLY GLN          
SEQRES  64 A 1944  VAL CYS THR ILE ASP PRO GLY GLN THR GLY PHE MET HIS          
SEQRES  65 A 1944  HIS PRO SER PHE PHE THR SER GLU PRO PRO SER ILE TYR          
SEQRES  66 A 1944  GLN TRP VAL SER SER CYS LEU LYS GLY GLU GLY MET PRO          
SEQRES  67 A 1944  PRO TYR PRO TYR LEU PRO GLY ILE CYS GLU ARG SER ARG          
SEQRES  68 A 1944  LEU VAL VAL LEU SER ILE ALA LEU TYR ILE LEU GLY ASP          
SEQRES  69 A 1944  GLU SER LEU VAL SER ASP GLU SER SER GLN TYR LEU THR          
SEQRES  70 A 1944  ARG ILE THR ILE ALA PRO GLN LYS LEU GLN VAL GLU GLN          
SEQRES  71 A 1944  GLU GLU ASN ARG PHE SER PHE ARG HIS SER THR SER VAL          
SEQRES  72 A 1944  SER SER LEU ALA GLU ARG LEU VAL VAL TRP MET THR ASN          
SEQRES  73 A 1944  VAL GLY PHE THR LEU ARG ASP LEU GLU THR LEU PRO PHE          
SEQRES  74 A 1944  GLY ILE ALA LEU PRO ILE ARG ASP ALA ILE TYR HIS CYS          
SEQRES  75 A 1944  ARG GLU GLN PRO ALA SER ASP TRP PRO GLU ALA VAL CYS          
SEQRES  76 A 1944  LEU LEU ILE GLY ARG GLN ASP LEU SER LYS GLN ALA CYS          
SEQRES  77 A 1944  GLU GLY ASN LEU PRO LYS GLY LYS SER VAL LEU SER SER          
SEQRES  78 A 1944  ASP VAL PRO SER GLY THR GLU THR GLU GLU GLU ASP ASP          
SEQRES  79 A 1944  GLY MET ASN ASP MET ASN HIS GLU VAL MET SER LEU ILE          
SEQRES  80 A 1944  TRP SER GLU ASP LEU ARG VAL GLN ASP VAL ARG ARG LEU          
SEQRES  81 A 1944  LEU GLN SER ALA HIS PRO VAL ARG VAL ASN VAL VAL GLN          
SEQRES  82 A 1944  TYR PRO GLU LEU SER ASP HIS GLU PHE ILE GLU GLU LYS          
SEQRES  83 A 1944  GLU ASN ARG LEU LEU GLN LEU CYS GLN ARG THR MET ALA          
SEQRES  84 A 1944  LEU PRO VAL GLY ARG GLY MET PHE THR LEU PHE SER TYR          
SEQRES  85 A 1944  HIS PRO VAL PRO THR GLU PRO LEU PRO ILE PRO LYS LEU          
SEQRES  86 A 1944  ASN LEU THR GLY ARG ALA PRO PRO ARG ASN THR THR VAL          
SEQRES  87 A 1944  ASP LEU ASN SER GLY ASN ILE ASP VAL PRO PRO ASN MET          
SEQRES  88 A 1944  THR SER TRP ALA SER PHE HIS ASN GLY VAL ALA ALA GLY          
SEQRES  89 A 1944  LEU LYS ILE ALA PRO ALA SER GLN ILE ASP SER ALA TRP          
SEQRES  90 A 1944  ILE VAL TYR ASN LYS PRO LYS HIS ALA GLU LEU ALA ASN          
SEQRES  91 A 1944  GLU TYR ALA GLY PHE LEU MET ALA LEU GLY LEU ASN GLY          
SEQRES  92 A 1944  HIS LEU THR LYS LEU ALA THR LEU ASN ILE HIS ASP TYR          
SEQRES  93 A 1944  LEU THR LYS GLY HIS GLU MET THR SER ILE GLY LEU LEU          
SEQRES  94 A 1944  LEU GLY VAL SER ALA ALA LYS LEU GLY THR MET ASP MET          
SEQRES  95 A 1944  SER ILE THR ARG LEU LEU SER ILE HIS ILE PRO ALA LEU          
SEQRES  96 A 1944  LEU PRO PRO THR SER THR GLU LEU ASP VAL PRO HIS ASN          
SEQRES  97 A 1944  VAL GLN VAL ALA ALA VAL VAL GLY ILE GLY LEU VAL TYR          
SEQRES  98 A 1944  GLN GLY THR ALA HIS ARG HIS THR ALA GLU VAL LEU LEU          
SEQRES  99 A 1944  ALA GLU ILE GLY ARG PRO PRO GLY PRO GLU MET GLU TYR          
SEQRES 100 A 1944  CYS THR ASP ARG GLU SER TYR SER LEU ALA ALA GLY LEU          
SEQRES 101 A 1944  ALA LEU GLY MET VAL CYS LEU GLY HIS GLY SER ASN LEU          
SEQRES 102 A 1944  ILE GLY MET SER ASP LEU ASN VAL PRO GLU GLN LEU TYR          
SEQRES 103 A 1944  GLN TYR MET VAL GLY GLY HIS ARG ARG PHE GLN THR GLY          
SEQRES 104 A 1944  MET HIS ARG GLU LYS HIS LYS SER PRO SER TYR GLN ILE          
SEQRES 105 A 1944  LYS GLU GLY ASP THR ILE ASN VAL ASP VAL THR CYS PRO          
SEQRES 106 A 1944  GLY ALA THR LEU ALA LEU ALA MET ILE TYR LEU LYS THR          
SEQRES 107 A 1944  ASN ASN ARG SER ILE ALA ASP TRP LEU ARG ALA PRO ASP          
SEQRES 108 A 1944  THR MET TYR LEU LEU ASP PHE VAL LYS PRO GLU PHE LEU          
SEQRES 109 A 1944  LEU LEU ARG THR LEU ALA ARG CYS LEU ILE LEU TRP ASP          
SEQRES 110 A 1944  ASP ILE LEU PRO ASN SER LYS TRP VAL ASP SER ASN VAL          
SEQRES 111 A 1944  PRO GLN ILE ILE ARG GLU ASN SER ILE SER LEU SER GLU          
SEQRES 112 A 1944  ILE GLU LEU PRO CYS SER GLU ASP LEU ASN LEU GLU THR          
SEQRES 113 A 1944  LEU SER GLN ALA HIS VAL TYR ILE ILE ALA GLY ALA CYS          
SEQRES 114 A 1944  LEU SER LEU GLY PHE ARG PHE ALA GLY SER GLU ASN LEU          
SEQRES 115 A 1944  SER ALA PHE ASN CYS LEU HIS LYS PHE ALA LYS ASP PHE          
SEQRES 116 A 1944  MET THR TYR LEU SER ALA PRO ASN ALA SER VAL THR GLY          
SEQRES 117 A 1944  PRO HIS ASN LEU GLU THR CYS LEU SER VAL VAL LEU LEU          
SEQRES 118 A 1944  SER LEU ALA MET VAL MET ALA GLY SER GLY ASN LEU LYS          
SEQRES 119 A 1944  VAL LEU GLN LEU CYS ARG PHE LEU HIS MET LYS THR GLY          
SEQRES 120 A 1944  GLY GLU MET ASN TYR GLY PHE HIS LEU ALA HIS HIS MET          
SEQRES 121 A 1944  ALA LEU GLY LEU LEU PHE LEU GLY GLY GLY ARG TYR SER          
SEQRES 122 A 1944  LEU SER THR SER ASN SER SER ILE ALA ALA LEU LEU CYS          
SEQRES 123 A 1944  ALA LEU TYR PRO HIS PHE PRO ALA HIS SER THR ASP ASN          
SEQRES 124 A 1944  ARG TYR HIS LEU GLN ALA LEU ARG HIS LEU TYR VAL LEU          
SEQRES 125 A 1944  ALA ALA GLU PRO ARG LEU LEU VAL PRO VAL ASP VAL ASP          
SEQRES 126 A 1944  THR ASN THR PRO CYS TYR ALA LEU LEU GLU VAL THR TYR          
SEQRES 127 A 1944  LYS GLY THR GLN TRP TYR GLU GLN THR LYS GLU GLU LEU          
SEQRES 128 A 1944  MET ALA PRO THR LEU LEU PRO GLU LEU HIS LEU LEU LYS          
SEQRES 129 A 1944  GLN ILE LYS VAL LYS GLY PRO ARG TYR TRP GLU LEU LEU          
SEQRES 130 A 1944  ILE ASP LEU SER LYS GLY THR GLN HIS LEU LYS SER ILE          
SEQRES 131 A 1944  LEU SER LYS ASP GLY VAL LEU TYR VAL LYS LEU ARG ALA          
SEQRES 132 A 1944  GLY GLN LEU SER TYR LYS GLU ASP PRO MET GLY TRP GLN          
SEQRES 133 A 1944  SER LEU LEU ALA GLN THR VAL ALA ASN ARG ASN SER GLU          
SEQRES 134 A 1944  ALA ARG ALA PHE LYS PRO GLU THR ILE SER ALA PHE THR          
SEQRES 135 A 1944  SER ASP PRO ALA LEU LEU SER PHE ALA GLU TYR PHE CYS          
SEQRES 136 A 1944  LYS PRO THR VAL ASN MET GLY GLN LYS GLN GLU ILE LEU          
SEQRES 137 A 1944  ASP LEU PHE SER SER VAL LEU TYR GLU CYS VAL THR GLN          
SEQRES 138 A 1944  GLU THR PRO GLU MET LEU PRO ALA TYR ILE ALA MET ASP          
SEQRES 139 A 1944  GLN ALA ILE ARG ARG LEU GLY ARG ARG GLU MET SER GLU          
SEQRES 140 A 1944  THR SER GLU LEU TRP GLN ILE LYS LEU VAL LEU GLU PHE          
SEQRES 141 A 1944  PHE SER SER ARG SER HIS GLN GLU ARG LEU GLN ASN HIS          
SEQRES 142 A 1944  PRO LYS ARG GLY LEU PHE MET ASN SER GLU PHE LEU PRO          
SEQRES 143 A 1944  VAL VAL LYS CYS THR ILE ASP ASN THR LEU ASP GLN TRP          
SEQRES 144 A 1944  LEU GLN VAL GLY GLY ASP MET CYS VAL HIS ALA TYR LEU          
SEQRES 145 A 1944  SER GLY GLN PRO LEU GLU GLU SER GLN LEU SER MET LEU          
SEQRES 146 A 1944  ALA CYS PHE LEU VAL TYR HIS SER VAL PRO ALA PRO GLN          
SEQRES 147 A 1944  HIS LEU PRO PRO ILE GLY LEU GLU GLY SER THR SER PHE          
SEQRES 148 A 1944  ALA GLU LEU LEU PHE LYS PHE LYS GLN LEU LYS MET PRO          
SEQRES 149 A 1944  VAL ARG ALA LEU LEU ARG LEU ALA PRO LEU LEU LEU GLY          
SEQRES 150 A 1944  ASN PRO GLN PRO MET VAL MET                                  
SEQRES   1 B   84  MET LYS VAL LYS ILE LYS CYS TRP ASN GLY VAL ALA THR          
SEQRES   2 B   84  TRP LEU TRP VAL ALA ASN ASP GLU ASN CYS GLY ILE CYS          
SEQRES   3 B   84  ARG MET ALA PHE ASN GLY CYS CYS PRO ASP CYS LYS VAL          
SEQRES   4 B   84  PRO GLY ASP ASP CYS PRO LEU VAL TRP GLY GLN CYS SER          
SEQRES   5 B   84  HIS CYS PHE HIS MET HIS CYS ILE LEU LYS TRP LEU HIS          
SEQRES   6 B   84  ALA GLN GLN VAL GLN GLN HIS CYS PRO MET CYS ARG GLN          
SEQRES   7 B   84  GLU TRP LYS PHE LYS GLU                                      
SEQRES   1 C  597  MET ALA ALA SER THR SER MET VAL PRO VAL ALA VAL THR          
SEQRES   2 C  597  ALA ALA VAL ALA PRO VAL LEU SER ILE ASN SER ASP PHE          
SEQRES   3 C  597  SER ASP LEU ARG GLU ILE LYS LYS GLN LEU LEU LEU ILE          
SEQRES   4 C  597  ALA GLY LEU THR ARG GLU ARG GLY LEU LEU HIS SER SER          
SEQRES   5 C  597  LYS TRP SER ALA GLU LEU ALA PHE SER LEU PRO ALA LEU          
SEQRES   6 C  597  PRO LEU ALA GLU LEU GLN PRO PRO PRO PRO ILE THR GLU          
SEQRES   7 C  597  GLU ASP ALA GLN ASP MET ASP ALA TYR THR LEU ALA LYS          
SEQRES   8 C  597  ALA TYR PHE ASP VAL LYS GLU TYR ASP ARG ALA ALA HIS          
SEQRES   9 C  597  PHE LEU HIS GLY CYS ASN SER LYS LYS ALA TYR PHE LEU          
SEQRES  10 C  597  TYR MET TYR SER ARG TYR LEU SER GLY GLU LYS LYS LYS          
SEQRES  11 C  597  ASP ASP GLU THR VAL ASP SER LEU GLY PRO LEU GLU LYS          
SEQRES  12 C  597  GLY GLN VAL LYS ASN GLU ALA LEU ARG GLU LEU ARG VAL          
SEQRES  13 C  597  GLU LEU SER LYS LYS HIS GLN ALA ARG GLU LEU ASP GLY          
SEQRES  14 C  597  PHE GLY LEU TYR LEU TYR GLY VAL VAL LEU ARG LYS LEU          
SEQRES  15 C  597  ASP LEU VAL LYS GLU ALA ILE ASP VAL PHE VAL GLU ALA          
SEQRES  16 C  597  THR HIS VAL LEU PRO LEU HIS TRP GLY ALA TRP LEU GLU          
SEQRES  17 C  597  LEU CYS ASN LEU ILE THR ASP LYS GLU MET LEU LYS PHE          
SEQRES  18 C  597  LEU SER LEU PRO ASP THR TRP MET LYS GLU PHE PHE LEU          
SEQRES  19 C  597  ALA HIS ILE TYR THR GLU LEU GLN LEU ILE GLU GLU ALA          
SEQRES  20 C  597  LEU GLN LYS TYR GLN ASN LEU ILE ASP VAL GLY PHE SER          
SEQRES  21 C  597  LYS SER SER TYR ILE VAL SER GLN ILE ALA VAL ALA TYR          
SEQRES  22 C  597  HIS ASN ILE ARG ASP ILE ASP LYS ALA LEU SER ILE PHE          
SEQRES  23 C  597  ASN GLU LEU ARG LYS GLN ASP PRO TYR ARG ILE GLU ASN          
SEQRES  24 C  597  MET ASP THR PHE SER ASN LEU LEU TYR VAL ARG SER MET          
SEQRES  25 C  597  LYS SER GLU LEU SER TYR LEU ALA HIS ASN LEU CYS GLU          
SEQRES  26 C  597  ILE ASP LYS TYR ARG VAL GLU THR CYS CYS VAL ILE GLY          
SEQRES  27 C  597  ASN TYR TYR SER LEU ARG SER GLN HIS GLU LYS ALA ALA          
SEQRES  28 C  597  LEU TYR PHE GLN ARG ALA LEU LYS LEU ASN PRO ARG TYR          
SEQRES  29 C  597  LEU GLY ALA TRP THR LEU MET GLY HIS GLU TYR MET GLU          
SEQRES  30 C  597  MET LYS ASN THR SER ALA ALA ILE GLN ALA TYR ARG HIS          
SEQRES  31 C  597  ALA ILE GLU VAL ASN LYS ARG ASP TYR ARG ALA TRP TYR          
SEQRES  32 C  597  GLY LEU GLY GLN THR TYR GLU ILE LEU LYS MET PRO PHE          
SEQRES  33 C  597  TYR CYS LEU TYR TYR TYR ARG ARG ALA HIS GLN LEU ARG          
SEQRES  34 C  597  PRO ASN ASP SER ARG MET LEU VAL ALA LEU GLY GLU CYS          
SEQRES  35 C  597  TYR GLU LYS LEU ASN GLN LEU VAL GLU ALA LYS LYS CYS          
SEQRES  36 C  597  TYR TRP ARG ALA TYR ALA VAL GLY ASP VAL GLU LYS MET          
SEQRES  37 C  597  ALA LEU VAL LYS LEU ALA LYS LEU HIS GLU GLN LEU THR          
SEQRES  38 C  597  GLU SER GLU GLN ALA ALA GLN CYS TYR ILE LYS TYR ILE          
SEQRES  39 C  597  GLN ASP ILE TYR SER CYS GLY GLU ILE VAL GLU HIS LEU          
SEQRES  40 C  597  GLU GLU SER THR ALA PHE ARG TYR LEU ALA GLN TYR TYR          
SEQRES  41 C  597  PHE LYS CYS LYS LEU TRP ASP GLU ALA SER THR CYS ALA          
SEQRES  42 C  597  GLN LYS CYS CYS ALA PHE ASN ASP THR ARG GLU GLU GLY          
SEQRES  43 C  597  LYS ALA LEU LEU ARG GLN ILE LEU GLN LEU ARG ASN GLN          
SEQRES  44 C  597  GLY GLU THR PRO THR THR GLU VAL PRO ALA PRO PHE PHE          
SEQRES  45 C  597  LEU PRO ALA SER LEU SER ALA ASN ASN THR PRO THR ARG          
SEQRES  46 C  597  ARG VAL SER PRO LEU ASN LEU SER SER VAL THR PRO              
SEQRES   1 D  121  MET SER THR LEU PHE PRO SER LEU PHE PRO ARG VAL THR          
SEQRES   2 D  121  GLU THR LEU TRP PHE ASN LEU ASP ARG PRO CYS VAL GLU          
SEQRES   3 D  121  GLU THR GLU LEU GLN GLN GLN GLU GLN GLN HIS GLN ALA          
SEQRES   4 D  121  TRP LEU GLN SER ILE ALA GLU LYS ASP ASN ASN LEU VAL          
SEQRES   5 D  121  PRO ILE GLY LYS PRO ALA SER GLU HIS TYR ASP ASP GLU          
SEQRES   6 D  121  GLU GLU GLU ASP ASP GLU ASP ASP GLU ASP SER GLU GLU          
SEQRES   7 D  121  ASP SER GLU ASP ASP GLU ASP MET GLN ASP MET ASP GLU          
SEQRES   8 D  121  MET ASN ASP TYR ASN GLU SER PRO ASP ASP GLY GLU VAL          
SEQRES   9 D  121  ASN GLU VAL ASP MET GLU GLY ASN GLU GLN ASP GLN ASP          
SEQRES  10 D  121  GLN TRP MET ILE                                              
SEQRES   1 E  110  MET ALA ALA SER SER SER SER SER SER ALA GLY GLY VAL          
SEQRES   2 E  110  SER GLY SER SER VAL THR GLY SER GLY PHE SER VAL SER          
SEQRES   3 E  110  ASP LEU ALA PRO PRO ARG LYS ALA LEU PHE THR TYR PRO          
SEQRES   4 E  110  LYS GLY ALA GLY GLU MET LEU GLU ASP GLY SER GLU ARG          
SEQRES   5 E  110  PHE LEU CYS GLU SER VAL PHE SER TYR GLN VAL ALA SER          
SEQRES   6 E  110  THR LEU LYS GLN VAL LYS HIS ASP GLN GLN VAL ALA ARG          
SEQRES   7 E  110  MET GLU LYS LEU ALA GLY LEU VAL GLU GLU LEU GLU ALA          
SEQRES   8 E  110  ASP GLU TRP ARG PHE LYS PRO ILE GLU GLN LEU LEU GLY          
SEQRES   9 E  110  PHE THR PRO SER SER GLY                                      
SEQRES   1 F  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 F  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 F  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 F  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 F  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 F  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 F  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 F  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 F  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 F  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 F  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 F  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 F  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 F  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 F  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 F  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 F  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 F  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 F  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 F  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 F  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 F  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 F  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 F  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 F  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 F  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 F  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 F  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 F  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 F  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 F  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO LYS          
SEQRES  32 F  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 F  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 F  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 F  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 F  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 F  824  MET GLY LYS GLY TYR LEU ALA LEU CYS SER TYR ASN CYS          
SEQRES  38 F  824  LYS GLU ALA ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 F  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 F  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 F  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 F  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 F  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 F  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 F  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 F  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 F  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 F  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 F  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 F  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 F  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 F  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 F  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 F  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 F  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 F  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 F  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 F  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 F  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 F  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 F  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 F  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 F  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 F  824  GLU SER ASP GLU PHE                                          
SEQRES   1 G   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 G   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 G   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 G   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 G   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 G   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 G   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 H  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 H  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 H  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 H  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 H  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 H  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 H  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 H  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 H  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 H  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 H  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 H  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 H  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 H  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 H  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 H  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 H  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 H  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 H  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 H  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 H  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 H  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 H  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 H  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 H  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 H  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 H  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 H  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 H  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 H  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 H  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO LYS          
SEQRES  32 H  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 H  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 H  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 H  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 H  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 H  824  MET GLY LYS GLY TYR LEU ALA LEU CYS SER TYR ASN CYS          
SEQRES  38 H  824  LYS GLU ALA ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 H  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 H  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 H  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 H  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 H  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 H  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 H  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 H  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 H  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 H  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 H  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 H  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 H  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 H  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 H  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 H  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 H  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 H  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 H  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 H  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 H  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 H  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 H  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 H  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 H  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 H  824  GLU SER ASP GLU PHE                                          
SEQRES   1 I  808  MET LEU ARG PHE PRO THR CYS PHE PRO SER PHE ARG VAL          
SEQRES   2 I  808  VAL GLY GLU LYS GLN LEU PRO GLN GLU ILE ILE PHE LEU          
SEQRES   3 I  808  VAL TRP SER PRO LYS ARG ASP LEU ILE ALA LEU ALA ASN          
SEQRES   4 I  808  THR ALA GLY GLU VAL LEU LEU HIS ARG LEU ALA SER PHE          
SEQRES   5 I  808  HIS ARG VAL TRP SER PHE PRO PRO ASN GLU ASN THR GLY          
SEQRES   6 I  808  LYS GLU VAL THR CYS LEU ALA TRP ARG PRO ASP GLY LYS          
SEQRES   7 I  808  LEU LEU ALA PHE ALA LEU ALA ASP THR LYS LYS ILE VAL          
SEQRES   8 I  808  LEU CYS ASP VAL GLU LYS PRO GLU SER LEU HIS SER PHE          
SEQRES   9 I  808  SER VAL GLU ALA PRO VAL SER CYS MET HIS TRP MET GLU          
SEQRES  10 I  808  VAL THR VAL GLU SER SER VAL LEU THR SER PHE TYR ASN          
SEQRES  11 I  808  ALA GLU ASP GLU SER ASN LEU LEU LEU PRO LYS LEU PRO          
SEQRES  12 I  808  THR LEU PRO LYS ASN TYR SER ASN THR SER LYS ILE PHE          
SEQRES  13 I  808  SER GLU GLU ASN SER ASP GLU ILE ILE LYS LEU LEU GLY          
SEQRES  14 I  808  ASP VAL ARG LEU ASN ILE LEU VAL LEU GLY GLY SER SER          
SEQRES  15 I  808  GLY PHE ILE GLU LEU TYR ALA TYR GLY MET PHE LYS ILE          
SEQRES  16 I  808  ALA ARG VAL THR GLY ILE ALA GLY THR CYS LEU ALA LEU          
SEQRES  17 I  808  CYS LEU SER SER ASP LEU LYS SER LEU SER VAL VAL THR          
SEQRES  18 I  808  GLU VAL SER THR ASN GLY ALA SER GLU VAL SER TYR PHE          
SEQRES  19 I  808  GLN LEU GLU THR ASN LEU LEU TYR SER PHE LEU PRO GLU          
SEQRES  20 I  808  VAL THR ARG MET ALA ARG LYS PHE THR HIS ILE SER ALA          
SEQRES  21 I  808  LEU LEU GLN TYR ILE ASN LEU SER LEU THR CYS MET CYS          
SEQRES  22 I  808  GLU ALA TRP GLU GLU ILE LEU MET GLN MET ASP SER ARG          
SEQRES  23 I  808  LEU THR LYS PHE VAL GLN GLU LYS ASN THR THR THR SER          
SEQRES  24 I  808  VAL GLN ASP GLU PHE MET HIS LEU LEU LEU TRP GLY LYS          
SEQRES  25 I  808  ALA SER ALA GLU LEU GLN THR LEU LEU MET ASN GLN LEU          
SEQRES  26 I  808  THR VAL LYS GLY LEU LYS LYS LEU GLY GLN SER ILE GLU          
SEQRES  27 I  808  SER SER TYR SER SER ILE GLN LYS LEU VAL ILE SER HIS          
SEQRES  28 I  808  LEU GLN SER GLY SER GLU SER LEU LEU TYR HIS LEU SER          
SEQRES  29 I  808  GLU LEU LYS GLY MET ALA SER TRP LYS GLN LYS TYR GLU          
SEQRES  30 I  808  PRO LEU GLY LEU ASP ALA ALA GLY ILE GLU GLU ALA ILE          
SEQRES  31 I  808  THR ALA VAL GLY SER PHE ILE LEU LYS ALA ASN GLU LEU          
SEQRES  32 I  808  LEU GLN VAL ILE ASP SER SER MET LYS ASN PHE LYS ALA          
SEQRES  33 I  808  PHE PHE ARG TRP LEU TYR VAL ALA MET LEU ARG MET THR          
SEQRES  34 I  808  GLU ASP HIS VAL LEU PRO GLU LEU ASN LYS MET THR GLN          
SEQRES  35 I  808  LYS ASP ILE THR PHE VAL ALA GLU PHE LEU THR GLU HIS          
SEQRES  36 I  808  PHE ASN GLU ALA PRO ASP LEU TYR ASN ARG LYS GLY LYS          
SEQRES  37 I  808  TYR PHE ASN VAL GLU ARG VAL GLY GLN TYR LEU LYS ASP          
SEQRES  38 I  808  GLU ASP ASP ASP LEU VAL SER PRO PRO ASN THR GLU GLY          
SEQRES  39 I  808  ASN GLN TRP TYR ASP PHE LEU GLN ASN SER SER HIS LEU          
SEQRES  40 I  808  LYS GLU SER PRO LEU LEU PHE PRO TYR TYR PRO ARG LYS          
SEQRES  41 I  808  SER LEU HIS PHE VAL LYS ARG ARG MET GLU ASN ILE ILE          
SEQRES  42 I  808  ASP GLN CYS LEU GLN LYS PRO ALA ASP VAL ILE GLY LYS          
SEQRES  43 I  808  SER MET ASN GLN ALA ILE CYS ILE PRO LEU TYR ARG ASP          
SEQRES  44 I  808  THR ARG SER GLU ASP SER THR ARG ARG LEU PHE LYS PHE          
SEQRES  45 I  808  PRO PHE LEU TRP ASN ASN LYS THR SER ASN LEU HIS TYR          
SEQRES  46 I  808  LEU LEU PHE THR ILE LEU GLU ASP SER LEU TYR LYS MET          
SEQRES  47 I  808  CYS ILE LEU ARG ARG HIS THR ASP ILE SER GLN SER VAL          
SEQRES  48 I  808  SER ASN GLY LEU ILE ALA ILE LYS PHE GLY SER PHE THR          
SEQRES  49 I  808  TYR ALA THR THR GLU LYS VAL ARG ARG SER ILE TYR SER          
SEQRES  50 I  808  CYS LEU ASP ALA GLN PHE TYR ASP ASP GLU THR VAL THR          
SEQRES  51 I  808  VAL VAL LEU LYS ASP THR VAL GLY ARG GLU GLY ARG ASP          
SEQRES  52 I  808  ARG LEU LEU VAL GLN LEU PRO LEU SER LEU VAL TYR ASN          
SEQRES  53 I  808  SER GLU ASP SER ALA GLU TYR GLN PHE THR GLY THR TYR          
SEQRES  54 I  808  SER THR ARG LEU ASP GLU GLN CYS SER ALA ILE PRO THR          
SEQRES  55 I  808  ARG THR MET HIS PHE GLU LYS HIS TRP ARG LEU LEU GLU          
SEQRES  56 I  808  SER MET LYS ALA GLN TYR VAL ALA GLY ASN GLY PHE ARG          
SEQRES  57 I  808  LYS VAL SER CYS VAL LEU SER SER ASN LEU ARG HIS VAL          
SEQRES  58 I  808  ARG VAL PHE GLU MET ASP ILE ASP ASP GLU TRP GLU LEU          
SEQRES  59 I  808  ASP GLU SER SER ASP GLU GLU GLU GLU ALA SER ASN LYS          
SEQRES  60 I  808  PRO VAL LYS ILE LYS GLU GLU VAL LEU SER GLU SER GLU          
SEQRES  61 I  808  ALA GLU ASN GLN GLN ALA GLY ALA ALA ALA LEU ALA PRO          
SEQRES  62 I  808  GLU ILE VAL ILE LYS VAL GLU LYS LEU ASP PRO GLU LEU          
SEQRES  63 I  808  ASP SER                                                      
SEQRES   1 J  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 J  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 J  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 J  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 J  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 J  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 J  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 J  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 J  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 J  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 J  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 J  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 J  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 J  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 J  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 J  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 J  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 J  620  GLU SER VAL ASP GLY LEU GLN GLU ASN LEU ASP VAL VAL          
SEQRES  19 J  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 J  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 J  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 J  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 J  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 J  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 J  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 J  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 J  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 J  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 J  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 J  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 J  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 J  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 J  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 J  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 J  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 J  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 J  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 J  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 J  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 J  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 J  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 J  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 J  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 J  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 J  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 J  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 J  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 J  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 K  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 K  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 K  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 K  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 K  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 K  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 K  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 K  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 K  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 K  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 K  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 K  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 K  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 K  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 K  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 K  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 K  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 K  620  GLU SER VAL ASP GLY LEU GLN GLU ASN LEU ASP VAL VAL          
SEQRES  19 K  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 K  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 K  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 K  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 K  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 K  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 K  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 K  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 K  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 K  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 K  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 K  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 K  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 K  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 K  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 K  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 K  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 K  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 K  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 K  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 K  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 K  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 K  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 K  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 K  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 K  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 K  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 K  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 K  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 K  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 L  184  MET THR THR PRO ASN LYS THR PRO PRO GLY ALA ASP PRO          
SEQRES   2 L  184  LYS GLN LEU GLU ARG THR GLY THR VAL ARG GLU ILE GLY          
SEQRES   3 L  184  SER GLN ALA VAL TRP SER LEU SER SER CYS LYS PRO GLY          
SEQRES   4 L  184  PHE GLY VAL ASP GLN LEU ARG ASP ASP ASN LEU GLU THR          
SEQRES   5 L  184  TYR TRP GLN SER ASP GLY SER GLN PRO HIS LEU VAL ASN          
SEQRES   6 L  184  ILE GLN PHE ARG ARG LYS THR THR VAL LYS THR LEU CYS          
SEQRES   7 L  184  ILE TYR ALA ASP TYR LYS SER ASP GLU SER TYR THR PRO          
SEQRES   8 L  184  SER LYS ILE SER VAL ARG VAL GLY ASN ASN PHE HIS ASN          
SEQRES   9 L  184  LEU GLN GLU ILE ARG GLN LEU GLU LEU VAL GLU PRO SER          
SEQRES  10 L  184  GLY TRP ILE HIS VAL PRO LEU THR ASP ASN HIS LYS LYS          
SEQRES  11 L  184  PRO THR ARG THR PHE MET ILE GLN ILE ALA VAL LEU ALA          
SEQRES  12 L  184  ASN HIS GLN ASN GLY ARG ASP THR HIS MET ARG GLN ILE          
SEQRES  13 L  184  LYS ILE TYR THR PRO VAL GLU GLU SER SER ILE GLY LYS          
SEQRES  14 L  184  PHE PRO CYS THR THR ILE ASP PHE MET MET TYR ARG SER          
SEQRES  15 L  184  ILE ARG                                                      
SEQRES   1 M   74  MET ASP SER GLU VAL GLN ARG ASP GLY ARG ILE LEU ASP          
SEQRES   2 M   74  LEU ILE ASP ASP ALA TRP ARG GLU ASP LYS LEU PRO TYR          
SEQRES   3 M   74  GLU ASP VAL ALA ILE PRO LEU ASN GLU LEU PRO GLU PRO          
SEQRES   4 M   74  GLU GLN ASP ASN GLY GLY THR THR GLU SER VAL LYS GLU          
SEQRES   5 M   74  GLN GLU MET LYS TRP THR ASP LEU ALA LEU GLN TYR LEU          
SEQRES   6 M   74  HIS GLU ASN VAL PRO PRO ILE GLY ASN                          
SEQRES   1 N  822  MET ALA ALA ALA VAL VAL VAL ALA GLU GLY ASP SER ASP          
SEQRES   2 N  822  SER ARG PRO GLY GLN GLU LEU LEU VAL ALA TRP ASN THR          
SEQRES   3 N  822  VAL SER THR GLY LEU VAL PRO PRO ALA ALA LEU GLY LEU          
SEQRES   4 N  822  VAL SER SER ARG THR SER GLY ALA VAL PRO PRO LYS GLU          
SEQRES   5 N  822  GLU GLU LEU ARG ALA ALA VAL GLU VAL LEU ARG GLY HIS          
SEQRES   6 N  822  GLY LEU HIS SER VAL LEU GLU GLU TRP PHE VAL GLU VAL          
SEQRES   7 N  822  LEU GLN ASN ASP LEU GLN ALA ASN ILE SER PRO GLU PHE          
SEQRES   8 N  822  TRP ASN ALA ILE SER GLN CYS GLU ASN SER ALA ASP GLU          
SEQRES   9 N  822  PRO GLN CYS LEU LEU LEU LEU LEU ASP ALA PHE GLY LEU          
SEQRES  10 N  822  LEU GLU SER ARG LEU ASP PRO TYR LEU ARG SER LEU GLU          
SEQRES  11 N  822  LEU LEU GLU LYS TRP THR ARG LEU GLY LEU LEU MET GLY          
SEQRES  12 N  822  THR GLY ALA GLN GLY LEU ARG GLU GLU VAL HIS THR MET          
SEQRES  13 N  822  LEU ARG GLY VAL LEU PHE PHE SER THR PRO ARG THR PHE          
SEQRES  14 N  822  GLN GLU MET ILE GLN ARG LEU TYR GLY CYS PHE LEU ARG          
SEQRES  15 N  822  VAL TYR MET GLN SER LYS ARG LYS GLY GLU GLY GLY THR          
SEQRES  16 N  822  ASP PRO GLU LEU GLU GLY GLU LEU ASP SER ARG TYR ALA          
SEQRES  17 N  822  ARG ARG ARG TYR TYR ARG LEU LEU GLN SER PRO LEU CYS          
SEQRES  18 N  822  ALA GLY CYS SER SER ASP LYS GLN GLN CYS TRP CYS ARG          
SEQRES  19 N  822  GLN ALA LEU GLU GLN PHE HIS GLN LEU SER GLN VAL LEU          
SEQRES  20 N  822  HIS ARG LEU SER LEU LEU GLU ARG VAL SER ALA GLU ALA          
SEQRES  21 N  822  VAL THR THR THR LEU HIS GLN VAL THR ARG GLU ARG MET          
SEQRES  22 N  822  GLU ASP ARG CYS ARG GLY GLU TYR GLU ARG SER PHE LEU          
SEQRES  23 N  822  ARG GLU PHE HIS LYS TRP ILE GLU ARG VAL VAL GLY TRP          
SEQRES  24 N  822  LEU GLY LYS VAL PHE LEU GLN ASP GLY PRO ALA ARG PRO          
SEQRES  25 N  822  ALA SER PRO GLU ALA GLY ASN THR LEU ARG ARG TRP ARG          
SEQRES  26 N  822  CYS HIS VAL GLN ARG PHE PHE TYR ARG ILE TYR ALA SER          
SEQRES  27 N  822  LEU ARG ILE GLU GLU LEU PHE SER ILE VAL ARG ASP PHE          
SEQRES  28 N  822  PRO ASP SER ARG PRO ALA ILE GLU ASP LEU LYS TYR CYS          
SEQRES  29 N  822  LEU GLU ARG THR ASP GLN ARG GLN GLN LEU LEU VAL SER          
SEQRES  30 N  822  LEU LYS ALA ALA LEU GLU THR ARG LEU LEU HIS PRO GLY          
SEQRES  31 N  822  VAL ASN THR CYS ASP ILE ILE THR LEU TYR ILE SER ALA          
SEQRES  32 N  822  ILE LYS ALA LEU ARG VAL LEU ASP PRO SER MET VAL ILE          
SEQRES  33 N  822  LEU GLU VAL ALA CYS GLU PRO ILE ARG ARG TYR LEU ARG          
SEQRES  34 N  822  THR ARG GLU ASP THR VAL ARG GLN ILE VAL ALA GLY LEU          
SEQRES  35 N  822  THR GLY ASP SER ASP GLY THR GLY ASP LEU ALA VAL GLU          
SEQRES  36 N  822  LEU SER LYS THR ASP PRO ALA SER LEU GLU THR GLY GLN          
SEQRES  37 N  822  ASP SER GLU ASP ASP SER GLY GLU PRO GLU ASP TRP VAL          
SEQRES  38 N  822  PRO ASP PRO VAL ASP ALA ASP PRO GLY LYS SER SER SER          
SEQRES  39 N  822  LYS ARG ARG SER SER ASP ILE ILE SER LEU LEU VAL SER          
SEQRES  40 N  822  ILE TYR GLY SER LYS ASP LEU PHE ILE ASN GLU TYR ARG          
SEQRES  41 N  822  SER LEU LEU ALA ASP ARG LEU LEU HIS GLN PHE SER PHE          
SEQRES  42 N  822  SER PRO GLU ARG GLU ILE ARG ASN VAL GLU LEU LEU LYS          
SEQRES  43 N  822  LEU ARG PHE GLY GLU ALA PRO MET HIS PHE CYS GLU VAL          
SEQRES  44 N  822  MET LEU LYS ASP MET ALA ASP SER ARG ARG ILE ASN ALA          
SEQRES  45 N  822  ASN ILE ARG GLU GLU ASP GLU LYS ARG PRO ALA GLU GLU          
SEQRES  46 N  822  GLN PRO PRO PHE GLY VAL TYR ALA VAL ILE LEU SER SER          
SEQRES  47 N  822  GLU PHE TRP PRO PRO PHE LYS ASP GLU LYS LEU GLU VAL          
SEQRES  48 N  822  PRO GLU ASP ILE ARG ALA ALA LEU GLU ALA TYR CYS LYS          
SEQRES  49 N  822  LYS TYR GLU GLN LEU LYS ALA MET ARG THR LEU SER TRP          
SEQRES  50 N  822  LYS HIS THR LEU GLY LEU VAL THR MET ASP VAL GLU LEU          
SEQRES  51 N  822  ALA ASP ARG THR LEU SER VAL ALA VAL THR PRO VAL GLN          
SEQRES  52 N  822  ALA VAL ILE LEU LEU TYR PHE GLN ASP GLN ALA SER TRP          
SEQRES  53 N  822  THR LEU GLU GLU LEU SER LYS ALA VAL LYS MET PRO VAL          
SEQRES  54 N  822  ALA LEU LEU ARG ARG ARG MET SER VAL TRP LEU GLN GLN          
SEQRES  55 N  822  GLY VAL LEU ARG GLU GLU PRO PRO GLY THR PHE SER VAL          
SEQRES  56 N  822  ILE GLU GLU GLU ARG PRO GLN ASP ARG ASP ASN MET VAL          
SEQRES  57 N  822  LEU ILE ASP SER ASP ASP GLU SER ASP SER GLY MET ALA          
SEQRES  58 N  822  SER GLN ALA ASP GLN LYS GLU GLU GLU LEU LEU LEU PHE          
SEQRES  59 N  822  TRP THR TYR ILE GLN ALA MET LEU THR ASN LEU GLU SER          
SEQRES  60 N  822  LEU SER LEU ASP ARG ILE TYR ASN MET LEU ARG MET PHE          
SEQRES  61 N  822  VAL VAL THR GLY PRO ALA LEU ALA GLU ILE ASP LEU GLN          
SEQRES  62 N  822  GLU LEU GLN GLY TYR LEU GLN LYS LYS VAL ARG ASP GLN          
SEQRES  63 N  822  GLN LEU VAL TYR SER ALA GLY VAL TYR ARG LEU PRO LYS          
SEQRES  64 N  822  ASN CYS SER                                                  
SEQRES   1 O  755  MET ALA SER VAL HIS GLU SER LEU TYR PHE ASN PRO MET          
SEQRES   2 O  755  MET THR ASN GLY VAL VAL HIS ALA ASN VAL PHE GLY ILE          
SEQRES   3 O  755  LYS ASP TRP VAL THR PRO TYR LYS ILE ALA VAL LEU VAL          
SEQRES   4 O  755  LEU LEU ASN GLU MET SER ARG THR GLY GLU GLY ALA VAL          
SEQRES   5 O  755  SER LEU MET GLU ARG ARG ARG LEU ASN GLN LEU LEU LEU          
SEQRES   6 O  755  PRO LEU LEU GLN GLY PRO ASP ILE THR LEU SER LYS LEU          
SEQRES   7 O  755  TYR LYS LEU ILE GLU GLU SER CYS PRO GLN LEU ALA ASN          
SEQRES   8 O  755  SER VAL GLN ILE ARG ILE LYS LEU MET ALA GLU GLY GLU          
SEQRES   9 O  755  LEU LYS ASP MET GLU GLN PHE PHE ASP ASP LEU SER ASP          
SEQRES  10 O  755  SER PHE SER GLY THR GLU PRO GLU VAL HIS LYS THR SER          
SEQRES  11 O  755  VAL VAL GLY LEU PHE LEU ARG HIS MET ILE LEU ALA TYR          
SEQRES  12 O  755  SER LYS LEU SER PHE SER GLN VAL PHE LYS LEU TYR THR          
SEQRES  13 O  755  ALA LEU GLN GLN TYR PHE GLN ASN GLY GLU LYS LYS THR          
SEQRES  14 O  755  VAL GLU ASP ALA ASP MET GLU LEU THR SER ARG ASP GLU          
SEQRES  15 O  755  GLY GLU ARG LYS MET GLU LYS GLU GLU LEU ASP VAL SER          
SEQRES  16 O  755  VAL ARG GLU GLU GLU VAL SER CYS SER GLY PRO LEU SER          
SEQRES  17 O  755  GLN LYS GLN ALA GLU PHE PHE LEU SER GLN GLN ALA SER          
SEQRES  18 O  755  LEU LEU LYS ASN ASP GLU THR LYS ALA LEU THR PRO ALA          
SEQRES  19 O  755  SER LEU GLN LYS GLU LEU ASN ASN LEU LEU LYS PHE ASN          
SEQRES  20 O  755  PRO ASP PHE ALA GLU ALA HIS TYR LEU SER TYR LEU ASN          
SEQRES  21 O  755  ASN LEU ARG VAL GLN ASP VAL PHE SER SER THR HIS SER          
SEQRES  22 O  755  LEU LEU HIS TYR PHE ASP ARG LEU ILE LEU THR GLY ALA          
SEQRES  23 O  755  GLU SER LYS SER ASN GLY GLU GLU GLY TYR GLY ARG SER          
SEQRES  24 O  755  LEU ARG TYR ALA ALA LEU ASN LEU ALA ALA LEU HIS CYS          
SEQRES  25 O  755  ARG PHE GLY HIS TYR GLN GLN ALA GLU LEU ALA LEU GLN          
SEQRES  26 O  755  GLU ALA ILE ARG ILE ALA GLN GLU SER ASN ASP HIS VAL          
SEQRES  27 O  755  CYS LEU GLN HIS CYS LEU SER TRP LEU TYR VAL LEU GLY          
SEQRES  28 O  755  GLN LYS ARG SER ASP SER TYR VAL LEU LEU GLU HIS SER          
SEQRES  29 O  755  VAL LYS LYS ALA VAL HIS PHE GLY LEU PRO TYR LEU ALA          
SEQRES  30 O  755  SER LEU GLY ILE GLN SER LEU VAL GLN GLN ARG ALA PHE          
SEQRES  31 O  755  ALA GLY LYS THR ALA ASN LYS LEU MET ASP ALA LEU LYS          
SEQRES  32 O  755  ASP SER ASP LEU LEU HIS TRP LYS HIS SER LEU SER GLU          
SEQRES  33 O  755  LEU ILE ASP ILE SER ILE ALA GLN LYS THR ALA ILE TRP          
SEQRES  34 O  755  ARG LEU TYR GLY ARG SER THR MET ALA LEU GLN GLN ALA          
SEQRES  35 O  755  GLN MET LEU LEU SER MET ASN SER LEU GLU ALA VAL ASN          
SEQRES  36 O  755  ALA GLY VAL GLN GLN ASN ASN THR GLU SER PHE ALA VAL          
SEQRES  37 O  755  ALA LEU CYS HIS LEU ALA GLU LEU HIS ALA GLU GLN GLY          
SEQRES  38 O  755  CYS PHE ALA ALA ALA SER GLU VAL LEU LYS HIS LEU LYS          
SEQRES  39 O  755  GLU ARG PHE PRO PRO ASN SER GLN HIS ALA GLN LEU TRP          
SEQRES  40 O  755  MET LEU CYS ASP GLN LYS ILE GLN PHE ASP ARG ALA MET          
SEQRES  41 O  755  ASN ASP GLY LYS TYR HIS LEU ALA ASP SER LEU VAL THR          
SEQRES  42 O  755  GLY ILE THR ALA LEU ASN SER ILE GLU GLY VAL TYR ARG          
SEQRES  43 O  755  LYS ALA VAL VAL LEU GLN ALA GLN ASN GLN MET SER GLU          
SEQRES  44 O  755  ALA HIS LYS LEU LEU GLN LYS LEU LEU VAL HIS CYS GLN          
SEQRES  45 O  755  LYS LEU LYS ASN THR GLU MET VAL ILE SER VAL LEU LEU          
SEQRES  46 O  755  SER VAL ALA GLU LEU TYR TRP ARG SER SER SER PRO THR          
SEQRES  47 O  755  ILE ALA LEU PRO MET LEU LEU GLN ALA LEU ALA LEU SER          
SEQRES  48 O  755  LYS GLU TYR ARG LEU GLN TYR LEU ALA SER GLU THR VAL          
SEQRES  49 O  755  LEU ASN LEU ALA PHE ALA GLN LEU ILE LEU GLY ILE PRO          
SEQRES  50 O  755  GLU GLN ALA LEU SER LEU LEU HIS MET ALA ILE GLU PRO          
SEQRES  51 O  755  ILE LEU ALA ASP GLY ALA ILE LEU ASP LYS GLY ARG ALA          
SEQRES  52 O  755  MET PHE LEU VAL ALA LYS CYS GLN VAL ALA SER ALA ALA          
SEQRES  53 O  755  SER TYR ASP GLN PRO LYS LYS ALA GLU ALA LEU GLU ALA          
SEQRES  54 O  755  ALA ILE GLU ASN LEU ASN GLU ALA LYS ASN TYR PHE ALA          
SEQRES  55 O  755  LYS VAL ASP CYS LYS GLU ARG ILE ARG ASP VAL VAL TYR          
SEQRES  56 O  755  PHE GLN ALA ARG LEU TYR HIS THR LEU GLY LYS THR GLN          
SEQRES  57 O  755  GLU ARG ASN ARG CYS ALA MET LEU PHE ARG GLN LEU HIS          
SEQRES  58 O  755  GLN GLU LEU PRO SER HIS GLY VAL PRO LEU ILE ASN HIS          
SEQRES  59 O  755  LEU                                                          
SEQRES   1 P  597  MET ALA ALA SER THR SER MET VAL PRO VAL ALA VAL THR          
SEQRES   2 P  597  ALA ALA VAL ALA PRO VAL LEU SER ILE ASN SER ASP PHE          
SEQRES   3 P  597  SER ASP LEU ARG GLU ILE LYS LYS GLN LEU LEU LEU ILE          
SEQRES   4 P  597  ALA GLY LEU THR ARG GLU ARG GLY LEU LEU HIS SER SER          
SEQRES   5 P  597  LYS TRP SER ALA GLU LEU ALA PHE SER LEU PRO ALA LEU          
SEQRES   6 P  597  PRO LEU ALA GLU LEU GLN PRO PRO PRO PRO ILE THR GLU          
SEQRES   7 P  597  GLU ASP ALA GLN ASP MET ASP ALA TYR THR LEU ALA LYS          
SEQRES   8 P  597  ALA TYR PHE ASP VAL LYS GLU TYR ASP ARG ALA ALA HIS          
SEQRES   9 P  597  PHE LEU HIS GLY CYS ASN SER LYS LYS ALA TYR PHE LEU          
SEQRES  10 P  597  TYR MET TYR SER ARG TYR LEU SER GLY GLU LYS LYS LYS          
SEQRES  11 P  597  ASP ASP GLU THR VAL ASP SER LEU GLY PRO LEU GLU LYS          
SEQRES  12 P  597  GLY GLN VAL LYS ASN GLU ALA LEU ARG GLU LEU ARG VAL          
SEQRES  13 P  597  GLU LEU SER LYS LYS HIS GLN ALA ARG GLU LEU ASP GLY          
SEQRES  14 P  597  PHE GLY LEU TYR LEU TYR GLY VAL VAL LEU ARG LYS LEU          
SEQRES  15 P  597  ASP LEU VAL LYS GLU ALA ILE ASP VAL PHE VAL GLU ALA          
SEQRES  16 P  597  THR HIS VAL LEU PRO LEU HIS TRP GLY ALA TRP LEU GLU          
SEQRES  17 P  597  LEU CYS ASN LEU ILE THR ASP LYS GLU MET LEU LYS PHE          
SEQRES  18 P  597  LEU SER LEU PRO ASP THR TRP MET LYS GLU PHE PHE LEU          
SEQRES  19 P  597  ALA HIS ILE TYR THR GLU LEU GLN LEU ILE GLU GLU ALA          
SEQRES  20 P  597  LEU GLN LYS TYR GLN ASN LEU ILE ASP VAL GLY PHE SER          
SEQRES  21 P  597  LYS SER SER TYR ILE VAL SER GLN ILE ALA VAL ALA TYR          
SEQRES  22 P  597  HIS ASN ILE ARG ASP ILE ASP LYS ALA LEU SER ILE PHE          
SEQRES  23 P  597  ASN GLU LEU ARG LYS GLN ASP PRO TYR ARG ILE GLU ASN          
SEQRES  24 P  597  MET ASP THR PHE SER ASN LEU LEU TYR VAL ARG SER MET          
SEQRES  25 P  597  LYS SER GLU LEU SER TYR LEU ALA HIS ASN LEU CYS GLU          
SEQRES  26 P  597  ILE ASP LYS TYR ARG VAL GLU THR CYS CYS VAL ILE GLY          
SEQRES  27 P  597  ASN TYR TYR SER LEU ARG SER GLN HIS GLU LYS ALA ALA          
SEQRES  28 P  597  LEU TYR PHE GLN ARG ALA LEU LYS LEU ASN PRO ARG TYR          
SEQRES  29 P  597  LEU GLY ALA TRP THR LEU MET GLY HIS GLU TYR MET GLU          
SEQRES  30 P  597  MET LYS ASN THR SER ALA ALA ILE GLN ALA TYR ARG HIS          
SEQRES  31 P  597  ALA ILE GLU VAL ASN LYS ARG ASP TYR ARG ALA TRP TYR          
SEQRES  32 P  597  GLY LEU GLY GLN THR TYR GLU ILE LEU LYS MET PRO PHE          
SEQRES  33 P  597  TYR CYS LEU TYR TYR TYR ARG ARG ALA HIS GLN LEU ARG          
SEQRES  34 P  597  PRO ASN ASP SER ARG MET LEU VAL ALA LEU GLY GLU CYS          
SEQRES  35 P  597  TYR GLU LYS LEU ASN GLN LEU VAL GLU ALA LYS LYS CYS          
SEQRES  36 P  597  TYR TRP ARG ALA TYR ALA VAL GLY ASP VAL GLU LYS MET          
SEQRES  37 P  597  ALA LEU VAL LYS LEU ALA LYS LEU HIS GLU GLN LEU THR          
SEQRES  38 P  597  GLU SER GLU GLN ALA ALA GLN CYS TYR ILE LYS TYR ILE          
SEQRES  39 P  597  GLN ASP ILE TYR SER CYS GLY GLU ILE VAL GLU HIS LEU          
SEQRES  40 P  597  GLU GLU SER THR ALA PHE ARG TYR LEU ALA GLN TYR TYR          
SEQRES  41 P  597  PHE LYS CYS LYS LEU TRP ASP GLU ALA SER THR CYS ALA          
SEQRES  42 P  597  GLN LYS CYS CYS ALA PHE ASN ASP THR ARG GLU GLU GLY          
SEQRES  43 P  597  LYS ALA LEU LEU ARG GLN ILE LEU GLN LEU ARG ASN GLN          
SEQRES  44 P  597  GLY GLU THR PRO THR THR GLU VAL PRO ALA PRO PHE PHE          
SEQRES  45 P  597  LEU PRO ALA SER LEU SER ALA ASN ASN THR PRO THR ARG          
SEQRES  46 P  597  ARG VAL SER PRO LEU ASN LEU SER SER VAL THR PRO              
SEQRES   1 R  499  MET ALA GLN PHE ALA PHE GLU SER ASP LEU HIS SER LEU          
SEQRES   2 R  499  LEU GLN LEU ASP ALA PRO ILE PRO ASN ALA PRO PRO ALA          
SEQRES   3 R  499  ARG TRP GLN ARG LYS ALA LYS GLU ALA ALA GLY PRO ALA          
SEQRES   4 R  499  PRO SER PRO MET ARG ALA ALA ASN ARG SER HIS SER ALA          
SEQRES   5 R  499  GLY ARG THR PRO GLY ARG THR PRO GLY LYS SER SER SER          
SEQRES   6 R  499  LYS VAL GLN THR THR PRO SER LYS PRO GLY GLY ASP ARG          
SEQRES   7 R  499  TYR ILE PRO HIS ARG SER ALA ALA GLN MET GLU VAL ALA          
SEQRES   8 R  499  SER PHE LEU LEU SER LYS GLU ASN GLN PRO GLU ASN SER          
SEQRES   9 R  499  GLN THR PRO THR LYS LYS GLU HIS GLN LYS ALA TRP ALA          
SEQRES  10 R  499  LEU ASN LEU ASN GLY PHE ASP VAL GLU GLU ALA LYS ILE          
SEQRES  11 R  499  LEU ARG LEU SER GLY LYS PRO GLN ASN ALA PRO GLU GLY          
SEQRES  12 R  499  TYR GLN ASN ARG LEU LYS VAL LEU TYR SER GLN LYS ALA          
SEQRES  13 R  499  THR PRO GLY SER SER ARG LYS THR CYS ARG TYR ILE PRO          
SEQRES  14 R  499  SER LEU PRO ASP ARG ILE LEU ASP ALA PRO GLU ILE ARG          
SEQRES  15 R  499  ASN ASP TYR TYR LEU ASN LEU VAL ASP TRP SER SER GLY          
SEQRES  16 R  499  ASN VAL LEU ALA VAL ALA LEU ASP ASN SER VAL TYR LEU          
SEQRES  17 R  499  TRP SER ALA SER SER GLY ASP ILE LEU GLN LEU LEU GLN          
SEQRES  18 R  499  MET GLU GLN PRO GLY GLU TYR ILE SER SER VAL ALA TRP          
SEQRES  19 R  499  ILE LYS GLU GLY ASN TYR LEU ALA VAL GLY THR SER SER          
SEQRES  20 R  499  ALA GLU VAL GLN LEU TRP ASP VAL GLN GLN GLN LYS ARG          
SEQRES  21 R  499  LEU ARG ASN MET THR SER HIS SER ALA ARG VAL GLY SER          
SEQRES  22 R  499  LEU SER TRP ASN SER TYR ILE LEU SER SER GLY SER ARG          
SEQRES  23 R  499  SER GLY HIS ILE HIS HIS HIS ASP VAL ARG VAL ALA GLU          
SEQRES  24 R  499  HIS HIS VAL ALA THR LEU SER GLY HIS SER GLN GLU VAL          
SEQRES  25 R  499  CYS GLY LEU ARG TRP ALA PRO ASP GLY ARG HIS LEU ALA          
SEQRES  26 R  499  SER GLY GLY ASN ASP ASN LEU VAL ASN VAL TRP PRO SER          
SEQRES  27 R  499  ALA PRO GLY GLU GLY GLY TRP VAL PRO LEU GLN THR PHE          
SEQRES  28 R  499  THR GLN HIS GLN GLY ALA VAL LYS ALA VAL ALA TRP CYS          
SEQRES  29 R  499  PRO TRP GLN SER ASN VAL LEU ALA THR GLY GLY GLY THR          
SEQRES  30 R  499  SER ASP ARG HIS ILE ARG ILE TRP ASN VAL CYS SER GLY          
SEQRES  31 R  499  ALA CYS LEU SER ALA VAL ASP ALA HIS SER GLN VAL CYS          
SEQRES  32 R  499  SER ILE LEU TRP SER PRO HIS TYR LYS GLU LEU ILE SER          
SEQRES  33 R  499  GLY HIS GLY PHE ALA GLN ASN GLN LEU VAL ILE TRP LYS          
SEQRES  34 R  499  TYR PRO THR MET ALA LYS VAL ALA GLU LEU LYS GLY HIS          
SEQRES  35 R  499  THR SER ARG VAL LEU SER LEU THR MET SER PRO ASP GLY          
SEQRES  36 R  499  ALA THR VAL ALA SER ALA ALA ALA ASP GLU THR LEU ARG          
SEQRES  37 R  499  LEU TRP ARG CYS PHE GLU LEU ASP PRO ALA ARG ARG ARG          
SEQRES  38 R  499  GLU ARG GLU LYS ALA SER ALA ALA LYS SER SER LEU ILE          
SEQRES  39 R  499  HIS GLN GLY ILE ARG                                          
SEQRES   1 S  206  GLN ASN SER ALA SER LYS ARG SER LEU TYR SER LEU GLN          
SEQRES   2 S  206  SER ILE SER LYS ARG SER LEU ASN LEU ASN ASP LEU LEU          
SEQRES   3 S  206  VAL PHE ASP ASP PRO LEU PRO SER LYS LYS PRO ALA SER          
SEQRES   4 S  206  GLU ASN VAL ASN LYS SER GLU PRO HIS SER LEU GLU SER          
SEQRES   5 S  206  ASP SER ASP PHE GLU ILE LEU CYS ASP GLN ILE LEU PHE          
SEQRES   6 S  206  GLY ASN ALA LEU ASP ARG ILE LEU GLU GLU GLU GLU ASP          
SEQRES   7 S  206  ASN GLU LYS GLU ARG ASP THR GLN ARG GLN ARG GLN ASN          
SEQRES   8 S  206  ASP THR LYS SER SER ALA ASP THR PHE THR ILE SER GLY          
SEQRES   9 S  206  VAL SER THR ASN LYS GLU ASN GLU GLY PRO GLU TYR PRO          
SEQRES  10 S  206  THR LYS ILE GLU LYS ASN GLN PHE ASN MET SER TYR LYS          
SEQRES  11 S  206  PRO SER GLU ASN MET SER GLY LEU SER SER PHE PRO ILE          
SEQRES  12 S  206  PHE GLU LYS GLU ASN THR LEU SER SER SER TYR LEU GLU          
SEQRES  13 S  206  GLU GLN LYS PRO LYS ARG ALA ALA LEU SER ASP ILE THR          
SEQRES  14 S  206  ASN SER PHE ASN LYS MET ASN LYS GLN GLU GLY MET ARG          
SEQRES  15 S  206  ILE GLU LYS LYS ILE GLN ARG GLU GLN LEU GLN LYS LYS          
SEQRES  16 S  206  ASN ASP ARG PRO SER PRO LEU LYS PRO ILE GLN                  
SEQRES   1 W   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 W   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 W   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 W   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 W   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 W   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 W   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 X  599  MET ASP PRO GLY ASP ALA ALA ILE LEU GLU SER SER LEU          
SEQRES   2 X  599  ARG ILE LEU TYR ARG LEU PHE GLU SER VAL LEU PRO PRO          
SEQRES   3 X  599  LEU PRO ALA ALA LEU GLN SER ARG MET ASN VAL ILE ASP          
SEQRES   4 X  599  HIS VAL ARG ASP MET ALA ALA ALA GLY LEU HIS SER ASN          
SEQRES   5 X  599  VAL ARG LEU LEU SER SER LEU LEU LEU THR MET SER ASN          
SEQRES   6 X  599  ASN ASN PRO GLU LEU PHE SER PRO PRO GLN LYS TYR GLN          
SEQRES   7 X  599  LEU LEU VAL TYR HIS ALA ASP SER LEU PHE HIS ASP LYS          
SEQRES   8 X  599  GLU TYR ARG ASN ALA VAL SER LYS TYR THR MET ALA LEU          
SEQRES   9 X  599  GLN GLN LYS LYS ALA LEU SER LYS THR SER LYS VAL ARG          
SEQRES  10 X  599  PRO SER THR GLY ASN SER ALA SER THR PRO GLN SER GLN          
SEQRES  11 X  599  CYS LEU PRO SER GLU ILE GLU VAL LYS TYR LYS MET ALA          
SEQRES  12 X  599  GLU CYS TYR THR MET LEU LYS GLN ASP LYS ASP ALA ILE          
SEQRES  13 X  599  ALA ILE LEU ASP GLY ILE PRO SER ARG GLN ARG THR PRO          
SEQRES  14 X  599  LYS ILE ASN MET MET LEU ALA ASN LEU TYR LYS LYS ALA          
SEQRES  15 X  599  GLY GLN GLU ARG PRO SER VAL THR SER TYR LYS GLU VAL          
SEQRES  16 X  599  LEU ARG GLN CYS PRO LEU ALA LEU ASP ALA ILE LEU GLY          
SEQRES  17 X  599  LEU LEU SER LEU SER VAL LYS GLY ALA GLU VAL ALA SER          
SEQRES  18 X  599  MET THR MET ASN VAL ILE GLN THR VAL PRO ASN LEU ASP          
SEQRES  19 X  599  TRP LEU SER VAL TRP ILE LYS ALA TYR ALA PHE VAL HIS          
SEQRES  20 X  599  THR GLY ASP ASN SER ARG ALA ILE SER THR ILE CYS SER          
SEQRES  21 X  599  LEU GLU LYS LYS SER LEU LEU ARG ASP ASN VAL ASP LEU          
SEQRES  22 X  599  LEU GLY SER LEU ALA ASP LEU TYR PHE ARG ALA GLY ASP          
SEQRES  23 X  599  ASN LYS ASN SER VAL LEU LYS PHE GLU GLN ALA GLN MET          
SEQRES  24 X  599  LEU ASP PRO TYR LEU ILE LYS GLY MET ASP VAL TYR GLY          
SEQRES  25 X  599  TYR LEU LEU ALA ARG GLU GLY ARG LEU GLU ASP VAL GLU          
SEQRES  26 X  599  ASN LEU GLY CYS ARG LEU PHE ASN ILE SER ASP GLN HIS          
SEQRES  27 X  599  ALA GLU PRO TRP VAL VAL SER GLY CYS HIS SER PHE TYR          
SEQRES  28 X  599  SER LYS ARG TYR SER ARG ALA LEU TYR LEU GLY ALA LYS          
SEQRES  29 X  599  ALA ILE GLN LEU ASN SER ASN SER VAL GLN ALA LEU LEU          
SEQRES  30 X  599  LEU LYS GLY ALA ALA LEU ARG ASN MET GLY ARG VAL GLN          
SEQRES  31 X  599  GLU ALA ILE ILE HIS PHE ARG GLU ALA ILE ARG LEU ALA          
SEQRES  32 X  599  PRO CYS ARG LEU ASP CYS TYR GLU GLY LEU ILE GLU CYS          
SEQRES  33 X  599  TYR LEU ALA SER ASN SER ILE ARG GLU ALA MET VAL MET          
SEQRES  34 X  599  ALA ASN ASN VAL TYR LYS THR LEU GLY ALA ASN ALA GLN          
SEQRES  35 X  599  THR LEU THR LEU LEU ALA THR VAL CYS LEU GLU ASP PRO          
SEQRES  36 X  599  VAL THR GLN GLU LYS ALA LYS THR LEU LEU ASP LYS ALA          
SEQRES  37 X  599  LEU THR GLN ARG PRO ASP TYR ILE LYS ALA VAL VAL LYS          
SEQRES  38 X  599  LYS ALA GLU LEU LEU SER ARG GLU GLN LYS TYR GLU ASP          
SEQRES  39 X  599  GLY ILE ALA LEU LEU ARG ASN ALA LEU ALA ASN GLN SER          
SEQRES  40 X  599  ASP CYS VAL LEU HIS ARG ILE LEU GLY ASP PHE LEU VAL          
SEQRES  41 X  599  ALA VAL ASN GLU TYR GLN GLU ALA MET ASP GLN TYR SER          
SEQRES  42 X  599  ILE ALA LEU SER LEU ASP PRO ASN ASP GLN LYS SER LEU          
SEQRES  43 X  599  GLU GLY MET GLN LYS MET GLU LYS GLU GLU SER PRO THR          
SEQRES  44 X  599  ASP ALA THR GLN GLU GLU ASP VAL ASP ASP MET GLU GLY          
SEQRES  45 X  599  SER GLY GLU GLU GLY ASP LEU GLU GLY SER ASP SER GLU          
SEQRES  46 X  599  ALA ALA GLN TRP ALA ASP GLN GLU GLN TRP PHE GLY MET          
SEQRES  47 X  599  GLN                                                          
SEQRES   1 Y  599  MET ASP PRO GLY ASP ALA ALA ILE LEU GLU SER SER LEU          
SEQRES   2 Y  599  ARG ILE LEU TYR ARG LEU PHE GLU SER VAL LEU PRO PRO          
SEQRES   3 Y  599  LEU PRO ALA ALA LEU GLN SER ARG MET ASN VAL ILE ASP          
SEQRES   4 Y  599  HIS VAL ARG ASP MET ALA ALA ALA GLY LEU HIS SER ASN          
SEQRES   5 Y  599  VAL ARG LEU LEU SER SER LEU LEU LEU THR MET SER ASN          
SEQRES   6 Y  599  ASN ASN PRO GLU LEU PHE SER PRO PRO GLN LYS TYR GLN          
SEQRES   7 Y  599  LEU LEU VAL TYR HIS ALA ASP SER LEU PHE HIS ASP LYS          
SEQRES   8 Y  599  GLU TYR ARG ASN ALA VAL SER LYS TYR THR MET ALA LEU          
SEQRES   9 Y  599  GLN GLN LYS LYS ALA LEU SER LYS THR SER LYS VAL ARG          
SEQRES  10 Y  599  PRO SER THR GLY ASN SER ALA SER THR PRO GLN SER GLN          
SEQRES  11 Y  599  CYS LEU PRO SER GLU ILE GLU VAL LYS TYR LYS MET ALA          
SEQRES  12 Y  599  GLU CYS TYR THR MET LEU LYS GLN ASP LYS ASP ALA ILE          
SEQRES  13 Y  599  ALA ILE LEU ASP GLY ILE PRO SER ARG GLN ARG THR PRO          
SEQRES  14 Y  599  LYS ILE ASN MET MET LEU ALA ASN LEU TYR LYS LYS ALA          
SEQRES  15 Y  599  GLY GLN GLU ARG PRO SER VAL THR SER TYR LYS GLU VAL          
SEQRES  16 Y  599  LEU ARG GLN CYS PRO LEU ALA LEU ASP ALA ILE LEU GLY          
SEQRES  17 Y  599  LEU LEU SER LEU SER VAL LYS GLY ALA GLU VAL ALA SER          
SEQRES  18 Y  599  MET THR MET ASN VAL ILE GLN THR VAL PRO ASN LEU ASP          
SEQRES  19 Y  599  TRP LEU SER VAL TRP ILE LYS ALA TYR ALA PHE VAL HIS          
SEQRES  20 Y  599  THR GLY ASP ASN SER ARG ALA ILE SER THR ILE CYS SER          
SEQRES  21 Y  599  LEU GLU LYS LYS SER LEU LEU ARG ASP ASN VAL ASP LEU          
SEQRES  22 Y  599  LEU GLY SER LEU ALA ASP LEU TYR PHE ARG ALA GLY ASP          
SEQRES  23 Y  599  ASN LYS ASN SER VAL LEU LYS PHE GLU GLN ALA GLN MET          
SEQRES  24 Y  599  LEU ASP PRO TYR LEU ILE LYS GLY MET ASP VAL TYR GLY          
SEQRES  25 Y  599  TYR LEU LEU ALA ARG GLU GLY ARG LEU GLU ASP VAL GLU          
SEQRES  26 Y  599  ASN LEU GLY CYS ARG LEU PHE ASN ILE SER ASP GLN HIS          
SEQRES  27 Y  599  ALA GLU PRO TRP VAL VAL SER GLY CYS HIS SER PHE TYR          
SEQRES  28 Y  599  SER LYS ARG TYR SER ARG ALA LEU TYR LEU GLY ALA LYS          
SEQRES  29 Y  599  ALA ILE GLN LEU ASN SER ASN SER VAL GLN ALA LEU LEU          
SEQRES  30 Y  599  LEU LYS GLY ALA ALA LEU ARG ASN MET GLY ARG VAL GLN          
SEQRES  31 Y  599  GLU ALA ILE ILE HIS PHE ARG GLU ALA ILE ARG LEU ALA          
SEQRES  32 Y  599  PRO CYS ARG LEU ASP CYS TYR GLU GLY LEU ILE GLU CYS          
SEQRES  33 Y  599  TYR LEU ALA SER ASN SER ILE ARG GLU ALA MET VAL MET          
SEQRES  34 Y  599  ALA ASN ASN VAL TYR LYS THR LEU GLY ALA ASN ALA GLN          
SEQRES  35 Y  599  THR LEU THR LEU LEU ALA THR VAL CYS LEU GLU ASP PRO          
SEQRES  36 Y  599  VAL THR GLN GLU LYS ALA LYS THR LEU LEU ASP LYS ALA          
SEQRES  37 Y  599  LEU THR GLN ARG PRO ASP TYR ILE LYS ALA VAL VAL LYS          
SEQRES  38 Y  599  LYS ALA GLU LEU LEU SER ARG GLU GLN LYS TYR GLU ASP          
SEQRES  39 Y  599  GLY ILE ALA LEU LEU ARG ASN ALA LEU ALA ASN GLN SER          
SEQRES  40 Y  599  ASP CYS VAL LEU HIS ARG ILE LEU GLY ASP PHE LEU VAL          
SEQRES  41 Y  599  ALA VAL ASN GLU TYR GLN GLU ALA MET ASP GLN TYR SER          
SEQRES  42 Y  599  ILE ALA LEU SER LEU ASP PRO ASN ASP GLN LYS SER LEU          
SEQRES  43 Y  599  GLU GLY MET GLN LYS MET GLU LYS GLU GLU SER PRO THR          
SEQRES  44 Y  599  ASP ALA THR GLN GLU GLU ASP VAL ASP ASP MET GLU GLY          
SEQRES  45 Y  599  SER GLY GLU GLU GLY ASP LEU GLU GLY SER ASP SER GLU          
SEQRES  46 Y  599  ALA ALA GLN TRP ALA ASP GLN GLU GLN TRP PHE GLY MET          
SEQRES  47 Y  599  GLN                                                          
HET     ZN  B1085       1                                                       
HET     ZN  B1086       1                                                       
HET     ZN  B1087       1                                                       
HETNAM      ZN ZINC ION                                                         
FORMUL  22   ZN    3(ZN 2+)                                                     
HELIX    1   1 PHE A   23  CYS A   28  1                                   6    
HELIX    2   2 SER A  615  LEU A  629  1                                  15    
HELIX    3   3 LYS A  631  SER A  646  1                                  16    
HELIX    4   4 SER A  655  GLY A  669  1                                  15    
HELIX    5   5 HIS A  758  LEU A  775  1                                  18    
HELIX    6   6 GLU A  781  LEU A  790  1                                  10    
HELIX    7   7 GLY A  800  TYR A  810  1                                  11    
HELIX    8   8 SER A  843  GLY A  854  1                                  12    
HELIX    9   9 CYS A  867  LEU A  882  1                                  16    
HELIX   10  10 SER A  924  VAL A  937  1                                  14    
HELIX   11  11 THR A  940  GLU A  945  1                                   6    
HELIX   12  12 PRO A  948  GLN A  965  1                                  18    
HELIX   13  13 PRO A  971  ILE A  978  1                                   8    
HELIX   14  14 ARG A  980  LYS A  985  5                                   6    
HELIX   15  15 ASN A 1020  TRP A 1028  1                                   9    
HELIX   16  16 LEU A 1032  GLN A 1042  1                                  11    
HELIX   17  17 SER A 1058  THR A 1088  1                                  31    
HELIX   18  18 THR A 1132  LYS A 1146  1                                  15    
HELIX   19  19 ASP A 1154  ASN A 1161  1                                   8    
HELIX   20  20 LEU A 1168  GLY A 1183  1                                  16    
HELIX   21  21 HIS A 1184  LEU A 1188  5                                   5    
HELIX   22  22 ALA A 1189  ILE A 1193  5                                   5    
HELIX   23  23 HIS A 1201  LEU A 1217  1                                  17    
HELIX   24  24 ASP A 1221  LEU A 1228  1                                   8    
HELIX   25  25 PRO A 1246  TYR A 1261  1                                  16    
HELIX   26  26 HIS A 1266  GLY A 1278  1                                  13    
HELIX   27  27 ASP A 1290  LEU A 1307  1                                  18    
HELIX   28  28 ASN A 1320  GLY A 1331  1                                  12    
HELIX   29  29 ASN A 1359  TYR A 1375  1                                  17    
HELIX   30  30 ASN A 1380  LEU A 1387  1                                   8    
HELIX   31  31 THR A 1392  VAL A 1399  1                                   8    
HELIX   32  32 LYS A 1400  LEU A 1415  1                                  16    
HELIX   33  33 ASN A 1422  ASN A 1429  1                                   8    
HELIX   34  34 PRO A 1431  ASN A 1437  1                                   7    
HELIX   35  35 ASN A 1453  PHE A 1476  1                                  24    
HELIX   36  36 ASN A 1481  SER A 1500  1                                  20    
HELIX   37  37 ASN A 1503  GLY A 1508  1                                   6    
HELIX   38  38 GLY A 1508  MET A 1527  1                                  20    
HELIX   39  39 ASN A 1532  THR A 1546  1                                  15    
HELIX   40  40 ASN A 1551  PHE A 1566  1                                  16    
HELIX   41  41 LEU A 1567  GLY A 1570  5                                   4    
HELIX   42  42 ASN A 1578  LEU A 1588  1                                  11    
HELIX   43  43 LEU A 1603  HIS A 1608  5                                   6    
HELIX   44  44 LEU A 1609  ALA A 1613  1                                   5    
HELIX   45  45 THR A 1684  LYS A 1693  1                                  10    
HELIX   46  46 ASP A 1744  CYS A 1755  1                                  12    
HELIX   47  47 LYS A 1764  GLN A 1781  1                                  18    
HELIX   48  48 GLU A 1785  ARG A 1803  1                                  19    
HELIX   49  49 THR A 1808  SER A 1822  1                                  15    
HELIX   50  50 PHE A 1844  GLY A 1863  1                                  20    
HELIX   51  51 GLY A 1864  SER A 1873  1                                  10    
HELIX   52  52 GLU A 1878  SER A 1893  1                                  16    
HELIX   53  53 SER A 1911  LYS A 1920  1                                  10    
HELIX   54  54 PRO A 1925  ARG A 1931  1                                   7    
HELIX   55  55 MET B   57  GLN B   68  1                                  12    
HELIX   56  56 LEU C   29  GLY C   47  1                                  19    
HELIX   57  57 LEU C   48  LEU C   62  1                                  15    
HELIX   58  58 THR C   77  LYS C   97  1                                  21    
HELIX   59  59 GLU C   98  LEU C  106  1                                   9    
HELIX   60  60 LYS C  112  SER C  137  1                                  26    
HELIX   61  61 ALA C  150  ARG C  165  1                                  16    
HELIX   62  62 GLY C  169  LEU C  182  1                                  14    
HELIX   63  63 LEU C  184  LEU C  199  1                                  16    
HELIX   64  64 HIS C  202  ILE C  213  1                                  12    
HELIX   65  65 ASP C  215  LEU C  222  1                                   8    
HELIX   66  66 TRP C  228  GLN C  242  1                                  15    
HELIX   67  67 LEU C  243  VAL C  257  1                                  15    
HELIX   68  68 GLY C  258  LYS C  261  5                                   4    
HELIX   69  69 SER C  262  ARG C  277  1                                  16    
HELIX   70  70 ASP C  278  ASP C  293  1                                  16    
HELIX   71  71 ASN C  299  ARG C  310  1                                  12    
HELIX   72  72 MET C  312  ASP C  327  1                                  16    
HELIX   73  73 ARG C  330  ARG C  344  1                                  15    
HELIX   74  74 GLN C  346  LEU C  360  1                                  15    
HELIX   75  75 LEU C  365  MET C  378  1                                  14    
HELIX   76  76 ASN C  380  ASN C  395  1                                  16    
HELIX   77  77 ASP C  398  LEU C  412  1                                  15    
HELIX   78  78 MET C  414  GLN C  427  1                                  14    
HELIX   79  79 ASP C  432  LEU C  439  1                                   8    
HELIX   80  80 GLU C  441  ASN C  447  1                                   7    
HELIX   81  81 GLN C  448  GLY C  463  1                                  16    
HELIX   82  82 MET C  468  LEU C  480  1                                  13    
HELIX   83  83 SER C  483  CYS C  500  1                                  18    
HELIX   84  84 THR C  511  CYS C  523  1                                  13    
HELIX   85  85 LEU C  525  ASN C  540  1                                  16    
HELIX   86  86 ARG C  543  ARG C  557  1                                  15    
HELIX   87  87 VAL D   25  GLU D   46  1                                  22    
HELIX   88  88 ARG E   52  ASP E   92  1                                  41    
HELIX   89  89 GLU E   93  PHE E   96  5                                   4    
HELIX   90  90 PRO E   98  LEU E  103  1                                   6    
HELIX   91  91 GLU F    6  HIS F   18  1                                  13    
HELIX   92  92 ALA F   20  HIS F   36  1                                  17    
HELIX   93  93 SER F   37  SER F   51  1                                  15    
HELIX   94  94 LYS F   53  HIS F   64  1                                  12    
HELIX   95  95 THR F   68  LEU F   82  1                                  15    
HELIX   96  96 LYS F   84  GLY F   94  1                                  11    
HELIX   97  97 HIS F  103  GLY F  111  1                                   9    
HELIX   98  98 SER F  113  ASP F  129  1                                  17    
HELIX   99  99 ARG F  130  ASN F  145  1                                  16    
HELIX  100 100 LEU F  148  ILE F  158  1                                  11    
HELIX  101 101 ALA F  451  SER F  478  1                                  28    
HELIX  102 102 ASN F  480  HIS F  490  1                                  11    
HELIX  103 103 THR F  498  SER F  513  1                                  16    
HELIX  104 104 GLU F  514  GLU F  529  1                                  16    
HELIX  105 105 GLY F  535  LEU F  546  1                                  12    
HELIX  106 106 LYS F  548  ASP F  563  1                                  16    
HELIX  107 107 SER F  566  GLN F  580  1                                  15    
HELIX  108 108 GLU F  582  ASP F  597  1                                  16    
HELIX  109 109 TYR F  600  GLU F  615  1                                  16    
HELIX  110 110 GLU F  616  ASN F  631  1                                  16    
HELIX  111 111 HIS F  634  GLN F  648  1                                  15    
HELIX  112 112 LYS F  650  ASN F  665  1                                  16    
HELIX  113 113 SER F  668  LYS F  683  1                                  16    
HELIX  114 114 LYS F  684  ASP F  699  1                                  16    
HELIX  115 115 ASN F  702  ASN F  716  1                                  15    
HELIX  116 116 LYS F  718  VAL F  733  1                                  16    
HELIX  117 117 GLU F  736  GLY F  751  1                                  16    
HELIX  118 118 GLN F  752  ASP F  767  1                                  16    
HELIX  119 119 LYS F  769  ARG F  782  1                                  14    
HELIX  120 120 LYS G   12  ASP G   25  1                                  14    
HELIX  121 121 GLU H    6  HIS H   18  1                                  13    
HELIX  122 122 ALA H   20  HIS H   36  1                                  17    
HELIX  123 123 SER H   37  SER H   51  1                                  15    
HELIX  124 124 LYS H   53  HIS H   64  1                                  12    
HELIX  125 125 THR H   68  LEU H   82  1                                  15    
HELIX  126 126 LYS H   84  GLY H   94  1                                  11    
HELIX  127 127 HIS H  103  GLY H  111  1                                   9    
HELIX  128 128 SER H  113  ASP H  129  1                                  17    
HELIX  129 129 ARG H  130  ASN H  145  1                                  16    
HELIX  130 130 LEU H  148  ILE H  158  1                                  11    
HELIX  131 131 PRO H  164  LYS H  169  1                                   6    
HELIX  132 132 ALA H  451  TYR H  479  1                                  29    
HELIX  133 133 ASN H  480  HIS H  490  1                                  11    
HELIX  134 134 THR H  498  SER H  513  1                                  16    
HELIX  135 135 GLU H  514  GLU H  529  1                                  16    
HELIX  136 136 GLY H  535  LEU H  546  1                                  12    
HELIX  137 137 LYS H  548  ASP H  563  1                                  16    
HELIX  138 138 SER H  566  GLN H  580  1                                  15    
HELIX  139 139 GLU H  582  ASP H  597  1                                  16    
HELIX  140 140 TYR H  600  GLU H  615  1                                  16    
HELIX  141 141 GLU H  616  ASN H  631  1                                  16    
HELIX  142 142 HIS H  634  GLN H  648  1                                  15    
HELIX  143 143 LYS H  650  ASN H  665  1                                  16    
HELIX  144 144 SER H  668  LYS H  683  1                                  16    
HELIX  145 145 LYS H  684  ASP H  699  1                                  16    
HELIX  146 146 ASN H  702  ASN H  716  1                                  15    
HELIX  147 147 LYS H  718  VAL H  733  1                                  16    
HELIX  148 148 GLU H  736  GLY H  751  1                                  16    
HELIX  149 149 GLN H  752  ASP H  767  1                                  16    
HELIX  150 150 LEU I   49  PHE I   52  5                                   4    
HELIX  151 151 GLU I  132  LEU I  137  1                                   6    
HELIX  152 152 GLU I  163  ASP I  170  1                                   8    
HELIX  153 153 TYR I  190  MET I  192  5                                   3    
HELIX  154 154 THR I  238  PHE I  244  1                                   7    
HELIX  155 155 PHE I  244  LYS I  294  1                                  51    
HELIX  156 156 SER I  299  TRP I  310  1                                  12    
HELIX  157 157 ALA I  315  LEU I  325  1                                  11    
HELIX  158 158 THR I  326  HIS I  351  1                                  26    
HELIX  159 159 HIS I  351  TRP I  372  1                                  22    
HELIX  160 160 TRP I  372  GLU I  377  1                                   6    
HELIX  161 161 ASP I  382  THR I  429  1                                  48    
HELIX  162 162 THR I  441  PHE I  456  1                                  16    
HELIX  163 163 ARG I  474  LYS I  480  1                                   7    
HELIX  164 164 ASN I  495  ASN I  503  1                                   9    
HELIX  165 165 SER I  521  MET I  548  1                                  28    
HELIX  166 166 SER I  672  VAL I  674  5                                   3    
HELIX  167 167 ASP I  679  TYR I  683  5                                   5    
HELIX  168 168 ASN J    2  GLN J   17  1                                  16    
HELIX  169 169 GLN J   18  ARG J   34  1                                  17    
HELIX  170 170 GLU J   36  THR J   50  1                                  15    
HELIX  171 171 GLN J   52  ARG J   63  1                                  12    
HELIX  172 172 LYS J   64  GLU J   70  1                                   7    
HELIX  173 173 GLU J   70  LYS J   84  1                                  15    
HELIX  174 174 GLN J   88  ASP J   94  1                                   7    
HELIX  175 175 SER J  124  LEU J  143  1                                  20    
HELIX  176 176 ASN J  145  VAL J  161  1                                  17    
HELIX  177 177 CYS J  163  HIS J  173  1                                  11    
HELIX  178 178 THR J  177  LEU J  188  1                                  12    
HELIX  179 179 CYS J  194  LYS J  208  1                                  15    
HELIX  180 180 ASN J  230  CYS J  245  1                                  16    
HELIX  181 181 ASP J  246  ASP J  261  1                                  16    
HELIX  182 182 SER J  266  ASN J  279  1                                  14    
HELIX  183 183 LYS J  280  TYR J  295  1                                  16    
HELIX  184 184 ASN J  298  GLY J  313  1                                  16    
HELIX  185 185 LYS J  315  GLU J  330  1                                  16    
HELIX  186 186 TYR J  333  SER J  348  1                                  16    
HELIX  187 187 GLU J  349  MET J  364  1                                  16    
HELIX  188 188 HIS J  368  THR J  381  1                                  14    
HELIX  189 189 ASN J  383  ILE J  397  1                                  15    
HELIX  190 190 ASP J  401  GLY J  416  1                                  16    
HELIX  191 191 TRP J  418  ALA J  434  1                                  17    
HELIX  192 192 TRP J  444  LYS J  459  1                                  16    
HELIX  193 193 LYS J  460  ILE J  475  1                                  16    
HELIX  194 194 ASN J  478  MET J  492  1                                  15    
HELIX  195 195 ASN J  494  ARG J  509  1                                  16    
HELIX  196 196 ASP J  512  ASP J  529  1                                  18    
HELIX  197 197 ASN K    2  GLN K   17  1                                  16    
HELIX  198 198 GLN K   18  ARG K   34  1                                  17    
HELIX  199 199 GLU K   36  THR K   50  1                                  15    
HELIX  200 200 GLN K   52  SER K   62  1                                  11    
HELIX  201 201 LYS K   64  TYR K   69  1                                   6    
HELIX  202 202 TYR K   69  LYS K   84  1                                  16    
HELIX  203 203 GLN K   88  LEU K   93  1                                   6    
HELIX  204 204 SER K  130  LEU K  143  1                                  14    
HELIX  205 205 ASN K  145  VAL K  161  1                                  17    
HELIX  206 206 CYS K  163  SER K  172  1                                  10    
HELIX  207 207 HIS K  173  MET K  175  5                                   3    
HELIX  208 208 ALA K  178  LEU K  188  1                                  11    
HELIX  209 209 CYS K  194  LYS K  211  1                                  18    
HELIX  210 210 THR K  218  ASP K  225  1                                   8    
HELIX  211 211 GLY K  226  GLU K  229  5                                   4    
HELIX  212 212 ASN K  230  CYS K  245  1                                  16    
HELIX  213 213 ASP K  246  ASP K  261  1                                  16    
HELIX  214 214 SER K  266  ASN K  279  1                                  14    
HELIX  215 215 LYS K  280  TYR K  295  1                                  16    
HELIX  216 216 ASN K  298  GLY K  313  1                                  16    
HELIX  217 217 LYS K  315  GLU K  330  1                                  16    
HELIX  218 218 GLY K  334  SER K  348  1                                  15    
HELIX  219 219 GLU K  349  MET K  364  1                                  16    
HELIX  220 220 CYS K  367  THR K  381  1                                  15    
HELIX  221 221 ASN K  383  ALA K  398  1                                  16    
HELIX  222 222 ASP K  401  GLY K  416  1                                  16    
HELIX  223 223 GLU K  417  ILE K  435  1                                  19    
HELIX  224 224 THR K  440  LYS K  459  1                                  20    
HELIX  225 225 LYS K  460  ILE K  475  1                                  16    
HELIX  226 226 ASN K  478  MET K  492  1                                  15    
HELIX  227 227 ASN K  494  ARG K  509  1                                  16    
HELIX  228 228 ASP K  512  ILE K  527  1                                  16    
HELIX  229 229 ASP L   12  THR L   19  1                                   8    
HELIX  230 230 GLY L   41  ARG L   46  1                                   6    
HELIX  231 231 HIS L  145  GLY L  148  5                                   4    
HELIX  232 232 THR L  174  MET L  179  1                                   6    
HELIX  233 233 ASP M    8  ASP M   16  1                                   9    
HELIX  234 234 SER M   49  MET M   55  1                                   7    
HELIX  235 235 ARG N   15  THR N   29  1                                  15    
HELIX  236 236 GLU N   53  ARG N   63  1                                  11    
HELIX  237 237 VAL N   78  TRP N   92  1                                  15    
HELIX  238 238 ASN N   93  GLU N   99  1                                   7    
HELIX  239 239 CYS N  107  ASP N  123  1                                  17    
HELIX  240 240 LEU N  126  GLY N  139  1                                  14    
HELIX  241 241 ARG N  150  PHE N  162  1                                  13    
HELIX  242 242 ARG N  167  GLY N  191  1                                  25    
HELIX  243 243 LEU N  203  TYR N  213  1                                  11    
HELIX  244 244 ARG N  234  LEU N  250  1                                  17    
HELIX  245 245 LEU N  252  ARG N  278  1                                  27    
HELIX  246 246 ARG N  287  PHE N  304  1                                  18    
HELIX  247 247 ARG N  322  ARG N  349  1                                  28    
HELIX  248 248 SER N  354  ARG N  367  1                                  14    
HELIX  249 249 GLN N  370  LEU N  386  1                                  17    
HELIX  250 250 ASP N  395  VAL N  409  1                                  15    
HELIX  251 251 ILE N  416  CYS N  421  1                                   6    
HELIX  252 252 CYS N  421  GLU N  432  1                                  12    
HELIX  253 253 ASP N  433  LEU N  442  1                                  10    
HELIX  254 254 ASP N  451  LYS N  458  1                                   8    
HELIX  255 255 SER N  499  TYR N  509  1                                  11    
HELIX  256 256 LYS N  512  GLN N  530  1                                  19    
HELIX  257 257 GLU N  536  PHE N  549  1                                  14    
HELIX  258 258 MET N  554  ASP N  563  1                                  10    
HELIX  259 259 MET N  564  LYS N  580  1                                  17    
HELIX  260 260 PRO N  612  LYS N  630  1                                  19    
HELIX  261 261 THR N  660  ASP N  672  1                                  13    
HELIX  262 262 THR N  677  LYS N  686  1                                  10    
HELIX  263 263 PRO N  688  GLY N  703  1                                  16    
HELIX  264 264 THR O   31  SER O   45  1                                  15    
HELIX  265 265 SER O   53  GLY O   70  1                                  18    
HELIX  266 266 THR O   74  CYS O   86  1                                  13    
HELIX  267 267 CYS O   86  GLY O  103  1                                  18    
HELIX  268 268 GLU O  104  GLY O  121  1                                  18    
HELIX  269 269 THR O  129  LEU O  146  1                                  18    
HELIX  270 270 SER O  147  THR O  169  1                                  23    
HELIX  271 271 SER O  208  ASP O  226  1                                  19    
HELIX  272 272 THR O  232  ASN O  247  1                                  16    
HELIX  273 273 ALA O  251  VAL O  264  1                                  14    
HELIX  274 274 ASP O  266  LEU O  281  1                                  16    
HELIX  275 275 ARG O  298  PHE O  314  1                                  17    
HELIX  276 276 HIS O  316  SER O  334  1                                  19    
HELIX  277 277 ASP O  336  GLY O  351  1                                  16    
HELIX  278 278 TYR O  358  HIS O  370  1                                  13    
HELIX  279 279 LEU O  373  ARG O  388  1                                  16    
HELIX  280 280 THR O  394  SER O  413  1                                  20    
HELIX  281 281 LEU O  414  TYR O  432  1                                  19    
HELIX  282 282 ARG O  434  SER O  447  1                                  14    
HELIX  283 283 ASN O  462  GLN O  480  1                                  19    
HELIX  284 284 CYS O  482  PHE O  497  1                                  16    
HELIX  285 285 HIS O  503  GLY O  523  1                                  21    
HELIX  286 286 LYS O  524  ASN O  539  1                                  16    
HELIX  287 287 SER O  540  GLN O  554  1                                  15    
HELIX  288 288 GLN O  556  LEU O  574  1                                  19    
HELIX  289 289 ASN O  576  TRP O  592  1                                  17    
HELIX  290 290 SER O  596  ILE O  599  5                                   4    
HELIX  291 291 ALA O  600  ARG O  615  1                                  16    
HELIX  292 292 LEU O  616  LEU O  634  1                                  19    
HELIX  293 293 ILE O  636  ASP O  654  1                                  19    
HELIX  294 294 ILE O  657  ALA O  676  1                                  20    
HELIX  295 295 LYS O  682  ASP O  705  1                                  24    
HELIX  296 296 ARG O  709  GLY O  725  1                                  17    
HELIX  297 297 LYS O  726  HIS O  741  1                                  16    
HELIX  298 298 ASP P   28  GLY P   47  1                                  20    
HELIX  299 299 LEU P   48  LEU P   62  1                                  15    
HELIX  300 300 THR P   77  LYS P   97  1                                  21    
HELIX  301 301 GLU P   98  LEU P  106  1                                   9    
HELIX  302 302 HIS P  107  CYS P  109  5                                   3    
HELIX  303 303 SER P  111  THR P  134  1                                  24    
HELIX  304 304 ASN P  148  ARG P  165  1                                  18    
HELIX  305 305 GLY P  169  LEU P  182  1                                  14    
HELIX  306 306 LEU P  184  LEU P  199  1                                  16    
HELIX  307 307 HIS P  202  ILE P  213  1                                  12    
HELIX  308 308 ASP P  215  LEU P  222  1                                   8    
HELIX  309 309 TRP P  228  LEU P  241  1                                  14    
HELIX  310 310 LEU P  243  VAL P  257  1                                  15    
HELIX  311 311 SER P  262  ILE P  276  1                                  15    
HELIX  312 312 ASP P  278  ASP P  293  1                                  16    
HELIX  313 313 ASN P  299  ARG P  310  1                                  12    
HELIX  314 314 MET P  312  ASP P  327  1                                  16    
HELIX  315 315 ARG P  330  ARG P  344  1                                  15    
HELIX  316 316 GLN P  346  LEU P  360  1                                  15    
HELIX  317 317 LEU P  365  MET P  378  1                                  14    
HELIX  318 318 ASN P  380  ASN P  395  1                                  16    
HELIX  319 319 ASP P  398  LEU P  412  1                                  15    
HELIX  320 320 MET P  414  GLN P  427  1                                  14    
HELIX  321 321 ASP P  432  ASN P  447  1                                  16    
HELIX  322 322 GLN P  448  GLY P  463  1                                  16    
HELIX  323 323 MET P  468  LEU P  480  1                                  13    
HELIX  324 324 SER P  483  CYS P  500  1                                  18    
HELIX  325 325 THR P  511  CYS P  523  1                                  13    
HELIX  326 326 LEU P  525  ALA P  538  1                                  14    
HELIX  327 327 SER R   84  LYS R   97  1                                  14    
HELIX  328 328 PRO R  107  ASN R  121  1                                  15    
HELIX  329 329 ASP R  124  ALA R  128  5                                   5    
HELIX  330 330 LYS W   12  ASP W   25  1                                  14    
HELIX  331 331 ASN X   36  GLY X   48  1                                  13    
HELIX  332 332 LEU X   49  ASN X   67  1                                  19    
HELIX  333 333 SER X   72  ASP X   90  1                                  19    
HELIX  334 334 GLU X   92  LEU X  110  1                                  19    
HELIX  335 335 SER X  134  LYS X  150  1                                  17    
HELIX  336 336 GLN X  151  ILE X  162  1                                  12    
HELIX  337 337 THR X  168  GLY X  183  1                                  16    
HELIX  338 338 GLN X  184  CYS X  199  1                                  16    
HELIX  339 339 ALA X  202  SER X  213  1                                  12    
HELIX  340 340 VAL X  214  THR X  229  1                                  16    
HELIX  341 341 TRP X  235  GLY X  249  1                                  15    
HELIX  342 342 ASP X  250  LYS X  264  1                                  15    
HELIX  343 343 ASN X  270  GLY X  285  1                                  16    
HELIX  344 344 ASP X  286  ASP X  301  1                                  16    
HELIX  345 345 LEU X  304  GLU X  318  1                                  15    
HELIX  346 346 ARG X  320  SER X  335  1                                  16    
HELIX  347 347 HIS X  338  LYS X  353  1                                  16    
HELIX  348 348 ARG X  354  ASN X  369  1                                  16    
HELIX  349 349 SER X  372  MET X  386  1                                  15    
HELIX  350 350 ARG X  388  ALA X  403  1                                  16    
HELIX  351 351 ARG X  406  ASN X  421  1                                  16    
HELIX  352 352 SER X  422  GLY X  438  1                                  17    
HELIX  353 353 ALA X  441  ASP X  454  1                                  14    
HELIX  354 354 THR X  457  ARG X  472  1                                  16    
HELIX  355 355 TYR X  475  GLN X  490  1                                  16    
HELIX  356 356 TYR X  492  GLN X  506  1                                  15    
HELIX  357 357 CYS X  509  ASN X  523  1                                  15    
HELIX  358 358 GLU X  524  ASP X  539  1                                  16    
HELIX  359 359 ASN Y   36  GLY Y   48  1                                  13    
HELIX  360 360 LEU Y   49  ASN Y   67  1                                  19    
HELIX  361 361 SER Y   72  LYS Y   91  1                                  20    
HELIX  362 362 GLU Y   92  LEU Y  110  1                                  19    
HELIX  363 363 SER Y  134  LYS Y  150  1                                  17    
HELIX  364 364 GLN Y  151  ILE Y  162  1                                  12    
HELIX  365 365 THR Y  168  GLY Y  183  1                                  16    
HELIX  366 366 GLN Y  184  CYS Y  199  1                                  16    
HELIX  367 367 ALA Y  202  SER Y  213  1                                  12    
HELIX  368 368 VAL Y  214  THR Y  229  1                                  16    
HELIX  369 369 TRP Y  235  GLY Y  249  1                                  15    
HELIX  370 370 ASP Y  250  LYS Y  264  1                                  15    
HELIX  371 371 ASN Y  270  GLY Y  285  1                                  16    
HELIX  372 372 ASP Y  286  ASP Y  301  1                                  16    
HELIX  373 373 LEU Y  304  GLY Y  319  1                                  16    
HELIX  374 374 ARG Y  320  SER Y  335  1                                  16    
HELIX  375 375 HIS Y  338  LYS Y  353  1                                  16    
HELIX  376 376 ARG Y  354  ASN Y  369  1                                  16    
HELIX  377 377 SER Y  372  GLY Y  387  1                                  16    
HELIX  378 378 ARG Y  388  ALA Y  403  1                                  16    
HELIX  379 379 ARG Y  406  ASN Y  421  1                                  16    
HELIX  380 380 SER Y  422  GLY Y  438  1                                  17    
HELIX  381 381 ALA Y  441  ASP Y  454  1                                  14    
HELIX  382 382 THR Y  457  ARG Y  472  1                                  16    
HELIX  383 383 TYR Y  475  GLN Y  490  1                                  16    
HELIX  384 384 TYR Y  492  GLN Y  506  1                                  15    
HELIX  385 385 CYS Y  509  ASN Y  523  1                                  15    
HELIX  386 386 GLU Y  524  ASP Y  539  1                                  16    
HELIX  387 387 ASP Y  542  MET Y  552  1                                  11    
SHEET    1  AA 4 GLN A  18  GLU A  19  0                                        
SHEET    2  AA 4 MET A 604  THR A 608 -1  O  ARG A 606   N  GLN A  18           
SHEET    3  AA 4 ARG A 594  GLU A 598 -1  O  VAL A 595   N  ILE A 607           
SHEET    4  AA 4 SER A 586  VAL A 591 -1  O  SER A 586   N  GLU A 598           
SHEET    1  AB 4 SER A  73  LYS A  78  0                                        
SHEET    2  AB 4 ASP A  90  VAL A  95 -1  O  GLU A  91   N  ARG A  77           
SHEET    3  AB 4 MET A  99  SER A 103 -1  O  ILE A 101   N  TYR A  94           
SHEET    4  AB 4 VAL A 113  THR A 118 -1  N  TYR A 114   O  TRP A 102           
SHEET    1  AC 4 LEU A 127  ILE A 132  0                                        
SHEET    2  AC 4 VAL A 147  LEU A 154 -1  O  GLU A 148   N  PHE A 131           
SHEET    3  AC 4 CYS A 158  HIS A 162 -1  O  ASN A 160   N  ILE A 153           
SHEET    4  AC 4 ASP A 168  SER A 172 -1  O  TYR A 169   N  MET A 161           
SHEET    1  AD 4 VAL A 177  VAL A 180  0                                        
SHEET    2  AD 4 PHE A 189  ARG A 191 -1  O  GLU A 190   N  ALA A 178           
SHEET    3  AD 4 MET A 210  SER A 212 -1  O  PHE A 211   N  PHE A 189           
SHEET    4  AD 4 THR A 221  PRO A 222 -1  O  THR A 221   N  SER A 212           
SHEET    1  AE 4 GLN A 237  TYR A 238  0                                        
SHEET    2  AE 4 VAL A 224  CYS A 225 -1  O  CYS A 225   N  GLN A 237           
SHEET    3  AE 4 CYS A 408  ILE A 409  1  N  ILE A 409   O  VAL A 224           
SHEET    4  AE 4 LEU A 271  ARG A 272 -1  O  ARG A 272   N  CYS A 408           
SHEET    1  AF 3 LYS A 245  ASN A 250  0                                        
SHEET    2  AF 3 ILE A 255  TYR A 259 -1  O  ILE A 255   N  ASN A 250           
SHEET    3  AF 3 HIS A 266  TRP A 269 -1  O  SER A 267   N  THR A 258           
SHEET    1  AG 3 ILE A 432  SER A 434  0                                        
SHEET    2  AG 3 LYS A 440  LEU A 445 -1  O  PHE A 441   N  THR A 433           
SHEET    3  AG 3 LEU A 452  CYS A 454 -1  O  ARG A 453   N  PHE A 444           
SHEET    1  AH 2 GLN A 458  GLU A 459  0                                        
SHEET    2  AH 2 LEU A 466  ILE A 467 -1  O  ILE A 467   N  GLN A 458           
SHEET    1  AI 3 MET A 488  GLU A 492  0                                        
SHEET    2  AI 3 ASN A 496  TYR A 500 -1  O  ASN A 496   N  GLU A 492           
SHEET    3  AI 3 ARG A 505  LYS A 508 -1  N  VAL A 506   O  LEU A 499           
SHEET    1  AJ 2 THR A1108  ALA A1111  0                                        
SHEET    2  AJ 2 THR A1116  ASP A1119 -1  O  THR A1116   N  ALA A1111           
SHEET    1  AK 2 TYR A1572  LEU A1574  0                                        
SHEET    2  AK 2 ALA A1614  PRO A1616 -1  O  GLU A1615   N  SER A1573           
SHEET    1  AL 2 VAL A1620  VAL A1622  0                                        
SHEET    2  AL 2 VAL A1696  TYR A1698  1  O  LEU A1697   N  VAL A1622           
SHEET    1  AM 4 LYS A1648  GLU A1649  0                                        
SHEET    2  AM 4 GLU A1635  TYR A1638 -1  O  VAL A1636   N  GLU A1649           
SHEET    3  AM 4 LEU A1663  VAL A1668 -1  N  LYS A1664   O  THR A1637           
SHEET    4  AM 4 GLU A1675  ILE A1678 -1  O  GLU A1675   N  VAL A1668           
SHEET    1  NA 4 GLY N 590  ALA N 593  0                                        
SHEET    2  NA 4 VAL B   3  GLY B  10  1  O  LYS B   6   N  GLY N 590           
SHEET    3  NA 4 LEU N 643  VAL N 648 -1  O  LEU N 643   N  ASN B   9           
SHEET    4  NA 4 LEU N 655  SER N 656 -1  O  LEU N 655   N  VAL N 648           
SHEET    1  BA 2 LEU B  46  TRP B  48  0                                        
SHEET    2  BA 2 CYS B  54  HIS B  56 -1  O  PHE B  55   N  VAL B  47           
SHEET    1  IA 4 ILE I  23  TRP I  28  0                                        
SHEET    2  IA 4 ILE I  35  ASN I  39 -1  O  ALA I  36   N  VAL I  27           
SHEET    3  IA 4 VAL I  44  HIS I  47 -1  O  LEU I  45   N  LEU I  37           
SHEET    4  IA 4 ARG I  54  PHE I  58 -1  N  VAL I  55   O  LEU I  46           
SHEET    1  IB 4 VAL I  68  TRP I  73  0                                        
SHEET    2  IB 4 LEU I  79  LEU I  84 -1  O  ALA I  81   N  ALA I  72           
SHEET    3  IB 4 ILE I  90  ASP I  94 -1  O  VAL I  91   N  PHE I  82           
SHEET    4  IB 4 SER I 103  PHE I 104 -1  O  PHE I 104   N  ILE I  90           
SHEET    1  IC 2 CYS I 112  GLU I 117  0                                        
SHEET    2  IC 2 ASN I 174  GLY I 179 -1  O  ILE I 175   N  MET I 116           
SHEET    1  ID 2 PHE I 184  ALA I 189  0                                        
SHEET    2  ID 2 PHE I 193  THR I 199 -1  O  PHE I 193   N  ALA I 189           
SHEET    1  IE 4 THR I 204  LEU I 210  0                                        
SHEET    2  IE 4 SER I 216  GLU I 222 -1  O  SER I 218   N  CYS I 209           
SHEET    3  IE 4 TYR I 233  GLU I 237 -1  O  PHE I 234   N  VAL I 219           
SHEET    4  IE 4 ALA I 551  ILE I 554 -1  O  ILE I 552   N  GLN I 235           
SHEET    1  IF 2 SER I 229  GLU I 230  0                                        
SHEET    2  IF 2 ARG I 558  ASP I 559 -1  O  ASP I 559   N  SER I 229           
SHEET    1  IG 5 PHE I 574  ASN I 578  0                                        
SHEET    2  IG 5 LEU I 583  LEU I 591 -1  O  LEU I 583   N  ASN I 578           
SHEET    3  IG 5 TYR I 596  HIS I 604 -1  O  LYS I 597   N  ILE I 590           
SHEET    4  IG 5 LEU I 615  THR I 624 -1  O  ILE I 616   N  ILE I 600           
SHEET    5  IG 5 VAL I 631  ARG I 632 -1  O  ARG I 632   N  PHE I 623           
SHEET    1  IH 5 PHE I 574  ASN I 578  0                                        
SHEET    2  IH 5 LEU I 583  LEU I 591 -1  O  LEU I 583   N  ASN I 578           
SHEET    3  IH 5 TYR I 596  HIS I 604 -1  O  LYS I 597   N  ILE I 590           
SHEET    4  IH 5 LEU I 615  THR I 624 -1  O  ILE I 616   N  ILE I 600           
SHEET    5  IH 5 THR I 702  PHE I 707  1  O  ARG I 703   N  LYS I 619           
SHEET    1  II 2 VAL I 631  ARG I 632  0                                        
SHEET    2  II 2 LEU I 615  THR I 624 -1  O  PHE I 623   N  ARG I 632           
SHEET    1  IJ 4 TYR I 636  ASP I 645  0                                        
SHEET    2  IJ 4 THR I 648  ASP I 655 -1  O  THR I 648   N  TYR I 644           
SHEET    3  IJ 4 ARG I 664  PRO I 670 -1  O  LEU I 665   N  LEU I 653           
SHEET    4  IJ 4 TRP I 711  LEU I 713 -1  O  ARG I 712   N  LEU I 666           
SHEET    1  IK 3 ALA I 719  GLY I 724  0                                        
SHEET    2  IK 3 VAL I 730  SER I 735 -1  O  CYS I 732   N  ALA I 723           
SHEET    3  IK 3 VAL I 741  GLU I 745 -1  O  ARG I 742   N  VAL I 733           
SHEET    1  LA 4 VAL L  22  GLU L  24  0                                        
SHEET    2  LA 4 GLN L 155  PRO L 161 -1  O  THR L 160   N  ARG L  23           
SHEET    3  LA 4 THR L  76  TYR L  80 -1  O  THR L  76   N  TYR L 159           
SHEET    4  LA 4 TRP L 119  PRO L 123 -1  O  ILE L 120   N  ILE L  79           
SHEET    1  LB 5 VAL L  30  LEU L  33  0                                        
SHEET    2  LB 5 HIS L  62  VAL L  74 -1  O  ASN L  65   N  SER L  32           
SHEET    3  LB 5 THR L 132  VAL L 141 -1  O  THR L 132   N  VAL L  74           
SHEET    4  LB 5 LYS L  93  GLY L  99 -1  O  SER L  95   N  ALA L 140           
SHEET    5  LB 5 GLN L 106  GLU L 112 -1  O  GLN L 106   N  VAL L  98           
SHEET    1  LC 2 TRP L  54  GLN L  55  0                                        
SHEET    2  LC 2 HIS L 152  MET L 153 -1  O  MET L 153   N  TRP L  54           
SHEET    1  RA 4 ILE R 175  ASP R 177  0                                        
SHEET    2  RA 4 THR R 466  TRP R 470 -1  O  LEU R 467   N  LEU R 176           
SHEET    3  RA 4 VAL R 458  ALA R 462 -1  O  VAL R 458   N  TRP R 470           
SHEET    4  RA 4 VAL R 446  MET R 451 -1  N  LEU R 447   O  ALA R 461           
SHEET    1  RB 4 VAL R 190  TRP R 192  0                                        
SHEET    2  RB 4 VAL R 197  LEU R 202 -1  O  ALA R 199   N  ASP R 191           
SHEET    3  RB 4 SER R 205  SER R 210 -1  O  SER R 205   N  LEU R 202           
SHEET    4  RB 4 ILE R 216  GLN R 221 -1  O  LEU R 217   N  LEU R 208           
SHEET    1  RC 4 ILE R 229  TRP R 234  0                                        
SHEET    2  RC 4 TYR R 240  THR R 245 -1  O  ALA R 242   N  ALA R 233           
SHEET    3  RC 4 VAL R 250  ASP R 254 -1  O  GLN R 251   N  VAL R 243           
SHEET    4  RC 4 LYS R 259  MET R 264 -1  O  LYS R 259   N  ASP R 254           
SHEET    1  RD 4 VAL R 271  ASN R 277  0                                        
SHEET    2  RD 4 ILE R 280  SER R 285 -1  O  ILE R 280   N  ASN R 277           
SHEET    3  RD 4 HIS R 289  ASP R 294 -1  O  HIS R 289   N  SER R 285           
SHEET    4  RD 4 HIS R 301  SER R 306 -1  N  VAL R 302   O  HIS R 292           
SHEET    1  RE 4 VAL R 312  TRP R 317  0                                        
SHEET    2  RE 4 HIS R 323  GLY R 328 -1  O  ALA R 325   N  ARG R 316           
SHEET    3  RE 4 VAL R 333  PRO R 337 -1  O  ASN R 334   N  SER R 326           
SHEET    4  RE 4 GLN R 349  PHE R 351 -1  O  GLN R 349   N  VAL R 335           
SHEET    1  RF 4 ALA R 360  TRP R 363  0                                        
SHEET    2  RF 4 VAL R 370  GLY R 374 -1  O  ALA R 372   N  ALA R 362           
SHEET    3  RF 4 HIS R 381  ASN R 386 -1  O  ARG R 383   N  THR R 373           
SHEET    4  RF 4 CYS R 392  ASP R 397 -1  N  LEU R 393   O  ILE R 384           
SHEET    1  RG 4 VAL R 402  SER R 408  0                                        
SHEET    2  RG 4 GLU R 413  HIS R 418 -1  O  GLU R 413   N  SER R 408           
SHEET    3  RG 4 LEU R 425  LYS R 429 -1  O  VAL R 426   N  SER R 416           
SHEET    4  RG 4 LYS R 435  LEU R 439 -1  N  VAL R 436   O  ILE R 427           
CISPEP   1 PRO A   44    ALA A   45          0         8.21                     
CISPEP   2 VAL A  240    ASP A  241          0        -0.54                     
CISPEP   3 ASN A  264    VAL A  265          0        -9.51                     
CISPEP   4 ALA A  476    LYS A  477          0        -8.75                     
CISPEP   5 THR A  582    TYR A  583          0         1.39                     
CISPEP   6 LEU A  755    PHE A  756          0        -0.31                     
CISPEP   7 LEU A  793    ALA A  794          0         5.14                     
CISPEP   8 LEU A 1100    PRO A 1101          0       -16.92                     
CISPEP   9 PRO A 1112    PRO A 1113          0        -1.72                     
CISPEP  10 PRO A 1238    THR A 1239          0        -8.47                     
CISPEP  11 THR A 1239    SER A 1240          0       -15.28                     
CISPEP  12 GLY A 1670    PRO A 1671          0        -8.10                     
CISPEP  13 SER A 1739    ALA A 1740          0        24.66                     
CISPEP  14 TRP B   14    LEU B   15          0         2.21                     
CISPEP  15 GLN B   68    VAL B   69          0        -8.85                     
CISPEP  16 VAL C   96    LYS C   97          0        17.33                     
CISPEP  17 ASN C  361    PRO C  362          0        -0.14                     
CISPEP  18 ASN F  145    PRO F  146          0        -2.50                     
CISPEP  19 ASN H  145    PRO H  146          0        -2.40                     
CISPEP  20 PHE I  572    PRO I  573          0        -0.36                     
CISPEP  21 GLN L   60    PRO L   61          0         5.29                     
CISPEP  22 THR L  125    ASP L  126          0       -15.66                     
CISPEP  23 PHE L  170    PRO L  171          0        -5.49                     
CISPEP  24 ARG N   63    GLY N   64          0         2.15                     
CISPEP  25 TYR N  125    LEU N  126          0         4.44                     
CISPEP  26 PHE N  162    PHE N  163          0        19.59                     
CISPEP  27 SER N  164    THR N  165          0       -23.11                     
CISPEP  28 THR N  165    PRO N  166          0       -13.50                     
CISPEP  29 PRO N  197    GLU N  198          0         4.69                     
CISPEP  30 GLU N  280    TYR N  281          0        26.54                     
CISPEP  31 SER N  284    PHE N  285          0       -21.96                     
CISPEP  32 ASP N  350    PHE N  351          0       -10.59                     
CISPEP  33 THR N  368    ASP N  369          0       -10.51                     
CISPEP  34 PRO N  477    GLU N  478          0         6.46                     
CISPEP  35 GLU N  478    ASP N  479          0        -0.30                     
CISPEP  36 ASP N  483    PRO N  484          0        -0.37                     
CISPEP  37 PRO N  484    VAL N  485          0         3.46                     
CISPEP  38 SER N  493    SER N  494          0         4.47                     
CISPEP  39 TYR N  509    GLY N  510          0         0.04                     
CISPEP  40 SER N  532    PHE N  533          0        -4.60                     
CISPEP  41 GLY N  550    GLU N  551          0       -13.91                     
CISPEP  42 PRO N  709    PRO N  710          0        -0.96                     
CISPEP  43 GLU O  123    PRO O  124          0        -4.08                     
CISPEP  44 ASP O  356    SER O  357          0         6.04                     
CISPEP  45 VAL P   96    LYS P   97          0        14.82                     
CISPEP  46 ASN P  361    PRO P  362          0         0.95                     
CISPEP  47 PRO R   74    GLY R   75          0        -4.88                     
CISPEP  48 LYS R   97    GLU R   98          0        -2.76                     
CISPEP  49 ASN R   99    GLN R  100          0         7.83                     
CISPEP  50 GLN R  100    PRO R  101          0        -4.51                     
CISPEP  51 ALA R  128    LYS R  129          0        12.14                     
CISPEP  52 PHE R  420    ALA R  421          0        -1.62                     
CISPEP  53 TYR R  430    PRO R  431          0        -1.82                     
SITE     1 AC1  4 CYS B  23  CYS B  26  HIS B  56  CYS B  59                    
SITE     1 AC2  4 CYS B  51  HIS B  53  CYS B  73  CYS B  76                    
SITE     1 AC3  4 CYS B  34  CYS B  37  CYS B  44  HIS B  58                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system