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Database: PDB
Entry: 5GAM
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Original site: 5GAM 
HEADER    TRANSCRIPTION                           15-DEC-15   5GAM              
TITLE     FOOT REGION OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: U5 SNRNA;                                                  
COMPND   3 CHAIN: U;                                                            
COMPND   4 OTHER_DETAILS: SHORT FORM OF U5 SNRNA (179 NT);                      
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: PRE-MRNA-SPLICING FACTOR 8;                                
COMPND   7 CHAIN: A;                                                            
COMPND   8 SYNONYM: PRP8, N-TERMINAL DOMAIN;                                    
COMPND   9 MOL_ID: 3;                                                           
COMPND  10 MOLECULE: PRE-MRNA-SPLICING FACTOR SNU114;                           
COMPND  11 CHAIN: C;                                                            
COMPND  12 SYNONYM: 114 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT,GROWTH 
COMPND  13 INHIBITORY PROTEIN 10,SNU114;                                        
COMPND  14 OTHER_DETAILS: FULL LENGTH SNU114;                                   
COMPND  15 MOL_ID: 4;                                                           
COMPND  16 MOLECULE: U6 SNRNA, 5' END;                                          
COMPND  17 CHAIN: W;                                                            
COMPND  18 OTHER_DETAILS: THE 5' END 31 NUCLEOTIDES OF U6 SNRNA;                
COMPND  19 MOL_ID: 5;                                                           
COMPND  20 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B;      
COMPND  21 CHAIN: b;                                                            
COMPND  22 SYNONYM: SNRNP-B,SM PROTEIN B,SMB, U5 SMB;                           
COMPND  23 OTHER_DETAILS: THE SMB PROTEIN FROM THE U5 SNRNP SM PROTEIN RING.;   
COMPND  24 MOL_ID: 6;                                                           
COMPND  25 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN E;                         
COMPND  26 CHAIN: e;                                                            
COMPND  27 SYNONYM: SNRNP-E,SM PROTEIN E,SME, U5 SME;                           
COMPND  28 OTHER_DETAILS: THE SME PROTEIN FROM THE U5 SNRNP SM PROTEIN RING.;   
COMPND  29 MOL_ID: 7;                                                           
COMPND  30 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN F;                         
COMPND  31 CHAIN: f;                                                            
COMPND  32 SYNONYM: SNRNP-F,SM PROTEIN F,SMF;                                   
COMPND  33 OTHER_DETAILS: THE SMF PROTEIN FROM THE U5 SNRNP SM PROTEIN RING.;   
COMPND  34 MOL_ID: 8;                                                           
COMPND  35 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN G;                         
COMPND  36 CHAIN: g;                                                            
COMPND  37 SYNONYM: SNRNP-G,SM PROTEIN G,SMG;                                   
COMPND  38 OTHER_DETAILS: THE SMG PROTEIN FROM THE U5 SNRNP SM PROTEIN RING.;   
COMPND  39 MOL_ID: 9;                                                           
COMPND  40 MOLECULE: UNKNOWN POLYPEPTIDE;                                       
COMPND  41 CHAIN: x;                                                            
COMPND  42 MOL_ID: 10;                                                          
COMPND  43 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN SM D3;                     
COMPND  44 CHAIN: d;                                                            
COMPND  45 SYNONYM: SM-D3,SNRNP CORE PROTEIN D3, U5 SMD3;                       
COMPND  46 OTHER_DETAILS: THE SMD3 PROTEIN FROM THE U5 SNRNP SM PROTEIN RING.;  
COMPND  47 MOL_ID: 11;                                                          
COMPND  48 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN SM D1;                     
COMPND  49 CHAIN: h;                                                            
COMPND  50 SYNONYM: SM-D1,SNRNP CORE PROTEIN D1, U5 SMD1;                       
COMPND  51 OTHER_DETAILS: THE SMD1 PROTEIN FROM THE U5 SNRNP SM PROTEIN RING.;  
COMPND  52 MOL_ID: 12;                                                          
COMPND  53 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2;                     
COMPND  54 CHAIN: j;                                                            
COMPND  55 SYNONYM: SM-D2,SNRNP CORE PROTEIN D2, SMD2;                          
COMPND  56 OTHER_DETAILS: THE SMD2 PROTEIN FROM THE U5 SNRNP SM PROTEIN RING.   
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   3 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   4 ORGANISM_TAXID: 4932;                                                
SOURCE   5 STRAIN: BCY123;                                                      
SOURCE   6 MOL_ID: 2;                                                           
SOURCE   7 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   8 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   9 ORGANISM_TAXID: 4932;                                                
SOURCE  10 STRAIN: BCY123;                                                      
SOURCE  11 MOL_ID: 3;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  13 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  14 ORGANISM_TAXID: 4932;                                                
SOURCE  15 STRAIN: BCY123;                                                      
SOURCE  16 MOL_ID: 4;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  18 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  19 ORGANISM_TAXID: 4932;                                                
SOURCE  20 STRAIN: BCY123;                                                      
SOURCE  21 MOL_ID: 5;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  23 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  24 ORGANISM_TAXID: 4932;                                                
SOURCE  25 STRAIN: BCY123;                                                      
SOURCE  26 MOL_ID: 6;                                                           
SOURCE  27 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  28 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  29 ORGANISM_TAXID: 4932;                                                
SOURCE  30 STRAIN: BCY123;                                                      
SOURCE  31 MOL_ID: 7;                                                           
SOURCE  32 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  33 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  34 ORGANISM_TAXID: 4932;                                                
SOURCE  35 STRAIN: BCY123;                                                      
SOURCE  36 MOL_ID: 8;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  38 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  39 ORGANISM_TAXID: 4932;                                                
SOURCE  40 STRAIN: BCY123;                                                      
SOURCE  41 MOL_ID: 9;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  43 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  44 ORGANISM_TAXID: 4932;                                                
SOURCE  45 STRAIN: BCY123;                                                      
SOURCE  46 MOL_ID: 10;                                                          
SOURCE  47 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  48 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  49 ORGANISM_TAXID: 4932;                                                
SOURCE  50 STRAIN: BCY123;                                                      
SOURCE  51 MOL_ID: 11;                                                          
SOURCE  52 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  53 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  54 ORGANISM_TAXID: 4932;                                                
SOURCE  55 STRAIN: BCY123;                                                      
SOURCE  56 MOL_ID: 12;                                                          
SOURCE  57 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  58 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  59 ORGANISM_TAXID: 4932;                                                
SOURCE  60 STRAIN: BCY123                                                       
KEYWDS    TRANSCRIPTION, PRE-MRNA SPLICING, SNRNP, GTPASE, U5 SNRNA, PRP8,      
KEYWDS   2 SPLICEOSOME                                                          
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    T.H.D.NGUYEN,W.P.GALEJ,X.C.BAI,C.OUBRIDGE,S.H.W.SCHERES,A.J.NEWMAN,   
AUTHOR   2 K.NAGAI                                                              
REVDAT   4   30-AUG-17 5GAM    1       REMARK LINK                              
REVDAT   3   12-OCT-16 5GAM    1                                                
REVDAT   2   09-MAR-16 5GAM    1       JRNL                                     
REVDAT   1   03-FEB-16 5GAM    0                                                
JRNL        AUTH   T.H.D.NGUYEN,W.P.GALEJ,X.C.BAI,C.OUBRIDGE,S.H.W.SCHERES,     
JRNL        AUTH 2 A.J.NEWMAN,K.NAGAI                                           
JRNL        TITL   CRYO-EM STRUCTURE OF THE YEAST U4/U6.U5 TRI-SNRNP AT 3.7     
JRNL        TITL 2 ANGSTROM RESOLUTION                                          
JRNL        REF    NATURE                        V. 530   298 2016              
JRNL        REFN                   ESSN 1476-4687                               
JRNL        PMID   26829225                                                     
JRNL        DOI    10.1038/NATURE16940                                          
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   T.H.D.NGUYEN,W.GALEJ,X.C.BAI,C.G.SAVVA,A.J.NEWMAN,           
REMARK   1  AUTH 2 S.H.W.SCHERES,K.NAGAI                                        
REMARK   1  TITL   THE ARCHITECTURE OF THE SPLICEOSOMAL U4/U6.U5 TRI-SNRNP.     
REMARK   1  REF    NATURE                        V. 523    47 2015              
REMARK   1  REFN                   ESSN 1476-4687                               
REMARK   1  PMID   26106855                                                     
REMARK   1  DOI    10.1038/NATURE14548                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.70 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION, DIGITALMICROGRAPH, CTFFIND,       
REMARK   3                            COOT, REFMAC, RELION, RELION, RELION,     
REMARK   3                            RELION                                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : RECIPROCAL                          
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.700                          
REMARK   3   NUMBER OF PARTICLES               : 140155                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING ONLY            
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5GAM COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 22-JAN-16.                  
REMARK 100 THE DEPOSITION ID IS D_1001300035.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : FOOT REGION OF THE YEAST          
REMARK 245                                    SPLICEOSOMAL U4/U6.U5 TRI-SNRNP   
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.20                              
REMARK 245   SAMPLE SUPPORT DETAILS         : GRIDS ARE MADE OF HOLEY CARBON,   
REMARK 245                                    CARBON-COATED AND GLOW            
REMARK 245                                    DISCHARGED IN N-AMYLAMINE.        
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.90                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 2477                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : 500.00                         
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3500.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.00                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 38.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 81000                          
REMARK 245   CALIBRATED MAGNIFICATION          : 35714                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC                
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 35960 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 107930 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -246.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: U, A, C, W, b, e, f, g, x, d,         
REMARK 350                    AND CHAINS: h, j                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465       A U     1                                                      
REMARK 465       A U     2                                                      
REMARK 465       G U     3                                                      
REMARK 465       C U    54                                                      
REMARK 465       U U    55                                                      
REMARK 465       U U    56                                                      
REMARK 465       U U    57                                                      
REMARK 465       U U    58                                                      
REMARK 465       A U    59                                                      
REMARK 465       U U    60                                                      
REMARK 465       U U    61                                                      
REMARK 465       U U   145                                                      
REMARK 465       C U   146                                                      
REMARK 465       C U   147                                                      
REMARK 465       G U   148                                                      
REMARK 465       U U   149                                                      
REMARK 465       U U   150                                                      
REMARK 465       A U   151                                                      
REMARK 465       C U   152                                                      
REMARK 465       U U   153                                                      
REMARK 465       G U   154                                                      
REMARK 465       U U   155                                                      
REMARK 465       G U   156                                                      
REMARK 465       G U   157                                                      
REMARK 465       G U   158                                                      
REMARK 465       C U   159                                                      
REMARK 465       U U   160                                                      
REMARK 465       U U   161                                                      
REMARK 465       G U   162                                                      
REMARK 465       C U   163                                                      
REMARK 465       C U   164                                                      
REMARK 465       A U   165                                                      
REMARK 465       G U   174                                                      
REMARK 465       G U   175                                                      
REMARK 465       A U   176                                                      
REMARK 465       A U   177                                                      
REMARK 465       C U   178                                                      
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     GLY A     3                                                      
REMARK 465     LEU A     4                                                      
REMARK 465     PRO A     5                                                      
REMARK 465     PRO A     6                                                      
REMARK 465     PRO A     7                                                      
REMARK 465     PRO A     8                                                      
REMARK 465     PRO A     9                                                      
REMARK 465     GLY A    10                                                      
REMARK 465     PHE A    11                                                      
REMARK 465     GLU A    12                                                      
REMARK 465     GLU A    13                                                      
REMARK 465     ASP A    14                                                      
REMARK 465     SER A    15                                                      
REMARK 465     ASP A    16                                                      
REMARK 465     LEU A    17                                                      
REMARK 465     ALA A    18                                                      
REMARK 465     LEU A    19                                                      
REMARK 465     PRO A    20                                                      
REMARK 465     PRO A    21                                                      
REMARK 465     PRO A    22                                                      
REMARK 465     PRO A    23                                                      
REMARK 465     PRO A    24                                                      
REMARK 465     PRO A    25                                                      
REMARK 465     PRO A    26                                                      
REMARK 465     PRO A    27                                                      
REMARK 465     GLY A    28                                                      
REMARK 465     TYR A    29                                                      
REMARK 465     GLU A    30                                                      
REMARK 465     ILE A    31                                                      
REMARK 465     GLU A    32                                                      
REMARK 465     GLU A    33                                                      
REMARK 465     LEU A    34                                                      
REMARK 465     ASP A    35                                                      
REMARK 465     ASN A    36                                                      
REMARK 465     PRO A    37                                                      
REMARK 465     MET A    38                                                      
REMARK 465     VAL A    39                                                      
REMARK 465     PRO A    40                                                      
REMARK 465     SER A    41                                                      
REMARK 465     SER A    42                                                      
REMARK 465     VAL A    43                                                      
REMARK 465     ASN A    44                                                      
REMARK 465     GLU A    45                                                      
REMARK 465     ASP A    46                                                      
REMARK 465     THR A    47                                                      
REMARK 465     PHE A    48                                                      
REMARK 465     LEU A    49                                                      
REMARK 465     PRO A    50                                                      
REMARK 465     PRO A    51                                                      
REMARK 465     PRO A    52                                                      
REMARK 465     PRO A    53                                                      
REMARK 465     PRO A    54                                                      
REMARK 465     PRO A    55                                                      
REMARK 465     PRO A    56                                                      
REMARK 465     SER A    57                                                      
REMARK 465     ASN A    58                                                      
REMARK 465     PHE A    59                                                      
REMARK 465     GLU A    60                                                      
REMARK 465     ILE A    61                                                      
REMARK 465     ASN A    62                                                      
REMARK 465     ALA A    63                                                      
REMARK 465     GLU A    64                                                      
REMARK 465     GLU A    65                                                      
REMARK 465     ILE A    66                                                      
REMARK 465     VAL A    67                                                      
REMARK 465     ASP A    68                                                      
REMARK 465     PHE A    69                                                      
REMARK 465     THR A    70                                                      
REMARK 465     LEU A    71                                                      
REMARK 465     PRO A    72                                                      
REMARK 465     PRO A    73                                                      
REMARK 465     PRO A    74                                                      
REMARK 465     PRO A    75                                                      
REMARK 465     PRO A    76                                                      
REMARK 465     PRO A    77                                                      
REMARK 465     PRO A    78                                                      
REMARK 465     GLY A    79                                                      
REMARK 465     LEU A    80                                                      
REMARK 465     ASP A    81                                                      
REMARK 465     GLU A    82                                                      
REMARK 465     LEU A    83                                                      
REMARK 465     GLU A    84                                                      
REMARK 465     THR A    85                                                      
REMARK 465     LYS A    86                                                      
REMARK 465     ALA A    87                                                      
REMARK 465     GLU A    88                                                      
REMARK 465     LYS A    89                                                      
REMARK 465     LYS A    90                                                      
REMARK 465     VAL A    91                                                      
REMARK 465     GLU A    92                                                      
REMARK 465     LEU A    93                                                      
REMARK 465     HIS A    94                                                      
REMARK 465     GLY A    95                                                      
REMARK 465     LYS A    96                                                      
REMARK 465     ARG A    97                                                      
REMARK 465     LYS A    98                                                      
REMARK 465     LEU A    99                                                      
REMARK 465     ASP A   100                                                      
REMARK 465     ILE A   101                                                      
REMARK 465     GLY A   102                                                      
REMARK 465     LYS A   103                                                      
REMARK 465     ASP A   104                                                      
REMARK 465     THR A   105                                                      
REMARK 465     PHE A   106                                                      
REMARK 465     VAL A   107                                                      
REMARK 465     THR A   108                                                      
REMARK 465     ARG A   109                                                      
REMARK 465     SER A   151                                                      
REMARK 465     LYS A   152                                                      
REMARK 465     MET A   153                                                      
REMARK 465     TYR A   154                                                      
REMARK 465     ASN A   429                                                      
REMARK 465     PRO A   430                                                      
REMARK 465     ILE A   431                                                      
REMARK 465     PRO A   432                                                      
REMARK 465     HIS A   433                                                      
REMARK 465     PHE A   434                                                      
REMARK 465     ILE A   435                                                      
REMARK 465     ASP A   436                                                      
REMARK 465     ASN A   437                                                      
REMARK 465     ASN A   438                                                      
REMARK 465     SER A   439                                                      
REMARK 465     SER A   440                                                      
REMARK 465     LEU A   441                                                      
REMARK 465     ASN A   442                                                      
REMARK 465     VAL A   443                                                      
REMARK 465     SER A   444                                                      
REMARK 465     ASN A   445                                                      
REMARK 465     THR A   446                                                      
REMARK 465     LYS A   447                                                      
REMARK 465     GLU A   448                                                      
REMARK 465     ASN A   449                                                      
REMARK 465     GLY A   450                                                      
REMARK 465     ASP A   451                                                      
REMARK 465     PHE A   452                                                      
REMARK 465     THR A   453                                                      
REMARK 465     LEU A   454                                                      
REMARK 465     PRO A   455                                                      
REMARK 465     GLU A   456                                                      
REMARK 465     ASP A   457                                                      
REMARK 465     MET C     1                                                      
REMARK 465     GLU C     2                                                      
REMARK 465     GLY C     3                                                      
REMARK 465     ASP C     4                                                      
REMARK 465     ASP C     5                                                      
REMARK 465     LEU C     6                                                      
REMARK 465     PHE C     7                                                      
REMARK 465     ASP C     8                                                      
REMARK 465     GLU C     9                                                      
REMARK 465     PHE C    10                                                      
REMARK 465     GLY C    11                                                      
REMARK 465     ASN C    12                                                      
REMARK 465     LEU C    13                                                      
REMARK 465     ILE C    14                                                      
REMARK 465     GLY C    15                                                      
REMARK 465     VAL C    16                                                      
REMARK 465     ASP C    17                                                      
REMARK 465     PRO C    18                                                      
REMARK 465     PHE C    19                                                      
REMARK 465     ASP C    20                                                      
REMARK 465     SER C    21                                                      
REMARK 465     ASP C    22                                                      
REMARK 465     GLU C    23                                                      
REMARK 465     GLU C    24                                                      
REMARK 465     GLU C    25                                                      
REMARK 465     SER C    26                                                      
REMARK 465     VAL C    27                                                      
REMARK 465     LEU C    28                                                      
REMARK 465     ASP C    29                                                      
REMARK 465     GLU C    30                                                      
REMARK 465     GLN C    31                                                      
REMARK 465     GLU C    32                                                      
REMARK 465     GLN C    33                                                      
REMARK 465     TYR C    34                                                      
REMARK 465     GLN C    35                                                      
REMARK 465     THR C    36                                                      
REMARK 465     ASN C    37                                                      
REMARK 465     THR C    38                                                      
REMARK 465     PHE C    39                                                      
REMARK 465     GLU C    40                                                      
REMARK 465     GLY C    41                                                      
REMARK 465     SER C    42                                                      
REMARK 465     GLY C    43                                                      
REMARK 465     ASN C    44                                                      
REMARK 465     ASN C    45                                                      
REMARK 465     ASN C    46                                                      
REMARK 465     GLU C    47                                                      
REMARK 465     ILE C    48                                                      
REMARK 465     GLU C    49                                                      
REMARK 465     SER C    50                                                      
REMARK 465     ARG C    51                                                      
REMARK 465     GLN C    52                                                      
REMARK 465     LEU C    53                                                      
REMARK 465     THR C    54                                                      
REMARK 465     SER C    55                                                      
REMARK 465     LEU C    56                                                      
REMARK 465     GLY C    57                                                      
REMARK 465     SER C    58                                                      
REMARK 465     LYS C    59                                                      
REMARK 465     LYS C    60                                                      
REMARK 465     GLU C    61                                                      
REMARK 465     LEU C    62                                                      
REMARK 465     GLY C    63                                                      
REMARK 465     ILE C    64                                                      
REMARK 465     SER C    65                                                      
REMARK 465     LEU C    66                                                      
REMARK 465     GLU C    67                                                      
REMARK 465     HIS C    68                                                      
REMARK 465     PRO C    69                                                      
REMARK 465     TYR C    70                                                      
REMARK 465     GLY C    71                                                      
REMARK 465     LYS C    72                                                      
REMARK 465     GLU C    73                                                      
REMARK 465     VAL C    74                                                      
REMARK 465     GLU C    75                                                      
REMARK 465     VAL C    76                                                      
REMARK 465     LEU C    77                                                      
REMARK 465     MET C    78                                                      
REMARK 465     GLU C    79                                                      
REMARK 465     THR C    80                                                      
REMARK 465     LYS C    81                                                      
REMARK 465     ASN C    82                                                      
REMARK 465     THR C    83                                                      
REMARK 465     GLN C    84                                                      
REMARK 465     SER C    85                                                      
REMARK 465     PRO C    86                                                      
REMARK 465     GLN C    87                                                      
REMARK 465     THR C    88                                                      
REMARK 465     PRO C    89                                                      
REMARK 465     LEU C    90                                                      
REMARK 465     VAL C    91                                                      
REMARK 465     GLU C    92                                                      
REMARK 465     PRO C    93                                                      
REMARK 465     VAL C    94                                                      
REMARK 465     THR C    95                                                      
REMARK 465     GLU C    96                                                      
REMARK 465     ARG C    97                                                      
REMARK 465     THR C    98                                                      
REMARK 465     LYS C    99                                                      
REMARK 465     LEU C   100                                                      
REMARK 465     GLN C   101                                                      
REMARK 465     SER C   519                                                      
REMARK 465     LYS C   520                                                      
REMARK 465     THR C   521                                                      
REMARK 465     GLU C   522                                                      
REMARK 465     THR C   523                                                      
REMARK 465     SER C   524                                                      
REMARK 465     ASN C   525                                                      
REMARK 465     GLU C   526                                                      
REMARK 465     ASP C   527                                                      
REMARK 465     GLU C   528                                                      
REMARK 465     ASP C   529                                                      
REMARK 465     SER C   694                                                      
REMARK 465     ILE C   695                                                      
REMARK 465     SER C   696                                                      
REMARK 465     ARG C   697                                                      
REMARK 465     LEU C   698                                                      
REMARK 465     GLY C   699                                                      
REMARK 465     GLU C   700                                                      
REMARK 465     GLU C   701                                                      
REMARK 465     ASN C   702                                                      
REMARK 465     LEU C   703                                                      
REMARK 465     PRO C   704                                                      
REMARK 465     GLY C   705                                                      
REMARK 465     LEU C   706                                                      
REMARK 465     ASN C   726                                                      
REMARK 465     THR C   727                                                      
REMARK 465     LEU C   728                                                      
REMARK 465     GLY C   729                                                      
REMARK 465     LYS C   730                                                      
REMARK 465     GLY C   731                                                      
REMARK 465     GLN C   732                                                      
REMARK 465     ASN C   733                                                      
REMARK 465     CYS C   734                                                      
REMARK 465     LEU C   735                                                      
REMARK 465     ASP C   736                                                      
REMARK 465     ILE C   737                                                      
REMARK 465     ASP C   738                                                      
REMARK 465     GLY C   739                                                      
REMARK 465     ILE C   740                                                      
REMARK 465     MET C   741                                                      
REMARK 465     ASP C   742                                                      
REMARK 465     ASN C   743                                                      
REMARK 465     ALA C   999                                                      
REMARK 465     GLN C  1000                                                      
REMARK 465     LEU C  1001                                                      
REMARK 465     ARG C  1002                                                      
REMARK 465     GLU C  1003                                                      
REMARK 465     ASN C  1004                                                      
REMARK 465     GLY C  1005                                                      
REMARK 465     LEU C  1006                                                      
REMARK 465     VAL C  1007                                                      
REMARK 465     PRO C  1008                                                      
REMARK 465       G W    10                                                      
REMARK 465       U W    11                                                      
REMARK 465       A W    12                                                      
REMARK 465       A W    13                                                      
REMARK 465       C W    14                                                      
REMARK 465       C W    15                                                      
REMARK 465     MET b     1                                                      
REMARK 465     SER b     2                                                      
REMARK 465     LYS b     3                                                      
REMARK 465     THR b    56                                                      
REMARK 465     GLN b    57                                                      
REMARK 465     LEU b    58                                                      
REMARK 465     ASP b    59                                                      
REMARK 465     LYS b    60                                                      
REMARK 465     LEU b    61                                                      
REMARK 465     ARG b    62                                                      
REMARK 465     PRO b    63                                                      
REMARK 465     ARG b    64                                                      
REMARK 465     LYS b    65                                                      
REMARK 465     ASP b    66                                                      
REMARK 465     SER b    67                                                      
REMARK 465     LYS b    68                                                      
REMARK 465     ASP b    69                                                      
REMARK 465     GLY b    70                                                      
REMARK 465     THR b    71                                                      
REMARK 465     THR b    72                                                      
REMARK 465     LEU b    73                                                      
REMARK 465     ASN b    74                                                      
REMARK 465     LEU b   103                                                      
REMARK 465     SER b   104                                                      
REMARK 465     LYS b   105                                                      
REMARK 465     LYS b   106                                                      
REMARK 465     GLU b   107                                                      
REMARK 465     ARG b   108                                                      
REMARK 465     LEU b   109                                                      
REMARK 465     VAL b   110                                                      
REMARK 465     ARG b   111                                                      
REMARK 465     ASP b   112                                                      
REMARK 465     LYS b   113                                                      
REMARK 465     LYS b   114                                                      
REMARK 465     GLU b   115                                                      
REMARK 465     LYS b   116                                                      
REMARK 465     LYS b   117                                                      
REMARK 465     GLN b   118                                                      
REMARK 465     ALA b   119                                                      
REMARK 465     GLN b   120                                                      
REMARK 465     LYS b   121                                                      
REMARK 465     GLN b   122                                                      
REMARK 465     THR b   123                                                      
REMARK 465     LYS b   124                                                      
REMARK 465     LEU b   125                                                      
REMARK 465     ARG b   126                                                      
REMARK 465     LYS b   127                                                      
REMARK 465     GLU b   128                                                      
REMARK 465     LYS b   129                                                      
REMARK 465     GLU b   130                                                      
REMARK 465     LYS b   131                                                      
REMARK 465     LYS b   132                                                      
REMARK 465     PRO b   133                                                      
REMARK 465     GLY b   134                                                      
REMARK 465     LYS b   135                                                      
REMARK 465     ILE b   136                                                      
REMARK 465     ALA b   137                                                      
REMARK 465     LYS b   138                                                      
REMARK 465     PRO b   139                                                      
REMARK 465     ASN b   140                                                      
REMARK 465     THR b   141                                                      
REMARK 465     ALA b   142                                                      
REMARK 465     ASN b   143                                                      
REMARK 465     ALA b   144                                                      
REMARK 465     LYS b   145                                                      
REMARK 465     HIS b   146                                                      
REMARK 465     THR b   147                                                      
REMARK 465     SER b   148                                                      
REMARK 465     SER b   149                                                      
REMARK 465     ASN b   150                                                      
REMARK 465     SER b   151                                                      
REMARK 465     ARG b   152                                                      
REMARK 465     GLU b   153                                                      
REMARK 465     ILE b   154                                                      
REMARK 465     ALA b   155                                                      
REMARK 465     GLN b   156                                                      
REMARK 465     PRO b   157                                                      
REMARK 465     SER b   158                                                      
REMARK 465     SER b   159                                                      
REMARK 465     SER b   160                                                      
REMARK 465     ARG b   161                                                      
REMARK 465     TYR b   162                                                      
REMARK 465     ASN b   163                                                      
REMARK 465     GLY b   164                                                      
REMARK 465     GLY b   165                                                      
REMARK 465     ASN b   166                                                      
REMARK 465     ASP b   167                                                      
REMARK 465     ASN b   168                                                      
REMARK 465     ILE b   169                                                      
REMARK 465     GLY b   170                                                      
REMARK 465     ALA b   171                                                      
REMARK 465     ASN b   172                                                      
REMARK 465     ARG b   173                                                      
REMARK 465     SER b   174                                                      
REMARK 465     ARG b   175                                                      
REMARK 465     PHE b   176                                                      
REMARK 465     ASN b   177                                                      
REMARK 465     ASN b   178                                                      
REMARK 465     GLU b   179                                                      
REMARK 465     ALA b   180                                                      
REMARK 465     PRO b   181                                                      
REMARK 465     PRO b   182                                                      
REMARK 465     GLN b   183                                                      
REMARK 465     THR b   184                                                      
REMARK 465     ARG b   185                                                      
REMARK 465     LYS b   186                                                      
REMARK 465     PHE b   187                                                      
REMARK 465     GLN b   188                                                      
REMARK 465     PRO b   189                                                      
REMARK 465     PRO b   190                                                      
REMARK 465     PRO b   191                                                      
REMARK 465     GLY b   192                                                      
REMARK 465     PHE b   193                                                      
REMARK 465     LYS b   194                                                      
REMARK 465     ARG b   195                                                      
REMARK 465     LYS b   196                                                      
REMARK 465     MET e     1                                                      
REMARK 465     SER e     2                                                      
REMARK 465     ASN e     3                                                      
REMARK 465     LYS e     4                                                      
REMARK 465     VAL e     5                                                      
REMARK 465     LYS e     6                                                      
REMARK 465     THR e     7                                                      
REMARK 465     LYS e     8                                                      
REMARK 465     ALA e     9                                                      
REMARK 465     ALA e    65                                                      
REMARK 465     ASP e    66                                                      
REMARK 465     GLY e    67                                                      
REMARK 465     LYS e    68                                                      
REMARK 465     GLU e    69                                                      
REMARK 465     ASP e    70                                                      
REMARK 465     VAL e    71                                                      
REMARK 465     GLU e    72                                                      
REMARK 465     ALA e    93                                                      
REMARK 465     ASP e    94                                                      
REMARK 465     MET f     1                                                      
REMARK 465     SER f     2                                                      
REMARK 465     GLU f     3                                                      
REMARK 465     SER f     4                                                      
REMARK 465     SER f     5                                                      
REMARK 465     ASP f     6                                                      
REMARK 465     ILE f     7                                                      
REMARK 465     SER f     8                                                      
REMARK 465     ALA f     9                                                      
REMARK 465     MET f    10                                                      
REMARK 465     GLN f    11                                                      
REMARK 465     LEU f    84                                                      
REMARK 465     PRO f    85                                                      
REMARK 465     ASN f    86                                                      
REMARK 465     MET g     1                                                      
REMARK 465     ASN g    47                                                      
REMARK 465     GLY g    48                                                      
REMARK 465     GLU g    49                                                      
REMARK 465     ASP g    50                                                      
REMARK 465     PRO g    51                                                      
REMARK 465     ALA g    52                                                      
REMARK 465     ILE g    77                                                      
REMARK 465     MET d     1                                                      
REMARK 465     THR d     2                                                      
REMARK 465     MET d     3                                                      
REMARK 465     LYS d    86                                                      
REMARK 465     ASN d    87                                                      
REMARK 465     SER d    88                                                      
REMARK 465     SER d    89                                                      
REMARK 465     ARG d    90                                                      
REMARK 465     PRO d    91                                                      
REMARK 465     MET d    92                                                      
REMARK 465     PRO d    93                                                      
REMARK 465     PRO d    94                                                      
REMARK 465     ILE d    95                                                      
REMARK 465     ARG d    96                                                      
REMARK 465     GLY d    97                                                      
REMARK 465     PRO d    98                                                      
REMARK 465     LYS d    99                                                      
REMARK 465     ARG d   100                                                      
REMARK 465     ARG d   101                                                      
REMARK 465     GLN h    49                                                      
REMARK 465     PRO h    50                                                      
REMARK 465     ARG h    51                                                      
REMARK 465     LEU h    52                                                      
REMARK 465     ASN h    53                                                      
REMARK 465     LYS h    54                                                      
REMARK 465     LEU h    55                                                      
REMARK 465     ASN h    56                                                      
REMARK 465     SER h    57                                                      
REMARK 465     ASN h    58                                                      
REMARK 465     GLY h    59                                                      
REMARK 465     ILE h    60                                                      
REMARK 465     ALA h    61                                                      
REMARK 465     MET h    62                                                      
REMARK 465     ALA h    63                                                      
REMARK 465     SER h    64                                                      
REMARK 465     LEU h    65                                                      
REMARK 465     TYR h    66                                                      
REMARK 465     LEU h    67                                                      
REMARK 465     THR h    68                                                      
REMARK 465     GLY h    69                                                      
REMARK 465     GLY h    70                                                      
REMARK 465     GLN h    71                                                      
REMARK 465     GLN h    72                                                      
REMARK 465     PRO h    73                                                      
REMARK 465     THR h    74                                                      
REMARK 465     ALA h    75                                                      
REMARK 465     GLN h   110                                                      
REMARK 465     LYS h   111                                                      
REMARK 465     GLN h   112                                                      
REMARK 465     LEU h   113                                                      
REMARK 465     ASN h   114                                                      
REMARK 465     SER h   115                                                      
REMARK 465     LEU h   116                                                      
REMARK 465     ARG h   117                                                      
REMARK 465     ARG h   118                                                      
REMARK 465     SER h   119                                                      
REMARK 465     GLY h   120                                                      
REMARK 465     GLN h   121                                                      
REMARK 465     ILE h   122                                                      
REMARK 465     ALA h   123                                                      
REMARK 465     ASN h   124                                                      
REMARK 465     ASP h   125                                                      
REMARK 465     PRO h   126                                                      
REMARK 465     SER h   127                                                      
REMARK 465     LYS h   128                                                      
REMARK 465     LYS h   129                                                      
REMARK 465     ARG h   130                                                      
REMARK 465     ARG h   131                                                      
REMARK 465     ARG h   132                                                      
REMARK 465     ASP h   133                                                      
REMARK 465     PHE h   134                                                      
REMARK 465     GLY h   135                                                      
REMARK 465     ALA h   136                                                      
REMARK 465     PRO h   137                                                      
REMARK 465     ALA h   138                                                      
REMARK 465     ASN h   139                                                      
REMARK 465     LYS h   140                                                      
REMARK 465     ARG h   141                                                      
REMARK 465     PRO h   142                                                      
REMARK 465     ARG h   143                                                      
REMARK 465     ARG h   144                                                      
REMARK 465     GLY h   145                                                      
REMARK 465     LEU h   146                                                      
REMARK 465     MET j     1                                                      
REMARK 465     SER j     2                                                      
REMARK 465     SER j     3                                                      
REMARK 465     GLN j     4                                                      
REMARK 465     ILE j     5                                                      
REMARK 465     ILE j     6                                                      
REMARK 465     ASP j     7                                                      
REMARK 465     ARG j     8                                                      
REMARK 465     PRO j     9                                                      
REMARK 465     LYS j    10                                                      
REMARK 465     HIS j    11                                                      
REMARK 465     GLU j    12                                                      
REMARK 465     LEU j    13                                                      
REMARK 465     SER j    14                                                      
REMARK 465     VAL j   109                                                      
REMARK 465     GLU j   110                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A 110    CG   CD   CE   NZ                                   
REMARK 470     ARG A 112    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 113    CG   CD   CE   NZ                                   
REMARK 470     ARG A 114    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 117    CG   CD   CE   NZ                                   
REMARK 470     MET A 118    CG   SD   CE                                        
REMARK 470     LYS A 120    CG   CD   CE   NZ                                   
REMARK 470     LYS A 121    CG   CD   CE   NZ                                   
REMARK 470     LYS A 123    CG   CD   CE   NZ                                   
REMARK 470     ASP A 148    CG   OD1  OD2                                       
REMARK 470     MET A 149    CG   SD   CE                                        
REMARK 470     ASP A 157    CG   OD1  OD2                                       
REMARK 470     LYS A 158    CG   CD   CE   NZ                                   
REMARK 470     LYS A 159    CG   CD   CE   NZ                                   
REMARK 470     GLU A 227    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 230    CG   OD1  OD2                                       
REMARK 470     ARG A 231    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS A 233    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS A 235    CG   CD   CE   NZ                                   
REMARK 470     ARG A 236    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP A 243    CG   OD1  OD2                                       
REMARK 470     ASP A 244    CG   OD1  OD2                                       
REMARK 470     ASP A 245    CG   OD1  OD2                                       
REMARK 470     GLU A 246    CG   CD   OE1  OE2                                  
REMARK 470     ILE A 258    CG1  CG2  CD1                                       
REMARK 470     GLU A 259    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 262    CG   OD1  OD2                                       
REMARK 470     GLU A 274    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 291    CG   CD   CE   NZ                                   
REMARK 470     GLU A 321    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 358    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 359    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 360    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 361    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 362    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 363    CG   OD1  OD2                                       
REMARK 470     GLU A 366    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 413    CG   OD1  ND2                                       
REMARK 470     GLU A 415    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 464    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 465    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 508    CG   CD   OE1  NE2                                  
REMARK 470     GLU A 512    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 513    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 546    CG   CD   CE   NZ                                   
REMARK 470     LYS A 549    CG   CD   CE   NZ                                   
REMARK 470     LYS A 552    CG   CD   CE   NZ                                   
REMARK 470     ASN A 553    CG   OD1  ND2                                       
REMARK 470     LYS A 555    CG   CD   CE   NZ                                   
REMARK 470     PHE A 557    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU A 566    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 573    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 586    CG   CD   CE   NZ                                   
REMARK 470     LYS A 603    CG   CD   CE   NZ                                   
REMARK 470     LYS A 608    CG   CD   CE   NZ                                   
REMARK 470     GLU A 609    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 611    CG   CD   CE   NZ                                   
REMARK 470     LYS A 612    CG   CD   CE   NZ                                   
REMARK 470     GLU A 624    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 732    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN A 733    CG   CD   OE1  NE2                                  
REMARK 470     PHE A 734    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU A 735    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 102    CG   CD   OE1  OE2                                  
REMARK 470     HIS C 103    CG   ND1  CD2  CE1  NE2                             
REMARK 470     THR C 104    OG1  CG2                                            
REMARK 470     ASN C 119    CG   OD1  ND2                                       
REMARK 470     ASP C 121    CG   OD1  OD2                                       
REMARK 470     MET C 123    CG   SD   CE                                        
REMARK 470     ASN C 128    CG   OD1  ND2                                       
REMARK 470     GLU C 131    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 151    CG   OD1  OD2                                       
REMARK 470     LYS C 166    CG   CD   CE   NZ                                   
REMARK 470     ASN C 167    CG   OD1  ND2                                       
REMARK 470     GLU C 169    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 184    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 186    CG   OD1  OD2                                       
REMARK 470     ASP C 214    CG   OD1  OD2                                       
REMARK 470     GLU C 224    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 243    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 271    CG   OD1  OD2                                       
REMARK 470     ASP C 276    CG   OD1  OD2                                       
REMARK 470     PHE C 298    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS C 300    CG   CD   CE   NZ                                   
REMARK 470     LYS C 325    CG   CD   CE   NZ                                   
REMARK 470     GLU C 326    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 340    CG   CD   CE   NZ                                   
REMARK 470     LYS C 362    CG   CD   CE   NZ                                   
REMARK 470     GLU C 365    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 368    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 369    CG   CD   CE   NZ                                   
REMARK 470     GLU C 375    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 383    CG   CD   CE   NZ                                   
REMARK 470     MET C 391    CG   SD   CE                                        
REMARK 470     GLU C 392    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 393    CG   CD   CE   NZ                                   
REMARK 470     ASP C 394    CG   OD1  OD2                                       
REMARK 470     ARG C 405    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP C 437    CG   OD1  OD2                                       
REMARK 470     LYS C 461    CG   CD   CE   NZ                                   
REMARK 470     GLU C 465    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 477    CG   OD1  OD2                                       
REMARK 470     GLU C 482    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 503    CG   OD1  OD2                                       
REMARK 470     GLU C 508    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 512    CG   CD   CE   NZ                                   
REMARK 470     LYS C 531    CG   CD   CE   NZ                                   
REMARK 470     THR C 532    OG1  CG2                                            
REMARK 470     GLU C 533    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 541    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 555    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 558    CG   CD   CE   NZ                                   
REMARK 470     LYS C 581    CG   CD   CE   NZ                                   
REMARK 470     LYS C 583    CG   CD   CE   NZ                                   
REMARK 470     GLU C 584    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 585    CG   OD1  OD2                                       
REMARK 470     LYS C 587    CG   CD   CE   NZ                                   
REMARK 470     GLN C 588    CG   CD   OE1  NE2                                  
REMARK 470     LYS C 665    CG   CD   CE   NZ                                   
REMARK 470     GLU C 667    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 672    CG   OD1  OD2                                       
REMARK 470     GLU C 679    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 713    CG   CD   OE1  OE2                                  
REMARK 470     MET C 715    CG   SD   CE                                        
REMARK 470     ASP C 716    CG   OD1  OD2                                       
REMARK 470     LYS C 718    CG   CD   CE   NZ                                   
REMARK 470     ASP C 722    CG   OD1  OD2                                       
REMARK 470     ARG C 745    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 746    CG   CD   CE   NZ                                   
REMARK 470     LYS C 749    CG   CD   CE   NZ                                   
REMARK 470     ARG C 752    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 754    CG   CD   OE1  OE2                                  
REMARK 470     TRP C 757    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP C 757    CZ3  CH2                                            
REMARK 470     ARG C 763    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP C 766    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP C 766    CZ3  CH2                                            
REMARK 470     LEU C 779    CG   CD1  CD2                                       
REMARK 470     LYS C 792    CG   CD   CE   NZ                                   
REMARK 470     GLU C 793    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 804    CG   CD   CE   NZ                                   
REMARK 470     GLU C 805    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 810    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 811    CG   CD   OE1  OE2                                  
REMARK 470     GLN C 817    CG   CD   OE1  NE2                                  
REMARK 470     GLN C 837    CG   CD   OE1  NE2                                  
REMARK 470     GLU C 859    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 863    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 877    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 878    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 901    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 910    CG   CD   OE1  OE2                                  
REMARK 470     MET C 927    CG   SD   CE                                        
REMARK 470     LYS C 935    CG   CD   CE   NZ                                   
REMARK 470     ASP C 948    CG   OD1  OD2                                       
REMARK 470     LEU C 989    CG   CD1  CD2                                       
REMARK 470     GLU C 990    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 991    CG   CD   CE   NZ                                   
REMARK 470     TYR C 992    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE C 993    CG1  CG2  CD1                                       
REMARK 470     SER C 994    OG                                                  
REMARK 470     GLU C 996    CG   CD   OE1  OE2                                  
REMARK 470     LEU C 997    CG   CD1  CD2                                       
REMARK 470     TYR C 998    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS b  55    CG   CD   CE   NZ                                   
REMARK 470     GLU b  98    CG   CD   OE1  OE2                                  
REMARK 470     ASP b  99    CG   OD1  OD2                                       
REMARK 470     GLU e  56    CG   CD   OE1  OE2                                  
REMARK 470     GLU e  59    CG   CD   OE1  OE2                                  
REMARK 470     LYS e  73    CG   CD   CE   NZ                                   
REMARK 470     GLU f  37    CG   CD   OE1  OE2                                  
REMARK 470     GLU g   6    CG   CD   OE1  OE2                                  
REMARK 470     ASP g  42    CG   OD1  OD2                                       
REMARK 470     GLU d  13    CG   CD   OE1  OE2                                  
REMARK 470     ASP d  46    CG   OD1  OD2                                       
REMARK 470     GLU j  19    CG   CD   OE1  OE2                                  
REMARK 470     GLU j  20    CG   CD   OE1  OE2                                  
REMARK 470     GLU j  22    CG   CD   OE1  OE2                                  
REMARK 470     GLU j  23    CG   CD   OE1  OE2                                  
REMARK 470     GLU j  25    CG   CD   OE1  OE2                                  
REMARK 470     ASP j  36    CG   OD1  OD2                                       
REMARK 470     GLU j  74    CG   CD   OE1  OE2                                  
REMARK 470     GLU j  88    CG   CD   OE1  OE2                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O2'    U U    74     OP2    U U    76              1.98            
REMARK 500   CD1  LEU A   139     CD2  TYR A   193              2.15            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500      A U  82   C2' -  C3' -  O3' ANGL. DEV. =  11.4 DEGREES          
REMARK 500      A U 128   C2' -  C3' -  O3' ANGL. DEV. =  10.7 DEGREES          
REMARK 500    PRO C 812   C   -  N   -  CA  ANGL. DEV. =   9.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER A 125       83.38     60.19                                   
REMARK 500    ASN A 178       40.48    -86.74                                   
REMARK 500    ASN A 203      -61.51    -97.22                                   
REMARK 500    THR A 232      -64.79    -96.96                                   
REMARK 500    PRO A 247       52.74   -115.29                                   
REMARK 500    TYR A 251      -62.58   -143.28                                   
REMARK 500    GLU A 256       47.35   -105.43                                   
REMARK 500    PRO A 260      105.02    -49.69                                   
REMARK 500    ASP A 262       98.77    -11.82                                   
REMARK 500    PRO A 263     -179.03    -69.32                                   
REMARK 500    ASP A 273       62.37   -103.42                                   
REMARK 500    LEU A 286     -161.99    -68.36                                   
REMARK 500    SER A 290     -164.21   -115.50                                   
REMARK 500    LEU A 318      -70.07    -79.80                                   
REMARK 500    ARG A 319       74.08   -101.40                                   
REMARK 500    THR A 323       46.80   -100.39                                   
REMARK 500    LEU A 355      -36.29     74.35                                   
REMARK 500    GLU A 360      -89.77    -75.99                                   
REMARK 500    TYR A 364       69.11     33.82                                   
REMARK 500    LEU A 390      -60.52    -98.50                                   
REMARK 500    ARG A 394       72.28     55.92                                   
REMARK 500    TYR A 403       23.96   -160.36                                   
REMARK 500    ASN A 404      171.25    -49.30                                   
REMARK 500    ASP A 418       64.00     66.54                                   
REMARK 500    PRO A 426      177.86    -51.83                                   
REMARK 500    SER A 482     -177.95    -69.07                                   
REMARK 500    ASN A 487      -18.34    -48.71                                   
REMARK 500    ALA A 496      -28.07     70.33                                   
REMARK 500    VAL A 499       69.10     64.24                                   
REMARK 500    GLN A 508       48.22    -99.69                                   
REMARK 500    HIS A 509       69.29     33.07                                   
REMARK 500    GLU A 512      108.38   -163.39                                   
REMARK 500    ASN A 541      132.39    -32.61                                   
REMARK 500    LEU A 551      -70.18    -71.04                                   
REMARK 500    GLN A 559       60.91     33.27                                   
REMARK 500    ASN A 596       39.11    -85.86                                   
REMARK 500    PHE A 597       -8.85     60.66                                   
REMARK 500    ASN A 598       95.03    -67.42                                   
REMARK 500    LYS A 603     -178.83   -172.21                                   
REMARK 500    THR A 604       68.62     64.36                                   
REMARK 500    LEU A 615     -161.32     43.70                                   
REMARK 500    ASN A 692       49.08    -96.83                                   
REMARK 500    CYS A 701      113.96   -165.74                                   
REMARK 500    PHE A 703       66.58     61.60                                   
REMARK 500    GLU C 131       -5.02     67.33                                   
REMARK 500    MET C 164       96.18    -63.06                                   
REMARK 500    TRP C 172      -83.82    -80.03                                   
REMARK 500    LEU C 175       75.80     58.59                                   
REMARK 500    ASN C 180      -92.71     62.25                                   
REMARK 500    GLU C 204       95.37     68.22                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     123 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 PRO A  460     LEU A  461                 -129.76                    
REMARK 500 GLU A  464     GLU A  465                  124.34                    
REMARK 500 GLU A  466     GLU A  467                  148.64                    
REMARK 500 ASN A  553     THR A  554                  111.89                    
REMARK 500 TYR A  556     PHE A  557                  138.06                    
REMARK 500 THR C  498     VAL C  499                 -148.57                    
REMARK 500 LEU C  607     GLN C  608                  148.21                    
REMARK 500 GLU C  811     PRO C  812                 -148.60                    
REMARK 500 PRO C  958     ILE C  959                 -147.32                    
REMARK 500 ASP g   41     ASP g   42                 -147.18                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GTP C 1101                
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8011   RELATED DB: EMDB                              
DBREF1 5GAM U    1   178  GB                   CP011085.1                       
DBREF2 5GAM U     807071959                      909079      908902             
DBREF  5GAM A    1   735  UNP    P33334   PRP8_YEAST       1    735             
DBREF  5GAM C    1  1008  UNP    P36048   SN114_YEAST      1   1008             
DBREF  5GAM W    1    31  PDB    5GAM     5GAM             1     31             
DBREF  5GAM b    1   196  UNP    P40018   RSMB_YEAST       1    196             
DBREF  5GAM e    1    94  UNP    Q12330   RUXE_YEAST       1     94             
DBREF  5GAM f    1    86  UNP    P54999   RUXF_YEAST       1     86             
DBREF  5GAM g    1    77  UNP    P40204   RUXG_YEAST       1     77             
DBREF  5GAM x  201   218  PDB    5GAM     5GAM           201    218             
DBREF  5GAM d    1   101  UNP    P43321   SMD3_YEAST       1    101             
DBREF  5GAM h    1   146  UNP    Q02260   SMD1_YEAST       1    146             
DBREF  5GAM j    1   110  UNP    Q06217   SMD2_YEAST       1    110             
SEQADV 5GAM SER C  530  UNP  P36048    GLU   530 CONFLICT                       
SEQADV 5GAM LYS C  531  UNP  P36048    ASP   531 CONFLICT                       
SEQADV 5GAM THR C  532  UNP  P36048    ASP   532 CONFLICT                       
SEQRES   1 U  178    A   A   G   C   A   G   C   U   U   U   A   C   A          
SEQRES   2 U  178    G   A   U   C   A   A   U   G   G   C   G   G   A          
SEQRES   3 U  178    G   G   G   A   G   G   U   C   A   A   C   A   U          
SEQRES   4 U  178    C   A   A   G   A   A   C   U   G   U   G   G   G          
SEQRES   5 U  178    C   C   U   U   U   U   A   U   U   G   C   C   U          
SEQRES   6 U  178    A   U   A   G   A   A   C   U   U   A   U   A   A          
SEQRES   7 U  178    C   G   A   A   C   A   U   G   G   U   U   C   U          
SEQRES   8 U  178    U   G   C   C   U   U   U   U   A   C   C   A   G          
SEQRES   9 U  178    A   A   C   C   A   U   C   C   G   G   G   U   G          
SEQRES  10 U  178    U   U   G   U   C   U   C   C   A   U   A   G   A          
SEQRES  11 U  178    A   A   C   A   G   G   U   A   A   A   G   C   U          
SEQRES  12 U  178    G   U   C   C   G   U   U   A   C   U   G   U   G          
SEQRES  13 U  178    G   G   C   U   U   G   C   C   A   U   A   U   U          
SEQRES  14 U  178    U   U   U   U   G   G   A   A   C                          
SEQRES   1 A  735  MET SER GLY LEU PRO PRO PRO PRO PRO GLY PHE GLU GLU          
SEQRES   2 A  735  ASP SER ASP LEU ALA LEU PRO PRO PRO PRO PRO PRO PRO          
SEQRES   3 A  735  PRO GLY TYR GLU ILE GLU GLU LEU ASP ASN PRO MET VAL          
SEQRES   4 A  735  PRO SER SER VAL ASN GLU ASP THR PHE LEU PRO PRO PRO          
SEQRES   5 A  735  PRO PRO PRO PRO SER ASN PHE GLU ILE ASN ALA GLU GLU          
SEQRES   6 A  735  ILE VAL ASP PHE THR LEU PRO PRO PRO PRO PRO PRO PRO          
SEQRES   7 A  735  GLY LEU ASP GLU LEU GLU THR LYS ALA GLU LYS LYS VAL          
SEQRES   8 A  735  GLU LEU HIS GLY LYS ARG LYS LEU ASP ILE GLY LYS ASP          
SEQRES   9 A  735  THR PHE VAL THR ARG LYS SER ARG LYS ARG ALA LYS LYS          
SEQRES  10 A  735  MET THR LYS LYS ALA LYS ARG SER ASN LEU TYR THR PRO          
SEQRES  11 A  735  LYS ALA GLU MET PRO PRO GLU HIS LEU ARG LYS ILE ILE          
SEQRES  12 A  735  ASN THR HIS SER ASP MET ALA SER LYS MET TYR ASN THR          
SEQRES  13 A  735  ASP LYS LYS ALA PHE LEU GLY ALA LEU LYS TYR LEU PRO          
SEQRES  14 A  735  HIS ALA ILE LEU LYS LEU LEU GLU ASN MET PRO HIS PRO          
SEQRES  15 A  735  TRP GLU GLN ALA LYS GLU VAL LYS VAL LEU TYR HIS THR          
SEQRES  16 A  735  SER GLY ALA ILE THR PHE VAL ASN GLU THR PRO ARG VAL          
SEQRES  17 A  735  ILE GLU PRO VAL TYR THR ALA GLN TRP SER ALA THR TRP          
SEQRES  18 A  735  ILE ALA MET ARG ARG GLU LYS ARG ASP ARG THR HIS PHE          
SEQRES  19 A  735  LYS ARG MET ARG PHE PRO PRO PHE ASP ASP ASP GLU PRO          
SEQRES  20 A  735  PRO LEU SER TYR GLU GLN HIS ILE GLU ASN ILE GLU PRO          
SEQRES  21 A  735  LEU ASP PRO ILE ASN LEU PRO LEU ASP SER GLN ASP ASP          
SEQRES  22 A  735  GLU TYR VAL LYS ASP TRP LEU TYR ASP SER ARG PRO LEU          
SEQRES  23 A  735  GLU GLU ASP SER LYS LYS VAL ASN GLY THR SER TYR LYS          
SEQRES  24 A  735  LYS TRP SER PHE ASP LEU PRO GLU MET SER ASN LEU TYR          
SEQRES  25 A  735  ARG LEU SER THR PRO LEU ARG ASP GLU VAL THR ASP LYS          
SEQRES  26 A  735  ASN TYR TYR TYR LEU PHE ASP LYS LYS SER PHE PHE ASN          
SEQRES  27 A  735  GLY LYS ALA LEU ASN ASN ALA ILE PRO GLY GLY PRO LYS          
SEQRES  28 A  735  PHE GLU PRO LEU TYR PRO ARG GLU GLU GLU GLU ASP TYR          
SEQRES  29 A  735  ASN GLU PHE ASN SER ILE ASP ARG VAL ILE PHE ARG VAL          
SEQRES  30 A  735  PRO ILE ARG SER GLU TYR LYS VAL ALA PHE PRO HIS LEU          
SEQRES  31 A  735  TYR ASN SER ARG PRO ARG SER VAL ARG ILE PRO TRP TYR          
SEQRES  32 A  735  ASN ASN PRO VAL SER CYS ILE ILE GLN ASN ASP GLU GLU          
SEQRES  33 A  735  TYR ASP THR PRO ALA LEU PHE PHE ASP PRO SER LEU ASN          
SEQRES  34 A  735  PRO ILE PRO HIS PHE ILE ASP ASN ASN SER SER LEU ASN          
SEQRES  35 A  735  VAL SER ASN THR LYS GLU ASN GLY ASP PHE THR LEU PRO          
SEQRES  36 A  735  GLU ASP PHE ALA PRO LEU LEU ALA GLU GLU GLU GLU LEU          
SEQRES  37 A  735  ILE LEU PRO ASN THR LYS ASP ALA MET SER LEU TYR HIS          
SEQRES  38 A  735  SER PRO PHE PRO PHE ASN ARG THR LYS GLY LYS MET VAL          
SEQRES  39 A  735  ARG ALA GLN ASP VAL ALA LEU ALA LYS LYS TRP PHE LEU          
SEQRES  40 A  735  GLN HIS PRO ASP GLU GLU TYR PRO VAL LYS VAL LYS VAL          
SEQRES  41 A  735  SER TYR GLN LYS LEU LEU LYS ASN TYR VAL LEU ASN GLU          
SEQRES  42 A  735  LEU HIS PRO THR LEU PRO THR ASN HIS ASN LYS THR LYS          
SEQRES  43 A  735  LEU LEU LYS SER LEU LYS ASN THR LYS TYR PHE GLN GLN          
SEQRES  44 A  735  THR THR ILE ASP TRP VAL GLU ALA GLY LEU GLN LEU CYS          
SEQRES  45 A  735  ARG GLN GLY HIS ASN MET LEU ASN LEU LEU ILE HIS ARG          
SEQRES  46 A  735  LYS GLY LEU THR TYR LEU HIS LEU ASP TYR ASN PHE ASN          
SEQRES  47 A  735  LEU LYS PRO THR LYS THR LEU THR THR LYS GLU ARG LYS          
SEQRES  48 A  735  LYS SER ARG LEU GLY ASN SER PHE HIS LEU MET ARG GLU          
SEQRES  49 A  735  LEU LEU LYS MET MET LYS LEU ILE VAL ASP THR HIS VAL          
SEQRES  50 A  735  GLN PHE ARG LEU GLY ASN VAL ASP ALA PHE GLN LEU ALA          
SEQRES  51 A  735  ASP GLY ILE HIS TYR ILE LEU ASN HIS ILE GLY GLN LEU          
SEQRES  52 A  735  THR GLY ILE TYR ARG TYR LYS TYR LYS VAL MET HIS GLN          
SEQRES  53 A  735  ILE ARG ALA CYS LYS ASP LEU LYS HIS ILE ILE TYR TYR          
SEQRES  54 A  735  LYS PHE ASN LYS ASN LEU GLY LYS GLY PRO GLY CYS GLY          
SEQRES  55 A  735  PHE TRP GLN PRO ALA TRP ARG VAL TRP LEU ASN PHE LEU          
SEQRES  56 A  735  ARG GLY THR ILE PRO LEU LEU GLU ARG TYR ILE GLY ASN          
SEQRES  57 A  735  LEU ILE THR ARG GLN PHE GLU                                  
SEQRES   1 C 1008  MET GLU GLY ASP ASP LEU PHE ASP GLU PHE GLY ASN LEU          
SEQRES   2 C 1008  ILE GLY VAL ASP PRO PHE ASP SER ASP GLU GLU GLU SER          
SEQRES   3 C 1008  VAL LEU ASP GLU GLN GLU GLN TYR GLN THR ASN THR PHE          
SEQRES   4 C 1008  GLU GLY SER GLY ASN ASN ASN GLU ILE GLU SER ARG GLN          
SEQRES   5 C 1008  LEU THR SER LEU GLY SER LYS LYS GLU LEU GLY ILE SER          
SEQRES   6 C 1008  LEU GLU HIS PRO TYR GLY LYS GLU VAL GLU VAL LEU MET          
SEQRES   7 C 1008  GLU THR LYS ASN THR GLN SER PRO GLN THR PRO LEU VAL          
SEQRES   8 C 1008  GLU PRO VAL THR GLU ARG THR LYS LEU GLN GLU HIS THR          
SEQRES   9 C 1008  ILE PHE THR GLN LEU LYS LYS ASN ILE PRO LYS THR ARG          
SEQRES  10 C 1008  TYR ASN ARG ASP TYR MET LEU SER MET ALA ASN ILE PRO          
SEQRES  11 C 1008  GLU ARG ILE ILE ASN VAL GLY VAL ILE GLY PRO LEU HIS          
SEQRES  12 C 1008  SER GLY LYS THR SER LEU MET ASP LEU LEU VAL ILE ASP          
SEQRES  13 C 1008  SER HIS LYS ARG ILE PRO ASP MET SER LYS ASN VAL GLU          
SEQRES  14 C 1008  LEU GLY TRP LYS PRO LEU ARG TYR LEU ASP ASN LEU LYS          
SEQRES  15 C 1008  GLN GLU ILE ASP ARG GLY LEU SER ILE LYS LEU ASN GLY          
SEQRES  16 C 1008  SER THR LEU LEU CYS THR ASP LEU GLU SER LYS SER ARG          
SEQRES  17 C 1008  MET ILE ASN PHE LEU ASP ALA PRO GLY HIS VAL ASN PHE          
SEQRES  18 C 1008  MET ASP GLU THR ALA VAL ALA LEU ALA ALA SER ASP LEU          
SEQRES  19 C 1008  VAL LEU ILE VAL ILE ASP VAL VAL GLU GLY VAL THR PHE          
SEQRES  20 C 1008  VAL VAL GLU GLN LEU ILE LYS GLN SER ILE LYS ASN ASN          
SEQRES  21 C 1008  VAL ALA MET CYS PHE VAL ILE ASN LYS LEU ASP ARG LEU          
SEQRES  22 C 1008  ILE LEU ASP LEU LYS LEU PRO PRO MET ASP ALA TYR LEU          
SEQRES  23 C 1008  LYS LEU ASN HIS ILE ILE ALA ASN ILE ASN SER PHE THR          
SEQRES  24 C 1008  LYS GLY ASN VAL PHE SER PRO ILE ASP ASN ASN ILE ILE          
SEQRES  25 C 1008  PHE ALA SER THR LYS LEU GLY PHE THR PHE THR ILE LYS          
SEQRES  26 C 1008  GLU PHE VAL SER TYR TYR TYR ALA HIS SER ILE PRO SER          
SEQRES  27 C 1008  SER LYS ILE ASP ASP PHE THR THR ARG LEU TRP GLY SER          
SEQRES  28 C 1008  VAL TYR TYR HIS LYS GLY ASN PHE ARG THR LYS PRO PHE          
SEQRES  29 C 1008  GLU ASN VAL GLU LYS TYR PRO THR PHE VAL GLU PHE ILE          
SEQRES  30 C 1008  LEU ILE PRO LEU TYR LYS ILE PHE SER TYR ALA LEU SER          
SEQRES  31 C 1008  MET GLU LYS ASP LYS LEU LYS ASN LEU LEU ARG SER ASN          
SEQRES  32 C 1008  PHE ARG VAL ASN LEU SER GLN GLU ALA LEU GLN TYR ASP          
SEQRES  33 C 1008  PRO GLN PRO PHE LEU LYS HIS VAL LEU GLN LEU ILE PHE          
SEQRES  34 C 1008  ARG GLN GLN THR GLY LEU VAL ASP ALA ILE THR ARG CYS          
SEQRES  35 C 1008  TYR GLN PRO PHE GLU LEU PHE ASP ASN LYS THR ALA HIS          
SEQRES  36 C 1008  LEU SER ILE PRO GLY LYS SER THR PRO GLU GLY THR LEU          
SEQRES  37 C 1008  TRP ALA HIS VAL LEU LYS THR VAL ASP TYR GLY GLY ALA          
SEQRES  38 C 1008  GLU TRP SER LEU VAL ARG ILE TYR SER GLY LEU LEU LYS          
SEQRES  39 C 1008  ARG GLY ASP THR VAL ARG ILE LEU ASP THR SER GLN SER          
SEQRES  40 C 1008  GLU SER ARG GLN LYS ARG GLN LEU HIS ASP ILE SER LYS          
SEQRES  41 C 1008  THR GLU THR SER ASN GLU ASP GLU ASP SER LYS THR GLU          
SEQRES  42 C 1008  THR PRO SER CYS GLU VAL GLU GLU ILE GLY LEU LEU GLY          
SEQRES  43 C 1008  GLY ARG TYR VAL TYR PRO VAL HIS GLU ALA HIS LYS GLY          
SEQRES  44 C 1008  GLN ILE VAL LEU ILE LYS GLY ILE SER SER ALA TYR ILE          
SEQRES  45 C 1008  LYS SER ALA THR LEU TYR SER VAL LYS SER LYS GLU ASP          
SEQRES  46 C 1008  MET LYS GLN LEU LYS PHE PHE LYS PRO LEU ASP TYR ILE          
SEQRES  47 C 1008  THR GLU ALA VAL PHE LYS ILE VAL LEU GLN PRO LEU LEU          
SEQRES  48 C 1008  PRO ARG GLU LEU PRO LYS LEU LEU ASP ALA LEU ASN LYS          
SEQRES  49 C 1008  ILE SER LYS TYR TYR PRO GLY VAL ILE ILE LYS VAL GLU          
SEQRES  50 C 1008  GLU SER GLY GLU HIS VAL ILE LEU GLY ASN GLY GLU LEU          
SEQRES  51 C 1008  TYR MET ASP CYS LEU LEU TYR ASP LEU ARG ALA SER TYR          
SEQRES  52 C 1008  ALA LYS ILE GLU ILE LYS ILE SER ASP PRO LEU THR VAL          
SEQRES  53 C 1008  PHE SER GLU SER CYS SER ASN GLU SER PHE ALA SER ILE          
SEQRES  54 C 1008  PRO VAL SER ASN SER ILE SER ARG LEU GLY GLU GLU ASN          
SEQRES  55 C 1008  LEU PRO GLY LEU SER ILE SER VAL ALA ALA GLU PRO MET          
SEQRES  56 C 1008  ASP SER LYS MET ILE GLN ASP LEU SER ARG ASN THR LEU          
SEQRES  57 C 1008  GLY LYS GLY GLN ASN CYS LEU ASP ILE ASP GLY ILE MET          
SEQRES  58 C 1008  ASP ASN PRO ARG LYS LEU SER LYS ILE LEU ARG THR GLU          
SEQRES  59 C 1008  TYR GLY TRP ASP SER LEU ALA SER ARG ASN VAL TRP SER          
SEQRES  60 C 1008  PHE TYR ASN GLY ASN VAL LEU ILE ASN ASP THR LEU PRO          
SEQRES  61 C 1008  ASP GLU ILE SER PRO GLU LEU LEU SER LYS TYR LYS GLU          
SEQRES  62 C 1008  GLN ILE ILE GLN GLY PHE TYR TRP ALA VAL LYS GLU GLY          
SEQRES  63 C 1008  PRO LEU ALA GLU GLU PRO ILE TYR GLY VAL GLN TYR LYS          
SEQRES  64 C 1008  LEU LEU SER ILE SER VAL PRO SER ASP VAL ASN ILE ASP          
SEQRES  65 C 1008  VAL MET LYS SER GLN ILE ILE PRO LEU MET LYS LYS ALA          
SEQRES  66 C 1008  CYS TYR VAL GLY LEU LEU THR ALA ILE PRO ILE LEU LEU          
SEQRES  67 C 1008  GLU PRO ILE TYR GLU VAL ASP ILE THR VAL HIS ALA PRO          
SEQRES  68 C 1008  LEU LEU PRO ILE VAL GLU GLU LEU MET LYS LYS ARG ARG          
SEQRES  69 C 1008  GLY SER ARG ILE TYR LYS THR ILE LYS VAL ALA GLY THR          
SEQRES  70 C 1008  PRO LEU LEU GLU VAL ARG GLY GLN VAL PRO VAL ILE GLU          
SEQRES  71 C 1008  SER ALA GLY PHE GLU THR ASP LEU ARG LEU SER THR ASN          
SEQRES  72 C 1008  GLY LEU GLY MET CYS GLN LEU TYR PHE TRP HIS LYS ILE          
SEQRES  73 C 1008  TRP ARG LYS VAL PRO GLY ASP VAL LEU ASP LYS ASP ALA          
SEQRES  74 C 1008  PHE ILE PRO LYS LEU LYS PRO ALA PRO ILE ASN SER LEU          
SEQRES  75 C 1008  SER ARG ASP PHE VAL MET LYS THR ARG ARG ARG LYS GLY          
SEQRES  76 C 1008  ILE SER THR GLY GLY PHE MET SER ASN ASP GLY PRO THR          
SEQRES  77 C 1008  LEU GLU LYS TYR ILE SER ALA GLU LEU TYR ALA GLN LEU          
SEQRES  78 C 1008  ARG GLU ASN GLY LEU VAL PRO                                  
SEQRES   1 W   31    G   U   U   C   G   C   G   A   A   G   U   A   A          
SEQRES   2 W   31    C   C   C   U   U   C   G   U   G   G   A   C   A          
SEQRES   3 W   31    U   U   U   G   G                                          
SEQRES   1 b  196  MET SER LYS ILE GLN VAL ALA HIS SER SER ARG LEU ALA          
SEQRES   2 b  196  ASN LEU ILE ASP TYR LYS LEU ARG VAL LEU THR GLN ASP          
SEQRES   3 b  196  GLY ARG VAL TYR ILE GLY GLN LEU MET ALA PHE ASP LYS          
SEQRES   4 b  196  HIS MET ASN LEU VAL LEU ASN GLU CYS ILE GLU GLU ARG          
SEQRES   5 b  196  VAL PRO LYS THR GLN LEU ASP LYS LEU ARG PRO ARG LYS          
SEQRES   6 b  196  ASP SER LYS ASP GLY THR THR LEU ASN ILE LYS VAL GLU          
SEQRES   7 b  196  LYS ARG VAL LEU GLY LEU THR ILE LEU ARG GLY GLU GLN          
SEQRES   8 b  196  ILE LEU SER THR VAL VAL GLU ASP LYS PRO LEU LEU SER          
SEQRES   9 b  196  LYS LYS GLU ARG LEU VAL ARG ASP LYS LYS GLU LYS LYS          
SEQRES  10 b  196  GLN ALA GLN LYS GLN THR LYS LEU ARG LYS GLU LYS GLU          
SEQRES  11 b  196  LYS LYS PRO GLY LYS ILE ALA LYS PRO ASN THR ALA ASN          
SEQRES  12 b  196  ALA LYS HIS THR SER SER ASN SER ARG GLU ILE ALA GLN          
SEQRES  13 b  196  PRO SER SER SER ARG TYR ASN GLY GLY ASN ASP ASN ILE          
SEQRES  14 b  196  GLY ALA ASN ARG SER ARG PHE ASN ASN GLU ALA PRO PRO          
SEQRES  15 b  196  GLN THR ARG LYS PHE GLN PRO PRO PRO GLY PHE LYS ARG          
SEQRES  16 b  196  LYS                                                          
SEQRES   1 e   94  MET SER ASN LYS VAL LYS THR LYS ALA MET VAL PRO PRO          
SEQRES   2 e   94  ILE ASN CYS ILE PHE ASN PHE LEU GLN GLN GLN THR PRO          
SEQRES   3 e   94  VAL THR ILE TRP LEU PHE GLU GLN ILE GLY ILE ARG ILE          
SEQRES   4 e   94  LYS GLY LYS ILE VAL GLY PHE ASP GLU PHE MET ASN VAL          
SEQRES   5 e   94  VAL ILE ASP GLU ALA VAL GLU ILE PRO VAL ASN SER ALA          
SEQRES   6 e   94  ASP GLY LYS GLU ASP VAL GLU LYS GLY THR PRO LEU GLY          
SEQRES   7 e   94  LYS ILE LEU LEU LYS GLY ASP ASN ILE THR LEU ILE THR          
SEQRES   8 e   94  SER ALA ASP                                                  
SEQRES   1 f   86  MET SER GLU SER SER ASP ILE SER ALA MET GLN PRO VAL          
SEQRES   2 f   86  ASN PRO LYS PRO PHE LEU LYS GLY LEU VAL ASN HIS ARG          
SEQRES   3 f   86  VAL GLY VAL LYS LEU LYS PHE ASN SER THR GLU TYR ARG          
SEQRES   4 f   86  GLY THR LEU VAL SER THR ASP ASN TYR PHE ASN LEU GLN          
SEQRES   5 f   86  LEU ASN GLU ALA GLU GLU PHE VAL ALA GLY VAL SER HIS          
SEQRES   6 f   86  GLY THR LEU GLY GLU ILE PHE ILE ARG CYS ASN ASN VAL          
SEQRES   7 f   86  LEU TYR ILE ARG GLU LEU PRO ASN                              
SEQRES   1 g   77  MET VAL SER THR PRO GLU LEU LYS LYS TYR MET ASP LYS          
SEQRES   2 g   77  LYS ILE LEU LEU ASN ILE ASN GLY SER ARG LYS VAL ALA          
SEQRES   3 g   77  GLY ILE LEU ARG GLY TYR ASP ILE PHE LEU ASN VAL VAL          
SEQRES   4 g   77  LEU ASP ASP ALA MET GLU ILE ASN GLY GLU ASP PRO ALA          
SEQRES   5 g   77  ASN ASN HIS GLN LEU GLY LEU GLN THR VAL ILE ARG GLY          
SEQRES   6 g   77  ASN SER ILE ILE SER LEU GLU ALA LEU ASP ALA ILE              
SEQRES   1 x   18  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   2 x   18  UNK UNK UNK UNK UNK                                          
SEQRES   1 d  101  MET THR MET ASN GLY ILE PRO VAL LYS LEU LEU ASN GLU          
SEQRES   2 d  101  ALA GLN GLY HIS ILE VAL SER LEU GLU LEU THR THR GLY          
SEQRES   3 d  101  ALA THR TYR ARG GLY LYS LEU VAL GLU SER GLU ASP SER          
SEQRES   4 d  101  MET ASN VAL GLN LEU ARG ASP VAL ILE ALA THR GLU PRO          
SEQRES   5 d  101  GLN GLY ALA VAL THR HIS MET ASP GLN ILE PHE VAL ARG          
SEQRES   6 d  101  GLY SER GLN ILE LYS PHE ILE VAL VAL PRO ASP LEU LEU          
SEQRES   7 d  101  LYS ASN ALA PRO LEU PHE LYS LYS ASN SER SER ARG PRO          
SEQRES   8 d  101  MET PRO PRO ILE ARG GLY PRO LYS ARG ARG                      
SEQRES   1 h  146  MET LYS LEU VAL ASN PHE LEU LYS LYS LEU ARG ASN GLU          
SEQRES   2 h  146  GLN VAL THR ILE GLU LEU LYS ASN GLY THR THR VAL TRP          
SEQRES   3 h  146  GLY THR LEU GLN SER VAL SER PRO GLN MET ASN ALA ILE          
SEQRES   4 h  146  LEU THR ASP VAL LYS LEU THR LEU PRO GLN PRO ARG LEU          
SEQRES   5 h  146  ASN LYS LEU ASN SER ASN GLY ILE ALA MET ALA SER LEU          
SEQRES   6 h  146  TYR LEU THR GLY GLY GLN GLN PRO THR ALA SER ASP ASN          
SEQRES   7 h  146  ILE ALA SER LEU GLN TYR ILE ASN ILE ARG GLY ASN THR          
SEQRES   8 h  146  ILE ARG GLN ILE ILE LEU PRO ASP SER LEU ASN LEU ASP          
SEQRES   9 h  146  SER LEU LEU VAL ASP GLN LYS GLN LEU ASN SER LEU ARG          
SEQRES  10 h  146  ARG SER GLY GLN ILE ALA ASN ASP PRO SER LYS LYS ARG          
SEQRES  11 h  146  ARG ARG ASP PHE GLY ALA PRO ALA ASN LYS ARG PRO ARG          
SEQRES  12 h  146  ARG GLY LEU                                                  
SEQRES   1 j  110  MET SER SER GLN ILE ILE ASP ARG PRO LYS HIS GLU LEU          
SEQRES   2 j  110  SER ARG ALA GLU LEU GLU GLU LEU GLU GLU PHE GLU PHE          
SEQRES   3 j  110  LYS HIS GLY PRO MET SER LEU ILE ASN ASP ALA MET VAL          
SEQRES   4 j  110  THR ARG THR PRO VAL ILE ILE SER LEU ARG ASN ASN HIS          
SEQRES   5 j  110  LYS ILE ILE ALA ARG VAL LYS ALA PHE ASP ARG HIS CYS          
SEQRES   6 j  110  ASN MET VAL LEU GLU ASN VAL LYS GLU LEU TRP THR GLU          
SEQRES   7 j  110  LYS LYS GLY LYS ASN VAL ILE ASN ARG GLU ARG PHE ILE          
SEQRES   8 j  110  SER LYS LEU PHE LEU ARG GLY ASP SER VAL ILE VAL VAL          
SEQRES   9 j  110  LEU LYS THR PRO VAL GLU                                      
HET    GTP  C1101      32                                                       
HETNAM     GTP GUANOSINE-5'-TRIPHOSPHATE                                        
FORMUL  13  GTP    C10 H16 N5 O14 P3                                            
HELIX    1 AA1 LYS A  110  ARG A  124  1                                  15    
HELIX    2 AA2 PRO A  135  ALA A  150  1                                  16    
HELIX    3 AA3 LYS A  158  LYS A  166  1                                   9    
HELIX    4 AA4 TYR A  167  ASN A  178  1                                  12    
HELIX    5 AA5 ILE A  209  ARG A  231  1                                  23    
HELIX    6 AA6 TYR A  251  GLU A  256  1                                   6    
HELIX    7 AA7 ASP A  304  THR A  316  1                                  13    
HELIX    8 AA8 ASP A  324  TYR A  329  5                                   6    
HELIX    9 AA9 ASP A  332  ALA A  341  1                                  10    
HELIX   10 AB1 ARG A  380  PHE A  387  1                                   8    
HELIX   11 AB2 ASN A  472  SER A  482  1                                  11    
HELIX   12 AB3 PRO A  483  ARG A  488  1                                   6    
HELIX   13 AB4 ALA A  502  LEU A  507  1                                   6    
HELIX   14 AB5 PRO A  515  HIS A  535  1                                  21    
HELIX   15 AB6 LYS A  544  ASN A  553  1                                  10    
HELIX   16 AB7 TRP A  564  LYS A  586  1                                  23    
HELIX   17 AB8 THR A  606  SER A  613  1                                   8    
HELIX   18 AB9 GLY A  616  LEU A  641  1                                  26    
HELIX   19 AC1 ASP A  645  HIS A  659  1                                  15    
HELIX   20 AC2 HIS A  659  THR A  664  1                                   6    
HELIX   21 AC3 TYR A  671  ASN A  692  1                                  22    
HELIX   22 AC4 TRP A  704  THR A  731  1                                  28    
HELIX   23 AC5 HIS C  103  ASN C  112  1                                  10    
HELIX   24 AC6 ASN C  119  ASN C  128  1                                  10    
HELIX   25 AC7 LYS C  146  HIS C  158  1                                  13    
HELIX   26 AC8 SER C  165  GLY C  171  1                                   7    
HELIX   27 AC9 LEU C  181  GLY C  188  1                                   8    
HELIX   28 AD1 HIS C  218  ASN C  220  5                                   3    
HELIX   29 AD2 PHE C  221  SER C  232  1                                  12    
HELIX   30 AD3 THR C  246  LYS C  258  1                                  13    
HELIX   31 AD4 LYS C  269  ASP C  276  1                                   8    
HELIX   32 AD5 PRO C  280  THR C  299  1                                  20    
HELIX   33 AD6 THR C  323  TYR C  332  1                                  10    
HELIX   34 AD7 PRO C  337  SER C  339  5                                   3    
HELIX   35 AD8 LYS C  340  TRP C  349  1                                  10    
HELIX   36 AD9 PRO C  371  ILE C  377  1                                   7    
HELIX   37 AE1 ILE C  377  SER C  390  1                                  14    
HELIX   38 AE2 GLU C  392  ASN C  403  1                                  12    
HELIX   39 AE3 SER C  409  GLN C  414  1                                   6    
HELIX   40 AE4 ASP C  416  PHE C  429  1                                  14    
HELIX   41 AE5 GLN C  432  TYR C  443  1                                  12    
HELIX   42 AE6 PHE C  446  ILE C  458  1                                  13    
HELIX   43 AE7 SER C  507  ILE C  518  1                                  12    
HELIX   44 AE8 LYS C  583  LEU C  589  1                                   7    
HELIX   45 AE9 LEU C  611  ARG C  613  5                                   3    
HELIX   46 AF1 GLU C  614  TYR C  629  1                                  16    
HELIX   47 AF2 GLY C  648  SER C  662  1                                  15    
HELIX   48 AF3 ASP C  716  ARG C  725  1                                  10    
HELIX   49 AF4 ARG C  745  TRP C  757  1                                  13    
HELIX   50 AF5 SER C  759  TRP C  766  1                                   8    
HELIX   51 AF6 TYR C  791  GLU C  805  1                                  15    
HELIX   52 AF7 ASN C  830  ALA C  853  1                                  24    
HELIX   53 AF8 LEU C  872  ARG C  883  1                                  12    
HELIX   54 AF9 VAL C  908  ALA C  912  1                                   5    
HELIX   55 AG1 GLY C  913  THR C  922  1                                  10    
HELIX   56 AG2 PRO C  958  GLY C  975  1                                  18    
HELIX   57 AG3 LEU C  989  TYR C  998  1                                  10    
HELIX   58 AG4 LEU b   12  ILE b   16  5                                   5    
HELIX   59 AG5 PRO e   12  GLN e   24  1                                  13    
HELIX   60 AG6 GLY e   84  ILE e   87  5                                   4    
HELIX   61 AG7 ASN f   14  LEU f   22  1                                   9    
HELIX   62 AG8 UNK x  202  UNK x  218  1                                  17    
HELIX   63 AG9 GLY d    5  GLN d   15  1                                  11    
HELIX   64 AH1 ARG d   65  SER d   67  5                                   3    
HELIX   65 AH2 PRO d   75  ASN d   80  5                                   6    
HELIX   66 AH3 LYS h    2  LEU h   10  1                                   9    
HELIX   67 AH4 ASN h  102  LEU h  107  1                                   6    
HELIX   68 AH5 ALA j   16  GLY j   29  1                                  14    
HELIX   69 AH6 MET j   31  ARG j   41  1                                  11    
SHEET    1  AA 2 GLU A 188  VAL A 189  0                                        
SHEET    2  AA 2 ILE A 562  ASP A 563 -1                                        
SHEET    1  AB 2 VAL A 191  LEU A 192  0                                        
SHEET    2  AB 2 PHE A 201  VAL A 202 -1                                        
SHEET    1  AC 2 LYS A 300  SER A 302  0                                        
SHEET    2  AC 2 LYS A 490  LYS A 492 -1                                        
SHEET    1  AD 2 HIS A 592  LEU A 593  0                                        
SHEET    2  AD 2 LEU A 599  LYS A 600 -1                                        
SHEET    1  CA 7 SER C 196  LEU C 199  0                                        
SHEET    2  CA 7 MET C 209  ASP C 214 -1                                        
SHEET    3  CA 7 ASN C 135  ILE C 139  1                                        
SHEET    4  CA 7 LEU C 234  ASP C 240  1                                        
SHEET    5  CA 7 ALA C 262  ASN C 268  1                                        
SHEET    6  CA 7 PHE C 313  SER C 315  1                                        
SHEET    7  CA 7 PHE C 320  PHE C 322 -1                                        
SHEET    1  CB 7 CYS C 537  GLU C 538  0                                        
SHEET    2  CB 7 THR C 498  ASP C 503 -1                                        
SHEET    3  CB 7 ALA C 575  TYR C 578 -1                                        
SHEET    4  CB 7 TRP C 469  VAL C 476 -1                                        
SHEET    5  CB 7 TRP C 483  SER C 490 -1                                        
SHEET    6  CB 7 ILE C 561  ILE C 564 -1                                        
SHEET    7  CB 7 ILE C 542  GLY C 543 -1                                        
SHEET    1  CC 2 LEU C 492  LYS C 494  0                                        
SHEET    2  CC 2 GLU C 555  HIS C 557 -1                                        
SHEET    1  CD 4 ILE C 633  VAL C 636  0                                        
SHEET    2  CD 4 HIS C 642  GLY C 646 -1                                        
SHEET    3  CD 4 PHE C 603  PRO C 609 -1                                        
SHEET    4  CD 4 ILE C 668  ILE C 670 -1                                        
SHEET    1  CE 4 ILE C 633  VAL C 636  0                                        
SHEET    2  CE 4 HIS C 642  GLY C 646 -1                                        
SHEET    3  CE 4 PHE C 603  PRO C 609 -1                                        
SHEET    4  CE 4 LEU C 674  THR C 675 -1                                        
SHEET    1  CF 2 ILE C 668  ILE C 670  0                                        
SHEET    2  CF 2 PHE C 603  PRO C 609 -1                                        
SHEET    1  CG 2 SER C 678  CYS C 681  0                                        
SHEET    2  CG 2 PRO C 855  HIS C 869 -1                                        
SHEET    1  CH 4 ILE C 892  LYS C 893  0                                        
SHEET    2  CH 4 LEU C 899  GLU C 901 -1                                        
SHEET    3  CH 4 PRO C 855  HIS C 869  1                                        
SHEET    4  CH 4 CYS C 928  TYR C 931  1                                        
SHEET    1  CI 4 ILE C 892  LYS C 893  0                                        
SHEET    2  CI 4 LEU C 899  GLU C 901 -1                                        
SHEET    3  CI 4 PRO C 855  HIS C 869  1                                        
SHEET    4  CI 4 GLN C 905  PRO C 907  1                                        
SHEET    1  CJ 2 CYS C 928  TYR C 931  0                                        
SHEET    2  CJ 2 PRO C 855  HIS C 869  1                                        
SHEET    1  CK 4 ILE C 892  LYS C 893  0                                        
SHEET    2  CK 4 LEU C 899  GLU C 901 -1                                        
SHEET    3  CK 4 PRO C 855  HIS C 869  1                                        
SHEET    4  CK 4 TRP C 937  LYS C 939  1                                        
SHEET    1  CL 3 ILE C 708  GLU C 713  0                                        
SHEET    2  CL 3 VAL C 816  ILE C 823 -1                                        
SHEET    3  CL 3 LEU C 774  THR C 778  1                                        
SHEET    1  DA15 VAL d  56  VAL d  64  0                                        
SHEET    2  DA15 VAL d  42  THR d  50 -1                                        
SHEET    3  DA15 TYR d  29  GLU d  35 -1                                        
SHEET    4  DA15 ILE d  18  LEU d  23 -1                                        
SHEET    5  DA15 ILE d  69  VAL d  74 -1                                        
SHEET    6  DA15 GLU b  78  LEU b  87 -1                                        
SHEET    7  DA15 LEU b  43  ARG b  52 -1                                        
SHEET    8  DA15 VAL b  29  ALA b  36 -1                                        
SHEET    9  DA15 LYS b  19  THR b  24 -1                                        
SHEET   10  DA15 ILE b  92  VAL b  97 -1                                        
SHEET   11  DA15 ALA h  80  ILE h  87 -1                                        
SHEET   12  DA15 ALA h  38  THR h  46 -1                                        
SHEET   13  DA15 THR h  24  VAL h  32 -1                                        
SHEET   14  DA15 GLU h  13  LEU h  19 -1                                        
SHEET   15  DA15 ILE h  92  ILE h  96 -1                                        
SHEET    1  EA14 VAL e  27  LEU e  31  0                                        
SHEET    2  EA14 GLN e  34  ILE e  43 -1                                        
SHEET    3  EA14 VAL e  52  PRO e  61 -1                                        
SHEET    4  EA14 ILE e  80  LEU e  82 -1                                        
SHEET    5  EA14 VAL f  78  ARG f  82 -1                                        
SHEET    6  EA14 ARG f  26  LEU f  31 -1                                        
SHEET    7  EA14 GLU f  37  THR f  45 -1                                        
SHEET    8  EA14 LEU f  51  PHE f  59 -1                                        
SHEET    9  EA14 SER f  64  ILE f  73 -1                                        
SHEET   10  EA14 VAL j 101  LYS j 106 -1                                        
SHEET   11  EA14 PRO j  43  LEU j  48 -1                                        
SHEET   12  EA14 LYS j  53  VAL j  58 -1                                        
SHEET   13  EA14 MET j  67  TRP j  76 -1                                        
SHEET   14  EA14 ARG j  87  LEU j  96 -1                                        
SHEET    1  EB 4 LEU e  89  ILE e  90  0                                        
SHEET    2  EB 4 GLN g  60  ILE g  63 -1                                        
SHEET    3  EB 4 VAL g  38  ASP g  41 -1                                        
SHEET    4  EB 4 ILE g  28  TYR g  32 -1                                        
SHEET    1  GA 3 ARG g  23  VAL g  25  0                                        
SHEET    2  GA 3 ILE g  15  ILE g  19 -1                                        
SHEET    3  GA 3 ILE g  68  ALA g  73 -1                                        
SHEET    1  GB 2 MET g  44  GLU g  45  0                                        
SHEET    2  GB 2 HIS g  55  GLN g  56 -1                                        
CISPEP   1 PHE A  239    PRO A  240          0        -4.28                     
CISPEP   2 ARG A  284    PRO A  285          0         2.50                     
CISPEP   3 THR A  554    LYS A  555          0        28.63                     
CISPEP   4 ASN C  259    ASN C  260          0         6.33                     
CISPEP   5 ASN C  358    PHE C  359          0         9.98                     
CISPEP   6 ARG C  360    THR C  361          0        18.77                     
CISPEP   7 PHE C  364    GLU C  365          0       -11.36                     
CISPEP   8 GLN C  444    PRO C  445          0        -4.55                     
CISPEP   9 LEU C  545    GLY C  546          0         2.76                     
CISPEP  10 ASN C  772    VAL C  773          0        18.65                     
CISPEP  11 PRO C  987    THR C  988          0        10.42                     
CISPEP  12 THR C  988    LEU C  989          0        -2.03                     
CISPEP  13 ALA d   81    PRO d   82          0        -0.72                     
CISPEP  14 GLY j   81    LYS j   82          0        -0.24                     
SITE     1 AC1 14 LEU C 142  HIS C 143  GLY C 145  LYS C 146                    
SITE     2 AC1 14 THR C 147  SER C 148  LEU C 189  SER C 190                    
SITE     3 AC1 14 ALA C 215  GLY C 217  LYS C 269  SER C 315                    
SITE     4 AC1 14 THR C 316  LYS C 317                                          
CRYST1  543.400  543.400  543.400  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.001840  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.001840  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.001840        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system