GenomeNet

Database: PDB
Entry: 5GAN
LinkDB: 5GAN
Original site: 5GAN 
HEADER    TRANSCRIPTION                           15-DEC-15   5GAN              
TITLE     THE OVERALL STRUCTURE OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP AT 
TITLE    2 3.7 ANGSTROM                                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: U4 SNRNA;                                                  
COMPND   3 CHAIN: V;                                                            
COMPND   4 SYNONYM: U4 SNRNA;                                                   
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: U6 SNRNA;                                                  
COMPND   7 CHAIN: W;                                                            
COMPND   8 SYNONYM: U6 SNRNA;                                                   
COMPND   9 MOL_ID: 3;                                                           
COMPND  10 MOLECULE: PRE-MRNA-SPLICING FACTOR 8;                                
COMPND  11 CHAIN: A;                                                            
COMPND  12 SYNONYM: PRP8;                                                       
COMPND  13 MOL_ID: 4;                                                           
COMPND  14 MOLECULE: U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4;                
COMPND  15 CHAIN: H;                                                            
COMPND  16 SYNONYM: PRE-MRNA-PROCESSING PROTEIN 4, PRP4;                        
COMPND  17 MOL_ID: 5;                                                           
COMPND  18 MOLECULE: PRE-MRNA-SPLICING FACTOR 6;                                
COMPND  19 CHAIN: J;                                                            
COMPND  20 SYNONYM: PRP6;                                                       
COMPND  21 MOL_ID: 6;                                                           
COMPND  22 MOLECULE: SPLICEOSOMAL PROTEIN DIB1;                                 
COMPND  23 CHAIN: D;                                                            
COMPND  24 MOL_ID: 7;                                                           
COMPND  25 MOLECULE: PRE-MRNA-PROCESSING FACTOR 31;                             
COMPND  26 CHAIN: F;                                                            
COMPND  27 SYNONYM: PRP31;                                                      
COMPND  28 MOL_ID: 8;                                                           
COMPND  29 MOLECULE: U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3;                
COMPND  30 CHAIN: G;                                                            
COMPND  31 SYNONYM: PRE-MRNA-SPLICING FACTOR 3, PRP3;                           
COMPND  32 MOL_ID: 9;                                                           
COMPND  33 MOLECULE: PRE-MRNA-SPLICING HELICASE BRR2;                           
COMPND  34 CHAIN: B;                                                            
COMPND  35 SYNONYM: PROTEIN SNU246, BRR2;                                       
COMPND  36 EC: 3.6.4.13;                                                        
COMPND  37 MOL_ID: 10;                                                          
COMPND  38 MOLECULE: UNKNOWN PROTEIN;                                           
COMPND  39 CHAIN: x;                                                            
COMPND  40 MOL_ID: 11;                                                          
COMPND  41 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B;      
COMPND  42 CHAIN: k, b;                                                         
COMPND  43 SYNONYM: SNRNP-B,SM PROTEIN B,SMB;                                   
COMPND  44 MOL_ID: 12;                                                          
COMPND  45 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN SM D1;                     
COMPND  46 CHAIN: l, h;                                                         
COMPND  47 SYNONYM: SM-D1,SNRNP CORE PROTEIN D1, U4 SMD1;                       
COMPND  48 MOL_ID: 13;                                                          
COMPND  49 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2;                     
COMPND  50 CHAIN: m, j;                                                         
COMPND  51 SYNONYM: SM-D2,SNRNP CORE PROTEIN D2, SMD2;                          
COMPND  52 MOL_ID: 14;                                                          
COMPND  53 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN SM D3;                     
COMPND  54 CHAIN: n, d;                                                         
COMPND  55 SYNONYM: SM-D3,SNRNP CORE PROTEIN D3, SMD3;                          
COMPND  56 MOL_ID: 15;                                                          
COMPND  57 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN E;                         
COMPND  58 CHAIN: p, e;                                                         
COMPND  59 SYNONYM: SNRNP-E,SM PROTEIN E,SME;                                   
COMPND  60 MOL_ID: 16;                                                          
COMPND  61 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN F;                         
COMPND  62 CHAIN: q, f;                                                         
COMPND  63 SYNONYM: SNRNP-F,SM PROTEIN F,SMF;                                   
COMPND  64 MOL_ID: 17;                                                          
COMPND  65 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN G;                         
COMPND  66 CHAIN: r, g;                                                         
COMPND  67 SYNONYM: SNRNP-G,SM PROTEIN G,SMG;                                   
COMPND  68 MOL_ID: 18;                                                          
COMPND  69 MOLECULE: SNU66;                                                     
COMPND  70 CHAIN: E;                                                            
COMPND  71 OTHER_DETAILS: SNU66 IS MOSTLY FITTED AS POLYALA INTO HELICES AND    
COMPND  72 EXTENDED POLYPEPTIDES WITHIN THE EM MAP. THE AUTHORS DO NOT BELIEVE  
COMPND  73 THAT THE SEQUENCE NUMBER IS CORRECT.;                                
COMPND  74 MOL_ID: 19;                                                          
COMPND  75 MOLECULE: U5 SNRNA;                                                  
COMPND  76 CHAIN: U;                                                            
COMPND  77 MOL_ID: 20;                                                          
COMPND  78 MOLECULE: 13 KDA RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN;               
COMPND  79 CHAIN: K;                                                            
COMPND  80 SYNONYM: SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN 1, SNU13;
COMPND  81 MOL_ID: 21;                                                          
COMPND  82 MOLECULE: U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2;                  
COMPND  83 CHAIN: 2;                                                            
COMPND  84 SYNONYM: SMALL NUCLEAR RIBONUCLEOPROTEIN D HOMOLOG SNP3;             
COMPND  85 MOL_ID: 22;                                                          
COMPND  86 MOLECULE: U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3;                  
COMPND  87 CHAIN: 3;                                                            
COMPND  88 SYNONYM: SMX4 PROTEIN;                                               
COMPND  89 MOL_ID: 23;                                                          
COMPND  90 MOLECULE: U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM4;                  
COMPND  91 CHAIN: 4;                                                            
COMPND  92 SYNONYM: LSM4;                                                       
COMPND  93 MOL_ID: 24;                                                          
COMPND  94 MOLECULE: U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5;                  
COMPND  95 CHAIN: 5;                                                            
COMPND  96 SYNONYM: LSM5;                                                       
COMPND  97 MOL_ID: 25;                                                          
COMPND  98 MOLECULE: U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6;                  
COMPND  99 CHAIN: 6;                                                            
COMPND 100 SYNONYM: LSM6;                                                       
COMPND 101 MOL_ID: 26;                                                          
COMPND 102 MOLECULE: U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7;                  
COMPND 103 CHAIN: 7;                                                            
COMPND 104 SYNONYM: LSM7;                                                       
COMPND 105 MOL_ID: 27;                                                          
COMPND 106 MOLECULE: U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8;                  
COMPND 107 CHAIN: 8;                                                            
COMPND 108 SYNONYM: LSM8;                                                       
COMPND 109 MOL_ID: 28;                                                          
COMPND 110 MOLECULE: PRE-MRNA-SPLICING FACTOR SNU114;                           
COMPND 111 CHAIN: C;                                                            
COMPND 112 SYNONYM: 114 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT,GROWTH 
COMPND 113 INHIBITORY PROTEIN 10, SNU114                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   3 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   4 ORGANISM_TAXID: 4932;                                                
SOURCE   5 STRAIN: BCY123;                                                      
SOURCE   6 MOL_ID: 2;                                                           
SOURCE   7 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   8 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   9 ORGANISM_TAXID: 4932;                                                
SOURCE  10 STRAIN: BCY123;                                                      
SOURCE  11 MOL_ID: 3;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  13 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  14 ORGANISM_TAXID: 4932;                                                
SOURCE  15 STRAIN: BCY123;                                                      
SOURCE  16 MOL_ID: 4;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  18 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  19 ORGANISM_TAXID: 4932;                                                
SOURCE  20 STRAIN: BCY123;                                                      
SOURCE  21 MOL_ID: 5;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  23 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  24 ORGANISM_TAXID: 4932;                                                
SOURCE  25 STRAIN: BCY123;                                                      
SOURCE  26 MOL_ID: 6;                                                           
SOURCE  27 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  28 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  29 ORGANISM_TAXID: 4932;                                                
SOURCE  30 STRAIN: BCY123;                                                      
SOURCE  31 MOL_ID: 7;                                                           
SOURCE  32 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  33 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  34 ORGANISM_TAXID: 4932;                                                
SOURCE  35 STRAIN: BCY123;                                                      
SOURCE  36 MOL_ID: 8;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  38 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  39 ORGANISM_TAXID: 4932;                                                
SOURCE  40 STRAIN: BCY123;                                                      
SOURCE  41 MOL_ID: 9;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  43 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  44 ORGANISM_TAXID: 4932;                                                
SOURCE  45 STRAIN: BCY123;                                                      
SOURCE  46 MOL_ID: 10;                                                          
SOURCE  47 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  48 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  49 ORGANISM_TAXID: 4932;                                                
SOURCE  50 STRAIN: BCY123;                                                      
SOURCE  51 MOL_ID: 11;                                                          
SOURCE  52 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  53 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  54 ORGANISM_TAXID: 4932;                                                
SOURCE  55 STRAIN: BCY123;                                                      
SOURCE  56 MOL_ID: 12;                                                          
SOURCE  57 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  58 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  59 ORGANISM_TAXID: 4932;                                                
SOURCE  60 STRAIN: BCY123;                                                      
SOURCE  61 MOL_ID: 13;                                                          
SOURCE  62 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  63 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  64 ORGANISM_TAXID: 4932;                                                
SOURCE  65 STRAIN: BCY123;                                                      
SOURCE  66 MOL_ID: 14;                                                          
SOURCE  67 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  68 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  69 ORGANISM_TAXID: 4932;                                                
SOURCE  70 STRAIN: BCY123;                                                      
SOURCE  71 MOL_ID: 15;                                                          
SOURCE  72 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  73 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  74 ORGANISM_TAXID: 4932;                                                
SOURCE  75 STRAIN: BCY123;                                                      
SOURCE  76 MOL_ID: 16;                                                          
SOURCE  77 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  78 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  79 ORGANISM_TAXID: 4932;                                                
SOURCE  80 STRAIN: BCY123;                                                      
SOURCE  81 MOL_ID: 17;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  83 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  84 ORGANISM_TAXID: 4932;                                                
SOURCE  85 STRAIN: BCY123;                                                      
SOURCE  86 MOL_ID: 18;                                                          
SOURCE  87 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  88 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  89 ORGANISM_TAXID: 4932;                                                
SOURCE  90 STRAIN: BCY123;                                                      
SOURCE  91 MOL_ID: 19;                                                          
SOURCE  92 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  93 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  94 ORGANISM_TAXID: 4932;                                                
SOURCE  95 STRAIN: BCY123;                                                      
SOURCE  96 MOL_ID: 20;                                                          
SOURCE  97 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  98 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  99 ORGANISM_TAXID: 4932;                                                
SOURCE 100 STRAIN: BCY123;                                                      
SOURCE 101 MOL_ID: 21;                                                          
SOURCE 102 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 103 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 104 ORGANISM_TAXID: 4932;                                                
SOURCE 105 STRAIN: BCY123;                                                      
SOURCE 106 MOL_ID: 22;                                                          
SOURCE 107 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 108 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 109 ORGANISM_TAXID: 4932;                                                
SOURCE 110 STRAIN: BCY123;                                                      
SOURCE 111 MOL_ID: 23;                                                          
SOURCE 112 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 113 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 114 ORGANISM_TAXID: 4932;                                                
SOURCE 115 STRAIN: BCY123;                                                      
SOURCE 116 MOL_ID: 24;                                                          
SOURCE 117 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 118 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 119 ORGANISM_TAXID: 4932;                                                
SOURCE 120 STRAIN: BCY123;                                                      
SOURCE 121 MOL_ID: 25;                                                          
SOURCE 122 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 123 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 124 ORGANISM_TAXID: 4932;                                                
SOURCE 125 STRAIN: BCY123;                                                      
SOURCE 126 MOL_ID: 26;                                                          
SOURCE 127 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 128 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 129 ORGANISM_TAXID: 4932;                                                
SOURCE 130 STRAIN: BCY123;                                                      
SOURCE 131 MOL_ID: 27;                                                          
SOURCE 132 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 133 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 134 ORGANISM_TAXID: 4932;                                                
SOURCE 135 STRAIN: BCY123;                                                      
SOURCE 136 MOL_ID: 28;                                                          
SOURCE 137 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 138 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 139 ORGANISM_TAXID: 4932;                                                
SOURCE 140 STRAIN: BCY123                                                       
KEYWDS    PRE-MRNA SPLICING, SNRNP, GTPASE, U5 SNRNA, PRP8, SPLICEOSOME, U4/U6  
KEYWDS   2 SNRNP, BRR2, SNU114, TRANSCRIPTION                                   
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    T.H.D.NGUYEN,W.P.GALEJ,X.C.BAI,C.OUBRIDGE,S.H.W.SCHERES,A.J.NEWMAN,   
AUTHOR   2 K.NAGAI                                                              
REVDAT   7   20-FEB-19 5GAN    1       REMARK LINK                              
REVDAT   6   21-MAR-18 5GAN    1       COMPND CRYST1                            
REVDAT   5   30-AUG-17 5GAN    1       REMARK LINK                              
REVDAT   4   25-MAY-16 5GAN    1                                                
REVDAT   3   09-MAR-16 5GAN    1       JRNL                                     
REVDAT   2   02-MAR-16 5GAN    1       JRNL                                     
REVDAT   1   27-JAN-16 5GAN    0                                                
JRNL        AUTH   T.H.NGUYEN,W.P.GALEJ,X.C.BAI,C.OUBRIDGE,A.J.NEWMAN,          
JRNL        AUTH 2 S.H.SCHERES,K.NAGAI                                          
JRNL        TITL   CRYO-EM STRUCTURE OF THE YEAST U4/U6.U5 TRI-SNRNP AT 3.7     
JRNL        TITL 2 ANGSTROM RESOLUTION.                                         
JRNL        REF    NATURE                        V. 530   298 2016              
JRNL        REFN                   ESSN 1476-4687                               
JRNL        PMID   26829225                                                     
JRNL        DOI    10.1038/NATURE16940                                          
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   T.H.D.NGUYEN,W.GALEJ,X.C.BAI,C.G.SAVVA,A.J.NEWMAN,           
REMARK   1  AUTH 2 S.H.W.SCHERES,K.NAGAI                                        
REMARK   1  TITL   THE ARCHITECTURE OF THE SPLICEOSOMAL U4/U6.U5 TRI-SNRNP.     
REMARK   1  REF    NATURE                        V. 523    47 2015              
REMARK   1  REFN                   ESSN 1476-4687                               
REMARK   1  PMID   26106855                                                     
REMARK   1  DOI    10.1038/NATURE14548                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION, CTFFIND, COOT, REFMAC, RELION,    
REMARK   3                            RELION, RELION, RELION                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : RECIPROCAL                          
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.700                          
REMARK   3   NUMBER OF PARTICLES               : 140155                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING ONLY            
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5GAN COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 08-JAN-16.                  
REMARK 100 THE DEPOSITION ID IS D_1001300041.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : THE OVERALL STRUCTURE OF THE      
REMARK 245                                    YEAST SPLICEOSOMAL U4/U6.U5 TRI-  
REMARK 245                                    SNRNP                             
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.20                              
REMARK 245   SAMPLE SUPPORT DETAILS         : GRIDS ARE MADE OF HOLEY CARBON,   
REMARK 245                                    CARBON-COATED AND GLOW            
REMARK 245                                    DISCHARGED IN N-AMYLAMINE.        
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.90                              
REMARK 245   SAMPLE DETAILS                 : 30 PROTEINS AND 3 SNRNAS          
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 2477                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : 500.00                         
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3500.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.00                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 38.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 81000                          
REMARK 245   CALIBRATED MAGNIFICATION          : 35714                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 35-MERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 35-MERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 152010 ANGSTROM**2                        
REMARK 350 SURFACE AREA OF THE COMPLEX: 420400 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -952.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: V, W, A, H, J, D, F, G, B, x,         
REMARK 350                    AND CHAINS: k, l, m, n, p, q, r, E, b,            
REMARK 350                    AND CHAINS: e, f, g, d, h, j, U, K, 2, 3,         
REMARK 350                    AND CHAINS: 4, 5, 6, 7, 8, C                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465       A V    68                                                      
REMARK 465       U V    69                                                      
REMARK 465       U V    70                                                      
REMARK 465       U V    71                                                      
REMARK 465       A V    72                                                      
REMARK 465       U V   105                                                      
REMARK 465       C V   106                                                      
REMARK 465       G V   107                                                      
REMARK 465       G V   108                                                      
REMARK 465       U V   109                                                      
REMARK 465       G V   110                                                      
REMARK 465       U V   111                                                      
REMARK 465       U V   112                                                      
REMARK 465       C V   113                                                      
REMARK 465       G V   114                                                      
REMARK 465       C V   115                                                      
REMARK 465       U V   116                                                      
REMARK 465       U V   117                                                      
REMARK 465       U V   118                                                      
REMARK 465       U V   119                                                      
REMARK 465       G V   120                                                      
REMARK 465       A V   121                                                      
REMARK 465       A V   122                                                      
REMARK 465       U V   123                                                      
REMARK 465       A V   124                                                      
REMARK 465       C V   125                                                      
REMARK 465       U V   126                                                      
REMARK 465       U V   127                                                      
REMARK 465       A V   153                                                      
REMARK 465       U V   154                                                      
REMARK 465       A V   155                                                      
REMARK 465       C V   156                                                      
REMARK 465       C V   157                                                      
REMARK 465       U V   158                                                      
REMARK 465       U V   159                                                      
REMARK 465       U V   160                                                      
REMARK 465       G W    10                                                      
REMARK 465       U W    11                                                      
REMARK 465       A W    12                                                      
REMARK 465       A W    13                                                      
REMARK 465       C W    14                                                      
REMARK 465       C W    15                                                      
REMARK 465       A W    40                                                      
REMARK 465       A W    41                                                      
REMARK 465       A W    42                                                      
REMARK 465       C W    43                                                      
REMARK 465       G W    52                                                      
REMARK 465       A W    53                                                      
REMARK 465       U W    54                                                      
REMARK 465       U W    89                                                      
REMARK 465       U W    90                                                      
REMARK 465       A W    91                                                      
REMARK 465       C W    92                                                      
REMARK 465       A W    93                                                      
REMARK 465       A W    94                                                      
REMARK 465       A W    95                                                      
REMARK 465       G W    96                                                      
REMARK 465       A W    97                                                      
REMARK 465       G W    98                                                      
REMARK 465       A W    99                                                      
REMARK 465       U W   100                                                      
REMARK 465       U W   101                                                      
REMARK 465       U W   102                                                      
REMARK 465       A W   103                                                      
REMARK 465       U W   104                                                      
REMARK 465       U W   105                                                      
REMARK 465       U W   106                                                      
REMARK 465       C W   107                                                      
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     GLY A     3                                                      
REMARK 465     LEU A     4                                                      
REMARK 465     PRO A     5                                                      
REMARK 465     PRO A     6                                                      
REMARK 465     PRO A     7                                                      
REMARK 465     PRO A     8                                                      
REMARK 465     PRO A     9                                                      
REMARK 465     GLY A    10                                                      
REMARK 465     PHE A    11                                                      
REMARK 465     GLU A    12                                                      
REMARK 465     GLU A    13                                                      
REMARK 465     ASP A    14                                                      
REMARK 465     SER A    15                                                      
REMARK 465     ASP A    16                                                      
REMARK 465     LEU A    17                                                      
REMARK 465     ALA A    18                                                      
REMARK 465     LEU A    19                                                      
REMARK 465     PRO A    20                                                      
REMARK 465     PRO A    21                                                      
REMARK 465     PRO A    22                                                      
REMARK 465     PRO A    23                                                      
REMARK 465     PRO A    24                                                      
REMARK 465     PRO A    25                                                      
REMARK 465     PRO A    26                                                      
REMARK 465     PRO A    27                                                      
REMARK 465     GLY A    28                                                      
REMARK 465     TYR A    29                                                      
REMARK 465     GLU A    30                                                      
REMARK 465     ILE A    31                                                      
REMARK 465     GLU A    32                                                      
REMARK 465     GLU A    33                                                      
REMARK 465     LEU A    34                                                      
REMARK 465     ASP A    35                                                      
REMARK 465     ASN A    36                                                      
REMARK 465     PRO A    37                                                      
REMARK 465     MET A    38                                                      
REMARK 465     VAL A    39                                                      
REMARK 465     PRO A    40                                                      
REMARK 465     SER A    41                                                      
REMARK 465     SER A    42                                                      
REMARK 465     VAL A    43                                                      
REMARK 465     ASN A    44                                                      
REMARK 465     GLU A    45                                                      
REMARK 465     ASP A    46                                                      
REMARK 465     THR A    47                                                      
REMARK 465     PHE A    48                                                      
REMARK 465     LEU A    49                                                      
REMARK 465     PRO A    50                                                      
REMARK 465     PRO A    51                                                      
REMARK 465     PRO A    52                                                      
REMARK 465     PRO A    53                                                      
REMARK 465     PRO A    54                                                      
REMARK 465     PRO A    55                                                      
REMARK 465     PRO A    56                                                      
REMARK 465     SER A    57                                                      
REMARK 465     ASN A    58                                                      
REMARK 465     PHE A    59                                                      
REMARK 465     GLU A    60                                                      
REMARK 465     ILE A    61                                                      
REMARK 465     ASN A    62                                                      
REMARK 465     ALA A    63                                                      
REMARK 465     GLU A    64                                                      
REMARK 465     GLU A    65                                                      
REMARK 465     ILE A    66                                                      
REMARK 465     VAL A    67                                                      
REMARK 465     ASP A    68                                                      
REMARK 465     PHE A    69                                                      
REMARK 465     THR A    70                                                      
REMARK 465     LEU A    71                                                      
REMARK 465     PRO A    72                                                      
REMARK 465     PRO A    73                                                      
REMARK 465     PRO A    74                                                      
REMARK 465     PRO A    75                                                      
REMARK 465     PRO A    76                                                      
REMARK 465     PRO A    77                                                      
REMARK 465     PRO A    78                                                      
REMARK 465     GLY A    79                                                      
REMARK 465     LEU A    80                                                      
REMARK 465     ASP A    81                                                      
REMARK 465     GLU A    82                                                      
REMARK 465     LEU A    83                                                      
REMARK 465     GLU A    84                                                      
REMARK 465     THR A    85                                                      
REMARK 465     LYS A    86                                                      
REMARK 465     ALA A    87                                                      
REMARK 465     GLU A    88                                                      
REMARK 465     LYS A    89                                                      
REMARK 465     LYS A    90                                                      
REMARK 465     VAL A    91                                                      
REMARK 465     GLU A    92                                                      
REMARK 465     LEU A    93                                                      
REMARK 465     HIS A    94                                                      
REMARK 465     GLY A    95                                                      
REMARK 465     LYS A    96                                                      
REMARK 465     ARG A    97                                                      
REMARK 465     LYS A    98                                                      
REMARK 465     LEU A    99                                                      
REMARK 465     ASP A   100                                                      
REMARK 465     ILE A   101                                                      
REMARK 465     GLY A   102                                                      
REMARK 465     LYS A   103                                                      
REMARK 465     ASP A   104                                                      
REMARK 465     THR A   105                                                      
REMARK 465     PHE A   106                                                      
REMARK 465     VAL A   107                                                      
REMARK 465     THR A   108                                                      
REMARK 465     ARG A   109                                                      
REMARK 465     SER A   151                                                      
REMARK 465     LYS A   152                                                      
REMARK 465     MET A   153                                                      
REMARK 465     TYR A   154                                                      
REMARK 465     ASN A   429                                                      
REMARK 465     PRO A   430                                                      
REMARK 465     ILE A   431                                                      
REMARK 465     PRO A   432                                                      
REMARK 465     HIS A   433                                                      
REMARK 465     PHE A   434                                                      
REMARK 465     ILE A   435                                                      
REMARK 465     ASP A   436                                                      
REMARK 465     ASN A   437                                                      
REMARK 465     ASN A   438                                                      
REMARK 465     SER A   439                                                      
REMARK 465     SER A   440                                                      
REMARK 465     LEU A   441                                                      
REMARK 465     ASN A   442                                                      
REMARK 465     VAL A   443                                                      
REMARK 465     SER A   444                                                      
REMARK 465     ASN A   445                                                      
REMARK 465     THR A   446                                                      
REMARK 465     LYS A   447                                                      
REMARK 465     GLU A   448                                                      
REMARK 465     ASN A   449                                                      
REMARK 465     GLY A   450                                                      
REMARK 465     ASP A   451                                                      
REMARK 465     PHE A   452                                                      
REMARK 465     THR A   453                                                      
REMARK 465     LEU A   454                                                      
REMARK 465     PRO A   455                                                      
REMARK 465     GLU A   456                                                      
REMARK 465     ASP A   457                                                      
REMARK 465     PHE A   458                                                      
REMARK 465     GLY A   736                                                      
REMARK 465     ARG A   737                                                      
REMARK 465     SER A   738                                                      
REMARK 465     ASN A   739                                                      
REMARK 465     GLU A   740                                                      
REMARK 465     ILE A   741                                                      
REMARK 465     VAL A   742                                                      
REMARK 465     LYS A   743                                                      
REMARK 465     THR A   744                                                      
REMARK 465     THR A   745                                                      
REMARK 465     THR A   746                                                      
REMARK 465     LYS A   747                                                      
REMARK 465     GLN A   748                                                      
REMARK 465     ARG A   749                                                      
REMARK 465     LEU A   750                                                      
REMARK 465     GLY A  1428                                                      
REMARK 465     MET A  1429                                                      
REMARK 465     THR A  1430                                                      
REMARK 465     HIS A  1431                                                      
REMARK 465     GLU A  1432                                                      
REMARK 465     ARG A  2105                                                      
REMARK 465     SER A  2106                                                      
REMARK 465     GLU A  2107                                                      
REMARK 465     LYS A  2108                                                      
REMARK 465     GLN A  2109                                                      
REMARK 465     ASN A  2110                                                      
REMARK 465     ASP A  2111                                                      
REMARK 465     GLU A  2112                                                      
REMARK 465     GLU A  2113                                                      
REMARK 465     ALA A  2114                                                      
REMARK 465     ALA A  2115                                                      
REMARK 465     GLY A  2116                                                      
REMARK 465     ALA A  2117                                                      
REMARK 465     SER A  2118                                                      
REMARK 465     THR A  2119                                                      
REMARK 465     VAL A  2120                                                      
REMARK 465     MET A  2121                                                      
REMARK 465     LYS A  2122                                                      
REMARK 465     THR A  2123                                                      
REMARK 465     LYS A  2124                                                      
REMARK 465     THR A  2125                                                      
REMARK 465     ILE A  2126                                                      
REMARK 465     ASN A  2127                                                      
REMARK 465     ALA A  2128                                                      
REMARK 465     GLN A  2129                                                      
REMARK 465     GLY A  2130                                                      
REMARK 465     GLU A  2131                                                      
REMARK 465     GLU A  2132                                                      
REMARK 465     ILE A  2133                                                      
REMARK 465     VAL A  2134                                                      
REMARK 465     VAL A  2135                                                      
REMARK 465     VAL A  2136                                                      
REMARK 465     ALA A  2137                                                      
REMARK 465     SER A  2138                                                      
REMARK 465     ALA A  2139                                                      
REMARK 465     ASP A  2140                                                      
REMARK 465     TYR A  2141                                                      
REMARK 465     GLU A  2142                                                      
REMARK 465     SER A  2143                                                      
REMARK 465     GLN A  2144                                                      
REMARK 465     THR A  2145                                                      
REMARK 465     PHE A  2146                                                      
REMARK 465     GLU A  2402                                                      
REMARK 465     GLU A  2403                                                      
REMARK 465     LEU A  2404                                                      
REMARK 465     GLU A  2405                                                      
REMARK 465     ALA A  2406                                                      
REMARK 465     GLU A  2407                                                      
REMARK 465     GLN A  2408                                                      
REMARK 465     ILE A  2409                                                      
REMARK 465     ASP A  2410                                                      
REMARK 465     VAL A  2411                                                      
REMARK 465     PHE A  2412                                                      
REMARK 465     SER A  2413                                                      
REMARK 465     MET H     1                                                      
REMARK 465     SER H     2                                                      
REMARK 465     LYS H     3                                                      
REMARK 465     TYR H     4                                                      
REMARK 465     ILE H     5                                                      
REMARK 465     ALA H     6                                                      
REMARK 465     LEU H     7                                                      
REMARK 465     GLU H     8                                                      
REMARK 465     ASN H     9                                                      
REMARK 465     LEU H    10                                                      
REMARK 465     PRO H    11                                                      
REMARK 465     VAL H    12                                                      
REMARK 465     ASP H    13                                                      
REMARK 465     LEU H    14                                                      
REMARK 465     GLN H    15                                                      
REMARK 465     HIS H    16                                                      
REMARK 465     LYS H    17                                                      
REMARK 465     GLY H    18                                                      
REMARK 465     ALA H    19                                                      
REMARK 465     THR H    20                                                      
REMARK 465     GLN H    21                                                      
REMARK 465     ASN H    22                                                      
REMARK 465     GLU H    23                                                      
REMARK 465     SER H    24                                                      
REMARK 465     THR H    25                                                      
REMARK 465     ALA H    26                                                      
REMARK 465     ASP H    27                                                      
REMARK 465     ILE H    28                                                      
REMARK 465     LEU H    29                                                      
REMARK 465     LYS H    30                                                      
REMARK 465     GLN H    31                                                      
REMARK 465     LEU H    32                                                      
REMARK 465     PRO H    33                                                      
REMARK 465     HIS H    34                                                      
REMARK 465     GLU H    35                                                      
REMARK 465     ARG H    36                                                      
REMARK 465     LEU H    37                                                      
REMARK 465     GLN H    38                                                      
REMARK 465     ALA H    39                                                      
REMARK 465     VAL H    40                                                      
REMARK 465     LEU H    41                                                      
REMARK 465     GLU H    42                                                      
REMARK 465     LYS H    43                                                      
REMARK 465     ILE H    44                                                      
REMARK 465     PRO H    45                                                      
REMARK 465     GLU H    46                                                      
REMARK 465     GLU H    47                                                      
REMARK 465     ASP H    48                                                      
REMARK 465     LEU H    49                                                      
REMARK 465     GLU H    50                                                      
REMARK 465     VAL H    51                                                      
REMARK 465     ARG H    52                                                      
REMARK 465     ARG H    53                                                      
REMARK 465     LEU H    54                                                      
REMARK 465     LEU H    55                                                      
REMARK 465     SER H    56                                                      
REMARK 465     ILE H    57                                                      
REMARK 465     LEU H    58                                                      
REMARK 465     LYS H    59                                                      
REMARK 465     LYS H    60                                                      
REMARK 465     PRO H    61                                                      
REMARK 465     GLU H    62                                                      
REMARK 465     VAL H    63                                                      
REMARK 465     VAL H    64                                                      
REMARK 465     GLU H    65                                                      
REMARK 465     ASN H    66                                                      
REMARK 465     GLU H    67                                                      
REMARK 465     ASP H    68                                                      
REMARK 465     VAL H    69                                                      
REMARK 465     GLN H    70                                                      
REMARK 465     GLN H    71                                                      
REMARK 465     ARG H    72                                                      
REMARK 465     ARG H    73                                                      
REMARK 465     ILE H    74                                                      
REMARK 465     ARG H    75                                                      
REMARK 465     LEU H    76                                                      
REMARK 465     ALA H    77                                                      
REMARK 465     GLU H    78                                                      
REMARK 465     ILE H    79                                                      
REMARK 465     LEU H    80                                                      
REMARK 465     MET H    81                                                      
REMARK 465     VAL H    82                                                      
REMARK 465     ASP H    83                                                      
REMARK 465     GLU H    84                                                      
REMARK 465     ILE H    85                                                      
REMARK 465     ASP H    86                                                      
REMARK 465     LEU H    87                                                      
REMARK 465     GLU H    88                                                      
REMARK 465     ASN H    89                                                      
REMARK 465     ILE H    90                                                      
REMARK 465     ASN H    91                                                      
REMARK 465     ASN H    92                                                      
REMARK 465     MET H    93                                                      
REMARK 465     GLU H    94                                                      
REMARK 465     ASN H    95                                                      
REMARK 465     ILE H    96                                                      
REMARK 465     ASN H    97                                                      
REMARK 465     GLY H    98                                                      
REMARK 465     GLU H    99                                                      
REMARK 465     GLU H   100                                                      
REMARK 465     VAL H   101                                                      
REMARK 465     ASP H   102                                                      
REMARK 465     GLU H   103                                                      
REMARK 465     GLU H   104                                                      
REMARK 465     ASP H   105                                                      
REMARK 465     ASP H   106                                                      
REMARK 465     GLU H   107                                                      
REMARK 465     ASP H   108                                                      
REMARK 465     MET J     1                                                      
REMARK 465     GLU J     2                                                      
REMARK 465     ARG J     3                                                      
REMARK 465     PRO J     4                                                      
REMARK 465     SER J     5                                                      
REMARK 465     PHE J     6                                                      
REMARK 465     LEU J     7                                                      
REMARK 465     ASP J     8                                                      
REMARK 465     GLN J     9                                                      
REMARK 465     GLU J    10                                                      
REMARK 465     PRO J    11                                                      
REMARK 465     PRO J    12                                                      
REMARK 465     ALA J    13                                                      
REMARK 465     GLY J    14                                                      
REMARK 465     TYR J    15                                                      
REMARK 465     VAL J    16                                                      
REMARK 465     PRO J    17                                                      
REMARK 465     GLY J    18                                                      
REMARK 465     ILE J    19                                                      
REMARK 465     GLY J    20                                                      
REMARK 465     ARG J    21                                                      
REMARK 465     GLY J    22                                                      
REMARK 465     ALA J    23                                                      
REMARK 465     THR J    24                                                      
REMARK 465     GLY J    25                                                      
REMARK 465     PHE J    26                                                      
REMARK 465     SER J    27                                                      
REMARK 465     THR J    28                                                      
REMARK 465     LYS J    29                                                      
REMARK 465     GLU J    30                                                      
REMARK 465     LYS J    31                                                      
REMARK 465     GLN J    32                                                      
REMARK 465     VAL J    33                                                      
REMARK 465     VAL J    34                                                      
REMARK 465     SER J    35                                                      
REMARK 465     ASN J    36                                                      
REMARK 465     ASP J    37                                                      
REMARK 465     ASP J    38                                                      
REMARK 465     LYS J    39                                                      
REMARK 465     GLY J    40                                                      
REMARK 465     ARG J    41                                                      
REMARK 465     ARG J    42                                                      
REMARK 465     ILE J    43                                                      
REMARK 465     PRO J    44                                                      
REMARK 465     LYS J    45                                                      
REMARK 465     ARG J    46                                                      
REMARK 465     TYR J    47                                                      
REMARK 465     ARG J    48                                                      
REMARK 465     GLU J    49                                                      
REMARK 465     ASN J    50                                                      
REMARK 465     LEU J    51                                                      
REMARK 465     ASN J    52                                                      
REMARK 465     ASN J    53                                                      
REMARK 465     HIS J    54                                                      
REMARK 465     LEU J    55                                                      
REMARK 465     GLN J    56                                                      
REMARK 465     SER J    57                                                      
REMARK 465     GLN J    58                                                      
REMARK 465     PRO J    59                                                      
REMARK 465     LYS J    60                                                      
REMARK 465     ASP J    61                                                      
REMARK 465     ASP J    62                                                      
REMARK 465     GLU J    63                                                      
REMARK 465     ASP J    64                                                      
REMARK 465     ASP J    65                                                      
REMARK 465     GLU J    66                                                      
REMARK 465     ALA J    67                                                      
REMARK 465     ALA J    68                                                      
REMARK 465     ASN J    69                                                      
REMARK 465     VAL J    70                                                      
REMARK 465     PHE J    71                                                      
REMARK 465     LYS J    72                                                      
REMARK 465     THR J    73                                                      
REMARK 465     LEU J    74                                                      
REMARK 465     GLU J    75                                                      
REMARK 465     LEU J    76                                                      
REMARK 465     LYS J    77                                                      
REMARK 465     LEU J    78                                                      
REMARK 465     ALA J    79                                                      
REMARK 465     GLN J    80                                                      
REMARK 465     LYS J    81                                                      
REMARK 465     LYS J    82                                                      
REMARK 465     LYS J    83                                                      
REMARK 465     LYS J    84                                                      
REMARK 465     ARG J    85                                                      
REMARK 465     ALA J    86                                                      
REMARK 465     ASN J    87                                                      
REMARK 465     GLU J    88                                                      
REMARK 465     LYS J    89                                                      
REMARK 465     ASP J    90                                                      
REMARK 465     ASP J    91                                                      
REMARK 465     ASP J    92                                                      
REMARK 465     ASN J    93                                                      
REMARK 465     SER J    94                                                      
REMARK 465     VAL J    95                                                      
REMARK 465     ASP J    96                                                      
REMARK 465     SER J    97                                                      
REMARK 465     SER J    98                                                      
REMARK 465     ASN J    99                                                      
REMARK 465     VAL J   100                                                      
REMARK 465     LYS J   101                                                      
REMARK 465     ARG J   102                                                      
REMARK 465     GLN J   103                                                      
REMARK 465     PHE J   104                                                      
REMARK 465     ALA J   105                                                      
REMARK 465     ASP J   106                                                      
REMARK 465     LEU J   107                                                      
REMARK 465     LYS J   108                                                      
REMARK 465     GLU J   109                                                      
REMARK 465     SER J   110                                                      
REMARK 465     LEU J   111                                                      
REMARK 465     ALA J   112                                                      
REMARK 465     ALA J   113                                                      
REMARK 465     VAL J   114                                                      
REMARK 465     THR J   115                                                      
REMARK 465     GLU J   116                                                      
REMARK 465     SER J   117                                                      
REMARK 465     GLU J   118                                                      
REMARK 465     TRP J   119                                                      
REMARK 465     MET J   120                                                      
REMARK 465     ASP J   121                                                      
REMARK 465     ILE J   122                                                      
REMARK 465     PRO J   123                                                      
REMARK 465     ASP J   124                                                      
REMARK 465     ALA J   125                                                      
REMARK 465     THR J   126                                                      
REMARK 465     ASP J   127                                                      
REMARK 465     PHE J   128                                                      
REMARK 465     THR J   129                                                      
REMARK 465     ARG J   130                                                      
REMARK 465     ARG J   131                                                      
REMARK 465     ASN J   132                                                      
REMARK 465     LYS J   133                                                      
REMARK 465     ARG J   134                                                      
REMARK 465     ASN J   135                                                      
REMARK 465     ARG J   136                                                      
REMARK 465     ILE J   137                                                      
REMARK 465     GLN J   138                                                      
REMARK 465     GLU J   139                                                      
REMARK 465     GLN J   140                                                      
REMARK 465     LEU J   141                                                      
REMARK 465     ASN J   142                                                      
REMARK 465     ARG J   143                                                      
REMARK 465     LYS J   144                                                      
REMARK 465     THR J   145                                                      
REMARK 465     TYR J   146                                                      
REMARK 465     ALA J   147                                                      
REMARK 465     ALA J   148                                                      
REMARK 465     PRO J   149                                                      
REMARK 465     ASP J   150                                                      
REMARK 465     SER J   151                                                      
REMARK 465     LEU J   152                                                      
REMARK 465     ILE J   153                                                      
REMARK 465     PRO J   154                                                      
REMARK 465     ASP J   415                                                      
REMARK 465     ILE J   416                                                      
REMARK 465     PRO J   417                                                      
REMARK 465     VAL J   418                                                      
REMARK 465     ASP J   419                                                      
REMARK 465     HIS J   527                                                      
REMARK 465     LYS J   528                                                      
REMARK 465     ILE J   529                                                      
REMARK 465     LYS J   544                                                      
REMARK 465     ASN J   545                                                      
REMARK 465     VAL J   881                                                      
REMARK 465     LYS J   882                                                      
REMARK 465     MET J   883                                                      
REMARK 465     GLN J   884                                                      
REMARK 465     TYR J   885                                                      
REMARK 465     LYS J   899                                                      
REMARK 465     MET D     1                                                      
REMARK 465     VAL D   142                                                      
REMARK 465     SER D   143                                                      
REMARK 465     MET F     1                                                      
REMARK 465     SER F     2                                                      
REMARK 465     SER F     3                                                      
REMARK 465     GLU F     4                                                      
REMARK 465     GLU F     5                                                      
REMARK 465     ASP F     6                                                      
REMARK 465     TYR F     7                                                      
REMARK 465     PHE F     8                                                      
REMARK 465     ASP F     9                                                      
REMARK 465     GLU F    10                                                      
REMARK 465     LEU F    11                                                      
REMARK 465     GLU F    12                                                      
REMARK 465     TYR F    13                                                      
REMARK 465     ASP F    14                                                      
REMARK 465     LEU F    15                                                      
REMARK 465     ALA F    16                                                      
REMARK 465     ASP F    17                                                      
REMARK 465     GLU F    18                                                      
REMARK 465     VAL F    19                                                      
REMARK 465     ASN F    20                                                      
REMARK 465     GLU F    21                                                      
REMARK 465     GLU F    22                                                      
REMARK 465     LYS F    23                                                      
REMARK 465     GLU F    24                                                      
REMARK 465     ASP F    25                                                      
REMARK 465     ILE F    26                                                      
REMARK 465     GLN F    27                                                      
REMARK 465     THR F    28                                                      
REMARK 465     LYS F    29                                                      
REMARK 465     LYS F    30                                                      
REMARK 465     LEU F    31                                                      
REMARK 465     THR F    32                                                      
REMARK 465     THR F    33                                                      
REMARK 465     VAL F    34                                                      
REMARK 465     ASN F    35                                                      
REMARK 465     CYS F    36                                                      
REMARK 465     GLN F    37                                                      
REMARK 465     THR F    38                                                      
REMARK 465     GLU F    39                                                      
REMARK 465     LYS F    40                                                      
REMARK 465     PHE F    41                                                      
REMARK 465     ASN F    42                                                      
REMARK 465     SER F   458                                                      
REMARK 465     LEU F   459                                                      
REMARK 465     GLY F   460                                                      
REMARK 465     HIS F   461                                                      
REMARK 465     ASN F   462                                                      
REMARK 465     THR F   463                                                      
REMARK 465     GLU F   464                                                      
REMARK 465     GLN F   465                                                      
REMARK 465     PRO F   466                                                      
REMARK 465     ASN F   467                                                      
REMARK 465     LEU F   468                                                      
REMARK 465     SER F   469                                                      
REMARK 465     PRO F   470                                                      
REMARK 465     GLU F   471                                                      
REMARK 465     MET F   472                                                      
REMARK 465     VAL F   473                                                      
REMARK 465     GLN F   474                                                      
REMARK 465     MET F   475                                                      
REMARK 465     HIS F   476                                                      
REMARK 465     LYS F   477                                                      
REMARK 465     LYS F   478                                                      
REMARK 465     GLN F   479                                                      
REMARK 465     HIS F   480                                                      
REMARK 465     THR F   481                                                      
REMARK 465     ASN F   482                                                      
REMARK 465     PRO F   483                                                      
REMARK 465     GLU F   484                                                      
REMARK 465     GLU F   485                                                      
REMARK 465     GLU F   486                                                      
REMARK 465     THR F   487                                                      
REMARK 465     ASN F   488                                                      
REMARK 465     TRP F   489                                                      
REMARK 465     PHE F   490                                                      
REMARK 465     SER F   491                                                      
REMARK 465     GLY F   492                                                      
REMARK 465     HIS F   493                                                      
REMARK 465     GLY F   494                                                      
REMARK 465     MET G     1                                                      
REMARK 465     PRO G     2                                                      
REMARK 465     PRO G     3                                                      
REMARK 465     ARG G     4                                                      
REMARK 465     ASN G     5                                                      
REMARK 465     THR G     6                                                      
REMARK 465     TYR G     7                                                      
REMARK 465     GLU G     8                                                      
REMARK 465     LYS G     9                                                      
REMARK 465     GLY G    10                                                      
REMARK 465     ASN G    11                                                      
REMARK 465     PRO G    12                                                      
REMARK 465     LYS G    13                                                      
REMARK 465     ARG G    14                                                      
REMARK 465     GLN G    15                                                      
REMARK 465     ASN G    16                                                      
REMARK 465     SER G    17                                                      
REMARK 465     PRO G    18                                                      
REMARK 465     TYR G    19                                                      
REMARK 465     TYR G    20                                                      
REMARK 465     LYS G    21                                                      
REMARK 465     PRO G    22                                                      
REMARK 465     SER G    23                                                      
REMARK 465     PHE G    24                                                      
REMARK 465     LEU G    25                                                      
REMARK 465     ARG G    26                                                      
REMARK 465     ARG G    27                                                      
REMARK 465     GLU G    28                                                      
REMARK 465     GLU G    29                                                      
REMARK 465     THR G    30                                                      
REMARK 465     THR G    31                                                      
REMARK 465     ASN G    32                                                      
REMARK 465     ASP G    33                                                      
REMARK 465     GLU G    34                                                      
REMARK 465     GLU G    35                                                      
REMARK 465     LYS G    36                                                      
REMARK 465     PHE G    37                                                      
REMARK 465     GLN G    38                                                      
REMARK 465     GLY G    39                                                      
REMARK 465     HIS G    40                                                      
REMARK 465     GLY G    41                                                      
REMARK 465     LEU G    42                                                      
REMARK 465     LYS G    43                                                      
REMARK 465     THR G    44                                                      
REMARK 465     GLU G    45                                                      
REMARK 465     LEU G    46                                                      
REMARK 465     HIS G    47                                                      
REMARK 465     SER G    48                                                      
REMARK 465     ALA G    49                                                      
REMARK 465     LEU G    50                                                      
REMARK 465     LYS G    51                                                      
REMARK 465     SER G    52                                                      
REMARK 465     SER G    53                                                      
REMARK 465     ASN G    54                                                      
REMARK 465     LEU G    55                                                      
REMARK 465     ASN G    56                                                      
REMARK 465     LEU G    57                                                      
REMARK 465     ILE G    58                                                      
REMARK 465     ARG G    59                                                      
REMARK 465     ARG G    60                                                      
REMARK 465     THR G    61                                                      
REMARK 465     TYR G    62                                                      
REMARK 465     GLN G    63                                                      
REMARK 465     THR G    64                                                      
REMARK 465     GLY G    65                                                      
REMARK 465     GLU G    66                                                      
REMARK 465     ASN G    67                                                      
REMARK 465     PRO G    68                                                      
REMARK 465     TYR G    69                                                      
REMARK 465     LEU G    70                                                      
REMARK 465     SER G    71                                                      
REMARK 465     ASP G    72                                                      
REMARK 465     PRO G    73                                                      
REMARK 465     HIS G    74                                                      
REMARK 465     ASP G    75                                                      
REMARK 465     ARG G    76                                                      
REMARK 465     GLY G    77                                                      
REMARK 465     SER G    78                                                      
REMARK 465     SER G    79                                                      
REMARK 465     SER G    80                                                      
REMARK 465     ARG G    81                                                      
REMARK 465     PHE G    82                                                      
REMARK 465     ASN G    83                                                      
REMARK 465     ARG G    84                                                      
REMARK 465     ARG G    85                                                      
REMARK 465     TYR G    86                                                      
REMARK 465     GLU G    87                                                      
REMARK 465     ARG G    88                                                      
REMARK 465     GLY G    89                                                      
REMARK 465     LEU G    90                                                      
REMARK 465     LYS G    91                                                      
REMARK 465     PHE G    92                                                      
REMARK 465     TYR G    93                                                      
REMARK 465     GLN G    94                                                      
REMARK 465     LYS G    95                                                      
REMARK 465     GLY G    96                                                      
REMARK 465     GLU G    97                                                      
REMARK 465     ILE G    98                                                      
REMARK 465     SER G    99                                                      
REMARK 465     LYS G   100                                                      
REMARK 465     ARG G   101                                                      
REMARK 465     ILE G   102                                                      
REMARK 465     ALA G   103                                                      
REMARK 465     GLN G   104                                                      
REMARK 465     GLU G   105                                                      
REMARK 465     ARG G   106                                                      
REMARK 465     THR G   107                                                      
REMARK 465     LEU G   108                                                      
REMARK 465     GLN G   109                                                      
REMARK 465     LYS G   110                                                      
REMARK 465     GLN G   111                                                      
REMARK 465     GLN G   112                                                      
REMARK 465     GLU G   113                                                      
REMARK 465     GLU G   114                                                      
REMARK 465     GLU G   115                                                      
REMARK 465     GLU G   116                                                      
REMARK 465     LEU G   117                                                      
REMARK 465     LYS G   118                                                      
REMARK 465     ARG G   119                                                      
REMARK 465     LYS G   120                                                      
REMARK 465     LEU G   121                                                      
REMARK 465     LYS G   122                                                      
REMARK 465     GLN G   123                                                      
REMARK 465     GLU G   124                                                      
REMARK 465     GLU G   125                                                      
REMARK 465     ASP G   126                                                      
REMARK 465     GLU G   127                                                      
REMARK 465     LYS G   128                                                      
REMARK 465     ASP G   129                                                      
REMARK 465     LYS G   130                                                      
REMARK 465     ARG G   131                                                      
REMARK 465     LYS G   132                                                      
REMARK 465     LEU G   133                                                      
REMARK 465     ILE G   134                                                      
REMARK 465     GLU G   135                                                      
REMARK 465     SER G   136                                                      
REMARK 465     GLY G   137                                                      
REMARK 465     ASP G   138                                                      
REMARK 465     LEU G   139                                                      
REMARK 465     PRO G   140                                                      
REMARK 465     ASN G   141                                                      
REMARK 465     LEU G   142                                                      
REMARK 465     GLU G   143                                                      
REMARK 465     LEU G   144                                                      
REMARK 465     HIS G   145                                                      
REMARK 465     GLU G   146                                                      
REMARK 465     ASP G   147                                                      
REMARK 465     LYS G   148                                                      
REMARK 465     PHE G   149                                                      
REMARK 465     GLN G   468                                                      
REMARK 465     THR G   469                                                      
REMARK 465     MET B     1                                                      
REMARK 465     THR B     2                                                      
REMARK 465     GLU B     3                                                      
REMARK 465     HIS B     4                                                      
REMARK 465     GLU B     5                                                      
REMARK 465     THR B     6                                                      
REMARK 465     LYS B     7                                                      
REMARK 465     ASP B     8                                                      
REMARK 465     LYS B     9                                                      
REMARK 465     ALA B    10                                                      
REMARK 465     LYS B    11                                                      
REMARK 465     LYS B    12                                                      
REMARK 465     ILE B    13                                                      
REMARK 465     ARG B    14                                                      
REMARK 465     GLU B    15                                                      
REMARK 465     ILE B    16                                                      
REMARK 465     TYR B    17                                                      
REMARK 465     ARG B    18                                                      
REMARK 465     TYR B    19                                                      
REMARK 465     ASP B    20                                                      
REMARK 465     GLU B    21                                                      
REMARK 465     MET B    22                                                      
REMARK 465     SER B    23                                                      
REMARK 465     ASN B    24                                                      
REMARK 465     LYS B    25                                                      
REMARK 465     VAL B    26                                                      
REMARK 465     LEU B    27                                                      
REMARK 465     LYS B    28                                                      
REMARK 465     VAL B    29                                                      
REMARK 465     ASP B    30                                                      
REMARK 465     LYS B    31                                                      
REMARK 465     ARG B    32                                                      
REMARK 465     PHE B    33                                                      
REMARK 465     MET B    34                                                      
REMARK 465     ASN B    35                                                      
REMARK 465     THR B    36                                                      
REMARK 465     SER B    37                                                      
REMARK 465     GLN B    38                                                      
REMARK 465     ASN B    39                                                      
REMARK 465     PRO B    40                                                      
REMARK 465     GLN B    41                                                      
REMARK 465     ARG B    42                                                      
REMARK 465     ASP B    43                                                      
REMARK 465     ALA B    44                                                      
REMARK 465     GLU B    45                                                      
REMARK 465     ILE B    46                                                      
REMARK 465     SER B    47                                                      
REMARK 465     GLN B    48                                                      
REMARK 465     PRO B    49                                                      
REMARK 465     LYS B    50                                                      
REMARK 465     SER B    51                                                      
REMARK 465     MET B    52                                                      
REMARK 465     SER B    53                                                      
REMARK 465     GLY B    54                                                      
REMARK 465     ARG B    55                                                      
REMARK 465     ILE B    56                                                      
REMARK 465     SER B    57                                                      
REMARK 465     ALA B    58                                                      
REMARK 465     LYS B    59                                                      
REMARK 465     ASP B    60                                                      
REMARK 465     MET B    61                                                      
REMARK 465     GLY B    62                                                      
REMARK 465     GLN B    63                                                      
REMARK 465     GLY B    64                                                      
REMARK 465     LEU B    65                                                      
REMARK 465     CYS B    66                                                      
REMARK 465     ASN B    67                                                      
REMARK 465     ASN B    68                                                      
REMARK 465     ILE B    69                                                      
REMARK 465     ASN B    70                                                      
REMARK 465     LYS B    71                                                      
REMARK 465     GLY B    72                                                      
REMARK 465     LEU B    73                                                      
REMARK 465     LYS B    74                                                      
REMARK 465     GLU B    75                                                      
REMARK 465     ASN B    76                                                      
REMARK 465     ASP B    77                                                      
REMARK 465     VAL B    78                                                      
REMARK 465     ALA B    79                                                      
REMARK 465     VAL B    80                                                      
REMARK 465     GLU B    81                                                      
REMARK 465     LYS B    82                                                      
REMARK 465     THR B    83                                                      
REMARK 465     GLY B    84                                                      
REMARK 465     LYS B    85                                                      
REMARK 465     SER B    86                                                      
REMARK 465     ALA B    87                                                      
REMARK 465     SER B    88                                                      
REMARK 465     LEU B    89                                                      
REMARK 465     LYS B    90                                                      
REMARK 465     LYS B    91                                                      
REMARK 465     ILE B    92                                                      
REMARK 465     GLN B    93                                                      
REMARK 465     GLN B    94                                                      
REMARK 465     HIS B    95                                                      
REMARK 465     ASN B    96                                                      
REMARK 465     THR B    97                                                      
REMARK 465     ILE B    98                                                      
REMARK 465     LEU B    99                                                      
REMARK 465     ASN B   100                                                      
REMARK 465     SER B   101                                                      
REMARK 465     SER B   102                                                      
REMARK 465     SER B   103                                                      
REMARK 465     ASP B   104                                                      
REMARK 465     PHE B   105                                                      
REMARK 465     ARG B   106                                                      
REMARK 465     LEU B   107                                                      
REMARK 465     HIS B   108                                                      
REMARK 465     TYR B   109                                                      
REMARK 465     TYR B   110                                                      
REMARK 465     PRO B   111                                                      
REMARK 465     LYS B   112                                                      
REMARK 465     ASP B   113                                                      
REMARK 465     PRO B   114                                                      
REMARK 465     SER B   115                                                      
REMARK 465     ASN B   116                                                      
REMARK 465     VAL B   117                                                      
REMARK 465     GLU B   118                                                      
REMARK 465     THR B   119                                                      
REMARK 465     TYR B   120                                                      
REMARK 465     GLU B   121                                                      
REMARK 465     GLN B   122                                                      
REMARK 465     ILE B   123                                                      
REMARK 465     LEU B   124                                                      
REMARK 465     GLN B   125                                                      
REMARK 465     TRP B   126                                                      
REMARK 465     VAL B   127                                                      
REMARK 465     THR B   128                                                      
REMARK 465     GLU B   129                                                      
REMARK 465     VAL B   130                                                      
REMARK 465     LEU B   131                                                      
REMARK 465     GLY B   132                                                      
REMARK 465     ASN B   133                                                      
REMARK 465     ASP B   134                                                      
REMARK 465     ILE B   135                                                      
REMARK 465     PRO B   136                                                      
REMARK 465     HIS B   137                                                      
REMARK 465     ASP B   138                                                      
REMARK 465     LEU B   139                                                      
REMARK 465     ILE B   140                                                      
REMARK 465     ILE B   141                                                      
REMARK 465     GLY B   142                                                      
REMARK 465     THR B   143                                                      
REMARK 465     ALA B   144                                                      
REMARK 465     ASP B   145                                                      
REMARK 465     ILE B   146                                                      
REMARK 465     PHE B   147                                                      
REMARK 465     ILE B   148                                                      
REMARK 465     ARG B   149                                                      
REMARK 465     GLN B   150                                                      
REMARK 465     LEU B   151                                                      
REMARK 465     LYS B   152                                                      
REMARK 465     GLU B   153                                                      
REMARK 465     ASN B   154                                                      
REMARK 465     GLU B   155                                                      
REMARK 465     GLU B   156                                                      
REMARK 465     ASN B   157                                                      
REMARK 465     GLU B   158                                                      
REMARK 465     ASP B   159                                                      
REMARK 465     GLY B   160                                                      
REMARK 465     ASN B   161                                                      
REMARK 465     ILE B   162                                                      
REMARK 465     GLU B   163                                                      
REMARK 465     GLU B   164                                                      
REMARK 465     ARG B   165                                                      
REMARK 465     LYS B   166                                                      
REMARK 465     GLU B   167                                                      
REMARK 465     LYS B   168                                                      
REMARK 465     ILE B   169                                                      
REMARK 465     GLN B   170                                                      
REMARK 465     HIS B   171                                                      
REMARK 465     GLU B   172                                                      
REMARK 465     LEU B   173                                                      
REMARK 465     GLY B   174                                                      
REMARK 465     ILE B   175                                                      
REMARK 465     ASN B   176                                                      
REMARK 465     ILE B   177                                                      
REMARK 465     ASP B   178                                                      
REMARK 465     SER B   179                                                      
REMARK 465     LEU B   180                                                      
REMARK 465     LYS B   181                                                      
REMARK 465     PHE B   182                                                      
REMARK 465     ASN B   183                                                      
REMARK 465     GLU B   184                                                      
REMARK 465     LEU B   185                                                      
REMARK 465     VAL B   186                                                      
REMARK 465     LYS B   187                                                      
REMARK 465     LEU B   188                                                      
REMARK 465     MET B   189                                                      
REMARK 465     LYS B   190                                                      
REMARK 465     ASN B   191                                                      
REMARK 465     ILE B   192                                                      
REMARK 465     THR B   193                                                      
REMARK 465     ASP B   194                                                      
REMARK 465     TYR B   195                                                      
REMARK 465     GLU B   196                                                      
REMARK 465     THR B   197                                                      
REMARK 465     HIS B   198                                                      
REMARK 465     PRO B   199                                                      
REMARK 465     ASP B   200                                                      
REMARK 465     ASN B   201                                                      
REMARK 465     SER B   202                                                      
REMARK 465     ASN B   203                                                      
REMARK 465     LYS B   204                                                      
REMARK 465     GLN B   205                                                      
REMARK 465     ALA B   206                                                      
REMARK 465     VAL B   207                                                      
REMARK 465     ALA B   208                                                      
REMARK 465     ILE B   209                                                      
REMARK 465     LEU B   210                                                      
REMARK 465     ALA B   211                                                      
REMARK 465     ASP B   212                                                      
REMARK 465     ASP B   213                                                      
REMARK 465     GLU B   214                                                      
REMARK 465     LYS B   215                                                      
REMARK 465     SER B   216                                                      
REMARK 465     ASP B   217                                                      
REMARK 465     GLU B   218                                                      
REMARK 465     GLU B   219                                                      
REMARK 465     GLU B   220                                                      
REMARK 465     VAL B   221                                                      
REMARK 465     THR B   222                                                      
REMARK 465     GLU B   223                                                      
REMARK 465     MET B   224                                                      
REMARK 465     SER B   225                                                      
REMARK 465     ASN B   226                                                      
REMARK 465     ASN B   227                                                      
REMARK 465     ALA B   228                                                      
REMARK 465     ASN B   229                                                      
REMARK 465     VAL B   230                                                      
REMARK 465     LEU B   231                                                      
REMARK 465     GLY B   232                                                      
REMARK 465     GLY B   233                                                      
REMARK 465     GLU B   234                                                      
REMARK 465     ILE B   235                                                      
REMARK 465     ASN B   236                                                      
REMARK 465     ASP B   237                                                      
REMARK 465     ASN B   238                                                      
REMARK 465     GLU B   239                                                      
REMARK 465     ASP B   240                                                      
REMARK 465     ASP B   241                                                      
REMARK 465     ASP B   242                                                      
REMARK 465     GLU B   243                                                      
REMARK 465     GLU B   244                                                      
REMARK 465     TYR B   245                                                      
REMARK 465     ASP B   246                                                      
REMARK 465     TYR B   247                                                      
REMARK 465     ASN B   248                                                      
REMARK 465     ASP B   249                                                      
REMARK 465     VAL B   250                                                      
REMARK 465     GLU B   251                                                      
REMARK 465     VAL B   252                                                      
REMARK 465     ASN B   253                                                      
REMARK 465     SER B   254                                                      
REMARK 465     LYS B   255                                                      
REMARK 465     LYS B   256                                                      
REMARK 465     LYS B   257                                                      
REMARK 465     ASN B   258                                                      
REMARK 465     LYS B   259                                                      
REMARK 465     ARG B   260                                                      
REMARK 465     ALA B   261                                                      
REMARK 465     LEU B   262                                                      
REMARK 465     PRO B   263                                                      
REMARK 465     ASN B   264                                                      
REMARK 465     ILE B   265                                                      
REMARK 465     GLU B   266                                                      
REMARK 465     ASN B   267                                                      
REMARK 465     ASP B   268                                                      
REMARK 465     ILE B   269                                                      
REMARK 465     ILE B   270                                                      
REMARK 465     LYS B   271                                                      
REMARK 465     LEU B   272                                                      
REMARK 465     SER B   273                                                      
REMARK 465     ASP B   274                                                      
REMARK 465     SER B   275                                                      
REMARK 465     LYS B   276                                                      
REMARK 465     THR B   277                                                      
REMARK 465     SER B   278                                                      
REMARK 465     ASN B   279                                                      
REMARK 465     ILE B   280                                                      
REMARK 465     GLU B   281                                                      
REMARK 465     SER B   282                                                      
REMARK 465     VAL B   283                                                      
REMARK 465     PRO B   284                                                      
REMARK 465     ILE B   285                                                      
REMARK 465     TYR B   286                                                      
REMARK 465     SER B   287                                                      
REMARK 465     ILE B   288                                                      
REMARK 465     ASP B   289                                                      
REMARK 465     GLU B   290                                                      
REMARK 465     PHE B   291                                                      
REMARK 465     PHE B   292                                                      
REMARK 465     LEU B   293                                                      
REMARK 465     GLN B   294                                                      
REMARK 465     ARG B   295                                                      
REMARK 465     LYS B   296                                                      
REMARK 465     LEU B   297                                                      
REMARK 465     ARG B   298                                                      
REMARK 465     SER B   299                                                      
REMARK 465     GLU B   300                                                      
REMARK 465     LEU B   301                                                      
REMARK 465     GLY B   302                                                      
REMARK 465     TYR B   303                                                      
REMARK 465     LYS B   304                                                      
REMARK 465     ASP B   305                                                      
REMARK 465     THR B   306                                                      
REMARK 465     SER B   307                                                      
REMARK 465     VAL B   308                                                      
REMARK 465     ILE B   309                                                      
REMARK 465     GLN B   310                                                      
REMARK 465     ASP B   311                                                      
REMARK 465     LEU B   312                                                      
REMARK 465     SER B   313                                                      
REMARK 465     GLU B   314                                                      
REMARK 465     LYS B   315                                                      
REMARK 465     ILE B   316                                                      
REMARK 465     LEU B   317                                                      
REMARK 465     ASN B   318                                                      
REMARK 465     ASP B   319                                                      
REMARK 465     ILE B   320                                                      
REMARK 465     GLU B   321                                                      
REMARK 465     THR B   322                                                      
REMARK 465     LEU B   323                                                      
REMARK 465     GLU B   324                                                      
REMARK 465     HIS B   325                                                      
REMARK 465     ASN B   326                                                      
REMARK 465     PRO B   327                                                      
REMARK 465     VAL B   328                                                      
REMARK 465     ALA B   329                                                      
REMARK 465     LEU B   330                                                      
REMARK 465     GLU B   331                                                      
REMARK 465     GLN B   332                                                      
REMARK 465     LYS B   333                                                      
REMARK 465     LEU B   334                                                      
REMARK 465     VAL B   335                                                      
REMARK 465     ASP B   336                                                      
REMARK 465     LEU B   337                                                      
REMARK 465     LEU B   338                                                      
REMARK 465     LYS B   339                                                      
REMARK 465     PHE B   340                                                      
REMARK 465     GLU B   341                                                      
REMARK 465     ASN B   342                                                      
REMARK 465     ILE B   343                                                      
REMARK 465     SER B   344                                                      
REMARK 465     LEU B   345                                                      
REMARK 465     ALA B   346                                                      
REMARK 465     GLU B   347                                                      
REMARK 465     PHE B   348                                                      
REMARK 465     ILE B   349                                                      
REMARK 465     LEU B   350                                                      
REMARK 465     LYS B   351                                                      
REMARK 465     ASN B   352                                                      
REMARK 465     ARG B   353                                                      
REMARK 465     SER B   354                                                      
REMARK 465     THR B   355                                                      
REMARK 465     ILE B   356                                                      
REMARK 465     PHE B   357                                                      
REMARK 465     TRP B   358                                                      
REMARK 465     GLY B   359                                                      
REMARK 465     ILE B   360                                                      
REMARK 465     ARG B   361                                                      
REMARK 465     LEU B   362                                                      
REMARK 465     PHE B   434                                                      
REMARK 465     ASP B   435                                                      
REMARK 465     GLU B   436                                                      
REMARK 465     SER B   437                                                      
REMARK 465     SER B   438                                                      
REMARK 465     GLU B  1826                                                      
REMARK 465     ALA B  1827                                                      
REMARK 465     GLU B  1828                                                      
REMARK 465     VAL B  1829                                                      
REMARK 465     THR B  1830                                                      
REMARK 465     ALA B  1831                                                      
REMARK 465     GLU B  1832                                                      
REMARK 465     VAL B  1833                                                      
REMARK 465     ASN B  1834                                                      
REMARK 465     GLY B  1835                                                      
REMARK 465     GLY B  1836                                                      
REMARK 465     ASP B  1837                                                      
REMARK 465     ASP B  1838                                                      
REMARK 465     GLU B  1839                                                      
REMARK 465     ALA B  1840                                                      
REMARK 465     MET k     1                                                      
REMARK 465     SER k     2                                                      
REMARK 465     LYS k     3                                                      
REMARK 465     THR k    56                                                      
REMARK 465     GLN k    57                                                      
REMARK 465     LEU k    58                                                      
REMARK 465     ASP k    59                                                      
REMARK 465     LYS k    60                                                      
REMARK 465     LEU k    61                                                      
REMARK 465     ARG k    62                                                      
REMARK 465     PRO k    63                                                      
REMARK 465     ARG k    64                                                      
REMARK 465     LYS k    65                                                      
REMARK 465     ASP k    66                                                      
REMARK 465     SER k    67                                                      
REMARK 465     LYS k    68                                                      
REMARK 465     ASP k    69                                                      
REMARK 465     GLY k    70                                                      
REMARK 465     THR k    71                                                      
REMARK 465     THR k    72                                                      
REMARK 465     LEU k    73                                                      
REMARK 465     ASN k    74                                                      
REMARK 465     LEU k   103                                                      
REMARK 465     SER k   104                                                      
REMARK 465     LYS k   105                                                      
REMARK 465     LYS k   106                                                      
REMARK 465     GLU k   107                                                      
REMARK 465     ARG k   108                                                      
REMARK 465     LEU k   109                                                      
REMARK 465     VAL k   110                                                      
REMARK 465     ARG k   111                                                      
REMARK 465     ASP k   112                                                      
REMARK 465     LYS k   113                                                      
REMARK 465     LYS k   114                                                      
REMARK 465     GLU k   115                                                      
REMARK 465     LYS k   116                                                      
REMARK 465     LYS k   117                                                      
REMARK 465     GLN k   118                                                      
REMARK 465     ALA k   119                                                      
REMARK 465     GLN k   120                                                      
REMARK 465     LYS k   121                                                      
REMARK 465     GLN k   122                                                      
REMARK 465     THR k   123                                                      
REMARK 465     LYS k   124                                                      
REMARK 465     LEU k   125                                                      
REMARK 465     ARG k   126                                                      
REMARK 465     LYS k   127                                                      
REMARK 465     GLU k   128                                                      
REMARK 465     LYS k   129                                                      
REMARK 465     GLU k   130                                                      
REMARK 465     LYS k   131                                                      
REMARK 465     LYS k   132                                                      
REMARK 465     PRO k   133                                                      
REMARK 465     GLY k   134                                                      
REMARK 465     LYS k   135                                                      
REMARK 465     ILE k   136                                                      
REMARK 465     ALA k   137                                                      
REMARK 465     LYS k   138                                                      
REMARK 465     PRO k   139                                                      
REMARK 465     ASN k   140                                                      
REMARK 465     THR k   141                                                      
REMARK 465     ALA k   142                                                      
REMARK 465     ASN k   143                                                      
REMARK 465     ALA k   144                                                      
REMARK 465     LYS k   145                                                      
REMARK 465     HIS k   146                                                      
REMARK 465     THR k   147                                                      
REMARK 465     SER k   148                                                      
REMARK 465     SER k   149                                                      
REMARK 465     ASN k   150                                                      
REMARK 465     SER k   151                                                      
REMARK 465     ARG k   152                                                      
REMARK 465     GLU k   153                                                      
REMARK 465     ILE k   154                                                      
REMARK 465     ALA k   155                                                      
REMARK 465     GLN k   156                                                      
REMARK 465     PRO k   157                                                      
REMARK 465     SER k   158                                                      
REMARK 465     SER k   159                                                      
REMARK 465     SER k   160                                                      
REMARK 465     ARG k   161                                                      
REMARK 465     TYR k   162                                                      
REMARK 465     ASN k   163                                                      
REMARK 465     GLY k   164                                                      
REMARK 465     GLY k   165                                                      
REMARK 465     ASN k   166                                                      
REMARK 465     ASP k   167                                                      
REMARK 465     ASN k   168                                                      
REMARK 465     ILE k   169                                                      
REMARK 465     GLY k   170                                                      
REMARK 465     ALA k   171                                                      
REMARK 465     ASN k   172                                                      
REMARK 465     ARG k   173                                                      
REMARK 465     SER k   174                                                      
REMARK 465     ARG k   175                                                      
REMARK 465     PHE k   176                                                      
REMARK 465     ASN k   177                                                      
REMARK 465     ASN k   178                                                      
REMARK 465     GLU k   179                                                      
REMARK 465     ALA k   180                                                      
REMARK 465     PRO k   181                                                      
REMARK 465     PRO k   182                                                      
REMARK 465     GLN k   183                                                      
REMARK 465     THR k   184                                                      
REMARK 465     ARG k   185                                                      
REMARK 465     LYS k   186                                                      
REMARK 465     PHE k   187                                                      
REMARK 465     GLN k   188                                                      
REMARK 465     PRO k   189                                                      
REMARK 465     PRO k   190                                                      
REMARK 465     PRO k   191                                                      
REMARK 465     GLY k   192                                                      
REMARK 465     PHE k   193                                                      
REMARK 465     LYS k   194                                                      
REMARK 465     ARG k   195                                                      
REMARK 465     LYS k   196                                                      
REMARK 465     GLN l    49                                                      
REMARK 465     PRO l    50                                                      
REMARK 465     ARG l    51                                                      
REMARK 465     LEU l    52                                                      
REMARK 465     ASN l    53                                                      
REMARK 465     LYS l    54                                                      
REMARK 465     LEU l    55                                                      
REMARK 465     ASN l    56                                                      
REMARK 465     SER l    57                                                      
REMARK 465     ASN l    58                                                      
REMARK 465     GLY l    59                                                      
REMARK 465     ILE l    60                                                      
REMARK 465     ALA l    61                                                      
REMARK 465     MET l    62                                                      
REMARK 465     ALA l    63                                                      
REMARK 465     SER l    64                                                      
REMARK 465     LEU l    65                                                      
REMARK 465     TYR l    66                                                      
REMARK 465     LEU l    67                                                      
REMARK 465     THR l    68                                                      
REMARK 465     GLY l    69                                                      
REMARK 465     GLY l    70                                                      
REMARK 465     GLN l    71                                                      
REMARK 465     GLN l    72                                                      
REMARK 465     PRO l    73                                                      
REMARK 465     THR l    74                                                      
REMARK 465     ALA l    75                                                      
REMARK 465     SER l   119                                                      
REMARK 465     GLY l   120                                                      
REMARK 465     GLN l   121                                                      
REMARK 465     ILE l   122                                                      
REMARK 465     ALA l   123                                                      
REMARK 465     ASN l   124                                                      
REMARK 465     ASP l   125                                                      
REMARK 465     PRO l   126                                                      
REMARK 465     SER l   127                                                      
REMARK 465     LYS l   128                                                      
REMARK 465     LYS l   129                                                      
REMARK 465     ARG l   130                                                      
REMARK 465     ARG l   131                                                      
REMARK 465     ARG l   132                                                      
REMARK 465     ASP l   133                                                      
REMARK 465     PHE l   134                                                      
REMARK 465     GLY l   135                                                      
REMARK 465     ALA l   136                                                      
REMARK 465     PRO l   137                                                      
REMARK 465     ALA l   138                                                      
REMARK 465     ASN l   139                                                      
REMARK 465     LYS l   140                                                      
REMARK 465     ARG l   141                                                      
REMARK 465     PRO l   142                                                      
REMARK 465     ARG l   143                                                      
REMARK 465     ARG l   144                                                      
REMARK 465     GLY l   145                                                      
REMARK 465     LEU l   146                                                      
REMARK 465     MET m     1                                                      
REMARK 465     SER m     2                                                      
REMARK 465     SER m     3                                                      
REMARK 465     GLN m     4                                                      
REMARK 465     ILE m     5                                                      
REMARK 465     ILE m     6                                                      
REMARK 465     ASP m     7                                                      
REMARK 465     ARG m     8                                                      
REMARK 465     PRO m     9                                                      
REMARK 465     LYS m    10                                                      
REMARK 465     HIS m    11                                                      
REMARK 465     GLU m    12                                                      
REMARK 465     LEU m    13                                                      
REMARK 465     SER m    14                                                      
REMARK 465     VAL m   109                                                      
REMARK 465     GLU m   110                                                      
REMARK 465     MET n     1                                                      
REMARK 465     THR n     2                                                      
REMARK 465     MET n     3                                                      
REMARK 465     LYS n    86                                                      
REMARK 465     ASN n    87                                                      
REMARK 465     SER n    88                                                      
REMARK 465     SER n    89                                                      
REMARK 465     ARG n    90                                                      
REMARK 465     PRO n    91                                                      
REMARK 465     MET n    92                                                      
REMARK 465     PRO n    93                                                      
REMARK 465     PRO n    94                                                      
REMARK 465     ILE n    95                                                      
REMARK 465     ARG n    96                                                      
REMARK 465     GLY n    97                                                      
REMARK 465     PRO n    98                                                      
REMARK 465     LYS n    99                                                      
REMARK 465     ARG n   100                                                      
REMARK 465     ARG n   101                                                      
REMARK 465     MET p     1                                                      
REMARK 465     SER p     2                                                      
REMARK 465     ASN p     3                                                      
REMARK 465     LYS p     4                                                      
REMARK 465     VAL p     5                                                      
REMARK 465     LYS p     6                                                      
REMARK 465     THR p     7                                                      
REMARK 465     LYS p     8                                                      
REMARK 465     ALA p     9                                                      
REMARK 465     ALA p    65                                                      
REMARK 465     ASP p    66                                                      
REMARK 465     GLY p    67                                                      
REMARK 465     LYS p    68                                                      
REMARK 465     GLU p    69                                                      
REMARK 465     ASP p    70                                                      
REMARK 465     VAL p    71                                                      
REMARK 465     GLU p    72                                                      
REMARK 465     ALA p    93                                                      
REMARK 465     ASP p    94                                                      
REMARK 465     MET q     1                                                      
REMARK 465     SER q     2                                                      
REMARK 465     GLU q     3                                                      
REMARK 465     SER q     4                                                      
REMARK 465     SER q     5                                                      
REMARK 465     ASP q     6                                                      
REMARK 465     ILE q     7                                                      
REMARK 465     SER q     8                                                      
REMARK 465     ALA q     9                                                      
REMARK 465     MET q    10                                                      
REMARK 465     GLN q    11                                                      
REMARK 465     LEU q    84                                                      
REMARK 465     PRO q    85                                                      
REMARK 465     ASN q    86                                                      
REMARK 465     MET r     1                                                      
REMARK 465     ASN r    47                                                      
REMARK 465     GLY r    48                                                      
REMARK 465     GLU r    49                                                      
REMARK 465     ASP r    50                                                      
REMARK 465     PRO r    51                                                      
REMARK 465     ALA r    52                                                      
REMARK 465     ILE r    77                                                      
REMARK 465     MET b     1                                                      
REMARK 465     SER b     2                                                      
REMARK 465     LYS b     3                                                      
REMARK 465     THR b    56                                                      
REMARK 465     GLN b    57                                                      
REMARK 465     LEU b    58                                                      
REMARK 465     ASP b    59                                                      
REMARK 465     LYS b    60                                                      
REMARK 465     LEU b    61                                                      
REMARK 465     ARG b    62                                                      
REMARK 465     PRO b    63                                                      
REMARK 465     ARG b    64                                                      
REMARK 465     LYS b    65                                                      
REMARK 465     ASP b    66                                                      
REMARK 465     SER b    67                                                      
REMARK 465     LYS b    68                                                      
REMARK 465     ASP b    69                                                      
REMARK 465     GLY b    70                                                      
REMARK 465     THR b    71                                                      
REMARK 465     THR b    72                                                      
REMARK 465     LEU b    73                                                      
REMARK 465     ASN b    74                                                      
REMARK 465     LEU b   103                                                      
REMARK 465     SER b   104                                                      
REMARK 465     LYS b   105                                                      
REMARK 465     LYS b   106                                                      
REMARK 465     GLU b   107                                                      
REMARK 465     ARG b   108                                                      
REMARK 465     LEU b   109                                                      
REMARK 465     VAL b   110                                                      
REMARK 465     ARG b   111                                                      
REMARK 465     ASP b   112                                                      
REMARK 465     LYS b   113                                                      
REMARK 465     LYS b   114                                                      
REMARK 465     GLU b   115                                                      
REMARK 465     LYS b   116                                                      
REMARK 465     LYS b   117                                                      
REMARK 465     GLN b   118                                                      
REMARK 465     ALA b   119                                                      
REMARK 465     GLN b   120                                                      
REMARK 465     LYS b   121                                                      
REMARK 465     GLN b   122                                                      
REMARK 465     THR b   123                                                      
REMARK 465     LYS b   124                                                      
REMARK 465     LEU b   125                                                      
REMARK 465     ARG b   126                                                      
REMARK 465     LYS b   127                                                      
REMARK 465     GLU b   128                                                      
REMARK 465     LYS b   129                                                      
REMARK 465     GLU b   130                                                      
REMARK 465     LYS b   131                                                      
REMARK 465     LYS b   132                                                      
REMARK 465     PRO b   133                                                      
REMARK 465     GLY b   134                                                      
REMARK 465     LYS b   135                                                      
REMARK 465     ILE b   136                                                      
REMARK 465     ALA b   137                                                      
REMARK 465     LYS b   138                                                      
REMARK 465     PRO b   139                                                      
REMARK 465     ASN b   140                                                      
REMARK 465     THR b   141                                                      
REMARK 465     ALA b   142                                                      
REMARK 465     ASN b   143                                                      
REMARK 465     ALA b   144                                                      
REMARK 465     LYS b   145                                                      
REMARK 465     HIS b   146                                                      
REMARK 465     THR b   147                                                      
REMARK 465     SER b   148                                                      
REMARK 465     SER b   149                                                      
REMARK 465     ASN b   150                                                      
REMARK 465     SER b   151                                                      
REMARK 465     ARG b   152                                                      
REMARK 465     GLU b   153                                                      
REMARK 465     ILE b   154                                                      
REMARK 465     ALA b   155                                                      
REMARK 465     GLN b   156                                                      
REMARK 465     PRO b   157                                                      
REMARK 465     SER b   158                                                      
REMARK 465     SER b   159                                                      
REMARK 465     SER b   160                                                      
REMARK 465     ARG b   161                                                      
REMARK 465     TYR b   162                                                      
REMARK 465     ASN b   163                                                      
REMARK 465     GLY b   164                                                      
REMARK 465     GLY b   165                                                      
REMARK 465     ASN b   166                                                      
REMARK 465     ASP b   167                                                      
REMARK 465     ASN b   168                                                      
REMARK 465     ILE b   169                                                      
REMARK 465     GLY b   170                                                      
REMARK 465     ALA b   171                                                      
REMARK 465     ASN b   172                                                      
REMARK 465     ARG b   173                                                      
REMARK 465     SER b   174                                                      
REMARK 465     ARG b   175                                                      
REMARK 465     PHE b   176                                                      
REMARK 465     ASN b   177                                                      
REMARK 465     ASN b   178                                                      
REMARK 465     GLU b   179                                                      
REMARK 465     ALA b   180                                                      
REMARK 465     PRO b   181                                                      
REMARK 465     PRO b   182                                                      
REMARK 465     GLN b   183                                                      
REMARK 465     THR b   184                                                      
REMARK 465     ARG b   185                                                      
REMARK 465     LYS b   186                                                      
REMARK 465     PHE b   187                                                      
REMARK 465     GLN b   188                                                      
REMARK 465     PRO b   189                                                      
REMARK 465     PRO b   190                                                      
REMARK 465     PRO b   191                                                      
REMARK 465     GLY b   192                                                      
REMARK 465     PHE b   193                                                      
REMARK 465     LYS b   194                                                      
REMARK 465     ARG b   195                                                      
REMARK 465     LYS b   196                                                      
REMARK 465     MET e     1                                                      
REMARK 465     SER e     2                                                      
REMARK 465     ASN e     3                                                      
REMARK 465     LYS e     4                                                      
REMARK 465     VAL e     5                                                      
REMARK 465     LYS e     6                                                      
REMARK 465     THR e     7                                                      
REMARK 465     LYS e     8                                                      
REMARK 465     ALA e     9                                                      
REMARK 465     ALA e    65                                                      
REMARK 465     ASP e    66                                                      
REMARK 465     GLY e    67                                                      
REMARK 465     LYS e    68                                                      
REMARK 465     GLU e    69                                                      
REMARK 465     ASP e    70                                                      
REMARK 465     VAL e    71                                                      
REMARK 465     GLU e    72                                                      
REMARK 465     ALA e    93                                                      
REMARK 465     ASP e    94                                                      
REMARK 465     MET f     1                                                      
REMARK 465     SER f     2                                                      
REMARK 465     GLU f     3                                                      
REMARK 465     SER f     4                                                      
REMARK 465     SER f     5                                                      
REMARK 465     ASP f     6                                                      
REMARK 465     ILE f     7                                                      
REMARK 465     SER f     8                                                      
REMARK 465     ALA f     9                                                      
REMARK 465     MET f    10                                                      
REMARK 465     GLN f    11                                                      
REMARK 465     LEU f    84                                                      
REMARK 465     PRO f    85                                                      
REMARK 465     ASN f    86                                                      
REMARK 465     MET g     1                                                      
REMARK 465     ASN g    47                                                      
REMARK 465     GLY g    48                                                      
REMARK 465     GLU g    49                                                      
REMARK 465     ASP g    50                                                      
REMARK 465     PRO g    51                                                      
REMARK 465     ALA g    52                                                      
REMARK 465     ILE g    77                                                      
REMARK 465     MET d     1                                                      
REMARK 465     THR d     2                                                      
REMARK 465     MET d     3                                                      
REMARK 465     LYS d    86                                                      
REMARK 465     ASN d    87                                                      
REMARK 465     SER d    88                                                      
REMARK 465     SER d    89                                                      
REMARK 465     ARG d    90                                                      
REMARK 465     PRO d    91                                                      
REMARK 465     MET d    92                                                      
REMARK 465     PRO d    93                                                      
REMARK 465     PRO d    94                                                      
REMARK 465     ILE d    95                                                      
REMARK 465     ARG d    96                                                      
REMARK 465     GLY d    97                                                      
REMARK 465     PRO d    98                                                      
REMARK 465     LYS d    99                                                      
REMARK 465     ARG d   100                                                      
REMARK 465     ARG d   101                                                      
REMARK 465     GLN h    49                                                      
REMARK 465     PRO h    50                                                      
REMARK 465     ARG h    51                                                      
REMARK 465     LEU h    52                                                      
REMARK 465     ASN h    53                                                      
REMARK 465     LYS h    54                                                      
REMARK 465     LEU h    55                                                      
REMARK 465     ASN h    56                                                      
REMARK 465     SER h    57                                                      
REMARK 465     ASN h    58                                                      
REMARK 465     GLY h    59                                                      
REMARK 465     ILE h    60                                                      
REMARK 465     ALA h    61                                                      
REMARK 465     MET h    62                                                      
REMARK 465     ALA h    63                                                      
REMARK 465     SER h    64                                                      
REMARK 465     LEU h    65                                                      
REMARK 465     TYR h    66                                                      
REMARK 465     LEU h    67                                                      
REMARK 465     THR h    68                                                      
REMARK 465     GLY h    69                                                      
REMARK 465     GLY h    70                                                      
REMARK 465     GLN h    71                                                      
REMARK 465     GLN h    72                                                      
REMARK 465     PRO h    73                                                      
REMARK 465     THR h    74                                                      
REMARK 465     ALA h    75                                                      
REMARK 465     GLN h   110                                                      
REMARK 465     LYS h   111                                                      
REMARK 465     GLN h   112                                                      
REMARK 465     LEU h   113                                                      
REMARK 465     ASN h   114                                                      
REMARK 465     SER h   115                                                      
REMARK 465     LEU h   116                                                      
REMARK 465     ARG h   117                                                      
REMARK 465     ARG h   118                                                      
REMARK 465     SER h   119                                                      
REMARK 465     GLY h   120                                                      
REMARK 465     GLN h   121                                                      
REMARK 465     ILE h   122                                                      
REMARK 465     ALA h   123                                                      
REMARK 465     ASN h   124                                                      
REMARK 465     ASP h   125                                                      
REMARK 465     PRO h   126                                                      
REMARK 465     SER h   127                                                      
REMARK 465     LYS h   128                                                      
REMARK 465     LYS h   129                                                      
REMARK 465     ARG h   130                                                      
REMARK 465     ARG h   131                                                      
REMARK 465     ARG h   132                                                      
REMARK 465     ASP h   133                                                      
REMARK 465     PHE h   134                                                      
REMARK 465     GLY h   135                                                      
REMARK 465     ALA h   136                                                      
REMARK 465     PRO h   137                                                      
REMARK 465     ALA h   138                                                      
REMARK 465     ASN h   139                                                      
REMARK 465     LYS h   140                                                      
REMARK 465     ARG h   141                                                      
REMARK 465     PRO h   142                                                      
REMARK 465     ARG h   143                                                      
REMARK 465     ARG h   144                                                      
REMARK 465     GLY h   145                                                      
REMARK 465     LEU h   146                                                      
REMARK 465     MET j     1                                                      
REMARK 465     SER j     2                                                      
REMARK 465     SER j     3                                                      
REMARK 465     GLN j     4                                                      
REMARK 465     ILE j     5                                                      
REMARK 465     ILE j     6                                                      
REMARK 465     ASP j     7                                                      
REMARK 465     ARG j     8                                                      
REMARK 465     PRO j     9                                                      
REMARK 465     LYS j    10                                                      
REMARK 465     HIS j    11                                                      
REMARK 465     GLU j    12                                                      
REMARK 465     LEU j    13                                                      
REMARK 465     SER j    14                                                      
REMARK 465     VAL j   109                                                      
REMARK 465     GLU j   110                                                      
REMARK 465       A U     1                                                      
REMARK 465       A U     2                                                      
REMARK 465       G U     3                                                      
REMARK 465       C U    54                                                      
REMARK 465       U U    55                                                      
REMARK 465       U U    56                                                      
REMARK 465       U U    57                                                      
REMARK 465       U U    58                                                      
REMARK 465       A U    59                                                      
REMARK 465       U U    60                                                      
REMARK 465       U U    61                                                      
REMARK 465       U U   145                                                      
REMARK 465       C U   146                                                      
REMARK 465       C U   147                                                      
REMARK 465       G U   148                                                      
REMARK 465       U U   149                                                      
REMARK 465       U U   150                                                      
REMARK 465       A U   151                                                      
REMARK 465       C U   152                                                      
REMARK 465       U U   153                                                      
REMARK 465       G U   154                                                      
REMARK 465       U U   155                                                      
REMARK 465       G U   156                                                      
REMARK 465       G U   157                                                      
REMARK 465       G U   158                                                      
REMARK 465       C U   159                                                      
REMARK 465       U U   160                                                      
REMARK 465       U U   161                                                      
REMARK 465       G U   162                                                      
REMARK 465       C U   163                                                      
REMARK 465       C U   164                                                      
REMARK 465       A U   165                                                      
REMARK 465       G U   174                                                      
REMARK 465       G U   175                                                      
REMARK 465       A U   176                                                      
REMARK 465       A U   177                                                      
REMARK 465       C U   178                                                      
REMARK 465       U U   179                                                      
REMARK 465       U U   180                                                      
REMARK 465       U U   181                                                      
REMARK 465       U U   182                                                      
REMARK 465       C U   183                                                      
REMARK 465       U U   184                                                      
REMARK 465       G U   185                                                      
REMARK 465       C U   186                                                      
REMARK 465       C U   187                                                      
REMARK 465       C U   188                                                      
REMARK 465       U U   189                                                      
REMARK 465       U U   190                                                      
REMARK 465       U U   191                                                      
REMARK 465       U U   192                                                      
REMARK 465       U U   193                                                      
REMARK 465       C U   194                                                      
REMARK 465       U U   195                                                      
REMARK 465       C U   196                                                      
REMARK 465       A U   197                                                      
REMARK 465       A U   198                                                      
REMARK 465       U U   199                                                      
REMARK 465       G U   200                                                      
REMARK 465       A U   201                                                      
REMARK 465       G U   202                                                      
REMARK 465       U U   203                                                      
REMARK 465       A U   204                                                      
REMARK 465       A U   205                                                      
REMARK 465       G U   206                                                      
REMARK 465       G U   207                                                      
REMARK 465       A U   208                                                      
REMARK 465       G U   209                                                      
REMARK 465       G U   210                                                      
REMARK 465       G U   211                                                      
REMARK 465       C U   212                                                      
REMARK 465       G U   213                                                      
REMARK 465       U U   214                                                      
REMARK 465     MET K     1                                                      
REMARK 465     SER K     2                                                      
REMARK 465     MET 2    91                                                      
REMARK 465     THR 2    92                                                      
REMARK 465     GLU 2    93                                                      
REMARK 465     ARG 2    94                                                      
REMARK 465     LYS 2    95                                                      
REMARK 465     MET 3     1                                                      
REMARK 465     GLU 3     2                                                      
REMARK 465     SER 3    80                                                      
REMARK 465     GLU 3    81                                                      
REMARK 465     ASP 3    82                                                      
REMARK 465     ASP 3    83                                                      
REMARK 465     ASP 3    84                                                      
REMARK 465     GLY 3    85                                                      
REMARK 465     ALA 3    86                                                      
REMARK 465     VAL 3    87                                                      
REMARK 465     GLU 3    88                                                      
REMARK 465     ILE 3    89                                                      
REMARK 465     GLU 4    48                                                      
REMARK 465     GLU 4    49                                                      
REMARK 465     SER 4    50                                                      
REMARK 465     ALA 4    51                                                      
REMARK 465     ILE 4    52                                                      
REMARK 465     ASN 4    53                                                      
REMARK 465     SER 4    54                                                      
REMARK 465     GLU 4    55                                                      
REMARK 465     ASP 4    56                                                      
REMARK 465     ASN 4    57                                                      
REMARK 465     ALA 4    58                                                      
REMARK 465     GLU 4    59                                                      
REMARK 465     SER 4    60                                                      
REMARK 465     SER 4    61                                                      
REMARK 465     LYS 4    62                                                      
REMARK 465     ALA 4    63                                                      
REMARK 465     GLN 4    91                                                      
REMARK 465     GLN 4    92                                                      
REMARK 465     ILE 4    93                                                      
REMARK 465     ASN 4    94                                                      
REMARK 465     SER 4    95                                                      
REMARK 465     ASN 4    96                                                      
REMARK 465     ASN 4    97                                                      
REMARK 465     ASN 4    98                                                      
REMARK 465     SER 4    99                                                      
REMARK 465     ASN 4   100                                                      
REMARK 465     SER 4   101                                                      
REMARK 465     ASN 4   102                                                      
REMARK 465     GLY 4   103                                                      
REMARK 465     PRO 4   104                                                      
REMARK 465     GLY 4   105                                                      
REMARK 465     HIS 4   106                                                      
REMARK 465     LYS 4   107                                                      
REMARK 465     ARG 4   108                                                      
REMARK 465     TYR 4   109                                                      
REMARK 465     TYR 4   110                                                      
REMARK 465     ASN 4   111                                                      
REMARK 465     ASN 4   112                                                      
REMARK 465     ARG 4   113                                                      
REMARK 465     ASP 4   114                                                      
REMARK 465     SER 4   115                                                      
REMARK 465     ASN 4   116                                                      
REMARK 465     ASN 4   117                                                      
REMARK 465     ASN 4   118                                                      
REMARK 465     ARG 4   119                                                      
REMARK 465     GLY 4   120                                                      
REMARK 465     ASN 4   121                                                      
REMARK 465     TYR 4   122                                                      
REMARK 465     ASN 4   123                                                      
REMARK 465     ARG 4   124                                                      
REMARK 465     ARG 4   125                                                      
REMARK 465     ASN 4   126                                                      
REMARK 465     ASN 4   127                                                      
REMARK 465     ASN 4   128                                                      
REMARK 465     ASN 4   129                                                      
REMARK 465     GLY 4   130                                                      
REMARK 465     ASN 4   131                                                      
REMARK 465     SER 4   132                                                      
REMARK 465     ASN 4   133                                                      
REMARK 465     ARG 4   134                                                      
REMARK 465     ARG 4   135                                                      
REMARK 465     PRO 4   136                                                      
REMARK 465     TYR 4   137                                                      
REMARK 465     SER 4   138                                                      
REMARK 465     GLN 4   139                                                      
REMARK 465     ASN 4   140                                                      
REMARK 465     ARG 4   141                                                      
REMARK 465     GLN 4   142                                                      
REMARK 465     TYR 4   143                                                      
REMARK 465     ASN 4   144                                                      
REMARK 465     ASN 4   145                                                      
REMARK 465     SER 4   146                                                      
REMARK 465     ASN 4   147                                                      
REMARK 465     SER 4   148                                                      
REMARK 465     SER 4   149                                                      
REMARK 465     ASN 4   150                                                      
REMARK 465     ILE 4   151                                                      
REMARK 465     ASN 4   152                                                      
REMARK 465     ASN 4   153                                                      
REMARK 465     SER 4   154                                                      
REMARK 465     ILE 4   155                                                      
REMARK 465     ASN 4   156                                                      
REMARK 465     SER 4   157                                                      
REMARK 465     ILE 4   158                                                      
REMARK 465     ASN 4   159                                                      
REMARK 465     SER 4   160                                                      
REMARK 465     ASN 4   161                                                      
REMARK 465     ASN 4   162                                                      
REMARK 465     GLN 4   163                                                      
REMARK 465     ASN 4   164                                                      
REMARK 465     MET 4   165                                                      
REMARK 465     ASN 4   166                                                      
REMARK 465     ASN 4   167                                                      
REMARK 465     GLY 4   168                                                      
REMARK 465     LEU 4   169                                                      
REMARK 465     GLY 4   170                                                      
REMARK 465     GLY 4   171                                                      
REMARK 465     SER 4   172                                                      
REMARK 465     VAL 4   173                                                      
REMARK 465     GLN 4   174                                                      
REMARK 465     HIS 4   175                                                      
REMARK 465     HIS 4   176                                                      
REMARK 465     PHE 4   177                                                      
REMARK 465     ASN 4   178                                                      
REMARK 465     SER 4   179                                                      
REMARK 465     SER 4   180                                                      
REMARK 465     SER 4   181                                                      
REMARK 465     PRO 4   182                                                      
REMARK 465     GLN 4   183                                                      
REMARK 465     LYS 4   184                                                      
REMARK 465     VAL 4   185                                                      
REMARK 465     GLU 4   186                                                      
REMARK 465     PHE 4   187                                                      
REMARK 465     MET 5     1                                                      
REMARK 465     SER 5     2                                                      
REMARK 465     LEU 5     3                                                      
REMARK 465     PRO 5    55                                                      
REMARK 465     GLU 5    56                                                      
REMARK 465     ASP 5    57                                                      
REMARK 465     GLU 5    58                                                      
REMARK 465     SER 5    59                                                      
REMARK 465     ARG 5    60                                                      
REMARK 465     GLY 5    85                                                      
REMARK 465     LYS 5    86                                                      
REMARK 465     LYS 5    87                                                      
REMARK 465     THR 5    88                                                      
REMARK 465     PRO 5    89                                                      
REMARK 465     THR 5    90                                                      
REMARK 465     GLU 5    91                                                      
REMARK 465     ALA 5    92                                                      
REMARK 465     LEU 5    93                                                      
REMARK 465     MET 6     1                                                      
REMARK 465     SER 6     2                                                      
REMARK 465     GLY 6     3                                                      
REMARK 465     LYS 6     4                                                      
REMARK 465     ALA 6     5                                                      
REMARK 465     SER 6     6                                                      
REMARK 465     THR 6     7                                                      
REMARK 465     GLU 6     8                                                      
REMARK 465     GLY 6     9                                                      
REMARK 465     SER 6    10                                                      
REMARK 465     LYS 6    85                                                      
REMARK 465     ILE 6    86                                                      
REMARK 465     MET 7     1                                                      
REMARK 465     HIS 7     2                                                      
REMARK 465     GLN 7     3                                                      
REMARK 465     GLN 7     4                                                      
REMARK 465     HIS 7     5                                                      
REMARK 465     SER 7     6                                                      
REMARK 465     LYS 7     7                                                      
REMARK 465     SER 7     8                                                      
REMARK 465     GLU 7     9                                                      
REMARK 465     ASN 7    10                                                      
REMARK 465     LYS 7    11                                                      
REMARK 465     PRO 7    12                                                      
REMARK 465     GLN 7    13                                                      
REMARK 465     GLN 7    14                                                      
REMARK 465     GLN 7    15                                                      
REMARK 465     ARG 7    16                                                      
REMARK 465     LYS 7    17                                                      
REMARK 465     LYS 7    18                                                      
REMARK 465     PHE 7    19                                                      
REMARK 465     GLU 7    20                                                      
REMARK 465     GLY 7    21                                                      
REMARK 465     PRO 7    22                                                      
REMARK 465     LYS 7    23                                                      
REMARK 465     ARG 7    24                                                      
REMARK 465     GLU 7    25                                                      
REMARK 465     SER 7    71                                                      
REMARK 465     ASN 7    72                                                      
REMARK 465     PRO 7    73                                                      
REMARK 465     ASP 7    74                                                      
REMARK 465     ASP 7    75                                                      
REMARK 465     GLU 7    76                                                      
REMARK 465     ASN 7    77                                                      
REMARK 465     ASN 7    78                                                      
REMARK 465     THR 7    79                                                      
REMARK 465     GLU 7    80                                                      
REMARK 465     LEU 7    81                                                      
REMARK 465     ILE 7    82                                                      
REMARK 465     SER 7    83                                                      
REMARK 465     LYS 7    84                                                      
REMARK 465     GLU 7   106                                                      
REMARK 465     GLY 7   107                                                      
REMARK 465     SER 7   108                                                      
REMARK 465     ASP 7   109                                                      
REMARK 465     VAL 7   110                                                      
REMARK 465     LEU 7   111                                                      
REMARK 465     TYR 7   112                                                      
REMARK 465     MET 7   113                                                      
REMARK 465     GLN 7   114                                                      
REMARK 465     LYS 7   115                                                      
REMARK 465     MET 8     1                                                      
REMARK 465     SER 8     2                                                      
REMARK 465     ALA 8     3                                                      
REMARK 465     ASP 8    68                                                      
REMARK 465     ALA 8    69                                                      
REMARK 465     GLU 8    70                                                      
REMARK 465     ASN 8    71                                                      
REMARK 465     ASP 8    72                                                      
REMARK 465     ASP 8    73                                                      
REMARK 465     SER 8    74                                                      
REMARK 465     LEU 8    75                                                      
REMARK 465     ALA 8    76                                                      
REMARK 465     PRO 8    77                                                      
REMARK 465     ILE 8    78                                                      
REMARK 465     ASP 8    79                                                      
REMARK 465     GLU 8    80                                                      
REMARK 465     LYS 8    81                                                      
REMARK 465     LYS 8    82                                                      
REMARK 465     VAL 8    83                                                      
REMARK 465     PRO 8    84                                                      
REMARK 465     MET 8    85                                                      
REMARK 465     LEU 8    86                                                      
REMARK 465     LYS 8    87                                                      
REMARK 465     ASP 8    88                                                      
REMARK 465     THR 8    89                                                      
REMARK 465     LYS 8    90                                                      
REMARK 465     ASN 8    91                                                      
REMARK 465     LYS 8    92                                                      
REMARK 465     ILE 8    93                                                      
REMARK 465     GLU 8    94                                                      
REMARK 465     ASN 8    95                                                      
REMARK 465     GLU 8    96                                                      
REMARK 465     HIS 8    97                                                      
REMARK 465     VAL 8    98                                                      
REMARK 465     ILE 8    99                                                      
REMARK 465     TRP 8   100                                                      
REMARK 465     GLU 8   101                                                      
REMARK 465     LYS 8   102                                                      
REMARK 465     VAL 8   103                                                      
REMARK 465     TYR 8   104                                                      
REMARK 465     GLU 8   105                                                      
REMARK 465     SER 8   106                                                      
REMARK 465     LYS 8   107                                                      
REMARK 465     THR 8   108                                                      
REMARK 465     LYS 8   109                                                      
REMARK 465     MET C     1                                                      
REMARK 465     GLU C     2                                                      
REMARK 465     GLY C     3                                                      
REMARK 465     ASP C     4                                                      
REMARK 465     ASP C     5                                                      
REMARK 465     LEU C     6                                                      
REMARK 465     PHE C     7                                                      
REMARK 465     ASP C     8                                                      
REMARK 465     GLU C     9                                                      
REMARK 465     PHE C    10                                                      
REMARK 465     GLY C    11                                                      
REMARK 465     ASN C    12                                                      
REMARK 465     LEU C    13                                                      
REMARK 465     ILE C    14                                                      
REMARK 465     GLY C    15                                                      
REMARK 465     VAL C    16                                                      
REMARK 465     ASP C    17                                                      
REMARK 465     PRO C    18                                                      
REMARK 465     PHE C    19                                                      
REMARK 465     ASP C    20                                                      
REMARK 465     SER C    21                                                      
REMARK 465     ASP C    22                                                      
REMARK 465     GLU C    23                                                      
REMARK 465     GLU C    24                                                      
REMARK 465     GLU C    25                                                      
REMARK 465     SER C    26                                                      
REMARK 465     VAL C    27                                                      
REMARK 465     LEU C    28                                                      
REMARK 465     ASP C    29                                                      
REMARK 465     GLU C    30                                                      
REMARK 465     GLN C    31                                                      
REMARK 465     GLU C    32                                                      
REMARK 465     GLN C    33                                                      
REMARK 465     TYR C    34                                                      
REMARK 465     GLN C    35                                                      
REMARK 465     THR C    36                                                      
REMARK 465     ASN C    37                                                      
REMARK 465     THR C    38                                                      
REMARK 465     PHE C    39                                                      
REMARK 465     GLU C    40                                                      
REMARK 465     GLY C    41                                                      
REMARK 465     SER C    42                                                      
REMARK 465     GLY C    43                                                      
REMARK 465     ASN C    44                                                      
REMARK 465     ASN C    45                                                      
REMARK 465     ASN C    46                                                      
REMARK 465     GLU C    47                                                      
REMARK 465     ILE C    48                                                      
REMARK 465     GLU C    49                                                      
REMARK 465     SER C    50                                                      
REMARK 465     ARG C    51                                                      
REMARK 465     GLN C    52                                                      
REMARK 465     LEU C    53                                                      
REMARK 465     THR C    54                                                      
REMARK 465     SER C    55                                                      
REMARK 465     LEU C    56                                                      
REMARK 465     GLY C    57                                                      
REMARK 465     SER C    58                                                      
REMARK 465     LYS C    59                                                      
REMARK 465     LYS C    60                                                      
REMARK 465     GLU C    61                                                      
REMARK 465     LEU C    62                                                      
REMARK 465     GLY C    63                                                      
REMARK 465     ILE C    64                                                      
REMARK 465     SER C    65                                                      
REMARK 465     LEU C    66                                                      
REMARK 465     GLU C    67                                                      
REMARK 465     HIS C    68                                                      
REMARK 465     PRO C    69                                                      
REMARK 465     TYR C    70                                                      
REMARK 465     GLY C    71                                                      
REMARK 465     LYS C    72                                                      
REMARK 465     GLU C    73                                                      
REMARK 465     VAL C    74                                                      
REMARK 465     GLU C    75                                                      
REMARK 465     VAL C    76                                                      
REMARK 465     LEU C    77                                                      
REMARK 465     MET C    78                                                      
REMARK 465     GLU C    79                                                      
REMARK 465     THR C    80                                                      
REMARK 465     LYS C    81                                                      
REMARK 465     ASN C    82                                                      
REMARK 465     THR C    83                                                      
REMARK 465     GLN C    84                                                      
REMARK 465     SER C    85                                                      
REMARK 465     PRO C    86                                                      
REMARK 465     GLN C    87                                                      
REMARK 465     THR C    88                                                      
REMARK 465     PRO C    89                                                      
REMARK 465     LEU C    90                                                      
REMARK 465     VAL C    91                                                      
REMARK 465     GLU C    92                                                      
REMARK 465     PRO C    93                                                      
REMARK 465     VAL C    94                                                      
REMARK 465     THR C    95                                                      
REMARK 465     GLU C    96                                                      
REMARK 465     ARG C    97                                                      
REMARK 465     THR C    98                                                      
REMARK 465     LYS C    99                                                      
REMARK 465     LEU C   100                                                      
REMARK 465     GLN C   101                                                      
REMARK 465     SER C   519                                                      
REMARK 465     LYS C   520                                                      
REMARK 465     THR C   521                                                      
REMARK 465     GLU C   522                                                      
REMARK 465     THR C   523                                                      
REMARK 465     SER C   524                                                      
REMARK 465     ASN C   525                                                      
REMARK 465     GLU C   526                                                      
REMARK 465     ASP C   527                                                      
REMARK 465     GLU C   528                                                      
REMARK 465     ASP C   529                                                      
REMARK 465     SER C   694                                                      
REMARK 465     ILE C   695                                                      
REMARK 465     SER C   696                                                      
REMARK 465     ARG C   697                                                      
REMARK 465     LEU C   698                                                      
REMARK 465     GLY C   699                                                      
REMARK 465     GLU C   700                                                      
REMARK 465     GLU C   701                                                      
REMARK 465     ASN C   702                                                      
REMARK 465     LEU C   703                                                      
REMARK 465     PRO C   704                                                      
REMARK 465     GLY C   705                                                      
REMARK 465     LEU C   706                                                      
REMARK 465     ASN C   726                                                      
REMARK 465     THR C   727                                                      
REMARK 465     LEU C   728                                                      
REMARK 465     GLY C   729                                                      
REMARK 465     LYS C   730                                                      
REMARK 465     GLY C   731                                                      
REMARK 465     GLN C   732                                                      
REMARK 465     ASN C   733                                                      
REMARK 465     CYS C   734                                                      
REMARK 465     LEU C   735                                                      
REMARK 465     ASP C   736                                                      
REMARK 465     ILE C   737                                                      
REMARK 465     ASP C   738                                                      
REMARK 465     GLY C   739                                                      
REMARK 465     ILE C   740                                                      
REMARK 465     MET C   741                                                      
REMARK 465     ASP C   742                                                      
REMARK 465     ASN C   743                                                      
REMARK 465     ALA C   999                                                      
REMARK 465     GLN C  1000                                                      
REMARK 465     LEU C  1001                                                      
REMARK 465     ARG C  1002                                                      
REMARK 465     GLU C  1003                                                      
REMARK 465     ASN C  1004                                                      
REMARK 465     GLY C  1005                                                      
REMARK 465     LEU C  1006                                                      
REMARK 465     VAL C  1007                                                      
REMARK 465     PRO C  1008                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A 110    CG   CD   CE   NZ                                   
REMARK 470     ARG A 112    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 113    CG   CD   CE   NZ                                   
REMARK 470     ARG A 114    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 117    CG   CD   CE   NZ                                   
REMARK 470     MET A 118    CG   SD   CE                                        
REMARK 470     LYS A 120    CG   CD   CE   NZ                                   
REMARK 470     LYS A 121    CG   CD   CE   NZ                                   
REMARK 470     LYS A 123    CG   CD   CE   NZ                                   
REMARK 470     ASP A 148    CG   OD1  OD2                                       
REMARK 470     ASP A 157    CG   OD1  OD2                                       
REMARK 470     LYS A 158    CG   CD   CE   NZ                                   
REMARK 470     LYS A 159    CG   CD   CE   NZ                                   
REMARK 470     GLU A 227    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 230    CG   OD1  OD2                                       
REMARK 470     ARG A 231    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS A 233    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS A 235    CG   CD   CE   NZ                                   
REMARK 470     ARG A 236    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP A 243    CG   OD1  OD2                                       
REMARK 470     ASP A 244    CG   OD1  OD2                                       
REMARK 470     ASP A 245    CG   OD1  OD2                                       
REMARK 470     GLU A 246    CG   CD   OE1  OE2                                  
REMARK 470     ILE A 258    CG1  CG2  CD1                                       
REMARK 470     GLU A 259    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 262    CG   OD1  OD2                                       
REMARK 470     GLU A 274    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 291    CG   CD   CE   NZ                                   
REMARK 470     GLU A 321    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 358    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 359    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 360    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 361    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 362    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 363    CG   OD1  OD2                                       
REMARK 470     GLU A 366    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 413    CG   OD1  ND2                                       
REMARK 470     GLU A 415    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 464    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 465    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 508    CG   CD   OE1  NE2                                  
REMARK 470     GLU A 512    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 513    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 546    CG   CD   CE   NZ                                   
REMARK 470     LYS A 549    CG   CD   CE   NZ                                   
REMARK 470     LYS A 552    CG   CD   CE   NZ                                   
REMARK 470     ASN A 553    CG   OD1  ND2                                       
REMARK 470     LYS A 555    CG   CD   CE   NZ                                   
REMARK 470     GLU A 566    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 573    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 586    CG   CD   CE   NZ                                   
REMARK 470     LYS A 603    CG   CD   CE   NZ                                   
REMARK 470     LYS A 608    CG   CD   CE   NZ                                   
REMARK 470     GLU A 609    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 611    CG   CD   CE   NZ                                   
REMARK 470     LYS A 612    CG   CD   CE   NZ                                   
REMARK 470     GLU A 624    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 732    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN A 733    CG   CD   OE1  NE2                                  
REMARK 470     PHE A 734    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU A 735    CG   CD   OE1  OE2                                  
REMARK 470     ASN A1281    CG   OD1  ND2                                       
REMARK 470     GLN A2076    CG   CD   OE1  NE2                                  
REMARK 470     GLU A2316    CG   CD   OE1  OE2                                  
REMARK 470     GLU A2317    CG   CD   OE1  OE2                                  
REMARK 470     GLU A2327    CG   CD   OE1  OE2                                  
REMARK 470     GLU A2330    CG   CD   OE1  OE2                                  
REMARK 470     GLU A2397    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 252    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 267    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU H 345    CG   CD1  CD2                                       
REMARK 470     LYS H 350    CG   CD   CE   NZ                                   
REMARK 470     GLU J 165    CG   CD   OE1  OE2                                  
REMARK 470     ARG J 166    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU J 167    CG   CD   OE1  OE2                                  
REMARK 470     LYS J 168    CG   CD   CE   NZ                                   
REMARK 470     GLU J 176    CG   CD   OE1  OE2                                  
REMARK 470     GLN J 180    CG   CD   OE1  NE2                                  
REMARK 470     LYS J 205    CG   CD   CE   NZ                                   
REMARK 470     ASP J 206    CG   OD1  OD2                                       
REMARK 470     ARG J 211    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP J 217    CG   OD1  OD2                                       
REMARK 470     GLU J 348    CG   CD   OE1  OE2                                  
REMARK 470     LYS J 351    CG   CD   CE   NZ                                   
REMARK 470     ASN J 412    CG   OD1  ND2                                       
REMARK 470     LYS J 420    CG   CD   CE   NZ                                   
REMARK 470     LYS J 438    CG   CD   CE   NZ                                   
REMARK 470     LEU J 441    CG   CD1  CD2                                       
REMARK 470     LYS J 446    CG   CD   CE   NZ                                   
REMARK 470     ARG J 447    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU J 449    CG   CD   OE1  OE2                                  
REMARK 470     ASN J 452    CG   OD1  ND2                                       
REMARK 470     GLU J 477    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 479    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 481    CG   CD   OE1  OE2                                  
REMARK 470     HIS J 494    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TYR J 526    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN J 572    CG   CD   OE1  NE2                                  
REMARK 470     LYS J 573    CG   CD   CE   NZ                                   
REMARK 470     ASN J 593    CG   OD1  ND2                                       
REMARK 470     PHE J 627    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS J 628    CG   CD   CE   NZ                                   
REMARK 470     ILE J 629    CG1  CG2  CD1                                       
REMARK 470     GLU J 633    CG   CD   OE1  OE2                                  
REMARK 470     ARG J 634    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP J 727    CG   OD1  OD2                                       
REMARK 470     GLU F  49    CG   CD   OE1  OE2                                  
REMARK 470     ARG F  64    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU F  69    CG   CD   OE1  OE2                                  
REMARK 470     GLN F  72    CG   CD   OE1  NE2                                  
REMARK 470     ASP F  79    CG   OD1  OD2                                       
REMARK 470     PHE F  91    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ILE F  92    CG1  CG2  CD1                                       
REMARK 470     LYS F  93    CG   CD   CE   NZ                                   
REMARK 470     GLU F 126    CG   CD   OE1  OE2                                  
REMARK 470     LYS F 164    CG   CD   CE   NZ                                   
REMARK 470     LYS F 166    CG   CD   CE   NZ                                   
REMARK 470     GLU F 170    CG   CD   OE1  OE2                                  
REMARK 470     MET F 177    CG   SD   CE                                        
REMARK 470     LYS F 180    CG   CD   CE   NZ                                   
REMARK 470     THR F 195    OG1  CG2                                            
REMARK 470     GLU F 205    CG   CD   OE1  OE2                                  
REMARK 470     ASP F 213    CG   OD1  OD2                                       
REMARK 470     GLU F 236    CG   CD   OE1  OE2                                  
REMARK 470     GLU F 250    CG   CD   OE1  OE2                                  
REMARK 470     GLU F 282    CG   CD   OE1  OE2                                  
REMARK 470     ASP F 289    CG   OD1  OD2                                       
REMARK 470     LYS F 321    CG   CD   CE   NZ                                   
REMARK 470     GLU F 360    CG   CD   OE1  OE2                                  
REMARK 470     ASP F 361    CG   OD1  OD2                                       
REMARK 470     ASP G 170    CG   OD1  OD2                                       
REMARK 470     GLU G 176    CG   CD   OE1  OE2                                  
REMARK 470     LYS G 177    CG   CD   CE   NZ                                   
REMARK 470     GLU G 179    CG   CD   OE1  OE2                                  
REMARK 470     LYS G 183    CG   CD   CE   NZ                                   
REMARK 470     GLU G 227    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 367    CG   CD   OE1  OE2                                  
REMARK 470     GLN B 388    CG   CD   OE1  NE2                                  
REMARK 470     TYR B 389    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ARG B 392    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B 393    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 398    CG   CD   CE   NZ                                   
REMARK 470     ARG B 399    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B 400    CG   CD   OE1  OE2                                  
REMARK 470     GLN B 409    CG   CD   OE1  NE2                                  
REMARK 470     GLU B 450    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 851    CG   OD1  OD2                                       
REMARK 470     ASP B1553    CG   OD1  OD2                                       
REMARK 470     GLU B1555    CG   CD   OE1  OE2                                  
REMARK 470     LYS k  55    CG   CD   CE   NZ                                   
REMARK 470     GLU k  98    CG   CD   OE1  OE2                                  
REMARK 470     ASP k  99    CG   OD1  OD2                                       
REMARK 470     ASP l  99    CG   OD1  OD2                                       
REMARK 470     GLU m  19    CG   CD   OE1  OE2                                  
REMARK 470     GLU m  20    CG   CD   OE1  OE2                                  
REMARK 470     GLU m  22    CG   CD   OE1  OE2                                  
REMARK 470     GLU m  23    CG   CD   OE1  OE2                                  
REMARK 470     GLU m  25    CG   CD   OE1  OE2                                  
REMARK 470     ASP m  36    CG   OD1  OD2                                       
REMARK 470     GLU m  74    CG   CD   OE1  OE2                                  
REMARK 470     LYS m  79    CG   CD   CE   NZ                                   
REMARK 470     GLU m  88    CG   CD   OE1  OE2                                  
REMARK 470     GLU n  13    CG   CD   OE1  OE2                                  
REMARK 470     ASP n  46    CG   OD1  OD2                                       
REMARK 470     GLU p  56    CG   CD   OE1  OE2                                  
REMARK 470     GLU p  59    CG   CD   OE1  OE2                                  
REMARK 470     LYS p  73    CG   CD   CE   NZ                                   
REMARK 470     GLU q  37    CG   CD   OE1  OE2                                  
REMARK 470     GLU r   6    CG   CD   OE1  OE2                                  
REMARK 470     ASP r  41    CG   OD1  OD2                                       
REMARK 470     ASP r  42    CG   OD1  OD2                                       
REMARK 470     LYS b  55    CG   CD   CE   NZ                                   
REMARK 470     GLU b  98    CG   CD   OE1  OE2                                  
REMARK 470     ASP b  99    CG   OD1  OD2                                       
REMARK 470     GLU e  56    CG   CD   OE1  OE2                                  
REMARK 470     GLU e  59    CG   CD   OE1  OE2                                  
REMARK 470     LYS e  73    CG   CD   CE   NZ                                   
REMARK 470     GLU f  37    CG   CD   OE1  OE2                                  
REMARK 470     GLU g   6    CG   CD   OE1  OE2                                  
REMARK 470     ASP g  42    CG   OD1  OD2                                       
REMARK 470     GLU d  13    CG   CD   OE1  OE2                                  
REMARK 470     ASP d  46    CG   OD1  OD2                                       
REMARK 470     GLU j  19    CG   CD   OE1  OE2                                  
REMARK 470     GLU j  20    CG   CD   OE1  OE2                                  
REMARK 470     GLU j  22    CG   CD   OE1  OE2                                  
REMARK 470     GLU j  23    CG   CD   OE1  OE2                                  
REMARK 470     GLU j  25    CG   CD   OE1  OE2                                  
REMARK 470     ASP j  36    CG   OD1  OD2                                       
REMARK 470     GLU j  74    CG   CD   OE1  OE2                                  
REMARK 470     GLU j  88    CG   CD   OE1  OE2                                  
REMARK 470     LYS 2  49    CG   CD   CE   NZ                                   
REMARK 470     SER 4  47    OG                                                  
REMARK 470     ASP 4  87    CG   OD1  OD2                                       
REMARK 470     LYS 4  88    CG   CD   CE   NZ                                   
REMARK 470     VAL 4  89    CG1  CG2                                            
REMARK 470     LYS 4  90    CG   CD   CE   NZ                                   
REMARK 470     PRO 5   4    CG   CD                                             
REMARK 470     GLU 5   5    CG   CD   OE1  OE2                                  
REMARK 470     PHE 8  42    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU C 102    CG   CD   OE1  OE2                                  
REMARK 470     HIS C 103    CG   ND1  CD2  CE1  NE2                             
REMARK 470     THR C 104    OG1  CG2                                            
REMARK 470     ASN C 119    CG   OD1  ND2                                       
REMARK 470     ASP C 121    CG   OD1  OD2                                       
REMARK 470     MET C 123    CG   SD   CE                                        
REMARK 470     ASN C 128    CG   OD1  ND2                                       
REMARK 470     GLU C 131    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 151    CG   OD1  OD2                                       
REMARK 470     LYS C 166    CG   CD   CE   NZ                                   
REMARK 470     ASN C 167    CG   OD1  ND2                                       
REMARK 470     GLU C 169    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 184    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 186    CG   OD1  OD2                                       
REMARK 470     ASP C 214    CG   OD1  OD2                                       
REMARK 470     GLU C 224    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 243    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 271    CG   OD1  OD2                                       
REMARK 470     ASP C 276    CG   OD1  OD2                                       
REMARK 470     PHE C 298    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS C 300    CG   CD   CE   NZ                                   
REMARK 470     LYS C 325    CG   CD   CE   NZ                                   
REMARK 470     GLU C 326    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 340    CG   CD   CE   NZ                                   
REMARK 470     LYS C 362    CG   CD   CE   NZ                                   
REMARK 470     GLU C 365    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 368    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 369    CG   CD   CE   NZ                                   
REMARK 470     GLU C 375    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 383    CG   CD   CE   NZ                                   
REMARK 470     MET C 391    CG   SD   CE                                        
REMARK 470     GLU C 392    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 393    CG   CD   CE   NZ                                   
REMARK 470     ASP C 394    CG   OD1  OD2                                       
REMARK 470     ARG C 405    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP C 437    CG   OD1  OD2                                       
REMARK 470     LYS C 461    CG   CD   CE   NZ                                   
REMARK 470     GLU C 465    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 477    CG   OD1  OD2                                       
REMARK 470     GLU C 482    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 503    CG   OD1  OD2                                       
REMARK 470     GLU C 508    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 512    CG   CD   CE   NZ                                   
REMARK 470     LYS C 531    CG   CD   CE   NZ                                   
REMARK 470     THR C 532    OG1  CG2                                            
REMARK 470     GLU C 533    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 541    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 555    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 558    CG   CD   CE   NZ                                   
REMARK 470     LYS C 581    CG   CD   CE   NZ                                   
REMARK 470     LYS C 583    CG   CD   CE   NZ                                   
REMARK 470     GLU C 584    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 585    CG   OD1  OD2                                       
REMARK 470     LYS C 587    CG   CD   CE   NZ                                   
REMARK 470     GLN C 588    CG   CD   OE1  NE2                                  
REMARK 470     LYS C 665    CG   CD   CE   NZ                                   
REMARK 470     GLU C 667    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 672    CG   OD1  OD2                                       
REMARK 470     GLU C 679    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 713    CG   CD   OE1  OE2                                  
REMARK 470     MET C 715    CG   SD   CE                                        
REMARK 470     ASP C 716    CG   OD1  OD2                                       
REMARK 470     LYS C 718    CG   CD   CE   NZ                                   
REMARK 470     ASP C 722    CG   OD1  OD2                                       
REMARK 470     ARG C 745    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 746    CG   CD   CE   NZ                                   
REMARK 470     LYS C 749    CG   CD   CE   NZ                                   
REMARK 470     ARG C 752    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 754    CG   CD   OE1  OE2                                  
REMARK 470     TRP C 757    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP C 757    CZ3  CH2                                            
REMARK 470     ARG C 763    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP C 766    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP C 766    CZ3  CH2                                            
REMARK 470     LEU C 779    CG   CD1  CD2                                       
REMARK 470     LYS C 792    CG   CD   CE   NZ                                   
REMARK 470     GLU C 793    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 804    CG   CD   CE   NZ                                   
REMARK 470     GLU C 805    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 810    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 811    CG   CD   OE1  OE2                                  
REMARK 470     GLN C 817    CG   CD   OE1  NE2                                  
REMARK 470     GLN C 837    CG   CD   OE1  NE2                                  
REMARK 470     GLU C 859    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 863    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 877    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 878    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 901    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 910    CG   CD   OE1  OE2                                  
REMARK 470     MET C 927    CG   SD   CE                                        
REMARK 470     LYS C 935    CG   CD   CE   NZ                                   
REMARK 470     ASP C 948    CG   OD1  OD2                                       
REMARK 470     LEU C 989    CG   CD1  CD2                                       
REMARK 470     GLU C 990    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 991    CG   CD   CE   NZ                                   
REMARK 470     TYR C 992    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE C 993    CG1  CG2  CD1                                       
REMARK 470     SER C 994    OG                                                  
REMARK 470     GLU C 996    CG   CD   OE1  OE2                                  
REMARK 470     LEU C 997    CG   CD1  CD2                                       
REMARK 470     TYR C 998    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OE1  GLU A   466     CZ   TYR C   387              0.80            
REMARK 500   CD   GLU A   466     OH   TYR C   387              0.97            
REMARK 500   OE1  GLU A   466     OH   TYR C   387              1.21            
REMARK 500   CG   GLU A   466     OH   TYR C   387              1.24            
REMARK 500   CD   GLU A   466     CZ   TYR C   387              1.36            
REMARK 500   N2     G W    31     N    GLY A  1636              1.36            
REMARK 500   OE1  GLU A   466     CE2  TYR C   387              1.44            
REMARK 500   N3     A W    26     O    TYR A   667              1.66            
REMARK 500   CB   GLU A   466     OH   TYR C   387              1.68            
REMARK 500   CD2  LEU A   462     ND2  ASN C   403              1.77            
REMARK 500   OE2  GLU A   466     CE1  TYR C   387              1.85            
REMARK 500   C2     A W    26     O    TYR A   667              1.89            
REMARK 500   CD   GLU A   466     CE1  TYR C   387              1.90            
REMARK 500   N2     G W    31     CA   GLY A  1636              1.90            
REMARK 500   O    ALA A   459     CE1  PHE C   376              1.94            
REMARK 500   C    ALA A   459     CE1  PHE C   376              2.03            
REMARK 500   OE1  GLU A   466     CE1  TYR C   387              2.04            
REMARK 500   C5     A W    26     CD1  TYR A   671              2.10            
REMARK 500   OE2  GLU A   466     CZ   TYR C   387              2.15            
REMARK 500   O    ALA K    40     OG1  THR K    43              2.16            
REMARK 500   C8     A W    26     CE1  TYR A   671              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500      A V  17   C2' -  C3' -  O3' ANGL. DEV. =  13.3 DEGREES          
REMARK 500      A W  45   C2' -  C3' -  O3' ANGL. DEV. =  10.7 DEGREES          
REMARK 500    LEU J 613   CA  -  CB  -  CG  ANGL. DEV. =  16.9 DEGREES          
REMARK 500    LEU D 103   CA  -  CB  -  CG  ANGL. DEV. =  15.1 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER A 125       80.32     66.98                                   
REMARK 500    LYS A 166      -19.51    -48.65                                   
REMARK 500    ASN A 178       48.93    -86.91                                   
REMARK 500    PRO A 182      -34.02    -35.35                                   
REMARK 500    ILE A 199       73.45     35.94                                   
REMARK 500    ASP A 230      -70.49    -65.88                                   
REMARK 500    PRO A 247       51.71   -115.58                                   
REMARK 500    PRO A 248       87.08    -69.41                                   
REMARK 500    TYR A 251      -61.11   -127.08                                   
REMARK 500    GLU A 256       50.41   -104.71                                   
REMARK 500    PRO A 260       98.33    -49.10                                   
REMARK 500    ASP A 262       94.01     -5.00                                   
REMARK 500    ASP A 273       77.66   -103.89                                   
REMARK 500    LEU A 280      -79.19    -69.40                                   
REMARK 500    SER A 302      118.69   -161.03                                   
REMARK 500    THR A 316      -52.77    -26.17                                   
REMARK 500    ARG A 319       64.12   -106.24                                   
REMARK 500    THR A 323       51.83    -97.98                                   
REMARK 500    PHE A 331       22.50   -141.85                                   
REMARK 500    LEU A 355      -15.46     78.26                                   
REMARK 500    ARG A 358       88.38    -69.20                                   
REMARK 500    GLU A 360     -116.28    -81.93                                   
REMARK 500    TYR A 364       79.25     63.67                                   
REMARK 500    PHE A 375       61.76   -101.80                                   
REMARK 500    PHE A 387       53.89   -149.89                                   
REMARK 500    TYR A 403       39.86   -157.80                                   
REMARK 500    ASN A 413       67.35   -109.69                                   
REMARK 500    ASP A 418       30.49     75.21                                   
REMARK 500    PRO A 426     -179.80    -57.87                                   
REMARK 500    GLU A 464        0.42     80.70                                   
REMARK 500    LEU A 470     -142.57    -80.72                                   
REMARK 500    ARG A 495        8.89    -56.44                                   
REMARK 500    ALA A 496      -36.86     67.09                                   
REMARK 500    ASP A 498     -178.21    -64.24                                   
REMARK 500    VAL A 499       65.88     62.38                                   
REMARK 500    GLN A 508      106.75    -53.59                                   
REMARK 500    HIS A 509       95.56    -43.79                                   
REMARK 500    THR A 540     -147.69   -155.94                                   
REMARK 500    LEU A 551      -71.43    -70.99                                   
REMARK 500    ASN A 596       54.68    -91.76                                   
REMARK 500    PHE A 597       -5.08     32.96                                   
REMARK 500    ASN A 598       92.85    -60.26                                   
REMARK 500    LYS A 603     -176.58   -171.23                                   
REMARK 500    THR A 604       64.57     65.98                                   
REMARK 500    LEU A 615     -148.38     41.71                                   
REMARK 500    ASN A 692       52.24    -95.89                                   
REMARK 500    PHE A 703       80.75     36.78                                   
REMARK 500    PRO A 771       52.08    -95.46                                   
REMARK 500    ILE A 774       42.49     37.83                                   
REMARK 500    ASN A 796       64.77     93.31                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     489 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 LEU A  286     GLU A  287                 -149.97                    
REMARK 500 GLU A  467     LEU A  468                 -143.40                    
REMARK 500 PHE A  557     GLN A  558                 -148.92                    
REMARK 500 ASN A  974     TYR A  975                 -144.30                    
REMARK 500 SER A  979     PRO A  980                  -30.07                    
REMARK 500 SER A 1096     HIS A 1097                  144.00                    
REMARK 500 ILE A 1216     ARG A 1217                 -147.10                    
REMARK 500 VAL A 1279     SER A 1280                  149.69                    
REMARK 500 ASN A 1522     SER A 1523                 -148.74                    
REMARK 500 LEU J  201     SER J  202                  131.49                    
REMARK 500 GLN J  820     TYR J  821                 -149.69                    
REMARK 500 SER F  154     ASP F  155                  -40.49                    
REMARK 500 ILE B  423     PRO B  424                  131.53                    
REMARK 500 PRO B  458     GLN B  459                  130.81                    
REMARK 500 LEU k   84     THR k   85                 -146.11                    
REMARK 500 LEU C  607     GLN C  608                  148.66                    
REMARK 500 PRO C  958     ILE C  959                 -147.57                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8012   RELATED DB: EMDB                              
DBREF1 5GAN V    1   160  GB                   CP011083.1                       
DBREF2 5GAN V     807071957                      164495      164336             
DBREF1 5GAN W    1   112  GB                   CP011090.1                       
DBREF2 5GAN W     807071964                      348700      348811             
DBREF  5GAN A    1  2413  UNP    P33334   PRP8_YEAST       1   2413             
DBREF  5GAN H    1   465  UNP    P20053   PRP4_YEAST       1    465             
DBREF  5GAN J    1   899  UNP    P19735   PRP6_YEAST       1    899             
DBREF  5GAN D    1   143  UNP    Q06819   DIB1_YEAST       1    143             
DBREF  5GAN F    1   494  UNP    P49704   PRP31_YEAST      1    494             
DBREF  5GAN G    1   469  UNP    Q03338   PRP3_YEAST       1    469             
DBREF  5GAN B    1  2163  UNP    P32639   BRR2_YEAST       1   2163             
DBREF  5GAN x    1   218  PDB    5GAN     5GAN             1    218             
DBREF  5GAN k    1   196  UNP    P40018   RSMB_YEAST       1    196             
DBREF  5GAN l    1   146  UNP    Q02260   SMD1_YEAST       1    146             
DBREF  5GAN m    1   110  UNP    Q06217   SMD2_YEAST       1    110             
DBREF  5GAN n    1   101  UNP    P43321   SMD3_YEAST       1    101             
DBREF  5GAN p    1    94  UNP    Q12330   RUXE_YEAST       1     94             
DBREF  5GAN q    1    86  UNP    P54999   RUXF_YEAST       1     86             
DBREF  5GAN r    1    77  UNP    P40204   RUXG_YEAST       1     77             
DBREF  5GAN E    5   560  PDB    5GAN     5GAN             5    560             
DBREF  5GAN b    1   196  UNP    P40018   RSMB_YEAST       1    196             
DBREF  5GAN e    1    94  UNP    Q12330   RUXE_YEAST       1     94             
DBREF  5GAN f    1    86  UNP    P54999   RUXF_YEAST       1     86             
DBREF  5GAN g    1    77  UNP    P40204   RUXG_YEAST       1     77             
DBREF  5GAN d    1   101  UNP    P43321   SMD3_YEAST       1    101             
DBREF  5GAN h    1   146  UNP    Q02260   SMD1_YEAST       1    146             
DBREF  5GAN j    1   110  UNP    Q06217   SMD2_YEAST       1    110             
DBREF1 5GAN U    1   214  GB                   CP011085.1                       
DBREF2 5GAN U     807071959                      909079      908866             
DBREF  5GAN K    1   126  UNP    P39990   SNU13_YEAST      1    126             
DBREF  5GAN 2    1    95  UNP    P38203   LSM2_YEAST       1     95             
DBREF  5GAN 3    1    89  UNP    P57743   LSM3_YEAST       1     89             
DBREF  5GAN 4    1   187  UNP    P40070   LSM4_YEAST       1    187             
DBREF  5GAN 5    1    93  UNP    P40089   LSM5_YEAST       1     93             
DBREF  5GAN 6    1    86  UNP    A6ZYX7   LSM6_YEAS7       1     86             
DBREF  5GAN 7    1   115  UNP    P53905   LSM7_YEAST       1    115             
DBREF  5GAN 8    1   109  UNP    P47093   LSM8_YEAST       1    109             
DBREF  5GAN C    1  1008  UNP    P36048   SN114_YEAST      1   1008             
SEQADV 5GAN SER C  530  UNP  P36048    GLU   530 CONFLICT                       
SEQADV 5GAN LYS C  531  UNP  P36048    ASP   531 CONFLICT                       
SEQADV 5GAN THR C  532  UNP  P36048    ASP   532 CONFLICT                       
SEQRES   1 V  160    A   U   C   C   U   U   A   U   G   C   A   C   G          
SEQRES   2 V  160    G   G   A   A   A   U   A   C   G   C   A   U   A          
SEQRES   3 V  160    U   C   A   G   U   G   A   G   G   A   U   U   C          
SEQRES   4 V  160    G   U   C   C   G   A   G   A   U   U   G   U   G          
SEQRES   5 V  160    U   U   U   U   U   G   C   U   G   G   U   U   G          
SEQRES   6 V  160    A   A   A   U   U   U   A   A   U   U   A   U   A          
SEQRES   7 V  160    A   A   C   C   A   G   A   C   C   G   U   C   U          
SEQRES   8 V  160    C   C   U   C   A   U   G   G   U   C   A   A   U          
SEQRES   9 V  160    U   C   G   G   U   G   U   U   C   G   C   U   U          
SEQRES  10 V  160    U   U   G   A   A   U   A   C   U   U   C   A   A          
SEQRES  11 V  160    G   A   C   U   A   U   G   U   A   G   G   G   A          
SEQRES  12 V  160    A   U   U   U   U   U   G   G   A   A   U   A   C          
SEQRES  13 V  160    C   U   U   U                                              
SEQRES   1 W  112    G   U   U   C   G   C   G   A   A   G   U   A   A          
SEQRES   2 W  112    C   C   C   U   U   C   G   U   G   G   A   C   A          
SEQRES   3 W  112    U   U   U   G   G   U   C   A   A   U   U   U   G          
SEQRES   4 W  112    A   A   A   C   A   A   U   A   C   A   G   A   G          
SEQRES   5 W  112    A   U   G   A   U   C   A   G   C   A   G   U   U          
SEQRES   6 W  112    C   C   C   C   U   G   C   A   U   A   A   G   G          
SEQRES   7 W  112    A   U   G   A   A   C   C   G   U   U   U   U   A          
SEQRES   8 W  112    C   A   A   A   G   A   G   A   U   U   U   A   U          
SEQRES   9 W  112    U   U   C   G   U   U   U   U                              
SEQRES   1 A 2413  MET SER GLY LEU PRO PRO PRO PRO PRO GLY PHE GLU GLU          
SEQRES   2 A 2413  ASP SER ASP LEU ALA LEU PRO PRO PRO PRO PRO PRO PRO          
SEQRES   3 A 2413  PRO GLY TYR GLU ILE GLU GLU LEU ASP ASN PRO MET VAL          
SEQRES   4 A 2413  PRO SER SER VAL ASN GLU ASP THR PHE LEU PRO PRO PRO          
SEQRES   5 A 2413  PRO PRO PRO PRO SER ASN PHE GLU ILE ASN ALA GLU GLU          
SEQRES   6 A 2413  ILE VAL ASP PHE THR LEU PRO PRO PRO PRO PRO PRO PRO          
SEQRES   7 A 2413  GLY LEU ASP GLU LEU GLU THR LYS ALA GLU LYS LYS VAL          
SEQRES   8 A 2413  GLU LEU HIS GLY LYS ARG LYS LEU ASP ILE GLY LYS ASP          
SEQRES   9 A 2413  THR PHE VAL THR ARG LYS SER ARG LYS ARG ALA LYS LYS          
SEQRES  10 A 2413  MET THR LYS LYS ALA LYS ARG SER ASN LEU TYR THR PRO          
SEQRES  11 A 2413  LYS ALA GLU MET PRO PRO GLU HIS LEU ARG LYS ILE ILE          
SEQRES  12 A 2413  ASN THR HIS SER ASP MET ALA SER LYS MET TYR ASN THR          
SEQRES  13 A 2413  ASP LYS LYS ALA PHE LEU GLY ALA LEU LYS TYR LEU PRO          
SEQRES  14 A 2413  HIS ALA ILE LEU LYS LEU LEU GLU ASN MET PRO HIS PRO          
SEQRES  15 A 2413  TRP GLU GLN ALA LYS GLU VAL LYS VAL LEU TYR HIS THR          
SEQRES  16 A 2413  SER GLY ALA ILE THR PHE VAL ASN GLU THR PRO ARG VAL          
SEQRES  17 A 2413  ILE GLU PRO VAL TYR THR ALA GLN TRP SER ALA THR TRP          
SEQRES  18 A 2413  ILE ALA MET ARG ARG GLU LYS ARG ASP ARG THR HIS PHE          
SEQRES  19 A 2413  LYS ARG MET ARG PHE PRO PRO PHE ASP ASP ASP GLU PRO          
SEQRES  20 A 2413  PRO LEU SER TYR GLU GLN HIS ILE GLU ASN ILE GLU PRO          
SEQRES  21 A 2413  LEU ASP PRO ILE ASN LEU PRO LEU ASP SER GLN ASP ASP          
SEQRES  22 A 2413  GLU TYR VAL LYS ASP TRP LEU TYR ASP SER ARG PRO LEU          
SEQRES  23 A 2413  GLU GLU ASP SER LYS LYS VAL ASN GLY THR SER TYR LYS          
SEQRES  24 A 2413  LYS TRP SER PHE ASP LEU PRO GLU MET SER ASN LEU TYR          
SEQRES  25 A 2413  ARG LEU SER THR PRO LEU ARG ASP GLU VAL THR ASP LYS          
SEQRES  26 A 2413  ASN TYR TYR TYR LEU PHE ASP LYS LYS SER PHE PHE ASN          
SEQRES  27 A 2413  GLY LYS ALA LEU ASN ASN ALA ILE PRO GLY GLY PRO LYS          
SEQRES  28 A 2413  PHE GLU PRO LEU TYR PRO ARG GLU GLU GLU GLU ASP TYR          
SEQRES  29 A 2413  ASN GLU PHE ASN SER ILE ASP ARG VAL ILE PHE ARG VAL          
SEQRES  30 A 2413  PRO ILE ARG SER GLU TYR LYS VAL ALA PHE PRO HIS LEU          
SEQRES  31 A 2413  TYR ASN SER ARG PRO ARG SER VAL ARG ILE PRO TRP TYR          
SEQRES  32 A 2413  ASN ASN PRO VAL SER CYS ILE ILE GLN ASN ASP GLU GLU          
SEQRES  33 A 2413  TYR ASP THR PRO ALA LEU PHE PHE ASP PRO SER LEU ASN          
SEQRES  34 A 2413  PRO ILE PRO HIS PHE ILE ASP ASN ASN SER SER LEU ASN          
SEQRES  35 A 2413  VAL SER ASN THR LYS GLU ASN GLY ASP PHE THR LEU PRO          
SEQRES  36 A 2413  GLU ASP PHE ALA PRO LEU LEU ALA GLU GLU GLU GLU LEU          
SEQRES  37 A 2413  ILE LEU PRO ASN THR LYS ASP ALA MET SER LEU TYR HIS          
SEQRES  38 A 2413  SER PRO PHE PRO PHE ASN ARG THR LYS GLY LYS MET VAL          
SEQRES  39 A 2413  ARG ALA GLN ASP VAL ALA LEU ALA LYS LYS TRP PHE LEU          
SEQRES  40 A 2413  GLN HIS PRO ASP GLU GLU TYR PRO VAL LYS VAL LYS VAL          
SEQRES  41 A 2413  SER TYR GLN LYS LEU LEU LYS ASN TYR VAL LEU ASN GLU          
SEQRES  42 A 2413  LEU HIS PRO THR LEU PRO THR ASN HIS ASN LYS THR LYS          
SEQRES  43 A 2413  LEU LEU LYS SER LEU LYS ASN THR LYS TYR PHE GLN GLN          
SEQRES  44 A 2413  THR THR ILE ASP TRP VAL GLU ALA GLY LEU GLN LEU CYS          
SEQRES  45 A 2413  ARG GLN GLY HIS ASN MET LEU ASN LEU LEU ILE HIS ARG          
SEQRES  46 A 2413  LYS GLY LEU THR TYR LEU HIS LEU ASP TYR ASN PHE ASN          
SEQRES  47 A 2413  LEU LYS PRO THR LYS THR LEU THR THR LYS GLU ARG LYS          
SEQRES  48 A 2413  LYS SER ARG LEU GLY ASN SER PHE HIS LEU MET ARG GLU          
SEQRES  49 A 2413  LEU LEU LYS MET MET LYS LEU ILE VAL ASP THR HIS VAL          
SEQRES  50 A 2413  GLN PHE ARG LEU GLY ASN VAL ASP ALA PHE GLN LEU ALA          
SEQRES  51 A 2413  ASP GLY ILE HIS TYR ILE LEU ASN HIS ILE GLY GLN LEU          
SEQRES  52 A 2413  THR GLY ILE TYR ARG TYR LYS TYR LYS VAL MET HIS GLN          
SEQRES  53 A 2413  ILE ARG ALA CYS LYS ASP LEU LYS HIS ILE ILE TYR TYR          
SEQRES  54 A 2413  LYS PHE ASN LYS ASN LEU GLY LYS GLY PRO GLY CYS GLY          
SEQRES  55 A 2413  PHE TRP GLN PRO ALA TRP ARG VAL TRP LEU ASN PHE LEU          
SEQRES  56 A 2413  ARG GLY THR ILE PRO LEU LEU GLU ARG TYR ILE GLY ASN          
SEQRES  57 A 2413  LEU ILE THR ARG GLN PHE GLU GLY ARG SER ASN GLU ILE          
SEQRES  58 A 2413  VAL LYS THR THR THR LYS GLN ARG LEU ASP ALA TYR TYR          
SEQRES  59 A 2413  ASP LEU GLU LEU ARG ASN SER VAL MET ASP ASP ILE LEU          
SEQRES  60 A 2413  GLU MET MET PRO GLU SER ILE ARG GLN LYS LYS ALA ARG          
SEQRES  61 A 2413  THR ILE LEU GLN HIS LEU SER GLU ALA TRP ARG CYS TRP          
SEQRES  62 A 2413  LYS ALA ASN ILE PRO TRP ASP VAL PRO GLY MET PRO ALA          
SEQRES  63 A 2413  PRO ILE LYS LYS ILE ILE GLU ARG TYR ILE LYS SER LYS          
SEQRES  64 A 2413  ALA ASP ALA TRP VAL SER ALA ALA HIS TYR ASN ARG GLU          
SEQRES  65 A 2413  ARG ILE LYS ARG GLY ALA HIS VAL GLU LYS THR MET VAL          
SEQRES  66 A 2413  LYS LYS ASN LEU GLY ARG LEU THR ARG LEU TRP ILE LYS          
SEQRES  67 A 2413  ASN GLU GLN GLU ARG GLN ARG GLN ILE GLN LYS ASN GLY          
SEQRES  68 A 2413  PRO GLU ILE THR PRO GLU GLU ALA THR THR ILE PHE SER          
SEQRES  69 A 2413  VAL MET VAL GLU TRP LEU GLU SER ARG SER PHE SER PRO          
SEQRES  70 A 2413  ILE PRO PHE PRO PRO LEU THR TYR LYS ASN ASP THR LYS          
SEQRES  71 A 2413  ILE LEU VAL LEU ALA LEU GLU ASP LEU LYS ASP VAL TYR          
SEQRES  72 A 2413  ALA SER LYS VAL ARG LEU ASN ALA SER GLU ARG GLU GLU          
SEQRES  73 A 2413  LEU ALA LEU ILE GLU GLU ALA TYR ASP ASN PRO HIS ASP          
SEQRES  74 A 2413  THR LEU ASN ARG ILE LYS LYS TYR LEU LEU THR GLN ARG          
SEQRES  75 A 2413  VAL PHE LYS PRO VAL ASP ILE THR MET MET GLU ASN TYR          
SEQRES  76 A 2413  GLN ASN ILE SER PRO VAL TYR SER VAL ASP PRO LEU GLU          
SEQRES  77 A 2413  LYS ILE THR ASP ALA TYR LEU ASP GLN TYR LEU TRP TYR          
SEQRES  78 A 2413  GLU ALA ASP GLN ARG LYS LEU PHE PRO ASN TRP ILE LYS          
SEQRES  79 A 2413  PRO SER ASP SER GLU ILE PRO PRO LEU LEU VAL TYR LYS          
SEQRES  80 A 2413  TRP THR GLN GLY ILE ASN ASN LEU SER GLU ILE TRP ASP          
SEQRES  81 A 2413  VAL SER ARG GLY GLN SER ALA VAL LEU LEU GLU THR THR          
SEQRES  82 A 2413  LEU GLY GLU MET ALA GLU LYS ILE ASP PHE THR LEU LEU          
SEQRES  83 A 2413  ASN ARG LEU LEU ARG LEU ILE VAL ASP PRO ASN ILE ALA          
SEQRES  84 A 2413  ASP TYR ILE THR ALA LYS ASN ASN VAL VAL ILE ASN PHE          
SEQRES  85 A 2413  LYS ASP MET SER HIS VAL ASN LYS TYR GLY LEU ILE ARG          
SEQRES  86 A 2413  GLY LEU LYS PHE ALA SER PHE ILE PHE GLN TYR TYR GLY          
SEQRES  87 A 2413  LEU VAL ILE ASP LEU LEU LEU LEU GLY GLN GLU ARG ALA          
SEQRES  88 A 2413  THR ASP LEU ALA GLY PRO ALA ASN ASN PRO ASN GLU PHE          
SEQRES  89 A 2413  MET GLN PHE LYS SER LYS GLU VAL GLU LYS ALA HIS PRO          
SEQRES  90 A 2413  ILE ARG LEU TYR THR ARG TYR LEU ASP ARG ILE TYR MET          
SEQRES  91 A 2413  LEU PHE HIS PHE GLU GLU ASP GLU GLY GLU GLU LEU THR          
SEQRES  92 A 2413  ASP GLU TYR LEU ALA GLU ASN PRO ASP PRO ASN PHE GLU          
SEQRES  93 A 2413  ASN SER ILE GLY TYR ASN ASN ARG LYS CYS TRP PRO LYS          
SEQRES  94 A 2413  ASP SER ARG MET ARG LEU ILE ARG GLN ASP VAL ASN LEU          
SEQRES  95 A 2413  GLY ARG ALA VAL PHE TRP GLU ILE GLN SER ARG VAL PRO          
SEQRES  96 A 2413  THR SER LEU THR SER ILE LYS TRP GLU ASN ALA PHE VAL          
SEQRES  97 A 2413  SER VAL TYR SER LYS ASN ASN PRO ASN LEU LEU PHE SER          
SEQRES  98 A 2413  MET CYS GLY PHE GLU VAL ARG ILE LEU PRO ARG GLN ARG          
SEQRES  99 A 2413  MET GLU GLU VAL VAL SER ASN ASP GLU GLY VAL TRP ASP          
SEQRES 100 A 2413  LEU VAL ASP GLU ARG THR LYS GLN ARG THR ALA LYS ALA          
SEQRES 101 A 2413  TYR LEU LYS VAL SER GLU GLU GLU ILE LYS LYS PHE ASP          
SEQRES 102 A 2413  SER ARG ILE ARG GLY ILE LEU MET ALA SER GLY SER THR          
SEQRES 103 A 2413  THR PHE THR LYS VAL ALA ALA LYS TRP ASN THR SER LEU          
SEQRES 104 A 2413  ILE SER LEU PHE THR TYR PHE ARG GLU ALA ILE VAL ALA          
SEQRES 105 A 2413  THR GLU PRO LEU LEU ASP ILE LEU VAL LYS GLY GLU THR          
SEQRES 106 A 2413  ARG ILE GLN ASN ARG VAL LYS LEU GLY LEU ASN SER LYS          
SEQRES 107 A 2413  MET PRO THR ARG PHE PRO PRO ALA VAL PHE TYR THR PRO          
SEQRES 108 A 2413  LYS GLU LEU GLY GLY LEU GLY MET ILE SER ALA SER HIS          
SEQRES 109 A 2413  ILE LEU ILE PRO ALA SER ASP LEU SER TRP SER LYS GLN          
SEQRES 110 A 2413  THR ASP THR GLY ILE THR HIS PHE ARG ALA GLY MET THR          
SEQRES 111 A 2413  HIS GLU ASP GLU LYS LEU ILE PRO THR ILE PHE ARG TYR          
SEQRES 112 A 2413  ILE THR THR TRP GLU ASN GLU PHE LEU ASP SER GLN ARG          
SEQRES 113 A 2413  VAL TRP ALA GLU TYR ALA THR LYS ARG GLN GLU ALA ILE          
SEQRES 114 A 2413  GLN GLN ASN ARG ARG LEU ALA PHE GLU GLU LEU GLU GLY          
SEQRES 115 A 2413  SER TRP ASP ARG GLY ILE PRO ARG ILE SER THR LEU PHE          
SEQRES 116 A 2413  GLN ARG ASP ARG HIS THR LEU ALA TYR ASP ARG GLY HIS          
SEQRES 117 A 2413  ARG ILE ARG ARG GLU PHE LYS GLN TYR SER LEU GLU ARG          
SEQRES 118 A 2413  ASN SER PRO PHE TRP TRP THR ASN SER HIS HIS ASP GLY          
SEQRES 119 A 2413  LYS LEU TRP ASN LEU ASN ALA TYR ARG THR ASP VAL ILE          
SEQRES 120 A 2413  GLN ALA LEU GLY GLY ILE GLU THR ILE LEU GLU HIS THR          
SEQRES 121 A 2413  LEU PHE LYS GLY THR GLY PHE ASN SER TRP GLU GLY LEU          
SEQRES 122 A 2413  PHE TRP GLU LYS ALA SER GLY PHE GLU ASP SER MET GLN          
SEQRES 123 A 2413  PHE LYS LYS LEU THR HIS ALA GLN ARG THR GLY LEU SER          
SEQRES 124 A 2413  GLN ILE PRO ASN ARG ARG PHE THR LEU TRP TRP SER PRO          
SEQRES 125 A 2413  THR ILE ASN ARG ALA ASN VAL TYR VAL GLY PHE LEU VAL          
SEQRES 126 A 2413  GLN LEU ASP LEU THR GLY ILE PHE LEU HIS GLY LYS ILE          
SEQRES 127 A 2413  PRO THR LEU LYS ILE SER LEU ILE GLN ILE PHE ARG ALA          
SEQRES 128 A 2413  HIS LEU TRP GLN LYS ILE HIS GLU SER ILE VAL PHE ASP          
SEQRES 129 A 2413  ILE CYS GLN ILE LEU ASP GLY GLU LEU ASP VAL LEU GLN          
SEQRES 130 A 2413  ILE GLU SER VAL THR LYS GLU THR VAL HIS PRO ARG LYS          
SEQRES 131 A 2413  SER TYR LYS MET ASN SER SER ALA ALA ASP ILE THR MET          
SEQRES 132 A 2413  GLU SER VAL HIS GLU TRP GLU VAL SER LYS PRO SER LEU          
SEQRES 133 A 2413  LEU HIS GLU THR ASN ASP SER PHE LYS GLY LEU ILE THR          
SEQRES 134 A 2413  ASN LYS MET TRP PHE ASP VAL GLN LEU ARG TYR GLY ASP          
SEQRES 135 A 2413  TYR ASP SER HIS ASP ILE SER ARG TYR VAL ARG ALA LYS          
SEQRES 136 A 2413  PHE LEU ASP TYR THR THR ASP ASN VAL SER MET TYR PRO          
SEQRES 137 A 2413  SER PRO THR GLY VAL MET ILE GLY ILE ASP LEU ALA TYR          
SEQRES 138 A 2413  ASN MET TYR ASP ALA TYR GLY ASN TRP PHE ASN GLY LEU          
SEQRES 139 A 2413  LYS PRO LEU ILE GLN ASN SER MET ARG THR ILE MET LYS          
SEQRES 140 A 2413  ALA ASN PRO ALA LEU TYR VAL LEU ARG GLU ARG ILE ARG          
SEQRES 141 A 2413  LYS GLY LEU GLN ILE TYR GLN SER SER VAL GLN GLU PRO          
SEQRES 142 A 2413  PHE LEU ASN SER SER ASN TYR ALA GLU LEU PHE ASN ASN          
SEQRES 143 A 2413  ASP ILE LYS LEU PHE VAL ASP ASP THR ASN VAL TYR ARG          
SEQRES 144 A 2413  VAL THR VAL HIS LYS THR PHE GLU GLY ASN VAL ALA THR          
SEQRES 145 A 2413  LYS ALA ILE ASN GLY CYS ILE PHE THR LEU ASN PRO LYS          
SEQRES 146 A 2413  THR GLY HIS LEU PHE LEU LYS ILE ILE HIS THR SER VAL          
SEQRES 147 A 2413  TRP ALA GLY GLN LYS ARG LEU SER GLN LEU ALA LYS TRP          
SEQRES 148 A 2413  LYS THR ALA GLU GLU VAL SER ALA LEU VAL ARG SER LEU          
SEQRES 149 A 2413  PRO LYS GLU GLU GLN PRO LYS GLN ILE ILE VAL THR ARG          
SEQRES 150 A 2413  LYS ALA MET LEU ASP PRO LEU GLU VAL HIS MET LEU ASP          
SEQRES 151 A 2413  PHE PRO ASN ILE ALA ILE ARG PRO THR GLU LEU ARG LEU          
SEQRES 152 A 2413  PRO PHE SER ALA ALA MET SER ILE ASP LYS LEU SER ASP          
SEQRES 153 A 2413  VAL VAL MET LYS ALA THR GLU PRO GLN MET VAL LEU PHE          
SEQRES 154 A 2413  ASN ILE TYR ASP ASP TRP LEU ASP ARG ILE SER SER TYR          
SEQRES 155 A 2413  THR ALA PHE SER ARG LEU THR LEU LEU LEU ARG ALA LEU          
SEQRES 156 A 2413  LYS THR ASN GLU GLU SER ALA LYS MET ILE LEU LEU SER          
SEQRES 157 A 2413  ASP PRO THR ILE THR ILE LYS SER TYR HIS LEU TRP PRO          
SEQRES 158 A 2413  SER PHE THR ASP GLU GLN TRP ILE THR ILE GLU SER GLN          
SEQRES 159 A 2413  MET ARG ASP LEU ILE LEU THR GLU TYR GLY ARG LYS TYR          
SEQRES 160 A 2413  ASN VAL ASN ILE SER ALA LEU THR GLN THR GLU ILE LYS          
SEQRES 161 A 2413  ASP ILE ILE LEU GLY GLN ASN ILE LYS ALA PRO SER VAL          
SEQRES 162 A 2413  LYS ARG GLN LYS MET ALA GLU LEU GLU ALA ALA ARG SER          
SEQRES 163 A 2413  GLU LYS GLN ASN ASP GLU GLU ALA ALA GLY ALA SER THR          
SEQRES 164 A 2413  VAL MET LYS THR LYS THR ILE ASN ALA GLN GLY GLU GLU          
SEQRES 165 A 2413  ILE VAL VAL VAL ALA SER ALA ASP TYR GLU SER GLN THR          
SEQRES 166 A 2413  PHE SER SER LYS ASN GLU TRP ARG LYS SER ALA ILE ALA          
SEQRES 167 A 2413  ASN THR LEU LEU TYR LEU ARG LEU LYS ASN ILE TYR VAL          
SEQRES 168 A 2413  SER ALA ASP ASP PHE VAL GLU GLU GLN ASN VAL TYR VAL          
SEQRES 169 A 2413  LEU PRO LYS ASN LEU LEU LYS LYS PHE ILE GLU ILE SER          
SEQRES 170 A 2413  ASP VAL LYS ILE GLN VAL ALA ALA PHE ILE TYR GLY MET          
SEQRES 171 A 2413  SER ALA LYS ASP HIS PRO LYS VAL LYS GLU ILE LYS THR          
SEQRES 172 A 2413  VAL VAL LEU VAL PRO GLN LEU GLY HIS VAL GLY SER VAL          
SEQRES 173 A 2413  GLN ILE SER ASN ILE PRO ASP ILE GLY ASP LEU PRO ASP          
SEQRES 174 A 2413  THR GLU GLY LEU GLU LEU LEU GLY TRP ILE HIS THR GLN          
SEQRES 175 A 2413  THR GLU GLU LEU LYS PHE MET ALA ALA SER GLU VAL ALA          
SEQRES 176 A 2413  THR HIS SER LYS LEU PHE ALA ASP LYS LYS ARG ASP CYS          
SEQRES 177 A 2413  ILE ASP ILE SER ILE PHE SER THR PRO GLY SER VAL SER          
SEQRES 178 A 2413  LEU SER ALA TYR ASN LEU THR ASP GLU GLY TYR GLN TRP          
SEQRES 179 A 2413  GLY GLU GLU ASN LYS ASP ILE MET ASN VAL LEU SER GLU          
SEQRES 180 A 2413  GLY PHE GLU PRO THR PHE SER THR HIS ALA GLN LEU LEU          
SEQRES 181 A 2413  LEU SER ASP ARG ILE THR GLY ASN PHE ILE ILE PRO SER          
SEQRES 182 A 2413  GLY ASN VAL TRP ASN TYR THR PHE MET GLY THR ALA PHE          
SEQRES 183 A 2413  ASN GLN GLU GLY ASP TYR ASN PHE LYS TYR GLY ILE PRO          
SEQRES 184 A 2413  LEU GLU PHE TYR ASN GLU MET HIS ARG PRO VAL HIS PHE          
SEQRES 185 A 2413  LEU GLN PHE SER GLU LEU ALA GLY ASP GLU GLU LEU GLU          
SEQRES 186 A 2413  ALA GLU GLN ILE ASP VAL PHE SER                              
SEQRES   1 H  465  MET SER LYS TYR ILE ALA LEU GLU ASN LEU PRO VAL ASP          
SEQRES   2 H  465  LEU GLN HIS LYS GLY ALA THR GLN ASN GLU SER THR ALA          
SEQRES   3 H  465  ASP ILE LEU LYS GLN LEU PRO HIS GLU ARG LEU GLN ALA          
SEQRES   4 H  465  VAL LEU GLU LYS ILE PRO GLU GLU ASP LEU GLU VAL ARG          
SEQRES   5 H  465  ARG LEU LEU SER ILE LEU LYS LYS PRO GLU VAL VAL GLU          
SEQRES   6 H  465  ASN GLU ASP VAL GLN GLN ARG ARG ILE ARG LEU ALA GLU          
SEQRES   7 H  465  ILE LEU MET VAL ASP GLU ILE ASP LEU GLU ASN ILE ASN          
SEQRES   8 H  465  ASN MET GLU ASN ILE ASN GLY GLU GLU VAL ASP GLU GLU          
SEQRES   9 H  465  ASP ASP GLU ASP PHE PHE THR PRO ALA THR SER GLU LEU          
SEQRES  10 H  465  ILE PHE ALA ARG ARG PHE LEU ILE ASN TYR SER LEU GLU          
SEQRES  11 H  465  ARG SER ARG LYS ARG LEU GLN LYS GLU MET GLU ARG HIS          
SEQRES  12 H  465  GLN LYS PHE ASN THR ARG GLN GLU LEU LEU SER ARG ARG          
SEQRES  13 H  465  THR GLU LEU GLN ARG MET ALA ASN LEU GLU LEU ALA GLY          
SEQRES  14 H  465  SER GLN LEU VAL SER THR LYS PRO ILE SER ALA VAL SER          
SEQRES  15 H  465  LEU SER THR ASP ASP MET VAL VAL ALA THR GLY SER TRP          
SEQRES  16 H  465  ALA GLY ASP LEU GLN VAL LEU ASN SER GLN THR LEU GLN          
SEQRES  17 H  465  PRO LEU THR GLN LYS LEU ASP SER HIS VAL GLY LYS ILE          
SEQRES  18 H  465  GLY ALA ILE ASP TRP HIS PRO ASP SER ASN ASN GLN MET          
SEQRES  19 H  465  ILE SER CYS ALA GLU ASP GLY LEU ILE LYS ASN PHE GLN          
SEQRES  20 H  465  TYR SER ASN GLU GLU GLY GLY LEU ARG LEU LEU GLY ASP          
SEQRES  21 H  465  LEU VAL GLY HIS GLU ARG ARG ILE SER ASP VAL LYS TYR          
SEQRES  22 H  465  HIS PRO SER GLY LYS PHE ILE GLY SER ALA SER HIS ASP          
SEQRES  23 H  465  MET THR TRP ARG LEU TRP ASP ALA SER THR HIS GLN GLU          
SEQRES  24 H  465  LEU LEU LEU GLN GLU GLY HIS ASP LYS GLY VAL PHE SER          
SEQRES  25 H  465  LEU SER PHE GLN CYS ASP GLY SER LEU VAL CYS SER GLY          
SEQRES  26 H  465  GLY MET ASP SER LEU SER MET LEU TRP ASP ILE ARG SER          
SEQRES  27 H  465  GLY SER LYS VAL MET THR LEU ALA GLY HIS SER LYS PRO          
SEQRES  28 H  465  ILE TYR THR VAL ALA TRP SER PRO ASN GLY TYR GLN VAL          
SEQRES  29 H  465  ALA THR GLY GLY GLY ASP GLY ILE ILE ASN VAL TRP ASP          
SEQRES  30 H  465  ILE ARG LYS ARG ASP GLU GLY GLN LEU ASN GLN ILE LEU          
SEQRES  31 H  465  ALA HIS ARG ASN ILE VAL THR GLN VAL ARG PHE SER LYS          
SEQRES  32 H  465  GLU ASP GLY GLY LYS LYS LEU VAL SER CYS GLY TYR ASP          
SEQRES  33 H  465  ASN LEU ILE ASN VAL TYR SER SER ASP THR TRP LEU LYS          
SEQRES  34 H  465  MET GLY SER LEU ALA GLY HIS THR ASP LYS ILE ILE SER          
SEQRES  35 H  465  LEU ASP ILE SER ASN ASN SER HIS PHE LEU VAL SER GLY          
SEQRES  36 H  465  GLY TRP ASP ARG SER ILE LYS LEU TRP ASN                      
SEQRES   1 J  899  MET GLU ARG PRO SER PHE LEU ASP GLN GLU PRO PRO ALA          
SEQRES   2 J  899  GLY TYR VAL PRO GLY ILE GLY ARG GLY ALA THR GLY PHE          
SEQRES   3 J  899  SER THR LYS GLU LYS GLN VAL VAL SER ASN ASP ASP LYS          
SEQRES   4 J  899  GLY ARG ARG ILE PRO LYS ARG TYR ARG GLU ASN LEU ASN          
SEQRES   5 J  899  ASN HIS LEU GLN SER GLN PRO LYS ASP ASP GLU ASP ASP          
SEQRES   6 J  899  GLU ALA ALA ASN VAL PHE LYS THR LEU GLU LEU LYS LEU          
SEQRES   7 J  899  ALA GLN LYS LYS LYS LYS ARG ALA ASN GLU LYS ASP ASP          
SEQRES   8 J  899  ASP ASN SER VAL ASP SER SER ASN VAL LYS ARG GLN PHE          
SEQRES   9 J  899  ALA ASP LEU LYS GLU SER LEU ALA ALA VAL THR GLU SER          
SEQRES  10 J  899  GLU TRP MET ASP ILE PRO ASP ALA THR ASP PHE THR ARG          
SEQRES  11 J  899  ARG ASN LYS ARG ASN ARG ILE GLN GLU GLN LEU ASN ARG          
SEQRES  12 J  899  LYS THR TYR ALA ALA PRO ASP SER LEU ILE PRO GLY ASN          
SEQRES  13 J  899  VAL ASP LEU ASN LYS LEU THR GLU GLU ARG GLU LYS LEU          
SEQRES  14 J  899  LEU GLN SER GLN ILE ASP GLU ASN LEU ALA GLN LEU THR          
SEQRES  15 J  899  LYS ASN ALA SER ASN PRO ILE GLN VAL ASN LYS PRO ASN          
SEQRES  16 J  899  ALA ALA THR ASP ALA LEU SER TYR LEU LYS ASP LEU GLU          
SEQRES  17 J  899  ASN ASP ARG VAL ASN SER LEU SER ASP ALA THR LEU GLU          
SEQRES  18 J  899  ASP LEU GLN LYS MET ARG THR ILE LEU LYS SER TYR ARG          
SEQRES  19 J  899  LYS ALA ASP PRO THR ASN PRO GLN GLY TRP ILE ALA SER          
SEQRES  20 J  899  ALA ARG LEU GLU GLU LYS ALA ARG LYS PHE SER VAL ALA          
SEQRES  21 J  899  LYS LYS ILE ILE GLU ASN GLY CYS GLN GLU CYS PRO ARG          
SEQRES  22 J  899  SER SER ASP ILE TRP LEU GLU ASN ILE ARG LEU HIS GLU          
SEQRES  23 J  899  SER ASP VAL HIS TYR CYS LYS THR LEU VAL ALA THR ALA          
SEQRES  24 J  899  ILE ASN PHE ASN PRO THR SER PRO LEU LEU TRP PHE LYS          
SEQRES  25 J  899  ALA ILE ASP LEU GLU SER THR THR VAL ASN LYS TYR ARG          
SEQRES  26 J  899  VAL VAL ARG LYS ALA LEU GLN GLU ILE PRO ARG ASP GLU          
SEQRES  27 J  899  GLY LEU TRP LYS LEU ALA VAL SER PHE GLU ALA ASP LYS          
SEQRES  28 J  899  ALA GLN VAL ILE LYS MET LEU GLU LYS ALA THR GLN PHE          
SEQRES  29 J  899  ILE PRO GLN SER MET ASP LEU LEU THR ALA TYR THR ASN          
SEQRES  30 J  899  LEU GLN SER TYR HIS ASN ALA LYS MET THR LEU ASN SER          
SEQRES  31 J  899  PHE ARG LYS ILE LEU PRO GLN GLU PRO GLU ILE TRP ILE          
SEQRES  32 J  899  ILE SER THR LEU LEU GLU GLU ARG ASN ASN PRO ASP ILE          
SEQRES  33 J  899  PRO VAL ASP LYS LEU VAL SER LEU LEU LYS GLU GLY LEU          
SEQRES  34 J  899  LEU GLU LEU SER LYS ASN GLY TYR LYS ALA THR LEU SER          
SEQRES  35 J  899  ALA TRP LEU LYS ARG ALA GLU ALA LEU ASN ASP ALA PRO          
SEQRES  36 J  899  ASN SER ASN LEU THR CYS GLN ALA ILE VAL TYR ALA ILE          
SEQRES  37 J  899  LEU GLU TRP LEU ARG GLU SER GLY GLU TYR GLU SER GLU          
SEQRES  38 J  899  LEU ASN ASN VAL ASP GLN ILE LEU GLU LYS MET PRO HIS          
SEQRES  39 J  899  SER LYS VAL GLN ILE ALA VAL LEU LYS LYS LEU ILE GLN          
SEQRES  40 J  899  TRP ASP PRO CYS ASP THR VAL LEU TRP SER ARG LEU LYS          
SEQRES  41 J  899  MET ALA THR GLU SER TYR HIS LYS ILE GLU GLU LEU LEU          
SEQRES  42 J  899  ALA PHE PHE GLN GLU LEU LEU PHE GLN THR LYS ASN SER          
SEQRES  43 J  899  ASP ASP ILE ARG ALA ASN MET ARG GLU LYS SER PRO GLY          
SEQRES  44 J  899  LEU LEU MET MET TYR VAL SER GLU TYR TRP LYS ALA GLN          
SEQRES  45 J  899  LYS GLY ASP THR ARG GLN THR LEU VAL LEU ILE ASP GLN          
SEQRES  46 J  899  ILE ILE ASP PHE ALA PRO HIS ASN LEU ASP LEU ARG PHE          
SEQRES  47 J  899  PHE LYS ILE LYS LEU LEU GLY ARG SER LEU GLN LEU ASP          
SEQRES  48 J  899  GLU LEU ARG ASP PHE PHE GLN GLN THR PHE SER SER LEU          
SEQRES  49 J  899  GLU ASP PHE LYS ILE SER GLY THR GLU ARG LEU TYR TYR          
SEQRES  50 J  899  LYS TYR VAL ASN PHE LEU ARG TYR GLN ASP LEU ASN GLU          
SEQRES  51 J  899  GLU ALA ILE LYS PHE LEU ASN GLU ARG CYS LEU LYS SER          
SEQRES  52 J  899  PHE PRO ILE CYS HIS LYS PHE PHE LEU GLN LEU GLY GLN          
SEQRES  53 J  899  ILE TYR HIS SER MET GLY ASN ILE GLU MET SER ARG GLU          
SEQRES  54 J  899  THR TYR LEU SER GLY THR ARG LEU VAL PRO ASN CYS PRO          
SEQRES  55 J  899  LEU LEU TRP VAL SER LEU SER LYS ILE ASP GLU ILE ASP          
SEQRES  56 J  899  LEU LYS ASN PRO VAL ARG ALA ARG SER ILE LEU ASP ARG          
SEQRES  57 J  899  GLY LEU LEU LYS ASN PRO ASP ASP VAL LEU PHE TYR ILE          
SEQRES  58 J  899  ALA LYS ILE GLN MET GLU ILE ARG LEU GLY ASN LEU ASP          
SEQRES  59 J  899  GLN ALA GLU LEU LEU VAL THR GLN ALA LEU GLN LYS PHE          
SEQRES  60 J  899  PRO SER ASN ALA LEU LEU TRP VAL GLU GLN ILE LYS LEU          
SEQRES  61 J  899  PHE LYS HIS GLY ASN LYS SER SER LEU LYS LYS THR ILE          
SEQRES  62 J  899  PHE GLN ASP ALA LEU ARG ARG THR GLN ASN ASP HIS ARG          
SEQRES  63 J  899  VAL LEU LEU GLU ILE GLY VAL SER PHE TYR ALA GLU ALA          
SEQRES  64 J  899  GLN TYR GLU THR SER LEU LYS TRP LEU GLU ARG ALA LEU          
SEQRES  65 J  899  LYS LYS CYS SER ARG TYR GLY ASP THR TRP VAL TRP LEU          
SEQRES  66 J  899  PHE ARG THR TYR ALA ARG LEU GLY LYS ASP THR VAL ASP          
SEQRES  67 J  899  LEU TYR ASN MET PHE ASP GLN CYS GLU PRO THR TYR GLY          
SEQRES  68 J  899  PRO GLU TRP ILE ALA ALA SER LYS ASN VAL LYS MET GLN          
SEQRES  69 J  899  TYR CYS THR PRO ARG GLU ILE LEU LEU ARG LEU MET ASN          
SEQRES  70 J  899  ASP LYS                                                      
SEQRES   1 D  143  MET ALA SER VAL LEU LEU PRO GLN LEU ARG THR GLY TRP          
SEQRES   2 D  143  HIS VAL ASP GLN ALA ILE VAL THR GLU THR LYS ARG LEU          
SEQRES   3 D  143  VAL VAL ILE ARG PHE GLY ARG LYS ASN ASP ARG GLN CYS          
SEQRES   4 D  143  MET ILE MET ASP GLU LEU LEU SER SER ILE ALA GLU ARG          
SEQRES   5 D  143  VAL ARG ASN PHE ALA VAL ILE TYR LEU CYS ASP ILE ASP          
SEQRES   6 D  143  GLU VAL SER ASP PHE ASP GLU MET TYR GLU LEU THR ASP          
SEQRES   7 D  143  PRO MET THR VAL MET PHE PHE TYR HIS ASN LYS HIS MET          
SEQRES   8 D  143  MET CYS ASP PHE GLY THR GLY ASN ASN ASN LYS LEU ASN          
SEQRES   9 D  143  PHE ILE VAL ASP ASP LYS GLN GLU MET ILE ASP ILE LEU          
SEQRES  10 D  143  GLU THR ILE PHE ARG GLY ALA ARG LYS ASN LYS GLY LEU          
SEQRES  11 D  143  VAL VAL SER PRO TYR ASP TYR ASN HIS LYS ARG VAL SER          
SEQRES   1 F  494  MET SER SER GLU GLU ASP TYR PHE ASP GLU LEU GLU TYR          
SEQRES   2 F  494  ASP LEU ALA ASP GLU VAL ASN GLU GLU LYS GLU ASP ILE          
SEQRES   3 F  494  GLN THR LYS LYS LEU THR THR VAL ASN CYS GLN THR GLU          
SEQRES   4 F  494  LYS PHE ASN PRO PHE GLU ILE LEU PRO GLU SER ILE GLU          
SEQRES   5 F  494  LEU PHE ARG THR LEU ALA LEU ILE SER PRO ASP ARG LEU          
SEQRES   6 F  494  SER LEU SER GLU THR ALA GLN ILE LEU PRO LYS ILE VAL          
SEQRES   7 F  494  ASP LEU LYS ARG ILE LEU GLN GLN GLN GLU ILE ASP PHE          
SEQRES   8 F  494  ILE LYS LEU LEU PRO PHE PHE ASN GLU ILE ILE PRO LEU          
SEQRES   9 F  494  ILE LYS SER ASN ILE LYS LEU MET HIS ASN PHE LEU ILE          
SEQRES  10 F  494  SER LEU TYR SER ARG ARG PHE PRO GLU LEU SER SER LEU          
SEQRES  11 F  494  ILE PRO SER PRO LEU GLN TYR SER LYS VAL ILE SER ILE          
SEQRES  12 F  494  LEU GLU ASN GLU ASN TYR SER LYS ASN GLU SER ASP GLU          
SEQRES  13 F  494  LEU PHE PHE HIS LEU GLU ASN LYS ALA LYS LEU THR ARG          
SEQRES  14 F  494  GLU GLN ILE LEU VAL LEU THR MET SER MET LYS THR SER          
SEQRES  15 F  494  PHE LYS ASN LYS GLU PRO LEU ASP ILE LYS THR ARG THR          
SEQRES  16 F  494  GLN ILE LEU GLU ALA ASN SER ILE LEU GLU ASN LEU TRP          
SEQRES  17 F  494  LYS LEU GLN GLU ASP ILE GLY GLN TYR ILE ALA SER LYS          
SEQRES  18 F  494  ILE SER ILE ILE ALA PRO ASN VAL CYS PHE LEU VAL GLY          
SEQRES  19 F  494  PRO GLU ILE ALA ALA GLN LEU ILE ALA HIS ALA GLY GLY          
SEQRES  20 F  494  VAL LEU GLU PHE SER ARG ILE PRO SER CYS ASN ILE ALA          
SEQRES  21 F  494  SER ILE GLY LYS ASN LYS HIS LEU SER HIS GLU LEU HIS          
SEQRES  22 F  494  THR LEU GLU SER GLY VAL ARG GLN GLU GLY TYR LEU PHE          
SEQRES  23 F  494  ALA SER ASP MET ILE GLN LYS PHE PRO VAL SER VAL HIS          
SEQRES  24 F  494  LYS GLN MET LEU ARG MET LEU CYS ALA LYS VAL SER LEU          
SEQRES  25 F  494  ALA ALA ARG VAL ASP ALA GLY GLN LYS ASN GLY ASP ARG          
SEQRES  26 F  494  ASN THR VAL LEU ALA HIS LYS TRP LYS ALA GLU LEU SER          
SEQRES  27 F  494  LYS LYS ALA ARG LYS LEU SER GLU ALA PRO SER ILE SER          
SEQRES  28 F  494  GLU THR LYS ALA LEU PRO ILE PRO GLU ASP GLN PRO LYS          
SEQRES  29 F  494  LYS LYS ARG ALA GLY ARG LYS PHE ARG LYS TYR LYS GLU          
SEQRES  30 F  494  LYS PHE ARG LEU SER HIS VAL ARG GLN LEU GLN ASN ARG          
SEQRES  31 F  494  MET GLU PHE GLY LYS GLN GLU GLN THR VAL LEU ASP SER          
SEQRES  32 F  494  TYR GLY GLU GLU VAL GLY LEU GLY MET SER ASN THR SER          
SEQRES  33 F  494  LEU GLN GLN ALA VAL GLY ALA THR SER GLY SER ARG ARG          
SEQRES  34 F  494  SER ALA GLY ASN GLN ALA LYS LEU THR LYS VAL MET LYS          
SEQRES  35 F  494  HIS ARG ILE SER GLU ALA ASN GLN GLN ALA ASP GLU PHE          
SEQRES  36 F  494  LEU ILE SER LEU GLY HIS ASN THR GLU GLN PRO ASN LEU          
SEQRES  37 F  494  SER PRO GLU MET VAL GLN MET HIS LYS LYS GLN HIS THR          
SEQRES  38 F  494  ASN PRO GLU GLU GLU THR ASN TRP PHE SER GLY HIS GLY          
SEQRES   1 G  469  MET PRO PRO ARG ASN THR TYR GLU LYS GLY ASN PRO LYS          
SEQRES   2 G  469  ARG GLN ASN SER PRO TYR TYR LYS PRO SER PHE LEU ARG          
SEQRES   3 G  469  ARG GLU GLU THR THR ASN ASP GLU GLU LYS PHE GLN GLY          
SEQRES   4 G  469  HIS GLY LEU LYS THR GLU LEU HIS SER ALA LEU LYS SER          
SEQRES   5 G  469  SER ASN LEU ASN LEU ILE ARG ARG THR TYR GLN THR GLY          
SEQRES   6 G  469  GLU ASN PRO TYR LEU SER ASP PRO HIS ASP ARG GLY SER          
SEQRES   7 G  469  SER SER ARG PHE ASN ARG ARG TYR GLU ARG GLY LEU LYS          
SEQRES   8 G  469  PHE TYR GLN LYS GLY GLU ILE SER LYS ARG ILE ALA GLN          
SEQRES   9 G  469  GLU ARG THR LEU GLN LYS GLN GLN GLU GLU GLU GLU LEU          
SEQRES  10 G  469  LYS ARG LYS LEU LYS GLN GLU GLU ASP GLU LYS ASP LYS          
SEQRES  11 G  469  ARG LYS LEU ILE GLU SER GLY ASP LEU PRO ASN LEU GLU          
SEQRES  12 G  469  LEU HIS GLU ASP LYS PHE LEU LEU ASP LEU SER LYS PHE          
SEQRES  13 G  469  LYS ILE TYR TYR ASP ASN ASN HIS GLY TYR GLU TRP TRP          
SEQRES  14 G  469  ASP THR ALA TYR LEU ASP GLU LYS GLY GLU LEU MET GLU          
SEQRES  15 G  469  LYS TYR ASP MET ASN GLY THR SER PRO ALA GLU GLU LYS          
SEQRES  16 G  469  LEU ALA GLU ASP ILE ASP GLU VAL ASP ASP ASP ASP ASP          
SEQRES  17 G  469  ASP GLU HIS PRO SER ILE ARG TYR VAL ALA HIS PRO LEU          
SEQRES  18 G  469  PRO GLU LYS ILE ASN GLU ALA LYS VAL SER ILE LYS ALA          
SEQRES  19 G  469  TYR LEU THR GLN HIS GLU ARG LYS ARG LEU ARG ARG ASN          
SEQRES  20 G  469  ARG ARG LYS MET ALA ARG GLU ALA ARG GLU ILE LYS ILE          
SEQRES  21 G  469  LYS LEU GLY LEU LEU PRO LYS PRO GLU PRO LYS VAL LYS          
SEQRES  22 G  469  LEU SER ASN MET MET SER VAL PHE GLU ASN ASP GLN ASN          
SEQRES  23 G  469  ILE THR ASP PRO THR ALA TRP GLU LYS VAL VAL LYS ASP          
SEQRES  24 G  469  GLN VAL ASP LEU ARG LYS ARG LYS HIS LEU GLU GLU ASN          
SEQRES  25 G  469  GLU ARG ARG HIS GLU ASP ALA ILE LYS ARG ARG LYS GLU          
SEQRES  26 G  469  ALA VAL ASN MET ASN VAL GLU LYS PRO THR VAL TYR HIS          
SEQRES  27 G  469  CYS LYS VAL PHE GLN PHE LYS ASN LEU GLN ASN PRO LYS          
SEQRES  28 G  469  ILE ARG PHE LYS LEU LYS MET ASN SER LYS GLU LEU SER          
SEQRES  29 G  469  LEU LYS GLY LEU CYS LEU ARG ILE ARG ASP ASP GLY PRO          
SEQRES  30 G  469  GLY ILE ILE ILE VAL VAL GLY ASN GLU LYS SER CYS LYS          
SEQRES  31 G  469  PHE TYR GLU ASN LEU VAL MET LYS ARG ILE LYS TRP ASN          
SEQRES  32 G  469  GLU ASP PHE GLU LEU HIS THR ASN THR GLY ASP ILE LYS          
SEQRES  33 G  469  MET ASP MET HIS ASN ASN SER ILE SER LYS THR TRP GLU          
SEQRES  34 G  469  GLY TYR LEU GLN ASP CYS LYS PHE LYS GLY TRP PHE MET          
SEQRES  35 G  469  LYS VAL CYS ASN ASP GLN ASP SER LEU LEU ARG THR LEU          
SEQRES  36 G  469  GLY GLN PHE ASP SER GLU HIS PHE TYR SER PRO VAL GLN          
SEQRES  37 G  469  THR                                                          
SEQRES   1 B 2163  MET THR GLU HIS GLU THR LYS ASP LYS ALA LYS LYS ILE          
SEQRES   2 B 2163  ARG GLU ILE TYR ARG TYR ASP GLU MET SER ASN LYS VAL          
SEQRES   3 B 2163  LEU LYS VAL ASP LYS ARG PHE MET ASN THR SER GLN ASN          
SEQRES   4 B 2163  PRO GLN ARG ASP ALA GLU ILE SER GLN PRO LYS SER MET          
SEQRES   5 B 2163  SER GLY ARG ILE SER ALA LYS ASP MET GLY GLN GLY LEU          
SEQRES   6 B 2163  CYS ASN ASN ILE ASN LYS GLY LEU LYS GLU ASN ASP VAL          
SEQRES   7 B 2163  ALA VAL GLU LYS THR GLY LYS SER ALA SER LEU LYS LYS          
SEQRES   8 B 2163  ILE GLN GLN HIS ASN THR ILE LEU ASN SER SER SER ASP          
SEQRES   9 B 2163  PHE ARG LEU HIS TYR TYR PRO LYS ASP PRO SER ASN VAL          
SEQRES  10 B 2163  GLU THR TYR GLU GLN ILE LEU GLN TRP VAL THR GLU VAL          
SEQRES  11 B 2163  LEU GLY ASN ASP ILE PRO HIS ASP LEU ILE ILE GLY THR          
SEQRES  12 B 2163  ALA ASP ILE PHE ILE ARG GLN LEU LYS GLU ASN GLU GLU          
SEQRES  13 B 2163  ASN GLU ASP GLY ASN ILE GLU GLU ARG LYS GLU LYS ILE          
SEQRES  14 B 2163  GLN HIS GLU LEU GLY ILE ASN ILE ASP SER LEU LYS PHE          
SEQRES  15 B 2163  ASN GLU LEU VAL LYS LEU MET LYS ASN ILE THR ASP TYR          
SEQRES  16 B 2163  GLU THR HIS PRO ASP ASN SER ASN LYS GLN ALA VAL ALA          
SEQRES  17 B 2163  ILE LEU ALA ASP ASP GLU LYS SER ASP GLU GLU GLU VAL          
SEQRES  18 B 2163  THR GLU MET SER ASN ASN ALA ASN VAL LEU GLY GLY GLU          
SEQRES  19 B 2163  ILE ASN ASP ASN GLU ASP ASP ASP GLU GLU TYR ASP TYR          
SEQRES  20 B 2163  ASN ASP VAL GLU VAL ASN SER LYS LYS LYS ASN LYS ARG          
SEQRES  21 B 2163  ALA LEU PRO ASN ILE GLU ASN ASP ILE ILE LYS LEU SER          
SEQRES  22 B 2163  ASP SER LYS THR SER ASN ILE GLU SER VAL PRO ILE TYR          
SEQRES  23 B 2163  SER ILE ASP GLU PHE PHE LEU GLN ARG LYS LEU ARG SER          
SEQRES  24 B 2163  GLU LEU GLY TYR LYS ASP THR SER VAL ILE GLN ASP LEU          
SEQRES  25 B 2163  SER GLU LYS ILE LEU ASN ASP ILE GLU THR LEU GLU HIS          
SEQRES  26 B 2163  ASN PRO VAL ALA LEU GLU GLN LYS LEU VAL ASP LEU LEU          
SEQRES  27 B 2163  LYS PHE GLU ASN ILE SER LEU ALA GLU PHE ILE LEU LYS          
SEQRES  28 B 2163  ASN ARG SER THR ILE PHE TRP GLY ILE ARG LEU ALA LYS          
SEQRES  29 B 2163  SER THR GLU ASN GLU ILE PRO ASN LEU ILE GLU LYS MET          
SEQRES  30 B 2163  VAL ALA LYS GLY LEU ASN ASP LEU VAL GLU GLN TYR LYS          
SEQRES  31 B 2163  PHE ARG GLU THR THR HIS SER LYS ARG GLU LEU ASP SER          
SEQRES  32 B 2163  GLY ASP ASP GLN PRO GLN SER SER GLU ALA LYS ARG THR          
SEQRES  33 B 2163  LYS PHE SER ASN PRO ALA ILE PRO PRO VAL ILE ASP LEU          
SEQRES  34 B 2163  GLU LYS ILE LYS PHE ASP GLU SER SER LYS LEU MET THR          
SEQRES  35 B 2163  VAL THR LYS VAL SER LEU PRO GLU GLY SER PHE LYS ARG          
SEQRES  36 B 2163  VAL LYS PRO GLN TYR ASP GLU ILE HIS ILE PRO ALA PRO          
SEQRES  37 B 2163  SER LYS PRO VAL ILE ASP TYR GLU LEU LYS GLU ILE THR          
SEQRES  38 B 2163  SER LEU PRO ASP TRP CYS GLN GLU ALA PHE PRO SER SER          
SEQRES  39 B 2163  GLU THR THR SER LEU ASN PRO ILE GLN SER LYS VAL PHE          
SEQRES  40 B 2163  HIS ALA ALA PHE GLU GLY ASP SER ASN MET LEU ILE CYS          
SEQRES  41 B 2163  ALA PRO THR GLY SER GLY LYS THR ASN ILE ALA LEU LEU          
SEQRES  42 B 2163  THR VAL LEU LYS ALA LEU SER HIS HIS TYR ASN PRO LYS          
SEQRES  43 B 2163  THR LYS LYS LEU ASN LEU SER ALA PHE LYS ILE VAL TYR          
SEQRES  44 B 2163  ILE ALA PRO LEU LYS ALA LEU VAL GLN GLU GLN VAL ARG          
SEQRES  45 B 2163  GLU PHE GLN ARG ARG LEU ALA PHE LEU GLY ILE LYS VAL          
SEQRES  46 B 2163  ALA GLU LEU THR GLY ASP SER ARG LEU SER ARG LYS GLN          
SEQRES  47 B 2163  ILE ASP GLU THR GLN VAL LEU VAL SER THR PRO GLU LYS          
SEQRES  48 B 2163  TRP ASP ILE THR THR ARG ASN SER ASN ASN LEU ALA ILE          
SEQRES  49 B 2163  VAL GLU LEU VAL ARG LEU LEU ILE ILE ASP GLU ILE HIS          
SEQRES  50 B 2163  LEU LEU HIS ASP ASP ARG GLY PRO VAL LEU GLU SER ILE          
SEQRES  51 B 2163  VAL ALA ARG THR PHE TRP ALA SER LYS TYR GLY GLN GLU          
SEQRES  52 B 2163  TYR PRO ARG ILE ILE GLY LEU SER ALA THR LEU PRO ASN          
SEQRES  53 B 2163  TYR GLU ASP VAL GLY ARG PHE LEU ARG VAL PRO LYS GLU          
SEQRES  54 B 2163  GLY LEU PHE TYR PHE ASP SER SER PHE ARG PRO CYS PRO          
SEQRES  55 B 2163  LEU SER GLN GLN PHE CYS GLY ILE LYS GLU ARG ASN SER          
SEQRES  56 B 2163  LEU LYS LYS LEU LYS ALA MET ASN ASP ALA CYS TYR GLU          
SEQRES  57 B 2163  LYS VAL LEU GLU SER ILE ASN GLU GLY ASN GLN ILE ILE          
SEQRES  58 B 2163  VAL PHE VAL HIS SER ARG LYS GLU THR SER ARG THR ALA          
SEQRES  59 B 2163  THR TRP LEU LYS ASN LYS PHE ALA GLU GLU ASN ILE THR          
SEQRES  60 B 2163  HIS LYS LEU THR LYS ASN ASP ALA GLY SER LYS GLN ILE          
SEQRES  61 B 2163  LEU LYS THR GLU ALA ALA ASN VAL LEU ASP PRO SER LEU          
SEQRES  62 B 2163  ARG LYS LEU ILE GLU SER GLY ILE GLY THR HIS HIS ALA          
SEQRES  63 B 2163  GLY LEU THR ARG SER ASP ARG SER LEU SER GLU ASP LEU          
SEQRES  64 B 2163  PHE ALA ASP GLY LEU LEU GLN VAL LEU VAL CYS THR ALA          
SEQRES  65 B 2163  THR LEU ALA TRP GLY VAL ASN LEU PRO ALA HIS THR VAL          
SEQRES  66 B 2163  ILE ILE LYS GLY THR ASP VAL TYR SER PRO GLU LYS GLY          
SEQRES  67 B 2163  SER TRP GLU GLN LEU SER PRO GLN ASP VAL LEU GLN MET          
SEQRES  68 B 2163  LEU GLY ARG ALA GLY ARG PRO ARG TYR ASP THR PHE GLY          
SEQRES  69 B 2163  GLU GLY ILE ILE ILE THR ASP GLN SER ASN VAL GLN TYR          
SEQRES  70 B 2163  TYR LEU SER VAL LEU ASN GLN GLN LEU PRO ILE GLU SER          
SEQRES  71 B 2163  GLN PHE VAL SER LYS LEU VAL ASP ASN LEU ASN ALA GLU          
SEQRES  72 B 2163  VAL VAL ALA GLY ASN ILE LYS CYS ARG ASN ASP ALA VAL          
SEQRES  73 B 2163  ASN TRP LEU ALA TYR THR TYR LEU TYR VAL ARG MET LEU          
SEQRES  74 B 2163  ALA SER PRO MET LEU TYR LYS VAL PRO ASP ILE SER SER          
SEQRES  75 B 2163  ASP GLY GLN LEU LYS LYS PHE ARG GLU SER LEU VAL HIS          
SEQRES  76 B 2163  SER ALA LEU CYS ILE LEU LYS GLU GLN GLU LEU VAL LEU          
SEQRES  77 B 2163  TYR ASP ALA GLU ASN ASP VAL ILE GLU ALA THR ASP LEU          
SEQRES  78 B 2163  GLY ASN ILE ALA SER SER PHE TYR ILE ASN HIS ALA SER          
SEQRES  79 B 2163  MET ASP VAL TYR ASN ARG GLU LEU ASP GLU HIS THR THR          
SEQRES  80 B 2163  GLN ILE ASP LEU PHE ARG ILE PHE SER MET SER GLU GLU          
SEQRES  81 B 2163  PHE LYS TYR VAL SER VAL ARG TYR GLU GLU LYS ARG GLU          
SEQRES  82 B 2163  LEU LYS GLN LEU LEU GLU LYS ALA PRO ILE PRO ILE ARG          
SEQRES  83 B 2163  GLU ASP ILE ASP ASP PRO LEU ALA LYS VAL ASN VAL LEU          
SEQRES  84 B 2163  LEU GLN SER TYR PHE SER GLN LEU LYS PHE GLU GLY PHE          
SEQRES  85 B 2163  ALA LEU ASN SER ASP ILE VAL PHE ILE HIS GLN ASN ALA          
SEQRES  86 B 2163  GLY ARG LEU LEU ARG ALA MET PHE GLU ILE CYS LEU LYS          
SEQRES  87 B 2163  ARG GLY TRP GLY HIS PRO THR ARG MET LEU LEU ASN LEU          
SEQRES  88 B 2163  CYS LYS SER ALA THR THR LYS MET TRP PRO THR ASN CYS          
SEQRES  89 B 2163  PRO LEU ARG GLN PHE LYS THR CYS PRO VAL GLU VAL ILE          
SEQRES  90 B 2163  LYS ARG LEU GLU ALA SER THR VAL PRO TRP GLY ASP TYR          
SEQRES  91 B 2163  LEU GLN LEU GLU THR PRO ALA GLU VAL GLY ARG ALA ILE          
SEQRES  92 B 2163  ARG SER GLU LYS TYR GLY LYS GLN VAL TYR ASP LEU LEU          
SEQRES  93 B 2163  LYS ARG PHE PRO LYS MET SER VAL THR CYS ASN ALA GLN          
SEQRES  94 B 2163  PRO ILE THR ARG SER VAL MET ARG PHE ASN ILE GLU ILE          
SEQRES  95 B 2163  ILE ALA ASP TRP ILE TRP ASP MET ASN VAL HIS GLY SER          
SEQRES  96 B 2163  LEU GLU PRO PHE LEU LEU MET LEU GLU ASP THR ASP GLY          
SEQRES  97 B 2163  ASP SER ILE LEU TYR TYR ASP VAL LEU PHE ILE THR PRO          
SEQRES  98 B 2163  ASP ILE VAL GLY HIS GLU PHE THR LEU SER PHE THR TYR          
SEQRES  99 B 2163  GLU LEU LYS GLN HIS ASN GLN ASN ASN LEU PRO PRO ASN          
SEQRES 100 B 2163  PHE PHE LEU THR LEU ILE SER GLU ASN TRP TRP HIS SER          
SEQRES 101 B 2163  GLU PHE GLU ILE PRO VAL SER PHE ASN GLY PHE LYS LEU          
SEQRES 102 B 2163  PRO LYS LYS PHE PRO PRO PRO THR PRO LEU LEU GLU ASN          
SEQRES 103 B 2163  ILE SER ILE SER THR SER GLU LEU GLY ASN ASP ASP PHE          
SEQRES 104 B 2163  SER GLU VAL PHE GLU PHE LYS THR PHE ASN LYS ILE GLN          
SEQRES 105 B 2163  SER GLN VAL PHE GLU SER LEU TYR ASN SER ASN ASP SER          
SEQRES 106 B 2163  VAL PHE VAL GLY SER GLY LYS GLY THR GLY LYS THR ALA          
SEQRES 107 B 2163  MET ALA GLU LEU ALA LEU LEU ASN HIS TRP ARG GLN ASN          
SEQRES 108 B 2163  LYS GLY ARG ALA VAL TYR ILE ASN PRO SER GLY GLU LYS          
SEQRES 109 B 2163  ILE ASP PHE LEU LEU SER ASP TRP ASN LYS ARG PHE SER          
SEQRES 110 B 2163  HIS LEU ALA GLY GLY LYS ILE ILE ASN LYS LEU GLY ASN          
SEQRES 111 B 2163  ASP PRO SER LEU ASN LEU LYS LEU LEU ALA LYS SER HIS          
SEQRES 112 B 2163  VAL LEU LEU ALA THR PRO VAL GLN PHE GLU LEU LEU SER          
SEQRES 113 B 2163  ARG ARG TRP ARG GLN ARG LYS ASN ILE GLN SER LEU GLU          
SEQRES 114 B 2163  LEU MET ILE TYR ASP ASP ALA HIS GLU ILE SER GLN GLY          
SEQRES 115 B 2163  VAL TYR GLY ALA VAL TYR GLU THR LEU ILE SER ARG MET          
SEQRES 116 B 2163  ILE PHE ILE ALA THR GLN LEU GLU LYS LYS ILE ARG PHE          
SEQRES 117 B 2163  VAL CYS LEU SER ASN CYS LEU ALA ASN ALA ARG ASP PHE          
SEQRES 118 B 2163  GLY GLU TRP ALA GLY MET THR LYS SER ASN ILE TYR ASN          
SEQRES 119 B 2163  PHE SER PRO SER GLU ARG ILE GLU PRO LEU GLU ILE ASN          
SEQRES 120 B 2163  ILE GLN SER PHE LYS ASP VAL GLU HIS ILE SER PHE ASN          
SEQRES 121 B 2163  PHE SER MET LEU GLN MET ALA PHE GLU ALA SER ALA ALA          
SEQRES 122 B 2163  ALA ALA GLY ASN ARG ASN SER SER SER VAL PHE LEU PRO          
SEQRES 123 B 2163  SER ARG LYS ASP CYS MET GLU VAL ALA SER ALA PHE MET          
SEQRES 124 B 2163  LYS PHE SER LYS ALA ILE GLU TRP ASP MET LEU ASN VAL          
SEQRES 125 B 2163  GLU GLU GLU GLN ILE VAL PRO TYR ILE GLU LYS LEU THR          
SEQRES 126 B 2163  ASP GLY HIS LEU ARG ALA PRO LEU LYS HIS GLY VAL GLY          
SEQRES 127 B 2163  ILE LEU TYR LYS GLY MET ALA SER ASN ASP GLU ARG ILE          
SEQRES 128 B 2163  VAL LYS ARG LEU TYR GLU TYR GLY ALA VAL SER VAL LEU          
SEQRES 129 B 2163  LEU ILE SER LYS ASP CYS SER ALA PHE ALA CYS LYS THR          
SEQRES 130 B 2163  ASP GLU VAL ILE ILE LEU GLY THR ASN LEU TYR ASP GLY          
SEQRES 131 B 2163  ALA GLU HIS LYS TYR MET PRO TYR THR ILE ASN GLU LEU          
SEQRES 132 B 2163  LEU GLU MET VAL GLY LEU ALA SER GLY ASN ASP SER MET          
SEQRES 133 B 2163  ALA GLY LYS VAL LEU ILE LEU THR SER HIS ASN MET LYS          
SEQRES 134 B 2163  ALA TYR TYR LYS LYS PHE LEU ILE GLU PRO LEU PRO THR          
SEQRES 135 B 2163  GLU SER TYR LEU GLN TYR ILE ILE HIS ASP THR LEU ASN          
SEQRES 136 B 2163  ASN GLU ILE ALA ASN SER ILE ILE GLN SER LYS GLN ASP          
SEQRES 137 B 2163  CYS VAL ASP TRP PHE THR TYR SER TYR PHE TYR ARG ARG          
SEQRES 138 B 2163  ILE HIS VAL ASN PRO SER TYR TYR GLY VAL ARG ASP THR          
SEQRES 139 B 2163  SER PRO HIS GLY ILE SER VAL PHE LEU SER ASN LEU VAL          
SEQRES 140 B 2163  GLU THR CYS LEU ASN ASP LEU VAL GLU SER SER PHE ILE          
SEQRES 141 B 2163  GLU ILE ASP ASP THR GLU ALA GLU VAL THR ALA GLU VAL          
SEQRES 142 B 2163  ASN GLY GLY ASP ASP GLU ALA THR GLU ILE ILE SER THR          
SEQRES 143 B 2163  LEU SER ASN GLY LEU ILE ALA SER HIS TYR GLY VAL SER          
SEQRES 144 B 2163  PHE PHE THR ILE GLN SER PHE VAL SER SER LEU SER ASN          
SEQRES 145 B 2163  THR SER THR LEU LYS ASN MET LEU TYR VAL LEU SER THR          
SEQRES 146 B 2163  ALA VAL GLU PHE GLU SER VAL PRO LEU ARG LYS GLY ASP          
SEQRES 147 B 2163  ARG ALA LEU LEU VAL LYS LEU SER LYS ARG LEU PRO LEU          
SEQRES 148 B 2163  ARG PHE PRO GLU HIS THR SER SER GLY SER VAL SER PHE          
SEQRES 149 B 2163  LYS VAL PHE LEU LEU LEU GLN ALA TYR PHE SER ARG LEU          
SEQRES 150 B 2163  GLU LEU PRO VAL ASP PHE GLN ASN ASP LEU LYS ASP ILE          
SEQRES 151 B 2163  LEU GLU LYS VAL VAL PRO LEU ILE ASN VAL VAL VAL ASP          
SEQRES 152 B 2163  ILE LEU SER ALA ASN GLY TYR LEU ASN ALA THR THR ALA          
SEQRES 153 B 2163  MET ASP LEU ALA GLN MET LEU ILE GLN GLY VAL TRP ASP          
SEQRES 154 B 2163  VAL ASP ASN PRO LEU ARG GLN ILE PRO HIS PHE ASN ASN          
SEQRES 155 B 2163  LYS ILE LEU GLU LYS CYS LYS GLU ILE ASN VAL GLU THR          
SEQRES 156 B 2163  VAL TYR ASP ILE MET ALA LEU GLU ASP GLU GLU ARG ASP          
SEQRES 157 B 2163  GLU ILE LEU THR LEU THR ASP SER GLN LEU ALA GLN VAL          
SEQRES 158 B 2163  ALA ALA PHE VAL ASN ASN TYR PRO ASN VAL GLU LEU THR          
SEQRES 159 B 2163  TYR SER LEU ASN ASN SER ASP SER LEU ILE SER GLY VAL          
SEQRES 160 B 2163  LYS GLN LYS ILE THR ILE GLN LEU THR ARG ASP VAL GLU          
SEQRES 161 B 2163  PRO GLU ASN LEU GLN VAL THR SER GLU LYS TYR PRO PHE          
SEQRES 162 B 2163  ASP LYS LEU GLU SER TRP TRP LEU VAL LEU GLY GLU VAL          
SEQRES 163 B 2163  SER LYS LYS GLU LEU TYR ALA ILE LYS LYS VAL THR LEU          
SEQRES 164 B 2163  ASN LYS GLU THR GLN GLN TYR GLU LEU GLU PHE ASP THR          
SEQRES 165 B 2163  PRO THR SER GLY LYS HIS ASN LEU THR ILE TRP CYS VAL          
SEQRES 166 B 2163  CYS ASP SER TYR LEU ASP ALA ASP LYS GLU LEU SER PHE          
SEQRES 167 B 2163  GLU ILE ASN VAL LYS                                          
SEQRES   1 x  100  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   2 x  100  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   3 x  100  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   4 x  100  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   5 x  100  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   6 x  100  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   7 x  100  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   8 x  100  UNK UNK UNK UNK UNK UNK UNK UNK UNK                          
SEQRES   1 k  196  MET SER LYS ILE GLN VAL ALA HIS SER SER ARG LEU ALA          
SEQRES   2 k  196  ASN LEU ILE ASP TYR LYS LEU ARG VAL LEU THR GLN ASP          
SEQRES   3 k  196  GLY ARG VAL TYR ILE GLY GLN LEU MET ALA PHE ASP LYS          
SEQRES   4 k  196  HIS MET ASN LEU VAL LEU ASN GLU CYS ILE GLU GLU ARG          
SEQRES   5 k  196  VAL PRO LYS THR GLN LEU ASP LYS LEU ARG PRO ARG LYS          
SEQRES   6 k  196  ASP SER LYS ASP GLY THR THR LEU ASN ILE LYS VAL GLU          
SEQRES   7 k  196  LYS ARG VAL LEU GLY LEU THR ILE LEU ARG GLY GLU GLN          
SEQRES   8 k  196  ILE LEU SER THR VAL VAL GLU ASP LYS PRO LEU LEU SER          
SEQRES   9 k  196  LYS LYS GLU ARG LEU VAL ARG ASP LYS LYS GLU LYS LYS          
SEQRES  10 k  196  GLN ALA GLN LYS GLN THR LYS LEU ARG LYS GLU LYS GLU          
SEQRES  11 k  196  LYS LYS PRO GLY LYS ILE ALA LYS PRO ASN THR ALA ASN          
SEQRES  12 k  196  ALA LYS HIS THR SER SER ASN SER ARG GLU ILE ALA GLN          
SEQRES  13 k  196  PRO SER SER SER ARG TYR ASN GLY GLY ASN ASP ASN ILE          
SEQRES  14 k  196  GLY ALA ASN ARG SER ARG PHE ASN ASN GLU ALA PRO PRO          
SEQRES  15 k  196  GLN THR ARG LYS PHE GLN PRO PRO PRO GLY PHE LYS ARG          
SEQRES  16 k  196  LYS                                                          
SEQRES   1 l  146  MET LYS LEU VAL ASN PHE LEU LYS LYS LEU ARG ASN GLU          
SEQRES   2 l  146  GLN VAL THR ILE GLU LEU LYS ASN GLY THR THR VAL TRP          
SEQRES   3 l  146  GLY THR LEU GLN SER VAL SER PRO GLN MET ASN ALA ILE          
SEQRES   4 l  146  LEU THR ASP VAL LYS LEU THR LEU PRO GLN PRO ARG LEU          
SEQRES   5 l  146  ASN LYS LEU ASN SER ASN GLY ILE ALA MET ALA SER LEU          
SEQRES   6 l  146  TYR LEU THR GLY GLY GLN GLN PRO THR ALA SER ASP ASN          
SEQRES   7 l  146  ILE ALA SER LEU GLN TYR ILE ASN ILE ARG GLY ASN THR          
SEQRES   8 l  146  ILE ARG GLN ILE ILE LEU PRO ASP SER LEU ASN LEU ASP          
SEQRES   9 l  146  SER LEU LEU VAL ASP GLN LYS GLN LEU ASN SER LEU ARG          
SEQRES  10 l  146  ARG SER GLY GLN ILE ALA ASN ASP PRO SER LYS LYS ARG          
SEQRES  11 l  146  ARG ARG ASP PHE GLY ALA PRO ALA ASN LYS ARG PRO ARG          
SEQRES  12 l  146  ARG GLY LEU                                                  
SEQRES   1 m  110  MET SER SER GLN ILE ILE ASP ARG PRO LYS HIS GLU LEU          
SEQRES   2 m  110  SER ARG ALA GLU LEU GLU GLU LEU GLU GLU PHE GLU PHE          
SEQRES   3 m  110  LYS HIS GLY PRO MET SER LEU ILE ASN ASP ALA MET VAL          
SEQRES   4 m  110  THR ARG THR PRO VAL ILE ILE SER LEU ARG ASN ASN HIS          
SEQRES   5 m  110  LYS ILE ILE ALA ARG VAL LYS ALA PHE ASP ARG HIS CYS          
SEQRES   6 m  110  ASN MET VAL LEU GLU ASN VAL LYS GLU LEU TRP THR GLU          
SEQRES   7 m  110  LYS LYS GLY LYS ASN VAL ILE ASN ARG GLU ARG PHE ILE          
SEQRES   8 m  110  SER LYS LEU PHE LEU ARG GLY ASP SER VAL ILE VAL VAL          
SEQRES   9 m  110  LEU LYS THR PRO VAL GLU                                      
SEQRES   1 n  101  MET THR MET ASN GLY ILE PRO VAL LYS LEU LEU ASN GLU          
SEQRES   2 n  101  ALA GLN GLY HIS ILE VAL SER LEU GLU LEU THR THR GLY          
SEQRES   3 n  101  ALA THR TYR ARG GLY LYS LEU VAL GLU SER GLU ASP SER          
SEQRES   4 n  101  MET ASN VAL GLN LEU ARG ASP VAL ILE ALA THR GLU PRO          
SEQRES   5 n  101  GLN GLY ALA VAL THR HIS MET ASP GLN ILE PHE VAL ARG          
SEQRES   6 n  101  GLY SER GLN ILE LYS PHE ILE VAL VAL PRO ASP LEU LEU          
SEQRES   7 n  101  LYS ASN ALA PRO LEU PHE LYS LYS ASN SER SER ARG PRO          
SEQRES   8 n  101  MET PRO PRO ILE ARG GLY PRO LYS ARG ARG                      
SEQRES   1 p   94  MET SER ASN LYS VAL LYS THR LYS ALA MET VAL PRO PRO          
SEQRES   2 p   94  ILE ASN CYS ILE PHE ASN PHE LEU GLN GLN GLN THR PRO          
SEQRES   3 p   94  VAL THR ILE TRP LEU PHE GLU GLN ILE GLY ILE ARG ILE          
SEQRES   4 p   94  LYS GLY LYS ILE VAL GLY PHE ASP GLU PHE MET ASN VAL          
SEQRES   5 p   94  VAL ILE ASP GLU ALA VAL GLU ILE PRO VAL ASN SER ALA          
SEQRES   6 p   94  ASP GLY LYS GLU ASP VAL GLU LYS GLY THR PRO LEU GLY          
SEQRES   7 p   94  LYS ILE LEU LEU LYS GLY ASP ASN ILE THR LEU ILE THR          
SEQRES   8 p   94  SER ALA ASP                                                  
SEQRES   1 q   86  MET SER GLU SER SER ASP ILE SER ALA MET GLN PRO VAL          
SEQRES   2 q   86  ASN PRO LYS PRO PHE LEU LYS GLY LEU VAL ASN HIS ARG          
SEQRES   3 q   86  VAL GLY VAL LYS LEU LYS PHE ASN SER THR GLU TYR ARG          
SEQRES   4 q   86  GLY THR LEU VAL SER THR ASP ASN TYR PHE ASN LEU GLN          
SEQRES   5 q   86  LEU ASN GLU ALA GLU GLU PHE VAL ALA GLY VAL SER HIS          
SEQRES   6 q   86  GLY THR LEU GLY GLU ILE PHE ILE ARG CYS ASN ASN VAL          
SEQRES   7 q   86  LEU TYR ILE ARG GLU LEU PRO ASN                              
SEQRES   1 r   77  MET VAL SER THR PRO GLU LEU LYS LYS TYR MET ASP LYS          
SEQRES   2 r   77  LYS ILE LEU LEU ASN ILE ASN GLY SER ARG LYS VAL ALA          
SEQRES   3 r   77  GLY ILE LEU ARG GLY TYR ASP ILE PHE LEU ASN VAL VAL          
SEQRES   4 r   77  LEU ASP ASP ALA MET GLU ILE ASN GLY GLU ASP PRO ALA          
SEQRES   5 r   77  ASN ASN HIS GLN LEU GLY LEU GLN THR VAL ILE ARG GLY          
SEQRES   6 r   77  ASN SER ILE ILE SER LEU GLU ALA LEU ASP ALA ILE              
SEQRES   1 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   2 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   3 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   4 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   5 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   6 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   7 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   8 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   9 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  10 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  11 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  12 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  13 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  14 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  15 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  16 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  17 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  18 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  19 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  20 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK ARG          
SEQRES  21 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  22 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  23 E  328  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  24 E  328  UNK UNK UNK UNK UNK UNK UNK UNK THR THR LYS GLU ALA          
SEQRES  25 E  328  TYR LYS LYS LEU SER GLN LYS PHE HIS GLY THR LYS SER          
SEQRES  26 E  328  ASN LYS LYS                                                  
SEQRES   1 b  196  MET SER LYS ILE GLN VAL ALA HIS SER SER ARG LEU ALA          
SEQRES   2 b  196  ASN LEU ILE ASP TYR LYS LEU ARG VAL LEU THR GLN ASP          
SEQRES   3 b  196  GLY ARG VAL TYR ILE GLY GLN LEU MET ALA PHE ASP LYS          
SEQRES   4 b  196  HIS MET ASN LEU VAL LEU ASN GLU CYS ILE GLU GLU ARG          
SEQRES   5 b  196  VAL PRO LYS THR GLN LEU ASP LYS LEU ARG PRO ARG LYS          
SEQRES   6 b  196  ASP SER LYS ASP GLY THR THR LEU ASN ILE LYS VAL GLU          
SEQRES   7 b  196  LYS ARG VAL LEU GLY LEU THR ILE LEU ARG GLY GLU GLN          
SEQRES   8 b  196  ILE LEU SER THR VAL VAL GLU ASP LYS PRO LEU LEU SER          
SEQRES   9 b  196  LYS LYS GLU ARG LEU VAL ARG ASP LYS LYS GLU LYS LYS          
SEQRES  10 b  196  GLN ALA GLN LYS GLN THR LYS LEU ARG LYS GLU LYS GLU          
SEQRES  11 b  196  LYS LYS PRO GLY LYS ILE ALA LYS PRO ASN THR ALA ASN          
SEQRES  12 b  196  ALA LYS HIS THR SER SER ASN SER ARG GLU ILE ALA GLN          
SEQRES  13 b  196  PRO SER SER SER ARG TYR ASN GLY GLY ASN ASP ASN ILE          
SEQRES  14 b  196  GLY ALA ASN ARG SER ARG PHE ASN ASN GLU ALA PRO PRO          
SEQRES  15 b  196  GLN THR ARG LYS PHE GLN PRO PRO PRO GLY PHE LYS ARG          
SEQRES  16 b  196  LYS                                                          
SEQRES   1 e   94  MET SER ASN LYS VAL LYS THR LYS ALA MET VAL PRO PRO          
SEQRES   2 e   94  ILE ASN CYS ILE PHE ASN PHE LEU GLN GLN GLN THR PRO          
SEQRES   3 e   94  VAL THR ILE TRP LEU PHE GLU GLN ILE GLY ILE ARG ILE          
SEQRES   4 e   94  LYS GLY LYS ILE VAL GLY PHE ASP GLU PHE MET ASN VAL          
SEQRES   5 e   94  VAL ILE ASP GLU ALA VAL GLU ILE PRO VAL ASN SER ALA          
SEQRES   6 e   94  ASP GLY LYS GLU ASP VAL GLU LYS GLY THR PRO LEU GLY          
SEQRES   7 e   94  LYS ILE LEU LEU LYS GLY ASP ASN ILE THR LEU ILE THR          
SEQRES   8 e   94  SER ALA ASP                                                  
SEQRES   1 f   86  MET SER GLU SER SER ASP ILE SER ALA MET GLN PRO VAL          
SEQRES   2 f   86  ASN PRO LYS PRO PHE LEU LYS GLY LEU VAL ASN HIS ARG          
SEQRES   3 f   86  VAL GLY VAL LYS LEU LYS PHE ASN SER THR GLU TYR ARG          
SEQRES   4 f   86  GLY THR LEU VAL SER THR ASP ASN TYR PHE ASN LEU GLN          
SEQRES   5 f   86  LEU ASN GLU ALA GLU GLU PHE VAL ALA GLY VAL SER HIS          
SEQRES   6 f   86  GLY THR LEU GLY GLU ILE PHE ILE ARG CYS ASN ASN VAL          
SEQRES   7 f   86  LEU TYR ILE ARG GLU LEU PRO ASN                              
SEQRES   1 g   77  MET VAL SER THR PRO GLU LEU LYS LYS TYR MET ASP LYS          
SEQRES   2 g   77  LYS ILE LEU LEU ASN ILE ASN GLY SER ARG LYS VAL ALA          
SEQRES   3 g   77  GLY ILE LEU ARG GLY TYR ASP ILE PHE LEU ASN VAL VAL          
SEQRES   4 g   77  LEU ASP ASP ALA MET GLU ILE ASN GLY GLU ASP PRO ALA          
SEQRES   5 g   77  ASN ASN HIS GLN LEU GLY LEU GLN THR VAL ILE ARG GLY          
SEQRES   6 g   77  ASN SER ILE ILE SER LEU GLU ALA LEU ASP ALA ILE              
SEQRES   1 d  101  MET THR MET ASN GLY ILE PRO VAL LYS LEU LEU ASN GLU          
SEQRES   2 d  101  ALA GLN GLY HIS ILE VAL SER LEU GLU LEU THR THR GLY          
SEQRES   3 d  101  ALA THR TYR ARG GLY LYS LEU VAL GLU SER GLU ASP SER          
SEQRES   4 d  101  MET ASN VAL GLN LEU ARG ASP VAL ILE ALA THR GLU PRO          
SEQRES   5 d  101  GLN GLY ALA VAL THR HIS MET ASP GLN ILE PHE VAL ARG          
SEQRES   6 d  101  GLY SER GLN ILE LYS PHE ILE VAL VAL PRO ASP LEU LEU          
SEQRES   7 d  101  LYS ASN ALA PRO LEU PHE LYS LYS ASN SER SER ARG PRO          
SEQRES   8 d  101  MET PRO PRO ILE ARG GLY PRO LYS ARG ARG                      
SEQRES   1 h  146  MET LYS LEU VAL ASN PHE LEU LYS LYS LEU ARG ASN GLU          
SEQRES   2 h  146  GLN VAL THR ILE GLU LEU LYS ASN GLY THR THR VAL TRP          
SEQRES   3 h  146  GLY THR LEU GLN SER VAL SER PRO GLN MET ASN ALA ILE          
SEQRES   4 h  146  LEU THR ASP VAL LYS LEU THR LEU PRO GLN PRO ARG LEU          
SEQRES   5 h  146  ASN LYS LEU ASN SER ASN GLY ILE ALA MET ALA SER LEU          
SEQRES   6 h  146  TYR LEU THR GLY GLY GLN GLN PRO THR ALA SER ASP ASN          
SEQRES   7 h  146  ILE ALA SER LEU GLN TYR ILE ASN ILE ARG GLY ASN THR          
SEQRES   8 h  146  ILE ARG GLN ILE ILE LEU PRO ASP SER LEU ASN LEU ASP          
SEQRES   9 h  146  SER LEU LEU VAL ASP GLN LYS GLN LEU ASN SER LEU ARG          
SEQRES  10 h  146  ARG SER GLY GLN ILE ALA ASN ASP PRO SER LYS LYS ARG          
SEQRES  11 h  146  ARG ARG ASP PHE GLY ALA PRO ALA ASN LYS ARG PRO ARG          
SEQRES  12 h  146  ARG GLY LEU                                                  
SEQRES   1 j  110  MET SER SER GLN ILE ILE ASP ARG PRO LYS HIS GLU LEU          
SEQRES   2 j  110  SER ARG ALA GLU LEU GLU GLU LEU GLU GLU PHE GLU PHE          
SEQRES   3 j  110  LYS HIS GLY PRO MET SER LEU ILE ASN ASP ALA MET VAL          
SEQRES   4 j  110  THR ARG THR PRO VAL ILE ILE SER LEU ARG ASN ASN HIS          
SEQRES   5 j  110  LYS ILE ILE ALA ARG VAL LYS ALA PHE ASP ARG HIS CYS          
SEQRES   6 j  110  ASN MET VAL LEU GLU ASN VAL LYS GLU LEU TRP THR GLU          
SEQRES   7 j  110  LYS LYS GLY LYS ASN VAL ILE ASN ARG GLU ARG PHE ILE          
SEQRES   8 j  110  SER LYS LEU PHE LEU ARG GLY ASP SER VAL ILE VAL VAL          
SEQRES   9 j  110  LEU LYS THR PRO VAL GLU                                      
SEQRES   1 U  214    A   A   G   C   A   G   C   U   U   U   A   C   A          
SEQRES   2 U  214    G   A   U   C   A   A   U   G   G   C   G   G   A          
SEQRES   3 U  214    G   G   G   A   G   G   U   C   A   A   C   A   U          
SEQRES   4 U  214    C   A   A   G   A   A   C   U   G   U   G   G   G          
SEQRES   5 U  214    C   C   U   U   U   U   A   U   U   G   C   C   U          
SEQRES   6 U  214    A   U   A   G   A   A   C   U   U   A   U   A   A          
SEQRES   7 U  214    C   G   A   A   C   A   U   G   G   U   U   C   U          
SEQRES   8 U  214    U   G   C   C   U   U   U   U   A   C   C   A   G          
SEQRES   9 U  214    A   A   C   C   A   U   C   C   G   G   G   U   G          
SEQRES  10 U  214    U   U   G   U   C   U   C   C   A   U   A   G   A          
SEQRES  11 U  214    A   A   C   A   G   G   U   A   A   A   G   C   U          
SEQRES  12 U  214    G   U   C   C   G   U   U   A   C   U   G   U   G          
SEQRES  13 U  214    G   G   C   U   U   G   C   C   A   U   A   U   U          
SEQRES  14 U  214    U   U   U   U   G   G   A   A   C   U   U   U   U          
SEQRES  15 U  214    C   U   G   C   C   C   U   U   U   U   U   C   U          
SEQRES  16 U  214    C   A   A   U   G   A   G   U   A   A   G   G   A          
SEQRES  17 U  214    G   G   G   C   G   U                                      
SEQRES   1 K  126  MET SER ALA PRO ASN PRO LYS ALA PHE PRO LEU ALA ASP          
SEQRES   2 K  126  ALA ALA LEU THR GLN GLN ILE LEU ASP VAL VAL GLN GLN          
SEQRES   3 K  126  ALA ALA ASN LEU ARG GLN LEU LYS LYS GLY ALA ASN GLU          
SEQRES   4 K  126  ALA THR LYS THR LEU ASN ARG GLY ILE SER GLU PHE ILE          
SEQRES   5 K  126  ILE MET ALA ALA ASP CYS GLU PRO ILE GLU ILE LEU LEU          
SEQRES   6 K  126  HIS LEU PRO LEU LEU CYS GLU ASP LYS ASN VAL PRO TYR          
SEQRES   7 K  126  VAL PHE VAL PRO SER ARG VAL ALA LEU GLY ARG ALA CYS          
SEQRES   8 K  126  GLY VAL SER ARG PRO VAL ILE ALA ALA SER ILE THR THR          
SEQRES   9 K  126  ASN ASP ALA SER ALA ILE LYS THR GLN ILE TYR ALA VAL          
SEQRES  10 K  126  LYS ASP LYS ILE GLU THR LEU LEU ILE                          
SEQRES   1 2   95  MET LEU PHE PHE SER PHE PHE LYS THR LEU VAL ASP GLN          
SEQRES   2 2   95  GLU VAL VAL VAL GLU LEU LYS ASN ASP ILE GLU ILE LYS          
SEQRES   3 2   95  GLY THR LEU GLN SER VAL ASP GLN PHE LEU ASN LEU LYS          
SEQRES   4 2   95  LEU ASP ASN ILE SER CYS THR ASP GLU LYS LYS TYR PRO          
SEQRES   5 2   95  HIS LEU GLY SER VAL ARG ASN ILE PHE ILE ARG GLY SER          
SEQRES   6 2   95  THR VAL ARG TYR VAL TYR LEU ASN LYS ASN MET VAL ASP          
SEQRES   7 2   95  THR ASN LEU LEU GLN ASP ALA THR ARG ARG GLU VAL MET          
SEQRES   8 2   95  THR GLU ARG LYS                                              
SEQRES   1 3   89  MET GLU THR PRO LEU ASP LEU LEU LYS LEU ASN LEU ASP          
SEQRES   2 3   89  GLU ARG VAL TYR ILE LYS LEU ARG GLY ALA ARG THR LEU          
SEQRES   3 3   89  VAL GLY THR LEU GLN ALA PHE ASP SER HIS CYS ASN ILE          
SEQRES   4 3   89  VAL LEU SER ASP ALA VAL GLU THR ILE TYR GLN LEU ASN          
SEQRES   5 3   89  ASN GLU GLU LEU SER GLU SER GLU ARG ARG CYS GLU MET          
SEQRES   6 3   89  VAL PHE ILE ARG GLY ASP THR VAL THR LEU ILE SER THR          
SEQRES   7 3   89  PRO SER GLU ASP ASP ASP GLY ALA VAL GLU ILE                  
SEQRES   1 4  187  MET LEU PRO LEU TYR LEU LEU THR ASN ALA LYS GLY GLN          
SEQRES   2 4  187  GLN MET GLN ILE GLU LEU LYS ASN GLY GLU ILE ILE GLN          
SEQRES   3 4  187  GLY ILE LEU THR ASN VAL ASP ASN TRP MET ASN LEU THR          
SEQRES   4 4  187  LEU SER ASN VAL THR GLU TYR SER GLU GLU SER ALA ILE          
SEQRES   5 4  187  ASN SER GLU ASP ASN ALA GLU SER SER LYS ALA VAL LYS          
SEQRES   6 4  187  LEU ASN GLU ILE TYR ILE ARG GLY THR PHE ILE LYS PHE          
SEQRES   7 4  187  ILE LYS LEU GLN ASP ASN ILE ILE ASP LYS VAL LYS GLN          
SEQRES   8 4  187  GLN ILE ASN SER ASN ASN ASN SER ASN SER ASN GLY PRO          
SEQRES   9 4  187  GLY HIS LYS ARG TYR TYR ASN ASN ARG ASP SER ASN ASN          
SEQRES  10 4  187  ASN ARG GLY ASN TYR ASN ARG ARG ASN ASN ASN ASN GLY          
SEQRES  11 4  187  ASN SER ASN ARG ARG PRO TYR SER GLN ASN ARG GLN TYR          
SEQRES  12 4  187  ASN ASN SER ASN SER SER ASN ILE ASN ASN SER ILE ASN          
SEQRES  13 4  187  SER ILE ASN SER ASN ASN GLN ASN MET ASN ASN GLY LEU          
SEQRES  14 4  187  GLY GLY SER VAL GLN HIS HIS PHE ASN SER SER SER PRO          
SEQRES  15 4  187  GLN LYS VAL GLU PHE                                          
SEQRES   1 5   93  MET SER LEU PRO GLU ILE LEU PRO LEU GLU VAL ILE ASP          
SEQRES   2 5   93  LYS THR ILE ASN GLN LYS VAL LEU ILE VAL LEU GLN SER          
SEQRES   3 5   93  ASN ARG GLU PHE GLU GLY THR LEU VAL GLY PHE ASP ASP          
SEQRES   4 5   93  PHE VAL ASN VAL ILE LEU GLU ASP ALA VAL GLU TRP LEU          
SEQRES   5 5   93  ILE ASP PRO GLU ASP GLU SER ARG ASN GLU LYS VAL MET          
SEQRES   6 5   93  GLN HIS HIS GLY ARG MET LEU LEU SER GLY ASN ASN ILE          
SEQRES   7 5   93  ALA ILE LEU VAL PRO GLY GLY LYS LYS THR PRO THR GLU          
SEQRES   8 5   93  ALA LEU                                                      
SEQRES   1 6   86  MET SER GLY LYS ALA SER THR GLU GLY SER VAL THR THR          
SEQRES   2 6   86  GLU PHE LEU SER ASP ILE ILE GLY LYS THR VAL ASN VAL          
SEQRES   3 6   86  LYS LEU ALA SER GLY LEU LEU TYR SER GLY ARG LEU GLU          
SEQRES   4 6   86  SER ILE ASP GLY PHE MET ASN VAL ALA LEU SER SER ALA          
SEQRES   5 6   86  THR GLU HIS TYR GLU SER ASN ASN ASN LYS LEU LEU ASN          
SEQRES   6 6   86  LYS PHE ASN SER ASP VAL PHE LEU ARG GLY THR GLN VAL          
SEQRES   7 6   86  MET TYR ILE SER GLU GLN LYS ILE                              
SEQRES   1 7  115  MET HIS GLN GLN HIS SER LYS SER GLU ASN LYS PRO GLN          
SEQRES   2 7  115  GLN GLN ARG LYS LYS PHE GLU GLY PRO LYS ARG GLU ALA          
SEQRES   3 7  115  ILE LEU ASP LEU ALA LYS TYR LYS ASP SER LYS ILE ARG          
SEQRES   4 7  115  VAL LYS LEU MET GLY GLY LYS LEU VAL ILE GLY VAL LEU          
SEQRES   5 7  115  LYS GLY TYR ASP GLN LEU MET ASN LEU VAL LEU ASP ASP          
SEQRES   6 7  115  THR VAL GLU TYR MET SER ASN PRO ASP ASP GLU ASN ASN          
SEQRES   7 7  115  THR GLU LEU ILE SER LYS ASN ALA ARG LYS LEU GLY LEU          
SEQRES   8 7  115  THR VAL ILE ARG GLY THR ILE LEU VAL SER LEU SER SER          
SEQRES   9 7  115  ALA GLU GLY SER ASP VAL LEU TYR MET GLN LYS                  
SEQRES   1 8  109  MET SER ALA THR LEU LYS ASP TYR LEU ASN LYS ARG VAL          
SEQRES   2 8  109  VAL ILE ILE LYS VAL ASP GLY GLU CYS LEU ILE ALA SER          
SEQRES   3 8  109  LEU ASN GLY PHE ASP LYS ASN THR ASN LEU PHE ILE THR          
SEQRES   4 8  109  ASN VAL PHE ASN ARG ILE SER LYS GLU PHE ILE CYS LYS          
SEQRES   5 8  109  ALA GLN LEU LEU ARG GLY SER GLU ILE ALA LEU VAL GLY          
SEQRES   6 8  109  LEU ILE ASP ALA GLU ASN ASP ASP SER LEU ALA PRO ILE          
SEQRES   7 8  109  ASP GLU LYS LYS VAL PRO MET LEU LYS ASP THR LYS ASN          
SEQRES   8 8  109  LYS ILE GLU ASN GLU HIS VAL ILE TRP GLU LYS VAL TYR          
SEQRES   9 8  109  GLU SER LYS THR LYS                                          
SEQRES   1 C 1008  MET GLU GLY ASP ASP LEU PHE ASP GLU PHE GLY ASN LEU          
SEQRES   2 C 1008  ILE GLY VAL ASP PRO PHE ASP SER ASP GLU GLU GLU SER          
SEQRES   3 C 1008  VAL LEU ASP GLU GLN GLU GLN TYR GLN THR ASN THR PHE          
SEQRES   4 C 1008  GLU GLY SER GLY ASN ASN ASN GLU ILE GLU SER ARG GLN          
SEQRES   5 C 1008  LEU THR SER LEU GLY SER LYS LYS GLU LEU GLY ILE SER          
SEQRES   6 C 1008  LEU GLU HIS PRO TYR GLY LYS GLU VAL GLU VAL LEU MET          
SEQRES   7 C 1008  GLU THR LYS ASN THR GLN SER PRO GLN THR PRO LEU VAL          
SEQRES   8 C 1008  GLU PRO VAL THR GLU ARG THR LYS LEU GLN GLU HIS THR          
SEQRES   9 C 1008  ILE PHE THR GLN LEU LYS LYS ASN ILE PRO LYS THR ARG          
SEQRES  10 C 1008  TYR ASN ARG ASP TYR MET LEU SER MET ALA ASN ILE PRO          
SEQRES  11 C 1008  GLU ARG ILE ILE ASN VAL GLY VAL ILE GLY PRO LEU HIS          
SEQRES  12 C 1008  SER GLY LYS THR SER LEU MET ASP LEU LEU VAL ILE ASP          
SEQRES  13 C 1008  SER HIS LYS ARG ILE PRO ASP MET SER LYS ASN VAL GLU          
SEQRES  14 C 1008  LEU GLY TRP LYS PRO LEU ARG TYR LEU ASP ASN LEU LYS          
SEQRES  15 C 1008  GLN GLU ILE ASP ARG GLY LEU SER ILE LYS LEU ASN GLY          
SEQRES  16 C 1008  SER THR LEU LEU CYS THR ASP LEU GLU SER LYS SER ARG          
SEQRES  17 C 1008  MET ILE ASN PHE LEU ASP ALA PRO GLY HIS VAL ASN PHE          
SEQRES  18 C 1008  MET ASP GLU THR ALA VAL ALA LEU ALA ALA SER ASP LEU          
SEQRES  19 C 1008  VAL LEU ILE VAL ILE ASP VAL VAL GLU GLY VAL THR PHE          
SEQRES  20 C 1008  VAL VAL GLU GLN LEU ILE LYS GLN SER ILE LYS ASN ASN          
SEQRES  21 C 1008  VAL ALA MET CYS PHE VAL ILE ASN LYS LEU ASP ARG LEU          
SEQRES  22 C 1008  ILE LEU ASP LEU LYS LEU PRO PRO MET ASP ALA TYR LEU          
SEQRES  23 C 1008  LYS LEU ASN HIS ILE ILE ALA ASN ILE ASN SER PHE THR          
SEQRES  24 C 1008  LYS GLY ASN VAL PHE SER PRO ILE ASP ASN ASN ILE ILE          
SEQRES  25 C 1008  PHE ALA SER THR LYS LEU GLY PHE THR PHE THR ILE LYS          
SEQRES  26 C 1008  GLU PHE VAL SER TYR TYR TYR ALA HIS SER ILE PRO SER          
SEQRES  27 C 1008  SER LYS ILE ASP ASP PHE THR THR ARG LEU TRP GLY SER          
SEQRES  28 C 1008  VAL TYR TYR HIS LYS GLY ASN PHE ARG THR LYS PRO PHE          
SEQRES  29 C 1008  GLU ASN VAL GLU LYS TYR PRO THR PHE VAL GLU PHE ILE          
SEQRES  30 C 1008  LEU ILE PRO LEU TYR LYS ILE PHE SER TYR ALA LEU SER          
SEQRES  31 C 1008  MET GLU LYS ASP LYS LEU LYS ASN LEU LEU ARG SER ASN          
SEQRES  32 C 1008  PHE ARG VAL ASN LEU SER GLN GLU ALA LEU GLN TYR ASP          
SEQRES  33 C 1008  PRO GLN PRO PHE LEU LYS HIS VAL LEU GLN LEU ILE PHE          
SEQRES  34 C 1008  ARG GLN GLN THR GLY LEU VAL ASP ALA ILE THR ARG CYS          
SEQRES  35 C 1008  TYR GLN PRO PHE GLU LEU PHE ASP ASN LYS THR ALA HIS          
SEQRES  36 C 1008  LEU SER ILE PRO GLY LYS SER THR PRO GLU GLY THR LEU          
SEQRES  37 C 1008  TRP ALA HIS VAL LEU LYS THR VAL ASP TYR GLY GLY ALA          
SEQRES  38 C 1008  GLU TRP SER LEU VAL ARG ILE TYR SER GLY LEU LEU LYS          
SEQRES  39 C 1008  ARG GLY ASP THR VAL ARG ILE LEU ASP THR SER GLN SER          
SEQRES  40 C 1008  GLU SER ARG GLN LYS ARG GLN LEU HIS ASP ILE SER LYS          
SEQRES  41 C 1008  THR GLU THR SER ASN GLU ASP GLU ASP SER LYS THR GLU          
SEQRES  42 C 1008  THR PRO SER CYS GLU VAL GLU GLU ILE GLY LEU LEU GLY          
SEQRES  43 C 1008  GLY ARG TYR VAL TYR PRO VAL HIS GLU ALA HIS LYS GLY          
SEQRES  44 C 1008  GLN ILE VAL LEU ILE LYS GLY ILE SER SER ALA TYR ILE          
SEQRES  45 C 1008  LYS SER ALA THR LEU TYR SER VAL LYS SER LYS GLU ASP          
SEQRES  46 C 1008  MET LYS GLN LEU LYS PHE PHE LYS PRO LEU ASP TYR ILE          
SEQRES  47 C 1008  THR GLU ALA VAL PHE LYS ILE VAL LEU GLN PRO LEU LEU          
SEQRES  48 C 1008  PRO ARG GLU LEU PRO LYS LEU LEU ASP ALA LEU ASN LYS          
SEQRES  49 C 1008  ILE SER LYS TYR TYR PRO GLY VAL ILE ILE LYS VAL GLU          
SEQRES  50 C 1008  GLU SER GLY GLU HIS VAL ILE LEU GLY ASN GLY GLU LEU          
SEQRES  51 C 1008  TYR MET ASP CYS LEU LEU TYR ASP LEU ARG ALA SER TYR          
SEQRES  52 C 1008  ALA LYS ILE GLU ILE LYS ILE SER ASP PRO LEU THR VAL          
SEQRES  53 C 1008  PHE SER GLU SER CYS SER ASN GLU SER PHE ALA SER ILE          
SEQRES  54 C 1008  PRO VAL SER ASN SER ILE SER ARG LEU GLY GLU GLU ASN          
SEQRES  55 C 1008  LEU PRO GLY LEU SER ILE SER VAL ALA ALA GLU PRO MET          
SEQRES  56 C 1008  ASP SER LYS MET ILE GLN ASP LEU SER ARG ASN THR LEU          
SEQRES  57 C 1008  GLY LYS GLY GLN ASN CYS LEU ASP ILE ASP GLY ILE MET          
SEQRES  58 C 1008  ASP ASN PRO ARG LYS LEU SER LYS ILE LEU ARG THR GLU          
SEQRES  59 C 1008  TYR GLY TRP ASP SER LEU ALA SER ARG ASN VAL TRP SER          
SEQRES  60 C 1008  PHE TYR ASN GLY ASN VAL LEU ILE ASN ASP THR LEU PRO          
SEQRES  61 C 1008  ASP GLU ILE SER PRO GLU LEU LEU SER LYS TYR LYS GLU          
SEQRES  62 C 1008  GLN ILE ILE GLN GLY PHE TYR TRP ALA VAL LYS GLU GLY          
SEQRES  63 C 1008  PRO LEU ALA GLU GLU PRO ILE TYR GLY VAL GLN TYR LYS          
SEQRES  64 C 1008  LEU LEU SER ILE SER VAL PRO SER ASP VAL ASN ILE ASP          
SEQRES  65 C 1008  VAL MET LYS SER GLN ILE ILE PRO LEU MET LYS LYS ALA          
SEQRES  66 C 1008  CYS TYR VAL GLY LEU LEU THR ALA ILE PRO ILE LEU LEU          
SEQRES  67 C 1008  GLU PRO ILE TYR GLU VAL ASP ILE THR VAL HIS ALA PRO          
SEQRES  68 C 1008  LEU LEU PRO ILE VAL GLU GLU LEU MET LYS LYS ARG ARG          
SEQRES  69 C 1008  GLY SER ARG ILE TYR LYS THR ILE LYS VAL ALA GLY THR          
SEQRES  70 C 1008  PRO LEU LEU GLU VAL ARG GLY GLN VAL PRO VAL ILE GLU          
SEQRES  71 C 1008  SER ALA GLY PHE GLU THR ASP LEU ARG LEU SER THR ASN          
SEQRES  72 C 1008  GLY LEU GLY MET CYS GLN LEU TYR PHE TRP HIS LYS ILE          
SEQRES  73 C 1008  TRP ARG LYS VAL PRO GLY ASP VAL LEU ASP LYS ASP ALA          
SEQRES  74 C 1008  PHE ILE PRO LYS LEU LYS PRO ALA PRO ILE ASN SER LEU          
SEQRES  75 C 1008  SER ARG ASP PHE VAL MET LYS THR ARG ARG ARG LYS GLY          
SEQRES  76 C 1008  ILE SER THR GLY GLY PHE MET SER ASN ASP GLY PRO THR          
SEQRES  77 C 1008  LEU GLU LYS TYR ILE SER ALA GLU LEU TYR ALA GLN LEU          
SEQRES  78 C 1008  ARG GLU ASN GLY LEU VAL PRO                                  
HET    GTP  C1101      32                                                       
HETNAM     GTP GUANOSINE-5'-TRIPHOSPHATE                                        
FORMUL  36  GTP    C10 H16 N5 O14 P3                                            
HELIX    1 AA1 LYS A  110  ARG A  124  1                                  15    
HELIX    2 AA2 PRO A  135  ALA A  150  1                                  16    
HELIX    3 AA3 LYS A  158  LYS A  166  1                                   9    
HELIX    4 AA4 TYR A  167  ASN A  178  1                                  12    
HELIX    5 AA5 ILE A  209  ARG A  231  1                                  23    
HELIX    6 AA6 TYR A  251  GLU A  256  1                                   6    
HELIX    7 AA7 ASP A  304  THR A  316  1                                  13    
HELIX    8 AA8 ASP A  324  TYR A  329  5                                   6    
HELIX    9 AA9 ASP A  332  LEU A  342  1                                  11    
HELIX   10 AB1 ARG A  380  PHE A  387  1                                   8    
HELIX   11 AB2 ASN A  472  SER A  482  1                                  11    
HELIX   12 AB3 PRO A  483  ARG A  488  1                                   6    
HELIX   13 AB4 LEU A  501  GLN A  508  1                                   8    
HELIX   14 AB5 PRO A  515  HIS A  535  1                                  21    
HELIX   15 AB6 LYS A  544  LYS A  552  1                                   9    
HELIX   16 AB7 TRP A  564  LYS A  586  1                                  23    
HELIX   17 AB8 THR A  606  SER A  613  1                                   8    
HELIX   18 AB9 GLY A  616  LEU A  641  1                                  26    
HELIX   19 AC1 ASP A  645  HIS A  659  1                                  15    
HELIX   20 AC2 HIS A  659  THR A  664  1                                   6    
HELIX   21 AC3 TYR A  671  ASN A  692  1                                  22    
HELIX   22 AC4 TRP A  704  THR A  731  1                                  28    
HELIX   23 AC5 TYR A  753  MET A  770  1                                  18    
HELIX   24 AC6 ILE A  774  ASN A  796  1                                  23    
HELIX   25 AC7 PRO A  805  GLY A  837  1                                  33    
HELIX   26 AC8 THR A  843  GLY A  871  1                                  29    
HELIX   27 AC9 THR A  875  SER A  894  1                                  20    
HELIX   28 AD1 ASN A  907  LYS A  926  1                                  20    
HELIX   29 AD2 ASN A  930  ASN A  946  1                                  17    
HELIX   30 AD3 ASN A  946  THR A  960  1                                  15    
HELIX   31 AD4 ASP A  985  LYS A 1007  1                                  23    
HELIX   32 AD5 ILE A 1020  ASN A 1034  1                                  15    
HELIX   33 AD6 MET A 1057  ILE A 1061  5                                   5    
HELIX   34 AD7 ASP A 1062  LEU A 1072  1                                  11    
HELIX   35 AD8 ASP A 1075  ASN A 1087  1                                  13    
HELIX   36 AD9 PHE A 1109  GLY A 1136  1                                  28    
HELIX   37 AE1 SER A 1149  LYS A 1154  1                                   6    
HELIX   38 AE2 GLU A 1176  ASN A 1190  1                                  15    
HELIX   39 AE3 PRO A 1208  ARG A 1212  5                                   5    
HELIX   40 AE4 ILE A 1216  VAL A 1234  1                                  19    
HELIX   41 AE5 GLN A 1273  MET A 1275  5                                   3    
HELIX   42 AE6 SER A 1305  MET A 1321  1                                  17    
HELIX   43 AE7 THR A 1327  ARG A 1347  1                                  21    
HELIX   44 AE8 ARG A 1347  THR A 1353  1                                   7    
HELIX   45 AE9 THR A 1353  ASN A 1376  1                                  24    
HELIX   46 AF1 PRO A 1385  THR A 1390  1                                   6    
HELIX   47 AF2 PRO A 1391  GLY A 1395  5                                   5    
HELIX   48 AF3 ALA A 1409  SER A 1413  5                                   5    
HELIX   49 AF4 THR A 1439  TYR A 1443  5                                   5    
HELIX   50 AF5 THR A 1446  GLN A 1471  1                                  26    
HELIX   51 AF6 ARG A 1490  PHE A 1495  1                                   6    
HELIX   52 AF7 ASP A 1498  ALA A 1503  1                                   6    
HELIX   53 AF8 GLY A 1507  PHE A 1514  1                                   8    
HELIX   54 AF9 LYS A 1515  SER A 1518  5                                   4    
HELIX   55 AG1 ASN A 1529  GLY A 1534  1                                   6    
HELIX   56 AG2 LEU A 1539  LEU A 1550  1                                  12    
HELIX   57 AG3 GLY A 1551  THR A 1560  1                                  10    
HELIX   58 AG4 LEU A 1561  GLY A 1566  5                                   6    
HELIX   59 AG5 LYS A 1577  GLN A 1586  1                                  10    
HELIX   60 AG6 THR A 1591  ILE A 1601  1                                  11    
HELIX   61 AG7 PRO A 1602  SER A 1611  1                                  10    
HELIX   62 AG8 PRO A 1612  ILE A 1614  5                                   3    
HELIX   63 AG9 ILE A 1638  PHE A 1649  1                                  12    
HELIX   64 AH1 HIS A 1652  GLU A 1672  1                                  21    
HELIX   65 AH2 LEU A 1673  LEU A 1676  5                                   4    
HELIX   66 AH3 HIS A 1687  TYR A 1692  5                                   6    
HELIX   67 AH4 ASP A 1742  HIS A 1746  5                                   5    
HELIX   68 AH5 ASP A 1747  ASP A 1762  1                                  16    
HELIX   69 AH6 GLY A 1793  ASN A 1809  1                                  17    
HELIX   70 AH7 ASN A 1809  GLN A 1824  1                                  16    
HELIX   71 AH8 SER A 1837  ASN A 1845  5                                   9    
HELIX   72 AH9 HIS A 1895  ALA A 1900  5                                   6    
HELIX   73 AI1 ARG A 1904  LEU A 1924  1                                  21    
HELIX   74 AI2 ARG A 1937  ALA A 1939  5                                   3    
HELIX   75 AI3 MET A 1940  HIS A 1947  1                                   8    
HELIX   76 AI4 LEU A 1963  MET A 1969  5                                   7    
HELIX   77 AI5 ILE A 1971  LYS A 1980  1                                  10    
HELIX   78 AI6 SER A 2000  ASN A 2018  1                                  19    
HELIX   79 AI7 ASN A 2018  LEU A 2027  1                                  10    
HELIX   80 AI8 THR A 2044  ASN A 2068  1                                  25    
HELIX   81 AI9 LEU A 2074  LEU A 2084  1                                  11    
HELIX   82 AJ1 SER A 2092  ALA A 2104  1                                  13    
HELIX   83 AJ2 SER A 2148  ASN A 2159  1                                  12    
HELIX   84 AJ3 THR A 2160  LYS A 2167  5                                   8    
HELIX   85 AJ4 LYS A 2187  SER A 2197  1                                  11    
HELIX   86 AJ5 ALA A 2270  PHE A 2281  1                                  12    
HELIX   87 AJ6 THR A 2308  ASN A 2318  1                                  11    
HELIX   88 AJ7 ASN A 2323  GLU A 2330  1                                   8    
HELIX   89 AJ8 ARG A 2388  GLU A 2397  1                                  10    
HELIX   90 AJ9 THR H  114  PHE H  146  1                                  33    
HELIX   91 AK1 ASN H  147  ASN H  164  1                                  18    
HELIX   92 AK2 LEU J  159  LEU J  170  1                                  12    
HELIX   93 AK3 GLN J  171  ASN J  177  1                                   7    
HELIX   94 AK4 SER J  186  THR J  198  1                                  13    
HELIX   95 AK5 ASP J  206  ASP J  210  5                                   5    
HELIX   96 AK6 THR J  219  ALA J  236  1                                  18    
HELIX   97 AK7 PRO J  241  ARG J  255  1                                  15    
HELIX   98 AK8 SER J  258  CYS J  271  1                                  14    
HELIX   99 AK9 SER J  274  HIS J  285  1                                  12    
HELIX  100 AL1 VAL J  289  ASN J  303  1                                  15    
HELIX  101 AL2 SER J  306  GLU J  317  1                                  12    
HELIX  102 AL3 THR J  319  ILE J  334  1                                  16    
HELIX  103 AL4 ASP J  337  GLU J  348  1                                  12    
HELIX  104 AL5 LYS J  351  ILE J  365  1                                  15    
HELIX  105 AL6 SER J  368  SER J  380  1                                  13    
HELIX  106 AL7 TYR J  381  LEU J  395  1                                  15    
HELIX  107 AL8 ILE J  401  GLU J  410  1                                  10    
HELIX  108 AL9 LEU J  421  ASN J  435  1                                  15    
HELIX  109 AM1 SER J  442  ALA J  454  1                                  13    
HELIX  110 AM2 SER J  457  GLY J  476  1                                  20    
HELIX  111 AM3 GLU J  479  LYS J  491  1                                  13    
HELIX  112 AM4 SER J  495  ASP J  509  1                                  15    
HELIX  113 AM5 CYS J  511  TYR J  526  1                                  16    
HELIX  114 AM6 GLU J  531  THR J  543  1                                  13    
HELIX  115 AM7 ASP J  548  SER J  557  1                                  10    
HELIX  116 AM8 GLY J  559  GLN J  572  1                                  14    
HELIX  117 AM9 THR J  576  PHE J  589  1                                  14    
HELIX  118 AN1 ASN J  593  LEU J  608  1                                  16    
HELIX  119 AN2 GLN J  609  LEU J  624  1                                  16    
HELIX  120 AN3 GLU J  625  PHE J  627  5                                   3    
HELIX  121 AN4 GLU J  633  ASN J  649  1                                  17    
HELIX  122 AN5 GLU J  650  PHE J  664  1                                  15    
HELIX  123 AN6 CYS J  667  MET J  681  1                                  15    
HELIX  124 AN7 ASN J  683  VAL J  698  1                                  16    
HELIX  125 AN8 CYS J  701  ASP J  715  1                                  15    
HELIX  126 AN9 ASN J  718  ASN J  733  1                                  16    
HELIX  127 AO1 ASP J  736  LEU J  750  1                                  15    
HELIX  128 AO2 LEU J  753  PHE J  767  1                                  15    
HELIX  129 AO3 ASN J  770  GLY J  784  1                                  15    
HELIX  130 AO4 LEU J  789  THR J  801  1                                  13    
HELIX  131 AO5 ASP J  804  ALA J  819  1                                  16    
HELIX  132 AO6 GLN J  820  CYS J  835  1                                  16    
HELIX  133 AO7 GLY J  839  LEU J  852  1                                  14    
HELIX  134 AO8 THR J  856  PHE J  863  1                                   8    
HELIX  135 AO9 GLY J  871  ASN J  880  1                                  10    
HELIX  136 AP1 ARG J  889  ASP J  898  1                                  10    
HELIX  137 AP2 THR D   11  GLU D   22  1                                  12    
HELIX  138 AP3 ASP D   36  ARG D   54  1                                  19    
HELIX  139 AP4 ASP D  109  ASN D  127  1                                  19    
HELIX  140 AP5 ILE F   46  ALA F   58  1                                  13    
HELIX  141 AP6 ARG F   64  VAL F   78  1                                  15    
HELIX  142 AP7 ASP F   79  GLN F   87  1                                   9    
HELIX  143 AP8 PRO F   96  SER F  121  1                                  26    
HELIX  144 AP9 GLU F  126  ILE F  131  1                                   6    
HELIX  145 AQ1 SER F  133  GLU F  147  1                                  15    
HELIX  146 AQ2 ASP F  155  LYS F  164  1                                  10    
HELIX  147 AQ3 THR F  168  SER F  182  1                                  15    
HELIX  148 AQ4 ASP F  190  ALA F  226  1                                  37    
HELIX  149 AQ5 ALA F  226  VAL F  233  1                                   8    
HELIX  150 AQ6 GLY F  234  GLY F  246  1                                  13    
HELIX  151 AQ7 GLY F  247  ILE F  254  1                                   8    
HELIX  152 AQ8 PRO F  255  ALA F  260  1                                   6    
HELIX  153 AQ9 GLU F  282  ALA F  287  1                                   6    
HELIX  154 AR1 SER F  288  LYS F  293  1                                   6    
HELIX  155 AR2 VAL F  298  GLN F  320  1                                  23    
HELIX  156 AR3 VAL F  328  GLU F  346  1                                  19    
HELIX  157 AR4 GLY F  369  ARG F  380  1                                  12    
HELIX  158 AR5 SER F  382  ASN F  389  1                                   8    
HELIX  159 AR6 THR F  415  GLY F  422  1                                   8    
HELIX  160 AR7 THR F  438  ILE F  457  1                                  20    
HELIX  161 AR8 LEU G  151  HIS G  164  1                                  14    
HELIX  162 AR9 LYS G  177  THR G  189  1                                  13    
HELIX  163 AS1 GLU G  193  GLU G  198  1                                   6    
HELIX  164 AS2 THR G  237  LYS G  259  1                                  23    
HELIX  165 AS3 ASN G  276  VAL G  280  5                                   5    
HELIX  166 AS4 ASP G  289  ASN G  330  1                                  42    
HELIX  167 AS5 ASN G  349  LEU G  363  1                                  15    
HELIX  168 AS6 ASN G  385  LYS G  398  1                                  14    
HELIX  169 AS7 ASP G  447  GLY G  456  1                                  10    
HELIX  170 AS8 GLN G  457  ASP G  459  5                                   3    
HELIX  171 AS9 LYS B  364  ILE B  370  1                                   7    
HELIX  172 AT1 LEU B  373  GLN B  388  1                                  16    
HELIX  173 AT2 ARG B  399  GLN B  407  1                                   9    
HELIX  174 AT3 ARG B  415  ILE B  423  1                                   9    
HELIX  175 AT4 PRO B  425  LYS B  433  1                                   9    
HELIX  176 AT5 ASP B  485  ALA B  490  5                                   6    
HELIX  177 AT6 ILE B  502  GLY B  513  1                                  12    
HELIX  178 AT7 GLY B  526  TYR B  543  1                                  18    
HELIX  179 AT8 LEU B  563  LEU B  578  1                                  16    
HELIX  180 AT9 LYS B  597  THR B  602  1                                   6    
HELIX  181 AU1 THR B  608  ASN B  618  1                                  11    
HELIX  182 AU2 SER B  619  ASN B  621  5                                   3    
HELIX  183 AU3 LEU B  622  LEU B  627  1                                   6    
HELIX  184 AU4 GLU B  635  ASP B  641  5                                   7    
HELIX  185 AU5 ARG B  643  ALA B  657  1                                  15    
HELIX  186 AU6 ASN B  676  LEU B  684  1                                   9    
HELIX  187 AU7 ASP B  695  ARG B  699  5                                   5    
HELIX  188 AU8 ASN B  714  ASN B  735  1                                  22    
HELIX  189 AU9 SER B  746  ASN B  765  1                                  20    
HELIX  190 AV1 GLY B  776  GLU B  784  1                                   9    
HELIX  191 AV2 LEU B  793  GLY B  800  1                                   8    
HELIX  192 AV3 THR B  809  ASP B  822  1                                  14    
HELIX  193 AV4 ALA B  832  VAL B  838  1                                   7    
HELIX  194 AV5 SER B  864  ARG B  874  1                                  11    
HELIX  195 AV6 ASP B  891  ASN B  903  1                                  13    
HELIX  196 AV7 GLN B  911  GLY B  927  1                                  17    
HELIX  197 AV8 CYS B  931  TYR B  941  1                                  11    
HELIX  198 AV9 THR B  942  SER B  951  1                                  10    
HELIX  199 AW1 ASP B  959  GLY B  964  1                                   6    
HELIX  200 AW2 LYS B  968  GLN B  984  1                                  17    
HELIX  201 AW3 THR B  999  TYR B 1009  1                                  11    
HELIX  202 AW4 ASN B 1011  LEU B 1022  1                                  12    
HELIX  203 AW5 THR B 1027  SER B 1038  1                                  12    
HELIX  204 AW6 GLU B 1039  LYS B 1042  5                                   4    
HELIX  205 AW7 GLU B 1050  ALA B 1061  1                                  12    
HELIX  206 AW8 ASP B 1071  SER B 1085  1                                  15    
HELIX  207 AW9 GLY B 1091  GLY B 1120  1                                  30    
HELIX  208 AX1 TRP B 1121  LYS B 1138  1                                  18    
HELIX  209 AX2 PRO B 1153  SER B 1163  1                                  11    
HELIX  210 AX3 PRO B 1166  LEU B 1173  1                                   8    
HELIX  211 AX4 THR B 1175  ILE B 1183  1                                   9    
HELIX  212 AX5 TYR B 1188  ARG B 1198  1                                  11    
HELIX  213 AX6 LYS B 1277  ASN B 1283  1                                   7    
HELIX  214 AX7 ASN B 1336  VAL B 1342  5                                   7    
HELIX  215 AX8 ASN B 1349  ASN B 1361  1                                  13    
HELIX  216 AX9 GLY B 1375  GLN B 1390  1                                  16    
HELIX  217 AY1 SER B 1401  LYS B 1414  1                                  14    
HELIX  218 AY2 ARG B 1415  ALA B 1420  1                                   6    
HELIX  219 AY3 ASP B 1431  SER B 1442  1                                  12    
HELIX  220 AY4 THR B 1448  ARG B 1457  1                                  10    
HELIX  221 AY5 ASP B 1475  GLN B 1481  5                                   7    
HELIX  222 AY6 VAL B 1483  GLU B 1503  1                                  21    
HELIX  223 AY7 ASN B 1517  ALA B 1525  1                                   9    
HELIX  224 AY8 SER B 1536  ARG B 1540  5                                   5    
HELIX  225 AY9 ASN B 1560  ASN B 1577  1                                  18    
HELIX  226 AZ1 SER B 1587  ILE B 1605  1                                  19    
HELIX  227 AZ2 GLN B 1616  ILE B 1621  1                                   6    
HELIX  228 AZ3 ASP B 1626  HIS B 1628  5                                   3    
HELIX  229 AZ4 LEU B 1629  LYS B 1634  1                                   6    
HELIX  230 AZ5 ALA B 1645  TYR B 1658  1                                  14    
HELIX  231 AZ6 LYS B 1668  ALA B 1672  5                                   5    
HELIX  232 AZ7 THR B 1699  VAL B 1707  1                                   9    
HELIX  233 AZ8 MET B 1728  LEU B 1736  1                                   9    
HELIX  234 AZ9 TYR B 1745  SER B 1761  1                                  17    
HELIX  235 BA1 GLN B 1767  TYR B 1775  1                                   9    
HELIX  236 BA2 SER B 1776  ILE B 1782  1                                   7    
HELIX  237 BA3 ASN B 1785  GLY B 1790  1                                   6    
HELIX  238 BA4 SER B 1795  VAL B 1815  1                                  21    
HELIX  239 BA5 LEU B 1847  GLY B 1857  1                                  11    
HELIX  240 BA6 SER B 1859  LEU B 1870  1                                  12    
HELIX  241 BA7 THR B 1875  THR B 1885  1                                  11    
HELIX  242 BA8 ALA B 1886  VAL B 1892  5                                   7    
HELIX  243 BA9 ASP B 1898  SER B 1906  1                                   9    
HELIX  244 BB1 LYS B 1907  LEU B 1909  5                                   3    
HELIX  245 BB2 SER B 1921  SER B 1935  1                                  15    
HELIX  246 BB3 PRO B 1940  GLY B 1969  1                                  30    
HELIX  247 BB4 ASN B 1972  GLY B 1986  1                                  15    
HELIX  248 BB5 PRO B 1993  ILE B 1997  5                                   5    
HELIX  249 BB6 ILE B 2004  GLU B 2010  1                                   7    
HELIX  250 BB7 VAL B 2016  LEU B 2022  1                                   7    
HELIX  251 BB8 GLU B 2023  LEU B 2031  1                                   9    
HELIX  252 BB9 THR B 2034  TYR B 2048  1                                  15    
HELIX  253 BC1 UNK x   21  UNK x   46  1                                  26    
HELIX  254 BC2 UNK x   53  UNK x   62  1                                  10    
HELIX  255 BC3 UNK x  102  UNK x  120  1                                  19    
HELIX  256 BC4 UNK x  202  UNK x  218  1                                  17    
HELIX  257 BC5 LEU l    3  LEU l   10  1                                   8    
HELIX  258 BC6 LEU l  106  ASN l  114  1                                   9    
HELIX  259 BC7 ALA m   16  LEU m   21  1                                   6    
HELIX  260 BC8 PHE m   24  GLY m   29  1                                   6    
HELIX  261 BC9 MET m   31  THR m   40  1                                  10    
HELIX  262 BD1 GLY n    5  ALA n   14  1                                  10    
HELIX  263 BD2 PRO p   12  GLN p   24  1                                  13    
HELIX  264 BD3 ASN q   14  LEU q   22  1                                   9    
HELIX  265 BD4 UNK E    6  UNK E   25  1                                  20    
HELIX  266 BD5 UNK E   41  UNK E   53  1                                  13    
HELIX  267 BD6 UNK E  152  UNK E  157  1                                   6    
HELIX  268 BD7 UNK E  158  UNK E  164  1                                   7    
HELIX  269 BD8 UNK E  184  UNK E  188  5                                   5    
HELIX  270 BD9 UNK E  189  UNK E  194  1                                   6    
HELIX  271 BE1 UNK E  214  UNK E  218  5                                   5    
HELIX  272 BE2 UNK E  219  UNK E  224  1                                   6    
HELIX  273 BE3 UNK E  354  UNK E  388  1                                  35    
HELIX  274 BE4 UNK E  396  UNK E  407  1                                  12    
HELIX  275 BE5 UNK E  495  UNK E  500  1                                   6    
HELIX  276 BE6 UNK E  503  UNK E  511  1                                   9    
HELIX  277 BE7 THR E  541  LYS E  560  1                                  20    
HELIX  278 BE8 LEU b   12  ILE b   16  5                                   5    
HELIX  279 BE9 PRO e   12  GLN e   24  1                                  13    
HELIX  280 BF1 GLY e   84  ILE e   87  5                                   4    
HELIX  281 BF2 ASN f   14  LEU f   22  1                                   9    
HELIX  282 BF3 GLY d    5  GLN d   15  1                                  11    
HELIX  283 BF4 ARG d   65  SER d   67  5                                   3    
HELIX  284 BF5 PRO d   75  ASN d   80  5                                   6    
HELIX  285 BF6 LYS h    2  LEU h   10  1                                   9    
HELIX  286 BF7 ASN h  102  VAL h  108  1                                   7    
HELIX  287 BF8 ALA j   16  GLY j   29  1                                  14    
HELIX  288 BF9 MET j   31  ARG j   41  1                                  11    
HELIX  289 BG1 ASP K   13  LEU K   30  1                                  18    
HELIX  290 BG2 GLY K   36  GLY K   47  1                                  12    
HELIX  291 BG3 PRO K   60  LEU K   64  5                                   5    
HELIX  292 BG4 HIS K   66  ASN K   75  1                                  10    
HELIX  293 BG5 SER K   83  GLY K   92  1                                  10    
HELIX  294 BG6 ILE K  110  ILE K  126  1                                  17    
HELIX  295 BG7 LEU 2    2  LEU 2   10  1                                   9    
HELIX  296 BG8 THR 2   79  GLU 2   89  1                                  11    
HELIX  297 BG9 PRO 3    4  LEU 3    8  1                                   5    
HELIX  298 BH1 LEU 4    2  ALA 4   10  1                                   9    
HELIX  299 BH2 ASN 4   84  LYS 4   90  1                                   7    
HELIX  300 BH3 LEU 5    7  THR 5   15  1                                   9    
HELIX  301 BH4 THR 6   12  ILE 6   19  1                                   8    
HELIX  302 BH5 HIS C  103  ASN C  112  1                                  10    
HELIX  303 BH6 ASN C  119  ILE C  129  1                                  11    
HELIX  304 BH7 GLY C  145  HIS C  158  1                                  14    
HELIX  305 BH8 SER C  165  GLY C  171  1                                   7    
HELIX  306 BH9 LEU C  181  GLY C  188  1                                   8    
HELIX  307 BI1 HIS C  218  ASN C  220  5                                   3    
HELIX  308 BI2 PHE C  221  SER C  232  1                                  12    
HELIX  309 BI3 THR C  246  ASN C  260  1                                  15    
HELIX  310 BI4 LYS C  269  ASP C  276  1                                   8    
HELIX  311 BI5 PRO C  280  THR C  299  1                                  20    
HELIX  312 BI6 THR C  323  TYR C  332  1                                  10    
HELIX  313 BI7 LYS C  340  TRP C  349  1                                  10    
HELIX  314 BI8 PRO C  371  ILE C  377  1                                   7    
HELIX  315 BI9 ILE C  377  MET C  391  1                                  15    
HELIX  316 BJ1 GLU C  392  ASN C  403  1                                  12    
HELIX  317 BJ2 GLU C  411  TYR C  415  5                                   5    
HELIX  318 BJ3 ASP C  416  PHE C  429  1                                  14    
HELIX  319 BJ4 GLN C  432  TYR C  443  1                                  12    
HELIX  320 BJ5 GLU C  447  ILE C  458  1                                  12    
HELIX  321 BJ6 SER C  507  ILE C  518  1                                  12    
HELIX  322 BJ7 SER C  582  LEU C  589  1                                   8    
HELIX  323 BJ8 LEU C  611  GLU C  614  5                                   4    
HELIX  324 BJ9 LEU C  615  TYR C  629  1                                  15    
HELIX  325 BK1 GLY C  648  SER C  662  1                                  15    
HELIX  326 BK2 ASP C  716  ARG C  725  1                                  10    
HELIX  327 BK3 ARG C  745  TRP C  757  1                                  13    
HELIX  328 BK4 SER C  759  TRP C  766  1                                   8    
HELIX  329 BK5 TYR C  791  ILE C  796  1                                   6    
HELIX  330 BK6 ILE C  796  GLU C  805  1                                  10    
HELIX  331 BK7 ASN C  830  ALA C  853  1                                  24    
HELIX  332 BK8 LEU C  872  ARG C  883  1                                  12    
HELIX  333 BK9 GLY C  913  THR C  922  1                                  10    
HELIX  334 BL1 PRO C  958  GLY C  975  1                                  18    
HELIX  335 BL2 LEU C  989  TYR C  998  1                                  10    
SHEET    1  AA 2 GLU A 188  VAL A 189  0                                        
SHEET    2  AA 2 ILE A 562  ASP A 563 -1                                        
SHEET    1  AB 3 THR A 200  VAL A 202  0                                        
SHEET    2  AB 3 VAL A 191  HIS A 194 -1                                        
SHEET    3  AB 3 TYR A 556  GLN A 558 -1                                        
SHEET    1  AC 2 LYS A 300  SER A 302  0                                        
SHEET    2  AC 2 LYS A 490  LYS A 492 -1                                        
SHEET    1  AD 2 ARG A 928  LEU A 929  0                                        
SHEET    2  AD 2 TYR J 203  LEU J 204 -1                                        
SHEET    1  AE 3 VAL A 967  ASP A 968  0                                        
SHEET    2  AE 3 VAL A1089  ASN A1091  1                                        
SHEET    3  AE 3 HIS A1097  VAL A1098 -1                                        
SHEET    1  AF 4 ILE A1013  LYS A1014  0                                        
SHEET    2  AF 4 ILE A1158  TYR A1164  1                                        
SHEET    3  AF 4 ARG A1167  PHE A1174 -1                                        
SHEET    4  AF 4 GLU A1051  THR A1052 -1                                        
SHEET    1  AG 5 ILE A1013  LYS A1014  0                                        
SHEET    2  AG 5 ILE A1158  TYR A1164  1                                        
SHEET    3  AG 5 ARG A1167  PHE A1174 -1                                        
SHEET    4  AG 5 SER A1046  VAL A1048 -1                                        
SHEET    5  AG 5 VAL A1250  TYR A1251 -1                                        
SHEET    1  AH 2 GLU A1051  THR A1052  0                                        
SHEET    2  AH 2 ARG A1167  PHE A1174 -1                                        
SHEET    1  AI 4 LEU A1258  PHE A1260  0                                        
SHEET    2  AI 4 PHE A1265  PRO A1271 -1                                        
SHEET    3  AI 4 ARG A1296  VAL A1304 -1                                        
SHEET    4  AI 4 VAL A1285  VAL A1289 -1                                        
SHEET    1  AJ 2 TRP A1414  GLN A1417  0                                        
SHEET    2  AJ 2 ILE A1422  PHE A1425 -1                                        
SHEET    1  AK 3 ILE A1825  GLN A1827  0                                        
SHEET    2  AK 3 LEU A1573  GLU A1576 -1                                        
SHEET    3  AK 3 ARG F 390  GLU F 392 -1                                        
SHEET    1  AL 2 GLN A1626  LEU A1627  0                                        
SHEET    2  AL 2 ILE A1632  PHE A1633 -1                                        
SHEET    1  AM 6 ILE A1678  LYS A1683  0                                        
SHEET    2  AM 6 ILE A1701  TRP A1709 -1                                        
SHEET    3  AM 6 THR A1729  ARG A1739 -1                                        
SHEET    4  AM 6 VAL A1773  ASP A1778  1                                        
SHEET    5  AM 6 MET A1783  GLY A1788 -1                                        
SHEET    6  AM 6 SER A1715  LEU A1716 -1                                        
SHEET    1  AN 6 ALA A1955  ARG A1957  0                                        
SHEET    2  AN 6 GLN A1932  VAL A1935  1                                        
SHEET    3  AN 6 LYS A1849  ASP A1853  1                                        
SHEET    4  AN 6 GLY A1877  ASN A1883 -1                                        
SHEET    5  AN 6 HIS A1888  ILE A1894 -1                                        
SHEET    6  AN 6 GLN A1985  VAL A1987 -1                                        
SHEET    1  AO 2 ARG A1859  THR A1861  0                                        
SHEET    2  AO 2 UNK x   2  UNK x   4 -1                                        
SHEET    1  AP 8 ASN A2168  ILE A2169  0                                        
SHEET    2  AP 8 SER A2299  TYR A2305  0                                        
SHEET    3  AP 8 ILE A2289  THR A2296 -1                                        
SHEET    4  AP 8 GLU A2254  GLN A2262  1                                        
SHEET    5  AP 8 ALA A2204  SER A2211 -1                                        
SHEET    6  AP 8 VAL A2218  VAL A2225 -1                                        
SHEET    7  AP 8 ASN A2348  PRO A2352 -1                                        
SHEET    8  AP 8 PHE A2374  TYR A2376  1                                        
SHEET    1  AQ 8 ASN A2168  ILE A2169  0                                        
SHEET    2  AQ 8 SER A2299  TYR A2305  0                                        
SHEET    3  AQ 8 ILE A2289  THR A2296 -1                                        
SHEET    4  AQ 8 GLU A2254  GLN A2262  1                                        
SHEET    5  AQ 8 ALA A2204  SER A2211 -1                                        
SHEET    6  AQ 8 VAL A2218  VAL A2225 -1                                        
SHEET    7  AQ 8 VAL A2182  PRO A2186  1                                        
SHEET    8  AQ 8 LEU A2339  SER A2342  1                                        
SHEET    1  AR 2 GLN A2229  HIS A2232  0                                        
SHEET    2  AR 2 SER A2235  ILE A2238 -1                                        
SHEET    1  HA 4 GLU H 166  LEU H 172  0                                        
SHEET    2  HA 4 SER H 460  ASN H 465 -1                                        
SHEET    3  HA 4 LEU H 452  GLY H 456 -1                                        
SHEET    4  HA 4 ILE H 440  ASP H 444 -1                                        
SHEET    1  HB 3 ALA H 180  LEU H 183  0                                        
SHEET    2  HB 3 VAL H 189  GLY H 193 -1                                        
SHEET    3  HB 3 LEU H 199  ASN H 203 -1                                        
SHEET    1  HC 4 ILE H 221  ASP H 225  0                                        
SHEET    2  HC 4 GLN H 233  ALA H 238 -1                                        
SHEET    3  HC 4 ILE H 243  TYR H 248 -1                                        
SHEET    4  HC 4 LEU H 255  LEU H 261 -1                                        
SHEET    1  HD 4 ILE H 268  HIS H 274  0                                        
SHEET    2  HD 4 PHE H 279  SER H 284 -1                                        
SHEET    3  HD 4 TRP H 289  ASP H 293 -1                                        
SHEET    4  HD 4 GLN H 298  GLU H 299 -1                                        
SHEET    1  HE 4 VAL H 310  SER H 312  0                                        
SHEET    2  HE 4 LEU H 321  GLY H 326 -1                                        
SHEET    3  HE 4 MET H 332  ASP H 335 -1                                        
SHEET    4  HE 4 SER H 340  LYS H 341 -1                                        
SHEET    1  HF 4 THR H 354  SER H 358  0                                        
SHEET    2  HF 4 GLN H 363  GLY H 367 -1                                        
SHEET    3  HF 4 ILE H 372  TRP H 376 -1                                        
SHEET    4  HF 4 ASN H 387  LEU H 390 -1                                        
SHEET    1  HG 4 VAL H 396  ARG H 400  0                                        
SHEET    2  HG 4 LYS H 409  GLY H 414 -1                                        
SHEET    3  HG 4 LEU H 418  SER H 423 -1                                        
SHEET    4  HG 4 LYS H 429  ALA H 434 -1                                        
SHEET    1  DA 6 GLN D   8  LEU D   9  0                                        
SHEET    2  DA 6 ALA D  57  ASP D  63  1                                        
SHEET    3  DA 6 LEU D  26  GLY D  32  1                                        
SHEET    4  DA 6 THR D  81  TYR D  86 -1                                        
SHEET    5  DA 6 LYS D  89  ASP D  94 -1                                        
SHEET    6  DA 6 LEU D 130  VAL D 132  1                                        
SHEET    1  GA 4 LYS G 366  ARG G 371  0                                        
SHEET    2  GA 4 GLY G 378  GLY G 384 -1                                        
SHEET    3  GA 4 TYR G 337  PHE G 344 -1                                        
SHEET    4  GA 4 ILE G 424  LYS G 426 -1                                        
SHEET    1  GB 4 LYS G 366  ARG G 371  0                                        
SHEET    2  GB 4 GLY G 378  GLY G 384 -1                                        
SHEET    3  GB 4 TYR G 337  PHE G 344 -1                                        
SHEET    4  GB 4 TYR G 431  LEU G 432 -1                                        
SHEET    1  GC 2 ILE G 424  LYS G 426  0                                        
SHEET    2  GC 2 TYR G 337  PHE G 344 -1                                        
SHEET    1  GD 2 PHE G 406  LEU G 408  0                                        
SHEET    2  GD 2 ILE G 415  MET G 417 -1                                        
SHEET    1  BA 7 ILE B 463  HIS B 464  0                                        
SHEET    2  BA 7 LEU B 703  PHE B 707 -1                                        
SHEET    3  BA 7 GLY B 884  ILE B 889  1                                        
SHEET    4  BA 7 THR B 844  LYS B 848  1                                        
SHEET    5  BA 7 ILE B 740  PHE B 743  1                                        
SHEET    6  BA 7 VAL B 827  CYS B 830  1                                        
SHEET    7  BA 7 THR B 803  HIS B 804  1                                        
SHEET    1  BB 7 VAL B 585  GLU B 587  0                                        
SHEET    2  BB 7 VAL B 604  SER B 607  1                                        
SHEET    3  BB 7 LYS B 556  ILE B 560  1                                        
SHEET    4  BB 7 VAL B 628  ILE B 633  1                                        
SHEET    5  BB 7 ARG B 666  SER B 671  1                                        
SHEET    6  BB 7 MET B 517  CYS B 520  1                                        
SHEET    7  BB 7 LEU B 691  TYR B 693  1                                        
SHEET    1  BC 2 VAL B 852  SER B 854  0                                        
SHEET    2  BC 2 SER B 859  GLU B 861 -1                                        
SHEET    1  BD 2 VAL B 987  LEU B 988  0                                        
SHEET    2  BD 2 GLU B 997  ALA B 998 -1                                        
SHEET    1  BE 3 THR B1205  PRO B1210  0                                        
SHEET    2  BE 3 VAL B1215  ILE B1222 -1                                        
SHEET    3  BE 3 PHE B1268  GLU B1275 -1                                        
SHEET    1  BF 4 ILE B1251  ILE B1259  0                                        
SHEET    2  BF 4 GLU B1237  GLU B1244 -1                                        
SHEET    3  BF 4 ASN B1287  SER B1294 -1                                        
SHEET    4  BF 4 PHE B1302  SER B1307 -1                                        
SHEET    1  BG 6 VAL B1366  PHE B1367  0                                        
SHEET    2  BG 6 ARG B1507  CYS B1510  1                                        
SHEET    3  BG 6 LEU B1470  TYR B1473  1                                        
SHEET    4  BG 6 ALA B1395  ILE B1398  1                                        
SHEET    5  BG 6 VAL B1444  ALA B1447  1                                        
SHEET    6  BG 6 ILE B1425  LYS B1427  1                                        
SHEET    1  BH 6 GLU B1545  PHE B1551  0                                        
SHEET    2  BH 6 LYS B1719  SER B1725  1                                        
SHEET    3  BH 6 GLU B1679  ILE B1682  1                                        
SHEET    4  BH 6 SER B1581  PHE B1584  1                                        
SHEET    5  BH 6 LEU B1664  ILE B1666  1                                        
SHEET    6  BH 6 GLY B1638  LEU B1640  1                                        
SHEET    1  BI 2 ASN B1686  ASP B1689  0                                        
SHEET    2  BI 2 LYS B1694  PRO B1697 -1                                        
SHEET    1  BJ 2 ILE B1820  ASP B1823  0                                        
SHEET    2  BJ 2 ILE B1843  THR B1846 -1                                        
SHEET    1  BK 3 TYR B2055  LEU B2057  0                                        
SHEET    2  BK 3 LYS B2068  ILE B2073 -1                                        
SHEET    3  BK 3 TYR B2126  ASP B2131 -1                                        
SHEET    1  BL 2 GLN B2085  VAL B2086  0                                        
SHEET    2  BL 2 LYS B2095  LEU B2096 -1                                        
SHEET    1  BM 4 GLU B2110  VAL B2117  0                                        
SHEET    2  BM 4 TRP B2099  GLU B2105 -1                                        
SHEET    3  BM 4 GLY B2136  CYS B2146 -1                                        
SHEET    4  BM 4 LYS B2154  VAL B2162 -1                                        
SHEET    1  KA 5 VAL k  29  GLN k  33  0                                        
SHEET    2  KA 5 LYS k  19  THR k  24 -1                                        
SHEET    3  KA 5 ILE k  92  ASP k  99 -1                                        
SHEET    4  KA 5 ILE l  85  ILE l  87 -1                                        
SHEET    5  KA 5 ILE l  39  LEU l  40 -1                                        
SHEET    1  KB12 THR k  85  LEU k  87  0                                        
SHEET    2  KB12 ILE n  69  VAL n  73 -1                                        
SHEET    3  KB12 ILE n  18  LEU n  23 -1                                        
SHEET    4  KB12 THR n  28  GLU n  35 -1                                        
SHEET    5  KB12 VAL n  42  THR n  50 -1                                        
SHEET    6  KB12 THR n  57  VAL n  64 -1                                        
SHEET    7  KB12 SER r  70  ALA r  73 -1                                        
SHEET    8  KB12 LYS r  14  ASN r  18 -1                                        
SHEET    9  KB12 ALA r  26  GLY r  31 -1                                        
SHEET   10  KB12 VAL r  39  LEU r  40 -1                                        
SHEET   11  KB12 THR r  61  ILE r  63 -1                                        
SHEET   12  KB12 LEU p  89  ILE p  90 -1                                        
SHEET    1  LA 2 GLN l  14  THR l  16  0                                        
SHEET    2  LA 2 TRP l  26  THR l  28 -1                                        
SHEET    1  LB 2 GLU l  18  LEU l  19  0                                        
SHEET    2  LB 2 ILE l  92  GLN l  94 -1                                        
SHEET    1  MA 4 PRO m  43  SER m  47  0                                        
SHEET    2  MA 4 LYS m  53  ALA m  60 -1                                        
SHEET    3  MA 4 VAL m  68  THR m  77 -1                                        
SHEET    4  MA 4 ASN m  86  ILE m  91 -1                                        
SHEET    1  MB10 VAL m 103  LEU m 105  0                                        
SHEET    2  MB10 VAL q  63  ILE q  73 -1                                        
SHEET    3  MB10 LEU q  51  VAL q  60 -1                                        
SHEET    4  MB10 GLU q  37  LEU q  42 -1                                        
SHEET    5  MB10 ARG q  26  LEU q  31 -1                                        
SHEET    6  MB10 VAL q  78  ARG q  82 -1                                        
SHEET    7  MB10 ILE p  80  LEU p  82 -1                                        
SHEET    8  MB10 VAL p  52  PRO p  61 -1                                        
SHEET    9  MB10 ILE p  37  ILE p  43 -1                                        
SHEET   10  MB10 PRO p  26  VAL p  27 -1                                        
SHEET    1  RA 2 MET r  44  GLU r  45  0                                        
SHEET    2  RA 2 HIS r  55  GLN r  56 -1                                        
SHEET    1  DA15 VAL d  56  PHE d  63  0                                        
SHEET    2  DA15 GLN d  43  THR d  50 -1                                        
SHEET    3  DA15 TYR d  29  GLU d  35 -1                                        
SHEET    4  DA15 ILE d  18  LEU d  23 -1                                        
SHEET    5  DA15 ILE d  69  VAL d  73 -1                                        
SHEET    6  DA15 GLU b  78  LEU b  87 -1                                        
SHEET    7  DA15 LEU b  43  ARG b  52 -1                                        
SHEET    8  DA15 VAL b  29  ALA b  36 -1                                        
SHEET    9  DA15 LYS b  19  THR b  24 -1                                        
SHEET   10  DA15 ILE b  92  ASP b  99 -1                                        
SHEET   11  DA15 ALA h  80  ILE h  87 -1                                        
SHEET   12  DA15 ALA h  38  THR h  46 -1                                        
SHEET   13  DA15 THR h  24  VAL h  32 -1                                        
SHEET   14  DA15 GLU h  13  LEU h  19 -1                                        
SHEET   15  DA15 ILE h  92  ILE h  96 -1                                        
SHEET    1  EA14 PRO e  26  TRP e  30  0                                        
SHEET    2  EA14 ILE e  37  ILE e  43 -1                                        
SHEET    3  EA14 VAL e  52  PRO e  61 -1                                        
SHEET    4  EA14 ILE e  80  LEU e  82 -1                                        
SHEET    5  EA14 VAL f  78  ARG f  82 -1                                        
SHEET    6  EA14 ARG f  26  LEU f  31 -1                                        
SHEET    7  EA14 GLU f  37  SER f  44 -1                                        
SHEET    8  EA14 LEU f  51  PHE f  59 -1                                        
SHEET    9  EA14 SER f  64  ILE f  73 -1                                        
SHEET   10  EA14 VAL j 101  LYS j 106 -1                                        
SHEET   11  EA14 PRO j  43  LEU j  48 -1                                        
SHEET   12  EA14 LYS j  53  VAL j  58 -1                                        
SHEET   13  EA14 MET j  67  TRP j  76 -1                                        
SHEET   14  EA14 ARG j  87  LEU j  96 -1                                        
SHEET    1  GA 2 HIS g  55  GLN g  56  0                                        
SHEET    2  GA 2 VAL g  38  GLU g  45  1                                        
SHEET    1  GB 2 GLN g  60  ILE g  63  0                                        
SHEET    2  GB 2 VAL g  38  GLU g  45 -1                                        
SHEET    1  GC 5 ILE g  68  ALA g  73  0                                        
SHEET    2  GC 5 ILE g  15  ILE g  19 -1                                        
SHEET    3  GC 5 ARG g  23  GLY g  31 -1                                        
SHEET    4  GC 5 VAL g  38  GLU g  45 -1                                        
SHEET    5  GC 5 HIS g  55  GLN g  56  1                                        
SHEET    1  GD 5 ILE g  68  ALA g  73  0                                        
SHEET    2  GD 5 ILE g  15  ILE g  19 -1                                        
SHEET    3  GD 5 ARG g  23  GLY g  31 -1                                        
SHEET    4  GD 5 VAL g  38  GLU g  45 -1                                        
SHEET    5  GD 5 GLN g  60  ILE g  63 -1                                        
SHEET    1  KA 4 LEU K  33  LYS K  35  0                                        
SHEET    2  KA 4 ALA K  99  THR K 103 -1                                        
SHEET    3  KA 4 SER K  49  ALA K  55 -1                                        
SHEET    4  KA 4 TYR K  78  VAL K  81  1                                        
SHEET    1  2A 3 GLU 2  14  LEU 2  19  0                                        
SHEET    2  2A 3 ILE 2  23  LEU 2  29 -1                                        
SHEET    3  2A 3 LEU 2  40  SER 2  44 -1                                        
SHEET    1  2B16 ASN 2  59  ILE 2  62  0                                        
SHEET    2  2B16 ILE 8  61  LEU 8  66 -1                                        
SHEET    3  2B16 LYS 8  11  LYS 8  17 -1                                        
SHEET    4  2B16 CYS 8  22  GLY 8  29 -1                                        
SHEET    5  2B16 LEU 8  36  ASN 8  43 -1                                        
SHEET    6  2B16 ALA 8  53  LEU 8  56 -1                                        
SHEET    7  2B16 ILE 4  76  LEU 4  81 -1                                        
SHEET    8  2B16 GLN 4  14  LEU 4  19 -1                                        
SHEET    9  2B16 ILE 4  24  ASN 4  31 -1                                        
SHEET   10  2B16 LEU 4  38  TYR 4  46 -1                                        
SHEET   11  2B16 LYS 4  65  ILE 4  71 -1                                        
SHEET   12  2B16 LEU 7  99  SER 7 104 -1                                        
SHEET   13  2B16 LYS 7  37  LEU 7  42 -1                                        
SHEET   14  2B16 LYS 7  46  GLY 7  54 -1                                        
SHEET   15  2B16 LEU 7  61  GLU 7  68 -1                                        
SHEET   16  2B16 ARG 7  87  LYS 7  88  1                                        
SHEET    1  2C21 ASN 2  59  ILE 2  62  0                                        
SHEET    2  2C21 ILE 8  61  LEU 8  66 -1                                        
SHEET    3  2C21 LYS 8  11  LYS 8  17 -1                                        
SHEET    4  2C21 CYS 8  22  GLY 8  29 -1                                        
SHEET    5  2C21 LEU 8  36  ASN 8  43 -1                                        
SHEET    6  2C21 ALA 8  53  LEU 8  56 -1                                        
SHEET    7  2C21 ILE 4  76  LEU 4  81 -1                                        
SHEET    8  2C21 GLN 4  14  LEU 4  19 -1                                        
SHEET    9  2C21 ILE 4  24  ASN 4  31 -1                                        
SHEET   10  2C21 LEU 4  38  TYR 4  46 -1                                        
SHEET   11  2C21 LYS 4  65  ILE 4  71 -1                                        
SHEET   12  2C21 LEU 7  99  SER 7 104 -1                                        
SHEET   13  2C21 LYS 7  37  LEU 7  42 -1                                        
SHEET   14  2C21 LYS 7  46  GLY 7  54 -1                                        
SHEET   15  2C21 LEU 7  61  GLU 7  68 -1                                        
SHEET   16  2C21 THR 7  92  ILE 7  94 -1                                        
SHEET   17  2C21 ILE 5  78  PRO 5  83 -1                                        
SHEET   18  2C21 LYS 5  19  LEU 5  24 -1                                        
SHEET   19  2C21 ARG 5  28  GLY 5  36 -1                                        
SHEET   20  2C21 VAL 5  43  LEU 5  52 -1                                        
SHEET   21  2C21 GLU 5  62  GLN 5  66 -1                                        
SHEET    1  2D26 ASN 2  59  ILE 2  62  0                                        
SHEET    2  2D26 ILE 8  61  LEU 8  66 -1                                        
SHEET    3  2D26 LYS 8  11  LYS 8  17 -1                                        
SHEET    4  2D26 CYS 8  22  GLY 8  29 -1                                        
SHEET    5  2D26 LEU 8  36  ASN 8  43 -1                                        
SHEET    6  2D26 ALA 8  53  LEU 8  56 -1                                        
SHEET    7  2D26 ILE 4  76  LEU 4  81 -1                                        
SHEET    8  2D26 GLN 4  14  LEU 4  19 -1                                        
SHEET    9  2D26 ILE 4  24  ASN 4  31 -1                                        
SHEET   10  2D26 LEU 4  38  TYR 4  46 -1                                        
SHEET   11  2D26 LYS 4  65  ILE 4  71 -1                                        
SHEET   12  2D26 LEU 7  99  SER 7 104 -1                                        
SHEET   13  2D26 LYS 7  37  LEU 7  42 -1                                        
SHEET   14  2D26 LYS 7  46  GLY 7  54 -1                                        
SHEET   15  2D26 LEU 7  61  GLU 7  68 -1                                        
SHEET   16  2D26 THR 7  92  ILE 7  94 -1                                        
SHEET   17  2D26 ILE 5  78  PRO 5  83 -1                                        
SHEET   18  2D26 LYS 5  19  LEU 5  24 -1                                        
SHEET   19  2D26 ARG 5  28  GLY 5  36 -1                                        
SHEET   20  2D26 VAL 5  43  LEU 5  52 -1                                        
SHEET   21  2D26 ARG 5  70  LEU 5  73  1                                        
SHEET   22  2D26 VAL 6  78  GLU 6  83 -1                                        
SHEET   23  2D26 THR 6  23  LEU 6  28 -1                                        
SHEET   24  2D26 LEU 6  32  ILE 6  41  1                                        
SHEET   25  2D26 VAL 6  47  TYR 6  56  1                                        
SHEET   26  2D26 LEU 6  63  PHE 6  67  1                                        
SHEET    1  2E31 ASN 2  59  ILE 2  62  0                                        
SHEET    2  2E31 ILE 8  61  LEU 8  66 -1                                        
SHEET    3  2E31 LYS 8  11  LYS 8  17 -1                                        
SHEET    4  2E31 CYS 8  22  GLY 8  29 -1                                        
SHEET    5  2E31 LEU 8  36  ASN 8  43 -1                                        
SHEET    6  2E31 ALA 8  53  LEU 8  56 -1                                        
SHEET    7  2E31 ILE 4  76  LEU 4  81 -1                                        
SHEET    8  2E31 GLN 4  14  LEU 4  19 -1                                        
SHEET    9  2E31 ILE 4  24  ASN 4  31 -1                                        
SHEET   10  2E31 LEU 4  38  TYR 4  46 -1                                        
SHEET   11  2E31 LYS 4  65  ILE 4  71 -1                                        
SHEET   12  2E31 LEU 7  99  SER 7 104 -1                                        
SHEET   13  2E31 LYS 7  37  LEU 7  42 -1                                        
SHEET   14  2E31 LYS 7  46  GLY 7  54 -1                                        
SHEET   15  2E31 LEU 7  61  GLU 7  68 -1                                        
SHEET   16  2E31 THR 7  92  ILE 7  94 -1                                        
SHEET   17  2E31 ILE 5  78  PRO 5  83 -1                                        
SHEET   18  2E31 LYS 5  19  LEU 5  24 -1                                        
SHEET   19  2E31 ARG 5  28  GLY 5  36 -1                                        
SHEET   20  2E31 VAL 5  43  LEU 5  52 -1                                        
SHEET   21  2E31 ARG 5  70  LEU 5  73  1                                        
SHEET   22  2E31 VAL 6  78  GLU 6  83 -1                                        
SHEET   23  2E31 THR 6  23  LEU 6  28 -1                                        
SHEET   24  2E31 LEU 6  32  ILE 6  41  1                                        
SHEET   25  2E31 VAL 6  47  TYR 6  56  1                                        
SHEET   26  2E31 VAL 6  71  LEU 6  73  1                                        
SHEET   27  2E31 VAL 3  73  SER 3  77 -1                                        
SHEET   28  2E31 ARG 3  15  LEU 3  20 -1                                        
SHEET   29  2E31 ARG 3  24  LEU 3  30 -1                                        
SHEET   30  2E31 ILE 3  39  TYR 3  49 -1                                        
SHEET   31  2E31 GLU 3  58  ARG 3  61 -1                                        
SHEET    1  2F32 ASN 2  59  ILE 2  62  0                                        
SHEET    2  2F32 ILE 8  61  LEU 8  66 -1                                        
SHEET    3  2F32 LYS 8  11  LYS 8  17 -1                                        
SHEET    4  2F32 CYS 8  22  GLY 8  29 -1                                        
SHEET    5  2F32 LEU 8  36  ASN 8  43 -1                                        
SHEET    6  2F32 ALA 8  53  LEU 8  56 -1                                        
SHEET    7  2F32 ILE 4  76  LEU 4  81 -1                                        
SHEET    8  2F32 GLN 4  14  LEU 4  19 -1                                        
SHEET    9  2F32 ILE 4  24  ASN 4  31 -1                                        
SHEET   10  2F32 LEU 4  38  TYR 4  46 -1                                        
SHEET   11  2F32 LYS 4  65  ILE 4  71 -1                                        
SHEET   12  2F32 LEU 7  99  SER 7 104 -1                                        
SHEET   13  2F32 LYS 7  37  LEU 7  42 -1                                        
SHEET   14  2F32 LYS 7  46  GLY 7  54 -1                                        
SHEET   15  2F32 LEU 7  61  GLU 7  68 -1                                        
SHEET   16  2F32 THR 7  92  ILE 7  94 -1                                        
SHEET   17  2F32 ILE 5  78  PRO 5  83 -1                                        
SHEET   18  2F32 LYS 5  19  LEU 5  24 -1                                        
SHEET   19  2F32 ARG 5  28  GLY 5  36 -1                                        
SHEET   20  2F32 VAL 5  43  LEU 5  52 -1                                        
SHEET   21  2F32 ARG 5  70  LEU 5  73  1                                        
SHEET   22  2F32 VAL 6  78  GLU 6  83 -1                                        
SHEET   23  2F32 THR 6  23  LEU 6  28 -1                                        
SHEET   24  2F32 LEU 6  32  ILE 6  41  1                                        
SHEET   25  2F32 VAL 6  47  TYR 6  56  1                                        
SHEET   26  2F32 VAL 6  71  LEU 6  73  1                                        
SHEET   27  2F32 VAL 3  73  SER 3  77 -1                                        
SHEET   28  2F32 ARG 3  15  LEU 3  20 -1                                        
SHEET   29  2F32 ARG 3  24  LEU 3  30 -1                                        
SHEET   30  2F32 ILE 3  39  TYR 3  49 -1                                        
SHEET   31  2F32 MET 3  65  ILE 3  68 -1                                        
SHEET   32  2F32 TYR 2  69  VAL 2  70 -1                                        
SHEET    1  3A 2 GLU 3  58  ARG 3  61  0                                        
SHEET    2  3A 2 ILE 3  39  TYR 3  49 -1                                        
SHEET    1  5A 2 GLU 5  62  GLN 5  66  0                                        
SHEET    2  5A 2 VAL 5  43  LEU 5  52 -1                                        
SHEET    1  6A 2 LEU 6  63  PHE 6  67  0                                        
SHEET    2  6A 2 VAL 6  47  TYR 6  56  1                                        
SHEET    1  7A 2 ARG 7  87  LYS 7  88  0                                        
SHEET    2  7A 2 LEU 7  61  GLU 7  68  1                                        
SHEET    1  CA 7 SER C 196  CYS C 200  0                                        
SHEET    2  CA 7 ARG C 208  ASP C 214 -1                                        
SHEET    3  CA 7 ILE C 133  ILE C 139  1                                        
SHEET    4  CA 7 LEU C 234  ASP C 240  1                                        
SHEET    5  CA 7 ALA C 262  ASN C 268  1                                        
SHEET    6  CA 7 PHE C 313  SER C 315  1                                        
SHEET    7  CA 7 PHE C 320  PHE C 322 -1                                        
SHEET    1  CB 8 SER C 536  GLU C 538  0                                        
SHEET    2  CB 8 THR C 498  ASP C 503 -1                                        
SHEET    3  CB 8 ALA C 575  SER C 579 -1                                        
SHEET    4  CB 8 LEU C 468  VAL C 476 -1                                        
SHEET    5  CB 8 TRP C 483  SER C 490 -1                                        
SHEET    6  CB 8 ILE C 561  ILE C 564 -1                                        
SHEET    7  CB 8 ILE C 542  GLY C 546 -1                                        
SHEET    8  CB 8 TYR C 549  PRO C 552 -1                                        
SHEET    1  CC 2 LEU C 492  LYS C 494  0                                        
SHEET    2  CC 2 GLU C 555  HIS C 557 -1                                        
SHEET    1  CD 3 HIS C 642  GLY C 646  0                                        
SHEET    2  CD 3 PHE C 603  LEU C 607 -1                                        
SHEET    3  CD 3 LEU C 674  THR C 675 -1                                        
SHEET    1  CE 2 SER C 678  CYS C 681  0                                        
SHEET    2  CE 2 PRO C 855  ASP C 865 -1                                        
SHEET    1  CF 2 THR C 867  HIS C 869  0                                        
SHEET    2  CF 2 LEU C 899  PRO C 907 -1                                        
SHEET    1  CG 2 ARG C 887  LYS C 893  0                                        
SHEET    2  CG 2 LEU C 899  PRO C 907 -1                                        
SHEET    1  CH 2 GLN C 929  TYR C 931  0                                        
SHEET    2  CH 2 PRO C 855  ASP C 865  1                                        
SHEET    1  CI 2 TRP C 937  LYS C 939  0                                        
SHEET    2  CI 2 PRO C 855  ASP C 865  1                                        
SHEET    1  CJ 3 ILE C 708  PRO C 714  0                                        
SHEET    2  CJ 3 VAL C 816  ILE C 823 -1                                        
SHEET    3  CJ 3 LEU C 774  ASP C 777  1                                        
CISPEP   1 PHE A  239    PRO A  240          0         1.26                     
CISPEP   2 ARG A  284    PRO A  285          0         0.62                     
CISPEP   3 THR A  554    LYS A  555          0        19.40                     
CISPEP   4 LYS A 1014    PRO A 1015          0         0.66                     
CISPEP   5 ILE A 1488    PRO A 1489          0        -6.15                     
CISPEP   6 THR A 2332    PHE A 2333          0        -0.84                     
CISPEP   7 GLU H  404    ASP H  405          0         5.80                     
CISPEP   8 THR J  239    ASN J  240          0        11.06                     
CISPEP   9 ALA J  254    ARG J  255          0        11.60                     
CISPEP  10 SER F   61    PRO F   62          0         9.63                     
CISPEP  11 LEU F   95    PRO F   96          0        17.98                     
CISPEP  12 LEU B  448    PRO B  449          0         1.30                     
CISPEP  13 SER B 1370    GLY B 1371          0         3.66                     
CISPEP  14 THR B 1625    ASP B 1626          0         3.49                     
CISPEP  15 VAL B 1707    GLY B 1708          0        -3.64                     
CISPEP  16 ILE l   96    LEU l   97          0        -7.97                     
CISPEP  17 GLY m   81    LYS m   82          0         1.60                     
CISPEP  18 ALA n   81    PRO n   82          0        -2.97                     
CISPEP  19 ALA d   81    PRO d   82          0        -9.80                     
CISPEP  20 GLY j   81    LYS j   82          0        -1.67                     
CISPEP  21 PHE K    9    PRO K   10          0         8.18                     
CISPEP  22 GLU K   59    PRO K   60          0         2.54                     
CISPEP  23 ASN C  259    ASN C  260          0         3.20                     
CISPEP  24 ASN C  358    PHE C  359          0         8.39                     
CISPEP  25 ARG C  360    THR C  361          0        11.96                     
CISPEP  26 PHE C  364    GLU C  365          0        -5.85                     
CISPEP  27 GLN C  444    PRO C  445          0       -10.95                     
CISPEP  28 LEU C  545    GLY C  546          0         0.90                     
CISPEP  29 ASN C  772    VAL C  773          0        24.23                     
CISPEP  30 PRO C  987    THR C  988          0        12.48                     
CISPEP  31 THR C  988    LEU C  989          0        -0.05                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.001840  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.001840  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.001840        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system