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Database: PDB
Entry: 5GAO
LinkDB: 5GAO
Original site: 5GAO 
HEADER    TRANSCRIPTION                           15-DEC-15   5GAO              
TITLE     HEAD REGION OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B;      
COMPND   3 CHAIN: k;                                                            
COMPND   4 SYNONYM: SNRNP-B,SM PROTEIN B,SMB;                                   
COMPND   5 OTHER_DETAILS: THE SMB PROTEIN FROM THE U4 SNRNP SM PROTEIN RING. THE
COMPND   6 C-TERMINUS IS DISORDERED IN THIS AND OTHER PREVIOUSLY REPORTED       
COMPND   7 STRUCTURES.;                                                         
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN SM D1;                     
COMPND  10 CHAIN: l;                                                            
COMPND  11 SYNONYM: SM-D1,SNRNP CORE PROTEIN D1;                                
COMPND  12 OTHER_DETAILS: THE SMD1 PROTEIN FROM THE U4 SNRNP SM PROTEIN RING.;  
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2;                     
COMPND  15 CHAIN: m;                                                            
COMPND  16 SYNONYM: SM-D2,SNRNP CORE PROTEIN D2;                                
COMPND  17 OTHER_DETAILS: THE SMD2 PROTEIN FROM THE U4 SNRNP SM PROTEIN RING.;  
COMPND  18 MOL_ID: 4;                                                           
COMPND  19 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN SM D3;                     
COMPND  20 CHAIN: n;                                                            
COMPND  21 SYNONYM: SM-D3,SNRNP CORE PROTEIN D3, U4 SMD3;                       
COMPND  22 OTHER_DETAILS: THE SMD3 PROTEIN FROM THE U4 SNRNP SM PROTEIN RING.;  
COMPND  23 MOL_ID: 5;                                                           
COMPND  24 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN E;                         
COMPND  25 CHAIN: p;                                                            
COMPND  26 SYNONYM: SNRNP-E,SM PROTEIN E,SME;                                   
COMPND  27 OTHER_DETAILS: THE SME PROTEIN FROM THE U4 SNRNP SM PROTEIN RING.;   
COMPND  28 MOL_ID: 6;                                                           
COMPND  29 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN F;                         
COMPND  30 CHAIN: q;                                                            
COMPND  31 SYNONYM: SNRNP-F,SM PROTEIN F, U4 SMF;                               
COMPND  32 OTHER_DETAILS: THE SMF PROTEIN FROM THE U4 SNRNP SM PROTEIN RING.;   
COMPND  33 MOL_ID: 7;                                                           
COMPND  34 MOLECULE: SMALL NUCLEAR RIBONUCLEOPROTEIN G;                         
COMPND  35 CHAIN: r;                                                            
COMPND  36 SYNONYM: SNRNP-G,SM PROTEIN G, U4 SMG;                               
COMPND  37 OTHER_DETAILS: THE SMG PROTEIN FROM THE U4 SNRNP SM PROTEIN RING.;   
COMPND  38 MOL_ID: 8;                                                           
COMPND  39 MOLECULE: SNU66;                                                     
COMPND  40 CHAIN: E;                                                            
COMPND  41 OTHER_DETAILS: NB: SNU66 PROTEIN HAS BEEN MOSTLY FITTED AS POLY(ALA) 
COMPND  42 INTO HELICES AND EXTENDED POLYPEPTIDE WITHIN THE EM MAP. THE AUTHORS 
COMPND  43 DO NOT BELIEVE THE NUMBERING TO BE ACCURATE AND IT IS LIKELY         
COMPND  44 INCORRECT.;                                                          
COMPND  45 MOL_ID: 9;                                                           
COMPND  46 MOLECULE: PRE-MRNA-SPLICING HELICASE BRR2;                           
COMPND  47 CHAIN: B;                                                            
COMPND  48 SYNONYM: PROTEIN SNU246, BRR2 RNA HELICASE;                          
COMPND  49 EC: 3.6.4.13;                                                        
COMPND  50 OTHER_DETAILS: BRR2 RNA HELICASE LOADED ONTO U4 SNRNA STRAND OF THE  
COMPND  51 U4/U6 DUPLEX BETWEEN STEM 1 DUPLEX AND THE 3' STEM LOOP.;            
COMPND  52 MOL_ID: 10;                                                          
COMPND  53 MOLECULE: SACCHAROMYCES CEREVISIAE STRAIN UOA_M2 CHROMOSOME 5        
COMPND  54 SEQUENCE;                                                            
COMPND  55 CHAIN: V;                                                            
COMPND  56 OTHER_DETAILS: THIS U4 SNRNA REGION HAS A DISORDERED REGION BETWEEN  
COMPND  57 STEM 1 OF THE U4/U6 SNRNA DUPLEX AND WHERE THE RNA IS LOADED INTO    
COMPND  58 BRR2 PROTEIN. THE APICAL PART OF THE 3' STEM LOOP AND THE REGION     
COMPND  59 FOLLOWING THE SM SITE ARE ALSO DISORDERED.;                          
COMPND  60 MOL_ID: 11;                                                          
COMPND  61 MOLECULE: PRE-MRNA-SPLICING FACTOR 8;                                
COMPND  62 CHAIN: A;                                                            
COMPND  63 SYNONYM: PRP8 JAB1/MPN DOMAIN;                                       
COMPND  64 OTHER_DETAILS: PRP8 JAB1/MPN DOMAIN IS CONNECTED TO THE REST OF THE  
COMPND  65 PRP8 PROTEIN BY A FLEXIBLE LINKER PEPTIDE.                           
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   3 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   4 ORGANISM_TAXID: 4932;                                                
SOURCE   5 STRAIN: BCY123;                                                      
SOURCE   6 MOL_ID: 2;                                                           
SOURCE   7 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   8 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   9 ORGANISM_TAXID: 4932;                                                
SOURCE  10 STRAIN: BCY123;                                                      
SOURCE  11 MOL_ID: 3;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  13 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  14 ORGANISM_TAXID: 4932;                                                
SOURCE  15 STRAIN: BCY123;                                                      
SOURCE  16 MOL_ID: 4;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  18 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  19 ORGANISM_TAXID: 4932;                                                
SOURCE  20 STRAIN: BCY123;                                                      
SOURCE  21 MOL_ID: 5;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  23 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  24 ORGANISM_TAXID: 4932;                                                
SOURCE  25 STRAIN: BCY123;                                                      
SOURCE  26 MOL_ID: 6;                                                           
SOURCE  27 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  28 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  29 ORGANISM_TAXID: 4932;                                                
SOURCE  30 STRAIN: BCY123;                                                      
SOURCE  31 MOL_ID: 7;                                                           
SOURCE  32 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  33 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  34 ORGANISM_TAXID: 4932;                                                
SOURCE  35 STRAIN: BCY123;                                                      
SOURCE  36 MOL_ID: 8;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  38 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  39 ORGANISM_TAXID: 4932;                                                
SOURCE  40 STRAIN: BCY123;                                                      
SOURCE  41 MOL_ID: 9;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  43 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  44 ORGANISM_TAXID: 4932;                                                
SOURCE  45 STRAIN: BCY123;                                                      
SOURCE  46 MOL_ID: 10;                                                          
SOURCE  47 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  48 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  49 ORGANISM_TAXID: 4932;                                                
SOURCE  50 STRAIN: BCY123;                                                      
SOURCE  51 MOL_ID: 11;                                                          
SOURCE  52 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  53 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  54 ORGANISM_TAXID: 4932;                                                
SOURCE  55 STRAIN: BCY123                                                       
KEYWDS    TRANSCRIPTION, PRE-MRNA SPLICING, SNRNP, GTPASE, SPLICEOSOME          
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    T.H.D.NGUYEN,W.P.GALEJ,X.C.BAI,C.OUBRIDGE,S.H.W.SCHERES,A.J.NEWMAN,   
AUTHOR   2 K.NAGAI                                                              
REVDAT   4   03-OCT-18 5GAO    1       REMARK                                   
REVDAT   3   30-AUG-17 5GAO    1       REMARK                                   
REVDAT   2   02-MAR-16 5GAO    1       JRNL                                     
REVDAT   1   27-JAN-16 5GAO    0                                                
JRNL        AUTH   T.H.NGUYEN,W.P.GALEJ,X.C.BAI,C.OUBRIDGE,A.J.NEWMAN,          
JRNL        AUTH 2 S.H.SCHERES,K.NAGAI                                          
JRNL        TITL   CRYO-EM STRUCTURE OF THE YEAST U4/U6.U5 TRI-SNRNP AT 3.7     
JRNL        TITL 2 ANGSTROM RESOLUTION.                                         
JRNL        REF    NATURE                        V. 530   298 2016              
JRNL        REFN                   ESSN 1476-4687                               
JRNL        PMID   26829225                                                     
JRNL        DOI    10.1038/NATURE16940                                          
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   T.H.D.NGUYEN,W.GALEJ,X.C.BAI,C.G.SAVVA,A.J.NEWMAN,           
REMARK   1  AUTH 2 S.H.W.SCHERES,K.NAGAI                                        
REMARK   1  TITL   THE ARCHITECTURE OF THE SPLICEOSOMAL U4/U6.U5 TRI-SNRNP.     
REMARK   1  REF    NATURE                        V. 523    47 2015              
REMARK   1  REFN                   ESSN 1476-4687                               
REMARK   1  PMID   26106855                                                     
REMARK   1  DOI    10.1038/NATURE14548                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION, DIGITALMICROGRAPH, CTFFIND,       
REMARK   3                            COOT, REFMAC, RELION, RELION, RELION,     
REMARK   3                            RELION                                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : 4BGD                                
REMARK   3   REFINEMENT SPACE             : RECIPROCAL                          
REMARK   3   REFINEMENT PROTOCOL          : OTHER                               
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.200                          
REMARK   3   NUMBER OF PARTICLES               : 140155                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING ONLY            
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5GAO COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 08-JAN-16.                  
REMARK 100 THE DEPOSITION ID IS D_1001300040.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : HEAD REGION OF THE YEAST          
REMARK 245                                    SPLICEOSOMAL U4/U6.U5 TRI-SNRNP   
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.20                              
REMARK 245   SAMPLE SUPPORT DETAILS         : GRIDS ARE MADE OF HOLEY CARBON,   
REMARK 245                                    CARBON-COATED AND GLOW            
REMARK 245                                    DISCHARGED IN N-AMYLAMINE.        
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.90                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 2477                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : 500.00                         
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3500.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.00                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 38.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 81000                          
REMARK 245   CALIBRATED MAGNIFICATION          : 35714                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 11-MERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 11-MERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 35630 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 132600 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -169.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: k, l, m, n, p, q, r, E, B, V,         
REMARK 350                    AND CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET k     1                                                      
REMARK 465     SER k     2                                                      
REMARK 465     LYS k     3                                                      
REMARK 465     THR k    56                                                      
REMARK 465     GLN k    57                                                      
REMARK 465     LEU k    58                                                      
REMARK 465     ASP k    59                                                      
REMARK 465     LYS k    60                                                      
REMARK 465     LEU k    61                                                      
REMARK 465     ARG k    62                                                      
REMARK 465     PRO k    63                                                      
REMARK 465     ARG k    64                                                      
REMARK 465     LYS k    65                                                      
REMARK 465     ASP k    66                                                      
REMARK 465     SER k    67                                                      
REMARK 465     LYS k    68                                                      
REMARK 465     ASP k    69                                                      
REMARK 465     GLY k    70                                                      
REMARK 465     THR k    71                                                      
REMARK 465     THR k    72                                                      
REMARK 465     LEU k    73                                                      
REMARK 465     ASN k    74                                                      
REMARK 465     LEU k   103                                                      
REMARK 465     SER k   104                                                      
REMARK 465     LYS k   105                                                      
REMARK 465     LYS k   106                                                      
REMARK 465     GLU k   107                                                      
REMARK 465     ARG k   108                                                      
REMARK 465     LEU k   109                                                      
REMARK 465     VAL k   110                                                      
REMARK 465     ARG k   111                                                      
REMARK 465     ASP k   112                                                      
REMARK 465     LYS k   113                                                      
REMARK 465     LYS k   114                                                      
REMARK 465     GLU k   115                                                      
REMARK 465     LYS k   116                                                      
REMARK 465     LYS k   117                                                      
REMARK 465     GLN k   118                                                      
REMARK 465     ALA k   119                                                      
REMARK 465     GLN k   120                                                      
REMARK 465     LYS k   121                                                      
REMARK 465     GLN k   122                                                      
REMARK 465     THR k   123                                                      
REMARK 465     LYS k   124                                                      
REMARK 465     LEU k   125                                                      
REMARK 465     ARG k   126                                                      
REMARK 465     LYS k   127                                                      
REMARK 465     GLU k   128                                                      
REMARK 465     LYS k   129                                                      
REMARK 465     GLU k   130                                                      
REMARK 465     LYS k   131                                                      
REMARK 465     LYS k   132                                                      
REMARK 465     PRO k   133                                                      
REMARK 465     GLY k   134                                                      
REMARK 465     LYS k   135                                                      
REMARK 465     ILE k   136                                                      
REMARK 465     ALA k   137                                                      
REMARK 465     LYS k   138                                                      
REMARK 465     PRO k   139                                                      
REMARK 465     ASN k   140                                                      
REMARK 465     THR k   141                                                      
REMARK 465     ALA k   142                                                      
REMARK 465     ASN k   143                                                      
REMARK 465     ALA k   144                                                      
REMARK 465     LYS k   145                                                      
REMARK 465     HIS k   146                                                      
REMARK 465     THR k   147                                                      
REMARK 465     SER k   148                                                      
REMARK 465     SER k   149                                                      
REMARK 465     ASN k   150                                                      
REMARK 465     SER k   151                                                      
REMARK 465     ARG k   152                                                      
REMARK 465     GLU k   153                                                      
REMARK 465     ILE k   154                                                      
REMARK 465     ALA k   155                                                      
REMARK 465     GLN k   156                                                      
REMARK 465     PRO k   157                                                      
REMARK 465     SER k   158                                                      
REMARK 465     SER k   159                                                      
REMARK 465     SER k   160                                                      
REMARK 465     ARG k   161                                                      
REMARK 465     TYR k   162                                                      
REMARK 465     ASN k   163                                                      
REMARK 465     GLY k   164                                                      
REMARK 465     GLY k   165                                                      
REMARK 465     ASN k   166                                                      
REMARK 465     ASP k   167                                                      
REMARK 465     ASN k   168                                                      
REMARK 465     ILE k   169                                                      
REMARK 465     GLY k   170                                                      
REMARK 465     ALA k   171                                                      
REMARK 465     ASN k   172                                                      
REMARK 465     ARG k   173                                                      
REMARK 465     SER k   174                                                      
REMARK 465     ARG k   175                                                      
REMARK 465     PHE k   176                                                      
REMARK 465     ASN k   177                                                      
REMARK 465     ASN k   178                                                      
REMARK 465     GLU k   179                                                      
REMARK 465     ALA k   180                                                      
REMARK 465     PRO k   181                                                      
REMARK 465     PRO k   182                                                      
REMARK 465     GLN k   183                                                      
REMARK 465     THR k   184                                                      
REMARK 465     ARG k   185                                                      
REMARK 465     LYS k   186                                                      
REMARK 465     PHE k   187                                                      
REMARK 465     GLN k   188                                                      
REMARK 465     PRO k   189                                                      
REMARK 465     PRO k   190                                                      
REMARK 465     PRO k   191                                                      
REMARK 465     GLY k   192                                                      
REMARK 465     PHE k   193                                                      
REMARK 465     LYS k   194                                                      
REMARK 465     ARG k   195                                                      
REMARK 465     LYS k   196                                                      
REMARK 465     GLN l    49                                                      
REMARK 465     PRO l    50                                                      
REMARK 465     ARG l    51                                                      
REMARK 465     LEU l    52                                                      
REMARK 465     ASN l    53                                                      
REMARK 465     LYS l    54                                                      
REMARK 465     LEU l    55                                                      
REMARK 465     ASN l    56                                                      
REMARK 465     SER l    57                                                      
REMARK 465     ASN l    58                                                      
REMARK 465     GLY l    59                                                      
REMARK 465     ILE l    60                                                      
REMARK 465     ALA l    61                                                      
REMARK 465     MET l    62                                                      
REMARK 465     ALA l    63                                                      
REMARK 465     SER l    64                                                      
REMARK 465     LEU l    65                                                      
REMARK 465     TYR l    66                                                      
REMARK 465     LEU l    67                                                      
REMARK 465     THR l    68                                                      
REMARK 465     GLY l    69                                                      
REMARK 465     GLY l    70                                                      
REMARK 465     GLN l    71                                                      
REMARK 465     GLN l    72                                                      
REMARK 465     PRO l    73                                                      
REMARK 465     THR l    74                                                      
REMARK 465     ALA l    75                                                      
REMARK 465     SER l   119                                                      
REMARK 465     GLY l   120                                                      
REMARK 465     GLN l   121                                                      
REMARK 465     ILE l   122                                                      
REMARK 465     ALA l   123                                                      
REMARK 465     ASN l   124                                                      
REMARK 465     ASP l   125                                                      
REMARK 465     PRO l   126                                                      
REMARK 465     SER l   127                                                      
REMARK 465     LYS l   128                                                      
REMARK 465     LYS l   129                                                      
REMARK 465     ARG l   130                                                      
REMARK 465     ARG l   131                                                      
REMARK 465     ARG l   132                                                      
REMARK 465     ASP l   133                                                      
REMARK 465     PHE l   134                                                      
REMARK 465     GLY l   135                                                      
REMARK 465     ALA l   136                                                      
REMARK 465     PRO l   137                                                      
REMARK 465     ALA l   138                                                      
REMARK 465     ASN l   139                                                      
REMARK 465     LYS l   140                                                      
REMARK 465     ARG l   141                                                      
REMARK 465     PRO l   142                                                      
REMARK 465     ARG l   143                                                      
REMARK 465     ARG l   144                                                      
REMARK 465     GLY l   145                                                      
REMARK 465     LEU l   146                                                      
REMARK 465     MET m     1                                                      
REMARK 465     SER m     2                                                      
REMARK 465     SER m     3                                                      
REMARK 465     GLN m     4                                                      
REMARK 465     ILE m     5                                                      
REMARK 465     ILE m     6                                                      
REMARK 465     ASP m     7                                                      
REMARK 465     ARG m     8                                                      
REMARK 465     PRO m     9                                                      
REMARK 465     LYS m    10                                                      
REMARK 465     HIS m    11                                                      
REMARK 465     GLU m    12                                                      
REMARK 465     LEU m    13                                                      
REMARK 465     SER m    14                                                      
REMARK 465     VAL m   109                                                      
REMARK 465     GLU m   110                                                      
REMARK 465     MET n     1                                                      
REMARK 465     THR n     2                                                      
REMARK 465     MET n     3                                                      
REMARK 465     LYS n    86                                                      
REMARK 465     ASN n    87                                                      
REMARK 465     SER n    88                                                      
REMARK 465     SER n    89                                                      
REMARK 465     ARG n    90                                                      
REMARK 465     PRO n    91                                                      
REMARK 465     MET n    92                                                      
REMARK 465     PRO n    93                                                      
REMARK 465     PRO n    94                                                      
REMARK 465     ILE n    95                                                      
REMARK 465     ARG n    96                                                      
REMARK 465     GLY n    97                                                      
REMARK 465     PRO n    98                                                      
REMARK 465     LYS n    99                                                      
REMARK 465     ARG n   100                                                      
REMARK 465     ARG n   101                                                      
REMARK 465     MET p     1                                                      
REMARK 465     SER p     2                                                      
REMARK 465     ASN p     3                                                      
REMARK 465     LYS p     4                                                      
REMARK 465     VAL p     5                                                      
REMARK 465     LYS p     6                                                      
REMARK 465     THR p     7                                                      
REMARK 465     LYS p     8                                                      
REMARK 465     ALA p     9                                                      
REMARK 465     ASP p    66                                                      
REMARK 465     GLY p    67                                                      
REMARK 465     LYS p    68                                                      
REMARK 465     GLU p    69                                                      
REMARK 465     ASP p    70                                                      
REMARK 465     VAL p    71                                                      
REMARK 465     GLU p    72                                                      
REMARK 465     ALA p    93                                                      
REMARK 465     ASP p    94                                                      
REMARK 465     MET q     1                                                      
REMARK 465     SER q     2                                                      
REMARK 465     GLU q     3                                                      
REMARK 465     SER q     4                                                      
REMARK 465     SER q     5                                                      
REMARK 465     ASP q     6                                                      
REMARK 465     ILE q     7                                                      
REMARK 465     SER q     8                                                      
REMARK 465     ALA q     9                                                      
REMARK 465     MET q    10                                                      
REMARK 465     GLN q    11                                                      
REMARK 465     LEU q    84                                                      
REMARK 465     PRO q    85                                                      
REMARK 465     ASN q    86                                                      
REMARK 465     MET r     1                                                      
REMARK 465     ASN r    47                                                      
REMARK 465     GLY r    48                                                      
REMARK 465     GLU r    49                                                      
REMARK 465     ASP r    50                                                      
REMARK 465     PRO r    51                                                      
REMARK 465     ALA r    52                                                      
REMARK 465     ILE r    77                                                      
REMARK 465     MET B     1                                                      
REMARK 465     THR B     2                                                      
REMARK 465     GLU B     3                                                      
REMARK 465     HIS B     4                                                      
REMARK 465     GLU B     5                                                      
REMARK 465     THR B     6                                                      
REMARK 465     LYS B     7                                                      
REMARK 465     ASP B     8                                                      
REMARK 465     LYS B     9                                                      
REMARK 465     ALA B    10                                                      
REMARK 465     LYS B    11                                                      
REMARK 465     LYS B    12                                                      
REMARK 465     ILE B    13                                                      
REMARK 465     ARG B    14                                                      
REMARK 465     GLU B    15                                                      
REMARK 465     ILE B    16                                                      
REMARK 465     TYR B    17                                                      
REMARK 465     ARG B    18                                                      
REMARK 465     TYR B    19                                                      
REMARK 465     ASP B    20                                                      
REMARK 465     GLU B    21                                                      
REMARK 465     MET B    22                                                      
REMARK 465     SER B    23                                                      
REMARK 465     ASN B    24                                                      
REMARK 465     LYS B    25                                                      
REMARK 465     VAL B    26                                                      
REMARK 465     LEU B    27                                                      
REMARK 465     LYS B    28                                                      
REMARK 465     VAL B    29                                                      
REMARK 465     ASP B    30                                                      
REMARK 465     LYS B    31                                                      
REMARK 465     ARG B    32                                                      
REMARK 465     PHE B    33                                                      
REMARK 465     MET B    34                                                      
REMARK 465     ASN B    35                                                      
REMARK 465     THR B    36                                                      
REMARK 465     SER B    37                                                      
REMARK 465     GLN B    38                                                      
REMARK 465     ASN B    39                                                      
REMARK 465     PRO B    40                                                      
REMARK 465     GLN B    41                                                      
REMARK 465     ARG B    42                                                      
REMARK 465     ASP B    43                                                      
REMARK 465     ALA B    44                                                      
REMARK 465     GLU B    45                                                      
REMARK 465     ILE B    46                                                      
REMARK 465     SER B    47                                                      
REMARK 465     GLN B    48                                                      
REMARK 465     PRO B    49                                                      
REMARK 465     LYS B    50                                                      
REMARK 465     SER B    51                                                      
REMARK 465     MET B    52                                                      
REMARK 465     SER B    53                                                      
REMARK 465     GLY B    54                                                      
REMARK 465     ARG B    55                                                      
REMARK 465     ILE B    56                                                      
REMARK 465     SER B    57                                                      
REMARK 465     ALA B    58                                                      
REMARK 465     LYS B    59                                                      
REMARK 465     ASP B    60                                                      
REMARK 465     MET B    61                                                      
REMARK 465     GLY B    62                                                      
REMARK 465     GLN B    63                                                      
REMARK 465     GLY B    64                                                      
REMARK 465     LEU B    65                                                      
REMARK 465     CYS B    66                                                      
REMARK 465     ASN B    67                                                      
REMARK 465     ASN B    68                                                      
REMARK 465     ILE B    69                                                      
REMARK 465     ASN B    70                                                      
REMARK 465     LYS B    71                                                      
REMARK 465     GLY B    72                                                      
REMARK 465     LEU B    73                                                      
REMARK 465     LYS B    74                                                      
REMARK 465     GLU B    75                                                      
REMARK 465     ASN B    76                                                      
REMARK 465     ASP B    77                                                      
REMARK 465     VAL B    78                                                      
REMARK 465     ALA B    79                                                      
REMARK 465     VAL B    80                                                      
REMARK 465     GLU B    81                                                      
REMARK 465     LYS B    82                                                      
REMARK 465     THR B    83                                                      
REMARK 465     GLY B    84                                                      
REMARK 465     LYS B    85                                                      
REMARK 465     SER B    86                                                      
REMARK 465     ALA B    87                                                      
REMARK 465     SER B    88                                                      
REMARK 465     LEU B    89                                                      
REMARK 465     LYS B    90                                                      
REMARK 465     LYS B    91                                                      
REMARK 465     ILE B    92                                                      
REMARK 465     GLN B    93                                                      
REMARK 465     GLN B    94                                                      
REMARK 465     HIS B    95                                                      
REMARK 465     ASN B    96                                                      
REMARK 465     THR B    97                                                      
REMARK 465     ILE B    98                                                      
REMARK 465     LEU B    99                                                      
REMARK 465     ASN B   100                                                      
REMARK 465     SER B   101                                                      
REMARK 465     SER B   102                                                      
REMARK 465     SER B   103                                                      
REMARK 465     ASP B   104                                                      
REMARK 465     PHE B   105                                                      
REMARK 465     ARG B   106                                                      
REMARK 465     LEU B   107                                                      
REMARK 465     HIS B   108                                                      
REMARK 465     TYR B   109                                                      
REMARK 465     TYR B   110                                                      
REMARK 465     PRO B   111                                                      
REMARK 465     LYS B   112                                                      
REMARK 465     ASP B   113                                                      
REMARK 465     PRO B   114                                                      
REMARK 465     SER B   115                                                      
REMARK 465     ASN B   116                                                      
REMARK 465     VAL B   117                                                      
REMARK 465     GLU B   118                                                      
REMARK 465     THR B   119                                                      
REMARK 465     TYR B   120                                                      
REMARK 465     GLU B   121                                                      
REMARK 465     GLN B   122                                                      
REMARK 465     ILE B   123                                                      
REMARK 465     LEU B   124                                                      
REMARK 465     GLN B   125                                                      
REMARK 465     TRP B   126                                                      
REMARK 465     VAL B   127                                                      
REMARK 465     THR B   128                                                      
REMARK 465     GLU B   129                                                      
REMARK 465     VAL B   130                                                      
REMARK 465     LEU B   131                                                      
REMARK 465     GLY B   132                                                      
REMARK 465     ASN B   133                                                      
REMARK 465     ASP B   134                                                      
REMARK 465     ILE B   135                                                      
REMARK 465     PRO B   136                                                      
REMARK 465     HIS B   137                                                      
REMARK 465     ASP B   138                                                      
REMARK 465     LEU B   139                                                      
REMARK 465     ILE B   140                                                      
REMARK 465     ILE B   141                                                      
REMARK 465     GLY B   142                                                      
REMARK 465     THR B   143                                                      
REMARK 465     ALA B   144                                                      
REMARK 465     ASP B   145                                                      
REMARK 465     ILE B   146                                                      
REMARK 465     PHE B   147                                                      
REMARK 465     ILE B   148                                                      
REMARK 465     ARG B   149                                                      
REMARK 465     GLN B   150                                                      
REMARK 465     LEU B   151                                                      
REMARK 465     LYS B   152                                                      
REMARK 465     GLU B   153                                                      
REMARK 465     ASN B   154                                                      
REMARK 465     GLU B   155                                                      
REMARK 465     GLU B   156                                                      
REMARK 465     ASN B   157                                                      
REMARK 465     GLU B   158                                                      
REMARK 465     ASP B   159                                                      
REMARK 465     GLY B   160                                                      
REMARK 465     ASN B   161                                                      
REMARK 465     ILE B   162                                                      
REMARK 465     GLU B   163                                                      
REMARK 465     GLU B   164                                                      
REMARK 465     ARG B   165                                                      
REMARK 465     LYS B   166                                                      
REMARK 465     GLU B   167                                                      
REMARK 465     LYS B   168                                                      
REMARK 465     ILE B   169                                                      
REMARK 465     GLN B   170                                                      
REMARK 465     HIS B   171                                                      
REMARK 465     GLU B   172                                                      
REMARK 465     LEU B   173                                                      
REMARK 465     GLY B   174                                                      
REMARK 465     ILE B   175                                                      
REMARK 465     ASN B   176                                                      
REMARK 465     ILE B   177                                                      
REMARK 465     ASP B   178                                                      
REMARK 465     SER B   179                                                      
REMARK 465     LEU B   180                                                      
REMARK 465     LYS B   181                                                      
REMARK 465     PHE B   182                                                      
REMARK 465     ASN B   183                                                      
REMARK 465     GLU B   184                                                      
REMARK 465     LEU B   185                                                      
REMARK 465     VAL B   186                                                      
REMARK 465     LYS B   187                                                      
REMARK 465     LEU B   188                                                      
REMARK 465     MET B   189                                                      
REMARK 465     LYS B   190                                                      
REMARK 465     ASN B   191                                                      
REMARK 465     ILE B   192                                                      
REMARK 465     THR B   193                                                      
REMARK 465     ASP B   194                                                      
REMARK 465     TYR B   195                                                      
REMARK 465     GLU B   196                                                      
REMARK 465     THR B   197                                                      
REMARK 465     HIS B   198                                                      
REMARK 465     PRO B   199                                                      
REMARK 465     ASP B   200                                                      
REMARK 465     ASN B   201                                                      
REMARK 465     SER B   202                                                      
REMARK 465     ASN B   203                                                      
REMARK 465     LYS B   204                                                      
REMARK 465     GLN B   205                                                      
REMARK 465     ALA B   206                                                      
REMARK 465     VAL B   207                                                      
REMARK 465     ALA B   208                                                      
REMARK 465     ILE B   209                                                      
REMARK 465     LEU B   210                                                      
REMARK 465     ALA B   211                                                      
REMARK 465     ASP B   212                                                      
REMARK 465     ASP B   213                                                      
REMARK 465     GLU B   214                                                      
REMARK 465     LYS B   215                                                      
REMARK 465     SER B   216                                                      
REMARK 465     ASP B   217                                                      
REMARK 465     GLU B   218                                                      
REMARK 465     GLU B   219                                                      
REMARK 465     GLU B   220                                                      
REMARK 465     VAL B   221                                                      
REMARK 465     THR B   222                                                      
REMARK 465     GLU B   223                                                      
REMARK 465     MET B   224                                                      
REMARK 465     SER B   225                                                      
REMARK 465     ASN B   226                                                      
REMARK 465     ASN B   227                                                      
REMARK 465     ALA B   228                                                      
REMARK 465     ASN B   229                                                      
REMARK 465     VAL B   230                                                      
REMARK 465     LEU B   231                                                      
REMARK 465     GLY B   232                                                      
REMARK 465     GLY B   233                                                      
REMARK 465     GLU B   234                                                      
REMARK 465     ILE B   235                                                      
REMARK 465     ASN B   236                                                      
REMARK 465     ASP B   237                                                      
REMARK 465     ASN B   238                                                      
REMARK 465     GLU B   239                                                      
REMARK 465     ASP B   240                                                      
REMARK 465     ASP B   241                                                      
REMARK 465     ASP B   242                                                      
REMARK 465     GLU B   243                                                      
REMARK 465     GLU B   244                                                      
REMARK 465     TYR B   245                                                      
REMARK 465     ASP B   246                                                      
REMARK 465     TYR B   247                                                      
REMARK 465     ASN B   248                                                      
REMARK 465     ASP B   249                                                      
REMARK 465     VAL B   250                                                      
REMARK 465     GLU B   251                                                      
REMARK 465     VAL B   252                                                      
REMARK 465     ASN B   253                                                      
REMARK 465     SER B   254                                                      
REMARK 465     LYS B   255                                                      
REMARK 465     LYS B   256                                                      
REMARK 465     LYS B   257                                                      
REMARK 465     ASN B   258                                                      
REMARK 465     LYS B   259                                                      
REMARK 465     ARG B   260                                                      
REMARK 465     ALA B   261                                                      
REMARK 465     LEU B   262                                                      
REMARK 465     PRO B   263                                                      
REMARK 465     ASN B   264                                                      
REMARK 465     ILE B   265                                                      
REMARK 465     GLU B   266                                                      
REMARK 465     ASN B   267                                                      
REMARK 465     ASP B   268                                                      
REMARK 465     ILE B   269                                                      
REMARK 465     ILE B   270                                                      
REMARK 465     LYS B   271                                                      
REMARK 465     LEU B   272                                                      
REMARK 465     SER B   273                                                      
REMARK 465     ASP B   274                                                      
REMARK 465     SER B   275                                                      
REMARK 465     LYS B   276                                                      
REMARK 465     THR B   277                                                      
REMARK 465     SER B   278                                                      
REMARK 465     ASN B   279                                                      
REMARK 465     ILE B   280                                                      
REMARK 465     GLU B   281                                                      
REMARK 465     SER B   282                                                      
REMARK 465     VAL B   283                                                      
REMARK 465     PRO B   284                                                      
REMARK 465     ILE B   285                                                      
REMARK 465     TYR B   286                                                      
REMARK 465     SER B   287                                                      
REMARK 465     ILE B   288                                                      
REMARK 465     ASP B   289                                                      
REMARK 465     GLU B   290                                                      
REMARK 465     PHE B   291                                                      
REMARK 465     PHE B   292                                                      
REMARK 465     LEU B   293                                                      
REMARK 465     GLN B   294                                                      
REMARK 465     ARG B   295                                                      
REMARK 465     LYS B   296                                                      
REMARK 465     LEU B   297                                                      
REMARK 465     ARG B   298                                                      
REMARK 465     SER B   299                                                      
REMARK 465     GLU B   300                                                      
REMARK 465     LEU B   301                                                      
REMARK 465     GLY B   302                                                      
REMARK 465     TYR B   303                                                      
REMARK 465     LYS B   304                                                      
REMARK 465     ASP B   305                                                      
REMARK 465     THR B   306                                                      
REMARK 465     SER B   307                                                      
REMARK 465     VAL B   308                                                      
REMARK 465     ILE B   309                                                      
REMARK 465     GLN B   310                                                      
REMARK 465     ASP B   311                                                      
REMARK 465     LEU B   312                                                      
REMARK 465     SER B   313                                                      
REMARK 465     GLU B   314                                                      
REMARK 465     LYS B   315                                                      
REMARK 465     ILE B   316                                                      
REMARK 465     LEU B   317                                                      
REMARK 465     ASN B   318                                                      
REMARK 465     ASP B   319                                                      
REMARK 465     ILE B   320                                                      
REMARK 465     GLU B   321                                                      
REMARK 465     THR B   322                                                      
REMARK 465     LEU B   323                                                      
REMARK 465     GLU B   324                                                      
REMARK 465     HIS B   325                                                      
REMARK 465     ASN B   326                                                      
REMARK 465     PRO B   327                                                      
REMARK 465     VAL B   328                                                      
REMARK 465     ALA B   329                                                      
REMARK 465     LEU B   330                                                      
REMARK 465     GLU B   331                                                      
REMARK 465     GLN B   332                                                      
REMARK 465     LYS B   333                                                      
REMARK 465     LEU B   334                                                      
REMARK 465     VAL B   335                                                      
REMARK 465     ASP B   336                                                      
REMARK 465     LEU B   337                                                      
REMARK 465     LEU B   338                                                      
REMARK 465     LYS B   339                                                      
REMARK 465     PHE B   340                                                      
REMARK 465     GLU B   341                                                      
REMARK 465     ASN B   342                                                      
REMARK 465     ILE B   343                                                      
REMARK 465     SER B   344                                                      
REMARK 465     LEU B   345                                                      
REMARK 465     ALA B   346                                                      
REMARK 465     GLU B   347                                                      
REMARK 465     PHE B   348                                                      
REMARK 465     ILE B   349                                                      
REMARK 465     LEU B   350                                                      
REMARK 465     LYS B   351                                                      
REMARK 465     ASN B   352                                                      
REMARK 465     ARG B   353                                                      
REMARK 465     SER B   354                                                      
REMARK 465     THR B   355                                                      
REMARK 465     ILE B   356                                                      
REMARK 465     PHE B   357                                                      
REMARK 465     TRP B   358                                                      
REMARK 465     GLY B   359                                                      
REMARK 465     ILE B   360                                                      
REMARK 465     ARG B   361                                                      
REMARK 465     LEU B   362                                                      
REMARK 465     ALA B   363                                                      
REMARK 465     LYS B   364                                                      
REMARK 465     SER B   365                                                      
REMARK 465     THR B   366                                                      
REMARK 465     GLU B   367                                                      
REMARK 465     ASN B   368                                                      
REMARK 465     GLU B   369                                                      
REMARK 465     ILE B   370                                                      
REMARK 465     PRO B   371                                                      
REMARK 465     ASN B   372                                                      
REMARK 465     LEU B   373                                                      
REMARK 465     ILE B   374                                                      
REMARK 465     GLU B   375                                                      
REMARK 465     LYS B   376                                                      
REMARK 465     MET B   377                                                      
REMARK 465     VAL B   378                                                      
REMARK 465     ALA B   379                                                      
REMARK 465     LYS B   380                                                      
REMARK 465     GLY B   381                                                      
REMARK 465     LEU B   382                                                      
REMARK 465     ASN B   383                                                      
REMARK 465     ASP B   384                                                      
REMARK 465     LEU B   385                                                      
REMARK 465     VAL B   386                                                      
REMARK 465     GLU B   387                                                      
REMARK 465     GLN B   388                                                      
REMARK 465     TYR B   389                                                      
REMARK 465     LYS B   390                                                      
REMARK 465     PHE B   391                                                      
REMARK 465     ARG B   392                                                      
REMARK 465     GLU B   393                                                      
REMARK 465     THR B   394                                                      
REMARK 465     THR B   395                                                      
REMARK 465     HIS B   396                                                      
REMARK 465     SER B   397                                                      
REMARK 465     LYS B   398                                                      
REMARK 465     ARG B   399                                                      
REMARK 465     GLU B   400                                                      
REMARK 465     LEU B   401                                                      
REMARK 465     ASP B   402                                                      
REMARK 465     SER B   403                                                      
REMARK 465     GLY B   404                                                      
REMARK 465     ASP B   405                                                      
REMARK 465     ASP B   406                                                      
REMARK 465     GLN B   407                                                      
REMARK 465     PRO B   408                                                      
REMARK 465     GLN B   409                                                      
REMARK 465     SER B   410                                                      
REMARK 465     SER B   411                                                      
REMARK 465     GLU B   412                                                      
REMARK 465     ALA B   413                                                      
REMARK 465     LYS B   414                                                      
REMARK 465     ARG B   415                                                      
REMARK 465     THR B   416                                                      
REMARK 465     LYS B   417                                                      
REMARK 465     PHE B   418                                                      
REMARK 465     SER B   419                                                      
REMARK 465     ASN B   420                                                      
REMARK 465     PRO B   421                                                      
REMARK 465     ALA B   422                                                      
REMARK 465     ILE B   423                                                      
REMARK 465     PRO B   424                                                      
REMARK 465     PRO B   425                                                      
REMARK 465     VAL B   426                                                      
REMARK 465     ILE B   427                                                      
REMARK 465     ASP B   428                                                      
REMARK 465     LEU B   429                                                      
REMARK 465     GLU B   430                                                      
REMARK 465     LYS B   431                                                      
REMARK 465     ILE B   432                                                      
REMARK 465     LYS B   433                                                      
REMARK 465     PHE B   434                                                      
REMARK 465     ASP B   435                                                      
REMARK 465     GLU B   436                                                      
REMARK 465     SER B   437                                                      
REMARK 465     SER B   438                                                      
REMARK 465     GLU B  1826                                                      
REMARK 465     ALA B  1827                                                      
REMARK 465     GLU B  1828                                                      
REMARK 465     VAL B  1829                                                      
REMARK 465     THR B  1830                                                      
REMARK 465     ALA B  1831                                                      
REMARK 465     GLU B  1832                                                      
REMARK 465     VAL B  1833                                                      
REMARK 465     ASN B  1834                                                      
REMARK 465     GLY B  1835                                                      
REMARK 465     GLY B  1836                                                      
REMARK 465     ASP B  1837                                                      
REMARK 465     ASP B  1838                                                      
REMARK 465     GLU B  1839                                                      
REMARK 465     ALA B  1840                                                      
REMARK 465       G V    65                                                      
REMARK 465       A V    66                                                      
REMARK 465       A V    67                                                      
REMARK 465       A V    68                                                      
REMARK 465       U V    69                                                      
REMARK 465       U V    70                                                      
REMARK 465       U V    71                                                      
REMARK 465       A V    72                                                      
REMARK 465       U V   105                                                      
REMARK 465       C V   106                                                      
REMARK 465       G V   107                                                      
REMARK 465       G V   108                                                      
REMARK 465       U V   109                                                      
REMARK 465       G V   110                                                      
REMARK 465       U V   111                                                      
REMARK 465       U V   112                                                      
REMARK 465       C V   113                                                      
REMARK 465       G V   114                                                      
REMARK 465       C V   115                                                      
REMARK 465       U V   116                                                      
REMARK 465       U V   117                                                      
REMARK 465       U V   118                                                      
REMARK 465       U V   119                                                      
REMARK 465       G V   120                                                      
REMARK 465       A V   121                                                      
REMARK 465       A V   122                                                      
REMARK 465       U V   123                                                      
REMARK 465       A V   124                                                      
REMARK 465       C V   125                                                      
REMARK 465       U V   126                                                      
REMARK 465       U V   127                                                      
REMARK 465       A V   153                                                      
REMARK 465       U V   154                                                      
REMARK 465       A V   155                                                      
REMARK 465       C V   156                                                      
REMARK 465       C V   157                                                      
REMARK 465       U V   158                                                      
REMARK 465       U V   159                                                      
REMARK 465       U V   160                                                      
REMARK 465     GLU A  2402                                                      
REMARK 465     GLU A  2403                                                      
REMARK 465     LEU A  2404                                                      
REMARK 465     GLU A  2405                                                      
REMARK 465     ALA A  2406                                                      
REMARK 465     GLU A  2407                                                      
REMARK 465     GLN A  2408                                                      
REMARK 465     ILE A  2409                                                      
REMARK 465     ASP A  2410                                                      
REMARK 465     VAL A  2411                                                      
REMARK 465     PHE A  2412                                                      
REMARK 465     SER A  2413                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU k  98    CG   CD   OE1  OE2                                  
REMARK 470     ASP k  99    CG   OD1  OD2                                       
REMARK 470     ASP l  99    CG   OD1  OD2                                       
REMARK 470     GLU m  19    CG   CD   OE1  OE2                                  
REMARK 470     GLU m  20    CG   CD   OE1  OE2                                  
REMARK 470     GLU m  22    CG   CD   OE1  OE2                                  
REMARK 470     GLU m  23    CG   CD   OE1  OE2                                  
REMARK 470     GLU m  25    CG   CD   OE1  OE2                                  
REMARK 470     ASP m  36    CG   OD1  OD2                                       
REMARK 470     GLU m  74    CG   CD   OE1  OE2                                  
REMARK 470     LYS m  79    CG   CD   CE   NZ                                   
REMARK 470     GLU m  88    CG   CD   OE1  OE2                                  
REMARK 470     GLU n  13    CG   CD   OE1  OE2                                  
REMARK 470     ASP n  46    CG   OD1  OD2                                       
REMARK 470     GLU p  56    CG   CD   OE1  OE2                                  
REMARK 470     GLU p  59    CG   CD   OE1  OE2                                  
REMARK 470     LYS p  73    CG   CD   CE   NZ                                   
REMARK 470     GLU q  37    CG   CD   OE1  OE2                                  
REMARK 470     GLU r   6    CG   CD   OE1  OE2                                  
REMARK 470     ASP r  41    CG   OD1  OD2                                       
REMARK 470     ASP r  42    CG   OD1  OD2                                       
REMARK 470     GLU B 450    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 851    CG   OD1  OD2                                       
REMARK 470     ASP B1553    CG   OD1  OD2                                       
REMARK 470     GLU B1555    CG   CD   OE1  OE2                                  
REMARK 470     GLU A2316    CG   CD   OE1  OE2                                  
REMARK 470     GLU A2317    CG   CD   OE1  OE2                                  
REMARK 470     GLU A2327    CG   CD   OE1  OE2                                  
REMARK 470     GLU A2330    CG   CD   OE1  OE2                                  
REMARK 470     GLU A2397    CG   CD   OE1  OE2                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    VAL k  81       84.09   -161.13                                   
REMARK 500    LEU k  93      -65.48   -102.89                                   
REMARK 500    ASP k  99      117.19   -162.89                                   
REMARK 500    ASN l  12       70.60     65.13                                   
REMARK 500    GLN l  30     -130.11     55.50                                   
REMARK 500    ARG l  93      -66.57    -96.79                                   
REMARK 500    SER l 100       78.18   -106.52                                   
REMARK 500    ASP l 104      -77.04   -132.02                                   
REMARK 500    LEU l 106      -49.88   -154.04                                   
REMARK 500    ARG m  41      119.77    -33.90                                   
REMARK 500    LYS m  59      -56.72   -134.53                                   
REMARK 500    ASP m  62     -168.81   -122.84                                   
REMARK 500    ASN m  66       83.44    -63.68                                   
REMARK 500    ASN m  86       90.08    -64.80                                   
REMARK 500    LYS m  93       60.54     61.74                                   
REMARK 500    ILE m 102      -66.65   -122.50                                   
REMARK 500    ARG n  30       99.59   -164.61                                   
REMARK 500    ALA n  55       84.85    -67.94                                   
REMARK 500    LYS n  79      -62.21   -107.44                                   
REMARK 500    GLN p  24       71.15     66.02                                   
REMARK 500    PHE p  32      -71.22    -95.43                                   
REMARK 500    GLU p  33      -73.15    -55.17                                   
REMARK 500    VAL p  44      -54.56   -120.37                                   
REMARK 500    LYS q  32      -90.13    -87.35                                   
REMARK 500    ASN q  34       63.45     65.06                                   
REMARK 500    VAL q  43      -64.14   -123.90                                   
REMARK 500    PHE q  49       31.82     76.42                                   
REMARK 500    GLU q  58       78.06   -102.51                                   
REMARK 500    LEU r  36       14.58     84.46                                   
REMARK 500    ASN r  37       91.76    -69.86                                   
REMARK 500    LEU r  59      -90.89    -78.43                                   
REMARK 500    ILE r  69      -64.61   -121.57                                   
REMARK 500    ALA E  56       48.12   -155.59                                   
REMARK 500    ALA E  90       56.81   -150.66                                   
REMARK 500    ALA E 101      -83.46     57.53                                   
REMARK 500    ALA E 125       53.66   -116.94                                   
REMARK 500    ALA E 131       69.48   -167.19                                   
REMARK 500    ALA E 153       43.36   -107.97                                   
REMARK 500    ALA E 155       27.84   -144.06                                   
REMARK 500    ALA E 164       40.52   -107.97                                   
REMARK 500    ALA E 211       41.80   -157.98                                   
REMARK 500    ALA E 212      -60.92   -164.56                                   
REMARK 500    ALA E 225       48.54   -159.06                                   
REMARK 500    ALA E 242       44.73    -96.55                                   
REMARK 500    ALA E 248       80.61    -67.30                                   
REMARK 500    ALA E 271       49.69   -102.62                                   
REMARK 500    ALA E 278      -50.39   -154.06                                   
REMARK 500    ALA E 291       30.29   -151.91                                   
REMARK 500    ALA E 315       33.96    -94.86                                   
REMARK 500    ALA E 331       51.25   -113.96                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     182 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 LEU k   84     THR k   85                 -147.77                    
REMARK 500 ASP B  790     PRO B  791                 -146.17                    
REMARK 500 PRO B  791     SER B  792                 -144.74                    
REMARK 500 PRO B 1200     LYS B 1201                 -147.47                    
REMARK 500 TYR B 1484     GLY B 1485                  148.71                    
REMARK 500 ASN B 1517     ALA B 1518                 -145.58                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8013   RELATED DB: EMDB                              
DBREF  5GAO k    1   196  UNP    P40018   RSMB_YEAST       1    196             
DBREF  5GAO l    1   146  UNP    Q02260   SMD1_YEAST       1    146             
DBREF  5GAO m    1   110  UNP    Q06217   SMD2_YEAST       1    110             
DBREF  5GAO n    1   101  UNP    P43321   SMD3_YEAST       1    101             
DBREF  5GAO p    1    94  UNP    Q12330   RUXE_YEAST       1     94             
DBREF  5GAO q    1    86  UNP    P54999   RUXF_YEAST       1     86             
DBREF  5GAO r    1    77  UNP    P40204   RUXG_YEAST       1     77             
DBREF  5GAO E    5   560  PDB    5GAO     5GAO             5    560             
DBREF  5GAO B    1  2163  UNP    P32639   BRR2_YEAST       1   2163             
DBREF1 5GAO V   65   160  GB                   CP011083.1                       
DBREF2 5GAO V     807071957                      164431      164336             
DBREF  5GAO A 2147  2413  UNP    P33334   PRP8_YEAST    2147   2413             
SEQRES   1 k  196  MET SER LYS ILE GLN VAL ALA HIS SER SER ARG LEU ALA          
SEQRES   2 k  196  ASN LEU ILE ASP TYR LYS LEU ARG VAL LEU THR GLN ASP          
SEQRES   3 k  196  GLY ARG VAL TYR ILE GLY GLN LEU MET ALA PHE ASP LYS          
SEQRES   4 k  196  HIS MET ASN LEU VAL LEU ASN GLU CYS ILE GLU GLU ARG          
SEQRES   5 k  196  VAL PRO LYS THR GLN LEU ASP LYS LEU ARG PRO ARG LYS          
SEQRES   6 k  196  ASP SER LYS ASP GLY THR THR LEU ASN ILE LYS VAL GLU          
SEQRES   7 k  196  LYS ARG VAL LEU GLY LEU THR ILE LEU ARG GLY GLU GLN          
SEQRES   8 k  196  ILE LEU SER THR VAL VAL GLU ASP LYS PRO LEU LEU SER          
SEQRES   9 k  196  LYS LYS GLU ARG LEU VAL ARG ASP LYS LYS GLU LYS LYS          
SEQRES  10 k  196  GLN ALA GLN LYS GLN THR LYS LEU ARG LYS GLU LYS GLU          
SEQRES  11 k  196  LYS LYS PRO GLY LYS ILE ALA LYS PRO ASN THR ALA ASN          
SEQRES  12 k  196  ALA LYS HIS THR SER SER ASN SER ARG GLU ILE ALA GLN          
SEQRES  13 k  196  PRO SER SER SER ARG TYR ASN GLY GLY ASN ASP ASN ILE          
SEQRES  14 k  196  GLY ALA ASN ARG SER ARG PHE ASN ASN GLU ALA PRO PRO          
SEQRES  15 k  196  GLN THR ARG LYS PHE GLN PRO PRO PRO GLY PHE LYS ARG          
SEQRES  16 k  196  LYS                                                          
SEQRES   1 l  146  MET LYS LEU VAL ASN PHE LEU LYS LYS LEU ARG ASN GLU          
SEQRES   2 l  146  GLN VAL THR ILE GLU LEU LYS ASN GLY THR THR VAL TRP          
SEQRES   3 l  146  GLY THR LEU GLN SER VAL SER PRO GLN MET ASN ALA ILE          
SEQRES   4 l  146  LEU THR ASP VAL LYS LEU THR LEU PRO GLN PRO ARG LEU          
SEQRES   5 l  146  ASN LYS LEU ASN SER ASN GLY ILE ALA MET ALA SER LEU          
SEQRES   6 l  146  TYR LEU THR GLY GLY GLN GLN PRO THR ALA SER ASP ASN          
SEQRES   7 l  146  ILE ALA SER LEU GLN TYR ILE ASN ILE ARG GLY ASN THR          
SEQRES   8 l  146  ILE ARG GLN ILE ILE LEU PRO ASP SER LEU ASN LEU ASP          
SEQRES   9 l  146  SER LEU LEU VAL ASP GLN LYS GLN LEU ASN SER LEU ARG          
SEQRES  10 l  146  ARG SER GLY GLN ILE ALA ASN ASP PRO SER LYS LYS ARG          
SEQRES  11 l  146  ARG ARG ASP PHE GLY ALA PRO ALA ASN LYS ARG PRO ARG          
SEQRES  12 l  146  ARG GLY LEU                                                  
SEQRES   1 m  110  MET SER SER GLN ILE ILE ASP ARG PRO LYS HIS GLU LEU          
SEQRES   2 m  110  SER ARG ALA GLU LEU GLU GLU LEU GLU GLU PHE GLU PHE          
SEQRES   3 m  110  LYS HIS GLY PRO MET SER LEU ILE ASN ASP ALA MET VAL          
SEQRES   4 m  110  THR ARG THR PRO VAL ILE ILE SER LEU ARG ASN ASN HIS          
SEQRES   5 m  110  LYS ILE ILE ALA ARG VAL LYS ALA PHE ASP ARG HIS CYS          
SEQRES   6 m  110  ASN MET VAL LEU GLU ASN VAL LYS GLU LEU TRP THR GLU          
SEQRES   7 m  110  LYS LYS GLY LYS ASN VAL ILE ASN ARG GLU ARG PHE ILE          
SEQRES   8 m  110  SER LYS LEU PHE LEU ARG GLY ASP SER VAL ILE VAL VAL          
SEQRES   9 m  110  LEU LYS THR PRO VAL GLU                                      
SEQRES   1 n  101  MET THR MET ASN GLY ILE PRO VAL LYS LEU LEU ASN GLU          
SEQRES   2 n  101  ALA GLN GLY HIS ILE VAL SER LEU GLU LEU THR THR GLY          
SEQRES   3 n  101  ALA THR TYR ARG GLY LYS LEU VAL GLU SER GLU ASP SER          
SEQRES   4 n  101  MET ASN VAL GLN LEU ARG ASP VAL ILE ALA THR GLU PRO          
SEQRES   5 n  101  GLN GLY ALA VAL THR HIS MET ASP GLN ILE PHE VAL ARG          
SEQRES   6 n  101  GLY SER GLN ILE LYS PHE ILE VAL VAL PRO ASP LEU LEU          
SEQRES   7 n  101  LYS ASN ALA PRO LEU PHE LYS LYS ASN SER SER ARG PRO          
SEQRES   8 n  101  MET PRO PRO ILE ARG GLY PRO LYS ARG ARG                      
SEQRES   1 p   94  MET SER ASN LYS VAL LYS THR LYS ALA MET VAL PRO PRO          
SEQRES   2 p   94  ILE ASN CYS ILE PHE ASN PHE LEU GLN GLN GLN THR PRO          
SEQRES   3 p   94  VAL THR ILE TRP LEU PHE GLU GLN ILE GLY ILE ARG ILE          
SEQRES   4 p   94  LYS GLY LYS ILE VAL GLY PHE ASP GLU PHE MET ASN VAL          
SEQRES   5 p   94  VAL ILE ASP GLU ALA VAL GLU ILE PRO VAL ASN SER ALA          
SEQRES   6 p   94  ASP GLY LYS GLU ASP VAL GLU LYS GLY THR PRO LEU GLY          
SEQRES   7 p   94  LYS ILE LEU LEU LYS GLY ASP ASN ILE THR LEU ILE THR          
SEQRES   8 p   94  SER ALA ASP                                                  
SEQRES   1 q   86  MET SER GLU SER SER ASP ILE SER ALA MET GLN PRO VAL          
SEQRES   2 q   86  ASN PRO LYS PRO PHE LEU LYS GLY LEU VAL ASN HIS ARG          
SEQRES   3 q   86  VAL GLY VAL LYS LEU LYS PHE ASN SER THR GLU TYR ARG          
SEQRES   4 q   86  GLY THR LEU VAL SER THR ASP ASN TYR PHE ASN LEU GLN          
SEQRES   5 q   86  LEU ASN GLU ALA GLU GLU PHE VAL ALA GLY VAL SER HIS          
SEQRES   6 q   86  GLY THR LEU GLY GLU ILE PHE ILE ARG CYS ASN ASN VAL          
SEQRES   7 q   86  LEU TYR ILE ARG GLU LEU PRO ASN                              
SEQRES   1 r   77  MET VAL SER THR PRO GLU LEU LYS LYS TYR MET ASP LYS          
SEQRES   2 r   77  LYS ILE LEU LEU ASN ILE ASN GLY SER ARG LYS VAL ALA          
SEQRES   3 r   77  GLY ILE LEU ARG GLY TYR ASP ILE PHE LEU ASN VAL VAL          
SEQRES   4 r   77  LEU ASP ASP ALA MET GLU ILE ASN GLY GLU ASP PRO ALA          
SEQRES   5 r   77  ASN ASN HIS GLN LEU GLY LEU GLN THR VAL ILE ARG GLY          
SEQRES   6 r   77  ASN SER ILE ILE SER LEU GLU ALA LEU ASP ALA ILE              
SEQRES   1 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES   2 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES   3 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES   4 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES   5 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES   6 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES   7 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES   8 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES   9 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  10 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  11 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  12 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  13 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  14 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  15 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  16 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  17 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  18 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  19 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  20 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  21 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ARG ALA ALA ALA          
SEQRES  22 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  23 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  24 E  338  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES  25 E  338  ALA ALA ALA ALA ALA THR THR LYS GLU ALA TYR LYS LYS          
SEQRES  26 E  338  LEU SER GLN LYS PHE HIS GLY THR LYS SER ASN LYS LYS          
SEQRES   1 B 2163  MET THR GLU HIS GLU THR LYS ASP LYS ALA LYS LYS ILE          
SEQRES   2 B 2163  ARG GLU ILE TYR ARG TYR ASP GLU MET SER ASN LYS VAL          
SEQRES   3 B 2163  LEU LYS VAL ASP LYS ARG PHE MET ASN THR SER GLN ASN          
SEQRES   4 B 2163  PRO GLN ARG ASP ALA GLU ILE SER GLN PRO LYS SER MET          
SEQRES   5 B 2163  SER GLY ARG ILE SER ALA LYS ASP MET GLY GLN GLY LEU          
SEQRES   6 B 2163  CYS ASN ASN ILE ASN LYS GLY LEU LYS GLU ASN ASP VAL          
SEQRES   7 B 2163  ALA VAL GLU LYS THR GLY LYS SER ALA SER LEU LYS LYS          
SEQRES   8 B 2163  ILE GLN GLN HIS ASN THR ILE LEU ASN SER SER SER ASP          
SEQRES   9 B 2163  PHE ARG LEU HIS TYR TYR PRO LYS ASP PRO SER ASN VAL          
SEQRES  10 B 2163  GLU THR TYR GLU GLN ILE LEU GLN TRP VAL THR GLU VAL          
SEQRES  11 B 2163  LEU GLY ASN ASP ILE PRO HIS ASP LEU ILE ILE GLY THR          
SEQRES  12 B 2163  ALA ASP ILE PHE ILE ARG GLN LEU LYS GLU ASN GLU GLU          
SEQRES  13 B 2163  ASN GLU ASP GLY ASN ILE GLU GLU ARG LYS GLU LYS ILE          
SEQRES  14 B 2163  GLN HIS GLU LEU GLY ILE ASN ILE ASP SER LEU LYS PHE          
SEQRES  15 B 2163  ASN GLU LEU VAL LYS LEU MET LYS ASN ILE THR ASP TYR          
SEQRES  16 B 2163  GLU THR HIS PRO ASP ASN SER ASN LYS GLN ALA VAL ALA          
SEQRES  17 B 2163  ILE LEU ALA ASP ASP GLU LYS SER ASP GLU GLU GLU VAL          
SEQRES  18 B 2163  THR GLU MET SER ASN ASN ALA ASN VAL LEU GLY GLY GLU          
SEQRES  19 B 2163  ILE ASN ASP ASN GLU ASP ASP ASP GLU GLU TYR ASP TYR          
SEQRES  20 B 2163  ASN ASP VAL GLU VAL ASN SER LYS LYS LYS ASN LYS ARG          
SEQRES  21 B 2163  ALA LEU PRO ASN ILE GLU ASN ASP ILE ILE LYS LEU SER          
SEQRES  22 B 2163  ASP SER LYS THR SER ASN ILE GLU SER VAL PRO ILE TYR          
SEQRES  23 B 2163  SER ILE ASP GLU PHE PHE LEU GLN ARG LYS LEU ARG SER          
SEQRES  24 B 2163  GLU LEU GLY TYR LYS ASP THR SER VAL ILE GLN ASP LEU          
SEQRES  25 B 2163  SER GLU LYS ILE LEU ASN ASP ILE GLU THR LEU GLU HIS          
SEQRES  26 B 2163  ASN PRO VAL ALA LEU GLU GLN LYS LEU VAL ASP LEU LEU          
SEQRES  27 B 2163  LYS PHE GLU ASN ILE SER LEU ALA GLU PHE ILE LEU LYS          
SEQRES  28 B 2163  ASN ARG SER THR ILE PHE TRP GLY ILE ARG LEU ALA LYS          
SEQRES  29 B 2163  SER THR GLU ASN GLU ILE PRO ASN LEU ILE GLU LYS MET          
SEQRES  30 B 2163  VAL ALA LYS GLY LEU ASN ASP LEU VAL GLU GLN TYR LYS          
SEQRES  31 B 2163  PHE ARG GLU THR THR HIS SER LYS ARG GLU LEU ASP SER          
SEQRES  32 B 2163  GLY ASP ASP GLN PRO GLN SER SER GLU ALA LYS ARG THR          
SEQRES  33 B 2163  LYS PHE SER ASN PRO ALA ILE PRO PRO VAL ILE ASP LEU          
SEQRES  34 B 2163  GLU LYS ILE LYS PHE ASP GLU SER SER LYS LEU MET THR          
SEQRES  35 B 2163  VAL THR LYS VAL SER LEU PRO GLU GLY SER PHE LYS ARG          
SEQRES  36 B 2163  VAL LYS PRO GLN TYR ASP GLU ILE HIS ILE PRO ALA PRO          
SEQRES  37 B 2163  SER LYS PRO VAL ILE ASP TYR GLU LEU LYS GLU ILE THR          
SEQRES  38 B 2163  SER LEU PRO ASP TRP CYS GLN GLU ALA PHE PRO SER SER          
SEQRES  39 B 2163  GLU THR THR SER LEU ASN PRO ILE GLN SER LYS VAL PHE          
SEQRES  40 B 2163  HIS ALA ALA PHE GLU GLY ASP SER ASN MET LEU ILE CYS          
SEQRES  41 B 2163  ALA PRO THR GLY SER GLY LYS THR ASN ILE ALA LEU LEU          
SEQRES  42 B 2163  THR VAL LEU LYS ALA LEU SER HIS HIS TYR ASN PRO LYS          
SEQRES  43 B 2163  THR LYS LYS LEU ASN LEU SER ALA PHE LYS ILE VAL TYR          
SEQRES  44 B 2163  ILE ALA PRO LEU LYS ALA LEU VAL GLN GLU GLN VAL ARG          
SEQRES  45 B 2163  GLU PHE GLN ARG ARG LEU ALA PHE LEU GLY ILE LYS VAL          
SEQRES  46 B 2163  ALA GLU LEU THR GLY ASP SER ARG LEU SER ARG LYS GLN          
SEQRES  47 B 2163  ILE ASP GLU THR GLN VAL LEU VAL SER THR PRO GLU LYS          
SEQRES  48 B 2163  TRP ASP ILE THR THR ARG ASN SER ASN ASN LEU ALA ILE          
SEQRES  49 B 2163  VAL GLU LEU VAL ARG LEU LEU ILE ILE ASP GLU ILE HIS          
SEQRES  50 B 2163  LEU LEU HIS ASP ASP ARG GLY PRO VAL LEU GLU SER ILE          
SEQRES  51 B 2163  VAL ALA ARG THR PHE TRP ALA SER LYS TYR GLY GLN GLU          
SEQRES  52 B 2163  TYR PRO ARG ILE ILE GLY LEU SER ALA THR LEU PRO ASN          
SEQRES  53 B 2163  TYR GLU ASP VAL GLY ARG PHE LEU ARG VAL PRO LYS GLU          
SEQRES  54 B 2163  GLY LEU PHE TYR PHE ASP SER SER PHE ARG PRO CYS PRO          
SEQRES  55 B 2163  LEU SER GLN GLN PHE CYS GLY ILE LYS GLU ARG ASN SER          
SEQRES  56 B 2163  LEU LYS LYS LEU LYS ALA MET ASN ASP ALA CYS TYR GLU          
SEQRES  57 B 2163  LYS VAL LEU GLU SER ILE ASN GLU GLY ASN GLN ILE ILE          
SEQRES  58 B 2163  VAL PHE VAL HIS SER ARG LYS GLU THR SER ARG THR ALA          
SEQRES  59 B 2163  THR TRP LEU LYS ASN LYS PHE ALA GLU GLU ASN ILE THR          
SEQRES  60 B 2163  HIS LYS LEU THR LYS ASN ASP ALA GLY SER LYS GLN ILE          
SEQRES  61 B 2163  LEU LYS THR GLU ALA ALA ASN VAL LEU ASP PRO SER LEU          
SEQRES  62 B 2163  ARG LYS LEU ILE GLU SER GLY ILE GLY THR HIS HIS ALA          
SEQRES  63 B 2163  GLY LEU THR ARG SER ASP ARG SER LEU SER GLU ASP LEU          
SEQRES  64 B 2163  PHE ALA ASP GLY LEU LEU GLN VAL LEU VAL CYS THR ALA          
SEQRES  65 B 2163  THR LEU ALA TRP GLY VAL ASN LEU PRO ALA HIS THR VAL          
SEQRES  66 B 2163  ILE ILE LYS GLY THR ASP VAL TYR SER PRO GLU LYS GLY          
SEQRES  67 B 2163  SER TRP GLU GLN LEU SER PRO GLN ASP VAL LEU GLN MET          
SEQRES  68 B 2163  LEU GLY ARG ALA GLY ARG PRO ARG TYR ASP THR PHE GLY          
SEQRES  69 B 2163  GLU GLY ILE ILE ILE THR ASP GLN SER ASN VAL GLN TYR          
SEQRES  70 B 2163  TYR LEU SER VAL LEU ASN GLN GLN LEU PRO ILE GLU SER          
SEQRES  71 B 2163  GLN PHE VAL SER LYS LEU VAL ASP ASN LEU ASN ALA GLU          
SEQRES  72 B 2163  VAL VAL ALA GLY ASN ILE LYS CYS ARG ASN ASP ALA VAL          
SEQRES  73 B 2163  ASN TRP LEU ALA TYR THR TYR LEU TYR VAL ARG MET LEU          
SEQRES  74 B 2163  ALA SER PRO MET LEU TYR LYS VAL PRO ASP ILE SER SER          
SEQRES  75 B 2163  ASP GLY GLN LEU LYS LYS PHE ARG GLU SER LEU VAL HIS          
SEQRES  76 B 2163  SER ALA LEU CYS ILE LEU LYS GLU GLN GLU LEU VAL LEU          
SEQRES  77 B 2163  TYR ASP ALA GLU ASN ASP VAL ILE GLU ALA THR ASP LEU          
SEQRES  78 B 2163  GLY ASN ILE ALA SER SER PHE TYR ILE ASN HIS ALA SER          
SEQRES  79 B 2163  MET ASP VAL TYR ASN ARG GLU LEU ASP GLU HIS THR THR          
SEQRES  80 B 2163  GLN ILE ASP LEU PHE ARG ILE PHE SER MET SER GLU GLU          
SEQRES  81 B 2163  PHE LYS TYR VAL SER VAL ARG TYR GLU GLU LYS ARG GLU          
SEQRES  82 B 2163  LEU LYS GLN LEU LEU GLU LYS ALA PRO ILE PRO ILE ARG          
SEQRES  83 B 2163  GLU ASP ILE ASP ASP PRO LEU ALA LYS VAL ASN VAL LEU          
SEQRES  84 B 2163  LEU GLN SER TYR PHE SER GLN LEU LYS PHE GLU GLY PHE          
SEQRES  85 B 2163  ALA LEU ASN SER ASP ILE VAL PHE ILE HIS GLN ASN ALA          
SEQRES  86 B 2163  GLY ARG LEU LEU ARG ALA MET PHE GLU ILE CYS LEU LYS          
SEQRES  87 B 2163  ARG GLY TRP GLY HIS PRO THR ARG MET LEU LEU ASN LEU          
SEQRES  88 B 2163  CYS LYS SER ALA THR THR LYS MET TRP PRO THR ASN CYS          
SEQRES  89 B 2163  PRO LEU ARG GLN PHE LYS THR CYS PRO VAL GLU VAL ILE          
SEQRES  90 B 2163  LYS ARG LEU GLU ALA SER THR VAL PRO TRP GLY ASP TYR          
SEQRES  91 B 2163  LEU GLN LEU GLU THR PRO ALA GLU VAL GLY ARG ALA ILE          
SEQRES  92 B 2163  ARG SER GLU LYS TYR GLY LYS GLN VAL TYR ASP LEU LEU          
SEQRES  93 B 2163  LYS ARG PHE PRO LYS MET SER VAL THR CYS ASN ALA GLN          
SEQRES  94 B 2163  PRO ILE THR ARG SER VAL MET ARG PHE ASN ILE GLU ILE          
SEQRES  95 B 2163  ILE ALA ASP TRP ILE TRP ASP MET ASN VAL HIS GLY SER          
SEQRES  96 B 2163  LEU GLU PRO PHE LEU LEU MET LEU GLU ASP THR ASP GLY          
SEQRES  97 B 2163  ASP SER ILE LEU TYR TYR ASP VAL LEU PHE ILE THR PRO          
SEQRES  98 B 2163  ASP ILE VAL GLY HIS GLU PHE THR LEU SER PHE THR TYR          
SEQRES  99 B 2163  GLU LEU LYS GLN HIS ASN GLN ASN ASN LEU PRO PRO ASN          
SEQRES 100 B 2163  PHE PHE LEU THR LEU ILE SER GLU ASN TRP TRP HIS SER          
SEQRES 101 B 2163  GLU PHE GLU ILE PRO VAL SER PHE ASN GLY PHE LYS LEU          
SEQRES 102 B 2163  PRO LYS LYS PHE PRO PRO PRO THR PRO LEU LEU GLU ASN          
SEQRES 103 B 2163  ILE SER ILE SER THR SER GLU LEU GLY ASN ASP ASP PHE          
SEQRES 104 B 2163  SER GLU VAL PHE GLU PHE LYS THR PHE ASN LYS ILE GLN          
SEQRES 105 B 2163  SER GLN VAL PHE GLU SER LEU TYR ASN SER ASN ASP SER          
SEQRES 106 B 2163  VAL PHE VAL GLY SER GLY LYS GLY THR GLY LYS THR ALA          
SEQRES 107 B 2163  MET ALA GLU LEU ALA LEU LEU ASN HIS TRP ARG GLN ASN          
SEQRES 108 B 2163  LYS GLY ARG ALA VAL TYR ILE ASN PRO SER GLY GLU LYS          
SEQRES 109 B 2163  ILE ASP PHE LEU LEU SER ASP TRP ASN LYS ARG PHE SER          
SEQRES 110 B 2163  HIS LEU ALA GLY GLY LYS ILE ILE ASN LYS LEU GLY ASN          
SEQRES 111 B 2163  ASP PRO SER LEU ASN LEU LYS LEU LEU ALA LYS SER HIS          
SEQRES 112 B 2163  VAL LEU LEU ALA THR PRO VAL GLN PHE GLU LEU LEU SER          
SEQRES 113 B 2163  ARG ARG TRP ARG GLN ARG LYS ASN ILE GLN SER LEU GLU          
SEQRES 114 B 2163  LEU MET ILE TYR ASP ASP ALA HIS GLU ILE SER GLN GLY          
SEQRES 115 B 2163  VAL TYR GLY ALA VAL TYR GLU THR LEU ILE SER ARG MET          
SEQRES 116 B 2163  ILE PHE ILE ALA THR GLN LEU GLU LYS LYS ILE ARG PHE          
SEQRES 117 B 2163  VAL CYS LEU SER ASN CYS LEU ALA ASN ALA ARG ASP PHE          
SEQRES 118 B 2163  GLY GLU TRP ALA GLY MET THR LYS SER ASN ILE TYR ASN          
SEQRES 119 B 2163  PHE SER PRO SER GLU ARG ILE GLU PRO LEU GLU ILE ASN          
SEQRES 120 B 2163  ILE GLN SER PHE LYS ASP VAL GLU HIS ILE SER PHE ASN          
SEQRES 121 B 2163  PHE SER MET LEU GLN MET ALA PHE GLU ALA SER ALA ALA          
SEQRES 122 B 2163  ALA ALA GLY ASN ARG ASN SER SER SER VAL PHE LEU PRO          
SEQRES 123 B 2163  SER ARG LYS ASP CYS MET GLU VAL ALA SER ALA PHE MET          
SEQRES 124 B 2163  LYS PHE SER LYS ALA ILE GLU TRP ASP MET LEU ASN VAL          
SEQRES 125 B 2163  GLU GLU GLU GLN ILE VAL PRO TYR ILE GLU LYS LEU THR          
SEQRES 126 B 2163  ASP GLY HIS LEU ARG ALA PRO LEU LYS HIS GLY VAL GLY          
SEQRES 127 B 2163  ILE LEU TYR LYS GLY MET ALA SER ASN ASP GLU ARG ILE          
SEQRES 128 B 2163  VAL LYS ARG LEU TYR GLU TYR GLY ALA VAL SER VAL LEU          
SEQRES 129 B 2163  LEU ILE SER LYS ASP CYS SER ALA PHE ALA CYS LYS THR          
SEQRES 130 B 2163  ASP GLU VAL ILE ILE LEU GLY THR ASN LEU TYR ASP GLY          
SEQRES 131 B 2163  ALA GLU HIS LYS TYR MET PRO TYR THR ILE ASN GLU LEU          
SEQRES 132 B 2163  LEU GLU MET VAL GLY LEU ALA SER GLY ASN ASP SER MET          
SEQRES 133 B 2163  ALA GLY LYS VAL LEU ILE LEU THR SER HIS ASN MET LYS          
SEQRES 134 B 2163  ALA TYR TYR LYS LYS PHE LEU ILE GLU PRO LEU PRO THR          
SEQRES 135 B 2163  GLU SER TYR LEU GLN TYR ILE ILE HIS ASP THR LEU ASN          
SEQRES 136 B 2163  ASN GLU ILE ALA ASN SER ILE ILE GLN SER LYS GLN ASP          
SEQRES 137 B 2163  CYS VAL ASP TRP PHE THR TYR SER TYR PHE TYR ARG ARG          
SEQRES 138 B 2163  ILE HIS VAL ASN PRO SER TYR TYR GLY VAL ARG ASP THR          
SEQRES 139 B 2163  SER PRO HIS GLY ILE SER VAL PHE LEU SER ASN LEU VAL          
SEQRES 140 B 2163  GLU THR CYS LEU ASN ASP LEU VAL GLU SER SER PHE ILE          
SEQRES 141 B 2163  GLU ILE ASP ASP THR GLU ALA GLU VAL THR ALA GLU VAL          
SEQRES 142 B 2163  ASN GLY GLY ASP ASP GLU ALA THR GLU ILE ILE SER THR          
SEQRES 143 B 2163  LEU SER ASN GLY LEU ILE ALA SER HIS TYR GLY VAL SER          
SEQRES 144 B 2163  PHE PHE THR ILE GLN SER PHE VAL SER SER LEU SER ASN          
SEQRES 145 B 2163  THR SER THR LEU LYS ASN MET LEU TYR VAL LEU SER THR          
SEQRES 146 B 2163  ALA VAL GLU PHE GLU SER VAL PRO LEU ARG LYS GLY ASP          
SEQRES 147 B 2163  ARG ALA LEU LEU VAL LYS LEU SER LYS ARG LEU PRO LEU          
SEQRES 148 B 2163  ARG PHE PRO GLU HIS THR SER SER GLY SER VAL SER PHE          
SEQRES 149 B 2163  LYS VAL PHE LEU LEU LEU GLN ALA TYR PHE SER ARG LEU          
SEQRES 150 B 2163  GLU LEU PRO VAL ASP PHE GLN ASN ASP LEU LYS ASP ILE          
SEQRES 151 B 2163  LEU GLU LYS VAL VAL PRO LEU ILE ASN VAL VAL VAL ASP          
SEQRES 152 B 2163  ILE LEU SER ALA ASN GLY TYR LEU ASN ALA THR THR ALA          
SEQRES 153 B 2163  MET ASP LEU ALA GLN MET LEU ILE GLN GLY VAL TRP ASP          
SEQRES 154 B 2163  VAL ASP ASN PRO LEU ARG GLN ILE PRO HIS PHE ASN ASN          
SEQRES 155 B 2163  LYS ILE LEU GLU LYS CYS LYS GLU ILE ASN VAL GLU THR          
SEQRES 156 B 2163  VAL TYR ASP ILE MET ALA LEU GLU ASP GLU GLU ARG ASP          
SEQRES 157 B 2163  GLU ILE LEU THR LEU THR ASP SER GLN LEU ALA GLN VAL          
SEQRES 158 B 2163  ALA ALA PHE VAL ASN ASN TYR PRO ASN VAL GLU LEU THR          
SEQRES 159 B 2163  TYR SER LEU ASN ASN SER ASP SER LEU ILE SER GLY VAL          
SEQRES 160 B 2163  LYS GLN LYS ILE THR ILE GLN LEU THR ARG ASP VAL GLU          
SEQRES 161 B 2163  PRO GLU ASN LEU GLN VAL THR SER GLU LYS TYR PRO PHE          
SEQRES 162 B 2163  ASP LYS LEU GLU SER TRP TRP LEU VAL LEU GLY GLU VAL          
SEQRES 163 B 2163  SER LYS LYS GLU LEU TYR ALA ILE LYS LYS VAL THR LEU          
SEQRES 164 B 2163  ASN LYS GLU THR GLN GLN TYR GLU LEU GLU PHE ASP THR          
SEQRES 165 B 2163  PRO THR SER GLY LYS HIS ASN LEU THR ILE TRP CYS VAL          
SEQRES 166 B 2163  CYS ASP SER TYR LEU ASP ALA ASP LYS GLU LEU SER PHE          
SEQRES 167 B 2163  GLU ILE ASN VAL LYS                                          
SEQRES   1 V   96    G   A   A   A   U   U   U   A   A   U   U   A   U          
SEQRES   2 V   96    A   A   A   C   C   A   G   A   C   C   G   U   C          
SEQRES   3 V   96    U   C   C   U   C   A   U   G   G   U   C   A   A          
SEQRES   4 V   96    U   U   C   G   G   U   G   U   U   C   G   C   U          
SEQRES   5 V   96    U   U   U   G   A   A   U   A   C   U   U   C   A          
SEQRES   6 V   96    A   G   A   C   U   A   U   G   U   A   G   G   G          
SEQRES   7 V   96    A   A   U   U   U   U   U   G   G   A   A   U   A          
SEQRES   8 V   96    C   C   U   U   U                                          
SEQRES   1 A  267  SER SER LYS ASN GLU TRP ARG LYS SER ALA ILE ALA ASN          
SEQRES   2 A  267  THR LEU LEU TYR LEU ARG LEU LYS ASN ILE TYR VAL SER          
SEQRES   3 A  267  ALA ASP ASP PHE VAL GLU GLU GLN ASN VAL TYR VAL LEU          
SEQRES   4 A  267  PRO LYS ASN LEU LEU LYS LYS PHE ILE GLU ILE SER ASP          
SEQRES   5 A  267  VAL LYS ILE GLN VAL ALA ALA PHE ILE TYR GLY MET SER          
SEQRES   6 A  267  ALA LYS ASP HIS PRO LYS VAL LYS GLU ILE LYS THR VAL          
SEQRES   7 A  267  VAL LEU VAL PRO GLN LEU GLY HIS VAL GLY SER VAL GLN          
SEQRES   8 A  267  ILE SER ASN ILE PRO ASP ILE GLY ASP LEU PRO ASP THR          
SEQRES   9 A  267  GLU GLY LEU GLU LEU LEU GLY TRP ILE HIS THR GLN THR          
SEQRES  10 A  267  GLU GLU LEU LYS PHE MET ALA ALA SER GLU VAL ALA THR          
SEQRES  11 A  267  HIS SER LYS LEU PHE ALA ASP LYS LYS ARG ASP CYS ILE          
SEQRES  12 A  267  ASP ILE SER ILE PHE SER THR PRO GLY SER VAL SER LEU          
SEQRES  13 A  267  SER ALA TYR ASN LEU THR ASP GLU GLY TYR GLN TRP GLY          
SEQRES  14 A  267  GLU GLU ASN LYS ASP ILE MET ASN VAL LEU SER GLU GLY          
SEQRES  15 A  267  PHE GLU PRO THR PHE SER THR HIS ALA GLN LEU LEU LEU          
SEQRES  16 A  267  SER ASP ARG ILE THR GLY ASN PHE ILE ILE PRO SER GLY          
SEQRES  17 A  267  ASN VAL TRP ASN TYR THR PHE MET GLY THR ALA PHE ASN          
SEQRES  18 A  267  GLN GLU GLY ASP TYR ASN PHE LYS TYR GLY ILE PRO LEU          
SEQRES  19 A  267  GLU PHE TYR ASN GLU MET HIS ARG PRO VAL HIS PHE LEU          
SEQRES  20 A  267  GLN PHE SER GLU LEU ALA GLY ASP GLU GLU LEU GLU ALA          
SEQRES  21 A  267  GLU GLN ILE ASP VAL PHE SER                                  
HELIX    1 AA1 LEU k   12  ILE k   16  5                                   5    
HELIX    2 AA2 LEU l    3  LEU l   10  1                                   8    
HELIX    3 AA3 LEU l  106  ASN l  114  1                                   9    
HELIX    4 AA4 ALA m   16  LEU m   21  1                                   6    
HELIX    5 AA5 GLU m   23  GLY m   29  1                                   7    
HELIX    6 AA6 MET m   31  THR m   40  1                                  10    
HELIX    7 AA7 GLY n    5  ALA n   14  1                                  10    
HELIX    8 AA8 PRO p   12  GLN p   24  1                                  13    
HELIX    9 AA9 ASN q   14  LEU q   22  1                                   9    
HELIX   10 AB1 ARG r   64  ILE r   68  5                                   5    
HELIX   11 AB2 ALA E    6  ALA E   25  1                                  20    
HELIX   12 AB3 ALA E   41  ALA E   53  1                                  13    
HELIX   13 AB4 ALA E  122  ALA E  126  5                                   5    
HELIX   14 AB5 ALA E  158  ALA E  164  1                                   7    
HELIX   15 AB6 ALA E  185  ALA E  190  5                                   6    
HELIX   16 AB7 ALA E  214  ALA E  220  5                                   7    
HELIX   17 AB8 ALA E  243  ALA E  248  1                                   6    
HELIX   18 AB9 ALA E  273  ALA E  277  5                                   5    
HELIX   19 AC1 ALA E  311  ALA E  315  1                                   5    
HELIX   20 AC2 ALA E  357  ALA E  362  1                                   6    
HELIX   21 AC3 ALA E  365  ALA E  388  1                                  24    
HELIX   22 AC4 ALA E  396  ALA E  407  1                                  12    
HELIX   23 AC5 ALA E  495  ALA E  500  1                                   6    
HELIX   24 AC6 ALA E  502  ALA E  510  1                                   9    
HELIX   25 AC7 THR E  541  ASN E  558  1                                  18    
HELIX   26 AC8 ASP B  485  ALA B  490  5                                   6    
HELIX   27 AC9 ILE B  502  GLY B  513  1                                  12    
HELIX   28 AD1 GLY B  526  HIS B  541  1                                  16    
HELIX   29 AD2 LEU B  563  LEU B  578  1                                  16    
HELIX   30 AD3 LYS B  597  THR B  602  1                                   6    
HELIX   31 AD4 THR B  608  ASN B  618  1                                  11    
HELIX   32 AD5 ASN B  621  LEU B  627  1                                   7    
HELIX   33 AD6 GLU B  635  ASP B  641  5                                   7    
HELIX   34 AD7 GLY B  644  ALA B  657  1                                  14    
HELIX   35 AD8 ASN B  676  LEU B  684  1                                   9    
HELIX   36 AD9 ASP B  695  ARG B  699  5                                   5    
HELIX   37 AE1 ASN B  714  ASN B  735  1                                  22    
HELIX   38 AE2 SER B  746  ASN B  765  1                                  20    
HELIX   39 AE3 ILE B  766  THR B  771  1                                   6    
HELIX   40 AE4 GLY B  776  ALA B  786  1                                  11    
HELIX   41 AE5 LEU B  793  GLY B  800  1                                   8    
HELIX   42 AE6 THR B  809  ASP B  822  1                                  14    
HELIX   43 AE7 ALA B  832  GLY B  837  1                                   6    
HELIX   44 AE8 SER B  864  GLY B  873  1                                  10    
HELIX   45 AE9 ASP B  891  ASN B  903  1                                  13    
HELIX   46 AF1 GLN B  911  GLY B  927  1                                  17    
HELIX   47 AF2 CYS B  931  TYR B  941  1                                  11    
HELIX   48 AF3 THR B  942  SER B  951  1                                  10    
HELIX   49 AF4 PRO B  952  LYS B  956  5                                   5    
HELIX   50 AF5 ASP B  959  GLY B  964  1                                   6    
HELIX   51 AF6 LYS B  968  GLN B  984  1                                  17    
HELIX   52 AF7 THR B  999  PHE B 1008  1                                  10    
HELIX   53 AF8 ASN B 1011  LEU B 1022  1                                  12    
HELIX   54 AF9 THR B 1027  SER B 1038  1                                  12    
HELIX   55 AG1 ARG B 1047  ALA B 1061  1                                  15    
HELIX   56 AG2 ASP B 1071  GLN B 1086  1                                  16    
HELIX   57 AG3 GLY B 1091  GLY B 1120  1                                  30    
HELIX   58 AG4 TRP B 1121  LYS B 1138  1                                  18    
HELIX   59 AG5 CYS B 1144  PHE B 1149  5                                   6    
HELIX   60 AG6 PRO B 1153  SER B 1163  1                                  11    
HELIX   61 AG7 PRO B 1166  LEU B 1173  1                                   8    
HELIX   62 AG8 THR B 1175  ALA B 1182  1                                   8    
HELIX   63 AG9 TYR B 1188  LEU B 1195  1                                   8    
HELIX   64 AH1 LYS B 1277  ASN B 1283  1                                   7    
HELIX   65 AH2 ASP B 1338  PHE B 1343  5                                   6    
HELIX   66 AH3 ASN B 1349  TYR B 1360  1                                  12    
HELIX   67 AH4 GLY B 1375  GLN B 1390  1                                  16    
HELIX   68 AH5 SER B 1401  GLY B 1421  1                                  21    
HELIX   69 AH6 ASP B 1431  SER B 1442  1                                  12    
HELIX   70 AH7 THR B 1448  ARG B 1457  1                                  10    
HELIX   71 AH8 ARG B 1462  SER B 1467  1                                   6    
HELIX   72 AH9 VAL B 1483  THR B 1500  1                                  18    
HELIX   73 AI1 ALA B 1518  ALA B 1525  1                                   8    
HELIX   74 AI2 THR B 1528  ILE B 1532  5                                   5    
HELIX   75 AI3 SER B 1536  ARG B 1540  5                                   5    
HELIX   76 AI4 ASN B 1560  ASN B 1577  1                                  18    
HELIX   77 AI5 SER B 1587  ILE B 1605  1                                  19    
HELIX   78 AI6 GLU B 1613  ILE B 1621  1                                   9    
HELIX   79 AI7 ASP B 1626  LYS B 1634  1                                   9    
HELIX   80 AI8 ALA B 1645  TYR B 1658  1                                  14    
HELIX   81 AI9 ASP B 1669  PHE B 1673  5                                   5    
HELIX   82 AJ1 THR B 1699  LEU B 1709  1                                  11    
HELIX   83 AJ2 HIS B 1726  LEU B 1736  1                                  11    
HELIX   84 AJ3 TYR B 1745  ASN B 1760  1                                  16    
HELIX   85 AJ4 GLN B 1767  TYR B 1775  1                                   9    
HELIX   86 AJ5 SER B 1776  HIS B 1783  1                                   8    
HELIX   87 AJ6 HIS B 1797  VAL B 1815  1                                  19    
HELIX   88 AJ7 LEU B 1847  GLY B 1857  1                                  11    
HELIX   89 AJ8 SER B 1859  LEU B 1870  1                                  12    
HELIX   90 AJ9 THR B 1875  THR B 1885  1                                  11    
HELIX   91 AK1 ALA B 1886  SER B 1891  5                                   6    
HELIX   92 AK2 GLY B 1897  LYS B 1907  1                                  11    
HELIX   93 AK3 SER B 1921  SER B 1935  1                                  15    
HELIX   94 AK4 PRO B 1940  GLY B 1969  1                                  30    
HELIX   95 AK5 ASN B 1972  GLY B 1986  1                                  15    
HELIX   96 AK6 ASN B 2001  GLU B 2010  1                                  10    
HELIX   97 AK7 VAL B 2016  LEU B 2022  1                                   7    
HELIX   98 AK8 GLU B 2023  LEU B 2031  1                                   9    
HELIX   99 AK9 THR B 2034  TYR B 2048  1                                  15    
HELIX  100 AL1 SER A 2148  THR A 2160  1                                  13    
HELIX  101 AL2 LEU A 2161  LYS A 2167  5                                   7    
HELIX  102 AL3 LYS A 2187  SER A 2197  1                                  11    
HELIX  103 AL4 ALA A 2270  PHE A 2281  1                                  12    
HELIX  104 AL5 THR A 2308  LYS A 2319  1                                  12    
HELIX  105 AL6 MET A 2322  GLU A 2330  1                                   9    
HELIX  106 AL7 ARG A 2388  GLU A 2397  1                                  10    
SHEET    1 AA1 6 VAL k  44  LEU k  45  0                                        
SHEET    2 AA1 6 TYR k  30  ALA k  36 -1  N  MET k  35   O  VAL k  44           
SHEET    3 AA1 6 LYS k  19  THR k  24 -1  N  VAL k  22   O  TYR k  30           
SHEET    4 AA1 6 ILE k  92  VAL k  97 -1  O  VAL k  96   N  ARG k  21           
SHEET    5 AA1 6 ILE l  85  ILE l  87 -1  O  ASN l  86   N  THR k  95           
SHEET    6 AA1 6 ILE l  39  LEU l  40 -1  N  LEU l  40   O  ILE l  85           
SHEET    1 AA2 6 LEU k  84  LEU k  87  0                                        
SHEET    2 AA2 6 ILE n  69  VAL n  74 -1  O  ILE n  72   N  ILE k  86           
SHEET    3 AA2 6 ILE n  18  LEU n  23 -1  N  SER n  20   O  VAL n  73           
SHEET    4 AA2 6 THR n  28  LYS n  32 -1  O  GLY n  31   N  VAL n  19           
SHEET    5 AA2 6 ILE n  48  THR n  50 -1  O  THR n  50   N  THR n  28           
SHEET    6 AA2 6 THR n  57  HIS n  58 -1  O  THR n  57   N  ALA n  49           
SHEET    1 AA3 2 GLN l  14  THR l  16  0                                        
SHEET    2 AA3 2 TRP l  26  THR l  28 -1  O  GLY l  27   N  VAL l  15           
SHEET    1 AA4 2 GLU l  18  LEU l  19  0                                        
SHEET    2 AA4 2 ILE l  92  GLN l  94 -1  O  GLN l  94   N  GLU l  18           
SHEET    1 AA5 4 PRO m  43  SER m  47  0                                        
SHEET    2 AA5 4 LYS m  53  ALA m  60 -1  O  ILE m  54   N  ILE m  46           
SHEET    3 AA5 4 VAL m  68  THR m  77 -1  O  LYS m  73   N  ILE m  55           
SHEET    4 AA5 4 ASN m  86  ILE m  91 -1  O  ILE m  91   N  VAL m  72           
SHEET    1 AA6 6 VAL m 103  LEU m 105  0                                        
SHEET    2 AA6 6 VAL q  63  ILE q  73 -1  O  PHE q  72   N  VAL m 104           
SHEET    3 AA6 6 LEU q  51  VAL q  60 -1  N  VAL q  60   O  VAL q  63           
SHEET    4 AA6 6 GLU q  37  LEU q  42 -1  N  GLU q  37   O  PHE q  59           
SHEET    5 AA6 6 ARG q  26  LEU q  31 -1  N  VAL q  27   O  GLY q  40           
SHEET    6 AA6 6 VAL q  78  ARG q  82 -1  O  LEU q  79   N  LYS q  30           
SHEET    1 AA7 7 VAL n  42  ARG n  45  0                                        
SHEET    2 AA7 7 GLN n  61  VAL n  64 -1  O  VAL n  64   N  VAL n  42           
SHEET    3 AA7 7 SER r  70  ALA r  73 -1  O  LEU r  71   N  PHE n  63           
SHEET    4 AA7 7 LYS r  14  ASN r  18 -1  N  LEU r  16   O  GLU r  72           
SHEET    5 AA7 7 ALA r  26  GLY r  31 -1  O  GLY r  27   N  ILE r  15           
SHEET    6 AA7 7 VAL r  39  LEU r  40 -1  O  VAL r  39   N  GLY r  31           
SHEET    7 AA7 7 THR r  61  VAL r  62 -1  O  THR r  61   N  LEU r  40           
SHEET    1 AA8 3 ILE p  37  ILE p  43  0                                        
SHEET    2 AA8 3 VAL p  52  PRO p  61 -1  O  ILE p  60   N  ARG p  38           
SHEET    3 AA8 3 ILE p  80  LEU p  82 -1  O  ILE p  80   N  ILE p  54           
SHEET    1 AA9 2 MET r  44  GLU r  45  0                                        
SHEET    2 AA9 2 HIS r  55  GLN r  56 -1  O  HIS r  55   N  GLU r  45           
SHEET    1 AB1 2 ILE B 463  HIS B 464  0                                        
SHEET    2 AB1 2 GLN B 706  PHE B 707 -1  O  PHE B 707   N  ILE B 463           
SHEET    1 AB2 7 VAL B 585  GLU B 587  0                                        
SHEET    2 AB2 7 VAL B 604  SER B 607  1  O  VAL B 604   N  ALA B 586           
SHEET    3 AB2 7 LYS B 556  ILE B 560  1  N  TYR B 559   O  SER B 607           
SHEET    4 AB2 7 VAL B 628  ILE B 633  1  O  ILE B 632   N  ILE B 560           
SHEET    5 AB2 7 ARG B 666  SER B 671  1  O  ILE B 668   N  ILE B 633           
SHEET    6 AB2 7 MET B 517  CYS B 520  1  N  MET B 517   O  GLY B 669           
SHEET    7 AB2 7 LEU B 691  TYR B 693  1  O  PHE B 692   N  LEU B 518           
SHEET    1 AB3 6 LEU B 703  SER B 704  0                                        
SHEET    2 AB3 6 GLY B 884  GLY B 886  1  O  GLY B 884   N  SER B 704           
SHEET    3 AB3 6 THR B 844  ILE B 847  1  N  VAL B 845   O  GLU B 885           
SHEET    4 AB3 6 ILE B 740  PHE B 743  1  N  ILE B 741   O  THR B 844           
SHEET    5 AB3 6 VAL B 827  CYS B 830  1  O  LEU B 828   N  ILE B 740           
SHEET    6 AB3 6 THR B 803  HIS B 804  1  N  HIS B 804   O  VAL B 829           
SHEET    1 AB4 2 TYR B 853  SER B 854  0                                        
SHEET    2 AB4 2 SER B 859  TRP B 860 -1  N  SER B 859   O  SER B 854           
SHEET    1 AB5 2 VAL B 987  LEU B 988  0                                        
SHEET    2 AB5 2 GLU B 997  ALA B 998 -1  O  GLU B 997   N  LEU B 988           
SHEET    1 AB6 3 THR B1205  GLN B1209  0                                        
SHEET    2 AB6 3 MET B1216  ILE B1222 -1  O  GLU B1221   N  THR B1205           
SHEET    3 AB6 3 PHE B1268  TYR B1274 -1  O  LEU B1270   N  ILE B1220           
SHEET    1 AB7 4 ILE B1251  ILE B1259  0                                        
SHEET    2 AB7 4 GLU B1237  GLU B1244 -1  N  LEU B1243   O  LEU B1252           
SHEET    3 AB7 4 ASN B1287  LEU B1292 -1  O  THR B1291   N  MET B1242           
SHEET    4 AB7 4 PHE B1302  SER B1307 -1  O  ILE B1304   N  LEU B1290           
SHEET    1 AB8 6 VAL B1366  GLY B1369  0                                        
SHEET    2 AB8 6 ARG B1507  LEU B1511  1  O  CYS B1510   N  VAL B1366           
SHEET    3 AB8 6 LEU B1470  TYR B1473  1  N  MET B1471   O  VAL B1509           
SHEET    4 AB8 6 ALA B1395  ILE B1398  1  N  ILE B1398   O  ILE B1472           
SHEET    5 AB8 6 VAL B1444  LEU B1446  1  O  LEU B1445   N  ALA B1395           
SHEET    6 AB8 6 ILE B1425  LYS B1427  1  N  ASN B1426   O  LEU B1446           
SHEET    1 AB9 6 LEU B1544  PHE B1551  0                                        
SHEET    2 AB9 6 GLY B1718  SER B1725  1  O  VAL B1720   N  ASN B1547           
SHEET    3 AB9 6 GLU B1679  LEU B1683  1  N  ILE B1682   O  LEU B1723           
SHEET    4 AB9 6 SER B1581  LEU B1585  1  N  SER B1582   O  ILE B1681           
SHEET    5 AB9 6 LEU B1664  SER B1667  1  O  LEU B1664   N  VAL B1583           
SHEET    6 AB9 6 GLY B1638  LEU B1640  1  N  GLY B1638   O  LEU B1665           
SHEET    1 AC1 2 TYR B1688  ASP B1689  0                                        
SHEET    2 AC1 2 LYS B1694  TYR B1695 -1  O  LYS B1694   N  ASP B1689           
SHEET    1 AC2 2 ILE B1820  ASP B1823  0                                        
SHEET    2 AC2 2 ILE B1843  THR B1846 -1  O  SER B1845   N  GLU B1821           
SHEET    1 AC3 3 GLU B2052  LEU B2057  0                                        
SHEET    2 AC3 3 ILE B2071  THR B2076 -1  O  THR B2072   N  SER B2056           
SHEET    3 AC3 3 THR B2123  GLU B2127 -1  O  TYR B2126   N  ILE B2073           
SHEET    1 AC4 2 LYS B2068  GLN B2069  0                                        
SHEET    2 AC4 2 PHE B2130  ASP B2131 -1  N  PHE B2130   O  GLN B2069           
SHEET    1 AC5 2 GLN B2085  VAL B2086  0                                        
SHEET    2 AC5 2 LYS B2095  LEU B2096 -1  O  LYS B2095   N  VAL B2086           
SHEET    1 AC6 4 GLU B2110  VAL B2117  0                                        
SHEET    2 AC6 4 TRP B2099  GLU B2105 -1  N  LEU B2101   O  LYS B2115           
SHEET    3 AC6 4 GLY B2136  CYS B2146 -1  O  THR B2141   N  GLY B2104           
SHEET    4 AC6 4 LEU B2156  VAL B2162 -1  O  VAL B2162   N  GLY B2136           
SHEET    1 AC7 4 ASN A2168  ILE A2169  0                                        
SHEET    2 AC7 4 SER A2299  TYR A2305  1  O  VAL A2300   N  ASN A2168           
SHEET    3 AC7 4 ASP A2290  THR A2296 -1  N  ASP A2290   O  TYR A2305           
SHEET    4 AC7 4 HIS A2260  GLN A2262  1  N  HIS A2260   O  ILE A2291           
SHEET    1 AC8 5 GLU A2254  TRP A2258  0                                        
SHEET    2 AC8 5 PHE A2206  MET A2210 -1  N  ILE A2207   O  GLY A2257           
SHEET    3 AC8 5 LYS A2219  VAL A2225 -1  O  THR A2223   N  TYR A2208           
SHEET    4 AC8 5 VAL A2182  PRO A2186  1  N  VAL A2184   O  LYS A2219           
SHEET    5 AC8 5 GLN A2338  SER A2342  1  O  LEU A2340   N  TYR A2183           
SHEET    1 AC9 5 GLU A2254  TRP A2258  0                                        
SHEET    2 AC9 5 PHE A2206  MET A2210 -1  N  ILE A2207   O  GLY A2257           
SHEET    3 AC9 5 LYS A2219  VAL A2225 -1  O  THR A2223   N  TYR A2208           
SHEET    4 AC9 5 ASN A2348  PRO A2352  1  O  ASN A2348   N  VAL A2224           
SHEET    5 AC9 5 PHE A2374  TYR A2376 -1  O  LYS A2375   N  ILE A2351           
SHEET    1 AD1 2 GLN A2229  HIS A2232  0                                        
SHEET    2 AD1 2 SER A2235  ILE A2238 -1  O  SER A2235   N  HIS A2232           
CISPEP   1 ALA n   81    PRO n   82          0         0.00                     
CISPEP   2 LEU B  448    PRO B  449          0        -1.87                     
CISPEP   3 SER B 1370    GLY B 1371          0         5.41                     
CISPEP   4 THR B 1625    ASP B 1626          0         2.57                     
CISPEP   5 THR A 2332    PHE A 2333          0        15.71                     
CRYST1  543.400  543.400  543.400  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.001840  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.001840  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.001840        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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