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Database: PDB
Entry: 5HQ2
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Original site: 5HQ2 
HEADER    TRANSFERASE/DNA                         21-JAN-16   5HQ2              
TITLE     STRUCTURAL MODEL OF SET8 HISTONE H4 LYS20 METHYLTRANSFERASE BOUND TO  
TITLE    2 NUCLEOSOME CORE PARTICLE                                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: HISTONE H3.2;                                              
COMPND   3 CHAIN: A;                                                            
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: HISTONE H4;                                                
COMPND   7 CHAIN: B;                                                            
COMPND   8 ENGINEERED: YES;                                                     
COMPND   9 MOL_ID: 3;                                                           
COMPND  10 MOLECULE: HISTONE H2A;                                               
COMPND  11 CHAIN: G;                                                            
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 4;                                                           
COMPND  14 MOLECULE: HISTONE H2B 1.1;                                           
COMPND  15 CHAIN: H;                                                            
COMPND  16 SYNONYM: H2B1.1;                                                     
COMPND  17 ENGINEERED: YES;                                                     
COMPND  18 MOL_ID: 5;                                                           
COMPND  19 MOLECULE: DNA (149-MER);                                             
COMPND  20 CHAIN: I;                                                            
COMPND  21 ENGINEERED: YES;                                                     
COMPND  22 MOL_ID: 6;                                                           
COMPND  23 MOLECULE: DNA (149-MER);                                             
COMPND  24 CHAIN: J;                                                            
COMPND  25 ENGINEERED: YES;                                                     
COMPND  26 MOL_ID: 7;                                                           
COMPND  27 MOLECULE: GUANINE NUCLEOTIDE EXCHANGE FACTOR SRM1;                   
COMPND  28 CHAIN: K;                                                            
COMPND  29 SYNONYM: PHEROMONE RESPONSE PATHWAY COMPONENT SRM1,PRE-MRNA-         
COMPND  30 PROCESSING PROTEIN 20,REGULATOR OF CHROMOSOME CONDENSATION,SUPPRESSOR
COMPND  31 OF RECEPTOR MUTATIONS 1,MRNA TRANSPORT PROTEIN 1;                    
COMPND  32 ENGINEERED: YES;                                                     
COMPND  33 MOL_ID: 8;                                                           
COMPND  34 MOLECULE: N-LYSINE METHYLTRANSFERASE SETD8;                          
COMPND  35 CHAIN: M;                                                            
COMPND  36 SYNONYM: H4-K20-HMTASE SETD8,HISTONE-LYSINE N-METHYLTRANSFERASE      
COMPND  37 SETD8,LYSINE N-METHYLTRANSFERASE 5A,PR/SET DOMAIN-CONTAINING PROTEIN 
COMPND  38 07,PR/SET07,SET DOMAIN-CONTAINING PROTEIN 8;                         
COMPND  39 EC: 2.1.1.-,2.1.1.43;                                                
COMPND  40 ENGINEERED: YES;                                                     
COMPND  41 MUTATION: YES                                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: XENOPUS LAEVIS;                                 
SOURCE   3 ORGANISM_COMMON: AFRICAN CLAWED FROG;                                
SOURCE   4 ORGANISM_TAXID: 8355;                                                
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3)PLYSS;                            
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: PET3D;                                    
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: XENOPUS LAEVIS;                                 
SOURCE  11 ORGANISM_COMMON: AFRICAN CLAWED FROG;                                
SOURCE  12 ORGANISM_TAXID: 8355;                                                
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  15 EXPRESSION_SYSTEM_STRAIN: BL21(DE3)PLYSS;                            
SOURCE  16 EXPRESSION_SYSTEM_PLASMID: PET3A;                                    
SOURCE  17 MOL_ID: 3;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: XENOPUS LAEVIS;                                 
SOURCE  19 ORGANISM_COMMON: AFRICAN CLAWED FROG;                                
SOURCE  20 ORGANISM_TAXID: 8355;                                                
SOURCE  21 GENE: HIST1H2AJ, LOC494591;                                          
SOURCE  22 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  23 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  24 EXPRESSION_SYSTEM_STRAIN: BL21(DE3)PLYSS;                            
SOURCE  25 EXPRESSION_SYSTEM_PLASMID: PET3A;                                    
SOURCE  26 MOL_ID: 4;                                                           
SOURCE  27 ORGANISM_SCIENTIFIC: XENOPUS LAEVIS;                                 
SOURCE  28 ORGANISM_COMMON: AFRICAN CLAWED FROG;                                
SOURCE  29 ORGANISM_TAXID: 8355;                                                
SOURCE  30 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  31 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  32 EXPRESSION_SYSTEM_STRAIN: BL21(DE3)PLYSS;                            
SOURCE  33 EXPRESSION_SYSTEM_PLASMID: PET3A;                                    
SOURCE  34 MOL_ID: 5;                                                           
SOURCE  35 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE  36 ORGANISM_TAXID: 32630;                                               
SOURCE  37 GENE: WIDOM 601 NUCLEOSOME POSITIONING SEQUENCE;                     
SOURCE  38 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  39 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  40 EXPRESSION_SYSTEM_STRAIN: HB101;                                     
SOURCE  41 EXPRESSION_SYSTEM_PLASMID: PLASMID;                                  
SOURCE  42 MOL_ID: 6;                                                           
SOURCE  43 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE  44 ORGANISM_TAXID: 32630;                                               
SOURCE  45 GENE: WIDOM 601 NUCLEOSOME POSITIONING SEQUENCE;                     
SOURCE  46 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  47 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  48 EXPRESSION_SYSTEM_STRAIN: HB101;                                     
SOURCE  49 EXPRESSION_SYSTEM_PLASMID: PLASMID;                                  
SOURCE  50 MOL_ID: 7;                                                           
SOURCE  51 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  52 S288C);                                                              
SOURCE  53 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  54 ORGANISM_TAXID: 559292;                                              
SOURCE  55 STRAIN: ATCC 204508 / S288C;                                         
SOURCE  56 GENE: SRM1, MTR1, PRP20, YGL097W;                                    
SOURCE  57 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  58 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  59 EXPRESSION_SYSTEM_STRAIN: BL21(DE3)PLYSS;                            
SOURCE  60 EXPRESSION_SYSTEM_PLASMID: PST50TR;                                  
SOURCE  61 MOL_ID: 8;                                                           
SOURCE  62 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  63 ORGANISM_COMMON: HUMAN;                                              
SOURCE  64 ORGANISM_TAXID: 9606;                                                
SOURCE  65 GENE: SETD8, KMT5A, PRSET7, SET07, SET8;                             
SOURCE  66 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  67 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  68 EXPRESSION_SYSTEM_STRAIN: BL21(DE3)PLYSS;                            
SOURCE  69 EXPRESSION_SYSTEM_PLASMID: PST50TR                                   
KEYWDS    CHROMATIN ENZYME, CHROMATIN COMPLEX, EPIGENETICS, HISTONE             
KEYWDS   2 METHYLTRANSFERASE, TRANSFERASE-DNA COMPLEX                           
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    G.TAVAREKERE,R.K.MCGINTY,S.TAN                                        
REVDAT   5   01-NOV-17 5HQ2    1       REMARK                                   
REVDAT   4   27-SEP-17 5HQ2    1       REMARK                                   
REVDAT   3   06-SEP-17 5HQ2    1       JRNL   REMARK                            
REVDAT   2   27-APR-16 5HQ2    1       JRNL                                     
REVDAT   1   23-MAR-16 5HQ2    0                                                
JRNL        AUTH   T.S.GIRISH,R.K.MCGINTY,S.TAN                                 
JRNL        TITL   MULTIVALENT INTERACTIONS BY THE SET8 HISTONE                 
JRNL        TITL 2 METHYLTRANSFERASE WITH ITS NUCLEOSOME SUBSTRATE.             
JRNL        REF    J.MOL.BIOL.                   V. 428  1531 2016              
JRNL        REFN                   ESSN 1089-8638                               
JRNL        PMID   26953260                                                     
JRNL        DOI    10.1016/J.JMB.2016.02.025                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.50 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.8.0103                                      
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON                               
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 4.50                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 46.00                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.3                           
REMARK   3   NUMBER OF REFLECTIONS             : 15908                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.342                           
REMARK   3   R VALUE            (WORKING SET) : 0.339                           
REMARK   3   FREE R VALUE                     : 0.397                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 845                             
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 4.50                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 4.62                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 1125                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 96.48                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3600                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 55                           
REMARK   3   BIN FREE R VALUE                    : 0.4390                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 4767                                    
REMARK   3   NUCLEIC ACID ATOMS       : 2971                                    
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 0                                       
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 171.9                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 11.93000                                             
REMARK   3    B22 (A**2) : -7.31000                                             
REMARK   3    B33 (A**2) : -4.62000                                             
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): NULL          
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 1.271         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 1.580         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 124.392       
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.864                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.832                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  8112 ; 0.007 ; 0.016       
REMARK   3   BOND LENGTHS OTHERS               (A):  4618 ; 0.004 ; 0.020       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 11783 ; 0.990 ; 1.616       
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 10286 ; 1.359 ; 3.000       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   950 ; 6.318 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1316 ; 0.052 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  8379 ; 0.004 ; 0.020       
REMARK   3   GENERAL PLANES OTHERS             (A):  1646 ; 0.002 ; 0.020       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  3827 ; 9.967 ;21.797       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  3826 ; 9.951 ;21.796       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  4768 ;17.743 ;32.658       
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  4769 ;17.743 ;32.660       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  4285 ;10.886 ;22.729       
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  4286 ;10.885 ;22.731       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  7015 ;16.727 ;34.012       
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  9255 ;27.075 ;  NULL       
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  9256 ;27.076 ;  NULL       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL                              
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : MASK                                                 
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING   
REMARK   3  POSITIONS                                                           
REMARK   4                                                                      
REMARK   4 5HQ2 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-JAN-16.                  
REMARK 100 THE DEPOSITION ID IS D_1000217020.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 30-JUL-13                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 5.5-6                              
REMARK 200  NUMBER OF CRYSTALS USED        : NULL                               
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 24-ID-E                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9792                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315                   
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : SCALA                              
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 16854                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 4.500                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 46.190                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8                               
REMARK 200  DATA REDUNDANCY                : 7.300                              
REMARK 200  R MERGE                    (I) : 0.09500                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 12.9000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 4.50                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 4.74                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.8                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 7.40                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.85200                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.400                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 60.37                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.10                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 25 MM SODIUM ACETATE PH 5.5, 40 MM       
REMARK 280  SODIUM CITRATE,1 MM DTT, 6% PEG2000-MME, MICROBATCH, TEMPERATURE    
REMARK 280  277K                                                                
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 2 2 21                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,-Y,Z+1/2                                             
REMARK 290       3555   -X,Y,-Z+1/2                                             
REMARK 290       4555   X,-Y,-Z                                                 
REMARK 290       5555   X+1/2,Y+1/2,Z                                           
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2                                     
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2                                     
REMARK 290       8555   X+1/2,-Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       91.04500            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       91.04500            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       50.36450            
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000      150.37600            
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       50.36450            
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000      150.37600            
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       91.04500            
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       50.36450            
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000      150.37600            
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       91.04500            
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       50.36450            
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000      150.37600            
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 300 REMARK: GEL FILTRATION USED TO CONFIRM ASSEMBLY                      
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXADECAMERIC                     
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, G, H, I, J, K, M                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, G, H, I, J, K, M                
REMARK 350   BIOMT1   2  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ALA A     1                                                      
REMARK 465     ARG A     2                                                      
REMARK 465     THR A     3                                                      
REMARK 465     LYS A     4                                                      
REMARK 465     GLN A     5                                                      
REMARK 465     THR A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     LYS A     9                                                      
REMARK 465     SER A    10                                                      
REMARK 465     THR A    11                                                      
REMARK 465     GLY A    12                                                      
REMARK 465     GLY A    13                                                      
REMARK 465     LYS A    14                                                      
REMARK 465     ALA A    15                                                      
REMARK 465     PRO A    16                                                      
REMARK 465     ARG A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     GLN A    19                                                      
REMARK 465     LEU A    20                                                      
REMARK 465     ALA A    21                                                      
REMARK 465     THR A    22                                                      
REMARK 465     LYS A    23                                                      
REMARK 465     ALA A    24                                                      
REMARK 465     ALA A    25                                                      
REMARK 465     ARG A    26                                                      
REMARK 465     LYS A    27                                                      
REMARK 465     SER A    28                                                      
REMARK 465     ALA A    29                                                      
REMARK 465     PRO A    30                                                      
REMARK 465     ALA A    31                                                      
REMARK 465     THR A    32                                                      
REMARK 465     GLY A    33                                                      
REMARK 465     GLY A    34                                                      
REMARK 465     VAL A    35                                                      
REMARK 465     LYS A    36                                                      
REMARK 465     SER B     1                                                      
REMARK 465     GLY B     2                                                      
REMARK 465     ARG B     3                                                      
REMARK 465     GLY B     4                                                      
REMARK 465     LYS B     5                                                      
REMARK 465     GLY B     6                                                      
REMARK 465     GLY B     7                                                      
REMARK 465     LYS B     8                                                      
REMARK 465     GLY B     9                                                      
REMARK 465     LEU B    10                                                      
REMARK 465     GLY B    11                                                      
REMARK 465     LYS B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     GLY B    14                                                      
REMARK 465     ALA B    15                                                      
REMARK 465     LYS B    16                                                      
REMARK 465     ARG B    17                                                      
REMARK 465     HIS B    18                                                      
REMARK 465     ARG B    19                                                      
REMARK 465     LYS B    20                                                      
REMARK 465     VAL B    21                                                      
REMARK 465     LEU B    22                                                      
REMARK 465     ARG B    23                                                      
REMARK 465     GLY B   102                                                      
REMARK 465     SER G     1                                                      
REMARK 465     GLY G     2                                                      
REMARK 465     ARG G     3                                                      
REMARK 465     GLY G     4                                                      
REMARK 465     LYS G     5                                                      
REMARK 465     GLN G     6                                                      
REMARK 465     GLY G     7                                                      
REMARK 465     GLY G     8                                                      
REMARK 465     LYS G     9                                                      
REMARK 465     THR G    10                                                      
REMARK 465     ARG G    11                                                      
REMARK 465     ALA G    12                                                      
REMARK 465     LYS G    13                                                      
REMARK 465     ALA G    14                                                      
REMARK 465     THR G   120                                                      
REMARK 465     GLU G   121                                                      
REMARK 465     SER G   122                                                      
REMARK 465     SER G   123                                                      
REMARK 465     LYS G   124                                                      
REMARK 465     SER G   125                                                      
REMARK 465     ALA G   126                                                      
REMARK 465     LYS G   127                                                      
REMARK 465     SER G   128                                                      
REMARK 465     LYS G   129                                                      
REMARK 465     ALA H     1                                                      
REMARK 465     LYS H     2                                                      
REMARK 465     SER H     3                                                      
REMARK 465     ALA H     4                                                      
REMARK 465     PRO H     5                                                      
REMARK 465     ALA H     6                                                      
REMARK 465     PRO H     7                                                      
REMARK 465     LYS H     8                                                      
REMARK 465     LYS H     9                                                      
REMARK 465     GLY H    10                                                      
REMARK 465     SER H    11                                                      
REMARK 465     LYS H    12                                                      
REMARK 465     LYS H    13                                                      
REMARK 465     ALA H    14                                                      
REMARK 465     VAL H    15                                                      
REMARK 465     THR H    16                                                      
REMARK 465     LYS H    17                                                      
REMARK 465     THR H    18                                                      
REMARK 465     GLN H    19                                                      
REMARK 465     LYS H    20                                                      
REMARK 465     LYS H    21                                                      
REMARK 465     ASP H    22                                                      
REMARK 465     GLY H    23                                                      
REMARK 465     LYS H    24                                                      
REMARK 465     LYS H    25                                                      
REMARK 465     ARG H    26                                                      
REMARK 465     ARG H    27                                                      
REMARK 465      DA I   -74                                                      
REMARK 465      DT I   -73                                                      
REMARK 465      DC I   -72                                                      
REMARK 465      DG I   -71                                                      
REMARK 465      DG I   -70                                                      
REMARK 465      DA I   -69                                                      
REMARK 465      DG I   -68                                                      
REMARK 465      DA I   -67                                                      
REMARK 465      DA I   -66                                                      
REMARK 465      DT I   -65                                                      
REMARK 465      DC I   -64                                                      
REMARK 465      DC I   -63                                                      
REMARK 465      DC I   -62                                                      
REMARK 465      DG I   -61                                                      
REMARK 465      DG I   -60                                                      
REMARK 465      DT I   -59                                                      
REMARK 465      DG I   -58                                                      
REMARK 465      DC I   -57                                                      
REMARK 465      DC I   -56                                                      
REMARK 465      DG I   -55                                                      
REMARK 465      DA I   -54                                                      
REMARK 465      DG I   -53                                                      
REMARK 465      DG I   -52                                                      
REMARK 465      DC I   -51                                                      
REMARK 465      DC I   -50                                                      
REMARK 465      DG I   -49                                                      
REMARK 465      DC I   -48                                                      
REMARK 465      DT I   -47                                                      
REMARK 465      DC I   -46                                                      
REMARK 465      DA I   -45                                                      
REMARK 465      DA I   -44                                                      
REMARK 465      DT I   -43                                                      
REMARK 465      DT I   -42                                                      
REMARK 465      DG I   -41                                                      
REMARK 465      DG I   -40                                                      
REMARK 465      DT I     1                                                      
REMARK 465      DG I     2                                                      
REMARK 465      DT I     3                                                      
REMARK 465      DC I     4                                                      
REMARK 465      DC I     5                                                      
REMARK 465      DC I     6                                                      
REMARK 465      DC I     7                                                      
REMARK 465      DC I     8                                                      
REMARK 465      DG I     9                                                      
REMARK 465      DC I    10                                                      
REMARK 465      DG I    11                                                      
REMARK 465      DT I    12                                                      
REMARK 465      DT I    13                                                      
REMARK 465      DT I    14                                                      
REMARK 465      DT I    15                                                      
REMARK 465      DA I    16                                                      
REMARK 465      DA I    17                                                      
REMARK 465      DC I    18                                                      
REMARK 465      DC I    19                                                      
REMARK 465      DG I    20                                                      
REMARK 465      DC I    21                                                      
REMARK 465      DC I    22                                                      
REMARK 465      DA I    23                                                      
REMARK 465      DA I    24                                                      
REMARK 465      DG I    25                                                      
REMARK 465      DG I    26                                                      
REMARK 465      DG I    27                                                      
REMARK 465      DG I    28                                                      
REMARK 465      DA I    29                                                      
REMARK 465      DT I    30                                                      
REMARK 465      DT I    31                                                      
REMARK 465      DA I    32                                                      
REMARK 465      DC I    33                                                      
REMARK 465      DT I    34                                                      
REMARK 465      DC I    35                                                      
REMARK 465      DC I    36                                                      
REMARK 465      DC I    37                                                      
REMARK 465      DT I    38                                                      
REMARK 465      DA I    39                                                      
REMARK 465      DA I    73                                                      
REMARK 465      DT I    74                                                      
REMARK 465      DA J   -74                                                      
REMARK 465      DT J   -73                                                      
REMARK 465      DT J   -39                                                      
REMARK 465      DA J   -38                                                      
REMARK 465      DG J   -37                                                      
REMARK 465      DG J   -36                                                      
REMARK 465      DG J   -35                                                      
REMARK 465      DA J   -34                                                      
REMARK 465      DG J   -33                                                      
REMARK 465      DT J   -32                                                      
REMARK 465      DA J   -31                                                      
REMARK 465      DA J   -30                                                      
REMARK 465      DT J   -29                                                      
REMARK 465      DC J   -28                                                      
REMARK 465      DC J   -27                                                      
REMARK 465      DC J   -26                                                      
REMARK 465      DC J   -25                                                      
REMARK 465      DT J   -24                                                      
REMARK 465      DT J   -23                                                      
REMARK 465      DG J   -22                                                      
REMARK 465      DG J   -21                                                      
REMARK 465      DC J   -20                                                      
REMARK 465      DG J   -19                                                      
REMARK 465      DG J   -18                                                      
REMARK 465      DT J   -17                                                      
REMARK 465      DT J   -16                                                      
REMARK 465      DA J   -15                                                      
REMARK 465      DA J   -14                                                      
REMARK 465      DA J   -13                                                      
REMARK 465      DA J   -12                                                      
REMARK 465      DC J   -11                                                      
REMARK 465      DG J   -10                                                      
REMARK 465      DC J    -9                                                      
REMARK 465      DG J    -8                                                      
REMARK 465      DG J    -7                                                      
REMARK 465      DG J    -6                                                      
REMARK 465      DG J    -5                                                      
REMARK 465      DG J    -4                                                      
REMARK 465      DA J    -3                                                      
REMARK 465      DC J    -2                                                      
REMARK 465      DA J    -1                                                      
REMARK 465      DG J     0                                                      
REMARK 465      DC J    40                                                      
REMARK 465      DC J    41                                                      
REMARK 465      DA J    42                                                      
REMARK 465      DA J    43                                                      
REMARK 465      DT J    44                                                      
REMARK 465      DT J    45                                                      
REMARK 465      DG J    46                                                      
REMARK 465      DA J    47                                                      
REMARK 465      DG J    48                                                      
REMARK 465      DC J    49                                                      
REMARK 465      DG J    50                                                      
REMARK 465      DG J    51                                                      
REMARK 465      DC J    52                                                      
REMARK 465      DC J    53                                                      
REMARK 465      DT J    54                                                      
REMARK 465      DC J    55                                                      
REMARK 465      DG J    56                                                      
REMARK 465      DG J    57                                                      
REMARK 465      DC J    58                                                      
REMARK 465      DA J    59                                                      
REMARK 465      DC J    60                                                      
REMARK 465      DC J    61                                                      
REMARK 465      DG J    62                                                      
REMARK 465      DG J    63                                                      
REMARK 465      DG J    64                                                      
REMARK 465      DA J    65                                                      
REMARK 465      DT J    66                                                      
REMARK 465      DT J    67                                                      
REMARK 465      DC J    68                                                      
REMARK 465      DT J    69                                                      
REMARK 465      DC J    70                                                      
REMARK 465      DC J    71                                                      
REMARK 465      DG J    72                                                      
REMARK 465      DA J    73                                                      
REMARK 465      DT J    74                                                      
REMARK 465     GLY K     0                                                      
REMARK 465     SER K     1                                                      
REMARK 465     VAL K     2                                                      
REMARK 465     LYS K     3                                                      
REMARK 465     ARG K     4                                                      
REMARK 465     THR K     5                                                      
REMARK 465     VAL K     6                                                      
REMARK 465     ALA K     7                                                      
REMARK 465     THR K     8                                                      
REMARK 465     ASN K     9                                                      
REMARK 465     GLY K    10                                                      
REMARK 465     ASP K    11                                                      
REMARK 465     ALA K    12                                                      
REMARK 465     SER K    13                                                      
REMARK 465     GLY K    14                                                      
REMARK 465     ALA K    15                                                      
REMARK 465     HIS K    16                                                      
REMARK 465     ARG K    17                                                      
REMARK 465     ALA K    18                                                      
REMARK 465     LYS K    19                                                      
REMARK 465     LYS K    20                                                      
REMARK 465     MET K    21                                                      
REMARK 465     SER K    22                                                      
REMARK 465     SER K   121                                                      
REMARK 465     ASN K   122                                                      
REMARK 465     ALA K   123                                                      
REMARK 465     LYS K   124                                                      
REMARK 465     GLU K   125                                                      
REMARK 465     GLN K   126                                                      
REMARK 465     LEU K   127                                                      
REMARK 465     LYS K   128                                                      
REMARK 465     ASP K   129                                                      
REMARK 465     MET K   130                                                      
REMARK 465     ASP K   131                                                      
REMARK 465     ALA K   132                                                      
REMARK 465     ASP K   133                                                      
REMARK 465     ASP K   134                                                      
REMARK 465     SER K   135                                                      
REMARK 465     SER K   136                                                      
REMARK 465     ASP K   137                                                      
REMARK 465     ASP K   138                                                      
REMARK 465     GLU K   139                                                      
REMARK 465     ASP K   140                                                      
REMARK 465     GLY K   141                                                      
REMARK 465     ASP K   142                                                      
REMARK 465     LEU K   143                                                      
REMARK 465     ASN K   144                                                      
REMARK 465     ASN K   250A                                                     
REMARK 465     GLN K   250B                                                     
REMARK 465     LEU K   250C                                                     
REMARK 465     GLY K   250D                                                     
REMARK 465     ARG K   250E                                                     
REMARK 465     LYS K   250F                                                     
REMARK 465     VAL K   250G                                                     
REMARK 465     GLU K   311                                                      
REMARK 465     ASP K   312                                                      
REMARK 465     GLY K   313                                                      
REMARK 465     ALA K   314                                                      
REMARK 465     MET K   478                                                      
REMARK 465     ASP K   479                                                      
REMARK 465     ASP K   480                                                      
REMARK 465     GLY M   151                                                      
REMARK 465     SER M   152                                                      
REMARK 465     ALA M   153                                                      
REMARK 465     LYS M   154                                                      
REMARK 465     GLN M   155                                                      
REMARK 465     ALA M   156                                                      
REMARK 465     LEU M   157                                                      
REMARK 465     LYS M   158                                                      
REMARK 465     LYS M   159                                                      
REMARK 465     PRO M   160                                                      
REMARK 465     ILE M   161                                                      
REMARK 465     LYS M   162                                                      
REMARK 465     GLY M   163                                                      
REMARK 465     LYS M   164                                                      
REMARK 465     GLN M   165                                                      
REMARK 465     ALA M   166                                                      
REMARK 465     PRO M   167                                                      
REMARK 465     ARG M   168                                                      
REMARK 465     LYS M   169                                                      
REMARK 465     LYS M   170                                                      
REMARK 465     ALA M   171                                                      
REMARK 465     GLN M   172                                                      
REMARK 465     GLY M   173                                                      
REMARK 465     LYS M   174                                                      
REMARK 465     THR M   175                                                      
REMARK 465     GLN M   176                                                      
REMARK 465     GLN M   177                                                      
REMARK 465     ASN M   178                                                      
REMARK 465     ARG M   179                                                      
REMARK 465     LYS M   180                                                      
REMARK 465     LEU M   181                                                      
REMARK 465     THR M   182                                                      
REMARK 465     ASP M   183                                                      
REMARK 465     PHE M   184                                                      
REMARK 465     TYR M   185                                                      
REMARK 465     PRO M   186                                                      
REMARK 465     VAL M   187                                                      
REMARK 465     ARG M   188                                                      
REMARK 465     ARG M   189                                                      
REMARK 465     SER M   190                                                      
REMARK 465     SER M   191                                                      
REMARK 465     ARG M   192                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A  37    CG   CD   CE   NZ                                   
REMARK 470     HIS A  39    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ARG A  40    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR A  41    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ARG A  42    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO A  43    CG   CD                                             
REMARK 470     THR A  45    OG1  CG2                                            
REMARK 470     VAL A  46    CG1  CG2                                            
REMARK 470     LEU A  48    CG   CD1  CD2                                       
REMARK 470     ARG A  49    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A  50    CG   CD   OE1  OE2                                  
REMARK 470     ILE A  51    CG1  CG2  CD1                                       
REMARK 470     ARG A  52    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A  53    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR A  54    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN A  55    CG   CD   OE1  NE2                                  
REMARK 470     LYS A  56    CG   CD   CE   NZ                                   
REMARK 470     SER A  57    OG                                                  
REMARK 470     THR A  58    OG1  CG2                                            
REMARK 470     GLU A  59    CG   CD   OE1  OE2                                  
REMARK 470     LEU A  60    CG   CD1  CD2                                       
REMARK 470     LEU A  61    CG   CD1  CD2                                       
REMARK 470     ILE A  62    CG1  CG2  CD1                                       
REMARK 470     ARG A  63    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A  64    CG   CD   CE   NZ                                   
REMARK 470     LEU A  65    CG   CD1  CD2                                       
REMARK 470     PRO A  66    CG   CD                                             
REMARK 470     PHE A  67    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN A  68    CG   CD   OE1  NE2                                  
REMARK 470     ARG A  69    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A  70    CG   CD1  CD2                                       
REMARK 470     VAL A  71    CG1  CG2                                            
REMARK 470     ARG A  72    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A  73    CG   CD   OE1  OE2                                  
REMARK 470     ILE A  74    CG1  CG2  CD1                                       
REMARK 470     GLN A  76    CG   CD   OE1  NE2                                  
REMARK 470     ASP A  77    CG   OD1  OD2                                       
REMARK 470     PHE A  78    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS A  79    CG   CD   CE   NZ                                   
REMARK 470     THR A  80    OG1  CG2                                            
REMARK 470     ASP A  81    CG   OD1  OD2                                       
REMARK 470     LEU A  82    CG   CD1  CD2                                       
REMARK 470     ARG A  83    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE A  84    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN A  85    CG   CD   OE1  NE2                                  
REMARK 470     SER A  86    OG                                                  
REMARK 470     SER A  87    OG                                                  
REMARK 470     VAL A  89    CG1  CG2                                            
REMARK 470     MET A  90    CG   SD   CE                                        
REMARK 470     LEU A  92    CG   CD1  CD2                                       
REMARK 470     GLN A  93    CG   CD   OE1  NE2                                  
REMARK 470     GLU A  94    CG   CD   OE1  OE2                                  
REMARK 470     SER A  96    OG                                                  
REMARK 470     GLU A  97    CG   CD   OE1  OE2                                  
REMARK 470     TYR A  99    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU A 100    CG   CD1  CD2                                       
REMARK 470     VAL A 101    CG1  CG2                                            
REMARK 470     LEU A 103    CG   CD1  CD2                                       
REMARK 470     PHE A 104    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU A 105    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 106    CG   OD1  OD2                                       
REMARK 470     THR A 107    OG1  CG2                                            
REMARK 470     ASN A 108    CG   OD1  ND2                                       
REMARK 470     LEU A 109    CG   CD1  CD2                                       
REMARK 470     CYS A 110    SG                                                  
REMARK 470     ILE A 112    CG1  CG2  CD1                                       
REMARK 470     HIS A 113    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS A 115    CG   CD   CE   NZ                                   
REMARK 470     ARG A 116    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL A 117    CG1  CG2                                            
REMARK 470     THR A 118    OG1  CG2                                            
REMARK 470     ILE A 119    CG1  CG2  CD1                                       
REMARK 470     MET A 120    CG   SD   CE                                        
REMARK 470     PRO A 121    CG   CD                                             
REMARK 470     LYS A 122    CG   CD   CE   NZ                                   
REMARK 470     ASP A 123    CG   OD1  OD2                                       
REMARK 470     ILE A 124    CG1  CG2  CD1                                       
REMARK 470     GLN A 125    CG   CD   OE1  NE2                                  
REMARK 470     LEU A 126    CG   CD1  CD2                                       
REMARK 470     ARG A 128    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE A 130    CG1  CG2  CD1                                       
REMARK 470     ARG A 131    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 133    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 134    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B  24    CG   OD1  OD2                                       
REMARK 470     ASN B  25    CG   OD1  ND2                                       
REMARK 470     ILE B  26    CG1  CG2  CD1                                       
REMARK 470     GLN B  27    CG   CD   OE1  NE2                                  
REMARK 470     ILE B  29    CG1  CG2  CD1                                       
REMARK 470     THR B  30    OG1  CG2                                            
REMARK 470     LYS B  31    CG   CD   CE   NZ                                   
REMARK 470     ILE B  34    CG1  CG2  CD1                                       
REMARK 470     ARG B  35    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B  36    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU B  37    CG   CD1  CD2                                       
REMARK 470     ARG B  39    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B  40    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL B  43    CG1  CG2                                            
REMARK 470     LYS B  44    CG   CD   CE   NZ                                   
REMARK 470     ARG B  45    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE B  46    CG1  CG2  CD1                                       
REMARK 470     SER B  47    OG                                                  
REMARK 470     LEU B  49    CG   CD1  CD2                                       
REMARK 470     ILE B  50    CG1  CG2  CD1                                       
REMARK 470     TYR B  51    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU B  52    CG   CD   OE1  OE2                                  
REMARK 470     GLU B  53    CG   CD   OE1  OE2                                  
REMARK 470     THR B  54    OG1  CG2                                            
REMARK 470     ARG B  55    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL B  57    CG1  CG2                                            
REMARK 470     LEU B  58    CG   CD1  CD2                                       
REMARK 470     LYS B  59    CG   CD   CE   NZ                                   
REMARK 470     VAL B  60    CG1  CG2                                            
REMARK 470     PHE B  61    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU B  62    CG   CD1  CD2                                       
REMARK 470     GLU B  63    CG   CD   OE1  OE2                                  
REMARK 470     ASN B  64    CG   OD1  ND2                                       
REMARK 470     VAL B  65    CG1  CG2                                            
REMARK 470     ILE B  66    CG1  CG2  CD1                                       
REMARK 470     ARG B  67    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B  68    CG   OD1  OD2                                       
REMARK 470     VAL B  70    CG1  CG2                                            
REMARK 470     THR B  71    OG1  CG2                                            
REMARK 470     TYR B  72    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     THR B  73    OG1  CG2                                            
REMARK 470     GLU B  74    CG   CD   OE1  OE2                                  
REMARK 470     HIS B  75    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS B  77    CG   CD   CE   NZ                                   
REMARK 470     ARG B  78    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B  79    CG   CD   CE   NZ                                   
REMARK 470     THR B  80    OG1  CG2                                            
REMARK 470     VAL B  81    CG1  CG2                                            
REMARK 470     THR B  82    OG1  CG2                                            
REMARK 470     MET B  84    CG   SD   CE                                        
REMARK 470     ASP B  85    CG   OD1  OD2                                       
REMARK 470     VAL B  86    CG1  CG2                                            
REMARK 470     VAL B  87    CG1  CG2                                            
REMARK 470     TYR B  88    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU B  90    CG   CD1  CD2                                       
REMARK 470     LYS B  91    CG   CD   CE   NZ                                   
REMARK 470     ARG B  92    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN B  93    CG   CD   OE1  NE2                                  
REMARK 470     ARG B  95    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR B  96    OG1  CG2                                            
REMARK 470     LEU B  97    CG   CD1  CD2                                       
REMARK 470     TYR B  98    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     PHE B 100    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS G  15    CG   CD   CE   NZ                                   
REMARK 470     THR G  16    OG1  CG2                                            
REMARK 470     ARG G  17    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER G  18    OG                                                  
REMARK 470     SER G  19    OG                                                  
REMARK 470     ARG G  20    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU G  23    CG   CD1  CD2                                       
REMARK 470     GLN G  24    CG   CD   OE1  NE2                                  
REMARK 470     PHE G  25    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO G  26    CG   CD                                             
REMARK 470     VAL G  27    CG1  CG2                                            
REMARK 470     ARG G  29    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL G  30    CG1  CG2                                            
REMARK 470     HIS G  31    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ARG G  32    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU G  33    CG   CD1  CD2                                       
REMARK 470     LEU G  34    CG   CD1  CD2                                       
REMARK 470     ARG G  35    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G  36    CG   CD   CE   NZ                                   
REMARK 470     ASN G  38    CG   OD1  ND2                                       
REMARK 470     TYR G  39    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU G  41    CG   CD   OE1  OE2                                  
REMARK 470     ARG G  42    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL G  43    CG1  CG2                                            
REMARK 470     PRO G  48    CG   CD                                             
REMARK 470     VAL G  49    CG1  CG2                                            
REMARK 470     TYR G  50    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU G  51    CG   CD1  CD2                                       
REMARK 470     VAL G  54    CG1  CG2                                            
REMARK 470     LEU G  55    CG   CD1  CD2                                       
REMARK 470     GLU G  56    CG   CD   OE1  OE2                                  
REMARK 470     TYR G  57    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU G  58    CG   CD1  CD2                                       
REMARK 470     THR G  59    OG1  CG2                                            
REMARK 470     GLU G  61    CG   CD   OE1  OE2                                  
REMARK 470     ILE G  62    CG1  CG2  CD1                                       
REMARK 470     LEU G  63    CG   CD1  CD2                                       
REMARK 470     GLU G  64    CG   CD   OE1  OE2                                  
REMARK 470     LEU G  65    CG   CD1  CD2                                       
REMARK 470     ASN G  68    CG   OD1  ND2                                       
REMARK 470     ARG G  71    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP G  72    CG   OD1  OD2                                       
REMARK 470     ASN G  73    CG   OD1  ND2                                       
REMARK 470     LYS G  74    CG   CD   CE   NZ                                   
REMARK 470     LYS G  75    CG   CD   CE   NZ                                   
REMARK 470     THR G  76    OG1  CG2                                            
REMARK 470     ARG G  77    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE G  78    CG1  CG2  CD1                                       
REMARK 470     ILE G  79    CG1  CG2  CD1                                       
REMARK 470     PRO G  80    CG   CD                                             
REMARK 470     ARG G  81    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS G  82    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU G  83    CG   CD1  CD2                                       
REMARK 470     GLN G  84    CG   CD   OE1  NE2                                  
REMARK 470     LEU G  85    CG   CD1  CD2                                       
REMARK 470     VAL G  87    CG1  CG2                                            
REMARK 470     ARG G  88    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN G  89    CG   OD1  ND2                                       
REMARK 470     ASP G  90    CG   OD1  OD2                                       
REMARK 470     GLU G  91    CG   CD   OE1  OE2                                  
REMARK 470     GLU G  92    CG   CD   OE1  OE2                                  
REMARK 470     LEU G  93    CG   CD1  CD2                                       
REMARK 470     ASN G  94    CG   OD1  ND2                                       
REMARK 470     LYS G  95    CG   CD   CE   NZ                                   
REMARK 470     LEU G  96    CG   CD1  CD2                                       
REMARK 470     LEU G  97    CG   CD1  CD2                                       
REMARK 470     ARG G  99    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL G 100    CG1  CG2                                            
REMARK 470     THR G 101    OG1  CG2                                            
REMARK 470     ILE G 102    CG1  CG2  CD1                                       
REMARK 470     GLN G 104    CG   CD   OE1  NE2                                  
REMARK 470     VAL G 107    CG1  CG2                                            
REMARK 470     LEU G 108    CG   CD1  CD2                                       
REMARK 470     PRO G 109    CG   CD                                             
REMARK 470     ASN G 110    CG   OD1  ND2                                       
REMARK 470     ILE G 111    CG1  CG2  CD1                                       
REMARK 470     GLN G 112    CG   CD   OE1  NE2                                  
REMARK 470     SER G 113    OG                                                  
REMARK 470     VAL G 114    CG1  CG2                                            
REMARK 470     LEU G 115    CG   CD1  CD2                                       
REMARK 470     LEU G 116    CG   CD1  CD2                                       
REMARK 470     PRO G 117    CG   CD                                             
REMARK 470     LYS G 118    CG   CD   CE   NZ                                   
REMARK 470     LYS G 119    CG   CD   CE   NZ                                   
REMARK 470     LYS H  28    CG   CD   CE   NZ                                   
REMARK 470     THR H  29    OG1  CG2                                            
REMARK 470     ARG H  30    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS H  31    CG   CD   CE   NZ                                   
REMARK 470     GLU H  32    CG   CD   OE1  OE2                                  
REMARK 470     SER H  33    OG                                                  
REMARK 470     TYR H  34    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE H  36    CG1  CG2  CD1                                       
REMARK 470     TYR H  37    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     VAL H  38    CG1  CG2                                            
REMARK 470     TYR H  39    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS H  40    CG   CD   CE   NZ                                   
REMARK 470     VAL H  41    CG1  CG2                                            
REMARK 470     LEU H  42    CG   CD1  CD2                                       
REMARK 470     LYS H  43    CG   CD   CE   NZ                                   
REMARK 470     GLN H  44    CG   CD   OE1  NE2                                  
REMARK 470     VAL H  45    CG1  CG2                                            
REMARK 470     HIS H  46    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP H  48    CG   OD1  OD2                                       
REMARK 470     THR H  49    OG1  CG2                                            
REMARK 470     ILE H  51    CG1  CG2  CD1                                       
REMARK 470     SER H  52    OG                                                  
REMARK 470     SER H  53    OG                                                  
REMARK 470     LYS H  54    CG   CD   CE   NZ                                   
REMARK 470     MET H  56    CG   SD   CE                                        
REMARK 470     SER H  57    OG                                                  
REMARK 470     ILE H  58    CG1  CG2  CD1                                       
REMARK 470     MET H  59    CG   SD   CE                                        
REMARK 470     ASN H  60    CG   OD1  ND2                                       
REMARK 470     SER H  61    OG                                                  
REMARK 470     PHE H  62    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     VAL H  63    CG1  CG2                                            
REMARK 470     ASN H  64    CG   OD1  ND2                                       
REMARK 470     ASP H  65    CG   OD1  OD2                                       
REMARK 470     VAL H  66    CG1  CG2                                            
REMARK 470     PHE H  67    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU H  68    CG   CD   OE1  OE2                                  
REMARK 470     ARG H  69    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE H  70    CG1  CG2  CD1                                       
REMARK 470     GLU H  73    CG   CD   OE1  OE2                                  
REMARK 470     SER H  75    OG                                                  
REMARK 470     ARG H  76    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU H  77    CG   CD1  CD2                                       
REMARK 470     HIS H  79    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TYR H  80    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN H  81    CG   OD1  ND2                                       
REMARK 470     LYS H  82    CG   CD   CE   NZ                                   
REMARK 470     ARG H  83    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER H  84    OG                                                  
REMARK 470     THR H  85    OG1  CG2                                            
REMARK 470     ILE H  86    CG1  CG2  CD1                                       
REMARK 470     THR H  87    OG1  CG2                                            
REMARK 470     SER H  88    OG                                                  
REMARK 470     ARG H  89    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H  90    CG   CD   OE1  OE2                                  
REMARK 470     ILE H  91    CG1  CG2  CD1                                       
REMARK 470     GLN H  92    CG   CD   OE1  NE2                                  
REMARK 470     THR H  93    OG1  CG2                                            
REMARK 470     VAL H  95    CG1  CG2                                            
REMARK 470     ARG H  96    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU H  97    CG   CD1  CD2                                       
REMARK 470     LEU H  98    CG   CD1  CD2                                       
REMARK 470     LEU H  99    CG   CD1  CD2                                       
REMARK 470     PRO H 100    CG   CD                                             
REMARK 470     GLU H 102    CG   CD   OE1  OE2                                  
REMARK 470     LEU H 103    CG   CD1  CD2                                       
REMARK 470     LYS H 105    CG   CD   CE   NZ                                   
REMARK 470     HIS H 106    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL H 108    CG1  CG2                                            
REMARK 470     SER H 109    OG                                                  
REMARK 470     GLU H 110    CG   CD   OE1  OE2                                  
REMARK 470     THR H 112    OG1  CG2                                            
REMARK 470     LYS H 113    CG   CD   CE   NZ                                   
REMARK 470     VAL H 115    CG1  CG2                                            
REMARK 470     THR H 116    OG1  CG2                                            
REMARK 470     LYS H 117    CG   CD   CE   NZ                                   
REMARK 470     TYR H 118    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     THR H 119    OG1  CG2                                            
REMARK 470     SER H 120    OG                                                  
REMARK 470     LYS H 122    CG   CD   CE   NZ                                   
REMARK 470     LYS K  23    CG   CD   CE   NZ                                   
REMARK 470     THR K  24    OG1  CG2                                            
REMARK 470     HIS K  25    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER K  27    OG                                                  
REMARK 470     HIS K  28    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE K  29    CG1  CG2  CD1                                       
REMARK 470     ILE K  30    CG1  CG2  CD1                                       
REMARK 470     ASN K  31    CG   OD1  ND2                                       
REMARK 470     GLN K  33    CG   CD   OE1  NE2                                  
REMARK 470     GLU K  34    CG   CD   OE1  OE2                                  
REMARK 470     ASP K  35    CG   OD1  OD2                                       
REMARK 470     TYR K  36    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS K  37    CG   CD   CE   NZ                                   
REMARK 470     HIS K  38    CG   ND1  CD2  CE1  NE2                             
REMARK 470     MET K  39    CG   SD   CE                                        
REMARK 470     TYR K  40    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU K  41    CG   CD1  CD2                                       
REMARK 470     SER K  42    OG                                                  
REMARK 470     VAL K  43    CG1  CG2                                            
REMARK 470     GLN K  44    CG   CD   OE1  NE2                                  
REMARK 470     LEU K  46    CG   CD1  CD2                                       
REMARK 470     ASP K  47    CG   OD1  OD2                                       
REMARK 470     ILE K  48    CG1  CG2  CD1                                       
REMARK 470     PHE K  49    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     CYS K  50    SG                                                  
REMARK 470     TRP K  51    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP K  51    CZ3  CH2                                            
REMARK 470     THR K  53    OG1  CG2                                            
REMARK 470     SER K  55    OG                                                  
REMARK 470     MET K  56    CG   SD   CE                                        
REMARK 470     CYS K  57    SG                                                  
REMARK 470     GLU K  58    CG   CD   OE1  OE2                                  
REMARK 470     LEU K  59    CG   CD1  CD2                                       
REMARK 470     LEU K  61    CG   CD1  CD2                                       
REMARK 470     LEU K  64    CG   CD1  CD2                                       
REMARK 470     LYS K  66    CG   CD   CE   NZ                                   
REMARK 470     ASN K  67    CG   OD1  ND2                                       
REMARK 470     LYS K  68    CG   CD   CE   NZ                                   
REMARK 470     GLU K  69    CG   CD   OE1  OE2                                  
REMARK 470     VAL K  70    CG1  CG2                                            
REMARK 470     LYS K  71    CG   CD   CE   NZ                                   
REMARK 470     ARG K  72    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG K  74    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU K  75    CG   CD1  CD2                                       
REMARK 470     ASN K  76    CG   OD1  ND2                                       
REMARK 470     PHE K  78    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU K  79    CG   CD1  CD2                                       
REMARK 470     ARG K  81    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP K  82    CG   OD1  OD2                                       
REMARK 470     GLU K  83    CG   CD   OE1  OE2                                  
REMARK 470     LYS K  85    CG   CD   CE   NZ                                   
REMARK 470     ILE K  86    CG1  CG2  CD1                                       
REMARK 470     ILE K  87    CG1  CG2  CD1                                       
REMARK 470     SER K  88    OG                                                  
REMARK 470     PHE K  89    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     VAL K  91    CG1  CG2                                            
REMARK 470     MET K  94    CG   SD   CE                                        
REMARK 470     HIS K  95    CG   ND1  CD2  CE1  NE2                             
REMARK 470     THR K  96    OG1  CG2                                            
REMARK 470     LEU K  97    CG   CD1  CD2                                       
REMARK 470     LEU K  99    CG   CD1  CD2                                       
REMARK 470     ASP K 100    CG   OD1  OD2                                       
REMARK 470     GLU K 101    CG   CD   OE1  OE2                                  
REMARK 470     GLU K 102    CG   CD   OE1  OE2                                  
REMARK 470     SER K 103    CB   OG                                             
REMARK 470     ASN K 104    CG   OD1  ND2                                       
REMARK 470     VAL K 105    CG1  CG2                                            
REMARK 470     TRP K 106    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP K 106    CZ3  CH2                                            
REMARK 470     SER K 107    OG                                                  
REMARK 470     TRP K 108    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP K 108    CZ3  CH2                                            
REMARK 470     CYS K 110    SG                                                  
REMARK 470     ASN K 111    CG   OD1  ND2                                       
REMARK 470     ASP K 112    CG   OD1  OD2                                       
REMARK 470     VAL K 113    CG1  CG2                                            
REMARK 470     LEU K 116    CG   CD1  CD2                                       
REMARK 470     ARG K 118    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP K 119    CG   OD1  OD2                                       
REMARK 470     THR K 120    OG1  CG2                                            
REMARK 470     GLU K 145    CG   CD   OE1  OE2                                  
REMARK 470     LEU K 146    CG   CD1  CD2                                       
REMARK 470     GLU K 147    CG   CD   OE1  OE2                                  
REMARK 470     SER K 148    OG                                                  
REMARK 470     THR K 149    OG1  CG2                                            
REMARK 470     LYS K 152    CG   CD   CE   NZ                                   
REMARK 470     ILE K 153    CG1  CG2  CD1                                       
REMARK 470     ARG K 155    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU K 156    CG   CD   OE1  OE2                                  
REMARK 470     SER K 157    OG                                                  
REMARK 470     PHE K 158    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU K 161    CG   CD1  CD2                                       
REMARK 470     GLU K 163    CG   CD   OE1  OE2                                  
REMARK 470     HIS K 165    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS K 166    CG   CD   CE   NZ                                   
REMARK 470     VAL K 167    CG1  CG2                                            
REMARK 470     VAL K 168    CG1  CG2                                            
REMARK 470     GLN K 169    CG   CD   OE1  NE2                                  
REMARK 470     LEU K 170    CG   CD1  CD2                                       
REMARK 470     THR K 173    OG1  CG2                                            
REMARK 470     ASP K 174    CG   OD1  OD2                                       
REMARK 470     ASN K 175    CG   OD1  ND2                                       
REMARK 470     MET K 176    CG   SD   CE                                        
REMARK 470     SER K 177    OG                                                  
REMARK 470     CYS K 178    SG                                                  
REMARK 470     LEU K 180    CG   CD1  CD2                                       
REMARK 470     PHE K 181    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER K 182    OG                                                  
REMARK 470     ASN K 183    CG   OD1  ND2                                       
REMARK 470     GLU K 185    CG   CD   OE1  OE2                                  
REMARK 470     VAL K 186    CG1  CG2                                            
REMARK 470     TYR K 187    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TRP K 189    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP K 189    CZ3  CH2                                            
REMARK 470     THR K 191    OG1  CG2                                            
REMARK 470     PHE K 192    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG K 193    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     CYS K 194    SG                                                  
REMARK 470     ASN K 195    CG   OD1  ND2                                       
REMARK 470     GLU K 196    CG   CD   OE1  OE2                                  
REMARK 470     ILE K 198    CG1  CG2  CD1                                       
REMARK 470     LEU K 199    CG   CD1  CD2                                       
REMARK 470     PHE K 201    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TYR K 202    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN K 203    CG   CD   OE1  NE2                                  
REMARK 470     ASP K 204    CG   OD1  OD2                                       
REMARK 470     LYS K 205    CG   CD   CE   NZ                                   
REMARK 470     ILE K 206    CG1  CG2  CD1                                       
REMARK 470     LYS K 207    CG   CD   CE   NZ                                   
REMARK 470     ILE K 208    CG1  CG2  CD1                                       
REMARK 470     GLN K 209    CG   CD   OE1  NE2                                  
REMARK 470     LYS K 210    CG   CD   CE   NZ                                   
REMARK 470     THR K 211    OG1  CG2                                            
REMARK 470     TRP K 213    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP K 213    CZ3  CH2                                            
REMARK 470     LYS K 214    CG   CD   CE   NZ                                   
REMARK 470     VAL K 215    CG1  CG2                                            
REMARK 470     THR K 217    OG1  CG2                                            
REMARK 470     PHE K 218    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER K 219    OG                                                  
REMARK 470     LYS K 220    CG   CD   CE   NZ                                   
REMARK 470     TYR K 221    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN K 222    CG   OD1  ND2                                       
REMARK 470     ILE K 223    CG1  CG2  CD1                                       
REMARK 470     VAL K 224    CG1  CG2                                            
REMARK 470     GLN K 225    CG   CD   OE1  NE2                                  
REMARK 470     LEU K 226    CG   CD1  CD2                                       
REMARK 470     LYS K 230    CG   CD   CE   NZ                                   
REMARK 470     ASP K 231    CG   OD1  OD2                                       
REMARK 470     HIS K 232    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE K 233    CG1  CG2  CD1                                       
REMARK 470     LEU K 234    CG   CD1  CD2                                       
REMARK 470     PHE K 235    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU K 236    CG   CD1  CD2                                       
REMARK 470     ASP K 237    CG   OD1  OD2                                       
REMARK 470     GLU K 238    CG   CD   OE1  OE2                                  
REMARK 470     GLU K 239    CG   CD   OE1  OE2                                  
REMARK 470     MET K 241    CG   SD   CE                                        
REMARK 470     VAL K 242    CG1  CG2                                            
REMARK 470     PHE K 243    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TRP K 245    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP K 245    CZ3  CH2                                            
REMARK 470     ASN K 247    CG   OD1  ND2                                       
REMARK 470     GLN K 249    CG   CD   OE1  NE2                                  
REMARK 470     GLN K 250    CG   CD   OE1  NE2                                  
REMARK 470     MET K 256    CG   SD   CE                                        
REMARK 470     GLU K 257    CG   CD   OE1  OE2                                  
REMARK 470     ARG K 258    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE K 259    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG K 260    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU K 261    CG   CD1  CD2                                       
REMARK 470     LYS K 262    CG   CD   CE   NZ                                   
REMARK 470     THR K 263    OG1  CG2                                            
REMARK 470     LEU K 264    CG   CD1  CD2                                       
REMARK 470     ASP K 265    CG   OD1  OD2                                       
REMARK 470     ARG K 267    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE K 269    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU K 271    CG   CD1  CD2                                       
REMARK 470     ARG K 272    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS K 273    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL K 274    CG1  CG2                                            
REMARK 470     LYS K 275    CG   CD   CE   NZ                                   
REMARK 470     TYR K 276    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE K 277    CG1  CG2  CD1                                       
REMARK 470     SER K 279    OG                                                  
REMARK 470     GLU K 281    CG   CD   OE1  OE2                                  
REMARK 470     ASN K 282    CG   OD1  ND2                                       
REMARK 470     HIS K 283    CG   ND1  CD2  CE1  NE2                             
REMARK 470     CYS K 284    SG                                                  
REMARK 470     PHE K 285    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU K 287    CG   CD1  CD2                                       
REMARK 470     THR K 288    OG1  CG2                                            
REMARK 470     LYS K 289    CG   CD   CE   NZ                                   
REMARK 470     ASP K 290    CG   OD1  OD2                                       
REMARK 470     ASN K 291    CG   OD1  ND2                                       
REMARK 470     LYS K 292    CG   CD   CE   NZ                                   
REMARK 470     LEU K 293    CG   CD1  CD2                                       
REMARK 470     VAL K 294    CG1  CG2                                            
REMARK 470     SER K 295    OG                                                  
REMARK 470     TRP K 296    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP K 296    CZ3  CH2                                            
REMARK 470     LEU K 298    CG   CD1  CD2                                       
REMARK 470     ASN K 299    CG   OD1  ND2                                       
REMARK 470     GLN K 300    CG   CD   OE1  NE2                                  
REMARK 470     PHE K 301    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN K 303    CG   CD   OE1  NE2                                  
REMARK 470     CYS K 304    SG                                                  
REMARK 470     VAL K 306    CG1  CG2                                            
REMARK 470     SER K 307    OG                                                  
REMARK 470     GLU K 308    CG   CD   OE1  OE2                                  
REMARK 470     ASP K 309    CG   OD1  OD2                                       
REMARK 470     VAL K 310    CG1  CG2                                            
REMARK 470     LEU K 315    CG   CD1  CD2                                       
REMARK 470     VAL K 316    CG1  CG2                                            
REMARK 470     THR K 317    OG1  CG2                                            
REMARK 470     LYS K 318    CG   CD   CE   NZ                                   
REMARK 470     LYS K 320    CG   CD   CE   NZ                                   
REMARK 470     ARG K 321    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU K 322    CG   CD1  CD2                                       
REMARK 470     LEU K 324    CG   CD1  CD2                                       
REMARK 470     ASP K 326    CG   OD1  OD2                                       
REMARK 470     ASN K 327    CG   OD1  ND2                                       
REMARK 470     VAL K 328    CG1  CG2                                            
REMARK 470     VAL K 329    CG1  CG2                                            
REMARK 470     ILE K 330    CG1  CG2  CD1                                       
REMARK 470     ARG K 331    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER K 332    OG                                                  
REMARK 470     ILE K 333    CG1  CG2  CD1                                       
REMARK 470     GLU K 337    CG   CD   OE1  OE2                                  
REMARK 470     HIS K 338    CG   ND1  CD2  CE1  NE2                             
REMARK 470     HIS K 339    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER K 340    OG                                                  
REMARK 470     LEU K 341    CG   CD1  CD2                                       
REMARK 470     ILE K 342    CG1  CG2  CD1                                       
REMARK 470     LEU K 343    CG   CD1  CD2                                       
REMARK 470     SER K 344    OG                                                  
REMARK 470     GLN K 345    CG   CD   OE1  NE2                                  
REMARK 470     ASP K 346    CG   OD1  OD2                                       
REMARK 470     ASP K 348    CG   OD1  OD2                                       
REMARK 470     LEU K 349    CG   CD1  CD2                                       
REMARK 470     TYR K 350    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER K 351    OG                                                  
REMARK 470     CYS K 352    SG                                                  
REMARK 470     ARG K 354    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU K 355    CG   CD1  CD2                                       
REMARK 470     ASP K 356    CG   OD1  OD2                                       
REMARK 470     MET K 357    CG   SD   CE                                        
REMARK 470     PHE K 358    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU K 359    CG   CD   OE1  OE2                                  
REMARK 470     VAL K 360    CG1  CG2                                            
REMARK 470     ILE K 362    CG1  CG2  CD1                                       
REMARK 470     LYS K 364    CG   CD   CE   NZ                                   
REMARK 470     ASP K 365    CG   OD1  OD2                                       
REMARK 470     ASN K 366    CG   OD1  ND2                                       
REMARK 470     LEU K 367    CG   CD1  CD2                                       
REMARK 470     GLU K 369    CG   CD   OE1  OE2                                  
REMARK 470     TYR K 370    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     THR K 371    OG1  CG2                                            
REMARK 470     TYR K 372    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS K 373    CG   CD   CE   NZ                                   
REMARK 470     ASP K 374    CG   OD1  OD2                                       
REMARK 470     VAL K 375    CG1  CG2                                            
REMARK 470     HIS K 376    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS K 378    CG   CD   CE   NZ                                   
REMARK 470     ARG K 380    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL K 382    CG1  CG2                                            
REMARK 470     LEU K 384    CG   CD1  CD2                                       
REMARK 470     THR K 386    CB   OG1  CG2                                       
REMARK 470     LYS K 387    CB   CG   CD   CE   NZ                              
REMARK 470     LEU K 388    CG   CD1  CD2                                       
REMARK 470     ASN K 389    CG   OD1  ND2                                       
REMARK 470     ASN K 390    CG   OD1  ND2                                       
REMARK 470     VAL K 391    CG1  CG2                                            
REMARK 470     PRO K 392    CG   CD                                             
REMARK 470     LYS K 393    CG   CD   CE   NZ                                   
REMARK 470     PHE K 394    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS K 395    CG   CD   CE   NZ                                   
REMARK 470     SER K 396    OG                                                  
REMARK 470     VAL K 397    CG1  CG2                                            
REMARK 470     SER K 401    OG                                                  
REMARK 470     HIS K 402    CG   ND1  CD2  CE1  NE2                             
REMARK 470     HIS K 403    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER K 404    OG                                                  
REMARK 470     VAL K 405    CG1  CG2                                            
REMARK 470     VAL K 407    CG1  CG2                                            
REMARK 470     GLN K 409    CG   CD   OE1  NE2                                  
REMARK 470     ASN K 410    CG   OD1  ND2                                       
REMARK 470     ILE K 412    CG1  CG2  CD1                                       
REMARK 470     TYR K 414    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER K 415    OG                                                  
REMARK 470     TRP K 416    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP K 416    CZ3  CH2                                            
REMARK 470     PHE K 418    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU K 420    CG   CD   OE1  OE2                                  
REMARK 470     THR K 421    OG1  CG2                                            
REMARK 470     TYR K 422    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     VAL K 424    CG1  CG2                                            
REMARK 470     LEU K 426    CG   CD1  CD2                                       
REMARK 470     PHE K 429    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU K 430    CG   CD   OE1  OE2                                  
REMARK 470     ASP K 431    CG   OD1  OD2                                       
REMARK 470     ASP K 432    CG   OD1  OD2                                       
REMARK 470     THR K 433    OG1  CG2                                            
REMARK 470     GLU K 434    CG   CD   OE1  OE2                                  
REMARK 470     VAL K 435    CG1  CG2                                            
REMARK 470     THR K 437    OG1  CG2                                            
REMARK 470     ARG K 438    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE K 439    CG1  CG2  CD1                                       
REMARK 470     LYS K 440    CG   CD   CE   NZ                                   
REMARK 470     ASN K 441    CG   OD1  ND2                                       
REMARK 470     THR K 442    OG1  CG2                                            
REMARK 470     THR K 444    OG1  CG2                                            
REMARK 470     GLN K 445    CG   CD   OE1  NE2                                  
REMARK 470     ASP K 446    CG   OD1  OD2                                       
REMARK 470     HIS K 447    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN K 448    CG   OD1  ND2                                       
REMARK 470     ILE K 449    CG1  CG2  CD1                                       
REMARK 470     ILE K 450    CG1  CG2  CD1                                       
REMARK 470     LEU K 451    CG   CD1  CD2                                       
REMARK 470     VAL K 452    CG1  CG2                                            
REMARK 470     CYS K 454    SG                                                  
REMARK 470     GLN K 457    CG   CD   OE1  NE2                                  
REMARK 470     PHE K 458    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER K 459    OG                                                  
REMARK 470     VAL K 460    CG1  CG2                                            
REMARK 470     SER K 461    OG                                                  
REMARK 470     VAL K 464    CG1  CG2                                            
REMARK 470     LYS K 465    CG   CD   CE   NZ                                   
REMARK 470     LEU K 466    CG   CD1  CD2                                       
REMARK 470     SER K 467    OG                                                  
REMARK 470     ASP K 468    CG   OD1  OD2                                       
REMARK 470     GLU K 469    CG   CD   OE1  OE2                                  
REMARK 470     ASP K 470    CG   OD1  OD2                                       
REMARK 470     GLU K 472    CG   CD   OE1  OE2                                  
REMARK 470     LYS K 473    CG   CD   CE   NZ                                   
REMARK 470     ARG K 474    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP K 476    CG   OD1  OD2                                       
REMARK 470     GLU K 477    CG   CD   OE1  OE2                                  
REMARK 470     LYS M 193    CG   CD   CE   NZ                                   
REMARK 470     SER M 194    OG                                                  
REMARK 470     LYS M 195    CG   CD   CE   NZ                                   
REMARK 470     GLU M 197    CG   CD   OE1  OE2                                  
REMARK 470     LEU M 198    CG   CD1  CD2                                       
REMARK 470     GLN M 199    CG   CD   OE1  NE2                                  
REMARK 470     SER M 200    OG                                                  
REMARK 470     GLU M 201    CG   CD   OE1  OE2                                  
REMARK 470     GLU M 202    CG   CD   OE1  OE2                                  
REMARK 470     ARG M 203    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS M 204    CG   CD   CE   NZ                                   
REMARK 470     ARG M 205    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE M 206    CG1  CG2  CD1                                       
REMARK 470     ASP M 207    CG   OD1  OD2                                       
REMARK 470     GLU M 208    CG   CD   OE1  OE2                                  
REMARK 470     LEU M 209    CG   CD1  CD2                                       
REMARK 470     ILE M 210    CG1  CG2  CD1                                       
REMARK 470     GLU M 211    CG   CD   OE1  OE2                                  
REMARK 470     SER M 212    OG                                                  
REMARK 470     LYS M 214    CG   CD   CE   NZ                                   
REMARK 470     GLU M 215    CG   CD   OE1  OE2                                  
REMARK 470     GLU M 216    CG   CD   OE1  OE2                                  
REMARK 470     MET M 218    CG   SD   CE                                        
REMARK 470     LYS M 219    CG   CD   CE   NZ                                   
REMARK 470     ILE M 220    CG1  CG2  CD1                                       
REMARK 470     ASP M 221    CG   OD1  OD2                                       
REMARK 470     LEU M 222    CG   CD1  CD2                                       
REMARK 470     ILE M 223    CG1  CG2  CD1                                       
REMARK 470     ASP M 224    CG   OD1  OD2                                       
REMARK 470     LYS M 226    CG   CD   CE   NZ                                   
REMARK 470     ARG M 228    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL M 230    CG1  CG2                                            
REMARK 470     ILE M 231    CG1  CG2  CD1                                       
REMARK 470     THR M 233    OG1  CG2                                            
REMARK 470     LYS M 234    CG   CD   CE   NZ                                   
REMARK 470     GLN M 235    CG   CD   OE1  NE2                                  
REMARK 470     PHE M 236    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER M 237    OG                                                  
REMARK 470     ARG M 238    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP M 240    CG   OD1  OD2                                       
REMARK 470     PHE M 241    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     VAL M 242    CG1  CG2                                            
REMARK 470     VAL M 243    CG1  CG2                                            
REMARK 470     GLU M 244    CG   CD   OE1  OE2                                  
REMARK 470     TYR M 245    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     HIS M 246    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP M 248    CG   OD1  OD2                                       
REMARK 470     LEU M 249    CG   CD1  CD2                                       
REMARK 470     ILE M 250    CG1  CG2  CD1                                       
REMARK 470     GLU M 251    CG   CD   OE1  OE2                                  
REMARK 470     ILE M 252    CG1  CG2  CD1                                       
REMARK 470     THR M 253    OG1  CG2                                            
REMARK 470     ASP M 254    CG   OD1  OD2                                       
REMARK 470     LYS M 256    CG   CD   CE   NZ                                   
REMARK 470     LYS M 257    CG   CD   CE   NZ                                   
REMARK 470     ARG M 258    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU M 259    CG   CD   OE1  OE2                                  
REMARK 470     LEU M 261    CG   CD1  CD2                                       
REMARK 470     TYR M 262    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN M 264    CG   CD   OE1  NE2                                  
REMARK 470     ASP M 265    CG   OD1  OD2                                       
REMARK 470     PRO M 266    CG   CD                                             
REMARK 470     SER M 267    OG                                                  
REMARK 470     THR M 268    OG1  CG2                                            
REMARK 470     CYS M 270    SG                                                  
REMARK 470     TYR M 271    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     MET M 272    CG   SD   CE                                        
REMARK 470     TYR M 273    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TYR M 274    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     PHE M 275    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN M 276    CG   CD   OE1  NE2                                  
REMARK 470     TYR M 277    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU M 278    CG   CD1  CD2                                       
REMARK 470     SER M 279    OG                                                  
REMARK 470     LYS M 280    CG   CD   CE   NZ                                   
REMARK 470     THR M 281    OG1  CG2                                            
REMARK 470     TYR M 282    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     CYS M 283    SG                                                  
REMARK 470     VAL M 284    CG1  CG2                                            
REMARK 470     ASP M 285    CG   OD1  OD2                                       
REMARK 470     THR M 287    OG1  CG2                                            
REMARK 470     ARG M 288    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU M 289    CG   CD   OE1  OE2                                  
REMARK 470     THR M 290    OG1  CG2                                            
REMARK 470     ASN M 291    CG   OD1  ND2                                       
REMARK 470     ARG M 292    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU M 293    CG   CD1  CD2                                       
REMARK 470     ARG M 295    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU M 296    CG   CD1  CD2                                       
REMARK 470     ILE M 297    CG1  CG2  CD1                                       
REMARK 470     ASN M 298    CG   OD1  ND2                                       
REMARK 470     HIS M 299    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER M 300    OG                                                  
REMARK 470     LYS M 301    CG   CD   CE   NZ                                   
REMARK 470     CYS M 302    SG                                                  
REMARK 470     ASN M 304    CG   OD1  ND2                                       
REMARK 470     CYS M 305    SG                                                  
REMARK 470     GLN M 306    CG   CD   OE1  NE2                                  
REMARK 470     THR M 307    OG1  CG2                                            
REMARK 470     LYS M 308    CG   CD   CE   NZ                                   
REMARK 470     LEU M 309    CG   CD1  CD2                                       
REMARK 470     HIS M 310    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP M 311    CG   OD1  OD2                                       
REMARK 470     ILE M 312    CG1  CG2  CD1                                       
REMARK 470     ASP M 313    CG   OD1  OD2                                       
REMARK 470     VAL M 315    CG1  CG2                                            
REMARK 470     PRO M 316    CG   CD                                             
REMARK 470     HIS M 317    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU M 318    CG   CD1  CD2                                       
REMARK 470     ILE M 319    CG1  CG2  CD1                                       
REMARK 470     LEU M 320    CG   CD1  CD2                                       
REMARK 470     ILE M 321    CG1  CG2  CD1                                       
REMARK 470     SER M 323    OG                                                  
REMARK 470     ARG M 324    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP M 325    CG   OD1  OD2                                       
REMARK 470     ILE M 326    CG1  CG2  CD1                                       
REMARK 470     GLU M 330    CG   CD   OE1  OE2                                  
REMARK 470     GLU M 331    CG   CD   OE1  OE2                                  
REMARK 470     LEU M 332    CG   CD1  CD2                                       
REMARK 470     LEU M 333    CG   CD1  CD2                                       
REMARK 470     TYR M 334    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP M 335    CG   OD1  OD2                                       
REMARK 470     TYR M 336    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP M 338    CG   OD1  OD2                                       
REMARK 470     ARG M 339    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER M 340    OG                                                  
REMARK 470     LYS M 341    CG   CD   CE   NZ                                   
REMARK 470     SER M 343    OG                                                  
REMARK 470     ILE M 344    CG1  CG2  CD1                                       
REMARK 470     GLU M 345    CG   CD   OE1  OE2                                  
REMARK 470     PHE M 347    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO M 348    CG   CD                                             
REMARK 470     TRP M 349    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP M 349    CZ3  CH2                                            
REMARK 470     LEU M 350    CG   CD1  CD2                                       
REMARK 470     LYS M 351    CG   CD   CE   NZ                                   
REMARK 470     HIS M 352    CG   ND1  CD2  CE1  NE2                             
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    GLY H 101   N   -  CA  -  C   ANGL. DEV. =  16.0 DEGREES          
REMARK 500    PRO M 266   C   -  N   -  CA  ANGL. DEV. =  11.4 DEGREES          
REMARK 500    PRO M 348   C   -  N   -  CA  ANGL. DEV. =   9.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU A  60      109.80    -48.51                                   
REMARK 500    ARG A  63      134.30    -36.19                                   
REMARK 500    PHE A  78      -75.56    -78.14                                   
REMARK 500    ASP A  81       71.66     64.81                                   
REMARK 500    SER A  87      -72.99    -49.92                                   
REMARK 500    GLU A 105      -71.16    -50.99                                   
REMARK 500    ARG A 134      -66.39   -104.82                                   
REMARK 500    ASN B  25      -61.69     71.56                                   
REMARK 500    ILE B  29       87.09    -64.17                                   
REMARK 500    ALA B  33      -50.56   -127.85                                   
REMARK 500    PHE G  25      103.60    -59.30                                   
REMARK 500    PRO G  26      101.23    -31.64                                   
REMARK 500    VAL G  49      -70.34    -54.95                                   
REMARK 500    LYS G  75      -73.00    -90.44                                   
REMARK 500    THR G  76      -57.51   -123.79                                   
REMARK 500    ASN G  94      -37.95    -38.20                                   
REMARK 500    LEU G  97       51.03    -99.06                                   
REMARK 500    LEU G 108      109.82    -58.54                                   
REMARK 500    VAL G 114       30.41    -87.05                                   
REMARK 500    THR H  49      -90.63   -112.12                                   
REMARK 500    LYS H  82       63.74     35.77                                   
REMARK 500    SER H  84       47.95    -80.63                                   
REMARK 500    THR H  85      123.22   -172.55                                   
REMARK 500    HIS K  28      -49.51   -168.20                                   
REMARK 500    MET K  39       40.21   -106.50                                   
REMARK 500    TYR K  40      -76.10   -154.92                                   
REMARK 500    VAL K  43      -66.86    -96.36                                   
REMARK 500    MET K  56       34.61    -91.88                                   
REMARK 500    VAL K  70      103.60   -166.69                                   
REMARK 500    ARG K  74     -167.65   -164.18                                   
REMARK 500    LEU K  79       79.77   -119.69                                   
REMARK 500    MET K  94       53.13   -117.16                                   
REMARK 500    HIS K  95      112.19   -166.22                                   
REMARK 500    SER K 103     -164.95   -102.57                                   
REMARK 500    ARG K 118     -174.30   -174.45                                   
REMARK 500    PRO K 150      108.55    -49.98                                   
REMARK 500    GLU K 163       39.90   -161.18                                   
REMARK 500    ASN K 175       30.35   -147.95                                   
REMARK 500    LEU K 180       94.11    -69.70                                   
REMARK 500    GLN K 203     -119.43     60.90                                   
REMARK 500    GLN K 209       71.98   -106.28                                   
REMARK 500    SER K 219      119.37     81.16                                   
REMARK 500    VAL K 224      -70.74    -71.88                                   
REMARK 500    ALA K 227       92.43   -161.87                                   
REMARK 500    LYS K 230     -152.94     67.05                                   
REMARK 500    HIS K 232       65.46   -119.56                                   
REMARK 500    VAL K 242       96.36    -61.27                                   
REMARK 500    ALA K 244      118.94   -168.44                                   
REMARK 500    ASN K 247      -72.21    -95.19                                   
REMARK 500    ARG K 258     -174.57   -173.00                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      92 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  5HQ2 A    1   135  UNP    P84233   H32_XENLA        2    136             
DBREF  5HQ2 B    1   102  UNP    P62799   H4_XENLA         2    103             
DBREF  5HQ2 G    1   129  UNP    Q6AZJ8   Q6AZJ8_XENLA     2    130             
DBREF  5HQ2 H    1   122  UNP    P02281   H2B11_XENLA      5    126             
DBREF  5HQ2 I  -74    74  PDB    5HQ2     5HQ2           -74     74             
DBREF  5HQ2 J  -74    74  PDB    5HQ2     5HQ2           -74     74             
DBREF  5HQ2 K    2   480  UNP    P21827   RCC1_YEAST       2    482             
DBREF  5HQ2 M  153   352  UNP    Q9NQR1   SETD8_HUMAN    153    352             
SEQADV 5HQ2 ALA A  102  UNP  P84233    GLY   103 CONFLICT                       
SEQADV 5HQ2 THR H   29  UNP  P02281    SER    33 CONFLICT                       
SEQADV 5HQ2 GLY K    0  UNP  P21827              EXPRESSION TAG                 
SEQADV 5HQ2 SER K    1  UNP  P21827              EXPRESSION TAG                 
SEQADV 5HQ2 GLY M  151  UNP  Q9NQR1              EXPRESSION TAG                 
SEQADV 5HQ2 SER M  152  UNP  Q9NQR1              EXPRESSION TAG                 
SEQADV 5HQ2 PHE M  347  UNP  Q9NQR1    HIS   347 CONFLICT                       
SEQRES   1 A  135  ALA ARG THR LYS GLN THR ALA ARG LYS SER THR GLY GLY          
SEQRES   2 A  135  LYS ALA PRO ARG LYS GLN LEU ALA THR LYS ALA ALA ARG          
SEQRES   3 A  135  LYS SER ALA PRO ALA THR GLY GLY VAL LYS LYS PRO HIS          
SEQRES   4 A  135  ARG TYR ARG PRO GLY THR VAL ALA LEU ARG GLU ILE ARG          
SEQRES   5 A  135  ARG TYR GLN LYS SER THR GLU LEU LEU ILE ARG LYS LEU          
SEQRES   6 A  135  PRO PHE GLN ARG LEU VAL ARG GLU ILE ALA GLN ASP PHE          
SEQRES   7 A  135  LYS THR ASP LEU ARG PHE GLN SER SER ALA VAL MET ALA          
SEQRES   8 A  135  LEU GLN GLU ALA SER GLU ALA TYR LEU VAL ALA LEU PHE          
SEQRES   9 A  135  GLU ASP THR ASN LEU CYS ALA ILE HIS ALA LYS ARG VAL          
SEQRES  10 A  135  THR ILE MET PRO LYS ASP ILE GLN LEU ALA ARG ARG ILE          
SEQRES  11 A  135  ARG GLY GLU ARG ALA                                          
SEQRES   1 B  102  SER GLY ARG GLY LYS GLY GLY LYS GLY LEU GLY LYS GLY          
SEQRES   2 B  102  GLY ALA LYS ARG HIS ARG LYS VAL LEU ARG ASP ASN ILE          
SEQRES   3 B  102  GLN GLY ILE THR LYS PRO ALA ILE ARG ARG LEU ALA ARG          
SEQRES   4 B  102  ARG GLY GLY VAL LYS ARG ILE SER GLY LEU ILE TYR GLU          
SEQRES   5 B  102  GLU THR ARG GLY VAL LEU LYS VAL PHE LEU GLU ASN VAL          
SEQRES   6 B  102  ILE ARG ASP ALA VAL THR TYR THR GLU HIS ALA LYS ARG          
SEQRES   7 B  102  LYS THR VAL THR ALA MET ASP VAL VAL TYR ALA LEU LYS          
SEQRES   8 B  102  ARG GLN GLY ARG THR LEU TYR GLY PHE GLY GLY                  
SEQRES   1 G  129  SER GLY ARG GLY LYS GLN GLY GLY LYS THR ARG ALA LYS          
SEQRES   2 G  129  ALA LYS THR ARG SER SER ARG ALA GLY LEU GLN PHE PRO          
SEQRES   3 G  129  VAL GLY ARG VAL HIS ARG LEU LEU ARG LYS GLY ASN TYR          
SEQRES   4 G  129  ALA GLU ARG VAL GLY ALA GLY ALA PRO VAL TYR LEU ALA          
SEQRES   5 G  129  ALA VAL LEU GLU TYR LEU THR ALA GLU ILE LEU GLU LEU          
SEQRES   6 G  129  ALA GLY ASN ALA ALA ARG ASP ASN LYS LYS THR ARG ILE          
SEQRES   7 G  129  ILE PRO ARG HIS LEU GLN LEU ALA VAL ARG ASN ASP GLU          
SEQRES   8 G  129  GLU LEU ASN LYS LEU LEU GLY ARG VAL THR ILE ALA GLN          
SEQRES   9 G  129  GLY GLY VAL LEU PRO ASN ILE GLN SER VAL LEU LEU PRO          
SEQRES  10 G  129  LYS LYS THR GLU SER SER LYS SER ALA LYS SER LYS              
SEQRES   1 H  122  ALA LYS SER ALA PRO ALA PRO LYS LYS GLY SER LYS LYS          
SEQRES   2 H  122  ALA VAL THR LYS THR GLN LYS LYS ASP GLY LYS LYS ARG          
SEQRES   3 H  122  ARG LYS THR ARG LYS GLU SER TYR ALA ILE TYR VAL TYR          
SEQRES   4 H  122  LYS VAL LEU LYS GLN VAL HIS PRO ASP THR GLY ILE SER          
SEQRES   5 H  122  SER LYS ALA MET SER ILE MET ASN SER PHE VAL ASN ASP          
SEQRES   6 H  122  VAL PHE GLU ARG ILE ALA GLY GLU ALA SER ARG LEU ALA          
SEQRES   7 H  122  HIS TYR ASN LYS ARG SER THR ILE THR SER ARG GLU ILE          
SEQRES   8 H  122  GLN THR ALA VAL ARG LEU LEU LEU PRO GLY GLU LEU ALA          
SEQRES   9 H  122  LYS HIS ALA VAL SER GLU GLY THR LYS ALA VAL THR LYS          
SEQRES  10 H  122  TYR THR SER ALA LYS                                          
SEQRES   1 I  149   DA  DT  DC  DG  DG  DA  DG  DA  DA  DT  DC  DC  DC          
SEQRES   2 I  149   DG  DG  DT  DG  DC  DC  DG  DA  DG  DG  DC  DC  DG          
SEQRES   3 I  149   DC  DT  DC  DA  DA  DT  DT  DG  DG  DT  DC  DG  DT          
SEQRES   4 I  149   DA  DG  DA  DC  DA  DG  DC  DT  DC  DT  DA  DG  DC          
SEQRES   5 I  149   DA  DC  DC  DG  DC  DT  DT  DA  DA  DA  DC  DG  DC          
SEQRES   6 I  149   DA  DC  DG  DT  DA  DC  DG  DC  DG  DC  DT  DG  DT          
SEQRES   7 I  149   DC  DC  DC  DC  DC  DG  DC  DG  DT  DT  DT  DT  DA          
SEQRES   8 I  149   DA  DC  DC  DG  DC  DC  DA  DA  DG  DG  DG  DG  DA          
SEQRES   9 I  149   DT  DT  DA  DC  DT  DC  DC  DC  DT  DA  DG  DT  DC          
SEQRES  10 I  149   DT  DC  DC  DA  DG  DG  DC  DA  DC  DG  DT  DG  DT          
SEQRES  11 I  149   DC  DA  DG  DA  DT  DA  DT  DA  DT  DA  DC  DA  DT          
SEQRES  12 I  149   DC  DC  DT  DG  DA  DT                                      
SEQRES   1 J  149   DA  DT  DC  DA  DG  DG  DA  DT  DG  DT  DA  DT  DA          
SEQRES   2 J  149   DT  DA  DT  DC  DT  DG  DA  DC  DA  DC  DG  DT  DG          
SEQRES   3 J  149   DC  DC  DT  DG  DG  DA  DG  DA  DC  DT  DA  DG  DG          
SEQRES   4 J  149   DG  DA  DG  DT  DA  DA  DT  DC  DC  DC  DC  DT  DT          
SEQRES   5 J  149   DG  DG  DC  DG  DG  DT  DT  DA  DA  DA  DA  DC  DG          
SEQRES   6 J  149   DC  DG  DG  DG  DG  DG  DA  DC  DA  DG  DC  DG  DC          
SEQRES   7 J  149   DG  DT  DA  DC  DG  DT  DG  DC  DG  DT  DT  DT  DA          
SEQRES   8 J  149   DA  DG  DC  DG  DG  DT  DG  DC  DT  DA  DG  DA  DG          
SEQRES   9 J  149   DC  DT  DG  DT  DC  DT  DA  DC  DG  DA  DC  DC  DA          
SEQRES  10 J  149   DA  DT  DT  DG  DA  DG  DC  DG  DG  DC  DC  DT  DC          
SEQRES  11 J  149   DG  DG  DC  DA  DC  DC  DG  DG  DG  DA  DT  DT  DC          
SEQRES  12 J  149   DT  DC  DC  DG  DA  DT                                      
SEQRES   1 K  483  GLY SER VAL LYS ARG THR VAL ALA THR ASN GLY ASP ALA          
SEQRES   2 K  483  SER GLY ALA HIS ARG ALA LYS LYS MET SER LYS THR HIS          
SEQRES   3 K  483  ALA SER HIS ILE ILE ASN ALA GLN GLU ASP TYR LYS HIS          
SEQRES   4 K  483  MET TYR LEU SER VAL GLN PRO LEU ASP ILE PHE CYS TRP          
SEQRES   5 K  483  GLY THR GLY SER MET CYS GLU LEU GLY LEU GLY PRO LEU          
SEQRES   6 K  483  ALA LYS ASN LYS GLU VAL LYS ARG PRO ARG LEU ASN PRO          
SEQRES   7 K  483  PHE LEU PRO ARG ASP GLU ALA LYS ILE ILE SER PHE ALA          
SEQRES   8 K  483  VAL GLY GLY MET HIS THR LEU ALA LEU ASP GLU GLU SER          
SEQRES   9 K  483  ASN VAL TRP SER TRP GLY CYS ASN ASP VAL GLY ALA LEU          
SEQRES  10 K  483  GLY ARG ASP THR SER ASN ALA LYS GLU GLN LEU LYS ASP          
SEQRES  11 K  483  MET ASP ALA ASP ASP SER SER ASP ASP GLU ASP GLY ASP          
SEQRES  12 K  483  LEU ASN GLU LEU GLU SER THR PRO ALA LYS ILE PRO ARG          
SEQRES  13 K  483  GLU SER PHE PRO PRO LEU ALA GLU GLY HIS LYS VAL VAL          
SEQRES  14 K  483  GLN LEU ALA ALA THR ASP ASN MET SER CYS ALA LEU PHE          
SEQRES  15 K  483  SER ASN GLY GLU VAL TYR ALA TRP GLY THR PHE ARG CYS          
SEQRES  16 K  483  ASN GLU GLY ILE LEU GLY PHE TYR GLN ASP LYS ILE LYS          
SEQRES  17 K  483  ILE GLN LYS THR PRO TRP LYS VAL PRO THR PHE SER LYS          
SEQRES  18 K  483  TYR ASN ILE VAL GLN LEU ALA PRO GLY LYS ASP HIS ILE          
SEQRES  19 K  483  LEU PHE LEU ASP GLU GLU GLY MET VAL PHE ALA TRP GLY          
SEQRES  20 K  483  ASN GLY GLN GLN ASN GLN LEU GLY ARG LYS VAL MET GLU          
SEQRES  21 K  483  ARG PHE ARG LEU LYS THR LEU ASP PRO ARG PRO PHE GLY          
SEQRES  22 K  483  LEU ARG HIS VAL LYS TYR ILE ALA SER GLY GLU ASN HIS          
SEQRES  23 K  483  CYS PHE ALA LEU THR LYS ASP ASN LYS LEU VAL SER TRP          
SEQRES  24 K  483  GLY LEU ASN GLN PHE GLY GLN CYS GLY VAL SER GLU ASP          
SEQRES  25 K  483  VAL GLU ASP GLY ALA LEU VAL THR LYS PRO LYS ARG LEU          
SEQRES  26 K  483  ALA LEU PRO ASP ASN VAL VAL ILE ARG SER ILE ALA ALA          
SEQRES  27 K  483  GLY GLU HIS HIS SER LEU ILE LEU SER GLN ASP GLY ASP          
SEQRES  28 K  483  LEU TYR SER CYS GLY ARG LEU ASP MET PHE GLU VAL GLY          
SEQRES  29 K  483  ILE PRO LYS ASP ASN LEU PRO GLU TYR THR TYR LYS ASP          
SEQRES  30 K  483  VAL HIS GLY LYS ALA ARG ALA VAL PRO LEU PRO THR LYS          
SEQRES  31 K  483  LEU ASN ASN VAL PRO LYS PHE LYS SER VAL ALA ALA GLY          
SEQRES  32 K  483  SER HIS HIS SER VAL ALA VAL ALA GLN ASN GLY ILE ALA          
SEQRES  33 K  483  TYR SER TRP GLY PHE GLY GLU THR TYR ALA VAL GLY LEU          
SEQRES  34 K  483  GLY PRO PHE GLU ASP ASP THR GLU VAL PRO THR ARG ILE          
SEQRES  35 K  483  LYS ASN THR ALA THR GLN ASP HIS ASN ILE ILE LEU VAL          
SEQRES  36 K  483  GLY CYS GLY GLY GLN PHE SER VAL SER GLY GLY VAL LYS          
SEQRES  37 K  483  LEU SER ASP GLU ASP ALA GLU LYS ARG ALA ASP GLU MET          
SEQRES  38 K  483  ASP ASP                                                      
SEQRES   1 M  202  GLY SER ALA LYS GLN ALA LEU LYS LYS PRO ILE LYS GLY          
SEQRES   2 M  202  LYS GLN ALA PRO ARG LYS LYS ALA GLN GLY LYS THR GLN          
SEQRES   3 M  202  GLN ASN ARG LYS LEU THR ASP PHE TYR PRO VAL ARG ARG          
SEQRES   4 M  202  SER SER ARG LYS SER LYS ALA GLU LEU GLN SER GLU GLU          
SEQRES   5 M  202  ARG LYS ARG ILE ASP GLU LEU ILE GLU SER GLY LYS GLU          
SEQRES   6 M  202  GLU GLY MET LYS ILE ASP LEU ILE ASP GLY LYS GLY ARG          
SEQRES   7 M  202  GLY VAL ILE ALA THR LYS GLN PHE SER ARG GLY ASP PHE          
SEQRES   8 M  202  VAL VAL GLU TYR HIS GLY ASP LEU ILE GLU ILE THR ASP          
SEQRES   9 M  202  ALA LYS LYS ARG GLU ALA LEU TYR ALA GLN ASP PRO SER          
SEQRES  10 M  202  THR GLY CYS TYR MET TYR TYR PHE GLN TYR LEU SER LYS          
SEQRES  11 M  202  THR TYR CYS VAL ASP ALA THR ARG GLU THR ASN ARG LEU          
SEQRES  12 M  202  GLY ARG LEU ILE ASN HIS SER LYS CYS GLY ASN CYS GLN          
SEQRES  13 M  202  THR LYS LEU HIS ASP ILE ASP GLY VAL PRO HIS LEU ILE          
SEQRES  14 M  202  LEU ILE ALA SER ARG ASP ILE ALA ALA GLY GLU GLU LEU          
SEQRES  15 M  202  LEU TYR ASP TYR GLY ASP ARG SER LYS ALA SER ILE GLU          
SEQRES  16 M  202  ALA PHE PRO TRP LEU LYS HIS                                  
HELIX    1 AA1 GLY A   44  GLN A   55  1                                  12    
HELIX    2 AA2 ARG A   63  LYS A   79  1                                  17    
HELIX    3 AA3 GLN A   85  HIS A  113  1                                  29    
HELIX    4 AA4 MET A  120  GLY A  132  1                                  13    
HELIX    5 AA5 THR B   30  ARG B   40  1                                  11    
HELIX    6 AA6 LEU B   49  HIS B   75  1                                  27    
HELIX    7 AA7 THR B   82  GLY B   94  1                                  13    
HELIX    8 AA8 THR G   16  GLY G   22  1                                   7    
HELIX    9 AA9 GLY G   28  GLY G   37  1                                  10    
HELIX   10 AB1 ALA G   45  LYS G   74  1                                  30    
HELIX   11 AB2 ILE G   79  ARG G   88  1                                  10    
HELIX   12 AB3 ASP G   90  LEU G   97  1                                   8    
HELIX   13 AB4 TYR H   34  HIS H   46  1                                  13    
HELIX   14 AB5 LYS H   54  MET H   59  1                                   6    
HELIX   15 AB6 MET H   59  TYR H   80  1                                  22    
HELIX   16 AB7 THR H   87  LEU H   99  1                                  13    
HELIX   17 AB8 PRO H  100  SER H  120  1                                  21    
HELIX   18 AB9 GLN K   33  LYS K   37  5                                   5    
HELIX   19 AC1 PRO K   80  LYS K   85  1                                   6    
HELIX   20 AC2 GLU K  145  THR K  149  5                                   5    
HELIX   21 AC3 SER K  467  ALA K  475  1                                   9    
HELIX   22 AC4 SER M  194  GLY M  213  1                                  20    
HELIX   23 AC5 LYS M  257  ALA M  263  1                                   7    
HELIX   24 AC6 LEU M  293  ILE M  297  5                                   5    
HELIX   25 AC7 SER M  340  PHE M  347  1                                   8    
HELIX   26 AC8 PRO M  348  LYS M  351  5                                   4    
SHEET    1 AA1 2 ARG A  83  PHE A  84  0                                        
SHEET    2 AA1 2 THR B  80  VAL B  81  1  O  VAL B  81   N  ARG A  83           
SHEET    1 AA2 2 LEU B  97  TYR B  98  0                                        
SHEET    2 AA2 2 THR G 101  ILE G 102  1  O  THR G 101   N  TYR B  98           
SHEET    1 AA3 3 ASP K  47  ILE K  48  0                                        
SHEET    2 AA3 3 GLY K 462  VAL K 464 -1  O  GLY K 463   N  ASP K  47           
SHEET    3 AA3 3 ASN K 448  ILE K 449 -1  N  ASN K 448   O  VAL K 464           
SHEET    1 AA4 4 SER K  88  ALA K  90  0                                        
SHEET    2 AA4 4 THR K  96  LEU K  99 -1  O  LEU K  99   N  SER K  88           
SHEET    3 AA4 4 TRP K 106  TRP K 108 -1  O  TRP K 106   N  ALA K  98           
SHEET    4 AA4 4 ALA K 151  LYS K 152 -1  O  ALA K 151   N  SER K 107           
SHEET    1 AA5 3 MET K 176  SER K 177  0                                        
SHEET    2 AA5 3 VAL K 186  GLY K 190 -1  O  TRP K 189   N  SER K 177           
SHEET    3 AA5 3 GLN K 209  VAL K 215 -1  O  VAL K 215   N  VAL K 186           
SHEET    1 AA6 2 PHE K 192  ARG K 193  0                                        
SHEET    2 AA6 2 LEU K 199  GLY K 200 -1  O  GLY K 200   N  PHE K 192           
SHEET    1 AA7 2 VAL K 274  ILE K 277  0                                        
SHEET    2 AA7 2 ALA K 286  THR K 288 -1  O  LEU K 287   N  LYS K 275           
SHEET    1 AA8 5 ILE K 330  ALA K 335  0                                        
SHEET    2 AA8 5 HIS K 339  SER K 344 -1  O  LEU K 341   N  ALA K 334           
SHEET    3 AA8 5 LEU K 349  ARG K 354 -1  O  CYS K 352   N  SER K 340           
SHEET    4 AA8 5 ALA K 379  VAL K 382 -1  O  VAL K 382   N  GLY K 353           
SHEET    5 AA8 5 TYR K 372  LYS K 373 -1  N  TYR K 372   O  ALA K 381           
SHEET    1 AA9 4 PHE K 394  VAL K 397  0                                        
SHEET    2 AA9 4 HIS K 403  ALA K 408 -1  O  VAL K 407   N  LYS K 395           
SHEET    3 AA9 4 ALA K 413  GLY K 417 -1  O  TRP K 416   N  SER K 404           
SHEET    4 AA9 4 ARG K 438  ILE K 439 -1  O  ILE K 439   N  ALA K 413           
SHEET    1 AB1 4 LYS M 219  LEU M 222  0                                        
SHEET    2 AB1 4 ARG M 228  ILE M 231 -1  O  GLY M 229   N  ASP M 221           
SHEET    3 AB1 4 GLU M 331  TYR M 334 -1  O  LEU M 332   N  VAL M 230           
SHEET    4 AB1 4 ASN M 298  HIS M 299  1  N  ASN M 298   O  TYR M 334           
SHEET    1 AB2 3 PHE M 241  GLU M 244  0                                        
SHEET    2 AB2 3 LEU M 318  ILE M 321 -1  O  LEU M 320   N  VAL M 242           
SHEET    3 AB2 3 GLN M 306  LEU M 309 -1  N  GLN M 306   O  ILE M 321           
CISPEP   1 ASP H   48    THR H   49          0        -6.49                     
CISPEP   2 THR H   49    GLY H   50          0        -6.98                     
CISPEP   3 GLU K  102    SER K  103          0         0.72                     
CISPEP   4 PRO K  266    ARG K  267          0         4.40                     
CISPEP   5 PRO K  268    PHE K  269          0        14.24                     
CRYST1  100.729  300.752  182.090  90.00  90.00  90.00 C 2 2 21      8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.009928  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.003325  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.005492        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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