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Database: PDB
Entry: 5L4K
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Original site: 5L4K 
HEADER    STRUCTURAL PROTEIN                      25-MAY-16   5L4K              
TITLE     THE HUMAN 26S PROTEASOME LID                                          
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4;            
COMPND   3 CHAIN: W;                                                            
COMPND   4 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN10,26S PROTEASOME      
COMPND   5 REGULATORY SUBUNIT S5A,ANTISECRETORY FACTOR 1,ASF,MULTIUBIQUITIN     
COMPND   6 CHAIN-BINDING PROTEIN;                                               
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14;           
COMPND   9 CHAIN: V;                                                            
COMPND  10 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN11,26S PROTEASOME-     
COMPND  11 ASSOCIATED PAD1 HOMOLOG 1;                                           
COMPND  12 EC: 3.4.19.-;                                                        
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8;            
COMPND  15 CHAIN: T;                                                            
COMPND  16 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN12,26S PROTEASOME      
COMPND  17 REGULATORY SUBUNIT S14,P31;                                          
COMPND  18 MOL_ID: 4;                                                           
COMPND  19 MOLECULE: 26S PROTEASOME COMPLEX SUBUNIT DSS1;                       
COMPND  20 CHAIN: Y;                                                            
COMPND  21 SYNONYM: DELETED IN SPLIT HAND/SPLIT FOOT PROTEIN 1,SPLIT HAND/FOOT  
COMPND  22 DELETED PROTEIN 1,SPLIT HAND/FOOT MALFORMATION TYPE 1 PROTEIN;       
COMPND  23 MOL_ID: 5;                                                           
COMPND  24 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2;            
COMPND  25 CHAIN: Z;                                                            
COMPND  26 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN1,26S PROTEASOME       
COMPND  27 REGULATORY SUBUNIT S2,26S PROTEASOME SUBUNIT P97,PROTEIN 55.11,TUMOR 
COMPND  28 NECROSIS FACTOR TYPE 1 RECEPTOR-ASSOCIATED PROTEIN 2;                
COMPND  29 MOL_ID: 6;                                                           
COMPND  30 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1;            
COMPND  31 CHAIN: N;                                                            
COMPND  32 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN2,26S PROTEASOME       
COMPND  33 REGULATORY SUBUNIT S1,26S PROTEASOME SUBUNIT P112;                   
COMPND  34 MOL_ID: 7;                                                           
COMPND  35 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3;            
COMPND  36 CHAIN: S;                                                            
COMPND  37 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN3,26S PROTEASOME       
COMPND  38 REGULATORY SUBUNIT S3,PROTEASOME SUBUNIT P58;                        
COMPND  39 MOL_ID: 8;                                                           
COMPND  40 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12;           
COMPND  41 CHAIN: P;                                                            
COMPND  42 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN5,26S PROTEASOME       
COMPND  43 REGULATORY SUBUNIT P55;                                              
COMPND  44 MOL_ID: 9;                                                           
COMPND  45 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11;           
COMPND  46 CHAIN: Q;                                                            
COMPND  47 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN6,26S PROTEASOME       
COMPND  48 REGULATORY SUBUNIT S9,26S PROTEASOME REGULATORY SUBUNIT P44.5;       
COMPND  49 MOL_ID: 10;                                                          
COMPND  50 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6;            
COMPND  51 CHAIN: R;                                                            
COMPND  52 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN7,26S PROTEASOME       
COMPND  53 REGULATORY SUBUNIT S10,BREAST CANCER-ASSOCIATED PROTEIN SGA-113M,    
COMPND  54 PHOSPHONOFORMATE IMMUNO-ASSOCIATED PROTEIN 4,PROTEASOME REGULATORY   
COMPND  55 PARTICLE SUBUNIT P44S10,P42A;                                        
COMPND  56 MOL_ID: 11;                                                          
COMPND  57 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7;            
COMPND  58 CHAIN: U;                                                            
COMPND  59 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN8,26S PROTEASOME       
COMPND  60 REGULATORY SUBUNIT S12,MOV34 PROTEIN HOMOLOG,PROTEASOME SUBUNIT P40; 
COMPND  61 MOL_ID: 12;                                                          
COMPND  62 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13;           
COMPND  63 CHAIN: O;                                                            
COMPND  64 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN9,26S PROTEASOME       
COMPND  65 REGULATORY SUBUNIT S11,26S PROTEASOME REGULATORY SUBUNIT P40.5       
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   7 ORGANISM_COMMON: HUMAN;                                              
SOURCE   8 ORGANISM_TAXID: 9606;                                                
SOURCE   9 MOL_ID: 3;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 MOL_ID: 4;                                                           
SOURCE  14 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  15 ORGANISM_COMMON: HUMAN;                                              
SOURCE  16 ORGANISM_TAXID: 9606;                                                
SOURCE  17 MOL_ID: 5;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 MOL_ID: 6;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  23 ORGANISM_COMMON: HUMAN;                                              
SOURCE  24 ORGANISM_TAXID: 9606;                                                
SOURCE  25 MOL_ID: 7;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 MOL_ID: 8;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  31 ORGANISM_COMMON: HUMAN;                                              
SOURCE  32 ORGANISM_TAXID: 9606;                                                
SOURCE  33 MOL_ID: 9;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  35 ORGANISM_COMMON: HUMAN;                                              
SOURCE  36 ORGANISM_TAXID: 9606;                                                
SOURCE  37 MOL_ID: 10;                                                          
SOURCE  38 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  39 ORGANISM_COMMON: HUMAN;                                              
SOURCE  40 ORGANISM_TAXID: 9606;                                                
SOURCE  41 MOL_ID: 11;                                                          
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 MOL_ID: 12;                                                          
SOURCE  46 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  47 ORGANISM_COMMON: HUMAN;                                              
SOURCE  48 ORGANISM_TAXID: 9606                                                 
KEYWDS    PROTEOSTASIS, AAA-ATPASE, STRUCTURAL PROTEIN                          
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    A.SCHWEITZER,A.AUFDERHEIDE,T.RUDACK,F.BECK                            
REVDAT   4   02-AUG-17 5L4K    1                                                
REVDAT   3   05-OCT-16 5L4K    1                                                
REVDAT   2   21-SEP-16 5L4K    1       JRNL                                     
REVDAT   1   07-SEP-16 5L4K    0                                                
JRNL        AUTH   A.SCHWEITZER,A.AUFDERHEIDE,T.RUDACK,F.BECK,G.PFEIFER,        
JRNL        AUTH 2 J.M.PLITZKO,E.SAKATA,K.SCHULTEN,F.FORSTER,W.BAUMEISTER       
JRNL        TITL   STRUCTURE OF THE HUMAN 26S PROTEASOME AT A RESOLUTION OF 3.9 
JRNL        TITL 2 ANGSTROM.                                                    
JRNL        REF    PROC.NATL.ACAD.SCI.USA        V. 113  7816 2016              
JRNL        REFN                   ESSN 1091-6490                               
JRNL        PMID   27342858                                                     
JRNL        DOI    10.1073/PNAS.1608050113                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.50 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : TOM TOOLBOX, CTFFIND, MDFF, RELION,       
REMARK   3                            PHENIX                                    
REMARK   3   RECONSTRUCTION SCHEMA  : FOURIER SPACE                             
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.900                          
REMARK   3   NUMBER OF PARTICLES               : 461402                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5L4K COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 25-MAY-16.                  
REMARK 100 THE DEPOSITION ID IS D_1200000109.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : HUMAN 26S PROTEASOME LID          
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 40211                          
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : OTHER                          
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 45.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC                
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 49450 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 220080 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -290.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: W, V, T, Y, Z, N, S, P, Q, R,         
REMARK 350                    AND CHAINS: U, O                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     LEU W   197                                                      
REMARK 465     GLY W   198                                                      
REMARK 465     LEU W   199                                                      
REMARK 465     GLY W   200                                                      
REMARK 465     ALA W   201                                                      
REMARK 465     SER W   202                                                      
REMARK 465     ASP W   203                                                      
REMARK 465     PHE W   204                                                      
REMARK 465     GLU W   205                                                      
REMARK 465     PHE W   206                                                      
REMARK 465     GLY W   207                                                      
REMARK 465     VAL W   208                                                      
REMARK 465     ASP W   209                                                      
REMARK 465     PRO W   210                                                      
REMARK 465     SER W   211                                                      
REMARK 465     ALA W   212                                                      
REMARK 465     ASP W   213                                                      
REMARK 465     PRO W   214                                                      
REMARK 465     GLU W   215                                                      
REMARK 465     LEU W   216                                                      
REMARK 465     ALA W   217                                                      
REMARK 465     LEU W   218                                                      
REMARK 465     ALA W   219                                                      
REMARK 465     LEU W   220                                                      
REMARK 465     ARG W   221                                                      
REMARK 465     VAL W   222                                                      
REMARK 465     SER W   223                                                      
REMARK 465     MET W   224                                                      
REMARK 465     GLU W   225                                                      
REMARK 465     GLU W   226                                                      
REMARK 465     GLN W   227                                                      
REMARK 465     ARG W   228                                                      
REMARK 465     GLN W   229                                                      
REMARK 465     ARG W   230                                                      
REMARK 465     GLN W   231                                                      
REMARK 465     GLU W   232                                                      
REMARK 465     GLU W   233                                                      
REMARK 465     GLU W   234                                                      
REMARK 465     ALA W   235                                                      
REMARK 465     ARG W   236                                                      
REMARK 465     ARG W   237                                                      
REMARK 465     ALA W   238                                                      
REMARK 465     ALA W   239                                                      
REMARK 465     ALA W   240                                                      
REMARK 465     ALA W   241                                                      
REMARK 465     SER W   242                                                      
REMARK 465     ALA W   243                                                      
REMARK 465     ALA W   244                                                      
REMARK 465     GLU W   245                                                      
REMARK 465     ALA W   246                                                      
REMARK 465     GLY W   247                                                      
REMARK 465     ILE W   248                                                      
REMARK 465     ALA W   249                                                      
REMARK 465     THR W   250                                                      
REMARK 465     THR W   251                                                      
REMARK 465     GLY W   252                                                      
REMARK 465     THR W   253                                                      
REMARK 465     GLU W   254                                                      
REMARK 465     ASP W   255                                                      
REMARK 465     SER W   256                                                      
REMARK 465     ASP W   257                                                      
REMARK 465     ASP W   258                                                      
REMARK 465     ALA W   259                                                      
REMARK 465     LEU W   260                                                      
REMARK 465     LEU W   261                                                      
REMARK 465     LYS W   262                                                      
REMARK 465     MET W   263                                                      
REMARK 465     THR W   264                                                      
REMARK 465     ILE W   265                                                      
REMARK 465     SER W   266                                                      
REMARK 465     GLN W   267                                                      
REMARK 465     GLN W   268                                                      
REMARK 465     GLU W   269                                                      
REMARK 465     PHE W   270                                                      
REMARK 465     GLY W   271                                                      
REMARK 465     ARG W   272                                                      
REMARK 465     THR W   273                                                      
REMARK 465     GLY W   274                                                      
REMARK 465     LEU W   275                                                      
REMARK 465     PRO W   276                                                      
REMARK 465     ASP W   277                                                      
REMARK 465     LEU W   278                                                      
REMARK 465     SER W   279                                                      
REMARK 465     SER W   280                                                      
REMARK 465     MET W   281                                                      
REMARK 465     THR W   282                                                      
REMARK 465     GLU W   283                                                      
REMARK 465     GLU W   284                                                      
REMARK 465     GLU W   285                                                      
REMARK 465     GLN W   286                                                      
REMARK 465     ILE W   287                                                      
REMARK 465     ALA W   288                                                      
REMARK 465     TYR W   289                                                      
REMARK 465     ALA W   290                                                      
REMARK 465     MET W   291                                                      
REMARK 465     GLN W   292                                                      
REMARK 465     MET W   293                                                      
REMARK 465     SER W   294                                                      
REMARK 465     LEU W   295                                                      
REMARK 465     GLN W   296                                                      
REMARK 465     GLY W   297                                                      
REMARK 465     ALA W   298                                                      
REMARK 465     GLU W   299                                                      
REMARK 465     PHE W   300                                                      
REMARK 465     GLY W   301                                                      
REMARK 465     GLN W   302                                                      
REMARK 465     ALA W   303                                                      
REMARK 465     GLU W   304                                                      
REMARK 465     SER W   305                                                      
REMARK 465     ALA W   306                                                      
REMARK 465     ASP W   307                                                      
REMARK 465     ILE W   308                                                      
REMARK 465     ASP W   309                                                      
REMARK 465     ALA W   310                                                      
REMARK 465     SER W   311                                                      
REMARK 465     SER W   312                                                      
REMARK 465     ALA W   313                                                      
REMARK 465     MET W   314                                                      
REMARK 465     ASP W   315                                                      
REMARK 465     THR W   316                                                      
REMARK 465     SER W   317                                                      
REMARK 465     GLU W   318                                                      
REMARK 465     PRO W   319                                                      
REMARK 465     ALA W   320                                                      
REMARK 465     LYS W   321                                                      
REMARK 465     GLU W   322                                                      
REMARK 465     GLU W   323                                                      
REMARK 465     ASP W   324                                                      
REMARK 465     ASP W   325                                                      
REMARK 465     TYR W   326                                                      
REMARK 465     ASP W   327                                                      
REMARK 465     VAL W   328                                                      
REMARK 465     MET W   329                                                      
REMARK 465     GLN W   330                                                      
REMARK 465     ASP W   331                                                      
REMARK 465     PRO W   332                                                      
REMARK 465     GLU W   333                                                      
REMARK 465     PHE W   334                                                      
REMARK 465     LEU W   335                                                      
REMARK 465     GLN W   336                                                      
REMARK 465     SER W   337                                                      
REMARK 465     VAL W   338                                                      
REMARK 465     LEU W   339                                                      
REMARK 465     GLU W   340                                                      
REMARK 465     ASN W   341                                                      
REMARK 465     LEU W   342                                                      
REMARK 465     PRO W   343                                                      
REMARK 465     GLY W   344                                                      
REMARK 465     VAL W   345                                                      
REMARK 465     ASP W   346                                                      
REMARK 465     PRO W   347                                                      
REMARK 465     ASN W   348                                                      
REMARK 465     ASN W   349                                                      
REMARK 465     GLU W   350                                                      
REMARK 465     ALA W   351                                                      
REMARK 465     ILE W   352                                                      
REMARK 465     ARG W   353                                                      
REMARK 465     ASN W   354                                                      
REMARK 465     ALA W   355                                                      
REMARK 465     MET W   356                                                      
REMARK 465     GLY W   357                                                      
REMARK 465     SER W   358                                                      
REMARK 465     LEU W   359                                                      
REMARK 465     ALA W   360                                                      
REMARK 465     SER W   361                                                      
REMARK 465     GLN W   362                                                      
REMARK 465     ALA W   363                                                      
REMARK 465     THR W   364                                                      
REMARK 465     LYS W   365                                                      
REMARK 465     ASP W   366                                                      
REMARK 465     GLY W   367                                                      
REMARK 465     LYS W   368                                                      
REMARK 465     LYS W   369                                                      
REMARK 465     ASP W   370                                                      
REMARK 465     LYS W   371                                                      
REMARK 465     LYS W   372                                                      
REMARK 465     GLU W   373                                                      
REMARK 465     GLU W   374                                                      
REMARK 465     ASP W   375                                                      
REMARK 465     LYS W   376                                                      
REMARK 465     LYS W   377                                                      
REMARK 465     MET V     1                                                      
REMARK 465     ASP V     2                                                      
REMARK 465     ARG V     3                                                      
REMARK 465     LEU V     4                                                      
REMARK 465     LEU V     5                                                      
REMARK 465     ARG V     6                                                      
REMARK 465     LEU V     7                                                      
REMARK 465     GLY V     8                                                      
REMARK 465     GLY V     9                                                      
REMARK 465     GLY V    10                                                      
REMARK 465     MET V    11                                                      
REMARK 465     PRO V    12                                                      
REMARK 465     GLY V    13                                                      
REMARK 465     LEU V    14                                                      
REMARK 465     GLY V    15                                                      
REMARK 465     GLN V    16                                                      
REMARK 465     GLY V    17                                                      
REMARK 465     MET T     1                                                      
REMARK 465     PHE T     2                                                      
REMARK 465     ILE T     3                                                      
REMARK 465     LYS T     4                                                      
REMARK 465     GLY T     5                                                      
REMARK 465     ARG T     6                                                      
REMARK 465     ALA T     7                                                      
REMARK 465     PRO T     8                                                      
REMARK 465     ARG T     9                                                      
REMARK 465     ALA T    10                                                      
REMARK 465     PRO T    11                                                      
REMARK 465     PRO T    12                                                      
REMARK 465     ARG T    13                                                      
REMARK 465     GLU T    14                                                      
REMARK 465     ARG T    15                                                      
REMARK 465     ARG T    16                                                      
REMARK 465     ARG T    17                                                      
REMARK 465     ALA T    18                                                      
REMARK 465     THR T    19                                                      
REMARK 465     ARG T    20                                                      
REMARK 465     GLY T    21                                                      
REMARK 465     GLY T    22                                                      
REMARK 465     LEU T    23                                                      
REMARK 465     ARG T    24                                                      
REMARK 465     GLN T    25                                                      
REMARK 465     VAL T    26                                                      
REMARK 465     VAL T    27                                                      
REMARK 465     ALA T    28                                                      
REMARK 465     PRO T    29                                                      
REMARK 465     PRO T    30                                                      
REMARK 465     ARG T    31                                                      
REMARK 465     ALA T    32                                                      
REMARK 465     LEU T    33                                                      
REMARK 465     GLY T    34                                                      
REMARK 465     SER T    35                                                      
REMARK 465     THR T    36                                                      
REMARK 465     SER T    37                                                      
REMARK 465     ARG T    38                                                      
REMARK 465     PRO T    39                                                      
REMARK 465     HIS T    40                                                      
REMARK 465     PHE T    41                                                      
REMARK 465     ARG T    42                                                      
REMARK 465     ARG T    43                                                      
REMARK 465     ALA T    44                                                      
REMARK 465     SER T    45                                                      
REMARK 465     VAL T    46                                                      
REMARK 465     CYS T    47                                                      
REMARK 465     ARG T    48                                                      
REMARK 465     ARG T    49                                                      
REMARK 465     ARG T    50                                                      
REMARK 465     CYS T    51                                                      
REMARK 465     ARG T    52                                                      
REMARK 465     LYS T    53                                                      
REMARK 465     SER T    54                                                      
REMARK 465     GLY T    55                                                      
REMARK 465     GLY T    56                                                      
REMARK 465     LEU T    57                                                      
REMARK 465     LEU T    58                                                      
REMARK 465     ALA T    59                                                      
REMARK 465     ALA T    60                                                      
REMARK 465     SER T    61                                                      
REMARK 465     ARG T    62                                                      
REMARK 465     LYS T    63                                                      
REMARK 465     MET T    64                                                      
REMARK 465     ALA T    65                                                      
REMARK 465     ALA T    66                                                      
REMARK 465     ALA T    67                                                      
REMARK 465     ALA T    68                                                      
REMARK 465     VAL T    69                                                      
REMARK 465     ASN T    70                                                      
REMARK 465     GLY T    71                                                      
REMARK 465     ALA T    72                                                      
REMARK 465     ALA T    73                                                      
REMARK 465     GLY T    74                                                      
REMARK 465     PHE T    75                                                      
REMARK 465     SER T    76                                                      
REMARK 465     SER T    77                                                      
REMARK 465     SER T    78                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     SER Y     2                                                      
REMARK 465     GLU Y     3                                                      
REMARK 465     LYS Y     4                                                      
REMARK 465     LYS Y     5                                                      
REMARK 465     GLN Y     6                                                      
REMARK 465     PRO Y     7                                                      
REMARK 465     VAL Y     8                                                      
REMARK 465     ASP Y     9                                                      
REMARK 465     LEU Y    10                                                      
REMARK 465     GLY Y    11                                                      
REMARK 465     LEU Y    12                                                      
REMARK 465     LEU Y    13                                                      
REMARK 465     GLU Y    14                                                      
REMARK 465     GLN Z   826                                                      
REMARK 465     PRO Z   827                                                      
REMARK 465     ARG Z   828                                                      
REMARK 465     MET Z   829                                                      
REMARK 465     LEU Z   830                                                      
REMARK 465     VAL Z   831                                                      
REMARK 465     THR Z   832                                                      
REMARK 465     PHE Z   833                                                      
REMARK 465     ASP Z   834                                                      
REMARK 465     GLU Z   835                                                      
REMARK 465     GLU Z   836                                                      
REMARK 465     LEU Z   837                                                      
REMARK 465     ARG Z   838                                                      
REMARK 465     PRO Z   839                                                      
REMARK 465     LEU Z   840                                                      
REMARK 465     PRO Z   841                                                      
REMARK 465     VAL Z   842                                                      
REMARK 465     ILE Z   899                                                      
REMARK 465     LEU Z   900                                                      
REMARK 465     ARG Z   901                                                      
REMARK 465     LYS Z   902                                                      
REMARK 465     ASN Z   903                                                      
REMARK 465     PRO Z   904                                                      
REMARK 465     ASN Z   905                                                      
REMARK 465     TYR Z   906                                                      
REMARK 465     ASP Z   907                                                      
REMARK 465     LEU Z   908                                                      
REMARK 465     ILE N   275                                                      
REMARK 465     ALA N   276                                                      
REMARK 465     SER N   277                                                      
REMARK 465     VAL N   278                                                      
REMARK 465     PRO N   279                                                      
REMARK 465     GLY N   280                                                      
REMARK 465     SER N   281                                                      
REMARK 465     THR N   282                                                      
REMARK 465     ASN N   283                                                      
REMARK 465     THR N   284                                                      
REMARK 465     GLY N   285                                                      
REMARK 465     THR N   286                                                      
REMARK 465     VAL N   287                                                      
REMARK 465     PRO N   288                                                      
REMARK 465     GLY N   289                                                      
REMARK 465     SER N   290                                                      
REMARK 465     GLU N   291                                                      
REMARK 465     LYS N   292                                                      
REMARK 465     ASP N   293                                                      
REMARK 465     SER N   294                                                      
REMARK 465     ASP N   295                                                      
REMARK 465     SER N   296                                                      
REMARK 465     MET N   297                                                      
REMARK 465     GLU N   298                                                      
REMARK 465     THR N   299                                                      
REMARK 465     GLU N   300                                                      
REMARK 465     GLU N   301                                                      
REMARK 465     LYS N   302                                                      
REMARK 465     THR N   303                                                      
REMARK 465     SER N   304                                                      
REMARK 465     SER N   305                                                      
REMARK 465     ALA N   306                                                      
REMARK 465     PHE N   307                                                      
REMARK 465     VAL N   308                                                      
REMARK 465     GLY N   309                                                      
REMARK 465     LYS N   310                                                      
REMARK 465     THR N   311                                                      
REMARK 465     PRO N   312                                                      
REMARK 465     GLU N   313                                                      
REMARK 465     ALA N   314                                                      
REMARK 465     SER N   315                                                      
REMARK 465     PRO N   316                                                      
REMARK 465     GLU N   317                                                      
REMARK 465     PRO N   318                                                      
REMARK 465     LYS N   319                                                      
REMARK 465     ASP N   320                                                      
REMARK 465     GLN N   321                                                      
REMARK 465     MET N   854                                                      
REMARK 465     GLU N   855                                                      
REMARK 465     VAL N   856                                                      
REMARK 465     ASP N   857                                                      
REMARK 465     GLU N   858                                                      
REMARK 465     ALA N   859                                                      
REMARK 465     GLU N   860                                                      
REMARK 465     LYS N   861                                                      
REMARK 465     LYS N   862                                                      
REMARK 465     GLU N   863                                                      
REMARK 465     GLU N   864                                                      
REMARK 465     LYS N   865                                                      
REMARK 465     GLU N   866                                                      
REMARK 465     LYS N   867                                                      
REMARK 465     LYS N   868                                                      
REMARK 465     LYS N   869                                                      
REMARK 465     GLU N   870                                                      
REMARK 465     GLU N   941                                                      
REMARK 465     PRO N   942                                                      
REMARK 465     GLU N   943                                                      
REMARK 465     PRO N   944                                                      
REMARK 465     PRO N   945                                                      
REMARK 465     GLU N   946                                                      
REMARK 465     PRO N   947                                                      
REMARK 465     PHE N   948                                                      
REMARK 465     GLU N   949                                                      
REMARK 465     TYR N   950                                                      
REMARK 465     ILE N   951                                                      
REMARK 465     ASP N   952                                                      
REMARK 465     ASP N   953                                                      
REMARK 465     MET S     1                                                      
REMARK 465     LYS S     2                                                      
REMARK 465     GLN S     3                                                      
REMARK 465     GLU S     4                                                      
REMARK 465     GLY S     5                                                      
REMARK 465     SER S     6                                                      
REMARK 465     ALA S     7                                                      
REMARK 465     ARG S     8                                                      
REMARK 465     ARG S     9                                                      
REMARK 465     ARG S    10                                                      
REMARK 465     GLY S    11                                                      
REMARK 465     ALA S    12                                                      
REMARK 465     ASP S    13                                                      
REMARK 465     LYS S    14                                                      
REMARK 465     ALA S    15                                                      
REMARK 465     LYS S    16                                                      
REMARK 465     PRO S    17                                                      
REMARK 465     PRO S    18                                                      
REMARK 465     PRO S    19                                                      
REMARK 465     GLY S    20                                                      
REMARK 465     GLY S    21                                                      
REMARK 465     GLY S    22                                                      
REMARK 465     GLU S    23                                                      
REMARK 465     GLN S    24                                                      
REMARK 465     GLU S    25                                                      
REMARK 465     PRO S    26                                                      
REMARK 465     PRO S    27                                                      
REMARK 465     PRO S    28                                                      
REMARK 465     PRO S    29                                                      
REMARK 465     PRO S    30                                                      
REMARK 465     ALA S    31                                                      
REMARK 465     PRO S    32                                                      
REMARK 465     GLN S    33                                                      
REMARK 465     ASP S    34                                                      
REMARK 465     VAL S    35                                                      
REMARK 465     GLU S    36                                                      
REMARK 465     MET S    37                                                      
REMARK 465     LYS S    38                                                      
REMARK 465     GLU S    39                                                      
REMARK 465     GLU S    40                                                      
REMARK 465     ALA S    41                                                      
REMARK 465     ALA S    42                                                      
REMARK 465     THR S    43                                                      
REMARK 465     LYS U   293                                                      
REMARK 465     GLU U   294                                                      
REMARK 465     GLU U   295                                                      
REMARK 465     SER U   296                                                      
REMARK 465     LYS U   297                                                      
REMARK 465     LYS U   298                                                      
REMARK 465     ASP U   299                                                      
REMARK 465     ARG U   300                                                      
REMARK 465     LYS U   301                                                      
REMARK 465     GLU U   302                                                      
REMARK 465     ASP U   303                                                      
REMARK 465     LYS U   304                                                      
REMARK 465     GLU U   305                                                      
REMARK 465     LYS U   306                                                      
REMARK 465     ASP U   307                                                      
REMARK 465     LYS U   308                                                      
REMARK 465     ASP U   309                                                      
REMARK 465     LYS U   310                                                      
REMARK 465     GLU U   311                                                      
REMARK 465     LYS U   312                                                      
REMARK 465     SER U   313                                                      
REMARK 465     ASP U   314                                                      
REMARK 465     VAL U   315                                                      
REMARK 465     LYS U   316                                                      
REMARK 465     LYS U   317                                                      
REMARK 465     GLU U   318                                                      
REMARK 465     GLU U   319                                                      
REMARK 465     LYS U   320                                                      
REMARK 465     LYS U   321                                                      
REMARK 465     GLU U   322                                                      
REMARK 465     LYS U   323                                                      
REMARK 465     LYS U   324                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    ILE V   296     HB2  CYS V   299              1.04            
REMARK 500   O    ASP V   289    HG23  THR V   293              1.31            
REMARK 500   NE2  HIS V   237     HG2  GLN V   298              1.38            
REMARK 500   O    ASN O   227     HG1  THR O   228              1.45            
REMARK 500   O    ASP S   465     H    TYR S   467              1.46            
REMARK 500   H    GLY V   153     OE1  GLU U   173              1.47            
REMARK 500   O    MET V   292     H    ASN V   295              1.54            
REMARK 500   O    ALA R    51     H    TYR R    54              1.55            
REMARK 500   O    PHE R   194     H    ALA R   198              1.56            
REMARK 500   O    ALA R   289     H    HIS R   291              1.56            
REMARK 500   OD2  ASP V    71     H    VAL V    72              1.56            
REMARK 500   HH   TYR R   216     OE1  GLU R   245              1.57            
REMARK 500   O    GLN Q   405     HG   SER Q   408              1.57            
REMARK 500   O    ASP R   193     H    LYS R   195              1.59            
REMARK 500   OD1  ASP Z   636     HH   TYR Z   681              1.60            
REMARK 500   O    ILE V   296     CB   CYS V   299              2.01            
REMARK 500   O    ASP V   289     CG2  THR V   293              2.09            
REMARK 500   O    VAL V   297     N    CYS V   299              2.13            
REMARK 500   O    GLN R   365     N    GLN R   367              2.17            
REMARK 500   O    SER P    58     OG1  THR P    63              2.17            
REMARK 500   O    PHE P   403     NH1  ARG P   417              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    THR V 293   N     THR V 293   CA     -0.147                       
REMARK 500    SER V 294   N     SER V 294   CA     -0.159                       
REMARK 500    SER V 294   CA    SER V 294   C      -0.264                       
REMARK 500    ASN V 295   N     ASN V 295   CA     -0.253                       
REMARK 500    VAL V 297   N     VAL V 297   CA     -0.120                       
REMARK 500    VAL V 297   CA    VAL V 297   C      -0.175                       
REMARK 500    GLN V 298   N     GLN V 298   CA     -0.163                       
REMARK 500    CYS V 299   N     CYS V 299   CA     -0.126                       
REMARK 500    LYS T 324   C     PRO T 325   N       0.126                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    THR V 293   CA  -  C   -  O   ANGL. DEV. =  16.2 DEGREES          
REMARK 500    THR V 293   O   -  C   -  N   ANGL. DEV. = -13.0 DEGREES          
REMARK 500    SER V 294   C   -  N   -  CA  ANGL. DEV. = -17.4 DEGREES          
REMARK 500    ASN V 295   C   -  N   -  CA  ANGL. DEV. = -21.4 DEGREES          
REMARK 500    VAL V 297   C   -  N   -  CA  ANGL. DEV. = -20.5 DEGREES          
REMARK 500    VAL V 297   O   -  C   -  N   ANGL. DEV. = -12.3 DEGREES          
REMARK 500    VAL V 307   CA  -  CB  -  CG2 ANGL. DEV. = -11.2 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    MET W  16       39.90    -79.17                                   
REMARK 500    ARG W  17       51.34   -146.47                                   
REMARK 500    LEU W  22      140.95    -20.44                                   
REMARK 500    PRO W  23      -78.94     -7.18                                   
REMARK 500    ASN W  47      129.14   -170.13                                   
REMARK 500    LEU W  51       97.21   -172.80                                   
REMARK 500    ASN W  56     -120.37     62.08                                   
REMARK 500    GLU W 146      -29.67   -147.58                                   
REMARK 500    GLU W 151       92.14    -68.86                                   
REMARK 500    LYS W 163      -24.39   -158.25                                   
REMARK 500    SER W 168      123.74   -173.24                                   
REMARK 500    SER W 178       67.53     29.64                                   
REMARK 500    SER W 186      151.43    -43.98                                   
REMARK 500    LEU W 189       19.92   -151.08                                   
REMARK 500    ALA W 195       24.90   -149.14                                   
REMARK 500    VAL V  25      -27.42   -151.50                                   
REMARK 500    THR V  27      135.02   -176.34                                   
REMARK 500    PRO V  50      -79.22    -54.94                                   
REMARK 500    ASP V  63     -119.39     44.09                                   
REMARK 500    ASP V  64       10.67   -150.40                                   
REMARK 500    ALA V  74     -176.12    -63.67                                   
REMARK 500    SER V  78     -156.65    -92.37                                   
REMARK 500    PHE V 118     -150.51   -137.20                                   
REMARK 500    LYS V 152      111.47     62.30                                   
REMARK 500    VAL V 155       88.21     76.83                                   
REMARK 500    ILE V 157      115.89   -160.48                                   
REMARK 500    ASP V 158     -163.04   -110.57                                   
REMARK 500    ASN V 164       96.34    -58.46                                   
REMARK 500    THR V 177       91.15    -65.91                                   
REMARK 500    LEU V 181      -93.87    -76.86                                   
REMARK 500    HIS V 183        0.87   -174.46                                   
REMARK 500    LEU V 184      133.07     70.28                                   
REMARK 500    LYS V 186      -59.35   -149.81                                   
REMARK 500    GLN V 190      -75.13    -36.74                                   
REMARK 500    ARG V 198      -41.32   -167.74                                   
REMARK 500    SER V 224        0.21    -64.43                                   
REMARK 500    MET V 226     -154.28    -85.82                                   
REMARK 500    GLU V 227      161.98    -41.44                                   
REMARK 500    LEU V 231      140.60    167.74                                   
REMARK 500    LYS V 273       87.92    -66.95                                   
REMARK 500    LYS V 277        5.79    -68.10                                   
REMARK 500    CYS V 299      -70.08    -32.46                                   
REMARK 500    PRO T  80      173.80    -51.53                                   
REMARK 500    PRO T 130      143.50    -35.01                                   
REMARK 500    THR T 134      109.48     65.94                                   
REMARK 500    LYS T 159      175.94     80.41                                   
REMARK 500    ASP T 160      133.91     95.10                                   
REMARK 500    SER T 163      -80.11    -59.23                                   
REMARK 500    ALA T 169      -73.94    -50.71                                   
REMARK 500    GLU T 180      -90.15    -41.64                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     420 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 TYR T  241     ASN T  242                 -136.15                    
REMARK 500 HIS Z  102     TYR Z  103                  142.95                    
REMARK 500 VAL P  398     ASN P  399                 -137.29                    
REMARK 500 PRO R  234     ASP R  235                  136.65                    
REMARK 500 ALA O  254     TRP O  255                 -148.89                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    THR V 293        -10.32                                           
REMARK 500    SER V 294        -10.86                                           
REMARK 500    VAL V 297        -21.89                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-4002   RELATED DB: EMDB                              
DBREF  5L4K W    1   377  UNP    P55036   PSMD4_HUMAN      1    377             
DBREF  5L4K V    1   310  UNP    O00487   PSDE_HUMAN       1    310             
DBREF  5L4K T    1   350  UNP    P48556   PSMD8_HUMAN      1    350             
DBREF  5L4K Y    1    70  UNP    P60896   DSS1_HUMAN       1     70             
DBREF  5L4K Z    1   908  UNP    Q13200   PSMD2_HUMAN      1    908             
DBREF  5L4K N    1   953  UNP    Q99460   PSMD1_HUMAN      1    953             
DBREF  5L4K S    1   534  UNP    O43242   PSMD3_HUMAN      1    534             
DBREF  5L4K P    1   456  UNP    O00232   PSD12_HUMAN      1    456             
DBREF  5L4K Q    1   422  UNP    O00231   PSD11_HUMAN      1    422             
DBREF  5L4K R    1   389  UNP    Q15008   PSMD6_HUMAN      1    389             
DBREF  5L4K U    1   324  UNP    P51665   PSMD7_HUMAN      1    324             
DBREF  5L4K O    1   376  UNP    Q9UNM6   PSD13_HUMAN      1    376             
SEQRES   1 W  377  MET VAL LEU GLU SER THR MET VAL CYS VAL ASP ASN SER          
SEQRES   2 W  377  GLU TYR MET ARG ASN GLY ASP PHE LEU PRO THR ARG LEU          
SEQRES   3 W  377  GLN ALA GLN GLN ASP ALA VAL ASN ILE VAL CYS HIS SER          
SEQRES   4 W  377  LYS THR ARG SER ASN PRO GLU ASN ASN VAL GLY LEU ILE          
SEQRES   5 W  377  THR LEU ALA ASN ASP CYS GLU VAL LEU THR THR LEU THR          
SEQRES   6 W  377  PRO ASP THR GLY ARG ILE LEU SER LYS LEU HIS THR VAL          
SEQRES   7 W  377  GLN PRO LYS GLY LYS ILE THR PHE CYS THR GLY ILE ARG          
SEQRES   8 W  377  VAL ALA HIS LEU ALA LEU LYS HIS ARG GLN GLY LYS ASN          
SEQRES   9 W  377  HIS LYS MET ARG ILE ILE ALA PHE VAL GLY SER PRO VAL          
SEQRES  10 W  377  GLU ASP ASN GLU LYS ASP LEU VAL LYS LEU ALA LYS ARG          
SEQRES  11 W  377  LEU LYS LYS GLU LYS VAL ASN VAL ASP ILE ILE ASN PHE          
SEQRES  12 W  377  GLY GLU GLU GLU VAL ASN THR GLU LYS LEU THR ALA PHE          
SEQRES  13 W  377  VAL ASN THR LEU ASN GLY LYS ASP GLY THR GLY SER HIS          
SEQRES  14 W  377  LEU VAL THR VAL PRO PRO GLY PRO SER LEU ALA ASP ALA          
SEQRES  15 W  377  LEU ILE SER SER PRO ILE LEU ALA GLY GLU GLY GLY ALA          
SEQRES  16 W  377  MET LEU GLY LEU GLY ALA SER ASP PHE GLU PHE GLY VAL          
SEQRES  17 W  377  ASP PRO SER ALA ASP PRO GLU LEU ALA LEU ALA LEU ARG          
SEQRES  18 W  377  VAL SER MET GLU GLU GLN ARG GLN ARG GLN GLU GLU GLU          
SEQRES  19 W  377  ALA ARG ARG ALA ALA ALA ALA SER ALA ALA GLU ALA GLY          
SEQRES  20 W  377  ILE ALA THR THR GLY THR GLU ASP SER ASP ASP ALA LEU          
SEQRES  21 W  377  LEU LYS MET THR ILE SER GLN GLN GLU PHE GLY ARG THR          
SEQRES  22 W  377  GLY LEU PRO ASP LEU SER SER MET THR GLU GLU GLU GLN          
SEQRES  23 W  377  ILE ALA TYR ALA MET GLN MET SER LEU GLN GLY ALA GLU          
SEQRES  24 W  377  PHE GLY GLN ALA GLU SER ALA ASP ILE ASP ALA SER SER          
SEQRES  25 W  377  ALA MET ASP THR SER GLU PRO ALA LYS GLU GLU ASP ASP          
SEQRES  26 W  377  TYR ASP VAL MET GLN ASP PRO GLU PHE LEU GLN SER VAL          
SEQRES  27 W  377  LEU GLU ASN LEU PRO GLY VAL ASP PRO ASN ASN GLU ALA          
SEQRES  28 W  377  ILE ARG ASN ALA MET GLY SER LEU ALA SER GLN ALA THR          
SEQRES  29 W  377  LYS ASP GLY LYS LYS ASP LYS LYS GLU GLU ASP LYS LYS          
SEQRES   1 V  310  MET ASP ARG LEU LEU ARG LEU GLY GLY GLY MET PRO GLY          
SEQRES   2 V  310  LEU GLY GLN GLY PRO PRO THR ASP ALA PRO ALA VAL ASP          
SEQRES   3 V  310  THR ALA GLU GLN VAL TYR ILE SER SER LEU ALA LEU LEU          
SEQRES   4 V  310  LYS MET LEU LYS HIS GLY ARG ALA GLY VAL PRO MET GLU          
SEQRES   5 V  310  VAL MET GLY LEU MET LEU GLY GLU PHE VAL ASP ASP TYR          
SEQRES   6 V  310  THR VAL ARG VAL ILE ASP VAL PHE ALA MET PRO GLN SER          
SEQRES   7 V  310  GLY THR GLY VAL SER VAL GLU ALA VAL ASP PRO VAL PHE          
SEQRES   8 V  310  GLN ALA LYS MET LEU ASP MET LEU LYS GLN THR GLY ARG          
SEQRES   9 V  310  PRO GLU MET VAL VAL GLY TRP TYR HIS SER HIS PRO GLY          
SEQRES  10 V  310  PHE GLY CYS TRP LEU SER GLY VAL ASP ILE ASN THR GLN          
SEQRES  11 V  310  GLN SER PHE GLU ALA LEU SER GLU ARG ALA VAL ALA VAL          
SEQRES  12 V  310  VAL VAL ASP PRO ILE GLN SER VAL LYS GLY LYS VAL VAL          
SEQRES  13 V  310  ILE ASP ALA PHE ARG LEU ILE ASN ALA ASN MET MET VAL          
SEQRES  14 V  310  LEU GLY HIS GLU PRO ARG GLN THR THR SER ASN LEU GLY          
SEQRES  15 V  310  HIS LEU ASN LYS PRO SER ILE GLN ALA LEU ILE HIS GLY          
SEQRES  16 V  310  LEU ASN ARG HIS TYR TYR SER ILE THR ILE ASN TYR ARG          
SEQRES  17 V  310  LYS ASN GLU LEU GLU GLN LYS MET LEU LEU ASN LEU HIS          
SEQRES  18 V  310  LYS LYS SER TRP MET GLU GLY LEU THR LEU GLN ASP TYR          
SEQRES  19 V  310  SER GLU HIS CYS LYS HIS ASN GLU SER VAL VAL LYS GLU          
SEQRES  20 V  310  MET LEU GLU LEU ALA LYS ASN TYR ASN LYS ALA VAL GLU          
SEQRES  21 V  310  GLU GLU ASP LYS MET THR PRO GLU GLN LEU ALA ILE LYS          
SEQRES  22 V  310  ASN VAL GLY LYS GLN ASP PRO LYS ARG HIS LEU GLU GLU          
SEQRES  23 V  310  HIS VAL ASP VAL LEU MET THR SER ASN ILE VAL GLN CYS          
SEQRES  24 V  310  LEU ALA ALA MET LEU ASP THR VAL VAL PHE LYS                  
SEQRES   1 T  350  MET PHE ILE LYS GLY ARG ALA PRO ARG ALA PRO PRO ARG          
SEQRES   2 T  350  GLU ARG ARG ARG ALA THR ARG GLY GLY LEU ARG GLN VAL          
SEQRES   3 T  350  VAL ALA PRO PRO ARG ALA LEU GLY SER THR SER ARG PRO          
SEQRES   4 T  350  HIS PHE ARG ARG ALA SER VAL CYS ARG ARG ARG CYS ARG          
SEQRES   5 T  350  LYS SER GLY GLY LEU LEU ALA ALA SER ARG LYS MET ALA          
SEQRES   6 T  350  ALA ALA ALA VAL ASN GLY ALA ALA GLY PHE SER SER SER          
SEQRES   7 T  350  GLY PRO ALA ALA THR SER GLY ALA VAL LEU GLN ALA ALA          
SEQRES   8 T  350  THR GLY MET TYR GLU GLN LEU LYS GLY GLU TRP ASN ARG          
SEQRES   9 T  350  LYS SER PRO ASN LEU SER LYS CYS GLY GLU GLU LEU GLY          
SEQRES  10 T  350  ARG LEU LYS LEU VAL LEU LEU GLU LEU ASN PHE LEU PRO          
SEQRES  11 T  350  THR THR GLY THR LYS LEU THR LYS GLN GLN LEU ILE LEU          
SEQRES  12 T  350  ALA ARG ASP ILE LEU GLU ILE GLY ALA GLN TRP SER ILE          
SEQRES  13 T  350  LEU ARG LYS ASP ILE PRO SER PHE GLU ARG TYR MET ALA          
SEQRES  14 T  350  GLN LEU LYS CYS TYR TYR PHE ASP TYR LYS GLU GLN LEU          
SEQRES  15 T  350  PRO GLU SER ALA TYR MET HIS GLN LEU LEU GLY LEU ASN          
SEQRES  16 T  350  LEU LEU PHE LEU LEU SER GLN ASN ARG VAL ALA GLU PHE          
SEQRES  17 T  350  HIS THR GLU LEU GLU ARG LEU PRO ALA LYS ASP ILE GLN          
SEQRES  18 T  350  THR ASN VAL TYR ILE LYS HIS PRO VAL SER LEU GLU GLN          
SEQRES  19 T  350  TYR LEU MET GLU GLY SER TYR ASN LYS VAL PHE LEU ALA          
SEQRES  20 T  350  LYS GLY ASN ILE PRO ALA GLU SER TYR THR PHE PHE ILE          
SEQRES  21 T  350  ASP ILE LEU LEU ASP THR ILE ARG ASP GLU ILE ALA GLY          
SEQRES  22 T  350  CYS ILE GLU LYS ALA TYR GLU LYS ILE LEU PHE THR GLU          
SEQRES  23 T  350  ALA THR ARG ILE LEU PHE PHE ASN THR PRO LYS LYS MET          
SEQRES  24 T  350  THR ASP TYR ALA LYS LYS ARG GLY TRP VAL LEU GLY PRO          
SEQRES  25 T  350  ASN ASN TYR TYR SER PHE ALA SER GLN GLN GLN LYS PRO          
SEQRES  26 T  350  GLU ASP THR THR ILE PRO SER THR GLU LEU ALA LYS GLN          
SEQRES  27 T  350  VAL ILE GLU TYR ALA ARG GLN LEU GLU MET ILE VAL              
SEQRES   1 Y   70  MET SER GLU LYS LYS GLN PRO VAL ASP LEU GLY LEU LEU          
SEQRES   2 Y   70  GLU GLU ASP ASP GLU PHE GLU GLU PHE PRO ALA GLU ASP          
SEQRES   3 Y   70  TRP ALA GLY LEU ASP GLU ASP GLU ASP ALA HIS VAL TRP          
SEQRES   4 Y   70  GLU ASP ASN TRP ASP ASP ASP ASN VAL GLU ASP ASP PHE          
SEQRES   5 Y   70  SER ASN GLN LEU ARG ALA GLU LEU GLU LYS HIS GLY TYR          
SEQRES   6 Y   70  LYS MET GLU THR SER                                          
SEQRES   1 Z  908  MET GLU GLU GLY GLY ARG ASP LYS ALA PRO VAL GLN PRO          
SEQRES   2 Z  908  GLN GLN SER PRO ALA ALA ALA PRO GLY GLY THR ASP GLU          
SEQRES   3 Z  908  LYS PRO SER GLY LYS GLU ARG ARG ASP ALA GLY ASP LYS          
SEQRES   4 Z  908  ASP LYS GLU GLN GLU LEU SER GLU GLU ASP LYS GLN LEU          
SEQRES   5 Z  908  GLN ASP GLU LEU GLU MET LEU VAL GLU ARG LEU GLY GLU          
SEQRES   6 Z  908  LYS ASP THR SER LEU TYR ARG PRO ALA LEU GLU GLU LEU          
SEQRES   7 Z  908  ARG ARG GLN ILE ARG SER SER THR THR SER MET THR SER          
SEQRES   8 Z  908  VAL PRO LYS PRO LEU LYS PHE LEU ARG PRO HIS TYR GLY          
SEQRES   9 Z  908  LYS LEU LYS GLU ILE TYR GLU ASN MET ALA PRO GLY GLU          
SEQRES  10 Z  908  ASN LYS ARG PHE ALA ALA ASP ILE ILE SER VAL LEU ALA          
SEQRES  11 Z  908  MET THR MET SER GLY GLU ARG GLU CYS LEU LYS TYR ARG          
SEQRES  12 Z  908  LEU VAL GLY SER GLN GLU GLU LEU ALA SER TRP GLY HIS          
SEQRES  13 Z  908  GLU TYR VAL ARG HIS LEU ALA GLY GLU VAL ALA LYS GLU          
SEQRES  14 Z  908  TRP GLN GLU LEU ASP ASP ALA GLU LYS VAL GLN ARG GLU          
SEQRES  15 Z  908  PRO LEU LEU THR LEU VAL LYS GLU ILE VAL PRO TYR ASN          
SEQRES  16 Z  908  MET ALA HIS ASN ALA GLU HIS GLU ALA CYS ASP LEU LEU          
SEQRES  17 Z  908  MET GLU ILE GLU GLN VAL ASP MET LEU GLU LYS ASP ILE          
SEQRES  18 Z  908  ASP GLU ASN ALA TYR ALA LYS VAL CYS LEU TYR LEU THR          
SEQRES  19 Z  908  SER CYS VAL ASN TYR VAL PRO GLU PRO GLU ASN SER ALA          
SEQRES  20 Z  908  LEU LEU ARG CYS ALA LEU GLY VAL PHE ARG LYS PHE SER          
SEQRES  21 Z  908  ARG PHE PRO GLU ALA LEU ARG LEU ALA LEU MET LEU ASN          
SEQRES  22 Z  908  ASP MET GLU LEU VAL GLU ASP ILE PHE THR SER CYS LYS          
SEQRES  23 Z  908  ASP VAL VAL VAL GLN LYS GLN MET ALA PHE MET LEU GLY          
SEQRES  24 Z  908  ARG HIS GLY VAL PHE LEU GLU LEU SER GLU ASP VAL GLU          
SEQRES  25 Z  908  GLU TYR GLU ASP LEU THR GLU ILE MET SER ASN VAL GLN          
SEQRES  26 Z  908  LEU ASN SER ASN PHE LEU ALA LEU ALA ARG GLU LEU ASP          
SEQRES  27 Z  908  ILE MET GLU PRO LYS VAL PRO ASP ASP ILE TYR LYS THR          
SEQRES  28 Z  908  HIS LEU GLU ASN ASN ARG PHE GLY GLY SER GLY SER GLN          
SEQRES  29 Z  908  VAL ASP SER ALA ARG MET ASN LEU ALA SER SER PHE VAL          
SEQRES  30 Z  908  ASN GLY PHE VAL ASN ALA ALA PHE GLY GLN ASP LYS LEU          
SEQRES  31 Z  908  LEU THR ASP ASP GLY ASN LYS TRP LEU TYR LYS ASN LYS          
SEQRES  32 Z  908  ASP HIS GLY MET LEU SER ALA ALA ALA SER LEU GLY MET          
SEQRES  33 Z  908  ILE LEU LEU TRP ASP VAL ASP GLY GLY LEU THR GLN ILE          
SEQRES  34 Z  908  ASP LYS TYR LEU TYR SER SER GLU ASP TYR ILE LYS SER          
SEQRES  35 Z  908  GLY ALA LEU LEU ALA CYS GLY ILE VAL ASN SER GLY VAL          
SEQRES  36 Z  908  ARG ASN GLU CYS ASP PRO ALA LEU ALA LEU LEU SER ASP          
SEQRES  37 Z  908  TYR VAL LEU HIS ASN SER ASN THR MET ARG LEU GLY SER          
SEQRES  38 Z  908  ILE PHE GLY LEU GLY LEU ALA TYR ALA GLY SER ASN ARG          
SEQRES  39 Z  908  GLU ASP VAL LEU THR LEU LEU LEU PRO VAL MET GLY ASP          
SEQRES  40 Z  908  SER LYS SER SER MET GLU VAL ALA GLY VAL THR ALA LEU          
SEQRES  41 Z  908  ALA CYS GLY MET ILE ALA VAL GLY SER CYS ASN GLY ASP          
SEQRES  42 Z  908  VAL THR SER THR ILE LEU GLN THR ILE MET GLU LYS SER          
SEQRES  43 Z  908  GLU THR GLU LEU LYS ASP THR TYR ALA ARG TRP LEU PRO          
SEQRES  44 Z  908  LEU GLY LEU GLY LEU ASN HIS LEU GLY LYS GLY GLU ALA          
SEQRES  45 Z  908  ILE GLU ALA ILE LEU ALA ALA LEU GLU VAL VAL SER GLU          
SEQRES  46 Z  908  PRO PHE ARG SER PHE ALA ASN THR LEU VAL ASP VAL CYS          
SEQRES  47 Z  908  ALA TYR ALA GLY SER GLY ASN VAL LEU LYS VAL GLN GLN          
SEQRES  48 Z  908  LEU LEU HIS ILE CYS SER GLU HIS PHE ASP SER LYS GLU          
SEQRES  49 Z  908  LYS GLU GLU ASP LYS ASP LYS LYS GLU LYS LYS ASP LYS          
SEQRES  50 Z  908  ASP LYS LYS GLU ALA PRO ALA ASP MET GLY ALA HIS GLN          
SEQRES  51 Z  908  GLY VAL ALA VAL LEU GLY ILE ALA LEU ILE ALA MET GLY          
SEQRES  52 Z  908  GLU GLU ILE GLY ALA GLU MET ALA LEU ARG THR PHE GLY          
SEQRES  53 Z  908  HIS LEU LEU ARG TYR GLY GLU PRO THR LEU ARG ARG ALA          
SEQRES  54 Z  908  VAL PRO LEU ALA LEU ALA LEU ILE SER VAL SER ASN PRO          
SEQRES  55 Z  908  ARG LEU ASN ILE LEU ASP THR LEU SER LYS PHE SER HIS          
SEQRES  56 Z  908  ASP ALA ASP PRO GLU VAL SER TYR ASN SER ILE PHE ALA          
SEQRES  57 Z  908  MET GLY MET VAL GLY SER GLY THR ASN ASN ALA ARG LEU          
SEQRES  58 Z  908  ALA ALA MET LEU ARG GLN LEU ALA GLN TYR HIS ALA LYS          
SEQRES  59 Z  908  ASP PRO ASN ASN LEU PHE MET VAL ARG LEU ALA GLN GLY          
SEQRES  60 Z  908  LEU THR HIS LEU GLY LYS GLY THR LEU THR LEU CYS PRO          
SEQRES  61 Z  908  TYR HIS SER ASP ARG GLN LEU MET SER GLN VAL ALA VAL          
SEQRES  62 Z  908  ALA GLY LEU LEU THR VAL LEU VAL SER PHE LEU ASP VAL          
SEQRES  63 Z  908  ARG ASN ILE ILE LEU GLY LYS SER HIS TYR VAL LEU TYR          
SEQRES  64 Z  908  GLY LEU VAL ALA ALA MET GLN PRO ARG MET LEU VAL THR          
SEQRES  65 Z  908  PHE ASP GLU GLU LEU ARG PRO LEU PRO VAL SER VAL ARG          
SEQRES  66 Z  908  VAL GLY GLN ALA VAL ASP VAL VAL GLY GLN ALA GLY LYS          
SEQRES  67 Z  908  PRO LYS THR ILE THR GLY PHE GLN THR HIS THR THR PRO          
SEQRES  68 Z  908  VAL LEU LEU ALA HIS GLY GLU ARG ALA GLU LEU ALA THR          
SEQRES  69 Z  908  GLU GLU PHE LEU PRO VAL THR PRO ILE LEU GLU GLY PHE          
SEQRES  70 Z  908  VAL ILE LEU ARG LYS ASN PRO ASN TYR ASP LEU                  
SEQRES   1 N  953  MET ILE THR SER ALA ALA GLY ILE ILE SER LEU LEU ASP          
SEQRES   2 N  953  GLU ASP GLU PRO GLN LEU LYS GLU PHE ALA LEU HIS LYS          
SEQRES   3 N  953  LEU ASN ALA VAL VAL ASN ASP PHE TRP ALA GLU ILE SER          
SEQRES   4 N  953  GLU SER VAL ASP LYS ILE GLU VAL LEU TYR GLU ASP GLU          
SEQRES   5 N  953  GLY PHE ARG SER ARG GLN PHE ALA ALA LEU VAL ALA SER          
SEQRES   6 N  953  LYS VAL PHE TYR HIS LEU GLY ALA PHE GLU GLU SER LEU          
SEQRES   7 N  953  ASN TYR ALA LEU GLY ALA GLY ASP LEU PHE ASN VAL ASN          
SEQRES   8 N  953  ASP ASN SER GLU TYR VAL GLU THR ILE ILE ALA LYS CYS          
SEQRES   9 N  953  ILE ASP HIS TYR THR LYS GLN CYS VAL GLU ASN ALA ASP          
SEQRES  10 N  953  LEU PRO GLU GLY GLU LYS LYS PRO ILE ASP GLN ARG LEU          
SEQRES  11 N  953  GLU GLY ILE VAL ASN LYS MET PHE GLN ARG CYS LEU ASP          
SEQRES  12 N  953  ASP HIS LYS TYR LYS GLN ALA ILE GLY ILE ALA LEU GLU          
SEQRES  13 N  953  THR ARG ARG LEU ASP VAL PHE GLU LYS THR ILE LEU GLU          
SEQRES  14 N  953  SER ASN ASP VAL PRO GLY MET LEU ALA TYR SER LEU LYS          
SEQRES  15 N  953  LEU CYS MET SER LEU MET GLN ASN LYS GLN PHE ARG ASN          
SEQRES  16 N  953  LYS VAL LEU ARG VAL LEU VAL LYS ILE TYR MET ASN LEU          
SEQRES  17 N  953  GLU LYS PRO ASP PHE ILE ASN VAL CYS GLN CYS LEU ILE          
SEQRES  18 N  953  PHE LEU ASP ASP PRO GLN ALA VAL SER ASP ILE LEU GLU          
SEQRES  19 N  953  LYS LEU VAL LYS GLU ASP ASN LEU LEU MET ALA TYR GLN          
SEQRES  20 N  953  ILE CYS PHE ASP LEU TYR GLU SER ALA SER GLN GLN PHE          
SEQRES  21 N  953  LEU SER SER VAL ILE GLN ASN LEU ARG THR VAL GLY THR          
SEQRES  22 N  953  PRO ILE ALA SER VAL PRO GLY SER THR ASN THR GLY THR          
SEQRES  23 N  953  VAL PRO GLY SER GLU LYS ASP SER ASP SER MET GLU THR          
SEQRES  24 N  953  GLU GLU LYS THR SER SER ALA PHE VAL GLY LYS THR PRO          
SEQRES  25 N  953  GLU ALA SER PRO GLU PRO LYS ASP GLN THR LEU LYS MET          
SEQRES  26 N  953  ILE LYS ILE LEU SER GLY GLU MET ALA ILE GLU LEU HIS          
SEQRES  27 N  953  LEU GLN PHE LEU ILE ARG ASN ASN ASN THR ASP LEU MET          
SEQRES  28 N  953  ILE LEU LYS ASN THR LYS ASP ALA VAL ARG ASN SER VAL          
SEQRES  29 N  953  CYS HIS THR ALA THR VAL ILE ALA ASN SER PHE MET HIS          
SEQRES  30 N  953  CYS GLY THR THR SER ASP GLN PHE LEU ARG ASP ASN LEU          
SEQRES  31 N  953  GLU TRP LEU ALA ARG ALA THR ASN TRP ALA LYS PHE THR          
SEQRES  32 N  953  ALA THR ALA SER LEU GLY VAL ILE HIS LYS GLY HIS GLU          
SEQRES  33 N  953  LYS GLU ALA LEU GLN LEU MET ALA THR TYR LEU PRO LYS          
SEQRES  34 N  953  ASP THR SER PRO GLY SER ALA TYR GLN GLU GLY GLY GLY          
SEQRES  35 N  953  LEU TYR ALA LEU GLY LEU ILE HIS ALA ASN HIS GLY GLY          
SEQRES  36 N  953  ASP ILE ILE ASP TYR LEU LEU ASN GLN LEU LYS ASN ALA          
SEQRES  37 N  953  SER ASN ASP ILE VAL ARG HIS GLY GLY SER LEU GLY LEU          
SEQRES  38 N  953  GLY LEU ALA ALA MET GLY THR ALA ARG GLN ASP VAL TYR          
SEQRES  39 N  953  ASP LEU LEU LYS THR ASN LEU TYR GLN ASP ASP ALA VAL          
SEQRES  40 N  953  THR GLY GLU ALA ALA GLY LEU ALA LEU GLY LEU VAL MET          
SEQRES  41 N  953  LEU GLY SER LYS ASN ALA GLN ALA ILE GLU ASP MET VAL          
SEQRES  42 N  953  GLY TYR ALA GLN GLU THR GLN HIS GLU LYS ILE LEU ARG          
SEQRES  43 N  953  GLY LEU ALA VAL GLY ILE ALA LEU VAL MET TYR GLY ARG          
SEQRES  44 N  953  MET GLU GLU ALA ASP ALA LEU ILE GLU SER LEU CYS ARG          
SEQRES  45 N  953  ASP LYS ASP PRO ILE LEU ARG ARG SER GLY MET TYR THR          
SEQRES  46 N  953  VAL ALA MET ALA TYR CYS GLY SER GLY ASN ASN LYS ALA          
SEQRES  47 N  953  ILE ARG ARG LEU LEU HIS VAL ALA VAL SER ASP VAL ASN          
SEQRES  48 N  953  ASP ASP VAL ARG ARG ALA ALA VAL GLU SER LEU GLY PHE          
SEQRES  49 N  953  ILE LEU PHE ARG THR PRO GLU GLN CYS PRO SER VAL VAL          
SEQRES  50 N  953  SER LEU LEU SER GLU SER TYR ASN PRO HIS VAL ARG TYR          
SEQRES  51 N  953  GLY ALA ALA MET ALA LEU GLY ILE CYS CYS ALA GLY THR          
SEQRES  52 N  953  GLY ASN LYS GLU ALA ILE ASN LEU LEU GLU PRO MET THR          
SEQRES  53 N  953  ASN ASP PRO VAL ASN TYR VAL ARG GLN GLY ALA LEU ILE          
SEQRES  54 N  953  ALA SER ALA LEU ILE MET ILE GLN GLN THR GLU ILE THR          
SEQRES  55 N  953  CYS PRO LYS VAL ASN GLN PHE ARG GLN LEU TYR SER LYS          
SEQRES  56 N  953  VAL ILE ASN ASP LYS HIS ASP ASP VAL MET ALA LYS PHE          
SEQRES  57 N  953  GLY ALA ILE LEU ALA GLN GLY ILE LEU ASP ALA GLY GLY          
SEQRES  58 N  953  HIS ASN VAL THR ILE SER LEU GLN SER ARG THR GLY HIS          
SEQRES  59 N  953  THR HIS MET PRO SER VAL VAL GLY VAL LEU VAL PHE THR          
SEQRES  60 N  953  GLN PHE TRP PHE TRP PHE PRO LEU SER HIS PHE LEU SER          
SEQRES  61 N  953  LEU ALA TYR THR PRO THR CYS VAL ILE GLY LEU ASN LYS          
SEQRES  62 N  953  ASP LEU LYS MET PRO LYS VAL GLN TYR LYS SER ASN CYS          
SEQRES  63 N  953  LYS PRO SER THR PHE ALA TYR PRO ALA PRO LEU GLU VAL          
SEQRES  64 N  953  PRO LYS GLU LYS GLU LYS GLU LYS VAL SER THR ALA VAL          
SEQRES  65 N  953  LEU SER ILE THR ALA LYS ALA LYS LYS LYS GLU LYS GLU          
SEQRES  66 N  953  LYS GLU LYS LYS GLU GLU GLU LYS MET GLU VAL ASP GLU          
SEQRES  67 N  953  ALA GLU LYS LYS GLU GLU LYS GLU LYS LYS LYS GLU PRO          
SEQRES  68 N  953  GLU PRO ASN PHE GLN LEU LEU ASP ASN PRO ALA ARG VAL          
SEQRES  69 N  953  MET PRO ALA GLN LEU LYS VAL LEU THR MET PRO GLU THR          
SEQRES  70 N  953  CYS ARG TYR GLN PRO PHE LYS PRO LEU SER ILE GLY GLY          
SEQRES  71 N  953  ILE ILE ILE LEU LYS ASP THR SER GLU ASP ILE GLU GLU          
SEQRES  72 N  953  LEU VAL GLU PRO VAL ALA ALA HIS GLY PRO LYS ILE GLU          
SEQRES  73 N  953  GLU GLU GLU GLN GLU PRO GLU PRO PRO GLU PRO PHE GLU          
SEQRES  74 N  953  TYR ILE ASP ASP                                              
SEQRES   1 S  534  MET LYS GLN GLU GLY SER ALA ARG ARG ARG GLY ALA ASP          
SEQRES   2 S  534  LYS ALA LYS PRO PRO PRO GLY GLY GLY GLU GLN GLU PRO          
SEQRES   3 S  534  PRO PRO PRO PRO ALA PRO GLN ASP VAL GLU MET LYS GLU          
SEQRES   4 S  534  GLU ALA ALA THR GLY GLY GLY SER THR GLY GLU ALA ASP          
SEQRES   5 S  534  GLY LYS THR ALA ALA ALA ALA ALA GLU HIS SER GLN ARG          
SEQRES   6 S  534  GLU LEU ASP THR VAL THR LEU GLU ASP ILE LYS GLU HIS          
SEQRES   7 S  534  VAL LYS GLN LEU GLU LYS ALA VAL SER GLY LYS GLU PRO          
SEQRES   8 S  534  ARG PHE VAL LEU ARG ALA LEU ARG MET LEU PRO SER THR          
SEQRES   9 S  534  SER ARG ARG LEU ASN HIS TYR VAL LEU TYR LYS ALA VAL          
SEQRES  10 S  534  GLN GLY PHE PHE THR SER ASN ASN ALA THR ARG ASP PHE          
SEQRES  11 S  534  LEU LEU PRO PHE LEU GLU GLU PRO MET ASP THR GLU ALA          
SEQRES  12 S  534  ASP LEU GLN PHE ARG PRO ARG THR GLY LYS ALA ALA SER          
SEQRES  13 S  534  THR PRO LEU LEU PRO GLU VAL GLU ALA TYR LEU GLN LEU          
SEQRES  14 S  534  LEU VAL VAL ILE PHE MET MET ASN SER LYS ARG TYR LYS          
SEQRES  15 S  534  GLU ALA GLN LYS ILE SER ASP ASP LEU MET GLN LYS ILE          
SEQRES  16 S  534  SER THR GLN ASN ARG ARG ALA LEU ASP LEU VAL ALA ALA          
SEQRES  17 S  534  LYS CYS TYR TYR TYR HIS ALA ARG VAL TYR GLU PHE LEU          
SEQRES  18 S  534  ASP LYS LEU ASP VAL VAL ARG SER PHE LEU HIS ALA ARG          
SEQRES  19 S  534  LEU ARG THR ALA THR LEU ARG HIS ASP ALA ASP GLY GLN          
SEQRES  20 S  534  ALA THR LEU LEU ASN LEU LEU LEU ARG ASN TYR LEU HIS          
SEQRES  21 S  534  TYR SER LEU TYR ASP GLN ALA GLU LYS LEU VAL SER LYS          
SEQRES  22 S  534  SER VAL PHE PRO GLU GLN ALA ASN ASN ASN GLU TRP ALA          
SEQRES  23 S  534  ARG TYR LEU TYR TYR THR GLY ARG ILE LYS ALA ILE GLN          
SEQRES  24 S  534  LEU GLU TYR SER GLU ALA ARG ARG THR MET THR ASN ALA          
SEQRES  25 S  534  LEU ARG LYS ALA PRO GLN HIS THR ALA VAL GLY PHE LYS          
SEQRES  26 S  534  GLN THR VAL HIS LYS LEU LEU ILE VAL VAL GLU LEU LEU          
SEQRES  27 S  534  LEU GLY GLU ILE PRO ASP ARG LEU GLN PHE ARG GLN PRO          
SEQRES  28 S  534  SER LEU LYS ARG SER LEU MET PRO TYR PHE LEU LEU THR          
SEQRES  29 S  534  GLN ALA VAL ARG THR GLY ASN LEU ALA LYS PHE ASN GLN          
SEQRES  30 S  534  VAL LEU ASP GLN PHE GLY GLU LYS PHE GLN ALA ASP GLY          
SEQRES  31 S  534  THR TYR THR LEU ILE ILE ARG LEU ARG HIS ASN VAL ILE          
SEQRES  32 S  534  LYS THR GLY VAL ARG MET ILE SER LEU SER TYR SER ARG          
SEQRES  33 S  534  ILE SER LEU ALA ASP ILE ALA GLN LYS LEU GLN LEU ASP          
SEQRES  34 S  534  SER PRO GLU ASP ALA GLU PHE ILE VAL ALA LYS ALA ILE          
SEQRES  35 S  534  ARG ASP GLY VAL ILE GLU ALA SER ILE ASN HIS GLU LYS          
SEQRES  36 S  534  GLY TYR VAL GLN SER LYS GLU MET ILE ASP ILE TYR SER          
SEQRES  37 S  534  THR ARG GLU PRO GLN LEU ALA PHE HIS GLN ARG ILE SER          
SEQRES  38 S  534  PHE CYS LEU ASP ILE HIS ASN MET SER VAL LYS ALA MET          
SEQRES  39 S  534  ARG PHE PRO PRO LYS SER TYR ASN LYS ASP LEU GLU SER          
SEQRES  40 S  534  ALA GLU GLU ARG ARG GLU ARG GLU GLN GLN ASP LEU GLU          
SEQRES  41 S  534  PHE ALA LYS GLU MET ALA GLU ASP ASP ASP ASP SER PHE          
SEQRES  42 S  534  PRO                                                          
SEQRES   1 P  456  MET ALA ASP GLY GLY SER GLU ARG ALA ASP GLY ARG ILE          
SEQRES   2 P  456  VAL LYS MET GLU VAL ASP TYR SER ALA THR VAL ASP GLN          
SEQRES   3 P  456  ARG LEU PRO GLU CYS ALA LYS LEU ALA LYS GLU GLY ARG          
SEQRES   4 P  456  LEU GLN GLU VAL ILE GLU THR LEU LEU SER LEU GLU LYS          
SEQRES   5 P  456  GLN THR ARG THR ALA SER ASP MET VAL SER THR SER ARG          
SEQRES   6 P  456  ILE LEU VAL ALA VAL VAL LYS MET CYS TYR GLU ALA LYS          
SEQRES   7 P  456  GLU TRP ASP LEU LEU ASN GLU ASN ILE MET LEU LEU SER          
SEQRES   8 P  456  LYS ARG ARG SER GLN LEU LYS GLN ALA VAL ALA LYS MET          
SEQRES   9 P  456  VAL GLN GLN CYS CYS THR TYR VAL GLU GLU ILE THR ASP          
SEQRES  10 P  456  LEU PRO ILE LYS LEU ARG LEU ILE ASP THR LEU ARG MET          
SEQRES  11 P  456  VAL THR GLU GLY LYS ILE TYR VAL GLU ILE GLU ARG ALA          
SEQRES  12 P  456  ARG LEU THR LYS THR LEU ALA THR ILE LYS GLU GLN ASN          
SEQRES  13 P  456  GLY ASP VAL LYS GLU ALA ALA SER ILE LEU GLN GLU LEU          
SEQRES  14 P  456  GLN VAL GLU THR TYR GLY SER MET GLU LYS LYS GLU ARG          
SEQRES  15 P  456  VAL GLU PHE ILE LEU GLU GLN MET ARG LEU CYS LEU ALA          
SEQRES  16 P  456  VAL LYS ASP TYR ILE ARG THR GLN ILE ILE SER LYS LYS          
SEQRES  17 P  456  ILE ASN THR LYS PHE PHE GLN GLU GLU ASN THR GLU LYS          
SEQRES  18 P  456  LEU LYS LEU LYS TYR TYR ASN LEU MET ILE GLN LEU ASP          
SEQRES  19 P  456  GLN HIS GLU GLY SER TYR LEU SER ILE CYS LYS HIS TYR          
SEQRES  20 P  456  ARG ALA ILE TYR ASP THR PRO CYS ILE GLN ALA GLU SER          
SEQRES  21 P  456  GLU LYS TRP GLN GLN ALA LEU LYS SER VAL VAL LEU TYR          
SEQRES  22 P  456  VAL ILE LEU ALA PRO PHE ASP ASN GLU GLN SER ASP LEU          
SEQRES  23 P  456  VAL HIS ARG ILE SER GLY ASP LYS LYS LEU GLU GLU ILE          
SEQRES  24 P  456  PRO LYS TYR LYS ASP LEU LEU LYS LEU PHE THR THR MET          
SEQRES  25 P  456  GLU LEU MET ARG TRP SER THR LEU VAL GLU ASP TYR GLY          
SEQRES  26 P  456  MET GLU LEU ARG LYS GLY SER LEU GLU SER PRO ALA THR          
SEQRES  27 P  456  ASP VAL PHE GLY SER THR GLU GLU GLY GLU LYS ARG TRP          
SEQRES  28 P  456  LYS ASP LEU LYS ASN ARG VAL VAL GLU HIS ASN ILE ARG          
SEQRES  29 P  456  ILE MET ALA LYS TYR TYR THR ARG ILE THR MET LYS ARG          
SEQRES  30 P  456  MET ALA GLN LEU LEU ASP LEU SER VAL ASP GLU SER GLU          
SEQRES  31 P  456  ALA PHE LEU SER ASN LEU VAL VAL ASN LYS THR ILE PHE          
SEQRES  32 P  456  ALA LYS VAL ASP ARG LEU ALA GLY ILE ILE ASN PHE GLN          
SEQRES  33 P  456  ARG PRO LYS ASP PRO ASN ASN LEU LEU ASN ASP TRP SER          
SEQRES  34 P  456  GLN LYS LEU ASN SER LEU MET SER LEU VAL ASN LYS THR          
SEQRES  35 P  456  THR HIS LEU ILE ALA LYS GLU GLU MET ILE HIS ASN LEU          
SEQRES  36 P  456  GLN                                                          
SEQRES   1 Q  422  MET ALA ALA ALA ALA VAL VAL GLU PHE GLN ARG ALA GLN          
SEQRES   2 Q  422  SER LEU LEU SER THR ASP ARG GLU ALA SER ILE ASP ILE          
SEQRES   3 Q  422  LEU HIS SER ILE VAL LYS ARG ASP ILE GLN GLU ASN ASP          
SEQRES   4 Q  422  GLU GLU ALA VAL GLN VAL LYS GLU GLN SER ILE LEU GLU          
SEQRES   5 Q  422  LEU GLY SER LEU LEU ALA LYS THR GLY GLN ALA ALA GLU          
SEQRES   6 Q  422  LEU GLY GLY LEU LEU LYS TYR VAL ARG PRO PHE LEU ASN          
SEQRES   7 Q  422  SER ILE SER LYS ALA LYS ALA ALA ARG LEU VAL ARG SER          
SEQRES   8 Q  422  LEU LEU ASP LEU PHE LEU ASP MET GLU ALA ALA THR GLY          
SEQRES   9 Q  422  GLN GLU VAL GLU LEU CYS LEU GLU CYS ILE GLU TRP ALA          
SEQRES  10 Q  422  LYS SER GLU LYS ARG THR PHE LEU ARG GLN ALA LEU GLU          
SEQRES  11 Q  422  ALA ARG LEU VAL SER LEU TYR PHE ASP THR LYS ARG TYR          
SEQRES  12 Q  422  GLN GLU ALA LEU HIS LEU GLY SER GLN LEU LEU ARG GLU          
SEQRES  13 Q  422  LEU LYS LYS MET ASP ASP LYS ALA LEU LEU VAL GLU VAL          
SEQRES  14 Q  422  GLN LEU LEU GLU SER LYS THR TYR HIS ALA LEU SER ASN          
SEQRES  15 Q  422  LEU PRO LYS ALA ARG ALA ALA LEU THR SER ALA ARG THR          
SEQRES  16 Q  422  THR ALA ASN ALA ILE TYR CYS PRO PRO LYS LEU GLN ALA          
SEQRES  17 Q  422  THR LEU ASP MET GLN SER GLY ILE ILE HIS ALA ALA GLU          
SEQRES  18 Q  422  GLU LYS ASP TRP LYS THR ALA TYR SER TYR PHE TYR GLU          
SEQRES  19 Q  422  ALA PHE GLU GLY TYR ASP SER ILE ASP SER PRO LYS ALA          
SEQRES  20 Q  422  ILE THR SER LEU LYS TYR MET LEU LEU CYS LYS ILE MET          
SEQRES  21 Q  422  LEU ASN THR PRO GLU ASP VAL GLN ALA LEU VAL SER GLY          
SEQRES  22 Q  422  LYS LEU ALA LEU ARG TYR ALA GLY ARG GLN THR GLU ALA          
SEQRES  23 Q  422  LEU LYS CYS VAL ALA GLN ALA SER LYS ASN ARG SER LEU          
SEQRES  24 Q  422  ALA ASP PHE GLU LYS ALA LEU THR ASP TYR ARG ALA GLU          
SEQRES  25 Q  422  LEU ARG ASP ASP PRO ILE ILE SER THR HIS LEU ALA LYS          
SEQRES  26 Q  422  LEU TYR ASP ASN LEU LEU GLU GLN ASN LEU ILE ARG VAL          
SEQRES  27 Q  422  ILE GLU PRO PHE SER ARG VAL GLN ILE GLU HIS ILE SER          
SEQRES  28 Q  422  SER LEU ILE LYS LEU SER LYS ALA ASP VAL GLU ARG LYS          
SEQRES  29 Q  422  LEU SER GLN MET ILE LEU ASP LYS LYS PHE HIS GLY ILE          
SEQRES  30 Q  422  LEU ASP GLN GLY GLU GLY VAL LEU ILE ILE PHE ASP GLU          
SEQRES  31 Q  422  PRO PRO VAL ASP LYS THR TYR GLU ALA ALA LEU GLU THR          
SEQRES  32 Q  422  ILE GLN ASN MET SER LYS VAL VAL ASP SER LEU TYR ASN          
SEQRES  33 Q  422  LYS ALA LYS LYS LEU THR                                      
SEQRES   1 R  389  MET PRO LEU GLU ASN LEU GLU GLU GLU GLY LEU PRO LYS          
SEQRES   2 R  389  ASN PRO ASP LEU ARG ILE ALA GLN LEU ARG PHE LEU LEU          
SEQRES   3 R  389  SER LEU PRO GLU HIS ARG GLY ASP ALA ALA VAL ARG ASP          
SEQRES   4 R  389  GLU LEU MET ALA ALA VAL ARG ASP ASN ASN MET ALA PRO          
SEQRES   5 R  389  TYR TYR GLU ALA LEU CYS LYS SER LEU ASP TRP GLN ILE          
SEQRES   6 R  389  ASP VAL ASP LEU LEU ASN LYS MET LYS LYS ALA ASN GLU          
SEQRES   7 R  389  ASP GLU LEU LYS ARG LEU ASP GLU GLU LEU GLU ASP ALA          
SEQRES   8 R  389  GLU LYS ASN LEU GLY GLU SER GLU ILE ARG ASP ALA MET          
SEQRES   9 R  389  MET ALA LYS ALA GLU TYR LEU CYS ARG ILE GLY ASP LYS          
SEQRES  10 R  389  GLU GLY ALA LEU THR ALA PHE ARG LYS THR TYR ASP LYS          
SEQRES  11 R  389  THR VAL ALA LEU GLY HIS ARG LEU ASP ILE VAL PHE TYR          
SEQRES  12 R  389  LEU LEU ARG ILE GLY LEU PHE TYR MET ASP ASN ASP LEU          
SEQRES  13 R  389  ILE THR ARG ASN THR GLU LYS ALA LYS SER LEU ILE GLU          
SEQRES  14 R  389  GLU GLY GLY ASP TRP ASP ARG ARG ASN ARG LEU LYS VAL          
SEQRES  15 R  389  TYR GLN GLY LEU TYR CYS VAL ALA ILE ARG ASP PHE LYS          
SEQRES  16 R  389  GLN ALA ALA GLU LEU PHE LEU ASP THR VAL SER THR PHE          
SEQRES  17 R  389  THR SER TYR GLU LEU MET ASP TYR LYS THR PHE VAL THR          
SEQRES  18 R  389  TYR THR VAL TYR VAL SER MET ILE ALA LEU GLU ARG PRO          
SEQRES  19 R  389  ASP LEU ARG GLU LYS VAL ILE LYS GLY ALA GLU ILE LEU          
SEQRES  20 R  389  GLU VAL LEU HIS SER LEU PRO ALA VAL ARG GLN TYR LEU          
SEQRES  21 R  389  PHE SER LEU TYR GLU CYS ARG TYR SER VAL PHE PHE GLN          
SEQRES  22 R  389  SER LEU ALA VAL VAL GLU GLN GLU MET LYS LYS ASP TRP          
SEQRES  23 R  389  LEU PHE ALA PRO HIS TYR ARG TYR TYR VAL ARG GLU MET          
SEQRES  24 R  389  ARG ILE HIS ALA TYR SER GLN LEU LEU GLU SER TYR ARG          
SEQRES  25 R  389  SER LEU THR LEU GLY TYR MET ALA GLU ALA PHE GLY VAL          
SEQRES  26 R  389  GLY VAL GLU PHE ILE ASP GLN GLU LEU SER ARG PHE ILE          
SEQRES  27 R  389  ALA ALA GLY ARG LEU HIS CYS LYS ILE ASP LYS VAL ASN          
SEQRES  28 R  389  GLU ILE VAL GLU THR ASN ARG PRO ASP SER LYS ASN TRP          
SEQRES  29 R  389  GLN TYR GLN GLU THR ILE LYS LYS GLY ASP LEU LEU LEU          
SEQRES  30 R  389  ASN ARG VAL GLN LYS LEU SER ARG VAL ILE ASN MET              
SEQRES   1 U  324  MET PRO GLU LEU ALA VAL GLN LYS VAL VAL VAL HIS PRO          
SEQRES   2 U  324  LEU VAL LEU LEU SER VAL VAL ASP HIS PHE ASN ARG ILE          
SEQRES   3 U  324  GLY LYS VAL GLY ASN GLN LYS ARG VAL VAL GLY VAL LEU          
SEQRES   4 U  324  LEU GLY SER TRP GLN LYS LYS VAL LEU ASP VAL SER ASN          
SEQRES   5 U  324  SER PHE ALA VAL PRO PHE ASP GLU ASP ASP LYS ASP ASP          
SEQRES   6 U  324  SER VAL TRP PHE LEU ASP HIS ASP TYR LEU GLU ASN MET          
SEQRES   7 U  324  TYR GLY MET PHE LYS LYS VAL ASN ALA ARG GLU ARG ILE          
SEQRES   8 U  324  VAL GLY TRP TYR HIS THR GLY PRO LYS LEU HIS LYS ASN          
SEQRES   9 U  324  ASP ILE ALA ILE ASN GLU LEU MET LYS ARG TYR CYS PRO          
SEQRES  10 U  324  ASN SER VAL LEU VAL ILE ILE ASP VAL LYS PRO LYS ASP          
SEQRES  11 U  324  LEU GLY LEU PRO THR GLU ALA TYR ILE SER VAL GLU GLU          
SEQRES  12 U  324  VAL HIS ASP ASP GLY THR PRO THR SER LYS THR PHE GLU          
SEQRES  13 U  324  HIS VAL THR SER GLU ILE GLY ALA GLU GLU ALA GLU GLU          
SEQRES  14 U  324  VAL GLY VAL GLU HIS LEU LEU ARG ASP ILE LYS ASP THR          
SEQRES  15 U  324  THR VAL GLY THR LEU SER GLN ARG ILE THR ASN GLN VAL          
SEQRES  16 U  324  HIS GLY LEU LYS GLY LEU ASN SER LYS LEU LEU ASP ILE          
SEQRES  17 U  324  ARG SER TYR LEU GLU LYS VAL ALA THR GLY LYS LEU PRO          
SEQRES  18 U  324  ILE ASN HIS GLN ILE ILE TYR GLN LEU GLN ASP VAL PHE          
SEQRES  19 U  324  ASN LEU LEU PRO ASP VAL SER LEU GLN GLU PHE VAL LYS          
SEQRES  20 U  324  ALA PHE TYR LEU LYS THR ASN ASP GLN MET VAL VAL VAL          
SEQRES  21 U  324  TYR LEU ALA SER LEU ILE ARG SER VAL VAL ALA LEU HIS          
SEQRES  22 U  324  ASN LEU ILE ASN ASN LYS ILE ALA ASN ARG ASP ALA GLU          
SEQRES  23 U  324  LYS LYS GLU GLY GLN GLU LYS GLU GLU SER LYS LYS ASP          
SEQRES  24 U  324  ARG LYS GLU ASP LYS GLU LYS ASP LYS ASP LYS GLU LYS          
SEQRES  25 U  324  SER ASP VAL LYS LYS GLU GLU LYS LYS GLU LYS LYS              
SEQRES   1 O  376  MET LYS ASP VAL PRO GLY PHE LEU GLN GLN SER GLN ASN          
SEQRES   2 O  376  SER GLY PRO GLY GLN PRO ALA VAL TRP HIS ARG LEU GLU          
SEQRES   3 O  376  GLU LEU TYR THR LYS LYS LEU TRP HIS GLN LEU THR LEU          
SEQRES   4 O  376  GLN VAL LEU ASP PHE VAL GLN ASP PRO CYS PHE ALA GLN          
SEQRES   5 O  376  GLY ASP GLY LEU ILE LYS LEU TYR GLU ASN PHE ILE SER          
SEQRES   6 O  376  GLU PHE GLU HIS ARG VAL ASN PRO LEU SER LEU VAL GLU          
SEQRES   7 O  376  ILE ILE LEU HIS VAL VAL ARG GLN MET THR ASP PRO ASN          
SEQRES   8 O  376  VAL ALA LEU THR PHE LEU GLU LYS THR ARG GLU LYS VAL          
SEQRES   9 O  376  LYS SER SER ASP GLU ALA VAL ILE LEU CYS LYS THR ALA          
SEQRES  10 O  376  ILE GLY ALA LEU LYS LEU ASN ILE GLY ASP LEU GLN VAL          
SEQRES  11 O  376  THR LYS GLU THR ILE GLU ASP VAL GLU GLU MET LEU ASN          
SEQRES  12 O  376  ASN LEU PRO GLY VAL THR SER VAL HIS SER ARG PHE TYR          
SEQRES  13 O  376  ASP LEU SER SER LYS TYR TYR GLN THR ILE GLY ASN HIS          
SEQRES  14 O  376  ALA SER TYR TYR LYS ASP ALA LEU ARG PHE LEU GLY CYS          
SEQRES  15 O  376  VAL ASP ILE LYS ASP LEU PRO VAL SER GLU GLN GLN GLU          
SEQRES  16 O  376  ARG ALA PHE THR LEU GLY LEU ALA GLY LEU LEU GLY GLU          
SEQRES  17 O  376  GLY VAL PHE ASN PHE GLY GLU LEU LEU MET HIS PRO VAL          
SEQRES  18 O  376  LEU GLU SER LEU ARG ASN THR ASP ARG GLN TRP LEU ILE          
SEQRES  19 O  376  ASP THR LEU TYR ALA PHE ASN SER GLY ASN VAL GLU ARG          
SEQRES  20 O  376  PHE GLN THR LEU LYS THR ALA TRP GLY GLN GLN PRO ASP          
SEQRES  21 O  376  LEU ALA ALA ASN GLU ALA GLN LEU LEU ARG LYS ILE GLN          
SEQRES  22 O  376  LEU LEU CYS LEU MET GLU MET THR PHE THR ARG PRO ALA          
SEQRES  23 O  376  ASN HIS ARG GLN LEU THR PHE GLU GLU ILE ALA LYS SER          
SEQRES  24 O  376  ALA LYS ILE THR VAL ASN GLU VAL GLU LEU LEU VAL MET          
SEQRES  25 O  376  LYS ALA LEU SER VAL GLY LEU VAL LYS GLY SER ILE ASP          
SEQRES  26 O  376  GLU VAL ASP LYS ARG VAL HIS MET THR TRP VAL GLN PRO          
SEQRES  27 O  376  ARG VAL LEU ASP LEU GLN GLN ILE LYS GLY MET LYS ASP          
SEQRES  28 O  376  ARG LEU GLU PHE TRP CYS THR ASP VAL LYS SER MET GLU          
SEQRES  29 O  376  MET LEU VAL GLU HIS GLN ALA HIS ASP ILE LEU THR              
HELIX    1 AA1 SER W   13  ARG W   17  5                                   5    
HELIX    2 AA2 THR W   24  SER W   39  1                                  16    
HELIX    3 AA3 ASP W   67  HIS W   76  1                                  10    
HELIX    4 AA4 PHE W   86  HIS W   99  1                                  14    
HELIX    5 AA5 ASN W  120  LYS W  135  1                                  16    
HELIX    6 AA6 GLU W  151  ASN W  158  1                                   8    
HELIX    7 AA7 SER V   35  ALA V   47  1                                  13    
HELIX    8 AA8 ASP V   88  GLN V  101  1                                  14    
HELIX    9 AA9 SER V  123  SER V  137  1                                  15    
HELIX   10 AB1 ASN V  164  LEU V  170  1                                   7    
HELIX   11 AB2 HIS V  172  GLN V  176  5                                   5    
HELIX   12 AB3 SER V  188  ILE V  193  1                                   6    
HELIX   13 AB4 ASN V  210  LEU V  218  1                                   9    
HELIX   14 AB5 HIS V  237  LYS V  264  1                                  28    
HELIX   15 AB6 THR V  266  ILE V  272  1                                   7    
HELIX   16 AB7 PRO V  280  PHE V  309  1                                  30    
HELIX   17 AB8 PRO T   80  GLU T   96  1                                  17    
HELIX   18 AB9 GLU T   96  GLU T  101  1                                   6    
HELIX   19 AC1 SER T  110  GLU T  115  1                                   6    
HELIX   20 AC2 LEU T  119  LEU T  124  1                                   6    
HELIX   21 AC3 GLU T  125  ASN T  127  5                                   3    
HELIX   22 AC4 THR T  134  GLN T  140  1                                   7    
HELIX   23 AC5 LEU T  141  LYS T  159  1                                  19    
HELIX   24 AC6 ASP T  160  TYR T  174  1                                  15    
HELIX   25 AC7 PHE T  176  GLN T  181  1                                   6    
HELIX   26 AC8 GLN T  190  GLN T  202  1                                  13    
HELIX   27 AC9 ARG T  204  GLU T  213  1                                  10    
HELIX   28 AD1 PRO T  216  ILE T  220  5                                   5    
HELIX   29 AD2 ILE T  226  GLU T  238  1                                  13    
HELIX   30 AD3 VAL T  244  LYS T  248  5                                   5    
HELIX   31 AD4 ALA T  253  ILE T  260  1                                   8    
HELIX   32 AD5 LEU T  263  TYR T  279  1                                  17    
HELIX   33 AD6 PHE T  284  LEU T  291  1                                   8    
HELIX   34 AD7 THR T  295  ARG T  306  1                                  12    
HELIX   35 AD8 SER T  332  MET T  348  1                                  17    
HELIX   36 AD9 ASP Y   51  HIS Y   63  1                                  13    
HELIX   37 AE1 VAL Z   11  SER Z   16  1                                   6    
HELIX   38 AE2 ALA Z   19  ASP Z   25  1                                   7    
HELIX   39 AE3 GLU Z   44  LYS Z   50  1                                   7    
HELIX   40 AE4 GLN Z   51  LEU Z   56  1                                   6    
HELIX   41 AE5 VAL Z   60  GLU Z   65  1                                   6    
HELIX   42 AE6 ASP Z   67  ARG Z   72  1                                   6    
HELIX   43 AE7 ARG Z   72  GLN Z   81  1                                  10    
HELIX   44 AE8 LYS Z   94  LEU Z   99  1                                   6    
HELIX   45 AE9 LEU Z  106  GLU Z  111  1                                   6    
HELIX   46 AF1 ARG Z  120  VAL Z  128  1                                   9    
HELIX   47 AF2 THR Z  132  ARG Z  143  1                                  12    
HELIX   48 AF3 VAL Z  166  TRP Z  170  5                                   5    
HELIX   49 AF4 ALA Z  176  ARG Z  181  1                                   6    
HELIX   50 AF5 LEU Z  187  GLU Z  190  5                                   4    
HELIX   51 AF6 ILE Z  191  ALA Z  197  1                                   7    
HELIX   52 AF7 GLU Z  201  MET Z  216  1                                  16    
HELIX   53 AF8 TYR Z  226  VAL Z  237  1                                  12    
HELIX   54 AF9 PRO Z  241  ALA Z  252  1                                  12    
HELIX   55 AG1 LEU Z  253  PHE Z  259  1                                   7    
HELIX   56 AG2 PHE Z  262  ASN Z  273  1                                  12    
HELIX   57 AG3 ASP Z  274  CYS Z  285  1                                  12    
HELIX   58 AG4 LYS Z  292  ASP Z  310  1                                  19    
HELIX   59 AG5 ASP Z  316  ASN Z  329  1                                  14    
HELIX   60 AG6 ALA Z  332  GLU Z  341  1                                  10    
HELIX   61 AG7 VAL Z  344  ARG Z  357  1                                  14    
HELIX   62 AG8 ARG Z  369  ASN Z  382  1                                  14    
HELIX   63 AG9 LYS Z  389  ASP Z  394  1                                   6    
HELIX   64 AH1 GLY Z  395  TYR Z  400  1                                   6    
HELIX   65 AH2 LYS Z  403  GLY Z  406  5                                   4    
HELIX   66 AH3 MET Z  407  LEU Z  418  1                                  12    
HELIX   67 AH4 GLY Z  425  TYR Z  434  1                                  10    
HELIX   68 AH5 TYR Z  439  SER Z  453  1                                  15    
HELIX   69 AH6 PRO Z  461  LEU Z  465  5                                   5    
HELIX   70 AH7 LEU Z  466  LEU Z  471  1                                   6    
HELIX   71 AH8 THR Z  476  TYR Z  489  1                                  14    
HELIX   72 AH9 ARG Z  494  THR Z  499  1                                   6    
HELIX   73 AI1 LEU Z  501  SER Z  508  1                                   8    
HELIX   74 AI2 VAL Z  517  VAL Z  527  1                                  11    
HELIX   75 AI3 VAL Z  534  LYS Z  545  1                                  12    
HELIX   76 AI4 LYS Z  551  HIS Z  566  1                                  16    
HELIX   77 AI5 ALA Z  575  LEU Z  580  1                                   6    
HELIX   78 AI6 PHE Z  587  CYS Z  598  1                                  12    
HELIX   79 AI7 LEU Z  607  ILE Z  615  1                                   9    
HELIX   80 AI8 CYS Z  616  GLU Z  618  5                                   3    
HELIX   81 AI9 LYS Z  625  LYS Z  640  1                                  16    
HELIX   82 AJ1 ASP Z  645  LEU Z  659  1                                  15    
HELIX   83 AJ2 LEU Z  659  GLU Z  664  1                                   6    
HELIX   84 AJ3 ILE Z  666  GLU Z  683  1                                  18    
HELIX   85 AJ4 ARG Z  688  SER Z  698  1                                  11    
HELIX   86 AJ5 VAL Z  699  ASN Z  701  5                                   3    
HELIX   87 AJ6 LEU Z  704  HIS Z  715  1                                  12    
HELIX   88 AJ7 VAL Z  721  THR Z  736  1                                  16    
HELIX   89 AJ8 ALA Z  742  LYS Z  754  1                                  13    
HELIX   90 AJ9 ASP Z  755  LEU Z  759  5                                   5    
HELIX   91 AK1 GLY Z  774  GLN Z  786  1                                  13    
HELIX   92 AK2 GLN Z  790  GLY Z  795  1                                   6    
HELIX   93 AK3 ALA N    5  SER N   10  1                                   6    
HELIX   94 AK4 GLU N   16  PHE N   22  1                                   7    
HELIX   95 AK5 PHE N   22  LEU N   27  1                                   6    
HELIX   96 AK6 PHE N   34  SER N   39  1                                   6    
HELIX   97 AK7 VAL N   42  ASP N   51  1                                  10    
HELIX   98 AK8 SER N   56  LEU N   71  1                                  16    
HELIX   99 AK9 GLU N   75  LEU N   82  1                                   8    
HELIX  100 AL1 GLY N   83  GLY N   85  5                                   3    
HELIX  101 AL2 SER N   94  LEU N  118  1                                  25    
HELIX  102 AL3 ASP N  127  ASP N  144  1                                  18    
HELIX  103 AL4 LYS N  146  THR N  157  1                                  12    
HELIX  104 AL5 ARG N  159  GLU N  169  1                                  11    
HELIX  105 AL6 ASP N  172  SER N  186  1                                  15    
HELIX  106 AL7 ASN N  190  ILE N  204  1                                  15    
HELIX  107 AL8 ASP N  212  ASP N  224  1                                  13    
HELIX  108 AL9 ASP N  225  GLU N  234  1                                  10    
HELIX  109 AM1 ASN N  241  ALA N  256  1                                  16    
HELIX  110 AM2 SER N  257  THR N  273  1                                  17    
HELIX  111 AM3 GLY N  331  ASN N  345  1                                  15    
HELIX  112 AM4 MET N  351  VAL N  360  1                                  10    
HELIX  113 AM5 VAL N  364  HIS N  377  1                                  14    
HELIX  114 AM6 ASP N  383  ASP N  388  1                                   6    
HELIX  115 AM7 LEU N  390  ALA N  396  1                                   7    
HELIX  116 AM8 GLU N  418  MET N  423  1                                   6    
HELIX  117 AM9 ALA N  424  TYR N  426  5                                   3    
HELIX  118 AN1 SER N  435  HIS N  450  1                                  16    
HELIX  119 AN2 GLY N  455  ASN N  467  1                                  13    
HELIX  120 AN3 ASN N  470  ALA N  485  1                                  16    
HELIX  121 AN4 ARG N  490  TYR N  502  1                                  13    
HELIX  122 AN5 ASP N  505  MET N  520  1                                  16    
HELIX  123 AN6 ASN N  525  THR N  539  1                                  15    
HELIX  124 AN7 LYS N  543  LEU N  554  1                                  12    
HELIX  125 AN8 LEU N  566  CYS N  571  1                                   6    
HELIX  126 AN9 PRO N  576  TYR N  590  1                                  15    
HELIX  127 AO1 ASN N  596  ARG N  601  1                                   6    
HELIX  128 AO2 VAL N  614  SER N  621  1                                   8    
HELIX  129 AO3 SER N  621  LEU N  626  1                                   6    
HELIX  130 AO4 GLN N  632  VAL N  636  5                                   5    
HELIX  131 AO5 VAL N  637  GLU N  642  1                                   6    
HELIX  132 AO6 ASN N  645  CYS N  660  1                                  16    
HELIX  133 AO7 ASN N  665  ASN N  677  1                                  13    
HELIX  134 AO8 VAL N  680  MET N  695  1                                  16    
HELIX  135 AO9 LYS N  705  VAL N  716  1                                  12    
HELIX  136 AP1 ASP N  723  ILE N  736  1                                  14    
HELIX  137 AP2 ASP N  738  ASN N  743  1                                   6    
HELIX  138 AP3 HIS N  756  GLN N  768  1                                  13    
HELIX  139 AP4 HIS N  777  LEU N  781  5                                   5    
HELIX  140 AP5 LYS N  807  ALA N  812  1                                   6    
HELIX  141 AP6 VAL N  819  GLU N  852  1                                  34    
HELIX  142 AP7 MET N  885  LYS N  890  1                                   6    
HELIX  143 AP8 LYS N  934  GLN N  940  1                                   7    
HELIX  144 AP9 LYS S   54  ILE S   75  1                                  22    
HELIX  145 AQ1 GLU S   77  ALA S   85  1                                   9    
HELIX  146 AQ2 LYS S   89  VAL S   94  1                                   6    
HELIX  147 AQ3 LEU S   95  ARG S   99  5                                   5    
HELIX  148 AQ4 PRO S  102  ARG S  107  5                                   6    
HELIX  149 AQ5 THR S  127  LEU S  132  1                                   6    
HELIX  150 AQ6 LEU S  159  SER S  178  1                                  20    
HELIX  151 AQ7 TYR S  181  SER S  196  1                                  16    
HELIX  152 AQ8 ALA S  202  LYS S  223  1                                  22    
HELIX  153 AQ9 ASP S  225  HIS S  242  1                                  18    
HELIX  154 AR1 ASP S  243  TYR S  261  1                                  19    
HELIX  155 AR2 LEU S  263  SER S  274  1                                  12    
HELIX  156 AR3 ASN S  281  GLN S  299  1                                  19    
HELIX  157 AR4 GLU S  301  ARG S  314  1                                  14    
HELIX  158 AR5 ALA S  321  GLY S  340  1                                  20    
HELIX  159 AR6 ASP S  344  ARG S  349  5                                   6    
HELIX  160 AR7 PRO S  351  ARG S  355  5                                   5    
HELIX  161 AR8 LEU S  357  GLY S  370  1                                  14    
HELIX  162 AR9 ASN S  371  PHE S  382  1                                  12    
HELIX  163 AS1 PHE S  382  GLN S  387  1                                   6    
HELIX  164 AS2 THR S  391  ILE S  396  1                                   6    
HELIX  165 AS3 LEU S  398  SER S  413  1                                  16    
HELIX  166 AS4 LEU S  419  LEU S  426  1                                   8    
HELIX  167 AS5 SER S  430  ASP S  444  1                                  15    
HELIX  168 AS6 ARG S  470  ARG S  495  1                                  26    
HELIX  169 AS7 ARG S  495  ASP S  504  1                                  10    
HELIX  170 AS8 GLU S  509  SER S  532  1                                  24    
HELIX  171 AS9 GLY P    5  GLY P   11  1                                   7    
HELIX  172 AT1 GLY P   11  TYR P   20  1                                  10    
HELIX  173 AT2 TYR P   20  ALA P   35  1                                  16    
HELIX  174 AT3 LEU P   40  GLU P   51  1                                  12    
HELIX  175 AT4 THR P   54  MET P   60  1                                   7    
HELIX  176 AT5 MET P   60  LYS P   72  1                                  13    
HELIX  177 AT6 GLU P   76  ASP P   81  1                                   6    
HELIX  178 AT7 LEU P   82  ARG P   93  1                                  12    
HELIX  179 AT8 LEU P   97  GLU P  113  1                                  17    
HELIX  180 AT9 ASP P  117  ILE P  120  5                                   4    
HELIX  181 AU1 LYS P  121  MET P  130  1                                  10    
HELIX  182 AU2 TYR P  137  ALA P  150  1                                  14    
HELIX  183 AU3 GLU P  161  LEU P  166  1                                   6    
HELIX  184 AU4 GLU P  178  VAL P  196  1                                  19    
HELIX  185 AU5 ASP P  198  SER P  206  1                                   9    
HELIX  186 AU6 LYS P  207  ILE P  209  5                                   3    
HELIX  187 AU7 THR P  211  GLU P  216  5                                   6    
HELIX  188 AU8 THR P  219  GLY P  238  1                                  20    
HELIX  189 AU9 SER P  239  TYR P  251  1                                  13    
HELIX  190 AV1 THR P  253  ALA P  258  1                                   6    
HELIX  191 AV2 GLU P  259  ALA P  277  1                                  19    
HELIX  192 AV3 ASN P  281  ILE P  290  1                                  10    
HELIX  193 AV4 LYS P  294  GLU P  298  5                                   5    
HELIX  194 AV5 ILE P  299  THR P  311  1                                  13    
HELIX  195 AV6 ARG P  316  ASP P  323  1                                   8    
HELIX  196 AV7 GLU P  346  TYR P  370  1                                  25    
HELIX  197 AV8 MET P  375  LEU P  381  1                                   7    
HELIX  198 AV9 ASP P  387  PHE P  392  1                                   6    
HELIX  199 AW1 ASP P  420  ASN P  454  1                                  35    
HELIX  200 AW2 ALA Q    5  GLN Q   10  1                                   6    
HELIX  201 AW3 GLN Q   13  ASP Q   19  1                                   7    
HELIX  202 AW4 SER Q   23  VAL Q   31  1                                   9    
HELIX  203 AW5 GLU Q   47  ALA Q   58  1                                  12    
HELIX  204 AW6 ALA Q   63  GLY Q   68  1                                   6    
HELIX  205 AW7 LEU Q   69  ARG Q   74  5                                   6    
HELIX  206 AW8 ALA Q   83  ASP Q   98  1                                  16    
HELIX  207 AW9 GLN Q  105  ALA Q  117  1                                  13    
HELIX  208 AX1 THR Q  123  TYR Q  137  1                                  15    
HELIX  209 AX2 ARG Q  142  GLY Q  150  1                                   9    
HELIX  210 AX3 ASP Q  161  LEU Q  165  5                                   5    
HELIX  211 AX4 VAL Q  167  LEU Q  180  1                                  14    
HELIX  212 AX5 LYS Q  185  ALA Q  197  1                                  13    
HELIX  213 AX6 PRO Q  203  ALA Q  220  1                                  18    
HELIX  214 AX7 ASP Q  224  ILE Q  242  1                                  19    
HELIX  215 AX8 PRO Q  245  MET Q  260  1                                  16    
HELIX  216 AX9 LEU Q  261  THR Q  263  5                                   3    
HELIX  217 AY1 PRO Q  264  VAL Q  271  1                                   8    
HELIX  218 AY2 ALA Q  276  ALA Q  280  5                                   5    
HELIX  219 AY3 GLY Q  281  ARG Q  297  1                                  17    
HELIX  220 AY4 SER Q  298  TYR Q  309  1                                  12    
HELIX  221 AY5 ALA Q  311  ASP Q  316  1                                   6    
HELIX  222 AY6 ILE Q  318  GLU Q  340  1                                  23    
HELIX  223 AY7 ILE Q  347  LYS Q  355  1                                   9    
HELIX  224 AY8 SER Q  357  ASP Q  371  1                                  15    
HELIX  225 AY9 ASP Q  394  THR Q  422  1                                  29    
HELIX  226 AZ1 ARG R   18  LEU R   26  1                                   9    
HELIX  227 AZ2 GLY R   33  ASP R   47  1                                  15    
HELIX  228 AZ3 ASP R   66  GLU R   92  1                                  27    
HELIX  229 AZ4 GLY R   96  LEU R  111  1                                  16    
HELIX  230 AZ5 ASP R  116  ASP R  129  1                                  14    
HELIX  231 AZ6 ALA R  133  TYR R  151  1                                  19    
HELIX  232 AZ7 ASP R  153  GLY R  172  1                                  20    
HELIX  233 AZ8 ASP R  173  ILE R  191  1                                  19    
HELIX  234 AZ9 PHE R  194  THR R  204  1                                  11    
HELIX  235 BA1 TYR R  216  LEU R  231  1                                  16    
HELIX  236 BA2 ASP R  235  VAL R  240  1                                   6    
HELIX  237 BA3 ALA R  244  HIS R  251  1                                   8    
HELIX  238 BA4 LEU R  253  CYS R  266  1                                  14    
HELIX  239 BA5 ARG R  267  LYS R  283  1                                  17    
HELIX  240 BA6 HIS R  291  LEU R  307  1                                  17    
HELIX  241 BA7 THR R  315  PHE R  323  1                                   9    
HELIX  242 BA8 GLY R  326  ALA R  340  1                                  15    
HELIX  243 BA9 ASP R  360  TRP R  364  5                                   5    
HELIX  244 BB1 TYR R  366  MET R  389  1                                  24    
HELIX  245 BB2 HIS U   12  ILE U   26  1                                  15    
HELIX  246 BB3 ASP U   71  LYS U   84  1                                  14    
HELIX  247 BB4 ASN U  104  ARG U  114  1                                  11    
HELIX  248 BB5 GLU U  165  LEU U  176  1                                  12    
HELIX  249 BB6 GLY U  185  THR U  217  1                                  33    
HELIX  250 BB7 ASN U  223  LEU U  237  1                                  15    
HELIX  251 BB8 SER U  241  GLY U  290  1                                  50    
HELIX  252 BB9 LYS O    2  GLN O    9  1                                   8    
HELIX  253 BC1 GLY O   17  LYS O   32  1                                  16    
HELIX  254 BC2 LEU O   33  VAL O   45  1                                  13    
HELIX  255 BC3 ILE O   57  ASN O   62  1                                   6    
HELIX  256 BC4 ASN O   72  MET O   87  1                                  16    
HELIX  257 BC5 ASN O   91  LYS O  105  1                                  15    
HELIX  258 BC6 VAL O  111  GLY O  126  1                                  16    
HELIX  259 BC7 ASP O  127  ASN O  144  1                                  18    
HELIX  260 BC8 VAL O  151  GLY O  167  1                                  17    
HELIX  261 BC9 ASN O  168  GLY O  181  1                                  14    
HELIX  262 BD1 PRO O  189  GLY O  207  1                                  19    
HELIX  263 BD2 ASN O  212  LEU O  217  1                                   6    
HELIX  264 BD3 ARG O  230  GLY O  243  1                                  14    
HELIX  265 BD4 ASN O  244  THR O  250  1                                   7    
HELIX  266 BD5 GLN O  258  ASN O  264  1                                   7    
HELIX  267 BD6 LEU O  269  ARG O  284  1                                  16    
HELIX  268 BD7 PHE O  293  LYS O  301  1                                   9    
HELIX  269 BD8 GLU O  306  GLY O  318  1                                  13    
HELIX  270 BD9 ASP O  342  HIS O  369  1                                  28    
HELIX  271 BE1 GLN O  370  THR O  376  1                                   7    
SHEET    1 AA1 6 VAL W  60  THR W  65  0                                        
SHEET    2 AA1 6 ASN W  48  THR W  53 -1  N  VAL W  49   O  THR W  65           
SHEET    3 AA1 6 GLU W   4  VAL W  10  1  N  THR W   6   O  ASN W  48           
SHEET    4 AA1 6 LYS W 106  VAL W 113  1  O  PHE W 112   N  CYS W   9           
SHEET    5 AA1 6 VAL W 136  PHE W 143  1  O  ILE W 141   N  ALA W 111           
SHEET    6 AA1 6 LEU W 170  VAL W 173  1  O  VAL W 171   N  ASN W 142           
SHEET    1 AA2 8 TYR V 200  SER V 202  0                                        
SHEET    2 AA2 8 ILE V 157  LEU V 162 -1  N  ARG V 161   O  TYR V 201           
SHEET    3 AA2 8 VAL V 141  VAL V 145 -1  N  ALA V 142   O  PHE V 160           
SHEET    4 AA2 8 MET V 107  SER V 114  1  N  HIS V 113   O  VAL V 143           
SHEET    5 AA2 8 MET V  54  VAL V  62 -1  N  MET V  57   O  VAL V 109           
SHEET    6 AA2 8 THR V  66  ALA V  74 -1  O  ASP V  71   N  LEU V  58           
SHEET    7 AA2 8 GLN V  30  SER V  34  1  N  TYR V  32   O  VAL V  67           
SHEET    8 AA2 8 THR V 204  ARG V 208  1  O  ASN V 206   N  VAL V  31           
SHEET    1 AA3 3 LYS T 281  LEU T 283  0                                        
SHEET    2 AA3 3 ASN T 313  TYR T 315 -1  O  ASN T 314   N  ILE T 282           
SHEET    3 AA3 3 VAL T 309  LEU T 310 -1  N  VAL T 309   O  TYR T 315           
SHEET    1 AA4 3 ILE Z 810  LEU Z 811  0                                        
SHEET    2 AA4 3 LEU Z 882  GLU Z 886  1  O  THR Z 884   N  LEU Z 811           
SHEET    3 AA4 3 THR Z 869  LEU Z 873 -1  N  THR Z 870   O  GLU Z 885           
SHEET    1 AA5 3 ARG Z 845  VAL Z 846  0                                        
SHEET    2 AA5 3 ALA Z 823  ALA Z 824 -1  N  ALA Z 823   O  VAL Z 846           
SHEET    3 AA5 3 THR Z 861  ILE Z 862 -1  O  THR Z 861   N  ALA Z 824           
SHEET    1 AA6 2 THR N 745  ILE N 746  0                                        
SHEET    2 AA6 2 TYR N 783  THR N 784 -1  O  THR N 784   N  THR N 745           
SHEET    1 AA7 2 GLN N 749  SER N 750  0                                        
SHEET    2 AA7 2 HIS N 754  THR N 755 -1  O  HIS N 754   N  SER N 750           
SHEET    1 AA8 3 PRO N 881  ARG N 883  0                                        
SHEET    2 AA8 3 CYS N 787  LEU N 791 -1  N  VAL N 788   O  ALA N 882           
SHEET    3 AA8 3 GLY N 910  ILE N 913  1  O  ILE N 912   N  LEU N 791           
SHEET    1 AA9 2 LYS N 803  SER N 804  0                                        
SHEET    2 AA9 2 LEU N 892  THR N 893 -1  O  THR N 893   N  LYS N 803           
SHEET    1 AB1 4 ALA S 449  ASN S 452  0                                        
SHEET    2 AB1 4 TYR S 457  SER S 460 -1  O  GLN S 459   N  SER S 450           
SHEET    3 AB1 4 TYR S 414  SER S 418 -1  N  SER S 415   O  SER S 460           
SHEET    4 AB1 4 ILE R 347  ASP R 348  1  O  ILE R 347   N  SER S 415           
SHEET    1 AB2 3 ARG P 372  THR P 374  0                                        
SHEET    2 AB2 3 ILE P 412  ASN P 414 -1  O  ILE P 413   N  ILE P 373           
SHEET    3 AB2 3 LYS P 405  ASP P 407 -1  N  LYS P 405   O  ASN P 414           
SHEET    1 AB3 3 VAL Q 345  GLN Q 346  0                                        
SHEET    2 AB3 3 VAL Q 384  ILE Q 386 -1  O  LEU Q 385   N  VAL Q 345           
SHEET    3 AB3 3 ILE Q 377  LEU Q 378 -1  N  ILE Q 377   O  ILE Q 386           
SHEET    1 AB4 8 GLU U 156  VAL U 158  0                                        
SHEET    2 AB4 8 THR U 135  ILE U 139 -1  N  ALA U 137   O  VAL U 158           
SHEET    3 AB4 8 VAL U 120  ILE U 124 -1  N  ILE U 123   O  GLU U 136           
SHEET    4 AB4 8 ARG U  90  HIS U  96  1  N  TRP U  94   O  VAL U 120           
SHEET    5 AB4 8 VAL U  36  SER U  42 -1  N  LEU U  39   O  GLY U  93           
SHEET    6 AB4 8 VAL U  47  ALA U  55 -1  O  ASN U  52   N  LEU U  40           
SHEET    7 AB4 8 LYS U   8  VAL U  11  1  N  VAL U  10   O  VAL U  50           
SHEET    8 AB4 8 SER U 160  ILE U 162  1  O  GLU U 161   N  VAL U   9           
SHEET    1 AB5 2 PHE U  58  GLU U  60  0                                        
SHEET    2 AB5 2 TRP U  68  LEU U  70 -1  O  PHE U  69   N  ASP U  59           
SHEET    1 AB6 2 GLU U 142  GLU U 143  0                                        
SHEET    2 AB6 2 SER U 152  LYS U 153 -1  O  SER U 152   N  GLU U 143           
SHEET    1 AB7 3 GLN O 290  THR O 292  0                                        
SHEET    2 AB7 3 ARG O 330  VAL O 336 -1  O  VAL O 331   N  LEU O 291           
SHEET    3 AB7 3 VAL O 320  ASP O 325 -1  N  SER O 323   O  HIS O 332           
CISPEP   1 GLU N  872    PRO N  873          0         3.58                     
CISPEP   2 GLY U   98    PRO U   99          0         3.51                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.001929  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.001929  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.001929        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system