GenomeNet

Database: PDB
Entry: 5L9U
LinkDB: 5L9U
Original site: 5L9U 
HEADER    SIGNALING PROTEIN                       11-JUN-16   5L9U              
TITLE     MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC/C-CDH1) WITH 
TITLE    2 A CROSS LINKED UBIQUITIN VARIANT-SUBSTRATE-UBE2C (UBCH10) COMPLEX    
TITLE    3 REPRESENTING KEY FEATURES OF MULTIUBIQUITINATION                     
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1;                      
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: APC1,CYCLOSOME SUBUNIT 1,MITOTIC CHECKPOINT REGULATOR,      
COMPND   5 TESTIS-SPECIFIC GENE 24 PROTEIN;                                     
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 11;                     
COMPND   9 CHAIN: B;                                                            
COMPND  10 SYNONYM: APC11,CYCLOSOME SUBUNIT 11,HEPATOCELLULAR CARCINOMA-        
COMPND  11 ASSOCIATED RING FINGER PROTEIN;                                      
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: CELL DIVISION CYCLE PROTEIN 23 HOMOLOG;                    
COMPND  15 CHAIN: C, P;                                                         
COMPND  16 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 8,APC8,CYCLOSOME SUBUNIT 
COMPND  17 8;                                                                   
COMPND  18 ENGINEERED: YES;                                                     
COMPND  19 MOL_ID: 4;                                                           
COMPND  20 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 15;                     
COMPND  21 CHAIN: D;                                                            
COMPND  22 SYNONYM: APC15;                                                      
COMPND  23 ENGINEERED: YES;                                                     
COMPND  24 MOL_ID: 5;                                                           
COMPND  25 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 16;                     
COMPND  26 CHAIN: E;                                                            
COMPND  27 SYNONYM: APC16,CYCLOSOME SUBUNIT 16;                                 
COMPND  28 ENGINEERED: YES;                                                     
COMPND  29 MOL_ID: 6;                                                           
COMPND  30 MOLECULE: CELL DIVISION CYCLE PROTEIN 27 HOMOLOG;                    
COMPND  31 CHAIN: F, H;                                                         
COMPND  32 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 3,APC3,CDC27 HOMOLOG,    
COMPND  33 CDC27HS,H-NUC;                                                       
COMPND  34 ENGINEERED: YES;                                                     
COMPND  35 MOL_ID: 7;                                                           
COMPND  36 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26;                  
COMPND  37 CHAIN: G, W;                                                         
COMPND  38 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 12,APC12,CELL DIVISION   
COMPND  39 CYCLE PROTEIN 26 HOMOLOG;                                            
COMPND  40 ENGINEERED: YES;                                                     
COMPND  41 MOL_ID: 8;                                                           
COMPND  42 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 4;                      
COMPND  43 CHAIN: I;                                                            
COMPND  44 SYNONYM: APC4,CYCLOSOME SUBUNIT 4;                                   
COMPND  45 ENGINEERED: YES;                                                     
COMPND  46 OTHER_DETAILS: CONSTRUCT CONTAINS THE REMNANT OF PRESCISSION PROTEASE
COMPND  47 SITE AT C-TERMINUS.;                                                 
COMPND  48 MOL_ID: 9;                                                           
COMPND  49 MOLECULE: CELL DIVISION CYCLE PROTEIN 16 HOMOLOG;                    
COMPND  50 CHAIN: J, K;                                                         
COMPND  51 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 6,APC6,CDC16 HOMOLOG,    
COMPND  52 CDC16HS,CYCLOSOME SUBUNIT 6;                                         
COMPND  53 ENGINEERED: YES;                                                     
COMPND  54 MOL_ID: 10;                                                          
COMPND  55 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 10;                     
COMPND  56 CHAIN: L;                                                            
COMPND  57 SYNONYM: APC10,CYCLOSOME SUBUNIT 10;                                 
COMPND  58 ENGINEERED: YES;                                                     
COMPND  59 MOL_ID: 11;                                                          
COMPND  60 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 13;                     
COMPND  61 CHAIN: M;                                                            
COMPND  62 SYNONYM: APC13,CYCLOSOME SUBUNIT 13;                                 
COMPND  63 ENGINEERED: YES;                                                     
COMPND  64 MOL_ID: 12;                                                          
COMPND  65 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 2;                      
COMPND  66 CHAIN: N;                                                            
COMPND  67 SYNONYM: APC2,CYCLOSOME SUBUNIT 2;                                   
COMPND  68 ENGINEERED: YES;                                                     
COMPND  69 MOL_ID: 13;                                                          
COMPND  70 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 5;                      
COMPND  71 CHAIN: O;                                                            
COMPND  72 SYNONYM: APC5,CYCLOSOME SUBUNIT 5;                                   
COMPND  73 ENGINEERED: YES;                                                     
COMPND  74 MOL_ID: 14;                                                          
COMPND  75 MOLECULE: FIZZY-RELATED PROTEIN HOMOLOG;                             
COMPND  76 CHAIN: R;                                                            
COMPND  77 SYNONYM: FZR,CDC20-LIKE PROTEIN 1,CDH1/HCT1 HOMOLOG,HCDH1;           
COMPND  78 ENGINEERED: YES;                                                     
COMPND  79 MOL_ID: 15;                                                          
COMPND  80 MOLECULE: HSL1(SUBSTRATE)_PEPTIDE-UBIQUITIN_VARIANT FUSION;          
COMPND  81 CHAIN: S;                                                            
COMPND  82 EC: 2.7.11.1;                                                        
COMPND  83 ENGINEERED: YES;                                                     
COMPND  84 MUTATION: YES;                                                       
COMPND  85 OTHER_DETAILS: THIS CONSTRUCT COMPRISES 768-842 OF HSL1 WITH AN N-   
COMPND  86 TERMINAL GEMINI-IM MOTIF AND LINKER AND A C-TERMINAL UB VARIANT      
COMPND  87 (CHAIN V). K788C OF THIS CONSTRUCT IS CROSS-LINKED TO UBE2C C115     
COMPND  88 (CHAIN U) AND TO UBG75C (NOT VISIBLE) VIA TMEA.;                     
COMPND  89 MOL_ID: 16;                                                          
COMPND  90 MOLECULE: UBIQUITIN-CONJUGATING ENZYME E2 C;                         
COMPND  91 CHAIN: U;                                                            
COMPND  92 SYNONYM: (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME C,E2       
COMPND  93 UBIQUITIN-CONJUGATING ENZYME C,UBCH10,UBIQUITIN CARRIER PROTEIN C,   
COMPND  94 UBIQUITIN-PROTEIN LIGASE C;                                          
COMPND  95 EC: 2.3.2.23,2.3.2.24;                                               
COMPND  96 ENGINEERED: YES;                                                     
COMPND  97 MUTATION: YES;                                                       
COMPND  98 MOL_ID: 17;                                                          
COMPND  99 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 7;                      
COMPND 100 CHAIN: X, Y;                                                         
COMPND 101 SYNONYM: APC7,CYCLOSOME SUBUNIT 7;                                   
COMPND 102 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: ANAPC1, TSG24;                                                 
SOURCE   6 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE   7 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 GENE: ANAPC11, HSPC214;                                              
SOURCE  14 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  15 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  17 MOL_ID: 3;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 GENE: CDC23, ANAPC8;                                                 
SOURCE  22 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  23 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  24 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  25 MOL_ID: 4;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 GENE: ANAPC15, C11ORF51, HSPC020;                                    
SOURCE  30 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  31 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  32 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  33 MOL_ID: 5;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  35 ORGANISM_COMMON: HUMAN;                                              
SOURCE  36 ORGANISM_TAXID: 9606;                                                
SOURCE  37 GENE: ANAPC16, C10ORF104, CENP-27;                                   
SOURCE  38 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  39 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  40 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  41 MOL_ID: 6;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 GENE: CDC27, ANAPC3, D0S1430E, D17S978E;                             
SOURCE  46 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  47 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  48 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  49 MOL_ID: 7;                                                           
SOURCE  50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  51 ORGANISM_COMMON: HUMAN;                                              
SOURCE  52 ORGANISM_TAXID: 9606;                                                
SOURCE  53 GENE: CDC26, ANAPC12, C9ORF17;                                       
SOURCE  54 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  55 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  56 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  57 MOL_ID: 8;                                                           
SOURCE  58 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  59 ORGANISM_COMMON: HUMAN;                                              
SOURCE  60 ORGANISM_TAXID: 9606;                                                
SOURCE  61 GENE: ANAPC4, APC4;                                                  
SOURCE  62 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  63 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  64 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  65 MOL_ID: 9;                                                           
SOURCE  66 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  67 ORGANISM_COMMON: HUMAN;                                              
SOURCE  68 ORGANISM_TAXID: 9606;                                                
SOURCE  69 GENE: CDC16, ANAPC6;                                                 
SOURCE  70 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  71 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  72 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  73 MOL_ID: 10;                                                          
SOURCE  74 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  75 ORGANISM_COMMON: HUMAN;                                              
SOURCE  76 ORGANISM_TAXID: 9606;                                                
SOURCE  77 GENE: ANAPC10, APC10;                                                
SOURCE  78 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  79 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  80 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  81 MOL_ID: 11;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  83 ORGANISM_COMMON: HUMAN;                                              
SOURCE  84 ORGANISM_TAXID: 9606;                                                
SOURCE  85 GENE: ANAPC13;                                                       
SOURCE  86 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  87 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  88 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  89 MOL_ID: 12;                                                          
SOURCE  90 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  91 ORGANISM_COMMON: HUMAN;                                              
SOURCE  92 ORGANISM_TAXID: 9606;                                                
SOURCE  93 GENE: ANAPC2, APC2, KIAA1406;                                        
SOURCE  94 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  95 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  96 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  97 MOL_ID: 13;                                                          
SOURCE  98 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  99 ORGANISM_COMMON: HUMAN;                                              
SOURCE 100 ORGANISM_TAXID: 9606;                                                
SOURCE 101 GENE: ANAPC5, APC5;                                                  
SOURCE 102 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 103 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 104 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 105 MOL_ID: 14;                                                          
SOURCE 106 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 107 ORGANISM_COMMON: HUMAN;                                              
SOURCE 108 ORGANISM_TAXID: 9606;                                                
SOURCE 109 GENE: FZR1, CDH1, FYR, FZR, KIAA1242;                                
SOURCE 110 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 111 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 112 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 113 MOL_ID: 15;                                                          
SOURCE 114 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE, RATTUS NORVEGICUS;    
SOURCE 115 ORGANISM_COMMON: BAKER'S YEAST, NORWAY RAT;                          
SOURCE 116 ORGANISM_TAXID: 4932, 10116;                                         
SOURCE 117 GENE: HSL1, YKL101W, YKL453;                                         
SOURCE 118 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE 119 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE 120 MOL_ID: 16;                                                          
SOURCE 121 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 122 ORGANISM_COMMON: HUMAN;                                              
SOURCE 123 ORGANISM_TAXID: 9606;                                                
SOURCE 124 GENE: UBE2C, UBCH10;                                                 
SOURCE 125 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 126 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 127 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 128 MOL_ID: 17;                                                          
SOURCE 129 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 130 ORGANISM_COMMON: HUMAN;                                              
SOURCE 131 ORGANISM_TAXID: 9606;                                                
SOURCE 132 GENE: ANAPC7, APC7;                                                  
SOURCE 133 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 134 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 135 EXPRESSION_SYSTEM_TAXID: 7111                                        
KEYWDS    UBIQUITINATION, MULTI-PROTEIN COMPLEX, CELL DIVISION, SIGNALING       
KEYWDS   2 PROTEIN                                                              
EXPDTA    ELECTRON MICROSCOPY                                                   
MDLTYP    CA ATOMS ONLY, CHAIN A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P,  
MDLTYP   2R, S, U, W, X, Y                                                      
AUTHOR    N.G.BROWN,R.VANDERLINDEN,P.DUBE,D.HASELBACH,J.M.PETERS,H.STARK,       
AUTHOR   2 B.A.SCHULMAN                                                         
REVDAT   3   06-NOV-19 5L9U    1       REMARK                                   
REVDAT   2   21-SEP-16 5L9U    1                                                
REVDAT   1   14-SEP-16 5L9U    0                                                
JRNL        AUTH   N.G.BROWN,R.VANDERLINDEN,E.R.WATSON,F.WEISSMANN,A.ORDUREAU,  
JRNL        AUTH 2 K.P.WU,W.ZHANG,S.YU,P.Y.MERCREDI,J.S.HARRISON,I.F.DAVIDSON,  
JRNL        AUTH 3 R.QIAO,Y.LU,P.DUBE,M.R.BRUNNER,C.R.GRACE,D.J.MILLER,         
JRNL        AUTH 4 D.HASELBACH,M.A.JARVIS,M.YAMAGUCHI,D.YANISHEVSKI,G.PETZOLD,  
JRNL        AUTH 5 S.S.SIDHU,B.KUHLMAN,M.W.KIRSCHNER,J.W.HARPER,J.M.PETERS,     
JRNL        AUTH 6 H.STARK,B.A.SCHULMAN                                         
JRNL        TITL   DUAL RING E3 ARCHITECTURES REGULATE MULTIUBIQUITINATION AND  
JRNL        TITL 2 UBIQUITIN CHAIN ELONGATION BY APC/C.                         
JRNL        REF    CELL                          V. 165  1440 2016              
JRNL        REFN                   ISSN 1097-4172                               
JRNL        PMID   27259151                                                     
JRNL        DOI    10.1016/J.CELL.2016.05.037                                   
REMARK   2                                                                      
REMARK   2 RESOLUTION.    6.40 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION                                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 6.400                          
REMARK   3   NUMBER OF PARTICLES               : 135578                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5L9U COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 12-JUN-16.                  
REMARK 100 THE DEPOSITION ID IS D_1200000261.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : MULTI-PROTEIN COMPLEX OF APC/C,   
REMARK 245                                    COACTIVATOR CDH1, AND CROSS-      
REMARK 245                                    LINKED COMPLEX OF UBE2C,          
REMARK 245                                    UBIQUITIN, AND SUBSTRATE-UB_      
REMARK 245                                    VARIANT FUSION.                   
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.10                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : FEI FALCON II (4K X 4K)        
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 40.00                          
REMARK 245   ILLUMINATION MODE                 : SPOT SCAN                      
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 22-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N, O, P, R, S, U,            
REMARK 350                    AND CHAINS: W, X, Y                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     ASN A     3                                                      
REMARK 465     PHE A     4                                                      
REMARK 465     TYR A     5                                                      
REMARK 465     GLU A     6                                                      
REMARK 465     GLU A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     THR A    10                                                      
REMARK 465     ASN A    33                                                      
REMARK 465     ALA A    34                                                      
REMARK 465     LEU A    35                                                      
REMARK 465     ASN A    36                                                      
REMARK 465     LEU A    37                                                      
REMARK 465     GLN A    38                                                      
REMARK 465     LEU A    39                                                      
REMARK 465     ARG A    40                                                      
REMARK 465     GLN A    41                                                      
REMARK 465     LEU A    42                                                      
REMARK 465     GLN A    43                                                      
REMARK 465     PRO A    44                                                      
REMARK 465     ALA A    45                                                      
REMARK 465     SER A    46                                                      
REMARK 465     GLU A    47                                                      
REMARK 465     LEU A    48                                                      
REMARK 465     TRP A    49                                                      
REMARK 465     SER A    50                                                      
REMARK 465     SER A    51                                                      
REMARK 465     ASP A    52                                                      
REMARK 465     GLY A    53                                                      
REMARK 465     ALA A    54                                                      
REMARK 465     ALA A    55                                                      
REMARK 465     GLY A    56                                                      
REMARK 465     LEU A    57                                                      
REMARK 465     VAL A    58                                                      
REMARK 465     GLY A    59                                                      
REMARK 465     SER A    60                                                      
REMARK 465     LEU A    61                                                      
REMARK 465     GLN A    62                                                      
REMARK 465     GLU A    63                                                      
REMARK 465     VAL A    64                                                      
REMARK 465     THR A    65                                                      
REMARK 465     ILE A    66                                                      
REMARK 465     HIS A    67                                                      
REMARK 465     GLU A    68                                                      
REMARK 465     LYS A    69                                                      
REMARK 465     GLN A    70                                                      
REMARK 465     LYS A    71                                                      
REMARK 465     GLY A   105                                                      
REMARK 465     SER A   106                                                      
REMARK 465     LYS A   107                                                      
REMARK 465     SER A   108                                                      
REMARK 465     GLN A   109                                                      
REMARK 465     ALA A   110                                                      
REMARK 465     LEU A   111                                                      
REMARK 465     SER A   134                                                      
REMARK 465     GLN A   135                                                      
REMARK 465     ASP A   136                                                      
REMARK 465     LYS A   137                                                      
REMARK 465     SER A   138                                                      
REMARK 465     GLU A   139                                                      
REMARK 465     LYS A   140                                                      
REMARK 465     ALA A   141                                                      
REMARK 465     TYR A   142                                                      
REMARK 465     SER A   143                                                      
REMARK 465     SER A   144                                                      
REMARK 465     ASN A   145                                                      
REMARK 465     ALA A   193                                                      
REMARK 465     SER A   194                                                      
REMARK 465     SER A   195                                                      
REMARK 465     HIS A   196                                                      
REMARK 465     GLU A   197                                                      
REMARK 465     VAL A   198                                                      
REMARK 465     PRO A   199                                                      
REMARK 465     PRO A   200                                                      
REMARK 465     GLY A   201                                                      
REMARK 465     SER A   202                                                      
REMARK 465     PRO A   203                                                      
REMARK 465     ARG A   204                                                      
REMARK 465     GLU A   205                                                      
REMARK 465     SER A   227                                                      
REMARK 465     GLY A   228                                                      
REMARK 465     SER A   229                                                      
REMARK 465     LEU A   230                                                      
REMARK 465     PHE A   231                                                      
REMARK 465     GLY A   232                                                      
REMARK 465     SER A   233                                                      
REMARK 465     SER A   234                                                      
REMARK 465     ARG A   235                                                      
REMARK 465     GLU A   277                                                      
REMARK 465     GLU A   278                                                      
REMARK 465     GLU A   279                                                      
REMARK 465     ASN A   280                                                      
REMARK 465     VAL A   281                                                      
REMARK 465     VAL A   282                                                      
REMARK 465     LEU A   283                                                      
REMARK 465     LYS A   284                                                      
REMARK 465     PHE A   285                                                      
REMARK 465     SER A   286                                                      
REMARK 465     GLU A   287                                                      
REMARK 465     GLN A   288                                                      
REMARK 465     GLY A   289                                                      
REMARK 465     GLY A   290                                                      
REMARK 465     THR A   291                                                      
REMARK 465     PRO A   292                                                      
REMARK 465     GLN A   293                                                      
REMARK 465     ASN A   294                                                      
REMARK 465     VAL A   295                                                      
REMARK 465     ALA A   296                                                      
REMARK 465     THR A   297                                                      
REMARK 465     SER A   298                                                      
REMARK 465     SER A   299                                                      
REMARK 465     SER A   300                                                      
REMARK 465     LEU A   301                                                      
REMARK 465     THR A   302                                                      
REMARK 465     ALA A   303                                                      
REMARK 465     HIS A   304                                                      
REMARK 465     LEU A   305                                                      
REMARK 465     ARG A   306                                                      
REMARK 465     SER A   307                                                      
REMARK 465     LEU A   308                                                      
REMARK 465     SER A   309                                                      
REMARK 465     LYS A   310                                                      
REMARK 465     GLY A   311                                                      
REMARK 465     ASP A   312                                                      
REMARK 465     SER A   313                                                      
REMARK 465     PRO A   314                                                      
REMARK 465     VAL A   315                                                      
REMARK 465     THR A   316                                                      
REMARK 465     SER A   317                                                      
REMARK 465     PRO A   318                                                      
REMARK 465     PHE A   319                                                      
REMARK 465     GLN A   320                                                      
REMARK 465     ASN A   321                                                      
REMARK 465     TYR A   322                                                      
REMARK 465     SER A   323                                                      
REMARK 465     SER A   324                                                      
REMARK 465     ILE A   325                                                      
REMARK 465     HIS A   326                                                      
REMARK 465     SER A   327                                                      
REMARK 465     GLN A   328                                                      
REMARK 465     SER A   329                                                      
REMARK 465     ARG A   330                                                      
REMARK 465     SER A   331                                                      
REMARK 465     THR A   332                                                      
REMARK 465     SER A   333                                                      
REMARK 465     SER A   334                                                      
REMARK 465     PRO A   335                                                      
REMARK 465     SER A   336                                                      
REMARK 465     LEU A   337                                                      
REMARK 465     HIS A   338                                                      
REMARK 465     SER A   339                                                      
REMARK 465     ARG A   340                                                      
REMARK 465     SER A   341                                                      
REMARK 465     PRO A   342                                                      
REMARK 465     SER A   343                                                      
REMARK 465     ILE A   344                                                      
REMARK 465     SER A   345                                                      
REMARK 465     ASN A   346                                                      
REMARK 465     MET A   347                                                      
REMARK 465     ALA A   348                                                      
REMARK 465     ALA A   349                                                      
REMARK 465     LEU A   350                                                      
REMARK 465     SER A   351                                                      
REMARK 465     ARG A   352                                                      
REMARK 465     ALA A   353                                                      
REMARK 465     HIS A   354                                                      
REMARK 465     SER A   355                                                      
REMARK 465     PRO A   356                                                      
REMARK 465     ALA A   357                                                      
REMARK 465     LEU A   358                                                      
REMARK 465     GLY A   359                                                      
REMARK 465     VAL A   360                                                      
REMARK 465     HIS A   361                                                      
REMARK 465     SER A   362                                                      
REMARK 465     PHE A   363                                                      
REMARK 465     SER A   364                                                      
REMARK 465     GLY A   365                                                      
REMARK 465     VAL A   366                                                      
REMARK 465     GLN A   367                                                      
REMARK 465     ARG A   368                                                      
REMARK 465     PHE A   369                                                      
REMARK 465     ASN A   370                                                      
REMARK 465     ILE A   371                                                      
REMARK 465     SER A   372                                                      
REMARK 465     SER A   373                                                      
REMARK 465     HIS A   374                                                      
REMARK 465     ASN A   375                                                      
REMARK 465     GLN A   376                                                      
REMARK 465     SER A   377                                                      
REMARK 465     PRO A   378                                                      
REMARK 465     LYS A   379                                                      
REMARK 465     ARG A   380                                                      
REMARK 465     HIS A   381                                                      
REMARK 465     SER A   382                                                      
REMARK 465     ILE A   383                                                      
REMARK 465     SER A   384                                                      
REMARK 465     HIS A   385                                                      
REMARK 465     SER A   386                                                      
REMARK 465     PRO A   387                                                      
REMARK 465     ASN A   388                                                      
REMARK 465     SER A   389                                                      
REMARK 465     ASN A   390                                                      
REMARK 465     SER A   391                                                      
REMARK 465     ASN A   392                                                      
REMARK 465     GLY A   393                                                      
REMARK 465     SER A   394                                                      
REMARK 465     PHE A   395                                                      
REMARK 465     LEU A   396                                                      
REMARK 465     ALA A   397                                                      
REMARK 465     PRO A   398                                                      
REMARK 465     GLU A   399                                                      
REMARK 465     THR A   400                                                      
REMARK 465     GLU A   401                                                      
REMARK 465     PRO A   402                                                      
REMARK 465     ILE A   403                                                      
REMARK 465     GLU A   415                                                      
REMARK 465     THR A   416                                                      
REMARK 465     ILE A   417                                                      
REMARK 465     THR A   418                                                      
REMARK 465     ASN A   419                                                      
REMARK 465     ILE A   420                                                      
REMARK 465     ARG A   421                                                      
REMARK 465     GLU A   422                                                      
REMARK 465     LYS A   423                                                      
REMARK 465     ASN A   461                                                      
REMARK 465     ASP A   462                                                      
REMARK 465     LYS A   463                                                      
REMARK 465     GLY A   513                                                      
REMARK 465     LEU A   514                                                      
REMARK 465     PRO A   515                                                      
REMARK 465     ALA A   516                                                      
REMARK 465     PRO A   517                                                      
REMARK 465     SER A   518                                                      
REMARK 465     LEU A   519                                                      
REMARK 465     THR A   520                                                      
REMARK 465     MET A   521                                                      
REMARK 465     SER A   522                                                      
REMARK 465     ASN A   523                                                      
REMARK 465     THR A   524                                                      
REMARK 465     MET A   525                                                      
REMARK 465     PRO A   526                                                      
REMARK 465     ARG A   527                                                      
REMARK 465     PRO A   528                                                      
REMARK 465     SER A   529                                                      
REMARK 465     THR A   530                                                      
REMARK 465     PRO A   531                                                      
REMARK 465     LEU A   532                                                      
REMARK 465     ASP A   533                                                      
REMARK 465     GLY A   534                                                      
REMARK 465     VAL A   535                                                      
REMARK 465     SER A   536                                                      
REMARK 465     THR A   537                                                      
REMARK 465     PRO A   538                                                      
REMARK 465     LYS A   539                                                      
REMARK 465     PRO A   540                                                      
REMARK 465     LEU A   541                                                      
REMARK 465     SER A   542                                                      
REMARK 465     LYS A   543                                                      
REMARK 465     LEU A   544                                                      
REMARK 465     LEU A   545                                                      
REMARK 465     GLY A   546                                                      
REMARK 465     SER A   547                                                      
REMARK 465     LEU A   548                                                      
REMARK 465     ASP A   549                                                      
REMARK 465     GLU A   550                                                      
REMARK 465     VAL A   551                                                      
REMARK 465     VAL A   552                                                      
REMARK 465     LEU A   553                                                      
REMARK 465     LEU A   554                                                      
REMARK 465     SER A   555                                                      
REMARK 465     PRO A   556                                                      
REMARK 465     VAL A   557                                                      
REMARK 465     PRO A   558                                                      
REMARK 465     GLU A   559                                                      
REMARK 465     LEU A   560                                                      
REMARK 465     ARG A   561                                                      
REMARK 465     ASP A   562                                                      
REMARK 465     SER A   563                                                      
REMARK 465     SER A   564                                                      
REMARK 465     LYS A   565                                                      
REMARK 465     LEU A   566                                                      
REMARK 465     HIS A   567                                                      
REMARK 465     ASP A   568                                                      
REMARK 465     SER A   569                                                      
REMARK 465     LEU A   570                                                      
REMARK 465     TYR A   571                                                      
REMARK 465     ASN A   572                                                      
REMARK 465     GLU A   573                                                      
REMARK 465     ASP A   574                                                      
REMARK 465     CYS A   575                                                      
REMARK 465     THR A   576                                                      
REMARK 465     PHE A   577                                                      
REMARK 465     GLN A   578                                                      
REMARK 465     GLN A   579                                                      
REMARK 465     LEU A   580                                                      
REMARK 465     PRO A   648                                                      
REMARK 465     GLY A   649                                                      
REMARK 465     GLY A   650                                                      
REMARK 465     PRO A   651                                                      
REMARK 465     SER A   652                                                      
REMARK 465     ASN A   671                                                      
REMARK 465     THR A   672                                                      
REMARK 465     ASP A   673                                                      
REMARK 465     ARG A   674                                                      
REMARK 465     LEU A   675                                                      
REMARK 465     ALA A   676                                                      
REMARK 465     TRP A   677                                                      
REMARK 465     THR A   678                                                      
REMARK 465     ARG A   679                                                      
REMARK 465     ASN A   680                                                      
REMARK 465     PHE A   681                                                      
REMARK 465     ASP A   682                                                      
REMARK 465     PHE A   683                                                      
REMARK 465     GLU A   684                                                      
REMARK 465     GLY A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     LEU A   687                                                      
REMARK 465     SER A   688                                                      
REMARK 465     PRO A   689                                                      
REMARK 465     VAL A   690                                                      
REMARK 465     ILE A   691                                                      
REMARK 465     ALA A   692                                                      
REMARK 465     PRO A   693                                                      
REMARK 465     LYS A   694                                                      
REMARK 465     LYS A   695                                                      
REMARK 465     ALA A   696                                                      
REMARK 465     ARG A   697                                                      
REMARK 465     PRO A   698                                                      
REMARK 465     SER A   699                                                      
REMARK 465     GLU A   700                                                      
REMARK 465     THR A   701                                                      
REMARK 465     GLY A   702                                                      
REMARK 465     SER A   703                                                      
REMARK 465     LEU A   724                                                      
REMARK 465     ASN A   725                                                      
REMARK 465     ARG A   726                                                      
REMARK 465     SER A   727                                                      
REMARK 465     LEU A   728                                                      
REMARK 465     CYS A   729                                                      
REMARK 465     LEU A   730                                                      
REMARK 465     SER A   731                                                      
REMARK 465     PRO A   732                                                      
REMARK 465     SER A   733                                                      
REMARK 465     GLU A   734                                                      
REMARK 465     ALA A   735                                                      
REMARK 465     SER A   736                                                      
REMARK 465     GLN A   737                                                      
REMARK 465     MET A   738                                                      
REMARK 465     LYS A   739                                                      
REMARK 465     ASP A   740                                                      
REMARK 465     GLU A   741                                                      
REMARK 465     ASP A   742                                                      
REMARK 465     PHE A   743                                                      
REMARK 465     SER A   744                                                      
REMARK 465     GLN A   745                                                      
REMARK 465     ASN A   746                                                      
REMARK 465     LEU A   747                                                      
REMARK 465     SER A   748                                                      
REMARK 465     LEU A   749                                                      
REMARK 465     ASP A   750                                                      
REMARK 465     SER A   751                                                      
REMARK 465     SER A   752                                                      
REMARK 465     THR A   753                                                      
REMARK 465     LEU A   754                                                      
REMARK 465     LEU A   755                                                      
REMARK 465     PHE A   756                                                      
REMARK 465     VAL A   814                                                      
REMARK 465     ARG A   815                                                      
REMARK 465     THR A   816                                                      
REMARK 465     THR A   817                                                      
REMARK 465     GLY A   818                                                      
REMARK 465     GLN A   819                                                      
REMARK 465     VAL A   820                                                      
REMARK 465     CYS A   821                                                      
REMARK 465     THR A   822                                                      
REMARK 465     ILE A   823                                                      
REMARK 465     ASP A   824                                                      
REMARK 465     PRO A   825                                                      
REMARK 465     GLY A   826                                                      
REMARK 465     GLN A   827                                                      
REMARK 465     THR A   828                                                      
REMARK 465     GLY A   829                                                      
REMARK 465     PHE A   830                                                      
REMARK 465     MET A   831                                                      
REMARK 465     HIS A   832                                                      
REMARK 465     HIS A   833                                                      
REMARK 465     PRO A   834                                                      
REMARK 465     SER A   835                                                      
REMARK 465     PHE A   836                                                      
REMARK 465     PHE A   837                                                      
REMARK 465     THR A   838                                                      
REMARK 465     GLY A   883                                                      
REMARK 465     ASP A   884                                                      
REMARK 465     GLU A   885                                                      
REMARK 465     SER A   886                                                      
REMARK 465     LEU A   887                                                      
REMARK 465     VAL A   888                                                      
REMARK 465     SER A   889                                                      
REMARK 465     ASP A   890                                                      
REMARK 465     GLU A   891                                                      
REMARK 465     SER A   892                                                      
REMARK 465     SER A   893                                                      
REMARK 465     GLN A   894                                                      
REMARK 465     TYR A   895                                                      
REMARK 465     LEU A   896                                                      
REMARK 465     THR A   897                                                      
REMARK 465     ARG A   898                                                      
REMARK 465     ILE A   899                                                      
REMARK 465     THR A   900                                                      
REMARK 465     ILE A   901                                                      
REMARK 465     ALA A   902                                                      
REMARK 465     PRO A   903                                                      
REMARK 465     GLN A   904                                                      
REMARK 465     LYS A   905                                                      
REMARK 465     LEU A   906                                                      
REMARK 465     GLN A   907                                                      
REMARK 465     VAL A   908                                                      
REMARK 465     GLU A   909                                                      
REMARK 465     GLN A   910                                                      
REMARK 465     GLU A   911                                                      
REMARK 465     GLU A   912                                                      
REMARK 465     ASN A   913                                                      
REMARK 465     ARG A   914                                                      
REMARK 465     PHE A   915                                                      
REMARK 465     SER A   916                                                      
REMARK 465     PHE A   917                                                      
REMARK 465     ARG A   918                                                      
REMARK 465     HIS A   919                                                      
REMARK 465     SER A   920                                                      
REMARK 465     THR A   921                                                      
REMARK 465     SER A   922                                                      
REMARK 465     VAL A   923                                                      
REMARK 465     ALA A   987                                                      
REMARK 465     CYS A   988                                                      
REMARK 465     GLU A   989                                                      
REMARK 465     GLY A   990                                                      
REMARK 465     ASN A   991                                                      
REMARK 465     LEU A   992                                                      
REMARK 465     PRO A   993                                                      
REMARK 465     LYS A   994                                                      
REMARK 465     GLY A   995                                                      
REMARK 465     LYS A   996                                                      
REMARK 465     SER A   997                                                      
REMARK 465     VAL A   998                                                      
REMARK 465     LEU A   999                                                      
REMARK 465     SER A  1000                                                      
REMARK 465     SER A  1001                                                      
REMARK 465     ASP A  1002                                                      
REMARK 465     VAL A  1003                                                      
REMARK 465     PRO A  1004                                                      
REMARK 465     SER A  1005                                                      
REMARK 465     GLY A  1006                                                      
REMARK 465     THR A  1007                                                      
REMARK 465     GLU A  1008                                                      
REMARK 465     THR A  1009                                                      
REMARK 465     GLU A  1010                                                      
REMARK 465     GLU A  1011                                                      
REMARK 465     GLU A  1012                                                      
REMARK 465     ARG A  1334                                                      
REMARK 465     ARG A  1335                                                      
REMARK 465     PHE A  1336                                                      
REMARK 465     GLN A  1337                                                      
REMARK 465     THR A  1338                                                      
REMARK 465     GLY A  1339                                                      
REMARK 465     MET A  1340                                                      
REMARK 465     HIS A  1341                                                      
REMARK 465     ARG A  1342                                                      
REMARK 465     GLU A  1343                                                      
REMARK 465     LYS A  1344                                                      
REMARK 465     HIS A  1345                                                      
REMARK 465     LYS A  1346                                                      
REMARK 465     SER A  1438                                                      
REMARK 465     ILE A  1439                                                      
REMARK 465     SER A  1440                                                      
REMARK 465     LEU A  1441                                                      
REMARK 465     SER A  1442                                                      
REMARK 465     GLU A  1443                                                      
REMARK 465     ILE A  1444                                                      
REMARK 465     GLU A  1445                                                      
REMARK 465     LEU A  1446                                                      
REMARK 465     PRO A  1447                                                      
REMARK 465     CYS A  1448                                                      
REMARK 465     SER A  1449                                                      
REMARK 465     GLU A  1450                                                      
REMARK 465     ASP A  1451                                                      
REMARK 465     SER A  1681                                                      
REMARK 465     LYS A  1682                                                      
REMARK 465     GLY A  1683                                                      
REMARK 465     GLY A  1704                                                      
REMARK 465     GLN A  1705                                                      
REMARK 465     LEU A  1706                                                      
REMARK 465     SER A  1707                                                      
REMARK 465     TYR A  1708                                                      
REMARK 465     LYS A  1709                                                      
REMARK 465     GLU A  1710                                                      
REMARK 465     ASP A  1711                                                      
REMARK 465     PRO A  1712                                                      
REMARK 465     MET A  1713                                                      
REMARK 465     GLY A  1714                                                      
REMARK 465     TRP A  1715                                                      
REMARK 465     GLN A  1716                                                      
REMARK 465     SER A  1717                                                      
REMARK 465     LEU A  1718                                                      
REMARK 465     LEU A  1719                                                      
REMARK 465     ALA A  1720                                                      
REMARK 465     GLN A  1721                                                      
REMARK 465     THR A  1722                                                      
REMARK 465     VAL A  1723                                                      
REMARK 465     ALA A  1724                                                      
REMARK 465     ASN A  1725                                                      
REMARK 465     ARG A  1726                                                      
REMARK 465     ASN A  1727                                                      
REMARK 465     SER A  1728                                                      
REMARK 465     GLU A  1729                                                      
REMARK 465     ALA A  1730                                                      
REMARK 465     ARG A  1731                                                      
REMARK 465     ALA A  1732                                                      
REMARK 465     PHE A  1733                                                      
REMARK 465     LYS A  1734                                                      
REMARK 465     PRO A  1735                                                      
REMARK 465     GLU A  1736                                                      
REMARK 465     THR A  1737                                                      
REMARK 465     ILE A  1738                                                      
REMARK 465     SER A  1739                                                      
REMARK 465     ALA A  1740                                                      
REMARK 465     PHE A  1741                                                      
REMARK 465     THR A  1742                                                      
REMARK 465     SER A  1743                                                      
REMARK 465     ASP A  1744                                                      
REMARK 465     PRO A  1745                                                      
REMARK 465     ALA A  1746                                                      
REMARK 465     LEU A  1747                                                      
REMARK 465     LEU A  1748                                                      
REMARK 465     PRO A  1757                                                      
REMARK 465     THR A  1758                                                      
REMARK 465     VAL A  1759                                                      
REMARK 465     ASN A  1760                                                      
REMARK 465     MET A  1761                                                      
REMARK 465     GLY A  1762                                                      
REMARK 465     GLN A  1763                                                      
REMARK 465     LYS A  1764                                                      
REMARK 465     GLN A  1765                                                      
REMARK 465     GLU A  1766                                                      
REMARK 465     ILE A  1767                                                      
REMARK 465     LEU A  1768                                                      
REMARK 465     ASP A  1769                                                      
REMARK 465     LEU A  1770                                                      
REMARK 465     GLU A  1828                                                      
REMARK 465     ARG A  1829                                                      
REMARK 465     LEU A  1830                                                      
REMARK 465     GLN A  1831                                                      
REMARK 465     ASN A  1832                                                      
REMARK 465     HIS A  1833                                                      
REMARK 465     PRO A  1834                                                      
REMARK 465     LYS A  1835                                                      
REMARK 465     ARG A  1836                                                      
REMARK 465     GLY A  1837                                                      
REMARK 465     LEU A  1838                                                      
REMARK 465     GLY A  1874                                                      
REMARK 465     GLN A  1875                                                      
REMARK 465     PRO A  1876                                                      
REMARK 465     ALA A  1896                                                      
REMARK 465     PRO A  1897                                                      
REMARK 465     GLN A  1898                                                      
REMARK 465     HIS A  1899                                                      
REMARK 465     LEU A  1900                                                      
REMARK 465     PRO A  1901                                                      
REMARK 465     PRO A  1902                                                      
REMARK 465     ILE A  1903                                                      
REMARK 465     GLY A  1904                                                      
REMARK 465     LEU A  1905                                                      
REMARK 465     GLU A  1906                                                      
REMARK 465     GLY A  1907                                                      
REMARK 465     PHE A  1918                                                      
REMARK 465     LYS A  1919                                                      
REMARK 465     GLN A  1920                                                      
REMARK 465     LEU A  1921                                                      
REMARK 465     LYS A  1922                                                      
REMARK 465     MET A  1923                                                      
REMARK 465     PRO A  1924                                                      
REMARK 465     VAL A  1925                                                      
REMARK 465     ARG A  1926                                                      
REMARK 465     ALA A  1927                                                      
REMARK 465     LEU A  1928                                                      
REMARK 465     LEU A  1929                                                      
REMARK 465     ARG A  1930                                                      
REMARK 465     LEU A  1931                                                      
REMARK 465     ALA A  1932                                                      
REMARK 465     PRO A  1933                                                      
REMARK 465     LEU A  1934                                                      
REMARK 465     LEU A  1935                                                      
REMARK 465     LEU A  1936                                                      
REMARK 465     GLY A  1937                                                      
REMARK 465     ASN A  1938                                                      
REMARK 465     PRO A  1939                                                      
REMARK 465     GLN A  1940                                                      
REMARK 465     PRO A  1941                                                      
REMARK 465     MET A  1942                                                      
REMARK 465     VAL A  1943                                                      
REMARK 465     MET A  1944                                                      
REMARK 465     MET B     1                                                      
REMARK 465     VAL B    17                                                      
REMARK 465     ALA B    18                                                      
REMARK 465     ASN B    19                                                      
REMARK 465     ASP B    20                                                      
REMARK 465     ASN B    31                                                      
REMARK 465     GLY B    32                                                      
REMARK 465     LYS B    38                                                      
REMARK 465     VAL B    39                                                      
REMARK 465     PRO B    40                                                      
REMARK 465     GLY B    41                                                      
REMARK 465     ASP B    42                                                      
REMARK 465     ASP B    43                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     THR C     5                                                      
REMARK 465     SER C     6                                                      
REMARK 465     MET C     7                                                      
REMARK 465     VAL C     8                                                      
REMARK 465     PRO C     9                                                      
REMARK 465     VAL C    10                                                      
REMARK 465     ALA C    11                                                      
REMARK 465     VAL C    12                                                      
REMARK 465     THR C    13                                                      
REMARK 465     ALA C    14                                                      
REMARK 465     ALA C    15                                                      
REMARK 465     VAL C    16                                                      
REMARK 465     ALA C    17                                                      
REMARK 465     PRO C    18                                                      
REMARK 465     VAL C    19                                                      
REMARK 465     LEU C    20                                                      
REMARK 465     SER C    21                                                      
REMARK 465     ILE C    22                                                      
REMARK 465     ASN C    23                                                      
REMARK 465     SER C    24                                                      
REMARK 465     ASP C    25                                                      
REMARK 465     CYS C   500                                                      
REMARK 465     GLY C   501                                                      
REMARK 465     GLU C   502                                                      
REMARK 465     ILE C   503                                                      
REMARK 465     VAL C   504                                                      
REMARK 465     GLU C   505                                                      
REMARK 465     HIS C   506                                                      
REMARK 465     LEU C   507                                                      
REMARK 465     GLU C   508                                                      
REMARK 465     GLU C   509                                                      
REMARK 465     SER C   510                                                      
REMARK 465     THR C   511                                                      
REMARK 465     ALA C   512                                                      
REMARK 465     PHE C   513                                                      
REMARK 465     ARG C   514                                                      
REMARK 465     TYR C   515                                                      
REMARK 465     LEU C   516                                                      
REMARK 465     ALA C   517                                                      
REMARK 465     GLN C   518                                                      
REMARK 465     TYR C   519                                                      
REMARK 465     TYR C   520                                                      
REMARK 465     PHE C   521                                                      
REMARK 465     LYS C   522                                                      
REMARK 465     CYS C   523                                                      
REMARK 465     LYS C   524                                                      
REMARK 465     LEU C   525                                                      
REMARK 465     TRP C   526                                                      
REMARK 465     ASP C   527                                                      
REMARK 465     GLU C   528                                                      
REMARK 465     ALA C   529                                                      
REMARK 465     SER C   530                                                      
REMARK 465     THR C   531                                                      
REMARK 465     CYS C   532                                                      
REMARK 465     ALA C   533                                                      
REMARK 465     GLN C   534                                                      
REMARK 465     LYS C   535                                                      
REMARK 465     CYS C   536                                                      
REMARK 465     CYS C   537                                                      
REMARK 465     ALA C   538                                                      
REMARK 465     PHE C   539                                                      
REMARK 465     ASN C   540                                                      
REMARK 465     ASP C   541                                                      
REMARK 465     THR C   542                                                      
REMARK 465     ARG C   543                                                      
REMARK 465     GLU C   544                                                      
REMARK 465     GLU C   545                                                      
REMARK 465     GLY C   546                                                      
REMARK 465     LYS C   547                                                      
REMARK 465     ALA C   548                                                      
REMARK 465     LEU C   549                                                      
REMARK 465     LEU C   550                                                      
REMARK 465     ARG C   551                                                      
REMARK 465     GLN C   552                                                      
REMARK 465     ILE C   553                                                      
REMARK 465     LEU C   554                                                      
REMARK 465     GLN C   555                                                      
REMARK 465     LEU C   556                                                      
REMARK 465     ARG C   557                                                      
REMARK 465     ASN C   558                                                      
REMARK 465     GLN C   559                                                      
REMARK 465     GLY C   560                                                      
REMARK 465     GLU C   561                                                      
REMARK 465     THR C   562                                                      
REMARK 465     PRO C   563                                                      
REMARK 465     THR C   564                                                      
REMARK 465     THR C   565                                                      
REMARK 465     GLU C   566                                                      
REMARK 465     VAL C   567                                                      
REMARK 465     PRO C   568                                                      
REMARK 465     ALA C   569                                                      
REMARK 465     PRO C   570                                                      
REMARK 465     PHE C   571                                                      
REMARK 465     PHE C   572                                                      
REMARK 465     LEU C   573                                                      
REMARK 465     PRO C   574                                                      
REMARK 465     ALA C   575                                                      
REMARK 465     SER C   576                                                      
REMARK 465     LEU C   577                                                      
REMARK 465     SER C   578                                                      
REMARK 465     ALA C   579                                                      
REMARK 465     ASN C   580                                                      
REMARK 465     ASN C   581                                                      
REMARK 465     THR C   582                                                      
REMARK 465     PRO C   583                                                      
REMARK 465     THR C   584                                                      
REMARK 465     ARG C   585                                                      
REMARK 465     ARG C   586                                                      
REMARK 465     VAL C   587                                                      
REMARK 465     SER C   588                                                      
REMARK 465     PRO C   589                                                      
REMARK 465     LEU C   590                                                      
REMARK 465     ASN C   591                                                      
REMARK 465     LEU C   592                                                      
REMARK 465     SER C   593                                                      
REMARK 465     SER C   594                                                      
REMARK 465     VAL C   595                                                      
REMARK 465     THR C   596                                                      
REMARK 465     PRO C   597                                                      
REMARK 465     MET D     1                                                      
REMARK 465     PRO D    57                                                      
REMARK 465     ALA D    58                                                      
REMARK 465     SER D    59                                                      
REMARK 465     GLU D    60                                                      
REMARK 465     HIS D    61                                                      
REMARK 465     TYR D    62                                                      
REMARK 465     ASP D    63                                                      
REMARK 465     ASP D    64                                                      
REMARK 465     GLU D    65                                                      
REMARK 465     GLU D    66                                                      
REMARK 465     GLU D    67                                                      
REMARK 465     GLU D    68                                                      
REMARK 465     ASP D    69                                                      
REMARK 465     ASP D    70                                                      
REMARK 465     GLU D    71                                                      
REMARK 465     ASP D    72                                                      
REMARK 465     ASP D    73                                                      
REMARK 465     GLU D    74                                                      
REMARK 465     ASP D    75                                                      
REMARK 465     SER D    76                                                      
REMARK 465     GLU D    77                                                      
REMARK 465     GLU D    78                                                      
REMARK 465     ASP D    79                                                      
REMARK 465     SER D    80                                                      
REMARK 465     GLU D    81                                                      
REMARK 465     ASP D    82                                                      
REMARK 465     ASP D    83                                                      
REMARK 465     GLU D    84                                                      
REMARK 465     ASP D    85                                                      
REMARK 465     MET D    86                                                      
REMARK 465     GLN D    87                                                      
REMARK 465     ASP D    88                                                      
REMARK 465     MET D    89                                                      
REMARK 465     ASP D    90                                                      
REMARK 465     GLU D    91                                                      
REMARK 465     MET D    92                                                      
REMARK 465     ASN D    93                                                      
REMARK 465     ASP D    94                                                      
REMARK 465     TYR D    95                                                      
REMARK 465     ASN D    96                                                      
REMARK 465     GLU D    97                                                      
REMARK 465     SER D    98                                                      
REMARK 465     PRO D    99                                                      
REMARK 465     ASP D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     GLY D   102                                                      
REMARK 465     GLU D   103                                                      
REMARK 465     VAL D   104                                                      
REMARK 465     ASN D   105                                                      
REMARK 465     GLU D   106                                                      
REMARK 465     VAL D   107                                                      
REMARK 465     ASP D   108                                                      
REMARK 465     MET D   109                                                      
REMARK 465     GLU D   110                                                      
REMARK 465     GLY D   111                                                      
REMARK 465     ASN D   112                                                      
REMARK 465     GLU D   113                                                      
REMARK 465     GLN D   114                                                      
REMARK 465     ASP D   115                                                      
REMARK 465     GLN D   116                                                      
REMARK 465     ASP D   117                                                      
REMARK 465     GLN D   118                                                      
REMARK 465     TRP D   119                                                      
REMARK 465     MET D   120                                                      
REMARK 465     ILE D   121                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     SER E     4                                                      
REMARK 465     SER E     5                                                      
REMARK 465     SER E     6                                                      
REMARK 465     SER E     7                                                      
REMARK 465     SER E     8                                                      
REMARK 465     SER E     9                                                      
REMARK 465     ALA E    10                                                      
REMARK 465     GLY E    11                                                      
REMARK 465     GLY E    12                                                      
REMARK 465     VAL E    13                                                      
REMARK 465     SER E    14                                                      
REMARK 465     GLY E    15                                                      
REMARK 465     SER E    16                                                      
REMARK 465     SER E    17                                                      
REMARK 465     VAL E    18                                                      
REMARK 465     THR E    19                                                      
REMARK 465     GLY E    20                                                      
REMARK 465     SER E    21                                                      
REMARK 465     GLY E    22                                                      
REMARK 465     PHE E    23                                                      
REMARK 465     SER E    24                                                      
REMARK 465     VAL E    25                                                      
REMARK 465     SER E    26                                                      
REMARK 465     ASP E    27                                                      
REMARK 465     LEU E    28                                                      
REMARK 465     ALA E    29                                                      
REMARK 465     PRO E    30                                                      
REMARK 465     PRO E    31                                                      
REMARK 465     ARG E    32                                                      
REMARK 465     LYS E    33                                                      
REMARK 465     ALA E    34                                                      
REMARK 465     LEU E    35                                                      
REMARK 465     PHE E    36                                                      
REMARK 465     THR E    37                                                      
REMARK 465     TYR E    38                                                      
REMARK 465     PRO E    39                                                      
REMARK 465     LYS E    40                                                      
REMARK 465     GLY E    41                                                      
REMARK 465     ALA E    42                                                      
REMARK 465     GLY E    43                                                      
REMARK 465     GLU E    44                                                      
REMARK 465     MET E    45                                                      
REMARK 465     LEU E    46                                                      
REMARK 465     GLU E    47                                                      
REMARK 465     ASP E    48                                                      
REMARK 465     GLY E    49                                                      
REMARK 465     SER E    50                                                      
REMARK 465     GLU E    51                                                      
REMARK 465     SER E   108                                                      
REMARK 465     SER E   109                                                      
REMARK 465     GLY E   110                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     VAL F     3                                                      
REMARK 465     LEU F     4                                                      
REMARK 465     THR F   171                                                      
REMARK 465     SER F   172                                                      
REMARK 465     LEU F   173                                                      
REMARK 465     GLN F   174                                                      
REMARK 465     ASN F   175                                                      
REMARK 465     PHE F   176                                                      
REMARK 465     SER F   177                                                      
REMARK 465     ASN F   178                                                      
REMARK 465     CYS F   179                                                      
REMARK 465     LEU F   180                                                      
REMARK 465     PRO F   181                                                      
REMARK 465     ASN F   182                                                      
REMARK 465     SER F   183                                                      
REMARK 465     CYS F   184                                                      
REMARK 465     THR F   185                                                      
REMARK 465     THR F   186                                                      
REMARK 465     GLN F   187                                                      
REMARK 465     VAL F   188                                                      
REMARK 465     PRO F   189                                                      
REMARK 465     ASN F   190                                                      
REMARK 465     HIS F   191                                                      
REMARK 465     SER F   192                                                      
REMARK 465     LEU F   193                                                      
REMARK 465     SER F   194                                                      
REMARK 465     HIS F   195                                                      
REMARK 465     ARG F   196                                                      
REMARK 465     GLN F   197                                                      
REMARK 465     PRO F   198                                                      
REMARK 465     GLU F   199                                                      
REMARK 465     THR F   200                                                      
REMARK 465     VAL F   201                                                      
REMARK 465     LEU F   202                                                      
REMARK 465     THR F   203                                                      
REMARK 465     GLU F   204                                                      
REMARK 465     THR F   205                                                      
REMARK 465     PRO F   206                                                      
REMARK 465     GLN F   207                                                      
REMARK 465     ASP F   208                                                      
REMARK 465     THR F   209                                                      
REMARK 465     ILE F   210                                                      
REMARK 465     GLU F   211                                                      
REMARK 465     LEU F   212                                                      
REMARK 465     ASN F   213                                                      
REMARK 465     ARG F   214                                                      
REMARK 465     LEU F   215                                                      
REMARK 465     ASN F   216                                                      
REMARK 465     LEU F   217                                                      
REMARK 465     GLU F   218                                                      
REMARK 465     SER F   219                                                      
REMARK 465     SER F   220                                                      
REMARK 465     ASN F   221                                                      
REMARK 465     SER F   222                                                      
REMARK 465     LYS F   223                                                      
REMARK 465     TYR F   224                                                      
REMARK 465     SER F   225                                                      
REMARK 465     LEU F   226                                                      
REMARK 465     ASN F   227                                                      
REMARK 465     THR F   228                                                      
REMARK 465     ASP F   229                                                      
REMARK 465     SER F   230                                                      
REMARK 465     SER F   231                                                      
REMARK 465     VAL F   232                                                      
REMARK 465     SER F   233                                                      
REMARK 465     TYR F   234                                                      
REMARK 465     ILE F   235                                                      
REMARK 465     ASP F   236                                                      
REMARK 465     SER F   237                                                      
REMARK 465     ALA F   238                                                      
REMARK 465     VAL F   239                                                      
REMARK 465     ILE F   240                                                      
REMARK 465     SER F   241                                                      
REMARK 465     PRO F   242                                                      
REMARK 465     ASP F   243                                                      
REMARK 465     THR F   244                                                      
REMARK 465     VAL F   245                                                      
REMARK 465     PRO F   246                                                      
REMARK 465     LEU F   247                                                      
REMARK 465     GLY F   248                                                      
REMARK 465     THR F   249                                                      
REMARK 465     GLY F   250                                                      
REMARK 465     THR F   251                                                      
REMARK 465     SER F   252                                                      
REMARK 465     ILE F   253                                                      
REMARK 465     LEU F   254                                                      
REMARK 465     SER F   255                                                      
REMARK 465     LYS F   256                                                      
REMARK 465     GLN F   257                                                      
REMARK 465     VAL F   258                                                      
REMARK 465     GLN F   259                                                      
REMARK 465     ASN F   260                                                      
REMARK 465     LYS F   261                                                      
REMARK 465     PRO F   262                                                      
REMARK 465     LYS F   263                                                      
REMARK 465     THR F   264                                                      
REMARK 465     GLY F   265                                                      
REMARK 465     ARG F   266                                                      
REMARK 465     SER F   267                                                      
REMARK 465     LEU F   268                                                      
REMARK 465     LEU F   269                                                      
REMARK 465     GLY F   270                                                      
REMARK 465     GLY F   271                                                      
REMARK 465     PRO F   272                                                      
REMARK 465     ALA F   273                                                      
REMARK 465     ALA F   274                                                      
REMARK 465     LEU F   275                                                      
REMARK 465     SER F   276                                                      
REMARK 465     PRO F   277                                                      
REMARK 465     LEU F   278                                                      
REMARK 465     THR F   279                                                      
REMARK 465     PRO F   280                                                      
REMARK 465     SER F   281                                                      
REMARK 465     PHE F   282                                                      
REMARK 465     GLY F   283                                                      
REMARK 465     ILE F   284                                                      
REMARK 465     LEU F   285                                                      
REMARK 465     PRO F   286                                                      
REMARK 465     LEU F   287                                                      
REMARK 465     GLU F   288                                                      
REMARK 465     THR F   289                                                      
REMARK 465     PRO F   290                                                      
REMARK 465     SER F   291                                                      
REMARK 465     PRO F   292                                                      
REMARK 465     GLY F   293                                                      
REMARK 465     ASP F   294                                                      
REMARK 465     GLY F   295                                                      
REMARK 465     SER F   296                                                      
REMARK 465     TYR F   297                                                      
REMARK 465     LEU F   298                                                      
REMARK 465     GLN F   299                                                      
REMARK 465     ASN F   300                                                      
REMARK 465     TYR F   301                                                      
REMARK 465     THR F   302                                                      
REMARK 465     ASN F   303                                                      
REMARK 465     THR F   304                                                      
REMARK 465     PRO F   305                                                      
REMARK 465     PRO F   306                                                      
REMARK 465     VAL F   307                                                      
REMARK 465     ILE F   308                                                      
REMARK 465     ASP F   309                                                      
REMARK 465     VAL F   310                                                      
REMARK 465     PRO F   311                                                      
REMARK 465     SER F   312                                                      
REMARK 465     THR F   313                                                      
REMARK 465     GLY F   314                                                      
REMARK 465     ALA F   315                                                      
REMARK 465     PRO F   316                                                      
REMARK 465     SER F   317                                                      
REMARK 465     LYS F   318                                                      
REMARK 465     LYS F   319                                                      
REMARK 465     SER F   320                                                      
REMARK 465     VAL F   321                                                      
REMARK 465     ALA F   322                                                      
REMARK 465     ARG F   323                                                      
REMARK 465     ILE F   324                                                      
REMARK 465     GLY F   325                                                      
REMARK 465     GLN F   326                                                      
REMARK 465     THR F   327                                                      
REMARK 465     GLY F   328                                                      
REMARK 465     THR F   329                                                      
REMARK 465     LYS F   330                                                      
REMARK 465     SER F   331                                                      
REMARK 465     VAL F   332                                                      
REMARK 465     PHE F   333                                                      
REMARK 465     SER F   334                                                      
REMARK 465     GLN F   335                                                      
REMARK 465     SER F   336                                                      
REMARK 465     GLY F   337                                                      
REMARK 465     ASN F   338                                                      
REMARK 465     SER F   339                                                      
REMARK 465     ARG F   340                                                      
REMARK 465     GLU F   341                                                      
REMARK 465     VAL F   342                                                      
REMARK 465     THR F   343                                                      
REMARK 465     PRO F   344                                                      
REMARK 465     ILE F   345                                                      
REMARK 465     LEU F   346                                                      
REMARK 465     ALA F   347                                                      
REMARK 465     GLN F   348                                                      
REMARK 465     THR F   349                                                      
REMARK 465     GLN F   350                                                      
REMARK 465     SER F   351                                                      
REMARK 465     SER F   352                                                      
REMARK 465     GLY F   353                                                      
REMARK 465     PRO F   354                                                      
REMARK 465     GLN F   355                                                      
REMARK 465     THR F   356                                                      
REMARK 465     SER F   357                                                      
REMARK 465     THR F   358                                                      
REMARK 465     THR F   359                                                      
REMARK 465     PRO F   360                                                      
REMARK 465     GLN F   361                                                      
REMARK 465     VAL F   362                                                      
REMARK 465     LEU F   363                                                      
REMARK 465     SER F   364                                                      
REMARK 465     PRO F   365                                                      
REMARK 465     THR F   366                                                      
REMARK 465     ILE F   367                                                      
REMARK 465     THR F   368                                                      
REMARK 465     SER F   369                                                      
REMARK 465     PRO F   370                                                      
REMARK 465     PRO F   371                                                      
REMARK 465     ASN F   372                                                      
REMARK 465     ALA F   373                                                      
REMARK 465     LEU F   374                                                      
REMARK 465     PRO F   375                                                      
REMARK 465     ARG F   376                                                      
REMARK 465     ARG F   377                                                      
REMARK 465     SER F   378                                                      
REMARK 465     SER F   379                                                      
REMARK 465     ARG F   380                                                      
REMARK 465     LEU F   381                                                      
REMARK 465     PHE F   382                                                      
REMARK 465     THR F   383                                                      
REMARK 465     SER F   384                                                      
REMARK 465     ASP F   385                                                      
REMARK 465     SER F   386                                                      
REMARK 465     SER F   387                                                      
REMARK 465     THR F   388                                                      
REMARK 465     THR F   389                                                      
REMARK 465     LYS F   390                                                      
REMARK 465     GLU F   391                                                      
REMARK 465     ASN F   392                                                      
REMARK 465     SER F   393                                                      
REMARK 465     LYS F   394                                                      
REMARK 465     LYS F   395                                                      
REMARK 465     LEU F   396                                                      
REMARK 465     LYS F   397                                                      
REMARK 465     MET F   398                                                      
REMARK 465     LYS F   399                                                      
REMARK 465     PHE F   400                                                      
REMARK 465     PRO F   401                                                      
REMARK 465     PRO F   402                                                      
REMARK 465     LYS F   403                                                      
REMARK 465     ILE F   404                                                      
REMARK 465     PRO F   405                                                      
REMARK 465     ASN F   406                                                      
REMARK 465     ARG F   407                                                      
REMARK 465     LYS F   408                                                      
REMARK 465     THR F   409                                                      
REMARK 465     LYS F   410                                                      
REMARK 465     SER F   411                                                      
REMARK 465     LYS F   412                                                      
REMARK 465     THR F   413                                                      
REMARK 465     ASN F   414                                                      
REMARK 465     LYS F   415                                                      
REMARK 465     GLY F   416                                                      
REMARK 465     GLY F   417                                                      
REMARK 465     ILE F   418                                                      
REMARK 465     THR F   419                                                      
REMARK 465     GLN F   420                                                      
REMARK 465     PRO F   421                                                      
REMARK 465     ASN F   422                                                      
REMARK 465     ILE F   423                                                      
REMARK 465     ASN F   424                                                      
REMARK 465     ASP F   425                                                      
REMARK 465     SER F   426                                                      
REMARK 465     LEU F   427                                                      
REMARK 465     GLU F   428                                                      
REMARK 465     ILE F   429                                                      
REMARK 465     THR F   430                                                      
REMARK 465     LYS F   431                                                      
REMARK 465     LEU F   432                                                      
REMARK 465     ASP F   433                                                      
REMARK 465     SER F   434                                                      
REMARK 465     SER F   435                                                      
REMARK 465     ILE F   436                                                      
REMARK 465     ILE F   437                                                      
REMARK 465     SER F   438                                                      
REMARK 465     GLU F   439                                                      
REMARK 465     GLY F   440                                                      
REMARK 465     LYS F   441                                                      
REMARK 465     ILE F   442                                                      
REMARK 465     SER F   443                                                      
REMARK 465     THR F   444                                                      
REMARK 465     ILE F   445                                                      
REMARK 465     THR F   446                                                      
REMARK 465     PRO F   447                                                      
REMARK 465     GLN F   448                                                      
REMARK 465     ILE F   449                                                      
REMARK 465     GLN F   450                                                      
REMARK 465     ASP F   767                                                      
REMARK 465     PRO F   768                                                      
REMARK 465     LYS F   769                                                      
REMARK 465     GLY F   770                                                      
REMARK 465     ALA F   771                                                      
REMARK 465     ASN F   772                                                      
REMARK 465     ASN F   773                                                      
REMARK 465     GLN F   774                                                      
REMARK 465     ILE F   775                                                      
REMARK 465     LYS F   776                                                      
REMARK 465     GLU F   777                                                      
REMARK 465     ALA F   778                                                      
REMARK 465     ILE F   779                                                      
REMARK 465     ASP F   780                                                      
REMARK 465     LYS F   781                                                      
REMARK 465     ARG F   782                                                      
REMARK 465     TYR F   783                                                      
REMARK 465     LEU F   784                                                      
REMARK 465     PRO F   785                                                      
REMARK 465     ASP F   786                                                      
REMARK 465     ASP F   787                                                      
REMARK 465     GLU F   788                                                      
REMARK 465     GLU F   789                                                      
REMARK 465     PRO F   790                                                      
REMARK 465     ILE F   791                                                      
REMARK 465     THR F   792                                                      
REMARK 465     GLN F   793                                                      
REMARK 465     GLU F   794                                                      
REMARK 465     GLU F   795                                                      
REMARK 465     GLN F   796                                                      
REMARK 465     ILE F   797                                                      
REMARK 465     MET F   798                                                      
REMARK 465     GLY F   799                                                      
REMARK 465     THR F   800                                                      
REMARK 465     ASP F   801                                                      
REMARK 465     GLU F   802                                                      
REMARK 465     SER F   803                                                      
REMARK 465     GLN F   804                                                      
REMARK 465     GLU F   805                                                      
REMARK 465     SER F   806                                                      
REMARK 465     SER F   807                                                      
REMARK 465     MET F   808                                                      
REMARK 465     THR F   809                                                      
REMARK 465     ASP F   810                                                      
REMARK 465     ALA F   811                                                      
REMARK 465     ASP F   812                                                      
REMARK 465     ASP F   813                                                      
REMARK 465     THR F   814                                                      
REMARK 465     GLN F   815                                                      
REMARK 465     LEU F   816                                                      
REMARK 465     HIS F   817                                                      
REMARK 465     ALA F   818                                                      
REMARK 465     ALA F   819                                                      
REMARK 465     GLU F   820                                                      
REMARK 465     SER F   821                                                      
REMARK 465     ASP F   822                                                      
REMARK 465     GLU F   823                                                      
REMARK 465     PHE F   824                                                      
REMARK 465     LEU G    26                                                      
REMARK 465     GLU G    27                                                      
REMARK 465     THR G    28                                                      
REMARK 465     ARG G    29                                                      
REMARK 465     LYS G    30                                                      
REMARK 465     LYS G    31                                                      
REMARK 465     GLN G    32                                                      
REMARK 465     LYS G    33                                                      
REMARK 465     GLU G    34                                                      
REMARK 465     ASP G    35                                                      
REMARK 465     VAL G    36                                                      
REMARK 465     GLU G    37                                                      
REMARK 465     VAL G    38                                                      
REMARK 465     VAL G    39                                                      
REMARK 465     GLY G    40                                                      
REMARK 465     GLY G    41                                                      
REMARK 465     SER G    42                                                      
REMARK 465     ASP G    43                                                      
REMARK 465     GLY G    44                                                      
REMARK 465     GLU G    45                                                      
REMARK 465     GLY G    46                                                      
REMARK 465     ALA G    47                                                      
REMARK 465     ILE G    48                                                      
REMARK 465     GLY G    49                                                      
REMARK 465     LEU G    50                                                      
REMARK 465     SER G    51                                                      
REMARK 465     SER G    52                                                      
REMARK 465     ASP G    53                                                      
REMARK 465     PRO G    54                                                      
REMARK 465     LYS G    55                                                      
REMARK 465     SER G    56                                                      
REMARK 465     ARG G    57                                                      
REMARK 465     GLU G    58                                                      
REMARK 465     GLN G    59                                                      
REMARK 465     MET G    60                                                      
REMARK 465     ILE G    61                                                      
REMARK 465     ASN G    62                                                      
REMARK 465     ASP G    63                                                      
REMARK 465     ARG G    64                                                      
REMARK 465     ILE G    65                                                      
REMARK 465     GLY G    66                                                      
REMARK 465     TYR G    67                                                      
REMARK 465     LYS G    68                                                      
REMARK 465     PRO G    69                                                      
REMARK 465     GLN G    70                                                      
REMARK 465     PRO G    71                                                      
REMARK 465     LYS G    72                                                      
REMARK 465     PRO G    73                                                      
REMARK 465     ASN G    74                                                      
REMARK 465     ASN G    75                                                      
REMARK 465     ARG G    76                                                      
REMARK 465     SER G    77                                                      
REMARK 465     SER G    78                                                      
REMARK 465     GLN G    79                                                      
REMARK 465     PHE G    80                                                      
REMARK 465     GLY G    81                                                      
REMARK 465     SER G    82                                                      
REMARK 465     LEU G    83                                                      
REMARK 465     GLU G    84                                                      
REMARK 465     PHE G    85                                                      
REMARK 465     MET H     1                                                      
REMARK 465     THR H     2                                                      
REMARK 465     VAL H     3                                                      
REMARK 465     LEU H     4                                                      
REMARK 465     THR H   171                                                      
REMARK 465     SER H   172                                                      
REMARK 465     LEU H   173                                                      
REMARK 465     GLN H   174                                                      
REMARK 465     ASN H   175                                                      
REMARK 465     PHE H   176                                                      
REMARK 465     SER H   177                                                      
REMARK 465     ASN H   178                                                      
REMARK 465     CYS H   179                                                      
REMARK 465     LEU H   180                                                      
REMARK 465     PRO H   181                                                      
REMARK 465     ASN H   182                                                      
REMARK 465     SER H   183                                                      
REMARK 465     CYS H   184                                                      
REMARK 465     THR H   185                                                      
REMARK 465     THR H   186                                                      
REMARK 465     GLN H   187                                                      
REMARK 465     VAL H   188                                                      
REMARK 465     PRO H   189                                                      
REMARK 465     ASN H   190                                                      
REMARK 465     HIS H   191                                                      
REMARK 465     SER H   192                                                      
REMARK 465     LEU H   193                                                      
REMARK 465     SER H   194                                                      
REMARK 465     HIS H   195                                                      
REMARK 465     ARG H   196                                                      
REMARK 465     GLN H   197                                                      
REMARK 465     PRO H   198                                                      
REMARK 465     GLU H   199                                                      
REMARK 465     THR H   200                                                      
REMARK 465     VAL H   201                                                      
REMARK 465     LEU H   202                                                      
REMARK 465     THR H   203                                                      
REMARK 465     GLU H   204                                                      
REMARK 465     THR H   205                                                      
REMARK 465     PRO H   206                                                      
REMARK 465     GLN H   207                                                      
REMARK 465     ASP H   208                                                      
REMARK 465     THR H   209                                                      
REMARK 465     ILE H   210                                                      
REMARK 465     GLU H   211                                                      
REMARK 465     LEU H   212                                                      
REMARK 465     ASN H   213                                                      
REMARK 465     ARG H   214                                                      
REMARK 465     LEU H   215                                                      
REMARK 465     ASN H   216                                                      
REMARK 465     LEU H   217                                                      
REMARK 465     GLU H   218                                                      
REMARK 465     SER H   219                                                      
REMARK 465     SER H   220                                                      
REMARK 465     ASN H   221                                                      
REMARK 465     SER H   222                                                      
REMARK 465     LYS H   223                                                      
REMARK 465     TYR H   224                                                      
REMARK 465     SER H   225                                                      
REMARK 465     LEU H   226                                                      
REMARK 465     ASN H   227                                                      
REMARK 465     THR H   228                                                      
REMARK 465     ASP H   229                                                      
REMARK 465     SER H   230                                                      
REMARK 465     SER H   231                                                      
REMARK 465     VAL H   232                                                      
REMARK 465     SER H   233                                                      
REMARK 465     TYR H   234                                                      
REMARK 465     ILE H   235                                                      
REMARK 465     ASP H   236                                                      
REMARK 465     SER H   237                                                      
REMARK 465     ALA H   238                                                      
REMARK 465     VAL H   239                                                      
REMARK 465     ILE H   240                                                      
REMARK 465     SER H   241                                                      
REMARK 465     PRO H   242                                                      
REMARK 465     ASP H   243                                                      
REMARK 465     THR H   244                                                      
REMARK 465     VAL H   245                                                      
REMARK 465     PRO H   246                                                      
REMARK 465     LEU H   247                                                      
REMARK 465     GLY H   248                                                      
REMARK 465     THR H   249                                                      
REMARK 465     GLY H   250                                                      
REMARK 465     THR H   251                                                      
REMARK 465     SER H   252                                                      
REMARK 465     ILE H   253                                                      
REMARK 465     LEU H   254                                                      
REMARK 465     SER H   255                                                      
REMARK 465     LYS H   256                                                      
REMARK 465     GLN H   257                                                      
REMARK 465     VAL H   258                                                      
REMARK 465     GLN H   259                                                      
REMARK 465     ASN H   260                                                      
REMARK 465     LYS H   261                                                      
REMARK 465     PRO H   262                                                      
REMARK 465     LYS H   263                                                      
REMARK 465     THR H   264                                                      
REMARK 465     GLY H   265                                                      
REMARK 465     ARG H   266                                                      
REMARK 465     SER H   267                                                      
REMARK 465     LEU H   268                                                      
REMARK 465     LEU H   269                                                      
REMARK 465     GLY H   270                                                      
REMARK 465     GLY H   271                                                      
REMARK 465     PRO H   272                                                      
REMARK 465     ALA H   273                                                      
REMARK 465     ALA H   274                                                      
REMARK 465     LEU H   275                                                      
REMARK 465     SER H   276                                                      
REMARK 465     PRO H   277                                                      
REMARK 465     LEU H   278                                                      
REMARK 465     THR H   279                                                      
REMARK 465     PRO H   280                                                      
REMARK 465     SER H   281                                                      
REMARK 465     PHE H   282                                                      
REMARK 465     GLY H   283                                                      
REMARK 465     ILE H   284                                                      
REMARK 465     LEU H   285                                                      
REMARK 465     PRO H   286                                                      
REMARK 465     LEU H   287                                                      
REMARK 465     GLU H   288                                                      
REMARK 465     THR H   289                                                      
REMARK 465     PRO H   290                                                      
REMARK 465     SER H   291                                                      
REMARK 465     PRO H   292                                                      
REMARK 465     GLY H   293                                                      
REMARK 465     ASP H   294                                                      
REMARK 465     GLY H   295                                                      
REMARK 465     SER H   296                                                      
REMARK 465     TYR H   297                                                      
REMARK 465     LEU H   298                                                      
REMARK 465     GLN H   299                                                      
REMARK 465     ASN H   300                                                      
REMARK 465     TYR H   301                                                      
REMARK 465     THR H   302                                                      
REMARK 465     ASN H   303                                                      
REMARK 465     THR H   304                                                      
REMARK 465     PRO H   305                                                      
REMARK 465     PRO H   306                                                      
REMARK 465     VAL H   307                                                      
REMARK 465     ILE H   308                                                      
REMARK 465     ASP H   309                                                      
REMARK 465     VAL H   310                                                      
REMARK 465     PRO H   311                                                      
REMARK 465     SER H   312                                                      
REMARK 465     THR H   313                                                      
REMARK 465     GLY H   314                                                      
REMARK 465     ALA H   315                                                      
REMARK 465     PRO H   316                                                      
REMARK 465     SER H   317                                                      
REMARK 465     LYS H   318                                                      
REMARK 465     LYS H   319                                                      
REMARK 465     SER H   320                                                      
REMARK 465     VAL H   321                                                      
REMARK 465     ALA H   322                                                      
REMARK 465     ARG H   323                                                      
REMARK 465     ILE H   324                                                      
REMARK 465     GLY H   325                                                      
REMARK 465     GLN H   326                                                      
REMARK 465     THR H   327                                                      
REMARK 465     GLY H   328                                                      
REMARK 465     THR H   329                                                      
REMARK 465     LYS H   330                                                      
REMARK 465     SER H   331                                                      
REMARK 465     VAL H   332                                                      
REMARK 465     PHE H   333                                                      
REMARK 465     SER H   334                                                      
REMARK 465     GLN H   335                                                      
REMARK 465     SER H   336                                                      
REMARK 465     GLY H   337                                                      
REMARK 465     ASN H   338                                                      
REMARK 465     SER H   339                                                      
REMARK 465     ARG H   340                                                      
REMARK 465     GLU H   341                                                      
REMARK 465     VAL H   342                                                      
REMARK 465     THR H   343                                                      
REMARK 465     PRO H   344                                                      
REMARK 465     ILE H   345                                                      
REMARK 465     LEU H   346                                                      
REMARK 465     ALA H   347                                                      
REMARK 465     GLN H   348                                                      
REMARK 465     THR H   349                                                      
REMARK 465     GLN H   350                                                      
REMARK 465     SER H   351                                                      
REMARK 465     SER H   352                                                      
REMARK 465     GLY H   353                                                      
REMARK 465     PRO H   354                                                      
REMARK 465     GLN H   355                                                      
REMARK 465     THR H   356                                                      
REMARK 465     SER H   357                                                      
REMARK 465     THR H   358                                                      
REMARK 465     THR H   359                                                      
REMARK 465     PRO H   360                                                      
REMARK 465     GLN H   361                                                      
REMARK 465     VAL H   362                                                      
REMARK 465     LEU H   363                                                      
REMARK 465     SER H   364                                                      
REMARK 465     PRO H   365                                                      
REMARK 465     THR H   366                                                      
REMARK 465     ILE H   367                                                      
REMARK 465     THR H   368                                                      
REMARK 465     SER H   369                                                      
REMARK 465     PRO H   370                                                      
REMARK 465     PRO H   371                                                      
REMARK 465     ASN H   372                                                      
REMARK 465     ALA H   373                                                      
REMARK 465     LEU H   374                                                      
REMARK 465     PRO H   375                                                      
REMARK 465     ARG H   376                                                      
REMARK 465     ARG H   377                                                      
REMARK 465     SER H   378                                                      
REMARK 465     SER H   379                                                      
REMARK 465     ARG H   380                                                      
REMARK 465     LEU H   381                                                      
REMARK 465     PHE H   382                                                      
REMARK 465     THR H   383                                                      
REMARK 465     SER H   384                                                      
REMARK 465     ASP H   385                                                      
REMARK 465     SER H   386                                                      
REMARK 465     SER H   387                                                      
REMARK 465     THR H   388                                                      
REMARK 465     THR H   389                                                      
REMARK 465     LYS H   390                                                      
REMARK 465     GLU H   391                                                      
REMARK 465     ASN H   392                                                      
REMARK 465     SER H   393                                                      
REMARK 465     LYS H   394                                                      
REMARK 465     LYS H   395                                                      
REMARK 465     LEU H   396                                                      
REMARK 465     LYS H   397                                                      
REMARK 465     MET H   398                                                      
REMARK 465     LYS H   399                                                      
REMARK 465     PHE H   400                                                      
REMARK 465     PRO H   401                                                      
REMARK 465     PRO H   402                                                      
REMARK 465     LYS H   403                                                      
REMARK 465     ILE H   404                                                      
REMARK 465     PRO H   405                                                      
REMARK 465     ASN H   406                                                      
REMARK 465     ARG H   407                                                      
REMARK 465     LYS H   408                                                      
REMARK 465     THR H   409                                                      
REMARK 465     LYS H   410                                                      
REMARK 465     SER H   411                                                      
REMARK 465     LYS H   412                                                      
REMARK 465     THR H   413                                                      
REMARK 465     ASN H   414                                                      
REMARK 465     LYS H   415                                                      
REMARK 465     GLY H   416                                                      
REMARK 465     GLY H   417                                                      
REMARK 465     ILE H   418                                                      
REMARK 465     THR H   419                                                      
REMARK 465     GLN H   420                                                      
REMARK 465     PRO H   421                                                      
REMARK 465     ASN H   422                                                      
REMARK 465     ILE H   423                                                      
REMARK 465     ASN H   424                                                      
REMARK 465     ASP H   425                                                      
REMARK 465     SER H   426                                                      
REMARK 465     LEU H   427                                                      
REMARK 465     GLU H   428                                                      
REMARK 465     ILE H   429                                                      
REMARK 465     THR H   430                                                      
REMARK 465     LYS H   431                                                      
REMARK 465     LEU H   432                                                      
REMARK 465     ASP H   433                                                      
REMARK 465     SER H   434                                                      
REMARK 465     SER H   435                                                      
REMARK 465     ILE H   436                                                      
REMARK 465     ILE H   437                                                      
REMARK 465     SER H   438                                                      
REMARK 465     GLU H   439                                                      
REMARK 465     GLY H   440                                                      
REMARK 465     LYS H   441                                                      
REMARK 465     ILE H   442                                                      
REMARK 465     SER H   443                                                      
REMARK 465     THR H   444                                                      
REMARK 465     ILE H   445                                                      
REMARK 465     THR H   446                                                      
REMARK 465     PRO H   447                                                      
REMARK 465     GLN H   448                                                      
REMARK 465     ILE H   449                                                      
REMARK 465     GLN H   450                                                      
REMARK 465     PRO H   772                                                      
REMARK 465     LYS H   773                                                      
REMARK 465     GLY H   774                                                      
REMARK 465     ALA H   775                                                      
REMARK 465     ASN H   776                                                      
REMARK 465     ASN H   777                                                      
REMARK 465     GLN H   778                                                      
REMARK 465     ILE H   779                                                      
REMARK 465     LYS H   780                                                      
REMARK 465     GLU H   781                                                      
REMARK 465     ALA H   782                                                      
REMARK 465     ILE H   783                                                      
REMARK 465     ASP H   784                                                      
REMARK 465     LYS H   785                                                      
REMARK 465     ARG H   786                                                      
REMARK 465     TYR H   787                                                      
REMARK 465     LEU H   788                                                      
REMARK 465     PRO H   789                                                      
REMARK 465     ASP H   790                                                      
REMARK 465     ASP H   791                                                      
REMARK 465     GLU H   792                                                      
REMARK 465     GLU H   793                                                      
REMARK 465     PRO H   794                                                      
REMARK 465     ILE H   795                                                      
REMARK 465     THR H   796                                                      
REMARK 465     GLN H   797                                                      
REMARK 465     GLU H   798                                                      
REMARK 465     GLU H   799                                                      
REMARK 465     GLN H   800                                                      
REMARK 465     ILE H   801                                                      
REMARK 465     MET H   802                                                      
REMARK 465     GLY H   803                                                      
REMARK 465     THR H   804                                                      
REMARK 465     ASP H   805                                                      
REMARK 465     GLU H   806                                                      
REMARK 465     SER H   807                                                      
REMARK 465     GLN H   808                                                      
REMARK 465     GLU H   809                                                      
REMARK 465     SER H   810                                                      
REMARK 465     SER H   811                                                      
REMARK 465     MET H   812                                                      
REMARK 465     THR H   813                                                      
REMARK 465     ASP H   814                                                      
REMARK 465     ALA H   815                                                      
REMARK 465     ASP H   816                                                      
REMARK 465     ASP H   817                                                      
REMARK 465     THR H   818                                                      
REMARK 465     GLN H   819                                                      
REMARK 465     LEU H   820                                                      
REMARK 465     HIS H   821                                                      
REMARK 465     ALA H   822                                                      
REMARK 465     ALA H   823                                                      
REMARK 465     GLU H   824                                                      
REMARK 465     SER H   825                                                      
REMARK 465     ASP H   826                                                      
REMARK 465     GLU H   827                                                      
REMARK 465     PHE H   828                                                      
REMARK 465     MET I     1                                                      
REMARK 465     LEU I     2                                                      
REMARK 465     ARG I     3                                                      
REMARK 465     PHE I     4                                                      
REMARK 465     PRO I     5                                                      
REMARK 465     THR I     6                                                      
REMARK 465     CYS I     7                                                      
REMARK 465     PHE I     8                                                      
REMARK 465     ASN I   130                                                      
REMARK 465     ALA I   131                                                      
REMARK 465     ASP I   431                                                      
REMARK 465     HIS I   432                                                      
REMARK 465     VAL I   433                                                      
REMARK 465     LEU I   434                                                      
REMARK 465     PRO I   435                                                      
REMARK 465     GLU I   436                                                      
REMARK 465     LEU I   437                                                      
REMARK 465     ASN I   438                                                      
REMARK 465     ASN I   457                                                      
REMARK 465     GLU I   458                                                      
REMARK 465     ALA I   459                                                      
REMARK 465     PRO I   460                                                      
REMARK 465     ASP I   461                                                      
REMARK 465     LEU I   462                                                      
REMARK 465     TYR I   463                                                      
REMARK 465     ASN I   464                                                      
REMARK 465     ARG I   465                                                      
REMARK 465     LYS I   466                                                      
REMARK 465     GLY I   467                                                      
REMARK 465     LYS I   468                                                      
REMARK 465     TYR I   469                                                      
REMARK 465     GLU I   751                                                      
REMARK 465     TRP I   752                                                      
REMARK 465     GLU I   753                                                      
REMARK 465     LEU I   754                                                      
REMARK 465     ASP I   755                                                      
REMARK 465     GLU I   756                                                      
REMARK 465     SER I   757                                                      
REMARK 465     SER I   758                                                      
REMARK 465     ASP I   759                                                      
REMARK 465     GLU I   760                                                      
REMARK 465     GLU I   761                                                      
REMARK 465     GLU I   762                                                      
REMARK 465     GLU I   763                                                      
REMARK 465     ALA I   764                                                      
REMARK 465     SER I   765                                                      
REMARK 465     ASN I   766                                                      
REMARK 465     LYS I   767                                                      
REMARK 465     PRO I   768                                                      
REMARK 465     VAL I   769                                                      
REMARK 465     LYS I   770                                                      
REMARK 465     ILE I   771                                                      
REMARK 465     LYS I   772                                                      
REMARK 465     GLU I   773                                                      
REMARK 465     GLU I   774                                                      
REMARK 465     VAL I   775                                                      
REMARK 465     LEU I   776                                                      
REMARK 465     SER I   777                                                      
REMARK 465     GLU I   778                                                      
REMARK 465     SER I   779                                                      
REMARK 465     GLU I   780                                                      
REMARK 465     ALA I   781                                                      
REMARK 465     GLU I   782                                                      
REMARK 465     ASN I   783                                                      
REMARK 465     GLN I   784                                                      
REMARK 465     GLN I   785                                                      
REMARK 465     ALA I   786                                                      
REMARK 465     GLY I   787                                                      
REMARK 465     ALA I   788                                                      
REMARK 465     ALA I   789                                                      
REMARK 465     ALA I   790                                                      
REMARK 465     LEU I   791                                                      
REMARK 465     ALA I   792                                                      
REMARK 465     PRO I   793                                                      
REMARK 465     GLU I   794                                                      
REMARK 465     ILE I   795                                                      
REMARK 465     VAL I   796                                                      
REMARK 465     ILE I   797                                                      
REMARK 465     LYS I   798                                                      
REMARK 465     VAL I   799                                                      
REMARK 465     GLU I   800                                                      
REMARK 465     LYS I   801                                                      
REMARK 465     LEU I   802                                                      
REMARK 465     ASP I   803                                                      
REMARK 465     PRO I   804                                                      
REMARK 465     GLU I   805                                                      
REMARK 465     LEU I   806                                                      
REMARK 465     ASP I   807                                                      
REMARK 465     SER I   808                                                      
REMARK 465     GLY I   809                                                      
REMARK 465     GLY I   810                                                      
REMARK 465     SER I   811                                                      
REMARK 465     LEU I   812                                                      
REMARK 465     GLU I   813                                                      
REMARK 465     VAL I   814                                                      
REMARK 465     LEU I   815                                                      
REMARK 465     PHE I   816                                                      
REMARK 465     GLN I   817                                                      
REMARK 465     GLY I   818                                                      
REMARK 465     MET J     1                                                      
REMARK 465     MET J    95                                                      
REMARK 465     GLU J    96                                                      
REMARK 465     GLU J    97                                                      
REMARK 465     PRO J    98                                                      
REMARK 465     ILE J    99                                                      
REMARK 465     ASN J   100                                                      
REMARK 465     LYS J   101                                                      
REMARK 465     ARG J   102                                                      
REMARK 465     LEU J   103                                                      
REMARK 465     PHE J   104                                                      
REMARK 465     GLU J   105                                                      
REMARK 465     LYS J   106                                                      
REMARK 465     TYR J   107                                                      
REMARK 465     LEU J   108                                                      
REMARK 465     LYS J   109                                                      
REMARK 465     ASP J   110                                                      
REMARK 465     GLU J   111                                                      
REMARK 465     SER J   112                                                      
REMARK 465     GLY J   113                                                      
REMARK 465     PHE J   114                                                      
REMARK 465     LYS J   115                                                      
REMARK 465     ASP J   116                                                      
REMARK 465     PRO J   117                                                      
REMARK 465     SER J   118                                                      
REMARK 465     SER J   119                                                      
REMARK 465     ASP J   120                                                      
REMARK 465     TRP J   121                                                      
REMARK 465     GLU J   122                                                      
REMARK 465     ASP J   529                                                      
REMARK 465     SER J   530                                                      
REMARK 465     GLU J   531                                                      
REMARK 465     ALA J   532                                                      
REMARK 465     TYR J   533                                                      
REMARK 465     ILE J   534                                                      
REMARK 465     GLY J   535                                                      
REMARK 465     ALA J   536                                                      
REMARK 465     ASP J   537                                                      
REMARK 465     ILE J   538                                                      
REMARK 465     LYS J   539                                                      
REMARK 465     ASP J   540                                                      
REMARK 465     LYS J   541                                                      
REMARK 465     LEU J   542                                                      
REMARK 465     LYS J   543                                                      
REMARK 465     CYS J   544                                                      
REMARK 465     TYR J   545                                                      
REMARK 465     ASP J   546                                                      
REMARK 465     PHE J   547                                                      
REMARK 465     ASP J   548                                                      
REMARK 465     VAL J   549                                                      
REMARK 465     HIS J   550                                                      
REMARK 465     THR J   551                                                      
REMARK 465     MET J   552                                                      
REMARK 465     LYS J   553                                                      
REMARK 465     THR J   554                                                      
REMARK 465     LEU J   555                                                      
REMARK 465     LYS J   556                                                      
REMARK 465     ASN J   557                                                      
REMARK 465     ILE J   558                                                      
REMARK 465     ILE J   559                                                      
REMARK 465     SER J   560                                                      
REMARK 465     PRO J   561                                                      
REMARK 465     PRO J   562                                                      
REMARK 465     TRP J   563                                                      
REMARK 465     ASP J   564                                                      
REMARK 465     PHE J   565                                                      
REMARK 465     ARG J   566                                                      
REMARK 465     GLU J   567                                                      
REMARK 465     PHE J   568                                                      
REMARK 465     GLU J   569                                                      
REMARK 465     VAL J   570                                                      
REMARK 465     GLU J   571                                                      
REMARK 465     LYS J   572                                                      
REMARK 465     GLN J   573                                                      
REMARK 465     THR J   574                                                      
REMARK 465     ALA J   575                                                      
REMARK 465     GLU J   576                                                      
REMARK 465     GLU J   577                                                      
REMARK 465     THR J   578                                                      
REMARK 465     GLY J   579                                                      
REMARK 465     LEU J   580                                                      
REMARK 465     THR J   581                                                      
REMARK 465     PRO J   582                                                      
REMARK 465     LEU J   583                                                      
REMARK 465     GLU J   584                                                      
REMARK 465     THR J   585                                                      
REMARK 465     SER J   586                                                      
REMARK 465     ARG J   587                                                      
REMARK 465     LYS J   588                                                      
REMARK 465     THR J   589                                                      
REMARK 465     PRO J   590                                                      
REMARK 465     ASP J   591                                                      
REMARK 465     SER J   592                                                      
REMARK 465     ARG J   593                                                      
REMARK 465     PRO J   594                                                      
REMARK 465     SER J   595                                                      
REMARK 465     LEU J   596                                                      
REMARK 465     GLU J   597                                                      
REMARK 465     GLU J   598                                                      
REMARK 465     THR J   599                                                      
REMARK 465     PHE J   600                                                      
REMARK 465     GLU J   601                                                      
REMARK 465     ILE J   602                                                      
REMARK 465     GLU J   603                                                      
REMARK 465     MET J   604                                                      
REMARK 465     ASN J   605                                                      
REMARK 465     GLU J   606                                                      
REMARK 465     SER J   607                                                      
REMARK 465     ASP J   608                                                      
REMARK 465     MET J   609                                                      
REMARK 465     MET J   610                                                      
REMARK 465     LEU J   611                                                      
REMARK 465     GLU J   612                                                      
REMARK 465     THR J   613                                                      
REMARK 465     SER J   614                                                      
REMARK 465     MET J   615                                                      
REMARK 465     SER J   616                                                      
REMARK 465     ASP J   617                                                      
REMARK 465     HIS J   618                                                      
REMARK 465     SER J   619                                                      
REMARK 465     THR J   620                                                      
REMARK 465     MET K     1                                                      
REMARK 465     ASP K    94                                                      
REMARK 465     MET K    95                                                      
REMARK 465     GLU K    96                                                      
REMARK 465     GLU K    97                                                      
REMARK 465     PRO K    98                                                      
REMARK 465     ILE K    99                                                      
REMARK 465     ASN K   100                                                      
REMARK 465     LYS K   101                                                      
REMARK 465     ARG K   102                                                      
REMARK 465     LEU K   103                                                      
REMARK 465     PHE K   104                                                      
REMARK 465     GLU K   105                                                      
REMARK 465     LYS K   106                                                      
REMARK 465     TYR K   107                                                      
REMARK 465     LEU K   108                                                      
REMARK 465     LYS K   109                                                      
REMARK 465     ASP K   110                                                      
REMARK 465     GLU K   111                                                      
REMARK 465     SER K   112                                                      
REMARK 465     GLY K   113                                                      
REMARK 465     PHE K   114                                                      
REMARK 465     LYS K   115                                                      
REMARK 465     ASP K   116                                                      
REMARK 465     PRO K   117                                                      
REMARK 465     SER K   118                                                      
REMARK 465     SER K   119                                                      
REMARK 465     ASP K   120                                                      
REMARK 465     TRP K   121                                                      
REMARK 465     GLU K   122                                                      
REMARK 465     MET K   123                                                      
REMARK 465     SER K   124                                                      
REMARK 465     GLN K   125                                                      
REMARK 465     SER K   126                                                      
REMARK 465     GLY K   528                                                      
REMARK 465     ASP K   529                                                      
REMARK 465     SER K   530                                                      
REMARK 465     GLU K   531                                                      
REMARK 465     ALA K   532                                                      
REMARK 465     TYR K   533                                                      
REMARK 465     ILE K   534                                                      
REMARK 465     GLY K   535                                                      
REMARK 465     ALA K   536                                                      
REMARK 465     ASP K   537                                                      
REMARK 465     ILE K   538                                                      
REMARK 465     LYS K   539                                                      
REMARK 465     ASP K   540                                                      
REMARK 465     LYS K   541                                                      
REMARK 465     LEU K   542                                                      
REMARK 465     LYS K   543                                                      
REMARK 465     CYS K   544                                                      
REMARK 465     TYR K   545                                                      
REMARK 465     ASP K   546                                                      
REMARK 465     PHE K   547                                                      
REMARK 465     ASP K   548                                                      
REMARK 465     VAL K   549                                                      
REMARK 465     HIS K   550                                                      
REMARK 465     THR K   551                                                      
REMARK 465     MET K   552                                                      
REMARK 465     LYS K   553                                                      
REMARK 465     THR K   554                                                      
REMARK 465     LEU K   555                                                      
REMARK 465     LYS K   556                                                      
REMARK 465     ASN K   557                                                      
REMARK 465     ILE K   558                                                      
REMARK 465     ILE K   559                                                      
REMARK 465     SER K   560                                                      
REMARK 465     PRO K   561                                                      
REMARK 465     PRO K   562                                                      
REMARK 465     TRP K   563                                                      
REMARK 465     ASP K   564                                                      
REMARK 465     PHE K   565                                                      
REMARK 465     ARG K   566                                                      
REMARK 465     GLU K   567                                                      
REMARK 465     PHE K   568                                                      
REMARK 465     GLU K   569                                                      
REMARK 465     VAL K   570                                                      
REMARK 465     GLU K   571                                                      
REMARK 465     LYS K   572                                                      
REMARK 465     GLN K   573                                                      
REMARK 465     THR K   574                                                      
REMARK 465     ALA K   575                                                      
REMARK 465     GLU K   576                                                      
REMARK 465     GLU K   577                                                      
REMARK 465     THR K   578                                                      
REMARK 465     GLY K   579                                                      
REMARK 465     LEU K   580                                                      
REMARK 465     THR K   581                                                      
REMARK 465     PRO K   582                                                      
REMARK 465     LEU K   583                                                      
REMARK 465     GLU K   584                                                      
REMARK 465     THR K   585                                                      
REMARK 465     SER K   586                                                      
REMARK 465     ARG K   587                                                      
REMARK 465     LYS K   588                                                      
REMARK 465     THR K   589                                                      
REMARK 465     PRO K   590                                                      
REMARK 465     ASP K   591                                                      
REMARK 465     SER K   592                                                      
REMARK 465     ARG K   593                                                      
REMARK 465     PRO K   594                                                      
REMARK 465     SER K   595                                                      
REMARK 465     LEU K   596                                                      
REMARK 465     GLU K   597                                                      
REMARK 465     GLU K   598                                                      
REMARK 465     THR K   599                                                      
REMARK 465     PHE K   600                                                      
REMARK 465     GLU K   601                                                      
REMARK 465     ILE K   602                                                      
REMARK 465     GLU K   603                                                      
REMARK 465     MET K   604                                                      
REMARK 465     ASN K   605                                                      
REMARK 465     GLU K   606                                                      
REMARK 465     SER K   607                                                      
REMARK 465     ASP K   608                                                      
REMARK 465     MET K   609                                                      
REMARK 465     MET K   610                                                      
REMARK 465     LEU K   611                                                      
REMARK 465     GLU K   612                                                      
REMARK 465     THR K   613                                                      
REMARK 465     SER K   614                                                      
REMARK 465     MET K   615                                                      
REMARK 465     SER K   616                                                      
REMARK 465     ASP K   617                                                      
REMARK 465     HIS K   618                                                      
REMARK 465     SER K   619                                                      
REMARK 465     THR K   620                                                      
REMARK 465     MET L     1                                                      
REMARK 465     THR L     2                                                      
REMARK 465     GLU L   162A                                                     
REMARK 465     GLU L   162B                                                     
REMARK 465     SER L   162C                                                     
REMARK 465     SER L   162D                                                     
REMARK 465     ILE L   162E                                                     
REMARK 465     GLY L   162F                                                     
REMARK 465     LYS L   162G                                                     
REMARK 465     LEU M    33                                                      
REMARK 465     ASN M    34                                                      
REMARK 465     GLU M    35                                                      
REMARK 465     LEU M    36                                                      
REMARK 465     PRO M    37                                                      
REMARK 465     GLU M    38                                                      
REMARK 465     PRO M    39                                                      
REMARK 465     GLU M    40                                                      
REMARK 465     GLN M    41                                                      
REMARK 465     ASP M    42                                                      
REMARK 465     ASN M    43                                                      
REMARK 465     GLY M    44                                                      
REMARK 465     GLY M    45                                                      
REMARK 465     THR M    46                                                      
REMARK 465     THR M    47                                                      
REMARK 465     GLU M    48                                                      
REMARK 465     SER M    49                                                      
REMARK 465     VAL M    50                                                      
REMARK 465     ASN M    68                                                      
REMARK 465     VAL M    69                                                      
REMARK 465     PRO M    70                                                      
REMARK 465     PRO M    71                                                      
REMARK 465     ILE M    72                                                      
REMARK 465     GLY M    73                                                      
REMARK 465     ASN M    74                                                      
REMARK 465     MET N     1                                                      
REMARK 465     ALA N     2                                                      
REMARK 465     ALA N     3                                                      
REMARK 465     ALA N     4                                                      
REMARK 465     VAL N     5                                                      
REMARK 465     VAL N     6                                                      
REMARK 465     VAL N     7                                                      
REMARK 465     ALA N     8                                                      
REMARK 465     GLU N     9                                                      
REMARK 465     GLY N    10                                                      
REMARK 465     ASP N    11                                                      
REMARK 465     SER N    12                                                      
REMARK 465     ASP N    13                                                      
REMARK 465     SER N    14                                                      
REMARK 465     ARG N    15                                                      
REMARK 465     PRO N    16                                                      
REMARK 465     GLY N    17                                                      
REMARK 465     GLN N    18                                                      
REMARK 465     GLU N    19                                                      
REMARK 465     LEU N    20                                                      
REMARK 465     GLY N    30                                                      
REMARK 465     LEU N    31                                                      
REMARK 465     VAL N    32                                                      
REMARK 465     PRO N    33                                                      
REMARK 465     PRO N    34                                                      
REMARK 465     ALA N    35                                                      
REMARK 465     ALA N    36                                                      
REMARK 465     LEU N    37                                                      
REMARK 465     GLY N    38                                                      
REMARK 465     LEU N    39                                                      
REMARK 465     VAL N    40                                                      
REMARK 465     SER N    41                                                      
REMARK 465     SER N    42                                                      
REMARK 465     ARG N    43                                                      
REMARK 465     THR N    44                                                      
REMARK 465     SER N    45                                                      
REMARK 465     GLY N    46                                                      
REMARK 465     ALA N    47                                                      
REMARK 465     VAL N    48                                                      
REMARK 465     PRO N    49                                                      
REMARK 465     PRO N    50                                                      
REMARK 465     LYS N    51                                                      
REMARK 465     GLU N    52                                                      
REMARK 465     GLU N    53                                                      
REMARK 465     GLU N    54                                                      
REMARK 465     LEU N    55                                                      
REMARK 465     ARG N    56                                                      
REMARK 465     ALA N    57                                                      
REMARK 465     ALA N    58                                                      
REMARK 465     VAL N    59                                                      
REMARK 465     GLU N    60                                                      
REMARK 465     VAL N    61                                                      
REMARK 465     LEU N    62                                                      
REMARK 465     ARG N    63                                                      
REMARK 465     GLY N    64                                                      
REMARK 465     HIS N    65                                                      
REMARK 465     GLY N    66                                                      
REMARK 465     LEU N    67                                                      
REMARK 465     HIS N    68                                                      
REMARK 465     SER N    69                                                      
REMARK 465     VAL N    70                                                      
REMARK 465     LEU N    71                                                      
REMARK 465     ALA N   102                                                      
REMARK 465     ASP N   103                                                      
REMARK 465     GLU N   104                                                      
REMARK 465     PRO N   105                                                      
REMARK 465     GLN N   106                                                      
REMARK 465     LEU N   140A                                                     
REMARK 465     MET N   140B                                                     
REMARK 465     GLY N   140C                                                     
REMARK 465     THR N   140D                                                     
REMARK 465     GLY N   140E                                                     
REMARK 465     ALA N   140F                                                     
REMARK 465     GLN N   140G                                                     
REMARK 465     GLY N   140H                                                     
REMARK 465     GLY N   191                                                      
REMARK 465     GLU N   192                                                      
REMARK 465     GLY N   193                                                      
REMARK 465     GLY N   194                                                      
REMARK 465     THR N   195                                                      
REMARK 465     ASP N   196                                                      
REMARK 465     PRO N   197                                                      
REMARK 465     GLU N   198                                                      
REMARK 465     LEU N   199                                                      
REMARK 465     GLU N   200                                                      
REMARK 465     GLY N   201                                                      
REMARK 465     GLU N   202                                                      
REMARK 465     LEU N   203                                                      
REMARK 465     ASP N   204                                                      
REMARK 465     SER N   205                                                      
REMARK 465     ARG N   206                                                      
REMARK 465     TYR N   207                                                      
REMARK 465     ALA N   208                                                      
REMARK 465     ARG N   209                                                      
REMARK 465     ARG N   210                                                      
REMARK 465     ARG N   211                                                      
REMARK 465     TYR N   212                                                      
REMARK 465     TYR N   213                                                      
REMARK 465     ARG N   214                                                      
REMARK 465     LEU N   215                                                      
REMARK 465     LEU N   216                                                      
REMARK 465     GLN N   217                                                      
REMARK 465     SER N   218                                                      
REMARK 465     PRO N   219                                                      
REMARK 465     LEU N   220                                                      
REMARK 465     CYS N   221                                                      
REMARK 465     ALA N   222                                                      
REMARK 465     GLY N   223                                                      
REMARK 465     CYS N   224                                                      
REMARK 465     SER N   225                                                      
REMARK 465     SER N   226                                                      
REMARK 465     ASP N   227                                                      
REMARK 465     LYS N   228                                                      
REMARK 465     GLN N   229                                                      
REMARK 465     GLN N   230                                                      
REMARK 465     CYS N   231                                                      
REMARK 465     LEU N   250                                                      
REMARK 465     SER N   251                                                      
REMARK 465     LEU N   252                                                      
REMARK 465     LEU N   253                                                      
REMARK 465     GLU N   254                                                      
REMARK 465     ARG N   255                                                      
REMARK 465     VAL N   256                                                      
REMARK 465     LEU N   305                                                      
REMARK 465     GLN N   306                                                      
REMARK 465     ASP N   307                                                      
REMARK 465     GLY N   308                                                      
REMARK 465     PRO N   309                                                      
REMARK 465     ALA N   310                                                      
REMARK 465     ARG N   311                                                      
REMARK 465     PRO N   312                                                      
REMARK 465     ALA N   313                                                      
REMARK 465     SER N   314                                                      
REMARK 465     PRO N   315                                                      
REMARK 465     GLU N   316                                                      
REMARK 465     ALA N   317                                                      
REMARK 465     GLY N   318                                                      
REMARK 465     ASN N   319                                                      
REMARK 465     GLY N   444                                                      
REMARK 465     ASP N   445                                                      
REMARK 465     SER N   446                                                      
REMARK 465     ASP N   447                                                      
REMARK 465     GLY N   448                                                      
REMARK 465     THR N   449                                                      
REMARK 465     GLY N   450                                                      
REMARK 465     THR N   459                                                      
REMARK 465     ASP N   460                                                      
REMARK 465     PRO N   461                                                      
REMARK 465     ALA N   462                                                      
REMARK 465     SER N   463                                                      
REMARK 465     LEU N   464                                                      
REMARK 465     GLU N   465                                                      
REMARK 465     THR N   466                                                      
REMARK 465     GLY N   467                                                      
REMARK 465     GLN N   468                                                      
REMARK 465     ASP N   469                                                      
REMARK 465     SER N   470                                                      
REMARK 465     GLU N   471                                                      
REMARK 465     ASP N   472                                                      
REMARK 465     ASP N   473                                                      
REMARK 465     SER N   474                                                      
REMARK 465     GLY N   475                                                      
REMARK 465     GLU N   476                                                      
REMARK 465     PRO N   477                                                      
REMARK 465     GLU N   478                                                      
REMARK 465     ASP N   479                                                      
REMARK 465     TRP N   480                                                      
REMARK 465     VAL N   481                                                      
REMARK 465     PRO N   482                                                      
REMARK 465     ASP N   483                                                      
REMARK 465     PRO N   484                                                      
REMARK 465     SER N   492                                                      
REMARK 465     SER N   493                                                      
REMARK 465     SER N   494                                                      
REMARK 465     LYS N   495                                                      
REMARK 465     ARG N   496                                                      
REMARK 465     ARG N   497                                                      
REMARK 465     SER N   498                                                      
REMARK 465     GLY N   510                                                      
REMARK 465     SER N   511                                                      
REMARK 465     LYS N   512                                                      
REMARK 465     ASP N   513                                                      
REMARK 465     PRO N   721                                                      
REMARK 465     GLN N   722                                                      
REMARK 465     ASP N   723                                                      
REMARK 465     ARG N   724                                                      
REMARK 465     ASP N   725                                                      
REMARK 465     ASN N   726                                                      
REMARK 465     MET N   727                                                      
REMARK 465     VAL N   728                                                      
REMARK 465     LEU N   729                                                      
REMARK 465     ILE N   730                                                      
REMARK 465     ASP N   731                                                      
REMARK 465     SER N   732                                                      
REMARK 465     ASP N   733                                                      
REMARK 465     ASP N   734                                                      
REMARK 465     GLU N   735                                                      
REMARK 465     SER N   736                                                      
REMARK 465     ASP N   737                                                      
REMARK 465     SER N   738                                                      
REMARK 465     GLY N   739                                                      
REMARK 465     MET N   740                                                      
REMARK 465     ALA N   741                                                      
REMARK 465     SER N   742                                                      
REMARK 465     GLN N   743                                                      
REMARK 465     ALA N   744                                                      
REMARK 465     ASP N   745                                                      
REMARK 465     GLN N   746                                                      
REMARK 465     LYS N   819                                                      
REMARK 465     ASN N   820                                                      
REMARK 465     CYS N   821                                                      
REMARK 465     SER N   822                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     SER O     3                                                      
REMARK 465     VAL O     4                                                      
REMARK 465     HIS O     5                                                      
REMARK 465     GLU O     6                                                      
REMARK 465     SER O     7                                                      
REMARK 465     LEU O     8                                                      
REMARK 465     TYR O     9                                                      
REMARK 465     PHE O    10                                                      
REMARK 465     ASN O    11                                                      
REMARK 465     PRO O    12                                                      
REMARK 465     MET O    13                                                      
REMARK 465     MET O    14                                                      
REMARK 465     THR O    15                                                      
REMARK 465     ASN O    16                                                      
REMARK 465     GLY O    17                                                      
REMARK 465     VAL O    18                                                      
REMARK 465     VAL O    19                                                      
REMARK 465     HIS O    20                                                      
REMARK 465     ALA O    21                                                      
REMARK 465     ASN O    22                                                      
REMARK 465     VAL O    23                                                      
REMARK 465     PHE O    24                                                      
REMARK 465     GLY O    25                                                      
REMARK 465     ILE O    26                                                      
REMARK 465     VAL O   170                                                      
REMARK 465     GLU O   171                                                      
REMARK 465     ASP O   172                                                      
REMARK 465     ALA O   173                                                      
REMARK 465     ASP O   174                                                      
REMARK 465     MET O   175                                                      
REMARK 465     GLU O   176                                                      
REMARK 465     LEU O   177                                                      
REMARK 465     THR O   178                                                      
REMARK 465     SER O   179                                                      
REMARK 465     ARG O   180                                                      
REMARK 465     ASP O   181                                                      
REMARK 465     GLU O   182                                                      
REMARK 465     GLY O   183                                                      
REMARK 465     GLU O   184                                                      
REMARK 465     ARG O   185                                                      
REMARK 465     LYS O   186                                                      
REMARK 465     MET O   187                                                      
REMARK 465     GLU O   188                                                      
REMARK 465     LYS O   189                                                      
REMARK 465     GLU O   190                                                      
REMARK 465     GLU O   191                                                      
REMARK 465     LEU O   192                                                      
REMARK 465     ASP O   193                                                      
REMARK 465     VAL O   194                                                      
REMARK 465     SER O   195                                                      
REMARK 465     VAL O   196                                                      
REMARK 465     ARG O   197                                                      
REMARK 465     GLU O   198                                                      
REMARK 465     GLU O   199                                                      
REMARK 465     GLU O   200                                                      
REMARK 465     VAL O   201                                                      
REMARK 465     SER O   202                                                      
REMARK 465     CYS O   203                                                      
REMARK 465     SER O   204                                                      
REMARK 465     GLY O   205                                                      
REMARK 465     ALA O   453                                                      
REMARK 465     VAL O   454                                                      
REMARK 465     ASN O   455                                                      
REMARK 465     ALA O   456                                                      
REMARK 465     GLY O   457                                                      
REMARK 465     VAL O   458                                                      
REMARK 465     PRO O   745                                                      
REMARK 465     SER O   746                                                      
REMARK 465     HIS O   747                                                      
REMARK 465     GLY O   748                                                      
REMARK 465     VAL O   749                                                      
REMARK 465     PRO O   750                                                      
REMARK 465     LEU O   751                                                      
REMARK 465     ILE O   752                                                      
REMARK 465     ASN O   753                                                      
REMARK 465     HIS O   754                                                      
REMARK 465     LEU O   755                                                      
REMARK 465     MET P     1                                                      
REMARK 465     ALA P     2                                                      
REMARK 465     ALA P     3                                                      
REMARK 465     SER P     4                                                      
REMARK 465     THR P     5                                                      
REMARK 465     SER P     6                                                      
REMARK 465     MET P     7                                                      
REMARK 465     VAL P     8                                                      
REMARK 465     PRO P     9                                                      
REMARK 465     VAL P    10                                                      
REMARK 465     ALA P    11                                                      
REMARK 465     VAL P    12                                                      
REMARK 465     THR P    13                                                      
REMARK 465     ALA P    14                                                      
REMARK 465     ALA P    15                                                      
REMARK 465     VAL P    16                                                      
REMARK 465     ALA P    17                                                      
REMARK 465     PRO P    18                                                      
REMARK 465     VAL P    19                                                      
REMARK 465     LEU P    20                                                      
REMARK 465     SER P    21                                                      
REMARK 465     ILE P    22                                                      
REMARK 465     ASN P    23                                                      
REMARK 465     SER P    24                                                      
REMARK 465     ASP P    25                                                      
REMARK 465     VAL P   135                                                      
REMARK 465     ASP P   136                                                      
REMARK 465     SER P   137                                                      
REMARK 465     LEU P   138                                                      
REMARK 465     GLY P   139                                                      
REMARK 465     PRO P   140                                                      
REMARK 465     LEU P   141                                                      
REMARK 465     GLU P   142                                                      
REMARK 465     LYS P   143                                                      
REMARK 465     GLY P   144                                                      
REMARK 465     GLN P   145                                                      
REMARK 465     VAL P   146                                                      
REMARK 465     GLY P   463                                                      
REMARK 465     ASP P   464                                                      
REMARK 465     VAL P   465                                                      
REMARK 465     GLU P   466                                                      
REMARK 465     LYS P   467                                                      
REMARK 465     MET P   468                                                      
REMARK 465     ALA P   469                                                      
REMARK 465     LEU P   470                                                      
REMARK 465     VAL P   471                                                      
REMARK 465     LYS P   472                                                      
REMARK 465     LEU P   473                                                      
REMARK 465     ALA P   474                                                      
REMARK 465     LYS P   475                                                      
REMARK 465     LEU P   476                                                      
REMARK 465     HIS P   477                                                      
REMARK 465     GLU P   478                                                      
REMARK 465     GLN P   479                                                      
REMARK 465     LEU P   480                                                      
REMARK 465     THR P   481                                                      
REMARK 465     GLU P   482                                                      
REMARK 465     SER P   483                                                      
REMARK 465     GLU P   484                                                      
REMARK 465     GLN P   485                                                      
REMARK 465     ALA P   486                                                      
REMARK 465     ALA P   487                                                      
REMARK 465     GLN P   488                                                      
REMARK 465     CYS P   489                                                      
REMARK 465     TYR P   490                                                      
REMARK 465     ILE P   491                                                      
REMARK 465     LYS P   492                                                      
REMARK 465     TYR P   493                                                      
REMARK 465     ILE P   494                                                      
REMARK 465     GLN P   495                                                      
REMARK 465     ASP P   496                                                      
REMARK 465     ILE P   497                                                      
REMARK 465     TYR P   498                                                      
REMARK 465     SER P   499                                                      
REMARK 465     CYS P   500                                                      
REMARK 465     GLY P   501                                                      
REMARK 465     GLU P   502                                                      
REMARK 465     ILE P   503                                                      
REMARK 465     VAL P   504                                                      
REMARK 465     GLU P   505                                                      
REMARK 465     HIS P   506                                                      
REMARK 465     LEU P   507                                                      
REMARK 465     GLU P   508                                                      
REMARK 465     GLU P   509                                                      
REMARK 465     SER P   510                                                      
REMARK 465     THR P   511                                                      
REMARK 465     ALA P   512                                                      
REMARK 465     PHE P   513                                                      
REMARK 465     ARG P   514                                                      
REMARK 465     TYR P   515                                                      
REMARK 465     LEU P   516                                                      
REMARK 465     ALA P   517                                                      
REMARK 465     GLN P   518                                                      
REMARK 465     TYR P   519                                                      
REMARK 465     TYR P   520                                                      
REMARK 465     PHE P   521                                                      
REMARK 465     LYS P   522                                                      
REMARK 465     CYS P   523                                                      
REMARK 465     LYS P   524                                                      
REMARK 465     LEU P   525                                                      
REMARK 465     TRP P   526                                                      
REMARK 465     ASP P   527                                                      
REMARK 465     GLU P   528                                                      
REMARK 465     ALA P   529                                                      
REMARK 465     SER P   530                                                      
REMARK 465     THR P   531                                                      
REMARK 465     CYS P   532                                                      
REMARK 465     ALA P   533                                                      
REMARK 465     GLN P   534                                                      
REMARK 465     LYS P   535                                                      
REMARK 465     CYS P   536                                                      
REMARK 465     CYS P   537                                                      
REMARK 465     ALA P   538                                                      
REMARK 465     PHE P   539                                                      
REMARK 465     ASN P   540                                                      
REMARK 465     ASP P   541                                                      
REMARK 465     THR P   542                                                      
REMARK 465     ARG P   543                                                      
REMARK 465     GLU P   544                                                      
REMARK 465     GLU P   545                                                      
REMARK 465     GLY P   546                                                      
REMARK 465     LYS P   547                                                      
REMARK 465     ALA P   548                                                      
REMARK 465     LEU P   549                                                      
REMARK 465     LEU P   550                                                      
REMARK 465     ARG P   551                                                      
REMARK 465     GLN P   552                                                      
REMARK 465     ILE P   553                                                      
REMARK 465     LEU P   554                                                      
REMARK 465     GLN P   555                                                      
REMARK 465     LEU P   556                                                      
REMARK 465     ARG P   557                                                      
REMARK 465     ASN P   558                                                      
REMARK 465     GLN P   559                                                      
REMARK 465     GLY P   560                                                      
REMARK 465     GLU P   561                                                      
REMARK 465     THR P   562                                                      
REMARK 465     PRO P   563                                                      
REMARK 465     THR P   564                                                      
REMARK 465     THR P   565                                                      
REMARK 465     GLU P   566                                                      
REMARK 465     VAL P   567                                                      
REMARK 465     PRO P   568                                                      
REMARK 465     ALA P   569                                                      
REMARK 465     PRO P   570                                                      
REMARK 465     PHE P   571                                                      
REMARK 465     PHE P   572                                                      
REMARK 465     LEU P   573                                                      
REMARK 465     PRO P   574                                                      
REMARK 465     ALA P   575                                                      
REMARK 465     SER P   576                                                      
REMARK 465     LEU P   577                                                      
REMARK 465     SER P   578                                                      
REMARK 465     ALA P   579                                                      
REMARK 465     ASN P   580                                                      
REMARK 465     ASN P   581                                                      
REMARK 465     THR P   582                                                      
REMARK 465     PRO P   583                                                      
REMARK 465     THR P   584                                                      
REMARK 465     ARG P   585                                                      
REMARK 465     ARG P   586                                                      
REMARK 465     VAL P   587                                                      
REMARK 465     SER P   588                                                      
REMARK 465     PRO P   589                                                      
REMARK 465     LEU P   590                                                      
REMARK 465     ASN P   591                                                      
REMARK 465     LEU P   592                                                      
REMARK 465     SER P   593                                                      
REMARK 465     SER P   594                                                      
REMARK 465     VAL P   595                                                      
REMARK 465     THR P   596                                                      
REMARK 465     PRO P   597                                                      
REMARK 465     MET R     1                                                      
REMARK 465     ASP R     2                                                      
REMARK 465     GLN R     3                                                      
REMARK 465     ASP R     4                                                      
REMARK 465     TYR R     5                                                      
REMARK 465     GLU R     6                                                      
REMARK 465     ARG R     7                                                      
REMARK 465     ARG R     8                                                      
REMARK 465     LEU R     9                                                      
REMARK 465     LEU R    10                                                      
REMARK 465     ARG R    11                                                      
REMARK 465     GLN R    12                                                      
REMARK 465     ILE R    13                                                      
REMARK 465     VAL R    14                                                      
REMARK 465     ILE R    15                                                      
REMARK 465     GLN R    16                                                      
REMARK 465     ASN R    17                                                      
REMARK 465     GLU R    18                                                      
REMARK 465     ASN R    19                                                      
REMARK 465     THR R    20                                                      
REMARK 465     MET R    21                                                      
REMARK 465     PRO R    22                                                      
REMARK 465     ARG R    23                                                      
REMARK 465     VAL R    24                                                      
REMARK 465     THR R    25                                                      
REMARK 465     GLU R    26                                                      
REMARK 465     MET R    27                                                      
REMARK 465     ARG R    28                                                      
REMARK 465     ARG R    29                                                      
REMARK 465     THR R    30                                                      
REMARK 465     LEU R    31                                                      
REMARK 465     THR R    32                                                      
REMARK 465     PRO R    33                                                      
REMARK 465     ALA R    34                                                      
REMARK 465     SER R    35                                                      
REMARK 465     SER R    36                                                      
REMARK 465     PRO R    37                                                      
REMARK 465     VAL R    38                                                      
REMARK 465     SER R    39                                                      
REMARK 465     SER R    40                                                      
REMARK 465     PRO R    41                                                      
REMARK 465     GLU R    68                                                      
REMARK 465     LYS R    69                                                      
REMARK 465     SER R    70                                                      
REMARK 465     PRO R    71                                                      
REMARK 465     SER R    72                                                      
REMARK 465     GLN R    73                                                      
REMARK 465     ASN R    74                                                      
REMARK 465     ARG R    75                                                      
REMARK 465     LYS R    76                                                      
REMARK 465     ALA R    77                                                      
REMARK 465     LYS R    78                                                      
REMARK 465     ASP R    79                                                      
REMARK 465     ALA R    80                                                      
REMARK 465     THR R    81                                                      
REMARK 465     SER R    82                                                      
REMARK 465     ASP R    83                                                      
REMARK 465     ASN R    84                                                      
REMARK 465     GLY R    85                                                      
REMARK 465     LYS R    86                                                      
REMARK 465     ASP R    87                                                      
REMARK 465     ASP R   109                                                      
REMARK 465     PRO R   110                                                      
REMARK 465     GLN R   111                                                      
REMARK 465     THR R   112                                                      
REMARK 465     GLU R   113                                                      
REMARK 465     ASP R   114                                                      
REMARK 465     ARG R   115                                                      
REMARK 465     ARG R   116                                                      
REMARK 465     LEU R   117                                                      
REMARK 465     GLN R   118                                                      
REMARK 465     PRO R   119                                                      
REMARK 465     SER R   120                                                      
REMARK 465     THR R   121                                                      
REMARK 465     PRO R   122                                                      
REMARK 465     GLU R   123                                                      
REMARK 465     LYS R   124                                                      
REMARK 465     SER R   133                                                      
REMARK 465     THR R   134                                                      
REMARK 465     LYS R   135                                                      
REMARK 465     ARG R   136                                                      
REMARK 465     SER R   137                                                      
REMARK 465     SER R   138                                                      
REMARK 465     PRO R   139                                                      
REMARK 465     ASP R   140                                                      
REMARK 465     ASP R   141                                                      
REMARK 465     GLY R   142                                                      
REMARK 465     ASN R   143                                                      
REMARK 465     ASP R   144                                                      
REMARK 465     VAL R   145                                                      
REMARK 465     PRO R   164                                                      
REMARK 465     ARG R   165                                                      
REMARK 465     LYS R   166                                                      
REMARK 465     PRO R   167                                                      
REMARK 465     THR R   168                                                      
REMARK 465     ARG R   169                                                      
REMARK 465     LYS R   170                                                      
REMARK 465     ILE R   171                                                      
REMARK 465     PHE R   473                                                      
REMARK 465     SER R   474                                                      
REMARK 465     LYS R   475                                                      
REMARK 465     THR R   476                                                      
REMARK 465     ARG R   477                                                      
REMARK 465     SER R   478                                                      
REMARK 465     THR R   479                                                      
REMARK 465     LYS R   480                                                      
REMARK 465     GLU R   481                                                      
REMARK 465     SER R   482                                                      
REMARK 465     GLY S   743                                                      
REMARK 465     SER S   744                                                      
REMARK 465     ARG S   745                                                      
REMARK 465     GLU S   746                                                      
REMARK 465     ASN S   747                                                      
REMARK 465     GLU S   748                                                      
REMARK 465     LEU S   749                                                      
REMARK 465     SER S   750                                                      
REMARK 465     ALA S   751                                                      
REMARK 465     GLY S   752                                                      
REMARK 465     LEU S   753                                                      
REMARK 465     SER S   754                                                      
REMARK 465     LYS S   755                                                      
REMARK 465     ARG S   756                                                      
REMARK 465     LYS S   757                                                      
REMARK 465     HIS S   758                                                      
REMARK 465     ARG S   759                                                      
REMARK 465     GLY S   760                                                      
REMARK 465     SER S   761                                                      
REMARK 465     GLY S   762                                                      
REMARK 465     SER S   763                                                      
REMARK 465     GLY S   764                                                      
REMARK 465     SER S   765                                                      
REMARK 465     GLY S   766                                                      
REMARK 465     SER S   767                                                      
REMARK 465     ILE S   768                                                      
REMARK 465     SER S   769                                                      
REMARK 465     GLY S   770                                                      
REMARK 465     VAL S   771                                                      
REMARK 465     SER S   772                                                      
REMARK 465     THR S   773                                                      
REMARK 465     ASN S   774                                                      
REMARK 465     GLU S   809                                                      
REMARK 465     GLY S   810                                                      
REMARK 465     PRO S   811                                                      
REMARK 465     GLU S   812                                                      
REMARK 465     TYR S   813                                                      
REMARK 465     PRO S   814                                                      
REMARK 465     THR S   815                                                      
REMARK 465     LYS S   816                                                      
REMARK 465     ILE S   817                                                      
REMARK 465     GLU S   818                                                      
REMARK 465     CYS S   819                                                      
REMARK 465     TYR S   820                                                      
REMARK 465     LEU S   821                                                      
REMARK 465     GLU S   822                                                      
REMARK 465     GLU S   823                                                      
REMARK 465     GLN S   824                                                      
REMARK 465     LYS S   825                                                      
REMARK 465     PRO S   826                                                      
REMARK 465     LYS S   827                                                      
REMARK 465     PHE S   838                                                      
REMARK 465     ASN S   839                                                      
REMARK 465     LYS S   840                                                      
REMARK 465     MET S   841                                                      
REMARK 465     ASN S   842                                                      
REMARK 465     SER S   843                                                      
REMARK 465     GLY S   844                                                      
REMARK 465     SER S   845                                                      
REMARK 465     SER S   846                                                      
REMARK 465     GLY S   847                                                      
REMARK 465     SER S   848                                                      
REMARK 465     GLY S   849                                                      
REMARK 465     SER S   850                                                      
REMARK 465     SER S   851                                                      
REMARK 465     GLY S   852                                                      
REMARK 465     PRO S   926                                                      
REMARK 465     GLY S   927                                                      
REMARK 465     LYS S   928                                                      
REMARK 465     MET S   929                                                      
REMARK 465     LYS S   930                                                      
REMARK 465     SEC U    -1                                                      
REMARK 465     ASX U     0                                                      
REMARK 465     MET U     1                                                      
REMARK 465     ALA U     2                                                      
REMARK 465     SER U     3                                                      
REMARK 465     GLN U     4                                                      
REMARK 465     ASN U     5                                                      
REMARK 465     ARG U     6                                                      
REMARK 465     ASP U     7                                                      
REMARK 465     PRO U     8                                                      
REMARK 465     ALA U     9                                                      
REMARK 465     ALA U    10                                                      
REMARK 465     THR U    11                                                      
REMARK 465     SER U    12                                                      
REMARK 465     VAL U    13                                                      
REMARK 465     ALA U    14                                                      
REMARK 465     ALA U    15                                                      
REMARK 465     ALA U    16                                                      
REMARK 465     ARG U    17                                                      
REMARK 465     LYS U    18                                                      
REMARK 465     GLY U    19                                                      
REMARK 465     ALA U    20                                                      
REMARK 465     GLU U    21                                                      
REMARK 465     PRO U    22                                                      
REMARK 465     SER U    23                                                      
REMARK 465     GLY U    24                                                      
REMARK 465     GLY U    25                                                      
REMARK 465     ALA U    26                                                      
REMARK 465     ALA U    27                                                      
REMARK 465     ARG U    28                                                      
REMARK 465     VAL U   174                                                      
REMARK 465     THR U   175                                                      
REMARK 465     SER U   176                                                      
REMARK 465     GLN U   177                                                      
REMARK 465     GLU U   178                                                      
REMARK 465     PRO U   179                                                      
REMARK 465     TRP U   180                                                      
REMARK 465     SER U   181                                                      
REMARK 465     HIS U   182                                                      
REMARK 465     PRO U   183                                                      
REMARK 465     GLN U   184                                                      
REMARK 465     GLU U   185                                                      
REMARK 465     LYS U   186                                                      
REMARK 465     LEU W    26                                                      
REMARK 465     GLU W    27                                                      
REMARK 465     THR W    28                                                      
REMARK 465     ARG W    29                                                      
REMARK 465     LYS W    30                                                      
REMARK 465     LYS W    31                                                      
REMARK 465     GLN W    32                                                      
REMARK 465     LYS W    33                                                      
REMARK 465     GLU W    34                                                      
REMARK 465     ASP W    35                                                      
REMARK 465     VAL W    36                                                      
REMARK 465     GLU W    37                                                      
REMARK 465     VAL W    38                                                      
REMARK 465     VAL W    39                                                      
REMARK 465     GLY W    40                                                      
REMARK 465     GLY W    41                                                      
REMARK 465     SER W    42                                                      
REMARK 465     ASP W    43                                                      
REMARK 465     GLY W    44                                                      
REMARK 465     GLU W    45                                                      
REMARK 465     GLY W    46                                                      
REMARK 465     ALA W    47                                                      
REMARK 465     ILE W    48                                                      
REMARK 465     GLY W    49                                                      
REMARK 465     LEU W    50                                                      
REMARK 465     SER W    51                                                      
REMARK 465     SER W    52                                                      
REMARK 465     ASP W    53                                                      
REMARK 465     PRO W    54                                                      
REMARK 465     LYS W    55                                                      
REMARK 465     SER W    56                                                      
REMARK 465     ARG W    57                                                      
REMARK 465     GLU W    58                                                      
REMARK 465     GLN W    59                                                      
REMARK 465     MET W    60                                                      
REMARK 465     ILE W    61                                                      
REMARK 465     ASN W    62                                                      
REMARK 465     ASP W    63                                                      
REMARK 465     ARG W    64                                                      
REMARK 465     ILE W    65                                                      
REMARK 465     GLY W    66                                                      
REMARK 465     TYR W    67                                                      
REMARK 465     LYS W    68                                                      
REMARK 465     PRO W    69                                                      
REMARK 465     GLN W    70                                                      
REMARK 465     PRO W    71                                                      
REMARK 465     LYS W    72                                                      
REMARK 465     PRO W    73                                                      
REMARK 465     ASN W    74                                                      
REMARK 465     ASN W    75                                                      
REMARK 465     ARG W    76                                                      
REMARK 465     SER W    77                                                      
REMARK 465     SER W    78                                                      
REMARK 465     GLN W    79                                                      
REMARK 465     PHE W    80                                                      
REMARK 465     GLY W    81                                                      
REMARK 465     SER W    82                                                      
REMARK 465     LEU W    83                                                      
REMARK 465     GLU W    84                                                      
REMARK 465     PHE W    85                                                      
REMARK 465     MET X    35                                                      
REMARK 465     SER X   111                                                      
REMARK 465     LYS X   112                                                      
REMARK 465     THR X   113                                                      
REMARK 465     SER X   114                                                      
REMARK 465     LYS X   115                                                      
REMARK 465     VAL X   116                                                      
REMARK 465     ARG X   117                                                      
REMARK 465     PRO X   118                                                      
REMARK 465     SER X   119                                                      
REMARK 465     THR X   120                                                      
REMARK 465     GLY X   121                                                      
REMARK 465     ASN X   122                                                      
REMARK 465     SER X   123                                                      
REMARK 465     ALA X   124                                                      
REMARK 465     SER X   125                                                      
REMARK 465     THR X   126                                                      
REMARK 465     PRO X   127                                                      
REMARK 465     GLN X   128                                                      
REMARK 465     SER X   129                                                      
REMARK 465     GLN X   130                                                      
REMARK 465     CYS X   131                                                      
REMARK 465     LEU X   437                                                      
REMARK 465     GLY X   438                                                      
REMARK 465     ALA X   439                                                      
REMARK 465     ASN X   440                                                      
REMARK 465     ALA X   441                                                      
REMARK 465     GLN X   442                                                      
REMARK 465     THR X   443                                                      
REMARK 465     LEU X   444                                                      
REMARK 465     THR X   445                                                      
REMARK 465     LEU X   446                                                      
REMARK 465     LEU X   447                                                      
REMARK 465     ALA X   448                                                      
REMARK 465     THR X   449                                                      
REMARK 465     VAL X   450                                                      
REMARK 465     CYS X   451                                                      
REMARK 465     LEU X   452                                                      
REMARK 465     GLU X   453                                                      
REMARK 465     ASP X   454                                                      
REMARK 465     PRO X   455                                                      
REMARK 465     VAL X   456                                                      
REMARK 465     THR X   457                                                      
REMARK 465     GLN X   458                                                      
REMARK 465     GLU X   459                                                      
REMARK 465     LYS X   460                                                      
REMARK 465     ALA X   461                                                      
REMARK 465     LYS X   462                                                      
REMARK 465     THR X   463                                                      
REMARK 465     LEU X   464                                                      
REMARK 465     LEU X   465                                                      
REMARK 465     ASP X   466                                                      
REMARK 465     LYS X   467                                                      
REMARK 465     ALA X   468                                                      
REMARK 465     LEU X   469                                                      
REMARK 465     THR X   470                                                      
REMARK 465     GLN X   471                                                      
REMARK 465     ARG X   472                                                      
REMARK 465     PRO X   473                                                      
REMARK 465     ASP X   474                                                      
REMARK 465     TYR X   475                                                      
REMARK 465     ILE X   476                                                      
REMARK 465     LYS X   477                                                      
REMARK 465     ALA X   478                                                      
REMARK 465     VAL X   479                                                      
REMARK 465     VAL X   480                                                      
REMARK 465     LYS X   481                                                      
REMARK 465     LYS X   482                                                      
REMARK 465     ALA X   483                                                      
REMARK 465     GLU X   484                                                      
REMARK 465     LEU X   485                                                      
REMARK 465     LEU X   486                                                      
REMARK 465     SER X   487                                                      
REMARK 465     ARG X   488                                                      
REMARK 465     GLU X   489                                                      
REMARK 465     GLN X   490                                                      
REMARK 465     LYS X   491                                                      
REMARK 465     TYR X   492                                                      
REMARK 465     GLU X   493                                                      
REMARK 465     ASP X   494                                                      
REMARK 465     GLY X   495                                                      
REMARK 465     ILE X   496                                                      
REMARK 465     ALA X   497                                                      
REMARK 465     LEU X   498                                                      
REMARK 465     LEU X   499                                                      
REMARK 465     ARG X   500                                                      
REMARK 465     ASN X   501                                                      
REMARK 465     ALA X   502                                                      
REMARK 465     LEU X   503                                                      
REMARK 465     ALA X   504                                                      
REMARK 465     ASN X   505                                                      
REMARK 465     GLN X   506                                                      
REMARK 465     SER X   507                                                      
REMARK 465     ASP X   508                                                      
REMARK 465     CYS X   509                                                      
REMARK 465     VAL X   510                                                      
REMARK 465     LEU X   511                                                      
REMARK 465     HIS X   512                                                      
REMARK 465     ARG X   513                                                      
REMARK 465     ILE X   514                                                      
REMARK 465     LEU X   515                                                      
REMARK 465     GLY X   516                                                      
REMARK 465     ASP X   517                                                      
REMARK 465     PHE X   518                                                      
REMARK 465     LEU X   519                                                      
REMARK 465     VAL X   520                                                      
REMARK 465     ALA X   521                                                      
REMARK 465     VAL X   522                                                      
REMARK 465     ASN X   523                                                      
REMARK 465     GLU X   524                                                      
REMARK 465     TYR X   525                                                      
REMARK 465     GLN X   526                                                      
REMARK 465     GLU X   527                                                      
REMARK 465     ALA X   528                                                      
REMARK 465     MET X   529                                                      
REMARK 465     ASP X   530                                                      
REMARK 465     GLN X   531                                                      
REMARK 465     TYR X   532                                                      
REMARK 465     SER X   533                                                      
REMARK 465     ILE X   534                                                      
REMARK 465     ALA X   535                                                      
REMARK 465     LEU X   536                                                      
REMARK 465     SER X   537                                                      
REMARK 465     LEU X   538                                                      
REMARK 465     ASP X   539                                                      
REMARK 465     PRO X   540                                                      
REMARK 465     ASN X   541                                                      
REMARK 465     ASP X   542                                                      
REMARK 465     GLN X   543                                                      
REMARK 465     LYS X   544                                                      
REMARK 465     SER X   545                                                      
REMARK 465     LEU X   546                                                      
REMARK 465     GLU X   547                                                      
REMARK 465     GLY X   548                                                      
REMARK 465     MET X   549                                                      
REMARK 465     GLN X   550                                                      
REMARK 465     LYS X   551                                                      
REMARK 465     MET X   552                                                      
REMARK 465     GLU X   553                                                      
REMARK 465     LYS X   554                                                      
REMARK 465     GLU X   555                                                      
REMARK 465     GLU X   556                                                      
REMARK 465     SER X   557                                                      
REMARK 465     PRO X   558                                                      
REMARK 465     THR X   559                                                      
REMARK 465     ASP X   560                                                      
REMARK 465     ALA X   561                                                      
REMARK 465     THR X   562                                                      
REMARK 465     GLN X   563                                                      
REMARK 465     GLU X   564                                                      
REMARK 465     GLU X   565                                                      
REMARK 465     ASP X   566                                                      
REMARK 465     VAL X   567                                                      
REMARK 465     ASP X   568                                                      
REMARK 465     ASP X   569                                                      
REMARK 465     MET X   570                                                      
REMARK 465     GLU X   571                                                      
REMARK 465     GLY X   572                                                      
REMARK 465     SER X   573                                                      
REMARK 465     GLY X   574                                                      
REMARK 465     GLU X   575                                                      
REMARK 465     GLU X   576                                                      
REMARK 465     GLY X   577                                                      
REMARK 465     ASP X   578                                                      
REMARK 465     LEU X   579                                                      
REMARK 465     GLU X   580                                                      
REMARK 465     GLY X   581                                                      
REMARK 465     SER X   582                                                      
REMARK 465     ASP X   583                                                      
REMARK 465     SER X   584                                                      
REMARK 465     GLU X   585                                                      
REMARK 465     ALA X   586                                                      
REMARK 465     ALA X   587                                                      
REMARK 465     GLN X   588                                                      
REMARK 465     TRP X   589                                                      
REMARK 465     ALA X   590                                                      
REMARK 465     ASP X   591                                                      
REMARK 465     GLN X   592                                                      
REMARK 465     GLU X   593                                                      
REMARK 465     GLN X   594                                                      
REMARK 465     TRP X   595                                                      
REMARK 465     PHE X   596                                                      
REMARK 465     GLY X   597                                                      
REMARK 465     MET X   598                                                      
REMARK 465     GLN X   599                                                      
REMARK 465     MET Y    35                                                      
REMARK 465     SER Y   111                                                      
REMARK 465     LYS Y   112                                                      
REMARK 465     THR Y   113                                                      
REMARK 465     SER Y   114                                                      
REMARK 465     LYS Y   115                                                      
REMARK 465     VAL Y   116                                                      
REMARK 465     ARG Y   117                                                      
REMARK 465     PRO Y   118                                                      
REMARK 465     SER Y   119                                                      
REMARK 465     THR Y   120                                                      
REMARK 465     GLY Y   121                                                      
REMARK 465     ASN Y   122                                                      
REMARK 465     SER Y   123                                                      
REMARK 465     ALA Y   124                                                      
REMARK 465     SER Y   125                                                      
REMARK 465     THR Y   126                                                      
REMARK 465     PRO Y   127                                                      
REMARK 465     GLN Y   128                                                      
REMARK 465     SER Y   129                                                      
REMARK 465     GLN Y   130                                                      
REMARK 465     CYS Y   131                                                      
REMARK 465     VAL Y   456                                                      
REMARK 465     THR Y   457                                                      
REMARK 465     GLN Y   458                                                      
REMARK 465     GLU Y   459                                                      
REMARK 465     LYS Y   460                                                      
REMARK 465     ALA Y   461                                                      
REMARK 465     LYS Y   462                                                      
REMARK 465     THR Y   463                                                      
REMARK 465     LEU Y   464                                                      
REMARK 465     LEU Y   465                                                      
REMARK 465     ASP Y   466                                                      
REMARK 465     LYS Y   467                                                      
REMARK 465     ALA Y   468                                                      
REMARK 465     LEU Y   469                                                      
REMARK 465     THR Y   470                                                      
REMARK 465     GLN Y   471                                                      
REMARK 465     ARG Y   472                                                      
REMARK 465     PRO Y   473                                                      
REMARK 465     ASP Y   474                                                      
REMARK 465     TYR Y   475                                                      
REMARK 465     ILE Y   476                                                      
REMARK 465     LYS Y   477                                                      
REMARK 465     ALA Y   478                                                      
REMARK 465     VAL Y   479                                                      
REMARK 465     VAL Y   480                                                      
REMARK 465     LYS Y   481                                                      
REMARK 465     LYS Y   482                                                      
REMARK 465     ALA Y   483                                                      
REMARK 465     GLU Y   484                                                      
REMARK 465     LEU Y   485                                                      
REMARK 465     LEU Y   486                                                      
REMARK 465     SER Y   487                                                      
REMARK 465     ARG Y   488                                                      
REMARK 465     GLU Y   489                                                      
REMARK 465     GLN Y   490                                                      
REMARK 465     LYS Y   491                                                      
REMARK 465     TYR Y   492                                                      
REMARK 465     GLU Y   493                                                      
REMARK 465     ASP Y   494                                                      
REMARK 465     GLY Y   495                                                      
REMARK 465     ILE Y   496                                                      
REMARK 465     ALA Y   497                                                      
REMARK 465     LEU Y   498                                                      
REMARK 465     LEU Y   499                                                      
REMARK 465     ARG Y   500                                                      
REMARK 465     ASN Y   501                                                      
REMARK 465     ALA Y   502                                                      
REMARK 465     LEU Y   503                                                      
REMARK 465     ALA Y   504                                                      
REMARK 465     ASN Y   505                                                      
REMARK 465     GLN Y   506                                                      
REMARK 465     SER Y   507                                                      
REMARK 465     ASP Y   508                                                      
REMARK 465     CYS Y   509                                                      
REMARK 465     VAL Y   510                                                      
REMARK 465     LEU Y   511                                                      
REMARK 465     HIS Y   512                                                      
REMARK 465     ARG Y   513                                                      
REMARK 465     ILE Y   514                                                      
REMARK 465     LEU Y   515                                                      
REMARK 465     GLY Y   516                                                      
REMARK 465     ASP Y   517                                                      
REMARK 465     PHE Y   518                                                      
REMARK 465     LEU Y   519                                                      
REMARK 465     VAL Y   520                                                      
REMARK 465     ALA Y   521                                                      
REMARK 465     VAL Y   522                                                      
REMARK 465     ASN Y   523                                                      
REMARK 465     GLU Y   524                                                      
REMARK 465     TYR Y   525                                                      
REMARK 465     GLN Y   526                                                      
REMARK 465     GLU Y   527                                                      
REMARK 465     ALA Y   528                                                      
REMARK 465     MET Y   529                                                      
REMARK 465     ASP Y   530                                                      
REMARK 465     GLN Y   531                                                      
REMARK 465     TYR Y   532                                                      
REMARK 465     SER Y   533                                                      
REMARK 465     ILE Y   534                                                      
REMARK 465     ALA Y   535                                                      
REMARK 465     LEU Y   536                                                      
REMARK 465     SER Y   537                                                      
REMARK 465     LEU Y   538                                                      
REMARK 465     ASP Y   539                                                      
REMARK 465     PRO Y   540                                                      
REMARK 465     ASN Y   541                                                      
REMARK 465     ASP Y   542                                                      
REMARK 465     GLN Y   543                                                      
REMARK 465     LYS Y   544                                                      
REMARK 465     SER Y   545                                                      
REMARK 465     LEU Y   546                                                      
REMARK 465     GLU Y   547                                                      
REMARK 465     GLY Y   548                                                      
REMARK 465     MET Y   549                                                      
REMARK 465     GLN Y   550                                                      
REMARK 465     LYS Y   551                                                      
REMARK 465     MET Y   552                                                      
REMARK 465     GLU Y   553                                                      
REMARK 465     LYS Y   554                                                      
REMARK 465     GLU Y   555                                                      
REMARK 465     GLU Y   556                                                      
REMARK 465     SER Y   557                                                      
REMARK 465     PRO Y   558                                                      
REMARK 465     THR Y   559                                                      
REMARK 465     ASP Y   560                                                      
REMARK 465     ALA Y   561                                                      
REMARK 465     THR Y   562                                                      
REMARK 465     GLN Y   563                                                      
REMARK 465     GLU Y   564                                                      
REMARK 465     GLU Y   565                                                      
REMARK 465     ASP Y   566                                                      
REMARK 465     VAL Y   567                                                      
REMARK 465     ASP Y   568                                                      
REMARK 465     ASP Y   569                                                      
REMARK 465     MET Y   570                                                      
REMARK 465     GLU Y   571                                                      
REMARK 465     GLY Y   572                                                      
REMARK 465     SER Y   573                                                      
REMARK 465     GLY Y   574                                                      
REMARK 465     GLU Y   575                                                      
REMARK 465     GLU Y   576                                                      
REMARK 465     GLY Y   577                                                      
REMARK 465     ASP Y   578                                                      
REMARK 465     LEU Y   579                                                      
REMARK 465     GLU Y   580                                                      
REMARK 465     GLY Y   581                                                      
REMARK 465     SER Y   582                                                      
REMARK 465     ASP Y   583                                                      
REMARK 465     SER Y   584                                                      
REMARK 465     GLU Y   585                                                      
REMARK 465     ALA Y   586                                                      
REMARK 465     ALA Y   587                                                      
REMARK 465     GLN Y   588                                                      
REMARK 465     TRP Y   589                                                      
REMARK 465     ALA Y   590                                                      
REMARK 465     ASP Y   591                                                      
REMARK 465     GLN Y   592                                                      
REMARK 465     GLU Y   593                                                      
REMARK 465     GLN Y   594                                                      
REMARK 465     TRP Y   595                                                      
REMARK 465     PHE Y   596                                                      
REMARK 465     GLY Y   597                                                      
REMARK 465     MET Y   598                                                      
REMARK 465     GLN Y   599                                                      
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-3432   RELATED DB: EMDB                              
DBREF  5L9U A    1  1944  UNP    Q9H1A4   APC1_HUMAN       1   1944             
DBREF  5L9U B    1    84  UNP    Q9NYG5   APC11_HUMAN      1     84             
DBREF  5L9U C    1   597  UNP    Q9UJX2   CDC23_HUMAN      1    597             
DBREF  5L9U D    1   121  UNP    P60006   APC15_HUMAN      1    121             
DBREF  5L9U E    1   110  UNP    Q96DE5   APC16_HUMAN      1    110             
DBREF  5L9U F    1   824  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  5L9U G    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  5L9U H    1   828  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  5L9U I    1   808  UNP    Q9UJX5   APC4_HUMAN       1    808             
DBREF  5L9U J    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  5L9U K    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  5L9U L    1   184  UNP    Q9UM13   APC10_HUMAN      1    185             
DBREF  5L9U M    1    74  UNP    Q9BS18   APC13_HUMAN      1     74             
DBREF  5L9U N    1   822  UNP    Q9UJX6   ANC2_HUMAN       1    822             
DBREF  5L9U O    1   755  UNP    Q9UJX4   APC5_HUMAN       1    755             
DBREF  5L9U P    1   597  UNP    Q9UJX2   CDC23_HUMAN      1    597             
DBREF  5L9U R    1   493  UNP    Q9UM11   FZR_HUMAN        1    493             
DBREF  5L9U S  743   759  PDB    5L9U     5L9U           743    759             
DBREF  5L9U S  768   842  UNP    P34244   HSL1_YEAST     768    842             
DBREF  5L9U S  853   930  UNP    Q63429   UBC_RAT          1     78             
DBREF  5L9U U    1   179  UNP    O00762   UBE2C_HUMAN      1    179             
DBREF  5L9U W    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  5L9U X   35   599  UNP    Q9UJX3   APC7_HUMAN      35    599             
DBREF  5L9U Y   35   599  UNP    Q9UJX3   APC7_HUMAN      35    599             
SEQADV 5L9U GLY I  809  UNP  Q9UJX5              EXPRESSION TAG                 
SEQADV 5L9U GLY I  810  UNP  Q9UJX5              EXPRESSION TAG                 
SEQADV 5L9U SER I  811  UNP  Q9UJX5              EXPRESSION TAG                 
SEQADV 5L9U LEU I  812  UNP  Q9UJX5              EXPRESSION TAG                 
SEQADV 5L9U GLU I  813  UNP  Q9UJX5              EXPRESSION TAG                 
SEQADV 5L9U VAL I  814  UNP  Q9UJX5              EXPRESSION TAG                 
SEQADV 5L9U LEU I  815  UNP  Q9UJX5              EXPRESSION TAG                 
SEQADV 5L9U PHE I  816  UNP  Q9UJX5              EXPRESSION TAG                 
SEQADV 5L9U GLN I  817  UNP  Q9UJX5              EXPRESSION TAG                 
SEQADV 5L9U GLY I  818  UNP  Q9UJX5              EXPRESSION TAG                 
SEQADV 5L9U GLY S  760  PDB                      LINKER                         
SEQADV 5L9U SER S  761  PDB                      LINKER                         
SEQADV 5L9U GLY S  762  PDB                      LINKER                         
SEQADV 5L9U SER S  763  PDB                      LINKER                         
SEQADV 5L9U GLY S  764  PDB                      LINKER                         
SEQADV 5L9U SER S  765  PDB                      LINKER                         
SEQADV 5L9U GLY S  766  PDB                      LINKER                         
SEQADV 5L9U SER S  767  PDB                      LINKER                         
SEQADV 5L9U     S       UNP  P34244    LYS   788 DELETION                       
SEQADV 5L9U     S       UNP  P34244    ASN   789 DELETION                       
SEQADV 5L9U     S       UNP  P34244    GLN   790 DELETION                       
SEQADV 5L9U     S       UNP  P34244    PHE   791 DELETION                       
SEQADV 5L9U     S       UNP  P34244    ASN   792 DELETION                       
SEQADV 5L9U     S       UNP  P34244    MET   793 DELETION                       
SEQADV 5L9U     S       UNP  P34244    SER   794 DELETION                       
SEQADV 5L9U     S       UNP  P34244    TYR   795 DELETION                       
SEQADV 5L9U     S       UNP  P34244    LYS   796 DELETION                       
SEQADV 5L9U     S       UNP  P34244    PRO   797 DELETION                       
SEQADV 5L9U     S       UNP  P34244    SER   798 DELETION                       
SEQADV 5L9U     S       UNP  P34244    GLU   799 DELETION                       
SEQADV 5L9U     S       UNP  P34244    ASN   800 DELETION                       
SEQADV 5L9U     S       UNP  P34244    MET   801 DELETION                       
SEQADV 5L9U     S       UNP  P34244    SER   802 DELETION                       
SEQADV 5L9U     S       UNP  P34244    GLY   803 DELETION                       
SEQADV 5L9U     S       UNP  P34244    LEU   804 DELETION                       
SEQADV 5L9U     S       UNP  P34244    SER   805 DELETION                       
SEQADV 5L9U     S       UNP  P34244    SER   806 DELETION                       
SEQADV 5L9U     S       UNP  P34244    PHE   807 DELETION                       
SEQADV 5L9U     S       UNP  P34244    PRO   808 DELETION                       
SEQADV 5L9U     S       UNP  P34244    ILE   809 DELETION                       
SEQADV 5L9U     S       UNP  P34244    PHE   810 DELETION                       
SEQADV 5L9U     S       UNP  P34244    GLU   811 DELETION                       
SEQADV 5L9U     S       UNP  P34244    LYS   812 DELETION                       
SEQADV 5L9U     S       UNP  P34244    GLU   813 DELETION                       
SEQADV 5L9U     S       UNP  P34244    ASN   814 DELETION                       
SEQADV 5L9U     S       UNP  P34244    THR   815 DELETION                       
SEQADV 5L9U     S       UNP  P34244    LEU   816 DELETION                       
SEQADV 5L9U     S       UNP  P34244    SER   817 DELETION                       
SEQADV 5L9U     S       UNP  P34244    SER   818 DELETION                       
SEQADV 5L9U CYS S  819  UNP  P34244    SER   819 ENGINEERED MUTATION            
SEQADV 5L9U SER S  843  UNP  P34244              LINKER                         
SEQADV 5L9U GLY S  844  UNP  P34244              LINKER                         
SEQADV 5L9U SER S  845  UNP  P34244              LINKER                         
SEQADV 5L9U SER S  846  UNP  P34244              LINKER                         
SEQADV 5L9U GLY S  847  UNP  P34244              LINKER                         
SEQADV 5L9U SER S  848  UNP  P34244              LINKER                         
SEQADV 5L9U GLY S  849  UNP  P34244              LINKER                         
SEQADV 5L9U SER S  850  UNP  P34244              LINKER                         
SEQADV 5L9U SER S  851  UNP  P34244              LINKER                         
SEQADV 5L9U GLY S  852  UNP  P34244              LINKER                         
SEQADV 5L9U LEU S  856  UNP  Q63429    PHE     4 ENGINEERED MUTATION            
SEQADV 5L9U PRO S  860  UNP  Q63429    LEU     8 ENGINEERED MUTATION            
SEQADV 5L9U ARG S  861  UNP  Q63429    THR     9 ENGINEERED MUTATION            
SEQADV 5L9U ILE S  894  UNP  Q63429    ARG    42 ENGINEERED MUTATION            
SEQADV 5L9U PHE S  896  UNP  Q63429    ILE    44 ENGINEERED MUTATION            
SEQADV 5L9U VAL S  899  UNP  Q63429    GLY    47 ENGINEERED MUTATION            
SEQADV 5L9U ARG S  901  UNP  Q63429    GLN    49 ENGINEERED MUTATION            
SEQADV 5L9U LYS S  916  UNP  Q63429    GLU    64 ENGINEERED MUTATION            
SEQADV 5L9U SER S  918  UNP  Q63429    THR    66 ENGINEERED MUTATION            
SEQADV 5L9U LEU S  920  UNP  Q63429    HIS    68 ENGINEERED MUTATION            
SEQADV 5L9U ALA S  922  UNP  Q63429    VAL    70 ENGINEERED MUTATION            
SEQADV 5L9U MET S  923  UNP  Q63429    LEU    71 ENGINEERED MUTATION            
SEQADV 5L9U VAL S  925  UNP  Q63429    LEU    73 ENGINEERED MUTATION            
SEQADV 5L9U PRO S  926  UNP  Q63429    ARG    74 ENGINEERED MUTATION            
SEQADV 5L9U LYS S  928  UNP  Q63429    GLY    76 ENGINEERED MUTATION            
SEQADV 5L9U LYS S  930  UNP  Q63429    GLN    78 ENGINEERED MUTATION            
SEQADV 5L9U SEC U   -1  UNP  O00762              EXPRESSION TAG                 
SEQADV 5L9U ASX U    0  UNP  O00762              EXPRESSION TAG                 
SEQADV 5L9U ALA U  102  UNP  O00762    CYS   102 ENGINEERED MUTATION            
SEQADV 5L9U TRP U  180  UNP  O00762              EXPRESSION TAG                 
SEQADV 5L9U SER U  181  UNP  O00762              EXPRESSION TAG                 
SEQADV 5L9U HIS U  182  UNP  O00762              EXPRESSION TAG                 
SEQADV 5L9U PRO U  183  UNP  O00762              EXPRESSION TAG                 
SEQADV 5L9U GLN U  184  UNP  O00762              EXPRESSION TAG                 
SEQADV 5L9U GLU U  185  UNP  O00762              EXPRESSION TAG                 
SEQADV 5L9U LYS U  186  UNP  O00762              EXPRESSION TAG                 
SEQRES   1 A 1944  MET SER ASN PHE TYR GLU GLU ARG THR THR MET ILE ALA          
SEQRES   2 A 1944  ALA ARG ASP LEU GLN GLU PHE VAL PRO PHE GLY ARG ASP          
SEQRES   3 A 1944  HIS CYS LYS HIS HIS PRO ASN ALA LEU ASN LEU GLN LEU          
SEQRES   4 A 1944  ARG GLN LEU GLN PRO ALA SER GLU LEU TRP SER SER ASP          
SEQRES   5 A 1944  GLY ALA ALA GLY LEU VAL GLY SER LEU GLN GLU VAL THR          
SEQRES   6 A 1944  ILE HIS GLU LYS GLN LYS GLU SER TRP GLN LEU ARG LYS          
SEQRES   7 A 1944  GLY VAL SER GLU ILE GLY GLU ASP VAL ASP TYR ASP GLU          
SEQRES   8 A 1944  GLU LEU TYR VAL ALA GLY ASN MET VAL ILE TRP SER LYS          
SEQRES   9 A 1944  GLY SER LYS SER GLN ALA LEU ALA VAL TYR LYS ALA PHE          
SEQRES  10 A 1944  THR VAL ASP SER PRO VAL GLN GLN ALA LEU TRP CYS ASP          
SEQRES  11 A 1944  PHE ILE ILE SER GLN ASP LYS SER GLU LYS ALA TYR SER          
SEQRES  12 A 1944  SER ASN GLU VAL GLU LYS CYS ILE CYS ILE LEU GLN SER          
SEQRES  13 A 1944  SER CYS ILE ASN MET HIS SER ILE GLU GLY LYS ASP TYR          
SEQRES  14 A 1944  ILE ALA SER LEU PRO PHE GLN VAL ALA ASN VAL TRP PRO          
SEQRES  15 A 1944  THR LYS TYR GLY LEU LEU PHE GLU ARG SER ALA SER SER          
SEQRES  16 A 1944  HIS GLU VAL PRO PRO GLY SER PRO ARG GLU PRO LEU PRO          
SEQRES  17 A 1944  THR MET PHE SER MET LEU HIS PRO LEU ASP GLU ILE THR          
SEQRES  18 A 1944  PRO LEU VAL CYS LYS SER GLY SER LEU PHE GLY SER SER          
SEQRES  19 A 1944  ARG VAL GLN TYR VAL VAL ASP HIS ALA MET LYS ILE VAL          
SEQRES  20 A 1944  PHE LEU ASN THR ASP PRO SER ILE VAL MET THR TYR ASP          
SEQRES  21 A 1944  ALA VAL GLN ASN VAL HIS SER VAL TRP THR LEU ARG ARG          
SEQRES  22 A 1944  VAL LYS SER GLU GLU GLU ASN VAL VAL LEU LYS PHE SER          
SEQRES  23 A 1944  GLU GLN GLY GLY THR PRO GLN ASN VAL ALA THR SER SER          
SEQRES  24 A 1944  SER LEU THR ALA HIS LEU ARG SER LEU SER LYS GLY ASP          
SEQRES  25 A 1944  SER PRO VAL THR SER PRO PHE GLN ASN TYR SER SER ILE          
SEQRES  26 A 1944  HIS SER GLN SER ARG SER THR SER SER PRO SER LEU HIS          
SEQRES  27 A 1944  SER ARG SER PRO SER ILE SER ASN MET ALA ALA LEU SER          
SEQRES  28 A 1944  ARG ALA HIS SER PRO ALA LEU GLY VAL HIS SER PHE SER          
SEQRES  29 A 1944  GLY VAL GLN ARG PHE ASN ILE SER SER HIS ASN GLN SER          
SEQRES  30 A 1944  PRO LYS ARG HIS SER ILE SER HIS SER PRO ASN SER ASN          
SEQRES  31 A 1944  SER ASN GLY SER PHE LEU ALA PRO GLU THR GLU PRO ILE          
SEQRES  32 A 1944  VAL PRO GLU LEU CYS ILE ASP HIS LEU TRP THR GLU THR          
SEQRES  33 A 1944  ILE THR ASN ILE ARG GLU LYS ASN SER GLN ALA SER LYS          
SEQRES  34 A 1944  VAL PHE ILE THR SER ASP LEU CYS GLY GLN LYS PHE LEU          
SEQRES  35 A 1944  CYS PHE LEU VAL GLU SER GLN LEU GLN LEU ARG CYS VAL          
SEQRES  36 A 1944  LYS PHE GLN GLU SER ASN ASP LYS THR GLN LEU ILE PHE          
SEQRES  37 A 1944  GLY SER VAL THR ASN ILE PRO ALA LYS ASP ALA ALA PRO          
SEQRES  38 A 1944  VAL GLU LYS ILE ASP THR MET LEU VAL LEU GLU GLY SER          
SEQRES  39 A 1944  GLY ASN LEU VAL LEU TYR THR GLY VAL VAL ARG VAL GLY          
SEQRES  40 A 1944  LYS VAL PHE ILE PRO GLY LEU PRO ALA PRO SER LEU THR          
SEQRES  41 A 1944  MET SER ASN THR MET PRO ARG PRO SER THR PRO LEU ASP          
SEQRES  42 A 1944  GLY VAL SER THR PRO LYS PRO LEU SER LYS LEU LEU GLY          
SEQRES  43 A 1944  SER LEU ASP GLU VAL VAL LEU LEU SER PRO VAL PRO GLU          
SEQRES  44 A 1944  LEU ARG ASP SER SER LYS LEU HIS ASP SER LEU TYR ASN          
SEQRES  45 A 1944  GLU ASP CYS THR PHE GLN GLN LEU GLY THR TYR ILE HIS          
SEQRES  46 A 1944  SER ILE ARG ASP PRO VAL HIS ASN ARG VAL THR LEU GLU          
SEQRES  47 A 1944  LEU SER ASN GLY SER MET VAL ARG ILE THR ILE PRO GLU          
SEQRES  48 A 1944  ILE ALA THR SER GLU LEU VAL GLN THR CYS LEU GLN ALA          
SEQRES  49 A 1944  ILE LYS PHE ILE LEU PRO LYS GLU ILE ALA VAL GLN MET          
SEQRES  50 A 1944  LEU VAL LYS TRP TYR ASN VAL HIS SER ALA PRO GLY GLY          
SEQRES  51 A 1944  PRO SER TYR HIS SER GLU TRP ASN LEU PHE VAL THR CYS          
SEQRES  52 A 1944  LEU MET ASN MET MET GLY TYR ASN THR ASP ARG LEU ALA          
SEQRES  53 A 1944  TRP THR ARG ASN PHE ASP PHE GLU GLY SER LEU SER PRO          
SEQRES  54 A 1944  VAL ILE ALA PRO LYS LYS ALA ARG PRO SER GLU THR GLY          
SEQRES  55 A 1944  SER ASP ASP ASP TRP GLU TYR LEU LEU ASN SER ASP TYR          
SEQRES  56 A 1944  HIS GLN ASN VAL GLU SER HIS LEU LEU ASN ARG SER LEU          
SEQRES  57 A 1944  CYS LEU SER PRO SER GLU ALA SER GLN MET LYS ASP GLU          
SEQRES  58 A 1944  ASP PHE SER GLN ASN LEU SER LEU ASP SER SER THR LEU          
SEQRES  59 A 1944  LEU PHE THR HIS ILE PRO ALA ILE PHE PHE VAL LEU HIS          
SEQRES  60 A 1944  LEU VAL TYR GLU GLU LEU LYS LEU ASN THR LEU MET GLY          
SEQRES  61 A 1944  GLU GLY ILE CYS SER LEU VAL GLU LEU LEU VAL GLN LEU          
SEQRES  62 A 1944  ALA ARG ASP LEU LYS LEU GLY PRO TYR VAL ASP HIS TYR          
SEQRES  63 A 1944  TYR ARG ASP TYR PRO THR LEU VAL ARG THR THR GLY GLN          
SEQRES  64 A 1944  VAL CYS THR ILE ASP PRO GLY GLN THR GLY PHE MET HIS          
SEQRES  65 A 1944  HIS PRO SER PHE PHE THR SER GLU PRO PRO SER ILE TYR          
SEQRES  66 A 1944  GLN TRP VAL SER SER CYS LEU LYS GLY GLU GLY MET PRO          
SEQRES  67 A 1944  PRO TYR PRO TYR LEU PRO GLY ILE CYS GLU ARG SER ARG          
SEQRES  68 A 1944  LEU VAL VAL LEU SER ILE ALA LEU TYR ILE LEU GLY ASP          
SEQRES  69 A 1944  GLU SER LEU VAL SER ASP GLU SER SER GLN TYR LEU THR          
SEQRES  70 A 1944  ARG ILE THR ILE ALA PRO GLN LYS LEU GLN VAL GLU GLN          
SEQRES  71 A 1944  GLU GLU ASN ARG PHE SER PHE ARG HIS SER THR SER VAL          
SEQRES  72 A 1944  SER SER LEU ALA GLU ARG LEU VAL VAL TRP MET THR ASN          
SEQRES  73 A 1944  VAL GLY PHE THR LEU ARG ASP LEU GLU THR LEU PRO PHE          
SEQRES  74 A 1944  GLY ILE ALA LEU PRO ILE ARG ASP ALA ILE TYR HIS CYS          
SEQRES  75 A 1944  ARG GLU GLN PRO ALA SER ASP TRP PRO GLU ALA VAL CYS          
SEQRES  76 A 1944  LEU LEU ILE GLY ARG GLN ASP LEU SER LYS GLN ALA CYS          
SEQRES  77 A 1944  GLU GLY ASN LEU PRO LYS GLY LYS SER VAL LEU SER SER          
SEQRES  78 A 1944  ASP VAL PRO SER GLY THR GLU THR GLU GLU GLU ASP ASP          
SEQRES  79 A 1944  GLY MET ASN ASP MET ASN HIS GLU VAL MET SER LEU ILE          
SEQRES  80 A 1944  TRP SER GLU ASP LEU ARG VAL GLN ASP VAL ARG ARG LEU          
SEQRES  81 A 1944  LEU GLN SER ALA HIS PRO VAL ARG VAL ASN VAL VAL GLN          
SEQRES  82 A 1944  TYR PRO GLU LEU SER ASP HIS GLU PHE ILE GLU GLU LYS          
SEQRES  83 A 1944  GLU ASN ARG LEU LEU GLN LEU CYS GLN ARG THR MET ALA          
SEQRES  84 A 1944  LEU PRO VAL GLY ARG GLY MET PHE THR LEU PHE SER TYR          
SEQRES  85 A 1944  HIS PRO VAL PRO THR GLU PRO LEU PRO ILE PRO LYS LEU          
SEQRES  86 A 1944  ASN LEU THR GLY ARG ALA PRO PRO ARG ASN THR THR VAL          
SEQRES  87 A 1944  ASP LEU ASN SER GLY ASN ILE ASP VAL PRO PRO ASN MET          
SEQRES  88 A 1944  THR SER TRP ALA SER PHE HIS ASN GLY VAL ALA ALA GLY          
SEQRES  89 A 1944  LEU LYS ILE ALA PRO ALA SER GLN ILE ASP SER ALA TRP          
SEQRES  90 A 1944  ILE VAL TYR ASN LYS PRO LYS HIS ALA GLU LEU ALA ASN          
SEQRES  91 A 1944  GLU TYR ALA GLY PHE LEU MET ALA LEU GLY LEU ASN GLY          
SEQRES  92 A 1944  HIS LEU THR LYS LEU ALA THR LEU ASN ILE HIS ASP TYR          
SEQRES  93 A 1944  LEU THR LYS GLY HIS GLU MET THR SER ILE GLY LEU LEU          
SEQRES  94 A 1944  LEU GLY VAL SER ALA ALA LYS LEU GLY THR MET ASP MET          
SEQRES  95 A 1944  SER ILE THR ARG LEU LEU SER ILE HIS ILE PRO ALA LEU          
SEQRES  96 A 1944  LEU PRO PRO THR SER THR GLU LEU ASP VAL PRO HIS ASN          
SEQRES  97 A 1944  VAL GLN VAL ALA ALA VAL VAL GLY ILE GLY LEU VAL TYR          
SEQRES  98 A 1944  GLN GLY THR ALA HIS ARG HIS THR ALA GLU VAL LEU LEU          
SEQRES  99 A 1944  ALA GLU ILE GLY ARG PRO PRO GLY PRO GLU MET GLU TYR          
SEQRES 100 A 1944  CYS THR ASP ARG GLU SER TYR SER LEU ALA ALA GLY LEU          
SEQRES 101 A 1944  ALA LEU GLY MET VAL CYS LEU GLY HIS GLY SER ASN LEU          
SEQRES 102 A 1944  ILE GLY MET SER ASP LEU ASN VAL PRO GLU GLN LEU TYR          
SEQRES 103 A 1944  GLN TYR MET VAL GLY GLY HIS ARG ARG PHE GLN THR GLY          
SEQRES 104 A 1944  MET HIS ARG GLU LYS HIS LYS SER PRO SER TYR GLN ILE          
SEQRES 105 A 1944  LYS GLU GLY ASP THR ILE ASN VAL ASP VAL THR CYS PRO          
SEQRES 106 A 1944  GLY ALA THR LEU ALA LEU ALA MET ILE TYR LEU LYS THR          
SEQRES 107 A 1944  ASN ASN ARG SER ILE ALA ASP TRP LEU ARG ALA PRO ASP          
SEQRES 108 A 1944  THR MET TYR LEU LEU ASP PHE VAL LYS PRO GLU PHE LEU          
SEQRES 109 A 1944  LEU LEU ARG THR LEU ALA ARG CYS LEU ILE LEU TRP ASP          
SEQRES 110 A 1944  ASP ILE LEU PRO ASN SER LYS TRP VAL ASP SER ASN VAL          
SEQRES 111 A 1944  PRO GLN ILE ILE ARG GLU ASN SER ILE SER LEU SER GLU          
SEQRES 112 A 1944  ILE GLU LEU PRO CYS SER GLU ASP LEU ASN LEU GLU THR          
SEQRES 113 A 1944  LEU SER GLN ALA HIS VAL TYR ILE ILE ALA GLY ALA CYS          
SEQRES 114 A 1944  LEU SER LEU GLY PHE ARG PHE ALA GLY SER GLU ASN LEU          
SEQRES 115 A 1944  SER ALA PHE ASN CYS LEU HIS LYS PHE ALA LYS ASP PHE          
SEQRES 116 A 1944  MET THR TYR LEU SER ALA PRO ASN ALA SER VAL THR GLY          
SEQRES 117 A 1944  PRO HIS ASN LEU GLU THR CYS LEU SER VAL VAL LEU LEU          
SEQRES 118 A 1944  SER LEU ALA MET VAL MET ALA GLY SER GLY ASN LEU LYS          
SEQRES 119 A 1944  VAL LEU GLN LEU CYS ARG PHE LEU HIS MET LYS THR GLY          
SEQRES 120 A 1944  GLY GLU MET ASN TYR GLY PHE HIS LEU ALA HIS HIS MET          
SEQRES 121 A 1944  ALA LEU GLY LEU LEU PHE LEU GLY GLY GLY ARG TYR SER          
SEQRES 122 A 1944  LEU SER THR SER ASN SER SER ILE ALA ALA LEU LEU CYS          
SEQRES 123 A 1944  ALA LEU TYR PRO HIS PHE PRO ALA HIS SER THR ASP ASN          
SEQRES 124 A 1944  ARG TYR HIS LEU GLN ALA LEU ARG HIS LEU TYR VAL LEU          
SEQRES 125 A 1944  ALA ALA GLU PRO ARG LEU LEU VAL PRO VAL ASP VAL ASP          
SEQRES 126 A 1944  THR ASN THR PRO CYS TYR ALA LEU LEU GLU VAL THR TYR          
SEQRES 127 A 1944  LYS GLY THR GLN TRP TYR GLU GLN THR LYS GLU GLU LEU          
SEQRES 128 A 1944  MET ALA PRO THR LEU LEU PRO GLU LEU HIS LEU LEU LYS          
SEQRES 129 A 1944  GLN ILE LYS VAL LYS GLY PRO ARG TYR TRP GLU LEU LEU          
SEQRES 130 A 1944  ILE ASP LEU SER LYS GLY THR GLN HIS LEU LYS SER ILE          
SEQRES 131 A 1944  LEU SER LYS ASP GLY VAL LEU TYR VAL LYS LEU ARG ALA          
SEQRES 132 A 1944  GLY GLN LEU SER TYR LYS GLU ASP PRO MET GLY TRP GLN          
SEQRES 133 A 1944  SER LEU LEU ALA GLN THR VAL ALA ASN ARG ASN SER GLU          
SEQRES 134 A 1944  ALA ARG ALA PHE LYS PRO GLU THR ILE SER ALA PHE THR          
SEQRES 135 A 1944  SER ASP PRO ALA LEU LEU SER PHE ALA GLU TYR PHE CYS          
SEQRES 136 A 1944  LYS PRO THR VAL ASN MET GLY GLN LYS GLN GLU ILE LEU          
SEQRES 137 A 1944  ASP LEU PHE SER SER VAL LEU TYR GLU CYS VAL THR GLN          
SEQRES 138 A 1944  GLU THR PRO GLU MET LEU PRO ALA TYR ILE ALA MET ASP          
SEQRES 139 A 1944  GLN ALA ILE ARG ARG LEU GLY ARG ARG GLU MET SER GLU          
SEQRES 140 A 1944  THR SER GLU LEU TRP GLN ILE LYS LEU VAL LEU GLU PHE          
SEQRES 141 A 1944  PHE SER SER ARG SER HIS GLN GLU ARG LEU GLN ASN HIS          
SEQRES 142 A 1944  PRO LYS ARG GLY LEU PHE MET ASN SER GLU PHE LEU PRO          
SEQRES 143 A 1944  VAL VAL LYS CYS THR ILE ASP ASN THR LEU ASP GLN TRP          
SEQRES 144 A 1944  LEU GLN VAL GLY GLY ASP MET CYS VAL HIS ALA TYR LEU          
SEQRES 145 A 1944  SER GLY GLN PRO LEU GLU GLU SER GLN LEU SER MET LEU          
SEQRES 146 A 1944  ALA CYS PHE LEU VAL TYR HIS SER VAL PRO ALA PRO GLN          
SEQRES 147 A 1944  HIS LEU PRO PRO ILE GLY LEU GLU GLY SER THR SER PHE          
SEQRES 148 A 1944  ALA GLU LEU LEU PHE LYS PHE LYS GLN LEU LYS MET PRO          
SEQRES 149 A 1944  VAL ARG ALA LEU LEU ARG LEU ALA PRO LEU LEU LEU GLY          
SEQRES 150 A 1944  ASN PRO GLN PRO MET VAL MET                                  
SEQRES   1 B   84  MET LYS VAL LYS ILE LYS CYS TRP ASN GLY VAL ALA THR          
SEQRES   2 B   84  TRP LEU TRP VAL ALA ASN ASP GLU ASN CYS GLY ILE CYS          
SEQRES   3 B   84  ARG MET ALA PHE ASN GLY CYS CYS PRO ASP CYS LYS VAL          
SEQRES   4 B   84  PRO GLY ASP ASP CYS PRO LEU VAL TRP GLY GLN CYS SER          
SEQRES   5 B   84  HIS CYS PHE HIS MET HIS CYS ILE LEU LYS TRP LEU HIS          
SEQRES   6 B   84  ALA GLN GLN VAL GLN GLN HIS CYS PRO MET CYS ARG GLN          
SEQRES   7 B   84  GLU TRP LYS PHE LYS GLU                                      
SEQRES   1 C  597  MET ALA ALA SER THR SER MET VAL PRO VAL ALA VAL THR          
SEQRES   2 C  597  ALA ALA VAL ALA PRO VAL LEU SER ILE ASN SER ASP PHE          
SEQRES   3 C  597  SER ASP LEU ARG GLU ILE LYS LYS GLN LEU LEU LEU ILE          
SEQRES   4 C  597  ALA GLY LEU THR ARG GLU ARG GLY LEU LEU HIS SER SER          
SEQRES   5 C  597  LYS TRP SER ALA GLU LEU ALA PHE SER LEU PRO ALA LEU          
SEQRES   6 C  597  PRO LEU ALA GLU LEU GLN PRO PRO PRO PRO ILE THR GLU          
SEQRES   7 C  597  GLU ASP ALA GLN ASP MET ASP ALA TYR THR LEU ALA LYS          
SEQRES   8 C  597  ALA TYR PHE ASP VAL LYS GLU TYR ASP ARG ALA ALA HIS          
SEQRES   9 C  597  PHE LEU HIS GLY CYS ASN SER LYS LYS ALA TYR PHE LEU          
SEQRES  10 C  597  TYR MET TYR SER ARG TYR LEU SER GLY GLU LYS LYS LYS          
SEQRES  11 C  597  ASP ASP GLU THR VAL ASP SER LEU GLY PRO LEU GLU LYS          
SEQRES  12 C  597  GLY GLN VAL LYS ASN GLU ALA LEU ARG GLU LEU ARG VAL          
SEQRES  13 C  597  GLU LEU SER LYS LYS HIS GLN ALA ARG GLU LEU ASP GLY          
SEQRES  14 C  597  PHE GLY LEU TYR LEU TYR GLY VAL VAL LEU ARG LYS LEU          
SEQRES  15 C  597  ASP LEU VAL LYS GLU ALA ILE ASP VAL PHE VAL GLU ALA          
SEQRES  16 C  597  THR HIS VAL LEU PRO LEU HIS TRP GLY ALA TRP LEU GLU          
SEQRES  17 C  597  LEU CYS ASN LEU ILE THR ASP LYS GLU MET LEU LYS PHE          
SEQRES  18 C  597  LEU SER LEU PRO ASP THR TRP MET LYS GLU PHE PHE LEU          
SEQRES  19 C  597  ALA HIS ILE TYR THR GLU LEU GLN LEU ILE GLU GLU ALA          
SEQRES  20 C  597  LEU GLN LYS TYR GLN ASN LEU ILE ASP VAL GLY PHE SER          
SEQRES  21 C  597  LYS SER SER TYR ILE VAL SER GLN ILE ALA VAL ALA TYR          
SEQRES  22 C  597  HIS ASN ILE ARG ASP ILE ASP LYS ALA LEU SER ILE PHE          
SEQRES  23 C  597  ASN GLU LEU ARG LYS GLN ASP PRO TYR ARG ILE GLU ASN          
SEQRES  24 C  597  MET ASP THR PHE SER ASN LEU LEU TYR VAL ARG SER MET          
SEQRES  25 C  597  LYS SER GLU LEU SER TYR LEU ALA HIS ASN LEU CYS GLU          
SEQRES  26 C  597  ILE ASP LYS TYR ARG VAL GLU THR CYS CYS VAL ILE GLY          
SEQRES  27 C  597  ASN TYR TYR SER LEU ARG SER GLN HIS GLU LYS ALA ALA          
SEQRES  28 C  597  LEU TYR PHE GLN ARG ALA LEU LYS LEU ASN PRO ARG TYR          
SEQRES  29 C  597  LEU GLY ALA TRP THR LEU MET GLY HIS GLU TYR MET GLU          
SEQRES  30 C  597  MET LYS ASN THR SER ALA ALA ILE GLN ALA TYR ARG HIS          
SEQRES  31 C  597  ALA ILE GLU VAL ASN LYS ARG ASP TYR ARG ALA TRP TYR          
SEQRES  32 C  597  GLY LEU GLY GLN THR TYR GLU ILE LEU LYS MET PRO PHE          
SEQRES  33 C  597  TYR CYS LEU TYR TYR TYR ARG ARG ALA HIS GLN LEU ARG          
SEQRES  34 C  597  PRO ASN ASP SER ARG MET LEU VAL ALA LEU GLY GLU CYS          
SEQRES  35 C  597  TYR GLU LYS LEU ASN GLN LEU VAL GLU ALA LYS LYS CYS          
SEQRES  36 C  597  TYR TRP ARG ALA TYR ALA VAL GLY ASP VAL GLU LYS MET          
SEQRES  37 C  597  ALA LEU VAL LYS LEU ALA LYS LEU HIS GLU GLN LEU THR          
SEQRES  38 C  597  GLU SER GLU GLN ALA ALA GLN CYS TYR ILE LYS TYR ILE          
SEQRES  39 C  597  GLN ASP ILE TYR SER CYS GLY GLU ILE VAL GLU HIS LEU          
SEQRES  40 C  597  GLU GLU SER THR ALA PHE ARG TYR LEU ALA GLN TYR TYR          
SEQRES  41 C  597  PHE LYS CYS LYS LEU TRP ASP GLU ALA SER THR CYS ALA          
SEQRES  42 C  597  GLN LYS CYS CYS ALA PHE ASN ASP THR ARG GLU GLU GLY          
SEQRES  43 C  597  LYS ALA LEU LEU ARG GLN ILE LEU GLN LEU ARG ASN GLN          
SEQRES  44 C  597  GLY GLU THR PRO THR THR GLU VAL PRO ALA PRO PHE PHE          
SEQRES  45 C  597  LEU PRO ALA SER LEU SER ALA ASN ASN THR PRO THR ARG          
SEQRES  46 C  597  ARG VAL SER PRO LEU ASN LEU SER SER VAL THR PRO              
SEQRES   1 D  121  MET SER THR LEU PHE PRO SER LEU PHE PRO ARG VAL THR          
SEQRES   2 D  121  GLU THR LEU TRP PHE ASN LEU ASP ARG PRO CYS VAL GLU          
SEQRES   3 D  121  GLU THR GLU LEU GLN GLN GLN GLU GLN GLN HIS GLN ALA          
SEQRES   4 D  121  TRP LEU GLN SER ILE ALA GLU LYS ASP ASN ASN LEU VAL          
SEQRES   5 D  121  PRO ILE GLY LYS PRO ALA SER GLU HIS TYR ASP ASP GLU          
SEQRES   6 D  121  GLU GLU GLU ASP ASP GLU ASP ASP GLU ASP SER GLU GLU          
SEQRES   7 D  121  ASP SER GLU ASP ASP GLU ASP MET GLN ASP MET ASP GLU          
SEQRES   8 D  121  MET ASN ASP TYR ASN GLU SER PRO ASP ASP GLY GLU VAL          
SEQRES   9 D  121  ASN GLU VAL ASP MET GLU GLY ASN GLU GLN ASP GLN ASP          
SEQRES  10 D  121  GLN TRP MET ILE                                              
SEQRES   1 E  110  MET ALA ALA SER SER SER SER SER SER ALA GLY GLY VAL          
SEQRES   2 E  110  SER GLY SER SER VAL THR GLY SER GLY PHE SER VAL SER          
SEQRES   3 E  110  ASP LEU ALA PRO PRO ARG LYS ALA LEU PHE THR TYR PRO          
SEQRES   4 E  110  LYS GLY ALA GLY GLU MET LEU GLU ASP GLY SER GLU ARG          
SEQRES   5 E  110  PHE LEU CYS GLU SER VAL PHE SER TYR GLN VAL ALA SER          
SEQRES   6 E  110  THR LEU LYS GLN VAL LYS HIS ASP GLN GLN VAL ALA ARG          
SEQRES   7 E  110  MET GLU LYS LEU ALA GLY LEU VAL GLU GLU LEU GLU ALA          
SEQRES   8 E  110  ASP GLU TRP ARG PHE LYS PRO ILE GLU GLN LEU LEU GLY          
SEQRES   9 E  110  PHE THR PRO SER SER GLY                                      
SEQRES   1 F  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 F  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 F  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 F  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 F  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 F  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 F  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 F  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 F  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 F  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 F  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 F  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 F  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 F  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 F  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 F  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 F  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 F  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 F  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 F  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 F  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 F  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 F  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 F  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 F  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 F  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 F  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 F  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 F  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 F  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 F  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO LYS          
SEQRES  32 F  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 F  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 F  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 F  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 F  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 F  824  MET GLY LYS GLY TYR LEU ALA LEU CYS SER TYR ASN CYS          
SEQRES  38 F  824  LYS GLU ALA ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 F  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 F  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 F  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 F  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 F  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 F  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 F  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 F  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 F  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 F  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 F  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 F  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 F  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 F  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 F  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 F  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 F  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 F  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 F  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 F  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 F  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 F  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 F  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 F  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 F  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 F  824  GLU SER ASP GLU PHE                                          
SEQRES   1 G   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 G   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 G   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 G   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 G   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 G   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 G   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 H  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 H  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 H  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 H  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 H  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 H  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 H  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 H  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 H  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 H  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 H  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 H  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 H  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 H  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 H  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 H  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 H  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 H  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 H  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 H  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 H  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 H  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 H  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 H  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 H  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 H  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 H  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 H  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 H  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 H  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 H  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO LYS          
SEQRES  32 H  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 H  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 H  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 H  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 H  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 H  824  MET GLY LYS GLY TYR LEU ALA LEU CYS SER TYR ASN CYS          
SEQRES  38 H  824  LYS GLU ALA ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 H  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 H  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 H  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 H  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 H  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 H  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 H  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 H  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 H  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 H  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 H  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 H  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 H  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 H  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 H  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 H  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 H  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 H  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 H  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 H  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 H  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 H  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 H  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 H  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 H  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 H  824  GLU SER ASP GLU PHE                                          
SEQRES   1 I  818  MET LEU ARG PHE PRO THR CYS PHE PRO SER PHE ARG VAL          
SEQRES   2 I  818  VAL GLY GLU LYS GLN LEU PRO GLN GLU ILE ILE PHE LEU          
SEQRES   3 I  818  VAL TRP SER PRO LYS ARG ASP LEU ILE ALA LEU ALA ASN          
SEQRES   4 I  818  THR ALA GLY GLU VAL LEU LEU HIS ARG LEU ALA SER PHE          
SEQRES   5 I  818  HIS ARG VAL TRP SER PHE PRO PRO ASN GLU ASN THR GLY          
SEQRES   6 I  818  LYS GLU VAL THR CYS LEU ALA TRP ARG PRO ASP GLY LYS          
SEQRES   7 I  818  LEU LEU ALA PHE ALA LEU ALA ASP THR LYS LYS ILE VAL          
SEQRES   8 I  818  LEU CYS ASP VAL GLU LYS PRO GLU SER LEU HIS SER PHE          
SEQRES   9 I  818  SER VAL GLU ALA PRO VAL SER CYS MET HIS TRP MET GLU          
SEQRES  10 I  818  VAL THR VAL GLU SER SER VAL LEU THR SER PHE TYR ASN          
SEQRES  11 I  818  ALA GLU ASP GLU SER ASN LEU LEU LEU PRO LYS LEU PRO          
SEQRES  12 I  818  THR LEU PRO LYS ASN TYR SER ASN THR SER LYS ILE PHE          
SEQRES  13 I  818  SER GLU GLU ASN SER ASP GLU ILE ILE LYS LEU LEU GLY          
SEQRES  14 I  818  ASP VAL ARG LEU ASN ILE LEU VAL LEU GLY GLY SER SER          
SEQRES  15 I  818  GLY PHE ILE GLU LEU TYR ALA TYR GLY MET PHE LYS ILE          
SEQRES  16 I  818  ALA ARG VAL THR GLY ILE ALA GLY THR CYS LEU ALA LEU          
SEQRES  17 I  818  CYS LEU SER SER ASP LEU LYS SER LEU SER VAL VAL THR          
SEQRES  18 I  818  GLU VAL SER THR ASN GLY ALA SER GLU VAL SER TYR PHE          
SEQRES  19 I  818  GLN LEU GLU THR ASN LEU LEU TYR SER PHE LEU PRO GLU          
SEQRES  20 I  818  VAL THR ARG MET ALA ARG LYS PHE THR HIS ILE SER ALA          
SEQRES  21 I  818  LEU LEU GLN TYR ILE ASN LEU SER LEU THR CYS MET CYS          
SEQRES  22 I  818  GLU ALA TRP GLU GLU ILE LEU MET GLN MET ASP SER ARG          
SEQRES  23 I  818  LEU THR LYS PHE VAL GLN GLU LYS ASN THR THR THR SER          
SEQRES  24 I  818  VAL GLN ASP GLU PHE MET HIS LEU LEU LEU TRP GLY LYS          
SEQRES  25 I  818  ALA SER ALA GLU LEU GLN THR LEU LEU MET ASN GLN LEU          
SEQRES  26 I  818  THR VAL LYS GLY LEU LYS LYS LEU GLY GLN SER ILE GLU          
SEQRES  27 I  818  SER SER TYR SER SER ILE GLN LYS LEU VAL ILE SER HIS          
SEQRES  28 I  818  LEU GLN SER GLY SER GLU SER LEU LEU TYR HIS LEU SER          
SEQRES  29 I  818  GLU LEU LYS GLY MET ALA SER TRP LYS GLN LYS TYR GLU          
SEQRES  30 I  818  PRO LEU GLY LEU ASP ALA ALA GLY ILE GLU GLU ALA ILE          
SEQRES  31 I  818  THR ALA VAL GLY SER PHE ILE LEU LYS ALA ASN GLU LEU          
SEQRES  32 I  818  LEU GLN VAL ILE ASP SER SER MET LYS ASN PHE LYS ALA          
SEQRES  33 I  818  PHE PHE ARG TRP LEU TYR VAL ALA MET LEU ARG MET THR          
SEQRES  34 I  818  GLU ASP HIS VAL LEU PRO GLU LEU ASN LYS MET THR GLN          
SEQRES  35 I  818  LYS ASP ILE THR PHE VAL ALA GLU PHE LEU THR GLU HIS          
SEQRES  36 I  818  PHE ASN GLU ALA PRO ASP LEU TYR ASN ARG LYS GLY LYS          
SEQRES  37 I  818  TYR PHE ASN VAL GLU ARG VAL GLY GLN TYR LEU LYS ASP          
SEQRES  38 I  818  GLU ASP ASP ASP LEU VAL SER PRO PRO ASN THR GLU GLY          
SEQRES  39 I  818  ASN GLN TRP TYR ASP PHE LEU GLN ASN SER SER HIS LEU          
SEQRES  40 I  818  LYS GLU SER PRO LEU LEU PHE PRO TYR TYR PRO ARG LYS          
SEQRES  41 I  818  SER LEU HIS PHE VAL LYS ARG ARG MET GLU ASN ILE ILE          
SEQRES  42 I  818  ASP GLN CYS LEU GLN LYS PRO ALA ASP VAL ILE GLY LYS          
SEQRES  43 I  818  SER MET ASN GLN ALA ILE CYS ILE PRO LEU TYR ARG ASP          
SEQRES  44 I  818  THR ARG SER GLU ASP SER THR ARG ARG LEU PHE LYS PHE          
SEQRES  45 I  818  PRO PHE LEU TRP ASN ASN LYS THR SER ASN LEU HIS TYR          
SEQRES  46 I  818  LEU LEU PHE THR ILE LEU GLU ASP SER LEU TYR LYS MET          
SEQRES  47 I  818  CYS ILE LEU ARG ARG HIS THR ASP ILE SER GLN SER VAL          
SEQRES  48 I  818  SER ASN GLY LEU ILE ALA ILE LYS PHE GLY SER PHE THR          
SEQRES  49 I  818  TYR ALA THR THR GLU LYS VAL ARG ARG SER ILE TYR SER          
SEQRES  50 I  818  CYS LEU ASP ALA GLN PHE TYR ASP ASP GLU THR VAL THR          
SEQRES  51 I  818  VAL VAL LEU LYS ASP THR VAL GLY ARG GLU GLY ARG ASP          
SEQRES  52 I  818  ARG LEU LEU VAL GLN LEU PRO LEU SER LEU VAL TYR ASN          
SEQRES  53 I  818  SER GLU ASP SER ALA GLU TYR GLN PHE THR GLY THR TYR          
SEQRES  54 I  818  SER THR ARG LEU ASP GLU GLN CYS SER ALA ILE PRO THR          
SEQRES  55 I  818  ARG THR MET HIS PHE GLU LYS HIS TRP ARG LEU LEU GLU          
SEQRES  56 I  818  SER MET LYS ALA GLN TYR VAL ALA GLY ASN GLY PHE ARG          
SEQRES  57 I  818  LYS VAL SER CYS VAL LEU SER SER ASN LEU ARG HIS VAL          
SEQRES  58 I  818  ARG VAL PHE GLU MET ASP ILE ASP ASP GLU TRP GLU LEU          
SEQRES  59 I  818  ASP GLU SER SER ASP GLU GLU GLU GLU ALA SER ASN LYS          
SEQRES  60 I  818  PRO VAL LYS ILE LYS GLU GLU VAL LEU SER GLU SER GLU          
SEQRES  61 I  818  ALA GLU ASN GLN GLN ALA GLY ALA ALA ALA LEU ALA PRO          
SEQRES  62 I  818  GLU ILE VAL ILE LYS VAL GLU LYS LEU ASP PRO GLU LEU          
SEQRES  63 I  818  ASP SER GLY GLY SER LEU GLU VAL LEU PHE GLN GLY              
SEQRES   1 J  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 J  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 J  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 J  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 J  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 J  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 J  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 J  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 J  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 J  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 J  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 J  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 J  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 J  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 J  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 J  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 J  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 J  620  GLU SER VAL ASP GLY LEU GLN GLU ASN LEU ASP VAL VAL          
SEQRES  19 J  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 J  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 J  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 J  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 J  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 J  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 J  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 J  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 J  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 J  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 J  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 J  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 J  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 J  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 J  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 J  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 J  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 J  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 J  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 J  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 J  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 J  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 J  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 J  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 J  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 J  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 J  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 J  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 J  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 J  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 K  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 K  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 K  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 K  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 K  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 K  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 K  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 K  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 K  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 K  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 K  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 K  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 K  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 K  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 K  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 K  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 K  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 K  620  GLU SER VAL ASP GLY LEU GLN GLU ASN LEU ASP VAL VAL          
SEQRES  19 K  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 K  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 K  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 K  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 K  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 K  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 K  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 K  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 K  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 K  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 K  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 K  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 K  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 K  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 K  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 K  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 K  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 K  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 K  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 K  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 K  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 K  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 K  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 K  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 K  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 K  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 K  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 K  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 K  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 K  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 L  185  MET THR THR PRO ASN LYS THR PRO PRO GLY ALA ASP PRO          
SEQRES   2 L  185  LYS GLN LEU GLU ARG THR GLY THR VAL ARG GLU ILE GLY          
SEQRES   3 L  185  SER GLN ALA VAL TRP SER LEU SER SER CYS LYS PRO GLY          
SEQRES   4 L  185  PHE GLY VAL ASP GLN LEU ARG ASP ASP ASN LEU GLU THR          
SEQRES   5 L  185  TYR TRP GLN SER ASP GLY SER GLN PRO HIS LEU VAL ASN          
SEQRES   6 L  185  ILE GLN PHE ARG ARG LYS THR THR VAL LYS THR LEU CYS          
SEQRES   7 L  185  ILE TYR ALA ASP TYR LYS SER ASP GLU SER TYR THR PRO          
SEQRES   8 L  185  SER LYS ILE SER VAL ARG VAL GLY ASN ASN PHE HIS ASN          
SEQRES   9 L  185  LEU GLN GLU ILE ARG GLN LEU GLU LEU VAL GLU PRO SER          
SEQRES  10 L  185  GLY TRP ILE HIS VAL PRO LEU THR ASP ASN HIS LYS LYS          
SEQRES  11 L  185  PRO THR ARG THR PHE MET ILE GLN ILE ALA VAL LEU ALA          
SEQRES  12 L  185  ASN HIS GLN ASN GLY ARG ASP THR HIS MET ARG GLN ILE          
SEQRES  13 L  185  LYS ILE TYR THR PRO VAL GLU GLU SER SER ILE GLY LYS          
SEQRES  14 L  185  PHE PRO ARG CYS THR THR ILE ASP PHE MET MET TYR ARG          
SEQRES  15 L  185  SER ILE ARG                                                  
SEQRES   1 M   74  MET ASP SER GLU VAL GLN ARG ASP GLY ARG ILE LEU ASP          
SEQRES   2 M   74  LEU ILE ASP ASP ALA TRP ARG GLU ASP LYS LEU PRO TYR          
SEQRES   3 M   74  GLU ASP VAL ALA ILE PRO LEU ASN GLU LEU PRO GLU PRO          
SEQRES   4 M   74  GLU GLN ASP ASN GLY GLY THR THR GLU SER VAL LYS GLU          
SEQRES   5 M   74  GLN GLU MET LYS TRP THR ASP LEU ALA LEU GLN TYR LEU          
SEQRES   6 M   74  HIS GLU ASN VAL PRO PRO ILE GLY ASN                          
SEQRES   1 N  822  MET ALA ALA ALA VAL VAL VAL ALA GLU GLY ASP SER ASP          
SEQRES   2 N  822  SER ARG PRO GLY GLN GLU LEU LEU VAL ALA TRP ASN THR          
SEQRES   3 N  822  VAL SER THR GLY LEU VAL PRO PRO ALA ALA LEU GLY LEU          
SEQRES   4 N  822  VAL SER SER ARG THR SER GLY ALA VAL PRO PRO LYS GLU          
SEQRES   5 N  822  GLU GLU LEU ARG ALA ALA VAL GLU VAL LEU ARG GLY HIS          
SEQRES   6 N  822  GLY LEU HIS SER VAL LEU GLU GLU TRP PHE VAL GLU VAL          
SEQRES   7 N  822  LEU GLN ASN ASP LEU GLN ALA ASN ILE SER PRO GLU PHE          
SEQRES   8 N  822  TRP ASN ALA ILE SER GLN CYS GLU ASN SER ALA ASP GLU          
SEQRES   9 N  822  PRO GLN CYS LEU LEU LEU LEU LEU ASP ALA PHE GLY LEU          
SEQRES  10 N  822  LEU GLU SER ARG LEU ASP PRO TYR LEU ARG SER LEU GLU          
SEQRES  11 N  822  LEU LEU GLU LYS TRP THR ARG LEU GLY LEU LEU MET GLY          
SEQRES  12 N  822  THR GLY ALA GLN GLY LEU ARG GLU GLU VAL HIS THR MET          
SEQRES  13 N  822  LEU ARG GLY VAL LEU PHE PHE SER THR PRO ARG THR PHE          
SEQRES  14 N  822  GLN GLU MET ILE GLN ARG LEU TYR GLY CYS PHE LEU ARG          
SEQRES  15 N  822  VAL TYR MET GLN SER LYS ARG LYS GLY GLU GLY GLY THR          
SEQRES  16 N  822  ASP PRO GLU LEU GLU GLY GLU LEU ASP SER ARG TYR ALA          
SEQRES  17 N  822  ARG ARG ARG TYR TYR ARG LEU LEU GLN SER PRO LEU CYS          
SEQRES  18 N  822  ALA GLY CYS SER SER ASP LYS GLN GLN CYS TRP CYS ARG          
SEQRES  19 N  822  GLN ALA LEU GLU GLN PHE HIS GLN LEU SER GLN VAL LEU          
SEQRES  20 N  822  HIS ARG LEU SER LEU LEU GLU ARG VAL SER ALA GLU ALA          
SEQRES  21 N  822  VAL THR THR THR LEU HIS GLN VAL THR ARG GLU ARG MET          
SEQRES  22 N  822  GLU ASP ARG CYS ARG GLY GLU TYR GLU ARG SER PHE LEU          
SEQRES  23 N  822  ARG GLU PHE HIS LYS TRP ILE GLU ARG VAL VAL GLY TRP          
SEQRES  24 N  822  LEU GLY LYS VAL PHE LEU GLN ASP GLY PRO ALA ARG PRO          
SEQRES  25 N  822  ALA SER PRO GLU ALA GLY ASN THR LEU ARG ARG TRP ARG          
SEQRES  26 N  822  CYS HIS VAL GLN ARG PHE PHE TYR ARG ILE TYR ALA SER          
SEQRES  27 N  822  LEU ARG ILE GLU GLU LEU PHE SER ILE VAL ARG ASP PHE          
SEQRES  28 N  822  PRO ASP SER ARG PRO ALA ILE GLU ASP LEU LYS TYR CYS          
SEQRES  29 N  822  LEU GLU ARG THR ASP GLN ARG GLN GLN LEU LEU VAL SER          
SEQRES  30 N  822  LEU LYS ALA ALA LEU GLU THR ARG LEU LEU HIS PRO GLY          
SEQRES  31 N  822  VAL ASN THR CYS ASP ILE ILE THR LEU TYR ILE SER ALA          
SEQRES  32 N  822  ILE LYS ALA LEU ARG VAL LEU ASP PRO SER MET VAL ILE          
SEQRES  33 N  822  LEU GLU VAL ALA CYS GLU PRO ILE ARG ARG TYR LEU ARG          
SEQRES  34 N  822  THR ARG GLU ASP THR VAL ARG GLN ILE VAL ALA GLY LEU          
SEQRES  35 N  822  THR GLY ASP SER ASP GLY THR GLY ASP LEU ALA VAL GLU          
SEQRES  36 N  822  LEU SER LYS THR ASP PRO ALA SER LEU GLU THR GLY GLN          
SEQRES  37 N  822  ASP SER GLU ASP ASP SER GLY GLU PRO GLU ASP TRP VAL          
SEQRES  38 N  822  PRO ASP PRO VAL ASP ALA ASP PRO GLY LYS SER SER SER          
SEQRES  39 N  822  LYS ARG ARG SER SER ASP ILE ILE SER LEU LEU VAL SER          
SEQRES  40 N  822  ILE TYR GLY SER LYS ASP LEU PHE ILE ASN GLU TYR ARG          
SEQRES  41 N  822  SER LEU LEU ALA ASP ARG LEU LEU HIS GLN PHE SER PHE          
SEQRES  42 N  822  SER PRO GLU ARG GLU ILE ARG ASN VAL GLU LEU LEU LYS          
SEQRES  43 N  822  LEU ARG PHE GLY GLU ALA PRO MET HIS PHE CYS GLU VAL          
SEQRES  44 N  822  MET LEU LYS ASP MET ALA ASP SER ARG ARG ILE ASN ALA          
SEQRES  45 N  822  ASN ILE ARG GLU GLU ASP GLU LYS ARG PRO ALA GLU GLU          
SEQRES  46 N  822  GLN PRO PRO PHE GLY VAL TYR ALA VAL ILE LEU SER SER          
SEQRES  47 N  822  GLU PHE TRP PRO PRO PHE LYS ASP GLU LYS LEU GLU VAL          
SEQRES  48 N  822  PRO GLU ASP ILE ARG ALA ALA LEU GLU ALA TYR CYS LYS          
SEQRES  49 N  822  LYS TYR GLU GLN LEU LYS ALA MET ARG THR LEU SER TRP          
SEQRES  50 N  822  LYS HIS THR LEU GLY LEU VAL THR MET ASP VAL GLU LEU          
SEQRES  51 N  822  ALA ASP ARG THR LEU SER VAL ALA VAL THR PRO VAL GLN          
SEQRES  52 N  822  ALA VAL ILE LEU LEU TYR PHE GLN ASP GLN ALA SER TRP          
SEQRES  53 N  822  THR LEU GLU GLU LEU SER LYS ALA VAL LYS MET PRO VAL          
SEQRES  54 N  822  ALA LEU LEU ARG ARG ARG MET SER VAL TRP LEU GLN GLN          
SEQRES  55 N  822  GLY VAL LEU ARG GLU GLU PRO PRO GLY THR PHE SER VAL          
SEQRES  56 N  822  ILE GLU GLU GLU ARG PRO GLN ASP ARG ASP ASN MET VAL          
SEQRES  57 N  822  LEU ILE ASP SER ASP ASP GLU SER ASP SER GLY MET ALA          
SEQRES  58 N  822  SER GLN ALA ASP GLN LYS GLU GLU GLU LEU LEU LEU PHE          
SEQRES  59 N  822  TRP THR TYR ILE GLN ALA MET LEU THR ASN LEU GLU SER          
SEQRES  60 N  822  LEU SER LEU ASP ARG ILE TYR ASN MET LEU ARG MET PHE          
SEQRES  61 N  822  VAL VAL THR GLY PRO ALA LEU ALA GLU ILE ASP LEU GLN          
SEQRES  62 N  822  GLU LEU GLN GLY TYR LEU GLN LYS LYS VAL ARG ASP GLN          
SEQRES  63 N  822  GLN LEU VAL TYR SER ALA GLY VAL TYR ARG LEU PRO LYS          
SEQRES  64 N  822  ASN CYS SER                                                  
SEQRES   1 O  755  MET ALA SER VAL HIS GLU SER LEU TYR PHE ASN PRO MET          
SEQRES   2 O  755  MET THR ASN GLY VAL VAL HIS ALA ASN VAL PHE GLY ILE          
SEQRES   3 O  755  LYS ASP TRP VAL THR PRO TYR LYS ILE ALA VAL LEU VAL          
SEQRES   4 O  755  LEU LEU ASN GLU MET SER ARG THR GLY GLU GLY ALA VAL          
SEQRES   5 O  755  SER LEU MET GLU ARG ARG ARG LEU ASN GLN LEU LEU LEU          
SEQRES   6 O  755  PRO LEU LEU GLN GLY PRO ASP ILE THR LEU SER LYS LEU          
SEQRES   7 O  755  TYR LYS LEU ILE GLU GLU SER CYS PRO GLN LEU ALA ASN          
SEQRES   8 O  755  SER VAL GLN ILE ARG ILE LYS LEU MET ALA GLU GLY GLU          
SEQRES   9 O  755  LEU LYS ASP MET GLU GLN PHE PHE ASP ASP LEU SER ASP          
SEQRES  10 O  755  SER PHE SER GLY THR GLU PRO GLU VAL HIS LYS THR SER          
SEQRES  11 O  755  VAL VAL GLY LEU PHE LEU ARG HIS MET ILE LEU ALA TYR          
SEQRES  12 O  755  SER LYS LEU SER PHE SER GLN VAL PHE LYS LEU TYR THR          
SEQRES  13 O  755  ALA LEU GLN GLN TYR PHE GLN ASN GLY GLU LYS LYS THR          
SEQRES  14 O  755  VAL GLU ASP ALA ASP MET GLU LEU THR SER ARG ASP GLU          
SEQRES  15 O  755  GLY GLU ARG LYS MET GLU LYS GLU GLU LEU ASP VAL SER          
SEQRES  16 O  755  VAL ARG GLU GLU GLU VAL SER CYS SER GLY PRO LEU SER          
SEQRES  17 O  755  GLN LYS GLN ALA GLU PHE PHE LEU SER GLN GLN ALA SER          
SEQRES  18 O  755  LEU LEU LYS ASN ASP GLU THR LYS ALA LEU THR PRO ALA          
SEQRES  19 O  755  SER LEU GLN LYS GLU LEU ASN ASN LEU LEU LYS PHE ASN          
SEQRES  20 O  755  PRO ASP PHE ALA GLU ALA HIS TYR LEU SER TYR LEU ASN          
SEQRES  21 O  755  ASN LEU ARG VAL GLN ASP VAL PHE SER SER THR HIS SER          
SEQRES  22 O  755  LEU LEU HIS TYR PHE ASP ARG LEU ILE LEU THR GLY ALA          
SEQRES  23 O  755  GLU SER LYS SER ASN GLY GLU GLU GLY TYR GLY ARG SER          
SEQRES  24 O  755  LEU ARG TYR ALA ALA LEU ASN LEU ALA ALA LEU HIS CYS          
SEQRES  25 O  755  ARG PHE GLY HIS TYR GLN GLN ALA GLU LEU ALA LEU GLN          
SEQRES  26 O  755  GLU ALA ILE ARG ILE ALA GLN GLU SER ASN ASP HIS VAL          
SEQRES  27 O  755  CYS LEU GLN HIS CYS LEU SER TRP LEU TYR VAL LEU GLY          
SEQRES  28 O  755  GLN LYS ARG SER ASP SER TYR VAL LEU LEU GLU HIS SER          
SEQRES  29 O  755  VAL LYS LYS ALA VAL HIS PHE GLY LEU PRO TYR LEU ALA          
SEQRES  30 O  755  SER LEU GLY ILE GLN SER LEU VAL GLN GLN ARG ALA PHE          
SEQRES  31 O  755  ALA GLY LYS THR ALA ASN LYS LEU MET ASP ALA LEU LYS          
SEQRES  32 O  755  ASP SER ASP LEU LEU HIS TRP LYS HIS SER LEU SER GLU          
SEQRES  33 O  755  LEU ILE ASP ILE SER ILE ALA GLN LYS THR ALA ILE TRP          
SEQRES  34 O  755  ARG LEU TYR GLY ARG SER THR MET ALA LEU GLN GLN ALA          
SEQRES  35 O  755  GLN MET LEU LEU SER MET ASN SER LEU GLU ALA VAL ASN          
SEQRES  36 O  755  ALA GLY VAL GLN GLN ASN ASN THR GLU SER PHE ALA VAL          
SEQRES  37 O  755  ALA LEU CYS HIS LEU ALA GLU LEU HIS ALA GLU GLN GLY          
SEQRES  38 O  755  CYS PHE ALA ALA ALA SER GLU VAL LEU LYS HIS LEU LYS          
SEQRES  39 O  755  GLU ARG PHE PRO PRO ASN SER GLN HIS ALA GLN LEU TRP          
SEQRES  40 O  755  MET LEU CYS ASP GLN LYS ILE GLN PHE ASP ARG ALA MET          
SEQRES  41 O  755  ASN ASP GLY LYS TYR HIS LEU ALA ASP SER LEU VAL THR          
SEQRES  42 O  755  GLY ILE THR ALA LEU ASN SER ILE GLU GLY VAL TYR ARG          
SEQRES  43 O  755  LYS ALA VAL VAL LEU GLN ALA GLN ASN GLN MET SER GLU          
SEQRES  44 O  755  ALA HIS LYS LEU LEU GLN LYS LEU LEU VAL HIS CYS GLN          
SEQRES  45 O  755  LYS LEU LYS ASN THR GLU MET VAL ILE SER VAL LEU LEU          
SEQRES  46 O  755  SER VAL ALA GLU LEU TYR TRP ARG SER SER SER PRO THR          
SEQRES  47 O  755  ILE ALA LEU PRO MET LEU LEU GLN ALA LEU ALA LEU SER          
SEQRES  48 O  755  LYS GLU TYR ARG LEU GLN TYR LEU ALA SER GLU THR VAL          
SEQRES  49 O  755  LEU ASN LEU ALA PHE ALA GLN LEU ILE LEU GLY ILE PRO          
SEQRES  50 O  755  GLU GLN ALA LEU SER LEU LEU HIS MET ALA ILE GLU PRO          
SEQRES  51 O  755  ILE LEU ALA ASP GLY ALA ILE LEU ASP LYS GLY ARG ALA          
SEQRES  52 O  755  MET PHE LEU VAL ALA LYS CYS GLN VAL ALA SER ALA ALA          
SEQRES  53 O  755  SER TYR ASP GLN PRO LYS LYS ALA GLU ALA LEU GLU ALA          
SEQRES  54 O  755  ALA ILE GLU ASN LEU ASN GLU ALA LYS ASN TYR PHE ALA          
SEQRES  55 O  755  LYS VAL ASP CYS LYS GLU ARG ILE ARG ASP VAL VAL TYR          
SEQRES  56 O  755  PHE GLN ALA ARG LEU TYR HIS THR LEU GLY LYS THR GLN          
SEQRES  57 O  755  GLU ARG ASN ARG CYS ALA MET LEU PHE ARG GLN LEU HIS          
SEQRES  58 O  755  GLN GLU LEU PRO SER HIS GLY VAL PRO LEU ILE ASN HIS          
SEQRES  59 O  755  LEU                                                          
SEQRES   1 P  597  MET ALA ALA SER THR SER MET VAL PRO VAL ALA VAL THR          
SEQRES   2 P  597  ALA ALA VAL ALA PRO VAL LEU SER ILE ASN SER ASP PHE          
SEQRES   3 P  597  SER ASP LEU ARG GLU ILE LYS LYS GLN LEU LEU LEU ILE          
SEQRES   4 P  597  ALA GLY LEU THR ARG GLU ARG GLY LEU LEU HIS SER SER          
SEQRES   5 P  597  LYS TRP SER ALA GLU LEU ALA PHE SER LEU PRO ALA LEU          
SEQRES   6 P  597  PRO LEU ALA GLU LEU GLN PRO PRO PRO PRO ILE THR GLU          
SEQRES   7 P  597  GLU ASP ALA GLN ASP MET ASP ALA TYR THR LEU ALA LYS          
SEQRES   8 P  597  ALA TYR PHE ASP VAL LYS GLU TYR ASP ARG ALA ALA HIS          
SEQRES   9 P  597  PHE LEU HIS GLY CYS ASN SER LYS LYS ALA TYR PHE LEU          
SEQRES  10 P  597  TYR MET TYR SER ARG TYR LEU SER GLY GLU LYS LYS LYS          
SEQRES  11 P  597  ASP ASP GLU THR VAL ASP SER LEU GLY PRO LEU GLU LYS          
SEQRES  12 P  597  GLY GLN VAL LYS ASN GLU ALA LEU ARG GLU LEU ARG VAL          
SEQRES  13 P  597  GLU LEU SER LYS LYS HIS GLN ALA ARG GLU LEU ASP GLY          
SEQRES  14 P  597  PHE GLY LEU TYR LEU TYR GLY VAL VAL LEU ARG LYS LEU          
SEQRES  15 P  597  ASP LEU VAL LYS GLU ALA ILE ASP VAL PHE VAL GLU ALA          
SEQRES  16 P  597  THR HIS VAL LEU PRO LEU HIS TRP GLY ALA TRP LEU GLU          
SEQRES  17 P  597  LEU CYS ASN LEU ILE THR ASP LYS GLU MET LEU LYS PHE          
SEQRES  18 P  597  LEU SER LEU PRO ASP THR TRP MET LYS GLU PHE PHE LEU          
SEQRES  19 P  597  ALA HIS ILE TYR THR GLU LEU GLN LEU ILE GLU GLU ALA          
SEQRES  20 P  597  LEU GLN LYS TYR GLN ASN LEU ILE ASP VAL GLY PHE SER          
SEQRES  21 P  597  LYS SER SER TYR ILE VAL SER GLN ILE ALA VAL ALA TYR          
SEQRES  22 P  597  HIS ASN ILE ARG ASP ILE ASP LYS ALA LEU SER ILE PHE          
SEQRES  23 P  597  ASN GLU LEU ARG LYS GLN ASP PRO TYR ARG ILE GLU ASN          
SEQRES  24 P  597  MET ASP THR PHE SER ASN LEU LEU TYR VAL ARG SER MET          
SEQRES  25 P  597  LYS SER GLU LEU SER TYR LEU ALA HIS ASN LEU CYS GLU          
SEQRES  26 P  597  ILE ASP LYS TYR ARG VAL GLU THR CYS CYS VAL ILE GLY          
SEQRES  27 P  597  ASN TYR TYR SER LEU ARG SER GLN HIS GLU LYS ALA ALA          
SEQRES  28 P  597  LEU TYR PHE GLN ARG ALA LEU LYS LEU ASN PRO ARG TYR          
SEQRES  29 P  597  LEU GLY ALA TRP THR LEU MET GLY HIS GLU TYR MET GLU          
SEQRES  30 P  597  MET LYS ASN THR SER ALA ALA ILE GLN ALA TYR ARG HIS          
SEQRES  31 P  597  ALA ILE GLU VAL ASN LYS ARG ASP TYR ARG ALA TRP TYR          
SEQRES  32 P  597  GLY LEU GLY GLN THR TYR GLU ILE LEU LYS MET PRO PHE          
SEQRES  33 P  597  TYR CYS LEU TYR TYR TYR ARG ARG ALA HIS GLN LEU ARG          
SEQRES  34 P  597  PRO ASN ASP SER ARG MET LEU VAL ALA LEU GLY GLU CYS          
SEQRES  35 P  597  TYR GLU LYS LEU ASN GLN LEU VAL GLU ALA LYS LYS CYS          
SEQRES  36 P  597  TYR TRP ARG ALA TYR ALA VAL GLY ASP VAL GLU LYS MET          
SEQRES  37 P  597  ALA LEU VAL LYS LEU ALA LYS LEU HIS GLU GLN LEU THR          
SEQRES  38 P  597  GLU SER GLU GLN ALA ALA GLN CYS TYR ILE LYS TYR ILE          
SEQRES  39 P  597  GLN ASP ILE TYR SER CYS GLY GLU ILE VAL GLU HIS LEU          
SEQRES  40 P  597  GLU GLU SER THR ALA PHE ARG TYR LEU ALA GLN TYR TYR          
SEQRES  41 P  597  PHE LYS CYS LYS LEU TRP ASP GLU ALA SER THR CYS ALA          
SEQRES  42 P  597  GLN LYS CYS CYS ALA PHE ASN ASP THR ARG GLU GLU GLY          
SEQRES  43 P  597  LYS ALA LEU LEU ARG GLN ILE LEU GLN LEU ARG ASN GLN          
SEQRES  44 P  597  GLY GLU THR PRO THR THR GLU VAL PRO ALA PRO PHE PHE          
SEQRES  45 P  597  LEU PRO ALA SER LEU SER ALA ASN ASN THR PRO THR ARG          
SEQRES  46 P  597  ARG VAL SER PRO LEU ASN LEU SER SER VAL THR PRO              
SEQRES   1 R  493  MET ASP GLN ASP TYR GLU ARG ARG LEU LEU ARG GLN ILE          
SEQRES   2 R  493  VAL ILE GLN ASN GLU ASN THR MET PRO ARG VAL THR GLU          
SEQRES   3 R  493  MET ARG ARG THR LEU THR PRO ALA SER SER PRO VAL SER          
SEQRES   4 R  493  SER PRO SER LYS HIS GLY ASP ARG PHE ILE PRO SER ARG          
SEQRES   5 R  493  ALA GLY ALA ASN TRP SER VAL ASN PHE HIS ARG ILE ASN          
SEQRES   6 R  493  GLU ASN GLU LYS SER PRO SER GLN ASN ARG LYS ALA LYS          
SEQRES   7 R  493  ASP ALA THR SER ASP ASN GLY LYS ASP GLY LEU ALA TYR          
SEQRES   8 R  493  SER ALA LEU LEU LYS ASN GLU LEU LEU GLY ALA GLY ILE          
SEQRES   9 R  493  GLU LYS VAL GLN ASP PRO GLN THR GLU ASP ARG ARG LEU          
SEQRES  10 R  493  GLN PRO SER THR PRO GLU LYS LYS GLY LEU PHE THR TYR          
SEQRES  11 R  493  SER LEU SER THR LYS ARG SER SER PRO ASP ASP GLY ASN          
SEQRES  12 R  493  ASP VAL SER PRO TYR SER LEU SER PRO VAL SER ASN LYS          
SEQRES  13 R  493  SER GLN LYS LEU LEU ARG SER PRO ARG LYS PRO THR ARG          
SEQRES  14 R  493  LYS ILE SER LYS ILE PRO PHE LYS VAL LEU ASP ALA PRO          
SEQRES  15 R  493  GLU LEU GLN ASP ASP PHE TYR LEU ASN LEU VAL ASP TRP          
SEQRES  16 R  493  SER SER LEU ASN VAL LEU SER VAL GLY LEU GLY THR CYS          
SEQRES  17 R  493  VAL TYR LEU TRP SER ALA CYS THR SER GLN VAL THR ARG          
SEQRES  18 R  493  LEU CYS ASP LEU SER VAL GLU GLY ASP SER VAL THR SER          
SEQRES  19 R  493  VAL GLY TRP SER GLU ARG GLY ASN LEU VAL ALA VAL GLY          
SEQRES  20 R  493  THR HIS LYS GLY PHE VAL GLN ILE TRP ASP ALA ALA ALA          
SEQRES  21 R  493  GLY LYS LYS LEU SER MET LEU GLU GLY HIS THR ALA ARG          
SEQRES  22 R  493  VAL GLY ALA LEU ALA TRP ASN ALA GLU GLN LEU SER SER          
SEQRES  23 R  493  GLY SER ARG ASP ARG MET ILE LEU GLN ARG ASP ILE ARG          
SEQRES  24 R  493  THR PRO PRO LEU GLN SER GLU ARG ARG LEU GLN GLY HIS          
SEQRES  25 R  493  ARG GLN GLU VAL CYS GLY LEU LYS TRP SER THR ASP HIS          
SEQRES  26 R  493  GLN LEU LEU ALA SER GLY GLY ASN ASP ASN LYS LEU LEU          
SEQRES  27 R  493  VAL TRP ASN HIS SER SER LEU SER PRO VAL GLN GLN TYR          
SEQRES  28 R  493  THR GLU HIS LEU ALA ALA VAL LYS ALA ILE ALA TRP SER          
SEQRES  29 R  493  PRO HIS GLN HIS GLY LEU LEU ALA SER GLY GLY GLY THR          
SEQRES  30 R  493  ALA ASP ARG CYS ILE ARG PHE TRP ASN THR LEU THR GLY          
SEQRES  31 R  493  GLN PRO LEU GLN CYS ILE ASP THR GLY SER GLN VAL CYS          
SEQRES  32 R  493  ASN LEU ALA TRP SER LYS HIS ALA ASN GLU LEU VAL SER          
SEQRES  33 R  493  THR HIS GLY TYR SER GLN ASN GLN ILE LEU VAL TRP LYS          
SEQRES  34 R  493  TYR PRO SER LEU THR GLN VAL ALA LYS LEU THR GLY HIS          
SEQRES  35 R  493  SER TYR ARG VAL LEU TYR LEU ALA MET SER PRO ASP GLY          
SEQRES  36 R  493  GLU ALA ILE VAL THR GLY ALA GLY ASP GLU THR LEU ARG          
SEQRES  37 R  493  PHE TRP ASN VAL PHE SER LYS THR ARG SER THR LYS GLU          
SEQRES  38 R  493  SER VAL SER VAL LEU ASN LEU PHE THR ARG ILE ARG              
SEQRES   1 S  157  GLY SER ARG GLU ASN GLU LEU SER ALA GLY LEU SER LYS          
SEQRES   2 S  157  ARG LYS HIS ARG GLY SER GLY SER GLY SER GLY SER ILE          
SEQRES   3 S  157  SER GLY VAL SER THR ASN LYS GLU ASN GLU GLY PRO GLU          
SEQRES   4 S  157  TYR PRO THR LYS ILE GLU CYS TYR LEU GLU GLU GLN LYS          
SEQRES   5 S  157  PRO LYS ARG ALA ALA LEU SER ASP ILE THR ASN SER PHE          
SEQRES   6 S  157  ASN LYS MET ASN SER GLY SER SER GLY SER GLY SER SER          
SEQRES   7 S  157  GLY MET GLN ILE LEU VAL LYS THR PRO ARG GLY LYS THR          
SEQRES   8 S  157  ILE THR LEU GLU VAL GLU PRO SER ASP THR ILE GLU ASN          
SEQRES   9 S  157  VAL LYS ALA LYS ILE GLN ASP LYS GLU GLY ILE PRO PRO          
SEQRES  10 S  157  ASP GLN GLN ILE LEU PHE PHE ALA VAL LYS ARG LEU GLU          
SEQRES  11 S  157  ASP GLY ARG THR LEU SER ASP TYR ASN ILE GLN LYS LYS          
SEQRES  12 S  157  SER SER LEU LEU LEU ALA MET ARG VAL PRO GLY LYS MET          
SEQRES  13 S  157  LYS                                                          
SEQRES   1 U  188  SEC ASX MET ALA SER GLN ASN ARG ASP PRO ALA ALA THR          
SEQRES   2 U  188  SER VAL ALA ALA ALA ARG LYS GLY ALA GLU PRO SER GLY          
SEQRES   3 U  188  GLY ALA ALA ARG GLY PRO VAL GLY LYS ARG LEU GLN GLN          
SEQRES   4 U  188  GLU LEU MET THR LEU MET MET SER GLY ASP LYS GLY ILE          
SEQRES   5 U  188  SER ALA PHE PRO GLU SER ASP ASN LEU PHE LYS TRP VAL          
SEQRES   6 U  188  GLY THR ILE HIS GLY ALA ALA GLY THR VAL TYR GLU ASP          
SEQRES   7 U  188  LEU ARG TYR LYS LEU SER LEU GLU PHE PRO SER GLY TYR          
SEQRES   8 U  188  PRO TYR ASN ALA PRO THR VAL LYS PHE LEU THR PRO ALA          
SEQRES   9 U  188  TYR HIS PRO ASN VAL ASP THR GLN GLY ASN ILE CYS LEU          
SEQRES  10 U  188  ASP ILE LEU LYS GLU LYS TRP SER ALA LEU TYR ASP VAL          
SEQRES  11 U  188  ARG THR ILE LEU LEU SER ILE GLN SER LEU LEU GLY GLU          
SEQRES  12 U  188  PRO ASN ILE ASP SER PRO LEU ASN THR HIS ALA ALA GLU          
SEQRES  13 U  188  LEU TRP LYS ASN PRO THR ALA PHE LYS LYS TYR LEU GLN          
SEQRES  14 U  188  GLU THR TYR SER LYS GLN VAL THR SER GLN GLU PRO TRP          
SEQRES  15 U  188  SER HIS PRO GLN GLU LYS                                      
SEQRES   1 W   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 W   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 W   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 W   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 W   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 W   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 W   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 X  565  MET ASN VAL ILE ASP HIS VAL ARG ASP MET ALA ALA ALA          
SEQRES   2 X  565  GLY LEU HIS SER ASN VAL ARG LEU LEU SER SER LEU LEU          
SEQRES   3 X  565  LEU THR MET SER ASN ASN ASN PRO GLU LEU PHE SER PRO          
SEQRES   4 X  565  PRO GLN LYS TYR GLN LEU LEU VAL TYR HIS ALA ASP SER          
SEQRES   5 X  565  LEU PHE HIS ASP LYS GLU TYR ARG ASN ALA VAL SER LYS          
SEQRES   6 X  565  TYR THR MET ALA LEU GLN GLN LYS LYS ALA LEU SER LYS          
SEQRES   7 X  565  THR SER LYS VAL ARG PRO SER THR GLY ASN SER ALA SER          
SEQRES   8 X  565  THR PRO GLN SER GLN CYS LEU PRO SER GLU ILE GLU VAL          
SEQRES   9 X  565  LYS TYR LYS MET ALA GLU CYS TYR THR MET LEU LYS GLN          
SEQRES  10 X  565  ASP LYS ASP ALA ILE ALA ILE LEU ASP GLY ILE PRO SER          
SEQRES  11 X  565  ARG GLN ARG THR PRO LYS ILE ASN MET MET LEU ALA ASN          
SEQRES  12 X  565  LEU TYR LYS LYS ALA GLY GLN GLU ARG PRO SER VAL THR          
SEQRES  13 X  565  SER TYR LYS GLU VAL LEU ARG GLN CYS PRO LEU ALA LEU          
SEQRES  14 X  565  ASP ALA ILE LEU GLY LEU LEU SER LEU SER VAL LYS GLY          
SEQRES  15 X  565  ALA GLU VAL ALA SER MET THR MET ASN VAL ILE GLN THR          
SEQRES  16 X  565  VAL PRO ASN LEU ASP TRP LEU SER VAL TRP ILE LYS ALA          
SEQRES  17 X  565  TYR ALA PHE VAL HIS THR GLY ASP ASN SER ARG ALA ILE          
SEQRES  18 X  565  SER THR ILE CYS SER LEU GLU LYS LYS SER LEU LEU ARG          
SEQRES  19 X  565  ASP ASN VAL ASP LEU LEU GLY SER LEU ALA ASP LEU TYR          
SEQRES  20 X  565  PHE ARG ALA GLY ASP ASN LYS ASN SER VAL LEU LYS PHE          
SEQRES  21 X  565  GLU GLN ALA GLN MET LEU ASP PRO TYR LEU ILE LYS GLY          
SEQRES  22 X  565  MET ASP VAL TYR GLY TYR LEU LEU ALA ARG GLU GLY ARG          
SEQRES  23 X  565  LEU GLU ASP VAL GLU ASN LEU GLY CYS ARG LEU PHE ASN          
SEQRES  24 X  565  ILE SER ASP GLN HIS ALA GLU PRO TRP VAL VAL SER GLY          
SEQRES  25 X  565  CYS HIS SER PHE TYR SER LYS ARG TYR SER ARG ALA LEU          
SEQRES  26 X  565  TYR LEU GLY ALA LYS ALA ILE GLN LEU ASN SER ASN SER          
SEQRES  27 X  565  VAL GLN ALA LEU LEU LEU LYS GLY ALA ALA LEU ARG ASN          
SEQRES  28 X  565  MET GLY ARG VAL GLN GLU ALA ILE ILE HIS PHE ARG GLU          
SEQRES  29 X  565  ALA ILE ARG LEU ALA PRO CYS ARG LEU ASP CYS TYR GLU          
SEQRES  30 X  565  GLY LEU ILE GLU CYS TYR LEU ALA SER ASN SER ILE ARG          
SEQRES  31 X  565  GLU ALA MET VAL MET ALA ASN ASN VAL TYR LYS THR LEU          
SEQRES  32 X  565  GLY ALA ASN ALA GLN THR LEU THR LEU LEU ALA THR VAL          
SEQRES  33 X  565  CYS LEU GLU ASP PRO VAL THR GLN GLU LYS ALA LYS THR          
SEQRES  34 X  565  LEU LEU ASP LYS ALA LEU THR GLN ARG PRO ASP TYR ILE          
SEQRES  35 X  565  LYS ALA VAL VAL LYS LYS ALA GLU LEU LEU SER ARG GLU          
SEQRES  36 X  565  GLN LYS TYR GLU ASP GLY ILE ALA LEU LEU ARG ASN ALA          
SEQRES  37 X  565  LEU ALA ASN GLN SER ASP CYS VAL LEU HIS ARG ILE LEU          
SEQRES  38 X  565  GLY ASP PHE LEU VAL ALA VAL ASN GLU TYR GLN GLU ALA          
SEQRES  39 X  565  MET ASP GLN TYR SER ILE ALA LEU SER LEU ASP PRO ASN          
SEQRES  40 X  565  ASP GLN LYS SER LEU GLU GLY MET GLN LYS MET GLU LYS          
SEQRES  41 X  565  GLU GLU SER PRO THR ASP ALA THR GLN GLU GLU ASP VAL          
SEQRES  42 X  565  ASP ASP MET GLU GLY SER GLY GLU GLU GLY ASP LEU GLU          
SEQRES  43 X  565  GLY SER ASP SER GLU ALA ALA GLN TRP ALA ASP GLN GLU          
SEQRES  44 X  565  GLN TRP PHE GLY MET GLN                                      
SEQRES   1 Y  565  MET ASN VAL ILE ASP HIS VAL ARG ASP MET ALA ALA ALA          
SEQRES   2 Y  565  GLY LEU HIS SER ASN VAL ARG LEU LEU SER SER LEU LEU          
SEQRES   3 Y  565  LEU THR MET SER ASN ASN ASN PRO GLU LEU PHE SER PRO          
SEQRES   4 Y  565  PRO GLN LYS TYR GLN LEU LEU VAL TYR HIS ALA ASP SER          
SEQRES   5 Y  565  LEU PHE HIS ASP LYS GLU TYR ARG ASN ALA VAL SER LYS          
SEQRES   6 Y  565  TYR THR MET ALA LEU GLN GLN LYS LYS ALA LEU SER LYS          
SEQRES   7 Y  565  THR SER LYS VAL ARG PRO SER THR GLY ASN SER ALA SER          
SEQRES   8 Y  565  THR PRO GLN SER GLN CYS LEU PRO SER GLU ILE GLU VAL          
SEQRES   9 Y  565  LYS TYR LYS MET ALA GLU CYS TYR THR MET LEU LYS GLN          
SEQRES  10 Y  565  ASP LYS ASP ALA ILE ALA ILE LEU ASP GLY ILE PRO SER          
SEQRES  11 Y  565  ARG GLN ARG THR PRO LYS ILE ASN MET MET LEU ALA ASN          
SEQRES  12 Y  565  LEU TYR LYS LYS ALA GLY GLN GLU ARG PRO SER VAL THR          
SEQRES  13 Y  565  SER TYR LYS GLU VAL LEU ARG GLN CYS PRO LEU ALA LEU          
SEQRES  14 Y  565  ASP ALA ILE LEU GLY LEU LEU SER LEU SER VAL LYS GLY          
SEQRES  15 Y  565  ALA GLU VAL ALA SER MET THR MET ASN VAL ILE GLN THR          
SEQRES  16 Y  565  VAL PRO ASN LEU ASP TRP LEU SER VAL TRP ILE LYS ALA          
SEQRES  17 Y  565  TYR ALA PHE VAL HIS THR GLY ASP ASN SER ARG ALA ILE          
SEQRES  18 Y  565  SER THR ILE CYS SER LEU GLU LYS LYS SER LEU LEU ARG          
SEQRES  19 Y  565  ASP ASN VAL ASP LEU LEU GLY SER LEU ALA ASP LEU TYR          
SEQRES  20 Y  565  PHE ARG ALA GLY ASP ASN LYS ASN SER VAL LEU LYS PHE          
SEQRES  21 Y  565  GLU GLN ALA GLN MET LEU ASP PRO TYR LEU ILE LYS GLY          
SEQRES  22 Y  565  MET ASP VAL TYR GLY TYR LEU LEU ALA ARG GLU GLY ARG          
SEQRES  23 Y  565  LEU GLU ASP VAL GLU ASN LEU GLY CYS ARG LEU PHE ASN          
SEQRES  24 Y  565  ILE SER ASP GLN HIS ALA GLU PRO TRP VAL VAL SER GLY          
SEQRES  25 Y  565  CYS HIS SER PHE TYR SER LYS ARG TYR SER ARG ALA LEU          
SEQRES  26 Y  565  TYR LEU GLY ALA LYS ALA ILE GLN LEU ASN SER ASN SER          
SEQRES  27 Y  565  VAL GLN ALA LEU LEU LEU LYS GLY ALA ALA LEU ARG ASN          
SEQRES  28 Y  565  MET GLY ARG VAL GLN GLU ALA ILE ILE HIS PHE ARG GLU          
SEQRES  29 Y  565  ALA ILE ARG LEU ALA PRO CYS ARG LEU ASP CYS TYR GLU          
SEQRES  30 Y  565  GLY LEU ILE GLU CYS TYR LEU ALA SER ASN SER ILE ARG          
SEQRES  31 Y  565  GLU ALA MET VAL MET ALA ASN ASN VAL TYR LYS THR LEU          
SEQRES  32 Y  565  GLY ALA ASN ALA GLN THR LEU THR LEU LEU ALA THR VAL          
SEQRES  33 Y  565  CYS LEU GLU ASP PRO VAL THR GLN GLU LYS ALA LYS THR          
SEQRES  34 Y  565  LEU LEU ASP LYS ALA LEU THR GLN ARG PRO ASP TYR ILE          
SEQRES  35 Y  565  LYS ALA VAL VAL LYS LYS ALA GLU LEU LEU SER ARG GLU          
SEQRES  36 Y  565  GLN LYS TYR GLU ASP GLY ILE ALA LEU LEU ARG ASN ALA          
SEQRES  37 Y  565  LEU ALA ASN GLN SER ASP CYS VAL LEU HIS ARG ILE LEU          
SEQRES  38 Y  565  GLY ASP PHE LEU VAL ALA VAL ASN GLU TYR GLN GLU ALA          
SEQRES  39 Y  565  MET ASP GLN TYR SER ILE ALA LEU SER LEU ASP PRO ASN          
SEQRES  40 Y  565  ASP GLN LYS SER LEU GLU GLY MET GLN LYS MET GLU LYS          
SEQRES  41 Y  565  GLU GLU SER PRO THR ASP ALA THR GLN GLU GLU ASP VAL          
SEQRES  42 Y  565  ASP ASP MET GLU GLY SER GLY GLU GLU GLY ASP LEU GLU          
SEQRES  43 Y  565  GLY SER ASP SER GLU ALA ALA GLN TRP ALA ASP GLN GLU          
SEQRES  44 Y  565  GLN TRP PHE GLY MET GLN                                      
HELIX    1   1 PHE A   23  HIS A   30  1                                   8    
HELIX    2   2 GLU A  616  ILE A  628  1                                  13    
HELIX    3   3 GLU A  632  SER A  646  1                                  15    
HELIX    4   4 GLU A  656  MET A  668  1                                  13    
HELIX    5   5 ASP A  705  ASN A  712  1                                   8    
HELIX    6   6 ASP A  714  SER A  721  1                                   8    
HELIX    7   7 ILE A  759  LYS A  774  1                                  16    
HELIX    8   8 GLY A  782  LEU A  797  1                                  16    
HELIX    9   9 PRO A  801  ASP A  809  1                                   9    
HELIX   10  10 ILE A  844  LYS A  853  1                                  10    
HELIX   11  11 GLU A  868  ILE A  881  1                                  14    
HELIX   12  12 SER A  925  ASN A  936  1                                  12    
HELIX   13  13 LEU A  941  GLU A  945  1                                   5    
HELIX   14  14 PHE A  949  GLU A  964  1                                  16    
HELIX   15  15 GLU A  972  LEU A  977  1                                   6    
HELIX   16  16 GLN A  981  LEU A  983  1                                   3    
HELIX   17  17 HIS A 1021  ILE A 1027  1                                   7    
HELIX   18  18 ARG A 1033  LEU A 1040  1                                   8    
HELIX   19  19 ASP A 1059  PHE A 1087  1                                  29    
HELIX   20  20 SER A 1133  LYS A 1146  1                                  14    
HELIX   21  21 SER A 1155  ASN A 1161  1                                   7    
HELIX   22  22 ALA A 1169  ASN A 1182  1                                  14    
HELIX   23  23 HIS A 1184  LYS A 1187  1                                   4    
HELIX   24  24 THR A 1190  LYS A 1199  1                                  10    
HELIX   25  25 GLU A 1202  LYS A 1216  1                                  15    
HELIX   26  26 MET A 1222  HIS A 1231  1                                  10    
HELIX   27  27 HIS A 1247  VAL A 1260  1                                  14    
HELIX   28  28 ARG A 1267  ILE A 1277  1                                  11    
HELIX   29  29 ARG A 1291  CYS A 1306  1                                  16    
HELIX   30  30 VAL A 1321  VAL A 1330  1                                  10    
HELIX   31  31 VAL A 1360  ILE A 1374  1                                  15    
HELIX   32  32 ARG A 1381  TRP A 1386  1                                   6    
HELIX   33  33 MET A 1393  PHE A 1398  1                                   6    
HELIX   34  34 PRO A 1401  ILE A 1414  1                                  14    
HELIX   35  35 SER A 1423  ASN A 1429  1                                   7    
HELIX   36  36 GLN A 1432  GLU A 1436  1                                   5    
HELIX   37  37 LEU A 1454  ARG A 1475  1                                  22    
HELIX   38  38 LEU A 1482  LEU A 1499  1                                  18    
HELIX   39  39 ALA A 1504  THR A 1507  1                                   4    
HELIX   40  40 PRO A 1509  MET A 1527  1                                  19    
HELIX   41  41 LEU A 1533  LYS A 1545  1                                  13    
HELIX   42  42 TYR A 1552  LEU A 1565  1                                  14    
HELIX   43  43 SER A 1579  ALA A 1587  1                                   9    
HELIX   44  44 GLN A 1604  ALA A 1613  1                                  10    
HELIX   45  45 GLN A 1685  SER A 1692  1                                   8    
HELIX   46  54 MET B   57  GLN B   67  1                                  11    
HELIX   47  55 LEU C   29  ARG C   46  1                                  18    
HELIX   48  56 LEU C   49  SER C   61  1                                  13    
HELIX   49  57 GLU C   78  ASP C   95  1                                  18    
HELIX   50  58 TYR C   99  GLY C  108  1                                  10    
HELIX   51  59 LYS C  112  ASP C  136  1                                  25    
HELIX   52  60 LEU C  151  ALA C  164  1                                  14    
HELIX   53  61 PHE C  170  LYS C  181  1                                  12    
HELIX   54  62 VAL C  185  VAL C  198  1                                  14    
HELIX   55  63 TRP C  203  LEU C  212  1                                  10    
HELIX   56  64 LYS C  216  PHE C  221  1                                   6    
HELIX   57  65 TRP C  228  LEU C  241  1                                  14    
HELIX   58  66 ILE C  244  PHE C  259  1                                  16    
HELIX   59  67 SER C  263  ASN C  275  1                                  13    
HELIX   60  68 ILE C  279  GLN C  292  1                                  14    
HELIX   61  69 MET C  300  VAL C  309  1                                  10    
HELIX   62  70 LYS C  313  ILE C  326  1                                  14    
HELIX   63  71 VAL C  331  ARG C  344  1                                  14    
HELIX   64  72 HIS C  347  LEU C  360  1                                  14    
HELIX   65  73 GLY C  366  GLU C  377  1                                  12    
HELIX   66  74 THR C  381  VAL C  394  1                                  14    
HELIX   67  75 TYR C  399  ILE C  411  1                                  13    
HELIX   68  76 PRO C  415  LEU C  428  1                                  14    
HELIX   69  77 SER C  433  LEU C  446  1                                  14    
HELIX   70  78 LEU C  449  VAL C  462  1                                  14    
HELIX   71  79 ALA C  469  GLN C  479  1                                  11    
HELIX   72  80 GLU C  484  TYR C  498  1                                  15    
HELIX   73  81 GLU D   26  ALA D   45  1                                  20    
HELIX   74  82 PHE E   53  ALA E   91  1                                  39    
HELIX   75  83 ILE E   99  LEU E  102  1                                   4    
HELIX   76  84 PRO F    7  ASN F   17  1                                  11    
HELIX   77  85 TYR F   21  VAL F   35  1                                  15    
HELIX   78  86 GLU F   38  ARG F   50  1                                  13    
HELIX   79  87 ALA F   54  GLY F   63  1                                  10    
HELIX   80  88 PRO F   69  ASP F   81  1                                  13    
HELIX   81  89 LEU F   85  SER F   93  1                                   9    
HELIX   82  90 ASP F  104  THR F  128  1                                  25    
HELIX   83  91 LEU F  131  LEU F  144  1                                  14    
HELIX   84  92 TRP F  149  GLU F  157  1                                   9    
HELIX   85  93 PHE F  452  SER F  478  1                                  27    
HELIX   86  94 CYS F  481  SER F  489  1                                   9    
HELIX   87  95 GLY F  499  GLU F  511  1                                  13    
HELIX   88  96 TYR F  515  ILE F  528  1                                  14    
HELIX   89  97 MET F  536  LEU F  546  1                                  11    
HELIX   90  98 ASP F  549  MET F  562  1                                  14    
HELIX   91  99 PRO F  567  LEU F  579  1                                  13    
HELIX   92 100 HIS F  583  VAL F  596  1                                  14    
HELIX   93 101 ALA F  601  THR F  614  1                                  14    
HELIX   94 102 LEU F  617  VAL F  630  1                                  14    
HELIX   95 103 TYR F  635  LYS F  647  1                                  13    
HELIX   96 104 PHE F  651  ILE F  664  1                                  14    
HELIX   97 105 SER F  669  LEU F  682  1                                  14    
HELIX   98 106 SER F  685  ILE F  698  1                                  14    
HELIX   99 107 PRO F  703  ALA F  715  1                                  13    
HELIX  100 108 TYR F  719  ILE F  732  1                                  14    
HELIX  101 109 SER F  737  LEU F  750  1                                  14    
HELIX  102 110 THR F  753  ASP F  765  1                                  13    
HELIX  103 111 LEU G   13  LYS G   24  1                                  12    
HELIX  104 112 PRO H    7  ASN H   17  1                                  11    
HELIX  105 113 TYR H   21  VAL H   35  1                                  15    
HELIX  106 114 GLU H   38  ARG H   50  1                                  13    
HELIX  107 115 ALA H   54  GLY H   63  1                                  10    
HELIX  108 116 PRO H   69  ASP H   81  1                                  13    
HELIX  109 117 LEU H   85  SER H   93  1                                   9    
HELIX  110 118 ASP H  104  THR H  128  1                                  25    
HELIX  111 119 LEU H  131  LEU H  144  1                                  14    
HELIX  112 120 TRP H  149  GLU H  157  1                                   9    
HELIX  113 121 PRO H  164  PHE H  168  1                                   5    
HELIX  114 122 PHE H  452  SER H  478  1                                  27    
HELIX  115 123 CYS H  481  HIS H  490  1                                  10    
HELIX  116 124 GLY H  499  GLU H  511  1                                  13    
HELIX  117 125 TYR H  515  ILE H  528  1                                  14    
HELIX  118 126 MET H  536  LEU H  546  1                                  11    
HELIX  119 127 ASP H  549  MET H  562  1                                  14    
HELIX  120 128 PRO H  567  LEU H  579  1                                  13    
HELIX  121 129 HIS H  583  VAL H  596  1                                  14    
HELIX  122 130 ALA H  601  THR H  614  1                                  14    
HELIX  123 131 LEU H  617  VAL H  630  1                                  14    
HELIX  124 132 TYR H  635  LYS H  647  1                                  13    
HELIX  125 133 PHE H  651  ILE H  664  1                                  14    
HELIX  126 134 SER H  669  LEU H  682  1                                  14    
HELIX  127 135 SER H  685  ILE H  698  1                                  14    
HELIX  128 136 PRO H  703  ALA H  715  1                                  13    
HELIX  129 137 TYR H  719  ILE H  732  1                                  14    
HELIX  130 138 SER H  737  LEU H  750  1                                  14    
HELIX  131 139 THR H  753  LEU H  766  1                                  14    
HELIX  132 140 ALA I   50  PHE I   52  1                                   3    
HELIX  133 141 ASP I  133  ASN I  136  1                                   4    
HELIX  134 142 ILE I  164  GLY I  169  1                                   6    
HELIX  135 143 ALA I  189  GLY I  191  1                                   3    
HELIX  136 144 ASN I  239  SER I  243  1                                   5    
HELIX  137 145 LEU I  245  GLU I  293  1                                  49    
HELIX  138 146 VAL I  300  LEU I  309  1                                  10    
HELIX  139 147 GLU I  316  GLN I  324  1                                   9    
HELIX  140 148 VAL I  327  SER I  371  1                                  45    
HELIX  141 149 LYS I  373  TYR I  376  1                                   4    
HELIX  142 150 ALA I  383  MET I  428  1                                  46    
HELIX  143 151 GLN I  442  HIS I  455  1                                  14    
HELIX  144 152 VAL I  475  LYS I  480  1                                   6    
HELIX  145 153 GLN I  496  GLN I  502  1                                   7    
HELIX  146 154 HIS I  506  GLU I  509  1                                   4    
HELIX  147 155 LEU I  522  SER I  547  1                                  26    
HELIX  148 156 LEU I  671  VAL I  674  1                                   4    
HELIX  149 157 SER I  680  GLU I  682  1                                   3    
HELIX  150 158 LEU J    3  GLN J   16  1                                  14    
HELIX  151 159 TYR J   19  SER J   33  1                                  15    
HELIX  152 160 PRO J   37  LEU J   49  1                                  13    
HELIX  153 161 TYR J   53  SER J   62  1                                  10    
HELIX  154 162 LEU J   65  TYR J   69  1                                   5    
HELIX  155 163 ALA J   71  ALA J   83  1                                  13    
HELIX  156 164 GLN J   88  LEU J   93  1                                   6    
HELIX  157 165 GLN J  125  LEU J  143  1                                  19    
HELIX  158 166 ARG J  146  ASP J  160  1                                  15    
HELIX  159 167 PHE J  164  HIS J  173  1                                  10    
HELIX  160 168 ALA J  178  SER J  187  1                                  10    
HELIX  161 169 ASN J  195  LYS J  208  1                                  14    
HELIX  162 170 LEU J  231  ASN J  244  1                                  14    
HELIX  163 171 PHE J  247  LYS J  260  1                                  14    
HELIX  164 172 CYS J  267  GLU J  277  1                                  11    
HELIX  165 173 ALA J  281  LEU J  294  1                                  14    
HELIX  166 174 PRO J  299  VAL J  312  1                                  14    
HELIX  167 175 ASN J  316  LEU J  329  1                                  14    
HELIX  168 176 GLY J  334  GLU J  347  1                                  14    
HELIX  169 177 HIS J  350  LEU J  363  1                                  14    
HELIX  170 178 LEU J  369  LEU J  380  1                                  12    
HELIX  171 179 SER J  384  SER J  396  1                                  13    
HELIX  172 180 PRO J  402  ASN J  415  1                                  14    
HELIX  173 181 LYS J  419  LYS J  433  1                                  15    
HELIX  174 182 GLU J  445  LYS J  457  1                                  13    
HELIX  175 183 TYR J  461  LEU J  474  1                                  14    
HELIX  176 184 ALA J  479  LEU J  491  1                                  13    
HELIX  177 185 PHE J  495  LEU J  508  1                                  14    
HELIX  178 186 THR J  513  ILE J  527  1                                  15    
HELIX  179 187 LEU K    3  GLN K   16  1                                  14    
HELIX  180 188 TYR K   19  SER K   33  1                                  15    
HELIX  181 189 PRO K   37  LEU K   49  1                                  13    
HELIX  182 190 TYR K   53  LEU K   68  1                                  16    
HELIX  183 191 GLU K   70  ALA K   82  1                                  13    
HELIX  184 192 GLN K   88  VAL K   92  1                                   5    
HELIX  185 193 LYS K  129  LEU K  143  1                                  15    
HELIX  186 194 ARG K  146  ASP K  160  1                                  15    
HELIX  187 195 PHE K  164  HIS K  174  1                                  11    
HELIX  188 196 GLN K  179  SER K  187  1                                   9    
HELIX  189 197 ASN K  195  LYS K  210  1                                  16    
HELIX  190 198 VAL K  219  VAL K  224  1                                   6    
HELIX  191 199 LEU K  227  GLU K  229  1                                   3    
HELIX  192 200 LEU K  231  ASN K  244  1                                  14    
HELIX  193 201 PHE K  247  LYS K  260  1                                  14    
HELIX  194 202 CYS K  267  GLU K  277  1                                  11    
HELIX  195 203 ALA K  281  LEU K  294  1                                  14    
HELIX  196 204 PRO K  299  VAL K  312  1                                  14    
HELIX  197 205 ASN K  316  LEU K  329  1                                  14    
HELIX  198 206 PRO K  335  GLU K  347  1                                  13    
HELIX  199 207 HIS K  350  LEU K  363  1                                  14    
HELIX  200 208 LEU K  369  LEU K  380  1                                  12    
HELIX  201 209 SER K  384  ILE K  397  1                                  14    
HELIX  202 210 PRO K  402  ASN K  415  1                                  14    
HELIX  203 211 TRP K  418  ALA K  434  1                                  17    
HELIX  204 212 VAL K  441  LYS K  457  1                                  17    
HELIX  205 213 TYR K  461  LEU K  474  1                                  14    
HELIX  206 214 ALA K  479  LEU K  491  1                                  13    
HELIX  207 215 PHE K  495  LEU K  508  1                                  14    
HELIX  208 216 THR K  513  TYR K  526  1                                  14    
HELIX  209 217 PRO L   13  THR L   19  1                                   7    
HELIX  210 218 VAL L   42  ASP L   47  1                                   6    
HELIX  211 219 HIS L  145  ASN L  147  1                                   3    
HELIX  212 220 ILE L  175  TYR L  180  1                                   6    
HELIX  213 221 GLY M    9  ILE M   15  1                                   7    
HELIX  214 222 GLU M   52  MET M   55  1                                   4    
HELIX  215 223 VAL N   22  SER N   28  1                                   7    
HELIX  216 224 GLN N   80  PHE N   91  1                                  12    
HELIX  217 225 ASN N   93  CYS N   98  1                                   6    
HELIX  218 226 LEU N  108  LEU N  122  1                                  15    
HELIX  219 227 ARG N  127  LEU N  138  1                                  12    
HELIX  220 228 GLU N  151  PHE N  162  1                                  12    
HELIX  221 229 ARG N  167  ARG N  189  1                                  23    
HELIX  222 230 GLN N  235  ARG N  249  1                                  15    
HELIX  223 231 GLU N  288  VAL N  303  1                                  16    
HELIX  224 232 ARG N  322  ARG N  349  1                                  28    
HELIX  225 233 ARG N  355  GLU N  366  1                                  12    
HELIX  226 234 ARG N  371  ARG N  385  1                                  15    
HELIX  227 235 THR N  393  ARG N  408  1                                  16    
HELIX  228 236 VAL N  415  ALA N  420  1                                   6    
HELIX  229 237 GLU N  422  ARG N  431  1                                  10    
HELIX  230 238 THR N  434  GLY N  441  1                                   8    
HELIX  231 239 LEU N  452  SER N  457  1                                   6    
HELIX  232 240 ASP N  500  TYR N  509  1                                  10    
HELIX  233 241 ARG N  537  ARG N  548  1                                  12    
HELIX  234 242 MET N  554  GLU N  579  1                                  26    
HELIX  235 243 ARG N  581  ALA N  583  1                                   3    
HELIX  236 244 GLU N  613  GLN N  628  1                                  16    
HELIX  237 245 HIS N  639  LEU N  641  1                                   3    
HELIX  238 246 PRO N  661  GLN N  671  1                                  11    
HELIX  239 247 LEU N  678  VAL N  685  1                                   8    
HELIX  240 248 VAL N  689  GLN N  702  1                                  14    
HELIX  241 249 LEU N  752  LEU N  765  1                                  14    
HELIX  242 250 LEU N  770  VAL N  782  1                                  13    
HELIX  243 251 LEU N  792  ARG N  804  1                                  13    
HELIX  244 252 PRO O   32  MET O   44  1                                  13    
HELIX  245 253 LEU O   54  GLN O   69  1                                  16    
HELIX  246 254 LEU O   75  SER O   85  1                                  11    
HELIX  247 255 LEU O   89  GLU O  102  1                                  14    
HELIX  248 256 LEU O  105  SER O  120  1                                  16    
HELIX  249 257 SER O  130  LYS O  145  1                                  16    
HELIX  250 258 PHE O  148  LYS O  168  1                                  21    
HELIX  251 259 GLN O  209  ASN O  225  1                                  17    
HELIX  252 260 PRO O  233  PHE O  246  1                                  14    
HELIX  253 261 ALA O  251  VAL O  264  1                                  14    
HELIX  254 262 VAL O  267  ARG O  280  1                                  14    
HELIX  255 263 ARG O  298  ARG O  313  1                                  16    
HELIX  256 264 TYR O  317  SER O  334  1                                  18    
HELIX  257 265 HIS O  337  LEU O  350  1                                  14    
HELIX  258 266 TYR O  358  VAL O  369  1                                  12    
HELIX  259 267 PRO O  374  ALA O  391  1                                  18    
HELIX  260 268 ALA O  395  HIS O  412  1                                  18    
HELIX  261 269 SER O  415  LEU O  431  1                                  17    
HELIX  262 270 SER O  435  SER O  447  1                                  13    
HELIX  263 271 THR O  463  GLU O  479  1                                  17    
HELIX  264 272 PHE O  483  ARG O  496  1                                  14    
HELIX  265 273 ALA O  504  ASP O  522  1                                  19    
HELIX  266 274 TYR O  525  ASN O  539  1                                  15    
HELIX  267 275 ILE O  541  GLN O  554  1                                  14    
HELIX  268 276 MET O  557  LEU O  574  1                                  18    
HELIX  269 277 THR O  577  SER O  594  1                                  18    
HELIX  270 278 PRO O  597  GLU O  613  1                                  17    
HELIX  271 279 GLN O  617  ILE O  633  1                                  17    
HELIX  272 280 PRO O  637  ALA O  653  1                                  17    
HELIX  273 281 LEU O  658  SER O  677  1                                  20    
HELIX  274 282 LYS O  683  VAL O  704  1                                  22    
HELIX  275 283 GLU O  708  LEU O  724  1                                  17    
HELIX  276 284 THR O  727  GLN O  742  1                                  16    
HELIX  277 285 LEU P   29  ARG P   46  1                                  18    
HELIX  278 286 LEU P   49  SER P   61  1                                  13    
HELIX  279 287 GLU P   78  ASP P   95  1                                  18    
HELIX  280 288 TYR P   99  GLY P  108  1                                  10    
HELIX  281 289 LYS P  112  GLU P  133  1                                  22    
HELIX  282 290 GLU P  149  ALA P  164  1                                  16    
HELIX  283 291 PHE P  170  LYS P  181  1                                  12    
HELIX  284 292 VAL P  185  VAL P  198  1                                  14    
HELIX  285 293 TRP P  203  LEU P  212  1                                  10    
HELIX  286 294 LYS P  216  PHE P  221  1                                   6    
HELIX  287 295 TRP P  228  GLU P  240  1                                  13    
HELIX  288 296 ILE P  244  PHE P  259  1                                  16    
HELIX  289 297 SER P  263  ASN P  275  1                                  13    
HELIX  290 298 ILE P  279  GLN P  292  1                                  14    
HELIX  291 299 MET P  300  VAL P  309  1                                  10    
HELIX  292 300 LYS P  313  ILE P  326  1                                  14    
HELIX  293 301 VAL P  331  ARG P  344  1                                  14    
HELIX  294 302 HIS P  347  LEU P  360  1                                  14    
HELIX  295 303 LEU P  365  GLU P  377  1                                  13    
HELIX  296 304 THR P  381  VAL P  394  1                                  14    
HELIX  297 305 TYR P  399  ILE P  411  1                                  13    
HELIX  298 306 PHE P  416  LEU P  428  1                                  13    
HELIX  299 307 SER P  433  LEU P  446  1                                  14    
HELIX  300 308 LEU P  449  ALA P  461  1                                  13    
HELIX  301 309 TRP R   57  HIS R   62  1                                   6    
HELIX  302 310 LEU R   89  LEU R   99  1                                  11    
HELIX  303 311 ASN R  155  ARG R  162  1                                   8    
HELIX  304 312 PHE R  489  ARG R  491  1                                   3    
HELIX  305 313 ILE S  875  GLU S  886  1                                  12    
HELIX  306 314 LEU S  908  TYR S  911  1                                   4    
HELIX  307 315 GLY U   29  SER U   45  1                                  17    
HELIX  308 316 ASP U  116  LYS U  119  1                                   4    
HELIX  309 317 VAL U  128  GLY U  140  1                                  13    
HELIX  310 318 THR U  150  LYS U  157  1                                   8    
HELIX  311 319 PRO U  159  TYR U  170  1                                  12    
HELIX  312 320 LEU W   13  LYS W   24  1                                  12    
HELIX  313 321 VAL X   37  ALA X   47  1                                  11    
HELIX  314 322 HIS X   50  ASN X   66  1                                  17    
HELIX  315 323 PRO X   73  HIS X   89  1                                  17    
HELIX  316 324 TYR X   93  ALA X  109  1                                  17    
HELIX  317 325 GLU X  135  LEU X  149  1                                  15    
HELIX  318 326 ASP X  152  ASP X  160  1                                   9    
HELIX  319 327 PRO X  169  ALA X  182  1                                  14    
HELIX  320 328 GLU X  185  GLN X  198  1                                  14    
HELIX  321 329 LEU X  203  LEU X  212  1                                  10    
HELIX  322 330 LYS X  215  GLN X  228  1                                  14    
HELIX  323 331 LEU X  236  THR X  248  1                                  13    
HELIX  324 332 ASN X  251  LYS X  263  1                                  13    
HELIX  325 333 VAL X  271  ALA X  284  1                                  14    
HELIX  326 334 ASN X  287  LEU X  300  1                                  14    
HELIX  327 335 ILE X  305  GLU X  318  1                                  14    
HELIX  328 336 LEU X  321  ILE X  334  1                                  14    
HELIX  329 337 ALA X  339  SER X  352  1                                  14    
HELIX  330 338 TYR X  355  LEU X  368  1                                  14    
HELIX  331 339 VAL X  373  MET X  386  1                                  14    
HELIX  332 340 VAL X  389  LEU X  402  1                                  14    
HELIX  333 341 LEU X  407  SER X  420  1                                  14    
HELIX  334 342 ILE X  423  LYS X  435  1                                  13    
HELIX  335 343 VAL Y   37  ALA Y   47  1                                  11    
HELIX  336 344 HIS Y   50  ASN Y   66  1                                  17    
HELIX  337 345 PRO Y   73  HIS Y   89  1                                  17    
HELIX  338 346 TYR Y   93  ALA Y  109  1                                  17    
HELIX  339 347 GLU Y  135  LEU Y  149  1                                  15    
HELIX  340 348 ASP Y  152  GLY Y  161  1                                  10    
HELIX  341 349 PRO Y  169  ALA Y  182  1                                  14    
HELIX  342 350 GLU Y  185  GLN Y  198  1                                  14    
HELIX  343 351 LEU Y  203  LEU Y  212  1                                  10    
HELIX  344 352 LYS Y  215  GLN Y  228  1                                  14    
HELIX  345 353 LEU Y  236  THR Y  248  1                                  13    
HELIX  346 354 ASN Y  251  LYS Y  263  1                                  13    
HELIX  347 355 VAL Y  271  ALA Y  284  1                                  14    
HELIX  348 356 ASN Y  287  LEU Y  300  1                                  14    
HELIX  349 357 ILE Y  305  GLU Y  318  1                                  14    
HELIX  350 358 LEU Y  321  ILE Y  334  1                                  14    
HELIX  351 359 ALA Y  339  SER Y  352  1                                  14    
HELIX  352 360 TYR Y  355  LEU Y  368  1                                  14    
HELIX  353 361 VAL Y  373  MET Y  386  1                                  14    
HELIX  354 362 VAL Y  389  LEU Y  402  1                                  14    
HELIX  355 363 LEU Y  407  SER Y  420  1                                  14    
HELIX  356 364 ILE Y  423  LEU Y  437  1                                  15    
HELIX  357 365 GLN Y  442  GLU Y  453  1                                  12    
SHEET    1   1 1 LEU A  17  GLU A  19  0                                        
SHEET    1   2 1 SER A  73  LYS A  78  0                                        
SHEET    1   3 1 ASP A  90  VAL A  95  0                                        
SHEET    1   4 1 MET A  99  SER A 103  0                                        
SHEET    1   5 1 LYS A 115  THR A 118  0                                        
SHEET    1   6 1 TRP A 128  PHE A 131  0                                        
SHEET    1   7 1 GLU A 148  LEU A 154  0                                        
SHEET    1   8 1 ILE A 159  SER A 163  0                                        
SHEET    1   9 1 ASP A 168  ILE A 170  0                                        
SHEET    1  10 1 VAL A 177  VAL A 180  0                                        
SHEET    1  11 1 LEU A 187  ARG A 191  0                                        
SHEET    1  12 1 MET A 210  MET A 213  0                                        
SHEET    1  13 1 LYS A 245  ASN A 250  0                                        
SHEET    1  14 1 ILE A 255  ASP A 260  0                                        
SHEET    1  15 1 VAL A 265  LEU A 271  0                                        
SHEET    1  16 1 ILE A 409  TRP A 413  0                                        
SHEET    1  17 1 LYS A 429  SER A 434  0                                        
SHEET    1  18 1 LYS A 440  VAL A 446  0                                        
SHEET    1  19 1 GLN A 451  GLU A 459  0                                        
SHEET    1  20 1 LEU A 466  PHE A 468  0                                        
SHEET    1  21 1 VAL A 471  ILE A 474  0                                        
SHEET    1  22 1 ASP A 478  VAL A 482  0                                        
SHEET    1  23 1 THR A 487  GLU A 492  0                                        
SHEET    1  24 1 ASN A 496  TYR A 500  0                                        
SHEET    1  25 1 ARG A 505  LYS A 508  0                                        
SHEET    1  26 1 ILE A 584  ARG A 588  0                                        
SHEET    1  27 1 ARG A 594  LEU A 599  0                                        
SHEET    1  28 1 MET A 604  THR A 608  0                                        
SHEET    1  29 1 THR A1108  ALA A1111  0                                        
SHEET    1  30 1 THR A1116  ASP A1119  0                                        
SHEET    1  31 1 TYR A1572  LEU A1574  0                                        
SHEET    1  32 1 ALA A1614  PRO A1616  0                                        
SHEET    1  33 1 VAL A1620  VAL A1622  0                                        
SHEET    1  34 1 LEU A1633  LYS A1639  0                                        
SHEET    1  35 1 GLN A1646  MET A1652  0                                        
SHEET    1  36 1 LEU A1663  VAL A1668  0                                        
SHEET    1  37 1 GLU A1675  ILE A1678  0                                        
SHEET    1  38 1 VAL A1696  TYR A1698  0                                        
SHEET    1  39 1 VAL B   3  ASN B   9  0                                        
SHEET    1  40 1 LEU B  46  TRP B  48  0                                        
SHEET    1  41 1 CYS B  54  HIS B  56  0                                        
SHEET    1  42 1 ILE I  23  TRP I  28  0                                        
SHEET    1  43 1 ILE I  35  ASN I  39  0                                        
SHEET    1  44 1 VAL I  44  HIS I  47  0                                        
SHEET    1  45 1 ARG I  54  PHE I  58  0                                        
SHEET    1  46 1 VAL I  68  TRP I  73  0                                        
SHEET    1  47 1 LEU I  79  LEU I  84  0                                        
SHEET    1  48 1 ILE I  90  ASP I  94  0                                        
SHEET    1  49 1 SER I 100  PHE I 104  0                                        
SHEET    1  50 1 CYS I 112  TRP I 115  0                                        
SHEET    1  51 1 LEU I 176  GLY I 179  0                                        
SHEET    1  52 1 PHE I 184  ALA I 189  0                                        
SHEET    1  53 1 PHE I 193  THR I 199  0                                        
SHEET    1  54 1 THR I 204  LEU I 210  0                                        
SHEET    1  55 1 SER I 216  GLU I 222  0                                        
SHEET    1  56 1 TYR I 233  GLU I 237  0                                        
SHEET    1  57 1 ALA I 551  ILE I 554  0                                        
SHEET    1  58 1 PHE I 574  ASN I 578  0                                        
SHEET    1  59 1 LEU I 583  LEU I 591  0                                        
SHEET    1  60 1 TYR I 596  HIS I 604  0                                        
SHEET    1  61 1 LEU I 615  PHE I 623  0                                        
SHEET    1  62 1 TYR I 636  PHE I 643  0                                        
SHEET    1  63 1 THR I 648  ASP I 655  0                                        
SHEET    1  64 1 ARG I 664  PRO I 670  0                                        
SHEET    1  65 1 THR I 702  PHE I 707  0                                        
SHEET    1  66 1 TRP I 711  LEU I 713  0                                        
SHEET    1  67 1 ALA I 719  GLY I 724  0                                        
SHEET    1  68 1 VAL I 730  SER I 735  0                                        
SHEET    1  69 1 VAL I 741  GLU I 745  0                                        
SHEET    1  70 1 VAL L  22  GLU L  24  0                                        
SHEET    1  71 1 VAL L  30  LEU L  33  0                                        
SHEET    1  72 1 HIS L  62  GLN L  67  0                                        
SHEET    1  73 1 THR L  72  VAL L  74  0                                        
SHEET    1  74 1 THR L  76  TYR L  80  0                                        
SHEET    1  75 1 LYS L  93  GLY L  99  0                                        
SHEET    1  76 1 GLN L 106  GLU L 112  0                                        
SHEET    1  77 1 TRP L 119  PRO L 123  0                                        
SHEET    1  78 1 THR L 132  THR L 134  0                                        
SHEET    1  79 1 MET L 136  VAL L 141  0                                        
SHEET    1  80 1 GLN L 155  PRO L 161  0                                        
SHEET    1  81 1 LEU N 643  VAL N 648  0                                        
SHEET    1  82 1 LYS R 177  ASP R 180  0                                        
SHEET    1  83 1 VAL R 193  TRP R 195  0                                        
SHEET    1  84 1 VAL R 200  LEU R 205  0                                        
SHEET    1  85 1 CYS R 208  SER R 213  0                                        
SHEET    1  86 1 VAL R 219  ASP R 224  0                                        
SHEET    1  87 1 VAL R 232  TRP R 237  0                                        
SHEET    1  88 1 LEU R 243  THR R 248  0                                        
SHEET    1  89 1 VAL R 253  ASP R 257  0                                        
SHEET    1  90 1 LYS R 262  LEU R 267  0                                        
SHEET    1  91 1 VAL R 274  ASN R 280  0                                        
SHEET    1  92 1 GLN R 283  SER R 288  0                                        
SHEET    1  93 1 MET R 292  ASP R 297  0                                        
SHEET    1  94 1 GLN R 304  LEU R 309  0                                        
SHEET    1  95 1 LEU R 319  TRP R 321  0                                        
SHEET    1  96 1 LEU R 327  GLY R 331  0                                        
SHEET    1  97 1 LEU R 337  ASN R 341  0                                        
SHEET    1  98 1 GLN R 349  TYR R 351  0                                        
SHEET    1  99 1 ALA R 360  TRP R 363  0                                        
SHEET    1 100 1 LEU R 370  GLY R 374  0                                        
SHEET    1 101 1 CYS R 381  ASN R 386  0                                        
SHEET    1 102 1 PRO R 392  ASP R 397  0                                        
SHEET    1 103 1 VAL R 402  TRP R 407  0                                        
SHEET    1 104 1 GLU R 413  HIS R 418  0                                        
SHEET    1 105 1 ILE R 425  LYS R 429  0                                        
SHEET    1 106 1 TYR R 448  MET R 451  0                                        
SHEET    1 107 1 ALA R 457  ALA R 462  0                                        
SHEET    1 108 1 THR R 466  ASN R 471  0                                        
SHEET    1 109 1 MET S 853  LYS S 858  0                                        
SHEET    1 110 1 THR S 864  VAL S 869  0                                        
SHEET    1 111 1 GLN S 893  PHE S 897  0                                        
SHEET    1 112 1 LYS S 900  LEU S 902  0                                        
SHEET    1 113 1 SER S 917  MET S 923  0                                        
SHEET    1 114 1 ILE U  50  GLU U  55  0                                        
SHEET    1 115 1 ASN U  58  HIS U  67  0                                        
SHEET    1 116 1 ARG U  78  GLU U  84  0                                        
SHEET    1 117 1 THR U  95  PHE U  98  0                                        
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system