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Database: PDB
Entry: 5LCW
LinkDB: 5LCW
Original site: 5LCW 
HEADER    CELL CYCLE                              22-JUN-16   5LCW              
TITLE     CRYO-EM STRUCTURE OF THE ANAPHASE-PROMOTING COMPLEX/CYCLOSOME, IN     
TITLE    2 COMPLEX WITH THE MITOTIC CHECKPOINT COMPLEX (APC/C-MCC) AT 4.2       
TITLE    3 ANGSTROM RESOLUTION                                                  
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1;                      
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: APC1,CYCLOSOME SUBUNIT 1,MITOTIC CHECKPOINT REGULATOR,      
COMPND   5 TESTIS-SPECIFIC GENE 24 PROTEIN;                                     
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 11;                     
COMPND   9 CHAIN: B;                                                            
COMPND  10 SYNONYM: APC11,CYCLOSOME SUBUNIT 11,HEPATOCELLULAR CARCINOMA-        
COMPND  11 ASSOCIATED RING FINGER PROTEIN;                                      
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: CELL DIVISION CYCLE PROTEIN 23 HOMOLOG;                    
COMPND  15 CHAIN: C, P;                                                         
COMPND  16 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 8,APC8,CYCLOSOME SUBUNIT 
COMPND  17 8;                                                                   
COMPND  18 ENGINEERED: YES;                                                     
COMPND  19 MOL_ID: 4;                                                           
COMPND  20 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 15;                     
COMPND  21 CHAIN: D;                                                            
COMPND  22 SYNONYM: APC15;                                                      
COMPND  23 ENGINEERED: YES;                                                     
COMPND  24 MOL_ID: 5;                                                           
COMPND  25 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 16;                     
COMPND  26 CHAIN: E;                                                            
COMPND  27 SYNONYM: APC16,CYCLOSOME SUBUNIT 16;                                 
COMPND  28 ENGINEERED: YES;                                                     
COMPND  29 MOL_ID: 6;                                                           
COMPND  30 MOLECULE: CELL DIVISION CYCLE PROTEIN 27 HOMOLOG;                    
COMPND  31 CHAIN: F, H;                                                         
COMPND  32 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 3,APC3,CDC27 HOMOLOG,    
COMPND  33 CDC27HS,H-NUC;                                                       
COMPND  34 ENGINEERED: YES;                                                     
COMPND  35 MOL_ID: 7;                                                           
COMPND  36 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26;                  
COMPND  37 CHAIN: G, W;                                                         
COMPND  38 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 12,APC12,CELL DIVISION   
COMPND  39 CYCLE PROTEIN 26 HOMOLOG;                                            
COMPND  40 ENGINEERED: YES;                                                     
COMPND  41 MOL_ID: 8;                                                           
COMPND  42 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 4;                      
COMPND  43 CHAIN: I;                                                            
COMPND  44 SYNONYM: APC4,CYCLOSOME SUBUNIT 4;                                   
COMPND  45 ENGINEERED: YES;                                                     
COMPND  46 MOL_ID: 9;                                                           
COMPND  47 MOLECULE: CELL DIVISION CYCLE PROTEIN 16 HOMOLOG;                    
COMPND  48 CHAIN: J, K;                                                         
COMPND  49 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 6,APC6,CDC16 HOMOLOG,    
COMPND  50 CDC16HS,CYCLOSOME SUBUNIT 6;                                         
COMPND  51 ENGINEERED: YES;                                                     
COMPND  52 MOL_ID: 10;                                                          
COMPND  53 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 10;                     
COMPND  54 CHAIN: L;                                                            
COMPND  55 SYNONYM: APC10,CYCLOSOME SUBUNIT 10;                                 
COMPND  56 ENGINEERED: YES;                                                     
COMPND  57 MOL_ID: 11;                                                          
COMPND  58 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 13;                     
COMPND  59 CHAIN: M;                                                            
COMPND  60 SYNONYM: APC13,CYCLOSOME SUBUNIT 13;                                 
COMPND  61 ENGINEERED: YES;                                                     
COMPND  62 MOL_ID: 12;                                                          
COMPND  63 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 2;                      
COMPND  64 CHAIN: N;                                                            
COMPND  65 SYNONYM: APC2,CYCLOSOME SUBUNIT 2;                                   
COMPND  66 ENGINEERED: YES;                                                     
COMPND  67 MOL_ID: 13;                                                          
COMPND  68 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 5;                      
COMPND  69 CHAIN: O;                                                            
COMPND  70 SYNONYM: APC5,CYCLOSOME SUBUNIT 5;                                   
COMPND  71 ENGINEERED: YES;                                                     
COMPND  72 MOL_ID: 14;                                                          
COMPND  73 MOLECULE: CELL DIVISION CYCLE PROTEIN 20 HOMOLOG;                    
COMPND  74 CHAIN: Q;                                                            
COMPND  75 SYNONYM: P55CDC;                                                     
COMPND  76 ENGINEERED: YES;                                                     
COMPND  77 MOL_ID: 15;                                                          
COMPND  78 MOLECULE: CELL DIVISION CYCLE PROTEIN 20 HOMOLOG;                    
COMPND  79 CHAIN: R;                                                            
COMPND  80 SYNONYM: P55CDC;                                                     
COMPND  81 ENGINEERED: YES;                                                     
COMPND  82 MOL_ID: 16;                                                          
COMPND  83 MOLECULE: MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1    
COMPND  84 BETA,MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 BETA;   
COMPND  85 CHAIN: S;                                                            
COMPND  86 SYNONYM: MAD3/BUB1-RELATED PROTEIN KINASE,HBUBR1,MITOTIC CHECKPOINT  
COMPND  87 KINASE MAD3L,PROTEIN SSK1,MAD3/BUB1-RELATED PROTEIN KINASE,HBUBR1,   
COMPND  88 MITOTIC CHECKPOINT KINASE MAD3L,PROTEIN SSK1;                        
COMPND  89 EC: 2.7.11.1,2.7.11.1;                                               
COMPND  90 ENGINEERED: YES;                                                     
COMPND  91 MOL_ID: 17;                                                          
COMPND  92 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 7;                      
COMPND  93 CHAIN: X, Y;                                                         
COMPND  94 SYNONYM: APC7,CYCLOSOME SUBUNIT 7;                                   
COMPND  95 ENGINEERED: YES;                                                     
COMPND  96 MOL_ID: 18;                                                          
COMPND  97 MOLECULE: MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A;         
COMPND  98 CHAIN: Z;                                                            
COMPND  99 SYNONYM: HSMAD2,MITOTIC ARREST DEFICIENT 2-LIKE PROTEIN 1,MAD2-LIKE  
COMPND 100 PROTEIN 1;                                                           
COMPND 101 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: ANAPC1, TSG24;                                                 
SOURCE   6 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE   7 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 GENE: ANAPC11, HSPC214;                                              
SOURCE  14 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  15 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  17 MOL_ID: 3;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 GENE: CDC23, ANAPC8;                                                 
SOURCE  22 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  23 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  24 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  25 MOL_ID: 4;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 GENE: ANAPC15, C11ORF51, HSPC020;                                    
SOURCE  30 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  31 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  32 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  33 MOL_ID: 5;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  35 ORGANISM_COMMON: HUMAN;                                              
SOURCE  36 ORGANISM_TAXID: 9606;                                                
SOURCE  37 GENE: ANAPC16, C10ORF104, CENP-27;                                   
SOURCE  38 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  39 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  40 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  41 MOL_ID: 6;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 GENE: CDC27, ANAPC3, D0S1430E, D17S978E;                             
SOURCE  46 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  47 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  48 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  49 MOL_ID: 7;                                                           
SOURCE  50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  51 ORGANISM_COMMON: HUMAN;                                              
SOURCE  52 ORGANISM_TAXID: 9606;                                                
SOURCE  53 GENE: CDC26, ANAPC12, C9ORF17;                                       
SOURCE  54 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  55 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  56 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  57 MOL_ID: 8;                                                           
SOURCE  58 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  59 ORGANISM_COMMON: HUMAN;                                              
SOURCE  60 ORGANISM_TAXID: 9606;                                                
SOURCE  61 GENE: ANAPC4, APC4;                                                  
SOURCE  62 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  63 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  64 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  65 MOL_ID: 9;                                                           
SOURCE  66 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  67 ORGANISM_COMMON: HUMAN;                                              
SOURCE  68 ORGANISM_TAXID: 9606;                                                
SOURCE  69 GENE: CDC16, ANAPC6;                                                 
SOURCE  70 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  71 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  72 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  73 MOL_ID: 10;                                                          
SOURCE  74 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  75 ORGANISM_COMMON: HUMAN;                                              
SOURCE  76 ORGANISM_TAXID: 9606;                                                
SOURCE  77 GENE: ANAPC10, APC10;                                                
SOURCE  78 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  79 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  80 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  81 MOL_ID: 11;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  83 ORGANISM_COMMON: HUMAN;                                              
SOURCE  84 ORGANISM_TAXID: 9606;                                                
SOURCE  85 GENE: ANAPC13;                                                       
SOURCE  86 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  87 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  88 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  89 MOL_ID: 12;                                                          
SOURCE  90 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  91 ORGANISM_COMMON: HUMAN;                                              
SOURCE  92 ORGANISM_TAXID: 9606;                                                
SOURCE  93 GENE: ANAPC2, APC2, KIAA1406;                                        
SOURCE  94 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  95 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  96 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  97 MOL_ID: 13;                                                          
SOURCE  98 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  99 ORGANISM_COMMON: HUMAN;                                              
SOURCE 100 ORGANISM_TAXID: 9606;                                                
SOURCE 101 GENE: ANAPC5, APC5;                                                  
SOURCE 102 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 103 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 104 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 105 MOL_ID: 14;                                                          
SOURCE 106 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 107 ORGANISM_COMMON: HUMAN;                                              
SOURCE 108 ORGANISM_TAXID: 9606;                                                
SOURCE 109 GENE: CDC20;                                                         
SOURCE 110 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 111 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 112 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 113 MOL_ID: 15;                                                          
SOURCE 114 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 115 ORGANISM_COMMON: HUMAN;                                              
SOURCE 116 ORGANISM_TAXID: 9606;                                                
SOURCE 117 GENE: CDC20;                                                         
SOURCE 118 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 119 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 120 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 121 MOL_ID: 16;                                                          
SOURCE 122 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 123 ORGANISM_COMMON: HUMAN;                                              
SOURCE 124 ORGANISM_TAXID: 9606;                                                
SOURCE 125 GENE: BUB1B, BUBR1, MAD3L, SSK1;                                     
SOURCE 126 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 127 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 128 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 129 MOL_ID: 17;                                                          
SOURCE 130 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 131 ORGANISM_COMMON: HUMAN;                                              
SOURCE 132 ORGANISM_TAXID: 9606;                                                
SOURCE 133 GENE: ANAPC7, APC7;                                                  
SOURCE 134 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 135 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 136 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 137 MOL_ID: 18;                                                          
SOURCE 138 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 139 ORGANISM_COMMON: HUMAN;                                              
SOURCE 140 ORGANISM_TAXID: 9606;                                                
SOURCE 141 GENE: MAD2L1, MAD2;                                                  
SOURCE 142 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 143 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 144 EXPRESSION_SYSTEM_TAXID: 7111                                        
KEYWDS    COMPLEX, UBIQUITIN, E3 LIGASE, UBIQUITIN LIGASE, CULLIN, RING, CELL   
KEYWDS   2 CYCLE, MITOSIS, SPINDLE CHECKPOINT, DEGRON                           
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    C.ALFIERI,L.CHANG,Z.ZHANG,J.YANG,S.MASLEN,M.SKEHEL,D.BARFORD          
REVDAT   6   24-OCT-18 5LCW    1       REMARK LINK                              
REVDAT   5   07-SEP-16 5LCW    1       JRNL                                     
REVDAT   4   31-AUG-16 5LCW    1       JRNL                                     
REVDAT   3   24-AUG-16 5LCW    1       JRNL                                     
REVDAT   2   17-AUG-16 5LCW    1                                                
REVDAT   1   10-AUG-16 5LCW    0                                                
JRNL        AUTH   C.ALFIERI,L.CHANG,Z.ZHANG,J.YANG,S.MASLEN,M.SKEHEL,D.BARFORD 
JRNL        TITL   MOLECULAR BASIS OF APC/C REGULATION BY THE SPINDLE ASSEMBLY  
JRNL        TITL 2 CHECKPOINT.                                                  
JRNL        REF    NATURE                        V. 536   431 2016              
JRNL        REFN                   ESSN 1476-4687                               
JRNL        PMID   27509861                                                     
JRNL        DOI    10.1038/NATURE19083                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION                                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.200                          
REMARK   3   NUMBER OF PARTICLES               : 155263                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5LCW COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 28-JUN-16.                  
REMARK 100 THE DEPOSITION ID IS D_1200000531.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : ANAPHASE-PROMOTING                
REMARK 245                                    COMPLEX/CYCLOSOME, IN COMPLEX     
REMARK 245                                    WITH THE MITOTIC CHECKPOINT       
REMARK 245                                    COMPLEX IN CLOSED CONFORMATION    
REMARK 245                                    (APC/C-MCC-CLOSED) AT 4.2         
REMARK 245                                    ANGSTROM RESOLUTION               
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI POLARA 300                 
REMARK 245   DETECTOR TYPE                     : FEI FALCON II (4K X 4K)        
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 27.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 23-MERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 120240 ANGSTROM**2                        
REMARK 350 SURFACE AREA OF THE COMPLEX: 368970 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -558.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N, O, P, Q, R, S,            
REMARK 350                    AND CHAINS: W, X, Y, Z                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     ASN A     3                                                      
REMARK 465     PHE A     4                                                      
REMARK 465     TYR A     5                                                      
REMARK 465     GLU A     6                                                      
REMARK 465     GLU A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     THR A    10                                                      
REMARK 465     GLY A    59                                                      
REMARK 465     SER A    60                                                      
REMARK 465     LEU A    61                                                      
REMARK 465     GLN A    62                                                      
REMARK 465     GLU A    63                                                      
REMARK 465     VAL A    64                                                      
REMARK 465     THR A    65                                                      
REMARK 465     ILE A    66                                                      
REMARK 465     HIS A    67                                                      
REMARK 465     GLU A    68                                                      
REMARK 465     LYS A    69                                                      
REMARK 465     GLN A    70                                                      
REMARK 465     GLN A   135                                                      
REMARK 465     ASP A   136                                                      
REMARK 465     LYS A   137                                                      
REMARK 465     SER A   138                                                      
REMARK 465     GLU A   139                                                      
REMARK 465     LYS A   140                                                      
REMARK 465     ALA A   141                                                      
REMARK 465     TYR A   142                                                      
REMARK 465     SER A   143                                                      
REMARK 465     SER A   144                                                      
REMARK 465     ASN A   145                                                      
REMARK 465     ALA A   193                                                      
REMARK 465     SER A   194                                                      
REMARK 465     SER A   195                                                      
REMARK 465     HIS A   196                                                      
REMARK 465     GLU A   197                                                      
REMARK 465     VAL A   198                                                      
REMARK 465     PRO A   199                                                      
REMARK 465     PRO A   200                                                      
REMARK 465     GLY A   201                                                      
REMARK 465     SER A   202                                                      
REMARK 465     PRO A   203                                                      
REMARK 465     ARG A   204                                                      
REMARK 465     GLU A   205                                                      
REMARK 465     SER A   227                                                      
REMARK 465     GLY A   228                                                      
REMARK 465     SER A   229                                                      
REMARK 465     LEU A   230                                                      
REMARK 465     PHE A   231                                                      
REMARK 465     GLY A   232                                                      
REMARK 465     SER A   233                                                      
REMARK 465     SER A   234                                                      
REMARK 465     ARG A   235                                                      
REMARK 465     VAL A   281                                                      
REMARK 465     VAL A   282                                                      
REMARK 465     LEU A   283                                                      
REMARK 465     LYS A   284                                                      
REMARK 465     PHE A   285                                                      
REMARK 465     SER A   286                                                      
REMARK 465     GLU A   287                                                      
REMARK 465     GLN A   288                                                      
REMARK 465     GLY A   289                                                      
REMARK 465     GLY A   290                                                      
REMARK 465     THR A   291                                                      
REMARK 465     PRO A   292                                                      
REMARK 465     GLN A   293                                                      
REMARK 465     ASN A   294                                                      
REMARK 465     VAL A   295                                                      
REMARK 465     ALA A   296                                                      
REMARK 465     THR A   297                                                      
REMARK 465     SER A   298                                                      
REMARK 465     SER A   299                                                      
REMARK 465     SER A   300                                                      
REMARK 465     LEU A   301                                                      
REMARK 465     THR A   302                                                      
REMARK 465     ALA A   303                                                      
REMARK 465     HIS A   304                                                      
REMARK 465     LEU A   305                                                      
REMARK 465     ARG A   306                                                      
REMARK 465     SER A   307                                                      
REMARK 465     LEU A   308                                                      
REMARK 465     SER A   309                                                      
REMARK 465     LYS A   310                                                      
REMARK 465     GLY A   311                                                      
REMARK 465     ASP A   312                                                      
REMARK 465     SER A   313                                                      
REMARK 465     PRO A   314                                                      
REMARK 465     VAL A   315                                                      
REMARK 465     THR A   316                                                      
REMARK 465     SER A   317                                                      
REMARK 465     PRO A   318                                                      
REMARK 465     PHE A   319                                                      
REMARK 465     GLN A   320                                                      
REMARK 465     ASN A   321                                                      
REMARK 465     TYR A   322                                                      
REMARK 465     SER A   323                                                      
REMARK 465     SER A   324                                                      
REMARK 465     ILE A   325                                                      
REMARK 465     HIS A   326                                                      
REMARK 465     SER A   327                                                      
REMARK 465     GLN A   328                                                      
REMARK 465     SER A   329                                                      
REMARK 465     ARG A   330                                                      
REMARK 465     SER A   331                                                      
REMARK 465     THR A   332                                                      
REMARK 465     SER A   333                                                      
REMARK 465     SER A   334                                                      
REMARK 465     PRO A   335                                                      
REMARK 465     SER A   336                                                      
REMARK 465     LEU A   337                                                      
REMARK 465     HIS A   338                                                      
REMARK 465     SER A   339                                                      
REMARK 465     ARG A   340                                                      
REMARK 465     SER A   341                                                      
REMARK 465     PRO A   342                                                      
REMARK 465     SER A   343                                                      
REMARK 465     ILE A   344                                                      
REMARK 465     SER A   345                                                      
REMARK 465     HIS A   361                                                      
REMARK 465     SER A   362                                                      
REMARK 465     PHE A   363                                                      
REMARK 465     SER A   364                                                      
REMARK 465     GLY A   365                                                      
REMARK 465     VAL A   366                                                      
REMARK 465     GLN A   367                                                      
REMARK 465     ARG A   368                                                      
REMARK 465     PHE A   369                                                      
REMARK 465     ASN A   370                                                      
REMARK 465     ILE A   371                                                      
REMARK 465     SER A   372                                                      
REMARK 465     SER A   373                                                      
REMARK 465     HIS A   374                                                      
REMARK 465     ASN A   375                                                      
REMARK 465     GLN A   376                                                      
REMARK 465     SER A   377                                                      
REMARK 465     PRO A   378                                                      
REMARK 465     LYS A   379                                                      
REMARK 465     ARG A   380                                                      
REMARK 465     HIS A   381                                                      
REMARK 465     SER A   382                                                      
REMARK 465     ILE A   383                                                      
REMARK 465     SER A   384                                                      
REMARK 465     HIS A   385                                                      
REMARK 465     SER A   386                                                      
REMARK 465     PRO A   387                                                      
REMARK 465     ASN A   388                                                      
REMARK 465     SER A   389                                                      
REMARK 465     ASN A   390                                                      
REMARK 465     SER A   391                                                      
REMARK 465     ASN A   392                                                      
REMARK 465     GLY A   393                                                      
REMARK 465     SER A   394                                                      
REMARK 465     PHE A   395                                                      
REMARK 465     LEU A   396                                                      
REMARK 465     ALA A   397                                                      
REMARK 465     PRO A   398                                                      
REMARK 465     GLU A   399                                                      
REMARK 465     THR A   400                                                      
REMARK 465     GLU A   401                                                      
REMARK 465     GLU A   415                                                      
REMARK 465     THR A   416                                                      
REMARK 465     ILE A   417                                                      
REMARK 465     THR A   418                                                      
REMARK 465     ASN A   419                                                      
REMARK 465     ILE A   420                                                      
REMARK 465     ARG A   421                                                      
REMARK 465     GLU A   422                                                      
REMARK 465     LYS A   423                                                      
REMARK 465     ASN A   461                                                      
REMARK 465     ASP A   462                                                      
REMARK 465     LYS A   463                                                      
REMARK 465     LEU A   514                                                      
REMARK 465     PRO A   515                                                      
REMARK 465     ALA A   516                                                      
REMARK 465     PRO A   517                                                      
REMARK 465     SER A   518                                                      
REMARK 465     LEU A   519                                                      
REMARK 465     THR A   520                                                      
REMARK 465     MET A   521                                                      
REMARK 465     SER A   522                                                      
REMARK 465     ASN A   523                                                      
REMARK 465     THR A   524                                                      
REMARK 465     MET A   525                                                      
REMARK 465     PRO A   526                                                      
REMARK 465     ARG A   527                                                      
REMARK 465     PRO A   528                                                      
REMARK 465     SER A   529                                                      
REMARK 465     THR A   530                                                      
REMARK 465     PRO A   531                                                      
REMARK 465     LEU A   532                                                      
REMARK 465     ASP A   533                                                      
REMARK 465     GLY A   534                                                      
REMARK 465     VAL A   535                                                      
REMARK 465     SER A   536                                                      
REMARK 465     THR A   537                                                      
REMARK 465     PRO A   538                                                      
REMARK 465     LYS A   539                                                      
REMARK 465     PRO A   540                                                      
REMARK 465     LEU A   541                                                      
REMARK 465     SER A   542                                                      
REMARK 465     LYS A   543                                                      
REMARK 465     LEU A   544                                                      
REMARK 465     LEU A   545                                                      
REMARK 465     GLY A   546                                                      
REMARK 465     SER A   547                                                      
REMARK 465     LEU A   548                                                      
REMARK 465     ASP A   549                                                      
REMARK 465     GLU A   550                                                      
REMARK 465     VAL A   551                                                      
REMARK 465     VAL A   552                                                      
REMARK 465     LEU A   553                                                      
REMARK 465     LEU A   554                                                      
REMARK 465     SER A   555                                                      
REMARK 465     PRO A   556                                                      
REMARK 465     VAL A   557                                                      
REMARK 465     PRO A   558                                                      
REMARK 465     GLU A   559                                                      
REMARK 465     LEU A   560                                                      
REMARK 465     ARG A   561                                                      
REMARK 465     ASP A   562                                                      
REMARK 465     SER A   563                                                      
REMARK 465     SER A   564                                                      
REMARK 465     LYS A   565                                                      
REMARK 465     LEU A   566                                                      
REMARK 465     HIS A   567                                                      
REMARK 465     ASP A   568                                                      
REMARK 465     SER A   569                                                      
REMARK 465     LEU A   570                                                      
REMARK 465     TYR A   571                                                      
REMARK 465     ASN A   572                                                      
REMARK 465     GLU A   573                                                      
REMARK 465     ASP A   574                                                      
REMARK 465     CYS A   575                                                      
REMARK 465     THR A   576                                                      
REMARK 465     PHE A   577                                                      
REMARK 465     GLN A   578                                                      
REMARK 465     GLN A   579                                                      
REMARK 465     LEU A   580                                                      
REMARK 465     GLY A   581                                                      
REMARK 465     ASN A   671                                                      
REMARK 465     THR A   672                                                      
REMARK 465     ASP A   673                                                      
REMARK 465     ARG A   674                                                      
REMARK 465     LEU A   675                                                      
REMARK 465     ALA A   676                                                      
REMARK 465     TRP A   677                                                      
REMARK 465     THR A   678                                                      
REMARK 465     ARG A   679                                                      
REMARK 465     ASN A   680                                                      
REMARK 465     PHE A   681                                                      
REMARK 465     ASP A   682                                                      
REMARK 465     PHE A   683                                                      
REMARK 465     GLU A   684                                                      
REMARK 465     GLY A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     LEU A   687                                                      
REMARK 465     SER A   688                                                      
REMARK 465     PRO A   689                                                      
REMARK 465     VAL A   690                                                      
REMARK 465     ILE A   691                                                      
REMARK 465     ALA A   692                                                      
REMARK 465     PRO A   693                                                      
REMARK 465     LYS A   694                                                      
REMARK 465     LYS A   695                                                      
REMARK 465     ALA A   696                                                      
REMARK 465     ARG A   697                                                      
REMARK 465     PRO A   698                                                      
REMARK 465     SER A   699                                                      
REMARK 465     GLU A   700                                                      
REMARK 465     THR A   701                                                      
REMARK 465     GLY A   702                                                      
REMARK 465     SER A   703                                                      
REMARK 465     ASP A   704                                                      
REMARK 465     ASP A   705                                                      
REMARK 465     ASP A   706                                                      
REMARK 465     TRP A   707                                                      
REMARK 465     GLU A   708                                                      
REMARK 465     TYR A   709                                                      
REMARK 465     LEU A   710                                                      
REMARK 465     LEU A   711                                                      
REMARK 465     ASN A   712                                                      
REMARK 465     SER A   713                                                      
REMARK 465     ASP A   714                                                      
REMARK 465     TYR A   715                                                      
REMARK 465     HIS A   716                                                      
REMARK 465     GLN A   717                                                      
REMARK 465     ASN A   718                                                      
REMARK 465     VAL A   719                                                      
REMARK 465     GLU A   720                                                      
REMARK 465     SER A   721                                                      
REMARK 465     HIS A   722                                                      
REMARK 465     LEU A   723                                                      
REMARK 465     LEU A   724                                                      
REMARK 465     ASN A   725                                                      
REMARK 465     ARG A   726                                                      
REMARK 465     SER A   727                                                      
REMARK 465     LEU A   728                                                      
REMARK 465     CYS A   729                                                      
REMARK 465     LEU A   730                                                      
REMARK 465     SER A   731                                                      
REMARK 465     PRO A   732                                                      
REMARK 465     SER A   733                                                      
REMARK 465     GLU A   734                                                      
REMARK 465     ALA A   735                                                      
REMARK 465     SER A   736                                                      
REMARK 465     GLN A   737                                                      
REMARK 465     MET A   738                                                      
REMARK 465     LYS A   739                                                      
REMARK 465     ASP A   740                                                      
REMARK 465     GLU A   741                                                      
REMARK 465     ASP A   742                                                      
REMARK 465     PHE A   743                                                      
REMARK 465     SER A   744                                                      
REMARK 465     GLN A   745                                                      
REMARK 465     ASN A   746                                                      
REMARK 465     LEU A   747                                                      
REMARK 465     SER A   748                                                      
REMARK 465     LEU A   749                                                      
REMARK 465     ASP A   750                                                      
REMARK 465     SER A   751                                                      
REMARK 465     SER A   752                                                      
REMARK 465     THR A   753                                                      
REMARK 465     LEU A   754                                                      
REMARK 465     LEU A   755                                                      
REMARK 465     PHE A   756                                                      
REMARK 465     ARG A   815                                                      
REMARK 465     THR A   816                                                      
REMARK 465     THR A   817                                                      
REMARK 465     GLY A   818                                                      
REMARK 465     GLN A   819                                                      
REMARK 465     VAL A   820                                                      
REMARK 465     CYS A   821                                                      
REMARK 465     THR A   822                                                      
REMARK 465     ILE A   823                                                      
REMARK 465     ASP A   824                                                      
REMARK 465     PRO A   825                                                      
REMARK 465     GLY A   826                                                      
REMARK 465     GLN A   827                                                      
REMARK 465     THR A   828                                                      
REMARK 465     GLY A   829                                                      
REMARK 465     PHE A   830                                                      
REMARK 465     MET A   831                                                      
REMARK 465     HIS A   832                                                      
REMARK 465     HIS A   833                                                      
REMARK 465     PRO A   834                                                      
REMARK 465     SER A   835                                                      
REMARK 465     PHE A   836                                                      
REMARK 465     PHE A   837                                                      
REMARK 465     THR A   838                                                      
REMARK 465     GLY A   883                                                      
REMARK 465     ASP A   884                                                      
REMARK 465     GLU A   885                                                      
REMARK 465     SER A   886                                                      
REMARK 465     LEU A   887                                                      
REMARK 465     VAL A   888                                                      
REMARK 465     SER A   889                                                      
REMARK 465     ASP A   890                                                      
REMARK 465     GLU A   891                                                      
REMARK 465     SER A   892                                                      
REMARK 465     SER A   893                                                      
REMARK 465     GLN A   894                                                      
REMARK 465     TYR A   895                                                      
REMARK 465     LEU A   896                                                      
REMARK 465     THR A   897                                                      
REMARK 465     ARG A   898                                                      
REMARK 465     ILE A   899                                                      
REMARK 465     THR A   900                                                      
REMARK 465     ILE A   901                                                      
REMARK 465     ALA A   902                                                      
REMARK 465     PRO A   903                                                      
REMARK 465     GLN A   904                                                      
REMARK 465     LYS A   905                                                      
REMARK 465     LEU A   906                                                      
REMARK 465     GLN A   907                                                      
REMARK 465     VAL A   908                                                      
REMARK 465     GLU A   909                                                      
REMARK 465     GLN A   910                                                      
REMARK 465     GLU A   911                                                      
REMARK 465     GLU A   912                                                      
REMARK 465     ASN A   913                                                      
REMARK 465     ARG A   914                                                      
REMARK 465     PHE A   915                                                      
REMARK 465     SER A   916                                                      
REMARK 465     PHE A   917                                                      
REMARK 465     ARG A   918                                                      
REMARK 465     HIS A   919                                                      
REMARK 465     SER A   920                                                      
REMARK 465     THR A   921                                                      
REMARK 465     SER A   922                                                      
REMARK 465     VAL A   923                                                      
REMARK 465     ALA A   987                                                      
REMARK 465     CYS A   988                                                      
REMARK 465     GLU A   989                                                      
REMARK 465     GLY A   990                                                      
REMARK 465     ASN A   991                                                      
REMARK 465     LEU A   992                                                      
REMARK 465     PRO A   993                                                      
REMARK 465     LYS A   994                                                      
REMARK 465     GLY A   995                                                      
REMARK 465     LYS A   996                                                      
REMARK 465     SER A   997                                                      
REMARK 465     VAL A   998                                                      
REMARK 465     LEU A   999                                                      
REMARK 465     SER A  1000                                                      
REMARK 465     SER A  1001                                                      
REMARK 465     ASP A  1002                                                      
REMARK 465     VAL A  1003                                                      
REMARK 465     PRO A  1004                                                      
REMARK 465     SER A  1005                                                      
REMARK 465     GLY A  1006                                                      
REMARK 465     THR A  1007                                                      
REMARK 465     GLU A  1008                                                      
REMARK 465     THR A  1009                                                      
REMARK 465     GLU A  1010                                                      
REMARK 465     GLU A  1011                                                      
REMARK 465     GLU A  1012                                                      
REMARK 465     ARG A  1334                                                      
REMARK 465     ARG A  1335                                                      
REMARK 465     PHE A  1336                                                      
REMARK 465     GLN A  1337                                                      
REMARK 465     THR A  1338                                                      
REMARK 465     GLY A  1339                                                      
REMARK 465     MET A  1340                                                      
REMARK 465     HIS A  1341                                                      
REMARK 465     ARG A  1342                                                      
REMARK 465     GLU A  1343                                                      
REMARK 465     LYS A  1344                                                      
REMARK 465     HIS A  1345                                                      
REMARK 465     LYS A  1346                                                      
REMARK 465     SER A  1438                                                      
REMARK 465     ILE A  1439                                                      
REMARK 465     SER A  1440                                                      
REMARK 465     LEU A  1441                                                      
REMARK 465     SER A  1442                                                      
REMARK 465     GLU A  1443                                                      
REMARK 465     ILE A  1444                                                      
REMARK 465     GLU A  1445                                                      
REMARK 465     LEU A  1446                                                      
REMARK 465     PRO A  1447                                                      
REMARK 465     CYS A  1448                                                      
REMARK 465     SER A  1449                                                      
REMARK 465     GLU A  1450                                                      
REMARK 465     ASP A  1451                                                      
REMARK 465     SER A  1681                                                      
REMARK 465     LYS A  1682                                                      
REMARK 465     GLY A  1683                                                      
REMARK 465     PRO A  1712                                                      
REMARK 465     MET A  1713                                                      
REMARK 465     GLY A  1714                                                      
REMARK 465     TRP A  1715                                                      
REMARK 465     GLN A  1716                                                      
REMARK 465     SER A  1717                                                      
REMARK 465     LEU A  1718                                                      
REMARK 465     LEU A  1719                                                      
REMARK 465     ALA A  1720                                                      
REMARK 465     GLN A  1721                                                      
REMARK 465     THR A  1722                                                      
REMARK 465     VAL A  1723                                                      
REMARK 465     ALA A  1724                                                      
REMARK 465     ASN A  1725                                                      
REMARK 465     ARG A  1726                                                      
REMARK 465     PRO A  1735                                                      
REMARK 465     GLU A  1736                                                      
REMARK 465     THR A  1737                                                      
REMARK 465     ILE A  1738                                                      
REMARK 465     GLU A  1828                                                      
REMARK 465     ARG A  1829                                                      
REMARK 465     LEU A  1830                                                      
REMARK 465     GLN A  1831                                                      
REMARK 465     ASN A  1832                                                      
REMARK 465     HIS A  1833                                                      
REMARK 465     PRO A  1834                                                      
REMARK 465     LYS A  1835                                                      
REMARK 465     ARG A  1836                                                      
REMARK 465     GLY A  1837                                                      
REMARK 465     LEU A  1838                                                      
REMARK 465     GLY A  1874                                                      
REMARK 465     GLN A  1875                                                      
REMARK 465     PRO A  1876                                                      
REMARK 465     GLN A  1898                                                      
REMARK 465     HIS A  1899                                                      
REMARK 465     LEU A  1900                                                      
REMARK 465     PRO A  1901                                                      
REMARK 465     PRO A  1902                                                      
REMARK 465     ILE A  1903                                                      
REMARK 465     GLY A  1904                                                      
REMARK 465     LEU A  1905                                                      
REMARK 465     GLU A  1906                                                      
REMARK 465     GLY A  1907                                                      
REMARK 465     SER A  1908                                                      
REMARK 465     THR A  1909                                                      
REMARK 465     SER A  1910                                                      
REMARK 465     PHE A  1911                                                      
REMARK 465     GLY A  1937                                                      
REMARK 465     ASN A  1938                                                      
REMARK 465     PRO A  1939                                                      
REMARK 465     GLN A  1940                                                      
REMARK 465     PRO A  1941                                                      
REMARK 465     MET A  1942                                                      
REMARK 465     VAL A  1943                                                      
REMARK 465     MET A  1944                                                      
REMARK 465     ALA B    18                                                      
REMARK 465     ASN B    19                                                      
REMARK 465     ASP B    20                                                      
REMARK 465     GLU B    21                                                      
REMARK 465     ASN B    22                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     THR C     5                                                      
REMARK 465     SER C     6                                                      
REMARK 465     MET C     7                                                      
REMARK 465     VAL C     8                                                      
REMARK 465     PRO C     9                                                      
REMARK 465     VAL C    10                                                      
REMARK 465     ALA C    11                                                      
REMARK 465     VAL C    12                                                      
REMARK 465     THR C    13                                                      
REMARK 465     ALA C    14                                                      
REMARK 465     ALA C    15                                                      
REMARK 465     VAL C    16                                                      
REMARK 465     ALA C    17                                                      
REMARK 465     PRO C    18                                                      
REMARK 465     VAL C    19                                                      
REMARK 465     LEU C    20                                                      
REMARK 465     SER C    21                                                      
REMARK 465     ILE C    22                                                      
REMARK 465     ASN C    23                                                      
REMARK 465     SER C    24                                                      
REMARK 465     ASP C    25                                                      
REMARK 465     GLY C   501                                                      
REMARK 465     GLU C   502                                                      
REMARK 465     ILE C   503                                                      
REMARK 465     VAL C   504                                                      
REMARK 465     GLU C   505                                                      
REMARK 465     HIS C   506                                                      
REMARK 465     LEU C   507                                                      
REMARK 465     GLU C   508                                                      
REMARK 465     ASN C   558                                                      
REMARK 465     GLN C   559                                                      
REMARK 465     GLY C   560                                                      
REMARK 465     GLU C   561                                                      
REMARK 465     THR C   562                                                      
REMARK 465     PRO C   563                                                      
REMARK 465     THR C   564                                                      
REMARK 465     THR C   565                                                      
REMARK 465     GLU C   566                                                      
REMARK 465     VAL C   567                                                      
REMARK 465     PRO C   568                                                      
REMARK 465     ALA C   569                                                      
REMARK 465     PRO C   570                                                      
REMARK 465     PHE C   571                                                      
REMARK 465     PHE C   572                                                      
REMARK 465     LEU C   573                                                      
REMARK 465     PRO C   574                                                      
REMARK 465     ALA C   575                                                      
REMARK 465     SER C   576                                                      
REMARK 465     LEU C   577                                                      
REMARK 465     SER C   578                                                      
REMARK 465     ALA C   579                                                      
REMARK 465     ASN C   580                                                      
REMARK 465     ASN C   581                                                      
REMARK 465     THR C   582                                                      
REMARK 465     PRO C   583                                                      
REMARK 465     THR C   584                                                      
REMARK 465     ARG C   585                                                      
REMARK 465     ARG C   586                                                      
REMARK 465     VAL C   587                                                      
REMARK 465     SER C   588                                                      
REMARK 465     PRO C   589                                                      
REMARK 465     LEU C   590                                                      
REMARK 465     ASN C   591                                                      
REMARK 465     LEU C   592                                                      
REMARK 465     SER C   593                                                      
REMARK 465     SER C   594                                                      
REMARK 465     VAL C   595                                                      
REMARK 465     THR C   596                                                      
REMARK 465     PRO C   597                                                      
REMARK 465     MET D     1                                                      
REMARK 465     LEU D    20                                                      
REMARK 465     ASP D    21                                                      
REMARK 465     ARG D    22                                                      
REMARK 465     PRO D    23                                                      
REMARK 465     CYS D    24                                                      
REMARK 465     VAL D    25                                                      
REMARK 465     GLU D    26                                                      
REMARK 465     GLU D    27                                                      
REMARK 465     THR D    28                                                      
REMARK 465     GLU D    29                                                      
REMARK 465     LEU D    30                                                      
REMARK 465     GLN D    31                                                      
REMARK 465     GLN D    32                                                      
REMARK 465     GLN D    33                                                      
REMARK 465     GLU D    34                                                      
REMARK 465     GLN D    35                                                      
REMARK 465     GLN D    36                                                      
REMARK 465     HIS D    37                                                      
REMARK 465     GLN D    38                                                      
REMARK 465     ALA D    39                                                      
REMARK 465     TRP D    40                                                      
REMARK 465     LEU D    41                                                      
REMARK 465     GLN D    42                                                      
REMARK 465     SER D    43                                                      
REMARK 465     ILE D    44                                                      
REMARK 465     ALA D    45                                                      
REMARK 465     GLU D    46                                                      
REMARK 465     LYS D    47                                                      
REMARK 465     ASP D    48                                                      
REMARK 465     ASN D    49                                                      
REMARK 465     ASN D    50                                                      
REMARK 465     LEU D    51                                                      
REMARK 465     VAL D    52                                                      
REMARK 465     PRO D    53                                                      
REMARK 465     ILE D    54                                                      
REMARK 465     GLY D    55                                                      
REMARK 465     LYS D    56                                                      
REMARK 465     PRO D    57                                                      
REMARK 465     ALA D    58                                                      
REMARK 465     SER D    59                                                      
REMARK 465     GLU D    60                                                      
REMARK 465     HIS D    61                                                      
REMARK 465     TYR D    62                                                      
REMARK 465     ASP D    63                                                      
REMARK 465     ASP D    64                                                      
REMARK 465     GLU D    65                                                      
REMARK 465     GLU D    66                                                      
REMARK 465     GLU D    67                                                      
REMARK 465     GLU D    68                                                      
REMARK 465     ASP D    69                                                      
REMARK 465     ASP D    70                                                      
REMARK 465     GLU D    71                                                      
REMARK 465     ASP D    72                                                      
REMARK 465     ASP D    73                                                      
REMARK 465     GLU D    74                                                      
REMARK 465     ASP D    75                                                      
REMARK 465     SER D    76                                                      
REMARK 465     GLU D    77                                                      
REMARK 465     GLU D    78                                                      
REMARK 465     ASP D    79                                                      
REMARK 465     SER D    80                                                      
REMARK 465     GLU D    81                                                      
REMARK 465     ASP D    82                                                      
REMARK 465     ASP D    83                                                      
REMARK 465     GLU D    84                                                      
REMARK 465     ASP D    85                                                      
REMARK 465     MET D    86                                                      
REMARK 465     GLN D    87                                                      
REMARK 465     ASP D    88                                                      
REMARK 465     MET D    89                                                      
REMARK 465     ASP D    90                                                      
REMARK 465     GLU D    91                                                      
REMARK 465     MET D    92                                                      
REMARK 465     ASN D    93                                                      
REMARK 465     ASP D    94                                                      
REMARK 465     TYR D    95                                                      
REMARK 465     ASN D    96                                                      
REMARK 465     GLU D    97                                                      
REMARK 465     SER D    98                                                      
REMARK 465     PRO D    99                                                      
REMARK 465     ASP D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     GLY D   102                                                      
REMARK 465     GLU D   103                                                      
REMARK 465     VAL D   104                                                      
REMARK 465     ASN D   105                                                      
REMARK 465     GLU D   106                                                      
REMARK 465     VAL D   107                                                      
REMARK 465     ASP D   108                                                      
REMARK 465     MET D   109                                                      
REMARK 465     GLU D   110                                                      
REMARK 465     GLY D   111                                                      
REMARK 465     ASN D   112                                                      
REMARK 465     GLU D   113                                                      
REMARK 465     GLN D   114                                                      
REMARK 465     ASP D   115                                                      
REMARK 465     GLN D   116                                                      
REMARK 465     ASP D   117                                                      
REMARK 465     GLN D   118                                                      
REMARK 465     TRP D   119                                                      
REMARK 465     MET D   120                                                      
REMARK 465     ILE D   121                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     SER E     4                                                      
REMARK 465     SER E     5                                                      
REMARK 465     SER E     6                                                      
REMARK 465     SER E     7                                                      
REMARK 465     SER E     8                                                      
REMARK 465     SER E     9                                                      
REMARK 465     ALA E    10                                                      
REMARK 465     GLY E    11                                                      
REMARK 465     GLY E    12                                                      
REMARK 465     VAL E    13                                                      
REMARK 465     SER E    14                                                      
REMARK 465     GLY E    15                                                      
REMARK 465     SER E    16                                                      
REMARK 465     SER E    17                                                      
REMARK 465     VAL E    18                                                      
REMARK 465     THR E    19                                                      
REMARK 465     GLY E    20                                                      
REMARK 465     SER E    21                                                      
REMARK 465     GLY E    22                                                      
REMARK 465     PHE E    23                                                      
REMARK 465     SER E    24                                                      
REMARK 465     VAL E    25                                                      
REMARK 465     SER E    26                                                      
REMARK 465     ASP E    27                                                      
REMARK 465     LEU E    28                                                      
REMARK 465     ALA E    29                                                      
REMARK 465     PRO E    30                                                      
REMARK 465     PRO E    31                                                      
REMARK 465     ARG E    32                                                      
REMARK 465     LYS E    33                                                      
REMARK 465     ALA E    34                                                      
REMARK 465     LEU E    35                                                      
REMARK 465     PHE E    36                                                      
REMARK 465     THR E    37                                                      
REMARK 465     TYR E    38                                                      
REMARK 465     PRO E    39                                                      
REMARK 465     LYS E    40                                                      
REMARK 465     GLY E    41                                                      
REMARK 465     ALA E    42                                                      
REMARK 465     GLY E    43                                                      
REMARK 465     GLU E    44                                                      
REMARK 465     MET E    45                                                      
REMARK 465     LEU E    46                                                      
REMARK 465     GLU E    47                                                      
REMARK 465     ASP E    48                                                      
REMARK 465     GLY E    49                                                      
REMARK 465     SER E    50                                                      
REMARK 465     GLU E    51                                                      
REMARK 465     SER E   108                                                      
REMARK 465     SER E   109                                                      
REMARK 465     GLY E   110                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     VAL F     3                                                      
REMARK 465     LEU F     4                                                      
REMARK 465     THR F   171                                                      
REMARK 465     SER F   172                                                      
REMARK 465     LEU F   173                                                      
REMARK 465     GLN F   174                                                      
REMARK 465     ASN F   175                                                      
REMARK 465     PHE F   176                                                      
REMARK 465     SER F   177                                                      
REMARK 465     ASN F   178                                                      
REMARK 465     CYS F   179                                                      
REMARK 465     LEU F   180                                                      
REMARK 465     PRO F   181                                                      
REMARK 465     ASN F   182                                                      
REMARK 465     SER F   183                                                      
REMARK 465     CYS F   184                                                      
REMARK 465     THR F   185                                                      
REMARK 465     THR F   186                                                      
REMARK 465     GLN F   187                                                      
REMARK 465     VAL F   188                                                      
REMARK 465     PRO F   189                                                      
REMARK 465     ASN F   190                                                      
REMARK 465     HIS F   191                                                      
REMARK 465     SER F   192                                                      
REMARK 465     LEU F   193                                                      
REMARK 465     SER F   194                                                      
REMARK 465     HIS F   195                                                      
REMARK 465     ARG F   196                                                      
REMARK 465     GLN F   197                                                      
REMARK 465     PRO F   198                                                      
REMARK 465     GLU F   199                                                      
REMARK 465     THR F   200                                                      
REMARK 465     VAL F   201                                                      
REMARK 465     LEU F   202                                                      
REMARK 465     THR F   203                                                      
REMARK 465     GLU F   204                                                      
REMARK 465     THR F   205                                                      
REMARK 465     PRO F   206                                                      
REMARK 465     GLN F   207                                                      
REMARK 465     ASP F   208                                                      
REMARK 465     THR F   209                                                      
REMARK 465     ILE F   210                                                      
REMARK 465     GLU F   211                                                      
REMARK 465     LEU F   212                                                      
REMARK 465     ASN F   213                                                      
REMARK 465     ARG F   214                                                      
REMARK 465     LEU F   215                                                      
REMARK 465     ASN F   216                                                      
REMARK 465     LEU F   217                                                      
REMARK 465     GLU F   218                                                      
REMARK 465     SER F   219                                                      
REMARK 465     SER F   220                                                      
REMARK 465     ASN F   221                                                      
REMARK 465     SER F   222                                                      
REMARK 465     LYS F   223                                                      
REMARK 465     TYR F   224                                                      
REMARK 465     SER F   225                                                      
REMARK 465     LEU F   226                                                      
REMARK 465     ASN F   227                                                      
REMARK 465     THR F   228                                                      
REMARK 465     ASP F   229                                                      
REMARK 465     SER F   230                                                      
REMARK 465     SER F   231                                                      
REMARK 465     VAL F   232                                                      
REMARK 465     SER F   233                                                      
REMARK 465     TYR F   234                                                      
REMARK 465     ILE F   235                                                      
REMARK 465     ASP F   236                                                      
REMARK 465     SER F   237                                                      
REMARK 465     ALA F   238                                                      
REMARK 465     VAL F   239                                                      
REMARK 465     ILE F   240                                                      
REMARK 465     SER F   241                                                      
REMARK 465     PRO F   242                                                      
REMARK 465     ASP F   243                                                      
REMARK 465     THR F   244                                                      
REMARK 465     VAL F   245                                                      
REMARK 465     PRO F   246                                                      
REMARK 465     LEU F   247                                                      
REMARK 465     GLY F   248                                                      
REMARK 465     THR F   249                                                      
REMARK 465     GLY F   250                                                      
REMARK 465     THR F   251                                                      
REMARK 465     SER F   252                                                      
REMARK 465     ILE F   253                                                      
REMARK 465     LEU F   254                                                      
REMARK 465     SER F   255                                                      
REMARK 465     LYS F   256                                                      
REMARK 465     GLN F   257                                                      
REMARK 465     VAL F   258                                                      
REMARK 465     GLN F   259                                                      
REMARK 465     ASN F   260                                                      
REMARK 465     LYS F   261                                                      
REMARK 465     PRO F   262                                                      
REMARK 465     LYS F   263                                                      
REMARK 465     THR F   264                                                      
REMARK 465     GLY F   265                                                      
REMARK 465     ARG F   266                                                      
REMARK 465     SER F   267                                                      
REMARK 465     LEU F   268                                                      
REMARK 465     LEU F   269                                                      
REMARK 465     GLY F   270                                                      
REMARK 465     GLY F   271                                                      
REMARK 465     PRO F   272                                                      
REMARK 465     ALA F   273                                                      
REMARK 465     ALA F   274                                                      
REMARK 465     LEU F   275                                                      
REMARK 465     SER F   276                                                      
REMARK 465     PRO F   277                                                      
REMARK 465     LEU F   278                                                      
REMARK 465     THR F   279                                                      
REMARK 465     PRO F   280                                                      
REMARK 465     SER F   281                                                      
REMARK 465     PHE F   282                                                      
REMARK 465     GLY F   283                                                      
REMARK 465     ILE F   284                                                      
REMARK 465     LEU F   285                                                      
REMARK 465     PRO F   286                                                      
REMARK 465     LEU F   287                                                      
REMARK 465     GLU F   288                                                      
REMARK 465     THR F   289                                                      
REMARK 465     PRO F   290                                                      
REMARK 465     SER F   291                                                      
REMARK 465     PRO F   292                                                      
REMARK 465     GLY F   293                                                      
REMARK 465     ASP F   294                                                      
REMARK 465     GLY F   295                                                      
REMARK 465     SER F   296                                                      
REMARK 465     TYR F   297                                                      
REMARK 465     LEU F   298                                                      
REMARK 465     GLN F   299                                                      
REMARK 465     ASN F   300                                                      
REMARK 465     TYR F   301                                                      
REMARK 465     THR F   302                                                      
REMARK 465     ASN F   303                                                      
REMARK 465     THR F   304                                                      
REMARK 465     PRO F   305                                                      
REMARK 465     PRO F   306                                                      
REMARK 465     VAL F   307                                                      
REMARK 465     ILE F   308                                                      
REMARK 465     ASP F   309                                                      
REMARK 465     VAL F   310                                                      
REMARK 465     PRO F   311                                                      
REMARK 465     SER F   312                                                      
REMARK 465     THR F   313                                                      
REMARK 465     GLY F   314                                                      
REMARK 465     ALA F   315                                                      
REMARK 465     PRO F   316                                                      
REMARK 465     SER F   317                                                      
REMARK 465     LYS F   318                                                      
REMARK 465     LYS F   319                                                      
REMARK 465     SER F   320                                                      
REMARK 465     VAL F   321                                                      
REMARK 465     ALA F   322                                                      
REMARK 465     ARG F   323                                                      
REMARK 465     ILE F   324                                                      
REMARK 465     GLY F   325                                                      
REMARK 465     GLN F   326                                                      
REMARK 465     THR F   327                                                      
REMARK 465     GLY F   328                                                      
REMARK 465     THR F   329                                                      
REMARK 465     LYS F   330                                                      
REMARK 465     SER F   331                                                      
REMARK 465     VAL F   332                                                      
REMARK 465     PHE F   333                                                      
REMARK 465     SER F   334                                                      
REMARK 465     GLN F   335                                                      
REMARK 465     SER F   336                                                      
REMARK 465     GLY F   337                                                      
REMARK 465     ASN F   338                                                      
REMARK 465     SER F   339                                                      
REMARK 465     ARG F   340                                                      
REMARK 465     GLU F   341                                                      
REMARK 465     VAL F   342                                                      
REMARK 465     THR F   343                                                      
REMARK 465     PRO F   344                                                      
REMARK 465     ILE F   345                                                      
REMARK 465     LEU F   346                                                      
REMARK 465     ALA F   347                                                      
REMARK 465     GLN F   348                                                      
REMARK 465     THR F   349                                                      
REMARK 465     GLN F   350                                                      
REMARK 465     SER F   351                                                      
REMARK 465     SER F   352                                                      
REMARK 465     GLY F   353                                                      
REMARK 465     PRO F   354                                                      
REMARK 465     GLN F   355                                                      
REMARK 465     THR F   356                                                      
REMARK 465     SER F   357                                                      
REMARK 465     THR F   358                                                      
REMARK 465     THR F   359                                                      
REMARK 465     PRO F   360                                                      
REMARK 465     GLN F   361                                                      
REMARK 465     VAL F   362                                                      
REMARK 465     LEU F   363                                                      
REMARK 465     SER F   364                                                      
REMARK 465     PRO F   365                                                      
REMARK 465     THR F   366                                                      
REMARK 465     ILE F   367                                                      
REMARK 465     THR F   368                                                      
REMARK 465     SER F   369                                                      
REMARK 465     PRO F   370                                                      
REMARK 465     PRO F   371                                                      
REMARK 465     ASN F   372                                                      
REMARK 465     ALA F   373                                                      
REMARK 465     LEU F   374                                                      
REMARK 465     PRO F   375                                                      
REMARK 465     ARG F   376                                                      
REMARK 465     ARG F   377                                                      
REMARK 465     SER F   378                                                      
REMARK 465     SER F   379                                                      
REMARK 465     ARG F   380                                                      
REMARK 465     LEU F   381                                                      
REMARK 465     PHE F   382                                                      
REMARK 465     THR F   383                                                      
REMARK 465     SER F   384                                                      
REMARK 465     ASP F   385                                                      
REMARK 465     SER F   386                                                      
REMARK 465     SER F   387                                                      
REMARK 465     THR F   388                                                      
REMARK 465     THR F   389                                                      
REMARK 465     LYS F   390                                                      
REMARK 465     GLU F   391                                                      
REMARK 465     ASN F   392                                                      
REMARK 465     SER F   393                                                      
REMARK 465     LYS F   394                                                      
REMARK 465     LYS F   395                                                      
REMARK 465     LEU F   396                                                      
REMARK 465     LYS F   397                                                      
REMARK 465     MET F   398                                                      
REMARK 465     LYS F   399                                                      
REMARK 465     PHE F   400                                                      
REMARK 465     PRO F   401                                                      
REMARK 465     PRO F   402                                                      
REMARK 465     LYS F   403                                                      
REMARK 465     ILE F   404                                                      
REMARK 465     PRO F   405                                                      
REMARK 465     ASN F   406                                                      
REMARK 465     ARG F   407                                                      
REMARK 465     LYS F   408                                                      
REMARK 465     THR F   409                                                      
REMARK 465     LYS F   410                                                      
REMARK 465     SER F   411                                                      
REMARK 465     LYS F   412                                                      
REMARK 465     THR F   413                                                      
REMARK 465     ASN F   414                                                      
REMARK 465     LYS F   415                                                      
REMARK 465     GLY F   416                                                      
REMARK 465     GLY F   417                                                      
REMARK 465     ILE F   418                                                      
REMARK 465     THR F   419                                                      
REMARK 465     GLN F   420                                                      
REMARK 465     PRO F   421                                                      
REMARK 465     ASN F   422                                                      
REMARK 465     ILE F   423                                                      
REMARK 465     ASN F   424                                                      
REMARK 465     ASP F   425                                                      
REMARK 465     SER F   426                                                      
REMARK 465     LEU F   427                                                      
REMARK 465     GLU F   428                                                      
REMARK 465     ILE F   429                                                      
REMARK 465     THR F   430                                                      
REMARK 465     LYS F   431                                                      
REMARK 465     LEU F   432                                                      
REMARK 465     ASP F   433                                                      
REMARK 465     SER F   434                                                      
REMARK 465     SER F   435                                                      
REMARK 465     ILE F   436                                                      
REMARK 465     ILE F   437                                                      
REMARK 465     SER F   438                                                      
REMARK 465     GLU F   439                                                      
REMARK 465     GLY F   440                                                      
REMARK 465     LYS F   441                                                      
REMARK 465     ILE F   442                                                      
REMARK 465     SER F   443                                                      
REMARK 465     THR F   444                                                      
REMARK 465     ILE F   445                                                      
REMARK 465     THR F   446                                                      
REMARK 465     PRO F   447                                                      
REMARK 465     GLN F   448                                                      
REMARK 465     ILE F   449                                                      
REMARK 465     GLN F   450                                                      
REMARK 465     PRO F   768                                                      
REMARK 465     LYS F   769                                                      
REMARK 465     GLY F   770                                                      
REMARK 465     ALA F   771                                                      
REMARK 465     ASN F   772                                                      
REMARK 465     ASN F   773                                                      
REMARK 465     GLN F   774                                                      
REMARK 465     ILE F   775                                                      
REMARK 465     LYS F   776                                                      
REMARK 465     GLU F   777                                                      
REMARK 465     ALA F   778                                                      
REMARK 465     ILE F   779                                                      
REMARK 465     ASP F   780                                                      
REMARK 465     LYS F   781                                                      
REMARK 465     ARG F   782                                                      
REMARK 465     TYR F   783                                                      
REMARK 465     LEU F   784                                                      
REMARK 465     PRO F   785                                                      
REMARK 465     ASP F   786                                                      
REMARK 465     ASP F   787                                                      
REMARK 465     GLU F   788                                                      
REMARK 465     GLU F   789                                                      
REMARK 465     PRO F   790                                                      
REMARK 465     ILE F   791                                                      
REMARK 465     THR F   792                                                      
REMARK 465     GLN F   793                                                      
REMARK 465     GLU F   794                                                      
REMARK 465     GLU F   795                                                      
REMARK 465     GLN F   796                                                      
REMARK 465     ILE F   797                                                      
REMARK 465     MET F   798                                                      
REMARK 465     GLY F   799                                                      
REMARK 465     THR F   800                                                      
REMARK 465     ASP F   801                                                      
REMARK 465     GLU F   802                                                      
REMARK 465     SER F   803                                                      
REMARK 465     GLN F   804                                                      
REMARK 465     GLU F   805                                                      
REMARK 465     SER F   806                                                      
REMARK 465     SER F   807                                                      
REMARK 465     MET F   808                                                      
REMARK 465     THR F   809                                                      
REMARK 465     ASP F   810                                                      
REMARK 465     ALA F   811                                                      
REMARK 465     ASP F   812                                                      
REMARK 465     ASP F   813                                                      
REMARK 465     THR F   814                                                      
REMARK 465     GLN F   815                                                      
REMARK 465     LEU F   816                                                      
REMARK 465     HIS F   817                                                      
REMARK 465     ALA F   818                                                      
REMARK 465     ALA F   819                                                      
REMARK 465     GLU F   820                                                      
REMARK 465     SER F   821                                                      
REMARK 465     ASP F   822                                                      
REMARK 465     GLU F   823                                                      
REMARK 465     PHE F   824                                                      
REMARK 465     LEU G    26                                                      
REMARK 465     GLU G    27                                                      
REMARK 465     THR G    28                                                      
REMARK 465     ARG G    29                                                      
REMARK 465     LYS G    30                                                      
REMARK 465     LYS G    31                                                      
REMARK 465     GLN G    32                                                      
REMARK 465     LYS G    33                                                      
REMARK 465     GLU G    34                                                      
REMARK 465     ASP G    35                                                      
REMARK 465     VAL G    36                                                      
REMARK 465     GLU G    37                                                      
REMARK 465     VAL G    38                                                      
REMARK 465     VAL G    39                                                      
REMARK 465     GLY G    40                                                      
REMARK 465     GLY G    41                                                      
REMARK 465     SER G    42                                                      
REMARK 465     ASP G    43                                                      
REMARK 465     GLY G    44                                                      
REMARK 465     GLU G    45                                                      
REMARK 465     GLY G    46                                                      
REMARK 465     ALA G    47                                                      
REMARK 465     ILE G    48                                                      
REMARK 465     GLY G    49                                                      
REMARK 465     LEU G    50                                                      
REMARK 465     SER G    51                                                      
REMARK 465     SER G    52                                                      
REMARK 465     ASP G    53                                                      
REMARK 465     PRO G    54                                                      
REMARK 465     LYS G    55                                                      
REMARK 465     SER G    56                                                      
REMARK 465     ARG G    57                                                      
REMARK 465     GLU G    58                                                      
REMARK 465     GLN G    59                                                      
REMARK 465     MET G    60                                                      
REMARK 465     ILE G    61                                                      
REMARK 465     ASN G    62                                                      
REMARK 465     ASP G    63                                                      
REMARK 465     ARG G    64                                                      
REMARK 465     ILE G    65                                                      
REMARK 465     GLY G    66                                                      
REMARK 465     TYR G    67                                                      
REMARK 465     LYS G    68                                                      
REMARK 465     PRO G    69                                                      
REMARK 465     GLN G    70                                                      
REMARK 465     PRO G    71                                                      
REMARK 465     LYS G    72                                                      
REMARK 465     PRO G    73                                                      
REMARK 465     ASN G    74                                                      
REMARK 465     ASN G    75                                                      
REMARK 465     ARG G    76                                                      
REMARK 465     SER G    77                                                      
REMARK 465     SER G    78                                                      
REMARK 465     GLN G    79                                                      
REMARK 465     PHE G    80                                                      
REMARK 465     GLY G    81                                                      
REMARK 465     SER G    82                                                      
REMARK 465     LEU G    83                                                      
REMARK 465     GLU G    84                                                      
REMARK 465     PHE G    85                                                      
REMARK 465     MET H     1                                                      
REMARK 465     THR H     2                                                      
REMARK 465     VAL H     3                                                      
REMARK 465     LEU H     4                                                      
REMARK 465     THR H   171                                                      
REMARK 465     SER H   172                                                      
REMARK 465     LEU H   173                                                      
REMARK 465     GLN H   174                                                      
REMARK 465     ASN H   175                                                      
REMARK 465     PHE H   176                                                      
REMARK 465     SER H   177                                                      
REMARK 465     ASN H   178                                                      
REMARK 465     CYS H   179                                                      
REMARK 465     LEU H   180                                                      
REMARK 465     PRO H   181                                                      
REMARK 465     ASN H   182                                                      
REMARK 465     SER H   183                                                      
REMARK 465     CYS H   184                                                      
REMARK 465     THR H   185                                                      
REMARK 465     THR H   186                                                      
REMARK 465     GLN H   187                                                      
REMARK 465     VAL H   188                                                      
REMARK 465     PRO H   189                                                      
REMARK 465     ASN H   190                                                      
REMARK 465     HIS H   191                                                      
REMARK 465     SER H   192                                                      
REMARK 465     LEU H   193                                                      
REMARK 465     SER H   194                                                      
REMARK 465     HIS H   195                                                      
REMARK 465     ARG H   196                                                      
REMARK 465     GLN H   197                                                      
REMARK 465     PRO H   198                                                      
REMARK 465     GLU H   199                                                      
REMARK 465     THR H   200                                                      
REMARK 465     VAL H   201                                                      
REMARK 465     LEU H   202                                                      
REMARK 465     THR H   203                                                      
REMARK 465     GLU H   204                                                      
REMARK 465     THR H   205                                                      
REMARK 465     PRO H   206                                                      
REMARK 465     GLN H   207                                                      
REMARK 465     ASP H   208                                                      
REMARK 465     THR H   209                                                      
REMARK 465     ILE H   210                                                      
REMARK 465     GLU H   211                                                      
REMARK 465     LEU H   212                                                      
REMARK 465     ASN H   213                                                      
REMARK 465     ARG H   214                                                      
REMARK 465     LEU H   215                                                      
REMARK 465     ASN H   216                                                      
REMARK 465     LEU H   217                                                      
REMARK 465     GLU H   218                                                      
REMARK 465     SER H   219                                                      
REMARK 465     SER H   220                                                      
REMARK 465     ASN H   221                                                      
REMARK 465     SER H   222                                                      
REMARK 465     LYS H   223                                                      
REMARK 465     TYR H   224                                                      
REMARK 465     SER H   225                                                      
REMARK 465     LEU H   226                                                      
REMARK 465     ASN H   227                                                      
REMARK 465     THR H   228                                                      
REMARK 465     ASP H   229                                                      
REMARK 465     SER H   230                                                      
REMARK 465     SER H   231                                                      
REMARK 465     VAL H   232                                                      
REMARK 465     SER H   233                                                      
REMARK 465     TYR H   234                                                      
REMARK 465     ILE H   235                                                      
REMARK 465     ASP H   236                                                      
REMARK 465     SER H   237                                                      
REMARK 465     ALA H   238                                                      
REMARK 465     VAL H   239                                                      
REMARK 465     ILE H   240                                                      
REMARK 465     SER H   241                                                      
REMARK 465     PRO H   242                                                      
REMARK 465     ASP H   243                                                      
REMARK 465     THR H   244                                                      
REMARK 465     VAL H   245                                                      
REMARK 465     PRO H   246                                                      
REMARK 465     LEU H   247                                                      
REMARK 465     GLY H   248                                                      
REMARK 465     THR H   249                                                      
REMARK 465     GLY H   250                                                      
REMARK 465     THR H   251                                                      
REMARK 465     SER H   252                                                      
REMARK 465     ILE H   253                                                      
REMARK 465     LEU H   254                                                      
REMARK 465     SER H   255                                                      
REMARK 465     LYS H   256                                                      
REMARK 465     GLN H   257                                                      
REMARK 465     VAL H   258                                                      
REMARK 465     GLN H   259                                                      
REMARK 465     ASN H   260                                                      
REMARK 465     LYS H   261                                                      
REMARK 465     PRO H   262                                                      
REMARK 465     LYS H   263                                                      
REMARK 465     THR H   264                                                      
REMARK 465     GLY H   265                                                      
REMARK 465     ARG H   266                                                      
REMARK 465     SER H   267                                                      
REMARK 465     LEU H   268                                                      
REMARK 465     LEU H   269                                                      
REMARK 465     GLY H   270                                                      
REMARK 465     GLY H   271                                                      
REMARK 465     PRO H   272                                                      
REMARK 465     ALA H   273                                                      
REMARK 465     ALA H   274                                                      
REMARK 465     LEU H   275                                                      
REMARK 465     SER H   276                                                      
REMARK 465     PRO H   277                                                      
REMARK 465     LEU H   278                                                      
REMARK 465     THR H   279                                                      
REMARK 465     PRO H   280                                                      
REMARK 465     SER H   281                                                      
REMARK 465     PHE H   282                                                      
REMARK 465     GLY H   283                                                      
REMARK 465     ILE H   284                                                      
REMARK 465     LEU H   285                                                      
REMARK 465     PRO H   286                                                      
REMARK 465     LEU H   287                                                      
REMARK 465     GLU H   288                                                      
REMARK 465     THR H   289                                                      
REMARK 465     PRO H   290                                                      
REMARK 465     SER H   291                                                      
REMARK 465     PRO H   292                                                      
REMARK 465     GLY H   293                                                      
REMARK 465     ASP H   294                                                      
REMARK 465     GLY H   295                                                      
REMARK 465     SER H   296                                                      
REMARK 465     TYR H   297                                                      
REMARK 465     LEU H   298                                                      
REMARK 465     GLN H   299                                                      
REMARK 465     ASN H   300                                                      
REMARK 465     TYR H   301                                                      
REMARK 465     THR H   302                                                      
REMARK 465     ASN H   303                                                      
REMARK 465     THR H   304                                                      
REMARK 465     PRO H   305                                                      
REMARK 465     PRO H   306                                                      
REMARK 465     VAL H   307                                                      
REMARK 465     ILE H   308                                                      
REMARK 465     ASP H   309                                                      
REMARK 465     VAL H   310                                                      
REMARK 465     PRO H   311                                                      
REMARK 465     SER H   312                                                      
REMARK 465     THR H   313                                                      
REMARK 465     GLY H   314                                                      
REMARK 465     ALA H   315                                                      
REMARK 465     PRO H   316                                                      
REMARK 465     SER H   317                                                      
REMARK 465     LYS H   318                                                      
REMARK 465     LYS H   319                                                      
REMARK 465     SER H   320                                                      
REMARK 465     VAL H   321                                                      
REMARK 465     ALA H   322                                                      
REMARK 465     ARG H   323                                                      
REMARK 465     ILE H   324                                                      
REMARK 465     GLY H   325                                                      
REMARK 465     GLN H   326                                                      
REMARK 465     THR H   327                                                      
REMARK 465     GLY H   328                                                      
REMARK 465     THR H   329                                                      
REMARK 465     LYS H   330                                                      
REMARK 465     SER H   331                                                      
REMARK 465     VAL H   332                                                      
REMARK 465     PHE H   333                                                      
REMARK 465     SER H   334                                                      
REMARK 465     GLN H   335                                                      
REMARK 465     SER H   336                                                      
REMARK 465     GLY H   337                                                      
REMARK 465     ASN H   338                                                      
REMARK 465     SER H   339                                                      
REMARK 465     ARG H   340                                                      
REMARK 465     GLU H   341                                                      
REMARK 465     VAL H   342                                                      
REMARK 465     THR H   343                                                      
REMARK 465     PRO H   344                                                      
REMARK 465     ILE H   345                                                      
REMARK 465     LEU H   346                                                      
REMARK 465     ALA H   347                                                      
REMARK 465     GLN H   348                                                      
REMARK 465     THR H   349                                                      
REMARK 465     GLN H   350                                                      
REMARK 465     SER H   351                                                      
REMARK 465     SER H   352                                                      
REMARK 465     GLY H   353                                                      
REMARK 465     PRO H   354                                                      
REMARK 465     GLN H   355                                                      
REMARK 465     THR H   356                                                      
REMARK 465     SER H   357                                                      
REMARK 465     THR H   358                                                      
REMARK 465     THR H   359                                                      
REMARK 465     PRO H   360                                                      
REMARK 465     GLN H   361                                                      
REMARK 465     VAL H   362                                                      
REMARK 465     LEU H   363                                                      
REMARK 465     SER H   364                                                      
REMARK 465     PRO H   365                                                      
REMARK 465     THR H   366                                                      
REMARK 465     ILE H   367                                                      
REMARK 465     THR H   368                                                      
REMARK 465     SER H   369                                                      
REMARK 465     PRO H   370                                                      
REMARK 465     PRO H   371                                                      
REMARK 465     ASN H   372                                                      
REMARK 465     ALA H   373                                                      
REMARK 465     LEU H   374                                                      
REMARK 465     PRO H   375                                                      
REMARK 465     ARG H   376                                                      
REMARK 465     ARG H   377                                                      
REMARK 465     SER H   378                                                      
REMARK 465     SER H   379                                                      
REMARK 465     ARG H   380                                                      
REMARK 465     LEU H   381                                                      
REMARK 465     PHE H   382                                                      
REMARK 465     THR H   383                                                      
REMARK 465     SER H   384                                                      
REMARK 465     ASP H   385                                                      
REMARK 465     SER H   386                                                      
REMARK 465     SER H   387                                                      
REMARK 465     THR H   388                                                      
REMARK 465     THR H   389                                                      
REMARK 465     LYS H   390                                                      
REMARK 465     GLU H   391                                                      
REMARK 465     ASN H   392                                                      
REMARK 465     SER H   393                                                      
REMARK 465     LYS H   394                                                      
REMARK 465     LYS H   395                                                      
REMARK 465     LEU H   396                                                      
REMARK 465     LYS H   397                                                      
REMARK 465     MET H   398                                                      
REMARK 465     LYS H   399                                                      
REMARK 465     PHE H   400                                                      
REMARK 465     PRO H   401                                                      
REMARK 465     PRO H   402                                                      
REMARK 465     LYS H   403                                                      
REMARK 465     ILE H   404                                                      
REMARK 465     PRO H   405                                                      
REMARK 465     ASN H   406                                                      
REMARK 465     ARG H   407                                                      
REMARK 465     LYS H   408                                                      
REMARK 465     THR H   409                                                      
REMARK 465     LYS H   410                                                      
REMARK 465     SER H   411                                                      
REMARK 465     LYS H   412                                                      
REMARK 465     THR H   413                                                      
REMARK 465     ASN H   414                                                      
REMARK 465     LYS H   415                                                      
REMARK 465     GLY H   416                                                      
REMARK 465     GLY H   417                                                      
REMARK 465     ILE H   418                                                      
REMARK 465     THR H   419                                                      
REMARK 465     GLN H   420                                                      
REMARK 465     PRO H   421                                                      
REMARK 465     ASN H   422                                                      
REMARK 465     ILE H   423                                                      
REMARK 465     ASN H   424                                                      
REMARK 465     ASP H   425                                                      
REMARK 465     SER H   426                                                      
REMARK 465     LEU H   427                                                      
REMARK 465     GLU H   428                                                      
REMARK 465     ILE H   429                                                      
REMARK 465     THR H   430                                                      
REMARK 465     LYS H   431                                                      
REMARK 465     LEU H   432                                                      
REMARK 465     ASP H   433                                                      
REMARK 465     SER H   434                                                      
REMARK 465     SER H   435                                                      
REMARK 465     ILE H   436                                                      
REMARK 465     ILE H   437                                                      
REMARK 465     SER H   438                                                      
REMARK 465     GLU H   439                                                      
REMARK 465     GLY H   440                                                      
REMARK 465     LYS H   441                                                      
REMARK 465     ILE H   442                                                      
REMARK 465     SER H   443                                                      
REMARK 465     THR H   444                                                      
REMARK 465     ILE H   445                                                      
REMARK 465     THR H   446                                                      
REMARK 465     PRO H   447                                                      
REMARK 465     GLN H   448                                                      
REMARK 465     ILE H   449                                                      
REMARK 465     GLN H   450                                                      
REMARK 465     PRO H   768                                                      
REMARK 465     LYS H   769                                                      
REMARK 465     GLY H   770                                                      
REMARK 465     ALA H   771                                                      
REMARK 465     ASN H   772                                                      
REMARK 465     ASN H   773                                                      
REMARK 465     GLN H   774                                                      
REMARK 465     ILE H   775                                                      
REMARK 465     LYS H   776                                                      
REMARK 465     GLU H   777                                                      
REMARK 465     ALA H   778                                                      
REMARK 465     ILE H   779                                                      
REMARK 465     ASP H   780                                                      
REMARK 465     LYS H   781                                                      
REMARK 465     ARG H   782                                                      
REMARK 465     TYR H   783                                                      
REMARK 465     LEU H   784                                                      
REMARK 465     PRO H   785                                                      
REMARK 465     ASP H   786                                                      
REMARK 465     ASP H   787                                                      
REMARK 465     GLU H   788                                                      
REMARK 465     GLU H   789                                                      
REMARK 465     PRO H   790                                                      
REMARK 465     ILE H   791                                                      
REMARK 465     THR H   792                                                      
REMARK 465     GLN H   793                                                      
REMARK 465     GLU H   794                                                      
REMARK 465     GLU H   795                                                      
REMARK 465     GLN H   796                                                      
REMARK 465     ILE H   797                                                      
REMARK 465     MET H   798                                                      
REMARK 465     GLY H   799                                                      
REMARK 465     THR H   800                                                      
REMARK 465     ASP H   801                                                      
REMARK 465     GLU H   802                                                      
REMARK 465     SER H   803                                                      
REMARK 465     GLN H   804                                                      
REMARK 465     GLU H   805                                                      
REMARK 465     SER H   806                                                      
REMARK 465     SER H   807                                                      
REMARK 465     MET H   808                                                      
REMARK 465     THR H   809                                                      
REMARK 465     ASP H   810                                                      
REMARK 465     ALA H   811                                                      
REMARK 465     ASP H   812                                                      
REMARK 465     ASP H   813                                                      
REMARK 465     THR H   814                                                      
REMARK 465     GLN H   815                                                      
REMARK 465     LEU H   816                                                      
REMARK 465     HIS H   817                                                      
REMARK 465     ALA H   818                                                      
REMARK 465     ALA H   819                                                      
REMARK 465     GLU H   820                                                      
REMARK 465     SER H   821                                                      
REMARK 465     ASP H   822                                                      
REMARK 465     GLU H   823                                                      
REMARK 465     PHE H   824                                                      
REMARK 465     MET I     1                                                      
REMARK 465     LEU I     2                                                      
REMARK 465     ARG I     3                                                      
REMARK 465     PHE I     4                                                      
REMARK 465     PRO I     5                                                      
REMARK 465     ASN I   130                                                      
REMARK 465     ALA I   131                                                      
REMARK 465     ASN I   457                                                      
REMARK 465     GLU I   458                                                      
REMARK 465     ALA I   459                                                      
REMARK 465     PRO I   460                                                      
REMARK 465     ASP I   461                                                      
REMARK 465     LEU I   462                                                      
REMARK 465     TYR I   463                                                      
REMARK 465     ASN I   464                                                      
REMARK 465     ARG I   465                                                      
REMARK 465     LYS I   466                                                      
REMARK 465     GLY I   467                                                      
REMARK 465     LYS I   468                                                      
REMARK 465     TYR I   469                                                      
REMARK 465     PHE I   470                                                      
REMARK 465     ASN I   471                                                      
REMARK 465     VAL I   472                                                      
REMARK 465     GLU I   473                                                      
REMARK 465     SER I   758                                                      
REMARK 465     ASP I   759                                                      
REMARK 465     GLU I   760                                                      
REMARK 465     GLU I   761                                                      
REMARK 465     GLU I   762                                                      
REMARK 465     GLU I   763                                                      
REMARK 465     ALA I   764                                                      
REMARK 465     SER I   765                                                      
REMARK 465     ASN I   766                                                      
REMARK 465     LYS I   767                                                      
REMARK 465     PRO I   768                                                      
REMARK 465     VAL I   769                                                      
REMARK 465     LYS I   770                                                      
REMARK 465     ILE I   771                                                      
REMARK 465     LYS I   772                                                      
REMARK 465     GLU I   773                                                      
REMARK 465     GLU I   774                                                      
REMARK 465     VAL I   775                                                      
REMARK 465     LEU I   776                                                      
REMARK 465     SER I   777                                                      
REMARK 465     GLU I   778                                                      
REMARK 465     SER I   779                                                      
REMARK 465     GLU I   780                                                      
REMARK 465     ALA I   781                                                      
REMARK 465     GLU I   782                                                      
REMARK 465     ASN I   783                                                      
REMARK 465     GLN I   784                                                      
REMARK 465     GLN I   785                                                      
REMARK 465     ALA I   786                                                      
REMARK 465     GLY I   787                                                      
REMARK 465     ALA I   788                                                      
REMARK 465     ALA I   789                                                      
REMARK 465     ALA I   790                                                      
REMARK 465     LEU I   791                                                      
REMARK 465     ALA I   792                                                      
REMARK 465     PRO I   793                                                      
REMARK 465     GLU I   794                                                      
REMARK 465     ILE I   795                                                      
REMARK 465     VAL I   796                                                      
REMARK 465     ILE I   797                                                      
REMARK 465     LYS I   798                                                      
REMARK 465     VAL I   799                                                      
REMARK 465     GLU I   800                                                      
REMARK 465     LYS I   801                                                      
REMARK 465     LEU I   802                                                      
REMARK 465     ASP I   803                                                      
REMARK 465     PRO I   804                                                      
REMARK 465     GLU I   805                                                      
REMARK 465     LEU I   806                                                      
REMARK 465     ASP I   807                                                      
REMARK 465     SER I   808                                                      
REMARK 465     MET J     1                                                      
REMARK 465     GLU J    96                                                      
REMARK 465     GLU J    97                                                      
REMARK 465     PRO J    98                                                      
REMARK 465     ILE J    99                                                      
REMARK 465     ASN J   100                                                      
REMARK 465     LYS J   101                                                      
REMARK 465     ARG J   102                                                      
REMARK 465     LEU J   103                                                      
REMARK 465     PHE J   104                                                      
REMARK 465     GLU J   105                                                      
REMARK 465     LYS J   106                                                      
REMARK 465     TYR J   107                                                      
REMARK 465     LEU J   108                                                      
REMARK 465     LYS J   109                                                      
REMARK 465     ASP J   110                                                      
REMARK 465     GLU J   111                                                      
REMARK 465     SER J   112                                                      
REMARK 465     GLY J   113                                                      
REMARK 465     PHE J   114                                                      
REMARK 465     LYS J   115                                                      
REMARK 465     ASP J   116                                                      
REMARK 465     PRO J   117                                                      
REMARK 465     SER J   118                                                      
REMARK 465     SER J   119                                                      
REMARK 465     ASP J   120                                                      
REMARK 465     TRP J   121                                                      
REMARK 465     GLU J   122                                                      
REMARK 465     MET J   123                                                      
REMARK 465     ILE J   534                                                      
REMARK 465     GLY J   535                                                      
REMARK 465     ALA J   536                                                      
REMARK 465     ASP J   537                                                      
REMARK 465     ILE J   538                                                      
REMARK 465     LYS J   539                                                      
REMARK 465     ASP J   540                                                      
REMARK 465     LYS J   541                                                      
REMARK 465     LEU J   542                                                      
REMARK 465     LYS J   543                                                      
REMARK 465     CYS J   544                                                      
REMARK 465     TYR J   545                                                      
REMARK 465     ASP J   546                                                      
REMARK 465     PHE J   547                                                      
REMARK 465     ASP J   548                                                      
REMARK 465     VAL J   549                                                      
REMARK 465     HIS J   550                                                      
REMARK 465     THR J   551                                                      
REMARK 465     MET J   552                                                      
REMARK 465     LYS J   553                                                      
REMARK 465     THR J   554                                                      
REMARK 465     LEU J   555                                                      
REMARK 465     LYS J   556                                                      
REMARK 465     ASN J   557                                                      
REMARK 465     ILE J   558                                                      
REMARK 465     ILE J   559                                                      
REMARK 465     SER J   560                                                      
REMARK 465     PRO J   561                                                      
REMARK 465     PRO J   562                                                      
REMARK 465     TRP J   563                                                      
REMARK 465     ASP J   564                                                      
REMARK 465     PHE J   565                                                      
REMARK 465     ARG J   566                                                      
REMARK 465     GLU J   567                                                      
REMARK 465     PHE J   568                                                      
REMARK 465     GLU J   569                                                      
REMARK 465     VAL J   570                                                      
REMARK 465     GLU J   571                                                      
REMARK 465     LYS J   572                                                      
REMARK 465     GLN J   573                                                      
REMARK 465     THR J   574                                                      
REMARK 465     ALA J   575                                                      
REMARK 465     GLU J   576                                                      
REMARK 465     GLU J   577                                                      
REMARK 465     THR J   578                                                      
REMARK 465     GLY J   579                                                      
REMARK 465     LEU J   580                                                      
REMARK 465     THR J   581                                                      
REMARK 465     PRO J   582                                                      
REMARK 465     LEU J   583                                                      
REMARK 465     GLU J   584                                                      
REMARK 465     THR J   585                                                      
REMARK 465     SER J   586                                                      
REMARK 465     ARG J   587                                                      
REMARK 465     LYS J   588                                                      
REMARK 465     THR J   589                                                      
REMARK 465     PRO J   590                                                      
REMARK 465     ASP J   591                                                      
REMARK 465     SER J   592                                                      
REMARK 465     ARG J   593                                                      
REMARK 465     PRO J   594                                                      
REMARK 465     SER J   595                                                      
REMARK 465     LEU J   596                                                      
REMARK 465     GLU J   597                                                      
REMARK 465     GLU J   598                                                      
REMARK 465     THR J   599                                                      
REMARK 465     PHE J   600                                                      
REMARK 465     GLU J   601                                                      
REMARK 465     ILE J   602                                                      
REMARK 465     GLU J   603                                                      
REMARK 465     MET J   604                                                      
REMARK 465     ASN J   605                                                      
REMARK 465     GLU J   606                                                      
REMARK 465     SER J   607                                                      
REMARK 465     ASP J   608                                                      
REMARK 465     MET J   609                                                      
REMARK 465     MET J   610                                                      
REMARK 465     LEU J   611                                                      
REMARK 465     GLU J   612                                                      
REMARK 465     THR J   613                                                      
REMARK 465     SER J   614                                                      
REMARK 465     MET J   615                                                      
REMARK 465     SER J   616                                                      
REMARK 465     ASP J   617                                                      
REMARK 465     HIS J   618                                                      
REMARK 465     SER J   619                                                      
REMARK 465     THR J   620                                                      
REMARK 465     MET K     1                                                      
REMARK 465     ASP K    94                                                      
REMARK 465     MET K    95                                                      
REMARK 465     GLU K    96                                                      
REMARK 465     GLU K    97                                                      
REMARK 465     PRO K    98                                                      
REMARK 465     ILE K    99                                                      
REMARK 465     ASN K   100                                                      
REMARK 465     LYS K   101                                                      
REMARK 465     ARG K   102                                                      
REMARK 465     LEU K   103                                                      
REMARK 465     PHE K   104                                                      
REMARK 465     GLU K   105                                                      
REMARK 465     LYS K   106                                                      
REMARK 465     TYR K   107                                                      
REMARK 465     LEU K   108                                                      
REMARK 465     LYS K   109                                                      
REMARK 465     ASP K   110                                                      
REMARK 465     GLU K   111                                                      
REMARK 465     SER K   112                                                      
REMARK 465     GLY K   113                                                      
REMARK 465     PHE K   114                                                      
REMARK 465     LYS K   115                                                      
REMARK 465     ASP K   116                                                      
REMARK 465     PRO K   117                                                      
REMARK 465     SER K   118                                                      
REMARK 465     SER K   119                                                      
REMARK 465     ASP K   120                                                      
REMARK 465     TRP K   121                                                      
REMARK 465     GLU K   122                                                      
REMARK 465     MET K   123                                                      
REMARK 465     SER K   124                                                      
REMARK 465     GLN K   125                                                      
REMARK 465     SER K   126                                                      
REMARK 465     GLY K   528                                                      
REMARK 465     ASP K   529                                                      
REMARK 465     SER K   530                                                      
REMARK 465     GLU K   531                                                      
REMARK 465     ALA K   532                                                      
REMARK 465     TYR K   533                                                      
REMARK 465     ILE K   534                                                      
REMARK 465     GLY K   535                                                      
REMARK 465     ALA K   536                                                      
REMARK 465     ASP K   537                                                      
REMARK 465     ILE K   538                                                      
REMARK 465     LYS K   539                                                      
REMARK 465     ASP K   540                                                      
REMARK 465     LYS K   541                                                      
REMARK 465     LEU K   542                                                      
REMARK 465     LYS K   543                                                      
REMARK 465     CYS K   544                                                      
REMARK 465     TYR K   545                                                      
REMARK 465     ASP K   546                                                      
REMARK 465     PHE K   547                                                      
REMARK 465     ASP K   548                                                      
REMARK 465     VAL K   549                                                      
REMARK 465     HIS K   550                                                      
REMARK 465     THR K   551                                                      
REMARK 465     MET K   552                                                      
REMARK 465     LYS K   553                                                      
REMARK 465     THR K   554                                                      
REMARK 465     LEU K   555                                                      
REMARK 465     LYS K   556                                                      
REMARK 465     ASN K   557                                                      
REMARK 465     ILE K   558                                                      
REMARK 465     ILE K   559                                                      
REMARK 465     SER K   560                                                      
REMARK 465     PRO K   561                                                      
REMARK 465     PRO K   562                                                      
REMARK 465     TRP K   563                                                      
REMARK 465     ASP K   564                                                      
REMARK 465     PHE K   565                                                      
REMARK 465     ARG K   566                                                      
REMARK 465     GLU K   567                                                      
REMARK 465     PHE K   568                                                      
REMARK 465     GLU K   569                                                      
REMARK 465     VAL K   570                                                      
REMARK 465     GLU K   571                                                      
REMARK 465     LYS K   572                                                      
REMARK 465     GLN K   573                                                      
REMARK 465     THR K   574                                                      
REMARK 465     ALA K   575                                                      
REMARK 465     GLU K   576                                                      
REMARK 465     GLU K   577                                                      
REMARK 465     THR K   578                                                      
REMARK 465     GLY K   579                                                      
REMARK 465     LEU K   580                                                      
REMARK 465     THR K   581                                                      
REMARK 465     PRO K   582                                                      
REMARK 465     LEU K   583                                                      
REMARK 465     GLU K   584                                                      
REMARK 465     THR K   585                                                      
REMARK 465     SER K   586                                                      
REMARK 465     ARG K   587                                                      
REMARK 465     LYS K   588                                                      
REMARK 465     THR K   589                                                      
REMARK 465     PRO K   590                                                      
REMARK 465     ASP K   591                                                      
REMARK 465     SER K   592                                                      
REMARK 465     ARG K   593                                                      
REMARK 465     PRO K   594                                                      
REMARK 465     SER K   595                                                      
REMARK 465     LEU K   596                                                      
REMARK 465     GLU K   597                                                      
REMARK 465     GLU K   598                                                      
REMARK 465     THR K   599                                                      
REMARK 465     PHE K   600                                                      
REMARK 465     GLU K   601                                                      
REMARK 465     ILE K   602                                                      
REMARK 465     GLU K   603                                                      
REMARK 465     MET K   604                                                      
REMARK 465     ASN K   605                                                      
REMARK 465     GLU K   606                                                      
REMARK 465     SER K   607                                                      
REMARK 465     ASP K   608                                                      
REMARK 465     MET K   609                                                      
REMARK 465     MET K   610                                                      
REMARK 465     LEU K   611                                                      
REMARK 465     GLU K   612                                                      
REMARK 465     THR K   613                                                      
REMARK 465     SER K   614                                                      
REMARK 465     MET K   615                                                      
REMARK 465     SER K   616                                                      
REMARK 465     ASP K   617                                                      
REMARK 465     HIS K   618                                                      
REMARK 465     SER K   619                                                      
REMARK 465     THR K   620                                                      
REMARK 465     MET L     1                                                      
REMARK 465     THR L     2                                                      
REMARK 465     GLU L   162A                                                     
REMARK 465     GLU M    40                                                      
REMARK 465     GLN M    41                                                      
REMARK 465     ASP M    42                                                      
REMARK 465     ASN M    43                                                      
REMARK 465     GLY M    44                                                      
REMARK 465     GLY M    45                                                      
REMARK 465     THR M    46                                                      
REMARK 465     THR M    47                                                      
REMARK 465     ASN M    68                                                      
REMARK 465     VAL M    69                                                      
REMARK 465     PRO M    70                                                      
REMARK 465     PRO M    71                                                      
REMARK 465     ILE M    72                                                      
REMARK 465     GLY M    73                                                      
REMARK 465     ASN M    74                                                      
REMARK 465     MET N    14                                                      
REMARK 465     GLY N    29A                                                     
REMARK 465     GLN N    29B                                                     
REMARK 465     GLU N    29C                                                     
REMARK 465     LEU N    29D                                                     
REMARK 465     LEU N    29E                                                     
REMARK 465     VAL N    29F                                                     
REMARK 465     ALA N    29G                                                     
REMARK 465     TRP N    29H                                                     
REMARK 465     ASN N    29I                                                     
REMARK 465     THR N    29J                                                     
REMARK 465     VAL N    29K                                                     
REMARK 465     SER N    29L                                                     
REMARK 465     THR N    29M                                                     
REMARK 465     GLY N    29N                                                     
REMARK 465     LEU N    29O                                                     
REMARK 465     VAL N    29P                                                     
REMARK 465     PRO N    29Q                                                     
REMARK 465     PRO N    29R                                                     
REMARK 465     ALA N    29S                                                     
REMARK 465     ALA N    29T                                                     
REMARK 465     LEU N    29U                                                     
REMARK 465     GLY N    29V                                                     
REMARK 465     LEU N    29W                                                     
REMARK 465     VAL N    29X                                                     
REMARK 465     SER N    29Y                                                     
REMARK 465     SER N    29Z                                                     
REMARK 465     ARG N    30A                                                     
REMARK 465     THR N    30B                                                     
REMARK 465     SER N    30C                                                     
REMARK 465     GLY N    30D                                                     
REMARK 465     GLU N    65A                                                     
REMARK 465     VAL N    65B                                                     
REMARK 465     LEU N    65C                                                     
REMARK 465     ARG N    65D                                                     
REMARK 465     GLY N    65E                                                     
REMARK 465     HIS N    65F                                                     
REMARK 465     GLY N    65G                                                     
REMARK 465     LEU N    65H                                                     
REMARK 465     HIS N    65I                                                     
REMARK 465     SER N    65J                                                     
REMARK 465     ASP N   103                                                      
REMARK 465     GLU N   104                                                      
REMARK 465     PRO N   105                                                      
REMARK 465     GLN N   106                                                      
REMARK 465     GLU N   192                                                      
REMARK 465     GLY N   193                                                      
REMARK 465     GLY N   194                                                      
REMARK 465     THR N   195                                                      
REMARK 465     CYS N   221                                                      
REMARK 465     ALA N   222                                                      
REMARK 465     GLY N   223                                                      
REMARK 465     CYS N   224                                                      
REMARK 465     SER N   225                                                      
REMARK 465     SER N   226                                                      
REMARK 465     ASP N   227                                                      
REMARK 465     LYS N   228                                                      
REMARK 465     GLN N   229                                                      
REMARK 465     GLN N   230                                                      
REMARK 465     CYS N   231                                                      
REMARK 465     LEU N   305                                                      
REMARK 465     GLN N   306                                                      
REMARK 465     ASP N   307                                                      
REMARK 465     GLY N   308                                                      
REMARK 465     PRO N   309                                                      
REMARK 465     ALA N   310                                                      
REMARK 465     ARG N   311                                                      
REMARK 465     PRO N   312                                                      
REMARK 465     ALA N   313                                                      
REMARK 465     SER N   314                                                      
REMARK 465     PRO N   315                                                      
REMARK 465     GLU N   316                                                      
REMARK 465     ALA N   317                                                      
REMARK 465     GLY N   318                                                      
REMARK 465     ASN N   319                                                      
REMARK 465     GLY N   443A                                                     
REMARK 465     ASP N   443B                                                     
REMARK 465     SER N   443C                                                     
REMARK 465     ASP N   443D                                                     
REMARK 465     GLY N   443E                                                     
REMARK 465     THR N   443F                                                     
REMARK 465     GLY N   443G                                                     
REMARK 465     ASP N   443H                                                     
REMARK 465     LEU N   443I                                                     
REMARK 465     ALA N   443J                                                     
REMARK 465     VAL N   443K                                                     
REMARK 465     GLU N   443L                                                     
REMARK 465     LEU N   443M                                                     
REMARK 465     SER N   443N                                                     
REMARK 465     LYS N   443O                                                     
REMARK 465     THR N   443P                                                     
REMARK 465     ASP N   443Q                                                     
REMARK 465     PRO N   443R                                                     
REMARK 465     SER N   470                                                      
REMARK 465     GLU N   471                                                      
REMARK 465     ASP N   472                                                      
REMARK 465     ASP N   473                                                      
REMARK 465     SER N   474                                                      
REMARK 465     GLY N   475                                                      
REMARK 465     ASP N   731                                                      
REMARK 465     SER N   732                                                      
REMARK 465     ASP N   733                                                      
REMARK 465     ASP N   734                                                      
REMARK 465     GLU N   735                                                      
REMARK 465     SER N   736                                                      
REMARK 465     ASP N   737                                                      
REMARK 465     SER N   738                                                      
REMARK 465     GLY N   739                                                      
REMARK 465     MET N   740                                                      
REMARK 465     ALA N   741                                                      
REMARK 465     SER N   742                                                      
REMARK 465     GLN N   743                                                      
REMARK 465     ALA N   744                                                      
REMARK 465     ASP N   745                                                      
REMARK 465     GLN N   746                                                      
REMARK 465     LYS N   819                                                      
REMARK 465     ASN N   820                                                      
REMARK 465     CYS N   821                                                      
REMARK 465     SER N   822                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     SER O     3                                                      
REMARK 465     VAL O     4                                                      
REMARK 465     HIS O     5                                                      
REMARK 465     GLU O     6                                                      
REMARK 465     SER O     7                                                      
REMARK 465     LEU O     8                                                      
REMARK 465     TYR O     9                                                      
REMARK 465     PHE O    10                                                      
REMARK 465     ASN O    11                                                      
REMARK 465     PRO O    12                                                      
REMARK 465     MET O    13                                                      
REMARK 465     MET O    14                                                      
REMARK 465     THR O    15                                                      
REMARK 465     ASN O    16                                                      
REMARK 465     GLY O    17                                                      
REMARK 465     VAL O    18                                                      
REMARK 465     VAL O    19                                                      
REMARK 465     HIS O    20                                                      
REMARK 465     ALA O    21                                                      
REMARK 465     ASN O    22                                                      
REMARK 465     VAL O    23                                                      
REMARK 465     PHE O    24                                                      
REMARK 465     GLY O    25                                                      
REMARK 465     ILE O    26                                                      
REMARK 465     VAL O   170                                                      
REMARK 465     GLU O   171                                                      
REMARK 465     ASP O   172                                                      
REMARK 465     ALA O   173                                                      
REMARK 465     ASP O   174                                                      
REMARK 465     MET O   175                                                      
REMARK 465     GLU O   176                                                      
REMARK 465     LEU O   177                                                      
REMARK 465     THR O   178                                                      
REMARK 465     SER O   179                                                      
REMARK 465     ARG O   180                                                      
REMARK 465     ASP O   181                                                      
REMARK 465     GLU O   182                                                      
REMARK 465     GLY O   183                                                      
REMARK 465     GLU O   184                                                      
REMARK 465     ARG O   185                                                      
REMARK 465     LYS O   186                                                      
REMARK 465     MET O   187                                                      
REMARK 465     GLU O   188                                                      
REMARK 465     LYS O   189                                                      
REMARK 465     GLU O   190                                                      
REMARK 465     GLU O   191                                                      
REMARK 465     LEU O   192                                                      
REMARK 465     ASP O   193                                                      
REMARK 465     VAL O   194                                                      
REMARK 465     SER O   195                                                      
REMARK 465     VAL O   196                                                      
REMARK 465     ARG O   197                                                      
REMARK 465     GLU O   198                                                      
REMARK 465     GLU O   199                                                      
REMARK 465     GLU O   200                                                      
REMARK 465     VAL O   201                                                      
REMARK 465     SER O   202                                                      
REMARK 465     CYS O   203                                                      
REMARK 465     SER O   204                                                      
REMARK 465     GLY O   205                                                      
REMARK 465     ALA O   453                                                      
REMARK 465     VAL O   454                                                      
REMARK 465     ASN O   455                                                      
REMARK 465     ALA O   456                                                      
REMARK 465     GLY O   457                                                      
REMARK 465     VAL O   458                                                      
REMARK 465     HIS O   747                                                      
REMARK 465     GLY O   748                                                      
REMARK 465     MET P     1                                                      
REMARK 465     ALA P     2                                                      
REMARK 465     ALA P     3                                                      
REMARK 465     SER P     4                                                      
REMARK 465     THR P     5                                                      
REMARK 465     SER P     6                                                      
REMARK 465     MET P     7                                                      
REMARK 465     VAL P     8                                                      
REMARK 465     PRO P     9                                                      
REMARK 465     VAL P    10                                                      
REMARK 465     ALA P    11                                                      
REMARK 465     VAL P    12                                                      
REMARK 465     THR P    13                                                      
REMARK 465     ALA P    14                                                      
REMARK 465     ALA P    15                                                      
REMARK 465     VAL P    16                                                      
REMARK 465     ALA P    17                                                      
REMARK 465     PRO P    18                                                      
REMARK 465     VAL P    19                                                      
REMARK 465     LEU P    20                                                      
REMARK 465     SER P    21                                                      
REMARK 465     ILE P    22                                                      
REMARK 465     ASN P    23                                                      
REMARK 465     SER P    24                                                      
REMARK 465     ASP P    25                                                      
REMARK 465     VAL P   135                                                      
REMARK 465     ASP P   136                                                      
REMARK 465     SER P   137                                                      
REMARK 465     LEU P   138                                                      
REMARK 465     GLY P   139                                                      
REMARK 465     PRO P   140                                                      
REMARK 465     LEU P   141                                                      
REMARK 465     GLU P   142                                                      
REMARK 465     LYS P   143                                                      
REMARK 465     GLY P   144                                                      
REMARK 465     GLN P   145                                                      
REMARK 465     VAL P   146                                                      
REMARK 465     GLY P   501                                                      
REMARK 465     GLU P   502                                                      
REMARK 465     ILE P   503                                                      
REMARK 465     VAL P   504                                                      
REMARK 465     GLU P   505                                                      
REMARK 465     HIS P   506                                                      
REMARK 465     LEU P   507                                                      
REMARK 465     GLU P   508                                                      
REMARK 465     GLU P   509                                                      
REMARK 465     SER P   510                                                      
REMARK 465     PHE P   539                                                      
REMARK 465     ASN P   540                                                      
REMARK 465     ASP P   541                                                      
REMARK 465     THR P   542                                                      
REMARK 465     ARG P   543                                                      
REMARK 465     GLU P   544                                                      
REMARK 465     GLU P   545                                                      
REMARK 465     GLY P   546                                                      
REMARK 465     LYS P   547                                                      
REMARK 465     ALA P   548                                                      
REMARK 465     LEU P   549                                                      
REMARK 465     LEU P   550                                                      
REMARK 465     ARG P   551                                                      
REMARK 465     GLN P   552                                                      
REMARK 465     ILE P   553                                                      
REMARK 465     LEU P   554                                                      
REMARK 465     GLN P   555                                                      
REMARK 465     LEU P   556                                                      
REMARK 465     ARG P   557                                                      
REMARK 465     ASN P   558                                                      
REMARK 465     GLN P   559                                                      
REMARK 465     GLY P   560                                                      
REMARK 465     GLU P   561                                                      
REMARK 465     THR P   562                                                      
REMARK 465     PRO P   563                                                      
REMARK 465     THR P   564                                                      
REMARK 465     THR P   565                                                      
REMARK 465     GLU P   566                                                      
REMARK 465     VAL P   567                                                      
REMARK 465     PRO P   568                                                      
REMARK 465     ALA P   569                                                      
REMARK 465     PRO P   570                                                      
REMARK 465     PHE P   571                                                      
REMARK 465     PHE P   572                                                      
REMARK 465     LEU P   573                                                      
REMARK 465     PRO P   574                                                      
REMARK 465     ALA P   575                                                      
REMARK 465     SER P   576                                                      
REMARK 465     LEU P   577                                                      
REMARK 465     SER P   578                                                      
REMARK 465     ALA P   579                                                      
REMARK 465     ASN P   580                                                      
REMARK 465     ASN P   581                                                      
REMARK 465     THR P   582                                                      
REMARK 465     PRO P   583                                                      
REMARK 465     THR P   584                                                      
REMARK 465     ARG P   585                                                      
REMARK 465     ARG P   586                                                      
REMARK 465     VAL P   587                                                      
REMARK 465     SER P   588                                                      
REMARK 465     PRO P   589                                                      
REMARK 465     LEU P   590                                                      
REMARK 465     ASN P   591                                                      
REMARK 465     LEU P   592                                                      
REMARK 465     SER P   593                                                      
REMARK 465     SER P   594                                                      
REMARK 465     VAL P   595                                                      
REMARK 465     THR P   596                                                      
REMARK 465     PRO P   597                                                      
REMARK 465     ARG Q   147                                                      
REMARK 465     LEU Q   148                                                      
REMARK 465     LYS Q   149                                                      
REMARK 465     VAL Q   150                                                      
REMARK 465     LEU Q   151                                                      
REMARK 465     TYR Q   152                                                      
REMARK 465     SER Q   153                                                      
REMARK 465     GLN Q   154                                                      
REMARK 465     LYS Q   155                                                      
REMARK 465     ALA Q   156                                                      
REMARK 465     THR Q   157                                                      
REMARK 465     ARG Q   483                                                      
REMARK 465     GLU Q   484                                                      
REMARK 465     LYS Q   485                                                      
REMARK 465     ALA Q   486                                                      
REMARK 465     SER Q   487                                                      
REMARK 465     ALA Q   488                                                      
REMARK 465     ALA Q   489                                                      
REMARK 465     LYS Q   490                                                      
REMARK 465     SER Q   491                                                      
REMARK 465     MET R     1                                                      
REMARK 465     ALA R     2                                                      
REMARK 465     GLN R     3                                                      
REMARK 465     PHE R     4                                                      
REMARK 465     ALA R     5                                                      
REMARK 465     PHE R     6                                                      
REMARK 465     GLU R     7                                                      
REMARK 465     SER R     8                                                      
REMARK 465     ASP R     9                                                      
REMARK 465     LEU R    10                                                      
REMARK 465     HIS R    11                                                      
REMARK 465     SER R    12                                                      
REMARK 465     LEU R    13                                                      
REMARK 465     LEU R    14                                                      
REMARK 465     GLN R    15                                                      
REMARK 465     LEU R    16                                                      
REMARK 465     ASP R    17                                                      
REMARK 465     ALA R    18                                                      
REMARK 465     PRO R    19                                                      
REMARK 465     ILE R    20                                                      
REMARK 465     PRO R    21                                                      
REMARK 465     ASN R    22                                                      
REMARK 465     ALA R    23                                                      
REMARK 465     PRO R    24                                                      
REMARK 465     PRO R    25                                                      
REMARK 465     ALA R    26                                                      
REMARK 465     ARG R    27                                                      
REMARK 465     TRP R    28                                                      
REMARK 465     GLN R    29                                                      
REMARK 465     ARG R    30                                                      
REMARK 465     LYS R    31                                                      
REMARK 465     ALA R    32                                                      
REMARK 465     LYS R    33                                                      
REMARK 465     GLU R    34                                                      
REMARK 465     ALA R    35                                                      
REMARK 465     ALA R    36                                                      
REMARK 465     GLY R    37                                                      
REMARK 465     PRO R    38                                                      
REMARK 465     ALA R    39                                                      
REMARK 465     PRO R    40                                                      
REMARK 465     SER R    41                                                      
REMARK 465     PRO R    42                                                      
REMARK 465     MET R    43                                                      
REMARK 465     ARG R    44                                                      
REMARK 465     ALA R    45                                                      
REMARK 465     ALA R    46                                                      
REMARK 465     ASN R    47                                                      
REMARK 465     ARG R    48                                                      
REMARK 465     SER R    49                                                      
REMARK 465     HIS R    50                                                      
REMARK 465     SER R    51                                                      
REMARK 465     ALA R    52                                                      
REMARK 465     GLY R    53                                                      
REMARK 465     ARG R    54                                                      
REMARK 465     THR R    55                                                      
REMARK 465     PRO R    56                                                      
REMARK 465     GLY R    57                                                      
REMARK 465     ARG R    58                                                      
REMARK 465     THR R    59                                                      
REMARK 465     PRO R    60                                                      
REMARK 465     GLY R    61                                                      
REMARK 465     LYS R    62                                                      
REMARK 465     SER R    63                                                      
REMARK 465     SER R    64                                                      
REMARK 465     SER R    65                                                      
REMARK 465     LYS R    66                                                      
REMARK 465     VAL R    67                                                      
REMARK 465     GLN R    68                                                      
REMARK 465     THR R    69                                                      
REMARK 465     THR R    70                                                      
REMARK 465     PRO R    71                                                      
REMARK 465     SER R    72                                                      
REMARK 465     LYS R   136                                                      
REMARK 465     PRO R   137                                                      
REMARK 465     GLN R   138                                                      
REMARK 465     ASN R   139                                                      
REMARK 465     ALA R   140                                                      
REMARK 465     PRO R   141                                                      
REMARK 465     GLU R   142                                                      
REMARK 465     GLY R   143                                                      
REMARK 465     TYR R   144                                                      
REMARK 465     GLN R   145                                                      
REMARK 465     ASN R   146                                                      
REMARK 465     ARG R   147                                                      
REMARK 465     LEU R   148                                                      
REMARK 465     LYS R   149                                                      
REMARK 465     VAL R   150                                                      
REMARK 465     LEU R   151                                                      
REMARK 465     TYR R   152                                                      
REMARK 465     SER R   153                                                      
REMARK 465     GLN R   154                                                      
REMARK 465     LYS R   155                                                      
REMARK 465     ALA R   156                                                      
REMARK 465     THR R   157                                                      
REMARK 465     PRO R   158                                                      
REMARK 465     GLY R   159                                                      
REMARK 465     SER R   160                                                      
REMARK 465     SER R   161                                                      
REMARK 465     ARG R   162                                                      
REMARK 465     LYS R   163                                                      
REMARK 465     THR R   164                                                      
REMARK 465     PRO R   477                                                      
REMARK 465     ALA R   478                                                      
REMARK 465     ARG R   479                                                      
REMARK 465     ARG R   480                                                      
REMARK 465     ARG R   481                                                      
REMARK 465     GLU R   482                                                      
REMARK 465     ARG R   483                                                      
REMARK 465     GLU R   484                                                      
REMARK 465     LYS R   485                                                      
REMARK 465     ALA R   486                                                      
REMARK 465     SER R   487                                                      
REMARK 465     ALA R   488                                                      
REMARK 465     ALA R   489                                                      
REMARK 465     LYS R   490                                                      
REMARK 465     SER R   491                                                      
REMARK 465     MET S     1                                                      
REMARK 465     ALA S     2                                                      
REMARK 465     ALA S     3                                                      
REMARK 465     VAL S     4                                                      
REMARK 465     LYS S     5                                                      
REMARK 465     LYS S     6                                                      
REMARK 465     GLU S     7                                                      
REMARK 465     GLY S     8                                                      
REMARK 465     GLY S     9                                                      
REMARK 465     ALA S    10                                                      
REMARK 465     LEU S    11                                                      
REMARK 465     SER S    12                                                      
REMARK 465     GLU S    13                                                      
REMARK 465     ALA S    14                                                      
REMARK 465     MET S    15                                                      
REMARK 465     SER S    16                                                      
REMARK 465     LEU S    17                                                      
REMARK 465     GLU S    18                                                      
REMARK 465     LEU S   208                                                      
REMARK 465     GLU S   209                                                      
REMARK 465     LYS S   210                                                      
REMARK 465     GLU S   211                                                      
REMARK 465     GLU S   212                                                      
REMARK 465     GLU S   213                                                      
REMARK 465     GLU S   214                                                      
REMARK 465     GLU S   215                                                      
REMARK 465     VAL S   216                                                      
REMARK 465     PHE S   217                                                      
REMARK 465     GLU S   218                                                      
REMARK 465     SER S   219                                                      
REMARK 465     SER S   220                                                      
REMARK 465     ALA S   240                                                      
REMARK 465     PRO S   241                                                      
REMARK 465     ILE S   242                                                      
REMARK 465     ILE S   243                                                      
REMARK 465     ARG S   244                                                      
REMARK 465     VAL S   245                                                      
REMARK 465     GLY S   246                                                      
REMARK 465     GLY S   247                                                      
REMARK 465     ALA S   248                                                      
REMARK 465     LEU S   249                                                      
REMARK 465     LYS S   250                                                      
REMARK 465     ALA S   251                                                      
REMARK 465     PRO S   252                                                      
REMARK 465     SER S   253                                                      
REMARK 465     GLN S   254                                                      
REMARK 465     PHE S   534                                                      
REMARK 465     LEU S   535                                                      
REMARK 465     LEU S   536                                                      
REMARK 465     SER S   537                                                      
REMARK 465     GLU S   538                                                      
REMARK 465     LYS S   539                                                      
REMARK 465     LYS S   540                                                      
REMARK 465     ASN S   541                                                      
REMARK 465     LYS S   542                                                      
REMARK 465     SER S   543                                                      
REMARK 465     PRO S   544                                                      
REMARK 465     PRO S   545                                                      
REMARK 465     ALA S   546                                                      
REMARK 465     ASP S   547                                                      
REMARK 465     PRO S   548                                                      
REMARK 465     PRO S   549                                                      
REMARK 465     ARG S   550                                                      
REMARK 465     VAL S   551                                                      
REMARK 465     LEU S   552                                                      
REMARK 465     LEU W    26                                                      
REMARK 465     GLU W    27                                                      
REMARK 465     THR W    28                                                      
REMARK 465     ARG W    29                                                      
REMARK 465     LYS W    30                                                      
REMARK 465     LYS W    31                                                      
REMARK 465     GLN W    32                                                      
REMARK 465     LYS W    33                                                      
REMARK 465     GLU W    34                                                      
REMARK 465     ASP W    35                                                      
REMARK 465     VAL W    36                                                      
REMARK 465     GLU W    37                                                      
REMARK 465     VAL W    38                                                      
REMARK 465     VAL W    39                                                      
REMARK 465     GLY W    40                                                      
REMARK 465     GLY W    41                                                      
REMARK 465     SER W    42                                                      
REMARK 465     ASP W    43                                                      
REMARK 465     GLY W    44                                                      
REMARK 465     GLU W    45                                                      
REMARK 465     GLY W    46                                                      
REMARK 465     ALA W    47                                                      
REMARK 465     ILE W    48                                                      
REMARK 465     GLY W    49                                                      
REMARK 465     LEU W    50                                                      
REMARK 465     SER W    51                                                      
REMARK 465     SER W    52                                                      
REMARK 465     ASP W    53                                                      
REMARK 465     PRO W    54                                                      
REMARK 465     LYS W    55                                                      
REMARK 465     SER W    56                                                      
REMARK 465     ARG W    57                                                      
REMARK 465     GLU W    58                                                      
REMARK 465     GLN W    59                                                      
REMARK 465     MET W    60                                                      
REMARK 465     ILE W    61                                                      
REMARK 465     ASN W    62                                                      
REMARK 465     ASP W    63                                                      
REMARK 465     ARG W    64                                                      
REMARK 465     ILE W    65                                                      
REMARK 465     GLY W    66                                                      
REMARK 465     TYR W    67                                                      
REMARK 465     LYS W    68                                                      
REMARK 465     PRO W    69                                                      
REMARK 465     GLN W    70                                                      
REMARK 465     PRO W    71                                                      
REMARK 465     LYS W    72                                                      
REMARK 465     PRO W    73                                                      
REMARK 465     ASN W    74                                                      
REMARK 465     ASN W    75                                                      
REMARK 465     ARG W    76                                                      
REMARK 465     SER W    77                                                      
REMARK 465     SER W    78                                                      
REMARK 465     GLN W    79                                                      
REMARK 465     PHE W    80                                                      
REMARK 465     GLY W    81                                                      
REMARK 465     SER W    82                                                      
REMARK 465     LEU W    83                                                      
REMARK 465     GLU W    84                                                      
REMARK 465     PHE W    85                                                      
REMARK 465     MET X     1                                                      
REMARK 465     ASP X     2                                                      
REMARK 465     PRO X     3                                                      
REMARK 465     GLY X     4                                                      
REMARK 465     ASP X     5                                                      
REMARK 465     ALA X     6                                                      
REMARK 465     ALA X     7                                                      
REMARK 465     ILE X     8                                                      
REMARK 465     LEU X     9                                                      
REMARK 465     GLU X    10                                                      
REMARK 465     SER X    11                                                      
REMARK 465     SER X    12                                                      
REMARK 465     LEU X    13                                                      
REMARK 465     ARG X    14                                                      
REMARK 465     ILE X    15                                                      
REMARK 465     LEU X    16                                                      
REMARK 465     TYR X    17                                                      
REMARK 465     ARG X    18                                                      
REMARK 465     LEU X    19                                                      
REMARK 465     PHE X    20                                                      
REMARK 465     GLU X    21                                                      
REMARK 465     SER X    22                                                      
REMARK 465     VAL X    23                                                      
REMARK 465     LEU X    24                                                      
REMARK 465     PRO X    25                                                      
REMARK 465     PRO X    26                                                      
REMARK 465     LEU X    27                                                      
REMARK 465     PRO X    28                                                      
REMARK 465     ALA X    29                                                      
REMARK 465     ALA X    30                                                      
REMARK 465     LEU X    31                                                      
REMARK 465     GLN X    32                                                      
REMARK 465     SER X    33                                                      
REMARK 465     ARG X    34                                                      
REMARK 465     MET X    35                                                      
REMARK 465     SER X   111                                                      
REMARK 465     LYS X   112                                                      
REMARK 465     THR X   113                                                      
REMARK 465     SER X   114                                                      
REMARK 465     LYS X   115                                                      
REMARK 465     VAL X   116                                                      
REMARK 465     ARG X   117                                                      
REMARK 465     PRO X   118                                                      
REMARK 465     SER X   119                                                      
REMARK 465     THR X   120                                                      
REMARK 465     GLY X   121                                                      
REMARK 465     ASN X   122                                                      
REMARK 465     SER X   123                                                      
REMARK 465     ALA X   124                                                      
REMARK 465     SER X   125                                                      
REMARK 465     THR X   126                                                      
REMARK 465     PRO X   127                                                      
REMARK 465     GLN X   128                                                      
REMARK 465     SER X   129                                                      
REMARK 465     GLN X   130                                                      
REMARK 465     CYS X   131                                                      
REMARK 465     ASN X   541                                                      
REMARK 465     ASP X   542                                                      
REMARK 465     GLN X   543                                                      
REMARK 465     LYS X   544                                                      
REMARK 465     SER X   545                                                      
REMARK 465     LEU X   546                                                      
REMARK 465     GLU X   547                                                      
REMARK 465     GLY X   548                                                      
REMARK 465     MET X   549                                                      
REMARK 465     GLN X   550                                                      
REMARK 465     LYS X   551                                                      
REMARK 465     MET X   552                                                      
REMARK 465     GLU X   553                                                      
REMARK 465     LYS X   554                                                      
REMARK 465     GLU X   555                                                      
REMARK 465     GLU X   556                                                      
REMARK 465     SER X   557                                                      
REMARK 465     PRO X   558                                                      
REMARK 465     THR X   559                                                      
REMARK 465     ASP X   560                                                      
REMARK 465     ALA X   561                                                      
REMARK 465     THR X   562                                                      
REMARK 465     GLN X   563                                                      
REMARK 465     GLU X   564                                                      
REMARK 465     GLU X   565                                                      
REMARK 465     ASP X   566                                                      
REMARK 465     VAL X   567                                                      
REMARK 465     ASP X   568                                                      
REMARK 465     ASP X   569                                                      
REMARK 465     MET X   570                                                      
REMARK 465     GLU X   571                                                      
REMARK 465     GLY X   572                                                      
REMARK 465     SER X   573                                                      
REMARK 465     GLY X   574                                                      
REMARK 465     GLU X   575                                                      
REMARK 465     GLU X   576                                                      
REMARK 465     GLY X   577                                                      
REMARK 465     ASP X   578                                                      
REMARK 465     LEU X   579                                                      
REMARK 465     GLU X   580                                                      
REMARK 465     GLY X   581                                                      
REMARK 465     SER X   582                                                      
REMARK 465     ASP X   583                                                      
REMARK 465     SER X   584                                                      
REMARK 465     GLU X   585                                                      
REMARK 465     ALA X   586                                                      
REMARK 465     ALA X   587                                                      
REMARK 465     GLN X   588                                                      
REMARK 465     TRP X   589                                                      
REMARK 465     ALA X   590                                                      
REMARK 465     ASP X   591                                                      
REMARK 465     GLN X   592                                                      
REMARK 465     GLU X   593                                                      
REMARK 465     GLN X   594                                                      
REMARK 465     TRP X   595                                                      
REMARK 465     PHE X   596                                                      
REMARK 465     GLY X   597                                                      
REMARK 465     MET X   598                                                      
REMARK 465     GLN X   599                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     ASP Y     2                                                      
REMARK 465     PRO Y     3                                                      
REMARK 465     GLY Y     4                                                      
REMARK 465     ASP Y     5                                                      
REMARK 465     ALA Y     6                                                      
REMARK 465     ALA Y     7                                                      
REMARK 465     ILE Y     8                                                      
REMARK 465     LEU Y     9                                                      
REMARK 465     GLU Y    10                                                      
REMARK 465     SER Y    11                                                      
REMARK 465     SER Y    12                                                      
REMARK 465     LEU Y    13                                                      
REMARK 465     ARG Y    14                                                      
REMARK 465     ILE Y    15                                                      
REMARK 465     LEU Y    16                                                      
REMARK 465     TYR Y    17                                                      
REMARK 465     ARG Y    18                                                      
REMARK 465     LEU Y    19                                                      
REMARK 465     PHE Y    20                                                      
REMARK 465     GLU Y    21                                                      
REMARK 465     SER Y    22                                                      
REMARK 465     VAL Y    23                                                      
REMARK 465     LEU Y    24                                                      
REMARK 465     PRO Y    25                                                      
REMARK 465     PRO Y    26                                                      
REMARK 465     LEU Y    27                                                      
REMARK 465     PRO Y    28                                                      
REMARK 465     ALA Y    29                                                      
REMARK 465     ALA Y    30                                                      
REMARK 465     LEU Y    31                                                      
REMARK 465     GLN Y    32                                                      
REMARK 465     SER Y    33                                                      
REMARK 465     ARG Y    34                                                      
REMARK 465     MET Y    35                                                      
REMARK 465     SER Y   111                                                      
REMARK 465     LYS Y   112                                                      
REMARK 465     THR Y   113                                                      
REMARK 465     SER Y   114                                                      
REMARK 465     LYS Y   115                                                      
REMARK 465     VAL Y   116                                                      
REMARK 465     ARG Y   117                                                      
REMARK 465     PRO Y   118                                                      
REMARK 465     SER Y   119                                                      
REMARK 465     THR Y   120                                                      
REMARK 465     GLY Y   121                                                      
REMARK 465     ASN Y   122                                                      
REMARK 465     SER Y   123                                                      
REMARK 465     ALA Y   124                                                      
REMARK 465     SER Y   125                                                      
REMARK 465     THR Y   126                                                      
REMARK 465     PRO Y   127                                                      
REMARK 465     GLN Y   128                                                      
REMARK 465     SER Y   129                                                      
REMARK 465     GLN Y   130                                                      
REMARK 465     CYS Y   131                                                      
REMARK 465     GLU Y   553                                                      
REMARK 465     LYS Y   554                                                      
REMARK 465     GLU Y   555                                                      
REMARK 465     GLU Y   556                                                      
REMARK 465     SER Y   557                                                      
REMARK 465     PRO Y   558                                                      
REMARK 465     THR Y   559                                                      
REMARK 465     ASP Y   560                                                      
REMARK 465     ALA Y   561                                                      
REMARK 465     THR Y   562                                                      
REMARK 465     GLN Y   563                                                      
REMARK 465     GLU Y   564                                                      
REMARK 465     GLU Y   565                                                      
REMARK 465     ASP Y   566                                                      
REMARK 465     VAL Y   567                                                      
REMARK 465     ASP Y   568                                                      
REMARK 465     ASP Y   569                                                      
REMARK 465     MET Y   570                                                      
REMARK 465     GLU Y   571                                                      
REMARK 465     GLY Y   572                                                      
REMARK 465     SER Y   573                                                      
REMARK 465     GLY Y   574                                                      
REMARK 465     GLU Y   575                                                      
REMARK 465     GLU Y   576                                                      
REMARK 465     GLY Y   577                                                      
REMARK 465     ASP Y   578                                                      
REMARK 465     LEU Y   579                                                      
REMARK 465     GLU Y   580                                                      
REMARK 465     GLY Y   581                                                      
REMARK 465     SER Y   582                                                      
REMARK 465     ASP Y   583                                                      
REMARK 465     SER Y   584                                                      
REMARK 465     GLU Y   585                                                      
REMARK 465     ALA Y   586                                                      
REMARK 465     ALA Y   587                                                      
REMARK 465     GLN Y   588                                                      
REMARK 465     TRP Y   589                                                      
REMARK 465     ALA Y   590                                                      
REMARK 465     ASP Y   591                                                      
REMARK 465     GLN Y   592                                                      
REMARK 465     GLU Y   593                                                      
REMARK 465     GLN Y   594                                                      
REMARK 465     TRP Y   595                                                      
REMARK 465     PHE Y   596                                                      
REMARK 465     GLY Y   597                                                      
REMARK 465     MET Y   598                                                      
REMARK 465     GLN Y   599                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     ALA Z     2                                                      
REMARK 465     LEU Z     3                                                      
REMARK 465     GLN Z     4                                                      
REMARK 465     LEU Z     5                                                      
REMARK 465     SER Z     6                                                      
REMARK 465     ARG Z     7                                                      
REMARK 465     VAL Z   203                                                      
REMARK 465     ASN Z   204                                                      
REMARK 465     ASP Z   205                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LEU A  48    CG   CD1  CD2                                       
REMARK 470     TRP A  49    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP A  49    CZ3  CH2                                            
REMARK 470     SER A  50    OG                                                  
REMARK 470     SER A  51    OG                                                  
REMARK 470     ASP A  52    CG   OD1  OD2                                       
REMARK 470     LEU A  57    CG   CD1  CD2                                       
REMARK 470     VAL A  58    CG1  CG2                                            
REMARK 470     LYS A  71    CG   CD   CE   NZ                                   
REMARK 470     GLU A  82    CG   CD   OE1  OE2                                  
REMARK 470     ILE A  83    CG1  CG2  CD1                                       
REMARK 470     GLN A 109    CG   CD   OE1  NE2                                  
REMARK 470     GLU A 146    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 148    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 184    CG   CD   CE   NZ                                   
REMARK 470     PRO A 206    CG   CD                                             
REMARK 470     GLU A 219    CG   CD   OE1  OE2                                  
REMARK 470     VAL A 236    CG1  CG2                                            
REMARK 470     ASP A 241    CG   OD1  OD2                                       
REMARK 470     ASN A 264    CG   OD1  ND2                                       
REMARK 470     LYS A 275    CG   CD   CE   NZ                                   
REMARK 470     SER A 276    OG                                                  
REMARK 470     GLU A 277    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 278    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 279    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 280    CG   OD1  ND2                                       
REMARK 470     ASN A 346    CG   OD1  ND2                                       
REMARK 470     MET A 347    CG   SD   CE                                        
REMARK 470     LEU A 350    CG   CD1  CD2                                       
REMARK 470     SER A 351    OG                                                  
REMARK 470     ARG A 352    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS A 354    CB   CG   ND1  CD2  CE1  NE2                        
REMARK 470     SER A 355    CB   OG                                             
REMARK 470     LEU A 358    CG   CD1  CD2                                       
REMARK 470     VAL A 360    CG1  CG2                                            
REMARK 470     CYS A 408    SG                                                  
REMARK 470     THR A 414    OG1  CG2                                            
REMARK 470     ASN A 424    CG   OD1  ND2                                       
REMARK 470     SER A 425    OG                                                  
REMARK 470     GLU A 447    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 465    CG   CD   OE1  NE2                                  
REMARK 470     LYS A 484    CG   CD   CE   NZ                                   
REMARK 470     ASP A 486    CG   OD1  OD2                                       
REMARK 470     GLU A 492    CG   CD   OE1  OE2                                  
REMARK 470     SER A 494    OG                                                  
REMARK 470     LYS A 631    CG   CD   CE   NZ                                   
REMARK 470     GLU A 632    CG   CD   OE1  OE2                                  
REMARK 470     PRO A 651    CG   CD                                             
REMARK 470     TYR A 670    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     VAL A 814    CG1  CG2                                            
REMARK 470     SER A 839    OG                                                  
REMARK 470     GLU A 840    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 855    CG   CD   OE1  OE2                                  
REMARK 470     MET A 857    CG   SD   CE                                        
REMARK 470     LYS A 985    CG   CD   CE   NZ                                   
REMARK 470     GLN A 986    CG   CD   OE1  NE2                                  
REMARK 470     TYR A1054    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU A1056    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1098    CG   CD   OE1  OE2                                  
REMARK 470     ASP A1126    CG   OD1  OD2                                       
REMARK 470     MET A1285    CG   SD   CE                                        
REMARK 470     GLU A1286    CG   CD   OE1  OE2                                  
REMARK 470     CYS A1288    SG                                                  
REMARK 470     ASP A1318    CG   OD1  OD2                                       
REMARK 470     ASP A1356    CG   OD1  OD2                                       
REMARK 470     THR A1357    OG1  CG2                                            
REMARK 470     MET A1393    CG   SD   CE                                        
REMARK 470     GLU A1402    CG   CD   OE1  OE2                                  
REMARK 470     ASP A1418    CG   OD1  OD2                                       
REMARK 470     ASN A1422    CG   OD1  ND2                                       
REMARK 470     ARG A1435    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A1436    CG   CD   OE1  OE2                                  
REMARK 470     ASN A1437    CG   OD1  ND2                                       
REMARK 470     LEU A1452    CG   CD1  CD2                                       
REMARK 470     GLU A1549    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1659    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1680    CG   CD1  CD2                                       
REMARK 470     LYS A1709    CG   CD   CE   NZ                                   
REMARK 470     ASN A1727    CG   OD1  ND2                                       
REMARK 470     ASN A1760    CG   OD1  ND2                                       
REMARK 470     LYS A1764    CG   CD   CE   NZ                                   
REMARK 470     ARG A1803    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS A1826    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLN A1827    CG   CD   OE1  NE2                                  
REMARK 470     GLU A1843    CG   CD   OE1  OE2                                  
REMARK 470     VAL A1862    CG1  CG2                                            
REMARK 470     GLU A1879    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1889    CG   CD1  CD2                                       
REMARK 470     GLU A1913    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1914    CG   CD1  CD2                                       
REMARK 470     LEU A1915    CG   CD1  CD2                                       
REMARK 470     PHE A1916    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS A1917    CG   CD   CE   NZ                                   
REMARK 470     PHE A1918    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS A1919    CG   CD   CE   NZ                                   
REMARK 470     GLN A1920    CG   CD   OE1  NE2                                  
REMARK 470     LEU A1921    CG   CD1  CD2                                       
REMARK 470     LYS A1922    CG   CD   CE   NZ                                   
REMARK 470     MET A1923    CG   SD   CE                                        
REMARK 470     PRO A1924    CG   CD                                             
REMARK 470     VAL A1925    CG1  CG2                                            
REMARK 470     ARG A1926    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A1928    CG   CD1  CD2                                       
REMARK 470     LEU A1929    CG   CD1  CD2                                       
REMARK 470     ARG A1930    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A1931    CG   CD1  CD2                                       
REMARK 470     PRO A1933    CG   CD                                             
REMARK 470     LEU A1934    CG   CD1  CD2                                       
REMARK 470     LEU A1935    CG   CD1  CD2                                       
REMARK 470     LEU A1936    CG   CD1  CD2                                       
REMARK 470     GLU C  69    CG   CD   OE1  OE2                                  
REMARK 470     CYS C 109    SG                                                  
REMARK 470     LYS C 281    CG   CD   CE   NZ                                   
REMARK 470     ASP C 496    CG   OD1  OD2                                       
REMARK 470     SER C 499    OG                                                  
REMARK 470     CYS C 500    SG                                                  
REMARK 470     ARG E  52    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU E  54    CG   CD1  CD2                                       
REMARK 470     CYS E  55    SG                                                  
REMARK 470     GLN F   5    CG   CD   OE1  NE2                                  
REMARK 470     PHE F 168    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS F 169    CG   CD   CE   NZ                                   
REMARK 470     PHE F 170    CB   CG   CD1  CD2  CE1  CE2  CZ                    
REMARK 470     PHE F 452    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN F 453    CG   OD1  ND2                                       
REMARK 470     LEU F 454    CG   CD1  CD2                                       
REMARK 470     LYS F 456    CG   CD   CE   NZ                                   
REMARK 470     ASP F 767    CG   OD1  OD2                                       
REMARK 470     LYS G  24    CG   CD   CE   NZ                                   
REMARK 470     ASP G  25    CG   OD1  OD2                                       
REMARK 470     GLN H   5    CG   CD   OE1  NE2                                  
REMARK 470     PHE H 168    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS H 169    CG   CD   CE   NZ                                   
REMARK 470     PHE H 170    CB   CG   CD1  CD2  CE1  CE2  CZ                    
REMARK 470     PHE H 452    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN H 453    CG   OD1  ND2                                       
REMARK 470     LEU H 454    CG   CD1  CD2                                       
REMARK 470     ASP H 767    CG   OD1  OD2                                       
REMARK 470     PHE I 128    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TYR I 129    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU I 132    CD   OE1  OE2                                       
REMARK 470     ASP I 133    CG   OD1  OD2                                       
REMARK 470     ASN I 136    CG   OD1  ND2                                       
REMARK 470     LYS I 147    CG   CD   CE   NZ                                   
REMARK 470     ASN I 148    CG   OD1  ND2                                       
REMARK 470     TYR I 149    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN I 151    CG   OD1  ND2                                       
REMARK 470     THR I 152    OG1  CG2                                            
REMARK 470     LYS I 154    CG   CD   CE   NZ                                   
REMARK 470     GLU I 159    CG   CD   OE1  OE2                                  
REMARK 470     ASN I 160    CG   OD1  ND2                                       
REMARK 470     GLN I 292    CG   CD   OE1  NE2                                  
REMARK 470     GLU I 293    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 294    CG   CD   CE   NZ                                   
REMARK 470     ASN I 295    CG   OD1  ND2                                       
REMARK 470     THR I 296    OG1  CG2                                            
REMARK 470     THR I 297    OG1  CG2                                            
REMARK 470     THR I 298    OG1  CG2                                            
REMARK 470     SER I 299    OG                                                  
REMARK 470     LYS I 346    CG   CD   CE   NZ                                   
REMARK 470     GLU I 402    CG   CD   OE1  OE2                                  
REMARK 470     MET I 411    CG   SD   CE                                        
REMARK 470     LYS I 412    CG   CD   CE   NZ                                   
REMARK 470     ASP I 431    CG   OD1  OD2                                       
REMARK 470     HIS I 432    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL I 433    CG1  CG2                                            
REMARK 470     LEU I 434    CG   CD1  CD2                                       
REMARK 470     PRO I 435    CG   CD                                             
REMARK 470     GLU I 436    CG   CD   OE1  OE2                                  
REMARK 470     LEU I 437    CG   CD1  CD2                                       
REMARK 470     ASN I 438    CG   OD1  ND2                                       
REMARK 470     LYS I 439    CG   CD   CE   NZ                                   
REMARK 470     LYS I 480    CG   CD   CE   NZ                                   
REMARK 470     ASP I 481    CG   OD1  OD2                                       
REMARK 470     GLU I 482    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 483    CG   OD1  OD2                                       
REMARK 470     ASP I 484    CG   OD1  OD2                                       
REMARK 470     ASP I 485    CG   OD1  OD2                                       
REMARK 470     LEU I 486    CG   CD1  CD2                                       
REMARK 470     VAL I 487    CG1  CG2                                            
REMARK 470     SER I 488    OG                                                  
REMARK 470     ASN I 495    CG   OD1  ND2                                       
REMARK 470     ARG I 567    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG I 659    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 660    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 662    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 756    CG   CD   OE1  OE2                                  
REMARK 470     ASN J   2    CG   OD1  ND2                                       
REMARK 470     LEU J   3    CG   CD1  CD2                                       
REMARK 470     GLU J   4    CG   CD   OE1  OE2                                  
REMARK 470     ARG J   5    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER J 124    OG                                                  
REMARK 470     GLN J 125    CG   CD   OE1  NE2                                  
REMARK 470     SER J 126    OG                                                  
REMARK 470     GLU J 222    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 347    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 524    CG   CD   OE1  OE2                                  
REMARK 470     ASP J 529    CG   OD1  OD2                                       
REMARK 470     SER J 530    OG                                                  
REMARK 470     GLU J 531    CG   CD   OE1  OE2                                  
REMARK 470     ASN K   2    CG   OD1  ND2                                       
REMARK 470     LEU K   3    CG   CD1  CD2                                       
REMARK 470     GLU K   4    CG   CD   OE1  OE2                                  
REMARK 470     ARG K   5    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS K 214    CG   CD   CE   NZ                                   
REMARK 470     SER L 164    OG                                                  
REMARK 470     SER L 165    OG                                                  
REMARK 470     ILE L 166    CG1  CG2  CD1                                       
REMARK 470     LYS L 168    CG   CD   CE   NZ                                   
REMARK 470     PHE L 169    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO L 170    CG   CD                                             
REMARK 470     ARG L 171    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     CYS L 172    SG                                                  
REMARK 470     THR L 173    OG1  CG2                                            
REMARK 470     THR L 174    OG1  CG2                                            
REMARK 470     ILE L 175    CG1  CG2  CD1                                       
REMARK 470     ASP L 176    CG   OD1  OD2                                       
REMARK 470     VAL N  18    CG1  CG2                                            
REMARK 470     VAL N  19    CG1  CG2                                            
REMARK 470     VAL N  20    CG1  CG2                                            
REMARK 470     GLU N  22    CG   CD   OE1  OE2                                  
REMARK 470     ASP N  24    CG   OD1  OD2                                       
REMARK 470     SER N  25    OG                                                  
REMARK 470     ASP N  26    CG   OD1  OD2                                       
REMARK 470     SER N  27    OG                                                  
REMARK 470     ARG N  28    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO N  29    CG   CD                                             
REMARK 470     VAL N  54    CG1  CG2                                            
REMARK 470     PRO N  55    CG   CD                                             
REMARK 470     PRO N  56    CG   CD                                             
REMARK 470     LYS N  57    CG   CD   CE   NZ                                   
REMARK 470     GLU N  58    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  59    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  60    CG   CD   OE1  OE2                                  
REMARK 470     LEU N  61    CG   CD1  CD2                                       
REMARK 470     ARG N  62    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL N  65    CG1  CG2                                            
REMARK 470     VAL N  70    CG1  CG2                                            
REMARK 470     LEU N  71    CG   CD1  CD2                                       
REMARK 470     GLU N  72    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  73    CG   CD   OE1  OE2                                  
REMARK 470     ASN N  93    CG   OD1  ND2                                       
REMARK 470     ILE N  95    CG1  CG2  CD1                                       
REMARK 470     SER N  96    OG                                                  
REMARK 470     GLN N  97    CG   CD   OE1  NE2                                  
REMARK 470     CYS N  98    SG                                                  
REMARK 470     GLU N  99    CG   CD   OE1  OE2                                  
REMARK 470     ASN N 100    CG   OD1  ND2                                       
REMARK 470     SER N 101    OG                                                  
REMARK 470     CYS N 107    SG                                                  
REMARK 470     LEU N 108    CG   CD1  CD2                                       
REMARK 470     LEU N 109    CG   CD1  CD2                                       
REMARK 470     LEU N 110    CG   CD1  CD2                                       
REMARK 470     LEU N 111    CG   CD1  CD2                                       
REMARK 470     LEU N 112    CG   CD1  CD2                                       
REMARK 470     ASP N 113    CG   OD1  OD2                                       
REMARK 470     PHE N 115    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU N 117    CG   CD1  CD2                                       
REMARK 470     LEU N 118    CG   CD1  CD2                                       
REMARK 470     GLU N 119    CG   CD   OE1  OE2                                  
REMARK 470     SER N 120    OG                                                  
REMARK 470     ARG N 121    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU N 122    CG   CD1  CD2                                       
REMARK 470     ASP N 123    CG   OD1  OD2                                       
REMARK 470     LEU N 126    CG   CD1  CD2                                       
REMARK 470     ARG N 127    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER N 128    OG                                                  
REMARK 470     GLU N 130    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 131    CG   CD1  CD2                                       
REMARK 470     LEU N 132    CG   CD1  CD2                                       
REMARK 470     GLU N 133    CG   CD   OE1  OE2                                  
REMARK 470     LYS N 134    CG   CD   CE   NZ                                   
REMARK 470     TRP N 135    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP N 135    CZ3  CH2                                            
REMARK 470     THR N 136    OG1  CG2                                            
REMARK 470     ARG N 137    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU N 138    CG   CD1  CD2                                       
REMARK 470     LEU N 140    CG   CD1  CD2                                       
REMARK 470     LEU N 141    CG   CD1  CD2                                       
REMARK 470     MET N 142    CG   SD   CE                                        
REMARK 470     THR N 144    OG1  CG2                                            
REMARK 470     GLN N 147    CG   CD   OE1  NE2                                  
REMARK 470     SER N 164    OG                                                  
REMARK 470     THR N 165    OG1  CG2                                            
REMARK 470     ASP N 196    CG   OD1  OD2                                       
REMARK 470     PRO N 197    CG   CD                                             
REMARK 470     GLU N 198    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 199    CG   CD1  CD2                                       
REMARK 470     GLU N 200    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 216    CG   CD1  CD2                                       
REMARK 470     GLN N 217    CG   CD   OE1  NE2                                  
REMARK 470     SER N 218    OG                                                  
REMARK 470     PRO N 219    CG   CD                                             
REMARK 470     LEU N 220    CG   CD1  CD2                                       
REMARK 470     GLU N 254    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 294    CG   CD   OE1  OE2                                  
REMARK 470     THR N 443    OG1  CG2                                            
REMARK 470     SER N 452    OG                                                  
REMARK 470     LEU N 453    CG   CD1  CD2                                       
REMARK 470     GLU N 454    CG   CD   OE1  OE2                                  
REMARK 470     THR N 455    OG1  CG2                                            
REMARK 470     GLN N 457    CG   CD   OE1  NE2                                  
REMARK 470     ASP N 458    CG   OD1  OD2                                       
REMARK 470     GLU N 476    CG   CD   OE1  OE2                                  
REMARK 470     PRO N 477    CG   CD                                             
REMARK 470     GLU N 478    CG   CD   OE1  OE2                                  
REMARK 470     ASP N 479    CG   OD1  OD2                                       
REMARK 470     TRP N 480    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP N 480    CZ3  CH2                                            
REMARK 470     VAL N 481    CG1  CG2                                            
REMARK 470     PRO N 482    CG   CD                                             
REMARK 470     ASP N 483    CG   OD1  OD2                                       
REMARK 470     PRO N 484    CG   CD                                             
REMARK 470     VAL N 485    CG1  CG2                                            
REMARK 470     ASP N 486    CG   OD1  OD2                                       
REMARK 470     ASP N 488    CG   OD1  OD2                                       
REMARK 470     PRO N 489    CG   CD                                             
REMARK 470     LYS N 491    CG   CD   CE   NZ                                   
REMARK 470     SER N 492    OG                                                  
REMARK 470     SER N 493    OG                                                  
REMARK 470     SER N 494    OG                                                  
REMARK 470     LYS N 495    CG   CD   CE   NZ                                   
REMARK 470     ARG N 496    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG N 497    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER N 499    OG                                                  
REMARK 470     LYS N 747    CG   CD   CE   NZ                                   
REMARK 470     GLU N 749    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 750    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 751    CG   CD1  CD2                                       
REMARK 470     GLU N 789    CG   CD   OE1  OE2                                  
REMARK 470     LYS N 801    CG   CD   CE   NZ                                   
REMARK 470     ARG N 804    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS O  27    CG   CD   CE   NZ                                   
REMARK 470     THR O  47    OG1  CG2                                            
REMARK 470     GLU O  49    CG   CD   OE1  OE2                                  
REMARK 470     VAL O  52    CG1  CG2                                            
REMARK 470     THR O 122    OG1  CG2                                            
REMARK 470     GLU O 123    CG   CD   OE1  OE2                                  
REMARK 470     LYS O 168    CG   CD   CE   NZ                                   
REMARK 470     THR O 169    OG1  CG2                                            
REMARK 470     LYS O 229    CG   CD   CE   NZ                                   
REMARK 470     GLU O 452    CG   CD   OE1  OE2                                  
REMARK 470     GLN O 742    CG   CD   OE1  NE2                                  
REMARK 470     GLU O 743    CG   CD   OE1  OE2                                  
REMARK 470     SER O 746    OG                                                  
REMARK 470     VAL O 749    CG1  CG2                                            
REMARK 470     GLU P  69    CG   CD   OE1  OE2                                  
REMARK 470     CYS P 109    SG                                                  
REMARK 470     LYS P 281    CG   CD   CE   NZ                                   
REMARK 470     ASP P 496    CG   OD1  OD2                                       
REMARK 470     ILE P 497    CD1                                                 
REMARK 470     SER P 499    OG                                                  
REMARK 470     CYS P 500    SG                                                  
REMARK 470     GLU Q 126    CG   CD   OE1  OE2                                  
REMARK 470     GLU Q 127    CG   CD   OE1  OE2                                  
REMARK 470     SER Q 134    OG                                                  
REMARK 470     LYS Q 136    CG   CD   CE   NZ                                   
REMARK 470     PRO Q 137    CG   CD                                             
REMARK 470     GLN Q 138    CG   CD   OE1  NE2                                  
REMARK 470     ASN Q 139    CG   OD1  ND2                                       
REMARK 470     PRO Q 141    CG   CD                                             
REMARK 470     GLN Q 145    CG   CD   OE1  NE2                                  
REMARK 470     ASN Q 146    CG   OD1  ND2                                       
REMARK 470     PRO Q 158    CG   CD                                             
REMARK 470     SER Q 160    OG                                                  
REMARK 470     SER Q 161    OG                                                  
REMARK 470     ARG Q 162    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR Q 164    OG1  CG2                                            
REMARK 470     PRO Q 477    CG   CD                                             
REMARK 470     ARG Q 479    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG Q 480    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG Q 481    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU Q 482    CG   CD   OE1  OE2                                  
REMARK 470     SER Q 492    OG                                                  
REMARK 470     LEU Q 493    CG   CD1  CD2                                       
REMARK 470     GLN Q 496    CG   CD   OE1  NE2                                  
REMARK 470     GLN R 100    CG   CD   OE1  NE2                                  
REMARK 470     GLU R 102    CG   CD   OE1  OE2                                  
REMARK 470     ASN R 103    CG   OD1  ND2                                       
REMARK 470     SER R 104    OG                                                  
REMARK 470     GLN R 105    CG   CD   OE1  NE2                                  
REMARK 470     THR R 106    OG1  CG2                                            
REMARK 470     SER R 492    OG                                                  
REMARK 470     LEU R 493    CG   CD1  CD2                                       
REMARK 470     LYS S  94    CG   CD   CE   NZ                                   
REMARK 470     GLU S  95    CG   CD   OE1  OE2                                  
REMARK 470     VAL S 221    CG1  CG2                                            
REMARK 470     PRO S 222    CG   CD                                             
REMARK 470     GLN S 223    CG   CD   OE1  NE2                                  
REMARK 470     GLU S 229    CG   CD   OE1  OE2                                  
REMARK 470     LEU S 230    CG   CD1  CD2                                       
REMARK 470     LYS S 231    CG   CD   CE   NZ                                   
REMARK 470     SER S 232    OG                                                  
REMARK 470     LYS S 233    CG   CD   CE   NZ                                   
REMARK 470     LYS S 235    CG   CD   CE   NZ                                   
REMARK 470     LYS S 236    CG   CD   CE   NZ                                   
REMARK 470     THR S 237    OG1  CG2                                            
REMARK 470     ARG S 239    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN S 255    CG   OD1  ND2                                       
REMARK 470     ARG S 256    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU S 258    CG   CD1  CD2                                       
REMARK 470     GLN S 259    CG   CD   OE1  NE2                                  
REMARK 470     ASN S 260    CG   OD1  ND2                                       
REMARK 470     PRO S 261    CG   CD                                             
REMARK 470     PHE S 262    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO S 263    CG   CD                                             
REMARK 470     GLN S 264    CG   CD   OE1  NE2                                  
REMARK 470     GLN S 265    CG   CD   OE1  NE2                                  
REMARK 470     MET S 266    CG   SD   CE                                        
REMARK 470     GLN S 267    CG   CD   OE1  NE2                                  
REMARK 470     ASN S 268    CG   OD1  ND2                                       
REMARK 470     GLU S 281    CG   CD   OE1  OE2                                  
REMARK 470     SER S 283    OG                                                  
REMARK 470     THR S 284    OG1  CG2                                            
REMARK 470     GLU S 286    CG   CD   OE1  OE2                                  
REMARK 470     LEU S 287    CG   CD1  CD2                                       
REMARK 470     SER S 288    OG                                                  
REMARK 470     LYS S 289    CG   CD   CE   NZ                                   
REMARK 470     PRO S 290    CG   CD                                             
REMARK 470     THR S 291    OG1  CG2                                            
REMARK 470     VAL S 292    CG1  CG2                                            
REMARK 470     GLN S 293    CG   CD   OE1  NE2                                  
REMARK 470     TRP S 295    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP S 295    CZ3  CH2                                            
REMARK 470     ILE S 296    CG1  CG2  CD1                                       
REMARK 470     MET S 300    CG   SD   CE                                        
REMARK 470     PRO S 301    CG   CD                                             
REMARK 470     ARG S 302    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU S 307    CG   CD   OE1  OE2                                  
REMARK 470     LEU S 308    CG   CD1  CD2                                       
REMARK 470     GLN S 309    CG   CD   OE1  NE2                                  
REMARK 470     SER S 529    OG                                                  
REMARK 470     ILE S 530    CG1  CG2  CD1                                       
REMARK 470     ASP S 532    CG   OD1  OD2                                       
REMARK 470     GLU S 533    CG   CD   OE1  OE2                                  
REMARK 470     GLN S 554    CG   CD   OE1  NE2                                  
REMARK 470     ARG S 556    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO S 557    CG   CD                                             
REMARK 470     VAL S 560    CG1  CG2                                            
REMARK 470     LYS W  24    CG   CD   CE   NZ                                   
REMARK 470     ASP W  25    CG   OD1  OD2                                       
REMARK 470     LYS X 215    CG   CD   CE   NZ                                   
REMARK 470     GLU X 218    CG   CD   OE1  OE2                                  
REMARK 470     MET X 224    CG   SD   CE                                        
REMARK 470     ASN X 225    CG   OD1  ND2                                       
REMARK 470     GLN X 228    CG   CD   OE1  NE2                                  
REMARK 470     ARG X 317    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU X 318    CG   CD   OE1  OE2                                  
REMARK 470     ASN X 440    CG   OD1  ND2                                       
REMARK 470     LYS Y 215    CG   CD   CE   NZ                                   
REMARK 470     GLU Y 218    CG   CD   OE1  OE2                                  
REMARK 470     MET Y 224    CG   SD   CE                                        
REMARK 470     ASN Y 225    CG   OD1  ND2                                       
REMARK 470     GLN Y 228    CG   CD   OE1  NE2                                  
REMARK 470     ARG Y 317    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU Y 318    CG   CD   OE1  OE2                                  
REMARK 470     ASN Y 440    CG   OD1  ND2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OE2  GLU S    86     NZ   LYS S   127              0.63            
REMARK 500   C    VAL B    17     O    ASN B    31              1.29            
REMARK 500   CD2  LEU S    75     CZ   TYR S   115              1.30            
REMARK 500   NE1  TRP B    16     O    CYS B    44              1.35            
REMARK 500   CD   GLU S    86     NZ   LYS S   127              1.40            
REMARK 500   NE2  GLN Y   442     NE   ARG Y   472              1.43            
REMARK 500   OE2  GLU I   430     OG1  THR Q   432              1.50            
REMARK 500   CD   GLN Y   442     NE   ARG Y   472              1.51            
REMARK 500   CZ   TYR C   115     NZ   LYS C   161              1.51            
REMARK 500   CE1  TYR C   115     NZ   LYS C   161              1.56            
REMARK 500   C    VAL B    17     C    ASN B    31              1.57            
REMARK 500   CE2  TRP B    16     O    CYS B    44              1.59            
REMARK 500   CA   VAL B    17     O    ASN B    31              1.64            
REMARK 500   CD2  LEU S    75     CE1  TYR S   115              1.65            
REMARK 500   O    VAL B    17     O    ASN B    31              1.66            
REMARK 500   CG   LEU S    75     CE1  TYR S   115              1.67            
REMARK 500   CD2  LEU S    75     OH   TYR S   115              1.68            
REMARK 500   OE2  GLU S    86     CE   LYS S   127              1.68            
REMARK 500   O    VAL B    17     C    ASN B    31              1.69            
REMARK 500   C    VAL B    17     CA   ASN B    31              1.70            
REMARK 500   SD   MET S    38     OH   TYR Z   199              1.74            
REMARK 500   CA   GLY S    19     NE2  GLN Z   134              1.74            
REMARK 500   CD   GLN X   442     NE   ARG X   472              1.78            
REMARK 500   N    VAL B    17     O    ASN B    31              1.83            
REMARK 500   OE1  GLN X   442     CZ   ARG X   472              1.85            
REMARK 500   O    GLY S    71     O    PRO S    74              1.86            
REMARK 500   NE1  TRP B    16     C    CYS B    44              1.87            
REMARK 500   OE1  GLN X   442     NH2  ARG X   472              1.87            
REMARK 500   O    GLY A  1332     CD1  ILE A  1358              1.91            
REMARK 500   O    ASP O   114     OD1  ASP O   117              1.93            
REMARK 500   OH   TYR C   115     NZ   LYS C   161              1.95            
REMARK 500   NE1  TRP B    16     CB   CYS B    44              1.96            
REMARK 500   OE1  GLN X   442     NE   ARG X   472              1.97            
REMARK 500   OE1  GLU I   186     NH1  ARG I   197              1.97            
REMARK 500   OE1  GLN Y   442     NE   ARG Y   472              1.97            
REMARK 500   CD2  LEU O    75     OH   TYR O   161              1.98            
REMARK 500   NE2  GLN Y   442     CZ   ARG Y   472              1.99            
REMARK 500   O    GLU S    21     CD2  LEU S    45              1.99            
REMARK 500   CD   GLU I   430     OG1  THR Q   432              2.00            
REMARK 500   CE   MET S    38     CG2  VAL Z   181              2.00            
REMARK 500   N    GLN S    30     NH2  ARG S    36              2.00            
REMARK 500   O    VAL N    78     N    ASN N    81              2.01            
REMARK 500   OH   TYR K   487     O    ASP W    15              2.01            
REMARK 500   O    LYS K   214     N    SER K   216              2.01            
REMARK 500   C    GLY S    19     NE2  GLN Z   134              2.04            
REMARK 500   O    GLN S    58     CD2  PHE S    62              2.04            
REMARK 500   O    VAL B    17     CA   ASN B    31              2.04            
REMARK 500   OD2  ASP L   126     O    LYS L   130              2.05            
REMARK 500   CH2  TRP S    22     O    MET S    38              2.05            
REMARK 500   O    LYS K   129     SG   CYS K   133              2.05            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      83 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    ARG A 795   NE    ARG A 795   CZ      0.089                       
REMARK 500    GLU A1030   CG    GLU A1030   CD      0.124                       
REMARK 500    GLU A1030   CD    GLU A1030   OE1     0.241                       
REMARK 500    GLU A1030   CD    GLU A1030   OE2     0.172                       
REMARK 500    LYS A1199   CE    LYS A1199   NZ      0.248                       
REMARK 500    LYS H 730   CE    LYS H 730   NZ      0.155                       
REMARK 500    TRP J 302   CB    TRP J 302   CG     -0.139                       
REMARK 500    TRP J 337   CB    TRP J 337   CG     -0.114                       
REMARK 500    TRP K 302   CB    TRP K 302   CG     -0.125                       
REMARK 500    ARG N 209   NE    ARG N 209   CZ      0.126                       
REMARK 500    ARG N 330   CZ    ARG N 330   NH2    -0.083                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ARG A 795   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.1 DEGREES          
REMARK 500    GLU A1030   CG  -  CD  -  OE2 ANGL. DEV. =  12.7 DEGREES          
REMARK 500    LEU A1168   CA  -  CB  -  CG  ANGL. DEV. =  14.6 DEGREES          
REMARK 500    LEU A1235   CB  -  CG  -  CD2 ANGL. DEV. = -14.9 DEGREES          
REMARK 500    PRO A1590   C   -  N   -  CA  ANGL. DEV. =   9.6 DEGREES          
REMARK 500    LEU A1603   CA  -  CB  -  CG  ANGL. DEV. =  16.1 DEGREES          
REMARK 500    PRO A1924   N   -  CA  -  CB  ANGL. DEV. =   7.3 DEGREES          
REMARK 500    PRO A1933   N   -  CA  -  CB  ANGL. DEV. =   7.9 DEGREES          
REMARK 500    LEU C 358   CB  -  CG  -  CD2 ANGL. DEV. = -10.3 DEGREES          
REMARK 500    LEU C 365   CA  -  CB  -  CG  ANGL. DEV. = -15.1 DEGREES          
REMARK 500    LEU H 462   CA  -  CB  -  CG  ANGL. DEV. =  13.8 DEGREES          
REMARK 500    VAL I 223   CB  -  CA  -  C   ANGL. DEV. = -11.6 DEGREES          
REMARK 500    LEU I 320   CB  -  CG  -  CD1 ANGL. DEV. = -11.4 DEGREES          
REMARK 500    PRO I 435   N   -  CA  -  CB  ANGL. DEV. =   7.9 DEGREES          
REMARK 500    PRO I 489   C   -  N   -  CA  ANGL. DEV. =   9.1 DEGREES          
REMARK 500    LEU J 134   CA  -  CB  -  CG  ANGL. DEV. =  14.8 DEGREES          
REMARK 500    LEU J 188   CA  -  CB  -  CG  ANGL. DEV. =  13.9 DEGREES          
REMARK 500    PRO J 221   C   -  N   -  CA  ANGL. DEV. =  17.4 DEGREES          
REMARK 500    PRO J 221   C   -  N   -  CD  ANGL. DEV. = -24.2 DEGREES          
REMARK 500    LEU J 376   CA  -  CB  -  CG  ANGL. DEV. =  15.9 DEGREES          
REMARK 500    LEU K 134   CA  -  CB  -  CG  ANGL. DEV. =  16.2 DEGREES          
REMARK 500    ASP K 351   CB  -  CG  -  OD1 ANGL. DEV. =   8.1 DEGREES          
REMARK 500    LEU K 376   CA  -  CB  -  CG  ANGL. DEV. =  14.2 DEGREES          
REMARK 500    PRO N  29   N   -  CA  -  CB  ANGL. DEV. =   7.2 DEGREES          
REMARK 500    PRO N  56   N   -  CA  -  CB  ANGL. DEV. =   8.9 DEGREES          
REMARK 500    ALA N  63   N   -  CA  -  C   ANGL. DEV. =  17.2 DEGREES          
REMARK 500    PRO N 219   N   -  CA  -  CB  ANGL. DEV. =   7.3 DEGREES          
REMARK 500    ARG N 330   NE  -  CZ  -  NH1 ANGL. DEV. =   4.1 DEGREES          
REMARK 500    ARG N 330   NE  -  CZ  -  NH2 ANGL. DEV. =  -6.8 DEGREES          
REMARK 500    ASP N 395   N   -  CA  -  C   ANGL. DEV. =  17.6 DEGREES          
REMARK 500    PRO N 477   N   -  CA  -  CB  ANGL. DEV. =   8.6 DEGREES          
REMARK 500    PRO N 489   N   -  CA  -  CB  ANGL. DEV. =   8.7 DEGREES          
REMARK 500    ARG N 496   N   -  CA  -  C   ANGL. DEV. =  16.8 DEGREES          
REMARK 500    ASP O 117   CB  -  CG  -  OD1 ANGL. DEV. =  -7.0 DEGREES          
REMARK 500    ASP O 117   CB  -  CG  -  OD2 ANGL. DEV. =   6.3 DEGREES          
REMARK 500    LEU P 358   CA  -  CB  -  CG  ANGL. DEV. =  17.2 DEGREES          
REMARK 500    LEU P 358   CB  -  CG  -  CD1 ANGL. DEV. = -14.4 DEGREES          
REMARK 500    PRO Q 141   N   -  CA  -  CB  ANGL. DEV. =   9.9 DEGREES          
REMARK 500    PRO Q 158   N   -  CA  -  CB  ANGL. DEV. =   7.7 DEGREES          
REMARK 500    PRO Q 477   N   -  CA  -  CB  ANGL. DEV. =   8.1 DEGREES          
REMARK 500    LEU R 118   CA  -  CB  -  CG  ANGL. DEV. =  15.8 DEGREES          
REMARK 500    MET S  38   CB  -  CA  -  C   ANGL. DEV. = -14.1 DEGREES          
REMARK 500    MET S  38   CA  -  CB  -  CG  ANGL. DEV. =  13.4 DEGREES          
REMARK 500    LEU S  45   CB  -  CG  -  CD2 ANGL. DEV. = -13.6 DEGREES          
REMARK 500    ARG S  60   NE  -  CZ  -  NH1 ANGL. DEV. =   4.6 DEGREES          
REMARK 500    ARG S  60   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.5 DEGREES          
REMARK 500    PRO S 135   C   -  N   -  CD  ANGL. DEV. = -13.0 DEGREES          
REMARK 500    PRO S 222   N   -  CA  -  CB  ANGL. DEV. =   7.7 DEGREES          
REMARK 500    PRO S 290   N   -  CA  -  CB  ANGL. DEV. =   7.7 DEGREES          
REMARK 500    LEU Y  70   CB  -  CG  -  CD1 ANGL. DEV. =  11.7 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      52 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A  33       -7.52     74.95                                   
REMARK 500    GLN A  38       69.19   -106.69                                   
REMARK 500    LEU A  57     -127.52     58.56                                   
REMARK 500    VAL A  87     -106.43     42.46                                   
REMARK 500    ASP A 120      -16.49     70.55                                   
REMARK 500    GLN A 125      -64.32   -137.01                                   
REMARK 500    SER A 254      105.22    -55.03                                   
REMARK 500    VAL A 274      -35.29    114.26                                   
REMARK 500    LYS A 275     -137.48     60.50                                   
REMARK 500    GLU A 279      118.73    -38.96                                   
REMARK 500    ASP A 486       41.47     71.71                                   
REMARK 500    ASP A 589       65.09     37.54                                   
REMARK 500    ASN A 593      -17.65     91.50                                   
REMARK 500    ALA A 613      -84.50   -108.92                                   
REMARK 500    THR A 614      -27.21     76.33                                   
REMARK 500    PRO A 630     -106.18    -68.63                                   
REMARK 500    LYS A 631      -39.63   -130.94                                   
REMARK 500    SER A 652     -101.00     54.40                                   
REMARK 500    TYR A 653      -22.91     80.14                                   
REMARK 500    MET A 668      -67.27   -108.25                                   
REMARK 500    THR A 777      -29.42     71.85                                   
REMARK 500    GLU A 781      -25.09     61.94                                   
REMARK 500    MET A 857      -84.32     77.85                                   
REMARK 500    TYR A 860      145.26    104.87                                   
REMARK 500    ARG A 980       71.91   -154.95                                   
REMARK 500    ASP A1014       -2.13     70.66                                   
REMARK 500    GLU A1030     -111.41     66.44                                   
REMARK 500    HIS A1045      158.87     66.36                                   
REMARK 500    PRO A1055       69.19    -55.77                                   
REMARK 500    THR A1088       57.08   -105.90                                   
REMARK 500    GLU A1098      154.45    -49.93                                   
REMARK 500    PRO A1099      -83.62    -64.90                                   
REMARK 500    LEU A1100      -68.47   -129.92                                   
REMARK 500    ILE A1125      162.59     67.94                                   
REMARK 500    THR A1132      -19.45     94.56                                   
REMARK 500    LYS A1164       -3.27     53.25                                   
REMARK 500    LEU A1217       65.84     33.21                                   
REMARK 500    MET A1220       74.01     57.55                                   
REMARK 500    THR A1239      158.55    169.03                                   
REMARK 500    GLU A1284     -128.91     49.45                                   
REMARK 500    TYR A1287        7.96     82.20                                   
REMARK 500    CYS A1288       51.10   -105.64                                   
REMARK 500    LEU A1307       75.79     17.39                                   
REMARK 500    ILE A1314     -113.54     39.14                                   
REMARK 500    GLN A1351      -62.75   -124.23                                   
REMARK 500    ASP A1356     -174.71     54.33                                   
REMARK 500    ILE A1358      147.39     66.42                                   
REMARK 500    ASN A1380       98.95    -62.69                                   
REMARK 500    ASN A1503      -14.26     90.72                                   
REMARK 500    THR A1546     -138.52     45.98                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     390 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 LEU A 1191     ASN A 1192                  149.42                    
REMARK 500 GLY I  658     ARG I  659                 -145.82                    
REMARK 500 PHE I  727     ARG I  728                  149.62                    
REMARK 500 ILE J  220     PRO J  221                 -130.61                    
REMARK 500 ARG N   62     ALA N   63                  139.56                    
REMARK 500 GLU N   77     VAL N   78                  144.24                    
REMARK 500 PHE N  162     PHE N  163                   38.45                    
REMARK 500 SER N  164     THR N  165                  -31.09                    
REMARK 500 GLU N  280     TYR N  281                   37.57                    
REMARK 500 TYR N  281     GLU N  282                 -141.72                    
REMARK 500 PHE N  351     PRO N  352                  141.08                    
REMARK 500 PRO N  352     ASP N  353                 -146.93                    
REMARK 500 ASP N  353     SER N  354                 -147.03                    
REMARK 500 ARG N  367     THR N  368                 -142.50                    
REMARK 500 ASP N  369     GLN N  370                 -149.73                    
REMARK 500 LEU N  387     HIS N  388                 -135.65                    
REMARK 500 GLY N  390     VAL N  391                  149.30                    
REMARK 500 CYS N  394     ASP N  395                  110.88                    
REMARK 500 ASP N  395     ILE N  396                  145.78                    
REMARK 500 VAL N  485     ASP N  486                  149.77                    
REMARK 500 LYS S  235     LYS S  236                  149.27                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-4037   RELATED DB: EMDB                              
DBREF  5LCW A    1  1944  UNP    Q9H1A4   APC1_HUMAN       1   1944             
DBREF  5LCW B    1    84  UNP    Q9NYG5   APC11_HUMAN      1     84             
DBREF  5LCW C    1   597  UNP    Q9UJX2   CDC23_HUMAN      1    597             
DBREF  5LCW D    1   121  UNP    P60006   APC15_HUMAN      1    121             
DBREF  5LCW E    1   110  UNP    Q96DE5   APC16_HUMAN      1    110             
DBREF  5LCW F    1   824  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  5LCW G    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  5LCW H    1   824  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  5LCW I    1   808  UNP    Q9UJX5   APC4_HUMAN       1    808             
DBREF  5LCW J    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  5LCW K    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  5LCW L    1   184  UNP    Q9UM13   APC10_HUMAN      1    185             
DBREF  5LCW M    1    74  UNP    Q9BS18   APC13_HUMAN      1     74             
DBREF  5LCW N   14   822  UNP    Q9UJX6   ANC2_HUMAN       1    822             
DBREF  5LCW O    1   755  UNP    Q9UJX4   APC5_HUMAN       1    755             
DBREF  5LCW P    1   597  UNP    Q9UJX2   CDC23_HUMAN      1    597             
DBREF  5LCW Q  126   499  UNP    Q12834   CDC20_HUMAN    126    499             
DBREF  5LCW R    1   499  UNP    Q12834   CDC20_HUMAN      1    499             
DBREF  5LCW S    1   310  UNP    O60566   BUB1B_HUMAN      1    310             
DBREF  5LCW S  529   560  UNP    O60566   BUB1B_HUMAN    529    560             
DBREF  5LCW W    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  5LCW X    1   599  UNP    Q9UJX3   APC7_HUMAN       1    599             
DBREF  5LCW Y    1   599  UNP    Q9UJX3   APC7_HUMAN       1    599             
DBREF  5LCW Z    1   205  UNP    Q13257   MD2L1_HUMAN      1    205             
SEQADV 5LCW PHE A  356  UNP  Q9H1A4    PRO   356 CONFLICT                       
SEQRES   1 A 1944  MET SER ASN PHE TYR GLU GLU ARG THR THR MET ILE ALA          
SEQRES   2 A 1944  ALA ARG ASP LEU GLN GLU PHE VAL PRO PHE GLY ARG ASP          
SEQRES   3 A 1944  HIS CYS LYS HIS HIS PRO ASN ALA LEU ASN LEU GLN LEU          
SEQRES   4 A 1944  ARG GLN LEU GLN PRO ALA SER GLU LEU TRP SER SER ASP          
SEQRES   5 A 1944  GLY ALA ALA GLY LEU VAL GLY SER LEU GLN GLU VAL THR          
SEQRES   6 A 1944  ILE HIS GLU LYS GLN LYS GLU SER TRP GLN LEU ARG LYS          
SEQRES   7 A 1944  GLY VAL SER GLU ILE GLY GLU ASP VAL ASP TYR ASP GLU          
SEQRES   8 A 1944  GLU LEU TYR VAL ALA GLY ASN MET VAL ILE TRP SER LYS          
SEQRES   9 A 1944  GLY SER LYS SER GLN ALA LEU ALA VAL TYR LYS ALA PHE          
SEQRES  10 A 1944  THR VAL ASP SER PRO VAL GLN GLN ALA LEU TRP CYS ASP          
SEQRES  11 A 1944  PHE ILE ILE SER GLN ASP LYS SER GLU LYS ALA TYR SER          
SEQRES  12 A 1944  SER ASN GLU VAL GLU LYS CYS ILE CYS ILE LEU GLN SER          
SEQRES  13 A 1944  SER CYS ILE ASN MET HIS SER ILE GLU GLY LYS ASP TYR          
SEQRES  14 A 1944  ILE ALA SER LEU PRO PHE GLN VAL ALA ASN VAL TRP PRO          
SEQRES  15 A 1944  THR LYS TYR GLY LEU LEU PHE GLU ARG SER ALA SER SER          
SEQRES  16 A 1944  HIS GLU VAL PRO PRO GLY SER PRO ARG GLU PRO LEU PRO          
SEQRES  17 A 1944  THR MET PHE SER MET LEU HIS PRO LEU ASP GLU ILE THR          
SEQRES  18 A 1944  PRO LEU VAL CYS LYS SER GLY SER LEU PHE GLY SER SER          
SEQRES  19 A 1944  ARG VAL GLN TYR VAL VAL ASP HIS ALA MET LYS ILE VAL          
SEQRES  20 A 1944  PHE LEU ASN THR ASP PRO SER ILE VAL MET THR TYR ASP          
SEQRES  21 A 1944  ALA VAL GLN ASN VAL HIS SER VAL TRP THR LEU ARG ARG          
SEQRES  22 A 1944  VAL LYS SER GLU GLU GLU ASN VAL VAL LEU LYS PHE SER          
SEQRES  23 A 1944  GLU GLN GLY GLY THR PRO GLN ASN VAL ALA THR SER SER          
SEQRES  24 A 1944  SER LEU THR ALA HIS LEU ARG SER LEU SER LYS GLY ASP          
SEQRES  25 A 1944  SER PRO VAL THR SER PRO PHE GLN ASN TYR SER SER ILE          
SEQRES  26 A 1944  HIS SER GLN SER ARG SER THR SER SER PRO SER LEU HIS          
SEQRES  27 A 1944  SER ARG SER PRO SER ILE SER ASN MET ALA ALA LEU SER          
SEQRES  28 A 1944  ARG ALA HIS SER PHE ALA LEU GLY VAL HIS SER PHE SER          
SEQRES  29 A 1944  GLY VAL GLN ARG PHE ASN ILE SER SER HIS ASN GLN SER          
SEQRES  30 A 1944  PRO LYS ARG HIS SER ILE SER HIS SER PRO ASN SER ASN          
SEQRES  31 A 1944  SER ASN GLY SER PHE LEU ALA PRO GLU THR GLU PRO ILE          
SEQRES  32 A 1944  VAL PRO GLU LEU CYS ILE ASP HIS LEU TRP THR GLU THR          
SEQRES  33 A 1944  ILE THR ASN ILE ARG GLU LYS ASN SER GLN ALA SER LYS          
SEQRES  34 A 1944  VAL PHE ILE THR SER ASP LEU CYS GLY GLN LYS PHE LEU          
SEQRES  35 A 1944  CYS PHE LEU VAL GLU SER GLN LEU GLN LEU ARG CYS VAL          
SEQRES  36 A 1944  LYS PHE GLN GLU SER ASN ASP LYS THR GLN LEU ILE PHE          
SEQRES  37 A 1944  GLY SER VAL THR ASN ILE PRO ALA LYS ASP ALA ALA PRO          
SEQRES  38 A 1944  VAL GLU LYS ILE ASP THR MET LEU VAL LEU GLU GLY SER          
SEQRES  39 A 1944  GLY ASN LEU VAL LEU TYR THR GLY VAL VAL ARG VAL GLY          
SEQRES  40 A 1944  LYS VAL PHE ILE PRO GLY LEU PRO ALA PRO SER LEU THR          
SEQRES  41 A 1944  MET SER ASN THR MET PRO ARG PRO SER THR PRO LEU ASP          
SEQRES  42 A 1944  GLY VAL SER THR PRO LYS PRO LEU SER LYS LEU LEU GLY          
SEQRES  43 A 1944  SER LEU ASP GLU VAL VAL LEU LEU SER PRO VAL PRO GLU          
SEQRES  44 A 1944  LEU ARG ASP SER SER LYS LEU HIS ASP SER LEU TYR ASN          
SEQRES  45 A 1944  GLU ASP CYS THR PHE GLN GLN LEU GLY THR TYR ILE HIS          
SEQRES  46 A 1944  SER ILE ARG ASP PRO VAL HIS ASN ARG VAL THR LEU GLU          
SEQRES  47 A 1944  LEU SER ASN GLY SER MET VAL ARG ILE THR ILE PRO GLU          
SEQRES  48 A 1944  ILE ALA THR SER GLU LEU VAL GLN THR CYS LEU GLN ALA          
SEQRES  49 A 1944  ILE LYS PHE ILE LEU PRO LYS GLU ILE ALA VAL GLN MET          
SEQRES  50 A 1944  LEU VAL LYS TRP TYR ASN VAL HIS SER ALA PRO GLY GLY          
SEQRES  51 A 1944  PRO SER TYR HIS SER GLU TRP ASN LEU PHE VAL THR CYS          
SEQRES  52 A 1944  LEU MET ASN MET MET GLY TYR ASN THR ASP ARG LEU ALA          
SEQRES  53 A 1944  TRP THR ARG ASN PHE ASP PHE GLU GLY SER LEU SER PRO          
SEQRES  54 A 1944  VAL ILE ALA PRO LYS LYS ALA ARG PRO SER GLU THR GLY          
SEQRES  55 A 1944  SER ASP ASP ASP TRP GLU TYR LEU LEU ASN SER ASP TYR          
SEQRES  56 A 1944  HIS GLN ASN VAL GLU SER HIS LEU LEU ASN ARG SER LEU          
SEQRES  57 A 1944  CYS LEU SER PRO SER GLU ALA SER GLN MET LYS ASP GLU          
SEQRES  58 A 1944  ASP PHE SER GLN ASN LEU SER LEU ASP SER SER THR LEU          
SEQRES  59 A 1944  LEU PHE THR HIS ILE PRO ALA ILE PHE PHE VAL LEU HIS          
SEQRES  60 A 1944  LEU VAL TYR GLU GLU LEU LYS LEU ASN THR LEU MET GLY          
SEQRES  61 A 1944  GLU GLY ILE CYS SER LEU VAL GLU LEU LEU VAL GLN LEU          
SEQRES  62 A 1944  ALA ARG ASP LEU LYS LEU GLY PRO TYR VAL ASP HIS TYR          
SEQRES  63 A 1944  TYR ARG ASP TYR PRO THR LEU VAL ARG THR THR GLY GLN          
SEQRES  64 A 1944  VAL CYS THR ILE ASP PRO GLY GLN THR GLY PHE MET HIS          
SEQRES  65 A 1944  HIS PRO SER PHE PHE THR SER GLU PRO PRO SER ILE TYR          
SEQRES  66 A 1944  GLN TRP VAL SER SER CYS LEU LYS GLY GLU GLY MET PRO          
SEQRES  67 A 1944  PRO TYR PRO TYR LEU PRO GLY ILE CYS GLU ARG SER ARG          
SEQRES  68 A 1944  LEU VAL VAL LEU SER ILE ALA LEU TYR ILE LEU GLY ASP          
SEQRES  69 A 1944  GLU SER LEU VAL SER ASP GLU SER SER GLN TYR LEU THR          
SEQRES  70 A 1944  ARG ILE THR ILE ALA PRO GLN LYS LEU GLN VAL GLU GLN          
SEQRES  71 A 1944  GLU GLU ASN ARG PHE SER PHE ARG HIS SER THR SER VAL          
SEQRES  72 A 1944  SER SER LEU ALA GLU ARG LEU VAL VAL TRP MET THR ASN          
SEQRES  73 A 1944  VAL GLY PHE THR LEU ARG ASP LEU GLU THR LEU PRO PHE          
SEQRES  74 A 1944  GLY ILE ALA LEU PRO ILE ARG ASP ALA ILE TYR HIS CYS          
SEQRES  75 A 1944  ARG GLU GLN PRO ALA SER ASP TRP PRO GLU ALA VAL CYS          
SEQRES  76 A 1944  LEU LEU ILE GLY ARG GLN ASP LEU SER LYS GLN ALA CYS          
SEQRES  77 A 1944  GLU GLY ASN LEU PRO LYS GLY LYS SER VAL LEU SER SER          
SEQRES  78 A 1944  ASP VAL PRO SER GLY THR GLU THR GLU GLU GLU ASP ASP          
SEQRES  79 A 1944  GLY MET ASN ASP MET ASN HIS GLU VAL MET SER LEU ILE          
SEQRES  80 A 1944  TRP SER GLU ASP LEU ARG VAL GLN ASP VAL ARG ARG LEU          
SEQRES  81 A 1944  LEU GLN SER ALA HIS PRO VAL ARG VAL ASN VAL VAL GLN          
SEQRES  82 A 1944  TYR PRO GLU LEU SER ASP HIS GLU PHE ILE GLU GLU LYS          
SEQRES  83 A 1944  GLU ASN ARG LEU LEU GLN LEU CYS GLN ARG THR MET ALA          
SEQRES  84 A 1944  LEU PRO VAL GLY ARG GLY MET PHE THR LEU PHE SER TYR          
SEQRES  85 A 1944  HIS PRO VAL PRO THR GLU PRO LEU PRO ILE PRO LYS LEU          
SEQRES  86 A 1944  ASN LEU THR GLY ARG ALA PRO PRO ARG ASN THR THR VAL          
SEQRES  87 A 1944  ASP LEU ASN SER GLY ASN ILE ASP VAL PRO PRO ASN MET          
SEQRES  88 A 1944  THR SER TRP ALA SER PHE HIS ASN GLY VAL ALA ALA GLY          
SEQRES  89 A 1944  LEU LYS ILE ALA PRO ALA SER GLN ILE ASP SER ALA TRP          
SEQRES  90 A 1944  ILE VAL TYR ASN LYS PRO LYS HIS ALA GLU LEU ALA ASN          
SEQRES  91 A 1944  GLU TYR ALA GLY PHE LEU MET ALA LEU GLY LEU ASN GLY          
SEQRES  92 A 1944  HIS LEU THR LYS LEU ALA THR LEU ASN ILE HIS ASP TYR          
SEQRES  93 A 1944  LEU THR LYS GLY HIS GLU MET THR SER ILE GLY LEU LEU          
SEQRES  94 A 1944  LEU GLY VAL SER ALA ALA LYS LEU GLY THR MET ASP MET          
SEQRES  95 A 1944  SER ILE THR ARG LEU LEU SER ILE HIS ILE PRO ALA LEU          
SEQRES  96 A 1944  LEU PRO PRO THR SER THR GLU LEU ASP VAL PRO HIS ASN          
SEQRES  97 A 1944  VAL GLN VAL ALA ALA VAL VAL GLY ILE GLY LEU VAL TYR          
SEQRES  98 A 1944  GLN GLY THR ALA HIS ARG HIS THR ALA GLU VAL LEU LEU          
SEQRES  99 A 1944  ALA GLU ILE GLY ARG PRO PRO GLY PRO GLU MET GLU TYR          
SEQRES 100 A 1944  CYS THR ASP ARG GLU SER TYR SER LEU ALA ALA GLY LEU          
SEQRES 101 A 1944  ALA LEU GLY MET VAL CYS LEU GLY HIS GLY SER ASN LEU          
SEQRES 102 A 1944  ILE GLY MET SER ASP LEU ASN VAL PRO GLU GLN LEU TYR          
SEQRES 103 A 1944  GLN TYR MET VAL GLY GLY HIS ARG ARG PHE GLN THR GLY          
SEQRES 104 A 1944  MET HIS ARG GLU LYS HIS LYS SER PRO SER TYR GLN ILE          
SEQRES 105 A 1944  LYS GLU GLY ASP THR ILE ASN VAL ASP VAL THR CYS PRO          
SEQRES 106 A 1944  GLY ALA THR LEU ALA LEU ALA MET ILE TYR LEU LYS THR          
SEQRES 107 A 1944  ASN ASN ARG SER ILE ALA ASP TRP LEU ARG ALA PRO ASP          
SEQRES 108 A 1944  THR MET TYR LEU LEU ASP PHE VAL LYS PRO GLU PHE LEU          
SEQRES 109 A 1944  LEU LEU ARG THR LEU ALA ARG CYS LEU ILE LEU TRP ASP          
SEQRES 110 A 1944  ASP ILE LEU PRO ASN SER LYS TRP VAL ASP SER ASN VAL          
SEQRES 111 A 1944  PRO GLN ILE ILE ARG GLU ASN SER ILE SER LEU SER GLU          
SEQRES 112 A 1944  ILE GLU LEU PRO CYS SER GLU ASP LEU ASN LEU GLU THR          
SEQRES 113 A 1944  LEU SER GLN ALA HIS VAL TYR ILE ILE ALA GLY ALA CYS          
SEQRES 114 A 1944  LEU SER LEU GLY PHE ARG PHE ALA GLY SER GLU ASN LEU          
SEQRES 115 A 1944  SER ALA PHE ASN CYS LEU HIS LYS PHE ALA LYS ASP PHE          
SEQRES 116 A 1944  MET THR TYR LEU SER ALA PRO ASN ALA SER VAL THR GLY          
SEQRES 117 A 1944  PRO HIS ASN LEU GLU THR CYS LEU SER VAL VAL LEU LEU          
SEQRES 118 A 1944  SER LEU ALA MET VAL MET ALA GLY SER GLY ASN LEU LYS          
SEQRES 119 A 1944  VAL LEU GLN LEU CYS ARG PHE LEU HIS MET LYS THR GLY          
SEQRES 120 A 1944  GLY GLU MET ASN TYR GLY PHE HIS LEU ALA HIS HIS MET          
SEQRES 121 A 1944  ALA LEU GLY LEU LEU PHE LEU GLY GLY GLY ARG TYR SER          
SEQRES 122 A 1944  LEU SER THR SER ASN SER SER ILE ALA ALA LEU LEU CYS          
SEQRES 123 A 1944  ALA LEU TYR PRO HIS PHE PRO ALA HIS SER THR ASP ASN          
SEQRES 124 A 1944  ARG TYR HIS LEU GLN ALA LEU ARG HIS LEU TYR VAL LEU          
SEQRES 125 A 1944  ALA ALA GLU PRO ARG LEU LEU VAL PRO VAL ASP VAL ASP          
SEQRES 126 A 1944  THR ASN THR PRO CYS TYR ALA LEU LEU GLU VAL THR TYR          
SEQRES 127 A 1944  LYS GLY THR GLN TRP TYR GLU GLN THR LYS GLU GLU LEU          
SEQRES 128 A 1944  MET ALA PRO THR LEU LEU PRO GLU LEU HIS LEU LEU LYS          
SEQRES 129 A 1944  GLN ILE LYS VAL LYS GLY PRO ARG TYR TRP GLU LEU LEU          
SEQRES 130 A 1944  ILE ASP LEU SER LYS GLY THR GLN HIS LEU LYS SER ILE          
SEQRES 131 A 1944  LEU SER LYS ASP GLY VAL LEU TYR VAL LYS LEU ARG ALA          
SEQRES 132 A 1944  GLY GLN LEU SER TYR LYS GLU ASP PRO MET GLY TRP GLN          
SEQRES 133 A 1944  SER LEU LEU ALA GLN THR VAL ALA ASN ARG ASN SER GLU          
SEQRES 134 A 1944  ALA ARG ALA PHE LYS PRO GLU THR ILE SER ALA PHE THR          
SEQRES 135 A 1944  SER ASP PRO ALA LEU LEU SER PHE ALA GLU TYR PHE CYS          
SEQRES 136 A 1944  LYS PRO THR VAL ASN MET GLY GLN LYS GLN GLU ILE LEU          
SEQRES 137 A 1944  ASP LEU PHE SER SER VAL LEU TYR GLU CYS VAL THR GLN          
SEQRES 138 A 1944  GLU THR PRO GLU MET LEU PRO ALA TYR ILE ALA MET ASP          
SEQRES 139 A 1944  GLN ALA ILE ARG ARG LEU GLY ARG ARG GLU MET SER GLU          
SEQRES 140 A 1944  THR SER GLU LEU TRP GLN ILE LYS LEU VAL LEU GLU PHE          
SEQRES 141 A 1944  PHE SER SER ARG SER HIS GLN GLU ARG LEU GLN ASN HIS          
SEQRES 142 A 1944  PRO LYS ARG GLY LEU PHE MET ASN SER GLU PHE LEU PRO          
SEQRES 143 A 1944  VAL VAL LYS CYS THR ILE ASP ASN THR LEU ASP GLN TRP          
SEQRES 144 A 1944  LEU GLN VAL GLY GLY ASP MET CYS VAL HIS ALA TYR LEU          
SEQRES 145 A 1944  SER GLY GLN PRO LEU GLU GLU SER GLN LEU SER MET LEU          
SEQRES 146 A 1944  ALA CYS PHE LEU VAL TYR HIS SER VAL PRO ALA PRO GLN          
SEQRES 147 A 1944  HIS LEU PRO PRO ILE GLY LEU GLU GLY SER THR SER PHE          
SEQRES 148 A 1944  ALA GLU LEU LEU PHE LYS PHE LYS GLN LEU LYS MET PRO          
SEQRES 149 A 1944  VAL ARG ALA LEU LEU ARG LEU ALA PRO LEU LEU LEU GLY          
SEQRES 150 A 1944  ASN PRO GLN PRO MET VAL MET                                  
SEQRES   1 B   84  MET LYS VAL LYS ILE LYS CYS TRP ASN GLY VAL ALA THR          
SEQRES   2 B   84  TRP LEU TRP VAL ALA ASN ASP GLU ASN CYS GLY ILE CYS          
SEQRES   3 B   84  ARG MET ALA PHE ASN GLY CYS CYS PRO ASP CYS LYS VAL          
SEQRES   4 B   84  PRO GLY ASP ASP CYS PRO LEU VAL TRP GLY GLN CYS SER          
SEQRES   5 B   84  HIS CYS PHE HIS MET HIS CYS ILE LEU LYS TRP LEU HIS          
SEQRES   6 B   84  ALA GLN GLN VAL GLN GLN HIS CYS PRO MET CYS ARG GLN          
SEQRES   7 B   84  GLU TRP LYS PHE LYS GLU                                      
SEQRES   1 C  597  MET ALA ALA SER THR SER MET VAL PRO VAL ALA VAL THR          
SEQRES   2 C  597  ALA ALA VAL ALA PRO VAL LEU SER ILE ASN SER ASP PHE          
SEQRES   3 C  597  SER ASP LEU ARG GLU ILE LYS LYS GLN LEU LEU LEU ILE          
SEQRES   4 C  597  ALA GLY LEU THR ARG GLU ARG GLY LEU LEU HIS SER SER          
SEQRES   5 C  597  LYS TRP SER ALA GLU LEU ALA PHE SER LEU PRO ALA LEU          
SEQRES   6 C  597  PRO LEU ALA GLU LEU GLN PRO PRO PRO PRO ILE THR GLU          
SEQRES   7 C  597  GLU ASP ALA GLN ASP MET ASP ALA TYR THR LEU ALA LYS          
SEQRES   8 C  597  ALA TYR PHE ASP VAL LYS GLU TYR ASP ARG ALA ALA HIS          
SEQRES   9 C  597  PHE LEU HIS GLY CYS ASN SER LYS LYS ALA TYR PHE LEU          
SEQRES  10 C  597  TYR MET TYR SER ARG TYR LEU SER GLY GLU LYS LYS LYS          
SEQRES  11 C  597  ASP ASP GLU THR VAL ASP SER LEU GLY PRO LEU GLU LYS          
SEQRES  12 C  597  GLY GLN VAL LYS ASN GLU ALA LEU ARG GLU LEU ARG VAL          
SEQRES  13 C  597  GLU LEU SER LYS LYS HIS GLN ALA ARG GLU LEU ASP GLY          
SEQRES  14 C  597  PHE GLY LEU TYR LEU TYR GLY VAL VAL LEU ARG LYS LEU          
SEQRES  15 C  597  ASP LEU VAL LYS GLU ALA ILE ASP VAL PHE VAL GLU ALA          
SEQRES  16 C  597  THR HIS VAL LEU PRO LEU HIS TRP GLY ALA TRP LEU GLU          
SEQRES  17 C  597  LEU CYS ASN LEU ILE THR ASP LYS GLU MET LEU LYS PHE          
SEQRES  18 C  597  LEU SER LEU PRO ASP THR TRP MET LYS GLU PHE PHE LEU          
SEQRES  19 C  597  ALA HIS ILE TYR THR GLU LEU GLN LEU ILE GLU GLU ALA          
SEQRES  20 C  597  LEU GLN LYS TYR GLN ASN LEU ILE ASP VAL GLY PHE SER          
SEQRES  21 C  597  LYS SER SER TYR ILE VAL SER GLN ILE ALA VAL ALA TYR          
SEQRES  22 C  597  HIS ASN ILE ARG ASP ILE ASP LYS ALA LEU SER ILE PHE          
SEQRES  23 C  597  ASN GLU LEU ARG LYS GLN ASP PRO TYR ARG ILE GLU ASN          
SEQRES  24 C  597  MET ASP THR PHE SER ASN LEU LEU TYR VAL ARG SER MET          
SEQRES  25 C  597  LYS SER GLU LEU SER TYR LEU ALA HIS ASN LEU CYS GLU          
SEQRES  26 C  597  ILE ASP LYS TYR ARG VAL GLU THR CYS CYS VAL ILE GLY          
SEQRES  27 C  597  ASN TYR TYR SER LEU ARG SER GLN HIS GLU LYS ALA ALA          
SEQRES  28 C  597  LEU TYR PHE GLN ARG ALA LEU LYS LEU ASN PRO ARG TYR          
SEQRES  29 C  597  LEU GLY ALA TRP THR LEU MET GLY HIS GLU TYR MET GLU          
SEQRES  30 C  597  MET LYS ASN THR SER ALA ALA ILE GLN ALA TYR ARG HIS          
SEQRES  31 C  597  ALA ILE GLU VAL ASN LYS ARG ASP TYR ARG ALA TRP TYR          
SEQRES  32 C  597  GLY LEU GLY GLN THR TYR GLU ILE LEU LYS MET PRO PHE          
SEQRES  33 C  597  TYR CYS LEU TYR TYR TYR ARG ARG ALA HIS GLN LEU ARG          
SEQRES  34 C  597  PRO ASN ASP SER ARG MET LEU VAL ALA LEU GLY GLU CYS          
SEQRES  35 C  597  TYR GLU LYS LEU ASN GLN LEU VAL GLU ALA LYS LYS CYS          
SEQRES  36 C  597  TYR TRP ARG ALA TYR ALA VAL GLY ASP VAL GLU LYS MET          
SEQRES  37 C  597  ALA LEU VAL LYS LEU ALA LYS LEU HIS GLU GLN LEU THR          
SEQRES  38 C  597  GLU SER GLU GLN ALA ALA GLN CYS TYR ILE LYS TYR ILE          
SEQRES  39 C  597  GLN ASP ILE TYR SER CYS GLY GLU ILE VAL GLU HIS LEU          
SEQRES  40 C  597  GLU GLU SER THR ALA PHE ARG TYR LEU ALA GLN TYR TYR          
SEQRES  41 C  597  PHE LYS CYS LYS LEU TRP ASP GLU ALA SER THR CYS ALA          
SEQRES  42 C  597  GLN LYS CYS CYS ALA PHE ASN ASP THR ARG GLU GLU GLY          
SEQRES  43 C  597  LYS ALA LEU LEU ARG GLN ILE LEU GLN LEU ARG ASN GLN          
SEQRES  44 C  597  GLY GLU THR PRO THR THR GLU VAL PRO ALA PRO PHE PHE          
SEQRES  45 C  597  LEU PRO ALA SER LEU SER ALA ASN ASN THR PRO THR ARG          
SEQRES  46 C  597  ARG VAL SER PRO LEU ASN LEU SER SER VAL THR PRO              
SEQRES   1 D  121  MET SER THR LEU PHE PRO SER LEU PHE PRO ARG VAL THR          
SEQRES   2 D  121  GLU THR LEU TRP PHE ASN LEU ASP ARG PRO CYS VAL GLU          
SEQRES   3 D  121  GLU THR GLU LEU GLN GLN GLN GLU GLN GLN HIS GLN ALA          
SEQRES   4 D  121  TRP LEU GLN SER ILE ALA GLU LYS ASP ASN ASN LEU VAL          
SEQRES   5 D  121  PRO ILE GLY LYS PRO ALA SER GLU HIS TYR ASP ASP GLU          
SEQRES   6 D  121  GLU GLU GLU ASP ASP GLU ASP ASP GLU ASP SER GLU GLU          
SEQRES   7 D  121  ASP SER GLU ASP ASP GLU ASP MET GLN ASP MET ASP GLU          
SEQRES   8 D  121  MET ASN ASP TYR ASN GLU SER PRO ASP ASP GLY GLU VAL          
SEQRES   9 D  121  ASN GLU VAL ASP MET GLU GLY ASN GLU GLN ASP GLN ASP          
SEQRES  10 D  121  GLN TRP MET ILE                                              
SEQRES   1 E  110  MET ALA ALA SER SER SER SER SER SER ALA GLY GLY VAL          
SEQRES   2 E  110  SER GLY SER SER VAL THR GLY SER GLY PHE SER VAL SER          
SEQRES   3 E  110  ASP LEU ALA PRO PRO ARG LYS ALA LEU PHE THR TYR PRO          
SEQRES   4 E  110  LYS GLY ALA GLY GLU MET LEU GLU ASP GLY SER GLU ARG          
SEQRES   5 E  110  PHE LEU CYS GLU SER VAL PHE SER TYR GLN VAL ALA SER          
SEQRES   6 E  110  THR LEU LYS GLN VAL LYS HIS ASP GLN GLN VAL ALA ARG          
SEQRES   7 E  110  MET GLU LYS LEU ALA GLY LEU VAL GLU GLU LEU GLU ALA          
SEQRES   8 E  110  ASP GLU TRP ARG PHE LYS PRO ILE GLU GLN LEU LEU GLY          
SEQRES   9 E  110  PHE THR PRO SER SER GLY                                      
SEQRES   1 F  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 F  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 F  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 F  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 F  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 F  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 F  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 F  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 F  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 F  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 F  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 F  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 F  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 F  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 F  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 F  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 F  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 F  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 F  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 F  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 F  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 F  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 F  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 F  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 F  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 F  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 F  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 F  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 F  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 F  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 F  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO LYS          
SEQRES  32 F  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 F  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 F  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 F  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 F  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 F  824  MET GLY LYS GLY TYR LEU ALA LEU CYS SER TYR ASN CYS          
SEQRES  38 F  824  LYS GLU ALA ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 F  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 F  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 F  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 F  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 F  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 F  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 F  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 F  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 F  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 F  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 F  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 F  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 F  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 F  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 F  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 F  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 F  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 F  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 F  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 F  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 F  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 F  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 F  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 F  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 F  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 F  824  GLU SER ASP GLU PHE                                          
SEQRES   1 G   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 G   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 G   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 G   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 G   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 G   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 G   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 H  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 H  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 H  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 H  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 H  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 H  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 H  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 H  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 H  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 H  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 H  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 H  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 H  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 H  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 H  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 H  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 H  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 H  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 H  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 H  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 H  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 H  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 H  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 H  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 H  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 H  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 H  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 H  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 H  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 H  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 H  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO LYS          
SEQRES  32 H  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 H  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 H  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 H  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 H  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 H  824  MET GLY LYS GLY TYR LEU ALA LEU CYS SER TYR ASN CYS          
SEQRES  38 H  824  LYS GLU ALA ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 H  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 H  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 H  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 H  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 H  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 H  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 H  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 H  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 H  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 H  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 H  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 H  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 H  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 H  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 H  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 H  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 H  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 H  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 H  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 H  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 H  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 H  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 H  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 H  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 H  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 H  824  GLU SER ASP GLU PHE                                          
SEQRES   1 I  808  MET LEU ARG PHE PRO THR CYS PHE PRO SER PHE ARG VAL          
SEQRES   2 I  808  VAL GLY GLU LYS GLN LEU PRO GLN GLU ILE ILE PHE LEU          
SEQRES   3 I  808  VAL TRP SER PRO LYS ARG ASP LEU ILE ALA LEU ALA ASN          
SEQRES   4 I  808  THR ALA GLY GLU VAL LEU LEU HIS ARG LEU ALA SER PHE          
SEQRES   5 I  808  HIS ARG VAL TRP SER PHE PRO PRO ASN GLU ASN THR GLY          
SEQRES   6 I  808  LYS GLU VAL THR CYS LEU ALA TRP ARG PRO ASP GLY LYS          
SEQRES   7 I  808  LEU LEU ALA PHE ALA LEU ALA ASP THR LYS LYS ILE VAL          
SEQRES   8 I  808  LEU CYS ASP VAL GLU LYS PRO GLU SER LEU HIS SER PHE          
SEQRES   9 I  808  SER VAL GLU ALA PRO VAL SER CYS MET HIS TRP MET GLU          
SEQRES  10 I  808  VAL THR VAL GLU SER SER VAL LEU THR SER PHE TYR ASN          
SEQRES  11 I  808  ALA GLU ASP GLU SER ASN LEU LEU LEU PRO LYS LEU PRO          
SEQRES  12 I  808  THR LEU PRO LYS ASN TYR SER ASN THR SER LYS ILE PHE          
SEQRES  13 I  808  SER GLU GLU ASN SER ASP GLU ILE ILE LYS LEU LEU GLY          
SEQRES  14 I  808  ASP VAL ARG LEU ASN ILE LEU VAL LEU GLY GLY SER SER          
SEQRES  15 I  808  GLY PHE ILE GLU LEU TYR ALA TYR GLY MET PHE LYS ILE          
SEQRES  16 I  808  ALA ARG VAL THR GLY ILE ALA GLY THR CYS LEU ALA LEU          
SEQRES  17 I  808  CYS LEU SER SER ASP LEU LYS SER LEU SER VAL VAL THR          
SEQRES  18 I  808  GLU VAL SER THR ASN GLY ALA SER GLU VAL SER TYR PHE          
SEQRES  19 I  808  GLN LEU GLU THR ASN LEU LEU TYR SER PHE LEU PRO GLU          
SEQRES  20 I  808  VAL THR ARG MET ALA ARG LYS PHE THR HIS ILE SER ALA          
SEQRES  21 I  808  LEU LEU GLN TYR ILE ASN LEU SER LEU THR CYS MET CYS          
SEQRES  22 I  808  GLU ALA TRP GLU GLU ILE LEU MET GLN MET ASP SER ARG          
SEQRES  23 I  808  LEU THR LYS PHE VAL GLN GLU LYS ASN THR THR THR SER          
SEQRES  24 I  808  VAL GLN ASP GLU PHE MET HIS LEU LEU LEU TRP GLY LYS          
SEQRES  25 I  808  ALA SER ALA GLU LEU GLN THR LEU LEU MET ASN GLN LEU          
SEQRES  26 I  808  THR VAL LYS GLY LEU LYS LYS LEU GLY GLN SER ILE GLU          
SEQRES  27 I  808  SER SER TYR SER SER ILE GLN LYS LEU VAL ILE SER HIS          
SEQRES  28 I  808  LEU GLN SER GLY SER GLU SER LEU LEU TYR HIS LEU SER          
SEQRES  29 I  808  GLU LEU LYS GLY MET ALA SER TRP LYS GLN LYS TYR GLU          
SEQRES  30 I  808  PRO LEU GLY LEU ASP ALA ALA GLY ILE GLU GLU ALA ILE          
SEQRES  31 I  808  THR ALA VAL GLY SER PHE ILE LEU LYS ALA ASN GLU LEU          
SEQRES  32 I  808  LEU GLN VAL ILE ASP SER SER MET LYS ASN PHE LYS ALA          
SEQRES  33 I  808  PHE PHE ARG TRP LEU TYR VAL ALA MET LEU ARG MET THR          
SEQRES  34 I  808  GLU ASP HIS VAL LEU PRO GLU LEU ASN LYS MET THR GLN          
SEQRES  35 I  808  LYS ASP ILE THR PHE VAL ALA GLU PHE LEU THR GLU HIS          
SEQRES  36 I  808  PHE ASN GLU ALA PRO ASP LEU TYR ASN ARG LYS GLY LYS          
SEQRES  37 I  808  TYR PHE ASN VAL GLU ARG VAL GLY GLN TYR LEU LYS ASP          
SEQRES  38 I  808  GLU ASP ASP ASP LEU VAL SER PRO PRO ASN THR GLU GLY          
SEQRES  39 I  808  ASN GLN TRP TYR ASP PHE LEU GLN ASN SER SER HIS LEU          
SEQRES  40 I  808  LYS GLU SER PRO LEU LEU PHE PRO TYR TYR PRO ARG LYS          
SEQRES  41 I  808  SER LEU HIS PHE VAL LYS ARG ARG MET GLU ASN ILE ILE          
SEQRES  42 I  808  ASP GLN CYS LEU GLN LYS PRO ALA ASP VAL ILE GLY LYS          
SEQRES  43 I  808  SER MET ASN GLN ALA ILE CYS ILE PRO LEU TYR ARG ASP          
SEQRES  44 I  808  THR ARG SER GLU ASP SER THR ARG ARG LEU PHE LYS PHE          
SEQRES  45 I  808  PRO PHE LEU TRP ASN ASN LYS THR SER ASN LEU HIS TYR          
SEQRES  46 I  808  LEU LEU PHE THR ILE LEU GLU ASP SER LEU TYR LYS MET          
SEQRES  47 I  808  CYS ILE LEU ARG ARG HIS THR ASP ILE SER GLN SER VAL          
SEQRES  48 I  808  SER ASN GLY LEU ILE ALA ILE LYS PHE GLY SER PHE THR          
SEQRES  49 I  808  TYR ALA THR THR GLU LYS VAL ARG ARG SER ILE TYR SER          
SEQRES  50 I  808  CYS LEU ASP ALA GLN PHE TYR ASP ASP GLU THR VAL THR          
SEQRES  51 I  808  VAL VAL LEU LYS ASP THR VAL GLY ARG GLU GLY ARG ASP          
SEQRES  52 I  808  ARG LEU LEU VAL GLN LEU PRO LEU SER LEU VAL TYR ASN          
SEQRES  53 I  808  SER GLU ASP SER ALA GLU TYR GLN PHE THR GLY THR TYR          
SEQRES  54 I  808  SER THR ARG LEU ASP GLU GLN CYS SER ALA ILE PRO THR          
SEQRES  55 I  808  ARG THR MET HIS PHE GLU LYS HIS TRP ARG LEU LEU GLU          
SEQRES  56 I  808  SER MET LYS ALA GLN TYR VAL ALA GLY ASN GLY PHE ARG          
SEQRES  57 I  808  LYS VAL SER CYS VAL LEU SER SER ASN LEU ARG HIS VAL          
SEQRES  58 I  808  ARG VAL PHE GLU MET ASP ILE ASP ASP GLU TRP GLU LEU          
SEQRES  59 I  808  ASP GLU SER SER ASP GLU GLU GLU GLU ALA SER ASN LYS          
SEQRES  60 I  808  PRO VAL LYS ILE LYS GLU GLU VAL LEU SER GLU SER GLU          
SEQRES  61 I  808  ALA GLU ASN GLN GLN ALA GLY ALA ALA ALA LEU ALA PRO          
SEQRES  62 I  808  GLU ILE VAL ILE LYS VAL GLU LYS LEU ASP PRO GLU LEU          
SEQRES  63 I  808  ASP SER                                                      
SEQRES   1 J  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 J  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 J  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 J  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 J  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 J  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 J  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 J  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 J  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 J  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 J  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 J  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 J  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 J  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 J  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 J  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 J  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 J  620  GLU SER VAL ASP GLY LEU GLN GLU ASN LEU ASP VAL VAL          
SEQRES  19 J  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 J  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 J  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 J  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 J  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 J  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 J  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 J  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 J  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 J  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 J  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 J  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 J  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 J  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 J  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 J  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 J  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 J  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 J  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 J  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 J  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 J  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 J  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 J  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 J  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 J  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 J  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 J  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 J  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 J  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 K  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 K  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 K  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 K  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 K  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 K  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 K  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 K  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 K  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 K  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 K  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 K  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 K  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 K  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 K  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 K  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 K  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 K  620  GLU SER VAL ASP GLY LEU GLN GLU ASN LEU ASP VAL VAL          
SEQRES  19 K  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 K  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 K  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 K  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 K  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 K  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 K  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 K  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 K  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 K  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 K  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 K  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 K  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 K  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 K  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 K  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 K  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 K  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 K  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 K  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 K  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 K  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 K  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 K  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 K  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 K  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 K  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 K  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 K  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 K  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 L  185  MET THR THR PRO ASN LYS THR PRO PRO GLY ALA ASP PRO          
SEQRES   2 L  185  LYS GLN LEU GLU ARG THR GLY THR VAL ARG GLU ILE GLY          
SEQRES   3 L  185  SER GLN ALA VAL TRP SER LEU SER SER CYS LYS PRO GLY          
SEQRES   4 L  185  PHE GLY VAL ASP GLN LEU ARG ASP ASP ASN LEU GLU THR          
SEQRES   5 L  185  TYR TRP GLN SER ASP GLY SER GLN PRO HIS LEU VAL ASN          
SEQRES   6 L  185  ILE GLN PHE ARG ARG LYS THR THR VAL LYS THR LEU CYS          
SEQRES   7 L  185  ILE TYR ALA ASP TYR LYS SER ASP GLU SER TYR THR PRO          
SEQRES   8 L  185  SER LYS ILE SER VAL ARG VAL GLY ASN ASN PHE HIS ASN          
SEQRES   9 L  185  LEU GLN GLU ILE ARG GLN LEU GLU LEU VAL GLU PRO SER          
SEQRES  10 L  185  GLY TRP ILE HIS VAL PRO LEU THR ASP ASN HIS LYS LYS          
SEQRES  11 L  185  PRO THR ARG THR PHE MET ILE GLN ILE ALA VAL LEU ALA          
SEQRES  12 L  185  ASN HIS GLN ASN GLY ARG ASP THR HIS MET ARG GLN ILE          
SEQRES  13 L  185  LYS ILE TYR THR PRO VAL GLU GLU SER SER ILE GLY LYS          
SEQRES  14 L  185  PHE PRO ARG CYS THR THR ILE ASP PHE MET MET TYR ARG          
SEQRES  15 L  185  SER ILE ARG                                                  
SEQRES   1 M   74  MET ASP SER GLU VAL GLN ARG ASP GLY ARG ILE LEU ASP          
SEQRES   2 M   74  LEU ILE ASP ASP ALA TRP ARG GLU ASP LYS LEU PRO TYR          
SEQRES   3 M   74  GLU ASP VAL ALA ILE PRO LEU ASN GLU LEU PRO GLU PRO          
SEQRES   4 M   74  GLU GLN ASP ASN GLY GLY THR THR GLU SER VAL LYS GLU          
SEQRES   5 M   74  GLN GLU MET LYS TRP THR ASP LEU ALA LEU GLN TYR LEU          
SEQRES   6 M   74  HIS GLU ASN VAL PRO PRO ILE GLY ASN                          
SEQRES   1 N  822  MET ALA ALA ALA VAL VAL VAL ALA GLU GLY ASP SER ASP          
SEQRES   2 N  822  SER ARG PRO GLY GLN GLU LEU LEU VAL ALA TRP ASN THR          
SEQRES   3 N  822  VAL SER THR GLY LEU VAL PRO PRO ALA ALA LEU GLY LEU          
SEQRES   4 N  822  VAL SER SER ARG THR SER GLY ALA VAL PRO PRO LYS GLU          
SEQRES   5 N  822  GLU GLU LEU ARG ALA ALA VAL GLU VAL LEU ARG GLY HIS          
SEQRES   6 N  822  GLY LEU HIS SER VAL LEU GLU GLU TRP PHE VAL GLU VAL          
SEQRES   7 N  822  LEU GLN ASN ASP LEU GLN ALA ASN ILE SER PRO GLU PHE          
SEQRES   8 N  822  TRP ASN ALA ILE SER GLN CYS GLU ASN SER ALA ASP GLU          
SEQRES   9 N  822  PRO GLN CYS LEU LEU LEU LEU LEU ASP ALA PHE GLY LEU          
SEQRES  10 N  822  LEU GLU SER ARG LEU ASP PRO TYR LEU ARG SER LEU GLU          
SEQRES  11 N  822  LEU LEU GLU LYS TRP THR ARG LEU GLY LEU LEU MET GLY          
SEQRES  12 N  822  THR GLY ALA GLN GLY LEU ARG GLU GLU VAL HIS THR MET          
SEQRES  13 N  822  LEU ARG GLY VAL LEU PHE PHE SER THR PRO ARG THR PHE          
SEQRES  14 N  822  GLN GLU MET ILE GLN ARG LEU TYR GLY CYS PHE LEU ARG          
SEQRES  15 N  822  VAL TYR MET GLN SER LYS ARG LYS GLY GLU GLY GLY THR          
SEQRES  16 N  822  ASP PRO GLU LEU GLU GLY GLU LEU ASP SER ARG TYR ALA          
SEQRES  17 N  822  ARG ARG ARG TYR TYR ARG LEU LEU GLN SER PRO LEU CYS          
SEQRES  18 N  822  ALA GLY CYS SER SER ASP LYS GLN GLN CYS TRP CYS ARG          
SEQRES  19 N  822  GLN ALA LEU GLU GLN PHE HIS GLN LEU SER GLN VAL LEU          
SEQRES  20 N  822  HIS ARG LEU SER LEU LEU GLU ARG VAL SER ALA GLU ALA          
SEQRES  21 N  822  VAL THR THR THR LEU HIS GLN VAL THR ARG GLU ARG MET          
SEQRES  22 N  822  GLU ASP ARG CYS ARG GLY GLU TYR GLU ARG SER PHE LEU          
SEQRES  23 N  822  ARG GLU PHE HIS LYS TRP ILE GLU ARG VAL VAL GLY TRP          
SEQRES  24 N  822  LEU GLY LYS VAL PHE LEU GLN ASP GLY PRO ALA ARG PRO          
SEQRES  25 N  822  ALA SER PRO GLU ALA GLY ASN THR LEU ARG ARG TRP ARG          
SEQRES  26 N  822  CYS HIS VAL GLN ARG PHE PHE TYR ARG ILE TYR ALA SER          
SEQRES  27 N  822  LEU ARG ILE GLU GLU LEU PHE SER ILE VAL ARG ASP PHE          
SEQRES  28 N  822  PRO ASP SER ARG PRO ALA ILE GLU ASP LEU LYS TYR CYS          
SEQRES  29 N  822  LEU GLU ARG THR ASP GLN ARG GLN GLN LEU LEU VAL SER          
SEQRES  30 N  822  LEU LYS ALA ALA LEU GLU THR ARG LEU LEU HIS PRO GLY          
SEQRES  31 N  822  VAL ASN THR CYS ASP ILE ILE THR LEU TYR ILE SER ALA          
SEQRES  32 N  822  ILE LYS ALA LEU ARG VAL LEU ASP PRO SER MET VAL ILE          
SEQRES  33 N  822  LEU GLU VAL ALA CYS GLU PRO ILE ARG ARG TYR LEU ARG          
SEQRES  34 N  822  THR ARG GLU ASP THR VAL ARG GLN ILE VAL ALA GLY LEU          
SEQRES  35 N  822  THR GLY ASP SER ASP GLY THR GLY ASP LEU ALA VAL GLU          
SEQRES  36 N  822  LEU SER LYS THR ASP PRO ALA SER LEU GLU THR GLY GLN          
SEQRES  37 N  822  ASP SER GLU ASP ASP SER GLY GLU PRO GLU ASP TRP VAL          
SEQRES  38 N  822  PRO ASP PRO VAL ASP ALA ASP PRO GLY LYS SER SER SER          
SEQRES  39 N  822  LYS ARG ARG SER SER ASP ILE ILE SER LEU LEU VAL SER          
SEQRES  40 N  822  ILE TYR GLY SER LYS ASP LEU PHE ILE ASN GLU TYR ARG          
SEQRES  41 N  822  SER LEU LEU ALA ASP ARG LEU LEU HIS GLN PHE SER PHE          
SEQRES  42 N  822  SER PRO GLU ARG GLU ILE ARG ASN VAL GLU LEU LEU LYS          
SEQRES  43 N  822  LEU ARG PHE GLY GLU ALA PRO MET HIS PHE CYS GLU VAL          
SEQRES  44 N  822  MET LEU LYS ASP MET ALA ASP SER ARG ARG ILE ASN ALA          
SEQRES  45 N  822  ASN ILE ARG GLU GLU ASP GLU LYS ARG PRO ALA GLU GLU          
SEQRES  46 N  822  GLN PRO PRO PHE GLY VAL TYR ALA VAL ILE LEU SER SER          
SEQRES  47 N  822  GLU PHE TRP PRO PRO PHE LYS ASP GLU LYS LEU GLU VAL          
SEQRES  48 N  822  PRO GLU ASP ILE ARG ALA ALA LEU GLU ALA TYR CYS LYS          
SEQRES  49 N  822  LYS TYR GLU GLN LEU LYS ALA MET ARG THR LEU SER TRP          
SEQRES  50 N  822  LYS HIS THR LEU GLY LEU VAL THR MET ASP VAL GLU LEU          
SEQRES  51 N  822  ALA ASP ARG THR LEU SER VAL ALA VAL THR PRO VAL GLN          
SEQRES  52 N  822  ALA VAL ILE LEU LEU TYR PHE GLN ASP GLN ALA SER TRP          
SEQRES  53 N  822  THR LEU GLU GLU LEU SER LYS ALA VAL LYS MET PRO VAL          
SEQRES  54 N  822  ALA LEU LEU ARG ARG ARG MET SER VAL TRP LEU GLN GLN          
SEQRES  55 N  822  GLY VAL LEU ARG GLU GLU PRO PRO GLY THR PHE SER VAL          
SEQRES  56 N  822  ILE GLU GLU GLU ARG PRO GLN ASP ARG ASP ASN MET VAL          
SEQRES  57 N  822  LEU ILE ASP SER ASP ASP GLU SER ASP SER GLY MET ALA          
SEQRES  58 N  822  SER GLN ALA ASP GLN LYS GLU GLU GLU LEU LEU LEU PHE          
SEQRES  59 N  822  TRP THR TYR ILE GLN ALA MET LEU THR ASN LEU GLU SER          
SEQRES  60 N  822  LEU SER LEU ASP ARG ILE TYR ASN MET LEU ARG MET PHE          
SEQRES  61 N  822  VAL VAL THR GLY PRO ALA LEU ALA GLU ILE ASP LEU GLN          
SEQRES  62 N  822  GLU LEU GLN GLY TYR LEU GLN LYS LYS VAL ARG ASP GLN          
SEQRES  63 N  822  GLN LEU VAL TYR SER ALA GLY VAL TYR ARG LEU PRO LYS          
SEQRES  64 N  822  ASN CYS SER                                                  
SEQRES   1 O  755  MET ALA SER VAL HIS GLU SER LEU TYR PHE ASN PRO MET          
SEQRES   2 O  755  MET THR ASN GLY VAL VAL HIS ALA ASN VAL PHE GLY ILE          
SEQRES   3 O  755  LYS ASP TRP VAL THR PRO TYR LYS ILE ALA VAL LEU VAL          
SEQRES   4 O  755  LEU LEU ASN GLU MET SER ARG THR GLY GLU GLY ALA VAL          
SEQRES   5 O  755  SER LEU MET GLU ARG ARG ARG LEU ASN GLN LEU LEU LEU          
SEQRES   6 O  755  PRO LEU LEU GLN GLY PRO ASP ILE THR LEU SER LYS LEU          
SEQRES   7 O  755  TYR LYS LEU ILE GLU GLU SER CYS PRO GLN LEU ALA ASN          
SEQRES   8 O  755  SER VAL GLN ILE ARG ILE LYS LEU MET ALA GLU GLY GLU          
SEQRES   9 O  755  LEU LYS ASP MET GLU GLN PHE PHE ASP ASP LEU SER ASP          
SEQRES  10 O  755  SER PHE SER GLY THR GLU PRO GLU VAL HIS LYS THR SER          
SEQRES  11 O  755  VAL VAL GLY LEU PHE LEU ARG HIS MET ILE LEU ALA TYR          
SEQRES  12 O  755  SER LYS LEU SER PHE SER GLN VAL PHE LYS LEU TYR THR          
SEQRES  13 O  755  ALA LEU GLN GLN TYR PHE GLN ASN GLY GLU LYS LYS THR          
SEQRES  14 O  755  VAL GLU ASP ALA ASP MET GLU LEU THR SER ARG ASP GLU          
SEQRES  15 O  755  GLY GLU ARG LYS MET GLU LYS GLU GLU LEU ASP VAL SER          
SEQRES  16 O  755  VAL ARG GLU GLU GLU VAL SER CYS SER GLY PRO LEU SER          
SEQRES  17 O  755  GLN LYS GLN ALA GLU PHE PHE LEU SER GLN GLN ALA SER          
SEQRES  18 O  755  LEU LEU LYS ASN ASP GLU THR LYS ALA LEU THR PRO ALA          
SEQRES  19 O  755  SER LEU GLN LYS GLU LEU ASN ASN LEU LEU LYS PHE ASN          
SEQRES  20 O  755  PRO ASP PHE ALA GLU ALA HIS TYR LEU SER TYR LEU ASN          
SEQRES  21 O  755  ASN LEU ARG VAL GLN ASP VAL PHE SER SER THR HIS SER          
SEQRES  22 O  755  LEU LEU HIS TYR PHE ASP ARG LEU ILE LEU THR GLY ALA          
SEQRES  23 O  755  GLU SER LYS SER ASN GLY GLU GLU GLY TYR GLY ARG SER          
SEQRES  24 O  755  LEU ARG TYR ALA ALA LEU ASN LEU ALA ALA LEU HIS CYS          
SEQRES  25 O  755  ARG PHE GLY HIS TYR GLN GLN ALA GLU LEU ALA LEU GLN          
SEQRES  26 O  755  GLU ALA ILE ARG ILE ALA GLN GLU SER ASN ASP HIS VAL          
SEQRES  27 O  755  CYS LEU GLN HIS CYS LEU SER TRP LEU TYR VAL LEU GLY          
SEQRES  28 O  755  GLN LYS ARG SER ASP SER TYR VAL LEU LEU GLU HIS SER          
SEQRES  29 O  755  VAL LYS LYS ALA VAL HIS PHE GLY LEU PRO TYR LEU ALA          
SEQRES  30 O  755  SER LEU GLY ILE GLN SER LEU VAL GLN GLN ARG ALA PHE          
SEQRES  31 O  755  ALA GLY LYS THR ALA ASN LYS LEU MET ASP ALA LEU LYS          
SEQRES  32 O  755  ASP SER ASP LEU LEU HIS TRP LYS HIS SER LEU SER GLU          
SEQRES  33 O  755  LEU ILE ASP ILE SER ILE ALA GLN LYS THR ALA ILE TRP          
SEQRES  34 O  755  ARG LEU TYR GLY ARG SER THR MET ALA LEU GLN GLN ALA          
SEQRES  35 O  755  GLN MET LEU LEU SER MET ASN SER LEU GLU ALA VAL ASN          
SEQRES  36 O  755  ALA GLY VAL GLN GLN ASN ASN THR GLU SER PHE ALA VAL          
SEQRES  37 O  755  ALA LEU CYS HIS LEU ALA GLU LEU HIS ALA GLU GLN GLY          
SEQRES  38 O  755  CYS PHE ALA ALA ALA SER GLU VAL LEU LYS HIS LEU LYS          
SEQRES  39 O  755  GLU ARG PHE PRO PRO ASN SER GLN HIS ALA GLN LEU TRP          
SEQRES  40 O  755  MET LEU CYS ASP GLN LYS ILE GLN PHE ASP ARG ALA MET          
SEQRES  41 O  755  ASN ASP GLY LYS TYR HIS LEU ALA ASP SER LEU VAL THR          
SEQRES  42 O  755  GLY ILE THR ALA LEU ASN SER ILE GLU GLY VAL TYR ARG          
SEQRES  43 O  755  LYS ALA VAL VAL LEU GLN ALA GLN ASN GLN MET SER GLU          
SEQRES  44 O  755  ALA HIS LYS LEU LEU GLN LYS LEU LEU VAL HIS CYS GLN          
SEQRES  45 O  755  LYS LEU LYS ASN THR GLU MET VAL ILE SER VAL LEU LEU          
SEQRES  46 O  755  SER VAL ALA GLU LEU TYR TRP ARG SER SER SER PRO THR          
SEQRES  47 O  755  ILE ALA LEU PRO MET LEU LEU GLN ALA LEU ALA LEU SER          
SEQRES  48 O  755  LYS GLU TYR ARG LEU GLN TYR LEU ALA SER GLU THR VAL          
SEQRES  49 O  755  LEU ASN LEU ALA PHE ALA GLN LEU ILE LEU GLY ILE PRO          
SEQRES  50 O  755  GLU GLN ALA LEU SER LEU LEU HIS MET ALA ILE GLU PRO          
SEQRES  51 O  755  ILE LEU ALA ASP GLY ALA ILE LEU ASP LYS GLY ARG ALA          
SEQRES  52 O  755  MET PHE LEU VAL ALA LYS CYS GLN VAL ALA SER ALA ALA          
SEQRES  53 O  755  SER TYR ASP GLN PRO LYS LYS ALA GLU ALA LEU GLU ALA          
SEQRES  54 O  755  ALA ILE GLU ASN LEU ASN GLU ALA LYS ASN TYR PHE ALA          
SEQRES  55 O  755  LYS VAL ASP CYS LYS GLU ARG ILE ARG ASP VAL VAL TYR          
SEQRES  56 O  755  PHE GLN ALA ARG LEU TYR HIS THR LEU GLY LYS THR GLN          
SEQRES  57 O  755  GLU ARG ASN ARG CYS ALA MET LEU PHE ARG GLN LEU HIS          
SEQRES  58 O  755  GLN GLU LEU PRO SER HIS GLY VAL PRO LEU ILE ASN HIS          
SEQRES  59 O  755  LEU                                                          
SEQRES   1 P  597  MET ALA ALA SER THR SER MET VAL PRO VAL ALA VAL THR          
SEQRES   2 P  597  ALA ALA VAL ALA PRO VAL LEU SER ILE ASN SER ASP PHE          
SEQRES   3 P  597  SER ASP LEU ARG GLU ILE LYS LYS GLN LEU LEU LEU ILE          
SEQRES   4 P  597  ALA GLY LEU THR ARG GLU ARG GLY LEU LEU HIS SER SER          
SEQRES   5 P  597  LYS TRP SER ALA GLU LEU ALA PHE SER LEU PRO ALA LEU          
SEQRES   6 P  597  PRO LEU ALA GLU LEU GLN PRO PRO PRO PRO ILE THR GLU          
SEQRES   7 P  597  GLU ASP ALA GLN ASP MET ASP ALA TYR THR LEU ALA LYS          
SEQRES   8 P  597  ALA TYR PHE ASP VAL LYS GLU TYR ASP ARG ALA ALA HIS          
SEQRES   9 P  597  PHE LEU HIS GLY CYS ASN SER LYS LYS ALA TYR PHE LEU          
SEQRES  10 P  597  TYR MET TYR SER ARG TYR LEU SER GLY GLU LYS LYS LYS          
SEQRES  11 P  597  ASP ASP GLU THR VAL ASP SER LEU GLY PRO LEU GLU LYS          
SEQRES  12 P  597  GLY GLN VAL LYS ASN GLU ALA LEU ARG GLU LEU ARG VAL          
SEQRES  13 P  597  GLU LEU SER LYS LYS HIS GLN ALA ARG GLU LEU ASP GLY          
SEQRES  14 P  597  PHE GLY LEU TYR LEU TYR GLY VAL VAL LEU ARG LYS LEU          
SEQRES  15 P  597  ASP LEU VAL LYS GLU ALA ILE ASP VAL PHE VAL GLU ALA          
SEQRES  16 P  597  THR HIS VAL LEU PRO LEU HIS TRP GLY ALA TRP LEU GLU          
SEQRES  17 P  597  LEU CYS ASN LEU ILE THR ASP LYS GLU MET LEU LYS PHE          
SEQRES  18 P  597  LEU SER LEU PRO ASP THR TRP MET LYS GLU PHE PHE LEU          
SEQRES  19 P  597  ALA HIS ILE TYR THR GLU LEU GLN LEU ILE GLU GLU ALA          
SEQRES  20 P  597  LEU GLN LYS TYR GLN ASN LEU ILE ASP VAL GLY PHE SER          
SEQRES  21 P  597  LYS SER SER TYR ILE VAL SER GLN ILE ALA VAL ALA TYR          
SEQRES  22 P  597  HIS ASN ILE ARG ASP ILE ASP LYS ALA LEU SER ILE PHE          
SEQRES  23 P  597  ASN GLU LEU ARG LYS GLN ASP PRO TYR ARG ILE GLU ASN          
SEQRES  24 P  597  MET ASP THR PHE SER ASN LEU LEU TYR VAL ARG SER MET          
SEQRES  25 P  597  LYS SER GLU LEU SER TYR LEU ALA HIS ASN LEU CYS GLU          
SEQRES  26 P  597  ILE ASP LYS TYR ARG VAL GLU THR CYS CYS VAL ILE GLY          
SEQRES  27 P  597  ASN TYR TYR SER LEU ARG SER GLN HIS GLU LYS ALA ALA          
SEQRES  28 P  597  LEU TYR PHE GLN ARG ALA LEU LYS LEU ASN PRO ARG TYR          
SEQRES  29 P  597  LEU GLY ALA TRP THR LEU MET GLY HIS GLU TYR MET GLU          
SEQRES  30 P  597  MET LYS ASN THR SER ALA ALA ILE GLN ALA TYR ARG HIS          
SEQRES  31 P  597  ALA ILE GLU VAL ASN LYS ARG ASP TYR ARG ALA TRP TYR          
SEQRES  32 P  597  GLY LEU GLY GLN THR TYR GLU ILE LEU LYS MET PRO PHE          
SEQRES  33 P  597  TYR CYS LEU TYR TYR TYR ARG ARG ALA HIS GLN LEU ARG          
SEQRES  34 P  597  PRO ASN ASP SER ARG MET LEU VAL ALA LEU GLY GLU CYS          
SEQRES  35 P  597  TYR GLU LYS LEU ASN GLN LEU VAL GLU ALA LYS LYS CYS          
SEQRES  36 P  597  TYR TRP ARG ALA TYR ALA VAL GLY ASP VAL GLU LYS MET          
SEQRES  37 P  597  ALA LEU VAL LYS LEU ALA LYS LEU HIS GLU GLN LEU THR          
SEQRES  38 P  597  GLU SER GLU GLN ALA ALA GLN CYS TYR ILE LYS TYR ILE          
SEQRES  39 P  597  GLN ASP ILE TYR SER CYS GLY GLU ILE VAL GLU HIS LEU          
SEQRES  40 P  597  GLU GLU SER THR ALA PHE ARG TYR LEU ALA GLN TYR TYR          
SEQRES  41 P  597  PHE LYS CYS LYS LEU TRP ASP GLU ALA SER THR CYS ALA          
SEQRES  42 P  597  GLN LYS CYS CYS ALA PHE ASN ASP THR ARG GLU GLU GLY          
SEQRES  43 P  597  LYS ALA LEU LEU ARG GLN ILE LEU GLN LEU ARG ASN GLN          
SEQRES  44 P  597  GLY GLU THR PRO THR THR GLU VAL PRO ALA PRO PHE PHE          
SEQRES  45 P  597  LEU PRO ALA SER LEU SER ALA ASN ASN THR PRO THR ARG          
SEQRES  46 P  597  ARG VAL SER PRO LEU ASN LEU SER SER VAL THR PRO              
SEQRES   1 Q  374  GLU GLU ALA LYS ILE LEU ARG LEU SER GLY LYS PRO GLN          
SEQRES   2 Q  374  ASN ALA PRO GLU GLY TYR GLN ASN ARG LEU LYS VAL LEU          
SEQRES   3 Q  374  TYR SER GLN LYS ALA THR PRO GLY SER SER ARG LYS THR          
SEQRES   4 Q  374  CYS ARG TYR ILE PRO SER LEU PRO ASP ARG ILE LEU ASP          
SEQRES   5 Q  374  ALA PRO GLU ILE ARG ASN ASP TYR TYR LEU ASN LEU VAL          
SEQRES   6 Q  374  ASP TRP SER SER GLY ASN VAL LEU ALA VAL ALA LEU ASP          
SEQRES   7 Q  374  ASN SER VAL TYR LEU TRP SER ALA SER SER GLY ASP ILE          
SEQRES   8 Q  374  LEU GLN LEU LEU GLN MET GLU GLN PRO GLY GLU TYR ILE          
SEQRES   9 Q  374  SER SER VAL ALA TRP ILE LYS GLU GLY ASN TYR LEU ALA          
SEQRES  10 Q  374  VAL GLY THR SER SER ALA GLU VAL GLN LEU TRP ASP VAL          
SEQRES  11 Q  374  GLN GLN GLN LYS ARG LEU ARG ASN MET THR SER HIS SER          
SEQRES  12 Q  374  ALA ARG VAL GLY SER LEU SER TRP ASN SER TYR ILE LEU          
SEQRES  13 Q  374  SER SER GLY SER ARG SER GLY HIS ILE HIS HIS HIS ASP          
SEQRES  14 Q  374  VAL ARG VAL ALA GLU HIS HIS VAL ALA THR LEU SER GLY          
SEQRES  15 Q  374  HIS SER GLN GLU VAL CYS GLY LEU ARG TRP ALA PRO ASP          
SEQRES  16 Q  374  GLY ARG HIS LEU ALA SER GLY GLY ASN ASP ASN LEU VAL          
SEQRES  17 Q  374  ASN VAL TRP PRO SER ALA PRO GLY GLU GLY GLY TRP VAL          
SEQRES  18 Q  374  PRO LEU GLN THR PHE THR GLN HIS GLN GLY ALA VAL LYS          
SEQRES  19 Q  374  ALA VAL ALA TRP CYS PRO TRP GLN SER ASN VAL LEU ALA          
SEQRES  20 Q  374  THR GLY GLY GLY THR SER ASP ARG HIS ILE ARG ILE TRP          
SEQRES  21 Q  374  ASN VAL CYS SER GLY ALA CYS LEU SER ALA VAL ASP ALA          
SEQRES  22 Q  374  HIS SER GLN VAL CYS SER ILE LEU TRP SER PRO HIS TYR          
SEQRES  23 Q  374  LYS GLU LEU ILE SER GLY HIS GLY PHE ALA GLN ASN GLN          
SEQRES  24 Q  374  LEU VAL ILE TRP LYS TYR PRO THR MET ALA LYS VAL ALA          
SEQRES  25 Q  374  GLU LEU LYS GLY HIS THR SER ARG VAL LEU SER LEU THR          
SEQRES  26 Q  374  MET SER PRO ASP GLY ALA THR VAL ALA SER ALA ALA ALA          
SEQRES  27 Q  374  ASP GLU THR LEU ARG LEU TRP ARG CYS PHE GLU LEU ASP          
SEQRES  28 Q  374  PRO ALA ARG ARG ARG GLU ARG GLU LYS ALA SER ALA ALA          
SEQRES  29 Q  374  LYS SER SER LEU ILE HIS GLN GLY ILE ARG                      
SEQRES   1 R  499  MET ALA GLN PHE ALA PHE GLU SER ASP LEU HIS SER LEU          
SEQRES   2 R  499  LEU GLN LEU ASP ALA PRO ILE PRO ASN ALA PRO PRO ALA          
SEQRES   3 R  499  ARG TRP GLN ARG LYS ALA LYS GLU ALA ALA GLY PRO ALA          
SEQRES   4 R  499  PRO SER PRO MET ARG ALA ALA ASN ARG SER HIS SER ALA          
SEQRES   5 R  499  GLY ARG THR PRO GLY ARG THR PRO GLY LYS SER SER SER          
SEQRES   6 R  499  LYS VAL GLN THR THR PRO SER LYS PRO GLY GLY ASP ARG          
SEQRES   7 R  499  TYR ILE PRO HIS ARG SER ALA ALA GLN MET GLU VAL ALA          
SEQRES   8 R  499  SER PHE LEU LEU SER LYS GLU ASN GLN PRO GLU ASN SER          
SEQRES   9 R  499  GLN THR PRO THR LYS LYS GLU HIS GLN LYS ALA TRP ALA          
SEQRES  10 R  499  LEU ASN LEU ASN GLY PHE ASP VAL GLU GLU ALA LYS ILE          
SEQRES  11 R  499  LEU ARG LEU SER GLY LYS PRO GLN ASN ALA PRO GLU GLY          
SEQRES  12 R  499  TYR GLN ASN ARG LEU LYS VAL LEU TYR SER GLN LYS ALA          
SEQRES  13 R  499  THR PRO GLY SER SER ARG LYS THR CYS ARG TYR ILE PRO          
SEQRES  14 R  499  SER LEU PRO ASP ARG ILE LEU ASP ALA PRO GLU ILE ARG          
SEQRES  15 R  499  ASN ASP TYR TYR LEU ASN LEU VAL ASP TRP SER SER GLY          
SEQRES  16 R  499  ASN VAL LEU ALA VAL ALA LEU ASP ASN SER VAL TYR LEU          
SEQRES  17 R  499  TRP SER ALA SER SER GLY ASP ILE LEU GLN LEU LEU GLN          
SEQRES  18 R  499  MET GLU GLN PRO GLY GLU TYR ILE SER SER VAL ALA TRP          
SEQRES  19 R  499  ILE LYS GLU GLY ASN TYR LEU ALA VAL GLY THR SER SER          
SEQRES  20 R  499  ALA GLU VAL GLN LEU TRP ASP VAL GLN GLN GLN LYS ARG          
SEQRES  21 R  499  LEU ARG ASN MET THR SER HIS SER ALA ARG VAL GLY SER          
SEQRES  22 R  499  LEU SER TRP ASN SER TYR ILE LEU SER SER GLY SER ARG          
SEQRES  23 R  499  SER GLY HIS ILE HIS HIS HIS ASP VAL ARG VAL ALA GLU          
SEQRES  24 R  499  HIS HIS VAL ALA THR LEU SER GLY HIS SER GLN GLU VAL          
SEQRES  25 R  499  CYS GLY LEU ARG TRP ALA PRO ASP GLY ARG HIS LEU ALA          
SEQRES  26 R  499  SER GLY GLY ASN ASP ASN LEU VAL ASN VAL TRP PRO SER          
SEQRES  27 R  499  ALA PRO GLY GLU GLY GLY TRP VAL PRO LEU GLN THR PHE          
SEQRES  28 R  499  THR GLN HIS GLN GLY ALA VAL LYS ALA VAL ALA TRP CYS          
SEQRES  29 R  499  PRO TRP GLN SER ASN VAL LEU ALA THR GLY GLY GLY THR          
SEQRES  30 R  499  SER ASP ARG HIS ILE ARG ILE TRP ASN VAL CYS SER GLY          
SEQRES  31 R  499  ALA CYS LEU SER ALA VAL ASP ALA HIS SER GLN VAL CYS          
SEQRES  32 R  499  SER ILE LEU TRP SER PRO HIS TYR LYS GLU LEU ILE SER          
SEQRES  33 R  499  GLY HIS GLY PHE ALA GLN ASN GLN LEU VAL ILE TRP LYS          
SEQRES  34 R  499  TYR PRO THR MET ALA LYS VAL ALA GLU LEU LYS GLY HIS          
SEQRES  35 R  499  THR SER ARG VAL LEU SER LEU THR MET SER PRO ASP GLY          
SEQRES  36 R  499  ALA THR VAL ALA SER ALA ALA ALA ASP GLU THR LEU ARG          
SEQRES  37 R  499  LEU TRP ARG CYS PHE GLU LEU ASP PRO ALA ARG ARG ARG          
SEQRES  38 R  499  GLU ARG GLU LYS ALA SER ALA ALA LYS SER SER LEU ILE          
SEQRES  39 R  499  HIS GLN GLY ILE ARG                                          
SEQRES   1 S  342  MET ALA ALA VAL LYS LYS GLU GLY GLY ALA LEU SER GLU          
SEQRES   2 S  342  ALA MET SER LEU GLU GLY ASP GLU TRP GLU LEU SER LYS          
SEQRES   3 S  342  GLU ASN VAL GLN PRO LEU ARG GLN GLY ARG ILE MET SER          
SEQRES   4 S  342  THR LEU GLN GLY ALA LEU ALA GLN GLU SER ALA CYS ASN          
SEQRES   5 S  342  ASN THR LEU GLN GLN GLN LYS ARG ALA PHE GLU TYR GLU          
SEQRES   6 S  342  ILE ARG PHE TYR THR GLY ASN ASP PRO LEU ASP VAL TRP          
SEQRES   7 S  342  ASP ARG TYR ILE SER TRP THR GLU GLN ASN TYR PRO GLN          
SEQRES   8 S  342  GLY GLY LYS GLU SER ASN MET SER THR LEU LEU GLU ARG          
SEQRES   9 S  342  ALA VAL GLU ALA LEU GLN GLY GLU LYS ARG TYR TYR SER          
SEQRES  10 S  342  ASP PRO ARG PHE LEU ASN LEU TRP LEU LYS LEU GLY ARG          
SEQRES  11 S  342  LEU CYS ASN GLU PRO LEU ASP MET TYR SER TYR LEU HIS          
SEQRES  12 S  342  ASN GLN GLY ILE GLY VAL SER LEU ALA GLN PHE TYR ILE          
SEQRES  13 S  342  SER TRP ALA GLU GLU TYR GLU ALA ARG GLU ASN PHE ARG          
SEQRES  14 S  342  LYS ALA ASP ALA ILE PHE GLN GLU GLY ILE GLN GLN LYS          
SEQRES  15 S  342  ALA GLU PRO LEU GLU ARG LEU GLN SER GLN HIS ARG GLN          
SEQRES  16 S  342  PHE GLN ALA ARG VAL SER ARG GLN THR LEU LEU ALA LEU          
SEQRES  17 S  342  GLU LYS GLU GLU GLU GLU GLU VAL PHE GLU SER SER VAL          
SEQRES  18 S  342  PRO GLN ARG SER THR LEU ALA GLU LEU LYS SER LYS GLY          
SEQRES  19 S  342  LYS LYS THR ALA ARG ALA PRO ILE ILE ARG VAL GLY GLY          
SEQRES  20 S  342  ALA LEU LYS ALA PRO SER GLN ASN ARG GLY LEU GLN ASN          
SEQRES  21 S  342  PRO PHE PRO GLN GLN MET GLN ASN ASN SER ARG ILE THR          
SEQRES  22 S  342  VAL PHE ASP GLU ASN ALA ASP GLU ALA SER THR ALA GLU          
SEQRES  23 S  342  LEU SER LYS PRO THR VAL GLN PRO TRP ILE ALA PRO PRO          
SEQRES  24 S  342  MET PRO ARG ALA LYS GLU ASN GLU LEU GLN ALA SER ILE          
SEQRES  25 S  342  PHE ASP GLU PHE LEU LEU SER GLU LYS LYS ASN LYS SER          
SEQRES  26 S  342  PRO PRO ALA ASP PRO PRO ARG VAL LEU ALA GLN ARG ARG          
SEQRES  27 S  342  PRO LEU ALA VAL                                              
SEQRES   1 W   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 W   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 W   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 W   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 W   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 W   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 W   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 X  599  MET ASP PRO GLY ASP ALA ALA ILE LEU GLU SER SER LEU          
SEQRES   2 X  599  ARG ILE LEU TYR ARG LEU PHE GLU SER VAL LEU PRO PRO          
SEQRES   3 X  599  LEU PRO ALA ALA LEU GLN SER ARG MET ASN VAL ILE ASP          
SEQRES   4 X  599  HIS VAL ARG ASP MET ALA ALA ALA GLY LEU HIS SER ASN          
SEQRES   5 X  599  VAL ARG LEU LEU SER SER LEU LEU LEU THR MET SER ASN          
SEQRES   6 X  599  ASN ASN PRO GLU LEU PHE SER PRO PRO GLN LYS TYR GLN          
SEQRES   7 X  599  LEU LEU VAL TYR HIS ALA ASP SER LEU PHE HIS ASP LYS          
SEQRES   8 X  599  GLU TYR ARG ASN ALA VAL SER LYS TYR THR MET ALA LEU          
SEQRES   9 X  599  GLN GLN LYS LYS ALA LEU SER LYS THR SER LYS VAL ARG          
SEQRES  10 X  599  PRO SER THR GLY ASN SER ALA SER THR PRO GLN SER GLN          
SEQRES  11 X  599  CYS LEU PRO SER GLU ILE GLU VAL LYS TYR LYS MET ALA          
SEQRES  12 X  599  GLU CYS TYR THR MET LEU LYS GLN ASP LYS ASP ALA ILE          
SEQRES  13 X  599  ALA ILE LEU ASP GLY ILE PRO SER ARG GLN ARG THR PRO          
SEQRES  14 X  599  LYS ILE ASN MET MET LEU ALA ASN LEU TYR LYS LYS ALA          
SEQRES  15 X  599  GLY GLN GLU ARG PRO SER VAL THR SER TYR LYS GLU VAL          
SEQRES  16 X  599  LEU ARG GLN CYS PRO LEU ALA LEU ASP ALA ILE LEU GLY          
SEQRES  17 X  599  LEU LEU SER LEU SER VAL LYS GLY ALA GLU VAL ALA SER          
SEQRES  18 X  599  MET THR MET ASN VAL ILE GLN THR VAL PRO ASN LEU ASP          
SEQRES  19 X  599  TRP LEU SER VAL TRP ILE LYS ALA TYR ALA PHE VAL HIS          
SEQRES  20 X  599  THR GLY ASP ASN SER ARG ALA ILE SER THR ILE CYS SER          
SEQRES  21 X  599  LEU GLU LYS LYS SER LEU LEU ARG ASP ASN VAL ASP LEU          
SEQRES  22 X  599  LEU GLY SER LEU ALA ASP LEU TYR PHE ARG ALA GLY ASP          
SEQRES  23 X  599  ASN LYS ASN SER VAL LEU LYS PHE GLU GLN ALA GLN MET          
SEQRES  24 X  599  LEU ASP PRO TYR LEU ILE LYS GLY MET ASP VAL TYR GLY          
SEQRES  25 X  599  TYR LEU LEU ALA ARG GLU GLY ARG LEU GLU ASP VAL GLU          
SEQRES  26 X  599  ASN LEU GLY CYS ARG LEU PHE ASN ILE SER ASP GLN HIS          
SEQRES  27 X  599  ALA GLU PRO TRP VAL VAL SER GLY CYS HIS SER PHE TYR          
SEQRES  28 X  599  SER LYS ARG TYR SER ARG ALA LEU TYR LEU GLY ALA LYS          
SEQRES  29 X  599  ALA ILE GLN LEU ASN SER ASN SER VAL GLN ALA LEU LEU          
SEQRES  30 X  599  LEU LYS GLY ALA ALA LEU ARG ASN MET GLY ARG VAL GLN          
SEQRES  31 X  599  GLU ALA ILE ILE HIS PHE ARG GLU ALA ILE ARG LEU ALA          
SEQRES  32 X  599  PRO CYS ARG LEU ASP CYS TYR GLU GLY LEU ILE GLU CYS          
SEQRES  33 X  599  TYR LEU ALA SER ASN SER ILE ARG GLU ALA MET VAL MET          
SEQRES  34 X  599  ALA ASN ASN VAL TYR LYS THR LEU GLY ALA ASN ALA GLN          
SEQRES  35 X  599  THR LEU THR LEU LEU ALA THR VAL CYS LEU GLU ASP PRO          
SEQRES  36 X  599  VAL THR GLN GLU LYS ALA LYS THR LEU LEU ASP LYS ALA          
SEQRES  37 X  599  LEU THR GLN ARG PRO ASP TYR ILE LYS ALA VAL VAL LYS          
SEQRES  38 X  599  LYS ALA GLU LEU LEU SER ARG GLU GLN LYS TYR GLU ASP          
SEQRES  39 X  599  GLY ILE ALA LEU LEU ARG ASN ALA LEU ALA ASN GLN SER          
SEQRES  40 X  599  ASP CYS VAL LEU HIS ARG ILE LEU GLY ASP PHE LEU VAL          
SEQRES  41 X  599  ALA VAL ASN GLU TYR GLN GLU ALA MET ASP GLN TYR SER          
SEQRES  42 X  599  ILE ALA LEU SER LEU ASP PRO ASN ASP GLN LYS SER LEU          
SEQRES  43 X  599  GLU GLY MET GLN LYS MET GLU LYS GLU GLU SER PRO THR          
SEQRES  44 X  599  ASP ALA THR GLN GLU GLU ASP VAL ASP ASP MET GLU GLY          
SEQRES  45 X  599  SER GLY GLU GLU GLY ASP LEU GLU GLY SER ASP SER GLU          
SEQRES  46 X  599  ALA ALA GLN TRP ALA ASP GLN GLU GLN TRP PHE GLY MET          
SEQRES  47 X  599  GLN                                                          
SEQRES   1 Y  599  MET ASP PRO GLY ASP ALA ALA ILE LEU GLU SER SER LEU          
SEQRES   2 Y  599  ARG ILE LEU TYR ARG LEU PHE GLU SER VAL LEU PRO PRO          
SEQRES   3 Y  599  LEU PRO ALA ALA LEU GLN SER ARG MET ASN VAL ILE ASP          
SEQRES   4 Y  599  HIS VAL ARG ASP MET ALA ALA ALA GLY LEU HIS SER ASN          
SEQRES   5 Y  599  VAL ARG LEU LEU SER SER LEU LEU LEU THR MET SER ASN          
SEQRES   6 Y  599  ASN ASN PRO GLU LEU PHE SER PRO PRO GLN LYS TYR GLN          
SEQRES   7 Y  599  LEU LEU VAL TYR HIS ALA ASP SER LEU PHE HIS ASP LYS          
SEQRES   8 Y  599  GLU TYR ARG ASN ALA VAL SER LYS TYR THR MET ALA LEU          
SEQRES   9 Y  599  GLN GLN LYS LYS ALA LEU SER LYS THR SER LYS VAL ARG          
SEQRES  10 Y  599  PRO SER THR GLY ASN SER ALA SER THR PRO GLN SER GLN          
SEQRES  11 Y  599  CYS LEU PRO SER GLU ILE GLU VAL LYS TYR LYS MET ALA          
SEQRES  12 Y  599  GLU CYS TYR THR MET LEU LYS GLN ASP LYS ASP ALA ILE          
SEQRES  13 Y  599  ALA ILE LEU ASP GLY ILE PRO SER ARG GLN ARG THR PRO          
SEQRES  14 Y  599  LYS ILE ASN MET MET LEU ALA ASN LEU TYR LYS LYS ALA          
SEQRES  15 Y  599  GLY GLN GLU ARG PRO SER VAL THR SER TYR LYS GLU VAL          
SEQRES  16 Y  599  LEU ARG GLN CYS PRO LEU ALA LEU ASP ALA ILE LEU GLY          
SEQRES  17 Y  599  LEU LEU SER LEU SER VAL LYS GLY ALA GLU VAL ALA SER          
SEQRES  18 Y  599  MET THR MET ASN VAL ILE GLN THR VAL PRO ASN LEU ASP          
SEQRES  19 Y  599  TRP LEU SER VAL TRP ILE LYS ALA TYR ALA PHE VAL HIS          
SEQRES  20 Y  599  THR GLY ASP ASN SER ARG ALA ILE SER THR ILE CYS SER          
SEQRES  21 Y  599  LEU GLU LYS LYS SER LEU LEU ARG ASP ASN VAL ASP LEU          
SEQRES  22 Y  599  LEU GLY SER LEU ALA ASP LEU TYR PHE ARG ALA GLY ASP          
SEQRES  23 Y  599  ASN LYS ASN SER VAL LEU LYS PHE GLU GLN ALA GLN MET          
SEQRES  24 Y  599  LEU ASP PRO TYR LEU ILE LYS GLY MET ASP VAL TYR GLY          
SEQRES  25 Y  599  TYR LEU LEU ALA ARG GLU GLY ARG LEU GLU ASP VAL GLU          
SEQRES  26 Y  599  ASN LEU GLY CYS ARG LEU PHE ASN ILE SER ASP GLN HIS          
SEQRES  27 Y  599  ALA GLU PRO TRP VAL VAL SER GLY CYS HIS SER PHE TYR          
SEQRES  28 Y  599  SER LYS ARG TYR SER ARG ALA LEU TYR LEU GLY ALA LYS          
SEQRES  29 Y  599  ALA ILE GLN LEU ASN SER ASN SER VAL GLN ALA LEU LEU          
SEQRES  30 Y  599  LEU LYS GLY ALA ALA LEU ARG ASN MET GLY ARG VAL GLN          
SEQRES  31 Y  599  GLU ALA ILE ILE HIS PHE ARG GLU ALA ILE ARG LEU ALA          
SEQRES  32 Y  599  PRO CYS ARG LEU ASP CYS TYR GLU GLY LEU ILE GLU CYS          
SEQRES  33 Y  599  TYR LEU ALA SER ASN SER ILE ARG GLU ALA MET VAL MET          
SEQRES  34 Y  599  ALA ASN ASN VAL TYR LYS THR LEU GLY ALA ASN ALA GLN          
SEQRES  35 Y  599  THR LEU THR LEU LEU ALA THR VAL CYS LEU GLU ASP PRO          
SEQRES  36 Y  599  VAL THR GLN GLU LYS ALA LYS THR LEU LEU ASP LYS ALA          
SEQRES  37 Y  599  LEU THR GLN ARG PRO ASP TYR ILE LYS ALA VAL VAL LYS          
SEQRES  38 Y  599  LYS ALA GLU LEU LEU SER ARG GLU GLN LYS TYR GLU ASP          
SEQRES  39 Y  599  GLY ILE ALA LEU LEU ARG ASN ALA LEU ALA ASN GLN SER          
SEQRES  40 Y  599  ASP CYS VAL LEU HIS ARG ILE LEU GLY ASP PHE LEU VAL          
SEQRES  41 Y  599  ALA VAL ASN GLU TYR GLN GLU ALA MET ASP GLN TYR SER          
SEQRES  42 Y  599  ILE ALA LEU SER LEU ASP PRO ASN ASP GLN LYS SER LEU          
SEQRES  43 Y  599  GLU GLY MET GLN LYS MET GLU LYS GLU GLU SER PRO THR          
SEQRES  44 Y  599  ASP ALA THR GLN GLU GLU ASP VAL ASP ASP MET GLU GLY          
SEQRES  45 Y  599  SER GLY GLU GLU GLY ASP LEU GLU GLY SER ASP SER GLU          
SEQRES  46 Y  599  ALA ALA GLN TRP ALA ASP GLN GLU GLN TRP PHE GLY MET          
SEQRES  47 Y  599  GLN                                                          
SEQRES   1 Z  205  MET ALA LEU GLN LEU SER ARG GLU GLN GLY ILE THR LEU          
SEQRES   2 Z  205  ARG GLY SER ALA GLU ILE VAL ALA GLU PHE PHE SER PHE          
SEQRES   3 Z  205  GLY ILE ASN SER ILE LEU TYR GLN ARG GLY ILE TYR PRO          
SEQRES   4 Z  205  SER GLU THR PHE THR ARG VAL GLN LYS TYR GLY LEU THR          
SEQRES   5 Z  205  LEU LEU VAL THR THR ASP LEU GLU LEU ILE LYS TYR LEU          
SEQRES   6 Z  205  ASN ASN VAL VAL GLU GLN LEU LYS ASP TRP LEU TYR LYS          
SEQRES   7 Z  205  CYS SER VAL GLN LYS LEU VAL VAL VAL ILE SER ASN ILE          
SEQRES   8 Z  205  GLU SER GLY GLU VAL LEU GLU ARG TRP GLN PHE ASP ILE          
SEQRES   9 Z  205  GLU CYS ASP LYS THR ALA LYS ASP ASP SER ALA PRO ARG          
SEQRES  10 Z  205  GLU LYS SER GLN LYS ALA ILE GLN ASP GLU ILE ARG SER          
SEQRES  11 Z  205  VAL ILE ARG GLN ILE THR ALA THR VAL THR PHE LEU PRO          
SEQRES  12 Z  205  LEU LEU GLU VAL SER CYS SER PHE ASP LEU LEU ILE TYR          
SEQRES  13 Z  205  THR ASP LYS ASP LEU VAL VAL PRO GLU LYS TRP GLU GLU          
SEQRES  14 Z  205  SER GLY PRO GLN PHE ILE THR ASN SER GLU GLU VAL ARG          
SEQRES  15 Z  205  LEU ARG SER PHE THR THR THR ILE HIS LYS VAL ASN SER          
SEQRES  16 Z  205  MET VAL ALA TYR LYS ILE PRO VAL ASN ASP                      
HELIX    1 AA1 PRO A   22  HIS A   30  1                                   9    
HELIX    2 AA2 LEU A  350  VAL A  360  1                                  11    
HELIX    3 AA3 SER A  615  LEU A  629  1                                  15    
HELIX    4 AA4 LYS A  631  SER A  646  1                                  16    
HELIX    5 AA5 SER A  655  MET A  667  1                                  13    
HELIX    6 AA6 HIS A  758  THR A  777  1                                  20    
HELIX    7 AA7 GLU A  781  LYS A  798  1                                  18    
HELIX    8 AA8 GLY A  800  TYR A  810  1                                  11    
HELIX    9 AA9 SER A  843  GLY A  854  1                                  12    
HELIX   10 AB1 CYS A  867  LEU A  882  1                                  16    
HELIX   11 AB2 SER A  925  VAL A  937  1                                  13    
HELIX   12 AB3 THR A  940  GLU A  945  1                                   6    
HELIX   13 AB4 PRO A  948  GLN A  965  1                                  18    
HELIX   14 AB5 PRO A  971  ILE A  978  1                                   8    
HELIX   15 AB6 ARG A  980  SER A  984  5                                   5    
HELIX   16 AB7 ASN A 1020  TRP A 1028  1                                   9    
HELIX   17 AB8 LEU A 1032  GLN A 1042  1                                  11    
HELIX   18 AB9 SER A 1058  THR A 1088  1                                  31    
HELIX   19 AC1 THR A 1132  LEU A 1145  1                                  14    
HELIX   20 AC2 ASP A 1154  ASN A 1161  1                                   8    
HELIX   21 AC3 LEU A 1168  GLY A 1183  1                                  16    
HELIX   22 AC4 HIS A 1184  LEU A 1188  5                                   5    
HELIX   23 AC5 ALA A 1189  LYS A 1199  1                                  11    
HELIX   24 AC6 HIS A 1201  LEU A 1217  1                                  17    
HELIX   25 AC7 ASP A 1221  ILE A 1232  1                                  12    
HELIX   26 AC8 PRO A 1246  TYR A 1261  1                                  16    
HELIX   27 AC9 HIS A 1266  GLY A 1278  1                                  13    
HELIX   28 AD1 ASP A 1290  LEU A 1307  1                                  18    
HELIX   29 AD2 ASN A 1320  GLY A 1331  1                                  12    
HELIX   30 AD3 ASN A 1359  TYR A 1375  1                                  17    
HELIX   31 AD4 ASN A 1380  LEU A 1387  1                                   8    
HELIX   32 AD5 THR A 1392  VAL A 1399  1                                   8    
HELIX   33 AD6 LYS A 1400  LEU A 1415  1                                  16    
HELIX   34 AD7 ASN A 1422  ASN A 1429  1                                   8    
HELIX   35 AD8 PRO A 1431  ASN A 1437  1                                   7    
HELIX   36 AD9 ASN A 1453  ALA A 1477  1                                  25    
HELIX   37 AE1 ASN A 1481  SER A 1500  1                                  20    
HELIX   38 AE2 ASN A 1503  GLY A 1508  1                                   6    
HELIX   39 AE3 GLY A 1508  MET A 1527  1                                  20    
HELIX   40 AE4 ASN A 1532  THR A 1546  1                                  15    
HELIX   41 AE5 ASN A 1551  PHE A 1566  1                                  16    
HELIX   42 AE6 LEU A 1567  GLY A 1570  5                                   4    
HELIX   43 AE7 ASN A 1578  TYR A 1589  1                                  12    
HELIX   44 AE8 GLN A 1604  HIS A 1608  5                                   5    
HELIX   45 AE9 LEU A 1609  ALA A 1613  1                                   5    
HELIX   46 AF1 GLN A 1685  LYS A 1693  1                                   9    
HELIX   47 AF2 ASP A 1744  CYS A 1755  1                                  12    
HELIX   48 AF3 LYS A 1764  GLN A 1781  1                                  18    
HELIX   49 AF4 GLU A 1785  ARG A 1803  1                                  19    
HELIX   50 AF5 THR A 1808  SER A 1822  1                                  15    
HELIX   51 AF6 PHE A 1844  GLY A 1863  1                                  20    
HELIX   52 AF7 GLY A 1864  SER A 1873  1                                  10    
HELIX   53 AF8 GLU A 1878  SER A 1893  1                                  16    
HELIX   54 AF9 GLU A 1913  LYS A 1922  1                                  10    
HELIX   55 AG1 ARG A 1926  LEU A 1936  1                                  11    
HELIX   56 AG2 MET B   57  HIS B   65  1                                   9    
HELIX   57 AG3 ASP C   28  GLY C   47  1                                  20    
HELIX   58 AG4 LEU C   48  LEU C   62  1                                  15    
HELIX   59 AG5 THR C   77  LYS C   97  1                                  21    
HELIX   60 AG6 GLU C   98  LEU C  106  1                                   9    
HELIX   61 AG7 HIS C  107  CYS C  109  5                                   3    
HELIX   62 AG8 SER C  111  SER C  137  1                                  27    
HELIX   63 AG9 GLU C  149  ARG C  165  1                                  17    
HELIX   64 AH1 GLY C  169  LEU C  182  1                                  14    
HELIX   65 AH2 LEU C  184  LEU C  199  1                                  16    
HELIX   66 AH3 HIS C  202  ILE C  213  1                                  12    
HELIX   67 AH4 ASP C  215  LEU C  222  1                                   8    
HELIX   68 AH5 TRP C  228  GLN C  242  1                                  15    
HELIX   69 AH6 LEU C  243  VAL C  257  1                                  15    
HELIX   70 AH7 SER C  262  ARG C  277  1                                  16    
HELIX   71 AH8 ASP C  278  ASP C  293  1                                  16    
HELIX   72 AH9 ASN C  299  ARG C  310  1                                  12    
HELIX   73 AI1 MET C  312  ASP C  327  1                                  16    
HELIX   74 AI2 ARG C  330  ARG C  344  1                                  15    
HELIX   75 AI3 GLN C  346  ASN C  361  1                                  16    
HELIX   76 AI4 TYR C  364  MET C  378  1                                  15    
HELIX   77 AI5 ASN C  380  ASN C  395  1                                  16    
HELIX   78 AI6 ASP C  398  LEU C  412  1                                  15    
HELIX   79 AI7 MET C  414  ARG C  429  1                                  16    
HELIX   80 AI8 ASP C  432  ASN C  447  1                                  16    
HELIX   81 AI9 GLN C  448  GLY C  463  1                                  16    
HELIX   82 AJ1 MET C  468  LEU C  480  1                                  13    
HELIX   83 AJ2 SER C  483  CYS C  500  1                                  18    
HELIX   84 AJ3 SER C  510  CYS C  523  1                                  14    
HELIX   85 AJ4 LEU C  525  ASN C  540  1                                  16    
HELIX   86 AJ5 ARG C  543  ARG C  557  1                                  15    
HELIX   87 AJ6 PHE E   53  ASP E   92  1                                  40    
HELIX   88 AJ7 GLU E   93  PHE E   96  5                                   4    
HELIX   89 AJ8 PRO E   98  LEU E  103  1                                   6    
HELIX   90 AJ9 GLU F    6  HIS F   18  1                                  13    
HELIX   91 AK1 ALA F   20  HIS F   36  1                                  17    
HELIX   92 AK2 SER F   37  SER F   51  1                                  15    
HELIX   93 AK3 LYS F   53  HIS F   64  1                                  12    
HELIX   94 AK4 THR F   68  LEU F   82  1                                  15    
HELIX   95 AK5 LYS F   84  GLY F   94  1                                  11    
HELIX   96 AK6 HIS F  103  GLY F  111  1                                   9    
HELIX   97 AK7 SER F  113  ASP F  129  1                                  17    
HELIX   98 AK8 ARG F  130  ASN F  145  1                                  16    
HELIX   99 AK9 LEU F  148  ILE F  158  1                                  11    
HELIX  100 AL1 PHE F  452  TYR F  479  1                                  28    
HELIX  101 AL2 ASN F  480  HIS F  490  1                                  11    
HELIX  102 AL3 THR F  498  SER F  513  1                                  16    
HELIX  103 AL4 GLU F  514  GLU F  529  1                                  16    
HELIX  104 AL5 GLY F  535  GLN F  547  1                                  13    
HELIX  105 AL6 LYS F  548  ASP F  563  1                                  16    
HELIX  106 AL7 SER F  566  GLN F  580  1                                  15    
HELIX  107 AL8 GLU F  582  ASP F  597  1                                  16    
HELIX  108 AL9 TYR F  600  GLU F  615  1                                  16    
HELIX  109 AM1 GLU F  616  ASN F  631  1                                  16    
HELIX  110 AM2 HIS F  634  GLN F  648  1                                  15    
HELIX  111 AM3 LYS F  650  ASN F  665  1                                  16    
HELIX  112 AM4 SER F  668  LEU F  682  1                                  15    
HELIX  113 AM5 LYS F  684  ASP F  699  1                                  16    
HELIX  114 AM6 ASN F  702  ASN F  716  1                                  15    
HELIX  115 AM7 LYS F  718  VAL F  733  1                                  16    
HELIX  116 AM8 GLU F  736  GLY F  751  1                                  16    
HELIX  117 AM9 GLN F  752  ASP F  767  1                                  16    
HELIX  118 AN1 LYS G   12  ASP G   25  1                                  14    
HELIX  119 AN2 GLU H    6  HIS H   18  1                                  13    
HELIX  120 AN3 ALA H   20  HIS H   36  1                                  17    
HELIX  121 AN4 SER H   37  SER H   51  1                                  15    
HELIX  122 AN5 LYS H   53  HIS H   64  1                                  12    
HELIX  123 AN6 THR H   68  LEU H   82  1                                  15    
HELIX  124 AN7 LYS H   84  GLY H   94  1                                  11    
HELIX  125 AN8 HIS H  103  GLY H  111  1                                   9    
HELIX  126 AN9 SER H  113  ASP H  129  1                                  17    
HELIX  127 AO1 ARG H  130  ASN H  145  1                                  16    
HELIX  128 AO2 LEU H  148  ILE H  158  1                                  11    
HELIX  129 AO3 ASP H  163  LYS H  169  1                                   7    
HELIX  130 AO4 PHE H  452  TYR H  479  1                                  28    
HELIX  131 AO5 ASN H  480  HIS H  490  1                                  11    
HELIX  132 AO6 THR H  498  SER H  513  1                                  16    
HELIX  133 AO7 GLU H  514  GLU H  529  1                                  16    
HELIX  134 AO8 GLY H  535  GLN H  547  1                                  13    
HELIX  135 AO9 LYS H  548  ASP H  563  1                                  16    
HELIX  136 AP1 SER H  566  GLN H  580  1                                  15    
HELIX  137 AP2 GLU H  582  ASP H  597  1                                  16    
HELIX  138 AP3 TYR H  600  GLU H  615  1                                  16    
HELIX  139 AP4 GLU H  616  ASN H  631  1                                  16    
HELIX  140 AP5 HIS H  634  GLN H  648  1                                  15    
HELIX  141 AP6 LYS H  650  ASN H  665  1                                  16    
HELIX  142 AP7 SER H  668  LEU H  682  1                                  15    
HELIX  143 AP8 LYS H  684  ASP H  699  1                                  16    
HELIX  144 AP9 ASN H  702  ASN H  716  1                                  15    
HELIX  145 AQ1 LYS H  718  VAL H  733  1                                  16    
HELIX  146 AQ2 GLU H  736  GLY H  751  1                                  16    
HELIX  147 AQ3 GLN H  752  ASP H  767  1                                  16    
HELIX  148 AQ4 LEU I   49  PHE I   52  5                                   4    
HELIX  149 AQ5 ASP I  133  LEU I  137  1                                   5    
HELIX  150 AQ6 GLU I  163  ASP I  170  1                                   8    
HELIX  151 AQ7 THR I  238  PHE I  244  1                                   7    
HELIX  152 AQ8 PHE I  244  LYS I  294  1                                  51    
HELIX  153 AQ9 GLN I  301  TRP I  310  1                                  10    
HELIX  154 AR1 ALA I  315  LEU I  325  1                                  11    
HELIX  155 AR2 THR I  326  HIS I  351  1                                  26    
HELIX  156 AR3 HIS I  351  TRP I  372  1                                  22    
HELIX  157 AR4 TRP I  372  GLU I  377  1                                   6    
HELIX  158 AR5 ASP I  382  THR I  429  1                                  48    
HELIX  159 AR6 THR I  441  PHE I  456  1                                  16    
HELIX  160 AR7 VAL I  475  ASP I  481  1                                   7    
HELIX  161 AR8 ASN I  495  ASN I  503  1                                   9    
HELIX  162 AR9 SER I  505  SER I  510  1                                   6    
HELIX  163 AS1 SER I  521  MET I  548  1                                  28    
HELIX  164 AS2 SER I  672  VAL I  674  5                                   3    
HELIX  165 AS3 ASP I  679  TYR I  683  5                                   5    
HELIX  166 AS4 LEU J    3  GLN J   17  1                                  15    
HELIX  167 AS5 GLN J   18  ARG J   34  1                                  17    
HELIX  168 AS6 GLU J   36  THR J   50  1                                  15    
HELIX  169 AS7 GLN J   52  ARG J   63  1                                  12    
HELIX  170 AS8 LYS J   64  GLU J   70  1                                   7    
HELIX  171 AS9 GLU J   70  LYS J   84  1                                  15    
HELIX  172 AT1 GLN J   88  ASP J   94  1                                   7    
HELIX  173 AT2 GLN J  125  ASP J  144  1                                  20    
HELIX  174 AT3 ASN J  145  VAL J  161  1                                  17    
HELIX  175 AT4 CYS J  163  HIS J  173  1                                  11    
HELIX  176 AT5 THR J  177  LEU J  188  1                                  12    
HELIX  177 AT6 CYS J  194  LYS J  208  1                                  15    
HELIX  178 AT7 ASN J  230  CYS J  245  1                                  16    
HELIX  179 AT8 ASP J  246  ASP J  261  1                                  16    
HELIX  180 AT9 SER J  266  ASN J  279  1                                  14    
HELIX  181 AU1 LYS J  280  TYR J  295  1                                  16    
HELIX  182 AU2 ASN J  298  GLY J  313  1                                  16    
HELIX  183 AU3 LYS J  315  GLU J  330  1                                  16    
HELIX  184 AU4 TYR J  333  SER J  348  1                                  16    
HELIX  185 AU5 GLU J  349  MET J  364  1                                  16    
HELIX  186 AU6 HIS J  368  THR J  381  1                                  14    
HELIX  187 AU7 ASN J  383  ILE J  397  1                                  15    
HELIX  188 AU8 ASP J  401  GLY J  416  1                                  16    
HELIX  189 AU9 TRP J  418  ALA J  434  1                                  17    
HELIX  190 AV1 TRP J  444  LYS J  459  1                                  16    
HELIX  191 AV2 LYS J  460  ILE J  475  1                                  16    
HELIX  192 AV3 ASN J  478  MET J  492  1                                  15    
HELIX  193 AV4 ASN J  494  ARG J  509  1                                  16    
HELIX  194 AV5 ASP J  512  ASP J  529  1                                  18    
HELIX  195 AV6 LEU K    3  GLN K   17  1                                  15    
HELIX  196 AV7 GLN K   18  ARG K   34  1                                  17    
HELIX  197 AV8 GLU K   36  THR K   50  1                                  15    
HELIX  198 AV9 GLN K   52  SER K   62  1                                  11    
HELIX  199 AW1 LYS K   64  TYR K   69  1                                   6    
HELIX  200 AW2 TYR K   69  LYS K   84  1                                  16    
HELIX  201 AW3 GLN K   88  LEU K   93  1                                   6    
HELIX  202 AW4 SER K  130  ASP K  144  1                                  15    
HELIX  203 AW5 ASN K  145  VAL K  161  1                                  17    
HELIX  204 AW6 CYS K  163  SER K  172  1                                  10    
HELIX  205 AW7 HIS K  173  MET K  175  5                                   3    
HELIX  206 AW8 ALA K  178  LEU K  188  1                                  11    
HELIX  207 AW9 CYS K  194  LYS K  211  1                                  18    
HELIX  208 AX1 THR K  218  ASP K  225  1                                   8    
HELIX  209 AX2 GLY K  226  GLU K  229  5                                   4    
HELIX  210 AX3 ASN K  230  CYS K  245  1                                  16    
HELIX  211 AX4 ASP K  246  ASP K  261  1                                  16    
HELIX  212 AX5 SER K  266  ASN K  279  1                                  14    
HELIX  213 AX6 LYS K  280  TYR K  295  1                                  16    
HELIX  214 AX7 ASN K  298  GLY K  313  1                                  16    
HELIX  215 AX8 LYS K  315  GLU K  330  1                                  16    
HELIX  216 AX9 GLY K  334  SER K  348  1                                  15    
HELIX  217 AY1 GLU K  349  MET K  364  1                                  16    
HELIX  218 AY2 CYS K  367  THR K  381  1                                  15    
HELIX  219 AY3 ASN K  383  ALA K  398  1                                  16    
HELIX  220 AY4 ASP K  401  GLY K  416  1                                  16    
HELIX  221 AY5 GLU K  417  ILE K  435  1                                  19    
HELIX  222 AY6 THR K  440  LYS K  459  1                                  20    
HELIX  223 AY7 LYS K  460  ILE K  475  1                                  16    
HELIX  224 AY8 ASN K  478  MET K  492  1                                  15    
HELIX  225 AY9 ASN K  494  ARG K  509  1                                  16    
HELIX  226 AZ1 ASP K  512  ILE K  527  1                                  16    
HELIX  227 AZ2 ASP L   12  THR L   19  1                                   8    
HELIX  228 AZ3 GLY L   41  ARG L   46  1                                   6    
HELIX  229 AZ4 THR L  174  MET L  179  1                                   6    
HELIX  230 AZ5 ASP M    8  ASP M   16  1                                   9    
HELIX  231 AZ6 SER M   49  LYS M   56  1                                   8    
HELIX  232 AZ7 ALA N   16  ARG N   28  1                                  13    
HELIX  233 AZ8 VAL N   54  ALA N   63  1                                  10    
HELIX  234 AZ9 VAL N   78  TRP N   92  1                                  15    
HELIX  235 BA1 ALA N   94  GLU N   99  1                                   6    
HELIX  236 BA2 LEU N  108  ASP N  123  1                                  16    
HELIX  237 BA3 ASP N  123  GLY N  139  1                                  17    
HELIX  238 BA4 LEU N  149  PHE N  162  1                                  14    
HELIX  239 BA5 PRO N  166  GLY N  191  1                                  26    
HELIX  240 BA6 LEU N  203  LEU N  215  1                                  13    
HELIX  241 BA7 ARG N  234  LEU N  250  1                                  17    
HELIX  242 BA8 LEU N  252  ARG N  278  1                                  27    
HELIX  243 BA9 ARG N  287  PHE N  304  1                                  18    
HELIX  244 BB1 TRP N  324  ARG N  349  1                                  26    
HELIX  245 BB2 SER N  354  ARG N  367  1                                  14    
HELIX  246 BB3 GLN N  370  LEU N  386  1                                  17    
HELIX  247 BB4 ASP N  395  VAL N  409  1                                  15    
HELIX  248 BB5 ILE N  416  CYS N  421  1                                   6    
HELIX  249 BB6 CYS N  421  GLU N  432  1                                  12    
HELIX  250 BB7 ASP N  433  LEU N  442  1                                  10    
HELIX  251 BB8 SER N  452  ASP N  458  1                                   7    
HELIX  252 BB9 SER N  499  TYR N  509  1                                  11    
HELIX  253 BC1 LYS N  512  GLN N  530  1                                  19    
HELIX  254 BC2 GLU N  536  PHE N  549  1                                  14    
HELIX  255 BC3 MET N  554  ASP N  563  1                                  10    
HELIX  256 BC4 ALA N  565  LYS N  580  1                                  16    
HELIX  257 BC5 PRO N  612  LEU N  629  1                                  18    
HELIX  258 BC6 LYS N  638  GLY N  642  5                                   5    
HELIX  259 BC7 THR N  660  ASP N  672  1                                  13    
HELIX  260 BC8 THR N  677  LYS N  686  1                                  10    
HELIX  261 BC9 PRO N  688  GLY N  703  1                                  16    
HELIX  262 BD1 GLU N  748  GLU N  766  1                                  19    
HELIX  263 BD2 SER N  769  VAL N  781  1                                  13    
HELIX  264 BD3 ASP N  791  ASP N  805  1                                  15    
HELIX  265 BD4 THR O   31  SER O   45  1                                  15    
HELIX  266 BD5 SER O   53  GLY O   70  1                                  18    
HELIX  267 BD6 THR O   74  CYS O   86  1                                  13    
HELIX  268 BD7 CYS O   86  GLY O  103  1                                  18    
HELIX  269 BD8 GLU O  104  GLY O  121  1                                  18    
HELIX  270 BD9 THR O  129  LEU O  146  1                                  18    
HELIX  271 BE1 SER O  147  THR O  169  1                                  23    
HELIX  272 BE2 SER O  208  ASP O  226  1                                  19    
HELIX  273 BE3 THR O  232  ASN O  247  1                                  16    
HELIX  274 BE4 ALA O  251  GLN O  265  1                                  15    
HELIX  275 BE5 ASP O  266  LEU O  281  1                                  16    
HELIX  276 BE6 ARG O  298  PHE O  314  1                                  17    
HELIX  277 BE7 HIS O  316  ASN O  335  1                                  20    
HELIX  278 BE8 ASP O  336  GLY O  351  1                                  16    
HELIX  279 BE9 SER O  357  HIS O  370  1                                  14    
HELIX  280 BF1 LEU O  373  GLY O  392  1                                  20    
HELIX  281 BF2 THR O  394  SER O  413  1                                  20    
HELIX  282 BF3 LEU O  414  TYR O  432  1                                  19    
HELIX  283 BF4 ARG O  434  MET O  448  1                                  15    
HELIX  284 BF5 ASN O  462  GLN O  480  1                                  19    
HELIX  285 BF6 CYS O  482  PHE O  497  1                                  16    
HELIX  286 BF7 HIS O  503  GLY O  523  1                                  21    
HELIX  287 BF8 LYS O  524  SER O  540  1                                  17    
HELIX  288 BF9 SER O  540  GLN O  554  1                                  15    
HELIX  289 BG1 GLN O  556  LYS O  575  1                                  20    
HELIX  290 BG2 ASN O  576  SER O  594  1                                  19    
HELIX  291 BG3 SER O  596  THR O  598  5                                   3    
HELIX  292 BG4 ILE O  599  TYR O  614  1                                  16    
HELIX  293 BG5 LEU O  616  GLY O  635  1                                  20    
HELIX  294 BG6 ILE O  636  ASP O  654  1                                  19    
HELIX  295 BG7 ILE O  657  TYR O  678  1                                  22    
HELIX  296 BG8 LYS O  682  ASP O  705  1                                  24    
HELIX  297 BG9 LYS O  707  GLY O  725  1                                  19    
HELIX  298 BH1 LYS O  726  HIS O  741  1                                  16    
HELIX  299 BH2 ASP P   28  GLY P   47  1                                  20    
HELIX  300 BH3 LEU P   48  LEU P   62  1                                  15    
HELIX  301 BH4 THR P   77  LYS P   97  1                                  21    
HELIX  302 BH5 GLU P   98  LEU P  106  1                                   9    
HELIX  303 BH6 HIS P  107  CYS P  109  5                                   3    
HELIX  304 BH7 SER P  111  THR P  134  1                                  24    
HELIX  305 BH8 ASN P  148  ARG P  165  1                                  18    
HELIX  306 BH9 GLY P  169  LEU P  182  1                                  14    
HELIX  307 BI1 LEU P  184  LEU P  199  1                                  16    
HELIX  308 BI2 HIS P  202  ILE P  213  1                                  12    
HELIX  309 BI3 ASP P  215  LEU P  222  1                                   8    
HELIX  310 BI4 TRP P  228  LEU P  241  1                                  14    
HELIX  311 BI5 LEU P  243  VAL P  257  1                                  15    
HELIX  312 BI6 SER P  262  ILE P  276  1                                  15    
HELIX  313 BI7 ASP P  278  ASP P  293  1                                  16    
HELIX  314 BI8 ASN P  299  ARG P  310  1                                  12    
HELIX  315 BI9 MET P  312  ASP P  327  1                                  16    
HELIX  316 BJ1 ARG P  330  ARG P  344  1                                  15    
HELIX  317 BJ2 GLN P  346  ASN P  361  1                                  16    
HELIX  318 BJ3 TYR P  364  MET P  378  1                                  15    
HELIX  319 BJ4 ASN P  380  ASN P  395  1                                  16    
HELIX  320 BJ5 ASP P  398  LEU P  412  1                                  15    
HELIX  321 BJ6 PRO P  415  ARG P  429  1                                  15    
HELIX  322 BJ7 ASP P  432  ASN P  447  1                                  16    
HELIX  323 BJ8 GLN P  448  GLY P  463  1                                  16    
HELIX  324 BJ9 MET P  468  LEU P  480  1                                  13    
HELIX  325 BK1 GLU P  482  CYS P  500  1                                  19    
HELIX  326 BK2 ALA P  512  CYS P  523  1                                  12    
HELIX  327 BK3 LEU P  525  ALA P  538  1                                  14    
HELIX  328 BK4 PRO Q  409  TYR Q  411  5                                   3    
HELIX  329 BK5 SER R   84  LYS R   97  1                                  14    
HELIX  330 BK6 THR R  108  ASN R  121  1                                  14    
HELIX  331 BK7 PRO R  409  TYR R  411  5                                   3    
HELIX  332 BK8 ASP S   20  LYS S   26  1                                   7    
HELIX  333 BK9 GLU S   27  VAL S   29  5                                   3    
HELIX  334 BL1 ILE S   37  ALA S   46  1                                  10    
HELIX  335 BL2 ALA S   50  GLY S   71  1                                  22    
HELIX  336 BL3 VAL S   77  TYR S   89  1                                  13    
HELIX  337 BL4 ASN S   97  GLN S  110  1                                  14    
HELIX  338 BL5 GLU S  112  TYR S  116  5                                   5    
HELIX  339 BL6 ASP S  118  ARG S  130  1                                  13    
HELIX  340 BL7 PRO S  135  GLY S  146  1                                  12    
HELIX  341 BL8 LEU S  151  ARG S  165  1                                  15    
HELIX  342 BL9 ASN S  167  GLN S  181  1                                  15    
HELIX  343 BM1 PRO S  185  ALA S  207  1                                  23    
HELIX  344 BM2 LEU S  287  VAL S  292  1                                   6    
HELIX  345 BM3 LYS W   12  ASP W   25  1                                  14    
HELIX  346 BM4 VAL X   37  GLY X   48  1                                  12    
HELIX  347 BM5 LEU X   49  ASN X   67  1                                  19    
HELIX  348 BM6 SER X   72  LYS X   91  1                                  20    
HELIX  349 BM7 GLU X   92  LEU X  110  1                                  19    
HELIX  350 BM8 SER X  134  LYS X  150  1                                  17    
HELIX  351 BM9 GLN X  151  ILE X  162  1                                  12    
HELIX  352 BN1 THR X  168  GLY X  183  1                                  16    
HELIX  353 BN2 GLN X  184  CYS X  199  1                                  16    
HELIX  354 BN3 ALA X  202  SER X  213  1                                  12    
HELIX  355 BN4 VAL X  214  THR X  229  1                                  16    
HELIX  356 BN5 TRP X  235  GLY X  249  1                                  15    
HELIX  357 BN6 ASP X  250  LYS X  264  1                                  15    
HELIX  358 BN7 ASN X  270  GLY X  285  1                                  16    
HELIX  359 BN8 ASP X  286  ASP X  301  1                                  16    
HELIX  360 BN9 LEU X  304  GLY X  319  1                                  16    
HELIX  361 BO1 ARG X  320  SER X  335  1                                  16    
HELIX  362 BO2 HIS X  338  LYS X  353  1                                  16    
HELIX  363 BO3 ARG X  354  ASN X  369  1                                  16    
HELIX  364 BO4 VAL X  373  GLY X  387  1                                  15    
HELIX  365 BO5 ARG X  388  ALA X  403  1                                  16    
HELIX  366 BO6 ARG X  406  ASN X  421  1                                  16    
HELIX  367 BO7 SER X  422  GLY X  438  1                                  17    
HELIX  368 BO8 ALA X  441  ASP X  454  1                                  14    
HELIX  369 BO9 THR X  457  ARG X  472  1                                  16    
HELIX  370 BP1 TYR X  475  GLN X  490  1                                  16    
HELIX  371 BP2 TYR X  492  GLN X  506  1                                  15    
HELIX  372 BP3 CYS X  509  ASN X  523  1                                  15    
HELIX  373 BP4 GLU X  524  ASP X  539  1                                  16    
HELIX  374 BP5 VAL Y   37  GLY Y   48  1                                  12    
HELIX  375 BP6 LEU Y   49  ASN Y   67  1                                  19    
HELIX  376 BP7 SER Y   72  LYS Y   91  1                                  20    
HELIX  377 BP8 GLU Y   92  LEU Y  110  1                                  19    
HELIX  378 BP9 SER Y  134  LYS Y  150  1                                  17    
HELIX  379 BQ1 GLN Y  151  ILE Y  162  1                                  12    
HELIX  380 BQ2 THR Y  168  GLY Y  183  1                                  16    
HELIX  381 BQ3 GLN Y  184  CYS Y  199  1                                  16    
HELIX  382 BQ4 ALA Y  202  SER Y  213  1                                  12    
HELIX  383 BQ5 VAL Y  214  THR Y  229  1                                  16    
HELIX  384 BQ6 TRP Y  235  GLY Y  249  1                                  15    
HELIX  385 BQ7 ASP Y  250  LYS Y  264  1                                  15    
HELIX  386 BQ8 ASN Y  270  GLY Y  285  1                                  16    
HELIX  387 BQ9 ASP Y  286  ASP Y  301  1                                  16    
HELIX  388 BR1 LEU Y  304  GLY Y  319  1                                  16    
HELIX  389 BR2 ARG Y  320  SER Y  335  1                                  16    
HELIX  390 BR3 HIS Y  338  LYS Y  353  1                                  16    
HELIX  391 BR4 ARG Y  354  ASN Y  369  1                                  16    
HELIX  392 BR5 SER Y  372  GLY Y  387  1                                  16    
HELIX  393 BR6 ARG Y  388  ALA Y  403  1                                  16    
HELIX  394 BR7 ARG Y  406  ASN Y  421  1                                  16    
HELIX  395 BR8 SER Y  422  GLY Y  438  1                                  17    
HELIX  396 BR9 ALA Y  441  ASP Y  454  1                                  14    
HELIX  397 BS1 THR Y  457  ARG Y  472  1                                  16    
HELIX  398 BS2 TYR Y  475  GLN Y  490  1                                  16    
HELIX  399 BS3 TYR Y  492  GLN Y  506  1                                  15    
HELIX  400 BS4 CYS Y  509  ASN Y  523  1                                  15    
HELIX  401 BS5 GLU Y  524  ASP Y  539  1                                  16    
HELIX  402 BS6 ASP Y  542  LYS Y  551  1                                  10    
HELIX  403 BS7 THR Z   12  ARG Z   35  1                                  24    
HELIX  404 BS8 PRO Z   39  GLU Z   41  5                                   3    
HELIX  405 BS9 ASP Z   58  LYS Z   78  1                                  21    
HELIX  406 BT1 THR Z  109  ASP Z  113  5                                   5    
HELIX  407 BT2 SER Z  120  THR Z  138  1                                  19    
SHEET    1 AA1 4 LEU A  17  PHE A  20  0                                        
SHEET    2 AA1 4 MET A 604  THR A 608 -1  O  MET A 604   N  PHE A  20           
SHEET    3 AA1 4 ARG A 594  LEU A 599 -1  N  VAL A 595   O  ILE A 607           
SHEET    4 AA1 4 ILE A 584  VAL A 591 -1  N  ARG A 588   O  THR A 596           
SHEET    1 AA2 4 SER A  73  LYS A  78  0                                        
SHEET    2 AA2 4 ASP A  90  VAL A  95 -1  O  VAL A  95   N  SER A  73           
SHEET    3 AA2 4 MET A  99  SER A 103 -1  O  ILE A 101   N  TYR A  94           
SHEET    4 AA2 4 VAL A 113  THR A 118 -1  O  PHE A 117   N  VAL A 100           
SHEET    1 AA3 4 LEU A 127  ILE A 132  0                                        
SHEET    2 AA3 4 VAL A 147  LEU A 154 -1  O  CYS A 152   N  LEU A 127           
SHEET    3 AA3 4 CYS A 158  SER A 163 -1  O  ASN A 160   N  ILE A 153           
SHEET    4 AA3 4 ASP A 168  SER A 172 -1  O  TYR A 169   N  MET A 161           
SHEET    1 AA4 4 VAL A 177  VAL A 180  0                                        
SHEET    2 AA4 4 LEU A 187  ARG A 191 -1  O  GLU A 190   N  ALA A 178           
SHEET    3 AA4 4 MET A 210  MET A 213 -1  O  PHE A 211   N  PHE A 189           
SHEET    4 AA4 4 THR A 221  PRO A 222 -1  O  THR A 221   N  SER A 212           
SHEET    1 AA5 2 VAL A 224  CYS A 225  0                                        
SHEET    2 AA5 2 GLN A 237  TYR A 238 -1  O  GLN A 237   N  CYS A 225           
SHEET    1 AA6 4 LYS A 245  ASN A 250  0                                        
SHEET    2 AA6 4 ILE A 255  ASP A 260 -1  O  MET A 257   N  PHE A 248           
SHEET    3 AA6 4 VAL A 265  TRP A 269 -1  O  SER A 267   N  THR A 258           
SHEET    4 AA6 4 HIS A 411  TRP A 413 -1  O  LEU A 412   N  VAL A 268           
SHEET    1 AA7 4 ALA A 427  SER A 434  0                                        
SHEET    2 AA7 4 LYS A 440  VAL A 446 -1  O  PHE A 441   N  THR A 433           
SHEET    3 AA7 4 GLN A 451  GLU A 459 -1  O  ARG A 453   N  PHE A 444           
SHEET    4 AA7 4 LEU A 466  ILE A 474 -1  O  ILE A 474   N  LEU A 452           
SHEET    1 AA8 4 ASP A 478  VAL A 482  0                                        
SHEET    2 AA8 4 THR A 487  GLU A 492 -1  O  LEU A 489   N  ALA A 480           
SHEET    3 AA8 4 ASN A 496  TYR A 500 -1  O  VAL A 498   N  VAL A 490           
SHEET    4 AA8 4 ARG A 505  LYS A 508 -1  O  VAL A 506   N  LEU A 499           
SHEET    1 AA9 2 GLY A1109  ALA A1111  0                                        
SHEET    2 AA9 2 THR A1116  VAL A1118 -1  O  VAL A1118   N  GLY A1109           
SHEET    1 AB1 2 TYR A1572  LEU A1574  0                                        
SHEET    2 AB1 2 ALA A1614  PRO A1616 -1  O  GLU A1615   N  SER A1573           
SHEET    1 AB2 3 THR A1655  LEU A1656  0                                        
SHEET    2 AB2 3 LEU A1618  VAL A1622 -1  N  LEU A1619   O  THR A1655           
SHEET    3 AB2 3 VAL A1696  TYR A1698  1  O  LEU A1697   N  VAL A1620           
SHEET    1 AB3 4 GLN A1646  MET A1652  0                                        
SHEET    2 AB3 4 LEU A1633  LYS A1639 -1  N  VAL A1636   O  GLU A1649           
SHEET    3 AB3 4 LEU A1663  VAL A1668 -1  O  LYS A1667   N  GLU A1635           
SHEET    4 AB3 4 GLU A1675  ILE A1678 -1  O  LEU A1677   N  ILE A1666           
SHEET    1 AB4 3 VAL B   3  LYS B   4  0                                        
SHEET    2 AB4 3 ASP N 647  VAL N 648 -1  O  ASP N 647   N  LYS B   4           
SHEET    3 AB4 3 LEU N 655  SER N 656 -1  O  LEU N 655   N  VAL N 648           
SHEET    1 AB5 3 CYS B  54  HIS B  56  0                                        
SHEET    2 AB5 3 LEU B  46  GLY B  49 -1  N  VAL B  47   O  PHE B  55           
SHEET    3 AB5 3 PHE B  82  GLU B  84 -1  O  GLU B  84   N  TRP B  48           
SHEET    1 AB6 4 ILE I  23  TRP I  28  0                                        
SHEET    2 AB6 4 ILE I  35  ASN I  39 -1  O  ALA I  38   N  PHE I  25           
SHEET    3 AB6 4 VAL I  44  HIS I  47 -1  O  HIS I  47   N  ILE I  35           
SHEET    4 AB6 4 ARG I  54  PHE I  58 -1  O  VAL I  55   N  LEU I  46           
SHEET    1 AB7 4 VAL I  68  LEU I  71  0                                        
SHEET    2 AB7 4 LEU I  79  LEU I  84 -1  O  ALA I  83   N  CYS I  70           
SHEET    3 AB7 4 ILE I  90  ASP I  94 -1  O  VAL I  91   N  PHE I  82           
SHEET    4 AB7 4 SER I 103  PHE I 104 -1  O  PHE I 104   N  ILE I  90           
SHEET    1 AB8 2 CYS I 112  GLU I 117  0                                        
SHEET    2 AB8 2 ASN I 174  GLY I 179 -1  O  GLY I 179   N  CYS I 112           
SHEET    1 AB9 2 PHE I 184  ALA I 189  0                                        
SHEET    2 AB9 2 PHE I 193  THR I 199 -1  O  VAL I 198   N  ILE I 185           
SHEET    1 AC1 4 THR I 204  LEU I 210  0                                        
SHEET    2 AC1 4 SER I 216  GLU I 222 -1  O  GLU I 222   N  THR I 204           
SHEET    3 AC1 4 TYR I 233  GLU I 237 -1  O  PHE I 234   N  VAL I 219           
SHEET    4 AC1 4 ALA I 551  ILE I 554 -1  O  ILE I 552   N  GLN I 235           
SHEET    1 AC2 2 SER I 229  GLU I 230  0                                        
SHEET    2 AC2 2 ARG I 558  ASP I 559 -1  O  ASP I 559   N  SER I 229           
SHEET    1 AC3 5 PHE I 574  ASN I 578  0                                        
SHEET    2 AC3 5 LEU I 583  LEU I 591 -1  O  TYR I 585   N  TRP I 576           
SHEET    3 AC3 5 TYR I 596  HIS I 604 -1  O  CYS I 599   N  PHE I 588           
SHEET    4 AC3 5 LEU I 615  THR I 624 -1  O  ILE I 616   N  ILE I 600           
SHEET    5 AC3 5 VAL I 631  ARG I 632 -1  O  ARG I 632   N  PHE I 623           
SHEET    1 AC4 5 PHE I 574  ASN I 578  0                                        
SHEET    2 AC4 5 LEU I 583  LEU I 591 -1  O  TYR I 585   N  TRP I 576           
SHEET    3 AC4 5 TYR I 596  HIS I 604 -1  O  CYS I 599   N  PHE I 588           
SHEET    4 AC4 5 LEU I 615  THR I 624 -1  O  ILE I 616   N  ILE I 600           
SHEET    5 AC4 5 THR I 702  PHE I 707  1  O  PHE I 707   N  SER I 622           
SHEET    1 AC5 4 TYR I 636  ASP I 645  0                                        
SHEET    2 AC5 4 THR I 648  ASP I 655 -1  O  LYS I 654   N  SER I 637           
SHEET    3 AC5 4 ARG I 664  PRO I 670 -1  O  VAL I 667   N  VAL I 651           
SHEET    4 AC5 4 TRP I 711  LEU I 714 -1  O  LEU I 714   N  ARG I 664           
SHEET    1 AC6 3 ALA I 719  GLY I 724  0                                        
SHEET    2 AC6 3 VAL I 730  SER I 735 -1  O  LEU I 734   N  TYR I 721           
SHEET    3 AC6 3 VAL I 741  GLU I 745 -1  O  ARG I 742   N  VAL I 733           
SHEET    1 AC7 4 VAL L  22  GLU L  24  0                                        
SHEET    2 AC7 4 GLN L 155  PRO L 161 -1  O  THR L 160   N  ARG L  23           
SHEET    3 AC7 4 THR L  76  TYR L  80 -1  N  CYS L  78   O  LYS L 157           
SHEET    4 AC7 4 TRP L 119  PRO L 123 -1  O  VAL L 122   N  LEU L  77           
SHEET    1 AC8 5 VAL L  30  LEU L  33  0                                        
SHEET    2 AC8 5 HIS L  62  VAL L  74 -1  O  ASN L  65   N  SER L  32           
SHEET    3 AC8 5 THR L 132  VAL L 141 -1  O  VAL L 141   N  HIS L  62           
SHEET    4 AC8 5 LYS L  93  GLY L  99 -1  N  SER L  95   O  ALA L 140           
SHEET    5 AC8 5 GLN L 106  GLU L 112 -1  O  LEU L 111   N  ILE L  94           
SHEET    1 AC9 2 TRP L  54  GLN L  55  0                                        
SHEET    2 AC9 2 HIS L 152  MET L 153 -1  O  MET L 153   N  TRP L  54           
SHEET    1 AD1 3 SER N 767  LEU N 768  0                                        
SHEET    2 AD1 3 VAL N 814  ARG N 816 -1  O  TYR N 815   N  LEU N 768           
SHEET    3 AD1 3 VAL N 809  SER N 811 -1  N  VAL N 809   O  ARG N 816           
SHEET    1 AD2 7 TRP Z 167  GLU Z 169  0                                        
SHEET    2 AD2 7 ALA Q 128  LEU Q 133 -1  N  ARG Q 132   O  GLU Z 168           
SHEET    3 AD2 7 CYS Z 149  ASP Z 158 -1  O  ILE Z 155   N  LEU Q 131           
SHEET    4 AD2 7 VAL Z  81  ASN Z  90 -1  N  VAL Z  85   O  LEU Z 154           
SHEET    5 AD2 7 VAL Z  96  CYS Z 106 -1  O  ILE Z 104   N  GLN Z  82           
SHEET    6 AD2 7 HIS Z 191  LYS Z 200 -1  O  LYS Z 192   N  GLU Z 105           
SHEET    7 AD2 7 SER Z 178  THR Z 187 -1  N  VAL Z 181   O  VAL Z 197           
SHEET    1 AD3 4 ARG Q 174  ASP Q 177  0                                        
SHEET    2 AD3 4 THR Q 466  ARG Q 471 -1  O  LEU Q 467   N  LEU Q 176           
SHEET    3 AD3 4 THR Q 457  ALA Q 462 -1  N  VAL Q 458   O  TRP Q 470           
SHEET    4 AD3 4 VAL Q 446  MET Q 451 -1  N  THR Q 450   O  ALA Q 459           
SHEET    1 AD4 4 VAL Q 190  TRP Q 192  0                                        
SHEET    2 AD4 4 VAL Q 197  LEU Q 202 -1  O  ALA Q 199   N  ASP Q 191           
SHEET    3 AD4 4 SER Q 205  SER Q 210 -1  O  TYR Q 207   N  VAL Q 200           
SHEET    4 AD4 4 ILE Q 216  GLN Q 221 -1  O  LEU Q 217   N  LEU Q 208           
SHEET    1 AD5 4 ILE Q 229  TRP Q 234  0                                        
SHEET    2 AD5 4 TYR Q 240  THR Q 245 -1  O  ALA Q 242   N  ALA Q 233           
SHEET    3 AD5 4 GLU Q 249  ASP Q 254 -1  O  GLN Q 251   N  VAL Q 243           
SHEET    4 AD5 4 LYS Q 259  THR Q 265 -1  O  LEU Q 261   N  LEU Q 252           
SHEET    1 AD6 4 SER Q 273  ASN Q 277  0                                        
SHEET    2 AD6 4 ILE Q 280  GLY Q 284 -1  O  SER Q 282   N  SER Q 275           
SHEET    3 AD6 4 HIS Q 289  ASP Q 294 -1  O  HIS Q 293   N  LEU Q 281           
SHEET    4 AD6 4 HIS Q 301  SER Q 306 -1  O  LEU Q 305   N  ILE Q 290           
SHEET    1 AD7 4 VAL Q 312  TRP Q 317  0                                        
SHEET    2 AD7 4 HIS Q 323  GLY Q 328 -1  O  ALA Q 325   N  ARG Q 316           
SHEET    3 AD7 4 VAL Q 333  PRO Q 337 -1  O  TRP Q 336   N  LEU Q 324           
SHEET    4 AD7 4 GLN Q 349  PHE Q 351 -1  O  GLN Q 349   N  VAL Q 335           
SHEET    1 AD8 4 VAL Q 358  TRP Q 363  0                                        
SHEET    2 AD8 4 VAL Q 370  GLY Q 375 -1  O  ALA Q 372   N  ALA Q 362           
SHEET    3 AD8 4 HIS Q 381  ASN Q 386 -1  O  TRP Q 385   N  LEU Q 371           
SHEET    4 AD8 4 CYS Q 392  ASP Q 397 -1  O  VAL Q 396   N  ILE Q 382           
SHEET    1 AD9 4 VAL Q 402  SER Q 408  0                                        
SHEET    2 AD9 4 GLU Q 413  HIS Q 418 -1  O  GLU Q 413   N  SER Q 408           
SHEET    3 AD9 4 LEU Q 425  LYS Q 429 -1  O  TRP Q 428   N  LEU Q 414           
SHEET    4 AD9 4 ALA Q 434  LEU Q 439 -1  O  LEU Q 439   N  LEU Q 425           
SHEET    1 AE1 4 ARG R 174  ASP R 177  0                                        
SHEET    2 AE1 4 THR R 466  ARG R 471 -1  O  LEU R 467   N  LEU R 176           
SHEET    3 AE1 4 THR R 457  ALA R 462 -1  N  VAL R 458   O  TRP R 470           
SHEET    4 AE1 4 VAL R 446  MET R 451 -1  N  THR R 450   O  ALA R 459           
SHEET    1 AE2 4 VAL R 190  TRP R 192  0                                        
SHEET    2 AE2 4 VAL R 197  LEU R 202 -1  O  ALA R 199   N  ASP R 191           
SHEET    3 AE2 4 SER R 205  SER R 210 -1  O  TYR R 207   N  VAL R 200           
SHEET    4 AE2 4 ILE R 216  GLN R 221 -1  O  LEU R 217   N  LEU R 208           
SHEET    1 AE3 4 ILE R 229  TRP R 234  0                                        
SHEET    2 AE3 4 TYR R 240  THR R 245 -1  O  ALA R 242   N  ALA R 233           
SHEET    3 AE3 4 GLU R 249  ASP R 254 -1  O  GLN R 251   N  VAL R 243           
SHEET    4 AE3 4 LYS R 259  THR R 265 -1  O  LYS R 259   N  ASP R 254           
SHEET    1 AE4 4 SER R 273  ASN R 277  0                                        
SHEET    2 AE4 4 ILE R 280  GLY R 284 -1  O  SER R 282   N  SER R 275           
SHEET    3 AE4 4 HIS R 289  ASP R 294 -1  O  HIS R 293   N  LEU R 281           
SHEET    4 AE4 4 HIS R 301  SER R 306 -1  O  LEU R 305   N  ILE R 290           
SHEET    1 AE5 4 VAL R 312  TRP R 317  0                                        
SHEET    2 AE5 4 HIS R 323  GLY R 328 -1  O  ALA R 325   N  ARG R 316           
SHEET    3 AE5 4 VAL R 333  PRO R 337 -1  O  TRP R 336   N  LEU R 324           
SHEET    4 AE5 4 GLN R 349  PHE R 351 -1  O  GLN R 349   N  VAL R 335           
SHEET    1 AE6 4 ALA R 360  TRP R 363  0                                        
SHEET    2 AE6 4 VAL R 370  GLY R 374 -1  O  ALA R 372   N  ALA R 362           
SHEET    3 AE6 4 HIS R 381  ASN R 386 -1  O  TRP R 385   N  LEU R 371           
SHEET    4 AE6 4 CYS R 392  ASP R 397 -1  O  VAL R 396   N  ILE R 382           
SHEET    1 AE7 4 VAL R 402  SER R 408  0                                        
SHEET    2 AE7 4 GLU R 413  HIS R 418 -1  O  GLU R 413   N  SER R 408           
SHEET    3 AE7 4 LEU R 425  LYS R 429 -1  O  TRP R 428   N  LEU R 414           
SHEET    4 AE7 4 ALA R 434  LEU R 439 -1  O  LEU R 439   N  LEU R 425           
SHEET    1 AE8 2 PHE Z  43  LYS Z  48  0                                        
SHEET    2 AE8 2 LEU Z  51  THR Z  56 -1  O  LEU Z  53   N  VAL Z  46           
SSBOND   1 CYS B   23    CYS B   26                          1555   1555  2.03  
SSBOND   2 CYS B   34    CYS B   44                          1555   1555  2.04  
SSBOND   3 CYS Z   79    CYS Z  106                          1555   1555  2.02  
CISPEP   1 LEU A 1100    PRO A 1101          0       -12.13                     
CISPEP   2 PRO A 1112    PRO A 1113          0        -0.18                     
CISPEP   3 GLY A 1670    PRO A 1671          0        -0.23                     
CISPEP   4 SER A 1739    ALA A 1740          0        17.11                     
CISPEP   5 TRP B   14    LEU B   15          0         2.51                     
CISPEP   6 VAL C   96    LYS C   97          0        19.48                     
CISPEP   7 ASN C  361    PRO C  362          0       -11.68                     
CISPEP   8 ASN F  145    PRO F  146          0        -6.64                     
CISPEP   9 ASN H  145    PRO H  146          0        -7.53                     
CISPEP  10 LEU I  437    ASN I  438          0        -4.89                     
CISPEP  11 PRO I  489    PRO I  490          0        15.29                     
CISPEP  12 PHE I  572    PRO I  573          0         0.13                     
CISPEP  13 GLN L   60    PRO L   61          0        -1.14                     
CISPEP  14 THR L  125    ASP L  126          0       -14.43                     
CISPEP  15 PRO L  170    ARG L  171          0        -5.72                     
CISPEP  16 ALA N   63    ALA N   64          0        23.88                     
CISPEP  17 TYR N  125    LEU N  126          0         9.37                     
CISPEP  18 THR N  165    PRO N  166          0       -19.88                     
CISPEP  19 PRO N  197    GLU N  198          0        -1.21                     
CISPEP  20 SER N  284    PHE N  285          0       -16.21                     
CISPEP  21 ASP N  350    PHE N  351          0       -26.19                     
CISPEP  22 THR N  368    ASP N  369          0        10.53                     
CISPEP  23 PRO N  477    GLU N  478          0        -2.69                     
CISPEP  24 GLU N  478    ASP N  479          0         5.99                     
CISPEP  25 ASP N  483    PRO N  484          0         8.48                     
CISPEP  26 PRO N  484    VAL N  485          0        -3.66                     
CISPEP  27 SER N  493    SER N  494          0        -3.25                     
CISPEP  28 TYR N  509    GLY N  510          0        -9.28                     
CISPEP  29 SER N  532    PHE N  533          0         0.18                     
CISPEP  30 GLY N  550    GLU N  551          0        -9.15                     
CISPEP  31 PRO N  709    PRO N  710          0        -3.91                     
CISPEP  32 GLU O  123    PRO O  124          0        -7.95                     
CISPEP  33 ASP O  356    SER O  357          0         5.19                     
CISPEP  34 VAL P   96    LYS P   97          0        18.78                     
CISPEP  35 ASN P  361    PRO P  362          0       -11.74                     
CISPEP  36 PHE Q  420    ALA Q  421          0         5.24                     
CISPEP  37 TYR Q  430    PRO Q  431          0        12.80                     
CISPEP  38 GLN Q  496    GLY Q  497          0        -3.19                     
CISPEP  39 PRO R   74    GLY R   75          0         9.10                     
CISPEP  40 LYS R   97    GLU R   98          0        -5.42                     
CISPEP  41 ASN R   99    GLN R  100          0         3.96                     
CISPEP  42 GLU R  127    ALA R  128          0        -1.56                     
CISPEP  43 PHE R  420    ALA R  421          0         4.12                     
CISPEP  44 TYR R  430    PRO R  431          0        13.07                     
CISPEP  45 CYS S  132    ASN S  133          0         4.12                     
CISPEP  46 GLU S  184    PRO S  185          0        -8.21                     
CISPEP  47 ALA S  279    ASP S  280          0        -8.75                     
CISPEP  48 CYS Y  199    PRO Y  200          0       -25.48                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           2          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.002785  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.002785  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.002785        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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