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Entry: 5LUQ
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HEADER    TRANSFERASE                             09-SEP-16   5LUQ              
TITLE     CRYSTAL STRUCTURE OF HUMAN DNA-DEPENDENT PROTEIN KINASE CATALYTIC     
TITLE    2 SUBUNIT (DNA-PKCS)                                                   
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT,DNA-        
COMPND   3 DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT,DNA-DEPENDENT PROTEIN     
COMPND   4 KINASE CATALYTIC SUBUNIT;                                            
COMPND   5 CHAIN: A, B;                                                         
COMPND   6 SYNONYM: DNA-PKCS,DNPK1,P460,DNA-PKCS,DNPK1,P460;                    
COMPND   7 EC: 2.7.11.1,2.7.11.1,2.7.11.1;                                      
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: C-TERMINAL FRAGMENT OF KU80 (KU80CT194);                   
COMPND  10 CHAIN: K, S;                                                         
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 CELL_LINE: HELA;                                                     
SOURCE   6 MOL_ID: 2;                                                           
SOURCE   7 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   8 ORGANISM_TAXID: 9606;                                                
SOURCE   9 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE  10 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  11 EXPRESSION_SYSTEM_PLASMID: PGAT3                                     
KEYWDS    DNA-PKCS, KINASE, DNA REPAIR, NHEJ, DOUBLE STRAND BREAK REPAIR, HEAT  
KEYWDS   2 REPEAT, TRANSFERASE                                                  
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    B.L.SIBANDA,D.Y.CHIRGADZE,D.B.ASCHER,T.L.BLUNDELL                     
REVDAT   3   28-MAR-18 5LUQ    1       SOURCE                                   
REVDAT   2   01-MAR-17 5LUQ    1       JRNL                                     
REVDAT   1   15-FEB-17 5LUQ    0                                                
JRNL        AUTH   B.L.SIBANDA,D.Y.CHIRGADZE,D.B.ASCHER,T.L.BLUNDELL            
JRNL        TITL   DNA-PKCS STRUCTURE SUGGESTS AN ALLOSTERIC MECHANISM          
JRNL        TITL 2 MODULATING DNA DOUBLE-STRAND BREAK REPAIR.                   
JRNL        REF    SCIENCE                       V. 355   520 2017              
JRNL        REFN                   ESSN 1095-9203                               
JRNL        PMID   28154079                                                     
JRNL        DOI    10.1126/SCIENCE.AAK9654                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.30 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (1.10_2155: ???)                              
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 4.30                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 49.92                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 0.000                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.8                           
REMARK   3   NUMBER OF REFLECTIONS             : 84530                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.387                           
REMARK   3   R VALUE            (WORKING SET) : 0.386                           
REMARK   3   FREE R VALUE                     : 0.437                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 2.340                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 1978                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 49.9234 - 10.3352    1.00     6190   152  0.3318 0.3788        
REMARK   3     2 10.3352 -  8.2152    1.00     6087   148  0.2844 0.3607        
REMARK   3     3  8.2152 -  7.1802    1.00     6061   144  0.3883 0.4546        
REMARK   3     4  7.1802 -  6.5253    1.00     6008   142  0.4413 0.4666        
REMARK   3     5  6.5253 -  6.0584    1.00     5986   147  0.4571 0.5304        
REMARK   3     6  6.0584 -  5.7018    0.99     6007   134  0.4628 0.4567        
REMARK   3     7  5.7018 -  5.4166    0.99     5941   140  0.4605 0.5191        
REMARK   3     8  5.4166 -  5.1810    0.99     5943   145  0.4549 0.5099        
REMARK   3     9  5.1810 -  4.9818    0.98     5859   135  0.4535 0.4999        
REMARK   3    10  4.9818 -  4.8100    0.97     5842   142  0.4617 0.4783        
REMARK   3    11  4.8100 -  4.6597    0.97     5782   140  0.4580 0.5102        
REMARK   3    12  4.6597 -  4.5266    0.96     5752   140  0.4477 0.5077        
REMARK   3    13  4.5266 -  4.4075    0.95     5631   135  0.4432 0.4963        
REMARK   3    14  4.4075 -  4.3000    0.91     5463   134  0.4466 0.4411        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : NULL                                          
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 1.120            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 55.750           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.009          60886                                  
REMARK   3   ANGLE     :  1.542          82328                                  
REMARK   3   CHIRALITY :  0.068           9336                                  
REMARK   3   PLANARITY :  0.011          10524                                  
REMARK   3   DIHEDRAL  : 14.868          37258                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 74                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 10 THROUGH 144)                   
REMARK   3    ORIGIN FOR THE GROUP (A):  39.0522 -30.5557  88.0704              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.0213 T22:   2.1286                                     
REMARK   3      T33:   1.3029 T12:   0.8059                                     
REMARK   3      T13:  -0.4009 T23:  -0.6683                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6182 L22:   0.2659                                     
REMARK   3      L33:   0.3206 L12:  -0.2092                                     
REMARK   3      L13:   0.3796 L23:  -0.1376                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1841 S12:  -0.8431 S13:  -0.5397                       
REMARK   3      S21:   1.1482 S22:   0.5762 S23:  -0.0335                       
REMARK   3      S31:   0.5243 S32:  -0.0831 S33:   0.1665                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 145 THROUGH 236)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  55.5157 -13.8908  99.6993              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.8937 T22:   3.6237                                     
REMARK   3      T33:   0.7496 T12:   1.1563                                     
REMARK   3      T13:   0.5539 T23:  -1.3805                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0973 L22:   0.0463                                     
REMARK   3      L33:   0.1204 L12:  -0.0661                                     
REMARK   3      L13:  -0.1110 L23:   0.0636                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1299 S12:  -0.1555 S13:   0.1683                       
REMARK   3      S21:   0.1241 S22:   0.1290 S23:   0.1446                       
REMARK   3      S31:   0.1578 S32:   0.3468 S33:   0.1361                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 237 THROUGH 379)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  79.7448 -13.7805  88.2267              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.4516 T22:   3.1020                                     
REMARK   3      T33:   1.6750 T12:   0.6980                                     
REMARK   3      T13:  -0.1767 T23:  -0.3451                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2189 L22:   0.1601                                     
REMARK   3      L33:   0.2904 L12:  -0.1099                                     
REMARK   3      L13:   0.0042 L23:   0.1918                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0857 S12:  -0.9782 S13:   0.7312                       
REMARK   3      S21:   0.5790 S22:  -0.0831 S23:  -0.8395                       
REMARK   3      S31:   1.3429 S32:  -0.3460 S33:   0.0004                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 380 THROUGH 471)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  82.2607 -10.5758  64.6066              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.4453 T22:   2.3025                                     
REMARK   3      T33:   2.3480 T12:   0.6522                                     
REMARK   3      T13:  -0.6748 T23:  -0.1327                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0780 L22:   0.0486                                     
REMARK   3      L33:   0.0401 L12:  -0.0716                                     
REMARK   3      L13:   0.0842 L23:  -0.0726                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4432 S12:  -0.8084 S13:  -0.2967                       
REMARK   3      S21:   0.3320 S22:   0.1017 S23:  -1.0906                       
REMARK   3      S31:   0.3227 S32:  -0.4255 S33:  -0.0005                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 472 THROUGH 542)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  68.7100  -7.9233  47.8809              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2852 T22:   0.6917                                     
REMARK   3      T33:   1.0809 T12:   0.3899                                     
REMARK   3      T13:   0.5314 T23:   0.1826                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8740 L22:   0.7074                                     
REMARK   3      L33:   3.1195 L12:   0.0420                                     
REMARK   3      L13:  -0.0642 L23:   0.6442                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.0263 S12:   0.2321 S13:  -0.0243                       
REMARK   3      S21:   0.0923 S22:   0.0427 S23:   0.3462                       
REMARK   3      S31:   1.1901 S32:  -0.7267 S33:  -1.8340                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 543 THROUGH 630)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  70.2270  -7.7390  33.4802              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7276 T22:   0.0567                                     
REMARK   3      T33:   0.8533 T12:  -0.4314                                     
REMARK   3      T13:  -0.2726 T23:   0.3863                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3307 L22:   0.2741                                     
REMARK   3      L33:   0.4225 L12:   0.0321                                     
REMARK   3      L13:   0.0850 L23:  -0.4058                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2779 S12:   0.7832 S13:  -0.4249                       
REMARK   3      S21:  -0.7115 S22:   0.3614 S23:   0.6246                       
REMARK   3      S31:   0.8064 S32:  -0.7527 S33:   0.1914                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 631 THROUGH 722)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  64.9794  10.3590  34.0397              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4674 T22:   2.0707                                     
REMARK   3      T33:   2.4366 T12:   0.3607                                     
REMARK   3      T13:   0.2777 T23:   0.7673                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1937 L22:  -0.0102                                     
REMARK   3      L33:   0.1020 L12:  -0.0649                                     
REMARK   3      L13:  -0.1689 L23:   0.0667                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0362 S12:   0.5042 S13:   0.3042                       
REMARK   3      S21:   0.4236 S22:  -0.3428 S23:   0.3406                       
REMARK   3      S31:  -0.4922 S32:   0.1871 S33:   0.0002                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 723 THROUGH 878)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  44.2615   7.2171  30.1705              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4858 T22:   3.9521                                     
REMARK   3      T33:   0.9681 T12:   1.2441                                     
REMARK   3      T13:   1.0196 T23:  -0.3994                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4658 L22:   0.3123                                     
REMARK   3      L33:   0.3443 L12:  -0.0047                                     
REMARK   3      L13:  -0.0194 L23:   0.0539                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.5151 S12:  -0.0682 S13:   0.2089                       
REMARK   3      S21:   0.6203 S22:   0.4340 S23:   0.2650                       
REMARK   3      S31:   0.7814 S32:  -0.7858 S33:   0.7608                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 879 THROUGH 904)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  24.2336 -19.6740   7.6635              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.3198 T22:   4.1617                                     
REMARK   3      T33:   3.1419 T12:   0.3939                                     
REMARK   3      T13:  -0.5798 T23:  -0.7459                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2092 L22:   0.0398                                     
REMARK   3      L33:   0.2727 L12:  -0.0870                                     
REMARK   3      L13:  -0.2503 L23:   0.1403                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.7480 S12:   0.0826 S13:   0.3087                       
REMARK   3      S21:  -0.2194 S22:   0.5562 S23:   0.0924                       
REMARK   3      S31:   0.3277 S32:  -0.3576 S33:   0.0103                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 905 THROUGH 1045)                 
REMARK   3    ORIGIN FOR THE GROUP (A):  43.0167 -20.1238   7.9470              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2705 T22:   2.6428                                     
REMARK   3      T33:   1.4371 T12:  -0.5507                                     
REMARK   3      T13:   0.3053 T23:   1.0695                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2061 L22:   0.2456                                     
REMARK   3      L33:   0.1190 L12:  -0.3008                                     
REMARK   3      L13:  -0.3005 L23:   0.1464                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2156 S12:  -1.8020 S13:  -0.3048                       
REMARK   3      S21:   0.6789 S22:   0.9616 S23:  -0.2693                       
REMARK   3      S31:   0.4463 S32:   0.7204 S33:   0.1211                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 1046 THROUGH 1180)                
REMARK   3    ORIGIN FOR THE GROUP (A):  66.9900  -7.4949  -3.9255              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -1.2366 T22:   2.6592                                     
REMARK   3      T33:   0.0071 T12:  -0.9493                                     
REMARK   3      T13:   2.1277 T23:   1.2546                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3750 L22:   0.5790                                     
REMARK   3      L33:   0.3355 L12:  -0.3610                                     
REMARK   3      L13:  -0.2807 L23:   0.4232                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0192 S12:   0.0554 S13:  -0.3618                       
REMARK   3      S21:  -0.1273 S22:   0.2035 S23:  -0.7348                       
REMARK   3      S31:  -0.3664 S32:   0.0645 S33:   0.0689                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 1213 THROUGH 1308)                
REMARK   3    ORIGIN FOR THE GROUP (A):  82.6046  16.0866  -2.6040              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.1595 T22:   2.1957                                     
REMARK   3      T33:   2.5096 T12:   0.4189                                     
REMARK   3      T13:  -0.0192 T23:   0.4360                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1926 L22:   0.0267                                     
REMARK   3      L33:   0.1838 L12:   0.1326                                     
REMARK   3      L13:  -0.2022 L23:  -0.0937                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.9011 S12:   0.4694 S13:   0.5804                       
REMARK   3      S21:   0.6682 S22:  -0.0083 S23:  -1.4966                       
REMARK   3      S31:  -0.7466 S32:   0.3030 S33:   0.0001                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 1323 THROUGH 1420)                
REMARK   3    ORIGIN FOR THE GROUP (A):  88.7074  17.2333  13.3704              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.9592 T22:   2.0279                                     
REMARK   3      T33:   3.2703 T12:  -0.2427                                     
REMARK   3      T13:  -0.2033 T23:   0.5342                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0209 L22:   0.0323                                     
REMARK   3      L33:   0.0595 L12:  -0.0923                                     
REMARK   3      L13:   0.0159 L23:  -0.0993                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.0659 S12:  -0.3831 S13:  -0.0733                       
REMARK   3      S21:   0.2997 S22:  -0.5270 S23:  -0.9962                       
REMARK   3      S31:   0.7551 S32:   0.6952 S33:  -0.0013                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 1421 THROUGH 1526)                
REMARK   3    ORIGIN FOR THE GROUP (A):  96.9016  17.2069  37.3366              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.8533 T22:   1.5566                                     
REMARK   3      T33:   2.5660 T12:   0.0613                                     
REMARK   3      T13:  -0.2983 T23:  -0.4417                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0814 L22:   0.1465                                     
REMARK   3      L33:   0.1409 L12:   0.0642                                     
REMARK   3      L13:   0.1683 L23:   0.0564                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3382 S12:  -1.7727 S13:   0.6051                       
REMARK   3      S21:   0.4749 S22:   1.0076 S23:   0.0046                       
REMARK   3      S31:   0.5467 S32:   0.3521 S33:   0.0009                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 1548 THROUGH 1763)                
REMARK   3    ORIGIN FOR THE GROUP (A): 103.4733 -13.2837  51.2569              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.8607 T22:  -0.0785                                     
REMARK   3      T33:   0.2446 T12:   1.4988                                     
REMARK   3      T13:  -1.0285 T23:   0.6743                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7283 L22:   0.8461                                     
REMARK   3      L33:   0.7682 L12:  -0.8530                                     
REMARK   3      L13:   0.5101 L23:   0.3816                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2545 S12:  -0.6649 S13:  -0.3760                       
REMARK   3      S21:   1.4751 S22:   1.1229 S23:   0.2415                       
REMARK   3      S31:   0.9988 S32:  -0.7287 S33:   0.9871                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 1787 THROUGH 1822)                
REMARK   3    ORIGIN FOR THE GROUP (A):  87.4149 -17.6282  42.3351              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.9148 T22:   1.8249                                     
REMARK   3      T33:   1.8315 T12:   0.9567                                     
REMARK   3      T13:   0.2530 T23:   0.6233                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0028 L22:   0.1516                                     
REMARK   3      L33:   0.1335 L12:   0.0155                                     
REMARK   3      L13:  -0.0086 L23:  -0.1220                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0646 S12:   0.1432 S13:   0.0961                       
REMARK   3      S21:  -0.1025 S22:  -0.1802 S23:   0.4397                       
REMARK   3      S31:   0.1314 S32:   0.0109 S33:   0.0812                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 1856 THROUGH 1975)                
REMARK   3    ORIGIN FOR THE GROUP (A):  95.9667 -44.8920  51.3078              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7116 T22:   0.1186                                     
REMARK   3      T33:   1.0522 T12:   0.1529                                     
REMARK   3      T13:  -0.1506 T23:  -0.4422                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0845 L22:   0.2804                                     
REMARK   3      L33:  -0.0500 L12:  -0.2101                                     
REMARK   3      L13:  -0.0764 L23:   0.3052                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4815 S12:   0.0114 S13:   0.3535                       
REMARK   3      S21:   0.0986 S22:  -0.1952 S23:  -0.5929                       
REMARK   3      S31:   0.6323 S32:   0.6395 S33:  -0.7379                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 1976 THROUGH 2310)                
REMARK   3    ORIGIN FOR THE GROUP (A):  65.7711 -66.7094  54.8756              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7815 T22:   1.5813                                     
REMARK   3      T33:   1.8022 T12:   0.3063                                     
REMARK   3      T13:   0.1268 T23:  -0.2813                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3780 L22:   0.3421                                     
REMARK   3      L33:   0.9256 L12:   0.3935                                     
REMARK   3      L13:   0.0074 L23:  -0.4084                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6648 S12:  -0.7144 S13:  -0.0623                       
REMARK   3      S21:   0.3271 S22:  -0.0120 S23:  -0.1333                       
REMARK   3      S31:   0.2542 S32:   0.2559 S33:   0.0004                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 2311 THROUGH 2514)                
REMARK   3    ORIGIN FOR THE GROUP (A):  16.1063 -44.0757  58.1714              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.3458 T22:   2.1280                                     
REMARK   3      T33:  -0.3918 T12:   0.2975                                     
REMARK   3      T13:   1.6828 T23:   0.6765                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1944 L22:   0.1648                                     
REMARK   3      L33:   0.3009 L12:   0.2686                                     
REMARK   3      L13:   0.1493 L23:  -0.0841                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0860 S12:  -0.0757 S13:   0.8849                       
REMARK   3      S21:  -0.8573 S22:  -0.6100 S23:   0.5897                       
REMARK   3      S31:  -0.6689 S32:  -1.1821 S33:  -3.1190                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 2515 THROUGH 2576)                
REMARK   3    ORIGIN FOR THE GROUP (A):  17.1989 -32.3659  25.5646              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1630 T22:   3.0997                                     
REMARK   3      T33:   2.8442 T12:  -1.5404                                     
REMARK   3      T13:   0.0892 T23:   1.5197                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0396 L22:   0.2729                                     
REMARK   3      L33:   0.2205 L12:  -0.1157                                     
REMARK   3      L13:   0.0792 L23:  -0.0209                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1722 S12:   0.4713 S13:   0.0343                       
REMARK   3      S21:  -0.3894 S22:   0.0983 S23:   0.7621                       
REMARK   3      S31:   0.1869 S32:  -0.2335 S33:   0.0143                       
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 2602 THROUGH 2665)                
REMARK   3    ORIGIN FOR THE GROUP (A):  41.2758 -35.2943  29.0494              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.9599 T22:   3.8952                                     
REMARK   3      T33:   2.7927 T12:  -0.1703                                     
REMARK   3      T13:  -1.3435 T23:  -0.9747                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0568 L22:   0.0954                                     
REMARK   3      L33:   0.0547 L12:  -0.0261                                     
REMARK   3      L13:   0.0710 L23:  -0.0148                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1264 S12:  -0.6855 S13:   0.1394                       
REMARK   3      S21:   0.0511 S22:   0.5194 S23:  -0.8089                       
REMARK   3      S31:   0.3881 S32:   0.2296 S33:   0.0022                       
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 2774 THROUGH 2802)                
REMARK   3    ORIGIN FOR THE GROUP (A):  35.9002 -33.5348  13.2183              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1573 T22:   3.2554                                     
REMARK   3      T33:   2.6255 T12:  -0.1859                                     
REMARK   3      T13:   0.5836 T23:   0.7905                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0429 L22:   0.0795                                     
REMARK   3      L33:   0.0288 L12:   0.0628                                     
REMARK   3      L13:   0.0101 L23:   0.1091                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.7423 S12:   0.2985 S13:  -0.6022                       
REMARK   3      S21:  -0.3613 S22:   0.4649 S23:  -0.6542                       
REMARK   3      S31:   0.4554 S32:   0.5938 S33:   0.0014                       
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 2803 THROUGH 2943)                
REMARK   3    ORIGIN FOR THE GROUP (A):   7.2579  -8.5245  19.4489              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4684 T22:   3.8496                                     
REMARK   3      T33:   2.7469 T12:  -0.3284                                     
REMARK   3      T13:   0.9174 T23:   1.5581                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.6980 L22:   0.0268                                     
REMARK   3      L33:   0.9973 L12:  -0.3045                                     
REMARK   3      L13:   0.5498 L23:  -0.1374                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.0191 S12:  -0.0254 S13:   1.5072                       
REMARK   3      S21:  -0.3008 S22:   0.3261 S23:  -0.4281                       
REMARK   3      S31:  -0.8872 S32:  -1.2784 S33:  -0.3067                       
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 2944 THROUGH 3006)                
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.1950  19.3837  26.5569              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   3.1831 T22:   4.4507                                     
REMARK   3      T33:   2.5090 T12:   0.6493                                     
REMARK   3      T13:   0.0452 T23:   1.1781                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0961 L22:   0.0673                                     
REMARK   3      L33:   0.0973 L12:  -0.1121                                     
REMARK   3      L13:   0.0243 L23:  -0.0232                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4877 S12:  -0.0209 S13:   0.2559                       
REMARK   3      S21:  -0.3300 S22:  -0.6584 S23:   1.1646                       
REMARK   3      S31:   0.1687 S32:   0.1154 S33:  -0.0001                       
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3008 THROUGH 3095)                
REMARK   3    ORIGIN FOR THE GROUP (A):   9.0056  11.4864  46.2455              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1091 T22:   2.7094                                     
REMARK   3      T33:   1.1829 T12:   0.0687                                     
REMARK   3      T13:   0.2765 T23:   0.8667                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0410 L22:   0.2941                                     
REMARK   3      L33:   0.1389 L12:   0.0235                                     
REMARK   3      L13:   0.0449 L23:   0.1568                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2622 S12:  -0.6535 S13:  -0.1847                       
REMARK   3      S21:   0.0951 S22:  -0.6707 S23:  -0.5372                       
REMARK   3      S31:  -0.3522 S32:   0.7837 S33:  -0.8223                       
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3096 THROUGH 3199)                
REMARK   3    ORIGIN FOR THE GROUP (A):  28.8576  16.4727  43.1770              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.6345 T22:   2.6606                                     
REMARK   3      T33:   2.6169 T12:   0.8869                                     
REMARK   3      T13:  -0.7569 T23:  -0.6397                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0908 L22:   0.3100                                     
REMARK   3      L33:   0.1497 L12:  -0.0541                                     
REMARK   3      L13:  -0.0528 L23:   0.3208                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1691 S12:  -1.1067 S13:   0.1671                       
REMARK   3      S21:   0.6591 S22:  -0.5523 S23:   0.3456                       
REMARK   3      S31:   0.0016 S32:  -0.0257 S33:  -0.0052                       
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3227 THROUGH 3314)                
REMARK   3    ORIGIN FOR THE GROUP (A):  20.9778  40.4893  33.4782              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   3.6719 T22:   2.4283                                     
REMARK   3      T33:   2.6964 T12:   1.2284                                     
REMARK   3      T13:  -0.8215 T23:  -0.4257                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0360 L22:   0.1366                                     
REMARK   3      L33:   0.0700 L12:  -0.0877                                     
REMARK   3      L13:  -0.0363 L23:   0.0966                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.7082 S12:  -0.2036 S13:   0.6217                       
REMARK   3      S21:  -0.1408 S22:  -0.3085 S23:  -0.0655                       
REMARK   3      S31:  -0.7462 S32:   0.8150 S33:  -0.0000                       
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3315 THROUGH 3405)                
REMARK   3    ORIGIN FOR THE GROUP (A):  19.3561  53.4881  19.0601              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0609 T22:   1.9895                                     
REMARK   3      T33:   1.2609 T12:   0.8904                                     
REMARK   3      T13:   0.5903 T23:  -1.2710                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3952 L22:   0.3401                                     
REMARK   3      L33:   0.3593 L12:   0.3719                                     
REMARK   3      L13:  -0.3534 L23:  -0.2581                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3223 S12:   0.3550 S13:   0.9593                       
REMARK   3      S21:   0.1417 S22:   0.3828 S23:  -0.2874                       
REMARK   3      S31:  -0.8807 S32:  -0.7085 S33:   0.3993                       
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3406 THROUGH 3576)                
REMARK   3    ORIGIN FOR THE GROUP (A):  41.8078  40.7979  -1.4242              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.9503 T22:   2.4128                                     
REMARK   3      T33:   2.5856 T12:   0.4650                                     
REMARK   3      T13:  -0.2807 T23:  -0.4763                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0293 L22:   0.1218                                     
REMARK   3      L33:   0.1623 L12:  -0.1121                                     
REMARK   3      L13:   0.0467 L23:  -0.0538                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1535 S12:  -0.2717 S13:   0.7627                       
REMARK   3      S21:   0.7027 S22:  -0.1167 S23:  -0.2141                       
REMARK   3      S31:  -1.3288 S32:   1.0975 S33:  -0.0076                       
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3577 THROUGH 3680)                
REMARK   3    ORIGIN FOR THE GROUP (A):  41.0761  17.1044 -31.9316              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.3965 T22:   2.6588                                     
REMARK   3      T33:   1.6044 T12:  -0.3982                                     
REMARK   3      T13:   0.2566 T23:  -0.1089                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0751 L22:   0.1370                                     
REMARK   3      L33:  -0.0063 L12:  -0.1307                                     
REMARK   3      L13:  -0.1036 L23:   0.0163                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2917 S12:   1.3723 S13:   0.0344                       
REMARK   3      S21:  -0.7066 S22:   0.4489 S23:  -0.0219                       
REMARK   3      S31:   0.3433 S32:  -0.4676 S33:  -0.0002                       
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3681 THROUGH 3755)                
REMARK   3    ORIGIN FOR THE GROUP (A):  48.4626  11.7741  -4.9540              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7436 T22:   1.4818                                     
REMARK   3      T33:   0.4525 T12:   0.3265                                     
REMARK   3      T13:   1.7887 T23:   0.3949                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0017 L22:   0.8630                                     
REMARK   3      L33:   0.7613 L12:  -0.0618                                     
REMARK   3      L13:   0.0957 L23:  -0.1770                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1916 S12:  -1.2873 S13:  -0.2398                       
REMARK   3      S21:   0.1504 S22:  -0.2338 S23:  -0.8428                       
REMARK   3      S31:  -0.3005 S32:   0.2501 S33:  -0.8250                       
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3756 THROUGH 3808)                
REMARK   3    ORIGIN FOR THE GROUP (A):  32.4026  19.9050   0.8266              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.3044 T22:   2.2852                                     
REMARK   3      T33:   1.2455 T12:   0.2800                                     
REMARK   3      T13:  -0.4531 T23:   0.1456                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0366 L22:   0.3127                                     
REMARK   3      L33:   0.0837 L12:  -0.0859                                     
REMARK   3      L13:   0.0169 L23:   0.0068                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4777 S12:   0.9745 S13:   0.1795                       
REMARK   3      S21:   1.1766 S22:  -0.6247 S23:  -0.1943                       
REMARK   3      S31:   0.1145 S32:   0.8148 S33:  -0.0063                       
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3809 THROUGH 3894)                
REMARK   3    ORIGIN FOR THE GROUP (A):  10.7958   1.6316 -11.1168              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1324 T22:   3.8085                                     
REMARK   3      T33:   0.9939 T12:  -1.4356                                     
REMARK   3      T13:   0.1204 T23:   1.2280                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9397 L22:   1.3632                                     
REMARK   3      L33:   1.9941 L12:   0.6839                                     
REMARK   3      L13:  -0.1335 L23:   0.9652                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5519 S12:   0.8801 S13:   0.1613                       
REMARK   3      S21:  -0.5707 S22:  -0.6369 S23:   0.8658                       
REMARK   3      S31:  -0.6218 S32:  -1.1597 S33:  -1.0826                       
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3895 THROUGH 3972)                
REMARK   3    ORIGIN FOR THE GROUP (A):  19.0279  12.9315  -1.8924              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4973 T22:   2.4354                                     
REMARK   3      T33:   1.9733 T12:   0.3122                                     
REMARK   3      T13:   0.0485 T23:   0.1205                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0672 L22:   0.0304                                     
REMARK   3      L33:   0.1229 L12:   0.1316                                     
REMARK   3      L13:  -0.1498 L23:  -0.1922                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6620 S12:   0.2746 S13:   0.4953                       
REMARK   3      S21:   0.1019 S22:  -0.8815 S23:  -0.7345                       
REMARK   3      S31:   0.5297 S32:   0.5912 S33:  -0.0094                       
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    SELECTION: (CHAIN 'A' AND RESID 3973 THROUGH 4128)                
REMARK   3    ORIGIN FOR THE GROUP (A):  13.7202  25.2047  -6.0894              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7816 T22:   2.8136                                     
REMARK   3      T33:   2.3529 T12:   0.5163                                     
REMARK   3      T13:  -0.2901 T23:  -0.1031                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2277 L22:   0.4075                                     
REMARK   3      L33:   0.2653 L12:   0.2074                                     
REMARK   3      L13:   0.2561 L23:   0.3541                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2937 S12:  -0.8052 S13:  -0.0249                       
REMARK   3      S21:  -1.3277 S22:  -0.2901 S23:  -0.3811                       
REMARK   3      S31:   0.9663 S32:   0.4202 S33:  -0.0013                       
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 10 THROUGH 144)                   
REMARK   3    ORIGIN FOR THE GROUP (A): -43.1758  95.0508 142.9455              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.0585 T22:   3.9208                                     
REMARK   3      T33:   1.2528 T12:  -0.2729                                     
REMARK   3      T13:  -0.0725 T23:   0.2137                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3194 L22:   0.2977                                     
REMARK   3      L33:   0.3697 L12:   0.0298                                     
REMARK   3      L13:   0.2419 L23:  -0.1038                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4316 S12:  -0.5671 S13:   0.6950                       
REMARK   3      S21:   0.3268 S22:  -0.2192 S23:   0.3469                       
REMARK   3      S31:  -0.7510 S32:  -0.4591 S33:  -0.4582                       
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 145 THROUGH 236)                  
REMARK   3    ORIGIN FOR THE GROUP (A): -59.3173  72.8740 144.6662              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7865 T22:   2.3110                                     
REMARK   3      T33:   0.7941 T12:   0.7951                                     
REMARK   3      T13:   0.9575 T23:   0.3558                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1407 L22:   0.3545                                     
REMARK   3      L33:   0.3535 L12:  -0.0222                                     
REMARK   3      L13:   0.0787 L23:   0.1086                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1834 S12:   0.0584 S13:   0.1132                       
REMARK   3      S21:   0.9231 S22:   0.0237 S23:   0.3401                       
REMARK   3      S31:   0.1238 S32:   0.4732 S33:   0.3606                       
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 237 THROUGH 379)                  
REMARK   3    ORIGIN FOR THE GROUP (A): -67.2449  60.2319 122.7989              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.1187 T22:   2.9839                                     
REMARK   3      T33:   2.0060 T12:   0.5766                                     
REMARK   3      T13:   0.6477 T23:   0.0385                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0633 L22:   0.1461                                     
REMARK   3      L33:   0.3082 L12:   0.0081                                     
REMARK   3      L13:   0.2521 L23:   0.0723                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.7541 S12:  -0.2096 S13:  -1.0225                       
REMARK   3      S21:  -0.1112 S22:   0.0806 S23:   0.5777                       
REMARK   3      S31:   0.2638 S32:   0.5889 S33:  -0.0002                       
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 380 THROUGH 471)                  
REMARK   3    ORIGIN FOR THE GROUP (A): -51.7790  48.8926 109.2844              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.1236 T22:   2.5306                                     
REMARK   3      T33:   1.8003 T12:   0.4984                                     
REMARK   3      T13:  -0.3470 T23:   0.2836                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1511 L22:   0.1099                                     
REMARK   3      L33:  -0.0648 L12:  -0.1815                                     
REMARK   3      L13:  -0.0074 L23:  -0.0111                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.9265 S12:  -0.9794 S13:   1.1310                       
REMARK   3      S21:  -0.3321 S22:  -0.2760 S23:  -0.2572                       
REMARK   3      S31:   0.0383 S32:  -0.0584 S33:   0.0003                       
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 472 THROUGH 542)                  
REMARK   3    ORIGIN FOR THE GROUP (A): -29.4985  47.4147 110.5107              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9699 T22:   0.0983                                     
REMARK   3      T33:   0.9875 T12:   0.8567                                     
REMARK   3      T13:   1.0316 T23:  -0.3382                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1195 L22:   1.0041                                     
REMARK   3      L33:  -0.0201 L12:  -0.3763                                     
REMARK   3      L13:   0.0107 L23:  -0.1294                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0137 S12:  -0.2171 S13:   0.5696                       
REMARK   3      S21:  -0.2842 S22:  -0.2166 S23:  -1.3249                       
REMARK   3      S31:  -0.5707 S32:   0.2071 S33:  -0.1375                       
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 543 THROUGH 630)                  
REMARK   3    ORIGIN FOR THE GROUP (A): -19.5201  40.9950 102.4836              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1755 T22:   1.4859                                     
REMARK   3      T33:   0.9942 T12:   1.8800                                     
REMARK   3      T13:  -0.5044 T23:   0.3266                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9706 L22:   0.6607                                     
REMARK   3      L33:   0.8488 L12:  -0.5846                                     
REMARK   3      L13:  -0.2693 L23:  -0.0059                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3359 S12:   1.0881 S13:   0.2721                       
REMARK   3      S21:  -0.9775 S22:   0.0063 S23:  -0.5692                       
REMARK   3      S31:  -0.1251 S32:   0.9727 S33:   1.4345                       
REMARK   3   TLS GROUP : 42                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 631 THROUGH 722)                  
REMARK   3    ORIGIN FOR THE GROUP (A): -17.5405  28.7422 115.5422              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.8092 T22:   1.7893                                     
REMARK   3      T33:   1.5548 T12:   0.8184                                     
REMARK   3      T13:   0.4346 T23:  -0.4725                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7899 L22:   0.3390                                     
REMARK   3      L33:   0.6395 L12:  -0.1537                                     
REMARK   3      L13:   0.6065 L23:  -0.3226                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.5644 S12:  -0.9588 S13:  -1.1388                       
REMARK   3      S21:   0.4723 S22:  -0.1015 S23:   0.5158                       
REMARK   3      S31:   0.2170 S32:  -1.2871 S33:   0.0948                       
REMARK   3   TLS GROUP : 43                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 723 THROUGH 878)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  -1.3250  38.7116 126.4733              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5238 T22:   2.3616                                     
REMARK   3      T33:  -0.1950 T12:   0.0196                                     
REMARK   3      T13:   0.0898 T23:   0.3131                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0477 L22:   0.1618                                     
REMARK   3      L33:   0.6186 L12:  -0.1669                                     
REMARK   3      L13:   0.0630 L23:  -0.2013                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3560 S12:   0.4226 S13:   0.2166                       
REMARK   3      S21:  -0.0493 S22:  -0.4897 S23:  -0.4595                       
REMARK   3      S31:  -1.5329 S32:   0.1170 S33:  -0.1177                       
REMARK   3   TLS GROUP : 44                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 879 THROUGH 904)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  29.3686  61.3869 113.6436              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.9682 T22:   3.2165                                     
REMARK   3      T33:   1.8299 T12:   1.0479                                     
REMARK   3      T13:   0.3215 T23:  -1.3109                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5729 L22:   0.6175                                     
REMARK   3      L33:   0.1473 L12:   0.1847                                     
REMARK   3      L13:  -0.2653 L23:  -0.2249                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.7267 S12:   0.0837 S13:   0.5063                       
REMARK   3      S21:   0.2920 S22:   0.3072 S23:   0.3249                       
REMARK   3      S31:   0.6738 S32:   0.6442 S33:   0.3425                       
REMARK   3   TLS GROUP : 45                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 905 THROUGH 1045)                 
REMARK   3    ORIGIN FOR THE GROUP (A):  17.5945  54.4377 100.6163              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.5223 T22:   1.4159                                     
REMARK   3      T33:   1.8445 T12:   0.0958                                     
REMARK   3      T13:   0.0424 T23:   0.2823                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0028 L22:   0.3052                                     
REMARK   3      L33:   0.1241 L12:  -0.1432                                     
REMARK   3      L13:  -0.0315 L23:   0.0928                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.2453 S12:  -0.7184 S13:  -1.5814                       
REMARK   3      S21:  -0.7030 S22:  -0.1494 S23:   0.4735                       
REMARK   3      S31:   0.0685 S32:   1.4982 S33:  -0.0136                       
REMARK   3   TLS GROUP : 46                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 1046 THROUGH 1180)                
REMARK   3    ORIGIN FOR THE GROUP (A):  12.0699  29.4316  85.4433              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.4730 T22:   1.9135                                     
REMARK   3      T33:   1.5024 T12:   1.2004                                     
REMARK   3      T13:  -0.1817 T23:  -1.1267                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2343 L22:   0.5640                                     
REMARK   3      L33:   0.0853 L12:   0.2931                                     
REMARK   3      L13:  -0.0924 L23:  -0.0600                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3465 S12:   1.1978 S13:   1.2694                       
REMARK   3      S21:  -1.3204 S22:   0.2771 S23:   1.1762                       
REMARK   3      S31:   1.0677 S32:   0.5483 S33:   0.1121                       
REMARK   3   TLS GROUP : 47                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 1213 THROUGH 1308)                
REMARK   3    ORIGIN FOR THE GROUP (A):   0.8586   3.8726  88.6073              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.8191 T22:   0.2134                                     
REMARK   3      T33:   2.8582 T12:   1.9916                                     
REMARK   3      T13:  -0.6373 T23:  -0.7337                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6475 L22:   0.4931                                     
REMARK   3      L33:   0.2967 L12:  -0.0316                                     
REMARK   3      L13:  -0.3914 L23:  -0.0789                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.7008 S12:   0.6201 S13:  -1.0217                       
REMARK   3      S21:   0.3245 S22:   0.2140 S23:   0.4977                       
REMARK   3      S31:   0.3815 S32:  -0.3421 S33:   0.1093                       
REMARK   3   TLS GROUP : 48                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 1323 THROUGH 1420)                
REMARK   3    ORIGIN FOR THE GROUP (A): -15.8257   5.8422  92.1669              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.9271 T22:  -0.2420                                     
REMARK   3      T33:   2.6734 T12:   0.0681                                     
REMARK   3      T13:  -0.7950 T23:  -0.9291                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2633 L22:   0.4070                                     
REMARK   3      L33:   0.4275 L12:   0.2565                                     
REMARK   3      L13:  -0.2088 L23:  -0.3926                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3078 S12:  -0.0571 S13:   0.5801                       
REMARK   3      S21:  -1.0126 S22:   0.8229 S23:  -0.3414                       
REMARK   3      S31:  -0.2270 S32:  -0.1928 S33:   0.9087                       
REMARK   3   TLS GROUP : 49                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 1421 THROUGH 1526)                
REMARK   3    ORIGIN FOR THE GROUP (A): -39.6368  10.8132 100.4130              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.7335 T22:   1.5294                                     
REMARK   3      T33:   2.7765 T12:  -0.1120                                     
REMARK   3      T13:   0.0491 T23:  -0.1679                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1005 L22:   0.0880                                     
REMARK   3      L33:  -0.0307 L12:  -0.0025                                     
REMARK   3      L13:   0.0094 L23:   0.0059                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3417 S12:   0.0011 S13:  -0.3885                       
REMARK   3      S21:   1.0838 S22:   0.0160 S23:   0.3387                       
REMARK   3      S31:   0.4652 S32:  -1.6488 S33:   0.0001                       
REMARK   3   TLS GROUP : 50                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 1548 THROUGH 1763)                
REMARK   3    ORIGIN FOR THE GROUP (A): -55.0570  38.4259  87.1932              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.0827 T22:  -0.8440                                     
REMARK   3      T33:   0.9816 T12:   1.1904                                     
REMARK   3      T13:  -0.4775 T23:   0.3676                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3709 L22:   1.0493                                     
REMARK   3      L33:   0.6009 L12:  -0.3379                                     
REMARK   3      L13:   0.4191 L23:  -0.4771                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0671 S12:  -0.1802 S13:   0.4432                       
REMARK   3      S21:   1.3323 S22:   0.8235 S23:   0.2617                       
REMARK   3      S31:   0.5948 S32:  -0.6608 S33:  -0.1739                       
REMARK   3   TLS GROUP : 51                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 1787 THROUGH 1822)                
REMARK   3    ORIGIN FOR THE GROUP (A): -37.0024  45.5208  91.3717              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.5122 T22:   1.7997                                     
REMARK   3      T33:   2.6096 T12:   0.0031                                     
REMARK   3      T13:   0.8232 T23:   0.4802                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1690 L22:   0.0237                                     
REMARK   3      L33:  -0.0010 L12:   0.0307                                     
REMARK   3      L13:  -0.0031 L23:  -0.0211                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2057 S12:  -0.1107 S13:   0.6208                       
REMARK   3      S21:   0.4753 S22:   0.2944 S23:  -0.1936                       
REMARK   3      S31:  -0.7798 S32:   0.1468 S33:  -0.0033                       
REMARK   3   TLS GROUP : 52                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 1856 THROUGH 1975)                
REMARK   3    ORIGIN FOR THE GROUP (A): -50.0829  68.0434  75.1221              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.1871 T22:  -0.3866                                     
REMARK   3      T33:   0.3663 T12:   0.4556                                     
REMARK   3      T13:   0.2164 T23:  -0.1225                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6409 L22:   0.0581                                     
REMARK   3      L33:   1.8859 L12:  -0.2139                                     
REMARK   3      L13:   0.2943 L23:   0.1531                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0189 S12:  -0.3560 S13:  -0.1974                       
REMARK   3      S21:   0.4379 S22:   0.7385 S23:  -0.1975                       
REMARK   3      S31:   1.1086 S32:   0.3429 S33:   1.4878                       
REMARK   3   TLS GROUP : 53                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 1976 THROUGH 2310)                
REMARK   3    ORIGIN FOR THE GROUP (A): -33.9488 100.5678  83.6180              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.1901 T22:   1.5587                                     
REMARK   3      T33:   1.1921 T12:   0.2743                                     
REMARK   3      T13:  -0.4017 T23:  -0.2365                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2923 L22:   0.0324                                     
REMARK   3      L33:   0.4956 L12:  -1.0572                                     
REMARK   3      L13:   0.5454 L23:   1.1238                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5602 S12:  -0.9094 S13:   0.1126                       
REMARK   3      S21:   0.8548 S22:   0.2280 S23:  -0.7234                       
REMARK   3      S31:   0.2791 S32:  -0.3157 S33:  -0.0166                       
REMARK   3   TLS GROUP : 54                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 2311 THROUGH 2514)                
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.3080 104.2741 130.0672              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.5949 T22:   0.9082                                     
REMARK   3      T33:   1.1503 T12:   0.6487                                     
REMARK   3      T13:  -0.6583 T23:  -0.6971                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3721 L22:   0.7533                                     
REMARK   3      L33:   0.3500 L12:  -0.0110                                     
REMARK   3      L13:  -0.3357 L23:   0.0267                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1069 S12:  -1.0415 S13:   0.6763                       
REMARK   3      S21:   0.1547 S22:  -0.3289 S23:  -0.2664                       
REMARK   3      S31:  -0.9647 S32:   0.2144 S33:  -1.6025                       
REMARK   3   TLS GROUP : 55                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 2515 THROUGH 2576)                
REMARK   3    ORIGIN FOR THE GROUP (A):  19.3444  81.8951 119.0534              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.6140 T22:   0.3148                                     
REMARK   3      T33:   2.6768 T12:   0.5991                                     
REMARK   3      T13:   0.8770 T23:   0.3436                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7148 L22:   0.1389                                     
REMARK   3      L33:   0.5876 L12:  -0.2768                                     
REMARK   3      L13:   0.1535 L23:   0.1115                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6558 S12:  -0.5707 S13:   0.2139                       
REMARK   3      S21:  -0.4904 S22:  -0.6523 S23:   0.0261                       
REMARK   3      S31:   0.3305 S32:   0.4167 S33:  -0.2001                       
REMARK   3   TLS GROUP : 56                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 2602 THROUGH 2665)                
REMARK   3    ORIGIN FOR THE GROUP (A):   3.1602  74.9780 102.1332              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.7109 T22:   3.0215                                     
REMARK   3      T33:   3.0614 T12:   0.7951                                     
REMARK   3      T13:   0.5886 T23:  -0.7825                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0791 L22:   0.0923                                     
REMARK   3      L33:   0.1309 L12:   0.0139                                     
REMARK   3      L13:   0.1268 L23:  -0.0465                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4631 S12:   1.3297 S13:   0.1946                       
REMARK   3      S21:   0.2349 S22:  -0.8640 S23:   0.5168                       
REMARK   3      S31:  -0.0013 S32:   0.3616 S33:   0.0004                       
REMARK   3   TLS GROUP : 57                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 2774 THROUGH 2802)                
REMARK   3    ORIGIN FOR THE GROUP (A):  18.0138  68.8924 101.0362              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   3.2945 T22:   2.0988                                     
REMARK   3      T33:   2.6529 T12:   0.6583                                     
REMARK   3      T13:  -0.2734 T23:   0.2913                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0251 L22:   0.0877                                     
REMARK   3      L33:   0.0304 L12:  -0.0087                                     
REMARK   3      L13:  -0.0103 L23:  -0.0649                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1523 S12:   0.3878 S13:  -0.2474                       
REMARK   3      S21:  -0.0281 S22:  -0.4272 S23:   0.7197                       
REMARK   3      S31:   0.1949 S32:  -0.0339 S33:  -0.0005                       
REMARK   3   TLS GROUP : 58                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 2803 THROUGH 2943)                
REMARK   3    ORIGIN FOR THE GROUP (A):  29.9953  65.2140 136.4934              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.7535 T22:   1.7091                                     
REMARK   3      T33:   1.3906 T12:   0.2732                                     
REMARK   3      T13:   0.0370 T23:   0.0445                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0836 L22:   0.4567                                     
REMARK   3      L33:   0.2495 L12:  -0.0382                                     
REMARK   3      L13:  -0.2395 L23:   0.2551                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4100 S12:  -0.6448 S13:  -0.3422                       
REMARK   3      S21:   0.5970 S22:   1.0381 S23:  -0.9241                       
REMARK   3      S31:   0.8207 S32:   1.0364 S33:   0.0003                       
REMARK   3   TLS GROUP : 59                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 2944 THROUGH 3006)                
REMARK   3    ORIGIN FOR THE GROUP (A):  29.1420  49.1863 161.6777              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   3.3877 T22:   2.8875                                     
REMARK   3      T33:   1.5132 T12:   0.2002                                     
REMARK   3      T13:  -0.1605 T23:  -0.1873                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4379 L22:   0.1071                                     
REMARK   3      L33:   0.1152 L12:  -0.2139                                     
REMARK   3      L13:   0.2186 L23:  -0.0949                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.1431 S12:   0.2573 S13:   0.9198                       
REMARK   3      S21:   0.3165 S22:  -1.0728 S23:   0.0540                       
REMARK   3      S31:  -0.4637 S32:   0.5892 S33:  -0.0220                       
REMARK   3   TLS GROUP : 60                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3008 THROUGH 3095)                
REMARK   3    ORIGIN FOR THE GROUP (A):   6.3252  57.3117 160.8644              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.7912 T22:   2.3650                                     
REMARK   3      T33:   0.8951 T12:   0.9477                                     
REMARK   3      T13:  -0.7873 T23:  -0.6696                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0872 L22:   0.1260                                     
REMARK   3      L33:   0.3499 L12:  -0.0674                                     
REMARK   3      L13:   0.0380 L23:   0.0162                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0979 S12:  -0.0325 S13:   0.2798                       
REMARK   3      S21:   0.0197 S22:  -0.3540 S23:   0.4021                       
REMARK   3      S31:  -1.1447 S32:   0.1387 S33:   0.6629                       
REMARK   3   TLS GROUP : 61                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3096 THROUGH 3199)                
REMARK   3    ORIGIN FOR THE GROUP (A):  -2.3298  41.7006 148.2615              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.8985 T22:   1.9631                                     
REMARK   3      T33:   2.2526 T12:  -0.5024                                     
REMARK   3      T13:  -0.5480 T23:   0.2725                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1169 L22:   0.2175                                     
REMARK   3      L33:   0.0530 L12:  -0.0935                                     
REMARK   3      L13:  -0.0291 L23:  -0.0938                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.1465 S12:  -0.3220 S13:   1.0634                       
REMARK   3      S21:  -0.1725 S22:  -0.8134 S23:  -0.0284                       
REMARK   3      S31:   1.5307 S32:  -0.6391 S33:   0.0000                       
REMARK   3   TLS GROUP : 62                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3227 THROUGH 3314)                
REMARK   3    ORIGIN FOR THE GROUP (A):  10.1825  22.8316 162.2882              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.0615 T22:   1.9014                                     
REMARK   3      T33:   2.7621 T12:   0.0679                                     
REMARK   3      T13:  -0.2703 T23:   0.4664                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1036 L22:  -0.1325                                     
REMARK   3      L33:   0.2174 L12:  -0.0364                                     
REMARK   3      L13:  -0.1414 L23:  -0.1723                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4127 S12:  -0.2073 S13:   0.4426                       
REMARK   3      S21:   1.8887 S22:   0.0970 S23:  -0.8212                       
REMARK   3      S31:   0.0661 S32:  -1.3224 S33:   0.0001                       
REMARK   3   TLS GROUP : 63                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3315 THROUGH 3405)                
REMARK   3    ORIGIN FOR THE GROUP (A):  23.7716   7.1961 162.3982              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5465 T22:   1.8545                                     
REMARK   3      T33:   2.4207 T12:   0.0002                                     
REMARK   3      T13:  -0.4331 T23:   1.0630                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1413 L22:   0.4686                                     
REMARK   3      L33:   0.1760 L12:   0.2051                                     
REMARK   3      L13:   0.0390 L23:   0.2158                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1981 S12:  -0.6620 S13:  -0.5940                       
REMARK   3      S21:   0.7759 S22:   0.1878 S23:  -0.2262                       
REMARK   3      S31:   0.2777 S32:   0.4382 S33:   0.0998                       
REMARK   3   TLS GROUP : 64                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3406 THROUGH 3576)                
REMARK   3    ORIGIN FOR THE GROUP (A):  26.0270   2.8246 130.2669              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.1647 T22:   2.6519                                     
REMARK   3      T33:   3.1540 T12:   0.0576                                     
REMARK   3      T13:   0.1255 T23:  -0.4867                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3391 L22:   0.2007                                     
REMARK   3      L33:   0.1066 L12:  -0.1296                                     
REMARK   3      L13:  -0.1256 L23:   0.0395                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4134 S12:   0.7308 S13:  -0.1464                       
REMARK   3      S21:   0.1738 S22:  -1.2834 S23:   0.0855                       
REMARK   3      S31:   0.0646 S32:  -0.0753 S33:  -0.0004                       
REMARK   3   TLS GROUP : 65                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3577 THROUGH 3680)                
REMARK   3    ORIGIN FOR THE GROUP (A):  50.8467  14.8161 102.3319              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.9050 T22:   3.1916                                     
REMARK   3      T33:   2.9408 T12:  -0.0975                                     
REMARK   3      T13:   0.5382 T23:  -1.1549                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2741 L22:   0.1793                                     
REMARK   3      L33:   0.0866 L12:  -0.0011                                     
REMARK   3      L13:  -0.0386 L23:   0.0354                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0539 S12:   1.7583 S13:  -0.0854                       
REMARK   3      S21:  -0.8188 S22:   0.1716 S23:   0.2523                       
REMARK   3      S31:   0.1438 S32:  -0.5795 S33:   0.0002                       
REMARK   3   TLS GROUP : 66                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3681 THROUGH 3755)                
REMARK   3    ORIGIN FOR THE GROUP (A):  24.4364  21.7757 108.3255              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.7856 T22:   2.5327                                     
REMARK   3      T33:   1.2144 T12:   0.6834                                     
REMARK   3      T13:   0.4936 T23:   0.0587                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4139 L22:   0.6740                                     
REMARK   3      L33:   0.3505 L12:  -0.5271                                     
REMARK   3      L13:   0.3172 L23:  -0.4965                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5251 S12:   0.6526 S13:   0.2104                       
REMARK   3      S21:   1.3441 S22:  -0.1932 S23:  -0.8908                       
REMARK   3      S31:   0.5317 S32:   0.1054 S33:  -0.1571                       
REMARK   3   TLS GROUP : 67                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3756 THROUGH 3808)                
REMARK   3    ORIGIN FOR THE GROUP (A):  29.6286  24.7898 126.3898              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1650 T22:   1.9647                                     
REMARK   3      T33:   2.1859 T12:  -0.5928                                     
REMARK   3      T13:  -0.4926 T23:   0.2567                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0787 L22:  -0.0720                                     
REMARK   3      L33:   0.0247 L12:  -0.0557                                     
REMARK   3      L13:   0.0700 L23:   0.0034                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0426 S12:   0.5409 S13:  -1.1703                       
REMARK   3      S21:   0.1345 S22:   0.3229 S23:   0.0517                       
REMARK   3      S31:   0.9068 S32:   0.0995 S33:  -0.0001                       
REMARK   3   TLS GROUP : 68                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3809 THROUGH 3894)                
REMARK   3    ORIGIN FOR THE GROUP (A):  52.0529  45.2224 124.3387              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7674 T22:   2.0613                                     
REMARK   3      T33:   2.5533 T12:   0.0803                                     
REMARK   3      T13:  -0.4590 T23:  -0.3422                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1671 L22:  -0.0046                                     
REMARK   3      L33:   0.2842 L12:   0.0733                                     
REMARK   3      L13:  -0.0609 L23:  -0.0676                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1603 S12:  -0.1844 S13:  -0.1062                       
REMARK   3      S21:   1.1281 S22:   0.0558 S23:  -0.2540                       
REMARK   3      S31:  -0.5226 S32:  -0.2072 S33:   0.0001                       
REMARK   3   TLS GROUP : 69                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3895 THROUGH 3972)                
REMARK   3    ORIGIN FOR THE GROUP (A):  39.5269  35.3043 130.0278              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2644 T22:   1.6963                                     
REMARK   3      T33:   1.3711 T12:   0.1314                                     
REMARK   3      T13:   0.7608 T23:   0.0601                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0217 L22:   0.1493                                     
REMARK   3      L33:   0.0021 L12:  -0.0760                                     
REMARK   3      L13:   0.0084 L23:   0.0996                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.7203 S12:   0.4482 S13:  -0.5432                       
REMARK   3      S21:  -1.1031 S22:   0.0260 S23:  -0.1578                       
REMARK   3      S31:   0.4753 S32:   1.3052 S33:  -0.0011                       
REMARK   3   TLS GROUP : 70                                                     
REMARK   3    SELECTION: (CHAIN 'B' AND RESID 3973 THROUGH 4128)                
REMARK   3    ORIGIN FOR THE GROUP (A):  46.2869  26.3899 138.2406              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.9194 T22:   2.8156                                     
REMARK   3      T33:   2.6709 T12:   0.4566                                     
REMARK   3      T13:  -1.0954 T23:   0.0749                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4136 L22:   0.0782                                     
REMARK   3      L33:   0.4535 L12:   0.1918                                     
REMARK   3      L13:  -0.2201 L23:  -0.2859                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.2945 S12:   1.0477 S13:   1.2409                       
REMARK   3      S21:  -0.0380 S22:   0.1967 S23:  -0.3011                       
REMARK   3      S31:  -0.3917 S32:   0.7273 S33:  -0.0027                       
REMARK   3   TLS GROUP : 71                                                     
REMARK   3    SELECTION: (CHAIN 'K' AND RESID 101 THROUGH 133)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  46.5468 -56.8974  49.7977              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   4.8023 T22:   3.8987                                     
REMARK   3      T33:   3.4193 T12:   0.3817                                     
REMARK   3      T13:  -1.2551 T23:   0.5063                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0278 L22:   0.0298                                     
REMARK   3      L33:   0.0009 L12:  -0.0168                                     
REMARK   3      L13:  -0.0384 L23:   0.0128                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1456 S12:   0.4620 S13:  -0.2207                       
REMARK   3      S21:   0.0151 S22:   0.1514 S23:   0.0695                       
REMARK   3      S31:   0.3184 S32:   0.2749 S33:  -0.0002                       
REMARK   3   TLS GROUP : 72                                                     
REMARK   3    SELECTION: (CHAIN 'K' AND RESID 201 THROUGH 221)                  
REMARK   3    ORIGIN FOR THE GROUP (A):  89.2903 -81.0468  44.2304              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.0564 T22:   2.9576                                     
REMARK   3      T33:   2.8007 T12:   0.2020                                     
REMARK   3      T13:   0.5673 T23:   0.2462                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0200 L22:   0.0125                                     
REMARK   3      L33:   0.0166 L12:  -0.0009                                     
REMARK   3      L13:  -0.0153 L23:  -0.0133                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0682 S12:  -0.2894 S13:   0.0020                       
REMARK   3      S21:   0.0962 S22:   0.0883 S23:   0.0977                       
REMARK   3      S31:  -0.0266 S32:   0.0223 S33:  -0.0001                       
REMARK   3   TLS GROUP : 73                                                     
REMARK   3    SELECTION: (CHAIN 'S' AND RESID 101 THROUGH 133)                  
REMARK   3    ORIGIN FOR THE GROUP (A): -19.2682  97.9106 101.5621              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   2.2622 T22:   2.8472                                     
REMARK   3      T33:   3.4317 T12:   0.1168                                     
REMARK   3      T13:   1.3026 T23:   0.3167                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0173 L22:   0.0018                                     
REMARK   3      L33:   0.0128 L12:   0.0267                                     
REMARK   3      L13:  -0.0010 L23:  -0.0010                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3055 S12:   0.1901 S13:   0.0105                       
REMARK   3      S21:  -0.7557 S22:  -0.6386 S23:  -0.3083                       
REMARK   3      S31:  -0.2040 S32:   0.1358 S33:   0.0020                       
REMARK   3   TLS GROUP : 74                                                     
REMARK   3    SELECTION: (CHAIN 'S' AND RESID 201 THROUGH 221)                  
REMARK   3    ORIGIN FOR THE GROUP (A): -39.7248  99.4018  55.9924              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1203 T22:   1.5366                                     
REMARK   3      T33:   1.6912 T12:  -0.0725                                     
REMARK   3      T13:  -0.1335 T23:  -0.4353                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0262 L22:   0.0292                                     
REMARK   3      L33:   0.0142 L12:   0.0338                                     
REMARK   3      L13:   0.0094 L23:   0.0041                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0079 S12:  -0.1336 S13:  -0.2180                       
REMARK   3      S21:   0.3585 S22:  -0.2813 S23:  -0.2734                       
REMARK   3      S31:  -0.2366 S32:  -0.2769 S33:   0.0003                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 5LUQ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 09-SEP-16.                  
REMARK 100 THE DEPOSITION ID IS D_1200001358.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 23-MAY-12; 25-JUN-11               
REMARK 200  TEMPERATURE           (KELVIN) : 100; 100                           
REMARK 200  PH                             : 6.2-6.7; 6.2-6.7                   
REMARK 200  NUMBER OF CRYSTALS USED        : 2                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y; Y                               
REMARK 200  RADIATION SOURCE               : ESRF; ESRF                         
REMARK 200  BEAMLINE                       : ID29; ID23-1                       
REMARK 200  X-RAY GENERATOR MODEL          : NULL; NULL                         
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M; M                               
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9791; 0.9791                     
REMARK 200  MONOCHROMATOR                  : NULL; NULL                         
REMARK 200  OPTICS                         : NULL; NULL                         
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL; PIXEL                       
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M-F; DECTRIS      
REMARK 200                                   PILATUS 6M-F                       
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XSCALE                             
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 84530                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 4.300                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 49.920                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.9                               
REMARK 200  DATA REDUNDANCY                : 35.20                              
REMARK 200  R MERGE                    (I) : 0.16000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 15.4000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 4.30                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 4.41                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.9                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 13.10                              
REMARK 200  R MERGE FOR SHELL          (I) : 0.93600                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.400                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH; SINGLE WAVELENGTH           
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: SAD                          
REMARK 200 SOFTWARE USED: PHENIX                                                
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 62.00                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.27                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M BIS-TRIS, 200 MM NACL, 30%         
REMARK 280  GLYCEROL, 10 MM EDTA, 18% PEG 8000, VAPOR DIFFUSION, HANGING        
REMARK 280  DROP, TEMPERATURE 293K. 0.1 M BIS-TRIS, 200 MM NACL, 30%            
REMARK 280  GLYCEROL, 10 MM EDTA, 8% PEG 8000, VAPOR DIFFUSION, HANGING DROP,   
REMARK 280  TEMPERATURE 293K                                                    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y+1/2,-Z                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       66.32000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 2460 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 177500 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -16.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, K                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 2820 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 176280 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -17.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, S                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MSE A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     GLY A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     GLY A     5                                                      
REMARK 465     ALA A     6                                                      
REMARK 465     GLY A     7                                                      
REMARK 465     VAL A     8                                                      
REMARK 465     ARG A     9                                                      
REMARK 465     PRO A   498                                                      
REMARK 465     LYS A   499                                                      
REMARK 465     GLY A   500                                                      
REMARK 465     PRO A   501                                                      
REMARK 465     GLU A   502                                                      
REMARK 465     GLY A   517                                                      
REMARK 465     LYS A   518                                                      
REMARK 465     TRP A   519                                                      
REMARK 465     LYS A   520                                                      
REMARK 465     VAL A   521                                                      
REMARK 465     PRO A   522                                                      
REMARK 465     THR A   523                                                      
REMARK 465     TYR A   524                                                      
REMARK 465     PHE A   683                                                      
REMARK 465     GLU A   684                                                      
REMARK 465     GLY A   685                                                      
REMARK 465     VAL A   686                                                      
REMARK 465     SER A   687                                                      
REMARK 465     PRO A   688                                                      
REMARK 465     LYS A   689                                                      
REMARK 465     SER A   690                                                      
REMARK 465     LEU A   691                                                      
REMARK 465     LYS A   692                                                      
REMARK 465     HIS A   693                                                      
REMARK 465     SER A   694                                                      
REMARK 465     PRO A   695                                                      
REMARK 465     GLU A   696                                                      
REMARK 465     ASP A   697                                                      
REMARK 465     PRO A   698                                                      
REMARK 465     GLU A   699                                                      
REMARK 465     LYS A   810                                                      
REMARK 465     ASN A   811                                                      
REMARK 465     ASN A   812                                                      
REMARK 465     TRP A   813                                                      
REMARK 465     GLU A   814                                                      
REMARK 465     VAL A   815                                                      
REMARK 465     SER A   816                                                      
REMARK 465     ALA A   817                                                      
REMARK 465     LEU A   818                                                      
REMARK 465     SER A   819                                                      
REMARK 465     ARG A   820                                                      
REMARK 465     ALA A   821                                                      
REMARK 465     ALA A   822                                                      
REMARK 465     GLN A   823                                                      
REMARK 465     LYS A   824                                                      
REMARK 465     GLY A   825                                                      
REMARK 465     PHE A   826                                                      
REMARK 465     ASN A   827                                                      
REMARK 465     LYS A   828                                                      
REMARK 465     VAL A   829                                                      
REMARK 465     VAL A   830                                                      
REMARK 465     LEU A   831                                                      
REMARK 465     LYS A   832                                                      
REMARK 465     HIS A   833                                                      
REMARK 465     LEU A   834                                                      
REMARK 465     LYS A   835                                                      
REMARK 465     LYS A   836                                                      
REMARK 465     THR A   837                                                      
REMARK 465     LYS A   838                                                      
REMARK 465     ASN A   839                                                      
REMARK 465     LEU A   840                                                      
REMARK 465     SER A   841                                                      
REMARK 465     SER A   842                                                      
REMARK 465     ASN A   843                                                      
REMARK 465     GLU A   844                                                      
REMARK 465     ALA A   845                                                      
REMARK 465     THR A  1181                                                      
REMARK 465     GLU A  1182                                                      
REMARK 465     CYS A  1183                                                      
REMARK 465     ARG A  1184                                                      
REMARK 465     HIS A  1185                                                      
REMARK 465     LYS A  1186                                                      
REMARK 465     SER A  1187                                                      
REMARK 465     ILE A  1188                                                      
REMARK 465     GLU A  1189                                                      
REMARK 465     LEU A  1190                                                      
REMARK 465     PHE A  1191                                                      
REMARK 465     TYR A  1192                                                      
REMARK 465     LYS A  1193                                                      
REMARK 465     PHE A  1194                                                      
REMARK 465     VAL A  1195                                                      
REMARK 465     PRO A  1196                                                      
REMARK 465     LEU A  1197                                                      
REMARK 465     LEU A  1198                                                      
REMARK 465     PRO A  1199                                                      
REMARK 465     GLY A  1200                                                      
REMARK 465     ASN A  1201                                                      
REMARK 465     ARG A  1202                                                      
REMARK 465     SER A  1203                                                      
REMARK 465     PRO A  1204                                                      
REMARK 465     ASN A  1205                                                      
REMARK 465     LEU A  1206                                                      
REMARK 465     TRP A  1207                                                      
REMARK 465     LEU A  1208                                                      
REMARK 465     LYS A  1209                                                      
REMARK 465     ASP A  1210                                                      
REMARK 465     VAL A  1211                                                      
REMARK 465     LEU A  1212                                                      
REMARK 465     ALA A  1309                                                      
REMARK 465     GLU A  1310                                                      
REMARK 465     LYS A  1311                                                      
REMARK 465     CYS A  1312                                                      
REMARK 465     PHE A  1313                                                      
REMARK 465     GLY A  1314                                                      
REMARK 465     THR A  1315                                                      
REMARK 465     GLY A  1316                                                      
REMARK 465     ALA A  1317                                                      
REMARK 465     ALA A  1318                                                      
REMARK 465     GLY A  1319                                                      
REMARK 465     ASN A  1320                                                      
REMARK 465     ARG A  1321                                                      
REMARK 465     THR A  1322                                                      
REMARK 465     ARG A  1527                                                      
REMARK 465     LEU A  1528                                                      
REMARK 465     VAL A  1529                                                      
REMARK 465     SER A  1530                                                      
REMARK 465     LEU A  1531                                                      
REMARK 465     LEU A  1532                                                      
REMARK 465     LEU A  1533                                                      
REMARK 465     ASN A  1534                                                      
REMARK 465     PRO A  1535                                                      
REMARK 465     ALA A  1536                                                      
REMARK 465     VAL A  1537                                                      
REMARK 465     LEU A  1538                                                      
REMARK 465     SER A  1539                                                      
REMARK 465     THR A  1540                                                      
REMARK 465     ALA A  1541                                                      
REMARK 465     SER A  1542                                                      
REMARK 465     LEU A  1543                                                      
REMARK 465     GLY A  1544                                                      
REMARK 465     SER A  1545                                                      
REMARK 465     SER A  1546                                                      
REMARK 465     GLN A  1547                                                      
REMARK 465     ASN A  1610                                                      
REMARK 465     GLN A  1611                                                      
REMARK 465     LYS A  1612                                                      
REMARK 465     HIS A  1613                                                      
REMARK 465     GLN A  1614                                                      
REMARK 465     GLY A  1615                                                      
REMARK 465     LEU A  1616                                                      
REMARK 465     LYS A  1617                                                      
REMARK 465     LEU A  1618                                                      
REMARK 465     ALA A  1619                                                      
REMARK 465     THR A  1620                                                      
REMARK 465     THR A  1621                                                      
REMARK 465     ILE A  1622                                                      
REMARK 465     LEU A  1623                                                      
REMARK 465     GLN A  1624                                                      
REMARK 465     HIS A  1625                                                      
REMARK 465     TRP A  1626                                                      
REMARK 465     LYS A  1627                                                      
REMARK 465     LYS A  1628                                                      
REMARK 465     CYS A  1629                                                      
REMARK 465     VAL A  1659                                                      
REMARK 465     SER A  1660                                                      
REMARK 465     PHE A  1661                                                      
REMARK 465     ASN A  1662                                                      
REMARK 465     THR A  1663                                                      
REMARK 465     SER A  1664                                                      
REMARK 465     HIS A  1665                                                      
REMARK 465     GLY A  1666                                                      
REMARK 465     SER A  1667                                                      
REMARK 465     PHE A  1668                                                      
REMARK 465     PRO A  1669                                                      
REMARK 465     GLU A  1670                                                      
REMARK 465     GLU A  1764                                                      
REMARK 465     VAL A  1765                                                      
REMARK 465     LEU A  1766                                                      
REMARK 465     CYS A  1767                                                      
REMARK 465     ARG A  1768                                                      
REMARK 465     GLU A  1769                                                      
REMARK 465     GLN A  1770                                                      
REMARK 465     GLN A  1771                                                      
REMARK 465     HIS A  1772                                                      
REMARK 465     VAL A  1773                                                      
REMARK 465     MSE A  1774                                                      
REMARK 465     GLU A  1775                                                      
REMARK 465     GLU A  1776                                                      
REMARK 465     LEU A  1777                                                      
REMARK 465     PHE A  1778                                                      
REMARK 465     GLN A  1779                                                      
REMARK 465     SER A  1780                                                      
REMARK 465     SER A  1781                                                      
REMARK 465     PHE A  1782                                                      
REMARK 465     ARG A  1783                                                      
REMARK 465     ARG A  1784                                                      
REMARK 465     ILE A  1785                                                      
REMARK 465     ALA A  1786                                                      
REMARK 465     SER A  1823                                                      
REMARK 465     LEU A  1824                                                      
REMARK 465     LEU A  1825                                                      
REMARK 465     THR A  1826                                                      
REMARK 465     LEU A  1827                                                      
REMARK 465     LEU A  1828                                                      
REMARK 465     TRP A  1829                                                      
REMARK 465     HIS A  1830                                                      
REMARK 465     CYS A  1831                                                      
REMARK 465     SER A  1832                                                      
REMARK 465     LEU A  1833                                                      
REMARK 465     ASP A  1834                                                      
REMARK 465     ALA A  1835                                                      
REMARK 465     LEU A  1836                                                      
REMARK 465     ARG A  1837                                                      
REMARK 465     GLU A  1838                                                      
REMARK 465     PHE A  1839                                                      
REMARK 465     PHE A  1840                                                      
REMARK 465     SER A  1841                                                      
REMARK 465     THR A  1842                                                      
REMARK 465     ILE A  1843                                                      
REMARK 465     VAL A  1844                                                      
REMARK 465     VAL A  1845                                                      
REMARK 465     ASP A  1846                                                      
REMARK 465     ALA A  1847                                                      
REMARK 465     ILE A  1848                                                      
REMARK 465     ASP A  1849                                                      
REMARK 465     VAL A  1850                                                      
REMARK 465     LEU A  1851                                                      
REMARK 465     LYS A  1852                                                      
REMARK 465     SER A  1853                                                      
REMARK 465     ARG A  1854                                                      
REMARK 465     PHE A  1855                                                      
REMARK 465     UNK A  2576A                                                     
REMARK 465     UNK A  2576B                                                     
REMARK 465     UNK A  2576C                                                     
REMARK 465     UNK A  2576D                                                     
REMARK 465     UNK A  2576E                                                     
REMARK 465     UNK A  2576F                                                     
REMARK 465     UNK A  2576G                                                     
REMARK 465     UNK A  2576H                                                     
REMARK 465     UNK A  2576I                                                     
REMARK 465     UNK A  2576J                                                     
REMARK 465     UNK A  2576K                                                     
REMARK 465     UNK A  2576L                                                     
REMARK 465     UNK A  2576M                                                     
REMARK 465     UNK A  2576N                                                     
REMARK 465     UNK A  2576O                                                     
REMARK 465     UNK A  2576P                                                     
REMARK 465     UNK A  2576Q                                                     
REMARK 465     UNK A  2576R                                                     
REMARK 465     UNK A  2576S                                                     
REMARK 465     UNK A  2576T                                                     
REMARK 465     UNK A  2576U                                                     
REMARK 465     UNK A  2576V                                                     
REMARK 465     UNK A  2576W                                                     
REMARK 465     UNK A  2576X                                                     
REMARK 465     UNK A  2576Y                                                     
REMARK 465     UNK A  2576Z                                                     
REMARK 465     UNK A  2577A                                                     
REMARK 465     UNK A  2577B                                                     
REMARK 465     MSE A  2577C                                                     
REMARK 465     UNK A  2577D                                                     
REMARK 465     UNK A  2577E                                                     
REMARK 465     UNK A  2577F                                                     
REMARK 465     UNK A  2577G                                                     
REMARK 465     UNK A  2577H                                                     
REMARK 465     UNK A  2577I                                                     
REMARK 465     UNK A  2577J                                                     
REMARK 465     UNK A  2577K                                                     
REMARK 465     UNK A  2577L                                                     
REMARK 465     UNK A  2577M                                                     
REMARK 465     UNK A  2577N                                                     
REMARK 465     UNK A  2577O                                                     
REMARK 465     UNK A  2577P                                                     
REMARK 465     UNK A  2577Q                                                     
REMARK 465     UNK A  2577R                                                     
REMARK 465     UNK A  2577S                                                     
REMARK 465     UNK A  2577T                                                     
REMARK 465     UNK A  2577U                                                     
REMARK 465     UNK A  2577V                                                     
REMARK 465     UNK A  2577W                                                     
REMARK 465     UNK A  2577X                                                     
REMARK 465     UNK A  2577Y                                                     
REMARK 465     UNK A  2577Z                                                     
REMARK 465     UNK A  2578A                                                     
REMARK 465     UNK A  2578B                                                     
REMARK 465     UNK A  2578C                                                     
REMARK 465     UNK A  2578D                                                     
REMARK 465     UNK A  2578E                                                     
REMARK 465     UNK A  2578F                                                     
REMARK 465     UNK A  2578G                                                     
REMARK 465     UNK A  2578H                                                     
REMARK 465     UNK A  2578I                                                     
REMARK 465     UNK A  2578J                                                     
REMARK 465     UNK A  2578K                                                     
REMARK 465     UNK A  2578L                                                     
REMARK 465     UNK A  2578M                                                     
REMARK 465     UNK A  2578N                                                     
REMARK 465     UNK A  2578O                                                     
REMARK 465     UNK A  2578P                                                     
REMARK 465     UNK A  2578Q                                                     
REMARK 465     UNK A  2578R                                                     
REMARK 465     UNK A  2578S                                                     
REMARK 465     UNK A  2578T                                                     
REMARK 465     UNK A  2578U                                                     
REMARK 465     UNK A  2578V                                                     
REMARK 465     UNK A  2578W                                                     
REMARK 465     UNK A  2578X                                                     
REMARK 465     UNK A  2578Y                                                     
REMARK 465     UNK A  2578Z                                                     
REMARK 465     UNK A  2579A                                                     
REMARK 465     UNK A  2579B                                                     
REMARK 465     UNK A  2579C                                                     
REMARK 465     UNK A  2579D                                                     
REMARK 465     UNK A  2579E                                                     
REMARK 465     UNK A  2579F                                                     
REMARK 465     UNK A  2579G                                                     
REMARK 465     UNK A  2579H                                                     
REMARK 465     UNK A  2579I                                                     
REMARK 465     UNK A  2579J                                                     
REMARK 465     UNK A  2579K                                                     
REMARK 465     UNK A  2579L                                                     
REMARK 465     UNK A  2579M                                                     
REMARK 465     UNK A  2579N                                                     
REMARK 465     MSE A  2733                                                      
REMARK 465     UNK A  2734                                                      
REMARK 465     UNK A  2735                                                      
REMARK 465     UNK A  2736                                                      
REMARK 465     UNK A  2737                                                      
REMARK 465     UNK A  2738                                                      
REMARK 465     UNK A  2739                                                      
REMARK 465     UNK A  2740                                                      
REMARK 465     UNK A  2741                                                      
REMARK 465     MSE A  2742                                                      
REMARK 465     UNK A  2743                                                      
REMARK 465     UNK A  2744                                                      
REMARK 465     UNK A  2745                                                      
REMARK 465     UNK A  2746                                                      
REMARK 465     UNK A  2747                                                      
REMARK 465     UNK A  2748                                                      
REMARK 465     UNK A  2749                                                      
REMARK 465     UNK A  2750                                                      
REMARK 465     UNK A  2751                                                      
REMARK 465     UNK A  2752                                                      
REMARK 465     UNK A  2753                                                      
REMARK 465     UNK A  2754                                                      
REMARK 465     UNK A  2755                                                      
REMARK 465     UNK A  2756                                                      
REMARK 465     UNK A  2757                                                      
REMARK 465     UNK A  2758                                                      
REMARK 465     UNK A  2759                                                      
REMARK 465     UNK A  2760                                                      
REMARK 465     UNK A  2761                                                      
REMARK 465     UNK A  2762                                                      
REMARK 465     MSE A  2763                                                      
REMARK 465     UNK A  2764                                                      
REMARK 465     UNK A  2765                                                      
REMARK 465     UNK A  2766                                                      
REMARK 465     UNK A  2767                                                      
REMARK 465     UNK A  2768                                                      
REMARK 465     UNK A  2769                                                      
REMARK 465     UNK A  2770                                                      
REMARK 465     UNK A  2771                                                      
REMARK 465     UNK A  2772                                                      
REMARK 465     UNK A  2773                                                      
REMARK 465     LEU A  3200                                                      
REMARK 465     PRO A  3201                                                      
REMARK 465     GLU A  3202                                                      
REMARK 465     ASP A  3203                                                      
REMARK 465     ASN A  3204                                                      
REMARK 465     SER A  3205                                                      
REMARK 465     MSE A  3206                                                      
REMARK 465     ASN A  3207                                                      
REMARK 465     VAL A  3208                                                      
REMARK 465     ASP A  3209                                                      
REMARK 465     GLN A  3210                                                      
REMARK 465     ASP A  3211                                                      
REMARK 465     GLY A  3212                                                      
REMARK 465     ASP A  3213                                                      
REMARK 465     PRO A  3214                                                      
REMARK 465     SER A  3215                                                      
REMARK 465     ASP A  3216                                                      
REMARK 465     ARG A  3217                                                      
REMARK 465     MSE A  3218                                                      
REMARK 465     GLU A  3219                                                      
REMARK 465     VAL A  3220                                                      
REMARK 465     GLN A  3221                                                      
REMARK 465     GLU A  3222                                                      
REMARK 465     GLN A  3223                                                      
REMARK 465     GLU A  3224                                                      
REMARK 465     GLU A  3225                                                      
REMARK 465     ASP A  3226                                                      
REMARK 465     LEU A  3360                                                      
REMARK 465     GLU A  3361                                                      
REMARK 465     LEU A  3362                                                      
REMARK 465     SER A  3363                                                      
REMARK 465     GLY A  3364                                                      
REMARK 465     SER A  3365                                                      
REMARK 465     SER A  3366                                                      
REMARK 465     SER A  3367                                                      
REMARK 465     GLU A  3368                                                      
REMARK 465     ASP A  3369                                                      
REMARK 465     SER A  3370                                                      
REMARK 465     GLU A  3371                                                      
REMARK 465     LYS A  3372                                                      
REMARK 465     UNK K   -39                                                      
REMARK 465     UNK K   -38                                                      
REMARK 465     UNK K   -37                                                      
REMARK 465     UNK K   -36                                                      
REMARK 465     UNK K   -35                                                      
REMARK 465     UNK K   -34                                                      
REMARK 465     UNK K   -33                                                      
REMARK 465     UNK K   -32                                                      
REMARK 465     UNK K   -31                                                      
REMARK 465     UNK K   -30                                                      
REMARK 465     UNK K   -29                                                      
REMARK 465     UNK K   -28                                                      
REMARK 465     UNK K   -27                                                      
REMARK 465     UNK K   -26                                                      
REMARK 465     UNK K   -25                                                      
REMARK 465     UNK K   -24                                                      
REMARK 465     UNK K   -23                                                      
REMARK 465     UNK K   -22                                                      
REMARK 465     UNK K   -21                                                      
REMARK 465     UNK K   -20                                                      
REMARK 465     UNK K   -19                                                      
REMARK 465     UNK K   -18                                                      
REMARK 465     UNK K   -17                                                      
REMARK 465     UNK K   -16                                                      
REMARK 465     UNK K   -15                                                      
REMARK 465     UNK K   -14                                                      
REMARK 465     UNK K   -13                                                      
REMARK 465     UNK K   -12                                                      
REMARK 465     UNK K   -11                                                      
REMARK 465     UNK K   -10                                                      
REMARK 465     UNK K    -9                                                      
REMARK 465     UNK K    -8                                                      
REMARK 465     UNK K    -7                                                      
REMARK 465     UNK K    -6                                                      
REMARK 465     UNK K    -5                                                      
REMARK 465     UNK K    -4                                                      
REMARK 465     UNK K    -3                                                      
REMARK 465     UNK K    -2                                                      
REMARK 465     UNK K    -1                                                      
REMARK 465     UNK K     0                                                      
REMARK 465     UNK K     1                                                      
REMARK 465     UNK K     2                                                      
REMARK 465     UNK K     3                                                      
REMARK 465     UNK K     4                                                      
REMARK 465     UNK K     5                                                      
REMARK 465     UNK K     6                                                      
REMARK 465     UNK K     7                                                      
REMARK 465     UNK K     8                                                      
REMARK 465     UNK K     9                                                      
REMARK 465     UNK K    10                                                      
REMARK 465     UNK K    11                                                      
REMARK 465     UNK K    12                                                      
REMARK 465     UNK K    13                                                      
REMARK 465     UNK K    14                                                      
REMARK 465     UNK K    15                                                      
REMARK 465     UNK K    16                                                      
REMARK 465     UNK K    17                                                      
REMARK 465     UNK K    18                                                      
REMARK 465     UNK K    19                                                      
REMARK 465     UNK K    20                                                      
REMARK 465     UNK K    21                                                      
REMARK 465     UNK K    22                                                      
REMARK 465     UNK K    23                                                      
REMARK 465     UNK K    24                                                      
REMARK 465     UNK K    25                                                      
REMARK 465     UNK K    26                                                      
REMARK 465     UNK K    27                                                      
REMARK 465     UNK K    28                                                      
REMARK 465     UNK K    29                                                      
REMARK 465     UNK K    30                                                      
REMARK 465     UNK K    31                                                      
REMARK 465     UNK K    32                                                      
REMARK 465     UNK K    33                                                      
REMARK 465     UNK K    34                                                      
REMARK 465     UNK K    35                                                      
REMARK 465     UNK K    36                                                      
REMARK 465     UNK K    37                                                      
REMARK 465     UNK K    38                                                      
REMARK 465     UNK K    39                                                      
REMARK 465     UNK K    40                                                      
REMARK 465     UNK K    41                                                      
REMARK 465     UNK K    42                                                      
REMARK 465     UNK K    43                                                      
REMARK 465     UNK K    44                                                      
REMARK 465     UNK K    45                                                      
REMARK 465     UNK K    46                                                      
REMARK 465     UNK K    47                                                      
REMARK 465     UNK K    48                                                      
REMARK 465     UNK K    49                                                      
REMARK 465     UNK K    50                                                      
REMARK 465     UNK K    51                                                      
REMARK 465     UNK K    52                                                      
REMARK 465     UNK K    53                                                      
REMARK 465     UNK K    54                                                      
REMARK 465     UNK K    55                                                      
REMARK 465     UNK K    56                                                      
REMARK 465     UNK K    57                                                      
REMARK 465     UNK K    58                                                      
REMARK 465     UNK K    59                                                      
REMARK 465     UNK K    60                                                      
REMARK 465     UNK K    61                                                      
REMARK 465     UNK K    62                                                      
REMARK 465     UNK K    63                                                      
REMARK 465     UNK K    64                                                      
REMARK 465     UNK K    65                                                      
REMARK 465     UNK K    66                                                      
REMARK 465     UNK K    67                                                      
REMARK 465     UNK K    68                                                      
REMARK 465     UNK K    69                                                      
REMARK 465     UNK K    70                                                      
REMARK 465     UNK K    71                                                      
REMARK 465     UNK K    72                                                      
REMARK 465     UNK K    73                                                      
REMARK 465     UNK K    74                                                      
REMARK 465     UNK K    75                                                      
REMARK 465     UNK K    76                                                      
REMARK 465     UNK K    77                                                      
REMARK 465     UNK K    78                                                      
REMARK 465     UNK K    79                                                      
REMARK 465     UNK K    80                                                      
REMARK 465     UNK K    81                                                      
REMARK 465     UNK K    82                                                      
REMARK 465     UNK K    83                                                      
REMARK 465     UNK K    84                                                      
REMARK 465     UNK K    85                                                      
REMARK 465     UNK K    86                                                      
REMARK 465     UNK K    87                                                      
REMARK 465     UNK K    88                                                      
REMARK 465     UNK K    89                                                      
REMARK 465     UNK K    90                                                      
REMARK 465     UNK K    91                                                      
REMARK 465     UNK K    92                                                      
REMARK 465     UNK K    93                                                      
REMARK 465     UNK K    94                                                      
REMARK 465     UNK K    95                                                      
REMARK 465     UNK K    96                                                      
REMARK 465     UNK K    97                                                      
REMARK 465     UNK K    98                                                      
REMARK 465     UNK K    99                                                      
REMARK 465     UNK K   100                                                      
REMARK 465     MSE B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     GLY B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     GLY B     5                                                      
REMARK 465     ALA B     6                                                      
REMARK 465     GLY B     7                                                      
REMARK 465     VAL B     8                                                      
REMARK 465     ARG B     9                                                      
REMARK 465     PRO B   498                                                      
REMARK 465     LYS B   499                                                      
REMARK 465     GLY B   500                                                      
REMARK 465     PRO B   501                                                      
REMARK 465     GLU B   502                                                      
REMARK 465     GLY B   517                                                      
REMARK 465     LYS B   518                                                      
REMARK 465     TRP B   519                                                      
REMARK 465     LYS B   520                                                      
REMARK 465     VAL B   521                                                      
REMARK 465     PRO B   522                                                      
REMARK 465     THR B   523                                                      
REMARK 465     TYR B   524                                                      
REMARK 465     PHE B   683                                                      
REMARK 465     GLU B   684                                                      
REMARK 465     GLY B   685                                                      
REMARK 465     VAL B   686                                                      
REMARK 465     SER B   687                                                      
REMARK 465     PRO B   688                                                      
REMARK 465     LYS B   689                                                      
REMARK 465     SER B   690                                                      
REMARK 465     LEU B   691                                                      
REMARK 465     LYS B   692                                                      
REMARK 465     HIS B   693                                                      
REMARK 465     SER B   694                                                      
REMARK 465     PRO B   695                                                      
REMARK 465     GLU B   696                                                      
REMARK 465     ASP B   697                                                      
REMARK 465     PRO B   698                                                      
REMARK 465     GLU B   699                                                      
REMARK 465     LYS B   810                                                      
REMARK 465     ASN B   811                                                      
REMARK 465     ASN B   812                                                      
REMARK 465     TRP B   813                                                      
REMARK 465     GLU B   814                                                      
REMARK 465     VAL B   815                                                      
REMARK 465     SER B   816                                                      
REMARK 465     ALA B   817                                                      
REMARK 465     LEU B   818                                                      
REMARK 465     SER B   819                                                      
REMARK 465     ARG B   820                                                      
REMARK 465     ALA B   821                                                      
REMARK 465     ALA B   822                                                      
REMARK 465     GLN B   823                                                      
REMARK 465     LYS B   824                                                      
REMARK 465     GLY B   825                                                      
REMARK 465     PHE B   826                                                      
REMARK 465     ASN B   827                                                      
REMARK 465     LYS B   828                                                      
REMARK 465     VAL B   829                                                      
REMARK 465     VAL B   830                                                      
REMARK 465     LEU B   831                                                      
REMARK 465     LYS B   832                                                      
REMARK 465     HIS B   833                                                      
REMARK 465     LEU B   834                                                      
REMARK 465     LYS B   835                                                      
REMARK 465     LYS B   836                                                      
REMARK 465     THR B   837                                                      
REMARK 465     LYS B   838                                                      
REMARK 465     ASN B   839                                                      
REMARK 465     LEU B   840                                                      
REMARK 465     SER B   841                                                      
REMARK 465     SER B   842                                                      
REMARK 465     ASN B   843                                                      
REMARK 465     GLU B   844                                                      
REMARK 465     ALA B   845                                                      
REMARK 465     THR B  1181                                                      
REMARK 465     GLU B  1182                                                      
REMARK 465     CYS B  1183                                                      
REMARK 465     ARG B  1184                                                      
REMARK 465     HIS B  1185                                                      
REMARK 465     LYS B  1186                                                      
REMARK 465     SER B  1187                                                      
REMARK 465     ILE B  1188                                                      
REMARK 465     GLU B  1189                                                      
REMARK 465     LEU B  1190                                                      
REMARK 465     PHE B  1191                                                      
REMARK 465     TYR B  1192                                                      
REMARK 465     LYS B  1193                                                      
REMARK 465     PHE B  1194                                                      
REMARK 465     VAL B  1195                                                      
REMARK 465     PRO B  1196                                                      
REMARK 465     LEU B  1197                                                      
REMARK 465     LEU B  1198                                                      
REMARK 465     PRO B  1199                                                      
REMARK 465     GLY B  1200                                                      
REMARK 465     ASN B  1201                                                      
REMARK 465     ARG B  1202                                                      
REMARK 465     SER B  1203                                                      
REMARK 465     PRO B  1204                                                      
REMARK 465     ASN B  1205                                                      
REMARK 465     LEU B  1206                                                      
REMARK 465     TRP B  1207                                                      
REMARK 465     LEU B  1208                                                      
REMARK 465     LYS B  1209                                                      
REMARK 465     ASP B  1210                                                      
REMARK 465     VAL B  1211                                                      
REMARK 465     LEU B  1212                                                      
REMARK 465     ALA B  1309                                                      
REMARK 465     GLU B  1310                                                      
REMARK 465     LYS B  1311                                                      
REMARK 465     CYS B  1312                                                      
REMARK 465     PHE B  1313                                                      
REMARK 465     GLY B  1314                                                      
REMARK 465     THR B  1315                                                      
REMARK 465     GLY B  1316                                                      
REMARK 465     ALA B  1317                                                      
REMARK 465     ALA B  1318                                                      
REMARK 465     GLY B  1319                                                      
REMARK 465     ASN B  1320                                                      
REMARK 465     ARG B  1321                                                      
REMARK 465     THR B  1322                                                      
REMARK 465     ARG B  1527                                                      
REMARK 465     LEU B  1528                                                      
REMARK 465     VAL B  1529                                                      
REMARK 465     SER B  1530                                                      
REMARK 465     LEU B  1531                                                      
REMARK 465     LEU B  1532                                                      
REMARK 465     LEU B  1533                                                      
REMARK 465     ASN B  1534                                                      
REMARK 465     PRO B  1535                                                      
REMARK 465     ALA B  1536                                                      
REMARK 465     VAL B  1537                                                      
REMARK 465     LEU B  1538                                                      
REMARK 465     SER B  1539                                                      
REMARK 465     THR B  1540                                                      
REMARK 465     ALA B  1541                                                      
REMARK 465     SER B  1542                                                      
REMARK 465     LEU B  1543                                                      
REMARK 465     GLY B  1544                                                      
REMARK 465     SER B  1545                                                      
REMARK 465     SER B  1546                                                      
REMARK 465     GLN B  1547                                                      
REMARK 465     ASN B  1610                                                      
REMARK 465     GLN B  1611                                                      
REMARK 465     LYS B  1612                                                      
REMARK 465     HIS B  1613                                                      
REMARK 465     GLN B  1614                                                      
REMARK 465     GLY B  1615                                                      
REMARK 465     LEU B  1616                                                      
REMARK 465     LYS B  1617                                                      
REMARK 465     LEU B  1618                                                      
REMARK 465     ALA B  1619                                                      
REMARK 465     THR B  1620                                                      
REMARK 465     THR B  1621                                                      
REMARK 465     ILE B  1622                                                      
REMARK 465     LEU B  1623                                                      
REMARK 465     GLN B  1624                                                      
REMARK 465     HIS B  1625                                                      
REMARK 465     TRP B  1626                                                      
REMARK 465     LYS B  1627                                                      
REMARK 465     LYS B  1628                                                      
REMARK 465     CYS B  1629                                                      
REMARK 465     VAL B  1659                                                      
REMARK 465     SER B  1660                                                      
REMARK 465     PHE B  1661                                                      
REMARK 465     ASN B  1662                                                      
REMARK 465     THR B  1663                                                      
REMARK 465     SER B  1664                                                      
REMARK 465     HIS B  1665                                                      
REMARK 465     GLY B  1666                                                      
REMARK 465     SER B  1667                                                      
REMARK 465     PHE B  1668                                                      
REMARK 465     PRO B  1669                                                      
REMARK 465     GLU B  1670                                                      
REMARK 465     GLU B  1764                                                      
REMARK 465     VAL B  1765                                                      
REMARK 465     LEU B  1766                                                      
REMARK 465     CYS B  1767                                                      
REMARK 465     ARG B  1768                                                      
REMARK 465     GLU B  1769                                                      
REMARK 465     GLN B  1770                                                      
REMARK 465     GLN B  1771                                                      
REMARK 465     HIS B  1772                                                      
REMARK 465     VAL B  1773                                                      
REMARK 465     MSE B  1774                                                      
REMARK 465     GLU B  1775                                                      
REMARK 465     GLU B  1776                                                      
REMARK 465     LEU B  1777                                                      
REMARK 465     PHE B  1778                                                      
REMARK 465     GLN B  1779                                                      
REMARK 465     SER B  1780                                                      
REMARK 465     SER B  1781                                                      
REMARK 465     PHE B  1782                                                      
REMARK 465     ARG B  1783                                                      
REMARK 465     ARG B  1784                                                      
REMARK 465     ILE B  1785                                                      
REMARK 465     ALA B  1786                                                      
REMARK 465     SER B  1823                                                      
REMARK 465     LEU B  1824                                                      
REMARK 465     LEU B  1825                                                      
REMARK 465     THR B  1826                                                      
REMARK 465     LEU B  1827                                                      
REMARK 465     LEU B  1828                                                      
REMARK 465     TRP B  1829                                                      
REMARK 465     HIS B  1830                                                      
REMARK 465     CYS B  1831                                                      
REMARK 465     SER B  1832                                                      
REMARK 465     LEU B  1833                                                      
REMARK 465     ASP B  1834                                                      
REMARK 465     ALA B  1835                                                      
REMARK 465     LEU B  1836                                                      
REMARK 465     ARG B  1837                                                      
REMARK 465     GLU B  1838                                                      
REMARK 465     PHE B  1839                                                      
REMARK 465     PHE B  1840                                                      
REMARK 465     SER B  1841                                                      
REMARK 465     THR B  1842                                                      
REMARK 465     ILE B  1843                                                      
REMARK 465     VAL B  1844                                                      
REMARK 465     VAL B  1845                                                      
REMARK 465     ASP B  1846                                                      
REMARK 465     ALA B  1847                                                      
REMARK 465     ILE B  1848                                                      
REMARK 465     ASP B  1849                                                      
REMARK 465     VAL B  1850                                                      
REMARK 465     LEU B  1851                                                      
REMARK 465     LYS B  1852                                                      
REMARK 465     SER B  1853                                                      
REMARK 465     ARG B  1854                                                      
REMARK 465     PHE B  1855                                                      
REMARK 465     UNK B  2576A                                                     
REMARK 465     UNK B  2576B                                                     
REMARK 465     UNK B  2576C                                                     
REMARK 465     UNK B  2576D                                                     
REMARK 465     UNK B  2576E                                                     
REMARK 465     UNK B  2576F                                                     
REMARK 465     UNK B  2576G                                                     
REMARK 465     UNK B  2576H                                                     
REMARK 465     UNK B  2576I                                                     
REMARK 465     UNK B  2576J                                                     
REMARK 465     UNK B  2576K                                                     
REMARK 465     UNK B  2576L                                                     
REMARK 465     UNK B  2576M                                                     
REMARK 465     UNK B  2576N                                                     
REMARK 465     UNK B  2576O                                                     
REMARK 465     UNK B  2576P                                                     
REMARK 465     UNK B  2576Q                                                     
REMARK 465     UNK B  2576R                                                     
REMARK 465     UNK B  2576S                                                     
REMARK 465     UNK B  2576T                                                     
REMARK 465     UNK B  2576U                                                     
REMARK 465     UNK B  2576V                                                     
REMARK 465     UNK B  2576W                                                     
REMARK 465     UNK B  2576X                                                     
REMARK 465     UNK B  2576Y                                                     
REMARK 465     UNK B  2576Z                                                     
REMARK 465     UNK B  2577A                                                     
REMARK 465     UNK B  2577B                                                     
REMARK 465     MSE B  2577C                                                     
REMARK 465     UNK B  2577D                                                     
REMARK 465     UNK B  2577E                                                     
REMARK 465     UNK B  2577F                                                     
REMARK 465     UNK B  2577G                                                     
REMARK 465     UNK B  2577H                                                     
REMARK 465     UNK B  2577I                                                     
REMARK 465     UNK B  2577J                                                     
REMARK 465     UNK B  2577K                                                     
REMARK 465     UNK B  2577L                                                     
REMARK 465     UNK B  2577M                                                     
REMARK 465     UNK B  2577N                                                     
REMARK 465     UNK B  2577O                                                     
REMARK 465     UNK B  2577P                                                     
REMARK 465     UNK B  2577Q                                                     
REMARK 465     UNK B  2577R                                                     
REMARK 465     UNK B  2577S                                                     
REMARK 465     UNK B  2577T                                                     
REMARK 465     UNK B  2577U                                                     
REMARK 465     UNK B  2577V                                                     
REMARK 465     UNK B  2577W                                                     
REMARK 465     UNK B  2577X                                                     
REMARK 465     UNK B  2577Y                                                     
REMARK 465     UNK B  2577Z                                                     
REMARK 465     UNK B  2578A                                                     
REMARK 465     UNK B  2578B                                                     
REMARK 465     UNK B  2578C                                                     
REMARK 465     UNK B  2578D                                                     
REMARK 465     UNK B  2578E                                                     
REMARK 465     UNK B  2578F                                                     
REMARK 465     UNK B  2578G                                                     
REMARK 465     UNK B  2578H                                                     
REMARK 465     UNK B  2578I                                                     
REMARK 465     UNK B  2578J                                                     
REMARK 465     UNK B  2578K                                                     
REMARK 465     UNK B  2578L                                                     
REMARK 465     UNK B  2578M                                                     
REMARK 465     UNK B  2578N                                                     
REMARK 465     UNK B  2578O                                                     
REMARK 465     UNK B  2578P                                                     
REMARK 465     UNK B  2578Q                                                     
REMARK 465     UNK B  2578R                                                     
REMARK 465     UNK B  2578S                                                     
REMARK 465     UNK B  2578T                                                     
REMARK 465     UNK B  2578U                                                     
REMARK 465     UNK B  2578V                                                     
REMARK 465     UNK B  2578W                                                     
REMARK 465     UNK B  2578X                                                     
REMARK 465     UNK B  2578Y                                                     
REMARK 465     UNK B  2578Z                                                     
REMARK 465     UNK B  2579A                                                     
REMARK 465     UNK B  2579B                                                     
REMARK 465     UNK B  2579C                                                     
REMARK 465     UNK B  2579D                                                     
REMARK 465     UNK B  2579E                                                     
REMARK 465     UNK B  2579F                                                     
REMARK 465     UNK B  2579G                                                     
REMARK 465     UNK B  2579H                                                     
REMARK 465     UNK B  2579I                                                     
REMARK 465     UNK B  2579J                                                     
REMARK 465     UNK B  2579K                                                     
REMARK 465     UNK B  2579L                                                     
REMARK 465     UNK B  2579M                                                     
REMARK 465     UNK B  2579N                                                     
REMARK 465     MSE B  2733                                                      
REMARK 465     UNK B  2734                                                      
REMARK 465     UNK B  2735                                                      
REMARK 465     UNK B  2736                                                      
REMARK 465     UNK B  2737                                                      
REMARK 465     UNK B  2738                                                      
REMARK 465     UNK B  2739                                                      
REMARK 465     UNK B  2740                                                      
REMARK 465     UNK B  2741                                                      
REMARK 465     MSE B  2742                                                      
REMARK 465     UNK B  2743                                                      
REMARK 465     UNK B  2744                                                      
REMARK 465     UNK B  2745                                                      
REMARK 465     UNK B  2746                                                      
REMARK 465     UNK B  2747                                                      
REMARK 465     UNK B  2748                                                      
REMARK 465     UNK B  2749                                                      
REMARK 465     UNK B  2750                                                      
REMARK 465     UNK B  2751                                                      
REMARK 465     UNK B  2752                                                      
REMARK 465     UNK B  2753                                                      
REMARK 465     UNK B  2754                                                      
REMARK 465     UNK B  2755                                                      
REMARK 465     UNK B  2756                                                      
REMARK 465     UNK B  2757                                                      
REMARK 465     UNK B  2758                                                      
REMARK 465     UNK B  2759                                                      
REMARK 465     UNK B  2760                                                      
REMARK 465     UNK B  2761                                                      
REMARK 465     UNK B  2762                                                      
REMARK 465     MSE B  2763                                                      
REMARK 465     UNK B  2764                                                      
REMARK 465     UNK B  2765                                                      
REMARK 465     UNK B  2766                                                      
REMARK 465     UNK B  2767                                                      
REMARK 465     UNK B  2768                                                      
REMARK 465     UNK B  2769                                                      
REMARK 465     UNK B  2770                                                      
REMARK 465     UNK B  2771                                                      
REMARK 465     UNK B  2772                                                      
REMARK 465     UNK B  2773                                                      
REMARK 465     LEU B  3200                                                      
REMARK 465     PRO B  3201                                                      
REMARK 465     GLU B  3202                                                      
REMARK 465     ASP B  3203                                                      
REMARK 465     ASN B  3204                                                      
REMARK 465     SER B  3205                                                      
REMARK 465     MSE B  3206                                                      
REMARK 465     ASN B  3207                                                      
REMARK 465     VAL B  3208                                                      
REMARK 465     ASP B  3209                                                      
REMARK 465     GLN B  3210                                                      
REMARK 465     ASP B  3211                                                      
REMARK 465     GLY B  3212                                                      
REMARK 465     ASP B  3213                                                      
REMARK 465     PRO B  3214                                                      
REMARK 465     SER B  3215                                                      
REMARK 465     ASP B  3216                                                      
REMARK 465     ARG B  3217                                                      
REMARK 465     MSE B  3218                                                      
REMARK 465     GLU B  3219                                                      
REMARK 465     VAL B  3220                                                      
REMARK 465     GLN B  3221                                                      
REMARK 465     GLU B  3222                                                      
REMARK 465     GLN B  3223                                                      
REMARK 465     GLU B  3224                                                      
REMARK 465     GLU B  3225                                                      
REMARK 465     ASP B  3226                                                      
REMARK 465     LEU B  3360                                                      
REMARK 465     GLU B  3361                                                      
REMARK 465     LEU B  3362                                                      
REMARK 465     SER B  3363                                                      
REMARK 465     GLY B  3364                                                      
REMARK 465     SER B  3365                                                      
REMARK 465     SER B  3366                                                      
REMARK 465     SER B  3367                                                      
REMARK 465     GLU B  3368                                                      
REMARK 465     ASP B  3369                                                      
REMARK 465     SER B  3370                                                      
REMARK 465     GLU B  3371                                                      
REMARK 465     LYS B  3372                                                      
REMARK 465     UNK S   -39                                                      
REMARK 465     UNK S   -38                                                      
REMARK 465     UNK S   -37                                                      
REMARK 465     UNK S   -36                                                      
REMARK 465     UNK S   -35                                                      
REMARK 465     UNK S   -34                                                      
REMARK 465     UNK S   -33                                                      
REMARK 465     UNK S   -32                                                      
REMARK 465     UNK S   -31                                                      
REMARK 465     UNK S   -30                                                      
REMARK 465     UNK S   -29                                                      
REMARK 465     UNK S   -28                                                      
REMARK 465     UNK S   -27                                                      
REMARK 465     UNK S   -26                                                      
REMARK 465     UNK S   -25                                                      
REMARK 465     UNK S   -24                                                      
REMARK 465     UNK S   -23                                                      
REMARK 465     UNK S   -22                                                      
REMARK 465     UNK S   -21                                                      
REMARK 465     UNK S   -20                                                      
REMARK 465     UNK S   -19                                                      
REMARK 465     UNK S   -18                                                      
REMARK 465     UNK S   -17                                                      
REMARK 465     UNK S   -16                                                      
REMARK 465     UNK S   -15                                                      
REMARK 465     UNK S   -14                                                      
REMARK 465     UNK S   -13                                                      
REMARK 465     UNK S   -12                                                      
REMARK 465     UNK S   -11                                                      
REMARK 465     UNK S   -10                                                      
REMARK 465     UNK S    -9                                                      
REMARK 465     UNK S    -8                                                      
REMARK 465     UNK S    -7                                                      
REMARK 465     UNK S    -6                                                      
REMARK 465     UNK S    -5                                                      
REMARK 465     UNK S    -4                                                      
REMARK 465     UNK S    -3                                                      
REMARK 465     UNK S    -2                                                      
REMARK 465     UNK S    -1                                                      
REMARK 465     UNK S     0                                                      
REMARK 465     UNK S     1                                                      
REMARK 465     UNK S     2                                                      
REMARK 465     UNK S     3                                                      
REMARK 465     UNK S     4                                                      
REMARK 465     UNK S     5                                                      
REMARK 465     UNK S     6                                                      
REMARK 465     UNK S     7                                                      
REMARK 465     UNK S     8                                                      
REMARK 465     UNK S     9                                                      
REMARK 465     UNK S    10                                                      
REMARK 465     UNK S    11                                                      
REMARK 465     UNK S    12                                                      
REMARK 465     UNK S    13                                                      
REMARK 465     UNK S    14                                                      
REMARK 465     UNK S    15                                                      
REMARK 465     UNK S    16                                                      
REMARK 465     UNK S    17                                                      
REMARK 465     UNK S    18                                                      
REMARK 465     UNK S    19                                                      
REMARK 465     UNK S    20                                                      
REMARK 465     UNK S    21                                                      
REMARK 465     UNK S    22                                                      
REMARK 465     UNK S    23                                                      
REMARK 465     UNK S    24                                                      
REMARK 465     UNK S    25                                                      
REMARK 465     UNK S    26                                                      
REMARK 465     UNK S    27                                                      
REMARK 465     UNK S    28                                                      
REMARK 465     UNK S    29                                                      
REMARK 465     UNK S    30                                                      
REMARK 465     UNK S    31                                                      
REMARK 465     UNK S    32                                                      
REMARK 465     UNK S    33                                                      
REMARK 465     UNK S    34                                                      
REMARK 465     UNK S    35                                                      
REMARK 465     UNK S    36                                                      
REMARK 465     UNK S    37                                                      
REMARK 465     UNK S    38                                                      
REMARK 465     UNK S    39                                                      
REMARK 465     UNK S    40                                                      
REMARK 465     UNK S    41                                                      
REMARK 465     UNK S    42                                                      
REMARK 465     UNK S    43                                                      
REMARK 465     UNK S    44                                                      
REMARK 465     UNK S    45                                                      
REMARK 465     UNK S    46                                                      
REMARK 465     UNK S    47                                                      
REMARK 465     UNK S    48                                                      
REMARK 465     UNK S    49                                                      
REMARK 465     UNK S    50                                                      
REMARK 465     UNK S    51                                                      
REMARK 465     UNK S    52                                                      
REMARK 465     UNK S    53                                                      
REMARK 465     UNK S    54                                                      
REMARK 465     UNK S    55                                                      
REMARK 465     UNK S    56                                                      
REMARK 465     UNK S    57                                                      
REMARK 465     UNK S    58                                                      
REMARK 465     UNK S    59                                                      
REMARK 465     UNK S    60                                                      
REMARK 465     UNK S    61                                                      
REMARK 465     UNK S    62                                                      
REMARK 465     UNK S    63                                                      
REMARK 465     UNK S    64                                                      
REMARK 465     UNK S    65                                                      
REMARK 465     UNK S    66                                                      
REMARK 465     UNK S    67                                                      
REMARK 465     UNK S    68                                                      
REMARK 465     UNK S    69                                                      
REMARK 465     UNK S    70                                                      
REMARK 465     UNK S    71                                                      
REMARK 465     UNK S    72                                                      
REMARK 465     UNK S    73                                                      
REMARK 465     UNK S    74                                                      
REMARK 465     UNK S    75                                                      
REMARK 465     UNK S    76                                                      
REMARK 465     UNK S    77                                                      
REMARK 465     UNK S    78                                                      
REMARK 465     UNK S    79                                                      
REMARK 465     UNK S    80                                                      
REMARK 465     UNK S    81                                                      
REMARK 465     UNK S    82                                                      
REMARK 465     UNK S    83                                                      
REMARK 465     UNK S    84                                                      
REMARK 465     UNK S    85                                                      
REMARK 465     UNK S    86                                                      
REMARK 465     UNK S    87                                                      
REMARK 465     UNK S    88                                                      
REMARK 465     UNK S    89                                                      
REMARK 465     UNK S    90                                                      
REMARK 465     UNK S    91                                                      
REMARK 465     UNK S    92                                                      
REMARK 465     UNK S    93                                                      
REMARK 465     UNK S    94                                                      
REMARK 465     UNK S    95                                                      
REMARK 465     UNK S    96                                                      
REMARK 465     UNK S    97                                                      
REMARK 465     UNK S    98                                                      
REMARK 465     UNK S    99                                                      
REMARK 465     UNK S   100                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   NZ   LYS B  1407     O    ARG B  1460              1.77            
REMARK 500   O    ASP B  2872     NZ   LYS B  2913              1.80            
REMARK 500   O    ASN B  1931     NH2  ARG B  1938              1.80            
REMARK 500   OE2  GLU B  2960     NH1  ARG B  3289              1.83            
REMARK 500   O    GLU B  1343     OG1  THR B  1347              1.88            
REMARK 500   NZ   LYS B  2991     OE2  GLU B  2995              1.91            
REMARK 500   NZ   LYS A   963     OG1  THR A  1006              1.92            
REMARK 500   O    ILE B  3917     NZ   LYS B  4048              1.92            
REMARK 500   OH   TYR A   527     O    ALA A   615              1.93            
REMARK 500   O    LEU A  2563     OG   SER A  2567              1.93            
REMARK 500   O    PHE A  2043     OG1  THR A  2047              1.93            
REMARK 500   O    ILE A  1491     NH1  ARG A  1497              1.93            
REMARK 500   O    LEU B   725     OG   SER B   728              1.94            
REMARK 500   OG1  THR A  3819     NH1  ARG A  3889              1.96            
REMARK 500   O    MSE B  3044     OG   SER B  3047              1.96            
REMARK 500   NZ   LYS B   963     OG1  THR B  1006              1.96            
REMARK 500   O    LEU B  3699     NH1  ARG B  3718              1.97            
REMARK 500   NH1  ARG B  2228     OD1  ASP B  2269              1.98            
REMARK 500   N    GLU B  1093     OE2  GLU B  1097              1.98            
REMARK 500   O    ARG A  3872     OG   SER A  3876              1.98            
REMARK 500   O    LEU B  1877     OH   TYR B  1920              1.98            
REMARK 500   O    ARG A  3923     NH1  ARG A  3962              1.98            
REMARK 500   O    LEU A   725     OG   SER A   728              1.99            
REMARK 500   OD1  ASN B  1435     NZ   LYS B  1489              1.99            
REMARK 500   OG1  THR B  3819     NH1  ARG B  3889              2.00            
REMARK 500   NZ   LYS B   801     OD2  ASP B   877              2.00            
REMARK 500   O    GLN A  2351     OG1  THR A  2355              2.00            
REMARK 500   O    ARG B  3872     OG   SER B  3876              2.00            
REMARK 500   O    PHE A  3904     OG   SER A  3907              2.01            
REMARK 500   O    SER B  3684     OG   SER B  3688              2.01            
REMARK 500   O    SER A   552     OG   SER A   556              2.02            
REMARK 500   O    ILE A   363     N    GLY A   367              2.03            
REMARK 500   O    LEU A  2364     OG1  THR A  2368              2.03            
REMARK 500   O    GLU B   429     N    TYR B   431              2.04            
REMARK 500   O    MSE A  3044     OG   SER A  3047              2.04            
REMARK 500   O    ILE B   741     N    ASP B   744              2.05            
REMARK 500   O    ILE A  1106     N    SER A  1110              2.05            
REMARK 500   O    HIS B  1552     ND1  HIS B  1555              2.05            
REMARK 500   NH1  ARG A  3696     O    ALA A  3720              2.05            
REMARK 500   O    GLU A   429     N    TYR A   431              2.06            
REMARK 500   ND2  ASN A  3772     O    LEU A  3788              2.06            
REMARK 500   O    ASN A  1931     NH2  ARG A  1938              2.06            
REMARK 500   O    ASP A  2571     OG   SER A  2789              2.06            
REMARK 500   O    LEU B  2563     OG   SER B  2567              2.06            
REMARK 500   O    ARG B  3923     NH1  ARG B  3962              2.07            
REMARK 500   O    LEU B  3910     OG   SER B  3914              2.07            
REMARK 500   O    GLN B  2351     OG1  THR B  2355              2.07            
REMARK 500   OE1  GLN B   591     NH1  ARG B  1026              2.08            
REMARK 500   OE1  GLN A  1603     NH2  ARG A  1606              2.08            
REMARK 500   O    PHE B  3632     N    GLY B  3637              2.08            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     132 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    HIS A1069   C     PRO A1070   N      -0.183                       
REMARK 500    HIS B1069   C     PRO B1070   N       0.146                       
REMARK 500    VAL B3794   C     PRO B3795   N      -0.157                       
REMARK 500    TRP B4124   CB    TRP B4124   CG     -0.111                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A 455   CA  -  CB  -  CG  ANGL. DEV. =  14.4 DEGREES          
REMARK 500    CYS A 458   CA  -  CB  -  SG  ANGL. DEV. =   6.9 DEGREES          
REMARK 500    MSE A 718   CB  -  CG  - SE   ANGL. DEV. = -18.1 DEGREES          
REMARK 500    LEU A 726   CA  -  CB  -  CG  ANGL. DEV. = -23.5 DEGREES          
REMARK 500    LEU A1010   CA  -  CB  -  CG  ANGL. DEV. =  19.2 DEGREES          
REMARK 500    LEU A1025   CA  -  CB  -  CG  ANGL. DEV. = -15.7 DEGREES          
REMARK 500    LEU A1111   CA  -  CB  -  CG  ANGL. DEV. = -14.3 DEGREES          
REMARK 500    LEU A1145   CA  -  CB  -  CG  ANGL. DEV. =  14.1 DEGREES          
REMARK 500    LEU A1165   CA  -  CB  -  CG  ANGL. DEV. =  17.6 DEGREES          
REMARK 500    LEU A1524   CA  -  CB  -  CG  ANGL. DEV. =  14.1 DEGREES          
REMARK 500    LEU A1976   CB  -  CG  -  CD1 ANGL. DEV. = -12.6 DEGREES          
REMARK 500    LEU A2241   CA  -  CB  -  CG  ANGL. DEV. = -14.2 DEGREES          
REMARK 500    PRO A2286   C   -  N   -  CD  ANGL. DEV. = -12.7 DEGREES          
REMARK 500    LEU A2542   CA  -  CB  -  CG  ANGL. DEV. =  17.3 DEGREES          
REMARK 500    LEU A2926   CA  -  CB  -  CG  ANGL. DEV. =  20.4 DEGREES          
REMARK 500    LEU A3321   CB  -  CG  -  CD2 ANGL. DEV. = -11.7 DEGREES          
REMARK 500    LEU A3456   CA  -  CB  -  CG  ANGL. DEV. =  21.4 DEGREES          
REMARK 500    LEU A3480   CA  -  CB  -  CG  ANGL. DEV. =  14.4 DEGREES          
REMARK 500    LEU A3575   CA  -  CB  -  CG  ANGL. DEV. =  17.8 DEGREES          
REMARK 500    MSE A3665   CB  -  CG  - SE   ANGL. DEV. =  18.7 DEGREES          
REMARK 500    LEU A3788   CA  -  CB  -  CG  ANGL. DEV. = -15.8 DEGREES          
REMARK 500    LEU A3882   CA  -  CB  -  CG  ANGL. DEV. = -18.7 DEGREES          
REMARK 500    LEU B 220   CA  -  CB  -  CG  ANGL. DEV. =  15.0 DEGREES          
REMARK 500    ARG B 515   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.2 DEGREES          
REMARK 500    LEU B 726   CA  -  CB  -  CG  ANGL. DEV. = -21.0 DEGREES          
REMARK 500    LEU B 862   CB  -  CG  -  CD2 ANGL. DEV. = -10.6 DEGREES          
REMARK 500    LEU B 942   CB  -  CG  -  CD1 ANGL. DEV. = -10.2 DEGREES          
REMARK 500    LEU B1009   CB  -  CG  -  CD1 ANGL. DEV. = -15.9 DEGREES          
REMARK 500    LEU B1010   CA  -  CB  -  CG  ANGL. DEV. =  20.7 DEGREES          
REMARK 500    LEU B1165   CA  -  CB  -  CG  ANGL. DEV. =  17.2 DEGREES          
REMARK 500    LEU B1580   CA  -  CB  -  CG  ANGL. DEV. =  14.3 DEGREES          
REMARK 500    LEU B1695   CA  -  CB  -  CG  ANGL. DEV. =  16.6 DEGREES          
REMARK 500    LEU B1717   CA  -  CB  -  CG  ANGL. DEV. = -15.8 DEGREES          
REMARK 500    LEU B1812   CA  -  CB  -  CG  ANGL. DEV. =  14.1 DEGREES          
REMARK 500    LEU B1984   CA  -  CB  -  CG  ANGL. DEV. =  14.2 DEGREES          
REMARK 500    PRO B2287   C   -  N   -  CD  ANGL. DEV. = -12.7 DEGREES          
REMARK 500    LEU B2542   CA  -  CB  -  CG  ANGL. DEV. =  18.3 DEGREES          
REMARK 500    LEU B2892   CA  -  CB  -  CG  ANGL. DEV. =  14.1 DEGREES          
REMARK 500    LEU B2921   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    GLN B3397   CA  -  CB  -  CG  ANGL. DEV. =  14.3 DEGREES          
REMARK 500    LEU B3416   CA  -  CB  -  CG  ANGL. DEV. =  13.9 DEGREES          
REMARK 500    LEU B3456   CA  -  CB  -  CG  ANGL. DEV. =  22.2 DEGREES          
REMARK 500    LEU B3667   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    LEU B4051   CA  -  CB  -  CG  ANGL. DEV. =  15.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ALA A  27     -138.15   -166.44                                   
REMARK 500    ALA A  28     -133.22     77.10                                   
REMARK 500    ALA A  30        0.28    -54.30                                   
REMARK 500    LEU A  44       -5.83    -55.86                                   
REMARK 500    SER A  46      -80.33   -105.62                                   
REMARK 500    PRO A  48     -138.94    -79.32                                   
REMARK 500    ALA A  49      -79.30     37.39                                   
REMARK 500    VAL A  50      -74.07    -64.18                                   
REMARK 500    VAL A  67      -71.67    -54.90                                   
REMARK 500    VAL A  69      -74.18    -62.01                                   
REMARK 500    LEU A  73     -110.01   -118.53                                   
REMARK 500    ASN A  74     -142.34   -166.77                                   
REMARK 500    SER A  75      -92.72   -115.48                                   
REMARK 500    ILE A  76      -74.82     33.11                                   
REMARK 500    GLU A  77       -6.58   -141.53                                   
REMARK 500    GLN A  98     -113.20   -104.95                                   
REMARK 500    ILE A 100       36.43   -143.57                                   
REMARK 500    CYS A 123     -140.57     60.07                                   
REMARK 500    LYS A 124     -169.45     61.05                                   
REMARK 500    MSE A 144     -138.37     51.47                                   
REMARK 500    GLU A 146      -99.02   -122.87                                   
REMARK 500    PHE A 147      -86.64    177.24                                   
REMARK 500    LEU A 162       -8.52    -58.39                                   
REMARK 500    LYS A 164      125.63    179.03                                   
REMARK 500    LYS A 165       45.13    -96.36                                   
REMARK 500    PRO A 167      -98.94    -58.06                                   
REMARK 500    ASP A 168      -36.18   -141.39                                   
REMARK 500    THR A 169       37.64    -63.70                                   
REMARK 500    VAL A 170      -43.17   -169.62                                   
REMARK 500    VAL A 184     -116.06    -70.30                                   
REMARK 500    HIS A 185      -34.75   -153.79                                   
REMARK 500    PRO A 186       93.38    -26.64                                   
REMARK 500    SER A 187      -83.49    -31.48                                   
REMARK 500    THR A 235     -170.95     69.27                                   
REMARK 500    MSE A 238      -18.21   -147.34                                   
REMARK 500    GLU A 239      -43.27   -144.24                                   
REMARK 500    SER A 245      -70.27    -56.19                                   
REMARK 500    LEU A 253       32.81    -73.67                                   
REMARK 500    LYS A 254      -77.23   -132.83                                   
REMARK 500    ALA A 255      156.82     63.06                                   
REMARK 500    ILE A 256      -87.35   -135.73                                   
REMARK 500    ARG A 257      -31.46   -130.92                                   
REMARK 500    ILE A 260       -1.63     69.19                                   
REMARK 500    ALA A 276       84.05    -49.31                                   
REMARK 500    LEU A 277      -90.75   -157.34                                   
REMARK 500    LEU A 286       56.36   -100.71                                   
REMARK 500    ASP A 288      -59.89   -148.32                                   
REMARK 500    LEU A 298      -73.80    -54.19                                   
REMARK 500    LEU A 316      -70.41    -56.76                                   
REMARK 500    ASN A 325      -85.68    -42.17                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS    1174 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 PRO A  411     SER A  412                  145.74                    
REMARK 500 LEU A  634     PRO A  635                  143.84                    
REMARK 500 SER A 1323     PRO A 1324                 -142.40                    
REMARK 500 ASN A 2283     ASP A 2284                  149.52                    
REMARK 500 PRO A 2372     PRO A 2373                 -129.42                    
REMARK 500 THR A 3547     GLY A 3548                  143.19                    
REMARK 500 MSE A 3980     TYR A 3981                  144.88                    
REMARK 500 ARG A 4119     THR A 4120                 -141.57                    
REMARK 500 PRO B  411     SER B  412                  143.34                    
REMARK 500 LEU B  634     PRO B  635                  147.22                    
REMARK 500 SER B 1323     PRO B 1324                 -136.52                    
REMARK 500 PRO B 2372     PRO B 2373                 -133.52                    
REMARK 500 THR B 3547     GLY B 3548                  146.49                    
REMARK 500 ARG B 4119     THR B 4120                 -148.68                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  5LUQ A    2  2575  UNP    P78527   PRKDC_HUMAN      2   2575             
DBREF  5LUQ A 2576  2773  PDB    5LUQ     5LUQ          2576   2773             
DBREF  5LUQ A 2774  4127  UNP    P78527   PRKDC_HUMAN   2774   4127             
DBREF  5LUQ K  -39   221  PDB    5LUQ     5LUQ           -39    221             
DBREF  5LUQ B    2  2575  UNP    P78527   PRKDC_HUMAN      2   2575             
DBREF  5LUQ B 2576  2773  PDB    5LUQ     5LUQ          2576   2773             
DBREF  5LUQ B 2774  4127  UNP    P78527   PRKDC_HUMAN   2774   4127             
DBREF  5LUQ S  -39   221  PDB    5LUQ     5LUQ           -39    221             
SEQADV 5LUQ MSE A    1  UNP  P78527              EXPRESSION TAG                 
SEQADV 5LUQ MSE A 4128  UNP  P78527              EXPRESSION TAG                 
SEQADV 5LUQ MSE B    1  UNP  P78527              EXPRESSION TAG                 
SEQADV 5LUQ MSE B 4128  UNP  P78527              EXPRESSION TAG                 
SEQRES   1 A 4128  MSE ALA GLY SER GLY ALA GLY VAL ARG CYS SER LEU LEU          
SEQRES   2 A 4128  ARG LEU GLN GLU THR LEU SER ALA ALA ASP ARG CYS GLY          
SEQRES   3 A 4128  ALA ALA LEU ALA GLY HIS GLN LEU ILE ARG GLY LEU GLY          
SEQRES   4 A 4128  GLN GLU CYS VAL LEU SER SER SER PRO ALA VAL LEU ALA          
SEQRES   5 A 4128  LEU GLN THR SER LEU VAL PHE SER ARG ASP PHE GLY LEU          
SEQRES   6 A 4128  LEU VAL PHE VAL ARG LYS SER LEU ASN SER ILE GLU PHE          
SEQRES   7 A 4128  ARG GLU CYS ARG GLU GLU ILE LEU LYS PHE LEU CYS ILE          
SEQRES   8 A 4128  PHE LEU GLU LYS MSE GLY GLN LYS ILE ALA PRO TYR SER          
SEQRES   9 A 4128  VAL GLU ILE LYS ASN THR CYS THR SER VAL TYR THR LYS          
SEQRES  10 A 4128  ASP ARG ALA ALA LYS CYS LYS ILE PRO ALA LEU ASP LEU          
SEQRES  11 A 4128  LEU ILE LYS LEU LEU GLN THR PHE ARG SER SER ARG LEU          
SEQRES  12 A 4128  MSE ASP GLU PHE LYS ILE GLY GLU LEU PHE SER LYS PHE          
SEQRES  13 A 4128  TYR GLY GLU LEU ALA LEU LYS LYS LYS ILE PRO ASP THR          
SEQRES  14 A 4128  VAL LEU GLU LYS VAL TYR GLU LEU LEU GLY LEU LEU GLY          
SEQRES  15 A 4128  GLU VAL HIS PRO SER GLU MSE ILE ASN ASN ALA GLU ASN          
SEQRES  16 A 4128  LEU PHE ARG ALA PHE LEU GLY GLU LEU LYS THR GLN MSE          
SEQRES  17 A 4128  THR SER ALA VAL ARG GLU PRO LYS LEU PRO VAL LEU ALA          
SEQRES  18 A 4128  GLY CYS LEU LYS GLY LEU SER SER LEU LEU CYS ASN PHE          
SEQRES  19 A 4128  THR LYS SER MSE GLU GLU ASP PRO GLN THR SER ARG GLU          
SEQRES  20 A 4128  ILE PHE ASN PHE VAL LEU LYS ALA ILE ARG PRO GLN ILE          
SEQRES  21 A 4128  ASP LEU LYS ARG TYR ALA VAL PRO SER ALA GLY LEU ARG          
SEQRES  22 A 4128  LEU PHE ALA LEU HIS ALA SER GLN PHE SER THR CYS LEU          
SEQRES  23 A 4128  LEU ASP ASN TYR VAL SER LEU PHE GLU VAL LEU LEU LYS          
SEQRES  24 A 4128  TRP CYS ALA HIS THR ASN VAL GLU LEU LYS LYS ALA ALA          
SEQRES  25 A 4128  LEU SER ALA LEU GLU SER PHE LEU LYS GLN VAL SER ASN          
SEQRES  26 A 4128  MSE VAL ALA LYS ASN ALA GLU MSE HIS LYS ASN LYS LEU          
SEQRES  27 A 4128  GLN TYR PHE MSE GLU GLN PHE TYR GLY ILE ILE ARG ASN          
SEQRES  28 A 4128  VAL ASP SER ASN ASN LYS GLU LEU SER ILE ALA ILE ARG          
SEQRES  29 A 4128  GLY TYR GLY LEU PHE ALA GLY PRO CYS LYS VAL ILE ASN          
SEQRES  30 A 4128  ALA LYS ASP VAL ASP PHE MSE TYR VAL GLU LEU ILE GLN          
SEQRES  31 A 4128  ARG CYS LYS GLN MSE PHE LEU THR GLN THR ASP THR GLY          
SEQRES  32 A 4128  ASP ASP ARG VAL TYR GLN MSE PRO SER PHE LEU GLN SER          
SEQRES  33 A 4128  VAL ALA SER VAL LEU LEU TYR LEU ASP THR VAL PRO GLU          
SEQRES  34 A 4128  VAL TYR THR PRO VAL LEU GLU HIS LEU VAL VAL MSE GLN          
SEQRES  35 A 4128  ILE ASP SER PHE PRO GLN TYR SER PRO LYS MSE GLN LEU          
SEQRES  36 A 4128  VAL CYS CYS ARG ALA ILE VAL LYS VAL PHE LEU ALA LEU          
SEQRES  37 A 4128  ALA ALA LYS GLY PRO VAL LEU ARG ASN CYS ILE SER THR          
SEQRES  38 A 4128  VAL VAL HIS GLN GLY LEU ILE ARG ILE CYS SER LYS PRO          
SEQRES  39 A 4128  VAL VAL LEU PRO LYS GLY PRO GLU SER GLU SER GLU ASP          
SEQRES  40 A 4128  HIS ARG ALA SER GLY GLU VAL ARG THR GLY LYS TRP LYS          
SEQRES  41 A 4128  VAL PRO THR TYR LYS ASP TYR VAL ASP LEU PHE ARG HIS          
SEQRES  42 A 4128  LEU LEU SER SER ASP GLN MSE MSE ASP SER ILE LEU ALA          
SEQRES  43 A 4128  ASP GLU ALA PHE PHE SER VAL ASN SER SER SER GLU SER          
SEQRES  44 A 4128  LEU ASN HIS LEU LEU TYR ASP GLU PHE VAL LYS SER VAL          
SEQRES  45 A 4128  LEU LYS ILE VAL GLU LYS LEU ASP LEU THR LEU GLU ILE          
SEQRES  46 A 4128  GLN THR VAL GLY GLU GLN GLU ASN GLY ASP GLU ALA PRO          
SEQRES  47 A 4128  GLY VAL TRP MSE ILE PRO THR SER ASP PRO ALA ALA ASN          
SEQRES  48 A 4128  LEU HIS PRO ALA LYS PRO LYS ASP PHE SER ALA PHE ILE          
SEQRES  49 A 4128  ASN LEU VAL GLU PHE CYS ARG GLU ILE LEU PRO GLU LYS          
SEQRES  50 A 4128  GLN ALA GLU PHE PHE GLU PRO TRP VAL TYR SER PHE SER          
SEQRES  51 A 4128  TYR GLU LEU ILE LEU GLN SER THR ARG LEU PRO LEU ILE          
SEQRES  52 A 4128  SER GLY PHE TYR LYS LEU LEU SER ILE THR VAL ARG ASN          
SEQRES  53 A 4128  ALA LYS LYS ILE LYS TYR PHE GLU GLY VAL SER PRO LYS          
SEQRES  54 A 4128  SER LEU LYS HIS SER PRO GLU ASP PRO GLU LYS TYR SER          
SEQRES  55 A 4128  CYS PHE ALA LEU PHE VAL LYS PHE GLY LYS GLU VAL ALA          
SEQRES  56 A 4128  VAL LYS MSE LYS GLN TYR LYS ASP GLU LEU LEU ALA SER          
SEQRES  57 A 4128  CYS LEU THR PHE LEU LEU SER LEU PRO HIS ASN ILE ILE          
SEQRES  58 A 4128  GLU LEU ASP VAL ARG ALA TYR VAL PRO ALA LEU GLN MSE          
SEQRES  59 A 4128  ALA PHE LYS LEU GLY LEU SER TYR THR PRO LEU ALA GLU          
SEQRES  60 A 4128  VAL GLY LEU ASN ALA LEU GLU GLU TRP SER ILE TYR ILE          
SEQRES  61 A 4128  ASP ARG HIS VAL MSE GLN PRO TYR TYR LYS ASP ILE LEU          
SEQRES  62 A 4128  PRO CYS LEU ASP GLY TYR LEU LYS THR SER ALA LEU SER          
SEQRES  63 A 4128  ASP GLU THR LYS ASN ASN TRP GLU VAL SER ALA LEU SER          
SEQRES  64 A 4128  ARG ALA ALA GLN LYS GLY PHE ASN LYS VAL VAL LEU LYS          
SEQRES  65 A 4128  HIS LEU LYS LYS THR LYS ASN LEU SER SER ASN GLU ALA          
SEQRES  66 A 4128  ILE SER LEU GLU GLU ILE ARG ILE ARG VAL VAL GLN MSE          
SEQRES  67 A 4128  LEU GLY SER LEU GLY GLY GLN ILE ASN LYS ASN LEU LEU          
SEQRES  68 A 4128  THR VAL THR SER SER ASP GLU MSE MSE LYS SER TYR VAL          
SEQRES  69 A 4128  ALA TRP ASP ARG GLU LYS ARG LEU SER PHE ALA VAL PRO          
SEQRES  70 A 4128  PHE ARG GLU MSE LYS PRO VAL ILE PHE LEU ASP VAL PHE          
SEQRES  71 A 4128  LEU PRO ARG VAL THR GLU LEU ALA LEU THR ALA SER ASP          
SEQRES  72 A 4128  ARG GLN THR LYS VAL ALA ALA CYS GLU LEU LEU HIS SER          
SEQRES  73 A 4128  MSE VAL MSE PHE MSE LEU GLY LYS ALA THR GLN MSE PRO          
SEQRES  74 A 4128  GLU GLY GLY GLN GLY ALA PRO PRO MSE TYR GLN LEU TYR          
SEQRES  75 A 4128  LYS ARG THR PHE PRO VAL LEU LEU ARG LEU ALA CYS ASP          
SEQRES  76 A 4128  VAL ASP GLN VAL THR ARG GLN LEU TYR GLU PRO LEU VAL          
SEQRES  77 A 4128  MSE GLN LEU ILE HIS TRP PHE THR ASN ASN LYS LYS PHE          
SEQRES  78 A 4128  GLU SER GLN ASP THR VAL ALA LEU LEU GLU ALA ILE LEU          
SEQRES  79 A 4128  ASP GLY ILE VAL ASP PRO VAL ASP SER THR LEU ARG ASP          
SEQRES  80 A 4128  PHE CYS GLY ARG CYS ILE ARG GLU PHE LEU LYS TRP SER          
SEQRES  81 A 4128  ILE LYS GLN ILE THR PRO GLN GLN GLN GLU LYS SER PRO          
SEQRES  82 A 4128  VAL ASN THR LYS SER LEU PHE LYS ARG LEU TYR SER LEU          
SEQRES  83 A 4128  ALA LEU HIS PRO ASN ALA PHE LYS ARG LEU GLY ALA SER          
SEQRES  84 A 4128  LEU ALA PHE ASN ASN ILE TYR ARG GLU PHE ARG GLU GLU          
SEQRES  85 A 4128  GLU SER LEU VAL GLU GLN PHE VAL PHE GLU ALA LEU VAL          
SEQRES  86 A 4128  ILE TYR MSE GLU SER LEU ALA LEU ALA HIS ALA ASP GLU          
SEQRES  87 A 4128  LYS SER LEU GLY THR ILE GLN GLN CYS CYS ASP ALA ILE          
SEQRES  88 A 4128  ASP HIS LEU CYS ARG ILE ILE GLU LYS LYS HIS VAL SER          
SEQRES  89 A 4128  LEU ASN LYS ALA LYS LYS ARG ARG LEU PRO ARG GLY PHE          
SEQRES  90 A 4128  PRO PRO SER ALA SER LEU CYS LEU LEU ASP LEU VAL LYS          
SEQRES  91 A 4128  TRP LEU LEU ALA HIS CYS GLY ARG PRO GLN THR GLU CYS          
SEQRES  92 A 4128  ARG HIS LYS SER ILE GLU LEU PHE TYR LYS PHE VAL PRO          
SEQRES  93 A 4128  LEU LEU PRO GLY ASN ARG SER PRO ASN LEU TRP LEU LYS          
SEQRES  94 A 4128  ASP VAL LEU LYS GLU GLU GLY VAL SER PHE LEU ILE ASN          
SEQRES  95 A 4128  THR PHE GLU GLY GLY GLY CYS GLY GLN PRO SER GLY ILE          
SEQRES  96 A 4128  LEU ALA GLN PRO THR LEU LEU TYR LEU ARG GLY PRO PHE          
SEQRES  97 A 4128  SER LEU GLN ALA THR LEU CYS TRP LEU ASP LEU LEU LEU          
SEQRES  98 A 4128  ALA ALA LEU GLU CYS TYR ASN THR PHE ILE GLY GLU ARG          
SEQRES  99 A 4128  THR VAL GLY ALA LEU GLN VAL LEU GLY THR GLU ALA GLN          
SEQRES 100 A 4128  SER SER LEU LEU LYS ALA VAL ALA PHE PHE LEU GLU SER          
SEQRES 101 A 4128  ILE ALA MSE HIS ASP ILE ILE ALA ALA GLU LYS CYS PHE          
SEQRES 102 A 4128  GLY THR GLY ALA ALA GLY ASN ARG THR SER PRO GLN GLU          
SEQRES 103 A 4128  GLY GLU ARG TYR ASN TYR SER LYS CYS THR VAL VAL VAL          
SEQRES 104 A 4128  ARG ILE MSE GLU PHE THR THR THR LEU LEU ASN THR SER          
SEQRES 105 A 4128  PRO GLU GLY TRP LYS LEU LEU LYS LYS ASP LEU CYS ASN          
SEQRES 106 A 4128  THR HIS LEU MSE ARG VAL LEU VAL GLN THR LEU CYS GLU          
SEQRES 107 A 4128  PRO ALA SER ILE GLY PHE ASN ILE GLY ASP VAL GLN VAL          
SEQRES 108 A 4128  MSE ALA HIS LEU PRO ASP VAL CYS VAL ASN LEU MSE LYS          
SEQRES 109 A 4128  ALA LEU LYS MSE SER PRO TYR LYS ASP ILE LEU GLU THR          
SEQRES 110 A 4128  HIS LEU ARG GLU LYS ILE THR ALA GLN SER ILE GLU GLU          
SEQRES 111 A 4128  LEU CYS ALA VAL ASN LEU TYR GLY PRO ASP ALA GLN VAL          
SEQRES 112 A 4128  ASP ARG SER ARG LEU ALA ALA VAL VAL SER ALA CYS LYS          
SEQRES 113 A 4128  GLN LEU HIS ARG ALA GLY LEU LEU HIS ASN ILE LEU PRO          
SEQRES 114 A 4128  SER GLN SER THR ASP LEU HIS HIS SER VAL GLY THR GLU          
SEQRES 115 A 4128  LEU LEU SER LEU VAL TYR LYS GLY ILE ALA PRO GLY ASP          
SEQRES 116 A 4128  GLU ARG GLN CYS LEU PRO SER LEU ASP LEU SER CYS LYS          
SEQRES 117 A 4128  GLN LEU ALA SER GLY LEU LEU GLU LEU ALA PHE ALA PHE          
SEQRES 118 A 4128  GLY GLY LEU CYS GLU ARG LEU VAL SER LEU LEU LEU ASN          
SEQRES 119 A 4128  PRO ALA VAL LEU SER THR ALA SER LEU GLY SER SER GLN          
SEQRES 120 A 4128  GLY SER VAL ILE HIS PHE SER HIS GLY GLU TYR PHE TYR          
SEQRES 121 A 4128  SER LEU PHE SER GLU THR ILE ASN THR GLU LEU LEU LYS          
SEQRES 122 A 4128  ASN LEU ASP LEU ALA VAL LEU GLU LEU MSE GLN SER SER          
SEQRES 123 A 4128  VAL ASP ASN THR LYS MSE VAL SER ALA VAL LEU ASN GLY          
SEQRES 124 A 4128  MSE LEU ASP GLN SER PHE ARG GLU ARG ALA ASN GLN LYS          
SEQRES 125 A 4128  HIS GLN GLY LEU LYS LEU ALA THR THR ILE LEU GLN HIS          
SEQRES 126 A 4128  TRP LYS LYS CYS ASP SER TRP TRP ALA LYS ASP SER PRO          
SEQRES 127 A 4128  LEU GLU THR LYS MSE ALA VAL LEU ALA LEU LEU ALA LYS          
SEQRES 128 A 4128  ILE LEU GLN ILE ASP SER SER VAL SER PHE ASN THR SER          
SEQRES 129 A 4128  HIS GLY SER PHE PRO GLU VAL PHE THR THR TYR ILE SER          
SEQRES 130 A 4128  LEU LEU ALA ASP THR LYS LEU ASP LEU HIS LEU LYS GLY          
SEQRES 131 A 4128  GLN ALA VAL THR LEU LEU PRO PHE PHE THR SER LEU THR          
SEQRES 132 A 4128  GLY GLY SER LEU GLU GLU LEU ARG ARG VAL LEU GLU GLN          
SEQRES 133 A 4128  LEU ILE VAL ALA HIS PHE PRO MSE GLN SER ARG GLU PHE          
SEQRES 134 A 4128  PRO PRO GLY THR PRO ARG PHE ASN ASN TYR VAL ASP CYS          
SEQRES 135 A 4128  MSE LYS LYS PHE LEU ASP ALA LEU GLU LEU SER GLN SER          
SEQRES 136 A 4128  PRO MSE LEU LEU GLU LEU MSE THR GLU VAL LEU CYS ARG          
SEQRES 137 A 4128  GLU GLN GLN HIS VAL MSE GLU GLU LEU PHE GLN SER SER          
SEQRES 138 A 4128  PHE ARG ARG ILE ALA ARG ARG GLY SER CYS VAL THR GLN          
SEQRES 139 A 4128  VAL GLY LEU LEU GLU SER VAL TYR GLU MSE PHE ARG LYS          
SEQRES 140 A 4128  ASP ASP PRO ARG LEU SER PHE THR ARG GLN SER PHE VAL          
SEQRES 141 A 4128  ASP ARG SER LEU LEU THR LEU LEU TRP HIS CYS SER LEU          
SEQRES 142 A 4128  ASP ALA LEU ARG GLU PHE PHE SER THR ILE VAL VAL ASP          
SEQRES 143 A 4128  ALA ILE ASP VAL LEU LYS SER ARG PHE THR LYS LEU ASN          
SEQRES 144 A 4128  GLU SER THR PHE ASP THR GLN ILE THR LYS LYS MSE GLY          
SEQRES 145 A 4128  TYR TYR LYS ILE LEU ASP VAL MSE TYR SER ARG LEU PRO          
SEQRES 146 A 4128  LYS ASP ASP VAL HIS ALA LYS GLU SER LYS ILE ASN GLN          
SEQRES 147 A 4128  VAL PHE HIS GLY SER CYS ILE THR GLU GLY ASN GLU LEU          
SEQRES 148 A 4128  THR LYS THR LEU ILE LYS LEU CYS TYR ASP ALA PHE THR          
SEQRES 149 A 4128  GLU ASN MSE ALA GLY GLU ASN GLN LEU LEU GLU ARG ARG          
SEQRES 150 A 4128  ARG LEU TYR HIS CYS ALA ALA TYR ASN CYS ALA ILE SER          
SEQRES 151 A 4128  VAL ILE CYS CYS VAL PHE ASN GLU LEU LYS PHE TYR GLN          
SEQRES 152 A 4128  GLY PHE LEU PHE SER GLU LYS PRO GLU LYS ASN LEU LEU          
SEQRES 153 A 4128  ILE PHE GLU ASN LEU ILE ASP LEU LYS ARG ARG TYR ASN          
SEQRES 154 A 4128  PHE PRO VAL GLU VAL GLU VAL PRO MSE GLU ARG LYS LYS          
SEQRES 155 A 4128  LYS TYR ILE GLU ILE ARG LYS GLU ALA ARG GLU ALA ALA          
SEQRES 156 A 4128  ASN GLY ASP SER ASP GLY PRO SER TYR MSE SER SER LEU          
SEQRES 157 A 4128  SER TYR LEU ALA ASP SER THR LEU SER GLU GLU MSE SER          
SEQRES 158 A 4128  GLN PHE ASP PHE SER THR GLY VAL GLN SER TYR SER TYR          
SEQRES 159 A 4128  SER SER GLN ASP PRO ARG PRO ALA THR GLY ARG PHE ARG          
SEQRES 160 A 4128  ARG ARG GLU GLN ARG ASP PRO THR VAL HIS ASP ASP VAL          
SEQRES 161 A 4128  LEU GLU LEU GLU MSE ASP GLU LEU ASN ARG HIS GLU CYS          
SEQRES 162 A 4128  MSE ALA PRO LEU THR ALA LEU VAL LYS HIS MSE HIS ARG          
SEQRES 163 A 4128  SER LEU GLY PRO PRO GLN GLY GLU GLU ASP SER VAL PRO          
SEQRES 164 A 4128  ARG ASP LEU PRO SER TRP MSE LYS PHE LEU HIS GLY LYS          
SEQRES 165 A 4128  LEU GLY ASN PRO ILE VAL PRO LEU ASN ILE ARG LEU PHE          
SEQRES 166 A 4128  LEU ALA LYS LEU VAL ILE ASN THR GLU GLU VAL PHE ARG          
SEQRES 167 A 4128  PRO TYR ALA LYS HIS TRP LEU SER PRO LEU LEU GLN LEU          
SEQRES 168 A 4128  ALA ALA SER GLU ASN ASN GLY GLY GLU GLY ILE HIS TYR          
SEQRES 169 A 4128  MSE VAL VAL GLU ILE VAL ALA THR ILE LEU SER TRP THR          
SEQRES 170 A 4128  GLY LEU ALA THR PRO THR GLY VAL PRO LYS ASP GLU VAL          
SEQRES 171 A 4128  LEU ALA ASN ARG LEU LEU ASN PHE LEU MSE LYS HIS VAL          
SEQRES 172 A 4128  PHE HIS PRO LYS ARG ALA VAL PHE ARG HIS ASN LEU GLU          
SEQRES 173 A 4128  ILE ILE LYS THR LEU VAL GLU CYS TRP LYS ASP CYS LEU          
SEQRES 174 A 4128  SER ILE PRO TYR ARG LEU ILE PHE GLU LYS PHE SER GLY          
SEQRES 175 A 4128  LYS ASP PRO ASN SER LYS ASP ASN SER VAL GLY ILE GLN          
SEQRES 176 A 4128  LEU LEU GLY ILE VAL MSE ALA ASN ASP LEU PRO PRO TYR          
SEQRES 177 A 4128  ASP PRO GLN CYS GLY ILE GLN SER SER GLU TYR PHE GLN          
SEQRES 178 A 4128  ALA LEU VAL ASN ASN MSE SER PHE VAL ARG TYR LYS GLU          
SEQRES 179 A 4128  VAL TYR ALA ALA ALA ALA GLU VAL LEU GLY LEU ILE LEU          
SEQRES 180 A 4128  ARG TYR VAL MSE GLU ARG LYS ASN ILE LEU GLU GLU SER          
SEQRES 181 A 4128  LEU CYS GLU LEU VAL ALA LYS GLN LEU LYS GLN HIS GLN          
SEQRES 182 A 4128  ASN THR MSE GLU ASP LYS PHE ILE VAL CYS LEU ASN LYS          
SEQRES 183 A 4128  VAL THR LYS SER PHE PRO PRO LEU ALA ASP ARG PHE MSE          
SEQRES 184 A 4128  ASN ALA VAL PHE PHE LEU LEU PRO LYS PHE HIS GLY VAL          
SEQRES 185 A 4128  LEU LYS THR LEU CYS LEU GLU VAL VAL LEU CYS ARG VAL          
SEQRES 186 A 4128  GLU GLY MSE THR GLU LEU TYR PHE GLN LEU LYS SER LYS          
SEQRES 187 A 4128  ASP PHE VAL GLN VAL MSE ARG HIS ARG ASP ASP GLU ARG          
SEQRES 188 A 4128  GLN LYS VAL CYS LEU ASP ILE ILE TYR LYS MSE MSE PRO          
SEQRES 189 A 4128  LYS LEU LYS PRO VAL GLU LEU ARG GLU LEU LEU ASN PRO          
SEQRES 190 A 4128  VAL VAL GLU PHE VAL SER HIS PRO SER THR THR CYS ARG          
SEQRES 191 A 4128  GLU GLN MSE TYR ASN ILE LEU MSE TRP ILE HIS ASP ASN          
SEQRES 192 A 4128  TYR ARG ASP PRO GLU SER GLU THR ASP ASN ASP SER GLN          
SEQRES 193 A 4128  GLU ILE PHE LYS LEU ALA LYS ASP VAL LEU ILE GLN GLY          
SEQRES 194 A 4128  LEU ILE ASP GLU ASN PRO GLY LEU GLN LEU ILE ILE ARG          
SEQRES 195 A 4128  ASN PHE TRP SER HIS GLU THR ARG LEU PRO SER ASN THR          
SEQRES 196 A 4128  LEU ASP ARG LEU LEU ALA LEU ASN SER LEU TYR SER PRO          
SEQRES 197 A 4128  LYS ILE GLU VAL HIS PHE LEU SER LEU ALA THR ASN PHE          
SEQRES 198 A 4128  LEU LEU GLU MSE THR SER MSE SER PRO ASP TYR PRO ASN          
SEQRES 199 A 4128  PRO MSE UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 200 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 201 A 4128  UNK UNK UNK UNK MSE UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 202 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 203 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 204 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 205 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 206 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 207 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 208 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 209 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 210 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 211 A 4128  UNK UNK MSE UNK UNK UNK UNK UNK UNK UNK UNK MSE UNK          
SEQRES 212 A 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 213 A 4128  UNK UNK UNK UNK UNK UNK MSE UNK UNK UNK UNK UNK UNK          
SEQRES 214 A 4128  UNK UNK UNK UNK SER TYR ARG HIS GLY ASP LEU PRO ASP          
SEQRES 215 A 4128  ILE GLN ILE LYS HIS SER SER LEU ILE THR PRO LEU GLN          
SEQRES 216 A 4128  ALA VAL ALA GLN ARG ASP PRO ILE ILE ALA LYS GLN LEU          
SEQRES 217 A 4128  PHE SER SER LEU PHE SER GLY ILE LEU LYS GLU MSE ASP          
SEQRES 218 A 4128  LYS PHE LYS THR LEU SER GLU LYS ASN ASN ILE THR GLN          
SEQRES 219 A 4128  LYS LEU LEU GLN ASP PHE ASN ARG PHE LEU ASN THR THR          
SEQRES 220 A 4128  PHE SER PHE PHE PRO PRO PHE VAL SER CYS ILE GLN ASP          
SEQRES 221 A 4128  ILE SER CYS GLN HIS ALA ALA LEU LEU SER LEU ASP PRO          
SEQRES 222 A 4128  ALA ALA VAL SER ALA GLY CYS LEU ALA SER LEU GLN GLN          
SEQRES 223 A 4128  PRO VAL GLY ILE ARG LEU LEU GLU GLU ALA LEU LEU ARG          
SEQRES 224 A 4128  LEU LEU PRO ALA GLU LEU PRO ALA LYS ARG VAL ARG GLY          
SEQRES 225 A 4128  LYS ALA ARG LEU PRO PRO ASP VAL LEU ARG TRP VAL GLU          
SEQRES 226 A 4128  LEU ALA LYS LEU TYR ARG SER ILE GLY GLU TYR ASP VAL          
SEQRES 227 A 4128  LEU ARG GLY ILE PHE THR SER GLU ILE GLY THR LYS GLN          
SEQRES 228 A 4128  ILE THR GLN SER ALA LEU LEU ALA GLU ALA ARG SER ASP          
SEQRES 229 A 4128  TYR SER GLU ALA ALA LYS GLN TYR ASP GLU ALA LEU ASN          
SEQRES 230 A 4128  LYS GLN ASP TRP VAL ASP GLY GLU PRO THR GLU ALA GLU          
SEQRES 231 A 4128  LYS ASP PHE TRP GLU LEU ALA SER LEU ASP CYS TYR ASN          
SEQRES 232 A 4128  HIS LEU ALA GLU TRP LYS SER LEU GLU TYR CYS SER THR          
SEQRES 233 A 4128  ALA SER ILE ASP SER GLU ASN PRO PRO ASP LEU ASN LYS          
SEQRES 234 A 4128  ILE TRP SER GLU PRO PHE TYR GLN GLU THR TYR LEU PRO          
SEQRES 235 A 4128  TYR MSE ILE ARG SER LYS LEU LYS LEU LEU LEU GLN GLY          
SEQRES 236 A 4128  GLU ALA ASP GLN SER LEU LEU THR PHE ILE ASP LYS ALA          
SEQRES 237 A 4128  MSE HIS GLY GLU LEU GLN LYS ALA ILE LEU GLU LEU HIS          
SEQRES 238 A 4128  TYR SER GLN GLU LEU SER LEU LEU TYR LEU LEU GLN ASP          
SEQRES 239 A 4128  ASP VAL ASP ARG ALA LYS TYR TYR ILE GLN ASN GLY ILE          
SEQRES 240 A 4128  GLN SER PHE MSE GLN ASN TYR SER SER ILE ASP VAL LEU          
SEQRES 241 A 4128  LEU HIS GLN SER ARG LEU THR LYS LEU GLN SER VAL GLN          
SEQRES 242 A 4128  ALA LEU THR GLU ILE GLN GLU PHE ILE SER PHE ILE SER          
SEQRES 243 A 4128  LYS GLN GLY ASN LEU SER SER GLN VAL PRO LEU LYS ARG          
SEQRES 244 A 4128  LEU LEU ASN THR TRP THR ASN ARG TYR PRO ASP ALA LYS          
SEQRES 245 A 4128  MSE ASP PRO MSE ASN ILE TRP ASP ASP ILE ILE THR ASN          
SEQRES 246 A 4128  ARG CYS PHE PHE LEU SER LYS ILE GLU GLU LYS LEU THR          
SEQRES 247 A 4128  PRO LEU PRO GLU ASP ASN SER MSE ASN VAL ASP GLN ASP          
SEQRES 248 A 4128  GLY ASP PRO SER ASP ARG MSE GLU VAL GLN GLU GLN GLU          
SEQRES 249 A 4128  GLU ASP ILE SER SER LEU ILE ARG SER CYS LYS PHE SER          
SEQRES 250 A 4128  MSE LYS MSE LYS MSE ILE ASP SER ALA ARG LYS GLN ASN          
SEQRES 251 A 4128  ASN PHE SER LEU ALA MSE LYS LEU LEU LYS GLU LEU HIS          
SEQRES 252 A 4128  LYS GLU SER LYS THR ARG ASP ASP TRP LEU VAL SER TRP          
SEQRES 253 A 4128  VAL GLN SER TYR CYS ARG LEU SER HIS CYS ARG SER ARG          
SEQRES 254 A 4128  SER GLN GLY CYS SER GLU GLN VAL LEU THR VAL LEU LYS          
SEQRES 255 A 4128  THR VAL SER LEU LEU ASP GLU ASN ASN VAL SER SER TYR          
SEQRES 256 A 4128  LEU SER LYS ASN ILE LEU ALA PHE ARG ASP GLN ASN ILE          
SEQRES 257 A 4128  LEU LEU GLY THR THR TYR ARG ILE ILE ALA ASN ALA LEU          
SEQRES 258 A 4128  SER SER GLU PRO ALA CYS LEU ALA GLU ILE GLU GLU ASP          
SEQRES 259 A 4128  LYS ALA ARG ARG ILE LEU GLU LEU SER GLY SER SER SER          
SEQRES 260 A 4128  GLU ASP SER GLU LYS VAL ILE ALA GLY LEU TYR GLN ARG          
SEQRES 261 A 4128  ALA PHE GLN HIS LEU SER GLU ALA VAL GLN ALA ALA GLU          
SEQRES 262 A 4128  GLU GLU ALA GLN PRO PRO SER TRP SER CYS GLY PRO ALA          
SEQRES 263 A 4128  ALA GLY VAL ILE ASP ALA TYR MSE THR LEU ALA ASP PHE          
SEQRES 264 A 4128  CYS ASP GLN GLN LEU ARG LYS GLU GLU GLU ASN ALA SER          
SEQRES 265 A 4128  VAL ILE ASP SER ALA GLU LEU GLN ALA TYR PRO ALA LEU          
SEQRES 266 A 4128  VAL VAL GLU LYS MSE LEU LYS ALA LEU LYS LEU ASN SER          
SEQRES 267 A 4128  ASN GLU ALA ARG LEU LYS PHE PRO ARG LEU LEU GLN ILE          
SEQRES 268 A 4128  ILE GLU ARG TYR PRO GLU GLU THR LEU SER LEU MSE THR          
SEQRES 269 A 4128  LYS GLU ILE SER SER VAL PRO CYS TRP GLN PHE ILE SER          
SEQRES 270 A 4128  TRP ILE SER HIS MSE VAL ALA LEU LEU ASP LYS ASP GLN          
SEQRES 271 A 4128  ALA VAL ALA VAL GLN HIS SER VAL GLU GLU ILE THR ASP          
SEQRES 272 A 4128  ASN TYR PRO GLN ALA ILE VAL TYR PRO PHE ILE ILE SER          
SEQRES 273 A 4128  SER GLU SER TYR SER PHE LYS ASP THR SER THR GLY HIS          
SEQRES 274 A 4128  LYS ASN LYS GLU PHE VAL ALA ARG ILE LYS SER LYS LEU          
SEQRES 275 A 4128  ASP GLN GLY GLY VAL ILE GLN ASP PHE ILE ASN ALA LEU          
SEQRES 276 A 4128  ASP GLN LEU SER ASN PRO GLU LEU LEU PHE LYS ASP TRP          
SEQRES 277 A 4128  SER ASN ASP VAL ARG ALA GLU LEU ALA LYS THR PRO VAL          
SEQRES 278 A 4128  ASN LYS LYS ASN ILE GLU LYS MSE TYR GLU ARG MSE TYR          
SEQRES 279 A 4128  ALA ALA LEU GLY ASP PRO LYS ALA PRO GLY LEU GLY ALA          
SEQRES 280 A 4128  PHE ARG ARG LYS PHE ILE GLN THR PHE GLY LYS GLU PHE          
SEQRES 281 A 4128  ASP LYS HIS PHE GLY LYS GLY GLY SER LYS LEU LEU ARG          
SEQRES 282 A 4128  MSE LYS LEU SER ASP PHE ASN ASP ILE THR ASN MSE LEU          
SEQRES 283 A 4128  LEU LEU LYS MSE ASN LYS ASP SER LYS PRO PRO GLY ASN          
SEQRES 284 A 4128  LEU LYS GLU CYS SER PRO TRP MSE SER ASP PHE LYS VAL          
SEQRES 285 A 4128  GLU PHE LEU ARG ASN GLU LEU GLU ILE PRO GLY GLN TYR          
SEQRES 286 A 4128  ASP GLY ARG GLY LYS PRO LEU PRO GLU TYR HIS VAL ARG          
SEQRES 287 A 4128  ILE ALA GLY PHE ASP GLU ARG VAL THR VAL MSE ALA SER          
SEQRES 288 A 4128  LEU ARG ARG PRO LYS ARG ILE ILE ILE ARG GLY HIS ASP          
SEQRES 289 A 4128  GLU ARG GLU HIS PRO PHE LEU VAL LYS GLY GLY GLU ASP          
SEQRES 290 A 4128  LEU ARG GLN ASP GLN ARG VAL GLU GLN LEU PHE GLN VAL          
SEQRES 291 A 4128  MSE ASN GLY ILE LEU ALA GLN ASP SER ALA CYS SER GLN          
SEQRES 292 A 4128  ARG ALA LEU GLN LEU ARG THR TYR SER VAL VAL PRO MSE          
SEQRES 293 A 4128  THR SER ARG LEU GLY LEU ILE GLU TRP LEU GLU ASN THR          
SEQRES 294 A 4128  VAL THR LEU LYS ASP LEU LEU LEU ASN THR MSE SER GLN          
SEQRES 295 A 4128  GLU GLU LYS ALA ALA TYR LEU SER ASP PRO ARG ALA PRO          
SEQRES 296 A 4128  PRO CYS GLU TYR LYS ASP TRP LEU THR LYS MSE SER GLY          
SEQRES 297 A 4128  LYS HIS ASP VAL GLY ALA TYR MSE LEU MSE TYR LYS GLY          
SEQRES 298 A 4128  ALA ASN ARG THR GLU THR VAL THR SER PHE ARG LYS ARG          
SEQRES 299 A 4128  GLU SER LYS VAL PRO ALA ASP LEU LEU LYS ARG ALA PHE          
SEQRES 300 A 4128  VAL ARG MSE SER THR SER PRO GLU ALA PHE LEU ALA LEU          
SEQRES 301 A 4128  ARG SER HIS PHE ALA SER SER HIS ALA LEU ILE CYS ILE          
SEQRES 302 A 4128  SER HIS TRP ILE LEU GLY ILE GLY ASP ARG HIS LEU ASN          
SEQRES 303 A 4128  ASN PHE MSE VAL ALA MSE GLU THR GLY GLY VAL ILE GLY          
SEQRES 304 A 4128  ILE ASP PHE GLY HIS ALA PHE GLY SER ALA THR GLN PHE          
SEQRES 305 A 4128  LEU PRO VAL PRO GLU LEU MSE PRO PHE ARG LEU THR ARG          
SEQRES 306 A 4128  GLN PHE ILE ASN LEU MSE LEU PRO MSE LYS GLU THR GLY          
SEQRES 307 A 4128  LEU MSE TYR SER ILE MSE VAL HIS ALA LEU ARG ALA PHE          
SEQRES 308 A 4128  ARG SER ASP PRO GLY LEU LEU THR ASN THR MSE ASP VAL          
SEQRES 309 A 4128  PHE VAL LYS GLU PRO SER PHE ASP TRP LYS ASN PHE GLU          
SEQRES 310 A 4128  GLN LYS MSE LEU LYS LYS GLY GLY SER TRP ILE GLN GLU          
SEQRES 311 A 4128  ILE ASN VAL ALA GLU LYS ASN TRP TYR PRO ARG GLN LYS          
SEQRES 312 A 4128  ILE CYS TYR ALA LYS ARG LYS LEU ALA GLY ALA ASN PRO          
SEQRES 313 A 4128  ALA VAL ILE THR CYS ASP GLU LEU LEU LEU GLY HIS GLU          
SEQRES 314 A 4128  LYS ALA PRO ALA PHE ARG ASP TYR VAL ALA VAL ALA ARG          
SEQRES 315 A 4128  GLY SER LYS ASP HIS ASN ILE ARG ALA GLN GLU PRO GLU          
SEQRES 316 A 4128  SER GLY LEU SER GLU GLU THR GLN VAL LYS CYS LEU MSE          
SEQRES 317 A 4128  ASP GLN ALA THR ASP PRO ASN ILE LEU GLY ARG THR TRP          
SEQRES 318 A 4128  GLU GLY TRP GLU PRO TRP MSE                                  
SEQRES   1 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   2 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   3 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   4 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   5 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   6 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   7 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   8 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   9 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  10 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  11 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  12 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  13 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  14 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  15 K  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK MSE UNK              
SEQRES   1 B 4128  MSE ALA GLY SER GLY ALA GLY VAL ARG CYS SER LEU LEU          
SEQRES   2 B 4128  ARG LEU GLN GLU THR LEU SER ALA ALA ASP ARG CYS GLY          
SEQRES   3 B 4128  ALA ALA LEU ALA GLY HIS GLN LEU ILE ARG GLY LEU GLY          
SEQRES   4 B 4128  GLN GLU CYS VAL LEU SER SER SER PRO ALA VAL LEU ALA          
SEQRES   5 B 4128  LEU GLN THR SER LEU VAL PHE SER ARG ASP PHE GLY LEU          
SEQRES   6 B 4128  LEU VAL PHE VAL ARG LYS SER LEU ASN SER ILE GLU PHE          
SEQRES   7 B 4128  ARG GLU CYS ARG GLU GLU ILE LEU LYS PHE LEU CYS ILE          
SEQRES   8 B 4128  PHE LEU GLU LYS MSE GLY GLN LYS ILE ALA PRO TYR SER          
SEQRES   9 B 4128  VAL GLU ILE LYS ASN THR CYS THR SER VAL TYR THR LYS          
SEQRES  10 B 4128  ASP ARG ALA ALA LYS CYS LYS ILE PRO ALA LEU ASP LEU          
SEQRES  11 B 4128  LEU ILE LYS LEU LEU GLN THR PHE ARG SER SER ARG LEU          
SEQRES  12 B 4128  MSE ASP GLU PHE LYS ILE GLY GLU LEU PHE SER LYS PHE          
SEQRES  13 B 4128  TYR GLY GLU LEU ALA LEU LYS LYS LYS ILE PRO ASP THR          
SEQRES  14 B 4128  VAL LEU GLU LYS VAL TYR GLU LEU LEU GLY LEU LEU GLY          
SEQRES  15 B 4128  GLU VAL HIS PRO SER GLU MSE ILE ASN ASN ALA GLU ASN          
SEQRES  16 B 4128  LEU PHE ARG ALA PHE LEU GLY GLU LEU LYS THR GLN MSE          
SEQRES  17 B 4128  THR SER ALA VAL ARG GLU PRO LYS LEU PRO VAL LEU ALA          
SEQRES  18 B 4128  GLY CYS LEU LYS GLY LEU SER SER LEU LEU CYS ASN PHE          
SEQRES  19 B 4128  THR LYS SER MSE GLU GLU ASP PRO GLN THR SER ARG GLU          
SEQRES  20 B 4128  ILE PHE ASN PHE VAL LEU LYS ALA ILE ARG PRO GLN ILE          
SEQRES  21 B 4128  ASP LEU LYS ARG TYR ALA VAL PRO SER ALA GLY LEU ARG          
SEQRES  22 B 4128  LEU PHE ALA LEU HIS ALA SER GLN PHE SER THR CYS LEU          
SEQRES  23 B 4128  LEU ASP ASN TYR VAL SER LEU PHE GLU VAL LEU LEU LYS          
SEQRES  24 B 4128  TRP CYS ALA HIS THR ASN VAL GLU LEU LYS LYS ALA ALA          
SEQRES  25 B 4128  LEU SER ALA LEU GLU SER PHE LEU LYS GLN VAL SER ASN          
SEQRES  26 B 4128  MSE VAL ALA LYS ASN ALA GLU MSE HIS LYS ASN LYS LEU          
SEQRES  27 B 4128  GLN TYR PHE MSE GLU GLN PHE TYR GLY ILE ILE ARG ASN          
SEQRES  28 B 4128  VAL ASP SER ASN ASN LYS GLU LEU SER ILE ALA ILE ARG          
SEQRES  29 B 4128  GLY TYR GLY LEU PHE ALA GLY PRO CYS LYS VAL ILE ASN          
SEQRES  30 B 4128  ALA LYS ASP VAL ASP PHE MSE TYR VAL GLU LEU ILE GLN          
SEQRES  31 B 4128  ARG CYS LYS GLN MSE PHE LEU THR GLN THR ASP THR GLY          
SEQRES  32 B 4128  ASP ASP ARG VAL TYR GLN MSE PRO SER PHE LEU GLN SER          
SEQRES  33 B 4128  VAL ALA SER VAL LEU LEU TYR LEU ASP THR VAL PRO GLU          
SEQRES  34 B 4128  VAL TYR THR PRO VAL LEU GLU HIS LEU VAL VAL MSE GLN          
SEQRES  35 B 4128  ILE ASP SER PHE PRO GLN TYR SER PRO LYS MSE GLN LEU          
SEQRES  36 B 4128  VAL CYS CYS ARG ALA ILE VAL LYS VAL PHE LEU ALA LEU          
SEQRES  37 B 4128  ALA ALA LYS GLY PRO VAL LEU ARG ASN CYS ILE SER THR          
SEQRES  38 B 4128  VAL VAL HIS GLN GLY LEU ILE ARG ILE CYS SER LYS PRO          
SEQRES  39 B 4128  VAL VAL LEU PRO LYS GLY PRO GLU SER GLU SER GLU ASP          
SEQRES  40 B 4128  HIS ARG ALA SER GLY GLU VAL ARG THR GLY LYS TRP LYS          
SEQRES  41 B 4128  VAL PRO THR TYR LYS ASP TYR VAL ASP LEU PHE ARG HIS          
SEQRES  42 B 4128  LEU LEU SER SER ASP GLN MSE MSE ASP SER ILE LEU ALA          
SEQRES  43 B 4128  ASP GLU ALA PHE PHE SER VAL ASN SER SER SER GLU SER          
SEQRES  44 B 4128  LEU ASN HIS LEU LEU TYR ASP GLU PHE VAL LYS SER VAL          
SEQRES  45 B 4128  LEU LYS ILE VAL GLU LYS LEU ASP LEU THR LEU GLU ILE          
SEQRES  46 B 4128  GLN THR VAL GLY GLU GLN GLU ASN GLY ASP GLU ALA PRO          
SEQRES  47 B 4128  GLY VAL TRP MSE ILE PRO THR SER ASP PRO ALA ALA ASN          
SEQRES  48 B 4128  LEU HIS PRO ALA LYS PRO LYS ASP PHE SER ALA PHE ILE          
SEQRES  49 B 4128  ASN LEU VAL GLU PHE CYS ARG GLU ILE LEU PRO GLU LYS          
SEQRES  50 B 4128  GLN ALA GLU PHE PHE GLU PRO TRP VAL TYR SER PHE SER          
SEQRES  51 B 4128  TYR GLU LEU ILE LEU GLN SER THR ARG LEU PRO LEU ILE          
SEQRES  52 B 4128  SER GLY PHE TYR LYS LEU LEU SER ILE THR VAL ARG ASN          
SEQRES  53 B 4128  ALA LYS LYS ILE LYS TYR PHE GLU GLY VAL SER PRO LYS          
SEQRES  54 B 4128  SER LEU LYS HIS SER PRO GLU ASP PRO GLU LYS TYR SER          
SEQRES  55 B 4128  CYS PHE ALA LEU PHE VAL LYS PHE GLY LYS GLU VAL ALA          
SEQRES  56 B 4128  VAL LYS MSE LYS GLN TYR LYS ASP GLU LEU LEU ALA SER          
SEQRES  57 B 4128  CYS LEU THR PHE LEU LEU SER LEU PRO HIS ASN ILE ILE          
SEQRES  58 B 4128  GLU LEU ASP VAL ARG ALA TYR VAL PRO ALA LEU GLN MSE          
SEQRES  59 B 4128  ALA PHE LYS LEU GLY LEU SER TYR THR PRO LEU ALA GLU          
SEQRES  60 B 4128  VAL GLY LEU ASN ALA LEU GLU GLU TRP SER ILE TYR ILE          
SEQRES  61 B 4128  ASP ARG HIS VAL MSE GLN PRO TYR TYR LYS ASP ILE LEU          
SEQRES  62 B 4128  PRO CYS LEU ASP GLY TYR LEU LYS THR SER ALA LEU SER          
SEQRES  63 B 4128  ASP GLU THR LYS ASN ASN TRP GLU VAL SER ALA LEU SER          
SEQRES  64 B 4128  ARG ALA ALA GLN LYS GLY PHE ASN LYS VAL VAL LEU LYS          
SEQRES  65 B 4128  HIS LEU LYS LYS THR LYS ASN LEU SER SER ASN GLU ALA          
SEQRES  66 B 4128  ILE SER LEU GLU GLU ILE ARG ILE ARG VAL VAL GLN MSE          
SEQRES  67 B 4128  LEU GLY SER LEU GLY GLY GLN ILE ASN LYS ASN LEU LEU          
SEQRES  68 B 4128  THR VAL THR SER SER ASP GLU MSE MSE LYS SER TYR VAL          
SEQRES  69 B 4128  ALA TRP ASP ARG GLU LYS ARG LEU SER PHE ALA VAL PRO          
SEQRES  70 B 4128  PHE ARG GLU MSE LYS PRO VAL ILE PHE LEU ASP VAL PHE          
SEQRES  71 B 4128  LEU PRO ARG VAL THR GLU LEU ALA LEU THR ALA SER ASP          
SEQRES  72 B 4128  ARG GLN THR LYS VAL ALA ALA CYS GLU LEU LEU HIS SER          
SEQRES  73 B 4128  MSE VAL MSE PHE MSE LEU GLY LYS ALA THR GLN MSE PRO          
SEQRES  74 B 4128  GLU GLY GLY GLN GLY ALA PRO PRO MSE TYR GLN LEU TYR          
SEQRES  75 B 4128  LYS ARG THR PHE PRO VAL LEU LEU ARG LEU ALA CYS ASP          
SEQRES  76 B 4128  VAL ASP GLN VAL THR ARG GLN LEU TYR GLU PRO LEU VAL          
SEQRES  77 B 4128  MSE GLN LEU ILE HIS TRP PHE THR ASN ASN LYS LYS PHE          
SEQRES  78 B 4128  GLU SER GLN ASP THR VAL ALA LEU LEU GLU ALA ILE LEU          
SEQRES  79 B 4128  ASP GLY ILE VAL ASP PRO VAL ASP SER THR LEU ARG ASP          
SEQRES  80 B 4128  PHE CYS GLY ARG CYS ILE ARG GLU PHE LEU LYS TRP SER          
SEQRES  81 B 4128  ILE LYS GLN ILE THR PRO GLN GLN GLN GLU LYS SER PRO          
SEQRES  82 B 4128  VAL ASN THR LYS SER LEU PHE LYS ARG LEU TYR SER LEU          
SEQRES  83 B 4128  ALA LEU HIS PRO ASN ALA PHE LYS ARG LEU GLY ALA SER          
SEQRES  84 B 4128  LEU ALA PHE ASN ASN ILE TYR ARG GLU PHE ARG GLU GLU          
SEQRES  85 B 4128  GLU SER LEU VAL GLU GLN PHE VAL PHE GLU ALA LEU VAL          
SEQRES  86 B 4128  ILE TYR MSE GLU SER LEU ALA LEU ALA HIS ALA ASP GLU          
SEQRES  87 B 4128  LYS SER LEU GLY THR ILE GLN GLN CYS CYS ASP ALA ILE          
SEQRES  88 B 4128  ASP HIS LEU CYS ARG ILE ILE GLU LYS LYS HIS VAL SER          
SEQRES  89 B 4128  LEU ASN LYS ALA LYS LYS ARG ARG LEU PRO ARG GLY PHE          
SEQRES  90 B 4128  PRO PRO SER ALA SER LEU CYS LEU LEU ASP LEU VAL LYS          
SEQRES  91 B 4128  TRP LEU LEU ALA HIS CYS GLY ARG PRO GLN THR GLU CYS          
SEQRES  92 B 4128  ARG HIS LYS SER ILE GLU LEU PHE TYR LYS PHE VAL PRO          
SEQRES  93 B 4128  LEU LEU PRO GLY ASN ARG SER PRO ASN LEU TRP LEU LYS          
SEQRES  94 B 4128  ASP VAL LEU LYS GLU GLU GLY VAL SER PHE LEU ILE ASN          
SEQRES  95 B 4128  THR PHE GLU GLY GLY GLY CYS GLY GLN PRO SER GLY ILE          
SEQRES  96 B 4128  LEU ALA GLN PRO THR LEU LEU TYR LEU ARG GLY PRO PHE          
SEQRES  97 B 4128  SER LEU GLN ALA THR LEU CYS TRP LEU ASP LEU LEU LEU          
SEQRES  98 B 4128  ALA ALA LEU GLU CYS TYR ASN THR PHE ILE GLY GLU ARG          
SEQRES  99 B 4128  THR VAL GLY ALA LEU GLN VAL LEU GLY THR GLU ALA GLN          
SEQRES 100 B 4128  SER SER LEU LEU LYS ALA VAL ALA PHE PHE LEU GLU SER          
SEQRES 101 B 4128  ILE ALA MSE HIS ASP ILE ILE ALA ALA GLU LYS CYS PHE          
SEQRES 102 B 4128  GLY THR GLY ALA ALA GLY ASN ARG THR SER PRO GLN GLU          
SEQRES 103 B 4128  GLY GLU ARG TYR ASN TYR SER LYS CYS THR VAL VAL VAL          
SEQRES 104 B 4128  ARG ILE MSE GLU PHE THR THR THR LEU LEU ASN THR SER          
SEQRES 105 B 4128  PRO GLU GLY TRP LYS LEU LEU LYS LYS ASP LEU CYS ASN          
SEQRES 106 B 4128  THR HIS LEU MSE ARG VAL LEU VAL GLN THR LEU CYS GLU          
SEQRES 107 B 4128  PRO ALA SER ILE GLY PHE ASN ILE GLY ASP VAL GLN VAL          
SEQRES 108 B 4128  MSE ALA HIS LEU PRO ASP VAL CYS VAL ASN LEU MSE LYS          
SEQRES 109 B 4128  ALA LEU LYS MSE SER PRO TYR LYS ASP ILE LEU GLU THR          
SEQRES 110 B 4128  HIS LEU ARG GLU LYS ILE THR ALA GLN SER ILE GLU GLU          
SEQRES 111 B 4128  LEU CYS ALA VAL ASN LEU TYR GLY PRO ASP ALA GLN VAL          
SEQRES 112 B 4128  ASP ARG SER ARG LEU ALA ALA VAL VAL SER ALA CYS LYS          
SEQRES 113 B 4128  GLN LEU HIS ARG ALA GLY LEU LEU HIS ASN ILE LEU PRO          
SEQRES 114 B 4128  SER GLN SER THR ASP LEU HIS HIS SER VAL GLY THR GLU          
SEQRES 115 B 4128  LEU LEU SER LEU VAL TYR LYS GLY ILE ALA PRO GLY ASP          
SEQRES 116 B 4128  GLU ARG GLN CYS LEU PRO SER LEU ASP LEU SER CYS LYS          
SEQRES 117 B 4128  GLN LEU ALA SER GLY LEU LEU GLU LEU ALA PHE ALA PHE          
SEQRES 118 B 4128  GLY GLY LEU CYS GLU ARG LEU VAL SER LEU LEU LEU ASN          
SEQRES 119 B 4128  PRO ALA VAL LEU SER THR ALA SER LEU GLY SER SER GLN          
SEQRES 120 B 4128  GLY SER VAL ILE HIS PHE SER HIS GLY GLU TYR PHE TYR          
SEQRES 121 B 4128  SER LEU PHE SER GLU THR ILE ASN THR GLU LEU LEU LYS          
SEQRES 122 B 4128  ASN LEU ASP LEU ALA VAL LEU GLU LEU MSE GLN SER SER          
SEQRES 123 B 4128  VAL ASP ASN THR LYS MSE VAL SER ALA VAL LEU ASN GLY          
SEQRES 124 B 4128  MSE LEU ASP GLN SER PHE ARG GLU ARG ALA ASN GLN LYS          
SEQRES 125 B 4128  HIS GLN GLY LEU LYS LEU ALA THR THR ILE LEU GLN HIS          
SEQRES 126 B 4128  TRP LYS LYS CYS ASP SER TRP TRP ALA LYS ASP SER PRO          
SEQRES 127 B 4128  LEU GLU THR LYS MSE ALA VAL LEU ALA LEU LEU ALA LYS          
SEQRES 128 B 4128  ILE LEU GLN ILE ASP SER SER VAL SER PHE ASN THR SER          
SEQRES 129 B 4128  HIS GLY SER PHE PRO GLU VAL PHE THR THR TYR ILE SER          
SEQRES 130 B 4128  LEU LEU ALA ASP THR LYS LEU ASP LEU HIS LEU LYS GLY          
SEQRES 131 B 4128  GLN ALA VAL THR LEU LEU PRO PHE PHE THR SER LEU THR          
SEQRES 132 B 4128  GLY GLY SER LEU GLU GLU LEU ARG ARG VAL LEU GLU GLN          
SEQRES 133 B 4128  LEU ILE VAL ALA HIS PHE PRO MSE GLN SER ARG GLU PHE          
SEQRES 134 B 4128  PRO PRO GLY THR PRO ARG PHE ASN ASN TYR VAL ASP CYS          
SEQRES 135 B 4128  MSE LYS LYS PHE LEU ASP ALA LEU GLU LEU SER GLN SER          
SEQRES 136 B 4128  PRO MSE LEU LEU GLU LEU MSE THR GLU VAL LEU CYS ARG          
SEQRES 137 B 4128  GLU GLN GLN HIS VAL MSE GLU GLU LEU PHE GLN SER SER          
SEQRES 138 B 4128  PHE ARG ARG ILE ALA ARG ARG GLY SER CYS VAL THR GLN          
SEQRES 139 B 4128  VAL GLY LEU LEU GLU SER VAL TYR GLU MSE PHE ARG LYS          
SEQRES 140 B 4128  ASP ASP PRO ARG LEU SER PHE THR ARG GLN SER PHE VAL          
SEQRES 141 B 4128  ASP ARG SER LEU LEU THR LEU LEU TRP HIS CYS SER LEU          
SEQRES 142 B 4128  ASP ALA LEU ARG GLU PHE PHE SER THR ILE VAL VAL ASP          
SEQRES 143 B 4128  ALA ILE ASP VAL LEU LYS SER ARG PHE THR LYS LEU ASN          
SEQRES 144 B 4128  GLU SER THR PHE ASP THR GLN ILE THR LYS LYS MSE GLY          
SEQRES 145 B 4128  TYR TYR LYS ILE LEU ASP VAL MSE TYR SER ARG LEU PRO          
SEQRES 146 B 4128  LYS ASP ASP VAL HIS ALA LYS GLU SER LYS ILE ASN GLN          
SEQRES 147 B 4128  VAL PHE HIS GLY SER CYS ILE THR GLU GLY ASN GLU LEU          
SEQRES 148 B 4128  THR LYS THR LEU ILE LYS LEU CYS TYR ASP ALA PHE THR          
SEQRES 149 B 4128  GLU ASN MSE ALA GLY GLU ASN GLN LEU LEU GLU ARG ARG          
SEQRES 150 B 4128  ARG LEU TYR HIS CYS ALA ALA TYR ASN CYS ALA ILE SER          
SEQRES 151 B 4128  VAL ILE CYS CYS VAL PHE ASN GLU LEU LYS PHE TYR GLN          
SEQRES 152 B 4128  GLY PHE LEU PHE SER GLU LYS PRO GLU LYS ASN LEU LEU          
SEQRES 153 B 4128  ILE PHE GLU ASN LEU ILE ASP LEU LYS ARG ARG TYR ASN          
SEQRES 154 B 4128  PHE PRO VAL GLU VAL GLU VAL PRO MSE GLU ARG LYS LYS          
SEQRES 155 B 4128  LYS TYR ILE GLU ILE ARG LYS GLU ALA ARG GLU ALA ALA          
SEQRES 156 B 4128  ASN GLY ASP SER ASP GLY PRO SER TYR MSE SER SER LEU          
SEQRES 157 B 4128  SER TYR LEU ALA ASP SER THR LEU SER GLU GLU MSE SER          
SEQRES 158 B 4128  GLN PHE ASP PHE SER THR GLY VAL GLN SER TYR SER TYR          
SEQRES 159 B 4128  SER SER GLN ASP PRO ARG PRO ALA THR GLY ARG PHE ARG          
SEQRES 160 B 4128  ARG ARG GLU GLN ARG ASP PRO THR VAL HIS ASP ASP VAL          
SEQRES 161 B 4128  LEU GLU LEU GLU MSE ASP GLU LEU ASN ARG HIS GLU CYS          
SEQRES 162 B 4128  MSE ALA PRO LEU THR ALA LEU VAL LYS HIS MSE HIS ARG          
SEQRES 163 B 4128  SER LEU GLY PRO PRO GLN GLY GLU GLU ASP SER VAL PRO          
SEQRES 164 B 4128  ARG ASP LEU PRO SER TRP MSE LYS PHE LEU HIS GLY LYS          
SEQRES 165 B 4128  LEU GLY ASN PRO ILE VAL PRO LEU ASN ILE ARG LEU PHE          
SEQRES 166 B 4128  LEU ALA LYS LEU VAL ILE ASN THR GLU GLU VAL PHE ARG          
SEQRES 167 B 4128  PRO TYR ALA LYS HIS TRP LEU SER PRO LEU LEU GLN LEU          
SEQRES 168 B 4128  ALA ALA SER GLU ASN ASN GLY GLY GLU GLY ILE HIS TYR          
SEQRES 169 B 4128  MSE VAL VAL GLU ILE VAL ALA THR ILE LEU SER TRP THR          
SEQRES 170 B 4128  GLY LEU ALA THR PRO THR GLY VAL PRO LYS ASP GLU VAL          
SEQRES 171 B 4128  LEU ALA ASN ARG LEU LEU ASN PHE LEU MSE LYS HIS VAL          
SEQRES 172 B 4128  PHE HIS PRO LYS ARG ALA VAL PHE ARG HIS ASN LEU GLU          
SEQRES 173 B 4128  ILE ILE LYS THR LEU VAL GLU CYS TRP LYS ASP CYS LEU          
SEQRES 174 B 4128  SER ILE PRO TYR ARG LEU ILE PHE GLU LYS PHE SER GLY          
SEQRES 175 B 4128  LYS ASP PRO ASN SER LYS ASP ASN SER VAL GLY ILE GLN          
SEQRES 176 B 4128  LEU LEU GLY ILE VAL MSE ALA ASN ASP LEU PRO PRO TYR          
SEQRES 177 B 4128  ASP PRO GLN CYS GLY ILE GLN SER SER GLU TYR PHE GLN          
SEQRES 178 B 4128  ALA LEU VAL ASN ASN MSE SER PHE VAL ARG TYR LYS GLU          
SEQRES 179 B 4128  VAL TYR ALA ALA ALA ALA GLU VAL LEU GLY LEU ILE LEU          
SEQRES 180 B 4128  ARG TYR VAL MSE GLU ARG LYS ASN ILE LEU GLU GLU SER          
SEQRES 181 B 4128  LEU CYS GLU LEU VAL ALA LYS GLN LEU LYS GLN HIS GLN          
SEQRES 182 B 4128  ASN THR MSE GLU ASP LYS PHE ILE VAL CYS LEU ASN LYS          
SEQRES 183 B 4128  VAL THR LYS SER PHE PRO PRO LEU ALA ASP ARG PHE MSE          
SEQRES 184 B 4128  ASN ALA VAL PHE PHE LEU LEU PRO LYS PHE HIS GLY VAL          
SEQRES 185 B 4128  LEU LYS THR LEU CYS LEU GLU VAL VAL LEU CYS ARG VAL          
SEQRES 186 B 4128  GLU GLY MSE THR GLU LEU TYR PHE GLN LEU LYS SER LYS          
SEQRES 187 B 4128  ASP PHE VAL GLN VAL MSE ARG HIS ARG ASP ASP GLU ARG          
SEQRES 188 B 4128  GLN LYS VAL CYS LEU ASP ILE ILE TYR LYS MSE MSE PRO          
SEQRES 189 B 4128  LYS LEU LYS PRO VAL GLU LEU ARG GLU LEU LEU ASN PRO          
SEQRES 190 B 4128  VAL VAL GLU PHE VAL SER HIS PRO SER THR THR CYS ARG          
SEQRES 191 B 4128  GLU GLN MSE TYR ASN ILE LEU MSE TRP ILE HIS ASP ASN          
SEQRES 192 B 4128  TYR ARG ASP PRO GLU SER GLU THR ASP ASN ASP SER GLN          
SEQRES 193 B 4128  GLU ILE PHE LYS LEU ALA LYS ASP VAL LEU ILE GLN GLY          
SEQRES 194 B 4128  LEU ILE ASP GLU ASN PRO GLY LEU GLN LEU ILE ILE ARG          
SEQRES 195 B 4128  ASN PHE TRP SER HIS GLU THR ARG LEU PRO SER ASN THR          
SEQRES 196 B 4128  LEU ASP ARG LEU LEU ALA LEU ASN SER LEU TYR SER PRO          
SEQRES 197 B 4128  LYS ILE GLU VAL HIS PHE LEU SER LEU ALA THR ASN PHE          
SEQRES 198 B 4128  LEU LEU GLU MSE THR SER MSE SER PRO ASP TYR PRO ASN          
SEQRES 199 B 4128  PRO MSE UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 200 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 201 B 4128  UNK UNK UNK UNK MSE UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 202 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 203 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 204 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 205 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 206 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 207 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 208 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 209 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 210 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 211 B 4128  UNK UNK MSE UNK UNK UNK UNK UNK UNK UNK UNK MSE UNK          
SEQRES 212 B 4128  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES 213 B 4128  UNK UNK UNK UNK UNK UNK MSE UNK UNK UNK UNK UNK UNK          
SEQRES 214 B 4128  UNK UNK UNK UNK SER TYR ARG HIS GLY ASP LEU PRO ASP          
SEQRES 215 B 4128  ILE GLN ILE LYS HIS SER SER LEU ILE THR PRO LEU GLN          
SEQRES 216 B 4128  ALA VAL ALA GLN ARG ASP PRO ILE ILE ALA LYS GLN LEU          
SEQRES 217 B 4128  PHE SER SER LEU PHE SER GLY ILE LEU LYS GLU MSE ASP          
SEQRES 218 B 4128  LYS PHE LYS THR LEU SER GLU LYS ASN ASN ILE THR GLN          
SEQRES 219 B 4128  LYS LEU LEU GLN ASP PHE ASN ARG PHE LEU ASN THR THR          
SEQRES 220 B 4128  PHE SER PHE PHE PRO PRO PHE VAL SER CYS ILE GLN ASP          
SEQRES 221 B 4128  ILE SER CYS GLN HIS ALA ALA LEU LEU SER LEU ASP PRO          
SEQRES 222 B 4128  ALA ALA VAL SER ALA GLY CYS LEU ALA SER LEU GLN GLN          
SEQRES 223 B 4128  PRO VAL GLY ILE ARG LEU LEU GLU GLU ALA LEU LEU ARG          
SEQRES 224 B 4128  LEU LEU PRO ALA GLU LEU PRO ALA LYS ARG VAL ARG GLY          
SEQRES 225 B 4128  LYS ALA ARG LEU PRO PRO ASP VAL LEU ARG TRP VAL GLU          
SEQRES 226 B 4128  LEU ALA LYS LEU TYR ARG SER ILE GLY GLU TYR ASP VAL          
SEQRES 227 B 4128  LEU ARG GLY ILE PHE THR SER GLU ILE GLY THR LYS GLN          
SEQRES 228 B 4128  ILE THR GLN SER ALA LEU LEU ALA GLU ALA ARG SER ASP          
SEQRES 229 B 4128  TYR SER GLU ALA ALA LYS GLN TYR ASP GLU ALA LEU ASN          
SEQRES 230 B 4128  LYS GLN ASP TRP VAL ASP GLY GLU PRO THR GLU ALA GLU          
SEQRES 231 B 4128  LYS ASP PHE TRP GLU LEU ALA SER LEU ASP CYS TYR ASN          
SEQRES 232 B 4128  HIS LEU ALA GLU TRP LYS SER LEU GLU TYR CYS SER THR          
SEQRES 233 B 4128  ALA SER ILE ASP SER GLU ASN PRO PRO ASP LEU ASN LYS          
SEQRES 234 B 4128  ILE TRP SER GLU PRO PHE TYR GLN GLU THR TYR LEU PRO          
SEQRES 235 B 4128  TYR MSE ILE ARG SER LYS LEU LYS LEU LEU LEU GLN GLY          
SEQRES 236 B 4128  GLU ALA ASP GLN SER LEU LEU THR PHE ILE ASP LYS ALA          
SEQRES 237 B 4128  MSE HIS GLY GLU LEU GLN LYS ALA ILE LEU GLU LEU HIS          
SEQRES 238 B 4128  TYR SER GLN GLU LEU SER LEU LEU TYR LEU LEU GLN ASP          
SEQRES 239 B 4128  ASP VAL ASP ARG ALA LYS TYR TYR ILE GLN ASN GLY ILE          
SEQRES 240 B 4128  GLN SER PHE MSE GLN ASN TYR SER SER ILE ASP VAL LEU          
SEQRES 241 B 4128  LEU HIS GLN SER ARG LEU THR LYS LEU GLN SER VAL GLN          
SEQRES 242 B 4128  ALA LEU THR GLU ILE GLN GLU PHE ILE SER PHE ILE SER          
SEQRES 243 B 4128  LYS GLN GLY ASN LEU SER SER GLN VAL PRO LEU LYS ARG          
SEQRES 244 B 4128  LEU LEU ASN THR TRP THR ASN ARG TYR PRO ASP ALA LYS          
SEQRES 245 B 4128  MSE ASP PRO MSE ASN ILE TRP ASP ASP ILE ILE THR ASN          
SEQRES 246 B 4128  ARG CYS PHE PHE LEU SER LYS ILE GLU GLU LYS LEU THR          
SEQRES 247 B 4128  PRO LEU PRO GLU ASP ASN SER MSE ASN VAL ASP GLN ASP          
SEQRES 248 B 4128  GLY ASP PRO SER ASP ARG MSE GLU VAL GLN GLU GLN GLU          
SEQRES 249 B 4128  GLU ASP ILE SER SER LEU ILE ARG SER CYS LYS PHE SER          
SEQRES 250 B 4128  MSE LYS MSE LYS MSE ILE ASP SER ALA ARG LYS GLN ASN          
SEQRES 251 B 4128  ASN PHE SER LEU ALA MSE LYS LEU LEU LYS GLU LEU HIS          
SEQRES 252 B 4128  LYS GLU SER LYS THR ARG ASP ASP TRP LEU VAL SER TRP          
SEQRES 253 B 4128  VAL GLN SER TYR CYS ARG LEU SER HIS CYS ARG SER ARG          
SEQRES 254 B 4128  SER GLN GLY CYS SER GLU GLN VAL LEU THR VAL LEU LYS          
SEQRES 255 B 4128  THR VAL SER LEU LEU ASP GLU ASN ASN VAL SER SER TYR          
SEQRES 256 B 4128  LEU SER LYS ASN ILE LEU ALA PHE ARG ASP GLN ASN ILE          
SEQRES 257 B 4128  LEU LEU GLY THR THR TYR ARG ILE ILE ALA ASN ALA LEU          
SEQRES 258 B 4128  SER SER GLU PRO ALA CYS LEU ALA GLU ILE GLU GLU ASP          
SEQRES 259 B 4128  LYS ALA ARG ARG ILE LEU GLU LEU SER GLY SER SER SER          
SEQRES 260 B 4128  GLU ASP SER GLU LYS VAL ILE ALA GLY LEU TYR GLN ARG          
SEQRES 261 B 4128  ALA PHE GLN HIS LEU SER GLU ALA VAL GLN ALA ALA GLU          
SEQRES 262 B 4128  GLU GLU ALA GLN PRO PRO SER TRP SER CYS GLY PRO ALA          
SEQRES 263 B 4128  ALA GLY VAL ILE ASP ALA TYR MSE THR LEU ALA ASP PHE          
SEQRES 264 B 4128  CYS ASP GLN GLN LEU ARG LYS GLU GLU GLU ASN ALA SER          
SEQRES 265 B 4128  VAL ILE ASP SER ALA GLU LEU GLN ALA TYR PRO ALA LEU          
SEQRES 266 B 4128  VAL VAL GLU LYS MSE LEU LYS ALA LEU LYS LEU ASN SER          
SEQRES 267 B 4128  ASN GLU ALA ARG LEU LYS PHE PRO ARG LEU LEU GLN ILE          
SEQRES 268 B 4128  ILE GLU ARG TYR PRO GLU GLU THR LEU SER LEU MSE THR          
SEQRES 269 B 4128  LYS GLU ILE SER SER VAL PRO CYS TRP GLN PHE ILE SER          
SEQRES 270 B 4128  TRP ILE SER HIS MSE VAL ALA LEU LEU ASP LYS ASP GLN          
SEQRES 271 B 4128  ALA VAL ALA VAL GLN HIS SER VAL GLU GLU ILE THR ASP          
SEQRES 272 B 4128  ASN TYR PRO GLN ALA ILE VAL TYR PRO PHE ILE ILE SER          
SEQRES 273 B 4128  SER GLU SER TYR SER PHE LYS ASP THR SER THR GLY HIS          
SEQRES 274 B 4128  LYS ASN LYS GLU PHE VAL ALA ARG ILE LYS SER LYS LEU          
SEQRES 275 B 4128  ASP GLN GLY GLY VAL ILE GLN ASP PHE ILE ASN ALA LEU          
SEQRES 276 B 4128  ASP GLN LEU SER ASN PRO GLU LEU LEU PHE LYS ASP TRP          
SEQRES 277 B 4128  SER ASN ASP VAL ARG ALA GLU LEU ALA LYS THR PRO VAL          
SEQRES 278 B 4128  ASN LYS LYS ASN ILE GLU LYS MSE TYR GLU ARG MSE TYR          
SEQRES 279 B 4128  ALA ALA LEU GLY ASP PRO LYS ALA PRO GLY LEU GLY ALA          
SEQRES 280 B 4128  PHE ARG ARG LYS PHE ILE GLN THR PHE GLY LYS GLU PHE          
SEQRES 281 B 4128  ASP LYS HIS PHE GLY LYS GLY GLY SER LYS LEU LEU ARG          
SEQRES 282 B 4128  MSE LYS LEU SER ASP PHE ASN ASP ILE THR ASN MSE LEU          
SEQRES 283 B 4128  LEU LEU LYS MSE ASN LYS ASP SER LYS PRO PRO GLY ASN          
SEQRES 284 B 4128  LEU LYS GLU CYS SER PRO TRP MSE SER ASP PHE LYS VAL          
SEQRES 285 B 4128  GLU PHE LEU ARG ASN GLU LEU GLU ILE PRO GLY GLN TYR          
SEQRES 286 B 4128  ASP GLY ARG GLY LYS PRO LEU PRO GLU TYR HIS VAL ARG          
SEQRES 287 B 4128  ILE ALA GLY PHE ASP GLU ARG VAL THR VAL MSE ALA SER          
SEQRES 288 B 4128  LEU ARG ARG PRO LYS ARG ILE ILE ILE ARG GLY HIS ASP          
SEQRES 289 B 4128  GLU ARG GLU HIS PRO PHE LEU VAL LYS GLY GLY GLU ASP          
SEQRES 290 B 4128  LEU ARG GLN ASP GLN ARG VAL GLU GLN LEU PHE GLN VAL          
SEQRES 291 B 4128  MSE ASN GLY ILE LEU ALA GLN ASP SER ALA CYS SER GLN          
SEQRES 292 B 4128  ARG ALA LEU GLN LEU ARG THR TYR SER VAL VAL PRO MSE          
SEQRES 293 B 4128  THR SER ARG LEU GLY LEU ILE GLU TRP LEU GLU ASN THR          
SEQRES 294 B 4128  VAL THR LEU LYS ASP LEU LEU LEU ASN THR MSE SER GLN          
SEQRES 295 B 4128  GLU GLU LYS ALA ALA TYR LEU SER ASP PRO ARG ALA PRO          
SEQRES 296 B 4128  PRO CYS GLU TYR LYS ASP TRP LEU THR LYS MSE SER GLY          
SEQRES 297 B 4128  LYS HIS ASP VAL GLY ALA TYR MSE LEU MSE TYR LYS GLY          
SEQRES 298 B 4128  ALA ASN ARG THR GLU THR VAL THR SER PHE ARG LYS ARG          
SEQRES 299 B 4128  GLU SER LYS VAL PRO ALA ASP LEU LEU LYS ARG ALA PHE          
SEQRES 300 B 4128  VAL ARG MSE SER THR SER PRO GLU ALA PHE LEU ALA LEU          
SEQRES 301 B 4128  ARG SER HIS PHE ALA SER SER HIS ALA LEU ILE CYS ILE          
SEQRES 302 B 4128  SER HIS TRP ILE LEU GLY ILE GLY ASP ARG HIS LEU ASN          
SEQRES 303 B 4128  ASN PHE MSE VAL ALA MSE GLU THR GLY GLY VAL ILE GLY          
SEQRES 304 B 4128  ILE ASP PHE GLY HIS ALA PHE GLY SER ALA THR GLN PHE          
SEQRES 305 B 4128  LEU PRO VAL PRO GLU LEU MSE PRO PHE ARG LEU THR ARG          
SEQRES 306 B 4128  GLN PHE ILE ASN LEU MSE LEU PRO MSE LYS GLU THR GLY          
SEQRES 307 B 4128  LEU MSE TYR SER ILE MSE VAL HIS ALA LEU ARG ALA PHE          
SEQRES 308 B 4128  ARG SER ASP PRO GLY LEU LEU THR ASN THR MSE ASP VAL          
SEQRES 309 B 4128  PHE VAL LYS GLU PRO SER PHE ASP TRP LYS ASN PHE GLU          
SEQRES 310 B 4128  GLN LYS MSE LEU LYS LYS GLY GLY SER TRP ILE GLN GLU          
SEQRES 311 B 4128  ILE ASN VAL ALA GLU LYS ASN TRP TYR PRO ARG GLN LYS          
SEQRES 312 B 4128  ILE CYS TYR ALA LYS ARG LYS LEU ALA GLY ALA ASN PRO          
SEQRES 313 B 4128  ALA VAL ILE THR CYS ASP GLU LEU LEU LEU GLY HIS GLU          
SEQRES 314 B 4128  LYS ALA PRO ALA PHE ARG ASP TYR VAL ALA VAL ALA ARG          
SEQRES 315 B 4128  GLY SER LYS ASP HIS ASN ILE ARG ALA GLN GLU PRO GLU          
SEQRES 316 B 4128  SER GLY LEU SER GLU GLU THR GLN VAL LYS CYS LEU MSE          
SEQRES 317 B 4128  ASP GLN ALA THR ASP PRO ASN ILE LEU GLY ARG THR TRP          
SEQRES 318 B 4128  GLU GLY TRP GLU PRO TRP MSE                                  
SEQRES   1 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   2 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   3 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   4 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   5 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   6 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   7 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   8 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   9 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  10 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  11 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  12 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  13 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  14 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  15 S  194  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK MSE UNK              
MODRES 5LUQ MSE A   96  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  144  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  189  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  208  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  238  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  326  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  333  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  342  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  384  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  395  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  410  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  441  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  453  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  540  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  541  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  602  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  718  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  754  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  785  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  858  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  879  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  880  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  901  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  937  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  939  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  941  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  948  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  958  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A  989  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1108  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1303  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1342  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1369  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1392  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1403  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1408  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1583  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1592  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1600  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1643  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1724  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1743  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1757  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1762  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1804  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1871  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1880  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1927  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 1998  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2025  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2040  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2085  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2094  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2104  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2126  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2185  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2220  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2281  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2307  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2331  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2356  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2379  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2408  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2424  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2442  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2443  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2473  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2478  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2565  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2568  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 2820  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3044  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3069  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3111  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3173  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3176  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3238  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3240  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3242  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3256  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3414  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3450  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3483  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3502  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3609  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3613  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3654  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3665  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3670  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3687  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3729  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3771  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3796  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3820  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3846  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3856  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3858  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3890  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3929  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3932  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3959  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3971  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3974  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3980  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 3984  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 4002  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 4020  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE A 4108  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B   96  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  144  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  189  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  208  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  238  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  326  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  333  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  342  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  384  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  395  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  410  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  441  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  453  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  540  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  541  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  602  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  718  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  754  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  785  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  858  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  879  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  880  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  901  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  937  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  939  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  941  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  948  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  958  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B  989  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1108  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1303  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1342  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1369  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1392  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1403  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1408  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1583  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1592  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1600  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1643  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1724  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1743  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1757  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1762  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1804  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1871  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1880  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1927  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 1998  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2025  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2040  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2085  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2094  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2104  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2126  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2185  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2220  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2281  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2307  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2331  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2356  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2379  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2408  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2424  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2442  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2443  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2473  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2478  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2565  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2568  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 2820  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3044  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3069  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3111  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3173  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3176  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3238  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3240  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3242  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3256  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3414  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3450  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3483  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3502  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3609  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3613  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3654  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3665  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3670  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3687  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3729  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3771  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3796  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3820  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3846  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3856  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3858  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3890  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3929  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3932  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3959  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3971  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3974  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3980  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 3984  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 4002  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 4020  MET  MODIFIED RESIDUE                                   
MODRES 5LUQ MSE B 4108  MET  MODIFIED RESIDUE                                   
HET    MSE  A  96       8                                                       
HET    MSE  A 144       8                                                       
HET    MSE  A 189       8                                                       
HET    MSE  A 208       8                                                       
HET    MSE  A 238       8                                                       
HET    MSE  A 326       8                                                       
HET    MSE  A 333       8                                                       
HET    MSE  A 342       8                                                       
HET    MSE  A 384       8                                                       
HET    MSE  A 395       8                                                       
HET    MSE  A 410       8                                                       
HET    MSE  A 441       8                                                       
HET    MSE  A 453       8                                                       
HET    MSE  A 540       8                                                       
HET    MSE  A 541       8                                                       
HET    MSE  A 602       8                                                       
HET    MSE  A 718       8                                                       
HET    MSE  A 754       8                                                       
HET    MSE  A 785       8                                                       
HET    MSE  A 858       8                                                       
HET    MSE  A 879       8                                                       
HET    MSE  A 880       8                                                       
HET    MSE  A 901       8                                                       
HET    MSE  A 937       8                                                       
HET    MSE  A 939       8                                                       
HET    MSE  A 941       8                                                       
HET    MSE  A 948       8                                                       
HET    MSE  A 958       8                                                       
HET    MSE  A 989       8                                                       
HET    MSE  A1108       8                                                       
HET    MSE  A1303       8                                                       
HET    MSE  A1342       8                                                       
HET    MSE  A1369       8                                                       
HET    MSE  A1392       8                                                       
HET    MSE  A1403       8                                                       
HET    MSE  A1408       8                                                       
HET    MSE  A1583       8                                                       
HET    MSE  A1592       8                                                       
HET    MSE  A1600       8                                                       
HET    MSE  A1643       8                                                       
HET    MSE  A1724       8                                                       
HET    MSE  A1743       8                                                       
HET    MSE  A1757       8                                                       
HET    MSE  A1762       8                                                       
HET    MSE  A1804       8                                                       
HET    MSE  A1871       8                                                       
HET    MSE  A1880       8                                                       
HET    MSE  A1927       8                                                       
HET    MSE  A1998       8                                                       
HET    MSE  A2025       8                                                       
HET    MSE  A2040       8                                                       
HET    MSE  A2085       8                                                       
HET    MSE  A2094       8                                                       
HET    MSE  A2104       8                                                       
HET    MSE  A2126       8                                                       
HET    MSE  A2185       8                                                       
HET    MSE  A2220       8                                                       
HET    MSE  A2281       8                                                       
HET    MSE  A2307       8                                                       
HET    MSE  A2331       8                                                       
HET    MSE  A2356       8                                                       
HET    MSE  A2379       8                                                       
HET    MSE  A2408       8                                                       
HET    MSE  A2424       8                                                       
HET    MSE  A2442       8                                                       
HET    MSE  A2443       8                                                       
HET    MSE  A2473       8                                                       
HET    MSE  A2478       8                                                       
HET    MSE  A2565       8                                                       
HET    MSE  A2568       8                                                       
HET    MSE  A2576       8                                                       
HET    MSE  A2820       8                                                       
HET    MSE  A3044       8                                                       
HET    MSE  A3069       8                                                       
HET    MSE  A3111       8                                                       
HET    MSE  A3173       8                                                       
HET    MSE  A3176       8                                                       
HET    MSE  A3238       8                                                       
HET    MSE  A3240       8                                                       
HET    MSE  A3242       8                                                       
HET    MSE  A3256       8                                                       
HET    MSE  A3414       8                                                       
HET    MSE  A3450       8                                                       
HET    MSE  A3483       8                                                       
HET    MSE  A3502       8                                                       
HET    MSE  A3609       8                                                       
HET    MSE  A3613       8                                                       
HET    MSE  A3654       8                                                       
HET    MSE  A3665       8                                                       
HET    MSE  A3670       8                                                       
HET    MSE  A3687       8                                                       
HET    MSE  A3729       8                                                       
HET    MSE  A3771       8                                                       
HET    MSE  A3796       8                                                       
HET    MSE  A3820       8                                                       
HET    MSE  A3846       8                                                       
HET    MSE  A3856       8                                                       
HET    MSE  A3858       8                                                       
HET    MSE  A3890       8                                                       
HET    MSE  A3929       8                                                       
HET    MSE  A3932       8                                                       
HET    MSE  A3959       8                                                       
HET    MSE  A3971       8                                                       
HET    MSE  A3974       8                                                       
HET    MSE  A3980       8                                                       
HET    MSE  A3984       8                                                       
HET    MSE  A4002       8                                                       
HET    MSE  A4020       8                                                       
HET    MSE  A4108       8                                                       
HET    MSE  A4128       8                                                       
HET    MSE  K 220       8                                                       
HET    MSE  B  96       8                                                       
HET    MSE  B 144       8                                                       
HET    MSE  B 189       8                                                       
HET    MSE  B 208       8                                                       
HET    MSE  B 238       8                                                       
HET    MSE  B 326       8                                                       
HET    MSE  B 333       8                                                       
HET    MSE  B 342       8                                                       
HET    MSE  B 384       8                                                       
HET    MSE  B 395       8                                                       
HET    MSE  B 410       8                                                       
HET    MSE  B 441       8                                                       
HET    MSE  B 453       8                                                       
HET    MSE  B 540       8                                                       
HET    MSE  B 541       8                                                       
HET    MSE  B 602       8                                                       
HET    MSE  B 718       8                                                       
HET    MSE  B 754       8                                                       
HET    MSE  B 785       8                                                       
HET    MSE  B 858       8                                                       
HET    MSE  B 879       8                                                       
HET    MSE  B 880       8                                                       
HET    MSE  B 901       8                                                       
HET    MSE  B 937       8                                                       
HET    MSE  B 939       8                                                       
HET    MSE  B 941       8                                                       
HET    MSE  B 948       8                                                       
HET    MSE  B 958       8                                                       
HET    MSE  B 989       8                                                       
HET    MSE  B1108       8                                                       
HET    MSE  B1303       8                                                       
HET    MSE  B1342       8                                                       
HET    MSE  B1369       8                                                       
HET    MSE  B1392       8                                                       
HET    MSE  B1403       8                                                       
HET    MSE  B1408       8                                                       
HET    MSE  B1583       8                                                       
HET    MSE  B1592       8                                                       
HET    MSE  B1600       8                                                       
HET    MSE  B1643       8                                                       
HET    MSE  B1724       8                                                       
HET    MSE  B1743       8                                                       
HET    MSE  B1757       8                                                       
HET    MSE  B1762       8                                                       
HET    MSE  B1804       8                                                       
HET    MSE  B1871       8                                                       
HET    MSE  B1880       8                                                       
HET    MSE  B1927       8                                                       
HET    MSE  B1998       8                                                       
HET    MSE  B2025       8                                                       
HET    MSE  B2040       8                                                       
HET    MSE  B2085       8                                                       
HET    MSE  B2094       8                                                       
HET    MSE  B2104       8                                                       
HET    MSE  B2126       8                                                       
HET    MSE  B2185       8                                                       
HET    MSE  B2220       8                                                       
HET    MSE  B2281       8                                                       
HET    MSE  B2307       8                                                       
HET    MSE  B2331       8                                                       
HET    MSE  B2356       8                                                       
HET    MSE  B2379       8                                                       
HET    MSE  B2408       8                                                       
HET    MSE  B2424       8                                                       
HET    MSE  B2442       8                                                       
HET    MSE  B2443       8                                                       
HET    MSE  B2473       8                                                       
HET    MSE  B2478       8                                                       
HET    MSE  B2565       8                                                       
HET    MSE  B2568       8                                                       
HET    MSE  B2576       8                                                       
HET    MSE  B2820       8                                                       
HET    MSE  B3044       8                                                       
HET    MSE  B3069       8                                                       
HET    MSE  B3111       8                                                       
HET    MSE  B3173       8                                                       
HET    MSE  B3176       8                                                       
HET    MSE  B3238       8                                                       
HET    MSE  B3240       8                                                       
HET    MSE  B3242       8                                                       
HET    MSE  B3256       8                                                       
HET    MSE  B3414       8                                                       
HET    MSE  B3450       8                                                       
HET    MSE  B3483       8                                                       
HET    MSE  B3502       8                                                       
HET    MSE  B3609       8                                                       
HET    MSE  B3613       8                                                       
HET    MSE  B3654       8                                                       
HET    MSE  B3665       8                                                       
HET    MSE  B3670       8                                                       
HET    MSE  B3687       8                                                       
HET    MSE  B3729       8                                                       
HET    MSE  B3771       8                                                       
HET    MSE  B3796       8                                                       
HET    MSE  B3820       8                                                       
HET    MSE  B3846       8                                                       
HET    MSE  B3856       8                                                       
HET    MSE  B3858       8                                                       
HET    MSE  B3890       8                                                       
HET    MSE  B3929       8                                                       
HET    MSE  B3932       8                                                       
HET    MSE  B3959       8                                                       
HET    MSE  B3971       8                                                       
HET    MSE  B3974       8                                                       
HET    MSE  B3980       8                                                       
HET    MSE  B3984       8                                                       
HET    MSE  B4002       8                                                       
HET    MSE  B4020       8                                                       
HET    MSE  B4108       8                                                       
HET    MSE  B4128       8                                                       
HET    MSE  S 220       8                                                       
HETNAM     MSE SELENOMETHIONINE                                                 
FORMUL   1  MSE    222(C5 H11 N O2 SE)                                          
HELIX    1 AA1 CYS A   10  SER A   20  1                                  11    
HELIX    2 AA2 ALA A   28  LEU A   44  1                                  17    
HELIX    3 AA3 ALA A   49  SER A   72  1                                  24    
HELIX    4 AA4 GLU A   77  GLU A   94  1                                  18    
HELIX    5 AA5 ILE A  100  ASP A  118  1                                  19    
HELIX    6 AA6 ILE A  125  SER A  140  1                                  16    
HELIX    7 AA7 PHE A  147  LEU A  162  1                                  16    
HELIX    8 AA8 LEU A  171  GLU A  183  1                                  13    
HELIX    9 AA9 PRO A  186  ALA A  211  1                                  26    
HELIX   10 AB1 LYS A  216  THR A  235  1                                  20    
HELIX   11 AB2 GLU A  239  LEU A  253  1                                  15    
HELIX   12 AB3 ILE A  260  LEU A  274  1                                  15    
HELIX   13 AB4 HIS A  278  LEU A  286  1                                   9    
HELIX   14 AB5 TYR A  290  THR A  304  1                                  15    
HELIX   15 AB6 LEU A  308  LYS A  329  1                                  22    
HELIX   16 AB7 LYS A  335  ASN A  351  1                                  17    
HELIX   17 AB8 GLU A  358  VAL A  375  1                                  18    
HELIX   18 AB9 ILE A  376  LYS A  379  5                                   4    
HELIX   19 AC1 ASP A  382  THR A  398  1                                  17    
HELIX   20 AC2 GLN A  399  ASP A  401  5                                   3    
HELIX   21 AC3 PRO A  411  LEU A  421  1                                  11    
HELIX   22 AC4 VAL A  430  SER A  445  1                                  16    
HELIX   23 AC5 SER A  450  LYS A  471  1                                  22    
HELIX   24 AC6 VAL A  474  CYS A  491  1                                  18    
HELIX   25 AC7 GLU A  504  VAL A  514  1                                  11    
HELIX   26 AC8 VAL A  528  GLN A  539  1                                  12    
HELIX   27 AC9 ILE A  544  TYR A  565  1                                  22    
HELIX   28 AD1 GLU A  567  VAL A  576  1                                  10    
HELIX   29 AD2 LYS A  578  GLU A  584  1                                   7    
HELIX   30 AD3 THR A  587  GLU A  596  1                                  10    
HELIX   31 AD4 PRO A  608  ASN A  625  1                                  18    
HELIX   32 AD5 GLU A  632  SER A  650  1                                  19    
HELIX   33 AD6 LEU A  653  TYR A  667  1                                  15    
HELIX   34 AD7 SER A  671  TYR A  682  1                                  12    
HELIX   35 AD8 TYR A  701  GLN A  720  1                                  20    
HELIX   36 AD9 ASP A  723  GLU A  742  1                                  20    
HELIX   37 AE1 LEU A  743  VAL A  745  5                                   3    
HELIX   38 AE2 VAL A  749  GLY A  759  1                                  11    
HELIX   39 AE3 GLU A  767  ARG A  782  1                                  16    
HELIX   40 AE4 ILE A  792  LYS A  801  1                                  10    
HELIX   41 AE5 SER A  847  SER A  861  1                                  15    
HELIX   42 AE6 ILE A  866  ASP A  877  1                                  12    
HELIX   43 AE7 TYR A  883  GLU A  889  1                                   7    
HELIX   44 AE8 PHE A  910  THR A  920  1                                  11    
HELIX   45 AE9 GLN A  925  LYS A  944  1                                  20    
HELIX   46 AF1 GLY A  951  GLN A  953  5                                   3    
HELIX   47 AF2 GLY A  954  THR A  965  1                                  12    
HELIX   48 AF3 PHE A  966  ASP A  975  1                                  10    
HELIX   49 AF4 GLN A  978  PHE A  995  1                                  18    
HELIX   50 AF5 SER A 1003  GLU A 1011  1                                   9    
HELIX   51 AF6 ALA A 1012  ILE A 1017  1                                   6    
HELIX   52 AF7 ASP A 1022  LYS A 1042  1                                  21    
HELIX   53 AF8 THR A 1045  SER A 1052  1                                   8    
HELIX   54 AF9 THR A 1056  LEU A 1068  1                                  13    
HELIX   55 AG1 ARG A 1075  GLU A 1091  1                                  17    
HELIX   56 AG2 LEU A 1095  GLU A 1118  1                                  24    
HELIX   57 AG3 THR A 1123  ARG A 1136  1                                  14    
HELIX   58 AG4 ILE A 1137  GLU A 1139  5                                   3    
HELIX   59 AG5 SER A 1144  PHE A 1157  1                                  14    
HELIX   60 AG6 LEU A 1165  ARG A 1178  1                                  14    
HELIX   61 AG7 GLY A 1216  GLY A 1227  1                                  12    
HELIX   62 AG8 GLN A 1238  ARG A 1245  1                                   8    
HELIX   63 AG9 PHE A 1248  THR A 1253  1                                   6    
HELIX   64 AH1 TRP A 1256  GLY A 1272  1                                  17    
HELIX   65 AH2 GLU A 1273  ALA A 1278  1                                   6    
HELIX   66 AH3 LEU A 1291  ALA A 1308  1                                  18    
HELIX   67 AH4 PRO A 1324  ASN A 1350  1                                  27    
HELIX   68 AH5 PRO A 1353  LYS A 1357  5                                   5    
HELIX   69 AH6 LEU A 1358  LEU A 1363  5                                   6    
HELIX   70 AH7 CYS A 1364  VAL A 1373  1                                  10    
HELIX   71 AH8 LEU A 1376  ILE A 1382  1                                   7    
HELIX   72 AH9 PHE A 1384  VAL A 1389  1                                   6    
HELIX   73 AI1 HIS A 1394  LYS A 1407  1                                  14    
HELIX   74 AI2 TYR A 1411  LEU A 1419  1                                   9    
HELIX   75 AI3 ALA A 1425  GLY A 1438  1                                  14    
HELIX   76 AI4 ASP A 1440  ARG A 1460  1                                  21    
HELIX   77 AI5 LEU A 1463  LEU A 1468  1                                   6    
HELIX   78 AI6 PRO A 1469  ASP A 1474  1                                   6    
HELIX   79 AI7 ASP A 1474  GLY A 1490  1                                  17    
HELIX   80 AI8 ASP A 1495  GLN A 1509  1                                  15    
HELIX   81 AI9 GLY A 1513  GLU A 1526  1                                  14    
HELIX   82 AJ1 SER A 1549  SER A 1561  1                                  13    
HELIX   83 AJ2 LEU A 1562  SER A 1564  5                                   3    
HELIX   84 AJ3 THR A 1566  ALA A 1578  1                                  13    
HELIX   85 AJ4 LEU A 1580  THR A 1590  1                                  11    
HELIX   86 AJ5 MSE A 1592  ALA A 1609  1                                  18    
HELIX   87 AJ6 SER A 1631  VAL A 1645  1                                  15    
HELIX   88 AJ7 LEU A 1648  SER A 1658  1                                  11    
HELIX   89 AJ8 PHE A 1672  LEU A 1696  1                                  25    
HELIX   90 AJ9 SER A 1701  SER A 1706  1                                   6    
HELIX   91 AK1 LEU A 1710  LEU A 1717  1                                   8    
HELIX   92 AK2 ILE A 1718  ALA A 1720  5                                   3    
HELIX   93 AK3 PHE A 1722  SER A 1726  5                                   5    
HELIX   94 AK4 TYR A 1739  SER A 1753  1                                  15    
HELIX   95 AK5 ARG A 1788  LEU A 1797  1                                  10    
HELIX   96 AK6 VAL A 1801  ASP A 1809  1                                   9    
HELIX   97 AK7 SER A 1813  ARG A 1822  1                                  10    
HELIX   98 AK8 LYS A 1857  TYR A 1873  1                                  17    
HELIX   99 AK9 TYR A 1874  LEU A 1877  5                                   4    
HELIX  100 AL1 VAL A 1879  HIS A 1890  1                                  12    
HELIX  101 AL2 LYS A 1895  THR A 1912  1                                  18    
HELIX  102 AL3 LEU A 1915  MSE A 1927  1                                  13    
HELIX  103 AL4 GLU A 1935  SER A 1950  1                                  16    
HELIX  104 AL5 PHE A 1956  LYS A 1970  1                                  15    
HELIX  105 AL6 PHE A 1978  TYR A 1988  1                                  11    
HELIX  106 AL7 TYR A 1988  VAL A 1996  1                                   9    
HELIX  107 AL8 ALA A 2014  TYR A 2024  1                                  11    
HELIX  108 AL9 MSE A 2040  GLN A 2050  1                                  11    
HELIX  109 AM1 SER A 2051  SER A 2056  5                                   6    
HELIX  110 AM2 ASP A 2058  ARG A 2065  1                                   8    
HELIX  111 AM3 ARG A 2072  ASP A 2079  1                                   8    
HELIX  112 AM4 LEU A 2083  ASN A 2089  1                                   7    
HELIX  113 AM5 CYS A 2093  ARG A 2106  1                                  14    
HELIX  114 AM6 SER A 2117  LEU A 2122  1                                   6    
HELIX  115 AM7 SER A 2124  LEU A 2129  5                                   6    
HELIX  116 AM8 PRO A 2136  LYS A 2148  1                                  13    
HELIX  117 AM9 VAL A 2156  SER A 2166  1                                  11    
HELIX  118 AN1 LEU A 2168  SER A 2174  1                                   7    
HELIX  119 AN2 GLY A 2178  SER A 2195  1                                  18    
HELIX  120 AN3 LYS A 2207  ARG A 2228  1                                  22    
HELIX  121 AN4 HIS A 2233  LYS A 2246  1                                  14    
HELIX  122 AN5 PRO A 2252  SER A 2261  1                                  10    
HELIX  123 AN6 LYS A 2268  ALA A 2282  1                                  15    
HELIX  124 AN7 ASP A 2284  ASP A 2289  1                                   6    
HELIX  125 AN8 GLU A 2298  SER A 2308  1                                  11    
HELIX  126 AN9 GLU A 2314  ARG A 2333  1                                  20    
HELIX  127 AO1 ASN A 2335  MSE A 2356  1                                  22    
HELIX  128 AO2 GLU A 2357  LYS A 2369  1                                  13    
HELIX  129 AO3 LEU A 2374  GLY A 2391  1                                  18    
HELIX  130 AO4 GLU A 2399  THR A 2409  1                                  11    
HELIX  131 AO5 TYR A 2412  MSE A 2424  1                                  13    
HELIX  132 AO6 ARG A 2425  ARG A 2427  5                                   3    
HELIX  133 AO7 GLU A 2430  GLN A 2432  5                                   3    
HELIX  134 AO8 LYS A 2433  TYR A 2440  1                                   8    
HELIX  135 AO9 PRO A 2448  SER A 2463  1                                  16    
HELIX  136 AP1 CYS A 2469  ARG A 2485  1                                  17    
HELIX  137 AP2 ASP A 2494  LEU A 2510  1                                  17    
HELIX  138 AP3 PRO A 2515  GLU A 2528  1                                  14    
HELIX  139 AP4 ASN A 2534  SER A 2547  1                                  14    
HELIX  140 AP5 PRO A 2548  ILE A 2550  5                                   3    
HELIX  141 AP6 HIS A 2553  MSE A 2568  1                                  16    
HELIX  142 AP7 UNK A 2604  UNK A 2610  1                                   7    
HELIX  143 AP8 UNK A 2621  UNK A 2648  1                                  28    
HELIX  144 AP9 UNK A 2657  UNK A 2665  1                                   9    
HELIX  145 AQ1 TYR A 2775  ILE A 2783  1                                   9    
HELIX  146 AQ2 LEU A 2790  ASP A 2801  1                                  12    
HELIX  147 AQ3 LYS A 2806  LYS A 2818  1                                  13    
HELIX  148 AQ4 LYS A 2818  PHE A 2823  1                                   6    
HELIX  149 AQ5 LEU A 2826  GLN A 2834  1                                   9    
HELIX  150 AQ6 LYS A 2835  THR A 2847  1                                  13    
HELIX  151 AQ7 PHE A 2850  CYS A 2863  1                                  14    
HELIX  152 AQ8 ALA A 2866  LEU A 2871  1                                   6    
HELIX  153 AQ9 GLN A 2886  LEU A 2897  1                                  12    
HELIX  154 AR1 GLY A 2912  ALA A 2914  5                                   3    
HELIX  155 AR2 ARG A 2915  GLU A 2925  1                                  11    
HELIX  156 AR3 LEU A 2929  GLY A 2941  1                                  13    
HELIX  157 AR4 SER A 2945  LEU A 2957  1                                  13    
HELIX  158 AR5 SER A 2963  ALA A 2975  1                                  13    
HELIX  159 AR6 GLU A 2988  HIS A 3004  1                                  17    
HELIX  160 AR7 TRP A 3008  ILE A 3019  1                                  12    
HELIX  161 AR8 PRO A 3025  TRP A 3031  1                                   7    
HELIX  162 AR9 TYR A 3036  GLU A 3038  5                                   3    
HELIX  163 AS1 THR A 3039  GLY A 3055  1                                  17    
HELIX  164 AS2 ASP A 3058  GLY A 3071  1                                  14    
HELIX  165 AS3 LYS A 3075  SER A 3083  1                                   9    
HELIX  166 AS4 GLN A 3084  LEU A 3089  1                                   6    
HELIX  167 AS5 TYR A 3090  ASP A 3094  5                                   5    
HELIX  168 AS6 ASP A 3097  TYR A 3114  1                                  18    
HELIX  169 AS7 LEU A 3121  LEU A 3126  1                                   6    
HELIX  170 AS8 THR A 3127  LEU A 3151  1                                  25    
HELIX  171 AS9 GLN A 3154  LYS A 3158  5                                   5    
HELIX  172 AT1 LEU A 3160  TYR A 3168  1                                   9    
HELIX  173 AT2 ASN A 3177  THR A 3198  1                                  22    
HELIX  174 AT3 SER A 3228  ASN A 3250  1                                  23    
HELIX  175 AT4 SER A 3253  SER A 3266  1                                  14    
HELIX  176 AT5 THR A 3268  SER A 3288  1                                  21    
HELIX  177 AT6 GLU A 3295  LYS A 3302  1                                   8    
HELIX  178 AT7 LYS A 3318  TYR A 3334  1                                  17    
HELIX  179 AT8 CYS A 3347  ILE A 3359  1                                  13    
HELIX  180 AT9 ILE A 3374  GLN A 3379  1                                   6    
HELIX  181 AU1 ARG A 3380  GLU A 3395  1                                  16    
HELIX  182 AU2 ALA A 3396  GLY A 3404  1                                   9    
HELIX  183 AU3 GLY A 3408  GLU A 3429  1                                  22    
HELIX  184 AU4 SER A 3432  GLN A 3440  1                                   9    
HELIX  185 AU5 GLU A 3448  ALA A 3453  1                                   6    
HELIX  186 AU6 SER A 3458  ILE A 3472  1                                  15    
HELIX  187 AU7 GLU A 3477  VAL A 3490  1                                  14    
HELIX  188 AU8 PRO A 3491  PHE A 3495  5                                   5    
HELIX  189 AU9 TRP A 3498  LYS A 3508  1                                  11    
HELIX  190 AV1 HIS A 3516  TYR A 3525  1                                  10    
HELIX  191 AV2 VAL A 3530  TYR A 3540  1                                  11    
HELIX  192 AV3 SER A 3541  LYS A 3543  5                                   3    
HELIX  193 AV4 GLY A 3548  LYS A 3561  1                                  14    
HELIX  194 AV5 GLY A 3566  GLN A 3577  1                                  12    
HELIX  195 AV6 ASN A 3580  ALA A 3594  1                                  15    
HELIX  196 AV7 LYS A 3603  TYR A 3610  1                                   8    
HELIX  197 AV8 TYR A 3610  GLY A 3618  1                                   9    
HELIX  198 AV9 ALA A 3622  ALA A 3627  1                                   6    
HELIX  199 AW1 ARG A 3630  THR A 3635  1                                   6    
HELIX  200 AW2 THR A 3635  ARG A 3653  1                                  19    
HELIX  201 AW3 ASP A 3658  ASP A 3673  1                                  16    
HELIX  202 AW4 GLU A 3682  SER A 3688  1                                   7    
HELIX  203 AW5 GLU A 3693  LEU A 3699  1                                   7    
HELIX  204 AW6 ASP A 3761  ASN A 3772  1                                  12    
HELIX  205 AW7 ASP A 3778  ARG A 3784  1                                   7    
HELIX  206 AW8 THR A 3811  GLU A 3824  1                                  14    
HELIX  207 AW9 PRO A 3835  LYS A 3845  1                                  11    
HELIX  208 AX1 GLY A 3861  MSE A 3890  1                                  30    
HELIX  209 AX2 GLU A 3895  LEU A 3918  1                                  24    
HELIX  210 AX3 PHE A 3946  PHE A 3952  1                                   7    
HELIX  211 AX4 THR A 3964  MSE A 3971  1                                   8    
HELIX  212 AX5 GLU A 3976  SER A 3993  1                                  18    
HELIX  213 AX6 ASP A 3994  GLU A 4008  1                                  15    
HELIX  214 AX7 ASN A 4015  GLY A 4024  1                                  10    
HELIX  215 AX8 GLY A 4025  GLU A 4035  1                                  11    
HELIX  216 AX9 ARG A 4041  ALA A 4054  1                                  14    
HELIX  217 AY1 VAL A 4058  GLY A 4067  1                                  10    
HELIX  218 AY2 LYS A 4070  ALA A 4079  1                                  10    
HELIX  219 AY3 VAL A 4080  GLY A 4083  5                                   4    
HELIX  220 AY4 SER A 4084  GLU A 4093  1                                  10    
HELIX  221 AY5 GLU A 4101  GLN A 4110  1                                  10    
HELIX  222 AY6 ASP A 4113  THR A 4120  1                                   8    
HELIX  223 AY7 UNK K  102  UNK K  108  1                                   7    
HELIX  224 AY8 UNK K  116  UNK K  133  1                                  18    
HELIX  225 AY9 UNK K  213  MSE K  220  1                                   8    
HELIX  226 AZ1 SER B   11  SER B   20  1                                  10    
HELIX  227 AZ2 ALA B   28  LEU B   44  1                                  17    
HELIX  228 AZ3 ALA B   49  SER B   72  1                                  24    
HELIX  229 AZ4 GLU B   77  GLY B   97  1                                  21    
HELIX  230 AZ5 ALA B  101  ASP B  118  1                                  18    
HELIX  231 AZ6 ILE B  125  SER B  140  1                                  16    
HELIX  232 AZ7 PHE B  147  LEU B  162  1                                  16    
HELIX  233 AZ8 VAL B  170  VAL B  184  1                                  15    
HELIX  234 AZ9 PRO B  186  MSE B  208  1                                  23    
HELIX  235 BA1 LYS B  216  THR B  235  1                                  20    
HELIX  236 BA2 GLU B  239  LEU B  253  1                                  15    
HELIX  237 BA3 ILE B  260  PHE B  275  1                                  16    
HELIX  238 BA4 HIS B  278  LEU B  286  1                                   9    
HELIX  239 BA5 ASN B  289  THR B  304  1                                  16    
HELIX  240 BA6 LEU B  308  LYS B  329  1                                  22    
HELIX  241 BA7 LYS B  335  ASN B  351  1                                  17    
HELIX  242 BA8 VAL B  352  SER B  354  5                                   3    
HELIX  243 BA9 GLU B  358  VAL B  375  1                                  18    
HELIX  244 BB1 ILE B  376  LYS B  379  5                                   4    
HELIX  245 BB2 ASP B  382  THR B  398  1                                  17    
HELIX  246 BB3 GLN B  399  ASP B  401  5                                   3    
HELIX  247 BB4 PRO B  411  LEU B  421  1                                  11    
HELIX  248 BB5 VAL B  430  SER B  445  1                                  16    
HELIX  249 BB6 SER B  450  LYS B  471  1                                  22    
HELIX  250 BB7 VAL B  474  CYS B  491  1                                  18    
HELIX  251 BB8 GLU B  504  VAL B  514  1                                  11    
HELIX  252 BB9 ASP B  529  GLN B  539  1                                  11    
HELIX  253 BC1 ILE B  544  TYR B  565  1                                  22    
HELIX  254 BC2 GLU B  567  GLU B  584  1                                  18    
HELIX  255 BC3 THR B  587  ALA B  597  1                                  11    
HELIX  256 BC4 PRO B  608  ASN B  625  1                                  18    
HELIX  257 BC5 PRO B  635  SER B  650  1                                  16    
HELIX  258 BC6 LEU B  653  ARG B  659  1                                   7    
HELIX  259 BC7 LEU B  660  TYR B  667  1                                   8    
HELIX  260 BC8 SER B  671  TYR B  682  1                                  12    
HELIX  261 BC9 TYR B  701  LYS B  722  1                                  22    
HELIX  262 BD1 ASP B  723  ILE B  741  1                                  19    
HELIX  263 BD2 VAL B  749  GLY B  759  1                                  11    
HELIX  264 BD3 LEU B  770  ARG B  782  1                                  13    
HELIX  265 BD4 ILE B  792  LYS B  801  1                                  10    
HELIX  266 BD5 SER B  803  GLU B  808  1                                   6    
HELIX  267 BD6 SER B  847  GLY B  863  1                                  17    
HELIX  268 BD7 ASN B  867  ASP B  877  1                                  11    
HELIX  269 BD8 TYR B  883  ARG B  888  1                                   6    
HELIX  270 BD9 VAL B  909  LEU B  919  1                                  11    
HELIX  271 BE1 GLN B  925  LYS B  944  1                                  20    
HELIX  272 BE2 GLY B  951  GLN B  953  5                                   3    
HELIX  273 BE3 GLY B  954  ASP B  975  1                                  22    
HELIX  274 BE4 GLN B  978  PHE B  995  1                                  18    
HELIX  275 BE5 LYS B 1000  GLU B 1002  5                                   3    
HELIX  276 BE6 SER B 1003  GLU B 1011  1                                   9    
HELIX  277 BE7 ASP B 1022  SER B 1040  1                                  19    
HELIX  278 BE8 THR B 1045  SER B 1052  1                                   8    
HELIX  279 BE9 ASN B 1055  LEU B 1068  1                                  14    
HELIX  280 BF1 ARG B 1075  GLU B 1091  1                                  17    
HELIX  281 BF2 LEU B 1095  GLU B 1118  1                                  24    
HELIX  282 BF3 THR B 1123  ARG B 1136  1                                  14    
HELIX  283 BF4 ILE B 1137  GLU B 1139  5                                   3    
HELIX  284 BF5 ALA B 1148  GLY B 1156  1                                   9    
HELIX  285 BF6 LEU B 1165  ARG B 1178  1                                  14    
HELIX  286 BF7 GLY B 1216  GLY B 1227  1                                  12    
HELIX  287 BF8 PRO B 1239  ARG B 1245  1                                   7    
HELIX  288 BF9 PRO B 1247  ALA B 1252  1                                   6    
HELIX  289 BG1 TRP B 1256  GLY B 1272  1                                  17    
HELIX  290 BG2 GLU B 1273  ALA B 1278  1                                   6    
HELIX  291 BG3 LEU B 1291  ALA B 1308  1                                  18    
HELIX  292 BG4 PRO B 1324  ASN B 1350  1                                  27    
HELIX  293 BG5 PRO B 1353  LYS B 1357  5                                   5    
HELIX  294 BG6 LEU B 1358  LEU B 1363  5                                   6    
HELIX  295 BG7 CYS B 1364  VAL B 1373  1                                  10    
HELIX  296 BG8 LEU B 1376  ILE B 1382  1                                   7    
HELIX  297 BG9 PHE B 1384  VAL B 1389  1                                   6    
HELIX  298 BH1 HIS B 1394  ALA B 1405  1                                  12    
HELIX  299 BH2 TYR B 1411  ARG B 1420  1                                  10    
HELIX  300 BH3 ALA B 1425  GLY B 1438  1                                  14    
HELIX  301 BH4 ASP B 1440  ARG B 1460  1                                  21    
HELIX  302 BH5 LEU B 1463  LEU B 1468  1                                   6    
HELIX  303 BH6 PRO B 1469  ASP B 1474  1                                   6    
HELIX  304 BH7 ASP B 1474  GLY B 1490  1                                  17    
HELIX  305 BH8 ASP B 1495  GLN B 1509  1                                  15    
HELIX  306 BH9 GLY B 1513  GLU B 1526  1                                  14    
HELIX  307 BI1 SER B 1549  SER B 1561  1                                  13    
HELIX  308 BI2 LEU B 1562  SER B 1564  5                                   3    
HELIX  309 BI3 THR B 1566  ALA B 1578  1                                  13    
HELIX  310 BI4 LEU B 1580  THR B 1590  1                                  11    
HELIX  311 BI5 MSE B 1592  ALA B 1609  1                                  18    
HELIX  312 BI6 SER B 1631  VAL B 1645  1                                  15    
HELIX  313 BI7 LEU B 1646  SER B 1658  1                                  13    
HELIX  314 BI8 PHE B 1672  THR B 1694  1                                  23    
HELIX  315 BI9 SER B 1701  LEU B 1707  1                                   7    
HELIX  316 BJ1 LEU B 1710  VAL B 1719  1                                  10    
HELIX  317 BJ2 GLN B 1725  PHE B 1729  5                                   5    
HELIX  318 BJ3 ASN B 1738  SER B 1755  1                                  18    
HELIX  319 BJ4 ARG B 1788  GLY B 1796  1                                   9    
HELIX  320 BJ5 LEU B 1798  ASP B 1809  1                                  12    
HELIX  321 BJ6 SER B 1813  ARG B 1822  1                                  10    
HELIX  322 BJ7 LYS B 1857  TYR B 1873  1                                  17    
HELIX  323 BJ8 TYR B 1874  LEU B 1877  5                                   4    
HELIX  324 BJ9 VAL B 1879  HIS B 1890  1                                  12    
HELIX  325 BK1 LYS B 1895  THR B 1912  1                                  18    
HELIX  326 BK2 LYS B 1913  ALA B 1928  1                                  16    
HELIX  327 BK3 GLU B 1935  SER B 1950  1                                  16    
HELIX  328 BK4 PHE B 1956  LYS B 1970  1                                  15    
HELIX  329 BK5 PHE B 1978  TYR B 1988  1                                  11    
HELIX  330 BK6 TYR B 1988  VAL B 1996  1                                   9    
HELIX  331 BK7 GLU B 2013  TYR B 2024  1                                  12    
HELIX  332 BK8 SER B 2041  VAL B 2049  1                                   9    
HELIX  333 BK9 GLN B 2050  SER B 2056  5                                   7    
HELIX  334 BL1 ASP B 2058  PHE B 2066  1                                   9    
HELIX  335 BL2 ARG B 2072  ASP B 2079  1                                   8    
HELIX  336 BL3 MSE B 2085  ARG B 2090  1                                   6    
HELIX  337 BL4 CYS B 2093  SER B 2107  1                                  15    
HELIX  338 BL5 SER B 2117  LEU B 2122  1                                   6    
HELIX  339 BL6 SER B 2124  LEU B 2129  5                                   6    
HELIX  340 BL7 PRO B 2136  LEU B 2149  1                                  14    
HELIX  341 BL8 VAL B 2156  SER B 2166  1                                  11    
HELIX  342 BL9 LEU B 2168  SER B 2174  1                                   7    
HELIX  343 BM1 GLY B 2178  SER B 2195  1                                  18    
HELIX  344 BM2 LYS B 2207  ARG B 2228  1                                  22    
HELIX  345 BM3 HIS B 2233  LYS B 2246  1                                  14    
HELIX  346 BM4 PRO B 2252  SER B 2261  1                                  10    
HELIX  347 BM5 LYS B 2268  ALA B 2282  1                                  15    
HELIX  348 BM6 ASP B 2284  ASP B 2289  1                                   6    
HELIX  349 BM7 GLU B 2298  SER B 2308  1                                  11    
HELIX  350 BM8 GLU B 2314  ARG B 2333  1                                  20    
HELIX  351 BM9 ASN B 2335  MSE B 2356  1                                  22    
HELIX  352 BN1 GLU B 2357  LYS B 2369  1                                  13    
HELIX  353 BN2 LEU B 2374  GLY B 2391  1                                  18    
HELIX  354 BN3 THR B 2395  MSE B 2408  1                                  14    
HELIX  355 BN4 TYR B 2412  VAL B 2423  1                                  12    
HELIX  356 BN5 MSE B 2424  ARG B 2427  5                                   4    
HELIX  357 BN6 ASP B 2429  TYR B 2440  1                                  12    
HELIX  358 BN7 PRO B 2448  SER B 2463  1                                  16    
HELIX  359 BN8 CYS B 2469  ARG B 2485  1                                  17    
HELIX  360 BN9 SER B 2495  LEU B 2510  1                                  16    
HELIX  361 BO1 PRO B 2515  GLU B 2528  1                                  14    
HELIX  362 BO2 ASN B 2534  SER B 2547  1                                  14    
HELIX  363 BO3 PRO B 2548  ILE B 2550  5                                   3    
HELIX  364 BO4 HIS B 2553  MSE B 2568  1                                  16    
HELIX  365 BO5 UNK B 2604  UNK B 2609  1                                   6    
HELIX  366 BO6 UNK B 2620  UNK B 2648  1                                  29    
HELIX  367 BO7 UNK B 2657  UNK B 2665  1                                   9    
HELIX  368 BO8 TYR B 2775  ILE B 2783  1                                   9    
HELIX  369 BO9 LEU B 2790  ASP B 2801  1                                  12    
HELIX  370 BP1 LYS B 2806  LYS B 2818  1                                  13    
HELIX  371 BP2 LYS B 2818  PHE B 2823  1                                   6    
HELIX  372 BP3 LEU B 2826  THR B 2847  1                                  22    
HELIX  373 BP4 PHE B 2850  CYS B 2863  1                                  14    
HELIX  374 BP5 HIS B 2865  LEU B 2871  1                                   7    
HELIX  375 BP6 PRO B 2873  SER B 2877  5                                   5    
HELIX  376 BP7 GLN B 2886  LEU B 2897  1                                  12    
HELIX  377 BP8 ARG B 2915  GLU B 2925  1                                  11    
HELIX  378 BP9 LEU B 2929  GLY B 2941  1                                  13    
HELIX  379 BQ1 SER B 2945  LEU B 2957  1                                  13    
HELIX  380 BQ2 SER B 2963  ALA B 2975  1                                  13    
HELIX  381 BQ3 GLU B 2988  HIS B 3004  1                                  17    
HELIX  382 BQ4 TRP B 3008  ILE B 3019  1                                  12    
HELIX  383 BQ5 PRO B 3025  TRP B 3031  1                                   7    
HELIX  384 BQ6 TYR B 3036  GLU B 3038  5                                   3    
HELIX  385 BQ7 THR B 3039  GLY B 3055  1                                  17    
HELIX  386 BQ8 ASP B 3058  GLY B 3071  1                                  14    
HELIX  387 BQ9 ALA B 3076  SER B 3083  1                                   8    
HELIX  388 BR1 GLN B 3084  LEU B 3089  1                                   6    
HELIX  389 BR2 TYR B 3090  ASP B 3094  5                                   5    
HELIX  390 BR3 ASP B 3097  TYR B 3114  1                                  18    
HELIX  391 BR4 LEU B 3121  LEU B 3151  1                                  31    
HELIX  392 BR5 LEU B 3160  TYR B 3168  1                                   9    
HELIX  393 BR6 PRO B 3175  THR B 3198  1                                  24    
HELIX  394 BR7 SER B 3228  MSE B 3240  1                                  13    
HELIX  395 BR8 ILE B 3243  ASN B 3250  1                                   8    
HELIX  396 BR9 PHE B 3252  LYS B 3267  1                                  16    
HELIX  397 BS1 THR B 3268  SER B 3288  1                                  21    
HELIX  398 BS2 GLU B 3295  LYS B 3302  1                                   8    
HELIX  399 BS3 LYS B 3318  TYR B 3334  1                                  17    
HELIX  400 BS4 GLU B 3344  ALA B 3346  5                                   3    
HELIX  401 BS5 CYS B 3347  ILE B 3359  1                                  13    
HELIX  402 BS6 ILE B 3374  GLN B 3379  1                                   6    
HELIX  403 BS7 ARG B 3380  GLU B 3395  1                                  16    
HELIX  404 BS8 ALA B 3396  GLY B 3404  1                                   9    
HELIX  405 BS9 GLY B 3408  ASN B 3430  1                                  23    
HELIX  406 BT1 SER B 3432  GLN B 3440  1                                   9    
HELIX  407 BT2 GLU B 3448  ALA B 3453  1                                   6    
HELIX  408 BT3 SER B 3458  ILE B 3472  1                                  15    
HELIX  409 BT4 GLU B 3477  VAL B 3490  1                                  14    
HELIX  410 BT5 PRO B 3491  ILE B 3496  5                                   6    
HELIX  411 BT6 TRP B 3498  LYS B 3508  1                                  11    
HELIX  412 BT7 HIS B 3516  TYR B 3525  1                                  10    
HELIX  413 BT8 VAL B 3530  TYR B 3540  1                                  11    
HELIX  414 BT9 GLY B 3548  LYS B 3561  1                                  14    
HELIX  415 BU1 GLY B 3566  ASP B 3576  1                                  11    
HELIX  416 BU2 ASN B 3580  ALA B 3594  1                                  15    
HELIX  417 BU3 LYS B 3603  GLY B 3618  1                                  16    
HELIX  418 BU4 ALA B 3622  ALA B 3627  1                                   6    
HELIX  419 BU5 ARG B 3630  THR B 3635  1                                   6    
HELIX  420 BU6 THR B 3635  ARG B 3653  1                                  19    
HELIX  421 BU7 ASP B 3658  ASP B 3673  1                                  16    
HELIX  422 BU8 GLU B 3682  SER B 3688  1                                   7    
HELIX  423 BU9 GLU B 3693  LEU B 3699  1                                   7    
HELIX  424 BV1 ASP B 3761  ASN B 3772  1                                  12    
HELIX  425 BV2 ASP B 3778  ARG B 3784  1                                   7    
HELIX  426 BV3 THR B 3811  GLU B 3824  1                                  14    
HELIX  427 BV4 CYS B 3837  LYS B 3845  1                                   9    
HELIX  428 BV5 GLY B 3861  MSE B 3890  1                                  30    
HELIX  429 BV6 SER B 3893  LEU B 3918  1                                  26    
HELIX  430 BV7 PHE B 3946  PHE B 3952  1                                   7    
HELIX  431 BV8 THR B 3964  MSE B 3971  1                                   8    
HELIX  432 BV9 GLU B 3976  SER B 3993  1                                  18    
HELIX  433 BW1 ASP B 3994  GLU B 4008  1                                  15    
HELIX  434 BW2 PRO B 4009  TRP B 4013  5                                   5    
HELIX  435 BW3 ASN B 4015  GLY B 4024  1                                  10    
HELIX  436 BW4 GLY B 4024  GLU B 4035  1                                  12    
HELIX  437 BW5 PRO B 4040  ALA B 4054  1                                  15    
HELIX  438 BW6 VAL B 4058  GLY B 4067  1                                  10    
HELIX  439 BW7 LYS B 4070  ALA B 4079  1                                  10    
HELIX  440 BW8 SER B 4084  ILE B 4089  1                                   6    
HELIX  441 BW9 GLU B 4101  MSE B 4108  1                                   8    
HELIX  442 BX1 ASP B 4113  THR B 4120  1                                   8    
HELIX  443 BX2 UNK S  102  UNK S  108  1                                   7    
HELIX  444 BX3 UNK S  116  UNK S  133  1                                  18    
HELIX  445 BX4 UNK S  213  UNK S  221  1                                   9    
SHEET    1 AA1 5 THR A3727  VAL A3728  0                                        
SHEET    2 AA1 5 LYS A3736  ILE A3740 -1  O  ARG A3737   N  THR A3727           
SHEET    3 AA1 5 HIS A3748  LYS A3753 -1  O  HIS A3748   N  ILE A3740           
SHEET    4 AA1 5 GLY A3801  GLU A3804 -1  O  GLY A3801   N  LYS A3753           
SHEET    5 AA1 5 VAL A3793  VAL A3794 -1  N  VAL A3794   O  LEU A3802           
SHEET    1 AA2 3 THR A3809  VAL A3810  0                                        
SHEET    2 AA2 3 PHE A3928  ALA A3931 -1  O  VAL A3930   N  VAL A3810           
SHEET    3 AA2 3 VAL A3937  GLY A3939 -1  O  ILE A3938   N  MSE A3929           
SHEET    1 AA3 5 THR B3727  VAL B3728  0                                        
SHEET    2 AA3 5 LYS B3736  ILE B3740 -1  O  ARG B3737   N  THR B3727           
SHEET    3 AA3 5 HIS B3748  LYS B3753 -1  O  HIS B3748   N  ILE B3740           
SHEET    4 AA3 5 GLY B3801  GLU B3804 -1  O  GLY B3801   N  LYS B3753           
SHEET    5 AA3 5 VAL B3793  VAL B3794 -1  N  VAL B3794   O  LEU B3802           
SHEET    1 AA4 3 THR B3809  VAL B3810  0                                        
SHEET    2 AA4 3 PHE B3928  ALA B3931 -1  O  VAL B3930   N  VAL B3810           
SHEET    3 AA4 3 VAL B3937  GLY B3939 -1  O  ILE B3938   N  MSE B3929           
LINK         C   LYS A  95                 N   MSE A  96     1555   1555  1.33  
LINK         C   MSE A  96                 N   GLY A  97     1555   1555  1.33  
LINK         C   LEU A 143                 N   MSE A 144     1555   1555  1.34  
LINK         C   MSE A 144                 N   ASP A 145     1555   1555  1.33  
LINK         C   GLU A 188                 N   MSE A 189     1555   1555  1.33  
LINK         C   MSE A 189                 N   ILE A 190     1555   1555  1.34  
LINK         C   GLN A 207                 N   MSE A 208     1555   1555  1.33  
LINK         C   MSE A 208                 N   THR A 209     1555   1555  1.34  
LINK         C   SER A 237                 N   MSE A 238     1555   1555  1.33  
LINK         C   MSE A 238                 N   GLU A 239     1555   1555  1.33  
LINK         C   ASN A 325                 N   MSE A 326     1555   1555  1.34  
LINK         C   MSE A 326                 N   VAL A 327     1555   1555  1.34  
LINK         C   GLU A 332                 N   MSE A 333     1555   1555  1.34  
LINK         C   MSE A 333                 N   HIS A 334     1555   1555  1.33  
LINK         C   PHE A 341                 N   MSE A 342     1555   1555  1.33  
LINK         C   MSE A 342                 N   GLU A 343     1555   1555  1.34  
LINK         C   PHE A 383                 N   MSE A 384     1555   1555  1.33  
LINK         C   MSE A 384                 N   TYR A 385     1555   1555  1.33  
LINK         C   GLN A 394                 N   MSE A 395     1555   1555  1.33  
LINK         C   MSE A 395                 N   PHE A 396     1555   1555  1.33  
LINK         C   GLN A 409                 N   MSE A 410     1555   1555  1.33  
LINK         C   MSE A 410                 N   PRO A 411     1555   1555  1.34  
LINK         C   VAL A 440                 N   MSE A 441     1555   1555  1.33  
LINK         C   MSE A 441                 N   GLN A 442     1555   1555  1.34  
LINK         C   LYS A 452                 N   MSE A 453     1555   1555  1.33  
LINK         C   MSE A 453                 N   GLN A 454     1555   1555  1.34  
LINK         C   GLN A 539                 N   MSE A 540     1555   1555  1.33  
LINK         C   MSE A 540                 N   MSE A 541     1555   1555  1.33  
LINK         C   MSE A 541                 N   ASP A 542     1555   1555  1.33  
LINK         C   TRP A 601                 N   MSE A 602     1555   1555  1.33  
LINK         C   MSE A 602                 N   ILE A 603     1555   1555  1.33  
LINK         C   LYS A 717                 N   MSE A 718     1555   1555  1.33  
LINK         C   MSE A 718                 N   LYS A 719     1555   1555  1.33  
LINK         C   GLN A 753                 N   MSE A 754     1555   1555  1.34  
LINK         C   MSE A 754                 N   ALA A 755     1555   1555  1.33  
LINK         C   VAL A 784                 N   MSE A 785     1555   1555  1.33  
LINK         C   MSE A 785                 N   GLN A 786     1555   1555  1.32  
LINK         C   GLN A 857                 N   MSE A 858     1555   1555  1.32  
LINK         C   MSE A 858                 N   LEU A 859     1555   1555  1.34  
LINK         C   GLU A 878                 N   MSE A 879     1555   1555  1.34  
LINK         C   MSE A 879                 N   MSE A 880     1555   1555  1.33  
LINK         C   MSE A 880                 N   LYS A 881     1555   1555  1.34  
LINK         C   GLU A 900                 N   MSE A 901     1555   1555  1.31  
LINK         C   MSE A 901                 N   LYS A 902     1555   1555  1.30  
LINK         C   SER A 936                 N   MSE A 937     1555   1555  1.32  
LINK         C   MSE A 937                 N   VAL A 938     1555   1555  1.34  
LINK         C   VAL A 938                 N   MSE A 939     1555   1555  1.33  
LINK         C   MSE A 939                 N   PHE A 940     1555   1555  1.33  
LINK         C   PHE A 940                 N   MSE A 941     1555   1555  1.33  
LINK         C   MSE A 941                 N   LEU A 942     1555   1555  1.34  
LINK         C   GLN A 947                 N   MSE A 948     1555   1555  1.33  
LINK         C   MSE A 948                 N   PRO A 949     1555   1555  1.35  
LINK         C   PRO A 957                 N   MSE A 958     1555   1555  1.33  
LINK         C   MSE A 958                 N   TYR A 959     1555   1555  1.33  
LINK         C   VAL A 988                 N   MSE A 989     1555   1555  1.33  
LINK         C   MSE A 989                 N   GLN A 990     1555   1555  1.33  
LINK         C   TYR A1107                 N   MSE A1108     1555   1555  1.32  
LINK         C   MSE A1108                 N   GLU A1109     1555   1555  1.34  
LINK         C   ALA A1302                 N   MSE A1303     1555   1555  1.32  
LINK         C   MSE A1303                 N   HIS A1304     1555   1555  1.34  
LINK         C   ILE A1341                 N   MSE A1342     1555   1555  1.34  
LINK         C   MSE A1342                 N   GLU A1343     1555   1555  1.33  
LINK         C   LEU A1368                 N   MSE A1369     1555   1555  1.33  
LINK         C   MSE A1369                 N   ARG A1370     1555   1555  1.34  
LINK         C   VAL A1391                 N   MSE A1392     1555   1555  1.33  
LINK         C   MSE A1392                 N   ALA A1393     1555   1555  1.33  
LINK         C   LEU A1402                 N   MSE A1403     1555   1555  1.33  
LINK         C   MSE A1403                 N   LYS A1404     1555   1555  1.33  
LINK         C   LYS A1407                 N   MSE A1408     1555   1555  1.33  
LINK         C   MSE A1408                 N   SER A1409     1555   1555  1.34  
LINK         C   LEU A1582                 N   MSE A1583     1555   1555  1.32  
LINK         C   MSE A1583                 N   GLN A1584     1555   1555  1.33  
LINK         C   LYS A1591                 N   MSE A1592     1555   1555  1.33  
LINK         C   MSE A1592                 N   VAL A1593     1555   1555  1.34  
LINK         C   GLY A1599                 N   MSE A1600     1555   1555  1.33  
LINK         C   MSE A1600                 N   LEU A1601     1555   1555  1.34  
LINK         C   LYS A1642                 N   MSE A1643     1555   1555  1.33  
LINK         C   MSE A1643                 N   ALA A1644     1555   1555  1.34  
LINK         C   PRO A1723                 N   MSE A1724     1555   1555  1.33  
LINK         C   MSE A1724                 N   GLN A1725     1555   1555  1.33  
LINK         C   CYS A1742                 N   MSE A1743     1555   1555  1.33  
LINK         C   MSE A1743                 N   LYS A1744     1555   1555  1.34  
LINK         C   PRO A1756                 N   MSE A1757     1555   1555  1.32  
LINK         C   MSE A1757                 N   LEU A1758     1555   1555  1.34  
LINK         C   LEU A1761                 N   MSE A1762     1555   1555  1.35  
LINK         C   MSE A1762                 N   THR A1763     1555   1555  1.32  
LINK         C   GLU A1803                 N   MSE A1804     1555   1555  1.35  
LINK         C   MSE A1804                 N   PHE A1805     1555   1555  1.34  
LINK         C   LYS A1870                 N   MSE A1871     1555   1555  1.32  
LINK         C   MSE A1871                 N   GLY A1872     1555   1555  1.33  
LINK         C   VAL A1879                 N   MSE A1880     1555   1555  1.32  
LINK         C   MSE A1880                 N   TYR A1881     1555   1555  1.34  
LINK         C   ASN A1926                 N   MSE A1927     1555   1555  1.33  
LINK         C   MSE A1927                 N   ALA A1928     1555   1555  1.34  
LINK         C   PRO A1997                 N   MSE A1998     1555   1555  1.33  
LINK         C   MSE A1998                 N   GLU A1999     1555   1555  1.33  
LINK         C   TYR A2024                 N   MSE A2025     1555   1555  1.33  
LINK         C   MSE A2025                 N   SER A2026     1555   1555  1.33  
LINK         C   GLU A2039                 N   MSE A2040     1555   1555  1.33  
LINK         C   MSE A2040                 N   SER A2041     1555   1555  1.33  
LINK         C   GLU A2084                 N   MSE A2085     1555   1555  1.33  
LINK         C   MSE A2085                 N   ASP A2086     1555   1555  1.33  
LINK         C   CYS A2093                 N   MSE A2094     1555   1555  1.32  
LINK         C   MSE A2094                 N   ALA A2095     1555   1555  1.33  
LINK         C   HIS A2103                 N   MSE A2104     1555   1555  1.33  
LINK         C   MSE A2104                 N   HIS A2105     1555   1555  1.33  
LINK         C   TRP A2125                 N   MSE A2126     1555   1555  1.33  
LINK         C   MSE A2126                 N   LYS A2127     1555   1555  1.34  
LINK         C   TYR A2184                 N   MSE A2185     1555   1555  1.33  
LINK         C   MSE A2185                 N   VAL A2186     1555   1555  1.33  
LINK         C   LEU A2219                 N   MSE A2220     1555   1555  1.32  
LINK         C   MSE A2220                 N   LYS A2221     1555   1555  1.34  
LINK         C   VAL A2280                 N   MSE A2281     1555   1555  1.33  
LINK         C   MSE A2281                 N   ALA A2282     1555   1555  1.34  
LINK         C   ASN A2306                 N   MSE A2307     1555   1555  1.33  
LINK         C   MSE A2307                 N   SER A2308     1555   1555  1.34  
LINK         C   VAL A2330                 N   MSE A2331     1555   1555  1.32  
LINK         C   MSE A2331                 N   GLU A2332     1555   1555  1.34  
LINK         C   THR A2355                 N   MSE A2356     1555   1555  1.33  
LINK         C   MSE A2356                 N   GLU A2357     1555   1555  1.33  
LINK         C   PHE A2378                 N   MSE A2379     1555   1555  1.33  
LINK         C   MSE A2379                 N   ASN A2380     1555   1555  1.33  
LINK         C   GLY A2407                 N   MSE A2408     1555   1555  1.33  
LINK         C   MSE A2408                 N   THR A2409     1555   1555  1.34  
LINK         C   VAL A2423                 N   MSE A2424     1555   1555  1.33  
LINK         C   MSE A2424                 N   ARG A2425     1555   1555  1.34  
LINK         C   LYS A2441                 N   MSE A2442     1555   1555  1.33  
LINK         C   MSE A2442                 N   MSE A2443     1555   1555  1.33  
LINK         C   MSE A2443                 N   PRO A2444     1555   1555  1.35  
LINK         C   GLN A2472                 N   MSE A2473     1555   1555  1.33  
LINK         C   MSE A2473                 N   TYR A2474     1555   1555  1.34  
LINK         C   LEU A2477                 N   MSE A2478     1555   1555  1.33  
LINK         C   MSE A2478                 N   TRP A2479     1555   1555  1.34  
LINK         C   GLU A2564                 N   MSE A2565     1555   1555  1.34  
LINK         C   MSE A2565                 N   THR A2566     1555   1555  1.34  
LINK         C   SER A2567                 N   MSE A2568     1555   1555  1.33  
LINK         C   MSE A2568                 N   SER A2569     1555   1555  1.32  
LINK         C   PRO A2575                 N   MSE A2576     1555   1555  1.33  
LINK         C   GLU A2819                 N   MSE A2820     1555   1555  1.32  
LINK         C   MSE A2820                 N   ASP A2821     1555   1555  1.34  
LINK         C   TYR A3043                 N   MSE A3044     1555   1555  1.34  
LINK         C   MSE A3044                 N   ILE A3045     1555   1555  1.33  
LINK         C   ALA A3068                 N   MSE A3069     1555   1555  1.33  
LINK         C   MSE A3069                 N   HIS A3070     1555   1555  1.34  
LINK         C   PHE A3110                 N   MSE A3111     1555   1555  1.33  
LINK         C   MSE A3111                 N   GLN A3112     1555   1555  1.34  
LINK         C   LYS A3172                 N   MSE A3173     1555   1555  1.33  
LINK         C   MSE A3173                 N   ASP A3174     1555   1555  1.31  
LINK         C   PRO A3175                 N   MSE A3176     1555   1555  1.33  
LINK         C   MSE A3176                 N   ASN A3177     1555   1555  1.34  
LINK         C   SER A3237                 N   MSE A3238     1555   1555  1.33  
LINK         C   MSE A3238                 N   LYS A3239     1555   1555  1.34  
LINK         C   LYS A3239                 N   MSE A3240     1555   1555  1.34  
LINK         C   MSE A3240                 N   LYS A3241     1555   1555  1.34  
LINK         C   LYS A3241                 N   MSE A3242     1555   1555  1.33  
LINK         C   MSE A3242                 N   ILE A3243     1555   1555  1.34  
LINK         C   ALA A3255                 N   MSE A3256     1555   1555  1.33  
LINK         C   MSE A3256                 N   LYS A3257     1555   1555  1.34  
LINK         C   TYR A3413                 N   MSE A3414     1555   1555  1.34  
LINK         C   MSE A3414                 N   THR A3415     1555   1555  1.33  
LINK         C   LYS A3449                 N   MSE A3450     1555   1555  1.34  
LINK         C   MSE A3450                 N   LEU A3451     1555   1555  1.33  
LINK         C   LEU A3482                 N   MSE A3483     1555   1555  1.32  
LINK         C   MSE A3483                 N   THR A3484     1555   1555  1.34  
LINK         C   HIS A3501                 N   MSE A3502     1555   1555  1.33  
LINK         C   MSE A3502                 N   VAL A3503     1555   1555  1.33  
LINK         C   LYS A3608                 N   MSE A3609     1555   1555  1.33  
LINK         C   MSE A3609                 N   TYR A3610     1555   1555  1.34  
LINK         C   ARG A3612                 N   MSE A3613     1555   1555  1.31  
LINK         C   MSE A3613                 N   TYR A3614     1555   1555  1.35  
LINK         C   ARG A3653                 N   MSE A3654     1555   1555  1.34  
LINK         C   MSE A3654                 N   LYS A3655     1555   1555  1.34  
LINK         C   ASN A3664                 N   MSE A3665     1555   1555  1.34  
LINK         C   MSE A3665                 N   LEU A3666     1555   1555  1.33  
LINK         C   LYS A3669                 N   MSE A3670     1555   1555  1.33  
LINK         C   MSE A3670                 N   ASN A3671     1555   1555  1.34  
LINK         C   TRP A3686                 N   MSE A3687     1555   1555  1.33  
LINK         C   MSE A3687                 N   SER A3688     1555   1555  1.34  
LINK         C   VAL A3728                 N   MSE A3729     1555   1555  1.33  
LINK         C   MSE A3729                 N   ALA A3730     1555   1555  1.34  
LINK         C   VAL A3770                 N   MSE A3771     1555   1555  1.34  
LINK         C   MSE A3771                 N   ASN A3772     1555   1555  1.34  
LINK         C   PRO A3795                 N   MSE A3796     1555   1555  1.33  
LINK         C   MSE A3796                 N   THR A3797     1555   1555  1.34  
LINK         C   THR A3819                 N   MSE A3820     1555   1555  1.33  
LINK         C   MSE A3820                 N   SER A3821     1555   1555  1.34  
LINK         C   LYS A3845                 N   MSE A3846     1555   1555  1.33  
LINK         C   MSE A3846                 N   SER A3847     1555   1555  1.34  
LINK         C   TYR A3855                 N   MSE A3856     1555   1555  1.33  
LINK         C   MSE A3856                 N   LEU A3857     1555   1555  1.34  
LINK         C   LEU A3857                 N   MSE A3858     1555   1555  1.33  
LINK         C   MSE A3858                 N   TYR A3859     1555   1555  1.35  
LINK         C   ARG A3889                 N   MSE A3890     1555   1555  1.33  
LINK         C   MSE A3890                 N   SER A3891     1555   1555  1.33  
LINK         C   PHE A3928                 N   MSE A3929     1555   1555  1.34  
LINK         C   MSE A3929                 N   VAL A3930     1555   1555  1.32  
LINK         C   ALA A3931                 N   MSE A3932     1555   1555  1.33  
LINK         C   MSE A3932                 N   GLU A3933     1555   1555  1.34  
LINK         C   LEU A3958                 N   MSE A3959     1555   1555  1.34  
LINK         C   MSE A3959                 N   PRO A3960     1555   1555  1.34  
LINK         C   LEU A3970                 N   MSE A3971     1555   1555  1.33  
LINK         C   MSE A3971                 N   LEU A3972     1555   1555  1.32  
LINK         C   PRO A3973                 N   MSE A3974     1555   1555  1.34  
LINK         C   MSE A3974                 N   LYS A3975     1555   1555  1.35  
LINK         C   LEU A3979                 N   MSE A3980     1555   1555  1.33  
LINK         C   MSE A3980                 N   TYR A3981     1555   1555  1.33  
LINK         C   ILE A3983                 N   MSE A3984     1555   1555  1.33  
LINK         C   MSE A3984                 N   VAL A3985     1555   1555  1.34  
LINK         C   THR A4001                 N   MSE A4002     1555   1555  1.32  
LINK         C   MSE A4002                 N   ASP A4003     1555   1555  1.34  
LINK         C   LYS A4019                 N   MSE A4020     1555   1555  1.32  
LINK         C   MSE A4020                 N   LEU A4021     1555   1555  1.34  
LINK         C   LEU A4107                 N   MSE A4108     1555   1555  1.33  
LINK         C   MSE A4108                 N   ASP A4109     1555   1555  1.34  
LINK         C   TRP A4127                 N   MSE A4128     1555   1555  1.33  
LINK         C   UNK K 219                 N   MSE K 220     1555   1555  1.33  
LINK         C   MSE K 220                 N   UNK K 221     1555   1555  1.33  
LINK         C   LYS B  95                 N   MSE B  96     1555   1555  1.33  
LINK         C   MSE B  96                 N   GLY B  97     1555   1555  1.33  
LINK         C   LEU B 143                 N   MSE B 144     1555   1555  1.34  
LINK         C   MSE B 144                 N   ASP B 145     1555   1555  1.35  
LINK         C   GLU B 188                 N   MSE B 189     1555   1555  1.32  
LINK         C   MSE B 189                 N   ILE B 190     1555   1555  1.34  
LINK         C   GLN B 207                 N   MSE B 208     1555   1555  1.34  
LINK         C   MSE B 208                 N   THR B 209     1555   1555  1.33  
LINK         C   SER B 237                 N   MSE B 238     1555   1555  1.33  
LINK         C   MSE B 238                 N   GLU B 239     1555   1555  1.34  
LINK         C   ASN B 325                 N   MSE B 326     1555   1555  1.33  
LINK         C   MSE B 326                 N   VAL B 327     1555   1555  1.33  
LINK         C   GLU B 332                 N   MSE B 333     1555   1555  1.33  
LINK         C   MSE B 333                 N   HIS B 334     1555   1555  1.33  
LINK         C   PHE B 341                 N   MSE B 342     1555   1555  1.34  
LINK         C   MSE B 342                 N   GLU B 343     1555   1555  1.34  
LINK         C   PHE B 383                 N   MSE B 384     1555   1555  1.33  
LINK         C   MSE B 384                 N   TYR B 385     1555   1555  1.33  
LINK         C   GLN B 394                 N   MSE B 395     1555   1555  1.32  
LINK         C   MSE B 395                 N   PHE B 396     1555   1555  1.33  
LINK         C   GLN B 409                 N   MSE B 410     1555   1555  1.33  
LINK         C   MSE B 410                 N   PRO B 411     1555   1555  1.36  
LINK         C   VAL B 440                 N   MSE B 441     1555   1555  1.32  
LINK         C   MSE B 441                 N   GLN B 442     1555   1555  1.34  
LINK         C   LYS B 452                 N   MSE B 453     1555   1555  1.33  
LINK         C   MSE B 453                 N   GLN B 454     1555   1555  1.33  
LINK         C   GLN B 539                 N   MSE B 540     1555   1555  1.33  
LINK         C   MSE B 540                 N   MSE B 541     1555   1555  1.33  
LINK         C   MSE B 541                 N   ASP B 542     1555   1555  1.34  
LINK         C   TRP B 601                 N   MSE B 602     1555   1555  1.33  
LINK         C   MSE B 602                 N   ILE B 603     1555   1555  1.33  
LINK         C   LYS B 717                 N   MSE B 718     1555   1555  1.33  
LINK         C   MSE B 718                 N   LYS B 719     1555   1555  1.34  
LINK         C   GLN B 753                 N   MSE B 754     1555   1555  1.33  
LINK         C   MSE B 754                 N   ALA B 755     1555   1555  1.34  
LINK         C   VAL B 784                 N   MSE B 785     1555   1555  1.33  
LINK         C   MSE B 785                 N   GLN B 786     1555   1555  1.34  
LINK         C   GLN B 857                 N   MSE B 858     1555   1555  1.33  
LINK         C   MSE B 858                 N   LEU B 859     1555   1555  1.34  
LINK         C   GLU B 878                 N   MSE B 879     1555   1555  1.33  
LINK         C   MSE B 879                 N   MSE B 880     1555   1555  1.33  
LINK         C   MSE B 880                 N   LYS B 881     1555   1555  1.32  
LINK         C   GLU B 900                 N   MSE B 901     1555   1555  1.33  
LINK         C   MSE B 901                 N   LYS B 902     1555   1555  1.34  
LINK         C   SER B 936                 N   MSE B 937     1555   1555  1.32  
LINK         C   MSE B 937                 N   VAL B 938     1555   1555  1.33  
LINK         C   VAL B 938                 N   MSE B 939     1555   1555  1.32  
LINK         C   MSE B 939                 N   PHE B 940     1555   1555  1.34  
LINK         C   PHE B 940                 N   MSE B 941     1555   1555  1.34  
LINK         C   MSE B 941                 N   LEU B 942     1555   1555  1.33  
LINK         C   GLN B 947                 N   MSE B 948     1555   1555  1.33  
LINK         C   MSE B 948                 N   PRO B 949     1555   1555  1.34  
LINK         C   PRO B 957                 N   MSE B 958     1555   1555  1.33  
LINK         C   MSE B 958                 N   TYR B 959     1555   1555  1.33  
LINK         C   VAL B 988                 N   MSE B 989     1555   1555  1.35  
LINK         C   MSE B 989                 N   GLN B 990     1555   1555  1.32  
LINK         C   TYR B1107                 N   MSE B1108     1555   1555  1.33  
LINK         C   MSE B1108                 N   GLU B1109     1555   1555  1.34  
LINK         C   ALA B1302                 N   MSE B1303     1555   1555  1.33  
LINK         C   MSE B1303                 N   HIS B1304     1555   1555  1.35  
LINK         C   ILE B1341                 N   MSE B1342     1555   1555  1.32  
LINK         C   MSE B1342                 N   GLU B1343     1555   1555  1.33  
LINK         C   LEU B1368                 N   MSE B1369     1555   1555  1.33  
LINK         C   MSE B1369                 N   ARG B1370     1555   1555  1.33  
LINK         C   VAL B1391                 N   MSE B1392     1555   1555  1.34  
LINK         C   MSE B1392                 N   ALA B1393     1555   1555  1.33  
LINK         C   LEU B1402                 N   MSE B1403     1555   1555  1.32  
LINK         C   MSE B1403                 N   LYS B1404     1555   1555  1.34  
LINK         C   LYS B1407                 N   MSE B1408     1555   1555  1.33  
LINK         C   MSE B1408                 N   SER B1409     1555   1555  1.33  
LINK         C   LEU B1582                 N   MSE B1583     1555   1555  1.32  
LINK         C   MSE B1583                 N   GLN B1584     1555   1555  1.34  
LINK         C   LYS B1591                 N   MSE B1592     1555   1555  1.33  
LINK         C   MSE B1592                 N   VAL B1593     1555   1555  1.33  
LINK         C   GLY B1599                 N   MSE B1600     1555   1555  1.33  
LINK         C   MSE B1600                 N   LEU B1601     1555   1555  1.33  
LINK         C   LYS B1642                 N   MSE B1643     1555   1555  1.32  
LINK         C   MSE B1643                 N   ALA B1644     1555   1555  1.35  
LINK         C   PRO B1723                 N   MSE B1724     1555   1555  1.33  
LINK         C   MSE B1724                 N   GLN B1725     1555   1555  1.33  
LINK         C   CYS B1742                 N   MSE B1743     1555   1555  1.32  
LINK         C   MSE B1743                 N   LYS B1744     1555   1555  1.34  
LINK         C   PRO B1756                 N   MSE B1757     1555   1555  1.32  
LINK         C   MSE B1757                 N   LEU B1758     1555   1555  1.34  
LINK         C   LEU B1761                 N   MSE B1762     1555   1555  1.34  
LINK         C   MSE B1762                 N   THR B1763     1555   1555  1.33  
LINK         C   GLU B1803                 N   MSE B1804     1555   1555  1.34  
LINK         C   MSE B1804                 N   PHE B1805     1555   1555  1.34  
LINK         C   LYS B1870                 N   MSE B1871     1555   1555  1.32  
LINK         C   MSE B1871                 N   GLY B1872     1555   1555  1.33  
LINK         C   VAL B1879                 N   MSE B1880     1555   1555  1.33  
LINK         C   MSE B1880                 N   TYR B1881     1555   1555  1.33  
LINK         C   ASN B1926                 N   MSE B1927     1555   1555  1.32  
LINK         C   MSE B1927                 N   ALA B1928     1555   1555  1.34  
LINK         C   PRO B1997                 N   MSE B1998     1555   1555  1.33  
LINK         C   MSE B1998                 N   GLU B1999     1555   1555  1.33  
LINK         C   TYR B2024                 N   MSE B2025     1555   1555  1.33  
LINK         C   MSE B2025                 N   SER B2026     1555   1555  1.34  
LINK         C   GLU B2039                 N   MSE B2040     1555   1555  1.33  
LINK         C   MSE B2040                 N   SER B2041     1555   1555  1.34  
LINK         C   GLU B2084                 N   MSE B2085     1555   1555  1.33  
LINK         C   MSE B2085                 N   ASP B2086     1555   1555  1.33  
LINK         C   CYS B2093                 N   MSE B2094     1555   1555  1.33  
LINK         C   MSE B2094                 N   ALA B2095     1555   1555  1.33  
LINK         C   HIS B2103                 N   MSE B2104     1555   1555  1.33  
LINK         C   MSE B2104                 N   HIS B2105     1555   1555  1.33  
LINK         C   TRP B2125                 N   MSE B2126     1555   1555  1.32  
LINK         C   MSE B2126                 N   LYS B2127     1555   1555  1.34  
LINK         C   TYR B2184                 N   MSE B2185     1555   1555  1.34  
LINK         C   MSE B2185                 N   VAL B2186     1555   1555  1.34  
LINK         C   LEU B2219                 N   MSE B2220     1555   1555  1.31  
LINK         C   MSE B2220                 N   LYS B2221     1555   1555  1.35  
LINK         C   VAL B2280                 N   MSE B2281     1555   1555  1.33  
LINK         C   MSE B2281                 N   ALA B2282     1555   1555  1.33  
LINK         C   ASN B2306                 N   MSE B2307     1555   1555  1.34  
LINK         C   MSE B2307                 N   SER B2308     1555   1555  1.35  
LINK         C   VAL B2330                 N   MSE B2331     1555   1555  1.32  
LINK         C   MSE B2331                 N   GLU B2332     1555   1555  1.34  
LINK         C   THR B2355                 N   MSE B2356     1555   1555  1.34  
LINK         C   MSE B2356                 N   GLU B2357     1555   1555  1.33  
LINK         C   PHE B2378                 N   MSE B2379     1555   1555  1.34  
LINK         C   MSE B2379                 N   ASN B2380     1555   1555  1.33  
LINK         C   GLY B2407                 N   MSE B2408     1555   1555  1.32  
LINK         C   MSE B2408                 N   THR B2409     1555   1555  1.33  
LINK         C   VAL B2423                 N   MSE B2424     1555   1555  1.34  
LINK         C   MSE B2424                 N   ARG B2425     1555   1555  1.33  
LINK         C   LYS B2441                 N   MSE B2442     1555   1555  1.34  
LINK         C   MSE B2442                 N   MSE B2443     1555   1555  1.32  
LINK         C   MSE B2443                 N   PRO B2444     1555   1555  1.35  
LINK         C   GLN B2472                 N   MSE B2473     1555   1555  1.32  
LINK         C   MSE B2473                 N   TYR B2474     1555   1555  1.34  
LINK         C   LEU B2477                 N   MSE B2478     1555   1555  1.32  
LINK         C   MSE B2478                 N   TRP B2479     1555   1555  1.34  
LINK         C   GLU B2564                 N   MSE B2565     1555   1555  1.33  
LINK         C   MSE B2565                 N   THR B2566     1555   1555  1.34  
LINK         C   SER B2567                 N   MSE B2568     1555   1555  1.33  
LINK         C   MSE B2568                 N   SER B2569     1555   1555  1.33  
LINK         C   PRO B2575                 N   MSE B2576     1555   1555  1.33  
LINK         C   GLU B2819                 N   MSE B2820     1555   1555  1.32  
LINK         C   MSE B2820                 N   ASP B2821     1555   1555  1.34  
LINK         C   TYR B3043                 N   MSE B3044     1555   1555  1.33  
LINK         C   MSE B3044                 N   ILE B3045     1555   1555  1.34  
LINK         C   ALA B3068                 N   MSE B3069     1555   1555  1.33  
LINK         C   MSE B3069                 N   HIS B3070     1555   1555  1.33  
LINK         C   PHE B3110                 N   MSE B3111     1555   1555  1.33  
LINK         C   MSE B3111                 N   GLN B3112     1555   1555  1.33  
LINK         C   LYS B3172                 N   MSE B3173     1555   1555  1.32  
LINK         C   MSE B3173                 N   ASP B3174     1555   1555  1.33  
LINK         C   PRO B3175                 N   MSE B3176     1555   1555  1.34  
LINK         C   MSE B3176                 N   ASN B3177     1555   1555  1.34  
LINK         C   SER B3237                 N   MSE B3238     1555   1555  1.33  
LINK         C   MSE B3238                 N   LYS B3239     1555   1555  1.34  
LINK         C   LYS B3239                 N   MSE B3240     1555   1555  1.34  
LINK         C   MSE B3240                 N   LYS B3241     1555   1555  1.34  
LINK         C   LYS B3241                 N   MSE B3242     1555   1555  1.33  
LINK         C   MSE B3242                 N   ILE B3243     1555   1555  1.32  
LINK         C   ALA B3255                 N   MSE B3256     1555   1555  1.33  
LINK         C   MSE B3256                 N   LYS B3257     1555   1555  1.34  
LINK         C   TYR B3413                 N   MSE B3414     1555   1555  1.34  
LINK         C   MSE B3414                 N   THR B3415     1555   1555  1.33  
LINK         C   LYS B3449                 N   MSE B3450     1555   1555  1.32  
LINK         C   MSE B3450                 N   LEU B3451     1555   1555  1.33  
LINK         C   LEU B3482                 N   MSE B3483     1555   1555  1.33  
LINK         C   MSE B3483                 N   THR B3484     1555   1555  1.34  
LINK         C   HIS B3501                 N   MSE B3502     1555   1555  1.34  
LINK         C   MSE B3502                 N   VAL B3503     1555   1555  1.33  
LINK         C   LYS B3608                 N   MSE B3609     1555   1555  1.33  
LINK         C   MSE B3609                 N   TYR B3610     1555   1555  1.34  
LINK         C   ARG B3612                 N   MSE B3613     1555   1555  1.33  
LINK         C   MSE B3613                 N   TYR B3614     1555   1555  1.34  
LINK         C   ARG B3653                 N   MSE B3654     1555   1555  1.34  
LINK         C   MSE B3654                 N   LYS B3655     1555   1555  1.33  
LINK         C   ASN B3664                 N   MSE B3665     1555   1555  1.33  
LINK         C   MSE B3665                 N   LEU B3666     1555   1555  1.34  
LINK         C   LYS B3669                 N   MSE B3670     1555   1555  1.33  
LINK         C   MSE B3670                 N   ASN B3671     1555   1555  1.33  
LINK         C   TRP B3686                 N   MSE B3687     1555   1555  1.33  
LINK         C   MSE B3687                 N   SER B3688     1555   1555  1.34  
LINK         C   VAL B3728                 N   MSE B3729     1555   1555  1.33  
LINK         C   MSE B3729                 N   ALA B3730     1555   1555  1.33  
LINK         C   VAL B3770                 N   MSE B3771     1555   1555  1.33  
LINK         C   MSE B3771                 N   ASN B3772     1555   1555  1.34  
LINK         C   PRO B3795                 N   MSE B3796     1555   1555  1.32  
LINK         C   MSE B3796                 N   THR B3797     1555   1555  1.33  
LINK         C   THR B3819                 N   MSE B3820     1555   1555  1.33  
LINK         C   MSE B3820                 N   SER B3821     1555   1555  1.33  
LINK         C   LYS B3845                 N   MSE B3846     1555   1555  1.33  
LINK         C   MSE B3846                 N   SER B3847     1555   1555  1.34  
LINK         C   TYR B3855                 N   MSE B3856     1555   1555  1.33  
LINK         C   MSE B3856                 N   LEU B3857     1555   1555  1.33  
LINK         C   LEU B3857                 N   MSE B3858     1555   1555  1.32  
LINK         C   MSE B3858                 N   TYR B3859     1555   1555  1.33  
LINK         C   ARG B3889                 N   MSE B3890     1555   1555  1.33  
LINK         C   MSE B3890                 N   SER B3891     1555   1555  1.34  
LINK         C   PHE B3928                 N   MSE B3929     1555   1555  1.32  
LINK         C   MSE B3929                 N   VAL B3930     1555   1555  1.33  
LINK         C   ALA B3931                 N   MSE B3932     1555   1555  1.33  
LINK         C   MSE B3932                 N   GLU B3933     1555   1555  1.33  
LINK         C   LEU B3958                 N   MSE B3959     1555   1555  1.33  
LINK         C   MSE B3959                 N   PRO B3960     1555   1555  1.33  
LINK         C   LEU B3970                 N   MSE B3971     1555   1555  1.33  
LINK         C   MSE B3971                 N   LEU B3972     1555   1555  1.33  
LINK         C   PRO B3973                 N   MSE B3974     1555   1555  1.33  
LINK         C   MSE B3974                 N   LYS B3975     1555   1555  1.35  
LINK         C   LEU B3979                 N   MSE B3980     1555   1555  1.34  
LINK         C   MSE B3980                 N   TYR B3981     1555   1555  1.33  
LINK         C   ILE B3983                 N   MSE B3984     1555   1555  1.33  
LINK         C   MSE B3984                 N   VAL B3985     1555   1555  1.34  
LINK         C   THR B4001                 N   MSE B4002     1555   1555  1.33  
LINK         C   MSE B4002                 N   ASP B4003     1555   1555  1.33  
LINK         C   LYS B4019                 N   MSE B4020     1555   1555  1.33  
LINK         C   MSE B4020                 N   LEU B4021     1555   1555  1.33  
LINK         C   LEU B4107                 N   MSE B4108     1555   1555  1.33  
LINK         C   MSE B4108                 N   ASP B4109     1555   1555  1.34  
LINK         C   TRP B4127                 N   MSE B4128     1555   1555  1.33  
LINK         C   UNK S 219                 N   MSE S 220     1555   1555  1.33  
LINK         C   MSE S 220                 N   UNK S 221     1555   1555  1.33  
CISPEP   1 SER A  492    LYS A  493          0        -1.19                     
CISPEP   2 LEU A 1975    LEU A 1976          0        10.29                     
CISPEP   3 PHE A 2066    ARG A 2067          0         7.98                     
CISPEP   4 GLU A 2070    GLN A 2071          0        -4.76                     
CISPEP   5 ASN A 2152    THR A 2153          0         2.90                     
CISPEP   6 LEU A 3151    SER A 3152          0        -8.31                     
CISPEP   7 SER A 3152    SER A 3153          0       -17.71                     
CISPEP   8 SER A 3314    TYR A 3315          0         3.04                     
CISPEP   9 LEU A 3578    SER A 3579          0         1.27                     
CISPEP  10 MSE A 3974    LYS A 3975          0        26.53                     
CISPEP  11 GLU A 4069    LYS A 4070          0        -1.84                     
CISPEP  12 SER B  492    LYS B  493          0         5.27                     
CISPEP  13 LEU B 1975    LEU B 1976          0         4.78                     
CISPEP  14 PHE B 2066    ARG B 2067          0        11.60                     
CISPEP  15 GLU B 2070    GLN B 2071          0        -8.31                     
CISPEP  16 ASN B 2152    THR B 2153          0         7.36                     
CISPEP  17 LEU B 3151    SER B 3152          0        -5.87                     
CISPEP  18 SER B 3152    SER B 3153          0       -14.15                     
CISPEP  19 SER B 3314    TYR B 3315          0         3.76                     
CISPEP  20 LEU B 3578    SER B 3579          0        -0.23                     
CISPEP  21 MSE B 3974    LYS B 3975          0        18.68                     
CISPEP  22 GLU B 4069    LYS B 4070          0        -2.20                     
CRYST1  169.120  132.640  296.590  90.00 105.53  90.00 P 1 21 1      4          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.005913  0.000000  0.001643        0.00000                         
SCALE2      0.000000  0.007539  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.003499        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system