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Database: PDB
Entry: 5M52
LinkDB: 5M52
Original site: 5M52 
HEADER    HYDROLASE                               20-OCT-16   5M52              
TITLE     CRYSTAL STRUCTURE OF YEAST BRR2 FULL-LENGHT IN COMPLEX WITH PRP8 JAB1 
TITLE    2 DOMAIN                                                               
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PRE-MRNA-SPLICING HELICASE BRR2;                           
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: PROTEIN SNU246, YEAST BRR2;                                 
COMPND   5 EC: 3.6.4.13;                                                        
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: PRE-MRNA-SPLICING FACTOR 8;                                
COMPND   9 CHAIN: C, D;                                                         
COMPND  10 SYNONYM: YEAST PRP8 JAB1 DOMAIN;                                     
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   3 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   4 ORGANISM_TAXID: 4932;                                                
SOURCE   5 GENE: BRR2, RSS1, SNU246, YER172C, SYGP-ORF66;                       
SOURCE   6 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE   7 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  11 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  12 ORGANISM_TAXID: 4932;                                                
SOURCE  13 GENE: PRP8, DBF3, DNA39, RNA8, SLT21, USA2, YHR165C;                 
SOURCE  14 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  15 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    PROTEIN COMPLEX, HELICASE, HYDROLASE                                  
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    J.WOLLENHAUPT,E.ABSMEIER,C.BECKE,K.F.SANTOS,M.C.WAHL                  
REVDAT   3   25-JAN-17 5M52    1       JRNL                                     
REVDAT   2   11-JAN-17 5M52    1       JRNL                                     
REVDAT   1   07-DEC-16 5M52    0                                                
JRNL        AUTH   E.ABSMEIER,C.BECKE,J.WOLLENHAUPT,K.F.SANTOS,M.C.WAHL         
JRNL        TITL   INTERPLAY OF CIS- AND TRANS-REGULATORY MECHANISMS IN THE     
JRNL        TITL 2 SPLICEOSOMAL RNA HELICASE BRR2.                              
JRNL        REF    CELL CYCLE                    V.  16   100 2017              
JRNL        REFN                   ESSN 1551-4005                               
JRNL        PMID   27880071                                                     
JRNL        DOI    10.1080/15384101.2016.1255384                                
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.40 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.8.0124                                      
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON                               
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.40                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.72                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.6                           
REMARK   3   NUMBER OF REFLECTIONS             : 92351                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.253                           
REMARK   3   R VALUE            (WORKING SET) : 0.252                           
REMARK   3   FREE R VALUE                     : 0.296                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 2.200                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 2100                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 3.40                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 3.49                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 6480                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 96.20                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.3730                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 147                          
REMARK   3   BIN FREE R VALUE                    : 0.3800                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 34512                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 10                                      
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 94.29                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 1.73000                                              
REMARK   3    B22 (A**2) : -3.18000                                             
REMARK   3    B33 (A**2) : 1.45000                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): NULL          
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.621         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.564         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 38.530        
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.897                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.844                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 35241 ; 0.007 ; 0.019       
REMARK   3   BOND LENGTHS OTHERS               (A): 33819 ; 0.001 ; 0.020       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 47767 ; 0.937 ; 1.964       
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 77982 ; 0.821 ; 3.000       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  4289 ; 4.797 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):  1637 ;34.413 ;24.979       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  6313 ;12.201 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   157 ;10.296 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  5421 ; 0.053 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 39492 ; 0.003 ; 0.021       
REMARK   3   GENERAL PLANES OTHERS             (A):  7909 ; 0.001 ; 0.020       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2): 17207 ; 1.295 ; 9.525       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2): 17206 ; 1.295 ; 9.525       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 21479 ; 2.411 ;14.279       
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2): 21480 ; 2.411 ;14.279       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2): 18034 ; 0.687 ; 9.525       
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2): 18033 ; 0.687 ; 9.525       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2): 26288 ; 1.425 ;14.258       
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2): 38844 ; 4.035 ;74.117       
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2): 38845 ; 4.035 ;74.117       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL                              
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : NULL                                                 
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 5M52 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 20-OCT-16.                  
REMARK 100 THE DEPOSITION ID IS D_1200001956.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 06-SEP-15                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : BESSY                              
REMARK 200  BEAMLINE                       : 14.1                               
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9184                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M                 
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XDS                                
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 94451                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.400                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.6                               
REMARK 200  DATA REDUNDANCY                : 6.750                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : 0.32700                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 7.1000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.40                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.60                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : 1.56000                            
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 5DCA                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 60.12                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.08                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M TRIS-HCL PH 7.5, 10.5 % (W/V)      
REMARK 280  PEG 3350, 0.2 M MGCL, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE    
REMARK 280  291.15K                                                             
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X+1/2,-Y,Z+1/2                                         
REMARK 290       3555   -X,Y+1/2,-Z+1/2                                         
REMARK 290       4555   X+1/2,-Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       89.66750            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      105.17400            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       90.57900            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      105.17400            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       89.66750            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       90.57900            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5450 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 97750 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -22.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5300 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 94980 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -23.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, D                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     THR A     2                                                      
REMARK 465     GLU A     3                                                      
REMARK 465     HIS A     4                                                      
REMARK 465     GLU A     5                                                      
REMARK 465     THR A     6                                                      
REMARK 465     LYS A     7                                                      
REMARK 465     ASP A     8                                                      
REMARK 465     LYS A     9                                                      
REMARK 465     ALA A    10                                                      
REMARK 465     LYS A    11                                                      
REMARK 465     LYS A    12                                                      
REMARK 465     ILE A    13                                                      
REMARK 465     ARG A    14                                                      
REMARK 465     GLU A    15                                                      
REMARK 465     ILE A    16                                                      
REMARK 465     TYR A    17                                                      
REMARK 465     ARG A    18                                                      
REMARK 465     TYR A    19                                                      
REMARK 465     ASP A    20                                                      
REMARK 465     GLU A    21                                                      
REMARK 465     MET A    22                                                      
REMARK 465     SER A    23                                                      
REMARK 465     ASN A    24                                                      
REMARK 465     LYS A    25                                                      
REMARK 465     VAL A    26                                                      
REMARK 465     LEU A    27                                                      
REMARK 465     LYS A    28                                                      
REMARK 465     VAL A    29                                                      
REMARK 465     ASP A    30                                                      
REMARK 465     LYS A    31                                                      
REMARK 465     ARG A    32                                                      
REMARK 465     PHE A    33                                                      
REMARK 465     MET A    34                                                      
REMARK 465     ASN A    35                                                      
REMARK 465     THR A    36                                                      
REMARK 465     SER A    37                                                      
REMARK 465     GLN A    38                                                      
REMARK 465     ASN A    39                                                      
REMARK 465     PRO A    40                                                      
REMARK 465     GLN A    41                                                      
REMARK 465     ARG A    42                                                      
REMARK 465     ASP A    43                                                      
REMARK 465     ALA A    44                                                      
REMARK 465     GLU A    45                                                      
REMARK 465     ILE A    46                                                      
REMARK 465     SER A    47                                                      
REMARK 465     GLN A    48                                                      
REMARK 465     PRO A    49                                                      
REMARK 465     LYS A    50                                                      
REMARK 465     SER A    51                                                      
REMARK 465     MET A    52                                                      
REMARK 465     SER A    53                                                      
REMARK 465     GLY A    54                                                      
REMARK 465     ARG A    55                                                      
REMARK 465     ILE A    56                                                      
REMARK 465     SER A    57                                                      
REMARK 465     ALA A    58                                                      
REMARK 465     LYS A    59                                                      
REMARK 465     ASP A    60                                                      
REMARK 465     MET A    61                                                      
REMARK 465     GLY A    62                                                      
REMARK 465     GLN A    63                                                      
REMARK 465     GLY A    64                                                      
REMARK 465     LEU A    65                                                      
REMARK 465     CYS A    66                                                      
REMARK 465     ASN A    67                                                      
REMARK 465     ASN A    68                                                      
REMARK 465     ILE A    69                                                      
REMARK 465     ASN A    70                                                      
REMARK 465     LYS A    71                                                      
REMARK 465     GLY A    72                                                      
REMARK 465     LEU A    73                                                      
REMARK 465     LYS A    74                                                      
REMARK 465     GLU A    75                                                      
REMARK 465     ASN A    76                                                      
REMARK 465     ASP A    77                                                      
REMARK 465     VAL A    78                                                      
REMARK 465     ALA A    79                                                      
REMARK 465     VAL A    80                                                      
REMARK 465     GLU A    81                                                      
REMARK 465     LYS A    82                                                      
REMARK 465     THR A    83                                                      
REMARK 465     GLY A    84                                                      
REMARK 465     LYS A    85                                                      
REMARK 465     SER A    86                                                      
REMARK 465     ALA A    87                                                      
REMARK 465     SER A    88                                                      
REMARK 465     LEU A    89                                                      
REMARK 465     LYS A    90                                                      
REMARK 465     LYS A    91                                                      
REMARK 465     ILE A    92                                                      
REMARK 465     GLN A    93                                                      
REMARK 465     GLN A    94                                                      
REMARK 465     HIS A    95                                                      
REMARK 465     ASN A    96                                                      
REMARK 465     THR A    97                                                      
REMARK 465     ILE A    98                                                      
REMARK 465     LEU A    99                                                      
REMARK 465     ASN A   100                                                      
REMARK 465     SER A   101                                                      
REMARK 465     SER A   102                                                      
REMARK 465     SER A   103                                                      
REMARK 465     ASP A   104                                                      
REMARK 465     PHE A   105                                                      
REMARK 465     ARG A   106                                                      
REMARK 465     LEU A   107                                                      
REMARK 465     HIS A   108                                                      
REMARK 465     TYR A   109                                                      
REMARK 465     TYR A   110                                                      
REMARK 465     PRO A   111                                                      
REMARK 465     LYS A   112                                                      
REMARK 465     ASP A   113                                                      
REMARK 465     GLU A   155                                                      
REMARK 465     GLU A   156                                                      
REMARK 465     ASN A   157                                                      
REMARK 465     GLU A   158                                                      
REMARK 465     ASP A   159                                                      
REMARK 465     GLY A   160                                                      
REMARK 465     ASN A   161                                                      
REMARK 465     ILE A   162                                                      
REMARK 465     GLU A   163                                                      
REMARK 465     GLU A   164                                                      
REMARK 465     ARG A   165                                                      
REMARK 465     LYS A   166                                                      
REMARK 465     GLU A   167                                                      
REMARK 465     LYS A   168                                                      
REMARK 465     ILE A   169                                                      
REMARK 465     GLN A   170                                                      
REMARK 465     HIS A   171                                                      
REMARK 465     GLU A   172                                                      
REMARK 465     LEU A   173                                                      
REMARK 465     THR A   193                                                      
REMARK 465     ASP A   194                                                      
REMARK 465     TYR A   195                                                      
REMARK 465     GLU A   196                                                      
REMARK 465     THR A   197                                                      
REMARK 465     HIS A   198                                                      
REMARK 465     PRO A   199                                                      
REMARK 465     ASP A   200                                                      
REMARK 465     ASN A   201                                                      
REMARK 465     SER A   202                                                      
REMARK 465     ASN A   203                                                      
REMARK 465     LYS A   204                                                      
REMARK 465     GLN A   205                                                      
REMARK 465     ALA A   206                                                      
REMARK 465     VAL A   207                                                      
REMARK 465     ALA A   208                                                      
REMARK 465     ILE A   209                                                      
REMARK 465     LEU A   210                                                      
REMARK 465     ALA A   211                                                      
REMARK 465     ASP A   212                                                      
REMARK 465     ASP A   213                                                      
REMARK 465     GLU A   214                                                      
REMARK 465     LYS A   215                                                      
REMARK 465     SER A   216                                                      
REMARK 465     ASP A   217                                                      
REMARK 465     GLU A   218                                                      
REMARK 465     GLU A   219                                                      
REMARK 465     GLU A   220                                                      
REMARK 465     VAL A   221                                                      
REMARK 465     THR A   222                                                      
REMARK 465     GLU A   223                                                      
REMARK 465     MET A   224                                                      
REMARK 465     SER A   225                                                      
REMARK 465     ASN A   226                                                      
REMARK 465     ASN A   227                                                      
REMARK 465     ALA A   228                                                      
REMARK 465     ASN A   229                                                      
REMARK 465     VAL A   230                                                      
REMARK 465     LEU A   231                                                      
REMARK 465     GLY A   232                                                      
REMARK 465     GLY A   233                                                      
REMARK 465     GLU A   234                                                      
REMARK 465     ILE A   235                                                      
REMARK 465     ASN A   236                                                      
REMARK 465     ASP A   237                                                      
REMARK 465     ASN A   238                                                      
REMARK 465     GLU A   239                                                      
REMARK 465     ASP A   240                                                      
REMARK 465     ASP A   241                                                      
REMARK 465     ASP A   242                                                      
REMARK 465     GLU A   243                                                      
REMARK 465     GLU A   244                                                      
REMARK 465     TYR A   245                                                      
REMARK 465     ASP A   246                                                      
REMARK 465     TYR A   247                                                      
REMARK 465     ASN A   248                                                      
REMARK 465     ASP A   249                                                      
REMARK 465     VAL A   250                                                      
REMARK 465     GLU A   251                                                      
REMARK 465     VAL A   252                                                      
REMARK 465     ASN A   253                                                      
REMARK 465     SER A   254                                                      
REMARK 465     LYS A   255                                                      
REMARK 465     LYS A   256                                                      
REMARK 465     LYS A   257                                                      
REMARK 465     ASN A   258                                                      
REMARK 465     LYS A   276                                                      
REMARK 465     THR A   277                                                      
REMARK 465     SER A   278                                                      
REMARK 465     ASN A   279                                                      
REMARK 465     ILE A   280                                                      
REMARK 465     GLU A   281                                                      
REMARK 465     LYS A   390                                                      
REMARK 465     PHE A   391                                                      
REMARK 465     ARG A   392                                                      
REMARK 465     GLU A   393                                                      
REMARK 465     THR A   394                                                      
REMARK 465     THR A   395                                                      
REMARK 465     HIS A   396                                                      
REMARK 465     SER A   397                                                      
REMARK 465     LYS A   398                                                      
REMARK 465     ARG A   399                                                      
REMARK 465     GLU A   400                                                      
REMARK 465     LEU A   401                                                      
REMARK 465     ASP A   402                                                      
REMARK 465     SER A   403                                                      
REMARK 465     GLY A   404                                                      
REMARK 465     ASP A   405                                                      
REMARK 465     ASP A   406                                                      
REMARK 465     GLN A   407                                                      
REMARK 465     PRO A   408                                                      
REMARK 465     GLN A   409                                                      
REMARK 465     SER A   410                                                      
REMARK 465     SER A   411                                                      
REMARK 465     GLU A   412                                                      
REMARK 465     ALA A   413                                                      
REMARK 465     LYS A   414                                                      
REMARK 465     ARG A   415                                                      
REMARK 465     THR A   416                                                      
REMARK 465     LYS A   417                                                      
REMARK 465     PHE A   418                                                      
REMARK 465     SER A   419                                                      
REMARK 465     GLU A   436                                                      
REMARK 465     SER A   437                                                      
REMARK 465     SER A   438                                                      
REMARK 465     LYS A   439                                                      
REMARK 465     GLU A  1826                                                      
REMARK 465     ALA A  1827                                                      
REMARK 465     GLU A  1828                                                      
REMARK 465     VAL A  1829                                                      
REMARK 465     THR A  1830                                                      
REMARK 465     ALA A  1831                                                      
REMARK 465     GLU A  1832                                                      
REMARK 465     VAL A  1833                                                      
REMARK 465     ASN A  1834                                                      
REMARK 465     GLY A  1835                                                      
REMARK 465     GLY A  1836                                                      
REMARK 465     ASP A  1837                                                      
REMARK 465     ASP A  1838                                                      
REMARK 465     GLU A  1839                                                      
REMARK 465     ALA A  1840                                                      
REMARK 465     GLY C  2144                                                      
REMARK 465     ALA C  2145                                                      
REMARK 465     MET C  2146                                                      
REMARK 465     SER C  2147                                                      
REMARK 465     MET B     1                                                      
REMARK 465     THR B     2                                                      
REMARK 465     GLU B     3                                                      
REMARK 465     HIS B     4                                                      
REMARK 465     GLU B     5                                                      
REMARK 465     THR B     6                                                      
REMARK 465     LYS B     7                                                      
REMARK 465     ASP B     8                                                      
REMARK 465     LYS B     9                                                      
REMARK 465     ALA B    10                                                      
REMARK 465     LYS B    11                                                      
REMARK 465     LYS B    12                                                      
REMARK 465     ILE B    13                                                      
REMARK 465     ARG B    14                                                      
REMARK 465     GLU B    15                                                      
REMARK 465     ILE B    16                                                      
REMARK 465     TYR B    17                                                      
REMARK 465     ARG B    18                                                      
REMARK 465     TYR B    19                                                      
REMARK 465     ASP B    20                                                      
REMARK 465     GLU B    21                                                      
REMARK 465     MET B    22                                                      
REMARK 465     SER B    23                                                      
REMARK 465     ASN B    24                                                      
REMARK 465     LYS B    25                                                      
REMARK 465     VAL B    26                                                      
REMARK 465     LEU B    27                                                      
REMARK 465     LYS B    28                                                      
REMARK 465     VAL B    29                                                      
REMARK 465     ASP B    30                                                      
REMARK 465     LYS B    31                                                      
REMARK 465     ARG B    32                                                      
REMARK 465     PHE B    33                                                      
REMARK 465     MET B    34                                                      
REMARK 465     ASN B    35                                                      
REMARK 465     THR B    36                                                      
REMARK 465     SER B    37                                                      
REMARK 465     GLN B    38                                                      
REMARK 465     ASN B    39                                                      
REMARK 465     PRO B    40                                                      
REMARK 465     GLN B    41                                                      
REMARK 465     ARG B    42                                                      
REMARK 465     ASP B    43                                                      
REMARK 465     ALA B    44                                                      
REMARK 465     GLU B    45                                                      
REMARK 465     ILE B    46                                                      
REMARK 465     SER B    47                                                      
REMARK 465     GLN B    48                                                      
REMARK 465     PRO B    49                                                      
REMARK 465     LYS B    50                                                      
REMARK 465     SER B    51                                                      
REMARK 465     MET B    52                                                      
REMARK 465     SER B    53                                                      
REMARK 465     GLY B    54                                                      
REMARK 465     ARG B    55                                                      
REMARK 465     ILE B    56                                                      
REMARK 465     SER B    57                                                      
REMARK 465     ALA B    58                                                      
REMARK 465     LYS B    59                                                      
REMARK 465     ASP B    60                                                      
REMARK 465     MET B    61                                                      
REMARK 465     GLY B    62                                                      
REMARK 465     GLN B    63                                                      
REMARK 465     GLY B    64                                                      
REMARK 465     LEU B    65                                                      
REMARK 465     CYS B    66                                                      
REMARK 465     ASN B    67                                                      
REMARK 465     ASN B    68                                                      
REMARK 465     ILE B    69                                                      
REMARK 465     ASN B    70                                                      
REMARK 465     LYS B    71                                                      
REMARK 465     GLY B    72                                                      
REMARK 465     LEU B    73                                                      
REMARK 465     LYS B    74                                                      
REMARK 465     GLU B    75                                                      
REMARK 465     ASN B    76                                                      
REMARK 465     ASP B    77                                                      
REMARK 465     VAL B    78                                                      
REMARK 465     ALA B    79                                                      
REMARK 465     VAL B    80                                                      
REMARK 465     GLU B    81                                                      
REMARK 465     LYS B    82                                                      
REMARK 465     THR B    83                                                      
REMARK 465     GLY B    84                                                      
REMARK 465     LYS B    85                                                      
REMARK 465     SER B    86                                                      
REMARK 465     ALA B    87                                                      
REMARK 465     SER B    88                                                      
REMARK 465     LEU B    89                                                      
REMARK 465     LYS B    90                                                      
REMARK 465     LYS B    91                                                      
REMARK 465     ILE B    92                                                      
REMARK 465     GLN B    93                                                      
REMARK 465     GLN B    94                                                      
REMARK 465     HIS B    95                                                      
REMARK 465     ASN B    96                                                      
REMARK 465     THR B    97                                                      
REMARK 465     ILE B    98                                                      
REMARK 465     LEU B    99                                                      
REMARK 465     ASN B   100                                                      
REMARK 465     SER B   101                                                      
REMARK 465     SER B   102                                                      
REMARK 465     SER B   103                                                      
REMARK 465     ASP B   104                                                      
REMARK 465     PHE B   105                                                      
REMARK 465     ARG B   106                                                      
REMARK 465     LEU B   107                                                      
REMARK 465     HIS B   108                                                      
REMARK 465     TYR B   109                                                      
REMARK 465     TYR B   110                                                      
REMARK 465     PRO B   111                                                      
REMARK 465     LYS B   112                                                      
REMARK 465     ASP B   113                                                      
REMARK 465     PRO B   114                                                      
REMARK 465     SER B   115                                                      
REMARK 465     ASN B   116                                                      
REMARK 465     ARG B   149                                                      
REMARK 465     GLN B   150                                                      
REMARK 465     LEU B   151                                                      
REMARK 465     LYS B   152                                                      
REMARK 465     GLU B   153                                                      
REMARK 465     ASN B   154                                                      
REMARK 465     GLU B   155                                                      
REMARK 465     GLU B   156                                                      
REMARK 465     ASN B   157                                                      
REMARK 465     GLU B   158                                                      
REMARK 465     ASP B   159                                                      
REMARK 465     GLY B   160                                                      
REMARK 465     ASN B   161                                                      
REMARK 465     ILE B   162                                                      
REMARK 465     GLU B   163                                                      
REMARK 465     GLU B   164                                                      
REMARK 465     ARG B   165                                                      
REMARK 465     LYS B   166                                                      
REMARK 465     GLU B   167                                                      
REMARK 465     LYS B   168                                                      
REMARK 465     ILE B   169                                                      
REMARK 465     GLN B   170                                                      
REMARK 465     HIS B   171                                                      
REMARK 465     GLU B   172                                                      
REMARK 465     LEU B   173                                                      
REMARK 465     LYS B   187                                                      
REMARK 465     LEU B   188                                                      
REMARK 465     MET B   189                                                      
REMARK 465     LYS B   190                                                      
REMARK 465     ASN B   191                                                      
REMARK 465     ILE B   192                                                      
REMARK 465     THR B   193                                                      
REMARK 465     ASP B   194                                                      
REMARK 465     TYR B   195                                                      
REMARK 465     GLU B   196                                                      
REMARK 465     THR B   197                                                      
REMARK 465     HIS B   198                                                      
REMARK 465     PRO B   199                                                      
REMARK 465     ASP B   200                                                      
REMARK 465     ASN B   201                                                      
REMARK 465     SER B   202                                                      
REMARK 465     ASN B   203                                                      
REMARK 465     LYS B   204                                                      
REMARK 465     GLN B   205                                                      
REMARK 465     ALA B   206                                                      
REMARK 465     VAL B   207                                                      
REMARK 465     ALA B   208                                                      
REMARK 465     ILE B   209                                                      
REMARK 465     LEU B   210                                                      
REMARK 465     ALA B   211                                                      
REMARK 465     ASP B   212                                                      
REMARK 465     ASP B   213                                                      
REMARK 465     GLU B   214                                                      
REMARK 465     LYS B   215                                                      
REMARK 465     SER B   216                                                      
REMARK 465     ASP B   217                                                      
REMARK 465     GLU B   218                                                      
REMARK 465     GLU B   219                                                      
REMARK 465     GLU B   220                                                      
REMARK 465     VAL B   221                                                      
REMARK 465     THR B   222                                                      
REMARK 465     GLU B   223                                                      
REMARK 465     MET B   224                                                      
REMARK 465     SER B   225                                                      
REMARK 465     ASN B   226                                                      
REMARK 465     ASN B   227                                                      
REMARK 465     ALA B   228                                                      
REMARK 465     ASN B   229                                                      
REMARK 465     VAL B   230                                                      
REMARK 465     LEU B   231                                                      
REMARK 465     GLY B   232                                                      
REMARK 465     GLY B   233                                                      
REMARK 465     GLU B   234                                                      
REMARK 465     ILE B   235                                                      
REMARK 465     ASN B   236                                                      
REMARK 465     ASP B   237                                                      
REMARK 465     ASN B   238                                                      
REMARK 465     GLU B   239                                                      
REMARK 465     ASP B   240                                                      
REMARK 465     ASP B   241                                                      
REMARK 465     ASP B   242                                                      
REMARK 465     GLU B   243                                                      
REMARK 465     GLU B   244                                                      
REMARK 465     TYR B   245                                                      
REMARK 465     ASP B   246                                                      
REMARK 465     TYR B   247                                                      
REMARK 465     ASN B   248                                                      
REMARK 465     ASP B   249                                                      
REMARK 465     VAL B   250                                                      
REMARK 465     GLU B   251                                                      
REMARK 465     VAL B   252                                                      
REMARK 465     ASN B   253                                                      
REMARK 465     SER B   254                                                      
REMARK 465     LYS B   255                                                      
REMARK 465     LYS B   256                                                      
REMARK 465     LYS B   257                                                      
REMARK 465     SER B   275                                                      
REMARK 465     LYS B   276                                                      
REMARK 465     THR B   277                                                      
REMARK 465     SER B   278                                                      
REMARK 465     ASN B   279                                                      
REMARK 465     ILE B   280                                                      
REMARK 465     GLU B   281                                                      
REMARK 465     LEU B   345                                                      
REMARK 465     ALA B   346                                                      
REMARK 465     GLU B   347                                                      
REMARK 465     PHE B   348                                                      
REMARK 465     ILE B   349                                                      
REMARK 465     LEU B   350                                                      
REMARK 465     LYS B   351                                                      
REMARK 465     ASN B   352                                                      
REMARK 465     ARG B   353                                                      
REMARK 465     SER B   354                                                      
REMARK 465     THR B   355                                                      
REMARK 465     ILE B   356                                                      
REMARK 465     PHE B   357                                                      
REMARK 465     TRP B   358                                                      
REMARK 465     GLY B   359                                                      
REMARK 465     ILE B   360                                                      
REMARK 465     ARG B   361                                                      
REMARK 465     LEU B   362                                                      
REMARK 465     ALA B   363                                                      
REMARK 465     LYS B   364                                                      
REMARK 465     SER B   365                                                      
REMARK 465     THR B   366                                                      
REMARK 465     LYS B   380                                                      
REMARK 465     GLY B   381                                                      
REMARK 465     LEU B   382                                                      
REMARK 465     ASN B   383                                                      
REMARK 465     ASP B   384                                                      
REMARK 465     LEU B   385                                                      
REMARK 465     VAL B   386                                                      
REMARK 465     GLU B   387                                                      
REMARK 465     GLN B   388                                                      
REMARK 465     TYR B   389                                                      
REMARK 465     LYS B   390                                                      
REMARK 465     PHE B   391                                                      
REMARK 465     ARG B   392                                                      
REMARK 465     GLU B   393                                                      
REMARK 465     THR B   394                                                      
REMARK 465     THR B   395                                                      
REMARK 465     HIS B   396                                                      
REMARK 465     SER B   397                                                      
REMARK 465     LYS B   398                                                      
REMARK 465     ARG B   399                                                      
REMARK 465     GLU B   400                                                      
REMARK 465     LEU B   401                                                      
REMARK 465     ASP B   402                                                      
REMARK 465     SER B   403                                                      
REMARK 465     GLY B   404                                                      
REMARK 465     ASP B   405                                                      
REMARK 465     ASP B   406                                                      
REMARK 465     GLN B   407                                                      
REMARK 465     PRO B   408                                                      
REMARK 465     GLN B   409                                                      
REMARK 465     SER B   410                                                      
REMARK 465     SER B   411                                                      
REMARK 465     GLU B   412                                                      
REMARK 465     ALA B   413                                                      
REMARK 465     LYS B   414                                                      
REMARK 465     ARG B   415                                                      
REMARK 465     THR B   416                                                      
REMARK 465     LYS B   417                                                      
REMARK 465     PHE B   418                                                      
REMARK 465     SER B   419                                                      
REMARK 465     GLU B   436                                                      
REMARK 465     SER B   437                                                      
REMARK 465     SER B   438                                                      
REMARK 465     LYS B   439                                                      
REMARK 465     LEU B   440                                                      
REMARK 465     MET B   441                                                      
REMARK 465     THR B   442                                                      
REMARK 465     VAL B   443                                                      
REMARK 465     VAL B  1829                                                      
REMARK 465     THR B  1830                                                      
REMARK 465     ALA B  1831                                                      
REMARK 465     GLU B  1832                                                      
REMARK 465     VAL B  1833                                                      
REMARK 465     ASN B  1834                                                      
REMARK 465     GLY B  1835                                                      
REMARK 465     GLY B  1836                                                      
REMARK 465     ASP B  1837                                                      
REMARK 465     ASP B  1838                                                      
REMARK 465     GLU B  1839                                                      
REMARK 465     ALA B  1840                                                      
REMARK 465     GLY D  2144                                                      
REMARK 465     ALA D  2145                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     MET D2146    CG   SD   CE                                        
REMARK 470     SER D2147    OG                                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    MET A 189      165.12     68.44                                   
REMARK 500    ASN A 191       88.39   -161.41                                   
REMARK 500    ILE A 265       79.53     61.81                                   
REMARK 500    ASP A 274     -173.53     59.53                                   
REMARK 500    VAL A 283       98.22     66.23                                   
REMARK 500    PHE A 291       47.38   -106.80                                   
REMARK 500    LEU A 323       50.64   -106.25                                   
REMARK 500    LYS A 339       54.30     70.25                                   
REMARK 500    PHE A 340      179.91     66.89                                   
REMARK 500    SER A 344      -99.72     65.61                                   
REMARK 500    LEU A 345       18.07     57.79                                   
REMARK 500    GLU A 367      -62.79     71.73                                   
REMARK 500    ASN A 368       55.90    -93.63                                   
REMARK 500    VAL A 443       51.32     37.56                                   
REMARK 500    LYS A 445      108.74     68.29                                   
REMARK 500    THR A 497      -64.94     71.79                                   
REMARK 500    SER A 525     -147.58     55.11                                   
REMARK 500    LEU A 578       40.99   -104.16                                   
REMARK 500    SER A 595       48.70    -93.27                                   
REMARK 500    GLN A 603      -31.78     91.46                                   
REMARK 500    LEU A 630      110.49   -161.24                                   
REMARK 500    TRP A 656       52.16    -98.79                                   
REMARK 500    ALA A 657       40.86   -160.98                                   
REMARK 500    ILE A 766     -131.82     59.73                                   
REMARK 500    THR A 771       72.73     37.97                                   
REMARK 500    ALA A 775      -70.56     65.57                                   
REMARK 500    ILE A 801      121.48     72.89                                   
REMARK 500    ASN A 839       83.43     63.41                                   
REMARK 500    ASP A 959      113.34   -161.33                                   
REMARK 500    ASP A 994       77.40     66.84                                   
REMARK 500    LEU A1022       94.05    -69.32                                   
REMARK 500    PHE A1041       40.67   -108.15                                   
REMARK 500    LYS A1060       48.84   -103.21                                   
REMARK 500    ARG A1184      -71.48     65.53                                   
REMARK 500    LYS A1190      -55.05     74.68                                   
REMARK 500    SER A1235       26.94   -149.30                                   
REMARK 500    LEU A1236      105.31   -168.69                                   
REMARK 500    ASN A1326       48.08   -102.50                                   
REMARK 500    GLU A1344      -64.89     71.30                                   
REMARK 500    PHE A1416     -155.80    -98.46                                   
REMARK 500    HIS A1418       38.53   -154.08                                   
REMARK 500    ALA A1420       87.88     61.81                                   
REMARK 500    LYS A1423      -48.91     79.66                                   
REMARK 500    ILE A1424       84.50     43.75                                   
REMARK 500    LEU A1428     -175.91     61.08                                   
REMARK 500    ARG A1458       59.08    -92.53                                   
REMARK 500    ASN A1531       52.77    -93.15                                   
REMARK 500    VAL A1554       31.02   -145.76                                   
REMARK 500    PHE A1601      -65.70     64.94                                   
REMARK 500    TRP A1607       73.80   -163.27                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     135 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 PRO B 2133     THR B 2134                  148.70                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  5M52 A    1  2163  UNP    P32639   BRR2_YEAST       1   2163             
DBREF  5M52 C 2147  2413  UNP    P33334   PRP8_YEAST    2147   2413             
DBREF  5M52 B    1  2163  UNP    P32639   BRR2_YEAST       1   2163             
DBREF  5M52 D 2147  2413  UNP    P33334   PRP8_YEAST    2147   2413             
SEQADV 5M52 GLY C 2144  UNP  P33334              EXPRESSION TAG                 
SEQADV 5M52 ALA C 2145  UNP  P33334              EXPRESSION TAG                 
SEQADV 5M52 MET C 2146  UNP  P33334              EXPRESSION TAG                 
SEQADV 5M52 GLY D 2144  UNP  P33334              EXPRESSION TAG                 
SEQADV 5M52 ALA D 2145  UNP  P33334              EXPRESSION TAG                 
SEQADV 5M52 MET D 2146  UNP  P33334              EXPRESSION TAG                 
SEQRES   1 A 2163  MET THR GLU HIS GLU THR LYS ASP LYS ALA LYS LYS ILE          
SEQRES   2 A 2163  ARG GLU ILE TYR ARG TYR ASP GLU MET SER ASN LYS VAL          
SEQRES   3 A 2163  LEU LYS VAL ASP LYS ARG PHE MET ASN THR SER GLN ASN          
SEQRES   4 A 2163  PRO GLN ARG ASP ALA GLU ILE SER GLN PRO LYS SER MET          
SEQRES   5 A 2163  SER GLY ARG ILE SER ALA LYS ASP MET GLY GLN GLY LEU          
SEQRES   6 A 2163  CYS ASN ASN ILE ASN LYS GLY LEU LYS GLU ASN ASP VAL          
SEQRES   7 A 2163  ALA VAL GLU LYS THR GLY LYS SER ALA SER LEU LYS LYS          
SEQRES   8 A 2163  ILE GLN GLN HIS ASN THR ILE LEU ASN SER SER SER ASP          
SEQRES   9 A 2163  PHE ARG LEU HIS TYR TYR PRO LYS ASP PRO SER ASN VAL          
SEQRES  10 A 2163  GLU THR TYR GLU GLN ILE LEU GLN TRP VAL THR GLU VAL          
SEQRES  11 A 2163  LEU GLY ASN ASP ILE PRO HIS ASP LEU ILE ILE GLY THR          
SEQRES  12 A 2163  ALA ASP ILE PHE ILE ARG GLN LEU LYS GLU ASN GLU GLU          
SEQRES  13 A 2163  ASN GLU ASP GLY ASN ILE GLU GLU ARG LYS GLU LYS ILE          
SEQRES  14 A 2163  GLN HIS GLU LEU GLY ILE ASN ILE ASP SER LEU LYS PHE          
SEQRES  15 A 2163  ASN GLU LEU VAL LYS LEU MET LYS ASN ILE THR ASP TYR          
SEQRES  16 A 2163  GLU THR HIS PRO ASP ASN SER ASN LYS GLN ALA VAL ALA          
SEQRES  17 A 2163  ILE LEU ALA ASP ASP GLU LYS SER ASP GLU GLU GLU VAL          
SEQRES  18 A 2163  THR GLU MET SER ASN ASN ALA ASN VAL LEU GLY GLY GLU          
SEQRES  19 A 2163  ILE ASN ASP ASN GLU ASP ASP ASP GLU GLU TYR ASP TYR          
SEQRES  20 A 2163  ASN ASP VAL GLU VAL ASN SER LYS LYS LYS ASN LYS ARG          
SEQRES  21 A 2163  ALA LEU PRO ASN ILE GLU ASN ASP ILE ILE LYS LEU SER          
SEQRES  22 A 2163  ASP SER LYS THR SER ASN ILE GLU SER VAL PRO ILE TYR          
SEQRES  23 A 2163  SER ILE ASP GLU PHE PHE LEU GLN ARG LYS LEU ARG SER          
SEQRES  24 A 2163  GLU LEU GLY TYR LYS ASP THR SER VAL ILE GLN ASP LEU          
SEQRES  25 A 2163  SER GLU LYS ILE LEU ASN ASP ILE GLU THR LEU GLU HIS          
SEQRES  26 A 2163  ASN PRO VAL ALA LEU GLU GLN LYS LEU VAL ASP LEU LEU          
SEQRES  27 A 2163  LYS PHE GLU ASN ILE SER LEU ALA GLU PHE ILE LEU LYS          
SEQRES  28 A 2163  ASN ARG SER THR ILE PHE TRP GLY ILE ARG LEU ALA LYS          
SEQRES  29 A 2163  SER THR GLU ASN GLU ILE PRO ASN LEU ILE GLU LYS MET          
SEQRES  30 A 2163  VAL ALA LYS GLY LEU ASN ASP LEU VAL GLU GLN TYR LYS          
SEQRES  31 A 2163  PHE ARG GLU THR THR HIS SER LYS ARG GLU LEU ASP SER          
SEQRES  32 A 2163  GLY ASP ASP GLN PRO GLN SER SER GLU ALA LYS ARG THR          
SEQRES  33 A 2163  LYS PHE SER ASN PRO ALA ILE PRO PRO VAL ILE ASP LEU          
SEQRES  34 A 2163  GLU LYS ILE LYS PHE ASP GLU SER SER LYS LEU MET THR          
SEQRES  35 A 2163  VAL THR LYS VAL SER LEU PRO GLU GLY SER PHE LYS ARG          
SEQRES  36 A 2163  VAL LYS PRO GLN TYR ASP GLU ILE HIS ILE PRO ALA PRO          
SEQRES  37 A 2163  SER LYS PRO VAL ILE ASP TYR GLU LEU LYS GLU ILE THR          
SEQRES  38 A 2163  SER LEU PRO ASP TRP CYS GLN GLU ALA PHE PRO SER SER          
SEQRES  39 A 2163  GLU THR THR SER LEU ASN PRO ILE GLN SER LYS VAL PHE          
SEQRES  40 A 2163  HIS ALA ALA PHE GLU GLY ASP SER ASN MET LEU ILE CYS          
SEQRES  41 A 2163  ALA PRO THR GLY SER GLY LYS THR ASN ILE ALA LEU LEU          
SEQRES  42 A 2163  THR VAL LEU LYS ALA LEU SER HIS HIS TYR ASN PRO LYS          
SEQRES  43 A 2163  THR LYS LYS LEU ASN LEU SER ALA PHE LYS ILE VAL TYR          
SEQRES  44 A 2163  ILE ALA PRO LEU LYS ALA LEU VAL GLN GLU GLN VAL ARG          
SEQRES  45 A 2163  GLU PHE GLN ARG ARG LEU ALA PHE LEU GLY ILE LYS VAL          
SEQRES  46 A 2163  ALA GLU LEU THR GLY ASP SER ARG LEU SER ARG LYS GLN          
SEQRES  47 A 2163  ILE ASP GLU THR GLN VAL LEU VAL SER THR PRO GLU LYS          
SEQRES  48 A 2163  TRP ASP ILE THR THR ARG ASN SER ASN ASN LEU ALA ILE          
SEQRES  49 A 2163  VAL GLU LEU VAL ARG LEU LEU ILE ILE ASP GLU ILE HIS          
SEQRES  50 A 2163  LEU LEU HIS ASP ASP ARG GLY PRO VAL LEU GLU SER ILE          
SEQRES  51 A 2163  VAL ALA ARG THR PHE TRP ALA SER LYS TYR GLY GLN GLU          
SEQRES  52 A 2163  TYR PRO ARG ILE ILE GLY LEU SER ALA THR LEU PRO ASN          
SEQRES  53 A 2163  TYR GLU ASP VAL GLY ARG PHE LEU ARG VAL PRO LYS GLU          
SEQRES  54 A 2163  GLY LEU PHE TYR PHE ASP SER SER PHE ARG PRO CYS PRO          
SEQRES  55 A 2163  LEU SER GLN GLN PHE CYS GLY ILE LYS GLU ARG ASN SER          
SEQRES  56 A 2163  LEU LYS LYS LEU LYS ALA MET ASN ASP ALA CYS TYR GLU          
SEQRES  57 A 2163  LYS VAL LEU GLU SER ILE ASN GLU GLY ASN GLN ILE ILE          
SEQRES  58 A 2163  VAL PHE VAL HIS SER ARG LYS GLU THR SER ARG THR ALA          
SEQRES  59 A 2163  THR TRP LEU LYS ASN LYS PHE ALA GLU GLU ASN ILE THR          
SEQRES  60 A 2163  HIS LYS LEU THR LYS ASN ASP ALA GLY SER LYS GLN ILE          
SEQRES  61 A 2163  LEU LYS THR GLU ALA ALA ASN VAL LEU ASP PRO SER LEU          
SEQRES  62 A 2163  ARG LYS LEU ILE GLU SER GLY ILE GLY THR HIS HIS ALA          
SEQRES  63 A 2163  GLY LEU THR ARG SER ASP ARG SER LEU SER GLU ASP LEU          
SEQRES  64 A 2163  PHE ALA ASP GLY LEU LEU GLN VAL LEU VAL CYS THR ALA          
SEQRES  65 A 2163  THR LEU ALA TRP GLY VAL ASN LEU PRO ALA HIS THR VAL          
SEQRES  66 A 2163  ILE ILE LYS GLY THR ASP VAL TYR SER PRO GLU LYS GLY          
SEQRES  67 A 2163  SER TRP GLU GLN LEU SER PRO GLN ASP VAL LEU GLN MET          
SEQRES  68 A 2163  LEU GLY ARG ALA GLY ARG PRO ARG TYR ASP THR PHE GLY          
SEQRES  69 A 2163  GLU GLY ILE ILE ILE THR ASP GLN SER ASN VAL GLN TYR          
SEQRES  70 A 2163  TYR LEU SER VAL LEU ASN GLN GLN LEU PRO ILE GLU SER          
SEQRES  71 A 2163  GLN PHE VAL SER LYS LEU VAL ASP ASN LEU ASN ALA GLU          
SEQRES  72 A 2163  VAL VAL ALA GLY ASN ILE LYS CYS ARG ASN ASP ALA VAL          
SEQRES  73 A 2163  ASN TRP LEU ALA TYR THR TYR LEU TYR VAL ARG MET LEU          
SEQRES  74 A 2163  ALA SER PRO MET LEU TYR LYS VAL PRO ASP ILE SER SER          
SEQRES  75 A 2163  ASP GLY GLN LEU LYS LYS PHE ARG GLU SER LEU VAL HIS          
SEQRES  76 A 2163  SER ALA LEU CYS ILE LEU LYS GLU GLN GLU LEU VAL LEU          
SEQRES  77 A 2163  TYR ASP ALA GLU ASN ASP VAL ILE GLU ALA THR ASP LEU          
SEQRES  78 A 2163  GLY ASN ILE ALA SER SER PHE TYR ILE ASN HIS ALA SER          
SEQRES  79 A 2163  MET ASP VAL TYR ASN ARG GLU LEU ASP GLU HIS THR THR          
SEQRES  80 A 2163  GLN ILE ASP LEU PHE ARG ILE PHE SER MET SER GLU GLU          
SEQRES  81 A 2163  PHE LYS TYR VAL SER VAL ARG TYR GLU GLU LYS ARG GLU          
SEQRES  82 A 2163  LEU LYS GLN LEU LEU GLU LYS ALA PRO ILE PRO ILE ARG          
SEQRES  83 A 2163  GLU ASP ILE ASP ASP PRO LEU ALA LYS VAL ASN VAL LEU          
SEQRES  84 A 2163  LEU GLN SER TYR PHE SER GLN LEU LYS PHE GLU GLY PHE          
SEQRES  85 A 2163  ALA LEU ASN SER ASP ILE VAL PHE ILE HIS GLN ASN ALA          
SEQRES  86 A 2163  GLY ARG LEU LEU ARG ALA MET PHE GLU ILE CYS LEU LYS          
SEQRES  87 A 2163  ARG GLY TRP GLY HIS PRO THR ARG MET LEU LEU ASN LEU          
SEQRES  88 A 2163  CYS LYS SER ALA THR THR LYS MET TRP PRO THR ASN CYS          
SEQRES  89 A 2163  PRO LEU ARG GLN PHE LYS THR CYS PRO VAL GLU VAL ILE          
SEQRES  90 A 2163  LYS ARG LEU GLU ALA SER THR VAL PRO TRP GLY ASP TYR          
SEQRES  91 A 2163  LEU GLN LEU GLU THR PRO ALA GLU VAL GLY ARG ALA ILE          
SEQRES  92 A 2163  ARG SER GLU LYS TYR GLY LYS GLN VAL TYR ASP LEU LEU          
SEQRES  93 A 2163  LYS ARG PHE PRO LYS MET SER VAL THR CYS ASN ALA GLN          
SEQRES  94 A 2163  PRO ILE THR ARG SER VAL MET ARG PHE ASN ILE GLU ILE          
SEQRES  95 A 2163  ILE ALA ASP TRP ILE TRP ASP MET ASN VAL HIS GLY SER          
SEQRES  96 A 2163  LEU GLU PRO PHE LEU LEU MET LEU GLU ASP THR ASP GLY          
SEQRES  97 A 2163  ASP SER ILE LEU TYR TYR ASP VAL LEU PHE ILE THR PRO          
SEQRES  98 A 2163  ASP ILE VAL GLY HIS GLU PHE THR LEU SER PHE THR TYR          
SEQRES  99 A 2163  GLU LEU LYS GLN HIS ASN GLN ASN ASN LEU PRO PRO ASN          
SEQRES 100 A 2163  PHE PHE LEU THR LEU ILE SER GLU ASN TRP TRP HIS SER          
SEQRES 101 A 2163  GLU PHE GLU ILE PRO VAL SER PHE ASN GLY PHE LYS LEU          
SEQRES 102 A 2163  PRO LYS LYS PHE PRO PRO PRO THR PRO LEU LEU GLU ASN          
SEQRES 103 A 2163  ILE SER ILE SER THR SER GLU LEU GLY ASN ASP ASP PHE          
SEQRES 104 A 2163  SER GLU VAL PHE GLU PHE LYS THR PHE ASN LYS ILE GLN          
SEQRES 105 A 2163  SER GLN VAL PHE GLU SER LEU TYR ASN SER ASN ASP SER          
SEQRES 106 A 2163  VAL PHE VAL GLY SER GLY LYS GLY THR GLY LYS THR ALA          
SEQRES 107 A 2163  MET ALA GLU LEU ALA LEU LEU ASN HIS TRP ARG GLN ASN          
SEQRES 108 A 2163  LYS GLY ARG ALA VAL TYR ILE ASN PRO SER GLY GLU LYS          
SEQRES 109 A 2163  ILE ASP PHE LEU LEU SER ASP TRP ASN LYS ARG PHE SER          
SEQRES 110 A 2163  HIS LEU ALA GLY GLY LYS ILE ILE ASN LYS LEU GLY ASN          
SEQRES 111 A 2163  ASP PRO SER LEU ASN LEU LYS LEU LEU ALA LYS SER HIS          
SEQRES 112 A 2163  VAL LEU LEU ALA THR PRO VAL GLN PHE GLU LEU LEU SER          
SEQRES 113 A 2163  ARG ARG TRP ARG GLN ARG LYS ASN ILE GLN SER LEU GLU          
SEQRES 114 A 2163  LEU MET ILE TYR ASP ASP ALA HIS GLU ILE SER GLN GLY          
SEQRES 115 A 2163  VAL TYR GLY ALA VAL TYR GLU THR LEU ILE SER ARG MET          
SEQRES 116 A 2163  ILE PHE ILE ALA THR GLN LEU GLU LYS LYS ILE ARG PHE          
SEQRES 117 A 2163  VAL CYS LEU SER ASN CYS LEU ALA ASN ALA ARG ASP PHE          
SEQRES 118 A 2163  GLY GLU TRP ALA GLY MET THR LYS SER ASN ILE TYR ASN          
SEQRES 119 A 2163  PHE SER PRO SER GLU ARG ILE GLU PRO LEU GLU ILE ASN          
SEQRES 120 A 2163  ILE GLN SER PHE LYS ASP VAL GLU HIS ILE SER PHE ASN          
SEQRES 121 A 2163  PHE SER MET LEU GLN MET ALA PHE GLU ALA SER ALA ALA          
SEQRES 122 A 2163  ALA ALA GLY ASN ARG ASN SER SER SER VAL PHE LEU PRO          
SEQRES 123 A 2163  SER ARG LYS ASP CYS MET GLU VAL ALA SER ALA PHE MET          
SEQRES 124 A 2163  LYS PHE SER LYS ALA ILE GLU TRP ASP MET LEU ASN VAL          
SEQRES 125 A 2163  GLU GLU GLU GLN ILE VAL PRO TYR ILE GLU LYS LEU THR          
SEQRES 126 A 2163  ASP GLY HIS LEU ARG ALA PRO LEU LYS HIS GLY VAL GLY          
SEQRES 127 A 2163  ILE LEU TYR LYS GLY MET ALA SER ASN ASP GLU ARG ILE          
SEQRES 128 A 2163  VAL LYS ARG LEU TYR GLU TYR GLY ALA VAL SER VAL LEU          
SEQRES 129 A 2163  LEU ILE SER LYS ASP CYS SER ALA PHE ALA CYS LYS THR          
SEQRES 130 A 2163  ASP GLU VAL ILE ILE LEU GLY THR ASN LEU TYR ASP GLY          
SEQRES 131 A 2163  ALA GLU HIS LYS TYR MET PRO TYR THR ILE ASN GLU LEU          
SEQRES 132 A 2163  LEU GLU MET VAL GLY LEU ALA SER GLY ASN ASP SER MET          
SEQRES 133 A 2163  ALA GLY LYS VAL LEU ILE LEU THR SER HIS ASN MET LYS          
SEQRES 134 A 2163  ALA TYR TYR LYS LYS PHE LEU ILE GLU PRO LEU PRO THR          
SEQRES 135 A 2163  GLU SER TYR LEU GLN TYR ILE ILE HIS ASP THR LEU ASN          
SEQRES 136 A 2163  ASN GLU ILE ALA ASN SER ILE ILE GLN SER LYS GLN ASP          
SEQRES 137 A 2163  CYS VAL ASP TRP PHE THR TYR SER TYR PHE TYR ARG ARG          
SEQRES 138 A 2163  ILE HIS VAL ASN PRO SER TYR TYR GLY VAL ARG ASP THR          
SEQRES 139 A 2163  SER PRO HIS GLY ILE SER VAL PHE LEU SER ASN LEU VAL          
SEQRES 140 A 2163  GLU THR CYS LEU ASN ASP LEU VAL GLU SER SER PHE ILE          
SEQRES 141 A 2163  GLU ILE ASP ASP THR GLU ALA GLU VAL THR ALA GLU VAL          
SEQRES 142 A 2163  ASN GLY GLY ASP ASP GLU ALA THR GLU ILE ILE SER THR          
SEQRES 143 A 2163  LEU SER ASN GLY LEU ILE ALA SER HIS TYR GLY VAL SER          
SEQRES 144 A 2163  PHE PHE THR ILE GLN SER PHE VAL SER SER LEU SER ASN          
SEQRES 145 A 2163  THR SER THR LEU LYS ASN MET LEU TYR VAL LEU SER THR          
SEQRES 146 A 2163  ALA VAL GLU PHE GLU SER VAL PRO LEU ARG LYS GLY ASP          
SEQRES 147 A 2163  ARG ALA LEU LEU VAL LYS LEU SER LYS ARG LEU PRO LEU          
SEQRES 148 A 2163  ARG PHE PRO GLU HIS THR SER SER GLY SER VAL SER PHE          
SEQRES 149 A 2163  LYS VAL PHE LEU LEU LEU GLN ALA TYR PHE SER ARG LEU          
SEQRES 150 A 2163  GLU LEU PRO VAL ASP PHE GLN ASN ASP LEU LYS ASP ILE          
SEQRES 151 A 2163  LEU GLU LYS VAL VAL PRO LEU ILE ASN VAL VAL VAL ASP          
SEQRES 152 A 2163  ILE LEU SER ALA ASN GLY TYR LEU ASN ALA THR THR ALA          
SEQRES 153 A 2163  MET ASP LEU ALA GLN MET LEU ILE GLN GLY VAL TRP ASP          
SEQRES 154 A 2163  VAL ASP ASN PRO LEU ARG GLN ILE PRO HIS PHE ASN ASN          
SEQRES 155 A 2163  LYS ILE LEU GLU LYS CYS LYS GLU ILE ASN VAL GLU THR          
SEQRES 156 A 2163  VAL TYR ASP ILE MET ALA LEU GLU ASP GLU GLU ARG ASP          
SEQRES 157 A 2163  GLU ILE LEU THR LEU THR ASP SER GLN LEU ALA GLN VAL          
SEQRES 158 A 2163  ALA ALA PHE VAL ASN ASN TYR PRO ASN VAL GLU LEU THR          
SEQRES 159 A 2163  TYR SER LEU ASN ASN SER ASP SER LEU ILE SER GLY VAL          
SEQRES 160 A 2163  LYS GLN LYS ILE THR ILE GLN LEU THR ARG ASP VAL GLU          
SEQRES 161 A 2163  PRO GLU ASN LEU GLN VAL THR SER GLU LYS TYR PRO PHE          
SEQRES 162 A 2163  ASP LYS LEU GLU SER TRP TRP LEU VAL LEU GLY GLU VAL          
SEQRES 163 A 2163  SER LYS LYS GLU LEU TYR ALA ILE LYS LYS VAL THR LEU          
SEQRES 164 A 2163  ASN LYS GLU THR GLN GLN TYR GLU LEU GLU PHE ASP THR          
SEQRES 165 A 2163  PRO THR SER GLY LYS HIS ASN LEU THR ILE TRP CYS VAL          
SEQRES 166 A 2163  CYS ASP SER TYR LEU ASP ALA ASP LYS GLU LEU SER PHE          
SEQRES 167 A 2163  GLU ILE ASN VAL LYS                                          
SEQRES   1 C  270  GLY ALA MET SER SER LYS ASN GLU TRP ARG LYS SER ALA          
SEQRES   2 C  270  ILE ALA ASN THR LEU LEU TYR LEU ARG LEU LYS ASN ILE          
SEQRES   3 C  270  TYR VAL SER ALA ASP ASP PHE VAL GLU GLU GLN ASN VAL          
SEQRES   4 C  270  TYR VAL LEU PRO LYS ASN LEU LEU LYS LYS PHE ILE GLU          
SEQRES   5 C  270  ILE SER ASP VAL LYS ILE GLN VAL ALA ALA PHE ILE TYR          
SEQRES   6 C  270  GLY MET SER ALA LYS ASP HIS PRO LYS VAL LYS GLU ILE          
SEQRES   7 C  270  LYS THR VAL VAL LEU VAL PRO GLN LEU GLY HIS VAL GLY          
SEQRES   8 C  270  SER VAL GLN ILE SER ASN ILE PRO ASP ILE GLY ASP LEU          
SEQRES   9 C  270  PRO ASP THR GLU GLY LEU GLU LEU LEU GLY TRP ILE HIS          
SEQRES  10 C  270  THR GLN THR GLU GLU LEU LYS PHE MET ALA ALA SER GLU          
SEQRES  11 C  270  VAL ALA THR HIS SER LYS LEU PHE ALA ASP LYS LYS ARG          
SEQRES  12 C  270  ASP CYS ILE ASP ILE SER ILE PHE SER THR PRO GLY SER          
SEQRES  13 C  270  VAL SER LEU SER ALA TYR ASN LEU THR ASP GLU GLY TYR          
SEQRES  14 C  270  GLN TRP GLY GLU GLU ASN LYS ASP ILE MET ASN VAL LEU          
SEQRES  15 C  270  SER GLU GLY PHE GLU PRO THR PHE SER THR HIS ALA GLN          
SEQRES  16 C  270  LEU LEU LEU SER ASP ARG ILE THR GLY ASN PHE ILE ILE          
SEQRES  17 C  270  PRO SER GLY ASN VAL TRP ASN TYR THR PHE MET GLY THR          
SEQRES  18 C  270  ALA PHE ASN GLN GLU GLY ASP TYR ASN PHE LYS TYR GLY          
SEQRES  19 C  270  ILE PRO LEU GLU PHE TYR ASN GLU MET HIS ARG PRO VAL          
SEQRES  20 C  270  HIS PHE LEU GLN PHE SER GLU LEU ALA GLY ASP GLU GLU          
SEQRES  21 C  270  LEU GLU ALA GLU GLN ILE ASP VAL PHE SER                      
SEQRES   1 B 2163  MET THR GLU HIS GLU THR LYS ASP LYS ALA LYS LYS ILE          
SEQRES   2 B 2163  ARG GLU ILE TYR ARG TYR ASP GLU MET SER ASN LYS VAL          
SEQRES   3 B 2163  LEU LYS VAL ASP LYS ARG PHE MET ASN THR SER GLN ASN          
SEQRES   4 B 2163  PRO GLN ARG ASP ALA GLU ILE SER GLN PRO LYS SER MET          
SEQRES   5 B 2163  SER GLY ARG ILE SER ALA LYS ASP MET GLY GLN GLY LEU          
SEQRES   6 B 2163  CYS ASN ASN ILE ASN LYS GLY LEU LYS GLU ASN ASP VAL          
SEQRES   7 B 2163  ALA VAL GLU LYS THR GLY LYS SER ALA SER LEU LYS LYS          
SEQRES   8 B 2163  ILE GLN GLN HIS ASN THR ILE LEU ASN SER SER SER ASP          
SEQRES   9 B 2163  PHE ARG LEU HIS TYR TYR PRO LYS ASP PRO SER ASN VAL          
SEQRES  10 B 2163  GLU THR TYR GLU GLN ILE LEU GLN TRP VAL THR GLU VAL          
SEQRES  11 B 2163  LEU GLY ASN ASP ILE PRO HIS ASP LEU ILE ILE GLY THR          
SEQRES  12 B 2163  ALA ASP ILE PHE ILE ARG GLN LEU LYS GLU ASN GLU GLU          
SEQRES  13 B 2163  ASN GLU ASP GLY ASN ILE GLU GLU ARG LYS GLU LYS ILE          
SEQRES  14 B 2163  GLN HIS GLU LEU GLY ILE ASN ILE ASP SER LEU LYS PHE          
SEQRES  15 B 2163  ASN GLU LEU VAL LYS LEU MET LYS ASN ILE THR ASP TYR          
SEQRES  16 B 2163  GLU THR HIS PRO ASP ASN SER ASN LYS GLN ALA VAL ALA          
SEQRES  17 B 2163  ILE LEU ALA ASP ASP GLU LYS SER ASP GLU GLU GLU VAL          
SEQRES  18 B 2163  THR GLU MET SER ASN ASN ALA ASN VAL LEU GLY GLY GLU          
SEQRES  19 B 2163  ILE ASN ASP ASN GLU ASP ASP ASP GLU GLU TYR ASP TYR          
SEQRES  20 B 2163  ASN ASP VAL GLU VAL ASN SER LYS LYS LYS ASN LYS ARG          
SEQRES  21 B 2163  ALA LEU PRO ASN ILE GLU ASN ASP ILE ILE LYS LEU SER          
SEQRES  22 B 2163  ASP SER LYS THR SER ASN ILE GLU SER VAL PRO ILE TYR          
SEQRES  23 B 2163  SER ILE ASP GLU PHE PHE LEU GLN ARG LYS LEU ARG SER          
SEQRES  24 B 2163  GLU LEU GLY TYR LYS ASP THR SER VAL ILE GLN ASP LEU          
SEQRES  25 B 2163  SER GLU LYS ILE LEU ASN ASP ILE GLU THR LEU GLU HIS          
SEQRES  26 B 2163  ASN PRO VAL ALA LEU GLU GLN LYS LEU VAL ASP LEU LEU          
SEQRES  27 B 2163  LYS PHE GLU ASN ILE SER LEU ALA GLU PHE ILE LEU LYS          
SEQRES  28 B 2163  ASN ARG SER THR ILE PHE TRP GLY ILE ARG LEU ALA LYS          
SEQRES  29 B 2163  SER THR GLU ASN GLU ILE PRO ASN LEU ILE GLU LYS MET          
SEQRES  30 B 2163  VAL ALA LYS GLY LEU ASN ASP LEU VAL GLU GLN TYR LYS          
SEQRES  31 B 2163  PHE ARG GLU THR THR HIS SER LYS ARG GLU LEU ASP SER          
SEQRES  32 B 2163  GLY ASP ASP GLN PRO GLN SER SER GLU ALA LYS ARG THR          
SEQRES  33 B 2163  LYS PHE SER ASN PRO ALA ILE PRO PRO VAL ILE ASP LEU          
SEQRES  34 B 2163  GLU LYS ILE LYS PHE ASP GLU SER SER LYS LEU MET THR          
SEQRES  35 B 2163  VAL THR LYS VAL SER LEU PRO GLU GLY SER PHE LYS ARG          
SEQRES  36 B 2163  VAL LYS PRO GLN TYR ASP GLU ILE HIS ILE PRO ALA PRO          
SEQRES  37 B 2163  SER LYS PRO VAL ILE ASP TYR GLU LEU LYS GLU ILE THR          
SEQRES  38 B 2163  SER LEU PRO ASP TRP CYS GLN GLU ALA PHE PRO SER SER          
SEQRES  39 B 2163  GLU THR THR SER LEU ASN PRO ILE GLN SER LYS VAL PHE          
SEQRES  40 B 2163  HIS ALA ALA PHE GLU GLY ASP SER ASN MET LEU ILE CYS          
SEQRES  41 B 2163  ALA PRO THR GLY SER GLY LYS THR ASN ILE ALA LEU LEU          
SEQRES  42 B 2163  THR VAL LEU LYS ALA LEU SER HIS HIS TYR ASN PRO LYS          
SEQRES  43 B 2163  THR LYS LYS LEU ASN LEU SER ALA PHE LYS ILE VAL TYR          
SEQRES  44 B 2163  ILE ALA PRO LEU LYS ALA LEU VAL GLN GLU GLN VAL ARG          
SEQRES  45 B 2163  GLU PHE GLN ARG ARG LEU ALA PHE LEU GLY ILE LYS VAL          
SEQRES  46 B 2163  ALA GLU LEU THR GLY ASP SER ARG LEU SER ARG LYS GLN          
SEQRES  47 B 2163  ILE ASP GLU THR GLN VAL LEU VAL SER THR PRO GLU LYS          
SEQRES  48 B 2163  TRP ASP ILE THR THR ARG ASN SER ASN ASN LEU ALA ILE          
SEQRES  49 B 2163  VAL GLU LEU VAL ARG LEU LEU ILE ILE ASP GLU ILE HIS          
SEQRES  50 B 2163  LEU LEU HIS ASP ASP ARG GLY PRO VAL LEU GLU SER ILE          
SEQRES  51 B 2163  VAL ALA ARG THR PHE TRP ALA SER LYS TYR GLY GLN GLU          
SEQRES  52 B 2163  TYR PRO ARG ILE ILE GLY LEU SER ALA THR LEU PRO ASN          
SEQRES  53 B 2163  TYR GLU ASP VAL GLY ARG PHE LEU ARG VAL PRO LYS GLU          
SEQRES  54 B 2163  GLY LEU PHE TYR PHE ASP SER SER PHE ARG PRO CYS PRO          
SEQRES  55 B 2163  LEU SER GLN GLN PHE CYS GLY ILE LYS GLU ARG ASN SER          
SEQRES  56 B 2163  LEU LYS LYS LEU LYS ALA MET ASN ASP ALA CYS TYR GLU          
SEQRES  57 B 2163  LYS VAL LEU GLU SER ILE ASN GLU GLY ASN GLN ILE ILE          
SEQRES  58 B 2163  VAL PHE VAL HIS SER ARG LYS GLU THR SER ARG THR ALA          
SEQRES  59 B 2163  THR TRP LEU LYS ASN LYS PHE ALA GLU GLU ASN ILE THR          
SEQRES  60 B 2163  HIS LYS LEU THR LYS ASN ASP ALA GLY SER LYS GLN ILE          
SEQRES  61 B 2163  LEU LYS THR GLU ALA ALA ASN VAL LEU ASP PRO SER LEU          
SEQRES  62 B 2163  ARG LYS LEU ILE GLU SER GLY ILE GLY THR HIS HIS ALA          
SEQRES  63 B 2163  GLY LEU THR ARG SER ASP ARG SER LEU SER GLU ASP LEU          
SEQRES  64 B 2163  PHE ALA ASP GLY LEU LEU GLN VAL LEU VAL CYS THR ALA          
SEQRES  65 B 2163  THR LEU ALA TRP GLY VAL ASN LEU PRO ALA HIS THR VAL          
SEQRES  66 B 2163  ILE ILE LYS GLY THR ASP VAL TYR SER PRO GLU LYS GLY          
SEQRES  67 B 2163  SER TRP GLU GLN LEU SER PRO GLN ASP VAL LEU GLN MET          
SEQRES  68 B 2163  LEU GLY ARG ALA GLY ARG PRO ARG TYR ASP THR PHE GLY          
SEQRES  69 B 2163  GLU GLY ILE ILE ILE THR ASP GLN SER ASN VAL GLN TYR          
SEQRES  70 B 2163  TYR LEU SER VAL LEU ASN GLN GLN LEU PRO ILE GLU SER          
SEQRES  71 B 2163  GLN PHE VAL SER LYS LEU VAL ASP ASN LEU ASN ALA GLU          
SEQRES  72 B 2163  VAL VAL ALA GLY ASN ILE LYS CYS ARG ASN ASP ALA VAL          
SEQRES  73 B 2163  ASN TRP LEU ALA TYR THR TYR LEU TYR VAL ARG MET LEU          
SEQRES  74 B 2163  ALA SER PRO MET LEU TYR LYS VAL PRO ASP ILE SER SER          
SEQRES  75 B 2163  ASP GLY GLN LEU LYS LYS PHE ARG GLU SER LEU VAL HIS          
SEQRES  76 B 2163  SER ALA LEU CYS ILE LEU LYS GLU GLN GLU LEU VAL LEU          
SEQRES  77 B 2163  TYR ASP ALA GLU ASN ASP VAL ILE GLU ALA THR ASP LEU          
SEQRES  78 B 2163  GLY ASN ILE ALA SER SER PHE TYR ILE ASN HIS ALA SER          
SEQRES  79 B 2163  MET ASP VAL TYR ASN ARG GLU LEU ASP GLU HIS THR THR          
SEQRES  80 B 2163  GLN ILE ASP LEU PHE ARG ILE PHE SER MET SER GLU GLU          
SEQRES  81 B 2163  PHE LYS TYR VAL SER VAL ARG TYR GLU GLU LYS ARG GLU          
SEQRES  82 B 2163  LEU LYS GLN LEU LEU GLU LYS ALA PRO ILE PRO ILE ARG          
SEQRES  83 B 2163  GLU ASP ILE ASP ASP PRO LEU ALA LYS VAL ASN VAL LEU          
SEQRES  84 B 2163  LEU GLN SER TYR PHE SER GLN LEU LYS PHE GLU GLY PHE          
SEQRES  85 B 2163  ALA LEU ASN SER ASP ILE VAL PHE ILE HIS GLN ASN ALA          
SEQRES  86 B 2163  GLY ARG LEU LEU ARG ALA MET PHE GLU ILE CYS LEU LYS          
SEQRES  87 B 2163  ARG GLY TRP GLY HIS PRO THR ARG MET LEU LEU ASN LEU          
SEQRES  88 B 2163  CYS LYS SER ALA THR THR LYS MET TRP PRO THR ASN CYS          
SEQRES  89 B 2163  PRO LEU ARG GLN PHE LYS THR CYS PRO VAL GLU VAL ILE          
SEQRES  90 B 2163  LYS ARG LEU GLU ALA SER THR VAL PRO TRP GLY ASP TYR          
SEQRES  91 B 2163  LEU GLN LEU GLU THR PRO ALA GLU VAL GLY ARG ALA ILE          
SEQRES  92 B 2163  ARG SER GLU LYS TYR GLY LYS GLN VAL TYR ASP LEU LEU          
SEQRES  93 B 2163  LYS ARG PHE PRO LYS MET SER VAL THR CYS ASN ALA GLN          
SEQRES  94 B 2163  PRO ILE THR ARG SER VAL MET ARG PHE ASN ILE GLU ILE          
SEQRES  95 B 2163  ILE ALA ASP TRP ILE TRP ASP MET ASN VAL HIS GLY SER          
SEQRES  96 B 2163  LEU GLU PRO PHE LEU LEU MET LEU GLU ASP THR ASP GLY          
SEQRES  97 B 2163  ASP SER ILE LEU TYR TYR ASP VAL LEU PHE ILE THR PRO          
SEQRES  98 B 2163  ASP ILE VAL GLY HIS GLU PHE THR LEU SER PHE THR TYR          
SEQRES  99 B 2163  GLU LEU LYS GLN HIS ASN GLN ASN ASN LEU PRO PRO ASN          
SEQRES 100 B 2163  PHE PHE LEU THR LEU ILE SER GLU ASN TRP TRP HIS SER          
SEQRES 101 B 2163  GLU PHE GLU ILE PRO VAL SER PHE ASN GLY PHE LYS LEU          
SEQRES 102 B 2163  PRO LYS LYS PHE PRO PRO PRO THR PRO LEU LEU GLU ASN          
SEQRES 103 B 2163  ILE SER ILE SER THR SER GLU LEU GLY ASN ASP ASP PHE          
SEQRES 104 B 2163  SER GLU VAL PHE GLU PHE LYS THR PHE ASN LYS ILE GLN          
SEQRES 105 B 2163  SER GLN VAL PHE GLU SER LEU TYR ASN SER ASN ASP SER          
SEQRES 106 B 2163  VAL PHE VAL GLY SER GLY LYS GLY THR GLY LYS THR ALA          
SEQRES 107 B 2163  MET ALA GLU LEU ALA LEU LEU ASN HIS TRP ARG GLN ASN          
SEQRES 108 B 2163  LYS GLY ARG ALA VAL TYR ILE ASN PRO SER GLY GLU LYS          
SEQRES 109 B 2163  ILE ASP PHE LEU LEU SER ASP TRP ASN LYS ARG PHE SER          
SEQRES 110 B 2163  HIS LEU ALA GLY GLY LYS ILE ILE ASN LYS LEU GLY ASN          
SEQRES 111 B 2163  ASP PRO SER LEU ASN LEU LYS LEU LEU ALA LYS SER HIS          
SEQRES 112 B 2163  VAL LEU LEU ALA THR PRO VAL GLN PHE GLU LEU LEU SER          
SEQRES 113 B 2163  ARG ARG TRP ARG GLN ARG LYS ASN ILE GLN SER LEU GLU          
SEQRES 114 B 2163  LEU MET ILE TYR ASP ASP ALA HIS GLU ILE SER GLN GLY          
SEQRES 115 B 2163  VAL TYR GLY ALA VAL TYR GLU THR LEU ILE SER ARG MET          
SEQRES 116 B 2163  ILE PHE ILE ALA THR GLN LEU GLU LYS LYS ILE ARG PHE          
SEQRES 117 B 2163  VAL CYS LEU SER ASN CYS LEU ALA ASN ALA ARG ASP PHE          
SEQRES 118 B 2163  GLY GLU TRP ALA GLY MET THR LYS SER ASN ILE TYR ASN          
SEQRES 119 B 2163  PHE SER PRO SER GLU ARG ILE GLU PRO LEU GLU ILE ASN          
SEQRES 120 B 2163  ILE GLN SER PHE LYS ASP VAL GLU HIS ILE SER PHE ASN          
SEQRES 121 B 2163  PHE SER MET LEU GLN MET ALA PHE GLU ALA SER ALA ALA          
SEQRES 122 B 2163  ALA ALA GLY ASN ARG ASN SER SER SER VAL PHE LEU PRO          
SEQRES 123 B 2163  SER ARG LYS ASP CYS MET GLU VAL ALA SER ALA PHE MET          
SEQRES 124 B 2163  LYS PHE SER LYS ALA ILE GLU TRP ASP MET LEU ASN VAL          
SEQRES 125 B 2163  GLU GLU GLU GLN ILE VAL PRO TYR ILE GLU LYS LEU THR          
SEQRES 126 B 2163  ASP GLY HIS LEU ARG ALA PRO LEU LYS HIS GLY VAL GLY          
SEQRES 127 B 2163  ILE LEU TYR LYS GLY MET ALA SER ASN ASP GLU ARG ILE          
SEQRES 128 B 2163  VAL LYS ARG LEU TYR GLU TYR GLY ALA VAL SER VAL LEU          
SEQRES 129 B 2163  LEU ILE SER LYS ASP CYS SER ALA PHE ALA CYS LYS THR          
SEQRES 130 B 2163  ASP GLU VAL ILE ILE LEU GLY THR ASN LEU TYR ASP GLY          
SEQRES 131 B 2163  ALA GLU HIS LYS TYR MET PRO TYR THR ILE ASN GLU LEU          
SEQRES 132 B 2163  LEU GLU MET VAL GLY LEU ALA SER GLY ASN ASP SER MET          
SEQRES 133 B 2163  ALA GLY LYS VAL LEU ILE LEU THR SER HIS ASN MET LYS          
SEQRES 134 B 2163  ALA TYR TYR LYS LYS PHE LEU ILE GLU PRO LEU PRO THR          
SEQRES 135 B 2163  GLU SER TYR LEU GLN TYR ILE ILE HIS ASP THR LEU ASN          
SEQRES 136 B 2163  ASN GLU ILE ALA ASN SER ILE ILE GLN SER LYS GLN ASP          
SEQRES 137 B 2163  CYS VAL ASP TRP PHE THR TYR SER TYR PHE TYR ARG ARG          
SEQRES 138 B 2163  ILE HIS VAL ASN PRO SER TYR TYR GLY VAL ARG ASP THR          
SEQRES 139 B 2163  SER PRO HIS GLY ILE SER VAL PHE LEU SER ASN LEU VAL          
SEQRES 140 B 2163  GLU THR CYS LEU ASN ASP LEU VAL GLU SER SER PHE ILE          
SEQRES 141 B 2163  GLU ILE ASP ASP THR GLU ALA GLU VAL THR ALA GLU VAL          
SEQRES 142 B 2163  ASN GLY GLY ASP ASP GLU ALA THR GLU ILE ILE SER THR          
SEQRES 143 B 2163  LEU SER ASN GLY LEU ILE ALA SER HIS TYR GLY VAL SER          
SEQRES 144 B 2163  PHE PHE THR ILE GLN SER PHE VAL SER SER LEU SER ASN          
SEQRES 145 B 2163  THR SER THR LEU LYS ASN MET LEU TYR VAL LEU SER THR          
SEQRES 146 B 2163  ALA VAL GLU PHE GLU SER VAL PRO LEU ARG LYS GLY ASP          
SEQRES 147 B 2163  ARG ALA LEU LEU VAL LYS LEU SER LYS ARG LEU PRO LEU          
SEQRES 148 B 2163  ARG PHE PRO GLU HIS THR SER SER GLY SER VAL SER PHE          
SEQRES 149 B 2163  LYS VAL PHE LEU LEU LEU GLN ALA TYR PHE SER ARG LEU          
SEQRES 150 B 2163  GLU LEU PRO VAL ASP PHE GLN ASN ASP LEU LYS ASP ILE          
SEQRES 151 B 2163  LEU GLU LYS VAL VAL PRO LEU ILE ASN VAL VAL VAL ASP          
SEQRES 152 B 2163  ILE LEU SER ALA ASN GLY TYR LEU ASN ALA THR THR ALA          
SEQRES 153 B 2163  MET ASP LEU ALA GLN MET LEU ILE GLN GLY VAL TRP ASP          
SEQRES 154 B 2163  VAL ASP ASN PRO LEU ARG GLN ILE PRO HIS PHE ASN ASN          
SEQRES 155 B 2163  LYS ILE LEU GLU LYS CYS LYS GLU ILE ASN VAL GLU THR          
SEQRES 156 B 2163  VAL TYR ASP ILE MET ALA LEU GLU ASP GLU GLU ARG ASP          
SEQRES 157 B 2163  GLU ILE LEU THR LEU THR ASP SER GLN LEU ALA GLN VAL          
SEQRES 158 B 2163  ALA ALA PHE VAL ASN ASN TYR PRO ASN VAL GLU LEU THR          
SEQRES 159 B 2163  TYR SER LEU ASN ASN SER ASP SER LEU ILE SER GLY VAL          
SEQRES 160 B 2163  LYS GLN LYS ILE THR ILE GLN LEU THR ARG ASP VAL GLU          
SEQRES 161 B 2163  PRO GLU ASN LEU GLN VAL THR SER GLU LYS TYR PRO PHE          
SEQRES 162 B 2163  ASP LYS LEU GLU SER TRP TRP LEU VAL LEU GLY GLU VAL          
SEQRES 163 B 2163  SER LYS LYS GLU LEU TYR ALA ILE LYS LYS VAL THR LEU          
SEQRES 164 B 2163  ASN LYS GLU THR GLN GLN TYR GLU LEU GLU PHE ASP THR          
SEQRES 165 B 2163  PRO THR SER GLY LYS HIS ASN LEU THR ILE TRP CYS VAL          
SEQRES 166 B 2163  CYS ASP SER TYR LEU ASP ALA ASP LYS GLU LEU SER PHE          
SEQRES 167 B 2163  GLU ILE ASN VAL LYS                                          
SEQRES   1 D  270  GLY ALA MET SER SER LYS ASN GLU TRP ARG LYS SER ALA          
SEQRES   2 D  270  ILE ALA ASN THR LEU LEU TYR LEU ARG LEU LYS ASN ILE          
SEQRES   3 D  270  TYR VAL SER ALA ASP ASP PHE VAL GLU GLU GLN ASN VAL          
SEQRES   4 D  270  TYR VAL LEU PRO LYS ASN LEU LEU LYS LYS PHE ILE GLU          
SEQRES   5 D  270  ILE SER ASP VAL LYS ILE GLN VAL ALA ALA PHE ILE TYR          
SEQRES   6 D  270  GLY MET SER ALA LYS ASP HIS PRO LYS VAL LYS GLU ILE          
SEQRES   7 D  270  LYS THR VAL VAL LEU VAL PRO GLN LEU GLY HIS VAL GLY          
SEQRES   8 D  270  SER VAL GLN ILE SER ASN ILE PRO ASP ILE GLY ASP LEU          
SEQRES   9 D  270  PRO ASP THR GLU GLY LEU GLU LEU LEU GLY TRP ILE HIS          
SEQRES  10 D  270  THR GLN THR GLU GLU LEU LYS PHE MET ALA ALA SER GLU          
SEQRES  11 D  270  VAL ALA THR HIS SER LYS LEU PHE ALA ASP LYS LYS ARG          
SEQRES  12 D  270  ASP CYS ILE ASP ILE SER ILE PHE SER THR PRO GLY SER          
SEQRES  13 D  270  VAL SER LEU SER ALA TYR ASN LEU THR ASP GLU GLY TYR          
SEQRES  14 D  270  GLN TRP GLY GLU GLU ASN LYS ASP ILE MET ASN VAL LEU          
SEQRES  15 D  270  SER GLU GLY PHE GLU PRO THR PHE SER THR HIS ALA GLN          
SEQRES  16 D  270  LEU LEU LEU SER ASP ARG ILE THR GLY ASN PHE ILE ILE          
SEQRES  17 D  270  PRO SER GLY ASN VAL TRP ASN TYR THR PHE MET GLY THR          
SEQRES  18 D  270  ALA PHE ASN GLN GLU GLY ASP TYR ASN PHE LYS TYR GLY          
SEQRES  19 D  270  ILE PRO LEU GLU PHE TYR ASN GLU MET HIS ARG PRO VAL          
SEQRES  20 D  270  HIS PHE LEU GLN PHE SER GLU LEU ALA GLY ASP GLU GLU          
SEQRES  21 D  270  LEU GLU ALA GLU GLN ILE ASP VAL PHE SER                      
FORMUL   5  HOH   *10(H2 O)                                                     
HELIX    1 AA1 PRO A  114  GLU A  121  1                                   8    
HELIX    2 AA2 GLN A  122  LEU A  131  1                                  10    
HELIX    3 AA3 PRO A  136  ASN A  154  1                                  19    
HELIX    4 AA4 ILE A  175  LEU A  188  1                                  14    
HELIX    5 AA5 PHE A  291  LEU A  301  1                                  11    
HELIX    6 AA6 ASP A  305  LEU A  323  1                                  19    
HELIX    7 AA7 ASN A  326  LEU A  338  1                                  13    
HELIX    8 AA8 LYS A  339  SER A  344  1                                   6    
HELIX    9 AA9 LEU A  345  ASN A  352  1                                   8    
HELIX   10 AB1 ASN A  352  SER A  365  1                                  14    
HELIX   11 AB2 PRO A  371  ALA A  379  1                                   9    
HELIX   12 AB3 ASP A  428  LYS A  433  1                                   6    
HELIX   13 AB4 PRO A  484  GLN A  488  5                                   5    
HELIX   14 AB5 ASN A  500  PHE A  511  1                                  12    
HELIX   15 AB6 GLY A  526  TYR A  543  1                                  18    
HELIX   16 AB7 LEU A  563  LEU A  578  1                                  16    
HELIX   17 AB8 LYS A  597  THR A  602  1                                   6    
HELIX   18 AB9 THR A  608  ASN A  618  1                                  11    
HELIX   19 AC1 ASN A  621  GLU A  626  1                                   6    
HELIX   20 AC2 GLU A  635  ASP A  641  5                                   7    
HELIX   21 AC3 ARG A  643  TRP A  656  1                                  14    
HELIX   22 AC4 ASN A  676  LEU A  684  1                                   9    
HELIX   23 AC5 ASP A  695  ARG A  699  5                                   5    
HELIX   24 AC6 ASN A  714  GLY A  737  1                                  24    
HELIX   25 AC7 SER A  746  ALA A  762  1                                  17    
HELIX   26 AC8 SER A  777  ALA A  786  1                                  10    
HELIX   27 AC9 ASP A  790  GLY A  800  1                                  11    
HELIX   28 AD1 THR A  809  GLY A  823  1                                  15    
HELIX   29 AD2 ALA A  832  ALA A  835  5                                   4    
HELIX   30 AD3 SER A  864  GLY A  873  1                                  10    
HELIX   31 AD4 ASN A  894  ASN A  903  1                                  10    
HELIX   32 AD5 LYS A  915  ALA A  926  1                                  12    
HELIX   33 AD6 CYS A  931  ALA A  940  1                                  10    
HELIX   34 AD7 THR A  942  SER A  951  1                                  10    
HELIX   35 AD8 ASP A  959  GLY A  964  1                                   6    
HELIX   36 AD9 LEU A  966  GLN A  984  1                                  19    
HELIX   37 AE1 THR A  999  PHE A 1008  1                                  10    
HELIX   38 AE2 ASN A 1011  LEU A 1022  1                                  12    
HELIX   39 AE3 THR A 1027  MET A 1037  1                                  11    
HELIX   40 AE4 SER A 1038  LYS A 1042  5                                   5    
HELIX   41 AE5 ARG A 1047  LYS A 1060  1                                  14    
HELIX   42 AE6 ASP A 1071  GLN A 1086  1                                  16    
HELIX   43 AE7 GLY A 1091  GLY A 1120  1                                  30    
HELIX   44 AE8 TRP A 1121  LYS A 1138  1                                  18    
HELIX   45 AE9 CYS A 1144  GLN A 1148  5                                   5    
HELIX   46 AF1 PRO A 1153  SER A 1163  1                                  11    
HELIX   47 AF2 PRO A 1166  LEU A 1171  5                                   6    
HELIX   48 AF3 THR A 1175  ILE A 1183  1                                   9    
HELIX   49 AF4 LYS A 1190  PHE A 1199  1                                  10    
HELIX   50 AF5 LYS A 1277  ASN A 1283  1                                   7    
HELIX   51 AF6 SER A 1330  LEU A 1334  5                                   5    
HELIX   52 AF7 ASN A 1336  PHE A 1343  1                                   8    
HELIX   53 AF8 ASN A 1349  ASN A 1361  1                                  13    
HELIX   54 AF9 GLY A 1375  ASN A 1391  1                                  17    
HELIX   55 AG1 SER A 1401  PHE A 1416  1                                  16    
HELIX   56 AG2 ASP A 1431  SER A 1442  1                                  12    
HELIX   57 AG3 THR A 1448  SER A 1456  1                                   9    
HELIX   58 AG4 ARG A 1462  SER A 1467  1                                   6    
HELIX   59 AG5 ALA A 1476  SER A 1480  5                                   5    
HELIX   60 AG6 GLN A 1481  LEU A 1502  1                                  22    
HELIX   61 AG7 ALA A 1518  GLY A 1526  1                                   9    
HELIX   62 AG8 ASN A 1560  ASN A 1577  1                                  18    
HELIX   63 AG9 SER A 1587  LYS A 1600  1                                  14    
HELIX   64 AH1 GLU A 1613  LYS A 1623  1                                  11    
HELIX   65 AH2 LEU A 1629  GLY A 1636  1                                   8    
HELIX   66 AH3 ALA A 1645  TYR A 1658  1                                  14    
HELIX   67 AH4 ASP A 1669  SER A 1671  5                                   3    
HELIX   68 AH5 THR A 1699  GLY A 1708  1                                  10    
HELIX   69 AH6 SER A 1725  GLU A 1738  1                                  14    
HELIX   70 AH7 TYR A 1745  TYR A 1748  5                                   4    
HELIX   71 AH8 ILE A 1749  ASN A 1760  1                                  12    
HELIX   72 AH9 SER A 1765  THR A 1774  1                                  10    
HELIX   73 AI1 TYR A 1777  ASN A 1785  1                                   9    
HELIX   74 AI2 PRO A 1786  GLY A 1790  5                                   5    
HELIX   75 AI3 SER A 1795  SER A 1817  1                                  23    
HELIX   76 AI4 LEU A 1847  GLY A 1857  1                                  11    
HELIX   77 AI5 SER A 1859  LEU A 1870  1                                  12    
HELIX   78 AI6 THR A 1875  THR A 1885  1                                  11    
HELIX   79 AI7 ALA A 1886  VAL A 1892  5                                   7    
HELIX   80 AI8 GLY A 1897  LYS A 1907  1                                  11    
HELIX   81 AI9 SER A 1921  ARG A 1936  1                                  16    
HELIX   82 AJ1 PRO A 1940  GLY A 1969  1                                  30    
HELIX   83 AJ2 ASN A 1972  GLY A 1986  1                                  15    
HELIX   84 AJ3 ASN A 1992  ILE A 1997  5                                   6    
HELIX   85 AJ4 ASN A 2001  ILE A 2011  1                                  11    
HELIX   86 AJ5 THR A 2015  LEU A 2022  1                                   8    
HELIX   87 AJ6 GLU A 2023  LEU A 2031  1                                   9    
HELIX   88 AJ7 THR A 2034  TYR A 2048  1                                  15    
HELIX   89 AJ8 GLU C 2151  THR C 2160  1                                  10    
HELIX   90 AJ9 LEU C 2161  LEU C 2166  1                                   6    
HELIX   91 AK1 LYS C 2187  SER C 2197  1                                  11    
HELIX   92 AK2 ALA C 2270  ALA C 2282  1                                  13    
HELIX   93 AK3 THR C 2308  ASN C 2318  1                                  11    
HELIX   94 AK4 GLU C 2330  THR C 2332  5                                   3    
HELIX   95 AK5 MET C 2362  PHE C 2366  5                                   5    
HELIX   96 AK6 GLU B  118  THR B  128  1                                  11    
HELIX   97 AK7 PRO B  136  ILE B  148  1                                  13    
HELIX   98 AK8 ILE B  177  VAL B  186  1                                  10    
HELIX   99 AK9 PHE B  291  LEU B  301  1                                  11    
HELIX  100 AL1 ASP B  305  LEU B  323  1                                  19    
HELIX  101 AL2 ASN B  326  LYS B  339  1                                  14    
HELIX  102 AL3 ASN B  368  LYS B  376  1                                   9    
HELIX  103 AL4 ASP B  428  LYS B  433  1                                   6    
HELIX  104 AL5 TRP B  486  PHE B  491  5                                   6    
HELIX  105 AL6 ASN B  500  VAL B  506  1                                   7    
HELIX  106 AL7 VAL B  506  PHE B  511  1                                   6    
HELIX  107 AL8 LYS B  527  LEU B  539  1                                  13    
HELIX  108 AL9 LEU B  563  LEU B  578  1                                  16    
HELIX  109 AM1 LEU B  594  THR B  602  1                                   9    
HELIX  110 AM2 THR B  608  ASN B  618  1                                  11    
HELIX  111 AM3 ILE B  624  GLU B  626  5                                   3    
HELIX  112 AM4 ILE B  636  ASP B  641  5                                   6    
HELIX  113 AM5 ARG B  643  PHE B  655  1                                  13    
HELIX  114 AM6 ASN B  676  ARG B  685  1                                  10    
HELIX  115 AM7 ASP B  695  ARG B  699  5                                   5    
HELIX  116 AM8 LEU B  716  GLY B  737  1                                  22    
HELIX  117 AM9 SER B  746  GLU B  764  1                                  19    
HELIX  118 AN1 ILE B  766  THR B  771  1                                   6    
HELIX  119 AN2 ASP B  774  ALA B  786  1                                  13    
HELIX  120 AN3 ASP B  790  GLU B  798  1                                   9    
HELIX  121 AN4 THR B  809  ASP B  822  1                                  14    
HELIX  122 AN5 ALA B  832  ALA B  835  5                                   4    
HELIX  123 AN6 SER B  864  GLY B  873  1                                  10    
HELIX  124 AN7 ARG B  874  GLY B  876  5                                   3    
HELIX  125 AN8 ASN B  894  ASN B  903  1                                  10    
HELIX  126 AN9 LYS B  915  ALA B  926  1                                  12    
HELIX  127 AO1 CYS B  931  ALA B  940  1                                  10    
HELIX  128 AO2 THR B  942  SER B  951  1                                  10    
HELIX  129 AO3 ASP B  959  GLY B  964  1                                   6    
HELIX  130 AO4 LEU B  966  GLN B  984  1                                  19    
HELIX  131 AO5 THR B  999  PHE B 1008  1                                  10    
HELIX  132 AO6 ASN B 1011  LEU B 1022  1                                  12    
HELIX  133 AO7 THR B 1027  MET B 1037  1                                  11    
HELIX  134 AO8 SER B 1038  LYS B 1042  5                                   5    
HELIX  135 AO9 GLU B 1050  ALA B 1061  1                                  12    
HELIX  136 AP1 ASP B 1071  GLN B 1086  1                                  16    
HELIX  137 AP2 GLY B 1091  GLY B 1120  1                                  30    
HELIX  138 AP3 TRP B 1121  LYS B 1138  1                                  18    
HELIX  139 AP4 CYS B 1144  PHE B 1149  5                                   6    
HELIX  140 AP5 PRO B 1153  SER B 1163  1                                  11    
HELIX  141 AP6 PRO B 1166  LEU B 1173  5                                   8    
HELIX  142 AP7 THR B 1175  ILE B 1183  1                                   9    
HELIX  143 AP8 SER B 1185  LYS B 1187  5                                   3    
HELIX  144 AP9 TYR B 1188  PHE B 1199  1                                  12    
HELIX  145 AQ1 LYS B 1277  ASN B 1283  1                                   7    
HELIX  146 AQ2 SER B 1330  LEU B 1334  5                                   5    
HELIX  147 AQ3 ASN B 1336  VAL B 1342  1                                   7    
HELIX  148 AQ4 ASN B 1349  ASN B 1361  1                                  13    
HELIX  149 AQ5 LYS B 1376  GLN B 1390  1                                  15    
HELIX  150 AQ6 SER B 1401  PHE B 1416  1                                  16    
HELIX  151 AQ7 ASP B 1431  SER B 1442  1                                  12    
HELIX  152 AQ8 THR B 1448  SER B 1456  1                                   9    
HELIX  153 AQ9 ARG B 1462  SER B 1467  1                                   6    
HELIX  154 AR1 ALA B 1476  SER B 1480  5                                   5    
HELIX  155 AR2 GLN B 1481  GLU B 1503  1                                  23    
HELIX  156 AR3 ALA B 1518  GLY B 1526  1                                   9    
HELIX  157 AR4 ASN B 1560  ASN B 1577  1                                  18    
HELIX  158 AR5 SER B 1587  ILE B 1605  1                                  19    
HELIX  159 AR6 GLU B 1613  LYS B 1623  1                                  11    
HELIX  160 AR7 ASP B 1626  HIS B 1628  5                                   3    
HELIX  161 AR8 LEU B 1629  GLY B 1636  1                                   8    
HELIX  162 AR9 ALA B 1645  GLY B 1659  1                                  15    
HELIX  163 AS1 THR B 1699  GLY B 1708  1                                  10    
HELIX  164 AS2 HIS B 1726  GLU B 1738  1                                  13    
HELIX  165 AS3 TYR B 1745  TYR B 1748  5                                   4    
HELIX  166 AS4 ILE B 1749  ASN B 1760  1                                  12    
HELIX  167 AS5 SER B 1765  PHE B 1773  1                                   9    
HELIX  168 AS6 SER B 1776  ASN B 1785  1                                  10    
HELIX  169 AS7 SER B 1795  SER B 1817  1                                  23    
HELIX  170 AS8 LEU B 1847  GLY B 1857  1                                  11    
HELIX  171 AS9 SER B 1859  LEU B 1870  1                                  12    
HELIX  172 AT1 THR B 1875  THR B 1885  1                                  11    
HELIX  173 AT2 ALA B 1886  VAL B 1892  5                                   7    
HELIX  174 AT3 GLY B 1897  LYS B 1907  1                                  11    
HELIX  175 AT4 SER B 1921  ARG B 1936  1                                  16    
HELIX  176 AT5 PRO B 1940  GLY B 1969  1                                  30    
HELIX  177 AT6 ASN B 1972  GLY B 1986  1                                  15    
HELIX  178 AT7 ASN B 1992  ILE B 1997  5                                   6    
HELIX  179 AT8 ASN B 2001  ILE B 2011  1                                  11    
HELIX  180 AT9 THR B 2015  LEU B 2022  1                                   8    
HELIX  181 AU1 GLU B 2023  LEU B 2031  1                                   9    
HELIX  182 AU2 THR B 2034  ASN B 2047  1                                  14    
HELIX  183 AU3 ASN D 2150  ASN D 2159  1                                  10    
HELIX  184 AU4 THR D 2160  LYS D 2167  5                                   8    
HELIX  185 AU5 LYS D 2187  SER D 2197  1                                  11    
HELIX  186 AU6 ALA D 2270  ALA D 2282  1                                  13    
HELIX  187 AU7 THR D 2308  ASN D 2318  1                                  11    
HELIX  188 AU8 GLU D 2330  SER D 2334  5                                   5    
HELIX  189 AU9 MET D 2362  PHE D 2366  5                                   5    
HELIX  190 AV1 ARG D 2388  LEU D 2393  1                                   6    
SHEET    1 AA1 7 ASN A 267  LEU A 272  0                                        
SHEET    2 AA1 7 LEU A1544  GLN A1549 -1  O  ILE A1546   N  ILE A 270           
SHEET    3 AA1 7 GLY A1718  LEU A1723  1  O  ILE A1722   N  ASN A1547           
SHEET    4 AA1 7 GLU A1679  LEU A1683  1  N  ILE A1682   O  LEU A1721           
SHEET    5 AA1 7 SER A1581  LEU A1585  1  N  PHE A1584   O  ILE A1681           
SHEET    6 AA1 7 VAL A1663  SER A1667  1  O  ILE A1666   N  VAL A1583           
SHEET    7 AA1 7 VAL A1637  LEU A1640  1  N  GLY A1638   O  LEU A1665           
SHEET    1 AA2 8 PHE A 453  ARG A 455  0                                        
SHEET    2 AA2 8 TYR A 460  ILE A 465 -1  O  HIS A 464   N  PHE A 453           
SHEET    3 AA2 8 LEU A 703  ILE A 710 -1  O  GLY A 709   N  ASP A 461           
SHEET    4 AA2 8 GLY A 884  ASP A 891  1  O  THR A 890   N  ILE A 710           
SHEET    5 AA2 8 THR A 844  LYS A 848  1  N  VAL A 845   O  ILE A 887           
SHEET    6 AA2 8 ILE A 740  PHE A 743  1  N  ILE A 741   O  ILE A 846           
SHEET    7 AA2 8 VAL A 827  CYS A 830  1  O  LEU A 828   N  VAL A 742           
SHEET    8 AA2 8 GLY A 802  HIS A 804  1  N  GLY A 802   O  VAL A 827           
SHEET    1 AA3 7 LYS A 584  GLU A 587  0                                        
SHEET    2 AA3 7 GLN A 603  SER A 607  1  O  VAL A 606   N  ALA A 586           
SHEET    3 AA3 7 LYS A 556  ILE A 560  1  N  ILE A 557   O  LEU A 605           
SHEET    4 AA3 7 VAL A 628  ILE A 633  1  O  ILE A 632   N  ILE A 560           
SHEET    5 AA3 7 ARG A 666  SER A 671  1  O  ARG A 666   N  LEU A 631           
SHEET    6 AA3 7 MET A 517  CYS A 520  1  N  MET A 517   O  GLY A 669           
SHEET    7 AA3 7 LEU A 691  TYR A 693  1  O  PHE A 692   N  LEU A 518           
SHEET    1 AA4 2 ASP A 851  SER A 854  0                                        
SHEET    2 AA4 2 SER A 859  GLN A 862 -1  O  GLU A 861   N  VAL A 852           
SHEET    1 AA5 2 VAL A 987  ASP A 990  0                                        
SHEET    2 AA5 2 VAL A 995  ALA A 998 -1  O  GLU A 997   N  LEU A 988           
SHEET    1 AA6 3 MET A1202  PRO A1210  0                                        
SHEET    2 AA6 3 VAL A1215  ALA A1224 -1  O  ARG A1217   N  GLN A1209           
SHEET    3 AA6 3 GLU A1267  GLU A1275 -1  O  LEU A1270   N  ILE A1220           
SHEET    1 AA7 4 ILE A1251  ILE A1259  0                                        
SHEET    2 AA7 4 GLU A1237  GLU A1244 -1  N  LEU A1243   O  TYR A1253           
SHEET    3 AA7 4 ASN A1287  SER A1294 -1  O  ILE A1293   N  LEU A1240           
SHEET    4 AA7 4 ILE A1304  SER A1307 -1  O  ILE A1304   N  LEU A1290           
SHEET    1 AA8 6 VAL A1444  ALA A1447  0                                        
SHEET    2 AA8 6 ALA A1395  ILE A1398  1  N  TYR A1397   O  LEU A1445           
SHEET    3 AA8 6 LEU A1470  ASP A1474  1  O  ILE A1472   N  ILE A1398           
SHEET    4 AA8 6 ARG A1507  SER A1512  1  O  LEU A1511   N  TYR A1473           
SHEET    5 AA8 6 VAL A1366  GLY A1369  1  N  VAL A1368   O  SER A1512           
SHEET    6 AA8 6 ILE A1532  ASN A1534  1  O  TYR A1533   N  GLY A1369           
SHEET    1 AA9 2 ASN A1686  ASP A1689  0                                        
SHEET    2 AA9 2 LYS A1694  PRO A1697 -1  O  MET A1696   N  LEU A1687           
SHEET    1 AB1 2 ILE A1820  ASP A1823  0                                        
SHEET    2 AB1 2 ILE A1843  THR A1846 -1  O  SER A1845   N  GLU A1821           
SHEET    1 AB2 3 LEU A2053  LEU A2057  0                                        
SHEET    2 AB2 3 LYS A2068  THR A2076 -1  O  THR A2072   N  SER A2056           
SHEET    3 AB2 3 THR A2123  ASP A2131 -1  O  LEU A2128   N  ILE A2071           
SHEET    1 AB3 3 GLU A2110  ALA A2113  0                                        
SHEET    2 AB3 3 TRP A2099  GLU A2105 -1  N  LEU A2103   O  ALA A2113           
SHEET    3 AB3 3 LYS A2116  VAL A2117 -1  O  VAL A2117   N  TRP A2099           
SHEET    1 AB4 4 GLU A2110  ALA A2113  0                                        
SHEET    2 AB4 4 TRP A2099  GLU A2105 -1  N  LEU A2103   O  ALA A2113           
SHEET    3 AB4 4 LEU A2140  CYS A2146 -1  O  TRP A2143   N  VAL A2102           
SHEET    4 AB4 4 LYS A2154  PHE A2158 -1  O  PHE A2158   N  LEU A2140           
SHEET    1 AB5 8 ILE C2169  VAL C2171  0                                        
SHEET    2 AB5 8 VAL C2300  LEU C2307  1  O  LEU C2302   N  TYR C2170           
SHEET    3 AB5 8 ILE C2289  PHE C2294 -1  N  PHE C2294   O  SER C2301           
SHEET    4 AB5 8 GLU C2254  GLN C2262  1  N  LEU C2256   O  ILE C2289           
SHEET    5 AB5 8 ALA C2204  SER C2211 -1  N  ALA C2205   O  ILE C2259           
SHEET    6 AB5 8 VAL C2218  VAL C2225 -1  O  VAL C2225   N  PHE C2206           
SHEET    7 AB5 8 VAL C2182  PRO C2186  1  N  VAL C2184   O  ILE C2221           
SHEET    8 AB5 8 LEU C2340  SER C2342  1  O  LEU C2340   N  LEU C2185           
SHEET    1 AB6 8 SER C2334  HIS C2336  0                                        
SHEET    2 AB6 8 VAL C2300  LEU C2307 -1  N  ASN C2306   O  THR C2335           
SHEET    3 AB6 8 ILE C2289  PHE C2294 -1  N  PHE C2294   O  SER C2301           
SHEET    4 AB6 8 GLU C2254  GLN C2262  1  N  LEU C2256   O  ILE C2289           
SHEET    5 AB6 8 ALA C2204  SER C2211 -1  N  ALA C2205   O  ILE C2259           
SHEET    6 AB6 8 VAL C2218  VAL C2225 -1  O  VAL C2225   N  PHE C2206           
SHEET    7 AB6 8 ASN C2348  PRO C2352  1  O  ILE C2350   N  VAL C2224           
SHEET    8 AB6 8 PHE C2374  TYR C2376 -1  O  LYS C2375   N  ILE C2351           
SHEET    1 AB7 2 GLN C2229  HIS C2232  0                                        
SHEET    2 AB7 2 SER C2235  ILE C2238 -1  O  SER C2235   N  HIS C2232           
SHEET    1 AB8 7 GLU B 266  ILE B 269  0                                        
SHEET    2 AB8 7 LEU B1544  PHE B1551 -1  O  SER B1550   N  GLU B 266           
SHEET    3 AB8 7 GLY B1718  SER B1725  1  O  ILE B1722   N  ASN B1547           
SHEET    4 AB8 7 GLU B1679  LEU B1683  1  N  VAL B1680   O  LEU B1721           
SHEET    5 AB8 7 SER B1581  LEU B1585  1  N  PHE B1584   O  ILE B1681           
SHEET    6 AB8 7 VAL B1663  SER B1667  1  O  ILE B1666   N  LEU B1585           
SHEET    7 AB8 7 VAL B1637  LEU B1640  1  N  GLY B1638   O  LEU B1665           
SHEET    1 AB9 6 PHE B 453  VAL B 456  0                                        
SHEET    2 AB9 6 TYR B 460  HIS B 464 -1  O  GLU B 462   N  ARG B 455           
SHEET    3 AB9 6 LEU B 703  ILE B 710 -1  O  GLY B 709   N  ASP B 461           
SHEET    4 AB9 6 GLY B 884  ASP B 891  1  O  THR B 890   N  ILE B 710           
SHEET    5 AB9 6 THR B 844  LYS B 848  1  N  VAL B 845   O  ILE B 887           
SHEET    6 AB9 6 ILE B 740  PHE B 743  1  N  PHE B 743   O  ILE B 846           
SHEET    1 AC1 7 VAL B 585  GLU B 587  0                                        
SHEET    2 AC1 7 VAL B 604  SER B 607  1  O  VAL B 606   N  ALA B 586           
SHEET    3 AC1 7 LYS B 556  ILE B 560  1  N  TYR B 559   O  SER B 607           
SHEET    4 AC1 7 VAL B 628  ASP B 634  1  O  ILE B 632   N  ILE B 560           
SHEET    5 AC1 7 ARG B 666  SER B 671  1  O  ARG B 666   N  ARG B 629           
SHEET    6 AC1 7 MET B 517  CYS B 520  1  N  MET B 517   O  GLY B 669           
SHEET    7 AC1 7 LEU B 691  TYR B 693  1  O  PHE B 692   N  LEU B 518           
SHEET    1 AC2 2 GLY B 802  HIS B 804  0                                        
SHEET    2 AC2 2 LEU B 828  CYS B 830  1  O  VAL B 829   N  GLY B 802           
SHEET    1 AC3 2 VAL B 852  SER B 854  0                                        
SHEET    2 AC3 2 SER B 859  GLU B 861 -1  O  SER B 859   N  SER B 854           
SHEET    1 AC4 2 VAL B 987  ASP B 990  0                                        
SHEET    2 AC4 2 VAL B 995  ALA B 998 -1  O  GLU B 997   N  LEU B 988           
SHEET    1 AC5 3 MET B1202  PRO B1210  0                                        
SHEET    2 AC5 3 VAL B1215  ALA B1224 -1  O  ARG B1217   N  GLN B1209           
SHEET    3 AC5 3 GLU B1267  GLU B1275 -1  O  LEU B1270   N  ILE B1220           
SHEET    1 AC6 4 ILE B1251  ILE B1259  0                                        
SHEET    2 AC6 4 GLU B1237  GLU B1244 -1  N  LEU B1241   O  ASP B1255           
SHEET    3 AC6 4 ASN B1287  SER B1294 -1  O  ILE B1293   N  LEU B1240           
SHEET    4 AC6 4 ILE B1304  SER B1307 -1  O  ILE B1304   N  LEU B1290           
SHEET    1 AC7 6 VAL B1366  SER B1370  0                                        
SHEET    2 AC7 6 ARG B1507  ASN B1513  1  O  PHE B1508   N  VAL B1366           
SHEET    3 AC7 6 LEU B1470  ASP B1474  1  N  MET B1471   O  VAL B1509           
SHEET    4 AC7 6 ALA B1395  ILE B1398  1  N  ILE B1398   O  ILE B1472           
SHEET    5 AC7 6 VAL B1444  ALA B1447  1  O  LEU B1445   N  TYR B1397           
SHEET    6 AC7 6 ILE B1424  ASN B1426  1  N  ILE B1425   O  VAL B1444           
SHEET    1 AC8 2 ASN B1686  ASP B1689  0                                        
SHEET    2 AC8 2 LYS B1694  PRO B1697 -1  O  MET B1696   N  LEU B1687           
SHEET    1 AC9 2 ILE B1820  ASP B1823  0                                        
SHEET    2 AC9 2 ILE B1843  THR B1846 -1  O  SER B1845   N  GLU B1821           
SHEET    1 AD1 3 VAL B2051  SER B2056  0                                        
SHEET    2 AD1 3 LYS B2068  ARG B2077 -1  O  GLN B2074   N  THR B2054           
SHEET    3 AD1 3 THR B2123  ASP B2131 -1  O  LEU B2128   N  ILE B2071           
SHEET    1 AD2 4 GLU B2110  VAL B2117  0                                        
SHEET    2 AD2 4 TRP B2099  GLU B2105 -1  N  TRP B2099   O  VAL B2117           
SHEET    3 AD2 4 LEU B2140  CYS B2146 -1  O  TRP B2143   N  VAL B2102           
SHEET    4 AD2 4 LYS B2154  SER B2157 -1  O  LYS B2154   N  CYS B2144           
SHEET    1 AD3 2 GLY B2136  HIS B2138  0                                        
SHEET    2 AD3 2 ILE B2160  VAL B2162 -1  O  ILE B2160   N  HIS B2138           
SHEET    1 AD4 8 ILE D2169  VAL D2171  0                                        
SHEET    2 AD4 8 SER D2299  TYR D2305  1  O  LEU D2302   N  TYR D2170           
SHEET    3 AD4 8 ILE D2289  THR D2296 -1  N  PHE D2294   O  SER D2301           
SHEET    4 AD4 8 GLU D2254  GLN D2262  1  N  TRP D2258   O  ILE D2291           
SHEET    5 AD4 8 ALA D2204  SER D2211 -1  N  ALA D2205   O  ILE D2259           
SHEET    6 AD4 8 LYS D2219  VAL D2225 -1  O  VAL D2225   N  PHE D2206           
SHEET    7 AD4 8 TYR D2183  PRO D2186  1  N  VAL D2184   O  ILE D2221           
SHEET    8 AD4 8 LEU D2339  SER D2342  1  O  LEU D2340   N  LEU D2185           
SHEET    1 AD5 8 ILE D2169  VAL D2171  0                                        
SHEET    2 AD5 8 SER D2299  TYR D2305  1  O  LEU D2302   N  TYR D2170           
SHEET    3 AD5 8 ILE D2289  THR D2296 -1  N  PHE D2294   O  SER D2301           
SHEET    4 AD5 8 GLU D2254  GLN D2262  1  N  TRP D2258   O  ILE D2291           
SHEET    5 AD5 8 ALA D2204  SER D2211 -1  N  ALA D2205   O  ILE D2259           
SHEET    6 AD5 8 LYS D2219  VAL D2225 -1  O  VAL D2225   N  PHE D2206           
SHEET    7 AD5 8 ASN D2348  PRO D2352  1  O  ASN D2348   N  VAL D2224           
SHEET    8 AD5 8 PHE D2374  TYR D2376 -1  O  LYS D2375   N  ILE D2351           
SHEET    1 AD6 2 GLN D2229  HIS D2232  0                                        
SHEET    2 AD6 2 SER D2235  ILE D2238 -1  O  SER D2235   N  HIS D2232           
CRYST1  179.335  181.158  210.348  90.00  90.00  90.00 P 21 21 21    8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.005576  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.005520  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.004754        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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