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Database: PDB
Entry: 5T0I
LinkDB: 5T0I
Original site: 5T0I 
HEADER    HYDROLASE                               16-AUG-16   5T0I              
TITLE     STRUCTURAL BASIS FOR DYNAMIC REGULATION OF THE HUMAN 26S PROTEASOME   
CAVEAT     5T0I    ENTRY CONTAINS IMPROPER PEPTIDE LINKAGES. RESIDUE ARG K 20   
CAVEAT   2 5T0I    IS INCORRECTLY MODELED.                                      
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 7;                         
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT1,PROTEASOME 26S       
COMPND   5 SUBUNIT ATPASE 2,PROTEIN MSS1;                                       
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 4;                         
COMPND   8 CHAIN: B;                                                            
COMPND   9 SYNONYM: P26S4,26S PROTEASOME AAA-ATPASE SUBUNIT RPT2,PROTEASOME 26S 
COMPND  10 SUBUNIT ATPASE 1;                                                    
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 8;                         
COMPND  13 CHAIN: C;                                                            
COMPND  14 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT6,PROTEASOME 26S       
COMPND  15 SUBUNIT ATPASE 5,PROTEASOME SUBUNIT P45,THYROID HORMONE RECEPTOR-    
COMPND  16 INTERACTING PROTEIN 1,TRIP1,P45/SUG;                                 
COMPND  17 MOL_ID: 4;                                                           
COMPND  18 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 6B;                        
COMPND  19 CHAIN: D;                                                            
COMPND  20 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT3,MB67-INTERACTING     
COMPND  21 PROTEIN,MIP224,PROTEASOME 26S SUBUNIT ATPASE 4,TAT-BINDING PROTEIN 7,
COMPND  22 TBP-7;                                                               
COMPND  23 MOL_ID: 5;                                                           
COMPND  24 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 10B;                       
COMPND  25 CHAIN: E;                                                            
COMPND  26 MOL_ID: 6;                                                           
COMPND  27 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 6A;                        
COMPND  28 CHAIN: F;                                                            
COMPND  29 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT5,PROTEASOME 26S       
COMPND  30 SUBUNIT ATPASE 3,PROTEASOME SUBUNIT P50,TAT-BINDING PROTEIN 1,TBP-1; 
COMPND  31 MOL_ID: 7;                                                           
COMPND  32 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-6;                           
COMPND  33 CHAIN: G;                                                            
COMPND  34 SYNONYM: 27 KDA PROSOMAL PROTEIN,P27K,MACROPAIN IOTA CHAIN,          
COMPND  35 MULTICATALYTIC ENDOPEPTIDASE COMPLEX IOTA CHAIN,PROTEASOME IOTA      
COMPND  36 CHAIN;                                                               
COMPND  37 EC: 3.4.25.1;                                                        
COMPND  38 MOL_ID: 8;                                                           
COMPND  39 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-2;                           
COMPND  40 CHAIN: H;                                                            
COMPND  41 SYNONYM: MACROPAIN SUBUNIT C3,MULTICATALYTIC ENDOPEPTIDASE COMPLEX   
COMPND  42 SUBUNIT C3,PROTEASOME COMPONENT C3;                                  
COMPND  43 EC: 3.4.25.1;                                                        
COMPND  44 MOL_ID: 9;                                                           
COMPND  45 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-4;                           
COMPND  46 CHAIN: I;                                                            
COMPND  47 SYNONYM: MACROPAIN SUBUNIT C9,MULTICATALYTIC ENDOPEPTIDASE COMPLEX   
COMPND  48 SUBUNIT C9,PROTEASOME COMPONENT C9,PROTEASOME SUBUNIT L;             
COMPND  49 EC: 3.4.25.1;                                                        
COMPND  50 MOL_ID: 10;                                                          
COMPND  51 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-7;                           
COMPND  52 CHAIN: J;                                                            
COMPND  53 SYNONYM: PROTEASOME SUBUNIT RC6-1,PROTEASOME SUBUNIT XAPC7;          
COMPND  54 EC: 3.4.25.1;                                                        
COMPND  55 MOL_ID: 11;                                                          
COMPND  56 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-5;                           
COMPND  57 CHAIN: K;                                                            
COMPND  58 SYNONYM: MACROPAIN ZETA CHAIN,MULTICATALYTIC ENDOPEPTIDASE COMPLEX   
COMPND  59 ZETA CHAIN,PROTEASOME ZETA CHAIN;                                    
COMPND  60 EC: 3.4.25.1;                                                        
COMPND  61 MOL_ID: 12;                                                          
COMPND  62 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-1;                           
COMPND  63 CHAIN: L;                                                            
COMPND  64 SYNONYM: 30 KDA PROSOMAL PROTEIN,PROS-30,MACROPAIN SUBUNIT C2,       
COMPND  65 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C2,PROTEASOME COMPONENT 
COMPND  66 C2,PROTEASOME NU CHAIN;                                              
COMPND  67 EC: 3.4.25.1;                                                        
COMPND  68 MOL_ID: 13;                                                          
COMPND  69 MOLECULE: PROTEASOME SUBUNIT ALPHA TYPE-3;                           
COMPND  70 CHAIN: M;                                                            
COMPND  71 SYNONYM: MACROPAIN SUBUNIT C8,MULTICATALYTIC ENDOPEPTIDASE COMPLEX   
COMPND  72 SUBUNIT C8,PROTEASOME COMPONENT C8;                                  
COMPND  73 EC: 3.4.25.1;                                                        
COMPND  74 MOL_ID: 14;                                                          
COMPND  75 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-6;                            
COMPND  76 CHAIN: N;                                                            
COMPND  77 SYNONYM: MACROPAIN DELTA CHAIN,MULTICATALYTIC ENDOPEPTIDASE COMPLEX  
COMPND  78 DELTA CHAIN,PROTEASOME DELTA CHAIN,PROTEASOME SUBUNIT Y;             
COMPND  79 EC: 3.4.25.1;                                                        
COMPND  80 MOL_ID: 15;                                                          
COMPND  81 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-7;                            
COMPND  82 CHAIN: O;                                                            
COMPND  83 SYNONYM: MACROPAIN CHAIN Z,MULTICATALYTIC ENDOPEPTIDASE COMPLEX CHAIN
COMPND  84 Z,PROTEASOME SUBUNIT Z;                                              
COMPND  85 EC: 3.4.25.1;                                                        
COMPND  86 MOL_ID: 16;                                                          
COMPND  87 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-3;                            
COMPND  88 CHAIN: P;                                                            
COMPND  89 SYNONYM: PROTEASOME CHAIN 13,PROTEASOME COMPONENT C10-II,PROTEASOME  
COMPND  90 THETA CHAIN;                                                         
COMPND  91 EC: 3.4.25.1;                                                        
COMPND  92 MOL_ID: 17;                                                          
COMPND  93 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-2;                            
COMPND  94 CHAIN: Q;                                                            
COMPND  95 SYNONYM: MACROPAIN SUBUNIT C7-I,MULTICATALYTIC ENDOPEPTIDASE COMPLEX 
COMPND  96 SUBUNIT C7-I,PROTEASOME COMPONENT C7-I;                              
COMPND  97 EC: 3.4.25.1;                                                        
COMPND  98 MOL_ID: 18;                                                          
COMPND  99 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-5;                            
COMPND 100 CHAIN: R;                                                            
COMPND 101 SYNONYM: MACROPAIN EPSILON CHAIN,MULTICATALYTIC ENDOPEPTIDASE COMPLEX
COMPND 102 EPSILON CHAIN,PROTEASOME CHAIN 6,PROTEASOME EPSILON CHAIN,PROTEASOME 
COMPND 103 SUBUNIT MB1,PROTEASOME SUBUNIT X;                                    
COMPND 104 EC: 3.4.25.1;                                                        
COMPND 105 MOL_ID: 19;                                                          
COMPND 106 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-1;                            
COMPND 107 CHAIN: S;                                                            
COMPND 108 SYNONYM: MACROPAIN SUBUNIT C5,MULTICATALYTIC ENDOPEPTIDASE COMPLEX   
COMPND 109 SUBUNIT C5,PROTEASOME COMPONENT C5,PROTEASOME GAMMA CHAIN;           
COMPND 110 EC: 3.4.25.1;                                                        
COMPND 111 MOL_ID: 20;                                                          
COMPND 112 MOLECULE: PROTEASOME SUBUNIT BETA TYPE-4;                            
COMPND 113 CHAIN: T;                                                            
COMPND 114 SYNONYM: 26 KDA PROSOMAL PROTEIN,PROS-26,MACROPAIN BETA CHAIN,       
COMPND 115 MULTICATALYTIC ENDOPEPTIDASE COMPLEX BETA CHAIN,PROTEASOME BETA      
COMPND 116 CHAIN,PROTEASOME CHAIN 3,HSN3;                                       
COMPND 117 EC: 3.4.25.1;                                                        
COMPND 118 MOL_ID: 21;                                                          
COMPND 119 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1;            
COMPND 120 CHAIN: U;                                                            
COMPND 121 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN2,26S PROTEASOME       
COMPND 122 REGULATORY SUBUNIT S1,26S PROTEASOME SUBUNIT P112;                   
COMPND 123 MOL_ID: 22;                                                          
COMPND 124 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3;            
COMPND 125 CHAIN: V;                                                            
COMPND 126 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN3,26S PROTEASOME       
COMPND 127 REGULATORY SUBUNIT S3,PROTEASOME SUBUNIT P58;                        
COMPND 128 MOL_ID: 23;                                                          
COMPND 129 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12;           
COMPND 130 CHAIN: W;                                                            
COMPND 131 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN5,26S PROTEASOME       
COMPND 132 REGULATORY SUBUNIT P55;                                              
COMPND 133 MOL_ID: 24;                                                          
COMPND 134 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11;           
COMPND 135 CHAIN: X;                                                            
COMPND 136 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN6,26S PROTEASOME       
COMPND 137 REGULATORY SUBUNIT S9,26S PROTEASOME REGULATORY SUBUNIT P44.5;       
COMPND 138 MOL_ID: 25;                                                          
COMPND 139 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6;            
COMPND 140 CHAIN: Y;                                                            
COMPND 141 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN7,26S PROTEASOME       
COMPND 142 REGULATORY SUBUNIT S10,BREAST CANCER-ASSOCIATED PROTEIN SGA-113M,    
COMPND 143 PHOSPHONOFORMATE IMMUNO-ASSOCIATED PROTEIN 4,PROTEASOME REGULATORY   
COMPND 144 PARTICLE SUBUNIT P44S10,P42A;                                        
COMPND 145 MOL_ID: 26;                                                          
COMPND 146 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7;            
COMPND 147 CHAIN: Z;                                                            
COMPND 148 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN8,26S PROTEASOME       
COMPND 149 REGULATORY SUBUNIT S12,MOV34 PROTEIN HOMOLOG,PROTEASOME SUBUNIT P40; 
COMPND 150 MOL_ID: 27;                                                          
COMPND 151 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13;           
COMPND 152 CHAIN: a;                                                            
COMPND 153 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN9,26S PROTEASOME       
COMPND 154 REGULATORY SUBUNIT S11,26S PROTEASOME REGULATORY SUBUNIT P40.5;      
COMPND 155 MOL_ID: 28;                                                          
COMPND 156 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4;            
COMPND 157 CHAIN: b;                                                            
COMPND 158 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN10,26S PROTEASOME      
COMPND 159 REGULATORY SUBUNIT S5A,ANTISECRETORY FACTOR 1,ASF,MULTIUBIQUITIN     
COMPND 160 CHAIN-BINDING PROTEIN;                                               
COMPND 161 MOL_ID: 29;                                                          
COMPND 162 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14;           
COMPND 163 CHAIN: c;                                                            
COMPND 164 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN11,26S PROTEASOME-     
COMPND 165 ASSOCIATED PAD1 HOMOLOG 1;                                           
COMPND 166 EC: 3.4.19.-;                                                        
COMPND 167 MOL_ID: 30;                                                          
COMPND 168 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8;            
COMPND 169 CHAIN: d;                                                            
COMPND 170 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN12,26S PROTEASOME      
COMPND 171 REGULATORY SUBUNIT S14,P31;                                          
COMPND 172 MOL_ID: 31;                                                          
COMPND 173 MOLECULE: 26S PROTEASOME COMPLEX SUBUNIT DSS1;                       
COMPND 174 CHAIN: e;                                                            
COMPND 175 SYNONYM: DELETED IN SPLIT HAND/SPLIT FOOT PROTEIN 1,SPLIT HAND/FOOT  
COMPND 176 DELETED PROTEIN 1,SPLIT HAND/FOOT MALFORMATION TYPE 1 PROTEIN;       
COMPND 177 MOL_ID: 32;                                                          
COMPND 178 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2;            
COMPND 179 CHAIN: f;                                                            
COMPND 180 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN1,26S PROTEASOME       
COMPND 181 REGULATORY SUBUNIT S2,26S PROTEASOME SUBUNIT P97,PROTEIN 55.11,TUMOR 
COMPND 182 NECROSIS FACTOR TYPE 1 RECEPTOR-ASSOCIATED PROTEIN 2                 
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   7 ORGANISM_COMMON: HUMAN;                                              
SOURCE   8 ORGANISM_TAXID: 9606;                                                
SOURCE   9 MOL_ID: 3;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 MOL_ID: 4;                                                           
SOURCE  14 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  15 ORGANISM_COMMON: HUMAN;                                              
SOURCE  16 ORGANISM_TAXID: 9606;                                                
SOURCE  17 MOL_ID: 5;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 MOL_ID: 6;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  23 ORGANISM_COMMON: HUMAN;                                              
SOURCE  24 ORGANISM_TAXID: 9606;                                                
SOURCE  25 MOL_ID: 7;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 MOL_ID: 8;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  31 ORGANISM_COMMON: HUMAN;                                              
SOURCE  32 ORGANISM_TAXID: 9606;                                                
SOURCE  33 MOL_ID: 9;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  35 ORGANISM_COMMON: HUMAN;                                              
SOURCE  36 ORGANISM_TAXID: 9606;                                                
SOURCE  37 MOL_ID: 10;                                                          
SOURCE  38 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  39 ORGANISM_COMMON: HUMAN;                                              
SOURCE  40 ORGANISM_TAXID: 9606;                                                
SOURCE  41 MOL_ID: 11;                                                          
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 MOL_ID: 12;                                                          
SOURCE  46 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  47 ORGANISM_COMMON: HUMAN;                                              
SOURCE  48 ORGANISM_TAXID: 9606;                                                
SOURCE  49 MOL_ID: 13;                                                          
SOURCE  50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  51 ORGANISM_COMMON: HUMAN;                                              
SOURCE  52 ORGANISM_TAXID: 9606;                                                
SOURCE  53 MOL_ID: 14;                                                          
SOURCE  54 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  55 ORGANISM_COMMON: HUMAN;                                              
SOURCE  56 ORGANISM_TAXID: 9606;                                                
SOURCE  57 MOL_ID: 15;                                                          
SOURCE  58 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  59 ORGANISM_COMMON: HUMAN;                                              
SOURCE  60 ORGANISM_TAXID: 9606;                                                
SOURCE  61 MOL_ID: 16;                                                          
SOURCE  62 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  63 ORGANISM_COMMON: HUMAN;                                              
SOURCE  64 ORGANISM_TAXID: 9606;                                                
SOURCE  65 MOL_ID: 17;                                                          
SOURCE  66 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  67 ORGANISM_COMMON: HUMAN;                                              
SOURCE  68 ORGANISM_TAXID: 9606;                                                
SOURCE  69 MOL_ID: 18;                                                          
SOURCE  70 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  71 ORGANISM_COMMON: HUMAN;                                              
SOURCE  72 ORGANISM_TAXID: 9606;                                                
SOURCE  73 MOL_ID: 19;                                                          
SOURCE  74 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  75 ORGANISM_COMMON: HUMAN;                                              
SOURCE  76 ORGANISM_TAXID: 9606;                                                
SOURCE  77 MOL_ID: 20;                                                          
SOURCE  78 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  79 ORGANISM_COMMON: HUMAN;                                              
SOURCE  80 ORGANISM_TAXID: 9606;                                                
SOURCE  81 MOL_ID: 21;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  83 ORGANISM_COMMON: HUMAN;                                              
SOURCE  84 ORGANISM_TAXID: 9606;                                                
SOURCE  85 MOL_ID: 22;                                                          
SOURCE  86 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  87 ORGANISM_COMMON: HUMAN;                                              
SOURCE  88 ORGANISM_TAXID: 9606;                                                
SOURCE  89 MOL_ID: 23;                                                          
SOURCE  90 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  91 ORGANISM_COMMON: HUMAN;                                              
SOURCE  92 ORGANISM_TAXID: 9606;                                                
SOURCE  93 MOL_ID: 24;                                                          
SOURCE  94 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  95 ORGANISM_COMMON: HUMAN;                                              
SOURCE  96 ORGANISM_TAXID: 9606;                                                
SOURCE  97 MOL_ID: 25;                                                          
SOURCE  98 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  99 ORGANISM_COMMON: HUMAN;                                              
SOURCE 100 ORGANISM_TAXID: 9606;                                                
SOURCE 101 MOL_ID: 26;                                                          
SOURCE 102 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 103 ORGANISM_COMMON: HUMAN;                                              
SOURCE 104 ORGANISM_TAXID: 9606;                                                
SOURCE 105 MOL_ID: 27;                                                          
SOURCE 106 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 107 ORGANISM_COMMON: HUMAN;                                              
SOURCE 108 ORGANISM_TAXID: 9606;                                                
SOURCE 109 MOL_ID: 28;                                                          
SOURCE 110 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 111 ORGANISM_COMMON: HUMAN;                                              
SOURCE 112 ORGANISM_TAXID: 9606;                                                
SOURCE 113 MOL_ID: 29;                                                          
SOURCE 114 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 115 ORGANISM_COMMON: HUMAN;                                              
SOURCE 116 ORGANISM_TAXID: 9606;                                                
SOURCE 117 MOL_ID: 30;                                                          
SOURCE 118 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 119 ORGANISM_COMMON: HUMAN;                                              
SOURCE 120 ORGANISM_TAXID: 9606;                                                
SOURCE 121 MOL_ID: 31;                                                          
SOURCE 122 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 123 ORGANISM_COMMON: HUMAN;                                              
SOURCE 124 ORGANISM_TAXID: 9606;                                                
SOURCE 125 MOL_ID: 32;                                                          
SOURCE 126 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 127 ORGANISM_COMMON: HUMAN;                                              
SOURCE 128 ORGANISM_TAXID: 9606                                                 
KEYWDS    UBIQUITIN-PROTEASOME SYSTEM, AAA-ATPASE, HYDROLASE                    
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    S.CHEN,J.WU,Y.LU,Y.B.MA,B.H.LEE,Z.YU,Q.OUYANG,D.FINLEY,M.W.KIRSCHNER, 
AUTHOR   2 Y.MAO                                                                
REVDAT   3   30-NOV-16 5T0I    1       JRNL                                     
REVDAT   2   16-NOV-16 5T0I    1       JRNL                                     
REVDAT   1   19-OCT-16 5T0I    0                                                
JRNL        AUTH   S.CHEN,J.WU,Y.LU,Y.B.MA,B.H.LEE,Z.YU,Q.OUYANG,D.J.FINLEY,    
JRNL        AUTH 2 M.W.KIRSCHNER,Y.MAO                                          
JRNL        TITL   STRUCTURAL BASIS FOR DYNAMIC REGULATION OF THE HUMAN 26S     
JRNL        TITL 2 PROTEASOME.                                                  
JRNL        REF    PROC.NATL.ACAD.SCI.USA        V. 113 12991 2016              
JRNL        REFN                   ESSN 1091-6490                               
JRNL        PMID   27791164                                                     
JRNL        DOI    10.1073/PNAS.1614614113                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    8.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 8.000                          
REMARK   3   NUMBER OF PARTICLES               : NULL                           
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5T0I COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 26-AUG-16.                  
REMARK 100 THE DEPOSITION ID IS D_1000223434.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : NULL                              
REMARK 245   PARTICLE TYPE                  : NULL                              
REMARK 245   NAME OF SAMPLE                 : NULL                              
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : NULL                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI ARCTICA             
REMARK 245   DETECTOR TYPE                     : NULL                           
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : NULL                           
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 32-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N, O, P, Q, R, S,            
REMARK 350                    AND CHAINS: T, U, V, W, X, Y, Z, a, b, c,         
REMARK 350                    AND CHAINS: d, e, f                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     PRO A     2                                                      
REMARK 465     ASP A     3                                                      
REMARK 465     TYR A     4                                                      
REMARK 465     LEU A     5                                                      
REMARK 465     GLY A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     ASP A     8                                                      
REMARK 465     GLN A     9                                                      
REMARK 465     ARG A    10                                                      
REMARK 465     LYS A    11                                                      
REMARK 465     THR A    12                                                      
REMARK 465     LYS A    13                                                      
REMARK 465     GLU A    14                                                      
REMARK 465     ASP A    15                                                      
REMARK 465     GLU A    16                                                      
REMARK 465     LYS A    17                                                      
REMARK 465     ASP A    18                                                      
REMARK 465     ASP A    19                                                      
REMARK 465     LYS A    20                                                      
REMARK 465     PRO A    21                                                      
REMARK 465     ILE A    22                                                      
REMARK 465     ARG A    23                                                      
REMARK 465     ALA A    24                                                      
REMARK 465     LEU A    25                                                      
REMARK 465     ASP A    26                                                      
REMARK 465     GLU A    27                                                      
REMARK 465     GLY A    28                                                      
REMARK 465     ASP A    29                                                      
REMARK 465     ILE A    30                                                      
REMARK 465     ALA A    31                                                      
REMARK 465     LEU A    32                                                      
REMARK 465     LEU A    33                                                      
REMARK 465     LYS A    34                                                      
REMARK 465     THR A    35                                                      
REMARK 465     TYR A    36                                                      
REMARK 465     GLY A    37                                                      
REMARK 465     GLN A    38                                                      
REMARK 465     SER A    39                                                      
REMARK 465     THR A    40                                                      
REMARK 465     TYR A    41                                                      
REMARK 465     SER A    42                                                      
REMARK 465     ARG A    43                                                      
REMARK 465     GLN A    44                                                      
REMARK 465     ILE A    45                                                      
REMARK 465     LYS A    46                                                      
REMARK 465     GLN A    47                                                      
REMARK 465     VAL A    48                                                      
REMARK 465     GLU A    49                                                      
REMARK 465     ASP A    50                                                      
REMARK 465     ASP A    51                                                      
REMARK 465     ILE A    52                                                      
REMARK 465     GLN A    53                                                      
REMARK 465     GLN A    54                                                      
REMARK 465     LEU A    55                                                      
REMARK 465     LEU A    56                                                      
REMARK 465     LYS A    57                                                      
REMARK 465     LYS A    58                                                      
REMARK 465     ILE A    59                                                      
REMARK 465     ASN A    60                                                      
REMARK 465     GLU A    61                                                      
REMARK 465     LEU A    62                                                      
REMARK 465     THR A    63                                                      
REMARK 465     GLY A    64                                                      
REMARK 465     ILE A    65                                                      
REMARK 465     LYS A    66                                                      
REMARK 465     GLU A    67                                                      
REMARK 465     SER A    68                                                      
REMARK 465     ASP A    69                                                      
REMARK 465     THR A    70                                                      
REMARK 465     GLY A    71                                                      
REMARK 465     LEU A    72                                                      
REMARK 465     MET B     1                                                      
REMARK 465     GLY B     2                                                      
REMARK 465     GLN B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     GLN B     5                                                      
REMARK 465     SER B     6                                                      
REMARK 465     GLY B     7                                                      
REMARK 465     GLY B     8                                                      
REMARK 465     HIS B     9                                                      
REMARK 465     GLY B    10                                                      
REMARK 465     PRO B    11                                                      
REMARK 465     GLY B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     GLY B    14                                                      
REMARK 465     LYS B    15                                                      
REMARK 465     LYS B    16                                                      
REMARK 465     ASP B    17                                                      
REMARK 465     ASP B    18                                                      
REMARK 465     LYS B    19                                                      
REMARK 465     ASP B    20                                                      
REMARK 465     LYS B    21                                                      
REMARK 465     LYS B    22                                                      
REMARK 465     LYS B    23                                                      
REMARK 465     LYS B    24                                                      
REMARK 465     TYR B    25                                                      
REMARK 465     GLU B    26                                                      
REMARK 465     PRO B    27                                                      
REMARK 465     PRO B    28                                                      
REMARK 465     VAL B    29                                                      
REMARK 465     PRO B    30                                                      
REMARK 465     THR B    31                                                      
REMARK 465     ARG B    32                                                      
REMARK 465     VAL B    33                                                      
REMARK 465     GLY B    34                                                      
REMARK 465     LYS B    35                                                      
REMARK 465     LYS B    36                                                      
REMARK 465     LYS B    37                                                      
REMARK 465     LYS B    38                                                      
REMARK 465     LYS B    39                                                      
REMARK 465     THR B    40                                                      
REMARK 465     LYS B    41                                                      
REMARK 465     GLY B    42                                                      
REMARK 465     PRO B    43                                                      
REMARK 465     ASP B    44                                                      
REMARK 465     ALA B    45                                                      
REMARK 465     ALA B    46                                                      
REMARK 465     SER B    47                                                      
REMARK 465     LYS B    48                                                      
REMARK 465     LEU B    49                                                      
REMARK 465     PRO B    50                                                      
REMARK 465     LEU B    51                                                      
REMARK 465     VAL B    52                                                      
REMARK 465     THR B    53                                                      
REMARK 465     PRO B    54                                                      
REMARK 465     HIS B    55                                                      
REMARK 465     THR B    56                                                      
REMARK 465     GLN B    57                                                      
REMARK 465     CYS B    58                                                      
REMARK 465     ARG B    59                                                      
REMARK 465     LEU B    60                                                      
REMARK 465     LYS B    61                                                      
REMARK 465     LEU B    62                                                      
REMARK 465     LEU B    63                                                      
REMARK 465     LYS B    64                                                      
REMARK 465     LEU B    65                                                      
REMARK 465     GLU B    66                                                      
REMARK 465     ARG B    67                                                      
REMARK 465     ILE B    68                                                      
REMARK 465     LYS B    69                                                      
REMARK 465     ASP B    70                                                      
REMARK 465     TYR B    71                                                      
REMARK 465     LEU B    72                                                      
REMARK 465     LEU B    73                                                      
REMARK 465     MET B    74                                                      
REMARK 465     GLU B    75                                                      
REMARK 465     GLU B    76                                                      
REMARK 465     GLU B    77                                                      
REMARK 465     PHE B    78                                                      
REMARK 465     ILE B    79                                                      
REMARK 465     ARG B    80                                                      
REMARK 465     ASN B    81                                                      
REMARK 465     GLN B    82                                                      
REMARK 465     GLU B    83                                                      
REMARK 465     GLN B    84                                                      
REMARK 465     MET B    85                                                      
REMARK 465     LYS B    86                                                      
REMARK 465     PRO B    87                                                      
REMARK 465     LEU B    88                                                      
REMARK 465     GLU B    89                                                      
REMARK 465     GLU B    90                                                      
REMARK 465     LYS B    91                                                      
REMARK 465     GLN B    92                                                      
REMARK 465     MET C     9                                                      
REMARK 465     GLU C    10                                                      
REMARK 465     SER C   395                                                      
REMARK 465     GLU C   396                                                      
REMARK 465     LYS C   397                                                      
REMARK 465     ASN C   398                                                      
REMARK 465     MET C   399                                                      
REMARK 465     SER C   400                                                      
REMARK 465     ILE C   401                                                      
REMARK 465     LYS C   402                                                      
REMARK 465     LYS C   403                                                      
REMARK 465     LEU C   404                                                      
REMARK 465     TRP C   405                                                      
REMARK 465     LYS C   406                                                      
REMARK 465     MET D     1                                                      
REMARK 465     GLU D     2                                                      
REMARK 465     GLU D     3                                                      
REMARK 465     ILE D     4                                                      
REMARK 465     GLY D     5                                                      
REMARK 465     ILE D     6                                                      
REMARK 465     LEU D     7                                                      
REMARK 465     VAL D     8                                                      
REMARK 465     GLU D     9                                                      
REMARK 465     LYS D    10                                                      
REMARK 465     ALA D    11                                                      
REMARK 465     GLN D    12                                                      
REMARK 465     ASP D    13                                                      
REMARK 465     GLU D    14                                                      
REMARK 465     ILE D    15                                                      
REMARK 465     PRO D    16                                                      
REMARK 465     ALA D    17                                                      
REMARK 465     LEU D    18                                                      
REMARK 465     SER D    19                                                      
REMARK 465     VAL D    20                                                      
REMARK 465     SER D    21                                                      
REMARK 465     ARG D    22                                                      
REMARK 465     PRO D    23                                                      
REMARK 465     GLN D    24                                                      
REMARK 465     THR D    25                                                      
REMARK 465     GLY D    26                                                      
REMARK 465     LEU D    27                                                      
REMARK 465     SER D    28                                                      
REMARK 465     PHE D    29                                                      
REMARK 465     LEU D    30                                                      
REMARK 465     GLY D    31                                                      
REMARK 465     PRO D    32                                                      
REMARK 465     GLU D    33                                                      
REMARK 465     PRO D    34                                                      
REMARK 465     GLU D    35                                                      
REMARK 465     ASP D    36                                                      
REMARK 465     LEU D    37                                                      
REMARK 465     GLU D    38                                                      
REMARK 465     MET E   -13                                                      
REMARK 465     ALA E   -12                                                      
REMARK 465     ILE E   -11                                                      
REMARK 465     PRO E   -10                                                      
REMARK 465     GLY E    -9                                                      
REMARK 465     ILE E    -8                                                      
REMARK 465     PRO E    -7                                                      
REMARK 465     TYR E    -6                                                      
REMARK 465     GLU E    -5                                                      
REMARK 465     ARG E    -4                                                      
REMARK 465     ARG E    -3                                                      
REMARK 465     LEU E    -2                                                      
REMARK 465     LEU E    -1                                                      
REMARK 465     ILE E     0                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     ASP E     3                                                      
REMARK 465     PRO E     4                                                      
REMARK 465     ARG E     5                                                      
REMARK 465     ASP E     6                                                      
REMARK 465     LYS E     7                                                      
REMARK 465     ALA E     8                                                      
REMARK 465     LEU E     9                                                      
REMARK 465     GLN E    10                                                      
REMARK 465     ASP E    11                                                      
REMARK 465     TYR E    12                                                      
REMARK 465     ARG E    13                                                      
REMARK 465     LYS E    14                                                      
REMARK 465     LYS E    15                                                      
REMARK 465     LEU E    16                                                      
REMARK 465     LEU E    17                                                      
REMARK 465     GLU E    18                                                      
REMARK 465     HIS E    19                                                      
REMARK 465     LYS E    20                                                      
REMARK 465     GLU E    21                                                      
REMARK 465     ILE E    22                                                      
REMARK 465     ASP E    23                                                      
REMARK 465     GLY E    24                                                      
REMARK 465     ARG E    25                                                      
REMARK 465     LEU E    26                                                      
REMARK 465     LYS E    27                                                      
REMARK 465     GLU E    28                                                      
REMARK 465     LEU E    29                                                      
REMARK 465     ARG E    30                                                      
REMARK 465     GLU E    31                                                      
REMARK 465     GLN E    32                                                      
REMARK 465     LEU E    33                                                      
REMARK 465     LYS E    34                                                      
REMARK 465     GLU E    35                                                      
REMARK 465     LEU E    36                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ASN F     2                                                      
REMARK 465     LEU F     3                                                      
REMARK 465     LEU F     4                                                      
REMARK 465     PRO F     5                                                      
REMARK 465     ASN F     6                                                      
REMARK 465     ILE F     7                                                      
REMARK 465     GLU F     8                                                      
REMARK 465     SER F     9                                                      
REMARK 465     PRO F    10                                                      
REMARK 465     VAL F    11                                                      
REMARK 465     THR F    12                                                      
REMARK 465     ARG F    13                                                      
REMARK 465     GLN F    14                                                      
REMARK 465     GLU F    15                                                      
REMARK 465     LYS F    16                                                      
REMARK 465     MET F    17                                                      
REMARK 465     ALA F    18                                                      
REMARK 465     THR F    19                                                      
REMARK 465     VAL F    20                                                      
REMARK 465     TRP F    21                                                      
REMARK 465     ASP F    22                                                      
REMARK 465     GLU F    23                                                      
REMARK 465     ALA F    24                                                      
REMARK 465     GLU F    25                                                      
REMARK 465     GLN F    26                                                      
REMARK 465     ASP F    27                                                      
REMARK 465     GLY F    28                                                      
REMARK 465     ILE F    29                                                      
REMARK 465     GLY F    30                                                      
REMARK 465     GLU F    31                                                      
REMARK 465     GLU F    32                                                      
REMARK 465     VAL F    33                                                      
REMARK 465     LEU F    34                                                      
REMARK 465     LYS F    35                                                      
REMARK 465     MET F    36                                                      
REMARK 465     SER F    37                                                      
REMARK 465     THR F    38                                                      
REMARK 465     GLU F    39                                                      
REMARK 465     GLU F    40                                                      
REMARK 465     ILE F    41                                                      
REMARK 465     ILE F    42                                                      
REMARK 465     GLN F    43                                                      
REMARK 465     ARG F    44                                                      
REMARK 465     THR F    45                                                      
REMARK 465     ARG F    46                                                      
REMARK 465     LEU F    47                                                      
REMARK 465     LEU F    48                                                      
REMARK 465     ASP F    49                                                      
REMARK 465     SER F    50                                                      
REMARK 465     GLU F    51                                                      
REMARK 465     ILE F    52                                                      
REMARK 465     LYS F    53                                                      
REMARK 465     ILE F    54                                                      
REMARK 465     MET F    55                                                      
REMARK 465     LYS F    56                                                      
REMARK 465     SER F    57                                                      
REMARK 465     GLU F    58                                                      
REMARK 465     VAL F    59                                                      
REMARK 465     LEU F    60                                                      
REMARK 465     ARG F    61                                                      
REMARK 465     VAL F    62                                                      
REMARK 465     GLN F   104                                                      
REMARK 465     GLU F   105                                                      
REMARK 465     GLU F   106                                                      
REMARK 465     ASP F   107                                                      
REMARK 465     GLY F   108                                                      
REMARK 465     ALA F   109                                                      
REMARK 465     ASN F   110                                                      
REMARK 465     ILE F   111                                                      
REMARK 465     ASP F   112                                                      
REMARK 465     LEU F   113                                                      
REMARK 465     ASP F   114                                                      
REMARK 465     SER G     2                                                      
REMARK 465     ARG G     3                                                      
REMARK 465     GLY G     4                                                      
REMARK 465     ARG G   245                                                      
REMARK 465     ASP G   246                                                      
REMARK 465     LYS I   252                                                      
REMARK 465     GLU I   253                                                      
REMARK 465     LYS I   254                                                      
REMARK 465     GLU I   255                                                      
REMARK 465     GLN I   256                                                      
REMARK 465     LYS I   257                                                      
REMARK 465     GLU I   258                                                      
REMARK 465     LYS I   259                                                      
REMARK 465     ASP I   260                                                      
REMARK 465     LYS I   261                                                      
REMARK 465     LYS J   241                                                      
REMARK 465     LYS J   242                                                      
REMARK 465     LYS J   243                                                      
REMARK 465     GLN J   244                                                      
REMARK 465     LYS J   245                                                      
REMARK 465     LYS J   246                                                      
REMARK 465     ALA J   247                                                      
REMARK 465     SER J   248                                                      
REMARK 465     PHE K     2                                                      
REMARK 465     LEU K     3                                                      
REMARK 465     THR K     4                                                      
REMARK 465     ARG K     5                                                      
REMARK 465     SER K     6                                                      
REMARK 465     GLU K     7                                                      
REMARK 465     ALA K   128                                                      
REMARK 465     ASP K   129                                                      
REMARK 465     PRO K   130                                                      
REMARK 465     GLY K   131                                                      
REMARK 465     ALA K   132                                                      
REMARK 465     MET K   133                                                      
REMARK 465     GLN L    -4                                                      
REMARK 465     LEU L    -3                                                      
REMARK 465     SER L    -2                                                      
REMARK 465     LYS L    -1                                                      
REMARK 465     VAL L     0                                                      
REMARK 465     LYS L     1                                                      
REMARK 465     PHE L     2                                                      
REMARK 465     ARG L     3                                                      
REMARK 465     ARG L   242                                                      
REMARK 465     LYS L   243                                                      
REMARK 465     ALA L   244                                                      
REMARK 465     GLN L   245                                                      
REMARK 465     PRO L   246                                                      
REMARK 465     ALA L   247                                                      
REMARK 465     GLN L   248                                                      
REMARK 465     PRO L   249                                                      
REMARK 465     ALA L   250                                                      
REMARK 465     ASP L   251                                                      
REMARK 465     GLU L   252                                                      
REMARK 465     PRO L   253                                                      
REMARK 465     ALA L   254                                                      
REMARK 465     GLU L   255                                                      
REMARK 465     LYS L   256                                                      
REMARK 465     ALA L   257                                                      
REMARK 465     ASP L   258                                                      
REMARK 465     GLU L   259                                                      
REMARK 465     PRO L   260                                                      
REMARK 465     MET L   261                                                      
REMARK 465     GLU L   262                                                      
REMARK 465     HIS L   263                                                      
REMARK 465     SER M     1                                                      
REMARK 465     SER M     2                                                      
REMARK 465     ILE M     3                                                      
REMARK 465     GLY M     4                                                      
REMARK 465     GLU M   245                                                      
REMARK 465     GLU M   246                                                      
REMARK 465     ASP M   247                                                      
REMARK 465     GLU M   248                                                      
REMARK 465     SER M   249                                                      
REMARK 465     ASP M   250                                                      
REMARK 465     ASP M   251                                                      
REMARK 465     ASP M   252                                                      
REMARK 465     ASN M   253                                                      
REMARK 465     MET M   254                                                      
REMARK 465     ALA N   -32                                                      
REMARK 465     ALA N   -31                                                      
REMARK 465     THR N   -30                                                      
REMARK 465     LEU N   -29                                                      
REMARK 465     LEU N   -28                                                      
REMARK 465     ALA N   -27                                                      
REMARK 465     ALA N   -26                                                      
REMARK 465     ARG N   -25                                                      
REMARK 465     GLY N   -24                                                      
REMARK 465     ALA N   -23                                                      
REMARK 465     GLY N   -22                                                      
REMARK 465     PRO N   -21                                                      
REMARK 465     ALA N   -20                                                      
REMARK 465     PRO N   -19                                                      
REMARK 465     ALA N   -18                                                      
REMARK 465     TRP N   -17                                                      
REMARK 465     GLY N   -16                                                      
REMARK 465     PRO N   -15                                                      
REMARK 465     GLU N   -14                                                      
REMARK 465     ALA N   -13                                                      
REMARK 465     PHE N   -12                                                      
REMARK 465     THR N   -11                                                      
REMARK 465     PRO N   -10                                                      
REMARK 465     ASP N    -9                                                      
REMARK 465     TRP N    -8                                                      
REMARK 465     GLU N    -7                                                      
REMARK 465     SER N    -6                                                      
REMARK 465     ARG N    -5                                                      
REMARK 465     GLU N    -4                                                      
REMARK 465     VAL N    -3                                                      
REMARK 465     SER N    -2                                                      
REMARK 465     THR N    -1                                                      
REMARK 465     GLY N     0                                                      
REMARK 465     ASP N   192                                                      
REMARK 465     GLN N   193                                                      
REMARK 465     ILE N   194                                                      
REMARK 465     PRO N   195                                                      
REMARK 465     LYS N   196                                                      
REMARK 465     PHE N   197                                                      
REMARK 465     ALA N   198                                                      
REMARK 465     VAL N   199                                                      
REMARK 465     ALA N   200                                                      
REMARK 465     THR N   201                                                      
REMARK 465     LEU N   202                                                      
REMARK 465     PRO N   203                                                      
REMARK 465     PRO N   204                                                      
REMARK 465     ALA N   205                                                      
REMARK 465     ALA O   -41                                                      
REMARK 465     ALA O   -40                                                      
REMARK 465     VAL O   -39                                                      
REMARK 465     SER O   -38                                                      
REMARK 465     VAL O   -37                                                      
REMARK 465     TYR O   -36                                                      
REMARK 465     ALA O   -35                                                      
REMARK 465     PRO O   -34                                                      
REMARK 465     PRO O   -33                                                      
REMARK 465     VAL O   -32                                                      
REMARK 465     GLY O   -31                                                      
REMARK 465     GLY O   -30                                                      
REMARK 465     PHE O   -29                                                      
REMARK 465     SER O   -28                                                      
REMARK 465     PHE O   -27                                                      
REMARK 465     ASP O   -26                                                      
REMARK 465     ASN O   -25                                                      
REMARK 465     CYS O   -24                                                      
REMARK 465     ARG O   -23                                                      
REMARK 465     ARG O   -22                                                      
REMARK 465     ASN O   -21                                                      
REMARK 465     ALA O   -20                                                      
REMARK 465     VAL O   -19                                                      
REMARK 465     LEU O   -18                                                      
REMARK 465     GLU O   -17                                                      
REMARK 465     ALA O   -16                                                      
REMARK 465     ASP O   -15                                                      
REMARK 465     PHE O   -14                                                      
REMARK 465     ALA O   -13                                                      
REMARK 465     LYS O   -12                                                      
REMARK 465     ARG O   -11                                                      
REMARK 465     GLY O   -10                                                      
REMARK 465     TYR O    -9                                                      
REMARK 465     LYS O    -8                                                      
REMARK 465     LEU O    -7                                                      
REMARK 465     PRO O    -6                                                      
REMARK 465     LYS O    -5                                                      
REMARK 465     VAL O    -4                                                      
REMARK 465     ARG O    -3                                                      
REMARK 465     LYS O    -2                                                      
REMARK 465     THR O    -1                                                      
REMARK 465     GLY O     0                                                      
REMARK 465     ILE O   221                                                      
REMARK 465     GLU O   222                                                      
REMARK 465     VAL O   223                                                      
REMARK 465     LEU O   224                                                      
REMARK 465     GLU O   225                                                      
REMARK 465     GLU O   226                                                      
REMARK 465     THR O   227                                                      
REMARK 465     VAL O   228                                                      
REMARK 465     GLN O   229                                                      
REMARK 465     THR O   230                                                      
REMARK 465     MET O   231                                                      
REMARK 465     ASP O   232                                                      
REMARK 465     THR O   233                                                      
REMARK 465     SER O   234                                                      
REMARK 465     GLY Q   200                                                      
REMARK 465     SER Q   201                                                      
REMARK 465     ALA R   -57                                                      
REMARK 465     LEU R   -56                                                      
REMARK 465     ALA R   -55                                                      
REMARK 465     SER R   -54                                                      
REMARK 465     VAL R   -53                                                      
REMARK 465     LEU R   -52                                                      
REMARK 465     GLU R   -51                                                      
REMARK 465     ARG R   -50                                                      
REMARK 465     PRO R   -49                                                      
REMARK 465     LEU R   -48                                                      
REMARK 465     PRO R   -47                                                      
REMARK 465     VAL R   -46                                                      
REMARK 465     ASN R   -45                                                      
REMARK 465     GLN R   -44                                                      
REMARK 465     ARG R   -43                                                      
REMARK 465     GLY R   -42                                                      
REMARK 465     PHE R   -41                                                      
REMARK 465     PHE R   -40                                                      
REMARK 465     GLY R   -39                                                      
REMARK 465     LEU R   -38                                                      
REMARK 465     GLY R   -37                                                      
REMARK 465     GLY R   -36                                                      
REMARK 465     ARG R   -35                                                      
REMARK 465     ALA R   -34                                                      
REMARK 465     ASP R   -33                                                      
REMARK 465     LEU R   -32                                                      
REMARK 465     LEU R   -31                                                      
REMARK 465     ASP R   -30                                                      
REMARK 465     LEU R   -29                                                      
REMARK 465     GLY R   -28                                                      
REMARK 465     PRO R   -27                                                      
REMARK 465     GLY R   -26                                                      
REMARK 465     SER R   -25                                                      
REMARK 465     LEU R   -24                                                      
REMARK 465     SER R   -23                                                      
REMARK 465     ASP R   -22                                                      
REMARK 465     GLY R   -21                                                      
REMARK 465     LEU R   -20                                                      
REMARK 465     SER R   -19                                                      
REMARK 465     LEU R   -18                                                      
REMARK 465     ALA R   -17                                                      
REMARK 465     ALA R   -16                                                      
REMARK 465     PRO R   -15                                                      
REMARK 465     GLY R   -14                                                      
REMARK 465     TRP R   -13                                                      
REMARK 465     GLY R   -12                                                      
REMARK 465     VAL R   -11                                                      
REMARK 465     PRO R   -10                                                      
REMARK 465     GLU R    -9                                                      
REMARK 465     GLU R    -8                                                      
REMARK 465     PRO R    -7                                                      
REMARK 465     GLY R    -6                                                      
REMARK 465     ILE R    -5                                                      
REMARK 465     GLU R    -4                                                      
REMARK 465     MET R    -3                                                      
REMARK 465     LEU R    -2                                                      
REMARK 465     HIS R    -1                                                      
REMARK 465     GLY R     0                                                      
REMARK 465     SER R   202                                                      
REMARK 465     THR R   203                                                      
REMARK 465     PRO R   204                                                      
REMARK 465     LEU S   -26                                                      
REMARK 465     SER S   -25                                                      
REMARK 465     SER S   -24                                                      
REMARK 465     THR S   -23                                                      
REMARK 465     ALA S   -22                                                      
REMARK 465     MET S   -21                                                      
REMARK 465     TYR S   -20                                                      
REMARK 465     SER S   -19                                                      
REMARK 465     ALA S   -18                                                      
REMARK 465     PRO S   -17                                                      
REMARK 465     GLY S   -16                                                      
REMARK 465     ARG S   -15                                                      
REMARK 465     ASP S   -14                                                      
REMARK 465     LEU S   -13                                                      
REMARK 465     GLY S   -12                                                      
REMARK 465     MET S   -11                                                      
REMARK 465     GLU S   -10                                                      
REMARK 465     PRO S    -9                                                      
REMARK 465     HIS S    -8                                                      
REMARK 465     ARG S    -7                                                      
REMARK 465     ALA S    -6                                                      
REMARK 465     ALA S    -5                                                      
REMARK 465     GLY S    -4                                                      
REMARK 465     PRO S    -3                                                      
REMARK 465     LEU S    -2                                                      
REMARK 465     GLN S    -1                                                      
REMARK 465     LEU S     0                                                      
REMARK 465     GLU T   -43                                                      
REMARK 465     ALA T   -42                                                      
REMARK 465     PHE T   -41                                                      
REMARK 465     LEU T   -40                                                      
REMARK 465     GLY T   -39                                                      
REMARK 465     SER T   -38                                                      
REMARK 465     ARG T   -37                                                      
REMARK 465     SER T   -36                                                      
REMARK 465     GLY T   -35                                                      
REMARK 465     LEU T   -34                                                      
REMARK 465     TRP T   -33                                                      
REMARK 465     ALA T   -32                                                      
REMARK 465     GLY T   -31                                                      
REMARK 465     GLY T   -30                                                      
REMARK 465     PRO T   -29                                                      
REMARK 465     ALA T   -28                                                      
REMARK 465     PRO T   -27                                                      
REMARK 465     GLY T   -26                                                      
REMARK 465     GLN T   -25                                                      
REMARK 465     PHE T   -24                                                      
REMARK 465     TYR T   -23                                                      
REMARK 465     ARG T   -22                                                      
REMARK 465     ILE T   -21                                                      
REMARK 465     PRO T   -20                                                      
REMARK 465     SER T   -19                                                      
REMARK 465     THR T   -18                                                      
REMARK 465     PRO T   -17                                                      
REMARK 465     ASP T   -16                                                      
REMARK 465     SER T   -15                                                      
REMARK 465     PHE T   -14                                                      
REMARK 465     MET T   -13                                                      
REMARK 465     ASP T   -12                                                      
REMARK 465     PRO T   -11                                                      
REMARK 465     ALA T   -10                                                      
REMARK 465     SER T    -9                                                      
REMARK 465     ALA T    -8                                                      
REMARK 465     LEU T    -7                                                      
REMARK 465     TYR T    -6                                                      
REMARK 465     ARG T    -5                                                      
REMARK 465     GLY T    -4                                                      
REMARK 465     PRO T    -3                                                      
REMARK 465     ILE T    -2                                                      
REMARK 465     THR T    -1                                                      
REMARK 465     ARG T     0                                                      
REMARK 465     SER T   216                                                      
REMARK 465     GLY T   217                                                      
REMARK 465     PHE T   218                                                      
REMARK 465     GLU T   219                                                      
REMARK 465     MET U     1                                                      
REMARK 465     ILE U     2                                                      
REMARK 465     THR U     3                                                      
REMARK 465     SER U     4                                                      
REMARK 465     ALA U     5                                                      
REMARK 465     ALA U     6                                                      
REMARK 465     VAL U   271                                                      
REMARK 465     GLY U   272                                                      
REMARK 465     THR U   273                                                      
REMARK 465     PRO U   274                                                      
REMARK 465     ILE U   275                                                      
REMARK 465     ALA U   276                                                      
REMARK 465     SER U   277                                                      
REMARK 465     VAL U   278                                                      
REMARK 465     PRO U   279                                                      
REMARK 465     GLY U   280                                                      
REMARK 465     SER U   281                                                      
REMARK 465     THR U   282                                                      
REMARK 465     ASN U   283                                                      
REMARK 465     THR U   284                                                      
REMARK 465     GLY U   285                                                      
REMARK 465     THR U   286                                                      
REMARK 465     VAL U   287                                                      
REMARK 465     PRO U   288                                                      
REMARK 465     GLY U   289                                                      
REMARK 465     SER U   290                                                      
REMARK 465     GLU U   291                                                      
REMARK 465     LYS U   292                                                      
REMARK 465     ASP U   293                                                      
REMARK 465     SER U   294                                                      
REMARK 465     ASP U   295                                                      
REMARK 465     SER U   296                                                      
REMARK 465     MET U   297                                                      
REMARK 465     GLU U   298                                                      
REMARK 465     THR U   299                                                      
REMARK 465     GLU U   300                                                      
REMARK 465     GLU U   301                                                      
REMARK 465     LYS U   302                                                      
REMARK 465     THR U   303                                                      
REMARK 465     SER U   304                                                      
REMARK 465     SER U   305                                                      
REMARK 465     ALA U   306                                                      
REMARK 465     PHE U   307                                                      
REMARK 465     VAL U   308                                                      
REMARK 465     GLY U   309                                                      
REMARK 465     LYS U   310                                                      
REMARK 465     THR U   311                                                      
REMARK 465     PRO U   312                                                      
REMARK 465     GLU U   313                                                      
REMARK 465     ALA U   314                                                      
REMARK 465     SER U   315                                                      
REMARK 465     PRO U   316                                                      
REMARK 465     GLU U   317                                                      
REMARK 465     PRO U   318                                                      
REMARK 465     LYS U   319                                                      
REMARK 465     ALA U   815                                                      
REMARK 465     PRO U   816                                                      
REMARK 465     LEU U   817                                                      
REMARK 465     GLU U   818                                                      
REMARK 465     VAL U   819                                                      
REMARK 465     PRO U   820                                                      
REMARK 465     LYS U   821                                                      
REMARK 465     GLU U   822                                                      
REMARK 465     LYS U   823                                                      
REMARK 465     GLU U   824                                                      
REMARK 465     LYS U   825                                                      
REMARK 465     GLU U   826                                                      
REMARK 465     LYS U   827                                                      
REMARK 465     VAL U   828                                                      
REMARK 465     SER U   829                                                      
REMARK 465     THR U   830                                                      
REMARK 465     ALA U   831                                                      
REMARK 465     VAL U   832                                                      
REMARK 465     LEU U   833                                                      
REMARK 465     SER U   834                                                      
REMARK 465     ILE U   835                                                      
REMARK 465     GLU U   845                                                      
REMARK 465     LYS U   846                                                      
REMARK 465     GLU U   847                                                      
REMARK 465     LYS U   848                                                      
REMARK 465     LYS U   849                                                      
REMARK 465     GLU U   850                                                      
REMARK 465     GLU U   851                                                      
REMARK 465     GLU U   852                                                      
REMARK 465     LYS U   853                                                      
REMARK 465     MET U   854                                                      
REMARK 465     GLU U   855                                                      
REMARK 465     VAL U   856                                                      
REMARK 465     ASP U   857                                                      
REMARK 465     GLU U   858                                                      
REMARK 465     ALA U   859                                                      
REMARK 465     GLU U   860                                                      
REMARK 465     LYS U   861                                                      
REMARK 465     LYS U   862                                                      
REMARK 465     GLU U   863                                                      
REMARK 465     GLU U   864                                                      
REMARK 465     LYS U   865                                                      
REMARK 465     GLU U   866                                                      
REMARK 465     LYS U   867                                                      
REMARK 465     LYS U   868                                                      
REMARK 465     LYS U   869                                                      
REMARK 465     GLU U   870                                                      
REMARK 465     PRO U   871                                                      
REMARK 465     GLU U   872                                                      
REMARK 465     PRO U   873                                                      
REMARK 465     ASN U   874                                                      
REMARK 465     PHE U   875                                                      
REMARK 465     GLN U   876                                                      
REMARK 465     LEU U   877                                                      
REMARK 465     LEU U   878                                                      
REMARK 465     ASP U   879                                                      
REMARK 465     SER U   918                                                      
REMARK 465     GLU U   919                                                      
REMARK 465     ASP U   920                                                      
REMARK 465     ILE U   921                                                      
REMARK 465     GLU U   922                                                      
REMARK 465     GLU U   923                                                      
REMARK 465     LEU U   924                                                      
REMARK 465     VAL U   925                                                      
REMARK 465     GLU U   926                                                      
REMARK 465     PRO U   927                                                      
REMARK 465     VAL U   928                                                      
REMARK 465     ALA U   929                                                      
REMARK 465     ALA U   930                                                      
REMARK 465     HIS U   931                                                      
REMARK 465     GLY U   932                                                      
REMARK 465     PRO U   933                                                      
REMARK 465     LYS U   934                                                      
REMARK 465     ILE U   935                                                      
REMARK 465     GLU U   936                                                      
REMARK 465     GLU U   937                                                      
REMARK 465     GLU U   938                                                      
REMARK 465     GLU U   939                                                      
REMARK 465     GLN U   940                                                      
REMARK 465     GLU U   941                                                      
REMARK 465     PRO U   942                                                      
REMARK 465     GLU U   943                                                      
REMARK 465     PRO U   944                                                      
REMARK 465     PRO U   945                                                      
REMARK 465     GLU U   946                                                      
REMARK 465     PRO U   947                                                      
REMARK 465     PHE U   948                                                      
REMARK 465     GLU U   949                                                      
REMARK 465     TYR U   950                                                      
REMARK 465     ILE U   951                                                      
REMARK 465     ASP U   952                                                      
REMARK 465     ASP U   953                                                      
REMARK 465     LYS V     2                                                      
REMARK 465     GLN V     3                                                      
REMARK 465     GLU V     4                                                      
REMARK 465     GLY V     5                                                      
REMARK 465     SER V     6                                                      
REMARK 465     ALA V     7                                                      
REMARK 465     ARG V     8                                                      
REMARK 465     ARG V     9                                                      
REMARK 465     ARG V    10                                                      
REMARK 465     GLY V    11                                                      
REMARK 465     ALA V    12                                                      
REMARK 465     ASP V    13                                                      
REMARK 465     LYS V    14                                                      
REMARK 465     ALA V    15                                                      
REMARK 465     LYS V    16                                                      
REMARK 465     PRO V    17                                                      
REMARK 465     PRO V   498                                                      
REMARK 465     LYS V   499                                                      
REMARK 465     SER V   500                                                      
REMARK 465     TYR V   501                                                      
REMARK 465     ASN V   502                                                      
REMARK 465     LYS V   503                                                      
REMARK 465     ASP V   504                                                      
REMARK 465     LEU V   505                                                      
REMARK 465     GLU V   506                                                      
REMARK 465     SER V   507                                                      
REMARK 465     ALA V   508                                                      
REMARK 465     GLU V   509                                                      
REMARK 465     GLU V   510                                                      
REMARK 465     ARG V   511                                                      
REMARK 465     ARG V   512                                                      
REMARK 465     GLU V   513                                                      
REMARK 465     ARG V   514                                                      
REMARK 465     GLU V   515                                                      
REMARK 465     GLN V   516                                                      
REMARK 465     GLN V   517                                                      
REMARK 465     ASP V   518                                                      
REMARK 465     LEU V   519                                                      
REMARK 465     GLU V   520                                                      
REMARK 465     PHE V   521                                                      
REMARK 465     ALA V   522                                                      
REMARK 465     LYS V   523                                                      
REMARK 465     GLU V   524                                                      
REMARK 465     MET V   525                                                      
REMARK 465     ALA V   526                                                      
REMARK 465     GLU V   527                                                      
REMARK 465     ASP V   528                                                      
REMARK 465     ASP V   529                                                      
REMARK 465     ASP V   530                                                      
REMARK 465     ASP V   531                                                      
REMARK 465     SER V   532                                                      
REMARK 465     PHE V   533                                                      
REMARK 465     PRO V   534                                                      
REMARK 465     MET X     1                                                      
REMARK 465     ALA X     2                                                      
REMARK 465     ALA X     3                                                      
REMARK 465     ALA X     4                                                      
REMARK 465     ALA X     5                                                      
REMARK 465     VAL X     6                                                      
REMARK 465     VAL X     7                                                      
REMARK 465     GLU X     8                                                      
REMARK 465     PHE X     9                                                      
REMARK 465     GLN X    10                                                      
REMARK 465     ARG X    11                                                      
REMARK 465     ALA X    12                                                      
REMARK 465     GLN X    13                                                      
REMARK 465     SER X    14                                                      
REMARK 465     LEU X    15                                                      
REMARK 465     LEU X    16                                                      
REMARK 465     SER X    17                                                      
REMARK 465     THR X    18                                                      
REMARK 465     ASP X    19                                                      
REMARK 465     ARG X    20                                                      
REMARK 465     GLU X    21                                                      
REMARK 465     ALA X    22                                                      
REMARK 465     SER X    23                                                      
REMARK 465     ILE X    24                                                      
REMARK 465     ASP X    25                                                      
REMARK 465     ILE X    26                                                      
REMARK 465     LEU X    27                                                      
REMARK 465     HIS X    28                                                      
REMARK 465     SER X    29                                                      
REMARK 465     ILE X    30                                                      
REMARK 465     VAL X    31                                                      
REMARK 465     LYS X    32                                                      
REMARK 465     ARG X    33                                                      
REMARK 465     ASP X    34                                                      
REMARK 465     ILE X    35                                                      
REMARK 465     GLN X    36                                                      
REMARK 465     GLU X    37                                                      
REMARK 465     ASN X    38                                                      
REMARK 465     ASP X    39                                                      
REMARK 465     GLU X    40                                                      
REMARK 465     GLU X    41                                                      
REMARK 465     ALA X    42                                                      
REMARK 465     VAL X    43                                                      
REMARK 465     GLN X    44                                                      
REMARK 465     VAL X    45                                                      
REMARK 465     LYS X    46                                                      
REMARK 465     GLU X    47                                                      
REMARK 465     GLN X    48                                                      
REMARK 465     SER X    49                                                      
REMARK 465     ILE X    50                                                      
REMARK 465     LEU X    51                                                      
REMARK 465     GLU X    52                                                      
REMARK 465     LEU X    53                                                      
REMARK 465     GLY X    54                                                      
REMARK 465     SER X    55                                                      
REMARK 465     LEU X    56                                                      
REMARK 465     LEU X    57                                                      
REMARK 465     ALA X    58                                                      
REMARK 465     LYS X    59                                                      
REMARK 465     THR X    60                                                      
REMARK 465     GLY X    61                                                      
REMARK 465     GLN X    62                                                      
REMARK 465     ALA X    63                                                      
REMARK 465     ALA X    64                                                      
REMARK 465     GLU X    65                                                      
REMARK 465     LEU X    66                                                      
REMARK 465     GLY X    67                                                      
REMARK 465     GLY X    68                                                      
REMARK 465     LEU X    69                                                      
REMARK 465     LEU X    70                                                      
REMARK 465     LYS X    71                                                      
REMARK 465     TYR X    72                                                      
REMARK 465     VAL X    73                                                      
REMARK 465     ARG X    74                                                      
REMARK 465     PRO X    75                                                      
REMARK 465     PHE X    76                                                      
REMARK 465     LEU X    77                                                      
REMARK 465     ASN X    78                                                      
REMARK 465     SER X    79                                                      
REMARK 465     ILE X    80                                                      
REMARK 465     SER X    81                                                      
REMARK 465     LYS X    82                                                      
REMARK 465     ALA X    83                                                      
REMARK 465     LYS X    84                                                      
REMARK 465     ALA X    85                                                      
REMARK 465     ALA X    86                                                      
REMARK 465     ARG X    87                                                      
REMARK 465     LEU X    88                                                      
REMARK 465     VAL X    89                                                      
REMARK 465     ARG X    90                                                      
REMARK 465     SER X    91                                                      
REMARK 465     LEU X    92                                                      
REMARK 465     LEU X    93                                                      
REMARK 465     ASP X    94                                                      
REMARK 465     LEU X    95                                                      
REMARK 465     PHE X    96                                                      
REMARK 465     LEU X    97                                                      
REMARK 465     ASP X    98                                                      
REMARK 465     MET X    99                                                      
REMARK 465     GLU X   100                                                      
REMARK 465     ALA X   101                                                      
REMARK 465     ALA X   102                                                      
REMARK 465     THR X   103                                                      
REMARK 465     GLY X   104                                                      
REMARK 465     GLN X   105                                                      
REMARK 465     GLU X   106                                                      
REMARK 465     VAL X   107                                                      
REMARK 465     GLU X   108                                                      
REMARK 465     LEU X   109                                                      
REMARK 465     CYS X   110                                                      
REMARK 465     LEU X   111                                                      
REMARK 465     GLU X   112                                                      
REMARK 465     CYS X   113                                                      
REMARK 465     ILE X   114                                                      
REMARK 465     GLU X   115                                                      
REMARK 465     TRP X   116                                                      
REMARK 465     ALA X   117                                                      
REMARK 465     LYS X   118                                                      
REMARK 465     SER X   119                                                      
REMARK 465     GLU X   120                                                      
REMARK 465     LYS X   121                                                      
REMARK 465     ARG X   122                                                      
REMARK 465     THR X   123                                                      
REMARK 465     PHE X   124                                                      
REMARK 465     LEU X   125                                                      
REMARK 465     ARG X   126                                                      
REMARK 465     GLN X   127                                                      
REMARK 465     ALA X   128                                                      
REMARK 465     LEU X   129                                                      
REMARK 465     GLU X   130                                                      
REMARK 465     ALA X   131                                                      
REMARK 465     ARG X   132                                                      
REMARK 465     LEU X   133                                                      
REMARK 465     VAL X   134                                                      
REMARK 465     SER X   135                                                      
REMARK 465     LEU X   136                                                      
REMARK 465     TYR X   137                                                      
REMARK 465     PHE X   138                                                      
REMARK 465     ASP X   139                                                      
REMARK 465     THR X   140                                                      
REMARK 465     LYS X   141                                                      
REMARK 465     ARG X   142                                                      
REMARK 465     TYR X   143                                                      
REMARK 465     GLN X   144                                                      
REMARK 465     GLU X   145                                                      
REMARK 465     ALA X   146                                                      
REMARK 465     LEU X   147                                                      
REMARK 465     HIS X   148                                                      
REMARK 465     LEU X   149                                                      
REMARK 465     GLY X   150                                                      
REMARK 465     SER X   151                                                      
REMARK 465     GLN X   152                                                      
REMARK 465     LEU X   153                                                      
REMARK 465     LEU X   154                                                      
REMARK 465     ARG X   155                                                      
REMARK 465     GLU X   156                                                      
REMARK 465     LEU X   157                                                      
REMARK 465     LYS X   158                                                      
REMARK 465     LYS X   159                                                      
REMARK 465     MET X   160                                                      
REMARK 465     ASP X   161                                                      
REMARK 465     ASP X   162                                                      
REMARK 465     LYS X   163                                                      
REMARK 465     ALA X   164                                                      
REMARK 465     LEU X   165                                                      
REMARK 465     LEU X   166                                                      
REMARK 465     VAL X   167                                                      
REMARK 465     GLU X   168                                                      
REMARK 465     VAL X   169                                                      
REMARK 465     GLN X   170                                                      
REMARK 465     LEU X   171                                                      
REMARK 465     LEU X   172                                                      
REMARK 465     GLU X   173                                                      
REMARK 465     SER X   174                                                      
REMARK 465     LYS X   175                                                      
REMARK 465     THR X   176                                                      
REMARK 465     TYR X   177                                                      
REMARK 465     HIS X   178                                                      
REMARK 465     ALA X   179                                                      
REMARK 465     LEU X   180                                                      
REMARK 465     SER X   181                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     PRO Y     2                                                      
REMARK 465     LEU Y     3                                                      
REMARK 465     GLU Y     4                                                      
REMARK 465     ASN Y     5                                                      
REMARK 465     LEU Y     6                                                      
REMARK 465     GLU Y     7                                                      
REMARK 465     GLU Y     8                                                      
REMARK 465     GLU Y     9                                                      
REMARK 465     GLY Y    10                                                      
REMARK 465     LEU Y    11                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     PRO Z     2                                                      
REMARK 465     GLU Z     3                                                      
REMARK 465     LEU Z     4                                                      
REMARK 465     GLN Z   291                                                      
REMARK 465     GLU Z   292                                                      
REMARK 465     LYS Z   293                                                      
REMARK 465     GLU Z   294                                                      
REMARK 465     GLU Z   295                                                      
REMARK 465     SER Z   296                                                      
REMARK 465     LYS Z   297                                                      
REMARK 465     LYS Z   298                                                      
REMARK 465     ASP Z   299                                                      
REMARK 465     ARG Z   300                                                      
REMARK 465     LYS Z   301                                                      
REMARK 465     GLU Z   302                                                      
REMARK 465     ASP Z   303                                                      
REMARK 465     LYS Z   304                                                      
REMARK 465     GLU Z   305                                                      
REMARK 465     LYS Z   306                                                      
REMARK 465     ASP Z   307                                                      
REMARK 465     LYS Z   308                                                      
REMARK 465     ASP Z   309                                                      
REMARK 465     LYS Z   310                                                      
REMARK 465     GLU Z   311                                                      
REMARK 465     LYS Z   312                                                      
REMARK 465     SER Z   313                                                      
REMARK 465     ASP Z   314                                                      
REMARK 465     VAL Z   315                                                      
REMARK 465     LYS Z   316                                                      
REMARK 465     LYS Z   317                                                      
REMARK 465     GLU Z   318                                                      
REMARK 465     GLU Z   319                                                      
REMARK 465     LYS Z   320                                                      
REMARK 465     LYS Z   321                                                      
REMARK 465     GLU Z   322                                                      
REMARK 465     LYS Z   323                                                      
REMARK 465     LYS Z   324                                                      
REMARK 465     MET a     1                                                      
REMARK 465     LYS a     2                                                      
REMARK 465     ASP a     3                                                      
REMARK 465     GLU b   192                                                      
REMARK 465     GLY b   193                                                      
REMARK 465     GLY b   194                                                      
REMARK 465     ALA b   195                                                      
REMARK 465     MET b   196                                                      
REMARK 465     LEU b   197                                                      
REMARK 465     GLY b   198                                                      
REMARK 465     LEU b   199                                                      
REMARK 465     GLY b   200                                                      
REMARK 465     ALA b   201                                                      
REMARK 465     SER b   202                                                      
REMARK 465     ASP b   203                                                      
REMARK 465     PHE b   204                                                      
REMARK 465     GLU b   205                                                      
REMARK 465     PHE b   206                                                      
REMARK 465     GLY b   207                                                      
REMARK 465     VAL b   208                                                      
REMARK 465     ASP b   209                                                      
REMARK 465     PRO b   210                                                      
REMARK 465     SER b   211                                                      
REMARK 465     ALA b   212                                                      
REMARK 465     ASP b   213                                                      
REMARK 465     PRO b   214                                                      
REMARK 465     GLU b   215                                                      
REMARK 465     LEU b   216                                                      
REMARK 465     ALA b   217                                                      
REMARK 465     LEU b   218                                                      
REMARK 465     ALA b   219                                                      
REMARK 465     LEU b   220                                                      
REMARK 465     ARG b   221                                                      
REMARK 465     VAL b   222                                                      
REMARK 465     SER b   223                                                      
REMARK 465     MET b   224                                                      
REMARK 465     GLU b   225                                                      
REMARK 465     GLU b   226                                                      
REMARK 465     GLN b   227                                                      
REMARK 465     ARG b   228                                                      
REMARK 465     GLN b   229                                                      
REMARK 465     ARG b   230                                                      
REMARK 465     GLN b   231                                                      
REMARK 465     GLU b   232                                                      
REMARK 465     GLU b   233                                                      
REMARK 465     GLU b   234                                                      
REMARK 465     ALA b   235                                                      
REMARK 465     ARG b   236                                                      
REMARK 465     ARG b   237                                                      
REMARK 465     ALA b   238                                                      
REMARK 465     ALA b   239                                                      
REMARK 465     ALA b   240                                                      
REMARK 465     ALA b   241                                                      
REMARK 465     SER b   242                                                      
REMARK 465     ALA b   243                                                      
REMARK 465     ALA b   244                                                      
REMARK 465     GLU b   245                                                      
REMARK 465     ALA b   246                                                      
REMARK 465     GLY b   247                                                      
REMARK 465     ILE b   248                                                      
REMARK 465     ALA b   249                                                      
REMARK 465     THR b   250                                                      
REMARK 465     THR b   251                                                      
REMARK 465     GLY b   252                                                      
REMARK 465     THR b   253                                                      
REMARK 465     GLU b   254                                                      
REMARK 465     ASP b   255                                                      
REMARK 465     SER b   256                                                      
REMARK 465     ASP b   257                                                      
REMARK 465     ASP b   258                                                      
REMARK 465     ALA b   259                                                      
REMARK 465     LEU b   260                                                      
REMARK 465     LEU b   261                                                      
REMARK 465     LYS b   262                                                      
REMARK 465     MET b   263                                                      
REMARK 465     THR b   264                                                      
REMARK 465     ILE b   265                                                      
REMARK 465     SER b   266                                                      
REMARK 465     GLN b   267                                                      
REMARK 465     GLN b   268                                                      
REMARK 465     GLU b   269                                                      
REMARK 465     PHE b   270                                                      
REMARK 465     GLY b   271                                                      
REMARK 465     ARG b   272                                                      
REMARK 465     THR b   273                                                      
REMARK 465     GLY b   274                                                      
REMARK 465     LEU b   275                                                      
REMARK 465     PRO b   276                                                      
REMARK 465     ASP b   277                                                      
REMARK 465     LEU b   278                                                      
REMARK 465     SER b   279                                                      
REMARK 465     SER b   280                                                      
REMARK 465     MET b   281                                                      
REMARK 465     THR b   282                                                      
REMARK 465     GLU b   283                                                      
REMARK 465     GLU b   284                                                      
REMARK 465     GLU b   285                                                      
REMARK 465     GLN b   286                                                      
REMARK 465     ILE b   287                                                      
REMARK 465     ALA b   288                                                      
REMARK 465     TYR b   289                                                      
REMARK 465     ALA b   290                                                      
REMARK 465     MET b   291                                                      
REMARK 465     GLN b   292                                                      
REMARK 465     MET b   293                                                      
REMARK 465     SER b   294                                                      
REMARK 465     LEU b   295                                                      
REMARK 465     GLN b   296                                                      
REMARK 465     GLY b   297                                                      
REMARK 465     ALA b   298                                                      
REMARK 465     GLU b   299                                                      
REMARK 465     PHE b   300                                                      
REMARK 465     GLY b   301                                                      
REMARK 465     GLN b   302                                                      
REMARK 465     ALA b   303                                                      
REMARK 465     GLU b   304                                                      
REMARK 465     SER b   305                                                      
REMARK 465     ALA b   306                                                      
REMARK 465     ASP b   307                                                      
REMARK 465     ILE b   308                                                      
REMARK 465     ASP b   309                                                      
REMARK 465     ALA b   310                                                      
REMARK 465     SER b   311                                                      
REMARK 465     SER b   312                                                      
REMARK 465     ALA b   313                                                      
REMARK 465     MET b   314                                                      
REMARK 465     ASP b   315                                                      
REMARK 465     THR b   316                                                      
REMARK 465     SER b   317                                                      
REMARK 465     GLU b   318                                                      
REMARK 465     PRO b   319                                                      
REMARK 465     ALA b   320                                                      
REMARK 465     LYS b   321                                                      
REMARK 465     GLU b   322                                                      
REMARK 465     GLU b   323                                                      
REMARK 465     ASP b   324                                                      
REMARK 465     ASP b   325                                                      
REMARK 465     TYR b   326                                                      
REMARK 465     ASP b   327                                                      
REMARK 465     VAL b   328                                                      
REMARK 465     MET b   329                                                      
REMARK 465     GLN b   330                                                      
REMARK 465     ASP b   331                                                      
REMARK 465     PRO b   332                                                      
REMARK 465     GLU b   333                                                      
REMARK 465     PHE b   334                                                      
REMARK 465     LEU b   335                                                      
REMARK 465     GLN b   336                                                      
REMARK 465     SER b   337                                                      
REMARK 465     VAL b   338                                                      
REMARK 465     LEU b   339                                                      
REMARK 465     GLU b   340                                                      
REMARK 465     ASN b   341                                                      
REMARK 465     LEU b   342                                                      
REMARK 465     PRO b   343                                                      
REMARK 465     GLY b   344                                                      
REMARK 465     VAL b   345                                                      
REMARK 465     ASP b   346                                                      
REMARK 465     PRO b   347                                                      
REMARK 465     ASN b   348                                                      
REMARK 465     ASN b   349                                                      
REMARK 465     GLU b   350                                                      
REMARK 465     ALA b   351                                                      
REMARK 465     ILE b   352                                                      
REMARK 465     ARG b   353                                                      
REMARK 465     ASN b   354                                                      
REMARK 465     ALA b   355                                                      
REMARK 465     MET b   356                                                      
REMARK 465     GLY b   357                                                      
REMARK 465     SER b   358                                                      
REMARK 465     LEU b   359                                                      
REMARK 465     ALA b   360                                                      
REMARK 465     SER b   361                                                      
REMARK 465     GLN b   362                                                      
REMARK 465     ALA b   363                                                      
REMARK 465     THR b   364                                                      
REMARK 465     LYS b   365                                                      
REMARK 465     ASP b   366                                                      
REMARK 465     GLY b   367                                                      
REMARK 465     LYS b   368                                                      
REMARK 465     LYS b   369                                                      
REMARK 465     ASP b   370                                                      
REMARK 465     LYS b   371                                                      
REMARK 465     LYS b   372                                                      
REMARK 465     GLU b   373                                                      
REMARK 465     GLU b   374                                                      
REMARK 465     ASP b   375                                                      
REMARK 465     LYS b   376                                                      
REMARK 465     LYS b   377                                                      
REMARK 465     ASP c     2                                                      
REMARK 465     ARG c     3                                                      
REMARK 465     LEU c     4                                                      
REMARK 465     LEU c     5                                                      
REMARK 465     ARG c     6                                                      
REMARK 465     LEU c     7                                                      
REMARK 465     GLY c     8                                                      
REMARK 465     GLY c     9                                                      
REMARK 465     GLY c    10                                                      
REMARK 465     MET c    11                                                      
REMARK 465     PRO c    12                                                      
REMARK 465     GLY c    13                                                      
REMARK 465     LEU c    14                                                      
REMARK 465     GLY c    15                                                      
REMARK 465     GLN c    16                                                      
REMARK 465     GLY c    17                                                      
REMARK 465     PRO c    18                                                      
REMARK 465     PRO c    19                                                      
REMARK 465     THR c    20                                                      
REMARK 465     ASP c    21                                                      
REMARK 465     ALA c    22                                                      
REMARK 465     PRO c    23                                                      
REMARK 465     SER c   235                                                      
REMARK 465     GLU c   236                                                      
REMARK 465     HIS c   237                                                      
REMARK 465     CYS c   238                                                      
REMARK 465     LYS c   239                                                      
REMARK 465     HIS c   240                                                      
REMARK 465     ASN c   241                                                      
REMARK 465     GLU c   242                                                      
REMARK 465     SER c   243                                                      
REMARK 465     PHE d   -91                                                      
REMARK 465     ILE d   -90                                                      
REMARK 465     LYS d   -89                                                      
REMARK 465     GLY d   -88                                                      
REMARK 465     ARG d   -87                                                      
REMARK 465     ALA d   -86                                                      
REMARK 465     PRO d   -85                                                      
REMARK 465     ARG d   -84                                                      
REMARK 465     ALA d   -83                                                      
REMARK 465     PRO d   -82                                                      
REMARK 465     PRO d   -81                                                      
REMARK 465     ARG d   -80                                                      
REMARK 465     GLU d   -79                                                      
REMARK 465     ARG d   -78                                                      
REMARK 465     ARG d   -77                                                      
REMARK 465     ARG d   -76                                                      
REMARK 465     ALA d   -75                                                      
REMARK 465     THR d   -74                                                      
REMARK 465     ARG d   -73                                                      
REMARK 465     GLY d   -72                                                      
REMARK 465     GLY d   -71                                                      
REMARK 465     LEU d   -70                                                      
REMARK 465     ARG d   -69                                                      
REMARK 465     GLN d   -68                                                      
REMARK 465     VAL d   -67                                                      
REMARK 465     VAL d   -66                                                      
REMARK 465     ALA d   -65                                                      
REMARK 465     PRO d   -64                                                      
REMARK 465     PRO d   -63                                                      
REMARK 465     ARG d   -62                                                      
REMARK 465     ALA d   -61                                                      
REMARK 465     LEU d   -60                                                      
REMARK 465     GLY d   -59                                                      
REMARK 465     SER d   -58                                                      
REMARK 465     THR d   -57                                                      
REMARK 465     SER d   -56                                                      
REMARK 465     ARG d   -55                                                      
REMARK 465     PRO d   -54                                                      
REMARK 465     HIS d   -53                                                      
REMARK 465     PHE d   -52                                                      
REMARK 465     ARG d   -51                                                      
REMARK 465     ARG d   -50                                                      
REMARK 465     ALA d   -49                                                      
REMARK 465     SER d   -48                                                      
REMARK 465     VAL d   -47                                                      
REMARK 465     CYS d   -46                                                      
REMARK 465     ARG d   -45                                                      
REMARK 465     ARG d   -44                                                      
REMARK 465     ARG d   -43                                                      
REMARK 465     CYS d   -42                                                      
REMARK 465     ARG d   -41                                                      
REMARK 465     LYS d   -40                                                      
REMARK 465     SER d   -39                                                      
REMARK 465     GLY d   -38                                                      
REMARK 465     GLY d   -37                                                      
REMARK 465     LEU d   -36                                                      
REMARK 465     LEU d   -35                                                      
REMARK 465     ALA d   -34                                                      
REMARK 465     ALA d   -33                                                      
REMARK 465     SER d   -32                                                      
REMARK 465     ARG d   -31                                                      
REMARK 465     LYS d   -30                                                      
REMARK 465     MET d   -29                                                      
REMARK 465     ALA d   -28                                                      
REMARK 465     ALA d   -27                                                      
REMARK 465     ALA d   -26                                                      
REMARK 465     ALA d   -25                                                      
REMARK 465     VAL d   -24                                                      
REMARK 465     ASN d   -23                                                      
REMARK 465     GLY d   -22                                                      
REMARK 465     ALA d   -21                                                      
REMARK 465     ALA d   -20                                                      
REMARK 465     GLY d   -19                                                      
REMARK 465     PHE d   -18                                                      
REMARK 465     SER d   -17                                                      
REMARK 465     SER d   -16                                                      
REMARK 465     SER d   -15                                                      
REMARK 465     GLY d   -14                                                      
REMARK 465     PRO d   -13                                                      
REMARK 465     ALA d   -12                                                      
REMARK 465     ALA d   -11                                                      
REMARK 465     THR d   -10                                                      
REMARK 465     SER d    -9                                                      
REMARK 465     GLY d    -8                                                      
REMARK 465     ALA d    -7                                                      
REMARK 465     VAL d    -6                                                      
REMARK 465     LEU d    -5                                                      
REMARK 465     GLN d    -4                                                      
REMARK 465     ALA d    -3                                                      
REMARK 465     ALA d    -2                                                      
REMARK 465     THR d    -1                                                      
REMARK 465     GLY d     0                                                      
REMARK 465     LEU e    10                                                      
REMARK 465     GLY e    11                                                      
REMARK 465     LEU e    12                                                      
REMARK 465     LEU e    13                                                      
REMARK 465     GLU e    14                                                      
REMARK 465     GLU e    15                                                      
REMARK 465     ASP e    16                                                      
REMARK 465     ASP e    17                                                      
REMARK 465     GLU e    18                                                      
REMARK 465     PHE e    19                                                      
REMARK 465     GLU e    20                                                      
REMARK 465     GLU e    21                                                      
REMARK 465     PHE e    22                                                      
REMARK 465     PRO e    23                                                      
REMARK 465     ALA e    24                                                      
REMARK 465     GLU e    25                                                      
REMARK 465     ASP e    26                                                      
REMARK 465     TRP e    27                                                      
REMARK 465     ALA e    28                                                      
REMARK 465     GLY e    29                                                      
REMARK 465     LEU e    30                                                      
REMARK 465     ASP e    31                                                      
REMARK 465     GLU e    32                                                      
REMARK 465     ASP e    33                                                      
REMARK 465     GLU e    34                                                      
REMARK 465     ASP e    35                                                      
REMARK 465     ALA e    36                                                      
REMARK 465     HIS e    37                                                      
REMARK 465     VAL e    38                                                      
REMARK 465     TRP e    39                                                      
REMARK 465     GLY f   695                                                      
REMARK 465     GLN f   696                                                      
REMARK 465     ALA f   697                                                      
REMARK 465     GLY f   698                                                      
REMARK 465     LYS f   699                                                      
REMARK 465     PRO f   700                                                      
REMARK 465     LYS f   701                                                      
REMARK 465     THR f   702                                                      
REMARK 465     ILE f   703                                                      
REMARK 465     THR f   704                                                      
REMARK 465     GLY f   705                                                      
REMARK 465     PHE f   706                                                      
REMARK 465     GLN f   707                                                      
REMARK 465     THR f   708                                                      
REMARK 465     HIS f   709                                                      
REMARK 465     THR f   710                                                      
REMARK 465     THR f   711                                                      
REMARK 465     PRO f   712                                                      
REMARK 465     VAL f   713                                                      
REMARK 465     LEU f   714                                                      
REMARK 465     LEU f   715                                                      
REMARK 465     ALA f   716                                                      
REMARK 465     HIS f   717                                                      
REMARK 465     GLY f   718                                                      
REMARK 465     GLU f   719                                                      
REMARK 465     ARG f   720                                                      
REMARK 465     ALA f   721                                                      
REMARK 465     GLU f   722                                                      
REMARK 465     LEU f   723                                                      
REMARK 465     ALA f   724                                                      
REMARK 465     THR f   725                                                      
REMARK 465     GLU f   726                                                      
REMARK 465     GLU f   727                                                      
REMARK 465     PHE f   728                                                      
REMARK 465     LEU f   729                                                      
REMARK 465     PRO f   730                                                      
REMARK 465     VAL f   731                                                      
REMARK 465     THR f   732                                                      
REMARK 465     PRO f   733                                                      
REMARK 465     ILE f   734                                                      
REMARK 465     LEU f   735                                                      
REMARK 465     GLU f   736                                                      
REMARK 465     GLY f   737                                                      
REMARK 465     PHE f   738                                                      
REMARK 465     VAL f   739                                                      
REMARK 465     ILE f   740                                                      
REMARK 465     LEU f   741                                                      
REMARK 465     ARG f   742                                                      
REMARK 465     LYS f   743                                                      
REMARK 465     ASN f   744                                                      
REMARK 465     PRO f   745                                                      
REMARK 465     ASN f   746                                                      
REMARK 465     TYR f   747                                                      
REMARK 465     ASP f   748                                                      
REMARK 465     LEU f   749                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS G  45    CG   CD   CE   NZ                                   
REMARK 470     ASP G  46    CG   OD1  OD2                                       
REMARK 470     LYS G  55    CG   CD   CE   NZ                                   
REMARK 470     LYS G  59    CG   CD   CE   NZ                                   
REMARK 470     SER G  63    OG                                                  
REMARK 470     GLU G 146    CG   CD   OE1  OE2                                  
REMARK 470     LYS G 181    CG   CD   CE   NZ                                   
REMARK 470     LYS G 186    CG   CD   CE   NZ                                   
REMARK 470     PHE G 187    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP G 188    CG   OD1  OD2                                       
REMARK 470     GLU G 196    CG   CD   OE1  OE2                                  
REMARK 470     GLU G 223    CG   CD   OE1  OE2                                  
REMARK 470     LYS H  18    CG   CD   CE   NZ                                   
REMARK 470     VAL H  36    CG1  CG2                                            
REMARK 470     GLN H  52    CG   CD   OE1  NE2                                  
REMARK 470     LYS H  53    CG   CD   CE   NZ                                   
REMARK 470     SER H  54    OG                                                  
REMARK 470     ILE H  55    CG1  CG2  CD1                                       
REMARK 470     ARG H  60    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP H 139    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP H 139    CZ3  CH2                                            
REMARK 470     ASN H 140    CG   OD1  ND2                                       
REMARK 470     GLU H 141    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 143    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     MET H 163    CG   SD   CE                                        
REMARK 470     LYS H 176    CG   CD   CE   NZ                                   
REMARK 470     ARG H 177    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR H 178    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU H 184    CG   CD1  CD2                                       
REMARK 470     LEU H 193    CG   CD1  CD2                                       
REMARK 470     LEU H 195    CG   CD1  CD2                                       
REMARK 470     LYS H 196    CG   CD   CE   NZ                                   
REMARK 470     PHE H 199    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU H 200    CG   CD   OE1  OE2                                  
REMARK 470     GLN H 202    CG   CD   OE1  NE2                                  
REMARK 470     VAL H 226    CG1  CG2                                            
REMARK 470     LYS H 227    CG   CD   CE   NZ                                   
REMARK 470     LEU H 230    CG   CD1  CD2                                       
REMARK 470     ILE H 233    CG1  CG2  CD1                                       
REMARK 470     SER I  13    OG                                                  
REMARK 470     ILE I  37    CG1  CG2  CD1                                       
REMARK 470     ASN I  51    CG   OD1  ND2                                       
REMARK 470     ILE I  52    CG1  CG2  CD1                                       
REMARK 470     LYS I  54    CG   CD   CE   NZ                                   
REMARK 470     GLN I 177    CG   CD   OE1  NE2                                  
REMARK 470     MET I 184    CG   SD   CE                                        
REMARK 470     ILE I 194    CG1  CG2  CD1                                       
REMARK 470     MET I 201    CG   SD   CE                                        
REMARK 470     LYS I 205    CG   CD   CE   NZ                                   
REMARK 470     LYS I 210    CG   CD   CE   NZ                                   
REMARK 470     LYS I 222    CG   CD   CE   NZ                                   
REMARK 470     LYS I 229    CG   CD   CE   NZ                                   
REMARK 470     GLN I 230    CG   CD   OE1  NE2                                  
REMARK 470     LYS I 231    CG   CD   CE   NZ                                   
REMARK 470     GLU I 250    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 251    CG   CD   CE   NZ                                   
REMARK 470     LYS J  27    CG   CD   CE   NZ                                   
REMARK 470     ILE J  40    CG1  CG2  CD1                                       
REMARK 470     VAL J  42    CG1  CG2                                            
REMARK 470     GLU J  46    CG   CD   OE1  OE2                                  
REMARK 470     LYS J  47    CG   CD   CE   NZ                                   
REMARK 470     LYS J  48    CG   CD   CE   NZ                                   
REMARK 470     SER J  49    OG                                                  
REMARK 470     VAL J  50    CG1  CG2                                            
REMARK 470     LEU J  53    CG   CD1  CD2                                       
REMARK 470     PHE J 136    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE J 138    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR J 141    OG1  CG2                                            
REMARK 470     LYS J 157    CG   CD   CE   NZ                                   
REMARK 470     ARG J 163    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS J 166    CG   CD   CE   NZ                                   
REMARK 470     ARG J 169    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU J 170    CG   CD   OE1  OE2                                  
REMARK 470     LYS J 174    CG   CD   CE   NZ                                   
REMARK 470     ILE J 181    CG1  CG2  CD1                                       
REMARK 470     GLU J 182    CG   CD   OE1  OE2                                  
REMARK 470     THR J 183    OG1  CG2                                            
REMARK 470     ASP J 185    CG   OD1  OD2                                       
REMARK 470     THR J 187    OG1  CG2                                            
REMARK 470     LYS J 189    CG   CD   CE   NZ                                   
REMARK 470     ILE J 192    CG1  CG2  CD1                                       
REMARK 470     LYS J 193    CG   CD   CE   NZ                                   
REMARK 470     LEU J 195    CG   CD1  CD2                                       
REMARK 470     LEU J 196    CG   CD1  CD2                                       
REMARK 470     GLU J 197    CG   CD   OE1  OE2                                  
REMARK 470     VAL J 198    CG1  CG2                                            
REMARK 470     VAL J 199    CG1  CG2                                            
REMARK 470     LYS J 204    CG   CD   CE   NZ                                   
REMARK 470     GLU J 207    CG   CD   OE1  OE2                                  
REMARK 470     LEU J 208    CG   CD1  CD2                                       
REMARK 470     ARG J 212    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG J 213    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER J 216    OG                                                  
REMARK 470     LYS J 218    CG   CD   CE   NZ                                   
REMARK 470     GLU J 223    CG   CD   OE1  OE2                                  
REMARK 470     ILE J 225    CG1  CG2  CD1                                       
REMARK 470     GLU J 226    CG   CD   OE1  OE2                                  
REMARK 470     LYS J 227    CG   CD   CE   NZ                                   
REMARK 470     VAL J 229    CG1  CG2                                            
REMARK 470     ILE J 232    CG1  CG2  CD1                                       
REMARK 470     GLU J 233    CG   CD   OE1  OE2                                  
REMARK 470     LYS J 234    CG   CD   CE   NZ                                   
REMARK 470     GLU J 235    CG   CD   OE1  OE2                                  
REMARK 470     LYS J 236    CG   CD   CE   NZ                                   
REMARK 470     GLU J 237    CG   CD   OE1  OE2                                  
REMARK 470     ASN J 239    CG   OD1  ND2                                       
REMARK 470     GLU J 240    CG   CD   OE1  OE2                                  
REMARK 470     TYR K   8    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS K  86    CG   CD   CE   NZ                                   
REMARK 470     LYS K 187    CG   CD   CE   NZ                                   
REMARK 470     LYS K 192    CG   CD   CE   NZ                                   
REMARK 470     GLU K 208    CG   CD   OE1  OE2                                  
REMARK 470     LYS K 209    CG   CD   CE   NZ                                   
REMARK 470     LYS K 231    CG   CD   CE   NZ                                   
REMARK 470     LYS L 208    CG   CD   CE   NZ                                   
REMARK 470     LYS L 217    CG   CD   CE   NZ                                   
REMARK 470     ASP L 218    CG   OD1  OD2                                       
REMARK 470     GLU L 237    CG   CD   OE1  OE2                                  
REMARK 470     GLU L 238    CG   CD   OE1  OE2                                  
REMARK 470     GLN L 241    CG   CD   OE1  NE2                                  
REMARK 470     LYS M 109    CG   CD   CE   NZ                                   
REMARK 470     ASN M 143    CG   OD1  ND2                                       
REMARK 470     GLU M 203    CG   CD   OE1  OE2                                  
REMARK 470     LYS M 205    CG   CD   CE   NZ                                   
REMARK 470     LYS M 207    CG   CD   CE   NZ                                   
REMARK 470     ARG M 223    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS O   9    CG   CD   CE   NZ                                   
REMARK 470     LYS O 180    CG   CD   CE   NZ                                   
REMARK 470     LYS O 206    CG   CD   CE   NZ                                   
REMARK 470     GLU O 214    CG   CD   OE1  OE2                                  
REMARK 470     ARG P  48    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS Q  41    CG   CD   CE   NZ                                   
REMARK 470     ARG Q  95    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU Q 109    CG   CD   OE1  OE2                                  
REMARK 470     LYS Q 185    CG   CD   CE   NZ                                   
REMARK 470     LYS Q 198    CG   CD   CE   NZ                                   
REMARK 470     GLN Q 199    CG   CD   OE1  NE2                                  
REMARK 470     LYS R 106    CG   CD   CE   NZ                                   
REMARK 470     GLU R 150    CG   CD   OE1  OE2                                  
REMARK 470     ILE R 185    CG1  CG2  CD1                                       
REMARK 470     LYS S  45    CG   CD   CE   NZ                                   
REMARK 470     VAL S 161    CG1  CG2                                            
REMARK 470     LEU S 166    CG   CD1  CD2                                       
REMARK 470     LYS S 200    CG   CD   CE   NZ                                   
REMARK 470     ARG T  44    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS T 156    CG   CD   CE   NZ                                   
REMARK 470     LYS T 195    CG   CD   CE   NZ                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OD1  ASN a    13     CG   PRO a    19              1.95            
REMARK 500   O    SER G    63     OG1  THR G    67              2.11            
REMARK 500   O    LEU J   196     OG   SER J   201              2.12            
REMARK 500   O    GLN W   430     OG   SER W   434              2.14            
REMARK 500   O    SER V   415     OG   SER V   460              2.16            
REMARK 500   O    ASP W    59     OG1  THR W    63              2.16            
REMARK 500   NH2  ARG E   372     O    ALA M   168              2.16            
REMARK 500   OG1  THR P    58     O    LEU Q   121              2.17            
REMARK 500   ND2  ASN A   103     OD1  ASP F   169              2.17            
REMARK 500   ND2  ASN I   167     O    THR I   200              2.17            
REMARK 500   O    PHE U   773     OG   SER U   776              2.18            
REMARK 500   OG1  THR P    36     OD1  ASP P    38              2.18            
REMARK 500   O    LEU W   224     OG1  THR W   253              2.19            
REMARK 500   O    ASN W   440     OG1  THR W   443              2.19            
REMARK 500   OG   SER X   351     OG   SER X   357              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    TYR F 438   CG    TYR F 438   CD2     0.287                       
REMARK 500    TYR F 438   CG    TYR F 438   CD1     0.282                       
REMARK 500    TYR F 438   CD1   TYR F 438   CE1     0.578                       
REMARK 500    TYR F 438   CE1   TYR F 438   CZ      0.372                       
REMARK 500    TYR F 438   CZ    TYR F 438   CE2     0.374                       
REMARK 500    TYR F 438   CE2   TYR F 438   CD2     0.591                       
REMARK 500    ARG K  20   CB    ARG K  20   CG      1.732                       
REMARK 500    TYR V 212   CG    TYR V 212   CD2     0.298                       
REMARK 500    TYR V 212   CG    TYR V 212   CD1     0.296                       
REMARK 500    TYR V 212   CD1   TYR V 212   CE1     0.602                       
REMARK 500    TYR V 212   CE1   TYR V 212   CZ      0.382                       
REMARK 500    TYR V 212   CZ    TYR V 212   CE2     0.372                       
REMARK 500    TYR V 212   CE2   TYR V 212   CD2     0.605                       
REMARK 500    ARG c 104   C     PRO c 105   N       0.125                       
REMARK 500    LYS e   4   CD    LYS e   4   CE      1.684                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO B 227   C   -  N   -  CA  ANGL. DEV. =  11.1 DEGREES          
REMARK 500    ARG K  20   CA  -  CB  -  CG  ANGL. DEV. =  22.5 DEGREES          
REMARK 500    ARG K  20   CB  -  CG  -  CD  ANGL. DEV. =  21.6 DEGREES          
REMARK 500    LYS e   4   CG  -  CD  -  CE  ANGL. DEV. =  22.0 DEGREES          
REMARK 500    LYS e   4   CD  -  CE  -  NZ  ANGL. DEV. =  18.9 DEGREES          
REMARK 500    GLU f 459   N   -  CA  -  C   ANGL. DEV. =  16.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU A  93       -3.16     67.91                                   
REMARK 500    ASN A 103      -67.77   -128.81                                   
REMARK 500    PHE A 118       -7.25     84.09                                   
REMARK 500    TYR A 147       -1.58     68.43                                   
REMARK 500    HIS A 150      -75.27   -107.61                                   
REMARK 500    THR A 160     -143.52     48.80                                   
REMARK 500    VAL A 161      -13.72     61.82                                   
REMARK 500    LYS A 169      151.09     69.81                                   
REMARK 500    ASP A 171      161.98    175.88                                   
REMARK 500    VAL A 172       73.84     57.34                                   
REMARK 500    LYS A 181      -71.51   -102.82                                   
REMARK 500    VAL A 191      -62.12   -126.48                                   
REMARK 500    ILE A 206     -141.32     48.13                                   
REMARK 500    GLU A 207      138.98   -179.39                                   
REMARK 500    LYS A 222      -14.73     67.18                                   
REMARK 500    ASP A 234      -70.20   -128.72                                   
REMARK 500    LYS A 248     -124.15     42.61                                   
REMARK 500    LYS A 268     -143.42     49.99                                   
REMARK 500    GLU A 276       70.07     57.99                                   
REMARK 500    ARG A 284      -70.74   -113.89                                   
REMARK 500    PRO A 311       46.53   -102.67                                   
REMARK 500    VAL A 317     -141.70     45.30                                   
REMARK 500    LEU A 318      160.81    177.85                                   
REMARK 500    ASN A 322      -74.11   -101.13                                   
REMARK 500    ARG A 336      -65.09   -123.20                                   
REMARK 500    SER A 344       73.18     48.84                                   
REMARK 500    LEU A 345      147.58     66.92                                   
REMARK 500    MET A 362     -132.90     58.41                                   
REMARK 500    THR A 381     -139.35     50.66                                   
REMARK 500    ARG A 400       -2.23     68.51                                   
REMARK 500    LYS A 402      -73.22   -108.01                                   
REMARK 500    LYS B  98      -63.17    -99.15                                   
REMARK 500    ARG B 103      -61.89   -108.23                                   
REMARK 500    GLU B 113      -65.54   -109.85                                   
REMARK 500    ASN B 119       -6.40     82.60                                   
REMARK 500    PHE B 138      -12.82     69.91                                   
REMARK 500    LEU B 144      -71.57    -57.87                                   
REMARK 500    GLU B 145      150.90     70.43                                   
REMARK 500    LEU B 163      -75.14   -112.73                                   
REMARK 500    ASP B 168      162.21     67.14                                   
REMARK 500    VAL B 173      -71.24    -60.10                                   
REMARK 500    VAL B 176     -147.22     52.36                                   
REMARK 500    ALA B 179      150.31     68.48                                   
REMARK 500    ASP B 191      -61.35   -120.55                                   
REMARK 500    LEU B 205     -113.09     58.34                                   
REMARK 500    LYS B 217      148.43     64.02                                   
REMARK 500    PRO B 218       72.75   -104.30                                   
REMARK 500    PRO B 219       46.37    -87.35                                   
REMARK 500    ALA B 245     -133.65     57.84                                   
REMARK 500    SER B 253     -141.72     53.39                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     550 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 PRO A  311     ARG A  312                  -35.96                    
REMARK 500 VAL B  176     GLU B  177                  -30.31                    
REMARK 500 ALA B  278     PRO B  279                  123.83                    
REMARK 500 HIS C  171     PRO C  172                 -140.82                    
REMARK 500 GLY C  255     SER C  256                  149.13                    
REMARK 500 LEU V  101     PRO V  102                 -138.46                    
REMARK 500 HIS V  319     THR V  320                  -41.27                    
REMARK 500 GLN W  416     ARG W  417                  -35.06                    
REMARK 500 ASN Y  357     ARG Y  358                  -38.92                    
REMARK 500 ALA a  286     ASN a  287                  -32.78                    
REMARK 500 GLU d    3     GLN d    4                  -34.44                    
REMARK 500 GLU f  459     HIS f  460                  -30.37                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP A 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP D 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP E 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP F 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN c 401                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8336   RELATED DB: EMDB                              
REMARK 900 THE RP-CP SUBCOMPLEX IN THE SC STATE                                 
REMARK 900 RELATED ID: EMD-8332   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8333   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8334   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8335   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8337   RELATED DB: EMDB                              
REMARK 900 RELATED ID: 5T0C   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5T0G   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5T0H   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5T0J   RELATED DB: PDB                                   
DBREF  5T0I A    1   433  UNP    P35998   PRS7_HUMAN       1    433             
DBREF  5T0I B    1   440  UNP    P62191   PRS4_HUMAN       1    440             
DBREF  5T0I C    9   406  UNP    P62195   PRS8_HUMAN       9    406             
DBREF  5T0I D    1   418  UNP    P43686   PRS6B_HUMAN      1    418             
DBREF1 5T0I E  -13   389  UNP                  A0A087X2I1_HUMAN                 
DBREF2 5T0I E     A0A087X2I1                          1         403             
DBREF  5T0I F    1   439  UNP    P17980   PRS6A_HUMAN      1    439             
DBREF  5T0I G    2   246  UNP    P60900   PSA6_HUMAN       2    246             
DBREF  5T0I H    2   234  UNP    P25787   PSA2_HUMAN       2    234             
DBREF  5T0I I    2   261  UNP    P25789   PSA4_HUMAN       2    261             
DBREF  5T0I J    2   248  UNP    O14818   PSA7_HUMAN       2    248             
DBREF  5T0I K    2   241  UNP    P28066   PSA5_HUMAN       2    241             
DBREF  5T0I L   -4   263  UNP    P25786   PSA1_HUMAN       2    269             
DBREF  5T0I M    1   254  UNP    P25788   PSA3_HUMAN       2    255             
DBREF  5T0I N  -32   205  UNP    P28072   PSB6_HUMAN       2    239             
DBREF  5T0I O  -41   234  UNP    Q99436   PSB7_HUMAN       2    277             
DBREF  5T0I P    2   205  UNP    P49720   PSB3_HUMAN       2    205             
DBREF  5T0I Q    1   201  UNP    P49721   PSB2_HUMAN       1    201             
DBREF  5T0I R  -57   204  UNP    P28074   PSB5_HUMAN       2    263             
DBREF  5T0I S  -26   213  UNP    P20618   PSB1_HUMAN       2    241             
DBREF  5T0I T  -43   219  UNP    P28070   PSB4_HUMAN       2    264             
DBREF  5T0I U    1   953  UNP    Q99460   PSMD1_HUMAN      1    953             
DBREF  5T0I V    2   534  UNP    O43242   PSMD3_HUMAN      2    534             
DBREF  5T0I W    1   456  UNP    O00232   PSD12_HUMAN      1    456             
DBREF  5T0I X    1   422  UNP    O00231   PSD11_HUMAN      1    422             
DBREF  5T0I Y    1   389  UNP    Q15008   PSMD6_HUMAN      1    389             
DBREF  5T0I Z    1   324  UNP    P51665   PSMD7_HUMAN      1    324             
DBREF  5T0I a    1   376  UNP    Q9UNM6   PSD13_HUMAN      1    376             
DBREF  5T0I b    1   377  UNP    P55036   PSMD4_HUMAN      1    377             
DBREF  5T0I c    2   310  UNP    O00487   PSDE_HUMAN       2    310             
DBREF  5T0I d  -91   257  UNP    P48556   PSMD8_HUMAN      2    350             
DBREF  5T0I e    1    70  UNP    P60896   DSS1_HUMAN       1     70             
DBREF  5T0I f    1   749  UNP    Q13200   PSMD2_HUMAN      1    749             
SEQRES   1 A  433  MET PRO ASP TYR LEU GLY ALA ASP GLN ARG LYS THR LYS          
SEQRES   2 A  433  GLU ASP GLU LYS ASP ASP LYS PRO ILE ARG ALA LEU ASP          
SEQRES   3 A  433  GLU GLY ASP ILE ALA LEU LEU LYS THR TYR GLY GLN SER          
SEQRES   4 A  433  THR TYR SER ARG GLN ILE LYS GLN VAL GLU ASP ASP ILE          
SEQRES   5 A  433  GLN GLN LEU LEU LYS LYS ILE ASN GLU LEU THR GLY ILE          
SEQRES   6 A  433  LYS GLU SER ASP THR GLY LEU ALA PRO PRO ALA LEU TRP          
SEQRES   7 A  433  ASP LEU ALA ALA ASP LYS GLN THR LEU GLN SER GLU GLN          
SEQRES   8 A  433  PRO LEU GLN VAL ALA ARG CYS THR LYS ILE ILE ASN ALA          
SEQRES   9 A  433  ASP SER GLU ASP PRO LYS TYR ILE ILE ASN VAL LYS GLN          
SEQRES  10 A  433  PHE ALA LYS PHE VAL VAL ASP LEU SER ASP GLN VAL ALA          
SEQRES  11 A  433  PRO THR ASP ILE GLU GLU GLY MET ARG VAL GLY VAL ASP          
SEQRES  12 A  433  ARG ASN LYS TYR GLN ILE HIS ILE PRO LEU PRO PRO LYS          
SEQRES  13 A  433  ILE ASP PRO THR VAL THR MET MET GLN VAL GLU GLU LYS          
SEQRES  14 A  433  PRO ASP VAL THR TYR SER ASP VAL GLY GLY CYS LYS GLU          
SEQRES  15 A  433  GLN ILE GLU LYS LEU ARG GLU VAL VAL GLU THR PRO LEU          
SEQRES  16 A  433  LEU HIS PRO GLU ARG PHE VAL ASN LEU GLY ILE GLU PRO          
SEQRES  17 A  433  PRO LYS GLY VAL LEU LEU PHE GLY PRO PRO GLY THR GLY          
SEQRES  18 A  433  LYS THR LEU CYS ALA ARG ALA VAL ALA ASN ARG THR ASP          
SEQRES  19 A  433  ALA CYS PHE ILE ARG VAL ILE GLY SER GLU LEU VAL GLN          
SEQRES  20 A  433  LYS TYR VAL GLY GLU GLY ALA ARG MET VAL ARG GLU LEU          
SEQRES  21 A  433  PHE GLU MET ALA ARG THR LYS LYS ALA CYS LEU ILE PHE          
SEQRES  22 A  433  PHE ASP GLU ILE ASP ALA ILE GLY GLY ALA ARG PHE ASP          
SEQRES  23 A  433  ASP GLY ALA GLY GLY ASP ASN GLU VAL GLN ARG THR MET          
SEQRES  24 A  433  LEU GLU LEU ILE ASN GLN LEU ASP GLY PHE ASP PRO ARG          
SEQRES  25 A  433  GLY ASN ILE LYS VAL LEU MET ALA THR ASN ARG PRO ASP          
SEQRES  26 A  433  THR LEU ASP PRO ALA LEU MET ARG PRO GLY ARG LEU ASP          
SEQRES  27 A  433  ARG LYS ILE GLU PHE SER LEU PRO ASP LEU GLU GLY ARG          
SEQRES  28 A  433  THR HIS ILE PHE LYS ILE HIS ALA ARG SER MET SER VAL          
SEQRES  29 A  433  GLU ARG ASP ILE ARG PHE GLU LEU LEU ALA ARG LEU CYS          
SEQRES  30 A  433  PRO ASN SER THR GLY ALA GLU ILE ARG SER VAL CYS THR          
SEQRES  31 A  433  GLU ALA GLY MET PHE ALA ILE ARG ALA ARG ARG LYS ILE          
SEQRES  32 A  433  ALA THR GLU LYS ASP PHE LEU GLU ALA VAL ASN LYS VAL          
SEQRES  33 A  433  ILE LYS SER TYR ALA LYS PHE SER ALA THR PRO ARG TYR          
SEQRES  34 A  433  MET THR TYR ASN                                              
SEQRES   1 B  440  MET GLY GLN SER GLN SER GLY GLY HIS GLY PRO GLY GLY          
SEQRES   2 B  440  GLY LYS LYS ASP ASP LYS ASP LYS LYS LYS LYS TYR GLU          
SEQRES   3 B  440  PRO PRO VAL PRO THR ARG VAL GLY LYS LYS LYS LYS LYS          
SEQRES   4 B  440  THR LYS GLY PRO ASP ALA ALA SER LYS LEU PRO LEU VAL          
SEQRES   5 B  440  THR PRO HIS THR GLN CYS ARG LEU LYS LEU LEU LYS LEU          
SEQRES   6 B  440  GLU ARG ILE LYS ASP TYR LEU LEU MET GLU GLU GLU PHE          
SEQRES   7 B  440  ILE ARG ASN GLN GLU GLN MET LYS PRO LEU GLU GLU LYS          
SEQRES   8 B  440  GLN GLU GLU GLU ARG SER LYS VAL ASP ASP LEU ARG GLY          
SEQRES   9 B  440  THR PRO MET SER VAL GLY THR LEU GLU GLU ILE ILE ASP          
SEQRES  10 B  440  ASP ASN HIS ALA ILE VAL SER THR SER VAL GLY SER GLU          
SEQRES  11 B  440  HIS TYR VAL SER ILE LEU SER PHE VAL ASP LYS ASP LEU          
SEQRES  12 B  440  LEU GLU PRO GLY CYS SER VAL LEU LEU ASN HIS LYS VAL          
SEQRES  13 B  440  HIS ALA VAL ILE GLY VAL LEU MET ASP ASP THR ASP PRO          
SEQRES  14 B  440  LEU VAL THR VAL MET LYS VAL GLU LYS ALA PRO GLN GLU          
SEQRES  15 B  440  THR TYR ALA ASP ILE GLY GLY LEU ASP ASN GLN ILE GLN          
SEQRES  16 B  440  GLU ILE LYS GLU SER VAL GLU LEU PRO LEU THR HIS PRO          
SEQRES  17 B  440  GLU TYR TYR GLU GLU MET GLY ILE LYS PRO PRO LYS GLY          
SEQRES  18 B  440  VAL ILE LEU TYR GLY PRO PRO GLY THR GLY LYS THR LEU          
SEQRES  19 B  440  LEU ALA LYS ALA VAL ALA ASN GLN THR SER ALA THR PHE          
SEQRES  20 B  440  LEU ARG VAL VAL GLY SER GLU LEU ILE GLN LYS TYR LEU          
SEQRES  21 B  440  GLY ASP GLY PRO LYS LEU VAL ARG GLU LEU PHE ARG VAL          
SEQRES  22 B  440  ALA GLU GLU HIS ALA PRO SER ILE VAL PHE ILE ASP GLU          
SEQRES  23 B  440  ILE ASP ALA ILE GLY THR LYS ARG TYR ASP SER ASN SER          
SEQRES  24 B  440  GLY GLY GLU ARG GLU ILE GLN ARG THR MET LEU GLU LEU          
SEQRES  25 B  440  LEU ASN GLN LEU ASP GLY PHE ASP SER ARG GLY ASP VAL          
SEQRES  26 B  440  LYS VAL ILE MET ALA THR ASN ARG ILE GLU THR LEU ASP          
SEQRES  27 B  440  PRO ALA LEU ILE ARG PRO GLY ARG ILE ASP ARG LYS ILE          
SEQRES  28 B  440  GLU PHE PRO LEU PRO ASP GLU LYS THR LYS LYS ARG ILE          
SEQRES  29 B  440  PHE GLN ILE HIS THR SER ARG MET THR LEU ALA ASP ASP          
SEQRES  30 B  440  VAL THR LEU ASP ASP LEU ILE MET ALA LYS ASP ASP LEU          
SEQRES  31 B  440  SER GLY ALA ASP ILE LYS ALA ILE CYS THR GLU ALA GLY          
SEQRES  32 B  440  LEU MET ALA LEU ARG GLU ARG ARG MET LYS VAL THR ASN          
SEQRES  33 B  440  GLU ASP PHE LYS LYS SER LYS GLU ASN VAL LEU TYR LYS          
SEQRES  34 B  440  LYS GLN GLU GLY THR PRO GLU GLY LEU TYR LEU                  
SEQRES   1 C  398  MET GLU LEU GLU GLU GLY LYS ALA GLY SER GLY LEU ARG          
SEQRES   2 C  398  GLN TYR TYR LEU SER LYS ILE GLU GLU LEU GLN LEU ILE          
SEQRES   3 C  398  VAL ASN ASP LYS SER GLN ASN LEU ARG ARG LEU GLN ALA          
SEQRES   4 C  398  GLN ARG ASN GLU LEU ASN ALA LYS VAL ARG LEU LEU ARG          
SEQRES   5 C  398  GLU GLU LEU GLN LEU LEU GLN GLU GLN GLY SER TYR VAL          
SEQRES   6 C  398  GLY GLU VAL VAL ARG ALA MET ASP LYS LYS LYS VAL LEU          
SEQRES   7 C  398  VAL LYS VAL HIS PRO GLU GLY LYS PHE VAL VAL ASP VAL          
SEQRES   8 C  398  ASP LYS ASN ILE ASP ILE ASN ASP VAL THR PRO ASN CYS          
SEQRES   9 C  398  ARG VAL ALA LEU ARG ASN ASP SER TYR THR LEU HIS LYS          
SEQRES  10 C  398  ILE LEU PRO ASN LYS VAL ASP PRO LEU VAL SER LEU MET          
SEQRES  11 C  398  MET VAL GLU LYS VAL PRO ASP SER THR TYR GLU MET ILE          
SEQRES  12 C  398  GLY GLY LEU ASP LYS GLN ILE LYS GLU ILE LYS GLU VAL          
SEQRES  13 C  398  ILE GLU LEU PRO VAL LYS HIS PRO GLU LEU PHE GLU ALA          
SEQRES  14 C  398  LEU GLY ILE ALA GLN PRO LYS GLY VAL LEU LEU TYR GLY          
SEQRES  15 C  398  PRO PRO GLY THR GLY LYS THR LEU LEU ALA ARG ALA VAL          
SEQRES  16 C  398  ALA HIS HIS THR ASP CYS THR PHE ILE ARG VAL SER GLY          
SEQRES  17 C  398  SER GLU LEU VAL GLN LYS PHE ILE GLY GLU GLY ALA ARG          
SEQRES  18 C  398  MET VAL ARG GLU LEU PHE VAL MET ALA ARG GLU HIS ALA          
SEQRES  19 C  398  PRO SER ILE ILE PHE MET ASP GLU ILE ASP SER ILE GLY          
SEQRES  20 C  398  SER SER ARG LEU GLU GLY GLY SER GLY GLY ASP SER GLU          
SEQRES  21 C  398  VAL GLN ARG THR MET LEU GLU LEU LEU ASN GLN LEU ASP          
SEQRES  22 C  398  GLY PHE GLU ALA THR LYS ASN ILE LYS VAL ILE MET ALA          
SEQRES  23 C  398  THR ASN ARG ILE ASP ILE LEU ASP SER ALA LEU LEU ARG          
SEQRES  24 C  398  PRO GLY ARG ILE ASP ARG LYS ILE GLU PHE PRO PRO PRO          
SEQRES  25 C  398  ASN GLU GLU ALA ARG LEU ASP ILE LEU LYS ILE HIS SER          
SEQRES  26 C  398  ARG LYS MET ASN LEU THR ARG GLY ILE ASN LEU ARG LYS          
SEQRES  27 C  398  ILE ALA GLU LEU MET PRO GLY ALA SER GLY ALA GLU VAL          
SEQRES  28 C  398  LYS GLY VAL CYS THR GLU ALA GLY MET TYR ALA LEU ARG          
SEQRES  29 C  398  GLU ARG ARG VAL HIS VAL THR GLN GLU ASP PHE GLU MET          
SEQRES  30 C  398  ALA VAL ALA LYS VAL MET GLN LYS ASP SER GLU LYS ASN          
SEQRES  31 C  398  MET SER ILE LYS LYS LEU TRP LYS                              
SEQRES   1 D  418  MET GLU GLU ILE GLY ILE LEU VAL GLU LYS ALA GLN ASP          
SEQRES   2 D  418  GLU ILE PRO ALA LEU SER VAL SER ARG PRO GLN THR GLY          
SEQRES   3 D  418  LEU SER PHE LEU GLY PRO GLU PRO GLU ASP LEU GLU ASP          
SEQRES   4 D  418  LEU TYR SER ARG TYR LYS LYS LEU GLN GLN GLU LEU GLU          
SEQRES   5 D  418  PHE LEU GLU VAL GLN GLU GLU TYR ILE LYS ASP GLU GLN          
SEQRES   6 D  418  LYS ASN LEU LYS LYS GLU PHE LEU HIS ALA GLN GLU GLU          
SEQRES   7 D  418  VAL LYS ARG ILE GLN SER ILE PRO LEU VAL ILE GLY GLN          
SEQRES   8 D  418  PHE LEU GLU ALA VAL ASP GLN ASN THR ALA ILE VAL GLY          
SEQRES   9 D  418  SER THR THR GLY SER ASN TYR TYR VAL ARG ILE LEU SER          
SEQRES  10 D  418  THR ILE ASP ARG GLU LEU LEU LYS PRO ASN ALA SER VAL          
SEQRES  11 D  418  ALA LEU HIS LYS HIS SER ASN ALA LEU VAL ASP VAL LEU          
SEQRES  12 D  418  PRO PRO GLU ALA ASP SER SER ILE MET MET LEU THR SER          
SEQRES  13 D  418  ASP GLN LYS PRO ASP VAL MET TYR ALA ASP ILE GLY GLY          
SEQRES  14 D  418  MET ASP ILE GLN LYS GLN GLU VAL ARG GLU ALA VAL GLU          
SEQRES  15 D  418  LEU PRO LEU THR HIS PHE GLU LEU TYR LYS GLN ILE GLY          
SEQRES  16 D  418  ILE ASP PRO PRO ARG GLY VAL LEU MET TYR GLY PRO PRO          
SEQRES  17 D  418  GLY CYS GLY LYS THR MET LEU ALA LYS ALA VAL ALA HIS          
SEQRES  18 D  418  HIS THR THR ALA ALA PHE ILE ARG VAL VAL GLY SER GLU          
SEQRES  19 D  418  PHE VAL GLN LYS TYR LEU GLY GLU GLY PRO ARG MET VAL          
SEQRES  20 D  418  ARG ASP VAL PHE ARG LEU ALA LYS GLU ASN ALA PRO ALA          
SEQRES  21 D  418  ILE ILE PHE ILE ASP GLU ILE ASP ALA ILE ALA THR LYS          
SEQRES  22 D  418  ARG PHE ASP ALA GLN THR GLY ALA ASP ARG GLU VAL GLN          
SEQRES  23 D  418  ARG ILE LEU LEU GLU LEU LEU ASN GLN MET ASP GLY PHE          
SEQRES  24 D  418  ASP GLN ASN VAL ASN VAL LYS VAL ILE MET ALA THR ASN          
SEQRES  25 D  418  ARG ALA ASP THR LEU ASP PRO ALA LEU LEU ARG PRO GLY          
SEQRES  26 D  418  ARG LEU ASP ARG LYS ILE GLU PHE PRO LEU PRO ASP ARG          
SEQRES  27 D  418  ARG GLN LYS ARG LEU ILE PHE SER THR ILE THR SER LYS          
SEQRES  28 D  418  MET ASN LEU SER GLU GLU VAL ASP LEU GLU ASP TYR VAL          
SEQRES  29 D  418  ALA ARG PRO ASP LYS ILE SER GLY ALA ASP ILE ASN SER          
SEQRES  30 D  418  ILE CYS GLN GLU SER GLY MET LEU ALA VAL ARG GLU ASN          
SEQRES  31 D  418  ARG TYR ILE VAL LEU ALA LYS ASP PHE GLU LYS ALA TYR          
SEQRES  32 D  418  LYS THR VAL ILE LYS LYS ASP GLU GLN GLU HIS GLU PHE          
SEQRES  33 D  418  TYR LYS                                                      
SEQRES   1 E  403  MET ALA ILE PRO GLY ILE PRO TYR GLU ARG ARG LEU LEU          
SEQRES   2 E  403  ILE MET ALA ASP PRO ARG ASP LYS ALA LEU GLN ASP TYR          
SEQRES   3 E  403  ARG LYS LYS LEU LEU GLU HIS LYS GLU ILE ASP GLY ARG          
SEQRES   4 E  403  LEU LYS GLU LEU ARG GLU GLN LEU LYS GLU LEU THR LYS          
SEQRES   5 E  403  GLN TYR GLU LYS SER GLU ASN ASP LEU LYS ALA LEU GLN          
SEQRES   6 E  403  SER VAL GLY GLN ILE VAL GLY GLU VAL LEU LYS GLN LEU          
SEQRES   7 E  403  THR GLU GLU LYS PHE ILE VAL LYS ALA THR ASN GLY PRO          
SEQRES   8 E  403  ARG TYR VAL VAL GLY CYS ARG ARG GLN LEU ASP LYS SER          
SEQRES   9 E  403  LYS LEU LYS PRO GLY THR ARG VAL ALA LEU ASP MET THR          
SEQRES  10 E  403  THR LEU THR ILE MET ARG TYR LEU PRO ARG GLU VAL ASP          
SEQRES  11 E  403  PRO LEU VAL TYR ASN MET SER HIS GLU ASP PRO GLY ASN          
SEQRES  12 E  403  VAL SER TYR SER GLU ILE GLY GLY LEU SER GLU GLN ILE          
SEQRES  13 E  403  ARG GLU LEU ARG GLU VAL ILE GLU LEU PRO LEU THR ASN          
SEQRES  14 E  403  PRO GLU LEU PHE GLN ARG VAL GLY ILE ILE PRO PRO LYS          
SEQRES  15 E  403  GLY CYS LEU LEU TYR GLY PRO PRO GLY THR GLY LYS THR          
SEQRES  16 E  403  LEU LEU ALA ARG ALA VAL ALA SER GLN LEU ASP CYS ASN          
SEQRES  17 E  403  PHE LEU LYS VAL VAL SER SER SER ILE VAL ASP LYS TYR          
SEQRES  18 E  403  ILE GLY GLU SER ALA ARG LEU ILE ARG GLU MET PHE ASN          
SEQRES  19 E  403  TYR ALA ARG ASP HIS GLN PRO CYS ILE ILE PHE MET ASP          
SEQRES  20 E  403  GLU ILE ASP ALA ILE GLY GLY ARG ARG PHE SER GLU GLY          
SEQRES  21 E  403  THR SER ALA ASP ARG GLU ILE GLN ARG THR LEU MET GLU          
SEQRES  22 E  403  LEU LEU ASN GLN MET ASP GLY PHE ASP THR LEU HIS ARG          
SEQRES  23 E  403  VAL LYS MET ILE MET ALA THR ASN ARG PRO ASP THR LEU          
SEQRES  24 E  403  ASP PRO ALA LEU LEU ARG PRO GLY ARG LEU ASP ARG LYS          
SEQRES  25 E  403  ILE HIS ILE ASP LEU PRO ASN GLU GLN ALA ARG LEU ASP          
SEQRES  26 E  403  ILE LEU LYS ILE HIS ALA GLY PRO ILE THR LYS HIS GLY          
SEQRES  27 E  403  GLU ILE ASP TYR GLU ALA ILE VAL LYS LEU SER ASP GLY          
SEQRES  28 E  403  PHE ASN GLY ALA ASP LEU ARG ASN VAL CYS THR GLU ALA          
SEQRES  29 E  403  GLY MET PHE ALA ILE ARG ALA ASP HIS ASP PHE VAL VAL          
SEQRES  30 E  403  GLN GLU ASP PHE MET LYS ALA VAL ARG LYS VAL ALA ASP          
SEQRES  31 E  403  SER LYS LYS LEU GLU SER LYS LEU ASP TYR LYS PRO VAL          
SEQRES   1 F  439  MET ASN LEU LEU PRO ASN ILE GLU SER PRO VAL THR ARG          
SEQRES   2 F  439  GLN GLU LYS MET ALA THR VAL TRP ASP GLU ALA GLU GLN          
SEQRES   3 F  439  ASP GLY ILE GLY GLU GLU VAL LEU LYS MET SER THR GLU          
SEQRES   4 F  439  GLU ILE ILE GLN ARG THR ARG LEU LEU ASP SER GLU ILE          
SEQRES   5 F  439  LYS ILE MET LYS SER GLU VAL LEU ARG VAL THR HIS GLU          
SEQRES   6 F  439  LEU GLN ALA MET LYS ASP LYS ILE LYS GLU ASN SER GLU          
SEQRES   7 F  439  LYS ILE LYS VAL ASN LYS THR LEU PRO TYR LEU VAL SER          
SEQRES   8 F  439  ASN VAL ILE GLU LEU LEU ASP VAL ASP PRO ASN ASP GLN          
SEQRES   9 F  439  GLU GLU ASP GLY ALA ASN ILE ASP LEU ASP SER GLN ARG          
SEQRES  10 F  439  LYS GLY LYS CYS ALA VAL ILE LYS THR SER THR ARG GLN          
SEQRES  11 F  439  THR TYR PHE LEU PRO VAL ILE GLY LEU VAL ASP ALA GLU          
SEQRES  12 F  439  LYS LEU LYS PRO GLY ASP LEU VAL GLY VAL ASN LYS ASP          
SEQRES  13 F  439  SER TYR LEU ILE LEU GLU THR LEU PRO THR GLU TYR ASP          
SEQRES  14 F  439  SER ARG VAL LYS ALA MET GLU VAL ASP GLU ARG PRO THR          
SEQRES  15 F  439  GLU GLN TYR SER ASP ILE GLY GLY LEU ASP LYS GLN ILE          
SEQRES  16 F  439  GLN GLU LEU VAL GLU ALA ILE VAL LEU PRO MET ASN HIS          
SEQRES  17 F  439  LYS GLU LYS PHE GLU ASN LEU GLY ILE GLN PRO PRO LYS          
SEQRES  18 F  439  GLY VAL LEU MET TYR GLY PRO PRO GLY THR GLY LYS THR          
SEQRES  19 F  439  LEU LEU ALA ARG ALA CYS ALA ALA GLN THR LYS ALA THR          
SEQRES  20 F  439  PHE LEU LYS LEU ALA GLY PRO GLN LEU VAL GLN MET PHE          
SEQRES  21 F  439  ILE GLY ASP GLY ALA LYS LEU VAL ARG ASP ALA PHE ALA          
SEQRES  22 F  439  LEU ALA LYS GLU LYS ALA PRO SER ILE ILE PHE ILE ASP          
SEQRES  23 F  439  GLU LEU ASP ALA ILE GLY THR LYS ARG PHE ASP SER GLU          
SEQRES  24 F  439  LYS ALA GLY ASP ARG GLU VAL GLN ARG THR MET LEU GLU          
SEQRES  25 F  439  LEU LEU ASN GLN LEU ASP GLY PHE GLN PRO ASN THR GLN          
SEQRES  26 F  439  VAL LYS VAL ILE ALA ALA THR ASN ARG VAL ASP ILE LEU          
SEQRES  27 F  439  ASP PRO ALA LEU LEU ARG SER GLY ARG LEU ASP ARG LYS          
SEQRES  28 F  439  ILE GLU PHE PRO MET PRO ASN GLU GLU ALA ARG ALA ARG          
SEQRES  29 F  439  ILE MET GLN ILE HIS SER ARG LYS MET ASN VAL SER PRO          
SEQRES  30 F  439  ASP VAL ASN TYR GLU GLU LEU ALA ARG CYS THR ASP ASP          
SEQRES  31 F  439  PHE ASN GLY ALA GLN CYS LYS ALA VAL CYS VAL GLU ALA          
SEQRES  32 F  439  GLY MET ILE ALA LEU ARG ARG GLY ALA THR GLU LEU THR          
SEQRES  33 F  439  HIS GLU ASP TYR MET GLU GLY ILE LEU GLU VAL GLN ALA          
SEQRES  34 F  439  LYS LYS LYS ALA ASN LEU GLN TYR TYR ALA                      
SEQRES   1 G  245  SER ARG GLY SER SER ALA GLY PHE ASP ARG HIS ILE THR          
SEQRES   2 G  245  ILE PHE SER PRO GLU GLY ARG LEU TYR GLN VAL GLU TYR          
SEQRES   3 G  245  ALA PHE LYS ALA ILE ASN GLN GLY GLY LEU THR SER VAL          
SEQRES   4 G  245  ALA VAL ARG GLY LYS ASP CYS ALA VAL ILE VAL THR GLN          
SEQRES   5 G  245  LYS LYS VAL PRO ASP LYS LEU LEU ASP SER SER THR VAL          
SEQRES   6 G  245  THR HIS LEU PHE LYS ILE THR GLU ASN ILE GLY CYS VAL          
SEQRES   7 G  245  MET THR GLY MET THR ALA ASP SER ARG SER GLN VAL GLN          
SEQRES   8 G  245  ARG ALA ARG TYR GLU ALA ALA ASN TRP LYS TYR LYS TYR          
SEQRES   9 G  245  GLY TYR GLU ILE PRO VAL ASP MET LEU CYS LYS ARG ILE          
SEQRES  10 G  245  ALA ASP ILE SER GLN VAL TYR THR GLN ASN ALA GLU MET          
SEQRES  11 G  245  ARG PRO LEU GLY CYS CYS MET ILE LEU ILE GLY ILE ASP          
SEQRES  12 G  245  GLU GLU GLN GLY PRO GLN VAL TYR LYS CYS ASP PRO ALA          
SEQRES  13 G  245  GLY TYR TYR CYS GLY PHE LYS ALA THR ALA ALA GLY VAL          
SEQRES  14 G  245  LYS GLN THR GLU SER THR SER PHE LEU GLU LYS LYS VAL          
SEQRES  15 G  245  LYS LYS LYS PHE ASP TRP THR PHE GLU GLN THR VAL GLU          
SEQRES  16 G  245  THR ALA ILE THR CYS LEU SER THR VAL LEU SER ILE ASP          
SEQRES  17 G  245  PHE LYS PRO SER GLU ILE GLU VAL GLY VAL VAL THR VAL          
SEQRES  18 G  245  GLU ASN PRO LYS PHE ARG ILE LEU THR GLU ALA GLU ILE          
SEQRES  19 G  245  ASP ALA HIS LEU VAL ALA LEU ALA GLU ARG ASP                  
SEQRES   1 H  233  ALA GLU ARG GLY TYR SER PHE SER LEU THR THR PHE SER          
SEQRES   2 H  233  PRO SER GLY LYS LEU VAL GLN ILE GLU TYR ALA LEU ALA          
SEQRES   3 H  233  ALA VAL ALA GLY GLY ALA PRO SER VAL GLY ILE LYS ALA          
SEQRES   4 H  233  ALA ASN GLY VAL VAL LEU ALA THR GLU LYS LYS GLN LYS          
SEQRES   5 H  233  SER ILE LEU TYR ASP GLU ARG SER VAL HIS LYS VAL GLU          
SEQRES   6 H  233  PRO ILE THR LYS HIS ILE GLY LEU VAL TYR SER GLY MET          
SEQRES   7 H  233  GLY PRO ASP TYR ARG VAL LEU VAL HIS ARG ALA ARG LYS          
SEQRES   8 H  233  LEU ALA GLN GLN TYR TYR LEU VAL TYR GLN GLU PRO ILE          
SEQRES   9 H  233  PRO THR ALA GLN LEU VAL GLN ARG VAL ALA SER VAL MET          
SEQRES  10 H  233  GLN GLU TYR THR GLN SER GLY GLY VAL ARG PRO PHE GLY          
SEQRES  11 H  233  VAL SER LEU LEU ILE CYS GLY TRP ASN GLU GLY ARG PRO          
SEQRES  12 H  233  TYR LEU PHE GLN SER ASP PRO SER GLY ALA TYR PHE ALA          
SEQRES  13 H  233  TRP LYS ALA THR ALA MET GLY LYS ASN TYR VAL ASN GLY          
SEQRES  14 H  233  LYS THR PHE LEU GLU LYS ARG TYR ASN GLU ASP LEU GLU          
SEQRES  15 H  233  LEU GLU ASP ALA ILE HIS THR ALA ILE LEU THR LEU LYS          
SEQRES  16 H  233  GLU SER PHE GLU GLY GLN MET THR GLU ASP ASN ILE GLU          
SEQRES  17 H  233  VAL GLY ILE CYS ASN GLU ALA GLY PHE ARG ARG LEU THR          
SEQRES  18 H  233  PRO THR GLU VAL LYS ASP TYR LEU ALA ALA ILE ALA              
SEQRES   1 I  260  SER ARG ARG TYR ASP SER ARG THR THR ILE PHE SER PRO          
SEQRES   2 I  260  GLU GLY ARG LEU TYR GLN VAL GLU TYR ALA MET GLU ALA          
SEQRES   3 I  260  ILE GLY HIS ALA GLY THR CYS LEU GLY ILE LEU ALA ASN          
SEQRES   4 I  260  ASP GLY VAL LEU LEU ALA ALA GLU ARG ARG ASN ILE HIS          
SEQRES   5 I  260  LYS LEU LEU ASP GLU VAL PHE PHE SER GLU LYS ILE TYR          
SEQRES   6 I  260  LYS LEU ASN GLU ASP MET ALA CYS SER VAL ALA GLY ILE          
SEQRES   7 I  260  THR SER ASP ALA ASN VAL LEU THR ASN GLU LEU ARG LEU          
SEQRES   8 I  260  ILE ALA GLN ARG TYR LEU LEU GLN TYR GLN GLU PRO ILE          
SEQRES   9 I  260  PRO CYS GLU GLN LEU VAL THR ALA LEU CYS ASP ILE LYS          
SEQRES  10 I  260  GLN ALA TYR THR GLN PHE GLY GLY LYS ARG PRO PHE GLY          
SEQRES  11 I  260  VAL SER LEU LEU TYR ILE GLY TRP ASP LYS HIS TYR GLY          
SEQRES  12 I  260  PHE GLN LEU TYR GLN SER ASP PRO SER GLY ASN TYR GLY          
SEQRES  13 I  260  GLY TRP LYS ALA THR CYS ILE GLY ASN ASN SER ALA ALA          
SEQRES  14 I  260  ALA VAL SER MET LEU LYS GLN ASP TYR LYS GLU GLY GLU          
SEQRES  15 I  260  MET THR LEU LYS SER ALA LEU ALA LEU ALA ILE LYS VAL          
SEQRES  16 I  260  LEU ASN LYS THR MET ASP VAL SER LYS LEU SER ALA GLU          
SEQRES  17 I  260  LYS VAL GLU ILE ALA THR LEU THR ARG GLU ASN GLY LYS          
SEQRES  18 I  260  THR VAL ILE ARG VAL LEU LYS GLN LYS GLU VAL GLU GLN          
SEQRES  19 I  260  LEU ILE LYS LYS HIS GLU GLU GLU GLU ALA LYS ALA GLU          
SEQRES  20 I  260  ARG GLU LYS LYS GLU LYS GLU GLN LYS GLU LYS ASP LYS          
SEQRES   1 J  247  SER TYR ASP ARG ALA ILE THR VAL PHE SER PRO ASP GLY          
SEQRES   2 J  247  HIS LEU PHE GLN VAL GLU TYR ALA GLN GLU ALA VAL LYS          
SEQRES   3 J  247  LYS GLY SER THR ALA VAL GLY VAL ARG GLY ARG ASP ILE          
SEQRES   4 J  247  VAL VAL LEU GLY VAL GLU LYS LYS SER VAL ALA LYS LEU          
SEQRES   5 J  247  GLN ASP GLU ARG THR VAL ARG LYS ILE CYS ALA LEU ASP          
SEQRES   6 J  247  ASP ASN VAL CYS MET ALA PHE ALA GLY LEU THR ALA ASP          
SEQRES   7 J  247  ALA ARG ILE VAL ILE ASN ARG ALA ARG VAL GLU CYS GLN          
SEQRES   8 J  247  SER HIS ARG LEU THR VAL GLU ASP PRO VAL THR VAL GLU          
SEQRES   9 J  247  TYR ILE THR ARG TYR ILE ALA SER LEU LYS GLN ARG TYR          
SEQRES  10 J  247  THR GLN SER ASN GLY ARG ARG PRO PHE GLY ILE SER ALA          
SEQRES  11 J  247  LEU ILE VAL GLY PHE ASP PHE ASP GLY THR PRO ARG LEU          
SEQRES  12 J  247  TYR GLN THR ASP PRO SER GLY THR TYR HIS ALA TRP LYS          
SEQRES  13 J  247  ALA ASN ALA ILE GLY ARG GLY ALA LYS SER VAL ARG GLU          
SEQRES  14 J  247  PHE LEU GLU LYS ASN TYR THR ASP GLU ALA ILE GLU THR          
SEQRES  15 J  247  ASP ASP LEU THR ILE LYS LEU VAL ILE LYS ALA LEU LEU          
SEQRES  16 J  247  GLU VAL VAL GLN SER GLY GLY LYS ASN ILE GLU LEU ALA          
SEQRES  17 J  247  VAL MET ARG ARG ASP GLN SER LEU LYS ILE LEU ASN PRO          
SEQRES  18 J  247  GLU GLU ILE GLU LYS TYR VAL ALA GLU ILE GLU LYS GLU          
SEQRES  19 J  247  LYS GLU GLU ASN GLU LYS LYS LYS GLN LYS LYS ALA SER          
SEQRES   1 K  240  PHE LEU THR ARG SER GLU TYR ASP ARG GLY VAL ASN THR          
SEQRES   2 K  240  PHE SER PRO GLU GLY ARG LEU PHE GLN VAL GLU TYR ALA          
SEQRES   3 K  240  ILE GLU ALA ILE LYS LEU GLY SER THR ALA ILE GLY ILE          
SEQRES   4 K  240  GLN THR SER GLU GLY VAL CYS LEU ALA VAL GLU LYS ARG          
SEQRES   5 K  240  ILE THR SER PRO LEU MET GLU PRO SER SER ILE GLU LYS          
SEQRES   6 K  240  ILE VAL GLU ILE ASP ALA HIS ILE GLY CYS ALA MET SER          
SEQRES   7 K  240  GLY LEU ILE ALA ASP ALA LYS THR LEU ILE ASP LYS ALA          
SEQRES   8 K  240  ARG VAL GLU THR GLN ASN HIS TRP PHE THR TYR ASN GLU          
SEQRES   9 K  240  THR MET THR VAL GLU SER VAL THR GLN ALA VAL SER ASN          
SEQRES  10 K  240  LEU ALA LEU GLN PHE GLY GLU GLU ASP ALA ASP PRO GLY          
SEQRES  11 K  240  ALA MET SER ARG PRO PHE GLY VAL ALA LEU LEU PHE GLY          
SEQRES  12 K  240  GLY VAL ASP GLU LYS GLY PRO GLN LEU PHE HIS MET ASP          
SEQRES  13 K  240  PRO SER GLY THR PHE VAL GLN CYS ASP ALA ARG ALA ILE          
SEQRES  14 K  240  GLY SER ALA SER GLU GLY ALA GLN SER SER LEU GLN GLU          
SEQRES  15 K  240  VAL TYR HIS LYS SER MET THR LEU LYS GLU ALA ILE LYS          
SEQRES  16 K  240  SER SER LEU ILE ILE LEU LYS GLN VAL MET GLU GLU LYS          
SEQRES  17 K  240  LEU ASN ALA THR ASN ILE GLU LEU ALA THR VAL GLN PRO          
SEQRES  18 K  240  GLY GLN ASN PHE HIS MET PHE THR LYS GLU GLU LEU GLU          
SEQRES  19 K  240  GLU VAL ILE LYS ASP ILE                                      
SEQRES   1 L  268  GLN LEU SER LYS VAL LYS PHE ARG ASN GLN TYR ASP ASN          
SEQRES   2 L  268  ASP VAL THR VAL TRP SER PRO GLN GLY ARG ILE HIS GLN          
SEQRES   3 L  268  ILE GLU TYR ALA MET GLU ALA VAL LYS GLN GLY SER ALA          
SEQRES   4 L  268  THR VAL GLY LEU LYS SER LYS THR HIS ALA VAL LEU VAL          
SEQRES   5 L  268  ALA LEU LYS ARG ALA GLN SER GLU LEU ALA ALA HIS GLN          
SEQRES   6 L  268  LYS LYS ILE LEU HIS VAL ASP ASN HIS ILE GLY ILE SER          
SEQRES   7 L  268  ILE ALA GLY LEU THR ALA ASP ALA ARG LEU LEU CYS ASN          
SEQRES   8 L  268  PHE MET ARG GLN GLU CYS LEU ASP SER ARG PHE VAL PHE          
SEQRES   9 L  268  ASP ARG PRO LEU PRO VAL SER ARG LEU VAL SER LEU ILE          
SEQRES  10 L  268  GLY SER LYS THR GLN ILE PRO THR GLN ARG TYR GLY ARG          
SEQRES  11 L  268  ARG PRO TYR GLY VAL GLY LEU LEU ILE ALA GLY TYR ASP          
SEQRES  12 L  268  ASP MET GLY PRO HIS ILE PHE GLN THR CYS PRO SER ALA          
SEQRES  13 L  268  ASN TYR PHE ASP CYS ARG ALA MET SER ILE GLY ALA ARG          
SEQRES  14 L  268  SER GLN SER ALA ARG THR TYR LEU GLU ARG HIS MET SER          
SEQRES  15 L  268  GLU PHE MET GLU CYS ASN LEU ASN GLU LEU VAL LYS HIS          
SEQRES  16 L  268  GLY LEU ARG ALA LEU ARG GLU THR LEU PRO ALA GLU GLN          
SEQRES  17 L  268  ASP LEU THR THR LYS ASN VAL SER ILE GLY ILE VAL GLY          
SEQRES  18 L  268  LYS ASP LEU GLU PHE THR ILE TYR ASP ASP ASP ASP VAL          
SEQRES  19 L  268  SER PRO PHE LEU GLU GLY LEU GLU GLU ARG PRO GLN ARG          
SEQRES  20 L  268  LYS ALA GLN PRO ALA GLN PRO ALA ASP GLU PRO ALA GLU          
SEQRES  21 L  268  LYS ALA ASP GLU PRO MET GLU HIS                              
SEQRES   1 M  254  SER SER ILE GLY THR GLY TYR ASP LEU SER ALA SER THR          
SEQRES   2 M  254  PHE SER PRO ASP GLY ARG VAL PHE GLN VAL GLU TYR ALA          
SEQRES   3 M  254  MET LYS ALA VAL GLU ASN SER SER THR ALA ILE GLY ILE          
SEQRES   4 M  254  ARG CYS LYS ASP GLY VAL VAL PHE GLY VAL GLU LYS LEU          
SEQRES   5 M  254  VAL LEU SER LYS LEU TYR GLU GLU GLY SER ASN LYS ARG          
SEQRES   6 M  254  LEU PHE ASN VAL ASP ARG HIS VAL GLY MET ALA VAL ALA          
SEQRES   7 M  254  GLY LEU LEU ALA ASP ALA ARG SER LEU ALA ASP ILE ALA          
SEQRES   8 M  254  ARG GLU GLU ALA SER ASN PHE ARG SER ASN PHE GLY TYR          
SEQRES   9 M  254  ASN ILE PRO LEU LYS HIS LEU ALA ASP ARG VAL ALA MET          
SEQRES  10 M  254  TYR VAL HIS ALA TYR THR LEU TYR SER ALA VAL ARG PRO          
SEQRES  11 M  254  PHE GLY CYS SER PHE MET LEU GLY SER TYR SER VAL ASN          
SEQRES  12 M  254  ASP GLY ALA GLN LEU TYR MET ILE ASP PRO SER GLY VAL          
SEQRES  13 M  254  SER TYR GLY TYR TRP GLY CYS ALA ILE GLY LYS ALA ARG          
SEQRES  14 M  254  GLN ALA ALA LYS THR GLU ILE GLU LYS LEU GLN MET LYS          
SEQRES  15 M  254  GLU MET THR CYS ARG ASP ILE VAL LYS GLU VAL ALA LYS          
SEQRES  16 M  254  ILE ILE TYR ILE VAL HIS ASP GLU VAL LYS ASP LYS ALA          
SEQRES  17 M  254  PHE GLU LEU GLU LEU SER TRP VAL GLY GLU LEU THR ASN          
SEQRES  18 M  254  GLY ARG HIS GLU ILE VAL PRO LYS ASP ILE ARG GLU GLU          
SEQRES  19 M  254  ALA GLU LYS TYR ALA LYS GLU SER LEU LYS GLU GLU ASP          
SEQRES  20 M  254  GLU SER ASP ASP ASP ASN MET                                  
SEQRES   1 N  238  ALA ALA THR LEU LEU ALA ALA ARG GLY ALA GLY PRO ALA          
SEQRES   2 N  238  PRO ALA TRP GLY PRO GLU ALA PHE THR PRO ASP TRP GLU          
SEQRES   3 N  238  SER ARG GLU VAL SER THR GLY THR THR ILE MET ALA VAL          
SEQRES   4 N  238  GLN PHE ASP GLY GLY VAL VAL LEU GLY ALA ASP SER ARG          
SEQRES   5 N  238  THR THR THR GLY SER TYR ILE ALA ASN ARG VAL THR ASP          
SEQRES   6 N  238  LYS LEU THR PRO ILE HIS ASP ARG ILE PHE CYS CYS ARG          
SEQRES   7 N  238  SER GLY SER ALA ALA ASP THR GLN ALA VAL ALA ASP ALA          
SEQRES   8 N  238  VAL THR TYR GLN LEU GLY PHE HIS SER ILE GLU LEU ASN          
SEQRES   9 N  238  GLU PRO PRO LEU VAL HIS THR ALA ALA SER LEU PHE LYS          
SEQRES  10 N  238  GLU MET CYS TYR ARG TYR ARG GLU ASP LEU MET ALA GLY          
SEQRES  11 N  238  ILE ILE ILE ALA GLY TRP ASP PRO GLN GLU GLY GLY GLN          
SEQRES  12 N  238  VAL TYR SER VAL PRO MET GLY GLY MET MET VAL ARG GLN          
SEQRES  13 N  238  SER PHE ALA ILE GLY GLY SER GLY SER SER TYR ILE TYR          
SEQRES  14 N  238  GLY TYR VAL ASP ALA THR TYR ARG GLU GLY MET THR LYS          
SEQRES  15 N  238  GLU GLU CYS LEU GLN PHE THR ALA ASN ALA LEU ALA LEU          
SEQRES  16 N  238  ALA MET GLU ARG ASP GLY SER SER GLY GLY VAL ILE ARG          
SEQRES  17 N  238  LEU ALA ALA ILE ALA GLU SER GLY VAL GLU ARG GLN VAL          
SEQRES  18 N  238  LEU LEU GLY ASP GLN ILE PRO LYS PHE ALA VAL ALA THR          
SEQRES  19 N  238  LEU PRO PRO ALA                                              
SEQRES   1 O  276  ALA ALA VAL SER VAL TYR ALA PRO PRO VAL GLY GLY PHE          
SEQRES   2 O  276  SER PHE ASP ASN CYS ARG ARG ASN ALA VAL LEU GLU ALA          
SEQRES   3 O  276  ASP PHE ALA LYS ARG GLY TYR LYS LEU PRO LYS VAL ARG          
SEQRES   4 O  276  LYS THR GLY THR THR ILE ALA GLY VAL VAL TYR LYS ASP          
SEQRES   5 O  276  GLY ILE VAL LEU GLY ALA ASP THR ARG ALA THR GLU GLY          
SEQRES   6 O  276  MET VAL VAL ALA ASP LYS ASN CYS SER LYS ILE HIS PHE          
SEQRES   7 O  276  ILE SER PRO ASN ILE TYR CYS CYS GLY ALA GLY THR ALA          
SEQRES   8 O  276  ALA ASP THR ASP MET THR THR GLN LEU ILE SER SER ASN          
SEQRES   9 O  276  LEU GLU LEU HIS SER LEU SER THR GLY ARG LEU PRO ARG          
SEQRES  10 O  276  VAL VAL THR ALA ASN ARG MET LEU LYS GLN MET LEU PHE          
SEQRES  11 O  276  ARG TYR GLN GLY TYR ILE GLY ALA ALA LEU VAL LEU GLY          
SEQRES  12 O  276  GLY VAL ASP VAL THR GLY PRO HIS LEU TYR SER ILE TYR          
SEQRES  13 O  276  PRO HIS GLY SER THR ASP LYS LEU PRO TYR VAL THR MET          
SEQRES  14 O  276  GLY SER GLY SER LEU ALA ALA MET ALA VAL PHE GLU ASP          
SEQRES  15 O  276  LYS PHE ARG PRO ASP MET GLU GLU GLU GLU ALA LYS ASN          
SEQRES  16 O  276  LEU VAL SER GLU ALA ILE ALA ALA GLY ILE PHE ASN ASP          
SEQRES  17 O  276  LEU GLY SER GLY SER ASN ILE ASP LEU CYS VAL ILE SER          
SEQRES  18 O  276  LYS ASN LYS LEU ASP PHE LEU ARG PRO TYR THR VAL PRO          
SEQRES  19 O  276  ASN LYS LYS GLY THR ARG LEU GLY ARG TYR ARG CYS GLU          
SEQRES  20 O  276  LYS GLY THR THR ALA VAL LEU THR GLU LYS ILE THR PRO          
SEQRES  21 O  276  LEU GLU ILE GLU VAL LEU GLU GLU THR VAL GLN THR MET          
SEQRES  22 O  276  ASP THR SER                                                  
SEQRES   1 P  204  SER ILE MET SER TYR ASN GLY GLY ALA VAL MET ALA MET          
SEQRES   2 P  204  LYS GLY LYS ASN CYS VAL ALA ILE ALA ALA ASP ARG ARG          
SEQRES   3 P  204  PHE GLY ILE GLN ALA GLN MET VAL THR THR ASP PHE GLN          
SEQRES   4 P  204  LYS ILE PHE PRO MET GLY ASP ARG LEU TYR ILE GLY LEU          
SEQRES   5 P  204  ALA GLY LEU ALA THR ASP VAL GLN THR VAL ALA GLN ARG          
SEQRES   6 P  204  LEU LYS PHE ARG LEU ASN LEU TYR GLU LEU LYS GLU GLY          
SEQRES   7 P  204  ARG GLN ILE LYS PRO TYR THR LEU MET SER MET VAL ALA          
SEQRES   8 P  204  ASN LEU LEU TYR GLU LYS ARG PHE GLY PRO TYR TYR THR          
SEQRES   9 P  204  GLU PRO VAL ILE ALA GLY LEU ASP PRO LYS THR PHE LYS          
SEQRES  10 P  204  PRO PHE ILE CYS SER LEU ASP LEU ILE GLY CYS PRO MET          
SEQRES  11 P  204  VAL THR ASP ASP PHE VAL VAL SER GLY THR CYS ALA GLU          
SEQRES  12 P  204  GLN MET TYR GLY MET CYS GLU SER LEU TRP GLU PRO ASN          
SEQRES  13 P  204  MET ASP PRO ASP HIS LEU PHE GLU THR ILE SER GLN ALA          
SEQRES  14 P  204  MET LEU ASN ALA VAL ASP ARG ASP ALA VAL SER GLY MET          
SEQRES  15 P  204  GLY VAL ILE VAL HIS ILE ILE GLU LYS ASP LYS ILE THR          
SEQRES  16 P  204  THR ARG THR LEU LYS ALA ARG MET ASP                          
SEQRES   1 Q  201  MET GLU TYR LEU ILE GLY ILE GLN GLY PRO ASP TYR VAL          
SEQRES   2 Q  201  LEU VAL ALA SER ASP ARG VAL ALA ALA SER ASN ILE VAL          
SEQRES   3 Q  201  GLN MET LYS ASP ASP HIS ASP LYS MET PHE LYS MET SER          
SEQRES   4 Q  201  GLU LYS ILE LEU LEU LEU CYS VAL GLY GLU ALA GLY ASP          
SEQRES   5 Q  201  THR VAL GLN PHE ALA GLU TYR ILE GLN LYS ASN VAL GLN          
SEQRES   6 Q  201  LEU TYR LYS MET ARG ASN GLY TYR GLU LEU SER PRO THR          
SEQRES   7 Q  201  ALA ALA ALA ASN PHE THR ARG ARG ASN LEU ALA ASP CYS          
SEQRES   8 Q  201  LEU ARG SER ARG THR PRO TYR HIS VAL ASN LEU LEU LEU          
SEQRES   9 Q  201  ALA GLY TYR ASP GLU HIS GLU GLY PRO ALA LEU TYR TYR          
SEQRES  10 Q  201  MET ASP TYR LEU ALA ALA LEU ALA LYS ALA PRO PHE ALA          
SEQRES  11 Q  201  ALA HIS GLY TYR GLY ALA PHE LEU THR LEU SER ILE LEU          
SEQRES  12 Q  201  ASP ARG TYR TYR THR PRO THR ILE SER ARG GLU ARG ALA          
SEQRES  13 Q  201  VAL GLU LEU LEU ARG LYS CYS LEU GLU GLU LEU GLN LYS          
SEQRES  14 Q  201  ARG PHE ILE LEU ASN LEU PRO THR PHE SER VAL ARG ILE          
SEQRES  15 Q  201  ILE ASP LYS ASN GLY ILE HIS ASP LEU ASP ASN ILE SER          
SEQRES  16 Q  201  PHE PRO LYS GLN GLY SER                                      
SEQRES   1 R  262  ALA LEU ALA SER VAL LEU GLU ARG PRO LEU PRO VAL ASN          
SEQRES   2 R  262  GLN ARG GLY PHE PHE GLY LEU GLY GLY ARG ALA ASP LEU          
SEQRES   3 R  262  LEU ASP LEU GLY PRO GLY SER LEU SER ASP GLY LEU SER          
SEQRES   4 R  262  LEU ALA ALA PRO GLY TRP GLY VAL PRO GLU GLU PRO GLY          
SEQRES   5 R  262  ILE GLU MET LEU HIS GLY THR THR THR LEU ALA PHE LYS          
SEQRES   6 R  262  PHE ARG HIS GLY VAL ILE VAL ALA ALA ASP SER ARG ALA          
SEQRES   7 R  262  THR ALA GLY ALA TYR ILE ALA SER GLN THR VAL LYS LYS          
SEQRES   8 R  262  VAL ILE GLU ILE ASN PRO TYR LEU LEU GLY THR MET ALA          
SEQRES   9 R  262  GLY GLY ALA ALA ASP CYS SER PHE TRP GLU ARG LEU LEU          
SEQRES  10 R  262  ALA ARG GLN CYS ARG ILE TYR GLU LEU ARG ASN LYS GLU          
SEQRES  11 R  262  ARG ILE SER VAL ALA ALA ALA SER LYS LEU LEU ALA ASN          
SEQRES  12 R  262  MET VAL TYR GLN TYR LYS GLY MET GLY LEU SER MET GLY          
SEQRES  13 R  262  THR MET ILE CYS GLY TRP ASP LYS ARG GLY PRO GLY LEU          
SEQRES  14 R  262  TYR TYR VAL ASP SER GLU GLY ASN ARG ILE SER GLY ALA          
SEQRES  15 R  262  THR PHE SER VAL GLY SER GLY SER VAL TYR ALA TYR GLY          
SEQRES  16 R  262  VAL MET ASP ARG GLY TYR SER TYR ASP LEU GLU VAL GLU          
SEQRES  17 R  262  GLN ALA TYR ASP LEU ALA ARG ARG ALA ILE TYR GLN ALA          
SEQRES  18 R  262  THR TYR ARG ASP ALA TYR SER GLY GLY ALA VAL ASN LEU          
SEQRES  19 R  262  TYR HIS VAL ARG GLU ASP GLY TRP ILE ARG VAL SER SER          
SEQRES  20 R  262  ASP ASN VAL ALA ASP LEU HIS GLU LYS TYR SER GLY SER          
SEQRES  21 R  262  THR PRO                                                      
SEQRES   1 S  240  LEU SER SER THR ALA MET TYR SER ALA PRO GLY ARG ASP          
SEQRES   2 S  240  LEU GLY MET GLU PRO HIS ARG ALA ALA GLY PRO LEU GLN          
SEQRES   3 S  240  LEU ARG PHE SER PRO TYR VAL PHE ASN GLY GLY THR ILE          
SEQRES   4 S  240  LEU ALA ILE ALA GLY GLU ASP PHE ALA ILE VAL ALA SER          
SEQRES   5 S  240  ASP THR ARG LEU SER GLU GLY PHE SER ILE HIS THR ARG          
SEQRES   6 S  240  ASP SER PRO LYS CYS TYR LYS LEU THR ASP LYS THR VAL          
SEQRES   7 S  240  ILE GLY CYS SER GLY PHE HIS GLY ASP CYS LEU THR LEU          
SEQRES   8 S  240  THR LYS ILE ILE GLU ALA ARG LEU LYS MET TYR LYS HIS          
SEQRES   9 S  240  SER ASN ASN LYS ALA MET THR THR GLY ALA ILE ALA ALA          
SEQRES  10 S  240  MET LEU SER THR ILE LEU TYR SER ARG ARG PHE PHE PRO          
SEQRES  11 S  240  TYR TYR VAL TYR ASN ILE ILE GLY GLY LEU ASP GLU GLU          
SEQRES  12 S  240  GLY LYS GLY ALA VAL TYR SER PHE ASP PRO VAL GLY SER          
SEQRES  13 S  240  TYR GLN ARG ASP SER PHE LYS ALA GLY GLY SER ALA SER          
SEQRES  14 S  240  ALA MET LEU GLN PRO LEU LEU ASP ASN GLN VAL GLY PHE          
SEQRES  15 S  240  LYS ASN MET GLN ASN VAL GLU HIS VAL PRO LEU SER LEU          
SEQRES  16 S  240  ASP ARG ALA MET ARG LEU VAL LYS ASP VAL PHE ILE SER          
SEQRES  17 S  240  ALA ALA GLU ARG ASP VAL TYR THR GLY ASP ALA LEU ARG          
SEQRES  18 S  240  ILE CYS ILE VAL THR LYS GLU GLY ILE ARG GLU GLU THR          
SEQRES  19 S  240  VAL SER LEU ARG LYS ASP                                      
SEQRES   1 T  263  GLU ALA PHE LEU GLY SER ARG SER GLY LEU TRP ALA GLY          
SEQRES   2 T  263  GLY PRO ALA PRO GLY GLN PHE TYR ARG ILE PRO SER THR          
SEQRES   3 T  263  PRO ASP SER PHE MET ASP PRO ALA SER ALA LEU TYR ARG          
SEQRES   4 T  263  GLY PRO ILE THR ARG THR GLN ASN PRO MET VAL THR GLY          
SEQRES   5 T  263  THR SER VAL LEU GLY VAL LYS PHE GLU GLY GLY VAL VAL          
SEQRES   6 T  263  ILE ALA ALA ASP MET LEU GLY SER TYR GLY SER LEU ALA          
SEQRES   7 T  263  ARG PHE ARG ASN ILE SER ARG ILE MET ARG VAL ASN ASN          
SEQRES   8 T  263  SER THR MET LEU GLY ALA SER GLY ASP TYR ALA ASP PHE          
SEQRES   9 T  263  GLN TYR LEU LYS GLN VAL LEU GLY GLN MET VAL ILE ASP          
SEQRES  10 T  263  GLU GLU LEU LEU GLY ASP GLY HIS SER TYR SER PRO ARG          
SEQRES  11 T  263  ALA ILE HIS SER TRP LEU THR ARG ALA MET TYR SER ARG          
SEQRES  12 T  263  ARG SER LYS MET ASN PRO LEU TRP ASN THR MET VAL ILE          
SEQRES  13 T  263  GLY GLY TYR ALA ASP GLY GLU SER PHE LEU GLY TYR VAL          
SEQRES  14 T  263  ASP MET LEU GLY VAL ALA TYR GLU ALA PRO SER LEU ALA          
SEQRES  15 T  263  THR GLY TYR GLY ALA TYR LEU ALA GLN PRO LEU LEU ARG          
SEQRES  16 T  263  GLU VAL LEU GLU LYS GLN PRO VAL LEU SER GLN THR GLU          
SEQRES  17 T  263  ALA ARG ASP LEU VAL GLU ARG CYS MET ARG VAL LEU TYR          
SEQRES  18 T  263  TYR ARG ASP ALA ARG SER TYR ASN ARG PHE GLN ILE ALA          
SEQRES  19 T  263  THR VAL THR GLU LYS GLY VAL GLU ILE GLU GLY PRO LEU          
SEQRES  20 T  263  SER THR GLU THR ASN TRP ASP ILE ALA HIS MET ILE SER          
SEQRES  21 T  263  GLY PHE GLU                                                  
SEQRES   1 U  953  MET ILE THR SER ALA ALA GLY ILE ILE SER LEU LEU ASP          
SEQRES   2 U  953  GLU ASP GLU PRO GLN LEU LYS GLU PHE ALA LEU HIS LYS          
SEQRES   3 U  953  LEU ASN ALA VAL VAL ASN ASP PHE TRP ALA GLU ILE SER          
SEQRES   4 U  953  GLU SER VAL ASP LYS ILE GLU VAL LEU TYR GLU ASP GLU          
SEQRES   5 U  953  GLY PHE ARG SER ARG GLN PHE ALA ALA LEU VAL ALA SER          
SEQRES   6 U  953  LYS VAL PHE TYR HIS LEU GLY ALA PHE GLU GLU SER LEU          
SEQRES   7 U  953  ASN TYR ALA LEU GLY ALA GLY ASP LEU PHE ASN VAL ASN          
SEQRES   8 U  953  ASP ASN SER GLU TYR VAL GLU THR ILE ILE ALA LYS CYS          
SEQRES   9 U  953  ILE ASP HIS TYR THR LYS GLN CYS VAL GLU ASN ALA ASP          
SEQRES  10 U  953  LEU PRO GLU GLY GLU LYS LYS PRO ILE ASP GLN ARG LEU          
SEQRES  11 U  953  GLU GLY ILE VAL ASN LYS MET PHE GLN ARG CYS LEU ASP          
SEQRES  12 U  953  ASP HIS LYS TYR LYS GLN ALA ILE GLY ILE ALA LEU GLU          
SEQRES  13 U  953  THR ARG ARG LEU ASP VAL PHE GLU LYS THR ILE LEU GLU          
SEQRES  14 U  953  SER ASN ASP VAL PRO GLY MET LEU ALA TYR SER LEU LYS          
SEQRES  15 U  953  LEU CYS MET SER LEU MET GLN ASN LYS GLN PHE ARG ASN          
SEQRES  16 U  953  LYS VAL LEU ARG VAL LEU VAL LYS ILE TYR MET ASN LEU          
SEQRES  17 U  953  GLU LYS PRO ASP PHE ILE ASN VAL CYS GLN CYS LEU ILE          
SEQRES  18 U  953  PHE LEU ASP ASP PRO GLN ALA VAL SER ASP ILE LEU GLU          
SEQRES  19 U  953  LYS LEU VAL LYS GLU ASP ASN LEU LEU MET ALA TYR GLN          
SEQRES  20 U  953  ILE CYS PHE ASP LEU TYR GLU SER ALA SER GLN GLN PHE          
SEQRES  21 U  953  LEU SER SER VAL ILE GLN ASN LEU ARG THR VAL GLY THR          
SEQRES  22 U  953  PRO ILE ALA SER VAL PRO GLY SER THR ASN THR GLY THR          
SEQRES  23 U  953  VAL PRO GLY SER GLU LYS ASP SER ASP SER MET GLU THR          
SEQRES  24 U  953  GLU GLU LYS THR SER SER ALA PHE VAL GLY LYS THR PRO          
SEQRES  25 U  953  GLU ALA SER PRO GLU PRO LYS ASP GLN THR LEU LYS MET          
SEQRES  26 U  953  ILE LYS ILE LEU SER GLY GLU MET ALA ILE GLU LEU HIS          
SEQRES  27 U  953  LEU GLN PHE LEU ILE ARG ASN ASN ASN THR ASP LEU MET          
SEQRES  28 U  953  ILE LEU LYS ASN THR LYS ASP ALA VAL ARG ASN SER VAL          
SEQRES  29 U  953  CYS HIS THR ALA THR VAL ILE ALA ASN SER PHE MET HIS          
SEQRES  30 U  953  CYS GLY THR THR SER ASP GLN PHE LEU ARG ASP ASN LEU          
SEQRES  31 U  953  GLU TRP LEU ALA ARG ALA THR ASN TRP ALA LYS PHE THR          
SEQRES  32 U  953  ALA THR ALA SER LEU GLY VAL ILE HIS LYS GLY HIS GLU          
SEQRES  33 U  953  LYS GLU ALA LEU GLN LEU MET ALA THR TYR LEU PRO LYS          
SEQRES  34 U  953  ASP THR SER PRO GLY SER ALA TYR GLN GLU GLY GLY GLY          
SEQRES  35 U  953  LEU TYR ALA LEU GLY LEU ILE HIS ALA ASN HIS GLY GLY          
SEQRES  36 U  953  ASP ILE ILE ASP TYR LEU LEU ASN GLN LEU LYS ASN ALA          
SEQRES  37 U  953  SER ASN ASP ILE VAL ARG HIS GLY GLY SER LEU GLY LEU          
SEQRES  38 U  953  GLY LEU ALA ALA MET GLY THR ALA ARG GLN ASP VAL TYR          
SEQRES  39 U  953  ASP LEU LEU LYS THR ASN LEU TYR GLN ASP ASP ALA VAL          
SEQRES  40 U  953  THR GLY GLU ALA ALA GLY LEU ALA LEU GLY LEU VAL MET          
SEQRES  41 U  953  LEU GLY SER LYS ASN ALA GLN ALA ILE GLU ASP MET VAL          
SEQRES  42 U  953  GLY TYR ALA GLN GLU THR GLN HIS GLU LYS ILE LEU ARG          
SEQRES  43 U  953  GLY LEU ALA VAL GLY ILE ALA LEU VAL MET TYR GLY ARG          
SEQRES  44 U  953  MET GLU GLU ALA ASP ALA LEU ILE GLU SER LEU CYS ARG          
SEQRES  45 U  953  ASP LYS ASP PRO ILE LEU ARG ARG SER GLY MET TYR THR          
SEQRES  46 U  953  VAL ALA MET ALA TYR CYS GLY SER GLY ASN ASN LYS ALA          
SEQRES  47 U  953  ILE ARG ARG LEU LEU HIS VAL ALA VAL SER ASP VAL ASN          
SEQRES  48 U  953  ASP ASP VAL ARG ARG ALA ALA VAL GLU SER LEU GLY PHE          
SEQRES  49 U  953  ILE LEU PHE ARG THR PRO GLU GLN CYS PRO SER VAL VAL          
SEQRES  50 U  953  SER LEU LEU SER GLU SER TYR ASN PRO HIS VAL ARG TYR          
SEQRES  51 U  953  GLY ALA ALA MET ALA LEU GLY ILE CYS CYS ALA GLY THR          
SEQRES  52 U  953  GLY ASN LYS GLU ALA ILE ASN LEU LEU GLU PRO MET THR          
SEQRES  53 U  953  ASN ASP PRO VAL ASN TYR VAL ARG GLN GLY ALA LEU ILE          
SEQRES  54 U  953  ALA SER ALA LEU ILE MET ILE GLN GLN THR GLU ILE THR          
SEQRES  55 U  953  CYS PRO LYS VAL ASN GLN PHE ARG GLN LEU TYR SER LYS          
SEQRES  56 U  953  VAL ILE ASN ASP LYS HIS ASP ASP VAL MET ALA LYS PHE          
SEQRES  57 U  953  GLY ALA ILE LEU ALA GLN GLY ILE LEU ASP ALA GLY GLY          
SEQRES  58 U  953  HIS ASN VAL THR ILE SER LEU GLN SER ARG THR GLY HIS          
SEQRES  59 U  953  THR HIS MET PRO SER VAL VAL GLY VAL LEU VAL PHE THR          
SEQRES  60 U  953  GLN PHE TRP PHE TRP PHE PRO LEU SER HIS PHE LEU SER          
SEQRES  61 U  953  LEU ALA TYR THR PRO THR CYS VAL ILE GLY LEU ASN LYS          
SEQRES  62 U  953  ASP LEU LYS MET PRO LYS VAL GLN TYR LYS SER ASN CYS          
SEQRES  63 U  953  LYS PRO SER THR PHE ALA TYR PRO ALA PRO LEU GLU VAL          
SEQRES  64 U  953  PRO LYS GLU LYS GLU LYS GLU LYS VAL SER THR ALA VAL          
SEQRES  65 U  953  LEU SER ILE THR ALA LYS ALA LYS LYS LYS GLU LYS GLU          
SEQRES  66 U  953  LYS GLU LYS LYS GLU GLU GLU LYS MET GLU VAL ASP GLU          
SEQRES  67 U  953  ALA GLU LYS LYS GLU GLU LYS GLU LYS LYS LYS GLU PRO          
SEQRES  68 U  953  GLU PRO ASN PHE GLN LEU LEU ASP ASN PRO ALA ARG VAL          
SEQRES  69 U  953  MET PRO ALA GLN LEU LYS VAL LEU THR MET PRO GLU THR          
SEQRES  70 U  953  CYS ARG TYR GLN PRO PHE LYS PRO LEU SER ILE GLY GLY          
SEQRES  71 U  953  ILE ILE ILE LEU LYS ASP THR SER GLU ASP ILE GLU GLU          
SEQRES  72 U  953  LEU VAL GLU PRO VAL ALA ALA HIS GLY PRO LYS ILE GLU          
SEQRES  73 U  953  GLU GLU GLU GLN GLU PRO GLU PRO PRO GLU PRO PHE GLU          
SEQRES  74 U  953  TYR ILE ASP ASP                                              
SEQRES   1 V  533  LYS GLN GLU GLY SER ALA ARG ARG ARG GLY ALA ASP LYS          
SEQRES   2 V  533  ALA LYS PRO PRO PRO GLY GLY GLY GLU GLN GLU PRO PRO          
SEQRES   3 V  533  PRO PRO PRO ALA PRO GLN ASP VAL GLU MET LYS GLU GLU          
SEQRES   4 V  533  ALA ALA THR GLY GLY GLY SER THR GLY GLU ALA ASP GLY          
SEQRES   5 V  533  LYS THR ALA ALA ALA ALA ALA GLU HIS SER GLN ARG GLU          
SEQRES   6 V  533  LEU ASP THR VAL THR LEU GLU ASP ILE LYS GLU HIS VAL          
SEQRES   7 V  533  LYS GLN LEU GLU LYS ALA VAL SER GLY LYS GLU PRO ARG          
SEQRES   8 V  533  PHE VAL LEU ARG ALA LEU ARG MET LEU PRO SER THR SER          
SEQRES   9 V  533  ARG ARG LEU ASN HIS TYR VAL LEU TYR LYS ALA VAL GLN          
SEQRES  10 V  533  GLY PHE PHE THR SER ASN ASN ALA THR ARG ASP PHE LEU          
SEQRES  11 V  533  LEU PRO PHE LEU GLU GLU PRO MET ASP THR GLU ALA ASP          
SEQRES  12 V  533  LEU GLN PHE ARG PRO ARG THR GLY LYS ALA ALA SER THR          
SEQRES  13 V  533  PRO LEU LEU PRO GLU VAL GLU ALA TYR LEU GLN LEU LEU          
SEQRES  14 V  533  VAL VAL ILE PHE MET MET ASN SER LYS ARG TYR LYS GLU          
SEQRES  15 V  533  ALA GLN LYS ILE SER ASP ASP LEU MET GLN LYS ILE SER          
SEQRES  16 V  533  THR GLN ASN ARG ARG ALA LEU ASP LEU VAL ALA ALA LYS          
SEQRES  17 V  533  CYS TYR TYR TYR HIS ALA ARG VAL TYR GLU PHE LEU ASP          
SEQRES  18 V  533  LYS LEU ASP VAL VAL ARG SER PHE LEU HIS ALA ARG LEU          
SEQRES  19 V  533  ARG THR ALA THR LEU ARG HIS ASP ALA ASP GLY GLN ALA          
SEQRES  20 V  533  THR LEU LEU ASN LEU LEU LEU ARG ASN TYR LEU HIS TYR          
SEQRES  21 V  533  SER LEU TYR ASP GLN ALA GLU LYS LEU VAL SER LYS SER          
SEQRES  22 V  533  VAL PHE PRO GLU GLN ALA ASN ASN ASN GLU TRP ALA ARG          
SEQRES  23 V  533  TYR LEU TYR TYR THR GLY ARG ILE LYS ALA ILE GLN LEU          
SEQRES  24 V  533  GLU TYR SER GLU ALA ARG ARG THR MET THR ASN ALA LEU          
SEQRES  25 V  533  ARG LYS ALA PRO GLN HIS THR ALA VAL GLY PHE LYS GLN          
SEQRES  26 V  533  THR VAL HIS LYS LEU LEU ILE VAL VAL GLU LEU LEU LEU          
SEQRES  27 V  533  GLY GLU ILE PRO ASP ARG LEU GLN PHE ARG GLN PRO SER          
SEQRES  28 V  533  LEU LYS ARG SER LEU MET PRO TYR PHE LEU LEU THR GLN          
SEQRES  29 V  533  ALA VAL ARG THR GLY ASN LEU ALA LYS PHE ASN GLN VAL          
SEQRES  30 V  533  LEU ASP GLN PHE GLY GLU LYS PHE GLN ALA ASP GLY THR          
SEQRES  31 V  533  TYR THR LEU ILE ILE ARG LEU ARG HIS ASN VAL ILE LYS          
SEQRES  32 V  533  THR GLY VAL ARG MET ILE SER LEU SER TYR SER ARG ILE          
SEQRES  33 V  533  SER LEU ALA ASP ILE ALA GLN LYS LEU GLN LEU ASP SER          
SEQRES  34 V  533  PRO GLU ASP ALA GLU PHE ILE VAL ALA LYS ALA ILE ARG          
SEQRES  35 V  533  ASP GLY VAL ILE GLU ALA SER ILE ASN HIS GLU LYS GLY          
SEQRES  36 V  533  TYR VAL GLN SER LYS GLU MET ILE ASP ILE TYR SER THR          
SEQRES  37 V  533  ARG GLU PRO GLN LEU ALA PHE HIS GLN ARG ILE SER PHE          
SEQRES  38 V  533  CYS LEU ASP ILE HIS ASN MET SER VAL LYS ALA MET ARG          
SEQRES  39 V  533  PHE PRO PRO LYS SER TYR ASN LYS ASP LEU GLU SER ALA          
SEQRES  40 V  533  GLU GLU ARG ARG GLU ARG GLU GLN GLN ASP LEU GLU PHE          
SEQRES  41 V  533  ALA LYS GLU MET ALA GLU ASP ASP ASP ASP SER PHE PRO          
SEQRES   1 W  456  MET ALA ASP GLY GLY SER GLU ARG ALA ASP GLY ARG ILE          
SEQRES   2 W  456  VAL LYS MET GLU VAL ASP TYR SER ALA THR VAL ASP GLN          
SEQRES   3 W  456  ARG LEU PRO GLU CYS ALA LYS LEU ALA LYS GLU GLY ARG          
SEQRES   4 W  456  LEU GLN GLU VAL ILE GLU THR LEU LEU SER LEU GLU LYS          
SEQRES   5 W  456  GLN THR ARG THR ALA SER ASP MET VAL SER THR SER ARG          
SEQRES   6 W  456  ILE LEU VAL ALA VAL VAL LYS MET CYS TYR GLU ALA LYS          
SEQRES   7 W  456  GLU TRP ASP LEU LEU ASN GLU ASN ILE MET LEU LEU SER          
SEQRES   8 W  456  LYS ARG ARG SER GLN LEU LYS GLN ALA VAL ALA LYS MET          
SEQRES   9 W  456  VAL GLN GLN CYS CYS THR TYR VAL GLU GLU ILE THR ASP          
SEQRES  10 W  456  LEU PRO ILE LYS LEU ARG LEU ILE ASP THR LEU ARG MET          
SEQRES  11 W  456  VAL THR GLU GLY LYS ILE TYR VAL GLU ILE GLU ARG ALA          
SEQRES  12 W  456  ARG LEU THR LYS THR LEU ALA THR ILE LYS GLU GLN ASN          
SEQRES  13 W  456  GLY ASP VAL LYS GLU ALA ALA SER ILE LEU GLN GLU LEU          
SEQRES  14 W  456  GLN VAL GLU THR TYR GLY SER MET GLU LYS LYS GLU ARG          
SEQRES  15 W  456  VAL GLU PHE ILE LEU GLU GLN MET ARG LEU CYS LEU ALA          
SEQRES  16 W  456  VAL LYS ASP TYR ILE ARG THR GLN ILE ILE SER LYS LYS          
SEQRES  17 W  456  ILE ASN THR LYS PHE PHE GLN GLU GLU ASN THR GLU LYS          
SEQRES  18 W  456  LEU LYS LEU LYS TYR TYR ASN LEU MET ILE GLN LEU ASP          
SEQRES  19 W  456  GLN HIS GLU GLY SER TYR LEU SER ILE CYS LYS HIS TYR          
SEQRES  20 W  456  ARG ALA ILE TYR ASP THR PRO CYS ILE GLN ALA GLU SER          
SEQRES  21 W  456  GLU LYS TRP GLN GLN ALA LEU LYS SER VAL VAL LEU TYR          
SEQRES  22 W  456  VAL ILE LEU ALA PRO PHE ASP ASN GLU GLN SER ASP LEU          
SEQRES  23 W  456  VAL HIS ARG ILE SER GLY ASP LYS LYS LEU GLU GLU ILE          
SEQRES  24 W  456  PRO LYS TYR LYS ASP LEU LEU LYS LEU PHE THR THR MET          
SEQRES  25 W  456  GLU LEU MET ARG TRP SER THR LEU VAL GLU ASP TYR GLY          
SEQRES  26 W  456  MET GLU LEU ARG LYS GLY SER LEU GLU SER PRO ALA THR          
SEQRES  27 W  456  ASP VAL PHE GLY SER THR GLU GLU GLY GLU LYS ARG TRP          
SEQRES  28 W  456  LYS ASP LEU LYS ASN ARG VAL VAL GLU HIS ASN ILE ARG          
SEQRES  29 W  456  ILE MET ALA LYS TYR TYR THR ARG ILE THR MET LYS ARG          
SEQRES  30 W  456  MET ALA GLN LEU LEU ASP LEU SER VAL ASP GLU SER GLU          
SEQRES  31 W  456  ALA PHE LEU SER ASN LEU VAL VAL ASN LYS THR ILE PHE          
SEQRES  32 W  456  ALA LYS VAL ASP ARG LEU ALA GLY ILE ILE ASN PHE GLN          
SEQRES  33 W  456  ARG PRO LYS ASP PRO ASN ASN LEU LEU ASN ASP TRP SER          
SEQRES  34 W  456  GLN LYS LEU ASN SER LEU MET SER LEU VAL ASN LYS THR          
SEQRES  35 W  456  THR HIS LEU ILE ALA LYS GLU GLU MET ILE HIS ASN LEU          
SEQRES  36 W  456  GLN                                                          
SEQRES   1 X  422  MET ALA ALA ALA ALA VAL VAL GLU PHE GLN ARG ALA GLN          
SEQRES   2 X  422  SER LEU LEU SER THR ASP ARG GLU ALA SER ILE ASP ILE          
SEQRES   3 X  422  LEU HIS SER ILE VAL LYS ARG ASP ILE GLN GLU ASN ASP          
SEQRES   4 X  422  GLU GLU ALA VAL GLN VAL LYS GLU GLN SER ILE LEU GLU          
SEQRES   5 X  422  LEU GLY SER LEU LEU ALA LYS THR GLY GLN ALA ALA GLU          
SEQRES   6 X  422  LEU GLY GLY LEU LEU LYS TYR VAL ARG PRO PHE LEU ASN          
SEQRES   7 X  422  SER ILE SER LYS ALA LYS ALA ALA ARG LEU VAL ARG SER          
SEQRES   8 X  422  LEU LEU ASP LEU PHE LEU ASP MET GLU ALA ALA THR GLY          
SEQRES   9 X  422  GLN GLU VAL GLU LEU CYS LEU GLU CYS ILE GLU TRP ALA          
SEQRES  10 X  422  LYS SER GLU LYS ARG THR PHE LEU ARG GLN ALA LEU GLU          
SEQRES  11 X  422  ALA ARG LEU VAL SER LEU TYR PHE ASP THR LYS ARG TYR          
SEQRES  12 X  422  GLN GLU ALA LEU HIS LEU GLY SER GLN LEU LEU ARG GLU          
SEQRES  13 X  422  LEU LYS LYS MET ASP ASP LYS ALA LEU LEU VAL GLU VAL          
SEQRES  14 X  422  GLN LEU LEU GLU SER LYS THR TYR HIS ALA LEU SER ASN          
SEQRES  15 X  422  LEU PRO LYS ALA ARG ALA ALA LEU THR SER ALA ARG THR          
SEQRES  16 X  422  THR ALA ASN ALA ILE TYR CYS PRO PRO LYS LEU GLN ALA          
SEQRES  17 X  422  THR LEU ASP MET GLN SER GLY ILE ILE HIS ALA ALA GLU          
SEQRES  18 X  422  GLU LYS ASP TRP LYS THR ALA TYR SER TYR PHE TYR GLU          
SEQRES  19 X  422  ALA PHE GLU GLY TYR ASP SER ILE ASP SER PRO LYS ALA          
SEQRES  20 X  422  ILE THR SER LEU LYS TYR MET LEU LEU CYS LYS ILE MET          
SEQRES  21 X  422  LEU ASN THR PRO GLU ASP VAL GLN ALA LEU VAL SER GLY          
SEQRES  22 X  422  LYS LEU ALA LEU ARG TYR ALA GLY ARG GLN THR GLU ALA          
SEQRES  23 X  422  LEU LYS CYS VAL ALA GLN ALA SER LYS ASN ARG SER LEU          
SEQRES  24 X  422  ALA ASP PHE GLU LYS ALA LEU THR ASP TYR ARG ALA GLU          
SEQRES  25 X  422  LEU ARG ASP ASP PRO ILE ILE SER THR HIS LEU ALA LYS          
SEQRES  26 X  422  LEU TYR ASP ASN LEU LEU GLU GLN ASN LEU ILE ARG VAL          
SEQRES  27 X  422  ILE GLU PRO PHE SER ARG VAL GLN ILE GLU HIS ILE SER          
SEQRES  28 X  422  SER LEU ILE LYS LEU SER LYS ALA ASP VAL GLU ARG LYS          
SEQRES  29 X  422  LEU SER GLN MET ILE LEU ASP LYS LYS PHE HIS GLY ILE          
SEQRES  30 X  422  LEU ASP GLN GLY GLU GLY VAL LEU ILE ILE PHE ASP GLU          
SEQRES  31 X  422  PRO PRO VAL ASP LYS THR TYR GLU ALA ALA LEU GLU THR          
SEQRES  32 X  422  ILE GLN ASN MET SER LYS VAL VAL ASP SER LEU TYR ASN          
SEQRES  33 X  422  LYS ALA LYS LYS LEU THR                                      
SEQRES   1 Y  389  MET PRO LEU GLU ASN LEU GLU GLU GLU GLY LEU PRO LYS          
SEQRES   2 Y  389  ASN PRO ASP LEU ARG ILE ALA GLN LEU ARG PHE LEU LEU          
SEQRES   3 Y  389  SER LEU PRO GLU HIS ARG GLY ASP ALA ALA VAL ARG ASP          
SEQRES   4 Y  389  GLU LEU MET ALA ALA VAL ARG ASP ASN ASN MET ALA PRO          
SEQRES   5 Y  389  TYR TYR GLU ALA LEU CYS LYS SER LEU ASP TRP GLN ILE          
SEQRES   6 Y  389  ASP VAL ASP LEU LEU ASN LYS MET LYS LYS ALA ASN GLU          
SEQRES   7 Y  389  ASP GLU LEU LYS ARG LEU ASP GLU GLU LEU GLU ASP ALA          
SEQRES   8 Y  389  GLU LYS ASN LEU GLY GLU SER GLU ILE ARG ASP ALA MET          
SEQRES   9 Y  389  MET ALA LYS ALA GLU TYR LEU CYS ARG ILE GLY ASP LYS          
SEQRES  10 Y  389  GLU GLY ALA LEU THR ALA PHE ARG LYS THR TYR ASP LYS          
SEQRES  11 Y  389  THR VAL ALA LEU GLY HIS ARG LEU ASP ILE VAL PHE TYR          
SEQRES  12 Y  389  LEU LEU ARG ILE GLY LEU PHE TYR MET ASP ASN ASP LEU          
SEQRES  13 Y  389  ILE THR ARG ASN THR GLU LYS ALA LYS SER LEU ILE GLU          
SEQRES  14 Y  389  GLU GLY GLY ASP TRP ASP ARG ARG ASN ARG LEU LYS VAL          
SEQRES  15 Y  389  TYR GLN GLY LEU TYR CYS VAL ALA ILE ARG ASP PHE LYS          
SEQRES  16 Y  389  GLN ALA ALA GLU LEU PHE LEU ASP THR VAL SER THR PHE          
SEQRES  17 Y  389  THR SER TYR GLU LEU MET ASP TYR LYS THR PHE VAL THR          
SEQRES  18 Y  389  TYR THR VAL TYR VAL SER MET ILE ALA LEU GLU ARG PRO          
SEQRES  19 Y  389  ASP LEU ARG GLU LYS VAL ILE LYS GLY ALA GLU ILE LEU          
SEQRES  20 Y  389  GLU VAL LEU HIS SER LEU PRO ALA VAL ARG GLN TYR LEU          
SEQRES  21 Y  389  PHE SER LEU TYR GLU CYS ARG TYR SER VAL PHE PHE GLN          
SEQRES  22 Y  389  SER LEU ALA VAL VAL GLU GLN GLU MET LYS LYS ASP TRP          
SEQRES  23 Y  389  LEU PHE ALA PRO HIS TYR ARG TYR TYR VAL ARG GLU MET          
SEQRES  24 Y  389  ARG ILE HIS ALA TYR SER GLN LEU LEU GLU SER TYR ARG          
SEQRES  25 Y  389  SER LEU THR LEU GLY TYR MET ALA GLU ALA PHE GLY VAL          
SEQRES  26 Y  389  GLY VAL GLU PHE ILE ASP GLN GLU LEU SER ARG PHE ILE          
SEQRES  27 Y  389  ALA ALA GLY ARG LEU HIS CYS LYS ILE ASP LYS VAL ASN          
SEQRES  28 Y  389  GLU ILE VAL GLU THR ASN ARG PRO ASP SER LYS ASN TRP          
SEQRES  29 Y  389  GLN TYR GLN GLU THR ILE LYS LYS GLY ASP LEU LEU LEU          
SEQRES  30 Y  389  ASN ARG VAL GLN LYS LEU SER ARG VAL ILE ASN MET              
SEQRES   1 Z  324  MET PRO GLU LEU ALA VAL GLN LYS VAL VAL VAL HIS PRO          
SEQRES   2 Z  324  LEU VAL LEU LEU SER VAL VAL ASP HIS PHE ASN ARG ILE          
SEQRES   3 Z  324  GLY LYS VAL GLY ASN GLN LYS ARG VAL VAL GLY VAL LEU          
SEQRES   4 Z  324  LEU GLY SER TRP GLN LYS LYS VAL LEU ASP VAL SER ASN          
SEQRES   5 Z  324  SER PHE ALA VAL PRO PHE ASP GLU ASP ASP LYS ASP ASP          
SEQRES   6 Z  324  SER VAL TRP PHE LEU ASP HIS ASP TYR LEU GLU ASN MET          
SEQRES   7 Z  324  TYR GLY MET PHE LYS LYS VAL ASN ALA ARG GLU ARG ILE          
SEQRES   8 Z  324  VAL GLY TRP TYR HIS THR GLY PRO LYS LEU HIS LYS ASN          
SEQRES   9 Z  324  ASP ILE ALA ILE ASN GLU LEU MET LYS ARG TYR CYS PRO          
SEQRES  10 Z  324  ASN SER VAL LEU VAL ILE ILE ASP VAL LYS PRO LYS ASP          
SEQRES  11 Z  324  LEU GLY LEU PRO THR GLU ALA TYR ILE SER VAL GLU GLU          
SEQRES  12 Z  324  VAL HIS ASP ASP GLY THR PRO THR SER LYS THR PHE GLU          
SEQRES  13 Z  324  HIS VAL THR SER GLU ILE GLY ALA GLU GLU ALA GLU GLU          
SEQRES  14 Z  324  VAL GLY VAL GLU HIS LEU LEU ARG ASP ILE LYS ASP THR          
SEQRES  15 Z  324  THR VAL GLY THR LEU SER GLN ARG ILE THR ASN GLN VAL          
SEQRES  16 Z  324  HIS GLY LEU LYS GLY LEU ASN SER LYS LEU LEU ASP ILE          
SEQRES  17 Z  324  ARG SER TYR LEU GLU LYS VAL ALA THR GLY LYS LEU PRO          
SEQRES  18 Z  324  ILE ASN HIS GLN ILE ILE TYR GLN LEU GLN ASP VAL PHE          
SEQRES  19 Z  324  ASN LEU LEU PRO ASP VAL SER LEU GLN GLU PHE VAL LYS          
SEQRES  20 Z  324  ALA PHE TYR LEU LYS THR ASN ASP GLN MET VAL VAL VAL          
SEQRES  21 Z  324  TYR LEU ALA SER LEU ILE ARG SER VAL VAL ALA LEU HIS          
SEQRES  22 Z  324  ASN LEU ILE ASN ASN LYS ILE ALA ASN ARG ASP ALA GLU          
SEQRES  23 Z  324  LYS LYS GLU GLY GLN GLU LYS GLU GLU SER LYS LYS ASP          
SEQRES  24 Z  324  ARG LYS GLU ASP LYS GLU LYS ASP LYS ASP LYS GLU LYS          
SEQRES  25 Z  324  SER ASP VAL LYS LYS GLU GLU LYS LYS GLU LYS LYS              
SEQRES   1 a  376  MET LYS ASP VAL PRO GLY PHE LEU GLN GLN SER GLN ASN          
SEQRES   2 a  376  SER GLY PRO GLY GLN PRO ALA VAL TRP HIS ARG LEU GLU          
SEQRES   3 a  376  GLU LEU TYR THR LYS LYS LEU TRP HIS GLN LEU THR LEU          
SEQRES   4 a  376  GLN VAL LEU ASP PHE VAL GLN ASP PRO CYS PHE ALA GLN          
SEQRES   5 a  376  GLY ASP GLY LEU ILE LYS LEU TYR GLU ASN PHE ILE SER          
SEQRES   6 a  376  GLU PHE GLU HIS ARG VAL ASN PRO LEU SER LEU VAL GLU          
SEQRES   7 a  376  ILE ILE LEU HIS VAL VAL ARG GLN MET THR ASP PRO ASN          
SEQRES   8 a  376  VAL ALA LEU THR PHE LEU GLU LYS THR ARG GLU LYS VAL          
SEQRES   9 a  376  LYS SER SER ASP GLU ALA VAL ILE LEU CYS LYS THR ALA          
SEQRES  10 a  376  ILE GLY ALA LEU LYS LEU ASN ILE GLY ASP LEU GLN VAL          
SEQRES  11 a  376  THR LYS GLU THR ILE GLU ASP VAL GLU GLU MET LEU ASN          
SEQRES  12 a  376  ASN LEU PRO GLY VAL THR SER VAL HIS SER ARG PHE TYR          
SEQRES  13 a  376  ASP LEU SER SER LYS TYR TYR GLN THR ILE GLY ASN HIS          
SEQRES  14 a  376  ALA SER TYR TYR LYS ASP ALA LEU ARG PHE LEU GLY CYS          
SEQRES  15 a  376  VAL ASP ILE LYS ASP LEU PRO VAL SER GLU GLN GLN GLU          
SEQRES  16 a  376  ARG ALA PHE THR LEU GLY LEU ALA GLY LEU LEU GLY GLU          
SEQRES  17 a  376  GLY VAL PHE ASN PHE GLY GLU LEU LEU MET HIS PRO VAL          
SEQRES  18 a  376  LEU GLU SER LEU ARG ASN THR ASP ARG GLN TRP LEU ILE          
SEQRES  19 a  376  ASP THR LEU TYR ALA PHE ASN SER GLY ASN VAL GLU ARG          
SEQRES  20 a  376  PHE GLN THR LEU LYS THR ALA TRP GLY GLN GLN PRO ASP          
SEQRES  21 a  376  LEU ALA ALA ASN GLU ALA GLN LEU LEU ARG LYS ILE GLN          
SEQRES  22 a  376  LEU LEU CYS LEU MET GLU MET THR PHE THR ARG PRO ALA          
SEQRES  23 a  376  ASN HIS ARG GLN LEU THR PHE GLU GLU ILE ALA LYS SER          
SEQRES  24 a  376  ALA LYS ILE THR VAL ASN GLU VAL GLU LEU LEU VAL MET          
SEQRES  25 a  376  LYS ALA LEU SER VAL GLY LEU VAL LYS GLY SER ILE ASP          
SEQRES  26 a  376  GLU VAL ASP LYS ARG VAL HIS MET THR TRP VAL GLN PRO          
SEQRES  27 a  376  ARG VAL LEU ASP LEU GLN GLN ILE LYS GLY MET LYS ASP          
SEQRES  28 a  376  ARG LEU GLU PHE TRP CYS THR ASP VAL LYS SER MET GLU          
SEQRES  29 a  376  MET LEU VAL GLU HIS GLN ALA HIS ASP ILE LEU THR              
SEQRES   1 b  377  MET VAL LEU GLU SER THR MET VAL CYS VAL ASP ASN SER          
SEQRES   2 b  377  GLU TYR MET ARG ASN GLY ASP PHE LEU PRO THR ARG LEU          
SEQRES   3 b  377  GLN ALA GLN GLN ASP ALA VAL ASN ILE VAL CYS HIS SER          
SEQRES   4 b  377  LYS THR ARG SER ASN PRO GLU ASN ASN VAL GLY LEU ILE          
SEQRES   5 b  377  THR LEU ALA ASN ASP CYS GLU VAL LEU THR THR LEU THR          
SEQRES   6 b  377  PRO ASP THR GLY ARG ILE LEU SER LYS LEU HIS THR VAL          
SEQRES   7 b  377  GLN PRO LYS GLY LYS ILE THR PHE CYS THR GLY ILE ARG          
SEQRES   8 b  377  VAL ALA HIS LEU ALA LEU LYS HIS ARG GLN GLY LYS ASN          
SEQRES   9 b  377  HIS LYS MET ARG ILE ILE ALA PHE VAL GLY SER PRO VAL          
SEQRES  10 b  377  GLU ASP ASN GLU LYS ASP LEU VAL LYS LEU ALA LYS ARG          
SEQRES  11 b  377  LEU LYS LYS GLU LYS VAL ASN VAL ASP ILE ILE ASN PHE          
SEQRES  12 b  377  GLY GLU GLU GLU VAL ASN THR GLU LYS LEU THR ALA PHE          
SEQRES  13 b  377  VAL ASN THR LEU ASN GLY LYS ASP GLY THR GLY SER HIS          
SEQRES  14 b  377  LEU VAL THR VAL PRO PRO GLY PRO SER LEU ALA ASP ALA          
SEQRES  15 b  377  LEU ILE SER SER PRO ILE LEU ALA GLY GLU GLY GLY ALA          
SEQRES  16 b  377  MET LEU GLY LEU GLY ALA SER ASP PHE GLU PHE GLY VAL          
SEQRES  17 b  377  ASP PRO SER ALA ASP PRO GLU LEU ALA LEU ALA LEU ARG          
SEQRES  18 b  377  VAL SER MET GLU GLU GLN ARG GLN ARG GLN GLU GLU GLU          
SEQRES  19 b  377  ALA ARG ARG ALA ALA ALA ALA SER ALA ALA GLU ALA GLY          
SEQRES  20 b  377  ILE ALA THR THR GLY THR GLU ASP SER ASP ASP ALA LEU          
SEQRES  21 b  377  LEU LYS MET THR ILE SER GLN GLN GLU PHE GLY ARG THR          
SEQRES  22 b  377  GLY LEU PRO ASP LEU SER SER MET THR GLU GLU GLU GLN          
SEQRES  23 b  377  ILE ALA TYR ALA MET GLN MET SER LEU GLN GLY ALA GLU          
SEQRES  24 b  377  PHE GLY GLN ALA GLU SER ALA ASP ILE ASP ALA SER SER          
SEQRES  25 b  377  ALA MET ASP THR SER GLU PRO ALA LYS GLU GLU ASP ASP          
SEQRES  26 b  377  TYR ASP VAL MET GLN ASP PRO GLU PHE LEU GLN SER VAL          
SEQRES  27 b  377  LEU GLU ASN LEU PRO GLY VAL ASP PRO ASN ASN GLU ALA          
SEQRES  28 b  377  ILE ARG ASN ALA MET GLY SER LEU ALA SER GLN ALA THR          
SEQRES  29 b  377  LYS ASP GLY LYS LYS ASP LYS LYS GLU GLU ASP LYS LYS          
SEQRES   1 c  309  ASP ARG LEU LEU ARG LEU GLY GLY GLY MET PRO GLY LEU          
SEQRES   2 c  309  GLY GLN GLY PRO PRO THR ASP ALA PRO ALA VAL ASP THR          
SEQRES   3 c  309  ALA GLU GLN VAL TYR ILE SER SER LEU ALA LEU LEU LYS          
SEQRES   4 c  309  MET LEU LYS HIS GLY ARG ALA GLY VAL PRO MET GLU VAL          
SEQRES   5 c  309  MET GLY LEU MET LEU GLY GLU PHE VAL ASP ASP TYR THR          
SEQRES   6 c  309  VAL ARG VAL ILE ASP VAL PHE ALA MET PRO GLN SER GLY          
SEQRES   7 c  309  THR GLY VAL SER VAL GLU ALA VAL ASP PRO VAL PHE GLN          
SEQRES   8 c  309  ALA LYS MET LEU ASP MET LEU LYS GLN THR GLY ARG PRO          
SEQRES   9 c  309  GLU MET VAL VAL GLY TRP TYR HIS SER HIS PRO GLY PHE          
SEQRES  10 c  309  GLY CYS TRP LEU SER GLY VAL ASP ILE ASN THR GLN GLN          
SEQRES  11 c  309  SER PHE GLU ALA LEU SER GLU ARG ALA VAL ALA VAL VAL          
SEQRES  12 c  309  VAL ASP PRO ILE GLN SER VAL LYS GLY LYS VAL VAL ILE          
SEQRES  13 c  309  ASP ALA PHE ARG LEU ILE ASN ALA ASN MET MET VAL LEU          
SEQRES  14 c  309  GLY HIS GLU PRO ARG GLN THR THR SER ASN LEU GLY HIS          
SEQRES  15 c  309  LEU ASN LYS PRO SER ILE GLN ALA LEU ILE HIS GLY LEU          
SEQRES  16 c  309  ASN ARG HIS TYR TYR SER ILE THR ILE ASN TYR ARG LYS          
SEQRES  17 c  309  ASN GLU LEU GLU GLN LYS MET LEU LEU ASN LEU HIS LYS          
SEQRES  18 c  309  LYS SER TRP MET GLU GLY LEU THR LEU GLN ASP TYR SER          
SEQRES  19 c  309  GLU HIS CYS LYS HIS ASN GLU SER VAL VAL LYS GLU MET          
SEQRES  20 c  309  LEU GLU LEU ALA LYS ASN TYR ASN LYS ALA VAL GLU GLU          
SEQRES  21 c  309  GLU ASP LYS MET THR PRO GLU GLN LEU ALA ILE LYS ASN          
SEQRES  22 c  309  VAL GLY LYS GLN ASP PRO LYS ARG HIS LEU GLU GLU HIS          
SEQRES  23 c  309  VAL ASP VAL LEU MET THR SER ASN ILE VAL GLN CYS LEU          
SEQRES  24 c  309  ALA ALA MET LEU ASP THR VAL VAL PHE LYS                      
SEQRES   1 d  349  PHE ILE LYS GLY ARG ALA PRO ARG ALA PRO PRO ARG GLU          
SEQRES   2 d  349  ARG ARG ARG ALA THR ARG GLY GLY LEU ARG GLN VAL VAL          
SEQRES   3 d  349  ALA PRO PRO ARG ALA LEU GLY SER THR SER ARG PRO HIS          
SEQRES   4 d  349  PHE ARG ARG ALA SER VAL CYS ARG ARG ARG CYS ARG LYS          
SEQRES   5 d  349  SER GLY GLY LEU LEU ALA ALA SER ARG LYS MET ALA ALA          
SEQRES   6 d  349  ALA ALA VAL ASN GLY ALA ALA GLY PHE SER SER SER GLY          
SEQRES   7 d  349  PRO ALA ALA THR SER GLY ALA VAL LEU GLN ALA ALA THR          
SEQRES   8 d  349  GLY MET TYR GLU GLN LEU LYS GLY GLU TRP ASN ARG LYS          
SEQRES   9 d  349  SER PRO ASN LEU SER LYS CYS GLY GLU GLU LEU GLY ARG          
SEQRES  10 d  349  LEU LYS LEU VAL LEU LEU GLU LEU ASN PHE LEU PRO THR          
SEQRES  11 d  349  THR GLY THR LYS LEU THR LYS GLN GLN LEU ILE LEU ALA          
SEQRES  12 d  349  ARG ASP ILE LEU GLU ILE GLY ALA GLN TRP SER ILE LEU          
SEQRES  13 d  349  ARG LYS ASP ILE PRO SER PHE GLU ARG TYR MET ALA GLN          
SEQRES  14 d  349  LEU LYS CYS TYR TYR PHE ASP TYR LYS GLU GLN LEU PRO          
SEQRES  15 d  349  GLU SER ALA TYR MET HIS GLN LEU LEU GLY LEU ASN LEU          
SEQRES  16 d  349  LEU PHE LEU LEU SER GLN ASN ARG VAL ALA GLU PHE HIS          
SEQRES  17 d  349  THR GLU LEU GLU ARG LEU PRO ALA LYS ASP ILE GLN THR          
SEQRES  18 d  349  ASN VAL TYR ILE LYS HIS PRO VAL SER LEU GLU GLN TYR          
SEQRES  19 d  349  LEU MET GLU GLY SER TYR ASN LYS VAL PHE LEU ALA LYS          
SEQRES  20 d  349  GLY ASN ILE PRO ALA GLU SER TYR THR PHE PHE ILE ASP          
SEQRES  21 d  349  ILE LEU LEU ASP THR ILE ARG ASP GLU ILE ALA GLY CYS          
SEQRES  22 d  349  ILE GLU LYS ALA TYR GLU LYS ILE LEU PHE THR GLU ALA          
SEQRES  23 d  349  THR ARG ILE LEU PHE PHE ASN THR PRO LYS LYS MET THR          
SEQRES  24 d  349  ASP TYR ALA LYS LYS ARG GLY TRP VAL LEU GLY PRO ASN          
SEQRES  25 d  349  ASN TYR TYR SER PHE ALA SER GLN GLN GLN LYS PRO GLU          
SEQRES  26 d  349  ASP THR THR ILE PRO SER THR GLU LEU ALA LYS GLN VAL          
SEQRES  27 d  349  ILE GLU TYR ALA ARG GLN LEU GLU MET ILE VAL                  
SEQRES   1 e   70  MET SER GLU LYS LYS GLN PRO VAL ASP LEU GLY LEU LEU          
SEQRES   2 e   70  GLU GLU ASP ASP GLU PHE GLU GLU PHE PRO ALA GLU ASP          
SEQRES   3 e   70  TRP ALA GLY LEU ASP GLU ASP GLU ASP ALA HIS VAL TRP          
SEQRES   4 e   70  GLU ASP ASN TRP ASP ASP ASP ASN VAL GLU ASP ASP PHE          
SEQRES   5 e   70  SER ASN GLN LEU ARG ALA GLU LEU GLU LYS HIS GLY TYR          
SEQRES   6 e   70  LYS MET GLU THR SER                                          
SEQRES   1 f  749  MET SER MET SER GLY GLU VAL ALA LYS GLU TRP GLN GLU          
SEQRES   2 f  749  LEU ASP ASP ALA GLU LYS VAL GLN ARG GLU PRO LEU LEU          
SEQRES   3 f  749  THR LEU VAL LYS GLU ILE VAL PRO TYR ASN MET ALA HIS          
SEQRES   4 f  749  ASN ALA GLU HIS GLU ALA CYS ASP LEU LEU MET GLU ILE          
SEQRES   5 f  749  GLU GLN VAL ASP MET LEU GLU LYS ASP ILE ASP GLU ASN          
SEQRES   6 f  749  ALA TYR ALA LYS VAL CYS LEU TYR LEU THR SER CYS VAL          
SEQRES   7 f  749  ASN TYR VAL PRO GLU PRO GLU ASN SER ALA LEU LEU ARG          
SEQRES   8 f  749  CYS ALA LEU GLY VAL PHE ARG LYS PHE SER ARG PHE PRO          
SEQRES   9 f  749  GLU ALA LEU ARG LEU ALA LEU MET LEU ASN ASP MET GLU          
SEQRES  10 f  749  LEU VAL GLU ASP ILE PHE THR SER CYS LYS ASP VAL VAL          
SEQRES  11 f  749  VAL GLN LYS GLN MET ALA PHE MET LEU GLY ARG HIS GLY          
SEQRES  12 f  749  VAL PHE LEU GLU LEU SER GLU ASP VAL GLU GLU TYR GLU          
SEQRES  13 f  749  ASP LEU THR GLU ILE MET SER ASN VAL GLN LEU ASN SER          
SEQRES  14 f  749  ASN PHE LEU ALA LEU ALA ARG GLU LEU ASP ILE MET GLU          
SEQRES  15 f  749  PRO LYS VAL PRO ASP ASP ILE TYR LYS THR HIS LEU GLU          
SEQRES  16 f  749  ASN ASN ARG PHE GLY GLY SER GLY SER GLN VAL ASP SER          
SEQRES  17 f  749  ALA ARG MET ASN LEU ALA SER SER PHE VAL ASN GLY PHE          
SEQRES  18 f  749  VAL ASN ALA ALA PHE GLY GLN ASP LYS LEU LEU THR ASP          
SEQRES  19 f  749  ASP GLY ASN LYS TRP LEU TYR LYS ASN LYS ASP HIS GLY          
SEQRES  20 f  749  MET LEU SER ALA ALA ALA SER LEU GLY MET ILE LEU LEU          
SEQRES  21 f  749  TRP ASP VAL ASP GLY GLY LEU THR GLN ILE ASP LYS TYR          
SEQRES  22 f  749  LEU TYR SER SER GLU ASP TYR ILE LYS SER GLY ALA LEU          
SEQRES  23 f  749  LEU ALA CYS GLY ILE VAL ASN SER GLY VAL ARG ASN GLU          
SEQRES  24 f  749  CYS ASP PRO ALA LEU ALA LEU LEU SER ASP TYR VAL LEU          
SEQRES  25 f  749  HIS ASN SER ASN THR MET ARG LEU GLY SER ILE PHE GLY          
SEQRES  26 f  749  LEU GLY LEU ALA TYR ALA GLY SER ASN ARG GLU ASP VAL          
SEQRES  27 f  749  LEU THR LEU LEU LEU PRO VAL MET GLY ASP SER LYS SER          
SEQRES  28 f  749  SER MET GLU VAL ALA GLY VAL THR ALA LEU ALA CYS GLY          
SEQRES  29 f  749  MET ILE ALA VAL GLY SER CYS ASN GLY ASP VAL THR SER          
SEQRES  30 f  749  THR ILE LEU GLN THR ILE MET GLU LYS SER GLU THR GLU          
SEQRES  31 f  749  LEU LYS ASP THR TYR ALA ARG TRP LEU PRO LEU GLY LEU          
SEQRES  32 f  749  GLY LEU ASN HIS LEU GLY LYS GLY GLU ALA ILE GLU ALA          
SEQRES  33 f  749  ILE LEU ALA ALA LEU GLU VAL VAL SER GLU PRO PHE ARG          
SEQRES  34 f  749  SER PHE ALA ASN THR LEU VAL ASP VAL CYS ALA TYR ALA          
SEQRES  35 f  749  GLY SER GLY ASN VAL LEU LYS VAL GLN GLN LEU LEU HIS          
SEQRES  36 f  749  ILE CYS SER GLU HIS PHE ASP SER LYS GLU LYS GLU GLU          
SEQRES  37 f  749  ASP LYS ASP LYS LYS GLU LYS LYS ASP LYS ASP LYS LYS          
SEQRES  38 f  749  GLU ALA PRO ALA ASP MET GLY ALA HIS GLN GLY VAL ALA          
SEQRES  39 f  749  VAL LEU GLY ILE ALA LEU ILE ALA MET GLY GLU GLU ILE          
SEQRES  40 f  749  GLY ALA GLU MET ALA LEU ARG THR PHE GLY HIS LEU LEU          
SEQRES  41 f  749  ARG TYR GLY GLU PRO THR LEU ARG ARG ALA VAL PRO LEU          
SEQRES  42 f  749  ALA LEU ALA LEU ILE SER VAL SER ASN PRO ARG LEU ASN          
SEQRES  43 f  749  ILE LEU ASP THR LEU SER LYS PHE SER HIS ASP ALA ASP          
SEQRES  44 f  749  PRO GLU VAL SER TYR ASN SER ILE PHE ALA MET GLY MET          
SEQRES  45 f  749  VAL GLY SER GLY THR ASN ASN ALA ARG LEU ALA ALA MET          
SEQRES  46 f  749  LEU ARG GLN LEU ALA GLN TYR HIS ALA LYS ASP PRO ASN          
SEQRES  47 f  749  ASN LEU PHE MET VAL ARG LEU ALA GLN GLY LEU THR HIS          
SEQRES  48 f  749  LEU GLY LYS GLY THR LEU THR LEU CYS PRO TYR HIS SER          
SEQRES  49 f  749  ASP ARG GLN LEU MET SER GLN VAL ALA VAL ALA GLY LEU          
SEQRES  50 f  749  LEU THR VAL LEU VAL SER PHE LEU ASP VAL ARG ASN ILE          
SEQRES  51 f  749  ILE LEU GLY LYS SER HIS TYR VAL LEU TYR GLY LEU VAL          
SEQRES  52 f  749  ALA ALA MET GLN PRO ARG MET LEU VAL THR PHE ASP GLU          
SEQRES  53 f  749  GLU LEU ARG PRO LEU PRO VAL SER VAL ARG VAL GLY GLN          
SEQRES  54 f  749  ALA VAL ASP VAL VAL GLY GLN ALA GLY LYS PRO LYS THR          
SEQRES  55 f  749  ILE THR GLY PHE GLN THR HIS THR THR PRO VAL LEU LEU          
SEQRES  56 f  749  ALA HIS GLY GLU ARG ALA GLU LEU ALA THR GLU GLU PHE          
SEQRES  57 f  749  LEU PRO VAL THR PRO ILE LEU GLU GLY PHE VAL ILE LEU          
SEQRES  58 f  749  ARG LYS ASN PRO ASN TYR ASP LEU                              
HET    ATP  A 501      31                                                       
HET    ATP  D 501      31                                                       
HET    ATP  E 401      31                                                       
HET    ATP  F 501      31                                                       
HET     ZN  c 401       1                                                       
HETNAM     ATP ADENOSINE-5'-TRIPHOSPHATE                                        
HETNAM      ZN ZINC ION                                                         
FORMUL  33  ATP    4(C10 H16 N5 O13 P3)                                         
FORMUL  37   ZN    ZN 2+                                                        
HELIX    1 AA1 ALA A   73  ALA A   81  1                                   9    
HELIX    2 AA2 ALA A   82  GLN A   91  1                                  10    
HELIX    3 AA3 LEU A   93  ARG A   97  5                                   5    
HELIX    4 AA4 ALA A  130  ILE A  134  5                                   5    
HELIX    5 AA5 THR A  173  VAL A  177  5                                   5    
HELIX    6 AA6 LYS A  181  GLU A  189  1                                   9    
HELIX    7 AA7 VAL A  191  HIS A  197  1                                   7    
HELIX    8 AA8 HIS A  197  GLY A  205  1                                   9    
HELIX    9 AA9 LYS A  222  ASN A  231  1                                  10    
HELIX   10 AB1 SER A  243  VAL A  246  5                                   4    
HELIX   11 AB2 GLY A  251  LYS A  268  1                                  18    
HELIX   12 AB3 GLU A  276  GLY A  281  1                                   6    
HELIX   13 AB4 GLY A  291  ASP A  307  1                                  17    
HELIX   14 AB5 THR A  326  LEU A  337  1                                  12    
HELIX   15 AB6 GLY A  350  ALA A  359  1                                  10    
HELIX   16 AB7 ARG A  369  ARG A  375  1                                   7    
HELIX   17 AB8 ILE A  385  ALA A  399  1                                  15    
HELIX   18 AB9 THR A  405  SER A  419  1                                  15    
HELIX   19 AC1 TYR A  420  LYS A  422  5                                   3    
HELIX   20 AC2 ARG A  428  ASN A  433  1                                   6    
HELIX   21 AC3 LYS B   98  GLY B  104  1                                   7    
HELIX   22 AC4 ASP B  140  GLU B  145  1                                   6    
HELIX   23 AC5 ASP B  168  VAL B  173  5                                   6    
HELIX   24 AC6 THR B  183  ILE B  187  5                                   5    
HELIX   25 AC7 ASP B  191  LEU B  203  1                                  13    
HELIX   26 AC8 PRO B  208  GLY B  215  1                                   8    
HELIX   27 AC9 GLY B  229  LEU B  234  1                                   6    
HELIX   28 AD1 LEU B  234  ASN B  241  1                                   8    
HELIX   29 AD2 LYS B  265  GLU B  275  1                                  11    
HELIX   30 AD3 ASP B  288  THR B  292  5                                   5    
HELIX   31 AD4 GLU B  302  ASP B  317  1                                  16    
HELIX   32 AD5 ASP B  357  THR B  369  1                                  13    
HELIX   33 AD6 LEU B  380  LYS B  387  1                                   8    
HELIX   34 AD7 GLY B  392  ALA B  406  1                                  15    
HELIX   35 AD8 LEU B  407  ARG B  410  5                                   4    
HELIX   36 AD9 THR B  415  GLY B  433  1                                  19    
HELIX   37 AE1 ALA C   16  LEU C   66  1                                  51    
HELIX   38 AE2 ASP C  104  VAL C  108  5                                   5    
HELIX   39 AE3 VAL C  131  VAL C  143  1                                  13    
HELIX   40 AE4 THR C  147  ILE C  151  5                                   5    
HELIX   41 AE5 LEU C  154  LYS C  170  1                                  17    
HELIX   42 AE6 HIS C  171  GLU C  173  5                                   3    
HELIX   43 AE7 LEU C  174  GLY C  179  1                                   6    
HELIX   44 AE8 LEU C  199  THR C  207  1                                   9    
HELIX   45 AE9 MET C  230  HIS C  241  1                                  12    
HELIX   46 AF1 GLU C  268  PHE C  283  1                                  16    
HELIX   47 AF2 ASP C  299  ARG C  307  1                                   9    
HELIX   48 AF3 ASN C  321  SER C  333  1                                  13    
HELIX   49 AF4 ASN C  343  LEU C  350  1                                   8    
HELIX   50 AF5 GLY C  356  LEU C  371  1                                  16    
HELIX   51 AF6 THR C  379  LYS C  393  1                                  15    
HELIX   52 AF7 LEU D   40  LEU D   47  1                                   8    
HELIX   53 AF8 LEU D   47  ILE D   82  1                                  36    
HELIX   54 AF9 MET D  163  GLY D  168  5                                   6    
HELIX   55 AG1 ASP D  171  VAL D  181  1                                  11    
HELIX   56 AG2 VAL D  181  THR D  186  1                                   6    
HELIX   57 AG3 PHE D  188  GLY D  195  1                                   8    
HELIX   58 AG4 LYS D  212  THR D  223  1                                  12    
HELIX   59 AG5 GLU D  242  ASN D  257  1                                  16    
HELIX   60 AG6 THR D  279  ASP D  297  1                                  19    
HELIX   61 AG7 ASP D  318  ARG D  323  1                                   6    
HELIX   62 AG8 ARG D  338  MET D  352  1                                  15    
HELIX   63 AG9 ALA D  365  SER D  371  1                                   7    
HELIX   64 AH1 SER D  377  LEU D  385  1                                   9    
HELIX   65 AH2 LEU D  395  VAL D  406  1                                  12    
HELIX   66 AH3 HIS D  414  LYS D  418  5                                   5    
HELIX   67 AH4 LYS E   38  GLN E   51  1                                  14    
HELIX   68 AH5 ASP E   88  LEU E   92  5                                   5    
HELIX   69 AH6 PRO E  117  SER E  123  1                                   7    
HELIX   70 AH7 ASN E  129  GLU E  134  1                                   6    
HELIX   71 AH8 LEU E  138  GLU E  150  1                                  13    
HELIX   72 AH9 GLU E  150  ASN E  155  1                                   6    
HELIX   73 AI1 PRO E  156  GLY E  163  1                                   8    
HELIX   74 AI2 GLY E  179  LEU E  191  1                                  13    
HELIX   75 AI3 SER E  200  ASP E  205  1                                   6    
HELIX   76 AI4 GLU E  210  ASP E  224  1                                  15    
HELIX   77 AI5 GLU E  234  GLY E  239  1                                   6    
HELIX   78 AI6 SER E  248  ASP E  265  1                                  18    
HELIX   79 AI7 LEU E  285  ARG E  291  1                                   7    
HELIX   80 AI8 ALA E  308  GLY E  318  1                                  11    
HELIX   81 AI9 TYR E  328  LEU E  334  1                                   7    
HELIX   82 AJ1 ASN E  339  MET E  352  1                                  14    
HELIX   83 AJ2 VAL E  363  LEU E  380  1                                  18    
HELIX   84 AJ3 HIS F   64  THR F   85  1                                  22    
HELIX   85 AJ4 GLN F  184  ILE F  188  5                                   5    
HELIX   86 AJ5 LEU F  191  HIS F  208  1                                  18    
HELIX   87 AJ6 HIS F  208  GLY F  216  1                                   9    
HELIX   88 AJ7 GLY F  232  THR F  244  1                                  13    
HELIX   89 AJ8 GLY F  253  VAL F  257  5                                   5    
HELIX   90 AJ9 ASP F  263  LYS F  278  1                                  16    
HELIX   91 AK1 GLU F  287  GLY F  292  1                                   6    
HELIX   92 AK2 ASP F  303  LEU F  314  1                                  12    
HELIX   93 AK3 LEU F  314  PHE F  320  1                                   7    
HELIX   94 AK4 GLN F  321  GLN F  325  5                                   5    
HELIX   95 AK5 ASP F  339  LEU F  343  5                                   5    
HELIX   96 AK6 ASN F  358  SER F  370  1                                  13    
HELIX   97 AK7 GLU F  382  CYS F  387  1                                   6    
HELIX   98 AK8 ASN F  392  GLY F  411  1                                  20    
HELIX   99 AK9 THR F  416  GLN F  428  1                                  13    
HELIX  100 AL1 PHE G    9  ILE G   13  5                                   5    
HELIX  101 AL2 TYR G   23  ALA G   28  1                                   6    
HELIX  102 AL3 MET G   83  TYR G  105  1                                  23    
HELIX  103 AL4 MET G  113  ASN G  128  1                                  16    
HELIX  104 AL5 LYS G  171  LYS G  184  1                                  14    
HELIX  105 AL6 THR G  190  THR G  204  1                                  15    
HELIX  106 AL7 GLU G  234  ALA G  243  1                                  10    
HELIX  107 AL8 VAL H   20  GLY H   31  1                                  12    
HELIX  108 AL9 ASP H   82  GLN H  102  1                                  21    
HELIX  109 AM1 PRO H  106  SER H  124  1                                  19    
HELIX  110 AM2 ASN H  166  ARG H  177  1                                  12    
HELIX  111 AM3 GLU H  183  PHE H  199  1                                  17    
HELIX  112 AM4 THR H  222  LEU H  230  1                                   9    
HELIX  113 AM5 LEU I   18  HIS I   30  1                                  13    
HELIX  114 AM6 ILE I   79  GLN I  102  1                                  24    
HELIX  115 AM7 PRO I  106  PHE I  124  1                                  19    
HELIX  116 AM8 SER I  168  ASP I  178  1                                  11    
HELIX  117 AM9 THR I  185  MET I  201  1                                  17    
HELIX  118 AN1 GLN I  230  GLU I  248  1                                  19    
HELIX  119 AN2 VAL J   19  LYS J   28  1                                  10    
HELIX  120 AN3 THR J   77  THR J   97  1                                  21    
HELIX  121 AN4 ILE J  107  TYR J  118  1                                  12    
HELIX  122 AN5 ALA J  165  LYS J  174  1                                  10    
HELIX  123 AN6 ASN J  175  THR J  177  5                                   3    
HELIX  124 AN7 THR J  183  VAL J  198  1                                  16    
HELIX  125 AN8 GLU J  223  ASN J  239  1                                  17    
HELIX  126 AN9 LEU K   21  ALA K   30  1                                  10    
HELIX  127 AO1 ILE K   82  TYR K  103  1                                  22    
HELIX  128 AO2 GLU K  110  LEU K  119  1                                  10    
HELIX  129 AO3 ALA K  173  GLN K  182  1                                  10    
HELIX  130 AO4 THR K  190  MET K  206  1                                  17    
HELIX  131 AO5 GLU K  235  ASP K  240  1                                   6    
HELIX  132 AO6 ASN L    4  ASN L    8  5                                   5    
HELIX  133 AO7 ILE L   19  GLN L   31  1                                  13    
HELIX  134 AO8 THR L   78  VAL L   98  1                                  21    
HELIX  135 AO9 PRO L  104  THR L  116  1                                  13    
HELIX  136 AP1 GLN L  117  GLN L  121  5                                   5    
HELIX  137 AP2 SER L  165  MET L  176  1                                  12    
HELIX  138 AP3 ASN L  183  ARG L  196  1                                  14    
HELIX  139 AP4 ASP L  225  ASP L  228  5                                   4    
HELIX  140 AP5 VAL L  229  GLU L  234  1                                   6    
HELIX  141 AP6 VAL M   20  ASN M   32  1                                  13    
HELIX  142 AP7 LEU M   80  PHE M  102  1                                  23    
HELIX  143 AP8 PRO M  107  TYR M  125  1                                  19    
HELIX  144 AP9 GLN M  170  LEU M  179  5                                  10    
HELIX  145 AQ1 ASP M  188  VAL M  200  1                                  13    
HELIX  146 AQ2 LEU M  219  ASN M  221  5                                   3    
HELIX  147 AQ3 GLU M  233  SER M  242  1                                  10    
HELIX  148 AQ4 SER N   48  ASN N   71  1                                  24    
HELIX  149 AQ5 LEU N   75  TYR N   90  1                                  16    
HELIX  150 AQ6 GLY N  129  TYR N  134  5                                   6    
HELIX  151 AQ7 ILE N  135  ASP N  140  1                                   6    
HELIX  152 AQ8 THR N  148  ASP N  167  1                                  20    
HELIX  153 AQ9 THR O   48  SER O   67  1                                  20    
HELIX  154 AR1 LEU O   68  THR O   70  5                                   3    
HELIX  155 AR2 VAL O   76  TYR O   90  1                                  15    
HELIX  156 AR3 GLY O  130  PHE O  142  1                                  13    
HELIX  157 AR4 GLU O  147  ASP O  166  1                                  20    
HELIX  158 AR5 LEU P   56  GLU P   78  1                                  23    
HELIX  159 AR6 LYS P   83  TYR P   96  1                                  14    
HELIX  160 AR7 ALA P  143  TRP P  154  1                                  12    
HELIX  161 AR8 ASP P  159  ASP P  176  1                                  18    
HELIX  162 AR9 GLU Q   49  GLY Q   72  1                                  24    
HELIX  163 AS1 SER Q   76  ARG Q   93  1                                  18    
HELIX  164 AS2 GLY Q  135  TYR Q  146  1                                  12    
HELIX  165 AS3 GLU Q  154  GLN Q  168  1                                  15    
HELIX  166 AS4 GLY R   48  ASN R   70  1                                  23    
HELIX  167 AS5 SER R   75  TYR R   90  1                                  16    
HELIX  168 AS6 SER R  132  TYR R  143  1                                  12    
HELIX  169 AS7 GLU R  148  ASP R  167  1                                  20    
HELIX  170 AS8 VAL R  192  GLY R  201  1                                  10    
HELIX  171 AS9 PHE S   57  HIS S   77  1                                  21    
HELIX  172 AT1 THR S   84  ARG S   99  1                                  16    
HELIX  173 AT2 GLY S  139  MET S  144  5                                   6    
HELIX  174 AT3 LEU S  145  VAL S  153  1                                   9    
HELIX  175 AT4 ARG S  170  ASP S  186  1                                  17    
HELIX  176 AT5 ASP T   56  LEU T   76  1                                  21    
HELIX  177 AT6 SER T   84  SER T  101  1                                  18    
HELIX  178 AT7 GLY T  140  LEU T  145  1                                   6    
HELIX  179 AT8 LEU T  145  GLN T  157  1                                  13    
HELIX  180 AT9 SER T  161  ASP T  180  1                                  20    
HELIX  181 AU1 TRP T  209  HIS T  213  5                                   5    
HELIX  182 AU2 GLY U    7  GLU U   14  5                                   8    
HELIX  183 AU3 PRO U   17  TRP U   35  1                                  19    
HELIX  184 AU4 ALA U   36  GLU U   40  5                                   5    
HELIX  185 AU5 SER U   41  GLU U   50  1                                  10    
HELIX  186 AU6 SER U   56  GLY U   72  1                                  17    
HELIX  187 AU7 PHE U   74  GLY U   83  1                                  10    
HELIX  188 AU8 GLY U   85  VAL U   90  1                                   6    
HELIX  189 AU9 GLU U   95  ALA U  116  1                                  22    
HELIX  190 AV1 ASP U  127  ASP U  144  1                                  18    
HELIX  191 AV2 ILE U  151  ARG U  158  1                                   8    
HELIX  192 AV3 ARG U  159  LEU U  168  1                                  10    
HELIX  193 AV4 GLY U  175  MET U  188  1                                  14    
HELIX  194 AV5 PHE U  193  LEU U  208  1                                  16    
HELIX  195 AV6 PHE U  213  ASP U  224  1                                  12    
HELIX  196 AV7 ASP U  225  ASP U  240  1                                  16    
HELIX  197 AV8 ASN U  241  SER U  255  1                                  15    
HELIX  198 AV9 SER U  257  THR U  270  1                                  14    
HELIX  199 AW1 GLN U  321  SER U  330  1                                  10    
HELIX  200 AW2 GLY U  331  ASN U  346  1                                  16    
HELIX  201 AW3 LEU U  350  THR U  356  1                                   7    
HELIX  202 AW4 VAL U  364  HIS U  377  1                                  14    
HELIX  203 AW5 GLN U  384  ASN U  389  1                                   6    
HELIX  204 AW6 ASN U  389  ALA U  396  1                                   8    
HELIX  205 AW7 ALA U  400  HIS U  412  1                                  13    
HELIX  206 AW8 LEU U  420  TYR U  426  5                                   7    
HELIX  207 AW9 LEU U  427  SER U  432  1                                   6    
HELIX  208 AX1 GLY U  441  HIS U  450  1                                  10    
HELIX  209 AX2 ASP U  456  LYS U  466  1                                  11    
HELIX  210 AX3 ASP U  471  ALA U  485  1                                  15    
HELIX  211 AX4 GLN U  491  TYR U  502  1                                  12    
HELIX  212 AX5 ASP U  505  MET U  520  1                                  16    
HELIX  213 AX6 ASN U  525  VAL U  533  1                                   9    
HELIX  214 AX7 HIS U  541  MET U  556  1                                  16    
HELIX  215 AX8 ALA U  563  ASP U  573  1                                  11    
HELIX  216 AX9 ASP U  575  CYS U  591  1                                  17    
HELIX  217 AY1 ASN U  595  SER U  608  1                                  14    
HELIX  218 AY2 ASN U  611  LEU U  626  1                                  16    
HELIX  219 AY3 THR U  629  GLU U  631  5                                   3    
HELIX  220 AY4 GLN U  632  VAL U  637  1                                   6    
HELIX  221 AY5 SER U  638  SER U  643  5                                   6    
HELIX  222 AY6 ASN U  645  CYS U  660  1                                  16    
HELIX  223 AY7 ASN U  665  LEU U  672  1                                   8    
HELIX  224 AY8 PRO U  674  ASP U  678  5                                   5    
HELIX  225 AY9 VAL U  680  MET U  695  1                                  16    
HELIX  226 AZ1 PRO U  704  ASP U  719  1                                  16    
HELIX  227 AZ2 ASP U  723  ALA U  739  1                                  17    
HELIX  228 AZ3 GLY U  740  ASN U  743  5                                   4    
HELIX  229 AZ4 HIS U  756  PHE U  766  1                                  11    
HELIX  230 AZ5 PHE U  773  PHE U  778  1                                   6    
HELIX  231 AZ6 LEU U  779  TYR U  783  5                                   5    
HELIX  232 AZ7 PRO V   19  GLN V   24  1                                   6    
HELIX  233 AZ8 ASP V   34  GLY V   53  1                                  20    
HELIX  234 AZ9 ALA V   60  ASP V   74  1                                  15    
HELIX  235 BA1 GLY V   88  LEU V   95  1                                   8    
HELIX  236 BA2 SER V  103  TYR V  114  1                                  12    
HELIX  237 BA3 TYR V  114  PHE V  120  1                                   7    
HELIX  238 BA4 THR V  127  ASP V  129  5                                   3    
HELIX  239 BA5 PHE V  130  THR V  141  1                                  12    
HELIX  240 BA6 PHE V  147  ALA V  155  1                                   9    
HELIX  241 BA7 LEU V  160  TYR V  166  5                                   7    
HELIX  242 BA8 VAL V  171  MET V  192  1                                  22    
HELIX  243 BA9 GLN V  198  ASP V  222  1                                  25    
HELIX  244 BB1 ASP V  225  ALA V  238  1                                  14    
HELIX  245 BB2 ASP V  245  TYR V  261  1                                  17    
HELIX  246 BB3 GLU V  268  LYS V  273  1                                   6    
HELIX  247 BB4 ASN V  282  GLN V  299  1                                  18    
HELIX  248 BB5 TYR V  302  LYS V  315  1                                  14    
HELIX  249 BB6 GLY V  323  LEU V  331  1                                   9    
HELIX  250 BB7 ILE V  333  GLY V  340  1                                   8    
HELIX  251 BB8 ASP V  344  ARG V  349  5                                   6    
HELIX  252 BB9 GLN V  350  ARG V  368  1                                  19    
HELIX  253 BC1 ASN V  371  GLY V  390  1                                  20    
HELIX  254 BC2 THR V  391  TYR V  414  1                                  24    
HELIX  255 BC3 SER V  418  LEU V  426  1                                   9    
HELIX  256 BC4 SER V  430  ASP V  444  1                                  15    
HELIX  257 BC5 ARG V  470  PHE V  496  1                                  27    
HELIX  258 BC6 ALA W    2  VAL W   18  1                                  17    
HELIX  259 BC7 SER W   21  ARG W   27  1                                   7    
HELIX  260 BC8 ARG W   27  GLY W   38  1                                  12    
HELIX  261 BC9 GLU W   42  ARG W   65  1                                  24    
HELIX  262 BD1 ALA W   69  LEU W   83  1                                  15    
HELIX  263 BD2 ARG W   94  ILE W  115  1                                  22    
HELIX  264 BD3 THR W  116  GLY W  134  1                                  19    
HELIX  265 BD4 GLU W  139  ASN W  156  1                                  18    
HELIX  266 BD5 ASP W  158  GLN W  170  1                                  13    
HELIX  267 BD6 GLN W  170  SER W  176  1                                   7    
HELIX  268 BD7 LYS W  180  LEU W  187  1                                   8    
HELIX  269 BD8 LEU W  187  LYS W  197  1                                  11    
HELIX  270 BD9 ASP W  198  LYS W  208  1                                  11    
HELIX  271 BE1 LEU W  222  GLU W  237  1                                  16    
HELIX  272 BE2 SER W  242  TYR W  247  1                                   6    
HELIX  273 BE3 TYR W  251  GLN W  257  1                                   7    
HELIX  274 BE4 SER W  260  LEU W  272  1                                  13    
HELIX  275 BE5 LEU W  272  ALA W  277  1                                   6    
HELIX  276 BE6 ASP W  280  ILE W  290  1                                  11    
HELIX  277 BE7 ILE W  299  THR W  310  1                                  12    
HELIX  278 BE8 ARG W  316  LYS W  330  1                                  15    
HELIX  279 BE9 GLU W  334  VAL W  340  1                                   7    
HELIX  280 BF1 SER W  343  TYR W  370  1                                  28    
HELIX  281 BF2 MET W  375  ASP W  383  1                                   9    
HELIX  282 BF3 SER W  385  ASN W  399  1                                  15    
HELIX  283 BF4 ASN W  423  ASN W  440  1                                  18    
HELIX  284 BF5 ASN W  440  GLN W  456  1                                  17    
HELIX  285 BF6 LEU X  183  ASN X  198  1                                  16    
HELIX  286 BF7 LEU X  206  GLU X  221  1                                  16    
HELIX  287 BF8 ASP X  224  TYR X  239  1                                  16    
HELIX  288 BF9 ASP X  243  THR X  249  1                                   7    
HELIX  289 BG1 THR X  249  ASN X  262  1                                  14    
HELIX  290 BG2 ASP X  266  SER X  272  1                                   7    
HELIX  291 BG3 LEU X  275  TYR X  279  5                                   5    
HELIX  292 BG4 GLY X  281  ARG X  297  1                                  17    
HELIX  293 BG5 SER X  298  TYR X  309  1                                  12    
HELIX  294 BG6 TYR X  309  ASP X  315  1                                   7    
HELIX  295 BG7 ILE X  318  GLU X  340  1                                  23    
HELIX  296 BG8 ILE X  347  SER X  351  1                                   5    
HELIX  297 BG9 ASP X  360  ASP X  371  1                                  12    
HELIX  298 BH1 THR X  396  THR X  422  1                                  27    
HELIX  299 BH2 LYS Y   13  LEU Y   28  1                                  16    
HELIX  300 BH3 GLY Y   33  ARG Y   46  1                                  14    
HELIX  301 BH4 MET Y   50  SER Y   60  1                                  11    
HELIX  302 BH5 ASP Y   66  GLU Y   92  1                                  27    
HELIX  303 BH6 GLU Y  109  GLY Y  115  1                                   7    
HELIX  304 BH7 LYS Y  117  THR Y  127  1                                  11    
HELIX  305 BH8 ALA Y  133  TYR Y  151  1                                  19    
HELIX  306 BH9 ASN Y  154  GLU Y  169  1                                  16    
HELIX  307 BI1 TRP Y  174  ILE Y  191  1                                  18    
HELIX  308 BI2 PHE Y  194  PHE Y  201  1                                   8    
HELIX  309 BI3 LEU Y  202  PHE Y  208  5                                   7    
HELIX  310 BI4 ASP Y  215  SER Y  227  1                                  13    
HELIX  311 BI5 GLU Y  232  LYS Y  242  1                                  11    
HELIX  312 BI6 ALA Y  244  SER Y  252  1                                   9    
HELIX  313 BI7 LEU Y  253  CYS Y  266  1                                  14    
HELIX  314 BI8 VAL Y  270  ASP Y  285  1                                  16    
HELIX  315 BI9 HIS Y  291  GLU Y  309  1                                  19    
HELIX  316 BJ1 THR Y  315  GLY Y  324  1                                  10    
HELIX  317 BJ2 GLU Y  328  ALA Y  340  1                                  13    
HELIX  318 BJ3 ASN Y  363  TYR Y  366  5                                   4    
HELIX  319 BJ4 GLN Y  367  VAL Y  386  1                                  20    
HELIX  320 BJ5 HIS Z   12  GLY Z   30  1                                  19    
HELIX  321 BJ6 ASP Z   71  ASN Z   86  1                                  16    
HELIX  322 BJ7 HIS Z  102  ASN Z  104  5                                   3    
HELIX  323 BJ8 ASP Z  105  LYS Z  113  1                                   9    
HELIX  324 BJ9 GLU Z  168  ARG Z  177  1                                  10    
HELIX  325 BK1 THR Z  186  THR Z  217  1                                  32    
HELIX  326 BK2 GLN Z  225  PHE Z  234  1                                  10    
HELIX  327 BK3 ASN Z  235  LEU Z  237  5                                   3    
HELIX  328 BK4 ALA Z  248  GLY Z  290  1                                  43    
HELIX  329 BK5 PRO a    5  SER a   11  1                                   7    
HELIX  330 BK6 GLY a   17  LYS a   31  1                                  15    
HELIX  331 BK7 LEU a   33  ASP a   47  1                                  15    
HELIX  332 BK8 GLN a   52  HIS a   69  1                                  18    
HELIX  333 BK9 ASN a   72  THR a   88  1                                  17    
HELIX  334 BL1 ASP a   89  VAL a  104  1                                  16    
HELIX  335 BL2 ALA a  110  LYS a  122  1                                  13    
HELIX  336 BL3 LEU a  123  ILE a  125  5                                   3    
HELIX  337 BL4 VAL a  130  ASN a  143  1                                  14    
HELIX  338 BL5 SER a  150  GLN a  164  1                                  15    
HELIX  339 BL6 ASN a  168  GLY a  181  1                                  14    
HELIX  340 BL7 PRO a  189  GLU a  195  1                                   7    
HELIX  341 BL8 GLU a  195  GLY a  207  1                                  13    
HELIX  342 BL9 HIS a  219  ASP a  229  1                                  11    
HELIX  343 BM1 ARG a  230  SER a  242  1                                  13    
HELIX  344 BM2 GLU a  246  GLN a  257  1                                  12    
HELIX  345 BM3 ASN a  264  ARG a  284  1                                  21    
HELIX  346 BM4 THR a  292  ALA a  300  1                                   9    
HELIX  347 BM5 THR a  303  ASN a  305  5                                   3    
HELIX  348 BM6 GLU a  306  GLY a  318  1                                  13    
HELIX  349 BM7 ASP a  342  LEU a  353  1                                  12    
HELIX  350 BM8 LEU a  353  HIS a  372  1                                  20    
HELIX  351 BM9 SER b   13  ARG b   17  5                                   5    
HELIX  352 BN1 THR b   24  ASN b   44  1                                  21    
HELIX  353 BN2 THR b   68  LEU b   75  1                                   8    
HELIX  354 BN3 PHE b   86  GLY b   89  5                                   4    
HELIX  355 BN4 ILE b   90  HIS b   99  1                                  10    
HELIX  356 BN5 ASN b  120  LYS b  135  1                                  16    
HELIX  357 BN6 GLU b  151  THR b  159  1                                   9    
HELIX  358 BN7 ALA b  180  ILE b  184  1                                   5    
HELIX  359 BN8 ILE b  184  ALA b  190  1                                   7    
HELIX  360 BN9 SER c   34  VAL c   49  1                                  16    
HELIX  361 BO1 SER c   83  VAL c   87  5                                   5    
HELIX  362 BO2 ASP c   88  THR c  102  1                                  15    
HELIX  363 BO3 SER c  123  THR c  129  1                                   7    
HELIX  364 BO4 THR c  129  SER c  137  1                                   9    
HELIX  365 BO5 ASN c  164  LEU c  170  5                                   7    
HELIX  366 BO6 THR c  178  HIS c  183  1                                   6    
HELIX  367 BO7 ALA c  191  LEU c  196  1                                   6    
HELIX  368 BO8 ASN c  210  MET c  226  1                                  17    
HELIX  369 BO9 VAL c  245  LYS c  257  1                                  13    
HELIX  370 BP1 LYS c  257  ALA c  271  1                                  15    
HELIX  371 BP2 GLU c  286  MET c  303  1                                  18    
HELIX  372 BP3 MET c  303  VAL c  308  1                                   6    
HELIX  373 BP4 LYS d    6  LYS d   12  1                                   7    
HELIX  374 BP5 ASN d   15  LEU d   33  1                                  19    
HELIX  375 BP6 THR d   41  THR d   44  5                                   4    
HELIX  376 BP7 LYS d   45  LYS d   66  1                                  22    
HELIX  377 BP8 ASP d   67  ASP d   84  1                                  18    
HELIX  378 BP9 TYR d   94  GLN d  109  1                                  16    
HELIX  379 BQ1 VAL d  112  LEU d  119  1                                   8    
HELIX  380 BQ2 GLU d  120  LEU d  122  5                                   3    
HELIX  381 BQ3 ASN d  130  MET d  144  1                                  15    
HELIX  382 BQ4 TYR d  148  LYS d  155  1                                   8    
HELIX  383 BQ5 TYR d  163  ASP d  176  1                                  14    
HELIX  384 BQ6 ASP d  176  GLU d  183  1                                   8    
HELIX  385 BQ7 PHE d  191  PHE d  199  1                                   9    
HELIX  386 BQ8 PRO d  203  ARG d  213  1                                  11    
HELIX  387 BQ9 PRO d  238  ILE d  256  1                                  19    
HELIX  388 BR1 ASP e   41  GLN e   55  1                                  15    
HELIX  389 BR2 LEU e   60  SER e   70  1                                  11    
HELIX  390 BR3 ASP f   15  VAL f   20  1                                   6    
HELIX  391 BR4 GLU f   23  THR f   27  5                                   5    
HELIX  392 BR5 LEU f   28  GLU f   31  5                                   4    
HELIX  393 BR6 ILE f   32  ALA f   38  1                                   7    
HELIX  394 BR7 ASP f   47  LEU f   58  1                                  12    
HELIX  395 BR8 ILE f   62  LEU f   72  1                                  11    
HELIX  396 BR9 VAL f   81  ARG f   98  1                                  18    
HELIX  397 BS1 ASN f  114  VAL f  129  1                                  16    
HELIX  398 BS2 GLN f  134  GLY f  140  1                                   7    
HELIX  399 BS3 ARG f  141  SER f  149  1                                   9    
HELIX  400 BS4 GLU f  153  ASP f  157  5                                   5    
HELIX  401 BS5 ASN f  164  ILE f  180  1                                  17    
HELIX  402 BS6 VAL f  185  TYR f  190  5                                   6    
HELIX  403 BS7 ASN f  196  GLN f  205  1                                  10    
HELIX  404 BS8 ASN f  212  SER f  216  5                                   5    
HELIX  405 BS9 VAL f  218  ALA f  224  1                                   7    
HELIX  406 BT1 GLN f  228  LYS f  238  1                                  11    
HELIX  407 BT2 LYS f  244  LEU f  249  5                                   6    
HELIX  408 BT3 ALA f  252  GLY f  265  1                                  14    
HELIX  409 BT4 ILE f  270  ASP f  279  1                                  10    
HELIX  410 BT5 ALA f  288  ARG f  297  1                                  10    
HELIX  411 BT6 CYS f  300  LEU f  312  1                                  13    
HELIX  412 BT7 MET f  318  GLY f  332  1                                  15    
HELIX  413 BT8 ASP f  337  LEU f  342  1                                   6    
HELIX  414 BT9 LEU f  342  ASP f  348  1                                   7    
HELIX  415 BU1 ALA f  356  ILE f  366  1                                  11    
HELIX  416 BU2 GLY f  373  MET f  384  1                                  12    
HELIX  417 BU3 TRP f  398  LEU f  403  5                                   6    
HELIX  418 BU4 ILE f  414  ALA f  420  1                                   7    
HELIX  419 BU5 LEU f  421  SER f  425  5                                   5    
HELIX  420 BU6 ARG f  429  ALA f  440  1                                  12    
HELIX  421 BU7 VAL f  447  GLU f  459  1                                  13    
HELIX  422 BU8 LYS f  464  ASP f  477  1                                  14    
HELIX  423 BU9 LYS f  481  MET f  487  1                                   7    
HELIX  424 BV1 ALA f  494  GLU f  505  1                                  12    
HELIX  425 BV2 ALA f  512  GLY f  523  1                                  12    
HELIX  426 BV3 ALA f  530  SER f  541  5                                  12    
HELIX  427 BV4 ASN f  542  HIS f  556  1                                  15    
HELIX  428 BV5 ASP f  559  GLY f  571  1                                  13    
HELIX  429 BV6 ASN f  579  LEU f  586  1                                   8    
HELIX  430 BV7 PRO f  597  GLY f  608  1                                  12    
HELIX  431 BV8 LEU f  609  HIS f  611  5                                   3    
HELIX  432 BV9 TYR f  622  ALA f  633  1                                  12    
HELIX  433 BW1 VAL f  640  ASP f  646  1                                   7    
HELIX  434 BW2 MET f  670  GLU f  677  1                                   8    
HELIX  435 BW3 ARG f  686  ASP f  692  1                                   7    
SHEET    1 AA1 3 LYS A 100  ASP A 105  0                                        
SHEET    2 AA1 3 TYR A 111  VAL A 115 -1  O  ASN A 114   N  ILE A 101           
SHEET    3 AA1 3 LYS A 120  VAL A 123 -1  O  PHE A 121   N  ILE A 113           
SHEET    1 AA2 2 VAL A 140  VAL A 142  0                                        
SHEET    2 AA2 2 ILE A 149  PRO A 152 -1  O  ILE A 151   N  GLY A 141           
SHEET    1 AA3 2 LEU A 213  PHE A 215  0                                        
SHEET    2 AA3 2 LYS A 340  GLU A 342  1  O  ILE A 341   N  LEU A 213           
SHEET    1 AA4 2 ILE A 238  ILE A 241  0                                        
SHEET    2 AA4 2 ILE A 272  ASP A 275  1  O  PHE A 273   N  VAL A 240           
SHEET    1 AA5 4 LEU B 151  ASN B 153  0                                        
SHEET    2 AA5 4 PRO B 106  VAL B 109 -1  N  SER B 108   O  LEU B 152           
SHEET    3 AA5 4 LYS C  94  VAL C  97 -1  O  LYS C  94   N  VAL B 109           
SHEET    4 AA5 4 VAL C  85  LYS C  88 -1  N  VAL C  87   O  PHE C  95           
SHEET    1 AA6 3 THR B 111  ILE B 115  0                                        
SHEET    2 AA6 3 HIS B 120  SER B 124 -1  O  SER B 124   N  THR B 111           
SHEET    3 AA6 3 TYR B 132  SER B 134 -1  O  VAL B 133   N  ALA B 121           
SHEET    1 AA7 4 VAL B 222  ILE B 223  0                                        
SHEET    2 AA7 4 VAL B 327  MET B 329  1  O  VAL B 327   N  VAL B 222           
SHEET    3 AA7 4 VAL B 282  ASP B 285  1  N  ILE B 284   O  ILE B 328           
SHEET    4 AA7 4 LEU B 248  VAL B 251  1  N  VAL B 250   O  PHE B 283           
SHEET    1 AA8 2 SER C  71  GLU C  75  0                                        
SHEET    2 AA8 2 ARG C 113  ARG C 117 -1  O  LEU C 116   N  TYR C  72           
SHEET    1 AA9 3 ILE C 292  THR C 295  0                                        
SHEET    2 AA9 3 GLY C 185  TYR C 189  1  N  LEU C 188   O  THR C 295           
SHEET    3 AA9 3 ASP C 312  LYS C 314  1  O  ARG C 313   N  GLY C 185           
SHEET    1 AB1 2 THR C 210  PHE C 211  0                                        
SHEET    2 AB1 2 SER C 244  ILE C 245  1  O  ILE C 245   N  THR C 210           
SHEET    1 AB2 4 ASN D 110  ARG D 114  0                                        
SHEET    2 AB2 4 THR D 100  SER D 105 -1  N  VAL D 103   O  TYR D 111           
SHEET    3 AB2 4 LEU D  87  ASP D  97 -1  N  GLN D  91   O  GLY D 104           
SHEET    4 AB2 4 SER D 129  HIS D 133 -1  O  LEU D 132   N  VAL D  88           
SHEET    1 AB3 5 ALA D 226  VAL D 231  0                                        
SHEET    2 AB3 5 ALA D 260  ASP D 265  1  O  PHE D 263   N  ILE D 228           
SHEET    3 AB3 5 VAL D 307  ALA D 310  1  O  ILE D 308   N  ILE D 262           
SHEET    4 AB3 5 GLY D 201  TYR D 205  1  N  MET D 204   O  MET D 309           
SHEET    5 AB3 5 LYS D 330  GLU D 332  1  O  ILE D 331   N  LEU D 203           
SHEET    1 AB4 4 ARG E  78  VAL E  81  0                                        
SHEET    2 AB4 4 PHE E  69  ALA E  73 -1  N  VAL E  71   O  TYR E  79           
SHEET    3 AB4 4 GLN E  55  GLN E  63 -1  N  GLU E  59   O  LYS E  72           
SHEET    4 AB4 4 ARG E  97  LEU E 100 -1  O  LEU E 100   N  ILE E  56           
SHEET    1 AB5 5 ARG E  78  VAL E  81  0                                        
SHEET    2 AB5 5 PHE E  69  ALA E  73 -1  N  VAL E  71   O  TYR E  79           
SHEET    3 AB5 5 GLN E  55  GLN E  63 -1  N  GLU E  59   O  LYS E  72           
SHEET    4 AB5 5 THR F 131  PRO F 135 -1  O  THR F 131   N  VAL E  57           
SHEET    5 AB5 5 CYS F 121  LYS F 125 -1  N  ILE F 124   O  TYR F 132           
SHEET    1 AB6 4 ILE E 229  ILE E 230  0                                        
SHEET    2 AB6 4 LYS E 274  THR E 279  1  O  LYS E 274   N  ILE E 230           
SHEET    3 AB6 4 GLY E 169  TYR E 173  1  N  LEU E 172   O  MET E 277           
SHEET    4 AB6 4 ARG E 297  ILE E 299  1  O  ARG E 297   N  LEU E 171           
SHEET    1 AB7 2 LEU F  89  SER F  91  0                                        
SHEET    2 AB7 2 VAL F 151  VAL F 153 -1  O  VAL F 153   N  LEU F  89           
SHEET    1 AB8 4 ILE F 283  PHE F 284  0                                        
SHEET    2 AB8 4 VAL F 328  THR F 332  1  O  ILE F 329   N  ILE F 283           
SHEET    3 AB8 4 GLY F 222  TYR F 226  1  N  VAL F 223   O  ALA F 330           
SHEET    4 AB8 4 LEU F 348  GLU F 353  1  O  ASP F 349   N  GLY F 222           
SHEET    1 AB9 3 VAL G  40  ARG G  43  0                                        
SHEET    2 AB9 3 CYS G  47  THR G  52 -1  O  VAL G  49   N  VAL G  42           
SHEET    3 AB9 3 GLU G 216  THR G 221 -1  O  GLY G 218   N  ILE G  50           
SHEET    1 AC1 4 LEU G  69  PHE G  70  0                                        
SHEET    2 AC1 4 CYS G  78  MET G  80 -1  O  CYS G  78   N  PHE G  70           
SHEET    3 AC1 4 MET G 138  ILE G 143 -1  O  ILE G 139   N  VAL G  79           
SHEET    4 AC1 4 PRO G 149  CYS G 154 -1  O  TYR G 152   N  LEU G 140           
SHEET    1 AC2 5 ALA H 160  MET H 163  0                                        
SHEET    2 AC2 5 SER H  35  ALA H  40 -1  N  GLY H  37   O  THR H 161           
SHEET    3 AC2 5 GLY H  43  GLU H  49 -1  O  ALA H  47   N  VAL H  36           
SHEET    4 AC2 5 ILE H 208  ASN H 214 -1  O  CYS H 213   N  VAL H  44           
SHEET    5 AC2 5 GLY H 217  ARG H 220 -1  O  GLY H 217   N  ASN H 214           
SHEET    1 AC3 4 LEU H  74  VAL H  75  0                                        
SHEET    2 AC3 4 LEU H 135  ASN H 140 -1  O  LEU H 135   N  VAL H  75           
SHEET    3 AC3 4 ARG H 143  GLN H 148 -1  O  PHE H 147   N  ILE H 136           
SHEET    4 AC3 4 PHE H 156  ALA H 157 -1  O  PHE H 156   N  GLN H 148           
SHEET    1 AC4 5 THR I 162  ILE I 164  0                                        
SHEET    2 AC4 5 THR I  33  GLY I  36 -1  N  CYS I  34   O  ILE I 164           
SHEET    3 AC4 5 VAL I  43  GLU I  48 -1  O  GLU I  48   N  THR I  33           
SHEET    4 AC4 5 VAL I 211  LEU I 216 -1  O  LEU I 216   N  VAL I  43           
SHEET    5 AC4 5 ILE I 225  VAL I 227 -1  O  ARG I 226   N  THR I 215           
SHEET    1 AC5 3 VAL I  76  ALA I  77  0                                        
SHEET    2 AC5 3 SER I 133  ASP I 140 -1  O  SER I 133   N  ALA I  77           
SHEET    3 AC5 3 GLY I 144  GLN I 149 -1  O  TYR I 148   N  TYR I 136           
SHEET    1 AC6 4 ASN J 159  ALA J 160  0                                        
SHEET    2 AC6 4 ALA J  32  GLY J  34 -1  N  GLY J  34   O  ASN J 159           
SHEET    3 AC6 4 ILE J  40  VAL J  45 -1  O  GLY J  44   N  VAL J  33           
SHEET    4 AC6 4 VAL J 210  ARG J 212 -1  O  MET J 211   N  VAL J  41           
SHEET    1 AC7 4 ILE J  62  ALA J  64  0                                        
SHEET    2 AC7 4 VAL J  69  ALA J  74 -1  O  MET J  71   N  CYS J  63           
SHEET    3 AC7 4 SER J 130  PHE J 136 -1  O  VAL J 134   N  CYS J  70           
SHEET    4 AC7 4 PRO J 142  LEU J 144 -1  O  ARG J 143   N  GLY J 135           
SHEET    1 AC8 3 ALA K  37  GLN K  41  0                                        
SHEET    2 AC8 3 VAL K  46  VAL K  50 -1  O  ALA K  49   N  ILE K  38           
SHEET    3 AC8 3 LEU K 217  VAL K 220 -1  O  ALA K 218   N  LEU K  48           
SHEET    1 AC9 5 ILE K  67  ASP K  71  0                                        
SHEET    2 AC9 5 ILE K  74  ALA K  77 -1  O  ILE K  74   N  ASP K  71           
SHEET    3 AC9 5 LEU K 141  ASP K 147 -1  O  LEU K 142   N  ALA K  77           
SHEET    4 AC9 5 GLY K 150  MET K 156 -1  O  PHE K 154   N  PHE K 143           
SHEET    5 AC9 5 PHE K 162  VAL K 163 -1  O  VAL K 163   N  HIS K 155           
SHEET    1 AD1 5 ALA L 158  ILE L 161  0                                        
SHEET    2 AD1 5 THR L  35  LYS L  39 -1  N  THR L  35   O  ILE L 161           
SHEET    3 AD1 5 ALA L  44  LEU L  49 -1  O  VAL L  47   N  VAL L  36           
SHEET    4 AD1 5 VAL L 210  VAL L 215 -1  O  SER L 211   N  ALA L  48           
SHEET    5 AD1 5 THR L 222  TYR L 224 -1  O  TYR L 224   N  ILE L 212           
SHEET    1 AD2 4 LEU L  64  HIS L  65  0                                        
SHEET    2 AD2 4 GLY L  71  ILE L  72 -1  O  ILE L  72   N  LEU L  64           
SHEET    3 AD2 4 ILE L 134  ASP L 138 -1  O  ALA L 135   N  GLY L  71           
SHEET    4 AD2 4 GLY L 141  ILE L 144 -1  O  GLY L 141   N  ASP L 138           
SHEET    1 AD3 5 GLY M 162  ILE M 165  0                                        
SHEET    2 AD3 5 ALA M  36  ARG M  40 -1  N  GLY M  38   O  CYS M 163           
SHEET    3 AD3 5 GLY M  44  VAL M  53 -1  O  VAL M  46   N  ILE M  39           
SHEET    4 AD3 5 ALA M 208  GLY M 217 -1  O  GLU M 210   N  LYS M  51           
SHEET    5 AD3 5 HIS M 224  ILE M 226 -1  O  GLU M 225   N  TRP M 215           
SHEET    1 AD4 5 LEU M  66  PHE M  67  0                                        
SHEET    2 AD4 5 VAL M  73  ALA M  76 -1  O  MET M  75   N  PHE M  67           
SHEET    3 AD4 5 MET M 136  SER M 139 -1  O  MET M 136   N  ALA M  76           
SHEET    4 AD4 5 GLN M 147  ILE M 151 -1  O  TYR M 149   N  LEU M 137           
SHEET    5 AD4 5 SER M 157  TYR M 158 -1  O  TYR M 158   N  MET M 150           
SHEET    1 AD5 5 PHE N 125  ILE N 127  0                                        
SHEET    2 AD5 5 ILE N   3  PHE N   8 -1  N  ALA N   5   O  ALA N 126           
SHEET    3 AD5 5 GLY N  11  ALA N  16 -1  O  VAL N  13   N  VAL N   6           
SHEET    4 AD5 5 ILE N 174  ALA N 180 -1  O  ALA N 177   N  LEU N  14           
SHEET    5 AD5 5 GLY N 183  LEU N 189 -1  O  GLU N 185   N  ALA N 178           
SHEET    1 AD6 2 THR N  20  THR N  22  0                                        
SHEET    2 AD6 2 TYR N  25  ASN N  28 -1  O  ASN N  28   N  THR N  20           
SHEET    1 AD7 4 ILE N  41  CYS N  44  0                                        
SHEET    2 AD7 4 ILE N  99  ASP N 104 -1  O  ALA N 101   N  PHE N  42           
SHEET    3 AD7 4 GLY N 108  SER N 113 -1  O  TYR N 112   N  ILE N 100           
SHEET    4 AD7 4 VAL N 121  ARG N 122 -1  O  VAL N 121   N  SER N 113           
SHEET    1 AD8 5 TYR O 124  GLY O 128  0                                        
SHEET    2 AD8 5 THR O   2  VAL O   7 -1  N  ILE O   3   O  MET O 127           
SHEET    3 AD8 5 GLY O  11  ALA O  16 -1  O  VAL O  13   N  VAL O   6           
SHEET    4 AD8 5 ILE O 173  SER O 179 -1  O  ILE O 178   N  ILE O  12           
SHEET    5 AD8 5 LEU O 183  THR O 190 -1  O  TYR O 189   N  ILE O 173           
SHEET    1 AD9 2 ALA O  20  GLU O  22  0                                        
SHEET    2 AD9 2 VAL O  25  ASP O  28 -1  O  ASP O  28   N  ALA O  20           
SHEET    1 AE1 5 ILE O  34  PHE O  36  0                                        
SHEET    2 AE1 5 ILE O  41  CYS O  44 -1  O  CYS O  43   N  HIS O  35           
SHEET    3 AE1 5 LEU O  98  ASP O 104 -1  O  VAL O  99   N  CYS O  44           
SHEET    4 AE1 5 GLY O 107  ILE O 113 -1  O  TYR O 111   N  LEU O 100           
SHEET    5 AE1 5 THR O 119  LYS O 121 -1  O  ASP O 120   N  SER O 112           
SHEET    1 AE2 6 VAL O 211  PRO O 218  0                                        
SHEET    2 AE2 6 LYS P 194  LEU P 200 -1  O  ILE P 195   N  THR O 217           
SHEET    3 AE2 6 VAL P 185  ILE P 190 -1  N  VAL P 187   O  ARG P 198           
SHEET    4 AE2 6 VAL P  20  ASP P  25 -1  N  ILE P  22   O  HIS P 188           
SHEET    5 AE2 6 ALA P  10  LYS P  15 -1  N  MET P  14   O  ALA P  21           
SHEET    6 AE2 6 PHE P 136  GLY P 140 -1  O  SER P 139   N  VAL P  11           
SHEET    1 AE3 2 PHE P  28  ILE P  30  0                                        
SHEET    2 AE3 2 GLN P  33  THR P  36 -1  O  VAL P  35   N  PHE P  28           
SHEET    1 AE4 5 PHE P  43  PRO P  44  0                                        
SHEET    2 AE4 5 LEU P  49  GLY P  52 -1  O  ILE P  51   N  PHE P  43           
SHEET    3 AE4 5 VAL P 108  LEU P 112 -1  O  VAL P 108   N  GLY P  52           
SHEET    4 AE4 5 PRO P 119  LEU P 124 -1  O  PHE P 120   N  GLY P 111           
SHEET    5 AE4 5 PRO P 130  VAL P 132 -1  O  MET P 131   N  SER P 123           
SHEET    1 AE5 3 VAL Q  13  ASP Q  18  0                                        
SHEET    2 AE5 3 PHE Q 178  ASP Q 184 -1  O  SER Q 179   N  SER Q  17           
SHEET    3 AE5 3 GLY Q 187  ASP Q 190 -1  O  HIS Q 189   N  ILE Q 182           
SHEET    1 AE6 3 PHE Q  36  LYS Q  37  0                                        
SHEET    2 AE6 3 ILE Q  42  LEU Q  44 -1  O  LEU Q  44   N  PHE Q  36           
SHEET    3 AE6 3 LEU Q 104  GLY Q 106 -1  O  ALA Q 105   N  LEU Q  43           
SHEET    1 AE7 2 TYR Q 116  TYR Q 117  0                                        
SHEET    2 AE7 2 ALA Q 125  LYS Q 126 -1  O  ALA Q 125   N  TYR Q 117           
SHEET    1 AE8 5 THR R 125  GLY R 129  0                                        
SHEET    2 AE8 5 THR R   2  LYS R   7 -1  N  ALA R   5   O  PHE R 126           
SHEET    3 AE8 5 VAL R  12  ASP R  17 -1  O  ILE R  13   N  PHE R   6           
SHEET    4 AE8 5 ALA R 173  HIS R 178 -1  O  ASN R 175   N  ALA R  16           
SHEET    5 AE8 5 ILE R 185  ASN R 191 -1  O  ASP R 190   N  VAL R 174           
SHEET    1 AE9 2 ALA R  20  ALA R  22  0                                        
SHEET    2 AE9 2 TYR R  25  SER R  28 -1  O  SER R  28   N  ALA R  20           
SHEET    1 AF1 4 LEU R  41  LEU R  42  0                                        
SHEET    2 AF1 4 MET R 100  TRP R 104 -1  O  CYS R 102   N  LEU R  42           
SHEET    3 AF1 4 PRO R 109  VAL R 114 -1  O  TYR R 112   N  ILE R 101           
SHEET    4 AF1 4 ARG R 120  SER R 122 -1  O  ILE R 121   N  TYR R 113           
SHEET    1 AF2 5 PHE S 135  ALA S 137  0                                        
SHEET    2 AF2 5 ILE S  12  ALA S  16 -1  N  ALA S  14   O  LYS S 136           
SHEET    3 AF2 5 ALA S  21  ASP S  26 -1  O  ALA S  24   N  LEU S  13           
SHEET    4 AF2 5 ALA S 192  THR S 199 -1  O  CYS S 196   N  VAL S  23           
SHEET    5 AF2 5 GLY S 202  SER S 209 -1  O  ARG S 204   N  ILE S 197           
SHEET    1 AF3 2 LEU S  29  GLU S  31  0                                        
SHEET    2 AF3 2 SER S  34  THR S  37 -1  O  THR S  37   N  LEU S  29           
SHEET    1 AF4 5 CYS S  43  LYS S  45  0                                        
SHEET    2 AF4 5 THR S  50  GLY S  53 -1  O  ILE S  52   N  TYR S  44           
SHEET    3 AF4 5 ILE S 109  LEU S 113 -1  O  GLY S 111   N  VAL S  51           
SHEET    4 AF4 5 GLY S 119  SER S 123 -1  O  TYR S 122   N  ILE S 110           
SHEET    5 AF4 5 ARG S 132  ASP S 133 -1  O  ASP S 133   N  VAL S 121           
SHEET    1 AF5 5 SER T 136  ALA T 138  0                                        
SHEET    2 AF5 5 LEU T  12  PHE T  16 -1  N  GLY T  13   O  LEU T 137           
SHEET    3 AF5 5 GLY T  19  ASP T  25 -1  O  ALA T  23   N  LEU T  12           
SHEET    4 AF5 5 PHE T 187  THR T 191 -1  O  ALA T 190   N  ILE T  22           
SHEET    5 AF5 5 GLU T 198  LEU T 203 -1  O  GLU T 200   N  ILE T 189           
SHEET    1 AF6 4 ILE T  42  VAL T  45  0                                        
SHEET    2 AF6 4 THR T  49  ALA T  53 -1  O  LEU T  51   N  MET T  43           
SHEET    3 AF6 4 THR T 109  ALA T 116 -1  O  GLY T 113   N  MET T  50           
SHEET    4 AF6 4 GLU T 119  ASP T 126 -1  O  GLY T 123   N  ILE T 112           
SHEET    1 AF7 2 TYR U 900  GLN U 901  0                                        
SHEET    2 AF7 2 LYS U 915  ASP U 916 -1  O  LYS U 915   N  GLN U 901           
SHEET    1 AF8 3 ILE W 373  THR W 374  0                                        
SHEET    2 AF8 3 ILE W 412  PHE W 415 -1  O  ILE W 413   N  ILE W 373           
SHEET    3 AF8 3 ALA W 404  VAL W 406 -1  N  LYS W 405   O  ASN W 414           
SHEET    1 AF9 2 VAL X 345  GLN X 346  0                                        
SHEET    2 AF9 2 VAL X 384  LEU X 385 -1  O  LEU X 385   N  VAL X 345           
SHEET    1 AG1 3 SER Y 313  LEU Y 314  0                                        
SHEET    2 AG1 3 ILE Y 353  GLU Y 355 -1  O  VAL Y 354   N  LEU Y 314           
SHEET    3 AG1 3 LYS Y 346  ASP Y 348 -1  N  LYS Y 346   O  GLU Y 355           
SHEET    1 AG2 6 VAL Z 120  ILE Z 123  0                                        
SHEET    2 AG2 6 ARG Z  90  HIS Z  96  1  N  HIS Z  96   O  VAL Z 122           
SHEET    3 AG2 6 VAL Z  36  TRP Z  43 -1  N  LEU Z  39   O  GLY Z  93           
SHEET    4 AG2 6 LEU Z  48  ALA Z  55 -1  O  ASP Z  49   N  SER Z  42           
SHEET    5 AG2 6 LYS Z   8  VAL Z  11  1  N  LYS Z   8   O  LEU Z  48           
SHEET    6 AG2 6 THR Z 159  ILE Z 162  1  O  GLU Z 161   N  VAL Z  11           
SHEET    1 AG3 2 ASP Z  59  GLU Z  60  0                                        
SHEET    2 AG3 2 TRP Z  68  PHE Z  69 -1  O  PHE Z  69   N  ASP Z  59           
SHEET    1 AG4 2 TYR Z 138  GLU Z 142  0                                        
SHEET    2 AG4 2 LYS Z 153  HIS Z 157 -1  O  GLU Z 156   N  ILE Z 139           
SHEET    1 AG5 2 ILE a 324  ASP a 325  0                                        
SHEET    2 AG5 2 ARG a 330  VAL a 331 -1  O  ARG a 330   N  ASP a 325           
SHEET    1 AG6 4 LEU b  51  THR b  53  0                                        
SHEET    2 AG6 4 GLU b   4  VAL b  10  1  N  VAL b  10   O  ILE b  52           
SHEET    3 AG6 4 LYS b 106  VAL b 113  1  O  LYS b 106   N  SER b   5           
SHEET    4 AG6 4 ASN b 137  ASN b 142  1  O  ASP b 139   N  ILE b 109           
SHEET    1 AG7 2 PHE b  21  LEU b  22  0                                        
SHEET    2 AG7 2 SER b 178  LEU b 179  1  O  SER b 178   N  LEU b  22           
SHEET    1 AG8 6 ALA c 142  VAL c 145  0                                        
SHEET    2 AG8 6 VAL c 108  SER c 114  1  N  HIS c 113   O  VAL c 143           
SHEET    3 AG8 6 GLY c  55  GLU c  60 -1  N  GLY c  55   O  TYR c 112           
SHEET    4 AG8 6 THR c  66  PHE c  73 -1  O  ASP c  71   N  LEU c  58           
SHEET    5 AG8 6 GLN c  30  ILE c  33  1  N  GLN c  30   O  VAL c  67           
SHEET    6 AG8 6 THR c 204  TYR c 207  1  O  THR c 204   N  VAL c  31           
SHEET    1 AG9 2 ARG c 161  LEU c 162  0                                        
SHEET    2 AG9 2 TYR c 200  TYR c 201 -1  O  TYR c 201   N  ARG c 161           
SHEET    1 AH1 2 LYS d 188  LEU d 190  0                                        
SHEET    2 AH1 2 ASN d 221  TYR d 223 -1  O  TYR d 222   N  ILE d 189           
SSBOND   1 CYS M   41    CYS M  186                          1555   1555  2.03  
CISPEP   1 ARG A   97    CYS A   98          0         0.90                     
CISPEP   2 ILE A  157    ASP A  158          0        -5.37                     
CISPEP   3 GLY A  205    ILE A  206          0        -0.59                     
CISPEP   4 GLY A  219    THR A  220          0        -4.82                     
CISPEP   5 GLN A  247    LYS A  248          0        -8.32                     
CISPEP   6 ALA A  283    ARG A  284          0         2.50                     
CISPEP   7 GLY A  288    ALA A  289          0        -3.03                     
CISPEP   8 GLY A  290    GLY A  291          0         4.87                     
CISPEP   9 ASP A  310    PRO A  311          0       -26.15                     
CISPEP  10 ARG A  312    GLY A  313          0       -10.02                     
CISPEP  11 ASP A  325    THR A  326          0         0.75                     
CISPEP  12 PHE A  343    SER A  344          0         6.76                     
CISPEP  13 SER A  344    LEU A  345          0        11.64                     
CISPEP  14 GLY B  104    THR B  105          0         0.55                     
CISPEP  15 SER B  126    VAL B  127          0        -1.21                     
CISPEP  16 VAL B  139    ASP B  140          0        -1.94                     
CISPEP  17 LYS B  155    VAL B  156          0       -15.38                     
CISPEP  18 ASP B  166    THR B  167          0        -0.32                     
CISPEP  19 GLU B  177    LYS B  178          0         3.37                     
CISPEP  20 PRO B  227    PRO B  228          0       -25.50                     
CISPEP  21 LEU B  260    GLY B  261          0        -0.74                     
CISPEP  22 GLY B  300    GLY B  301          0         5.22                     
CISPEP  23 ASP B  317    GLY B  318          0        -3.81                     
CISPEP  24 PHE B  319    ASP B  320          0        -2.22                     
CISPEP  25 ASP B  324    VAL B  325          0        -2.21                     
CISPEP  26 GLY B  345    ARG B  346          0        -4.05                     
CISPEP  27 ASP B  388    ASP B  389          0        -9.25                     
CISPEP  28 GLU B  436    GLY B  437          0         0.93                     
CISPEP  29 GLY B  437    LEU B  438          0       -20.94                     
CISPEP  30 GLU C   13    GLY C   14          0        -1.04                     
CISPEP  31 VAL C   99    ASP C  100          0         0.46                     
CISPEP  32 PRO C  192    GLY C  193          0        -9.01                     
CISPEP  33 SER C  215    GLY C  216          0        14.96                     
CISPEP  34 SER C  217    GLU C  218          0        16.59                     
CISPEP  35 ASP C  249    GLU C  250          0       -17.83                     
CISPEP  36 ALA C  285    THR C  286          0       -16.98                     
CISPEP  37 ARG C  310    ILE C  311          0       -11.21                     
CISPEP  38 ILE D   82    GLN D   83          0        -4.28                     
CISPEP  39 ILE D   85    PRO D   86          0        -1.03                     
CISPEP  40 PRO D  144    PRO D  145          0        -8.68                     
CISPEP  41 PRO D  145    GLU D  146          0        -1.38                     
CISPEP  42 LYS D  159    PRO D  160          0       -18.94                     
CISPEP  43 PRO D  207    PRO D  208          0         1.62                     
CISPEP  44 PRO D  208    GLY D  209          0         6.04                     
CISPEP  45 ALA D  258    PRO D  259          0        -5.95                     
CISPEP  46 ASP D  300    GLN D  301          0        -3.76                     
CISPEP  47 GLN D  301    ASN D  302          0       -25.75                     
CISPEP  48 VAL D  303    ASN D  304          0        -8.40                     
CISPEP  49 LEU D  354    SER D  355          0         9.06                     
CISPEP  50 GLY D  372    ALA D  373          0        -6.92                     
CISPEP  51 ALA D  373    ASP D  374          0         5.67                     
CISPEP  52 GLU D  389    ASN D  390          0         6.50                     
CISPEP  53 VAL D  406    ILE D  407          0        -0.15                     
CISPEP  54 GLU D  411    GLN D  412          0       -15.33                     
CISPEP  55 GLY E  128    ASN E  129          0       -14.22                     
CISPEP  56 GLY E  137    LEU E  138          0        -3.02                     
CISPEP  57 GLY E  174    PRO E  175          0       -15.94                     
CISPEP  58 GLN E  226    PRO E  227          0       -10.27                     
CISPEP  59 GLY E  266    PHE E  267          0         8.50                     
CISPEP  60 THR F   85    LEU F   86          0        -2.24                     
CISPEP  61 ASN F  102    ASP F  103          0         0.37                     
CISPEP  62 ILE F  137    GLY F  138          0         3.08                     
CISPEP  63 GLY F  138    LEU F  139          0        16.12                     
CISPEP  64 LYS F  144    LEU F  145          0         1.00                     
CISPEP  65 PRO F  165    THR F  166          0        -2.85                     
CISPEP  66 TYR F  168    ASP F  169          0        -5.09                     
CISPEP  67 PRO F  229    GLY F  230          0       -12.35                     
CISPEP  68 PRO F  280    SER F  281          0         7.12                     
CISPEP  69 SER F  298    GLU F  299          0        10.74                     
CISPEP  70 GLU F  299    LYS F  300          0        -3.59                     
CISPEP  71 GLN F  428    ALA F  429          0         7.58                     
CISPEP  72 LYS F  431    LYS F  432          0       -24.74                     
CISPEP  73 LYS G  184    LYS G  185          0       -15.16                     
CISPEP  74 ALA H  231    ALA H  232          0        20.92                     
CISPEP  75 ILE I  164    GLY I  165          0       -19.11                     
CISPEP  76 MET I  184    THR I  185          0       -29.01                     
CISPEP  77 ASN I  220    GLY I  221          0        -5.27                     
CISPEP  78 THR J    8    VAL J    9          0        -9.99                     
CISPEP  79 VAL J    9    PHE J   10          0       -22.04                     
CISPEP  80 ALA J  180    ILE J  181          0         1.07                     
CISPEP  81 GLU K   18    GLY K   19          0         0.18                     
CISPEP  82 ASN K  225    PHE K  226          0       -14.03                     
CISPEP  83 PHE K  226    HIS K  227          0        -4.52                     
CISPEP  84 HIS K  227    MET K  228          0        11.32                     
CISPEP  85 ASP L  204    LEU L  205          0         9.73                     
CISPEP  86 LYS M   56    LEU M   57          0        -9.51                     
CISPEP  87 ILE M  231    ARG M  232          0         3.03                     
CISPEP  88 ARG O  187    PRO O  188          0       -11.59                     
CISPEP  89 ILE Q  151    SER Q  152          0       -11.75                     
CISPEP  90 LEU U  118    PRO U  119          0       -12.45                     
CISPEP  91 ASP U  172    VAL U  173          0        -0.41                     
CISPEP  92 ASN U  470    ASP U  471          0        -3.75                     
CISPEP  93 LYS U  842    GLU U  843          0        18.01                     
CISPEP  94 LYS V   54    THR V   55          0        14.01                     
CISPEP  95 ALA V   56    ALA V   57          0         8.92                     
CISPEP  96 ALA V   57    ALA V   58          0         1.73                     
CISPEP  97 ALA V   59    ALA V   60          0         8.80                     
CISPEP  98 LYS V   76    GLU V   77          0        -4.03                     
CISPEP  99 LYS V   80    GLN V   81          0        21.91                     
CISPEP 100 GLN V   81    LEU V   82          0       -28.03                     
CISPEP 101 ALA V   97    LEU V   98          0       -17.14                     
CISPEP 102 LEU V   98    ARG V   99          0        -3.12                     
CISPEP 103 GLU V  142    ALA V  143          0         6.30                     
CISPEP 104 ASP V  144    LEU V  145          0       -10.94                     
CISPEP 105 THR V  239    LEU V  240          0        -3.17                     
CISPEP 106 SER V  262    LEU V  263          0         4.24                     
CISPEP 107 LYS V  273    SER V  274          0         1.00                     
CISPEP 108 VAL V  275    PHE V  276          0        11.01                     
CISPEP 109 PRO V  277    GLU V  278          0        -3.38                     
CISPEP 110 ALA V  280    ASN V  281          0        -3.30                     
CISPEP 111 PRO V  317    GLN V  318          0       -28.14                     
CISPEP 112 THR V  320    ALA V  321          0        18.99                     
CISPEP 113 ALA V  321    VAL V  322          0        -7.24                     
CISPEP 114 LYS V  455    GLY V  456          0        -1.82                     
CISPEP 115 LEU W   40    GLN W   41          0       -28.32                     
CISPEP 116 ARG W   65    ILE W   66          0        -3.53                     
CISPEP 117 ILE W   66    LEU W   67          0        -5.98                     
CISPEP 118 ASN W   86    ILE W   87          0        -5.61                     
CISPEP 119 SER W   91    LYS W   92          0       -17.84                     
CISPEP 120 LYS W   92    ARG W   93          0        10.81                     
CISPEP 121 LYS W  135    ILE W  136          0       -14.71                     
CISPEP 122 PHE W  213    PHE W  214          0         8.16                     
CISPEP 123 THR W  219    GLU W  220          0        13.18                     
CISPEP 124 GLU W  220    LYS W  221          0        -0.11                     
CISPEP 125 GLN W  257    ALA W  258          0         7.88                     
CISPEP 126 GLY W  331    SER W  332          0         2.91                     
CISPEP 127 TYR W  370    THR W  371          0         8.54                     
CISPEP 128 PRO X  203    PRO X  204          0       -12.11                     
CISPEP 129 TRP Y   63    GLN Y   64          0        -4.94                     
CISPEP 130 GLU Y  170    GLY Y  171          0         3.52                     
CISPEP 131 GLY Y  324    VAL Y  325          0         1.19                     
CISPEP 132 THR Y  356    ASN Y  357          0        -4.57                     
CISPEP 133 ILE Y  387    ASN Y  388          0        -1.45                     
CISPEP 134 GLY Z   30    ASN Z   31          0         0.90                     
CISPEP 135 LYS Z   63    ASP Z   64          0        16.70                     
CISPEP 136 GLY Z   98    PRO Z   99          0         2.03                     
CISPEP 137 ASP Z  130    LEU Z  131          0        -7.15                     
CISPEP 138 ASP Z  181    THR Z  182          0        -1.94                     
CISPEP 139 THR Z  182    THR Z  183          0         7.50                     
CISPEP 140 LYS Z  219    LEU Z  220          0         4.62                     
CISPEP 141 LEU Z  220    PRO Z  221          0         8.16                     
CISPEP 142 ILE Z  222    ASN Z  223          0        13.33                     
CISPEP 143 ASN Z  223    HIS Z  224          0         4.16                     
CISPEP 144 HIS Z  224    GLN Z  225          0        -9.70                     
CISPEP 145 PRO Z  238    ASP Z  239          0       -21.39                     
CISPEP 146 SER Z  241    LEU Z  242          0       -11.15                     
CISPEP 147 PHE a   50    ALA a   51          0         1.83                     
CISPEP 148 ILE a  125    GLY a  126          0        -9.47                     
CISPEP 149 ASN a  144    LEU a  145          0        -4.66                     
CISPEP 150 ILE a  166    GLY a  167          0         1.46                     
CISPEP 151 GLY a  243    ASN a  244          0        -7.25                     
CISPEP 152 VAL a  245    GLU a  246          0        -3.59                     
CISPEP 153 ASN a  287    HIS a  288          0        -3.37                     
CISPEP 154 LEU b   22    PRO b   23          0        -9.76                     
CISPEP 155 LYS b  163    ASP b  164          0        -4.75                     
CISPEP 156 ASP b  164    GLY b  165          0        -3.60                     
CISPEP 157 THR b  166    GLY b  167          0         0.54                     
CISPEP 158 VAL c   49    PRO c   50          0        -1.53                     
CISPEP 159 PRO c  174    ARG c  175          0         5.91                     
CISPEP 160 LYS c  186    PRO c  187          0        -1.89                     
CISPEP 161 ILE c  272    LYS c  273          0         7.20                     
CISPEP 162 LYS c  273    ASN c  274          0        -9.93                     
CISPEP 163 ASN c  274    VAL c  275          0       -10.89                     
CISPEP 164 ASP c  279    PRO c  280          0        -4.14                     
CISPEP 165 GLU c  285    GLU c  286          0       -12.81                     
CISPEP 166 LEU d   36    PRO d   37          0       -16.81                     
CISPEP 167 GLY d   40    THR d   41          0        -0.56                     
CISPEP 168 GLU d  145    GLY d  146          0         1.55                     
CISPEP 169 SER d  147    TYR d  148          0         9.22                     
CISPEP 170 PRO d  159    ALA d  160          0       -12.83                     
CISPEP 171 ALA d  160    GLU d  161          0        -8.43                     
CISPEP 172 GLU d  183    LYS d  184          0         5.49                     
CISPEP 173 LYS d  184    ALA d  185          0        -2.73                     
CISPEP 174 GLY d  214    TRP d  215          0        21.07                     
CISPEP 175 PHE d  225    ALA d  226          0        -1.90                     
CISPEP 176 ALA d  226    SER d  227          0       -11.91                     
CISPEP 177 GLN d  228    GLN d  229          0        11.54                     
CISPEP 178 GLU d  233    ASP d  234          0        -2.47                     
CISPEP 179 ILE d  256    VAL d  257          0         0.05                     
CISPEP 180 MET e    1    SER e    2          0        -3.58                     
CISPEP 181 GLU e   40    ASP e   41          0         3.23                     
CISPEP 182 ALA e   58    GLU e   59          0         0.32                     
CISPEP 183 TRP f   11    GLN f   12          0         2.38                     
CISPEP 184 PHE f  103    PRO f  104          0        -5.41                     
CISPEP 185 ALA f  106    LEU f  107          0       -20.62                     
CISPEP 186 LEU f  109    ALA f  110          0        -0.14                     
CISPEP 187 THR f  192    HIS f  193          0         1.52                     
CISPEP 188 HIS f  193    LEU f  194          0        -6.90                     
CISPEP 189 SER f  208    ALA f  209          0        -3.06                     
CISPEP 190 GLY f  266    LEU f  267          0         1.08                     
CISPEP 191 ARG f  297    ASN f  298          0        -7.46                     
CISPEP 192 ASN f  298    GLU f  299          0        -5.88                     
CISPEP 193 ASN f  334    ARG f  335          0        -7.35                     
CISPEP 194 ARG f  335    GLU f  336          0        -5.01                     
CISPEP 195 LYS f  350    SER f  351          0         1.66                     
CISPEP 196 SER f  370    CYS f  371          0        -4.74                     
CISPEP 197 ASN f  372    GLY f  373          0         0.38                     
CISPEP 198 GLU f  390    LEU f  391          0        -8.64                     
CISPEP 199 GLY f  615    THR f  616          0        -6.06                     
CISPEP 200 LEU f  617    THR f  618          0        -1.31                     
CISPEP 201 THR f  618    LEU f  619          0         4.85                     
CISPEP 202 GLY f  636    LEU f  637          0       -24.00                     
CISPEP 203 LEU f  638    THR f  639          0         0.31                     
CISPEP 204 TYR f  660    GLY f  661          0       -12.22                     
CISPEP 205 GLY f  661    LEU f  662          0       -11.58                     
CISPEP 206 LEU f  662    VAL f  663          0        -2.82                     
CISPEP 207 VAL f  663    ALA f  664          0        -4.39                     
SITE     1 AC1 17 ASP A 176  GLY A 178  PRO A 218  GLY A 219                    
SITE     2 AC1 17 THR A 220  GLY A 221  LYS A 222  THR A 223                    
SITE     3 AC1 17 THR A 321  ASN A 322  THR A 381  GLY A 382                    
SITE     4 AC1 17 ALA A 383  ASP B 317  ALA B 340  ARG B 343                    
SITE     5 AC1 17 PRO B 344                                                     
SITE     1 AC2 10 CYS D 210  LYS D 212  THR D 213  MET D 214                    
SITE     2 AC2 10 GLU D 266  ILE D 344  THR D 347  ASN D 376                    
SITE     3 AC2 10 GLN D 380  ARG E 294                                          
SITE     1 AC3 17 ILE E 135  PRO E 175  THR E 178  GLY E 179                    
SITE     2 AC3 17 LYS E 180  THR E 181  LEU E 182  ILE E 312                    
SITE     3 AC3 17 ILE E 315  HIS E 316  ASN E 339  GLY E 340                    
SITE     4 AC3 17 ALA E 341  ASP F 318  ALA F 341  ARG F 344                    
SITE     5 AC3 17 ARG F 347                                                     
SITE     1 AC4 14 GLY A 335  ILE F 188  GLY F 230  THR F 231                    
SITE     2 AC4 14 GLY F 232  LYS F 233  THR F 234  LEU F 235                    
SITE     3 AC4 14 ASP F 286  ASN F 333  HIS F 369  GLY F 393                    
SITE     4 AC4 14 ALA F 394  LYS F 397                                          
SITE     1 AC5  3 HIS c 115  SER c 123  ASP c 126                               
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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