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Database: PDB
Entry: 5U6O
LinkDB: 5U6O
Original site: 5U6O 
HEADER    TRANSPORT PROTEIN                       08-DEC-16   5U6O              
TITLE     STRUCTURE OF THE HUMAN HCN1 HYPERPOLARIZATION-ACTIVATED CYCLIC        
TITLE    2 NUCLEOTIDE-GATED ION CHANNEL                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC        
COMPND   3 NUCLEOTIDE-GATED CHANNEL 1;                                          
COMPND   4 CHAIN: A, B, C, D;                                                   
COMPND   5 FRAGMENT: UNP RESIDUES 1-635,866-890;                                
COMPND   6 SYNONYM: BRAIN CYCLIC NUCLEOTIDE-GATED CHANNEL 1, BCNG-1;            
COMPND   7 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: HCN1, BCNG1;                                                   
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    PACEMAKER ION CHANNEL, TRANSPORT PROTEIN                              
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    C.-H.LEE,R.MACKINNON                                                  
REVDAT   3   13-MAR-24 5U6O    1       REMARK                                   
REVDAT   2   27-SEP-17 5U6O    1       REMARK                                   
REVDAT   1   25-JAN-17 5U6O    0                                                
JRNL        AUTH   C.H.LEE,R.MACKINNON                                          
JRNL        TITL   STRUCTURES OF THE HUMAN HCN1 HYPERPOLARIZATION-ACTIVATED     
JRNL        TITL 2 CHANNEL.                                                     
JRNL        REF    CELL                          V. 168   111 2017              
JRNL        REFN                   ISSN 1097-4172                               
JRNL        PMID   28086084                                                     
JRNL        DOI    10.1016/J.CELL.2016.12.023                                   
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.50 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.500                          
REMARK   3   NUMBER OF PARTICLES               : 55870                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5U6O COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 15-DEC-16.                  
REMARK 100 THE DEPOSITION ID IS D_1000225402.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : HUMAN HCN1 HYPERPOLARIZATION      
REMARK 245                                    -ACTIVATED CYCLIC NUCLEOTIDE-     
REMARK 245                                    GATED ION CHANNEL                 
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 5.00                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : 1500.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3300.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 126.00                         
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     GLU A     2                                                      
REMARK 465     GLY A     3                                                      
REMARK 465     GLY A     4                                                      
REMARK 465     GLY A     5                                                      
REMARK 465     LYS A     6                                                      
REMARK 465     PRO A     7                                                      
REMARK 465     ASN A     8                                                      
REMARK 465     SER A     9                                                      
REMARK 465     SER A    10                                                      
REMARK 465     SER A    11                                                      
REMARK 465     ASN A    12                                                      
REMARK 465     SER A    13                                                      
REMARK 465     ARG A    14                                                      
REMARK 465     ASP A    15                                                      
REMARK 465     ASP A    16                                                      
REMARK 465     GLY A    17                                                      
REMARK 465     ASN A    18                                                      
REMARK 465     SER A    19                                                      
REMARK 465     VAL A    20                                                      
REMARK 465     PHE A    21                                                      
REMARK 465     PRO A    22                                                      
REMARK 465     ALA A    23                                                      
REMARK 465     LYS A    24                                                      
REMARK 465     ALA A    25                                                      
REMARK 465     SER A    26                                                      
REMARK 465     ALA A    27                                                      
REMARK 465     THR A    28                                                      
REMARK 465     GLY A    29                                                      
REMARK 465     ALA A    30                                                      
REMARK 465     GLY A    31                                                      
REMARK 465     PRO A    32                                                      
REMARK 465     ALA A    33                                                      
REMARK 465     ALA A    34                                                      
REMARK 465     ALA A    35                                                      
REMARK 465     GLU A    36                                                      
REMARK 465     LYS A    37                                                      
REMARK 465     ARG A    38                                                      
REMARK 465     LEU A    39                                                      
REMARK 465     GLY A    40                                                      
REMARK 465     THR A    41                                                      
REMARK 465     PRO A    42                                                      
REMARK 465     PRO A    43                                                      
REMARK 465     GLY A    44                                                      
REMARK 465     GLY A    45                                                      
REMARK 465     GLY A    46                                                      
REMARK 465     GLY A    47                                                      
REMARK 465     ALA A    48                                                      
REMARK 465     GLY A    49                                                      
REMARK 465     ALA A    50                                                      
REMARK 465     LYS A    51                                                      
REMARK 465     GLU A    52                                                      
REMARK 465     HIS A    53                                                      
REMARK 465     GLY A    54                                                      
REMARK 465     ASN A    55                                                      
REMARK 465     SER A    56                                                      
REMARK 465     VAL A    57                                                      
REMARK 465     CYS A    58                                                      
REMARK 465     PHE A    59                                                      
REMARK 465     LYS A    60                                                      
REMARK 465     VAL A    61                                                      
REMARK 465     ASP A    62                                                      
REMARK 465     GLY A    63                                                      
REMARK 465     GLY A    64                                                      
REMARK 465     GLY A    65                                                      
REMARK 465     GLY A    66                                                      
REMARK 465     GLY A    67                                                      
REMARK 465     GLY A    68                                                      
REMARK 465     GLY A    69                                                      
REMARK 465     GLY A    70                                                      
REMARK 465     GLY A    71                                                      
REMARK 465     GLY A    72                                                      
REMARK 465     GLY A    73                                                      
REMARK 465     GLY A    74                                                      
REMARK 465     GLU A    75                                                      
REMARK 465     GLU A    76                                                      
REMARK 465     PRO A    77                                                      
REMARK 465     ALA A    78                                                      
REMARK 465     GLY A    79                                                      
REMARK 465     GLY A    80                                                      
REMARK 465     PHE A    81                                                      
REMARK 465     GLU A    82                                                      
REMARK 465     ASP A    83                                                      
REMARK 465     ALA A    84                                                      
REMARK 465     GLU A    85                                                      
REMARK 465     GLY A    86                                                      
REMARK 465     PRO A    87                                                      
REMARK 465     ARG A    88                                                      
REMARK 465     ARG A    89                                                      
REMARK 465     GLN A    90                                                      
REMARK 465     TYR A    91                                                      
REMARK 465     GLY A    92                                                      
REMARK 465     PHE A    93                                                      
REMARK 465     GLU A   201                                                      
REMARK 465     ASP A   202                                                      
REMARK 465     MET A   243                                                      
REMARK 465     ASP A   244                                                      
REMARK 465     SER A   245                                                      
REMARK 465     GLU A   246                                                      
REMARK 465     VAL A   247                                                      
REMARK 465     TYR A   248                                                      
REMARK 465     LYS A   249                                                      
REMARK 465     THR A   250                                                      
REMARK 465     ALA A   251                                                      
REMARK 465     ALA A   587                                                      
REMARK 465     ILE A   588                                                      
REMARK 465     ASP A   589                                                      
REMARK 465     ARG A   590                                                      
REMARK 465     LEU A   591                                                      
REMARK 465     ASP A   592                                                      
REMARK 465     ARG A   593                                                      
REMARK 465     ILE A   594                                                      
REMARK 465     GLY A   595                                                      
REMARK 465     LYS A   596                                                      
REMARK 465     LYS A   597                                                      
REMARK 465     ASN A   598                                                      
REMARK 465     SER A   599                                                      
REMARK 465     ILE A   600                                                      
REMARK 465     LEU A   601                                                      
REMARK 465     LEU A   602                                                      
REMARK 465     GLN A   603                                                      
REMARK 465     LYS A   604                                                      
REMARK 465     PHE A   605                                                      
REMARK 465     GLN A   606                                                      
REMARK 465     LYS A   607                                                      
REMARK 465     ASP A   608                                                      
REMARK 465     LEU A   609                                                      
REMARK 465     ASN A   610                                                      
REMARK 465     THR A   611                                                      
REMARK 465     GLY A   612                                                      
REMARK 465     VAL A   613                                                      
REMARK 465     PHE A   614                                                      
REMARK 465     ASN A   615                                                      
REMARK 465     ASN A   616                                                      
REMARK 465     GLN A   617                                                      
REMARK 465     GLU A   618                                                      
REMARK 465     ASN A   619                                                      
REMARK 465     GLU A   620                                                      
REMARK 465     ILE A   621                                                      
REMARK 465     LEU A   622                                                      
REMARK 465     LYS A   623                                                      
REMARK 465     GLN A   624                                                      
REMARK 465     ILE A   625                                                      
REMARK 465     VAL A   626                                                      
REMARK 465     LYS A   627                                                      
REMARK 465     HIS A   628                                                      
REMARK 465     ASP A   629                                                      
REMARK 465     ARG A   630                                                      
REMARK 465     GLU A   631                                                      
REMARK 465     MET A   632                                                      
REMARK 465     VAL A   633                                                      
REMARK 465     GLN A   634                                                      
REMARK 465     ALA A   635                                                      
REMARK 465     ALA A   636                                                      
REMARK 465     LEU A   637                                                      
REMARK 465     PRO A   638                                                      
REMARK 465     ARG A   639                                                      
REMARK 465     GLU A   640                                                      
REMARK 465     SER A   641                                                      
REMARK 465     SER A   642                                                      
REMARK 465     SER A   643                                                      
REMARK 465     VAL A   644                                                      
REMARK 465     LEU A   645                                                      
REMARK 465     ASN A   646                                                      
REMARK 465     THR A   647                                                      
REMARK 465     ASP A   648                                                      
REMARK 465     PRO A   649                                                      
REMARK 465     ASP A   650                                                      
REMARK 465     ALA A   651                                                      
REMARK 465     GLU A   652                                                      
REMARK 465     LYS A   653                                                      
REMARK 465     PRO A   654                                                      
REMARK 465     ARG A   655                                                      
REMARK 465     PHE A   656                                                      
REMARK 465     ALA A   657                                                      
REMARK 465     SER A   658                                                      
REMARK 465     ASN A   659                                                      
REMARK 465     LEU A   660                                                      
REMARK 465     MET B     1                                                      
REMARK 465     GLU B     2                                                      
REMARK 465     GLY B     3                                                      
REMARK 465     GLY B     4                                                      
REMARK 465     GLY B     5                                                      
REMARK 465     LYS B     6                                                      
REMARK 465     PRO B     7                                                      
REMARK 465     ASN B     8                                                      
REMARK 465     SER B     9                                                      
REMARK 465     SER B    10                                                      
REMARK 465     SER B    11                                                      
REMARK 465     ASN B    12                                                      
REMARK 465     SER B    13                                                      
REMARK 465     ARG B    14                                                      
REMARK 465     ASP B    15                                                      
REMARK 465     ASP B    16                                                      
REMARK 465     GLY B    17                                                      
REMARK 465     ASN B    18                                                      
REMARK 465     SER B    19                                                      
REMARK 465     VAL B    20                                                      
REMARK 465     PHE B    21                                                      
REMARK 465     PRO B    22                                                      
REMARK 465     ALA B    23                                                      
REMARK 465     LYS B    24                                                      
REMARK 465     ALA B    25                                                      
REMARK 465     SER B    26                                                      
REMARK 465     ALA B    27                                                      
REMARK 465     THR B    28                                                      
REMARK 465     GLY B    29                                                      
REMARK 465     ALA B    30                                                      
REMARK 465     GLY B    31                                                      
REMARK 465     PRO B    32                                                      
REMARK 465     ALA B    33                                                      
REMARK 465     ALA B    34                                                      
REMARK 465     ALA B    35                                                      
REMARK 465     GLU B    36                                                      
REMARK 465     LYS B    37                                                      
REMARK 465     ARG B    38                                                      
REMARK 465     LEU B    39                                                      
REMARK 465     GLY B    40                                                      
REMARK 465     THR B    41                                                      
REMARK 465     PRO B    42                                                      
REMARK 465     PRO B    43                                                      
REMARK 465     GLY B    44                                                      
REMARK 465     GLY B    45                                                      
REMARK 465     GLY B    46                                                      
REMARK 465     GLY B    47                                                      
REMARK 465     ALA B    48                                                      
REMARK 465     GLY B    49                                                      
REMARK 465     ALA B    50                                                      
REMARK 465     LYS B    51                                                      
REMARK 465     GLU B    52                                                      
REMARK 465     HIS B    53                                                      
REMARK 465     GLY B    54                                                      
REMARK 465     ASN B    55                                                      
REMARK 465     SER B    56                                                      
REMARK 465     VAL B    57                                                      
REMARK 465     CYS B    58                                                      
REMARK 465     PHE B    59                                                      
REMARK 465     LYS B    60                                                      
REMARK 465     VAL B    61                                                      
REMARK 465     ASP B    62                                                      
REMARK 465     GLY B    63                                                      
REMARK 465     GLY B    64                                                      
REMARK 465     GLY B    65                                                      
REMARK 465     GLY B    66                                                      
REMARK 465     GLY B    67                                                      
REMARK 465     GLY B    68                                                      
REMARK 465     GLY B    69                                                      
REMARK 465     GLY B    70                                                      
REMARK 465     GLY B    71                                                      
REMARK 465     GLY B    72                                                      
REMARK 465     GLY B    73                                                      
REMARK 465     GLY B    74                                                      
REMARK 465     GLU B    75                                                      
REMARK 465     GLU B    76                                                      
REMARK 465     PRO B    77                                                      
REMARK 465     ALA B    78                                                      
REMARK 465     GLY B    79                                                      
REMARK 465     GLY B    80                                                      
REMARK 465     PHE B    81                                                      
REMARK 465     GLU B    82                                                      
REMARK 465     ASP B    83                                                      
REMARK 465     ALA B    84                                                      
REMARK 465     GLU B    85                                                      
REMARK 465     GLY B    86                                                      
REMARK 465     PRO B    87                                                      
REMARK 465     ARG B    88                                                      
REMARK 465     ARG B    89                                                      
REMARK 465     GLN B    90                                                      
REMARK 465     TYR B    91                                                      
REMARK 465     GLY B    92                                                      
REMARK 465     PHE B    93                                                      
REMARK 465     GLU B   201                                                      
REMARK 465     ASP B   202                                                      
REMARK 465     MET B   243                                                      
REMARK 465     ASP B   244                                                      
REMARK 465     SER B   245                                                      
REMARK 465     GLU B   246                                                      
REMARK 465     VAL B   247                                                      
REMARK 465     TYR B   248                                                      
REMARK 465     LYS B   249                                                      
REMARK 465     THR B   250                                                      
REMARK 465     ALA B   251                                                      
REMARK 465     ALA B   587                                                      
REMARK 465     ILE B   588                                                      
REMARK 465     ASP B   589                                                      
REMARK 465     ARG B   590                                                      
REMARK 465     LEU B   591                                                      
REMARK 465     ASP B   592                                                      
REMARK 465     ARG B   593                                                      
REMARK 465     ILE B   594                                                      
REMARK 465     GLY B   595                                                      
REMARK 465     LYS B   596                                                      
REMARK 465     LYS B   597                                                      
REMARK 465     ASN B   598                                                      
REMARK 465     SER B   599                                                      
REMARK 465     ILE B   600                                                      
REMARK 465     LEU B   601                                                      
REMARK 465     LEU B   602                                                      
REMARK 465     GLN B   603                                                      
REMARK 465     LYS B   604                                                      
REMARK 465     PHE B   605                                                      
REMARK 465     GLN B   606                                                      
REMARK 465     LYS B   607                                                      
REMARK 465     ASP B   608                                                      
REMARK 465     LEU B   609                                                      
REMARK 465     ASN B   610                                                      
REMARK 465     THR B   611                                                      
REMARK 465     GLY B   612                                                      
REMARK 465     VAL B   613                                                      
REMARK 465     PHE B   614                                                      
REMARK 465     ASN B   615                                                      
REMARK 465     ASN B   616                                                      
REMARK 465     GLN B   617                                                      
REMARK 465     GLU B   618                                                      
REMARK 465     ASN B   619                                                      
REMARK 465     GLU B   620                                                      
REMARK 465     ILE B   621                                                      
REMARK 465     LEU B   622                                                      
REMARK 465     LYS B   623                                                      
REMARK 465     GLN B   624                                                      
REMARK 465     ILE B   625                                                      
REMARK 465     VAL B   626                                                      
REMARK 465     LYS B   627                                                      
REMARK 465     HIS B   628                                                      
REMARK 465     ASP B   629                                                      
REMARK 465     ARG B   630                                                      
REMARK 465     GLU B   631                                                      
REMARK 465     MET B   632                                                      
REMARK 465     VAL B   633                                                      
REMARK 465     GLN B   634                                                      
REMARK 465     ALA B   635                                                      
REMARK 465     ALA B   636                                                      
REMARK 465     LEU B   637                                                      
REMARK 465     PRO B   638                                                      
REMARK 465     ARG B   639                                                      
REMARK 465     GLU B   640                                                      
REMARK 465     SER B   641                                                      
REMARK 465     SER B   642                                                      
REMARK 465     SER B   643                                                      
REMARK 465     VAL B   644                                                      
REMARK 465     LEU B   645                                                      
REMARK 465     ASN B   646                                                      
REMARK 465     THR B   647                                                      
REMARK 465     ASP B   648                                                      
REMARK 465     PRO B   649                                                      
REMARK 465     ASP B   650                                                      
REMARK 465     ALA B   651                                                      
REMARK 465     GLU B   652                                                      
REMARK 465     LYS B   653                                                      
REMARK 465     PRO B   654                                                      
REMARK 465     ARG B   655                                                      
REMARK 465     PHE B   656                                                      
REMARK 465     ALA B   657                                                      
REMARK 465     SER B   658                                                      
REMARK 465     ASN B   659                                                      
REMARK 465     LEU B   660                                                      
REMARK 465     MET C     1                                                      
REMARK 465     GLU C     2                                                      
REMARK 465     GLY C     3                                                      
REMARK 465     GLY C     4                                                      
REMARK 465     GLY C     5                                                      
REMARK 465     LYS C     6                                                      
REMARK 465     PRO C     7                                                      
REMARK 465     ASN C     8                                                      
REMARK 465     SER C     9                                                      
REMARK 465     SER C    10                                                      
REMARK 465     SER C    11                                                      
REMARK 465     ASN C    12                                                      
REMARK 465     SER C    13                                                      
REMARK 465     ARG C    14                                                      
REMARK 465     ASP C    15                                                      
REMARK 465     ASP C    16                                                      
REMARK 465     GLY C    17                                                      
REMARK 465     ASN C    18                                                      
REMARK 465     SER C    19                                                      
REMARK 465     VAL C    20                                                      
REMARK 465     PHE C    21                                                      
REMARK 465     PRO C    22                                                      
REMARK 465     ALA C    23                                                      
REMARK 465     LYS C    24                                                      
REMARK 465     ALA C    25                                                      
REMARK 465     SER C    26                                                      
REMARK 465     ALA C    27                                                      
REMARK 465     THR C    28                                                      
REMARK 465     GLY C    29                                                      
REMARK 465     ALA C    30                                                      
REMARK 465     GLY C    31                                                      
REMARK 465     PRO C    32                                                      
REMARK 465     ALA C    33                                                      
REMARK 465     ALA C    34                                                      
REMARK 465     ALA C    35                                                      
REMARK 465     GLU C    36                                                      
REMARK 465     LYS C    37                                                      
REMARK 465     ARG C    38                                                      
REMARK 465     LEU C    39                                                      
REMARK 465     GLY C    40                                                      
REMARK 465     THR C    41                                                      
REMARK 465     PRO C    42                                                      
REMARK 465     PRO C    43                                                      
REMARK 465     GLY C    44                                                      
REMARK 465     GLY C    45                                                      
REMARK 465     GLY C    46                                                      
REMARK 465     GLY C    47                                                      
REMARK 465     ALA C    48                                                      
REMARK 465     GLY C    49                                                      
REMARK 465     ALA C    50                                                      
REMARK 465     LYS C    51                                                      
REMARK 465     GLU C    52                                                      
REMARK 465     HIS C    53                                                      
REMARK 465     GLY C    54                                                      
REMARK 465     ASN C    55                                                      
REMARK 465     SER C    56                                                      
REMARK 465     VAL C    57                                                      
REMARK 465     CYS C    58                                                      
REMARK 465     PHE C    59                                                      
REMARK 465     LYS C    60                                                      
REMARK 465     VAL C    61                                                      
REMARK 465     ASP C    62                                                      
REMARK 465     GLY C    63                                                      
REMARK 465     GLY C    64                                                      
REMARK 465     GLY C    65                                                      
REMARK 465     GLY C    66                                                      
REMARK 465     GLY C    67                                                      
REMARK 465     GLY C    68                                                      
REMARK 465     GLY C    69                                                      
REMARK 465     GLY C    70                                                      
REMARK 465     GLY C    71                                                      
REMARK 465     GLY C    72                                                      
REMARK 465     GLY C    73                                                      
REMARK 465     GLY C    74                                                      
REMARK 465     GLU C    75                                                      
REMARK 465     GLU C    76                                                      
REMARK 465     PRO C    77                                                      
REMARK 465     ALA C    78                                                      
REMARK 465     GLY C    79                                                      
REMARK 465     GLY C    80                                                      
REMARK 465     PHE C    81                                                      
REMARK 465     GLU C    82                                                      
REMARK 465     ASP C    83                                                      
REMARK 465     ALA C    84                                                      
REMARK 465     GLU C    85                                                      
REMARK 465     GLY C    86                                                      
REMARK 465     PRO C    87                                                      
REMARK 465     ARG C    88                                                      
REMARK 465     ARG C    89                                                      
REMARK 465     GLN C    90                                                      
REMARK 465     TYR C    91                                                      
REMARK 465     GLY C    92                                                      
REMARK 465     PHE C    93                                                      
REMARK 465     GLU C   201                                                      
REMARK 465     ASP C   202                                                      
REMARK 465     MET C   243                                                      
REMARK 465     ASP C   244                                                      
REMARK 465     SER C   245                                                      
REMARK 465     GLU C   246                                                      
REMARK 465     VAL C   247                                                      
REMARK 465     TYR C   248                                                      
REMARK 465     LYS C   249                                                      
REMARK 465     THR C   250                                                      
REMARK 465     ALA C   251                                                      
REMARK 465     ALA C   587                                                      
REMARK 465     ILE C   588                                                      
REMARK 465     ASP C   589                                                      
REMARK 465     ARG C   590                                                      
REMARK 465     LEU C   591                                                      
REMARK 465     ASP C   592                                                      
REMARK 465     ARG C   593                                                      
REMARK 465     ILE C   594                                                      
REMARK 465     GLY C   595                                                      
REMARK 465     LYS C   596                                                      
REMARK 465     LYS C   597                                                      
REMARK 465     ASN C   598                                                      
REMARK 465     SER C   599                                                      
REMARK 465     ILE C   600                                                      
REMARK 465     LEU C   601                                                      
REMARK 465     LEU C   602                                                      
REMARK 465     GLN C   603                                                      
REMARK 465     LYS C   604                                                      
REMARK 465     PHE C   605                                                      
REMARK 465     GLN C   606                                                      
REMARK 465     LYS C   607                                                      
REMARK 465     ASP C   608                                                      
REMARK 465     LEU C   609                                                      
REMARK 465     ASN C   610                                                      
REMARK 465     THR C   611                                                      
REMARK 465     GLY C   612                                                      
REMARK 465     VAL C   613                                                      
REMARK 465     PHE C   614                                                      
REMARK 465     ASN C   615                                                      
REMARK 465     ASN C   616                                                      
REMARK 465     GLN C   617                                                      
REMARK 465     GLU C   618                                                      
REMARK 465     ASN C   619                                                      
REMARK 465     GLU C   620                                                      
REMARK 465     ILE C   621                                                      
REMARK 465     LEU C   622                                                      
REMARK 465     LYS C   623                                                      
REMARK 465     GLN C   624                                                      
REMARK 465     ILE C   625                                                      
REMARK 465     VAL C   626                                                      
REMARK 465     LYS C   627                                                      
REMARK 465     HIS C   628                                                      
REMARK 465     ASP C   629                                                      
REMARK 465     ARG C   630                                                      
REMARK 465     GLU C   631                                                      
REMARK 465     MET C   632                                                      
REMARK 465     VAL C   633                                                      
REMARK 465     GLN C   634                                                      
REMARK 465     ALA C   635                                                      
REMARK 465     ALA C   636                                                      
REMARK 465     LEU C   637                                                      
REMARK 465     PRO C   638                                                      
REMARK 465     ARG C   639                                                      
REMARK 465     GLU C   640                                                      
REMARK 465     SER C   641                                                      
REMARK 465     SER C   642                                                      
REMARK 465     SER C   643                                                      
REMARK 465     VAL C   644                                                      
REMARK 465     LEU C   645                                                      
REMARK 465     ASN C   646                                                      
REMARK 465     THR C   647                                                      
REMARK 465     ASP C   648                                                      
REMARK 465     PRO C   649                                                      
REMARK 465     ASP C   650                                                      
REMARK 465     ALA C   651                                                      
REMARK 465     GLU C   652                                                      
REMARK 465     LYS C   653                                                      
REMARK 465     PRO C   654                                                      
REMARK 465     ARG C   655                                                      
REMARK 465     PHE C   656                                                      
REMARK 465     ALA C   657                                                      
REMARK 465     SER C   658                                                      
REMARK 465     ASN C   659                                                      
REMARK 465     LEU C   660                                                      
REMARK 465     MET D     1                                                      
REMARK 465     GLU D     2                                                      
REMARK 465     GLY D     3                                                      
REMARK 465     GLY D     4                                                      
REMARK 465     GLY D     5                                                      
REMARK 465     LYS D     6                                                      
REMARK 465     PRO D     7                                                      
REMARK 465     ASN D     8                                                      
REMARK 465     SER D     9                                                      
REMARK 465     SER D    10                                                      
REMARK 465     SER D    11                                                      
REMARK 465     ASN D    12                                                      
REMARK 465     SER D    13                                                      
REMARK 465     ARG D    14                                                      
REMARK 465     ASP D    15                                                      
REMARK 465     ASP D    16                                                      
REMARK 465     GLY D    17                                                      
REMARK 465     ASN D    18                                                      
REMARK 465     SER D    19                                                      
REMARK 465     VAL D    20                                                      
REMARK 465     PHE D    21                                                      
REMARK 465     PRO D    22                                                      
REMARK 465     ALA D    23                                                      
REMARK 465     LYS D    24                                                      
REMARK 465     ALA D    25                                                      
REMARK 465     SER D    26                                                      
REMARK 465     ALA D    27                                                      
REMARK 465     THR D    28                                                      
REMARK 465     GLY D    29                                                      
REMARK 465     ALA D    30                                                      
REMARK 465     GLY D    31                                                      
REMARK 465     PRO D    32                                                      
REMARK 465     ALA D    33                                                      
REMARK 465     ALA D    34                                                      
REMARK 465     ALA D    35                                                      
REMARK 465     GLU D    36                                                      
REMARK 465     LYS D    37                                                      
REMARK 465     ARG D    38                                                      
REMARK 465     LEU D    39                                                      
REMARK 465     GLY D    40                                                      
REMARK 465     THR D    41                                                      
REMARK 465     PRO D    42                                                      
REMARK 465     PRO D    43                                                      
REMARK 465     GLY D    44                                                      
REMARK 465     GLY D    45                                                      
REMARK 465     GLY D    46                                                      
REMARK 465     GLY D    47                                                      
REMARK 465     ALA D    48                                                      
REMARK 465     GLY D    49                                                      
REMARK 465     ALA D    50                                                      
REMARK 465     LYS D    51                                                      
REMARK 465     GLU D    52                                                      
REMARK 465     HIS D    53                                                      
REMARK 465     GLY D    54                                                      
REMARK 465     ASN D    55                                                      
REMARK 465     SER D    56                                                      
REMARK 465     VAL D    57                                                      
REMARK 465     CYS D    58                                                      
REMARK 465     PHE D    59                                                      
REMARK 465     LYS D    60                                                      
REMARK 465     VAL D    61                                                      
REMARK 465     ASP D    62                                                      
REMARK 465     GLY D    63                                                      
REMARK 465     GLY D    64                                                      
REMARK 465     GLY D    65                                                      
REMARK 465     GLY D    66                                                      
REMARK 465     GLY D    67                                                      
REMARK 465     GLY D    68                                                      
REMARK 465     GLY D    69                                                      
REMARK 465     GLY D    70                                                      
REMARK 465     GLY D    71                                                      
REMARK 465     GLY D    72                                                      
REMARK 465     GLY D    73                                                      
REMARK 465     GLY D    74                                                      
REMARK 465     GLU D    75                                                      
REMARK 465     GLU D    76                                                      
REMARK 465     PRO D    77                                                      
REMARK 465     ALA D    78                                                      
REMARK 465     GLY D    79                                                      
REMARK 465     GLY D    80                                                      
REMARK 465     PHE D    81                                                      
REMARK 465     GLU D    82                                                      
REMARK 465     ASP D    83                                                      
REMARK 465     ALA D    84                                                      
REMARK 465     GLU D    85                                                      
REMARK 465     GLY D    86                                                      
REMARK 465     PRO D    87                                                      
REMARK 465     ARG D    88                                                      
REMARK 465     ARG D    89                                                      
REMARK 465     GLN D    90                                                      
REMARK 465     TYR D    91                                                      
REMARK 465     GLY D    92                                                      
REMARK 465     PHE D    93                                                      
REMARK 465     GLU D   201                                                      
REMARK 465     ASP D   202                                                      
REMARK 465     MET D   243                                                      
REMARK 465     ASP D   244                                                      
REMARK 465     SER D   245                                                      
REMARK 465     GLU D   246                                                      
REMARK 465     VAL D   247                                                      
REMARK 465     TYR D   248                                                      
REMARK 465     LYS D   249                                                      
REMARK 465     THR D   250                                                      
REMARK 465     ALA D   251                                                      
REMARK 465     ALA D   587                                                      
REMARK 465     ILE D   588                                                      
REMARK 465     ASP D   589                                                      
REMARK 465     ARG D   590                                                      
REMARK 465     LEU D   591                                                      
REMARK 465     ASP D   592                                                      
REMARK 465     ARG D   593                                                      
REMARK 465     ILE D   594                                                      
REMARK 465     GLY D   595                                                      
REMARK 465     LYS D   596                                                      
REMARK 465     LYS D   597                                                      
REMARK 465     ASN D   598                                                      
REMARK 465     SER D   599                                                      
REMARK 465     ILE D   600                                                      
REMARK 465     LEU D   601                                                      
REMARK 465     LEU D   602                                                      
REMARK 465     GLN D   603                                                      
REMARK 465     LYS D   604                                                      
REMARK 465     PHE D   605                                                      
REMARK 465     GLN D   606                                                      
REMARK 465     LYS D   607                                                      
REMARK 465     ASP D   608                                                      
REMARK 465     LEU D   609                                                      
REMARK 465     ASN D   610                                                      
REMARK 465     THR D   611                                                      
REMARK 465     GLY D   612                                                      
REMARK 465     VAL D   613                                                      
REMARK 465     PHE D   614                                                      
REMARK 465     ASN D   615                                                      
REMARK 465     ASN D   616                                                      
REMARK 465     GLN D   617                                                      
REMARK 465     GLU D   618                                                      
REMARK 465     ASN D   619                                                      
REMARK 465     GLU D   620                                                      
REMARK 465     ILE D   621                                                      
REMARK 465     LEU D   622                                                      
REMARK 465     LYS D   623                                                      
REMARK 465     GLN D   624                                                      
REMARK 465     ILE D   625                                                      
REMARK 465     VAL D   626                                                      
REMARK 465     LYS D   627                                                      
REMARK 465     HIS D   628                                                      
REMARK 465     ASP D   629                                                      
REMARK 465     ARG D   630                                                      
REMARK 465     GLU D   631                                                      
REMARK 465     MET D   632                                                      
REMARK 465     VAL D   633                                                      
REMARK 465     GLN D   634                                                      
REMARK 465     ALA D   635                                                      
REMARK 465     ALA D   636                                                      
REMARK 465     LEU D   637                                                      
REMARK 465     PRO D   638                                                      
REMARK 465     ARG D   639                                                      
REMARK 465     GLU D   640                                                      
REMARK 465     SER D   641                                                      
REMARK 465     SER D   642                                                      
REMARK 465     SER D   643                                                      
REMARK 465     VAL D   644                                                      
REMARK 465     LEU D   645                                                      
REMARK 465     ASN D   646                                                      
REMARK 465     THR D   647                                                      
REMARK 465     ASP D   648                                                      
REMARK 465     PRO D   649                                                      
REMARK 465     ASP D   650                                                      
REMARK 465     ALA D   651                                                      
REMARK 465     GLU D   652                                                      
REMARK 465     LYS D   653                                                      
REMARK 465     PRO D   654                                                      
REMARK 465     ARG D   655                                                      
REMARK 465     PHE D   656                                                      
REMARK 465     ALA D   657                                                      
REMARK 465     SER D   658                                                      
REMARK 465     ASN D   659                                                      
REMARK 465     LEU D   660                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     MET A  94    CG   SD   CE                                        
REMARK 470     ARG A  96    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE A  98    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER A 100    OG                                                  
REMARK 470     LEU A 102    CG   CD1  CD2                                       
REMARK 470     LEU A 111    CG   CD1  CD2                                       
REMARK 470     PHE A 132    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TRP A 133    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP A 133    CZ3  CH2                                            
REMARK 470     THR A 168    OG1  CG2                                            
REMARK 470     GLU A 169    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 170    CG   CD   OE1  NE2                                  
REMARK 470     THR A 171    OG1  CG2                                            
REMARK 470     THR A 173    OG1  CG2                                            
REMARK 470     ILE A 177    CG1  CG2  CD1                                       
REMARK 470     VAL A 180    CG1  CG2                                            
REMARK 470     ASP A 183    CG   OD1  OD2                                       
REMARK 470     ARG A 195    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR A 196    OG1  CG2                                            
REMARK 470     THR A 198    OG1  CG2                                            
REMARK 470     ASN A 200    CG   OD1  ND2                                       
REMARK 470     SER A 203    OG                                                  
REMARK 470     SER A 204    OG                                                  
REMARK 470     GLU A 205    CG   CD   OE1  OE2                                  
REMARK 470     ILE A 206    CG1  CG2  CD1                                       
REMARK 470     ILE A 207    CG1  CG2  CD1                                       
REMARK 470     LEU A 208    CG   CD1  CD2                                       
REMARK 470     ASP A 209    CG   OD1  OD2                                       
REMARK 470     LYS A 211    CG   CD   CE   NZ                                   
REMARK 470     VAL A 212    CG1  CG2                                            
REMARK 470     ILE A 213    CG1  CG2  CD1                                       
REMARK 470     LYS A 214    CG   CD   CE   NZ                                   
REMARK 470     MET A 215    CG   SD   CE                                        
REMARK 470     ASN A 216    CG   OD1  ND2                                       
REMARK 470     LEU A 218    CG   CD1  CD2                                       
REMARK 470     LYS A 219    CG   CD   CE   NZ                                   
REMARK 470     SER A 220    OG                                                  
REMARK 470     VAL A 224    CG1  CG2                                            
REMARK 470     GLU A 240    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 241    CG   CD   CE   NZ                                   
REMARK 470     ARG A 252    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A 254    CG   CD1  CD2                                       
REMARK 470     ARG A 255    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP A 324    CG   OD1  OD2                                       
REMARK 470     ASP A 328    CG   OD1  OD2                                       
REMARK 470     GLU A 335    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 339    CG   OD1  OD2                                       
REMARK 470     GLU A 447    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 455    CG   OD1  OD2                                       
REMARK 470     ARG A 467    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 468    CG   CD   CE   NZ                                   
REMARK 470     LEU A 469    CG   CD1  CD2                                       
REMARK 470     VAL A 470    CG1  CG2                                            
REMARK 470     THR A 472    OG1  CG2                                            
REMARK 470     MET A 473    CG   SD   CE                                        
REMARK 470     ASN A 478    CG   OD1  ND2                                       
REMARK 470     ASP A 480    CG   OD1  OD2                                       
REMARK 470     ASP A 500    CG   OD1  OD2                                       
REMARK 470     ILE A 503    CG1  CG2  CD1                                       
REMARK 470     GLU A 505    CG   CD   OE1  OE2                                  
REMARK 470     VAL A 508    CG1  CG2                                            
REMARK 470     LYS A 510    CG   CD   CE   NZ                                   
REMARK 470     VAL A 519    CG1  CG2                                            
REMARK 470     VAL A 522    CG1  CG2                                            
REMARK 470     ILE A 523    CG1  CG2  CD1                                       
REMARK 470     THR A 524    OG1  CG2                                            
REMARK 470     LYS A 525    CG   CD   CE   NZ                                   
REMARK 470     SER A 526    OG                                                  
REMARK 470     SER A 527    OG                                                  
REMARK 470     LYS A 528    CG   CD   CE   NZ                                   
REMARK 470     GLU A 529    CG   CD   OE1  OE2                                  
REMARK 470     MET A 530    CG   SD   CE                                        
REMARK 470     LYS A 531    CG   CD   CE   NZ                                   
REMARK 470     THR A 533    OG1  CG2                                            
REMARK 470     ASP A 534    CG   OD1  OD2                                       
REMARK 470     GLU A 540    CG   CD   OE1  OE2                                  
REMARK 470     ILE A 541    CG1  CG2  CD1                                       
REMARK 470     CYS A 542    SG                                                  
REMARK 470     LEU A 543    CG   CD1  CD2                                       
REMARK 470     LEU A 544    CG   CD1  CD2                                       
REMARK 470     THR A 545    OG1  CG2                                            
REMARK 470     LYS A 546    CG   CD   CE   NZ                                   
REMARK 470     ARG A 548    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 549    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR A 550    OG1  CG2                                            
REMARK 470     SER A 552    OG                                                  
REMARK 470     ASP A 556    CG   OD1  OD2                                       
REMARK 470     THR A 557    OG1  CG2                                            
REMARK 470     ASP A 567    CG   OD1  OD2                                       
REMARK 470     GLU A 571    CG   CD   OE1  OE2                                  
REMARK 470     VAL A 572    CG1  CG2                                            
REMARK 470     GLU A 574    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 575    CG   CD   OE1  OE2                                  
REMARK 470     MET A 578    CG   SD   CE                                        
REMARK 470     MET A 579    CG   SD   CE                                        
REMARK 470     ARG A 580    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 581    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE A 583    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU A 584    CG   CD   OE1  OE2                                  
REMARK 470     THR A 585    OG1  CG2                                            
REMARK 470     VAL A 586    CG1  CG2                                            
REMARK 470     MET B  94    CG   SD   CE                                        
REMARK 470     ARG B  96    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE B  98    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER B 100    OG                                                  
REMARK 470     LEU B 102    CG   CD1  CD2                                       
REMARK 470     LEU B 111    CG   CD1  CD2                                       
REMARK 470     PHE B 132    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TRP B 133    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP B 133    CZ3  CH2                                            
REMARK 470     THR B 168    OG1  CG2                                            
REMARK 470     GLU B 169    CG   CD   OE1  OE2                                  
REMARK 470     GLN B 170    CG   CD   OE1  NE2                                  
REMARK 470     THR B 171    OG1  CG2                                            
REMARK 470     THR B 173    OG1  CG2                                            
REMARK 470     ILE B 177    CG1  CG2  CD1                                       
REMARK 470     VAL B 180    CG1  CG2                                            
REMARK 470     ASP B 183    CG   OD1  OD2                                       
REMARK 470     ARG B 195    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR B 196    OG1  CG2                                            
REMARK 470     THR B 198    OG1  CG2                                            
REMARK 470     ASN B 200    CG   OD1  ND2                                       
REMARK 470     SER B 203    OG                                                  
REMARK 470     SER B 204    OG                                                  
REMARK 470     GLU B 205    CG   CD   OE1  OE2                                  
REMARK 470     ILE B 206    CG1  CG2  CD1                                       
REMARK 470     ILE B 207    CG1  CG2  CD1                                       
REMARK 470     LEU B 208    CG   CD1  CD2                                       
REMARK 470     ASP B 209    CG   OD1  OD2                                       
REMARK 470     LYS B 211    CG   CD   CE   NZ                                   
REMARK 470     VAL B 212    CG1  CG2                                            
REMARK 470     ILE B 213    CG1  CG2  CD1                                       
REMARK 470     LYS B 214    CG   CD   CE   NZ                                   
REMARK 470     MET B 215    CG   SD   CE                                        
REMARK 470     ASN B 216    CG   OD1  ND2                                       
REMARK 470     LEU B 218    CG   CD1  CD2                                       
REMARK 470     LYS B 219    CG   CD   CE   NZ                                   
REMARK 470     SER B 220    OG                                                  
REMARK 470     VAL B 224    CG1  CG2                                            
REMARK 470     GLU B 240    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 241    CG   CD   CE   NZ                                   
REMARK 470     ARG B 252    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU B 254    CG   CD1  CD2                                       
REMARK 470     ARG B 255    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B 324    CG   OD1  OD2                                       
REMARK 470     ASP B 328    CG   OD1  OD2                                       
REMARK 470     GLU B 335    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 339    CG   OD1  OD2                                       
REMARK 470     GLU B 447    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 455    CG   OD1  OD2                                       
REMARK 470     ARG B 467    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B 468    CG   CD   CE   NZ                                   
REMARK 470     LEU B 469    CG   CD1  CD2                                       
REMARK 470     VAL B 470    CG1  CG2                                            
REMARK 470     THR B 472    OG1  CG2                                            
REMARK 470     MET B 473    CG   SD   CE                                        
REMARK 470     ASN B 478    CG   OD1  ND2                                       
REMARK 470     ASP B 480    CG   OD1  OD2                                       
REMARK 470     ASP B 500    CG   OD1  OD2                                       
REMARK 470     ILE B 503    CG1  CG2  CD1                                       
REMARK 470     GLU B 505    CG   CD   OE1  OE2                                  
REMARK 470     VAL B 508    CG1  CG2                                            
REMARK 470     LYS B 510    CG   CD   CE   NZ                                   
REMARK 470     VAL B 519    CG1  CG2                                            
REMARK 470     VAL B 522    CG1  CG2                                            
REMARK 470     ILE B 523    CG1  CG2  CD1                                       
REMARK 470     THR B 524    OG1  CG2                                            
REMARK 470     LYS B 525    CG   CD   CE   NZ                                   
REMARK 470     SER B 526    OG                                                  
REMARK 470     SER B 527    OG                                                  
REMARK 470     LYS B 528    CG   CD   CE   NZ                                   
REMARK 470     GLU B 529    CG   CD   OE1  OE2                                  
REMARK 470     MET B 530    CG   SD   CE                                        
REMARK 470     LYS B 531    CG   CD   CE   NZ                                   
REMARK 470     THR B 533    OG1  CG2                                            
REMARK 470     ASP B 534    CG   OD1  OD2                                       
REMARK 470     GLU B 540    CG   CD   OE1  OE2                                  
REMARK 470     ILE B 541    CG1  CG2  CD1                                       
REMARK 470     CYS B 542    SG                                                  
REMARK 470     LEU B 543    CG   CD1  CD2                                       
REMARK 470     LEU B 544    CG   CD1  CD2                                       
REMARK 470     THR B 545    OG1  CG2                                            
REMARK 470     LYS B 546    CG   CD   CE   NZ                                   
REMARK 470     ARG B 548    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 549    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR B 550    OG1  CG2                                            
REMARK 470     SER B 552    OG                                                  
REMARK 470     ASP B 556    CG   OD1  OD2                                       
REMARK 470     THR B 557    OG1  CG2                                            
REMARK 470     ASP B 567    CG   OD1  OD2                                       
REMARK 470     GLU B 571    CG   CD   OE1  OE2                                  
REMARK 470     VAL B 572    CG1  CG2                                            
REMARK 470     GLU B 574    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 575    CG   CD   OE1  OE2                                  
REMARK 470     MET B 578    CG   SD   CE                                        
REMARK 470     MET B 579    CG   SD   CE                                        
REMARK 470     ARG B 580    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 581    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE B 583    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU B 584    CG   CD   OE1  OE2                                  
REMARK 470     THR B 585    OG1  CG2                                            
REMARK 470     VAL B 586    CG1  CG2                                            
REMARK 470     MET C  94    CG   SD   CE                                        
REMARK 470     ARG C  96    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE C  98    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER C 100    OG                                                  
REMARK 470     LEU C 102    CG   CD1  CD2                                       
REMARK 470     LEU C 111    CG   CD1  CD2                                       
REMARK 470     PHE C 132    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TRP C 133    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP C 133    CZ3  CH2                                            
REMARK 470     THR C 168    OG1  CG2                                            
REMARK 470     GLU C 169    CG   CD   OE1  OE2                                  
REMARK 470     GLN C 170    CG   CD   OE1  NE2                                  
REMARK 470     THR C 171    OG1  CG2                                            
REMARK 470     THR C 173    OG1  CG2                                            
REMARK 470     ILE C 177    CG1  CG2  CD1                                       
REMARK 470     VAL C 180    CG1  CG2                                            
REMARK 470     ASP C 183    CG   OD1  OD2                                       
REMARK 470     ARG C 195    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR C 196    OG1  CG2                                            
REMARK 470     THR C 198    OG1  CG2                                            
REMARK 470     ASN C 200    CG   OD1  ND2                                       
REMARK 470     SER C 203    OG                                                  
REMARK 470     SER C 204    OG                                                  
REMARK 470     GLU C 205    CG   CD   OE1  OE2                                  
REMARK 470     ILE C 206    CG1  CG2  CD1                                       
REMARK 470     ILE C 207    CG1  CG2  CD1                                       
REMARK 470     LEU C 208    CG   CD1  CD2                                       
REMARK 470     ASP C 209    CG   OD1  OD2                                       
REMARK 470     LYS C 211    CG   CD   CE   NZ                                   
REMARK 470     VAL C 212    CG1  CG2                                            
REMARK 470     ILE C 213    CG1  CG2  CD1                                       
REMARK 470     LYS C 214    CG   CD   CE   NZ                                   
REMARK 470     MET C 215    CG   SD   CE                                        
REMARK 470     ASN C 216    CG   OD1  ND2                                       
REMARK 470     LEU C 218    CG   CD1  CD2                                       
REMARK 470     LYS C 219    CG   CD   CE   NZ                                   
REMARK 470     SER C 220    OG                                                  
REMARK 470     VAL C 224    CG1  CG2                                            
REMARK 470     GLU C 240    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 241    CG   CD   CE   NZ                                   
REMARK 470     ARG C 252    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU C 254    CG   CD1  CD2                                       
REMARK 470     ARG C 255    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP C 324    CG   OD1  OD2                                       
REMARK 470     ASP C 328    CG   OD1  OD2                                       
REMARK 470     GLU C 335    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 339    CG   OD1  OD2                                       
REMARK 470     GLU C 447    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 455    CG   OD1  OD2                                       
REMARK 470     ARG C 467    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 468    CG   CD   CE   NZ                                   
REMARK 470     LEU C 469    CG   CD1  CD2                                       
REMARK 470     VAL C 470    CG1  CG2                                            
REMARK 470     THR C 472    OG1  CG2                                            
REMARK 470     MET C 473    CG   SD   CE                                        
REMARK 470     ASN C 478    CG   OD1  ND2                                       
REMARK 470     ASP C 480    CG   OD1  OD2                                       
REMARK 470     ASP C 500    CG   OD1  OD2                                       
REMARK 470     ILE C 503    CG1  CG2  CD1                                       
REMARK 470     GLU C 505    CG   CD   OE1  OE2                                  
REMARK 470     VAL C 508    CG1  CG2                                            
REMARK 470     LYS C 510    CG   CD   CE   NZ                                   
REMARK 470     VAL C 519    CG1  CG2                                            
REMARK 470     VAL C 522    CG1  CG2                                            
REMARK 470     ILE C 523    CG1  CG2  CD1                                       
REMARK 470     THR C 524    OG1  CG2                                            
REMARK 470     LYS C 525    CG   CD   CE   NZ                                   
REMARK 470     SER C 526    OG                                                  
REMARK 470     SER C 527    OG                                                  
REMARK 470     LYS C 528    CG   CD   CE   NZ                                   
REMARK 470     GLU C 529    CG   CD   OE1  OE2                                  
REMARK 470     MET C 530    CG   SD   CE                                        
REMARK 470     LYS C 531    CG   CD   CE   NZ                                   
REMARK 470     THR C 533    OG1  CG2                                            
REMARK 470     ASP C 534    CG   OD1  OD2                                       
REMARK 470     GLU C 540    CG   CD   OE1  OE2                                  
REMARK 470     ILE C 541    CG1  CG2  CD1                                       
REMARK 470     CYS C 542    SG                                                  
REMARK 470     LEU C 543    CG   CD1  CD2                                       
REMARK 470     LEU C 544    CG   CD1  CD2                                       
REMARK 470     THR C 545    OG1  CG2                                            
REMARK 470     LYS C 546    CG   CD   CE   NZ                                   
REMARK 470     ARG C 548    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C 549    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR C 550    OG1  CG2                                            
REMARK 470     SER C 552    OG                                                  
REMARK 470     ASP C 556    CG   OD1  OD2                                       
REMARK 470     THR C 557    OG1  CG2                                            
REMARK 470     ASP C 567    CG   OD1  OD2                                       
REMARK 470     GLU C 571    CG   CD   OE1  OE2                                  
REMARK 470     VAL C 572    CG1  CG2                                            
REMARK 470     GLU C 574    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 575    CG   CD   OE1  OE2                                  
REMARK 470     MET C 578    CG   SD   CE                                        
REMARK 470     MET C 579    CG   SD   CE                                        
REMARK 470     ARG C 580    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C 581    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE C 583    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU C 584    CG   CD   OE1  OE2                                  
REMARK 470     THR C 585    OG1  CG2                                            
REMARK 470     VAL C 586    CG1  CG2                                            
REMARK 470     MET D  94    CG   SD   CE                                        
REMARK 470     ARG D  96    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE D  98    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER D 100    OG                                                  
REMARK 470     LEU D 102    CG   CD1  CD2                                       
REMARK 470     LEU D 111    CG   CD1  CD2                                       
REMARK 470     PHE D 132    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TRP D 133    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP D 133    CZ3  CH2                                            
REMARK 470     THR D 168    OG1  CG2                                            
REMARK 470     GLU D 169    CG   CD   OE1  OE2                                  
REMARK 470     GLN D 170    CG   CD   OE1  NE2                                  
REMARK 470     THR D 171    OG1  CG2                                            
REMARK 470     THR D 173    OG1  CG2                                            
REMARK 470     ILE D 177    CG1  CG2  CD1                                       
REMARK 470     VAL D 180    CG1  CG2                                            
REMARK 470     ASP D 183    CG   OD1  OD2                                       
REMARK 470     ARG D 195    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR D 196    OG1  CG2                                            
REMARK 470     THR D 198    OG1  CG2                                            
REMARK 470     ASN D 200    CG   OD1  ND2                                       
REMARK 470     SER D 203    OG                                                  
REMARK 470     SER D 204    OG                                                  
REMARK 470     GLU D 205    CG   CD   OE1  OE2                                  
REMARK 470     ILE D 206    CG1  CG2  CD1                                       
REMARK 470     ILE D 207    CG1  CG2  CD1                                       
REMARK 470     LEU D 208    CG   CD1  CD2                                       
REMARK 470     ASP D 209    CG   OD1  OD2                                       
REMARK 470     LYS D 211    CG   CD   CE   NZ                                   
REMARK 470     VAL D 212    CG1  CG2                                            
REMARK 470     ILE D 213    CG1  CG2  CD1                                       
REMARK 470     LYS D 214    CG   CD   CE   NZ                                   
REMARK 470     MET D 215    CG   SD   CE                                        
REMARK 470     ASN D 216    CG   OD1  ND2                                       
REMARK 470     LEU D 218    CG   CD1  CD2                                       
REMARK 470     LYS D 219    CG   CD   CE   NZ                                   
REMARK 470     SER D 220    OG                                                  
REMARK 470     VAL D 224    CG1  CG2                                            
REMARK 470     GLU D 240    CG   CD   OE1  OE2                                  
REMARK 470     LYS D 241    CG   CD   CE   NZ                                   
REMARK 470     ARG D 252    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU D 254    CG   CD1  CD2                                       
REMARK 470     ARG D 255    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP D 324    CG   OD1  OD2                                       
REMARK 470     ASP D 328    CG   OD1  OD2                                       
REMARK 470     GLU D 335    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 339    CG   OD1  OD2                                       
REMARK 470     GLU D 447    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 455    CG   OD1  OD2                                       
REMARK 470     ARG D 467    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D 468    CG   CD   CE   NZ                                   
REMARK 470     LEU D 469    CG   CD1  CD2                                       
REMARK 470     VAL D 470    CG1  CG2                                            
REMARK 470     THR D 472    OG1  CG2                                            
REMARK 470     MET D 473    CG   SD   CE                                        
REMARK 470     ASN D 478    CG   OD1  ND2                                       
REMARK 470     ASP D 480    CG   OD1  OD2                                       
REMARK 470     ASP D 500    CG   OD1  OD2                                       
REMARK 470     ILE D 503    CG1  CG2  CD1                                       
REMARK 470     GLU D 505    CG   CD   OE1  OE2                                  
REMARK 470     VAL D 508    CG1  CG2                                            
REMARK 470     LYS D 510    CG   CD   CE   NZ                                   
REMARK 470     VAL D 519    CG1  CG2                                            
REMARK 470     VAL D 522    CG1  CG2                                            
REMARK 470     ILE D 523    CG1  CG2  CD1                                       
REMARK 470     THR D 524    OG1  CG2                                            
REMARK 470     LYS D 525    CG   CD   CE   NZ                                   
REMARK 470     SER D 526    OG                                                  
REMARK 470     SER D 527    OG                                                  
REMARK 470     LYS D 528    CG   CD   CE   NZ                                   
REMARK 470     GLU D 529    CG   CD   OE1  OE2                                  
REMARK 470     MET D 530    CG   SD   CE                                        
REMARK 470     LYS D 531    CG   CD   CE   NZ                                   
REMARK 470     THR D 533    OG1  CG2                                            
REMARK 470     ASP D 534    CG   OD1  OD2                                       
REMARK 470     GLU D 540    CG   CD   OE1  OE2                                  
REMARK 470     ILE D 541    CG1  CG2  CD1                                       
REMARK 470     CYS D 542    SG                                                  
REMARK 470     LEU D 543    CG   CD1  CD2                                       
REMARK 470     LEU D 544    CG   CD1  CD2                                       
REMARK 470     THR D 545    OG1  CG2                                            
REMARK 470     LYS D 546    CG   CD   CE   NZ                                   
REMARK 470     ARG D 548    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG D 549    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR D 550    OG1  CG2                                            
REMARK 470     SER D 552    OG                                                  
REMARK 470     ASP D 556    CG   OD1  OD2                                       
REMARK 470     THR D 557    OG1  CG2                                            
REMARK 470     ASP D 567    CG   OD1  OD2                                       
REMARK 470     GLU D 571    CG   CD   OE1  OE2                                  
REMARK 470     VAL D 572    CG1  CG2                                            
REMARK 470     GLU D 574    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 575    CG   CD   OE1  OE2                                  
REMARK 470     MET D 578    CG   SD   CE                                        
REMARK 470     MET D 579    CG   SD   CE                                        
REMARK 470     ARG D 580    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG D 581    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE D 583    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU D 584    CG   CD   OE1  OE2                                  
REMARK 470     THR D 585    OG1  CG2                                            
REMARK 470     VAL D 586    CG1  CG2                                            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS A 128        1.31    -62.06                                   
REMARK 500    ASP A 209      -70.91    -79.44                                   
REMARK 500    SER A 220      -74.83   -118.25                                   
REMARK 500    PHE A 325       71.38     52.16                                   
REMARK 500    ASP A 328       54.34   -107.91                                   
REMARK 500    LYS A 528     -119.56     65.73                                   
REMARK 500    LEU A 543      -62.72   -121.56                                   
REMARK 500    THR A 557     -167.68   -109.29                                   
REMARK 500    LYS B 128        1.37    -62.04                                   
REMARK 500    ASP B 209      -70.99    -79.31                                   
REMARK 500    SER B 220      -74.76   -118.25                                   
REMARK 500    PHE B 325       71.38     52.08                                   
REMARK 500    ASP B 328       54.33   -107.77                                   
REMARK 500    LYS B 528     -119.47     65.73                                   
REMARK 500    LEU B 543      -62.71   -121.56                                   
REMARK 500    THR B 557     -167.82   -109.65                                   
REMARK 500    LYS C 128        1.37    -62.11                                   
REMARK 500    ASP C 209      -70.81    -79.45                                   
REMARK 500    SER C 220      -74.90   -118.20                                   
REMARK 500    PHE C 325       71.38     52.17                                   
REMARK 500    ASP C 328       54.35   -107.89                                   
REMARK 500    LYS C 528     -119.55     65.76                                   
REMARK 500    LEU C 543      -62.73   -121.53                                   
REMARK 500    THR C 557     -167.69   -109.26                                   
REMARK 500    LYS D 128        1.31    -62.05                                   
REMARK 500    ASP D 209      -71.04    -79.31                                   
REMARK 500    SER D 220      -74.83   -118.25                                   
REMARK 500    PHE D 325       71.28     52.12                                   
REMARK 500    ASP D 328       54.29   -107.77                                   
REMARK 500    LYS D 528     -119.43     65.69                                   
REMARK 500    LEU D 543      -62.78   -121.52                                   
REMARK 500    THR D 557     -167.78   -109.53                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8511   RELATED DB: EMDB                              
REMARK 900 STRUCTURE OF THE HUMAN HCN1 HYPERPOLARIZATION-ACTIVATED CYCLIC       
REMARK 900 NUCLEOTIDE-GATED ION CHANNEL                                         
REMARK 900 RELATED ID: EMD-8512   RELATED DB: EMDB                              
REMARK 900 STRUCTURE OF THE HUMAN HCN1 HYPERPOLARIZATION-ACTIVATED CYCLIC       
REMARK 900 NUCLEOTIDE-GATED ION CHANNEL IN COMPLEX WITH CAMP                    
REMARK 900 RELATED ID: 5U6P   RELATED DB: PDB                                   
DBREF  5U6O A    1   635  UNP    O60741   HCN1_HUMAN       1    635             
DBREF  5U6O A  636   660  UNP    O60741   HCN1_HUMAN     866    890             
DBREF  5U6O B    1   635  UNP    O60741   HCN1_HUMAN       1    635             
DBREF  5U6O B  636   660  UNP    O60741   HCN1_HUMAN     866    890             
DBREF  5U6O C    1   635  UNP    O60741   HCN1_HUMAN       1    635             
DBREF  5U6O C  636   660  UNP    O60741   HCN1_HUMAN     866    890             
DBREF  5U6O D    1   635  UNP    O60741   HCN1_HUMAN       1    635             
DBREF  5U6O D  636   660  UNP    O60741   HCN1_HUMAN     866    890             
SEQRES   1 A  660  MET GLU GLY GLY GLY LYS PRO ASN SER SER SER ASN SER          
SEQRES   2 A  660  ARG ASP ASP GLY ASN SER VAL PHE PRO ALA LYS ALA SER          
SEQRES   3 A  660  ALA THR GLY ALA GLY PRO ALA ALA ALA GLU LYS ARG LEU          
SEQRES   4 A  660  GLY THR PRO PRO GLY GLY GLY GLY ALA GLY ALA LYS GLU          
SEQRES   5 A  660  HIS GLY ASN SER VAL CYS PHE LYS VAL ASP GLY GLY GLY          
SEQRES   6 A  660  GLY GLY GLY GLY GLY GLY GLY GLY GLY GLU GLU PRO ALA          
SEQRES   7 A  660  GLY GLY PHE GLU ASP ALA GLU GLY PRO ARG ARG GLN TYR          
SEQRES   8 A  660  GLY PHE MET GLN ARG GLN PHE THR SER MET LEU GLN PRO          
SEQRES   9 A  660  GLY VAL ASN LYS PHE SER LEU ARG MET PHE GLY SER GLN          
SEQRES  10 A  660  LYS ALA VAL GLU LYS GLU GLN GLU ARG VAL LYS THR ALA          
SEQRES  11 A  660  GLY PHE TRP ILE ILE HIS PRO TYR SER ASP PHE ARG PHE          
SEQRES  12 A  660  TYR TRP ASP LEU ILE MET LEU ILE MET MET VAL GLY ASN          
SEQRES  13 A  660  LEU VAL ILE ILE PRO VAL GLY ILE THR PHE PHE THR GLU          
SEQRES  14 A  660  GLN THR THR THR PRO TRP ILE ILE PHE ASN VAL ALA SER          
SEQRES  15 A  660  ASP THR VAL PHE LEU LEU ASP LEU ILE MET ASN PHE ARG          
SEQRES  16 A  660  THR GLY THR VAL ASN GLU ASP SER SER GLU ILE ILE LEU          
SEQRES  17 A  660  ASP PRO LYS VAL ILE LYS MET ASN TYR LEU LYS SER TRP          
SEQRES  18 A  660  PHE VAL VAL ASP PHE ILE SER SER ILE PRO VAL ASP TYR          
SEQRES  19 A  660  ILE PHE LEU ILE VAL GLU LYS GLY MET ASP SER GLU VAL          
SEQRES  20 A  660  TYR LYS THR ALA ARG ALA LEU ARG ILE VAL ARG PHE THR          
SEQRES  21 A  660  LYS ILE LEU SER LEU LEU ARG LEU LEU ARG LEU SER ARG          
SEQRES  22 A  660  LEU ILE ARG TYR ILE HIS GLN TRP GLU GLU ILE PHE HIS          
SEQRES  23 A  660  MET THR TYR ASP LEU ALA SER ALA VAL VAL ARG ILE PHE          
SEQRES  24 A  660  ASN LEU ILE GLY MET MET LEU LEU LEU CYS HIS TRP ASP          
SEQRES  25 A  660  GLY CYS LEU GLN PHE LEU VAL PRO LEU LEU GLN ASP PHE          
SEQRES  26 A  660  PRO PRO ASP CYS TRP VAL SER LEU ASN GLU MET VAL ASN          
SEQRES  27 A  660  ASP SER TRP GLY LYS GLN TYR SER TYR ALA LEU PHE LYS          
SEQRES  28 A  660  ALA MET SER HIS MET LEU CYS ILE GLY TYR GLY ALA GLN          
SEQRES  29 A  660  ALA PRO VAL SER MET SER ASP LEU TRP ILE THR MET LEU          
SEQRES  30 A  660  SER MET ILE VAL GLY ALA THR CYS TYR ALA MET PHE VAL          
SEQRES  31 A  660  GLY HIS ALA THR ALA LEU ILE GLN SER LEU ASP SER SER          
SEQRES  32 A  660  ARG ARG GLN TYR GLN GLU LYS TYR LYS GLN VAL GLU GLN          
SEQRES  33 A  660  TYR MET SER PHE HIS LYS LEU PRO ALA ASP MET ARG GLN          
SEQRES  34 A  660  LYS ILE HIS ASP TYR TYR GLU HIS ARG TYR GLN GLY LYS          
SEQRES  35 A  660  ILE PHE ASP GLU GLU ASN ILE LEU ASN GLU LEU ASN ASP          
SEQRES  36 A  660  PRO LEU ARG GLU GLU ILE VAL ASN PHE ASN CYS ARG LYS          
SEQRES  37 A  660  LEU VAL ALA THR MET PRO LEU PHE ALA ASN ALA ASP PRO          
SEQRES  38 A  660  ASN PHE VAL THR ALA MET LEU SER LYS LEU ARG PHE GLU          
SEQRES  39 A  660  VAL PHE GLN PRO GLY ASP TYR ILE ILE ARG GLU GLY ALA          
SEQRES  40 A  660  VAL GLY LYS LYS MET TYR PHE ILE GLN HIS GLY VAL ALA          
SEQRES  41 A  660  GLY VAL ILE THR LYS SER SER LYS GLU MET LYS LEU THR          
SEQRES  42 A  660  ASP GLY SER TYR PHE GLY GLU ILE CYS LEU LEU THR LYS          
SEQRES  43 A  660  GLY ARG ARG THR ALA SER VAL ARG ALA ASP THR TYR CYS          
SEQRES  44 A  660  ARG LEU TYR SER LEU SER VAL ASP ASN PHE ASN GLU VAL          
SEQRES  45 A  660  LEU GLU GLU TYR PRO MET MET ARG ARG ALA PHE GLU THR          
SEQRES  46 A  660  VAL ALA ILE ASP ARG LEU ASP ARG ILE GLY LYS LYS ASN          
SEQRES  47 A  660  SER ILE LEU LEU GLN LYS PHE GLN LYS ASP LEU ASN THR          
SEQRES  48 A  660  GLY VAL PHE ASN ASN GLN GLU ASN GLU ILE LEU LYS GLN          
SEQRES  49 A  660  ILE VAL LYS HIS ASP ARG GLU MET VAL GLN ALA ALA LEU          
SEQRES  50 A  660  PRO ARG GLU SER SER SER VAL LEU ASN THR ASP PRO ASP          
SEQRES  51 A  660  ALA GLU LYS PRO ARG PHE ALA SER ASN LEU                      
SEQRES   1 B  660  MET GLU GLY GLY GLY LYS PRO ASN SER SER SER ASN SER          
SEQRES   2 B  660  ARG ASP ASP GLY ASN SER VAL PHE PRO ALA LYS ALA SER          
SEQRES   3 B  660  ALA THR GLY ALA GLY PRO ALA ALA ALA GLU LYS ARG LEU          
SEQRES   4 B  660  GLY THR PRO PRO GLY GLY GLY GLY ALA GLY ALA LYS GLU          
SEQRES   5 B  660  HIS GLY ASN SER VAL CYS PHE LYS VAL ASP GLY GLY GLY          
SEQRES   6 B  660  GLY GLY GLY GLY GLY GLY GLY GLY GLY GLU GLU PRO ALA          
SEQRES   7 B  660  GLY GLY PHE GLU ASP ALA GLU GLY PRO ARG ARG GLN TYR          
SEQRES   8 B  660  GLY PHE MET GLN ARG GLN PHE THR SER MET LEU GLN PRO          
SEQRES   9 B  660  GLY VAL ASN LYS PHE SER LEU ARG MET PHE GLY SER GLN          
SEQRES  10 B  660  LYS ALA VAL GLU LYS GLU GLN GLU ARG VAL LYS THR ALA          
SEQRES  11 B  660  GLY PHE TRP ILE ILE HIS PRO TYR SER ASP PHE ARG PHE          
SEQRES  12 B  660  TYR TRP ASP LEU ILE MET LEU ILE MET MET VAL GLY ASN          
SEQRES  13 B  660  LEU VAL ILE ILE PRO VAL GLY ILE THR PHE PHE THR GLU          
SEQRES  14 B  660  GLN THR THR THR PRO TRP ILE ILE PHE ASN VAL ALA SER          
SEQRES  15 B  660  ASP THR VAL PHE LEU LEU ASP LEU ILE MET ASN PHE ARG          
SEQRES  16 B  660  THR GLY THR VAL ASN GLU ASP SER SER GLU ILE ILE LEU          
SEQRES  17 B  660  ASP PRO LYS VAL ILE LYS MET ASN TYR LEU LYS SER TRP          
SEQRES  18 B  660  PHE VAL VAL ASP PHE ILE SER SER ILE PRO VAL ASP TYR          
SEQRES  19 B  660  ILE PHE LEU ILE VAL GLU LYS GLY MET ASP SER GLU VAL          
SEQRES  20 B  660  TYR LYS THR ALA ARG ALA LEU ARG ILE VAL ARG PHE THR          
SEQRES  21 B  660  LYS ILE LEU SER LEU LEU ARG LEU LEU ARG LEU SER ARG          
SEQRES  22 B  660  LEU ILE ARG TYR ILE HIS GLN TRP GLU GLU ILE PHE HIS          
SEQRES  23 B  660  MET THR TYR ASP LEU ALA SER ALA VAL VAL ARG ILE PHE          
SEQRES  24 B  660  ASN LEU ILE GLY MET MET LEU LEU LEU CYS HIS TRP ASP          
SEQRES  25 B  660  GLY CYS LEU GLN PHE LEU VAL PRO LEU LEU GLN ASP PHE          
SEQRES  26 B  660  PRO PRO ASP CYS TRP VAL SER LEU ASN GLU MET VAL ASN          
SEQRES  27 B  660  ASP SER TRP GLY LYS GLN TYR SER TYR ALA LEU PHE LYS          
SEQRES  28 B  660  ALA MET SER HIS MET LEU CYS ILE GLY TYR GLY ALA GLN          
SEQRES  29 B  660  ALA PRO VAL SER MET SER ASP LEU TRP ILE THR MET LEU          
SEQRES  30 B  660  SER MET ILE VAL GLY ALA THR CYS TYR ALA MET PHE VAL          
SEQRES  31 B  660  GLY HIS ALA THR ALA LEU ILE GLN SER LEU ASP SER SER          
SEQRES  32 B  660  ARG ARG GLN TYR GLN GLU LYS TYR LYS GLN VAL GLU GLN          
SEQRES  33 B  660  TYR MET SER PHE HIS LYS LEU PRO ALA ASP MET ARG GLN          
SEQRES  34 B  660  LYS ILE HIS ASP TYR TYR GLU HIS ARG TYR GLN GLY LYS          
SEQRES  35 B  660  ILE PHE ASP GLU GLU ASN ILE LEU ASN GLU LEU ASN ASP          
SEQRES  36 B  660  PRO LEU ARG GLU GLU ILE VAL ASN PHE ASN CYS ARG LYS          
SEQRES  37 B  660  LEU VAL ALA THR MET PRO LEU PHE ALA ASN ALA ASP PRO          
SEQRES  38 B  660  ASN PHE VAL THR ALA MET LEU SER LYS LEU ARG PHE GLU          
SEQRES  39 B  660  VAL PHE GLN PRO GLY ASP TYR ILE ILE ARG GLU GLY ALA          
SEQRES  40 B  660  VAL GLY LYS LYS MET TYR PHE ILE GLN HIS GLY VAL ALA          
SEQRES  41 B  660  GLY VAL ILE THR LYS SER SER LYS GLU MET LYS LEU THR          
SEQRES  42 B  660  ASP GLY SER TYR PHE GLY GLU ILE CYS LEU LEU THR LYS          
SEQRES  43 B  660  GLY ARG ARG THR ALA SER VAL ARG ALA ASP THR TYR CYS          
SEQRES  44 B  660  ARG LEU TYR SER LEU SER VAL ASP ASN PHE ASN GLU VAL          
SEQRES  45 B  660  LEU GLU GLU TYR PRO MET MET ARG ARG ALA PHE GLU THR          
SEQRES  46 B  660  VAL ALA ILE ASP ARG LEU ASP ARG ILE GLY LYS LYS ASN          
SEQRES  47 B  660  SER ILE LEU LEU GLN LYS PHE GLN LYS ASP LEU ASN THR          
SEQRES  48 B  660  GLY VAL PHE ASN ASN GLN GLU ASN GLU ILE LEU LYS GLN          
SEQRES  49 B  660  ILE VAL LYS HIS ASP ARG GLU MET VAL GLN ALA ALA LEU          
SEQRES  50 B  660  PRO ARG GLU SER SER SER VAL LEU ASN THR ASP PRO ASP          
SEQRES  51 B  660  ALA GLU LYS PRO ARG PHE ALA SER ASN LEU                      
SEQRES   1 C  660  MET GLU GLY GLY GLY LYS PRO ASN SER SER SER ASN SER          
SEQRES   2 C  660  ARG ASP ASP GLY ASN SER VAL PHE PRO ALA LYS ALA SER          
SEQRES   3 C  660  ALA THR GLY ALA GLY PRO ALA ALA ALA GLU LYS ARG LEU          
SEQRES   4 C  660  GLY THR PRO PRO GLY GLY GLY GLY ALA GLY ALA LYS GLU          
SEQRES   5 C  660  HIS GLY ASN SER VAL CYS PHE LYS VAL ASP GLY GLY GLY          
SEQRES   6 C  660  GLY GLY GLY GLY GLY GLY GLY GLY GLY GLU GLU PRO ALA          
SEQRES   7 C  660  GLY GLY PHE GLU ASP ALA GLU GLY PRO ARG ARG GLN TYR          
SEQRES   8 C  660  GLY PHE MET GLN ARG GLN PHE THR SER MET LEU GLN PRO          
SEQRES   9 C  660  GLY VAL ASN LYS PHE SER LEU ARG MET PHE GLY SER GLN          
SEQRES  10 C  660  LYS ALA VAL GLU LYS GLU GLN GLU ARG VAL LYS THR ALA          
SEQRES  11 C  660  GLY PHE TRP ILE ILE HIS PRO TYR SER ASP PHE ARG PHE          
SEQRES  12 C  660  TYR TRP ASP LEU ILE MET LEU ILE MET MET VAL GLY ASN          
SEQRES  13 C  660  LEU VAL ILE ILE PRO VAL GLY ILE THR PHE PHE THR GLU          
SEQRES  14 C  660  GLN THR THR THR PRO TRP ILE ILE PHE ASN VAL ALA SER          
SEQRES  15 C  660  ASP THR VAL PHE LEU LEU ASP LEU ILE MET ASN PHE ARG          
SEQRES  16 C  660  THR GLY THR VAL ASN GLU ASP SER SER GLU ILE ILE LEU          
SEQRES  17 C  660  ASP PRO LYS VAL ILE LYS MET ASN TYR LEU LYS SER TRP          
SEQRES  18 C  660  PHE VAL VAL ASP PHE ILE SER SER ILE PRO VAL ASP TYR          
SEQRES  19 C  660  ILE PHE LEU ILE VAL GLU LYS GLY MET ASP SER GLU VAL          
SEQRES  20 C  660  TYR LYS THR ALA ARG ALA LEU ARG ILE VAL ARG PHE THR          
SEQRES  21 C  660  LYS ILE LEU SER LEU LEU ARG LEU LEU ARG LEU SER ARG          
SEQRES  22 C  660  LEU ILE ARG TYR ILE HIS GLN TRP GLU GLU ILE PHE HIS          
SEQRES  23 C  660  MET THR TYR ASP LEU ALA SER ALA VAL VAL ARG ILE PHE          
SEQRES  24 C  660  ASN LEU ILE GLY MET MET LEU LEU LEU CYS HIS TRP ASP          
SEQRES  25 C  660  GLY CYS LEU GLN PHE LEU VAL PRO LEU LEU GLN ASP PHE          
SEQRES  26 C  660  PRO PRO ASP CYS TRP VAL SER LEU ASN GLU MET VAL ASN          
SEQRES  27 C  660  ASP SER TRP GLY LYS GLN TYR SER TYR ALA LEU PHE LYS          
SEQRES  28 C  660  ALA MET SER HIS MET LEU CYS ILE GLY TYR GLY ALA GLN          
SEQRES  29 C  660  ALA PRO VAL SER MET SER ASP LEU TRP ILE THR MET LEU          
SEQRES  30 C  660  SER MET ILE VAL GLY ALA THR CYS TYR ALA MET PHE VAL          
SEQRES  31 C  660  GLY HIS ALA THR ALA LEU ILE GLN SER LEU ASP SER SER          
SEQRES  32 C  660  ARG ARG GLN TYR GLN GLU LYS TYR LYS GLN VAL GLU GLN          
SEQRES  33 C  660  TYR MET SER PHE HIS LYS LEU PRO ALA ASP MET ARG GLN          
SEQRES  34 C  660  LYS ILE HIS ASP TYR TYR GLU HIS ARG TYR GLN GLY LYS          
SEQRES  35 C  660  ILE PHE ASP GLU GLU ASN ILE LEU ASN GLU LEU ASN ASP          
SEQRES  36 C  660  PRO LEU ARG GLU GLU ILE VAL ASN PHE ASN CYS ARG LYS          
SEQRES  37 C  660  LEU VAL ALA THR MET PRO LEU PHE ALA ASN ALA ASP PRO          
SEQRES  38 C  660  ASN PHE VAL THR ALA MET LEU SER LYS LEU ARG PHE GLU          
SEQRES  39 C  660  VAL PHE GLN PRO GLY ASP TYR ILE ILE ARG GLU GLY ALA          
SEQRES  40 C  660  VAL GLY LYS LYS MET TYR PHE ILE GLN HIS GLY VAL ALA          
SEQRES  41 C  660  GLY VAL ILE THR LYS SER SER LYS GLU MET LYS LEU THR          
SEQRES  42 C  660  ASP GLY SER TYR PHE GLY GLU ILE CYS LEU LEU THR LYS          
SEQRES  43 C  660  GLY ARG ARG THR ALA SER VAL ARG ALA ASP THR TYR CYS          
SEQRES  44 C  660  ARG LEU TYR SER LEU SER VAL ASP ASN PHE ASN GLU VAL          
SEQRES  45 C  660  LEU GLU GLU TYR PRO MET MET ARG ARG ALA PHE GLU THR          
SEQRES  46 C  660  VAL ALA ILE ASP ARG LEU ASP ARG ILE GLY LYS LYS ASN          
SEQRES  47 C  660  SER ILE LEU LEU GLN LYS PHE GLN LYS ASP LEU ASN THR          
SEQRES  48 C  660  GLY VAL PHE ASN ASN GLN GLU ASN GLU ILE LEU LYS GLN          
SEQRES  49 C  660  ILE VAL LYS HIS ASP ARG GLU MET VAL GLN ALA ALA LEU          
SEQRES  50 C  660  PRO ARG GLU SER SER SER VAL LEU ASN THR ASP PRO ASP          
SEQRES  51 C  660  ALA GLU LYS PRO ARG PHE ALA SER ASN LEU                      
SEQRES   1 D  660  MET GLU GLY GLY GLY LYS PRO ASN SER SER SER ASN SER          
SEQRES   2 D  660  ARG ASP ASP GLY ASN SER VAL PHE PRO ALA LYS ALA SER          
SEQRES   3 D  660  ALA THR GLY ALA GLY PRO ALA ALA ALA GLU LYS ARG LEU          
SEQRES   4 D  660  GLY THR PRO PRO GLY GLY GLY GLY ALA GLY ALA LYS GLU          
SEQRES   5 D  660  HIS GLY ASN SER VAL CYS PHE LYS VAL ASP GLY GLY GLY          
SEQRES   6 D  660  GLY GLY GLY GLY GLY GLY GLY GLY GLY GLU GLU PRO ALA          
SEQRES   7 D  660  GLY GLY PHE GLU ASP ALA GLU GLY PRO ARG ARG GLN TYR          
SEQRES   8 D  660  GLY PHE MET GLN ARG GLN PHE THR SER MET LEU GLN PRO          
SEQRES   9 D  660  GLY VAL ASN LYS PHE SER LEU ARG MET PHE GLY SER GLN          
SEQRES  10 D  660  LYS ALA VAL GLU LYS GLU GLN GLU ARG VAL LYS THR ALA          
SEQRES  11 D  660  GLY PHE TRP ILE ILE HIS PRO TYR SER ASP PHE ARG PHE          
SEQRES  12 D  660  TYR TRP ASP LEU ILE MET LEU ILE MET MET VAL GLY ASN          
SEQRES  13 D  660  LEU VAL ILE ILE PRO VAL GLY ILE THR PHE PHE THR GLU          
SEQRES  14 D  660  GLN THR THR THR PRO TRP ILE ILE PHE ASN VAL ALA SER          
SEQRES  15 D  660  ASP THR VAL PHE LEU LEU ASP LEU ILE MET ASN PHE ARG          
SEQRES  16 D  660  THR GLY THR VAL ASN GLU ASP SER SER GLU ILE ILE LEU          
SEQRES  17 D  660  ASP PRO LYS VAL ILE LYS MET ASN TYR LEU LYS SER TRP          
SEQRES  18 D  660  PHE VAL VAL ASP PHE ILE SER SER ILE PRO VAL ASP TYR          
SEQRES  19 D  660  ILE PHE LEU ILE VAL GLU LYS GLY MET ASP SER GLU VAL          
SEQRES  20 D  660  TYR LYS THR ALA ARG ALA LEU ARG ILE VAL ARG PHE THR          
SEQRES  21 D  660  LYS ILE LEU SER LEU LEU ARG LEU LEU ARG LEU SER ARG          
SEQRES  22 D  660  LEU ILE ARG TYR ILE HIS GLN TRP GLU GLU ILE PHE HIS          
SEQRES  23 D  660  MET THR TYR ASP LEU ALA SER ALA VAL VAL ARG ILE PHE          
SEQRES  24 D  660  ASN LEU ILE GLY MET MET LEU LEU LEU CYS HIS TRP ASP          
SEQRES  25 D  660  GLY CYS LEU GLN PHE LEU VAL PRO LEU LEU GLN ASP PHE          
SEQRES  26 D  660  PRO PRO ASP CYS TRP VAL SER LEU ASN GLU MET VAL ASN          
SEQRES  27 D  660  ASP SER TRP GLY LYS GLN TYR SER TYR ALA LEU PHE LYS          
SEQRES  28 D  660  ALA MET SER HIS MET LEU CYS ILE GLY TYR GLY ALA GLN          
SEQRES  29 D  660  ALA PRO VAL SER MET SER ASP LEU TRP ILE THR MET LEU          
SEQRES  30 D  660  SER MET ILE VAL GLY ALA THR CYS TYR ALA MET PHE VAL          
SEQRES  31 D  660  GLY HIS ALA THR ALA LEU ILE GLN SER LEU ASP SER SER          
SEQRES  32 D  660  ARG ARG GLN TYR GLN GLU LYS TYR LYS GLN VAL GLU GLN          
SEQRES  33 D  660  TYR MET SER PHE HIS LYS LEU PRO ALA ASP MET ARG GLN          
SEQRES  34 D  660  LYS ILE HIS ASP TYR TYR GLU HIS ARG TYR GLN GLY LYS          
SEQRES  35 D  660  ILE PHE ASP GLU GLU ASN ILE LEU ASN GLU LEU ASN ASP          
SEQRES  36 D  660  PRO LEU ARG GLU GLU ILE VAL ASN PHE ASN CYS ARG LYS          
SEQRES  37 D  660  LEU VAL ALA THR MET PRO LEU PHE ALA ASN ALA ASP PRO          
SEQRES  38 D  660  ASN PHE VAL THR ALA MET LEU SER LYS LEU ARG PHE GLU          
SEQRES  39 D  660  VAL PHE GLN PRO GLY ASP TYR ILE ILE ARG GLU GLY ALA          
SEQRES  40 D  660  VAL GLY LYS LYS MET TYR PHE ILE GLN HIS GLY VAL ALA          
SEQRES  41 D  660  GLY VAL ILE THR LYS SER SER LYS GLU MET LYS LEU THR          
SEQRES  42 D  660  ASP GLY SER TYR PHE GLY GLU ILE CYS LEU LEU THR LYS          
SEQRES  43 D  660  GLY ARG ARG THR ALA SER VAL ARG ALA ASP THR TYR CYS          
SEQRES  44 D  660  ARG LEU TYR SER LEU SER VAL ASP ASN PHE ASN GLU VAL          
SEQRES  45 D  660  LEU GLU GLU TYR PRO MET MET ARG ARG ALA PHE GLU THR          
SEQRES  46 D  660  VAL ALA ILE ASP ARG LEU ASP ARG ILE GLY LYS LYS ASN          
SEQRES  47 D  660  SER ILE LEU LEU GLN LYS PHE GLN LYS ASP LEU ASN THR          
SEQRES  48 D  660  GLY VAL PHE ASN ASN GLN GLU ASN GLU ILE LEU LYS GLN          
SEQRES  49 D  660  ILE VAL LYS HIS ASP ARG GLU MET VAL GLN ALA ALA LEU          
SEQRES  50 D  660  PRO ARG GLU SER SER SER VAL LEU ASN THR ASP PRO ASP          
SEQRES  51 D  660  ALA GLU LYS PRO ARG PHE ALA SER ASN LEU                      
HELIX    1 AA1 MET A   94  GLN A  103  1                                  10    
HELIX    2 AA2 ASN A  107  GLY A  115  1                                   9    
HELIX    3 AA3 SER A  116  LYS A  128  1                                  13    
HELIX    4 AA4 SER A  139  PHE A  167  1                                  29    
HELIX    5 AA5 THR A  172  THR A  196  1                                  25    
HELIX    6 AA6 LYS A  211  LYS A  219  1                                   9    
HELIX    7 AA7 TRP A  221  ILE A  230  1                                  10    
HELIX    8 AA8 PRO A  231  GLY A  242  1                                  12    
HELIX    9 AA9 ALA A  253  LEU A  265  1                                  13    
HELIX   10 AB1 LEU A  266  LEU A  268  5                                   3    
HELIX   11 AB2 LEU A  269  ASP A  290  1                                  22    
HELIX   12 AB3 ALA A  292  GLN A  323  1                                  32    
HELIX   13 AB4 CYS A  329  ASN A  334  1                                   6    
HELIX   14 AB5 SER A  340  CYS A  358  1                                  19    
HELIX   15 AB6 SER A  368  ASP A  401  1                                  34    
HELIX   16 AB7 ASP A  401  LYS A  422  1                                  22    
HELIX   17 AB8 PRO A  424  GLN A  440  1                                  17    
HELIX   18 AB9 ASP A  445  LEU A  453  1                                   9    
HELIX   19 AC1 ASN A  454  MET A  473  1                                  20    
HELIX   20 AC2 ASP A  480  LEU A  491  1                                  12    
HELIX   21 AC3 VAL A  566  TYR A  576  1                                  11    
HELIX   22 AC4 TYR A  576  THR A  585  1                                  10    
HELIX   23 AC5 GLN B   95  GLN B  103  1                                   9    
HELIX   24 AC6 ASN B  107  GLY B  115  1                                   9    
HELIX   25 AC7 SER B  116  LYS B  128  1                                  13    
HELIX   26 AC8 SER B  139  PHE B  167  1                                  29    
HELIX   27 AC9 THR B  172  THR B  196  1                                  25    
HELIX   28 AD1 LYS B  211  LYS B  219  1                                   9    
HELIX   29 AD2 TRP B  221  ILE B  230  1                                  10    
HELIX   30 AD3 PRO B  231  GLY B  242  1                                  12    
HELIX   31 AD4 ALA B  253  LEU B  265  1                                  13    
HELIX   32 AD5 LEU B  266  LEU B  268  5                                   3    
HELIX   33 AD6 LEU B  269  ASP B  290  1                                  22    
HELIX   34 AD7 ALA B  292  GLN B  323  1                                  32    
HELIX   35 AD8 CYS B  329  ASN B  334  1                                   6    
HELIX   36 AD9 SER B  340  CYS B  358  1                                  19    
HELIX   37 AE1 SER B  368  ASP B  401  1                                  34    
HELIX   38 AE2 ASP B  401  LYS B  422  1                                  22    
HELIX   39 AE3 PRO B  424  GLN B  440  1                                  17    
HELIX   40 AE4 ASP B  445  LEU B  453  1                                   9    
HELIX   41 AE5 ASN B  454  MET B  473  1                                  20    
HELIX   42 AE6 ASP B  480  LEU B  491  1                                  12    
HELIX   43 AE7 VAL B  566  TYR B  576  1                                  11    
HELIX   44 AE8 TYR B  576  THR B  585  1                                  10    
HELIX   45 AE9 GLN C   95  GLN C  103  1                                   9    
HELIX   46 AF1 ASN C  107  GLY C  115  1                                   9    
HELIX   47 AF2 SER C  116  LYS C  128  1                                  13    
HELIX   48 AF3 SER C  139  PHE C  167  1                                  29    
HELIX   49 AF4 THR C  172  THR C  196  1                                  25    
HELIX   50 AF5 LYS C  211  LYS C  219  1                                   9    
HELIX   51 AF6 TRP C  221  ILE C  230  1                                  10    
HELIX   52 AF7 PRO C  231  GLY C  242  1                                  12    
HELIX   53 AF8 ALA C  253  LEU C  265  1                                  13    
HELIX   54 AF9 LEU C  266  LEU C  268  5                                   3    
HELIX   55 AG1 LEU C  269  ASP C  290  1                                  22    
HELIX   56 AG2 ALA C  292  GLN C  323  1                                  32    
HELIX   57 AG3 CYS C  329  ASN C  334  1                                   6    
HELIX   58 AG4 SER C  340  CYS C  358  1                                  19    
HELIX   59 AG5 SER C  368  ASP C  401  1                                  34    
HELIX   60 AG6 ASP C  401  LYS C  422  1                                  22    
HELIX   61 AG7 PRO C  424  GLN C  440  1                                  17    
HELIX   62 AG8 ASP C  445  LEU C  453  1                                   9    
HELIX   63 AG9 ASN C  454  MET C  473  1                                  20    
HELIX   64 AH1 ASP C  480  LEU C  491  1                                  12    
HELIX   65 AH2 VAL C  566  TYR C  576  1                                  11    
HELIX   66 AH3 TYR C  576  THR C  585  1                                  10    
HELIX   67 AH4 GLN D   95  GLN D  103  1                                   9    
HELIX   68 AH5 ASN D  107  GLY D  115  1                                   9    
HELIX   69 AH6 SER D  116  LYS D  128  1                                  13    
HELIX   70 AH7 SER D  139  PHE D  167  1                                  29    
HELIX   71 AH8 THR D  172  THR D  196  1                                  25    
HELIX   72 AH9 LYS D  211  LYS D  219  1                                   9    
HELIX   73 AI1 TRP D  221  ILE D  230  1                                  10    
HELIX   74 AI2 PRO D  231  GLY D  242  1                                  12    
HELIX   75 AI3 ALA D  253  LEU D  265  1                                  13    
HELIX   76 AI4 LEU D  266  LEU D  268  5                                   3    
HELIX   77 AI5 LEU D  269  ASP D  290  1                                  22    
HELIX   78 AI6 ALA D  292  GLN D  323  1                                  32    
HELIX   79 AI7 CYS D  329  ASN D  334  1                                   6    
HELIX   80 AI8 SER D  340  CYS D  358  1                                  19    
HELIX   81 AI9 SER D  368  ASP D  401  1                                  34    
HELIX   82 AJ1 ASP D  401  LYS D  422  1                                  22    
HELIX   83 AJ2 PRO D  424  GLN D  440  1                                  17    
HELIX   84 AJ3 ASP D  445  LEU D  453  1                                   9    
HELIX   85 AJ4 ASN D  454  MET D  473  1                                  20    
HELIX   86 AJ5 ASP D  480  LEU D  491  1                                  12    
HELIX   87 AJ6 VAL D  566  TYR D  576  1                                  11    
HELIX   88 AJ7 TYR D  576  THR D  585  1                                  10    
SHEET    1 AA1 4 ARG A 492  PHE A 496  0                                        
SHEET    2 AA1 4 SER A 552  SER A 565 -1  O  SER A 563   N  ARG A 492           
SHEET    3 AA1 4 LYS A 511  ILE A 523 -1  N  MET A 512   O  LEU A 564           
SHEET    4 AA1 4 GLU A 529  MET A 530 -1  O  MET A 530   N  VAL A 522           
SHEET    1 AA2 4 TYR A 501  ILE A 503  0                                        
SHEET    2 AA2 4 SER A 552  SER A 565 -1  O  VAL A 553   N  ILE A 503           
SHEET    3 AA2 4 LYS A 511  ILE A 523 -1  N  MET A 512   O  LEU A 564           
SHEET    4 AA2 4 TYR A 537  PHE A 538 -1  O  PHE A 538   N  TYR A 513           
SHEET    1 AA3 4 ARG B 492  PHE B 496  0                                        
SHEET    2 AA3 4 SER B 552  SER B 565 -1  O  SER B 563   N  ARG B 492           
SHEET    3 AA3 4 LYS B 511  ILE B 523 -1  N  MET B 512   O  LEU B 564           
SHEET    4 AA3 4 GLU B 529  MET B 530 -1  O  MET B 530   N  VAL B 522           
SHEET    1 AA4 4 TYR B 501  ILE B 503  0                                        
SHEET    2 AA4 4 SER B 552  SER B 565 -1  O  VAL B 553   N  ILE B 503           
SHEET    3 AA4 4 LYS B 511  ILE B 523 -1  N  MET B 512   O  LEU B 564           
SHEET    4 AA4 4 TYR B 537  PHE B 538 -1  O  PHE B 538   N  TYR B 513           
SHEET    1 AA5 4 ARG C 492  PHE C 496  0                                        
SHEET    2 AA5 4 SER C 552  SER C 565 -1  O  SER C 563   N  ARG C 492           
SHEET    3 AA5 4 LYS C 511  ILE C 523 -1  N  MET C 512   O  LEU C 564           
SHEET    4 AA5 4 GLU C 529  MET C 530 -1  O  MET C 530   N  VAL C 522           
SHEET    1 AA6 4 TYR C 501  ILE C 503  0                                        
SHEET    2 AA6 4 SER C 552  SER C 565 -1  O  VAL C 553   N  ILE C 503           
SHEET    3 AA6 4 LYS C 511  ILE C 523 -1  N  MET C 512   O  LEU C 564           
SHEET    4 AA6 4 TYR C 537  PHE C 538 -1  O  PHE C 538   N  TYR C 513           
SHEET    1 AA7 4 ARG D 492  PHE D 496  0                                        
SHEET    2 AA7 4 SER D 552  SER D 565 -1  O  SER D 563   N  ARG D 492           
SHEET    3 AA7 4 LYS D 511  ILE D 523 -1  N  MET D 512   O  LEU D 564           
SHEET    4 AA7 4 GLU D 529  MET D 530 -1  O  MET D 530   N  VAL D 522           
SHEET    1 AA8 4 TYR D 501  ILE D 503  0                                        
SHEET    2 AA8 4 SER D 552  SER D 565 -1  O  VAL D 553   N  ILE D 503           
SHEET    3 AA8 4 LYS D 511  ILE D 523 -1  N  MET D 512   O  LEU D 564           
SHEET    4 AA8 4 TYR D 537  PHE D 538 -1  O  PHE D 538   N  TYR D 513           
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
MTRIX1   1  1.000000  0.000000  0.000000        0.00000    1                    
MTRIX2   1  0.000000  1.000000  0.000000        0.00000    1                    
MTRIX3   1  0.000000  0.000000  1.000000        0.00000    1                    
MTRIX1   2  0.001246  0.999999  0.000332       -0.09105    1                    
MTRIX2   2 -0.999999  0.001246  0.000723      124.71944    1                    
MTRIX3   2  0.000723 -0.000332  1.000000       -0.01601    1                    
MTRIX1   3 -0.999999  0.001310  0.000614      124.73636    1                    
MTRIX2   3 -0.001310 -0.999999  0.000725      124.87591    1                    
MTRIX3   3  0.000615  0.000724  1.000000       -0.07010    1                    
MTRIX1   4  0.000198 -1.000000  0.000119      124.81739    1                    
MTRIX2   4  1.000000  0.000198 -0.000115       -0.01223    1                    
MTRIX3   4  0.000115  0.000119  1.000000       -0.01129    1                    
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system