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Database: PDB
Entry: 5U7G
LinkDB: 5U7G
Original site: 5U7G 
HEADER    TRANSFERASE                             12-DEC-16   5U7G              
TITLE     CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF CBP                        
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: CREB-BINDING PROTEIN;                                      
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 FRAGMENT: UNP RESIDUES 1073-1550;                                    
COMPND   5 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE   3 ORGANISM_COMMON: MOUSE;                                              
SOURCE   4 ORGANISM_TAXID: 10090;                                               
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    HISTONE ACETYLTRANSFERASE, BROMODOMAIN, ZINC FINGERS, TRANSCRIPTIONAL 
KEYWDS   2 COACTIVATOR, TRANSFERASE                                             
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    S.PARK,R.L.STANFIELD,M.M.MARTINEZ-YAMOUT,H.J.DYSON,I.A.WILSON,        
AUTHOR   2 P.E.WRIGHT                                                           
REVDAT   4   27-SEP-17 5U7G    1       REMARK                                   
REVDAT   3   12-JUL-17 5U7G    1       JRNL                                     
REVDAT   2   05-JUL-17 5U7G    1       JRNL                                     
REVDAT   1   21-JUN-17 5U7G    0                                                
JRNL        AUTH   S.PARK,R.L.STANFIELD,M.A.MARTINEZ-YAMOUT,H.J.DYSON,          
JRNL        AUTH 2 I.A.WILSON,P.E.WRIGHT                                        
JRNL        TITL   ROLE OF THE CBP CATALYTIC CORE IN INTRAMOLECULAR SUMOYLATION 
JRNL        TITL 2 AND CONTROL OF HISTONE H3 ACETYLATION.                       
JRNL        REF    PROC. NATL. ACAD. SCI.        V. 114 E5335 2017              
JRNL        REF  2 U.S.A.                                                       
JRNL        REFN                   ESSN 1091-6490                               
JRNL        PMID   28630323                                                     
JRNL        DOI    10.1073/PNAS.1703105114                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.40 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (1.10_2155: ???)                              
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.40                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.90                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.3                           
REMARK   3   NUMBER OF REFLECTIONS             : 77429                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.256                           
REMARK   3   R VALUE            (WORKING SET) : 0.254                           
REMARK   3   FREE R VALUE                     : 0.283                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.020                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 3886                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 47.9131 -  7.2838    0.98     2706   138  0.2163 0.2283        
REMARK   3     2  7.2838 -  5.7845    0.99     2647   164  0.2233 0.2761        
REMARK   3     3  5.7845 -  5.0542    1.00     2663   143  0.2015 0.2203        
REMARK   3     4  5.0542 -  4.5925    1.00     2665   136  0.1930 0.2241        
REMARK   3     5  4.5925 -  4.2636    1.00     2654   143  0.1953 0.2074        
REMARK   3     6  4.2636 -  4.0123    1.00     2663   137  0.2052 0.2298        
REMARK   3     7  4.0123 -  3.8115    1.00     2658   122  0.2260 0.2677        
REMARK   3     8  3.8115 -  3.6456    1.00     2634   150  0.2343 0.2714        
REMARK   3     9  3.6456 -  3.5053    1.00     2618   149  0.2502 0.3146        
REMARK   3    10  3.5053 -  3.3844    1.00     2669   130  0.2644 0.3047        
REMARK   3    11  3.3844 -  3.2786    1.00     2631   144  0.2964 0.2922        
REMARK   3    12  3.2786 -  3.1849    1.00     2657   127  0.3033 0.3423        
REMARK   3    13  3.1849 -  3.1011    1.00     2605   150  0.2997 0.3234        
REMARK   3    14  3.1011 -  3.0254    1.00     2634   143  0.3011 0.3490        
REMARK   3    15  3.0254 -  2.9567    1.00     2619   149  0.3040 0.3230        
REMARK   3    16  2.9567 -  2.8938    0.99     2602   146  0.3018 0.3141        
REMARK   3    17  2.8938 -  2.8359    1.00     2643   149  0.3229 0.3396        
REMARK   3    18  2.8359 -  2.7824    1.00     2627   129  0.3248 0.3599        
REMARK   3    19  2.7824 -  2.7327    1.00     2634   136  0.3263 0.3756        
REMARK   3    20  2.7327 -  2.6864    1.00     2653   130  0.3160 0.3375        
REMARK   3    21  2.6864 -  2.6430    1.00     2632   125  0.3180 0.3293        
REMARK   3    22  2.6430 -  2.6024    1.00     2642   123  0.3173 0.3624        
REMARK   3    23  2.6024 -  2.5641    1.00     2611   137  0.3225 0.3688        
REMARK   3    24  2.5641 -  2.5280    1.00     2645   137  0.3320 0.3580        
REMARK   3    25  2.5280 -  2.4938    1.00     2614   157  0.3359 0.3551        
REMARK   3    26  2.4938 -  2.4614    0.98     2567   142  0.3356 0.3812        
REMARK   3    27  2.4614 -  2.4307    0.98     2600   131  0.3482 0.3669        
REMARK   3    28  2.4307 -  2.4014    0.90     2350   119  0.3733 0.3992        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.380            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 33.890           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.013           9140                                  
REMARK   3   ANGLE     :  1.067          12348                                  
REMARK   3   CHIRALITY :  0.057           1290                                  
REMARK   3   PLANARITY :  0.008           1600                                  
REMARK   3   DIHEDRAL  : 12.341           5438                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 5U7G COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-DEC-16.                  
REMARK 100 THE DEPOSITION ID IS D_1000225444.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 25-OCT-14                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 23-ID-D                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.03320                            
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M                 
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 77429                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.400                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8                               
REMARK 200  DATA REDUNDANCY                : 5.000                              
REMARK 200  R MERGE                    (I) : 0.11200                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 12.7000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 4BHW                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 64.66                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.48                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: PEG 3350, TRI-SODIUM CITRATE, VAPOR      
REMARK 280  DIFFUSION, SITTING DROP, TEMPERATURE 293K                           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y,-Z                                                 
REMARK 290       3555   X+1/2,Y+1/2,Z                                           
REMARK 290       4555   -X+1/2,Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000      107.08650            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       43.58500            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000      107.08650            
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       43.58500            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: MONOMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     THR A  1211                                                      
REMARK 465     LEU A  1212                                                      
REMARK 465     CYS A  1213                                                      
REMARK 465     CYS A  1214                                                      
REMARK 465     TYR A  1215                                                      
REMARK 465     GLY A  1216                                                      
REMARK 465     LYS A  1217                                                      
REMARK 465     GLN A  1218                                                      
REMARK 465     LEU A  1219                                                      
REMARK 465     CYS A  1220                                                      
REMARK 465     THR A  1221                                                      
REMARK 465     ILE A  1222                                                      
REMARK 465     PRO A  1223                                                      
REMARK 465     ARG A  1224                                                      
REMARK 465     ASP A  1225                                                      
REMARK 465     ALA A  1226                                                      
REMARK 465     ALA A  1227                                                      
REMARK 465     TYR A  1228                                                      
REMARK 465     TYR A  1229                                                      
REMARK 465     SER A  1230                                                      
REMARK 465     TYR A  1231                                                      
REMARK 465     GLN A  1232                                                      
REMARK 465     ASN A  1233                                                      
REMARK 465     ARG A  1234                                                      
REMARK 465     TYR A  1235                                                      
REMARK 465     HIS A  1236                                                      
REMARK 465     PHE A  1237                                                      
REMARK 465     CYS A  1238                                                      
REMARK 465     GLU A  1239                                                      
REMARK 465     LYS A  1240                                                      
REMARK 465     CYS A  1241                                                      
REMARK 465     PHE A  1242                                                      
REMARK 465     THR A  1243                                                      
REMARK 465     GLU A  1244                                                      
REMARK 465     ILE A  1245                                                      
REMARK 465     GLN A  1246                                                      
REMARK 465     GLY A  1247                                                      
REMARK 465     GLU A  1248                                                      
REMARK 465     ASN A  1249                                                      
REMARK 465     VAL A  1250                                                      
REMARK 465     THR A  1251                                                      
REMARK 465     LEU A  1252                                                      
REMARK 465     GLY A  1253                                                      
REMARK 465     ASP A  1254                                                      
REMARK 465     ASP A  1255                                                      
REMARK 465     PRO A  1256                                                      
REMARK 465     SER A  1257                                                      
REMARK 465     GLN A  1258                                                      
REMARK 465     PRO A  1259                                                      
REMARK 465     GLN A  1260                                                      
REMARK 465     THR A  1261                                                      
REMARK 465     THR A  1262                                                      
REMARK 465     ILE A  1263                                                      
REMARK 465     SER A  1264                                                      
REMARK 465     LYS A  1265                                                      
REMARK 465     ASP A  1266                                                      
REMARK 465     GLN A  1267                                                      
REMARK 465     PHE A  1268                                                      
REMARK 465     GLU A  1269                                                      
REMARK 465     LYS A  1270                                                      
REMARK 465     LYS A  1271                                                      
REMARK 465     LYS A  1272                                                      
REMARK 465     GLY A  1616                                                      
REMARK 465     SER A  1617                                                      
REMARK 465     GLY A  1618                                                      
REMARK 465     SER A  1619                                                      
REMARK 465     GLN A  1620                                                      
REMARK 465     ALA A  1640                                                      
REMARK 465     GLY A  1641                                                      
REMARK 465     PRO A  1642                                                      
REMARK 465     VAL A  1643                                                      
REMARK 465     ILE A  1644                                                      
REMARK 465     SER A  1645                                                      
REMARK 465     THR A  1646                                                      
REMARK 465     THR B  1211                                                      
REMARK 465     LEU B  1212                                                      
REMARK 465     CYS B  1213                                                      
REMARK 465     CYS B  1214                                                      
REMARK 465     TYR B  1215                                                      
REMARK 465     GLY B  1216                                                      
REMARK 465     LYS B  1217                                                      
REMARK 465     GLN B  1218                                                      
REMARK 465     LEU B  1219                                                      
REMARK 465     CYS B  1220                                                      
REMARK 465     THR B  1221                                                      
REMARK 465     ILE B  1222                                                      
REMARK 465     PRO B  1223                                                      
REMARK 465     ARG B  1224                                                      
REMARK 465     ASP B  1225                                                      
REMARK 465     ALA B  1226                                                      
REMARK 465     ALA B  1227                                                      
REMARK 465     TYR B  1228                                                      
REMARK 465     TYR B  1229                                                      
REMARK 465     SER B  1230                                                      
REMARK 465     TYR B  1231                                                      
REMARK 465     GLN B  1232                                                      
REMARK 465     ASN B  1233                                                      
REMARK 465     ARG B  1234                                                      
REMARK 465     TYR B  1235                                                      
REMARK 465     HIS B  1236                                                      
REMARK 465     PHE B  1237                                                      
REMARK 465     CYS B  1238                                                      
REMARK 465     GLU B  1239                                                      
REMARK 465     LYS B  1240                                                      
REMARK 465     CYS B  1241                                                      
REMARK 465     PHE B  1242                                                      
REMARK 465     THR B  1243                                                      
REMARK 465     GLU B  1244                                                      
REMARK 465     ILE B  1245                                                      
REMARK 465     GLN B  1246                                                      
REMARK 465     GLY B  1247                                                      
REMARK 465     GLU B  1248                                                      
REMARK 465     ASN B  1249                                                      
REMARK 465     VAL B  1250                                                      
REMARK 465     THR B  1251                                                      
REMARK 465     LEU B  1252                                                      
REMARK 465     GLY B  1253                                                      
REMARK 465     ASP B  1254                                                      
REMARK 465     ASP B  1255                                                      
REMARK 465     PRO B  1256                                                      
REMARK 465     SER B  1257                                                      
REMARK 465     GLN B  1258                                                      
REMARK 465     PRO B  1259                                                      
REMARK 465     GLN B  1260                                                      
REMARK 465     THR B  1261                                                      
REMARK 465     THR B  1262                                                      
REMARK 465     ILE B  1263                                                      
REMARK 465     SER B  1264                                                      
REMARK 465     LYS B  1265                                                      
REMARK 465     ASP B  1266                                                      
REMARK 465     GLN B  1267                                                      
REMARK 465     PHE B  1268                                                      
REMARK 465     GLU B  1269                                                      
REMARK 465     LYS B  1270                                                      
REMARK 465     LYS B  1271                                                      
REMARK 465     LYS B  1272                                                      
REMARK 465     GLY B  1616                                                      
REMARK 465     SER B  1617                                                      
REMARK 465     GLY B  1618                                                      
REMARK 465     SER B  1619                                                      
REMARK 465     GLN B  1620                                                      
REMARK 465     ALA B  1640                                                      
REMARK 465     GLY B  1641                                                      
REMARK 465     PRO B  1642                                                      
REMARK 465     VAL B  1643                                                      
REMARK 465     ILE B  1644                                                      
REMARK 465     SER B  1645                                                      
REMARK 465     THR B  1646                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ARG A1082    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A1084    CG   CD   CE   NZ                                   
REMARK 470     LYS A1087    CG   CD   CE   NZ                                   
REMARK 470     ARG A1092    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN A1093    CG   CD   OE1  NE2                                  
REMARK 470     LYS A1140    CG   CD   CE   NZ                                   
REMARK 470     GLN A1210    C    O    CG   CD   OE1  NE2                        
REMARK 470     ASN A1273    CG   OD1  ND2                                       
REMARK 470     LYS A1314    CG   CD   CE   NZ                                   
REMARK 470     ARG A1318    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A1345    CD   CE   NZ                                        
REMARK 470     ARG A1444    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A1479    CG   CD   OE1  OE2                                  
REMARK 470     LYS A1493    CG   CD   CE   NZ                                   
REMARK 470     LYS A1496    CG   CD   CE   NZ                                   
REMARK 470     LYS A1498    CG   CD   CE   NZ                                   
REMARK 470     ARG A1499    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A1552    CG   CD   OE1  OE2                                  
REMARK 470     LYS A1555    CD   CE   NZ                                        
REMARK 470     GLU A1556    CG   CD   OE1  OE2                                  
REMARK 470     GLN A1647    CG   CD   OE1  NE2                                  
REMARK 470     ASN A1732    OD1  ND2                                            
REMARK 470     ARG B1082    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B1084    CG   CD   CE   NZ                                   
REMARK 470     LYS B1087    CG   CD   CE   NZ                                   
REMARK 470     ARG B1092    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN B1093    CG   CD   OE1  NE2                                  
REMARK 470     LYS B1140    CG   CD   CE   NZ                                   
REMARK 470     GLN B1210    C    O    CG   CD   OE1  NE2                        
REMARK 470     ASN B1273    CG   OD1  ND2                                       
REMARK 470     LYS B1314    CG   CD   CE   NZ                                   
REMARK 470     ARG B1318    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B1345    CD   CE   NZ                                        
REMARK 470     ARG B1444    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B1479    CG   CD   OE1  OE2                                  
REMARK 470     LYS B1493    CG   CD   CE   NZ                                   
REMARK 470     LYS B1496    CG   CD   CE   NZ                                   
REMARK 470     LYS B1498    CG   CD   CE   NZ                                   
REMARK 470     ARG B1499    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B1552    CG   CD   OE1  OE2                                  
REMARK 470     LYS B1555    CD   CE   NZ                                        
REMARK 470     GLU B1556    CG   CD   OE1  OE2                                  
REMARK 470     GLN B1647    CG   CD   OE1  NE2                                  
REMARK 470     ASN B1732    OD1  ND2                                            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    CYS A1287   CB    CYS A1287   SG     -0.135                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    GLN A1080       83.74   -164.81                                   
REMARK 500    ASP A1274      -33.33    173.43                                   
REMARK 500    GLU A1286      -65.87    -94.66                                   
REMARK 500    CYS A1309      158.02    -49.92                                   
REMARK 500    LYS A1315       31.47    -76.44                                   
REMARK 500    THR A1316      -23.51   -143.30                                   
REMARK 500    PHE A1325       54.43    -93.80                                   
REMARK 500    PHE A1380      -23.31   -140.18                                   
REMARK 500    GLU A1479      114.50    -14.50                                   
REMARK 500    CYS A1487       84.95     69.29                                   
REMARK 500    GLU A1710      -62.73    -93.66                                   
REMARK 500    GLU A1716      -90.13   -109.15                                   
REMARK 500    ASP A1726       76.05   -157.90                                   
REMARK 500    THR A1736      -58.16   -136.05                                   
REMARK 500    LEU A1748      103.05   -163.83                                   
REMARK 500    ALA B1075      114.48     84.21                                   
REMARK 500    GLN B1080       93.45   -168.08                                   
REMARK 500    ARG B1082       31.22    -89.25                                   
REMARK 500    ASP B1274      -36.58    174.06                                   
REMARK 500    GLU B1286      -64.62    -96.29                                   
REMARK 500    CYS B1309      158.14    -47.33                                   
REMARK 500    LYS B1315       29.72    -78.53                                   
REMARK 500    THR B1316      -22.97   -142.00                                   
REMARK 500    PHE B1325       54.82    -90.87                                   
REMARK 500    GLU B1479      111.09    -15.02                                   
REMARK 500    CYS B1487       84.69     69.01                                   
REMARK 500    GLU B1716      -87.25   -108.28                                   
REMARK 500    ASP B1726       69.60   -155.53                                   
REMARK 500    LEU B1748       98.40   -168.37                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN A1801  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS A1200   SG                                                     
REMARK 620 2 CYS A1201   SG  118.0                                              
REMARK 620 3 HIS A1292   ND1 110.5 100.8                                        
REMARK 620 4 CYS A1295   SG  107.4 106.1 114.1                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN A1802  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS A1284   SG                                                     
REMARK 620 2 CYS A1287   SG  106.3                                              
REMARK 620 3 CYS A1309   SG  125.9 112.7                                        
REMARK 620 4 CYS A1312   SG  105.5  97.9 104.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN A1803  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS A1708   SG                                                     
REMARK 620 2 CYS A1711   SG  106.3                                              
REMARK 620 3 CYS A1730   SG  123.5 110.6                                        
REMARK 620 4 CYS A1733   SG  102.5 113.4 100.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN A1804  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS A1721   SG                                                     
REMARK 620 2 CYS A1724   SG  111.3                                              
REMARK 620 3 HIS A1739   NE2  98.6 126.1                                        
REMARK 620 4 HIS A1741   ND1  95.8 108.2 112.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B1801  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B1200   SG                                                     
REMARK 620 2 CYS B1201   SG  112.0                                              
REMARK 620 3 HIS B1292   ND1 114.8 108.4                                        
REMARK 620 4 CYS B1295   SG   97.5 102.4 120.9                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B1802  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B1284   SG                                                     
REMARK 620 2 CYS B1287   SG  101.8                                              
REMARK 620 3 CYS B1309   SG  139.0 117.6                                        
REMARK 620 4 CYS B1312   SG  110.8  87.5  83.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B1803  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B1708   SG                                                     
REMARK 620 2 CYS B1711   SG  111.4                                              
REMARK 620 3 CYS B1730   SG  119.8 110.2                                        
REMARK 620 4 CYS B1733   SG  107.1 116.0  91.1                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B1804  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B1721   SG                                                     
REMARK 620 2 CYS B1724   SG  117.2                                              
REMARK 620 3 HIS B1739   NE2 106.7 115.5                                        
REMARK 620 4 HIS B1741   ND1 102.2 104.1 110.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 1801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 1802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 1803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 1804                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 1801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 1802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 1803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 1804                 
DBREF  5U7G A 1079  1556  UNP    Q8QZV8   Q8QZV8_MOUSE  1073   1550             
DBREF  5U7G B 1079  1556  UNP    Q8QZV8   Q8QZV8_MOUSE  1073   1550             
SEQADV 5U7G GLY A 1074  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ALA A 1075  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G MET A 1076  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY A 1077  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1078  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1557  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY A 1558  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY A 1616  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1617  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY A 1618  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1619  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLN A 1620  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS A 1621  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1622  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TYR A 1623  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ALA A 1624  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR A 1625  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G MET A 1626  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU A 1627  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS A 1628  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS A 1629  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS A 1630  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU A 1631  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL A 1632  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PHE A 1633  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PHE A 1634  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL A 1635  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ILE A 1636  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS A 1637  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1638  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS A 1639  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ALA A 1640  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY A 1641  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PRO A 1642  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL A 1643  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ILE A 1644  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1645  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR A 1646  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLN A 1647  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PRO A 1648  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PRO A 1649  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ILE A 1650  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL A 1651  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP A 1652  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PRO A 1653  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP A 1654  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PRO A 1655  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1656  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1657  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1658  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS A 1659  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP A 1660  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1661  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G MET A 1662  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP A 1663  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY A 1664  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG A 1665  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP A 1666  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ALA A 1667  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PHE A 1668  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1669  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR A 1670  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1671  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ALA A 1672  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG A 1673  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP A 1674  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS A 1675  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS A 1676  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TRP A 1677  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU A 1678  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PHE A 1679  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1680  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1681  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1682  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG A 1683  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG A 1684  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1685  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS A 1686  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TRP A 1687  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1688  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR A 1689  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1690  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS A 1691  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G MET A 1692  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1693  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL A 1694  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU A 1695  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1696  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS A 1697  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR A 1698  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLN A 1699  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY A 1700  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLN A 1701  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP A 1702  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG A 1703  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PHE A 1704  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL A 1705  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TYR A 1706  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR A 1707  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS A 1708  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASN A 1709  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU A 1710  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS A 1711  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS A 1712  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS A 1713  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS A 1714  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL A 1715  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU A 1716  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR A 1717  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG A 1718  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TRP A 1719  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS A 1720  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS A 1721  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR A 1722  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL A 1723  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS A 1724  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU A 1725  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP A 1726  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TYR A 1727  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP A 1728  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1729  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS A 1730  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ILE A 1731  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASN A 1732  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS A 1733  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TYR A 1734  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASN A 1735  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR A 1736  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS A 1737  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER A 1738  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS A 1739  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR A 1740  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS A 1741  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS A 1742  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G MET A 1743  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL A 1744  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS A 1745  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TRP A 1746  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY A 1747  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1748  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY A 1749  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU A 1750  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP A 1751  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY B 1074  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ALA B 1075  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G MET B 1076  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY B 1077  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1078  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1557  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY B 1558  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY B 1616  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1617  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY B 1618  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1619  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLN B 1620  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS B 1621  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1622  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TYR B 1623  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ALA B 1624  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR B 1625  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G MET B 1626  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU B 1627  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS B 1628  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS B 1629  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS B 1630  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU B 1631  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL B 1632  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PHE B 1633  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PHE B 1634  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL B 1635  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ILE B 1636  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS B 1637  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1638  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS B 1639  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ALA B 1640  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY B 1641  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PRO B 1642  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL B 1643  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ILE B 1644  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1645  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR B 1646  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLN B 1647  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PRO B 1648  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PRO B 1649  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ILE B 1650  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL B 1651  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP B 1652  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PRO B 1653  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP B 1654  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PRO B 1655  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1656  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1657  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1658  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS B 1659  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP B 1660  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1661  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G MET B 1662  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP B 1663  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY B 1664  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG B 1665  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP B 1666  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ALA B 1667  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PHE B 1668  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1669  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR B 1670  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1671  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ALA B 1672  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG B 1673  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP B 1674  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS B 1675  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS B 1676  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TRP B 1677  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU B 1678  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PHE B 1679  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1680  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1681  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1682  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG B 1683  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG B 1684  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1685  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS B 1686  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TRP B 1687  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1688  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR B 1689  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1690  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS B 1691  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G MET B 1692  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1693  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL B 1694  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU B 1695  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1696  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS B 1697  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR B 1698  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLN B 1699  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY B 1700  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLN B 1701  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP B 1702  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG B 1703  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G PHE B 1704  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL B 1705  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TYR B 1706  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR B 1707  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS B 1708  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASN B 1709  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU B 1710  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS B 1711  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS B 1712  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS B 1713  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS B 1714  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL B 1715  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU B 1716  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR B 1717  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ARG B 1718  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TRP B 1719  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS B 1720  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS B 1721  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR B 1722  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL B 1723  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS B 1724  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLU B 1725  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP B 1726  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TYR B 1727  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP B 1728  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1729  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS B 1730  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ILE B 1731  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASN B 1732  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G CYS B 1733  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TYR B 1734  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASN B 1735  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR B 1736  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS B 1737  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G SER B 1738  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS B 1739  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G THR B 1740  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G HIS B 1741  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS B 1742  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G MET B 1743  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G VAL B 1744  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LYS B 1745  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G TRP B 1746  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY B 1747  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1748  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G GLY B 1749  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G LEU B 1750  UNP  Q8QZV8              EXPRESSION TAG                 
SEQADV 5U7G ASP B 1751  UNP  Q8QZV8              EXPRESSION TAG                 
SEQRES   1 A  621  GLY ALA MET GLY SER SER GLN PRO ARG LYS LYS ILE PHE          
SEQRES   2 A  621  LYS PRO GLU GLU LEU ARG GLN ALA LEU MET PRO THR LEU          
SEQRES   3 A  621  GLU ALA LEU TYR ARG GLN ASP PRO GLU SER LEU PRO PHE          
SEQRES   4 A  621  ARG GLN PRO VAL ASP PRO GLN LEU LEU GLY ILE PRO ASP          
SEQRES   5 A  621  TYR PHE ASP ILE VAL LYS ASN PRO MET ASP LEU SER THR          
SEQRES   6 A  621  ILE LYS ARG LYS LEU ASP THR GLY GLN TYR GLN GLU PRO          
SEQRES   7 A  621  TRP GLN TYR VAL ASP ASP VAL TRP LEU MET PHE ASN ASN          
SEQRES   8 A  621  ALA TRP LEU TYR ASN ARG LYS THR SER ARG VAL TYR LYS          
SEQRES   9 A  621  PHE CYS SER LYS LEU ALA GLU VAL PHE GLU GLN GLU ILE          
SEQRES  10 A  621  ASP PRO VAL MET GLN SER LEU GLY TYR CYS CYS GLY ARG          
SEQRES  11 A  621  LYS TYR GLU PHE SER PRO GLN THR LEU CYS CYS TYR GLY          
SEQRES  12 A  621  LYS GLN LEU CYS THR ILE PRO ARG ASP ALA ALA TYR TYR          
SEQRES  13 A  621  SER TYR GLN ASN ARG TYR HIS PHE CYS GLU LYS CYS PHE          
SEQRES  14 A  621  THR GLU ILE GLN GLY GLU ASN VAL THR LEU GLY ASP ASP          
SEQRES  15 A  621  PRO SER GLN PRO GLN THR THR ILE SER LYS ASP GLN PHE          
SEQRES  16 A  621  GLU LYS LYS LYS ASN ASP THR LEU ASP PRO GLU PRO PHE          
SEQRES  17 A  621  VAL ASP CYS LYS GLU CYS GLY ARG LYS MET HIS GLN ILE          
SEQRES  18 A  621  CYS VAL LEU HIS TYR ASP ILE ILE TRP PRO SER GLY PHE          
SEQRES  19 A  621  VAL CYS ASP ASN CYS LEU LYS LYS THR GLY ARG PRO ARG          
SEQRES  20 A  621  LYS GLU ASN LYS PHE SER ALA LYS ARG LEU GLN THR THR          
SEQRES  21 A  621  ARG LEU GLY ASN HIS LEU GLU ASP ARG VAL ASN LYS PHE          
SEQRES  22 A  621  LEU ARG ARG GLN ASN HIS PRO GLU ALA GLY GLU VAL PHE          
SEQRES  23 A  621  VAL ARG VAL VAL ALA SER SER ASP LYS THR VAL GLU VAL          
SEQRES  24 A  621  LYS PRO GLY MET LYS SER ARG PHE VAL ASP SER GLY GLU          
SEQRES  25 A  621  MET SER GLU SER PHE PRO TYR ARG THR LYS ALA LEU PHE          
SEQRES  26 A  621  ALA PHE GLU GLU ILE ASP GLY VAL ASP VAL CYS PHE PHE          
SEQRES  27 A  621  GLY MET HIS VAL GLN GLU TYR GLY SER ASP CYS PRO PRO          
SEQRES  28 A  621  PRO ASN THR ARG ARG VAL TYR ILE SER TYR LEU ASP SER          
SEQRES  29 A  621  ILE HIS PHE PHE ARG PRO ARG CYS LEU ARG THR ALA VAL          
SEQRES  30 A  621  TYR HIS GLU ILE LEU ILE GLY TYR LEU GLU TYR VAL LYS          
SEQRES  31 A  621  LYS LEU GLY TYR VAL THR GLY HIS ILE TRP ALA CYS PRO          
SEQRES  32 A  621  PRO SER GLU GLY ASP ASP TYR ILE PHE HIS CYS HIS PRO          
SEQRES  33 A  621  PRO ASP GLN LYS ILE PRO LYS PRO LYS ARG LEU GLN GLU          
SEQRES  34 A  621  TRP TYR LYS LYS MET LEU ASP LYS ALA PHE ALA GLU ARG          
SEQRES  35 A  621  ILE ILE ASN ASP TYR LYS ASP ILE PHE LYS GLN ALA ASN          
SEQRES  36 A  621  GLU ASP ARG LEU THR SER ALA LYS GLU LEU PRO TYR PHE          
SEQRES  37 A  621  GLU GLY ASP PHE TRP PRO ASN VAL LEU GLU GLU SER ILE          
SEQRES  38 A  621  LYS GLU SER GLY GLY SER GLY SER GLN LYS LEU TYR ALA          
SEQRES  39 A  621  THR MET GLU LYS HIS LYS GLU VAL PHE PHE VAL ILE HIS          
SEQRES  40 A  621  LEU HIS ALA GLY PRO VAL ILE SER THR GLN PRO PRO ILE          
SEQRES  41 A  621  VAL ASP PRO ASP PRO LEU LEU SER CYS ASP LEU MET ASP          
SEQRES  42 A  621  GLY ARG ASP ALA PHE LEU THR LEU ALA ARG ASP LYS HIS          
SEQRES  43 A  621  TRP GLU PHE SER SER LEU ARG ARG SER LYS TRP SER THR          
SEQRES  44 A  621  LEU CYS MET LEU VAL GLU LEU HIS THR GLN GLY GLN ASP          
SEQRES  45 A  621  ARG PHE VAL TYR THR CYS ASN GLU CYS LYS HIS HIS VAL          
SEQRES  46 A  621  GLU THR ARG TRP HIS CYS THR VAL CYS GLU ASP TYR ASP          
SEQRES  47 A  621  LEU CYS ILE ASN CYS TYR ASN THR LYS SER HIS THR HIS          
SEQRES  48 A  621  LYS MET VAL LYS TRP GLY LEU GLY LEU ASP                      
SEQRES   1 B  621  GLY ALA MET GLY SER SER GLN PRO ARG LYS LYS ILE PHE          
SEQRES   2 B  621  LYS PRO GLU GLU LEU ARG GLN ALA LEU MET PRO THR LEU          
SEQRES   3 B  621  GLU ALA LEU TYR ARG GLN ASP PRO GLU SER LEU PRO PHE          
SEQRES   4 B  621  ARG GLN PRO VAL ASP PRO GLN LEU LEU GLY ILE PRO ASP          
SEQRES   5 B  621  TYR PHE ASP ILE VAL LYS ASN PRO MET ASP LEU SER THR          
SEQRES   6 B  621  ILE LYS ARG LYS LEU ASP THR GLY GLN TYR GLN GLU PRO          
SEQRES   7 B  621  TRP GLN TYR VAL ASP ASP VAL TRP LEU MET PHE ASN ASN          
SEQRES   8 B  621  ALA TRP LEU TYR ASN ARG LYS THR SER ARG VAL TYR LYS          
SEQRES   9 B  621  PHE CYS SER LYS LEU ALA GLU VAL PHE GLU GLN GLU ILE          
SEQRES  10 B  621  ASP PRO VAL MET GLN SER LEU GLY TYR CYS CYS GLY ARG          
SEQRES  11 B  621  LYS TYR GLU PHE SER PRO GLN THR LEU CYS CYS TYR GLY          
SEQRES  12 B  621  LYS GLN LEU CYS THR ILE PRO ARG ASP ALA ALA TYR TYR          
SEQRES  13 B  621  SER TYR GLN ASN ARG TYR HIS PHE CYS GLU LYS CYS PHE          
SEQRES  14 B  621  THR GLU ILE GLN GLY GLU ASN VAL THR LEU GLY ASP ASP          
SEQRES  15 B  621  PRO SER GLN PRO GLN THR THR ILE SER LYS ASP GLN PHE          
SEQRES  16 B  621  GLU LYS LYS LYS ASN ASP THR LEU ASP PRO GLU PRO PHE          
SEQRES  17 B  621  VAL ASP CYS LYS GLU CYS GLY ARG LYS MET HIS GLN ILE          
SEQRES  18 B  621  CYS VAL LEU HIS TYR ASP ILE ILE TRP PRO SER GLY PHE          
SEQRES  19 B  621  VAL CYS ASP ASN CYS LEU LYS LYS THR GLY ARG PRO ARG          
SEQRES  20 B  621  LYS GLU ASN LYS PHE SER ALA LYS ARG LEU GLN THR THR          
SEQRES  21 B  621  ARG LEU GLY ASN HIS LEU GLU ASP ARG VAL ASN LYS PHE          
SEQRES  22 B  621  LEU ARG ARG GLN ASN HIS PRO GLU ALA GLY GLU VAL PHE          
SEQRES  23 B  621  VAL ARG VAL VAL ALA SER SER ASP LYS THR VAL GLU VAL          
SEQRES  24 B  621  LYS PRO GLY MET LYS SER ARG PHE VAL ASP SER GLY GLU          
SEQRES  25 B  621  MET SER GLU SER PHE PRO TYR ARG THR LYS ALA LEU PHE          
SEQRES  26 B  621  ALA PHE GLU GLU ILE ASP GLY VAL ASP VAL CYS PHE PHE          
SEQRES  27 B  621  GLY MET HIS VAL GLN GLU TYR GLY SER ASP CYS PRO PRO          
SEQRES  28 B  621  PRO ASN THR ARG ARG VAL TYR ILE SER TYR LEU ASP SER          
SEQRES  29 B  621  ILE HIS PHE PHE ARG PRO ARG CYS LEU ARG THR ALA VAL          
SEQRES  30 B  621  TYR HIS GLU ILE LEU ILE GLY TYR LEU GLU TYR VAL LYS          
SEQRES  31 B  621  LYS LEU GLY TYR VAL THR GLY HIS ILE TRP ALA CYS PRO          
SEQRES  32 B  621  PRO SER GLU GLY ASP ASP TYR ILE PHE HIS CYS HIS PRO          
SEQRES  33 B  621  PRO ASP GLN LYS ILE PRO LYS PRO LYS ARG LEU GLN GLU          
SEQRES  34 B  621  TRP TYR LYS LYS MET LEU ASP LYS ALA PHE ALA GLU ARG          
SEQRES  35 B  621  ILE ILE ASN ASP TYR LYS ASP ILE PHE LYS GLN ALA ASN          
SEQRES  36 B  621  GLU ASP ARG LEU THR SER ALA LYS GLU LEU PRO TYR PHE          
SEQRES  37 B  621  GLU GLY ASP PHE TRP PRO ASN VAL LEU GLU GLU SER ILE          
SEQRES  38 B  621  LYS GLU SER GLY GLY SER GLY SER GLN LYS LEU TYR ALA          
SEQRES  39 B  621  THR MET GLU LYS HIS LYS GLU VAL PHE PHE VAL ILE HIS          
SEQRES  40 B  621  LEU HIS ALA GLY PRO VAL ILE SER THR GLN PRO PRO ILE          
SEQRES  41 B  621  VAL ASP PRO ASP PRO LEU LEU SER CYS ASP LEU MET ASP          
SEQRES  42 B  621  GLY ARG ASP ALA PHE LEU THR LEU ALA ARG ASP LYS HIS          
SEQRES  43 B  621  TRP GLU PHE SER SER LEU ARG ARG SER LYS TRP SER THR          
SEQRES  44 B  621  LEU CYS MET LEU VAL GLU LEU HIS THR GLN GLY GLN ASP          
SEQRES  45 B  621  ARG PHE VAL TYR THR CYS ASN GLU CYS LYS HIS HIS VAL          
SEQRES  46 B  621  GLU THR ARG TRP HIS CYS THR VAL CYS GLU ASP TYR ASP          
SEQRES  47 B  621  LEU CYS ILE ASN CYS TYR ASN THR LYS SER HIS THR HIS          
SEQRES  48 B  621  LYS MET VAL LYS TRP GLY LEU GLY LEU ASP                      
HET     ZN  A1801       1                                                       
HET     ZN  A1802       1                                                       
HET     ZN  A1803       1                                                       
HET     ZN  A1804       1                                                       
HET     ZN  B1801       1                                                       
HET     ZN  B1802       1                                                       
HET     ZN  B1803       1                                                       
HET     ZN  B1804       1                                                       
HETNAM      ZN ZINC ION                                                         
FORMUL   3   ZN    8(ZN 2+)                                                     
FORMUL  11  HOH   *45(H2 O)                                                     
HELIX    1 AA1 LYS A 1087  ARG A 1104  1                                  18    
HELIX    2 AA2 SER A 1109  ARG A 1113  5                                   5    
HELIX    3 AA3 ASP A 1117  GLY A 1122  1                                   6    
HELIX    4 AA4 ASP A 1125  VAL A 1130  1                                   6    
HELIX    5 AA5 ASP A 1135  GLY A 1146  1                                  12    
HELIX    6 AA6 GLU A 1150  ASN A 1169  1                                  20    
HELIX    7 AA7 SER A 1173  LEU A 1197  1                                  25    
HELIX    8 AA8 GLN A 1293  LEU A 1297  1                                   5    
HELIX    9 AA9 CYS A 1309  LYS A 1315  1                                   7    
HELIX   10 AB1 THR A 1333  ASN A 1351  1                                  19    
HELIX   11 AB2 LYS A 1373  VAL A 1381  1                                   9    
HELIX   12 AB3 PRO A 1443  CYS A 1445  5                                   3    
HELIX   13 AB4 LEU A 1446  GLY A 1466  1                                  21    
HELIX   14 AB5 LYS A 1496  GLU A 1514  1                                  19    
HELIX   15 AB6 ILE A 1523  ARG A 1531  1                                   9    
HELIX   16 AB7 SER A 1534  LEU A 1538  5                                   5    
HELIX   17 AB8 ASP A 1544  GLU A 1556  1                                  13    
HELIX   18 AB9 LEU A 1622  HIS A 1629  1                                   8    
HELIX   19 AC1 CYS A 1659  ASP A 1663  5                                   5    
HELIX   20 AC2 ARG A 1665  HIS A 1676  1                                  12    
HELIX   21 AC3 SER A 1681  GLY A 1700  1                                  20    
HELIX   22 AC4 CYS A 1730  ASN A 1735  1                                   6    
HELIX   23 AC5 LYS B 1087  ARG B 1104  1                                  18    
HELIX   24 AC6 SER B 1109  ARG B 1113  5                                   5    
HELIX   25 AC7 ASP B 1117  GLY B 1122  1                                   6    
HELIX   26 AC8 ASP B 1125  VAL B 1130  1                                   6    
HELIX   27 AC9 ASP B 1135  GLY B 1146  1                                  12    
HELIX   28 AD1 GLU B 1150  ASN B 1169  1                                  20    
HELIX   29 AD2 SER B 1173  LEU B 1197  1                                  25    
HELIX   30 AD3 GLN B 1293  LEU B 1297  1                                   5    
HELIX   31 AD4 CYS B 1309  LYS B 1315  1                                   7    
HELIX   32 AD5 THR B 1333  ASN B 1351  1                                  19    
HELIX   33 AD6 LYS B 1373  VAL B 1381  1                                   9    
HELIX   34 AD7 PRO B 1443  CYS B 1445  5                                   3    
HELIX   35 AD8 LEU B 1446  GLY B 1466  1                                  21    
HELIX   36 AD9 LYS B 1496  GLU B 1514  1                                  19    
HELIX   37 AE1 ILE B 1523  ASP B 1530  1                                   8    
HELIX   38 AE2 SER B 1534  LEU B 1538  5                                   5    
HELIX   39 AE3 ASP B 1544  GLU B 1556  1                                  13    
HELIX   40 AE4 LEU B 1622  HIS B 1629  1                                   8    
HELIX   41 AE5 CYS B 1659  ASP B 1663  5                                   5    
HELIX   42 AE6 ARG B 1665  HIS B 1676  1                                  12    
HELIX   43 AE7 SER B 1681  GLY B 1700  1                                  20    
HELIX   44 AE8 CYS B 1730  LYS B 1737  1                                   8    
SHEET    1 AA1 2 PHE A1281  ASP A1283  0                                        
SHEET    2 AA1 2 LYS A1290  HIS A1292 -1  O  MET A1291   N  VAL A1282           
SHEET    1 AA2 7 VAL A1358  GLU A1371  0                                        
SHEET    2 AA2 7 SER A1389  ILE A1403 -1  O  TYR A1392   N  LYS A1368           
SHEET    3 AA2 7 VAL A1406  TYR A1418 -1  O  VAL A1408   N  GLU A1401           
SHEET    4 AA2 7 ARG A1429  SER A1437 -1  O  ARG A1429   N  TYR A1418           
SHEET    5 AA2 7 THR A1469  TRP A1473  1  O  HIS A1471   N  ILE A1432           
SHEET    6 AA2 7 PHE A1633  HIS A1637 -1  O  ILE A1636   N  GLY A1470           
SHEET    7 AA2 7 ASP A1519  ASP A1522 -1  N  ASP A1519   O  HIS A1637           
SHEET    1 AA3 3 ASP A1728  LEU A1729  0                                        
SHEET    2 AA3 3 ARG A1718  CYS A1721 -1  N  TRP A1719   O  LEU A1729           
SHEET    3 AA3 3 MET A1743  TRP A1746 -1  O  VAL A1744   N  HIS A1720           
SHEET    1 AA4 2 PHE B1281  ASP B1283  0                                        
SHEET    2 AA4 2 LYS B1290  HIS B1292 -1  O  MET B1291   N  VAL B1282           
SHEET    1 AA5 7 VAL B1358  GLU B1371  0                                        
SHEET    2 AA5 7 SER B1389  ILE B1403 -1  O  TYR B1392   N  LYS B1368           
SHEET    3 AA5 7 VAL B1406  TYR B1418 -1  O  MET B1413   N  LEU B1397           
SHEET    4 AA5 7 ARG B1429  SER B1437 -1  O  ARG B1429   N  TYR B1418           
SHEET    5 AA5 7 THR B1469  TRP B1473  1  O  HIS B1471   N  ILE B1432           
SHEET    6 AA5 7 PHE B1633  HIS B1637 -1  O  ILE B1636   N  GLY B1470           
SHEET    7 AA5 7 ASP B1519  ASP B1522 -1  N  ASP B1519   O  HIS B1637           
SHEET    1 AA6 3 ASP B1728  LEU B1729  0                                        
SHEET    2 AA6 3 ARG B1718  CYS B1721 -1  N  TRP B1719   O  LEU B1729           
SHEET    3 AA6 3 MET B1743  TRP B1746 -1  O  VAL B1744   N  HIS B1720           
LINK         SG  CYS A1200                ZN    ZN A1801     1555   1555  2.39  
LINK         SG  CYS A1201                ZN    ZN A1801     1555   1555  2.27  
LINK         SG  CYS A1284                ZN    ZN A1802     1555   1555  2.41  
LINK         SG  CYS A1287                ZN    ZN A1802     1555   1555  2.12  
LINK         ND1 HIS A1292                ZN    ZN A1801     1555   1555  2.07  
LINK         SG  CYS A1295                ZN    ZN A1801     1555   1555  2.27  
LINK         SG  CYS A1309                ZN    ZN A1802     1555   1555  2.44  
LINK         SG  CYS A1312                ZN    ZN A1802     1555   1555  2.45  
LINK         SG  CYS A1708                ZN    ZN A1803     1555   1555  2.17  
LINK         SG  CYS A1711                ZN    ZN A1803     1555   1555  2.50  
LINK         SG  CYS A1721                ZN    ZN A1804     1555   1555  2.43  
LINK         SG  CYS A1724                ZN    ZN A1804     1555   1555  2.24  
LINK         SG  CYS A1730                ZN    ZN A1803     1555   1555  2.41  
LINK         SG  CYS A1733                ZN    ZN A1803     1555   1555  2.42  
LINK         NE2 HIS A1739                ZN    ZN A1804     1555   1555  1.94  
LINK         ND1 HIS A1741                ZN    ZN A1804     1555   1555  2.16  
LINK         SG  CYS B1200                ZN    ZN B1801     1555   1555  2.48  
LINK         SG  CYS B1201                ZN    ZN B1801     1555   1555  2.30  
LINK         SG  CYS B1284                ZN    ZN B1802     1555   1555  2.50  
LINK         SG  CYS B1287                ZN    ZN B1802     1555   1555  2.23  
LINK         ND1 HIS B1292                ZN    ZN B1801     1555   1555  1.98  
LINK         SG  CYS B1295                ZN    ZN B1801     1555   1555  2.42  
LINK         SG  CYS B1309                ZN    ZN B1802     1555   1555  2.59  
LINK         SG  CYS B1312                ZN    ZN B1802     1555   1555  2.56  
LINK         SG  CYS B1708                ZN    ZN B1803     1555   1555  2.30  
LINK         SG  CYS B1711                ZN    ZN B1803     1555   1555  2.52  
LINK         SG  CYS B1721                ZN    ZN B1804     1555   1555  2.45  
LINK         SG  CYS B1724                ZN    ZN B1804     1555   1555  2.25  
LINK         SG  CYS B1730                ZN    ZN B1803     1555   1555  2.28  
LINK         SG  CYS B1733                ZN    ZN B1803     1555   1555  2.44  
LINK         NE2 HIS B1739                ZN    ZN B1804     1555   1555  2.09  
LINK         ND1 HIS B1741                ZN    ZN B1804     1555   1555  2.11  
CISPEP   1 ASP A 1106    PRO A 1107          0         6.18                     
CISPEP   2 PRO A 1424    PRO A 1425          0        -0.57                     
CISPEP   3 ARG A 1442    PRO A 1443          0        -1.69                     
CISPEP   4 ASP B 1106    PRO B 1107          0         6.31                     
CISPEP   5 PRO B 1424    PRO B 1425          0         0.89                     
CISPEP   6 ARG B 1442    PRO B 1443          0        -2.69                     
SITE     1 AC1  4 CYS A1200  CYS A1201  HIS A1292  CYS A1295                    
SITE     1 AC2  4 CYS A1284  CYS A1287  CYS A1309  CYS A1312                    
SITE     1 AC3  4 CYS A1708  CYS A1711  CYS A1730  CYS A1733                    
SITE     1 AC4  4 CYS A1721  CYS A1724  HIS A1739  HIS A1741                    
SITE     1 AC5  4 CYS B1200  CYS B1201  HIS B1292  CYS B1295                    
SITE     1 AC6  4 CYS B1284  CYS B1287  CYS B1309  CYS B1312                    
SITE     1 AC7  4 CYS B1708  CYS B1711  CYS B1730  CYS B1733                    
SITE     1 AC8  4 CYS B1721  CYS B1724  HIS B1739  HIS B1741                    
CRYST1  214.173   87.170  114.977  90.00 109.68  90.00 C 1 2 1       8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.004669  0.000000  0.001670        0.00000                         
SCALE2      0.000000  0.011472  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.009237        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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