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Database: PDB
Entry: 5U8S
LinkDB: 5U8S
Original site: 5U8S 
HEADER    REPLICATION                             14-DEC-16   5U8S              
TITLE     STRUCTURE OF EUKARYOTIC CMG HELICASE AT A REPLICATION FORK            
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: DNA REPLICATION COMPLEX GINS PROTEIN PSF1;                 
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: PARTNER OF SLD FIVE 1;                                      
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: DNA REPLICATION COMPLEX GINS PROTEIN PSF2;                 
COMPND   8 CHAIN: B;                                                            
COMPND   9 SYNONYM: PARTNER OF SLD FIVE 2;                                      
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: DNA REPLICATION COMPLEX GINS PROTEIN PSF3;                 
COMPND  13 CHAIN: C;                                                            
COMPND  14 SYNONYM: PARTNER OF SLD FIVE 3;                                      
COMPND  15 ENGINEERED: YES;                                                     
COMPND  16 MOL_ID: 4;                                                           
COMPND  17 MOLECULE: DNA REPLICATION COMPLEX GINS PROTEIN SLD5;                 
COMPND  18 CHAIN: D;                                                            
COMPND  19 ENGINEERED: YES;                                                     
COMPND  20 MOL_ID: 5;                                                           
COMPND  21 MOLECULE: CELL DIVISION CONTROL PROTEIN 45;                          
COMPND  22 CHAIN: E;                                                            
COMPND  23 ENGINEERED: YES;                                                     
COMPND  24 MOL_ID: 6;                                                           
COMPND  25 MOLECULE: DNA (26-MER);                                              
COMPND  26 CHAIN: F;                                                            
COMPND  27 ENGINEERED: YES;                                                     
COMPND  28 OTHER_DETAILS: FORK DNA_A (26-MER);                                  
COMPND  29 MOL_ID: 7;                                                           
COMPND  30 MOLECULE: DNA (5'-D(P*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*T)-3'); 
COMPND  31 CHAIN: G;                                                            
COMPND  32 ENGINEERED: YES;                                                     
COMPND  33 OTHER_DETAILS: FORK DNA-B (14-MER);                                  
COMPND  34 MOL_ID: 8;                                                           
COMPND  35 MOLECULE: DNA REPLICATION LICENSING FACTOR MCM2;                     
COMPND  36 CHAIN: 2;                                                            
COMPND  37 SYNONYM: MINICHROMOSOME MAINTENANCE PROTEIN 2;                       
COMPND  38 EC: 3.6.4.12;                                                        
COMPND  39 ENGINEERED: YES;                                                     
COMPND  40 MOL_ID: 9;                                                           
COMPND  41 MOLECULE: DNA REPLICATION LICENSING FACTOR MCM3;                     
COMPND  42 CHAIN: 3;                                                            
COMPND  43 SYNONYM: MINICHROMOSOME MAINTENANCE PROTEIN 3;                       
COMPND  44 EC: 3.6.4.12;                                                        
COMPND  45 ENGINEERED: YES;                                                     
COMPND  46 MOL_ID: 10;                                                          
COMPND  47 MOLECULE: DNA REPLICATION LICENSING FACTOR MCM4;                     
COMPND  48 CHAIN: 4;                                                            
COMPND  49 SYNONYM: CELL DIVISION CONTROL PROTEIN 54;                           
COMPND  50 EC: 3.6.4.12;                                                        
COMPND  51 ENGINEERED: YES;                                                     
COMPND  52 MOL_ID: 11;                                                          
COMPND  53 MOLECULE: MINICHROMOSOME MAINTENANCE PROTEIN 5;                      
COMPND  54 CHAIN: 5;                                                            
COMPND  55 SYNONYM: CELL DIVISION CONTROL PROTEIN 46;                           
COMPND  56 EC: 3.6.4.12;                                                        
COMPND  57 ENGINEERED: YES;                                                     
COMPND  58 MOL_ID: 12;                                                          
COMPND  59 MOLECULE: DNA REPLICATION LICENSING FACTOR MCM6;                     
COMPND  60 CHAIN: 6;                                                            
COMPND  61 SYNONYM: MINICHROMOSOME MAINTENANCE PROTEIN 6;                       
COMPND  62 EC: 3.6.4.12;                                                        
COMPND  63 ENGINEERED: YES;                                                     
COMPND  64 MOL_ID: 13;                                                          
COMPND  65 MOLECULE: DNA REPLICATION LICENSING FACTOR MCM7;                     
COMPND  66 CHAIN: 7;                                                            
COMPND  67 SYNONYM: CELL DIVISION CONTROL PROTEIN 47,MINICHROMOSOME MAINTENANCE 
COMPND  68 PROTEIN 7;                                                           
COMPND  69 EC: 3.6.4.12;                                                        
COMPND  70 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE   3 S288C);                                                              
SOURCE   4 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   5 ORGANISM_TAXID: 559292;                                              
SOURCE   6 STRAIN: ATCC 204508 / S288C;                                         
SOURCE   7 GENE: PSF1, YDR013W, PZA208, YD8119.18;                              
SOURCE   8 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE   9 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE  10 MOL_ID: 2;                                                           
SOURCE  11 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  12 S288C);                                                              
SOURCE  13 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  14 ORGANISM_TAXID: 559292;                                              
SOURCE  15 STRAIN: ATCC 204508 / S288C;                                         
SOURCE  16 GENE: PSF2, YJL072C, HRF213, J1086;                                  
SOURCE  17 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE  18 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE  19 MOL_ID: 3;                                                           
SOURCE  20 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  21 S288C);                                                              
SOURCE  22 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  23 ORGANISM_TAXID: 559292;                                              
SOURCE  24 STRAIN: ATCC 204508 / S288C;                                         
SOURCE  25 GENE: PSF3, YOL146W;                                                 
SOURCE  26 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE  27 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE  28 MOL_ID: 4;                                                           
SOURCE  29 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  30 S288C);                                                              
SOURCE  31 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  32 ORGANISM_TAXID: 559292;                                              
SOURCE  33 STRAIN: ATCC 204508 / S288C;                                         
SOURCE  34 GENE: SLD5, YDR489W;                                                 
SOURCE  35 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE  36 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE  37 MOL_ID: 5;                                                           
SOURCE  38 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  39 S288C);                                                              
SOURCE  40 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  41 ORGANISM_TAXID: 559292;                                              
SOURCE  42 STRAIN: ATCC 204508 / S288C;                                         
SOURCE  43 GENE: CDC45, SLD4, YLR103C, L8004.11;                                
SOURCE  44 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE  45 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE  46 MOL_ID: 6;                                                           
SOURCE  47 SYNTHETIC: YES;                                                      
SOURCE  48 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE  49 ORGANISM_TAXID: 32630;                                               
SOURCE  50 MOL_ID: 7;                                                           
SOURCE  51 SYNTHETIC: YES;                                                      
SOURCE  52 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE  53 ORGANISM_TAXID: 32630;                                               
SOURCE  54 MOL_ID: 8;                                                           
SOURCE  55 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  56 S288C);                                                              
SOURCE  57 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  58 ORGANISM_TAXID: 559292;                                              
SOURCE  59 STRAIN: ATCC 204508 / S288C;                                         
SOURCE  60 GENE: MCM2, YBL023C, YBL0438;                                        
SOURCE  61 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE  62 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE  63 MOL_ID: 9;                                                           
SOURCE  64 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  65 S288C);                                                              
SOURCE  66 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  67 ORGANISM_TAXID: 559292;                                              
SOURCE  68 STRAIN: ATCC 204508 / S288C;                                         
SOURCE  69 GENE: MCM3, YEL032W, SYGP-ORF23;                                     
SOURCE  70 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE  71 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE  72 MOL_ID: 10;                                                          
SOURCE  73 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  74 S288C);                                                              
SOURCE  75 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  76 ORGANISM_TAXID: 559292;                                              
SOURCE  77 STRAIN: ATCC 204508 / S288C;                                         
SOURCE  78 GENE: MCM4, CDC54, HCD21, YPR019W, YP9531.13;                        
SOURCE  79 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE  80 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE  81 MOL_ID: 11;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  83 S288C);                                                              
SOURCE  84 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  85 ORGANISM_TAXID: 559292;                                              
SOURCE  86 STRAIN: ATCC 204508 / S288C;                                         
SOURCE  87 GENE: MCM5, CDC46, YLR274W, L9328.1;                                 
SOURCE  88 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE  89 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE  90 MOL_ID: 12;                                                          
SOURCE  91 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  92 S288C);                                                              
SOURCE  93 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  94 ORGANISM_TAXID: 559292;                                              
SOURCE  95 STRAIN: ATCC 204508 / S288C;                                         
SOURCE  96 GENE: MCM6, YGL201C;                                                 
SOURCE  97 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE  98 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE  99 MOL_ID: 13;                                                          
SOURCE 100 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE 101 S288C);                                                              
SOURCE 102 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 103 ORGANISM_TAXID: 559292;                                              
SOURCE 104 STRAIN: ATCC 204508 / S288C;                                         
SOURCE 105 GENE: MCM7, CDC47, YBR202W, YBR1441;                                 
SOURCE 106 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE 107 EXPRESSION_SYSTEM_TAXID: 4932                                        
KEYWDS    CMG HELICASE, REPLISOME, ORIGIN INITIATION, DNA POLYMERASE, DNA       
KEYWDS   2 REPLICATION, REPLICATION                                             
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    H.LI,B.LI,R.GEORGESCU,Z.YUAN,R.SANTOS,J.SUN,D.ZHANG,O.YURIEVA,        
AUTHOR   2 M.E.O'DONNELL                                                        
REVDAT   7   01-JAN-20 5U8S    1       REMARK                                   
REVDAT   6   03-OCT-18 5U8S    1       REMARK                                   
REVDAT   5   08-NOV-17 5U8S    1       REMARK                                   
REVDAT   4   20-SEP-17 5U8S    1       REMARK                                   
REVDAT   3   08-FEB-17 5U8S    1       JRNL                                     
REVDAT   2   01-FEB-17 5U8S    1       JRNL                                     
REVDAT   1   25-JAN-17 5U8S    0                                                
JRNL        AUTH   R.GEORGESCU,Z.YUAN,L.BAI,R.DE LUNA ALMEIDA SANTOS,J.SUN,     
JRNL        AUTH 2 D.ZHANG,O.YURIEVA,H.LI,M.E.O'DONNELL                         
JRNL        TITL   STRUCTURE OF EUKARYOTIC CMG HELICASE AT A REPLICATION FORK   
JRNL        TITL 2 AND IMPLICATIONS TO REPLISOME ARCHITECTURE AND ORIGIN        
JRNL        TITL 3 INITIATION.                                                  
JRNL        REF    PROC. NATL. ACAD. SCI.        V. 114  E697 2017              
JRNL        REF  2 U.S.A.                                                       
JRNL        REFN                   ESSN 1091-6490                               
JRNL        PMID   28096349                                                     
JRNL        DOI    10.1073/PNAS.1620500114                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    6.10 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : RIGID BODY FIT                      
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 6.100                          
REMARK   3   NUMBER OF PARTICLES               : 243796                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5U8S COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 15-DEC-16.                  
REMARK 100 THE DEPOSITION ID IS D_1000225481.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : CMG-BIOTINYLATED FORK DNA         
REMARK 245                                    -STREPTAVIDIN                     
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 10.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIDECAMERIC                      
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, 2, 3, 4,         
REMARK 350                    AND CHAINS: 5, 6, 7                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     THR B    33                                                      
REMARK 465     ARG B    34                                                      
REMARK 465     GLN B    35                                                      
REMARK 465     LYS B    36                                                      
REMARK 465     ILE B    37                                                      
REMARK 465     ARG B    38                                                      
REMARK 465     GLY B    39                                                      
REMARK 465     ASP B    40                                                      
REMARK 465     ASP B    41                                                      
REMARK 465     ARG B    42                                                      
REMARK 465     GLY B    43                                                      
REMARK 465     THR B    44                                                      
REMARK 465     GLY B    45                                                      
REMARK 465     ASN B    46                                                      
REMARK 465     HIS B    47                                                      
REMARK 465     THR B    48                                                      
REMARK 465     ARG B    49                                                      
REMARK 465     THR B   201                                                      
REMARK 465     ALA B   202                                                      
REMARK 465     GLY B   203                                                      
REMARK 465     THR B   204                                                      
REMARK 465     GLU B   205                                                      
REMARK 465     ASN B   206                                                      
REMARK 465     ASP B   207                                                      
REMARK 465     GLU B   208                                                      
REMARK 465     GLU B   209                                                      
REMARK 465     GLU B   210                                                      
REMARK 465     PHE B   211                                                      
REMARK 465     ASN B   212                                                      
REMARK 465     ILE B   213                                                      
REMARK 465     MET C     1                                                      
REMARK 465     GLY C     2                                                      
REMARK 465     LEU C    30                                                      
REMARK 465     GLU C    31                                                      
REMARK 465     ASN C    32                                                      
REMARK 465     GLY C    59                                                      
REMARK 465     ASP C    60                                                      
REMARK 465     GLU C    61                                                      
REMARK 465     ALA C    62                                                      
REMARK 465     LEU C    63                                                      
REMARK 465     VAL C    64                                                      
REMARK 465     ASP C    65                                                      
REMARK 465     GLU C    66                                                      
REMARK 465     GLU C    67                                                      
REMARK 465     LEU C   142                                                      
REMARK 465     SER C   143                                                      
REMARK 465     ILE C   144                                                      
REMARK 465     ASP C   145                                                      
REMARK 465     LEU C   146                                                      
REMARK 465     ASN C   147                                                      
REMARK 465     ALA C   148                                                      
REMARK 465     ASP C   149                                                      
REMARK 465     SER C   150                                                      
REMARK 465     THR C   151                                                      
REMARK 465     GLY C   152                                                      
REMARK 465     LYS C   153                                                      
REMARK 465     ASN C   154                                                      
REMARK 465     SER C   155                                                      
REMARK 465     ALA C   156                                                      
REMARK 465     ASN C   157                                                      
REMARK 465     THR C   158                                                      
REMARK 465     ASN C   159                                                      
REMARK 465     ILE C   160                                                      
REMARK 465     ALA C   161                                                      
REMARK 465     LYS C   194                                                      
REMARK 465     MET D     1                                                      
REMARK 465     ASP D     2                                                      
REMARK 465     ILE D     3                                                      
REMARK 465     ASN D     4                                                      
REMARK 465     ILE D     5                                                      
REMARK 465     ASP D     6                                                      
REMARK 465     ASP D     7                                                      
REMARK 465     ILE D     8                                                      
REMARK 465     LEU D     9                                                      
REMARK 465     ALA D    10                                                      
REMARK 465     GLU D    11                                                      
REMARK 465     LEU D    12                                                      
REMARK 465     ASP D    13                                                      
REMARK 465     LYS D    14                                                      
REMARK 465     GLU D    15                                                      
REMARK 465     THR D    16                                                      
REMARK 465     THR D    17                                                      
REMARK 465     ALA D    18                                                      
REMARK 465     VAL D    19                                                      
REMARK 465     ASP D    20                                                      
REMARK 465     SER D    21                                                      
REMARK 465     THR D    22                                                      
REMARK 465     LYS D    23                                                      
REMARK 465     ILE D    24                                                      
REMARK 465     THR D    25                                                      
REMARK 465     GLN D    26                                                      
REMARK 465     GLY D    27                                                      
REMARK 465     SER D    28                                                      
REMARK 465     SER D    29                                                      
REMARK 465     SER D    30                                                      
REMARK 465     THR D    31                                                      
REMARK 465     THR D    32                                                      
REMARK 465     HIS D    33                                                      
REMARK 465     ARG D    34                                                      
REMARK 465     ASP D    35                                                      
REMARK 465     ALA D    36                                                      
REMARK 465     ASN D    37                                                      
REMARK 465     THR D    38                                                      
REMARK 465     ILE D    39                                                      
REMARK 465     VAL D    40                                                      
REMARK 465     GLY D    41                                                      
REMARK 465     SER D    42                                                      
REMARK 465     SER D    43                                                      
REMARK 465     LEU D    44                                                      
REMARK 465     ASP D    45                                                      
REMARK 465     LEU D    46                                                      
REMARK 465     ASN D    47                                                      
REMARK 465     ASP D    48                                                      
REMARK 465     LYS D    49                                                      
REMARK 465     THR D    50                                                      
REMARK 465     GLN D    51                                                      
REMARK 465     ILE D    52                                                      
REMARK 465     TYR D    53                                                      
REMARK 465     ALA D   111                                                      
REMARK 465     SER D   112                                                      
REMARK 465     ASN D   113                                                      
REMARK 465     ALA D   114                                                      
REMARK 465     ASN D   115                                                      
REMARK 465     PRO D   116                                                      
REMARK 465     PRO D   117                                                      
REMARK 465     MET D   118                                                      
REMARK 465     PRO D   119                                                      
REMARK 465     ASN D   120                                                      
REMARK 465     LYS D   239                                                      
REMARK 465     TRP D   240                                                      
REMARK 465     ASN D   241                                                      
REMARK 465     GLU D   242                                                      
REMARK 465     ASP D   243                                                      
REMARK 465     PRO D   244                                                      
REMARK 465     LEU D   245                                                      
REMARK 465     LEU D   246                                                      
REMARK 465     GLN D   247                                                      
REMARK 465     ILE D   294                                                      
REMARK 465     MET E     1                                                      
REMARK 465     TYR E     2                                                      
REMARK 465     TYR E     3                                                      
REMARK 465     GLY E     4                                                      
REMARK 465     TYR E   103                                                      
REMARK 465     VAL E   104                                                      
REMARK 465     ILE E   105                                                      
REMARK 465     ASP E   106                                                      
REMARK 465     THR E   107                                                      
REMARK 465     ASP E   108                                                      
REMARK 465     GLU E   109                                                      
REMARK 465     LYS E   110                                                      
REMARK 465     SER E   111                                                      
REMARK 465     GLY E   112                                                      
REMARK 465     GLU E   113                                                      
REMARK 465     ASP E   166                                                      
REMARK 465     GLU E   167                                                      
REMARK 465     GLU E   168                                                      
REMARK 465     SER E   169                                                      
REMARK 465     GLY E   170                                                      
REMARK 465     ASP E   171                                                      
REMARK 465     ASP E   172                                                      
REMARK 465     GLU E   173                                                      
REMARK 465     LEU E   174                                                      
REMARK 465     SER E   175                                                      
REMARK 465     GLY E   176                                                      
REMARK 465     ASP E   177                                                      
REMARK 465     GLU E   178                                                      
REMARK 465     ASN E   179                                                      
REMARK 465     ASP E   180                                                      
REMARK 465     ASN E   181                                                      
REMARK 465     ASN E   182                                                      
REMARK 465     GLY E   183                                                      
REMARK 465     GLY E   184                                                      
REMARK 465     ASP E   185                                                      
REMARK 465     ASP E   186                                                      
REMARK 465     GLU E   187                                                      
REMARK 465     ALA E   188                                                      
REMARK 465     THR E   189                                                      
REMARK 465     ASP E   190                                                      
REMARK 465     ALA E   191                                                      
REMARK 465     ASP E   192                                                      
REMARK 465     GLU E   193                                                      
REMARK 465     VAL E   194                                                      
REMARK 465     THR E   195                                                      
REMARK 465     ASP E   196                                                      
REMARK 465     GLU E   197                                                      
REMARK 465     ASP E   198                                                      
REMARK 465     GLU E   199                                                      
REMARK 465     GLU E   200                                                      
REMARK 465     ASP E   201                                                      
REMARK 465     GLU E   202                                                      
REMARK 465     ASP E   203                                                      
REMARK 465     GLU E   204                                                      
REMARK 465     THR E   205                                                      
REMARK 465     ILE E   206                                                      
REMARK 465     SER E   207                                                      
REMARK 465     ASN E   208                                                      
REMARK 465     LYS E   209                                                      
REMARK 465     ARG E   210                                                      
REMARK 465     GLY E   211                                                      
REMARK 465     ASN E   212                                                      
REMARK 465     SER E   213                                                      
REMARK 465     SER E   214                                                      
REMARK 465     ILE E   215                                                      
REMARK 465     GLY E   216                                                      
REMARK 465     PRO E   217                                                      
REMARK 465     SER E   437                                                      
REMARK 465     THR E   438                                                      
REMARK 465     ASP E   439                                                      
REMARK 465     LYS E   440                                                      
REMARK 465     ASP E   441                                                      
REMARK 465     SER E   442                                                      
REMARK 465     VAL E   443                                                      
REMARK 465     LYS E   444                                                      
REMARK 465     ILE E   445                                                      
REMARK 465     ASN E   446                                                      
REMARK 465     ASN E   447                                                      
REMARK 465     ASP E   448                                                      
REMARK 465     ASN E   449                                                      
REMARK 465     ASN E   450                                                      
REMARK 465     ASP E   451                                                      
REMARK 465     ASP E   452                                                      
REMARK 465     THR E   453                                                      
REMARK 465     ASP E   454                                                      
REMARK 465     GLY E   455                                                      
REMARK 465     GLU E   456                                                      
REMARK 465     GLU E   457                                                      
REMARK 465     GLU E   458                                                      
REMARK 465     GLU E   459                                                      
REMARK 465     ASP E   460                                                      
REMARK 465     ASN E   461                                                      
REMARK 465     LEU E   592                                                      
REMARK 465     ASP E   593                                                      
REMARK 465     THR E   594                                                      
REMARK 465     ILE E   595                                                      
REMARK 465     HIS E   596                                                      
REMARK 465     MET 2     1                                                      
REMARK 465     SER 2     2                                                      
REMARK 465     ASP 2     3                                                      
REMARK 465     ASN 2     4                                                      
REMARK 465     ARG 2     5                                                      
REMARK 465     ARG 2     6                                                      
REMARK 465     ARG 2     7                                                      
REMARK 465     ARG 2     8                                                      
REMARK 465     ARG 2     9                                                      
REMARK 465     GLU 2    10                                                      
REMARK 465     GLU 2    11                                                      
REMARK 465     ASP 2    12                                                      
REMARK 465     ASP 2    13                                                      
REMARK 465     SER 2    14                                                      
REMARK 465     ASP 2    15                                                      
REMARK 465     SER 2    16                                                      
REMARK 465     GLU 2    17                                                      
REMARK 465     ASN 2    18                                                      
REMARK 465     GLU 2    19                                                      
REMARK 465     LEU 2    20                                                      
REMARK 465     PRO 2    21                                                      
REMARK 465     PRO 2    22                                                      
REMARK 465     SER 2    23                                                      
REMARK 465     SER 2    24                                                      
REMARK 465     PRO 2    25                                                      
REMARK 465     GLN 2    26                                                      
REMARK 465     GLN 2    27                                                      
REMARK 465     HIS 2    28                                                      
REMARK 465     PHE 2    29                                                      
REMARK 465     ARG 2    30                                                      
REMARK 465     GLY 2    31                                                      
REMARK 465     GLY 2    32                                                      
REMARK 465     MET 2    33                                                      
REMARK 465     ASN 2    34                                                      
REMARK 465     PRO 2    35                                                      
REMARK 465     VAL 2    36                                                      
REMARK 465     SER 2    37                                                      
REMARK 465     SER 2    38                                                      
REMARK 465     PRO 2    39                                                      
REMARK 465     ILE 2    40                                                      
REMARK 465     GLY 2    41                                                      
REMARK 465     SER 2    42                                                      
REMARK 465     PRO 2    43                                                      
REMARK 465     ASP 2    44                                                      
REMARK 465     MET 2    45                                                      
REMARK 465     ILE 2    46                                                      
REMARK 465     ASN 2    47                                                      
REMARK 465     PRO 2    48                                                      
REMARK 465     GLU 2    49                                                      
REMARK 465     GLY 2    50                                                      
REMARK 465     ASP 2    51                                                      
REMARK 465     ASP 2    52                                                      
REMARK 465     ASN 2    53                                                      
REMARK 465     GLU 2    54                                                      
REMARK 465     VAL 2    55                                                      
REMARK 465     ASP 2    56                                                      
REMARK 465     ASP 2    57                                                      
REMARK 465     VAL 2    58                                                      
REMARK 465     PRO 2    59                                                      
REMARK 465     ASP 2    60                                                      
REMARK 465     ILE 2    61                                                      
REMARK 465     ASP 2    62                                                      
REMARK 465     GLU 2    63                                                      
REMARK 465     VAL 2    64                                                      
REMARK 465     GLU 2    65                                                      
REMARK 465     GLU 2    66                                                      
REMARK 465     GLN 2    67                                                      
REMARK 465     MET 2    68                                                      
REMARK 465     ASN 2    69                                                      
REMARK 465     GLU 2    70                                                      
REMARK 465     VAL 2    71                                                      
REMARK 465     ASP 2    72                                                      
REMARK 465     LEU 2    73                                                      
REMARK 465     MET 2    74                                                      
REMARK 465     ASP 2    75                                                      
REMARK 465     ASP 2    76                                                      
REMARK 465     ASN 2    77                                                      
REMARK 465     MET 2    78                                                      
REMARK 465     TYR 2    79                                                      
REMARK 465     GLU 2    80                                                      
REMARK 465     ASP 2    81                                                      
REMARK 465     TYR 2    82                                                      
REMARK 465     ALA 2    83                                                      
REMARK 465     ALA 2    84                                                      
REMARK 465     ASP 2    85                                                      
REMARK 465     HIS 2    86                                                      
REMARK 465     ASN 2    87                                                      
REMARK 465     ARG 2    88                                                      
REMARK 465     ASP 2    89                                                      
REMARK 465     ARG 2    90                                                      
REMARK 465     TYR 2    91                                                      
REMARK 465     ASP 2    92                                                      
REMARK 465     PRO 2    93                                                      
REMARK 465     ASP 2    94                                                      
REMARK 465     GLN 2    95                                                      
REMARK 465     VAL 2    96                                                      
REMARK 465     ASP 2    97                                                      
REMARK 465     ASP 2    98                                                      
REMARK 465     ARG 2    99                                                      
REMARK 465     GLU 2   100                                                      
REMARK 465     GLN 2   101                                                      
REMARK 465     GLN 2   102                                                      
REMARK 465     GLU 2   103                                                      
REMARK 465     LEU 2   104                                                      
REMARK 465     SER 2   105                                                      
REMARK 465     LEU 2   106                                                      
REMARK 465     SER 2   107                                                      
REMARK 465     GLU 2   108                                                      
REMARK 465     ARG 2   109                                                      
REMARK 465     ARG 2   110                                                      
REMARK 465     ARG 2   111                                                      
REMARK 465     ILE 2   112                                                      
REMARK 465     ASP 2   113                                                      
REMARK 465     ALA 2   114                                                      
REMARK 465     GLN 2   115                                                      
REMARK 465     LEU 2   116                                                      
REMARK 465     ASN 2   117                                                      
REMARK 465     GLU 2   118                                                      
REMARK 465     ARG 2   119                                                      
REMARK 465     ASP 2   120                                                      
REMARK 465     ARG 2   121                                                      
REMARK 465     LEU 2   122                                                      
REMARK 465     LEU 2   123                                                      
REMARK 465     ARG 2   124                                                      
REMARK 465     ASN 2   125                                                      
REMARK 465     VAL 2   126                                                      
REMARK 465     ALA 2   127                                                      
REMARK 465     TYR 2   128                                                      
REMARK 465     ILE 2   129                                                      
REMARK 465     ASP 2   130                                                      
REMARK 465     ASP 2   131                                                      
REMARK 465     GLU 2   132                                                      
REMARK 465     ASP 2   133                                                      
REMARK 465     GLU 2   134                                                      
REMARK 465     GLU 2   135                                                      
REMARK 465     GLN 2   136                                                      
REMARK 465     GLU 2   137                                                      
REMARK 465     GLY 2   138                                                      
REMARK 465     ALA 2   139                                                      
REMARK 465     ALA 2   140                                                      
REMARK 465     GLN 2   141                                                      
REMARK 465     LEU 2   142                                                      
REMARK 465     ASP 2   143                                                      
REMARK 465     GLU 2   144                                                      
REMARK 465     MET 2   145                                                      
REMARK 465     GLY 2   146                                                      
REMARK 465     LEU 2   147                                                      
REMARK 465     PRO 2   148                                                      
REMARK 465     VAL 2   149                                                      
REMARK 465     GLN 2   150                                                      
REMARK 465     ARG 2   151                                                      
REMARK 465     ARG 2   152                                                      
REMARK 465     ARG 2   153                                                      
REMARK 465     ARG 2   154                                                      
REMARK 465     ARG 2   155                                                      
REMARK 465     ARG 2   156                                                      
REMARK 465     GLN 2   157                                                      
REMARK 465     TYR 2   158                                                      
REMARK 465     GLU 2   159                                                      
REMARK 465     ASP 2   160                                                      
REMARK 465     LEU 2   161                                                      
REMARK 465     GLU 2   162                                                      
REMARK 465     ASN 2   163                                                      
REMARK 465     SER 2   164                                                      
REMARK 465     ASP 2   165                                                      
REMARK 465     ASP 2   166                                                      
REMARK 465     ASP 2   167                                                      
REMARK 465     LEU 2   168                                                      
REMARK 465     LEU 2   169                                                      
REMARK 465     SER 2   170                                                      
REMARK 465     ASP 2   171                                                      
REMARK 465     MET 2   172                                                      
REMARK 465     ASP 2   173                                                      
REMARK 465     ILE 2   174                                                      
REMARK 465     ASP 2   175                                                      
REMARK 465     PRO 2   176                                                      
REMARK 465     LEU 2   177                                                      
REMARK 465     ARG 2   178                                                      
REMARK 465     GLU 2   179                                                      
REMARK 465     GLU 2   180                                                      
REMARK 465     LEU 2   181                                                      
REMARK 465     THR 2   182                                                      
REMARK 465     LEU 2   183                                                      
REMARK 465     GLU 2   184                                                      
REMARK 465     SER 2   185                                                      
REMARK 465     LEU 2   186                                                      
REMARK 465     SER 2   187                                                      
REMARK 465     ASN 2   188                                                      
REMARK 465     VAL 2   189                                                      
REMARK 465     LYS 2   190                                                      
REMARK 465     ALA 2   191                                                      
REMARK 465     ASN 2   192                                                      
REMARK 465     SER 2   193                                                      
REMARK 465     TYR 2   194                                                      
REMARK 465     SER 2   195                                                      
REMARK 465     GLU 2   196                                                      
REMARK 465     TRP 2   197                                                      
REMARK 465     ILE 2   198                                                      
REMARK 465     THR 2   199                                                      
REMARK 465     GLN 2   200                                                      
REMARK 465     GLY 2   461                                                      
REMARK 465     ASN 2   462                                                      
REMARK 465     THR 2   463                                                      
REMARK 465     ALA 2   464                                                      
REMARK 465     ASN 2   465                                                      
REMARK 465     GLU 2   466                                                      
REMARK 465     GLY 2   467                                                      
REMARK 465     GLU 2   468                                                      
REMARK 465     GLU 2   469                                                      
REMARK 465     GLY 2   470                                                      
REMARK 465     LEU 2   471                                                      
REMARK 465     ASP 2   472                                                      
REMARK 465     VAL 2   473                                                      
REMARK 465     HIS 2   707                                                      
REMARK 465     PRO 2   708                                                      
REMARK 465     GLU 2   709                                                      
REMARK 465     ASN 2   710                                                      
REMARK 465     ASP 2   711                                                      
REMARK 465     GLU 2   712                                                      
REMARK 465     ASP 2   713                                                      
REMARK 465     ARG 2   714                                                      
REMARK 465     GLU 2   715                                                      
REMARK 465     GLY 2   716                                                      
REMARK 465     GLU 2   717                                                      
REMARK 465     GLU 2   718                                                      
REMARK 465     LEU 2   719                                                      
REMARK 465     LYS 2   720                                                      
REMARK 465     ASN 2   721                                                      
REMARK 465     ASN 2   722                                                      
REMARK 465     GLY 2   723                                                      
REMARK 465     GLU 2   724                                                      
REMARK 465     SER 2   725                                                      
REMARK 465     ALA 2   726                                                      
REMARK 465     ILE 2   727                                                      
REMARK 465     GLU 2   728                                                      
REMARK 465     GLN 2   729                                                      
REMARK 465     GLY 2   730                                                      
REMARK 465     GLU 2   731                                                      
REMARK 465     ASP 2   732                                                      
REMARK 465     GLU 2   733                                                      
REMARK 465     ILE 2   734                                                      
REMARK 465     ASN 2   735                                                      
REMARK 465     GLU 2   736                                                      
REMARK 465     GLN 2   737                                                      
REMARK 465     LEU 2   738                                                      
REMARK 465     ASN 2   739                                                      
REMARK 465     ALA 2   740                                                      
REMARK 465     ARG 2   741                                                      
REMARK 465     GLN 2   742                                                      
REMARK 465     ARG 2   743                                                      
REMARK 465     ARG 2   744                                                      
REMARK 465     LEU 2   745                                                      
REMARK 465     GLN 2   746                                                      
REMARK 465     ARG 2   747                                                      
REMARK 465     GLN 2   748                                                      
REMARK 465     ARG 2   749                                                      
REMARK 465     LYS 2   750                                                      
REMARK 465     LYS 2   751                                                      
REMARK 465     GLU 2   752                                                      
REMARK 465     GLU 2   753                                                      
REMARK 465     GLU 2   754                                                      
REMARK 465     ILE 2   755                                                      
REMARK 465     THR 2   865                                                      
REMARK 465     LEU 2   866                                                      
REMARK 465     GLY 2   867                                                      
REMARK 465     HIS 2   868                                                      
REMARK 465     MET 3     1                                                      
REMARK 465     GLU 3     2                                                      
REMARK 465     GLY 3     3                                                      
REMARK 465     SER 3     4                                                      
REMARK 465     THR 3     5                                                      
REMARK 465     GLY 3     6                                                      
REMARK 465     PHE 3     7                                                      
REMARK 465     ASP 3     8                                                      
REMARK 465     GLY 3     9                                                      
REMARK 465     ASP 3    10                                                      
REMARK 465     ALA 3    11                                                      
REMARK 465     THR 3    12                                                      
REMARK 465     THR 3    13                                                      
REMARK 465     PHE 3    14                                                      
REMARK 465     PHE 3    15                                                      
REMARK 465     ALA 3    16                                                      
REMARK 465     ASP 3    58                                                      
REMARK 465     ASP 3    59                                                      
REMARK 465     GLN 3    60                                                      
REMARK 465     ASP 3    61                                                      
REMARK 465     ASP 3    62                                                      
REMARK 465     ALA 3    63                                                      
REMARK 465     ASP 3    64                                                      
REMARK 465     GLU 3    65                                                      
REMARK 465     ARG 3    66                                                      
REMARK 465     ASP 3    67                                                      
REMARK 465     LEU 3    68                                                      
REMARK 465     LEU 3    69                                                      
REMARK 465     GLY 3    70                                                      
REMARK 465     ASP 3    71                                                      
REMARK 465     ASP 3    72                                                      
REMARK 465     ASP 3    73                                                      
REMARK 465     GLY 3    74                                                      
REMARK 465     ASP 3    75                                                      
REMARK 465     ASP 3    76                                                      
REMARK 465     LEU 3    77                                                      
REMARK 465     GLU 3    78                                                      
REMARK 465     LYS 3    79                                                      
REMARK 465     GLU 3    80                                                      
REMARK 465     LYS 3    81                                                      
REMARK 465     LYS 3    82                                                      
REMARK 465     ALA 3    83                                                      
REMARK 465     ALA 3    84                                                      
REMARK 465     SER 3    85                                                      
REMARK 465     SER 3    86                                                      
REMARK 465     THR 3    87                                                      
REMARK 465     SER 3    88                                                      
REMARK 465     LEU 3    89                                                      
REMARK 465     ASN 3    90                                                      
REMARK 465     PRO 3   142                                                      
REMARK 465     ASN 3   143                                                      
REMARK 465     ALA 3   144                                                      
REMARK 465     SER 3   145                                                      
REMARK 465     ALA 3   146                                                      
REMARK 465     VAL 3   147                                                      
REMARK 465     SER 3   148                                                      
REMARK 465     SER 3   149                                                      
REMARK 465     ARG 3   150                                                      
REMARK 465     SER 3   311                                                      
REMARK 465     ASN 3   312                                                      
REMARK 465     THR 3   313                                                      
REMARK 465     ARG 3   332                                                      
REMARK 465     SER 3   333                                                      
REMARK 465     THR 3   334                                                      
REMARK 465     GLY 3   335                                                      
REMARK 465     VAL 3   336                                                      
REMARK 465     ALA 3   337                                                      
REMARK 465     TYR 3   571                                                      
REMARK 465     LEU 3   572                                                      
REMARK 465     PRO 3   573                                                      
REMARK 465     PRO 3   574                                                      
REMARK 465     GLY 3   575                                                      
REMARK 465     TYR 3   576                                                      
REMARK 465     LEU 3   577                                                      
REMARK 465     GLU 3   578                                                      
REMARK 465     GLY 3   579                                                      
REMARK 465     GLU 3   580                                                      
REMARK 465     PRO 3   581                                                      
REMARK 465     VAL 3   582                                                      
REMARK 465     ARG 3   583                                                      
REMARK 465     GLU 3   584                                                      
REMARK 465     ARG 3   585                                                      
REMARK 465     LEU 3   586                                                      
REMARK 465     ASN 3   587                                                      
REMARK 465     LEU 3   588                                                      
REMARK 465     SER 3   589                                                      
REMARK 465     LEU 3   590                                                      
REMARK 465     ALA 3   591                                                      
REMARK 465     VAL 3   592                                                      
REMARK 465     GLY 3   593                                                      
REMARK 465     GLU 3   594                                                      
REMARK 465     ASP 3   595                                                      
REMARK 465     ALA 3   596                                                      
REMARK 465     ASP 3   597                                                      
REMARK 465     ILE 3   598                                                      
REMARK 465     ASN 3   599                                                      
REMARK 465     PRO 3   600                                                      
REMARK 465     GLU 3   601                                                      
REMARK 465     GLU 3   602                                                      
REMARK 465     HIS 3   603                                                      
REMARK 465     SER 3   604                                                      
REMARK 465     ASN 3   605                                                      
REMARK 465     SER 3   606                                                      
REMARK 465     GLY 3   607                                                      
REMARK 465     ALA 3   608                                                      
REMARK 465     GLY 3   609                                                      
REMARK 465     VAL 3   610                                                      
REMARK 465     GLU 3   611                                                      
REMARK 465     ASN 3   612                                                      
REMARK 465     GLU 3   613                                                      
REMARK 465     GLY 3   614                                                      
REMARK 465     GLU 3   615                                                      
REMARK 465     ASP 3   616                                                      
REMARK 465     ASP 3   617                                                      
REMARK 465     GLU 3   618                                                      
REMARK 465     ASP 3   619                                                      
REMARK 465     HIS 3   620                                                      
REMARK 465     VAL 3   621                                                      
REMARK 465     PHE 3   622                                                      
REMARK 465     GLU 3   623                                                      
REMARK 465     LYS 3   624                                                      
REMARK 465     PHE 3   625                                                      
REMARK 465     ASN 3   626                                                      
REMARK 465     PRO 3   627                                                      
REMARK 465     LEU 3   628                                                      
REMARK 465     LEU 3   629                                                      
REMARK 465     GLN 3   630                                                      
REMARK 465     ALA 3   631                                                      
REMARK 465     GLY 3   632                                                      
REMARK 465     ALA 3   633                                                      
REMARK 465     LYS 3   634                                                      
REMARK 465     LEU 3   635                                                      
REMARK 465     ALA 3   636                                                      
REMARK 465     LYS 3   637                                                      
REMARK 465     ASN 3   638                                                      
REMARK 465     LYS 3   639                                                      
REMARK 465     GLY 3   640                                                      
REMARK 465     ASN 3   641                                                      
REMARK 465     TYR 3   642                                                      
REMARK 465     ASN 3   643                                                      
REMARK 465     GLY 3   644                                                      
REMARK 465     THR 3   645                                                      
REMARK 465     GLU 3   646                                                      
REMARK 465     ILE 3   647                                                      
REMARK 465     PRO 3   648                                                      
REMARK 465     LYS 3   649                                                      
REMARK 465     LEU 3   650                                                      
REMARK 465     GLY 3   739                                                      
REMARK 465     GLU 3   740                                                      
REMARK 465     ASP 3   741                                                      
REMARK 465     ILE 3   742                                                      
REMARK 465     GLY 3   743                                                      
REMARK 465     ASN 3   744                                                      
REMARK 465     ASP 3   745                                                      
REMARK 465     ILE 3   746                                                      
REMARK 465     ASP 3   747                                                      
REMARK 465     GLU 3   748                                                      
REMARK 465     GLU 3   749                                                      
REMARK 465     GLU 3   750                                                      
REMARK 465     SER 3   751                                                      
REMARK 465     GLU 3   752                                                      
REMARK 465     TYR 3   753                                                      
REMARK 465     GLU 3   754                                                      
REMARK 465     GLU 3   755                                                      
REMARK 465     ALA 3   756                                                      
REMARK 465     LEU 3   757                                                      
REMARK 465     SER 3   758                                                      
REMARK 465     LYS 3   759                                                      
REMARK 465     ARG 3   760                                                      
REMARK 465     SER 3   761                                                      
REMARK 465     PRO 3   762                                                      
REMARK 465     GLN 3   763                                                      
REMARK 465     LYS 3   764                                                      
REMARK 465     SER 3   765                                                      
REMARK 465     PRO 3   766                                                      
REMARK 465     LYS 3   767                                                      
REMARK 465     LYS 3   768                                                      
REMARK 465     ARG 3   769                                                      
REMARK 465     GLN 3   770                                                      
REMARK 465     ARG 3   771                                                      
REMARK 465     VAL 3   772                                                      
REMARK 465     ARG 3   773                                                      
REMARK 465     GLN 3   774                                                      
REMARK 465     PRO 3   775                                                      
REMARK 465     ALA 3   776                                                      
REMARK 465     SER 3   777                                                      
REMARK 465     ASN 3   778                                                      
REMARK 465     SER 3   779                                                      
REMARK 465     GLY 3   780                                                      
REMARK 465     SER 3   781                                                      
REMARK 465     PRO 3   782                                                      
REMARK 465     ILE 3   783                                                      
REMARK 465     LYS 3   784                                                      
REMARK 465     SER 3   785                                                      
REMARK 465     THR 3   786                                                      
REMARK 465     PRO 3   787                                                      
REMARK 465     ARG 3   788                                                      
REMARK 465     ARG 3   789                                                      
REMARK 465     SER 3   790                                                      
REMARK 465     THR 3   791                                                      
REMARK 465     ALA 3   792                                                      
REMARK 465     SER 3   793                                                      
REMARK 465     SER 3   794                                                      
REMARK 465     VAL 3   795                                                      
REMARK 465     ASN 3   796                                                      
REMARK 465     ALA 3   797                                                      
REMARK 465     THR 3   798                                                      
REMARK 465     PRO 3   799                                                      
REMARK 465     SER 3   800                                                      
REMARK 465     SER 3   801                                                      
REMARK 465     ALA 3   802                                                      
REMARK 465     ARG 3   803                                                      
REMARK 465     ARG 3   804                                                      
REMARK 465     ILE 3   805                                                      
REMARK 465     LEU 3   806                                                      
REMARK 465     ARG 3   807                                                      
REMARK 465     PHE 3   808                                                      
REMARK 465     GLN 3   809                                                      
REMARK 465     ASP 3   810                                                      
REMARK 465     ASP 3   811                                                      
REMARK 465     GLU 3   812                                                      
REMARK 465     GLN 3   813                                                      
REMARK 465     ASN 3   814                                                      
REMARK 465     ALA 3   815                                                      
REMARK 465     GLY 3   816                                                      
REMARK 465     GLU 3   817                                                      
REMARK 465     ASP 3   818                                                      
REMARK 465     ASP 3   819                                                      
REMARK 465     ASN 3   820                                                      
REMARK 465     ASP 3   821                                                      
REMARK 465     ILE 3   822                                                      
REMARK 465     MET 3   823                                                      
REMARK 465     SER 3   824                                                      
REMARK 465     PRO 3   825                                                      
REMARK 465     LEU 3   826                                                      
REMARK 465     PRO 3   827                                                      
REMARK 465     ALA 3   828                                                      
REMARK 465     ASP 3   829                                                      
REMARK 465     GLU 3   830                                                      
REMARK 465     GLU 3   831                                                      
REMARK 465     ALA 3   832                                                      
REMARK 465     GLU 3   833                                                      
REMARK 465     LEU 3   834                                                      
REMARK 465     GLN 3   835                                                      
REMARK 465     ARG 3   836                                                      
REMARK 465     ARG 3   837                                                      
REMARK 465     LEU 3   838                                                      
REMARK 465     GLN 3   839                                                      
REMARK 465     LEU 3   840                                                      
REMARK 465     GLY 3   841                                                      
REMARK 465     LEU 3   842                                                      
REMARK 465     ARG 3   843                                                      
REMARK 465     VAL 3   844                                                      
REMARK 465     SER 3   845                                                      
REMARK 465     PRO 3   846                                                      
REMARK 465     ARG 3   847                                                      
REMARK 465     ARG 3   848                                                      
REMARK 465     ARG 3   849                                                      
REMARK 465     GLU 3   850                                                      
REMARK 465     HIS 3   851                                                      
REMARK 465     LEU 3   852                                                      
REMARK 465     HIS 3   853                                                      
REMARK 465     ALA 3   854                                                      
REMARK 465     PRO 3   855                                                      
REMARK 465     GLU 3   856                                                      
REMARK 465     GLU 3   857                                                      
REMARK 465     GLY 3   858                                                      
REMARK 465     SER 3   859                                                      
REMARK 465     SER 3   860                                                      
REMARK 465     GLY 3   861                                                      
REMARK 465     PRO 3   862                                                      
REMARK 465     LEU 3   863                                                      
REMARK 465     THR 3   864                                                      
REMARK 465     GLU 3   865                                                      
REMARK 465     VAL 3   866                                                      
REMARK 465     GLY 3   867                                                      
REMARK 465     THR 3   868                                                      
REMARK 465     PRO 3   869                                                      
REMARK 465     ARG 3   870                                                      
REMARK 465     LEU 3   871                                                      
REMARK 465     PRO 3   872                                                      
REMARK 465     ASN 3   873                                                      
REMARK 465     VAL 3   874                                                      
REMARK 465     SER 3   875                                                      
REMARK 465     SER 3   876                                                      
REMARK 465     ALA 3   877                                                      
REMARK 465     GLY 3   878                                                      
REMARK 465     GLN 3   879                                                      
REMARK 465     ASP 3   880                                                      
REMARK 465     ASP 3   881                                                      
REMARK 465     GLU 3   882                                                      
REMARK 465     GLN 3   883                                                      
REMARK 465     GLN 3   884                                                      
REMARK 465     GLN 3   885                                                      
REMARK 465     SER 3   886                                                      
REMARK 465     VAL 3   887                                                      
REMARK 465     ILE 3   888                                                      
REMARK 465     SER 3   889                                                      
REMARK 465     PHE 3   890                                                      
REMARK 465     ASP 3   891                                                      
REMARK 465     ASN 3   892                                                      
REMARK 465     VAL 3   893                                                      
REMARK 465     GLU 3   894                                                      
REMARK 465     PRO 3   895                                                      
REMARK 465     GLY 3   896                                                      
REMARK 465     THR 3   897                                                      
REMARK 465     ILE 3   898                                                      
REMARK 465     SER 3   899                                                      
REMARK 465     THR 3   900                                                      
REMARK 465     GLY 3   901                                                      
REMARK 465     ARG 3   902                                                      
REMARK 465     LEU 3   903                                                      
REMARK 465     SER 3   904                                                      
REMARK 465     LEU 3   905                                                      
REMARK 465     ILE 3   906                                                      
REMARK 465     SER 3   907                                                      
REMARK 465     GLY 3   908                                                      
REMARK 465     ILE 3   909                                                      
REMARK 465     ILE 3   910                                                      
REMARK 465     ALA 3   911                                                      
REMARK 465     ARG 3   912                                                      
REMARK 465     LEU 3   913                                                      
REMARK 465     MET 3   914                                                      
REMARK 465     GLN 3   915                                                      
REMARK 465     THR 3   916                                                      
REMARK 465     GLU 3   917                                                      
REMARK 465     ILE 3   918                                                      
REMARK 465     PHE 3   919                                                      
REMARK 465     GLU 3   920                                                      
REMARK 465     GLU 3   921                                                      
REMARK 465     GLU 3   922                                                      
REMARK 465     SER 3   923                                                      
REMARK 465     TYR 3   924                                                      
REMARK 465     PRO 3   925                                                      
REMARK 465     VAL 3   926                                                      
REMARK 465     ALA 3   927                                                      
REMARK 465     SER 3   928                                                      
REMARK 465     LEU 3   929                                                      
REMARK 465     PHE 3   930                                                      
REMARK 465     GLU 3   931                                                      
REMARK 465     ARG 3   932                                                      
REMARK 465     ILE 3   933                                                      
REMARK 465     ASN 3   934                                                      
REMARK 465     GLU 3   935                                                      
REMARK 465     GLU 3   936                                                      
REMARK 465     LEU 3   937                                                      
REMARK 465     PRO 3   938                                                      
REMARK 465     GLU 3   939                                                      
REMARK 465     GLU 3   940                                                      
REMARK 465     GLU 3   941                                                      
REMARK 465     LYS 3   942                                                      
REMARK 465     PHE 3   943                                                      
REMARK 465     SER 3   944                                                      
REMARK 465     ALA 3   945                                                      
REMARK 465     GLN 3   946                                                      
REMARK 465     GLU 3   947                                                      
REMARK 465     TYR 3   948                                                      
REMARK 465     LEU 3   949                                                      
REMARK 465     ALA 3   950                                                      
REMARK 465     GLY 3   951                                                      
REMARK 465     LEU 3   952                                                      
REMARK 465     LYS 3   953                                                      
REMARK 465     ILE 3   954                                                      
REMARK 465     MET 3   955                                                      
REMARK 465     SER 3   956                                                      
REMARK 465     ASP 3   957                                                      
REMARK 465     ARG 3   958                                                      
REMARK 465     ASN 3   959                                                      
REMARK 465     ASN 3   960                                                      
REMARK 465     LEU 3   961                                                      
REMARK 465     MET 3   962                                                      
REMARK 465     VAL 3   963                                                      
REMARK 465     ALA 3   964                                                      
REMARK 465     ASP 3   965                                                      
REMARK 465     ASP 3   966                                                      
REMARK 465     LYS 3   967                                                      
REMARK 465     VAL 3   968                                                      
REMARK 465     TRP 3   969                                                      
REMARK 465     ARG 3   970                                                      
REMARK 465     VAL 3   971                                                      
REMARK 465     MET 4     1                                                      
REMARK 465     SER 4     2                                                      
REMARK 465     GLN 4     3                                                      
REMARK 465     GLN 4     4                                                      
REMARK 465     SER 4     5                                                      
REMARK 465     SER 4     6                                                      
REMARK 465     SER 4     7                                                      
REMARK 465     PRO 4     8                                                      
REMARK 465     THR 4     9                                                      
REMARK 465     LYS 4    10                                                      
REMARK 465     GLU 4    11                                                      
REMARK 465     ASP 4    12                                                      
REMARK 465     ASN 4    13                                                      
REMARK 465     ASN 4    14                                                      
REMARK 465     SER 4    15                                                      
REMARK 465     SER 4    16                                                      
REMARK 465     SER 4    17                                                      
REMARK 465     PRO 4    18                                                      
REMARK 465     VAL 4    19                                                      
REMARK 465     VAL 4    20                                                      
REMARK 465     PRO 4    21                                                      
REMARK 465     ASN 4    22                                                      
REMARK 465     PRO 4    23                                                      
REMARK 465     ASP 4    24                                                      
REMARK 465     SER 4    25                                                      
REMARK 465     VAL 4    26                                                      
REMARK 465     PRO 4    27                                                      
REMARK 465     PRO 4    28                                                      
REMARK 465     GLN 4    29                                                      
REMARK 465     LEU 4    30                                                      
REMARK 465     SER 4    31                                                      
REMARK 465     SER 4    32                                                      
REMARK 465     PRO 4    33                                                      
REMARK 465     ALA 4    34                                                      
REMARK 465     LEU 4    35                                                      
REMARK 465     PHE 4    36                                                      
REMARK 465     TYR 4    37                                                      
REMARK 465     SER 4    38                                                      
REMARK 465     SER 4    39                                                      
REMARK 465     SER 4    40                                                      
REMARK 465     SER 4    41                                                      
REMARK 465     SER 4    42                                                      
REMARK 465     GLN 4    43                                                      
REMARK 465     GLY 4    44                                                      
REMARK 465     ASP 4    45                                                      
REMARK 465     ILE 4    46                                                      
REMARK 465     TYR 4    47                                                      
REMARK 465     GLY 4    48                                                      
REMARK 465     ARG 4    49                                                      
REMARK 465     ASN 4    50                                                      
REMARK 465     ASN 4    51                                                      
REMARK 465     SER 4    52                                                      
REMARK 465     GLN 4    53                                                      
REMARK 465     ASN 4    54                                                      
REMARK 465     LEU 4    55                                                      
REMARK 465     SER 4    56                                                      
REMARK 465     GLN 4    57                                                      
REMARK 465     GLY 4    58                                                      
REMARK 465     GLU 4    59                                                      
REMARK 465     GLY 4    60                                                      
REMARK 465     ASN 4    61                                                      
REMARK 465     ILE 4    62                                                      
REMARK 465     ARG 4    63                                                      
REMARK 465     ALA 4    64                                                      
REMARK 465     ALA 4    65                                                      
REMARK 465     ILE 4    66                                                      
REMARK 465     GLY 4    67                                                      
REMARK 465     SER 4    68                                                      
REMARK 465     SER 4    69                                                      
REMARK 465     PRO 4    70                                                      
REMARK 465     LEU 4    71                                                      
REMARK 465     ASN 4    72                                                      
REMARK 465     PHE 4    73                                                      
REMARK 465     PRO 4    74                                                      
REMARK 465     SER 4    75                                                      
REMARK 465     SER 4    76                                                      
REMARK 465     SER 4    77                                                      
REMARK 465     GLN 4    78                                                      
REMARK 465     ARG 4    79                                                      
REMARK 465     GLN 4    80                                                      
REMARK 465     ASN 4    81                                                      
REMARK 465     SER 4    82                                                      
REMARK 465     ASP 4    83                                                      
REMARK 465     VAL 4    84                                                      
REMARK 465     PHE 4    85                                                      
REMARK 465     GLN 4    86                                                      
REMARK 465     SER 4    87                                                      
REMARK 465     GLN 4    88                                                      
REMARK 465     GLY 4    89                                                      
REMARK 465     ARG 4    90                                                      
REMARK 465     GLN 4    91                                                      
REMARK 465     GLY 4    92                                                      
REMARK 465     ARG 4    93                                                      
REMARK 465     ILE 4    94                                                      
REMARK 465     ARG 4    95                                                      
REMARK 465     SER 4    96                                                      
REMARK 465     SER 4    97                                                      
REMARK 465     ALA 4    98                                                      
REMARK 465     SER 4    99                                                      
REMARK 465     ALA 4   100                                                      
REMARK 465     SER 4   101                                                      
REMARK 465     GLY 4   102                                                      
REMARK 465     ARG 4   103                                                      
REMARK 465     SER 4   104                                                      
REMARK 465     ARG 4   105                                                      
REMARK 465     TYR 4   106                                                      
REMARK 465     HIS 4   107                                                      
REMARK 465     SER 4   108                                                      
REMARK 465     ASP 4   109                                                      
REMARK 465     LEU 4   110                                                      
REMARK 465     ARG 4   111                                                      
REMARK 465     SER 4   112                                                      
REMARK 465     ASP 4   113                                                      
REMARK 465     ARG 4   114                                                      
REMARK 465     ALA 4   115                                                      
REMARK 465     LEU 4   116                                                      
REMARK 465     PRO 4   117                                                      
REMARK 465     THR 4   118                                                      
REMARK 465     SER 4   119                                                      
REMARK 465     SER 4   120                                                      
REMARK 465     SER 4   121                                                      
REMARK 465     SER 4   122                                                      
REMARK 465     LEU 4   123                                                      
REMARK 465     GLY 4   124                                                      
REMARK 465     ARG 4   125                                                      
REMARK 465     ASN 4   126                                                      
REMARK 465     GLY 4   127                                                      
REMARK 465     GLN 4   128                                                      
REMARK 465     ASN 4   129                                                      
REMARK 465     ARG 4   130                                                      
REMARK 465     VAL 4   131                                                      
REMARK 465     HIS 4   132                                                      
REMARK 465     MET 4   133                                                      
REMARK 465     ARG 4   134                                                      
REMARK 465     ARG 4   135                                                      
REMARK 465     ASN 4   136                                                      
REMARK 465     ASP 4   137                                                      
REMARK 465     ILE 4   138                                                      
REMARK 465     HIS 4   139                                                      
REMARK 465     THR 4   140                                                      
REMARK 465     SER 4   141                                                      
REMARK 465     ASP 4   142                                                      
REMARK 465     LEU 4   143                                                      
REMARK 465     SER 4   144                                                      
REMARK 465     SER 4   145                                                      
REMARK 465     PRO 4   146                                                      
REMARK 465     ARG 4   147                                                      
REMARK 465     ARG 4   148                                                      
REMARK 465     ILE 4   149                                                      
REMARK 465     VAL 4   150                                                      
REMARK 465     ASP 4   151                                                      
REMARK 465     PHE 4   152                                                      
REMARK 465     ASP 4   153                                                      
REMARK 465     THR 4   154                                                      
REMARK 465     ARG 4   155                                                      
REMARK 465     SER 4   156                                                      
REMARK 465     GLY 4   157                                                      
REMARK 465     VAL 4   158                                                      
REMARK 465     ASN 4   159                                                      
REMARK 465     THR 4   160                                                      
REMARK 465     LEU 4   161                                                      
REMARK 465     ASP 4   162                                                      
REMARK 465     THR 4   163                                                      
REMARK 465     SER 4   164                                                      
REMARK 465     SER 4   165                                                      
REMARK 465     SER 4   166                                                      
REMARK 465     SER 4   167                                                      
REMARK 465     ALA 4   168                                                      
REMARK 465     PRO 4   169                                                      
REMARK 465     PRO 4   170                                                      
REMARK 465     SER 4   171                                                      
REMARK 465     GLU 4   172                                                      
REMARK 465     ALA 4   173                                                      
REMARK 465     SER 4   174                                                      
REMARK 465     GLU 4   175                                                      
REMARK 465     PRO 4   176                                                      
REMARK 465     GLU 4   213                                                      
REMARK 465     GLU 4   214                                                      
REMARK 465     PHE 4   215                                                      
REMARK 465     ILE 4   216                                                      
REMARK 465     ASN 4   217                                                      
REMARK 465     ASN 4   218                                                      
REMARK 465     THR 4   219                                                      
REMARK 465     THR 4   220                                                      
REMARK 465     SER 4   470A                                                     
REMARK 465     ASP 4   470B                                                     
REMARK 465     LYS 4   470C                                                     
REMARK 465     ARG 4   470D                                                     
REMARK 465     LEU 4   470E                                                     
REMARK 465     ASP 4   470F                                                     
REMARK 465     VAL 4   470G                                                     
REMARK 465     ASP 4   470H                                                     
REMARK 465     THR 4   470I                                                     
REMARK 465     SER 4   470J                                                     
REMARK 465     THR 4   470K                                                     
REMARK 465     ILE 4   470L                                                     
REMARK 465     GLU 4   470M                                                     
REMARK 465     GLN 4   470N                                                     
REMARK 465     GLU 4   470O                                                     
REMARK 465     LEU 4   470P                                                     
REMARK 465     MET 4   470Q                                                     
REMARK 465     GLN 4   470R                                                     
REMARK 465     ASN 4   470S                                                     
REMARK 465     LYS 4   470T                                                     
REMARK 465     VAL 4   470U                                                     
REMARK 465     ASP 4   470V                                                     
REMARK 465     HIS 4   470W                                                     
REMARK 465     ASN 4   470X                                                     
REMARK 465     GLU 4   470Y                                                     
REMARK 465     VAL 4   470Z                                                     
REMARK 465     GLU 4   471A                                                     
REMARK 465     GLU 4   471B                                                     
REMARK 465     ASP 4   731                                                      
REMARK 465     LYS 4   732                                                      
REMARK 465     PRO 4   733                                                      
REMARK 465     GLU 4   734                                                      
REMARK 465     HIS 4   735                                                      
REMARK 465     ILE 4   736                                                      
REMARK 465     SER 4   737                                                      
REMARK 465     GLN 4   738                                                      
REMARK 465     ASP 4   739                                                      
REMARK 465     ASP 4   740                                                      
REMARK 465     MET 4   780                                                      
REMARK 465     GLY 4   781                                                      
REMARK 465     ASP 4   782                                                      
REMARK 465     ASP 4   783                                                      
REMARK 465     SER 4   784                                                      
REMARK 465     ARG 4   785                                                      
REMARK 465     SER 4   786                                                      
REMARK 465     ASP 4   787                                                      
REMARK 465     GLU 4   788                                                      
REMARK 465     LYS 4   789                                                      
REMARK 465     ARG 4   790                                                      
REMARK 465     ILE 4   791                                                      
REMARK 465     THR 4   792                                                      
REMARK 465     ASP 4   839                                                      
REMARK 465     PRO 4   840                                                      
REMARK 465     LYS 4   841                                                      
REMARK 465     THR 4   842                                                      
REMARK 465     GLY 4   843                                                      
REMARK 465     LYS 4   844                                                      
REMARK 465     ILE 4   845                                                      
REMARK 465     ASP 4   846                                                      
REMARK 465     MET 4   847                                                      
REMARK 465     ASN 4   848                                                      
REMARK 465     LEU 4   849                                                      
REMARK 465     VAL 4   850                                                      
REMARK 465     ASN 4   930                                                      
REMARK 465     ASN 4   931                                                      
REMARK 465     ARG 4   932                                                      
REMARK 465     VAL 4   933                                                      
REMARK 465     MET 5     1                                                      
REMARK 465     SER 5     2                                                      
REMARK 465     PHE 5     3                                                      
REMARK 465     ASP 5     4                                                      
REMARK 465     ARG 5     5                                                      
REMARK 465     PRO 5     6                                                      
REMARK 465     GLU 5     7                                                      
REMARK 465     ILE 5     8                                                      
REMARK 465     TYR 5     9                                                      
REMARK 465     SER 5    10                                                      
REMARK 465     ALA 5    11                                                      
REMARK 465     PRO 5    12                                                      
REMARK 465     VAL 5    13                                                      
REMARK 465     LEU 5    14                                                      
REMARK 465     GLN 5    15                                                      
REMARK 465     GLY 5    16                                                      
REMARK 465     GLU 5    17                                                      
REMARK 465     SER 5    18                                                      
REMARK 465     PRO 5    19                                                      
REMARK 465     ASN 5    20                                                      
REMARK 465     ASP 5    21                                                      
REMARK 465     ASP 5    22                                                      
REMARK 465     ASP 5    23                                                      
REMARK 465     LEU 5   104                                                      
REMARK 465     SER 5   105                                                      
REMARK 465     ARG 5   106                                                      
REMARK 465     ALA 5   107                                                      
REMARK 465     GLN 5   108                                                      
REMARK 465     SER 5   109                                                      
REMARK 465     ALA 5   110                                                      
REMARK 465     ASN 5   111                                                      
REMARK 465     ASN 5   112                                                      
REMARK 465     ASN 5   113                                                      
REMARK 465     ASP 5   114                                                      
REMARK 465     LYS 5   115                                                      
REMARK 465     ASP 5   116                                                      
REMARK 465     PRO 5   117                                                      
REMARK 465     GLU 5   118                                                      
REMARK 465     ASN 5   119                                                      
REMARK 465     THR 5   120                                                      
REMARK 465     SER 5   121                                                      
REMARK 465     MET 5   122                                                      
REMARK 465     ASP 5   123                                                      
REMARK 465     THR 5   124                                                      
REMARK 465     ASP 5   125                                                      
REMARK 465     SER 5   126                                                      
REMARK 465     LEU 5   127                                                      
REMARK 465     LEU 5   128                                                      
REMARK 465     LEU 5   129                                                      
REMARK 465     SER 5   199                                                      
REMARK 465     ILE 5   200                                                      
REMARK 465     LEU 5   212                                                      
REMARK 465     SER 5   213                                                      
REMARK 465     THR 5   214                                                      
REMARK 465     ILE 5   215                                                      
REMARK 465     GLU 5   216                                                      
REMARK 465     SER 5   217                                                      
REMARK 465     GLU 5   218                                                      
REMARK 465     SER 5   219                                                      
REMARK 465     SER 5   220                                                      
REMARK 465     MET 5   221                                                      
REMARK 465     ALA 5   222                                                      
REMARK 465     ASN 5   223                                                      
REMARK 465     GLU 5   224                                                      
REMARK 465     SER 5   225                                                      
REMARK 465     ASN 5   226                                                      
REMARK 465     ILE 5   227                                                      
REMARK 465     GLY 5   228                                                      
REMARK 465     ASP 5   229                                                      
REMARK 465     GLU 5   230                                                      
REMARK 465     SER 5   231                                                      
REMARK 465     THR 5   232                                                      
REMARK 465     LYS 5   233                                                      
REMARK 465     LYS 5   234                                                      
REMARK 465     GLY 5   306                                                      
REMARK 465     ALA 5   307                                                      
REMARK 465     GLY 5   308                                                      
REMARK 465     SER 5   309                                                      
REMARK 465     GLY 5   310                                                      
REMARK 465     ARG 5   311                                                      
REMARK 465     SER 5   312                                                      
REMARK 465     GLY 5   313                                                      
REMARK 465     GLY 5   314                                                      
REMARK 465     GLY 5   315                                                      
REMARK 465     ASN 5   316                                                      
REMARK 465     GLY 5   317                                                      
REMARK 465     GLY 5   318                                                      
REMARK 465     SER 5   340                                                      
REMARK 465     SER 5   341                                                      
REMARK 465     ILE 5   342                                                      
REMARK 465     TRP 5   343                                                      
REMARK 465     ASN 5   344                                                      
REMARK 465     SER 5   345                                                      
REMARK 465     SER 5   644                                                      
REMARK 465     SER 5   645                                                      
REMARK 465     ILE 5   646                                                      
REMARK 465     GLN 5   694                                                      
REMARK 465     ASP 5   695                                                      
REMARK 465     PRO 5   696                                                      
REMARK 465     ILE 5   697                                                      
REMARK 465     GLY 5   698                                                      
REMARK 465     GLY 5   699                                                      
REMARK 465     LEU 5   700                                                      
REMARK 465     ASN 5   701                                                      
REMARK 465     GLN 5   702                                                      
REMARK 465     ALA 5   703                                                      
REMARK 465     SER 5   704                                                      
REMARK 465     GLY 5   705                                                      
REMARK 465     THR 5   706                                                      
REMARK 465     SER 5   707                                                      
REMARK 465     LEU 5   708                                                      
REMARK 465     SER 5   709                                                      
REMARK 465     GLU 5   710                                                      
REMARK 465     ILE 5   711                                                      
REMARK 465     ARG 5   712                                                      
REMARK 465     ARG 5   713                                                      
REMARK 465     PHE 5   714                                                      
REMARK 465     GLU 5   715                                                      
REMARK 465     GLN 5   716                                                      
REMARK 465     GLU 5   717                                                      
REMARK 465     LEU 5   718                                                      
REMARK 465     LYS 5   719                                                      
REMARK 465     ARG 5   720                                                      
REMARK 465     ARG 5   721                                                      
REMARK 465     LEU 5   722                                                      
REMARK 465     PRO 5   723                                                      
REMARK 465     ILE 5   724                                                      
REMARK 465     GLY 5   725                                                      
REMARK 465     TRP 5   726                                                      
REMARK 465     SER 5   727                                                      
REMARK 465     THR 5   728                                                      
REMARK 465     SER 5   729                                                      
REMARK 465     TYR 5   730                                                      
REMARK 465     GLN 5   731                                                      
REMARK 465     THR 5   732                                                      
REMARK 465     LEU 5   733                                                      
REMARK 465     ARG 5   734                                                      
REMARK 465     ARG 5   735                                                      
REMARK 465     GLU 5   736                                                      
REMARK 465     PHE 5   737                                                      
REMARK 465     VAL 5   738                                                      
REMARK 465     ASP 5   739                                                      
REMARK 465     THR 5   740                                                      
REMARK 465     HIS 5   741                                                      
REMARK 465     ARG 5   742                                                      
REMARK 465     PHE 5   743                                                      
REMARK 465     SER 5   744                                                      
REMARK 465     GLN 5   745                                                      
REMARK 465     LEU 5   746                                                      
REMARK 465     ALA 5   747                                                      
REMARK 465     LEU 5   748                                                      
REMARK 465     ASP 5   749                                                      
REMARK 465     LYS 5   750                                                      
REMARK 465     ALA 5   751                                                      
REMARK 465     LEU 5   752                                                      
REMARK 465     TYR 5   753                                                      
REMARK 465     ALA 5   754                                                      
REMARK 465     LEU 5   755                                                      
REMARK 465     GLU 5   756                                                      
REMARK 465     LYS 5   757                                                      
REMARK 465     HIS 5   758                                                      
REMARK 465     GLU 5   759                                                      
REMARK 465     THR 5   760                                                      
REMARK 465     ILE 5   761                                                      
REMARK 465     GLN 5   762                                                      
REMARK 465     LEU 5   763                                                      
REMARK 465     ARG 5   764                                                      
REMARK 465     HIS 5   765                                                      
REMARK 465     GLN 5   766                                                      
REMARK 465     GLY 5   767                                                      
REMARK 465     GLN 5   768                                                      
REMARK 465     ASN 5   769                                                      
REMARK 465     ILE 5   770                                                      
REMARK 465     TYR 5   771                                                      
REMARK 465     ARG 5   772                                                      
REMARK 465     SER 5   773                                                      
REMARK 465     GLY 5   774                                                      
REMARK 465     VAL 5   775                                                      
REMARK 465     MET 6     1                                                      
REMARK 465     SER 6     2                                                      
REMARK 465     SER 6     3                                                      
REMARK 465     PRO 6     4                                                      
REMARK 465     PHE 6     5                                                      
REMARK 465     PRO 6     6                                                      
REMARK 465     ALA 6     7                                                      
REMARK 465     ASP 6     8                                                      
REMARK 465     THR 6     9                                                      
REMARK 465     PRO 6    10                                                      
REMARK 465     SER 6    11                                                      
REMARK 465     SER 6    12                                                      
REMARK 465     ASN 6    13                                                      
REMARK 465     ARG 6    14                                                      
REMARK 465     PRO 6    15                                                      
REMARK 465     SER 6    16                                                      
REMARK 465     ASN 6    17                                                      
REMARK 465     SER 6    18                                                      
REMARK 465     SER 6    19                                                      
REMARK 465     PRO 6    20                                                      
REMARK 465     PRO 6    21                                                      
REMARK 465     PRO 6    22                                                      
REMARK 465     SER 6    23                                                      
REMARK 465     SER 6    24                                                      
REMARK 465     ILE 6    25                                                      
REMARK 465     GLY 6    26                                                      
REMARK 465     ALA 6    27                                                      
REMARK 465     GLY 6    28                                                      
REMARK 465     PHE 6    29                                                      
REMARK 465     GLY 6    30                                                      
REMARK 465     SER 6    31                                                      
REMARK 465     SER 6    32                                                      
REMARK 465     SER 6    33                                                      
REMARK 465     GLY 6    34                                                      
REMARK 465     LEU 6    35                                                      
REMARK 465     ASP 6    36                                                      
REMARK 465     SER 6    37                                                      
REMARK 465     GLN 6    38                                                      
REMARK 465     ILE 6    39                                                      
REMARK 465     GLY 6    40                                                      
REMARK 465     SER 6    41                                                      
REMARK 465     ARG 6    42                                                      
REMARK 465     LEU 6    43                                                      
REMARK 465     HIS 6    44                                                      
REMARK 465     PHE 6    45                                                      
REMARK 465     PRO 6    46                                                      
REMARK 465     SER 6    47                                                      
REMARK 465     SER 6    48                                                      
REMARK 465     SER 6    49                                                      
REMARK 465     GLN 6    50                                                      
REMARK 465     PRO 6    51                                                      
REMARK 465     HIS 6    52                                                      
REMARK 465     VAL 6    53                                                      
REMARK 465     SER 6    54                                                      
REMARK 465     ASN 6    55                                                      
REMARK 465     SER 6    56                                                      
REMARK 465     GLN 6    57                                                      
REMARK 465     THR 6    58                                                      
REMARK 465     GLY 6    59                                                      
REMARK 465     PRO 6    60                                                      
REMARK 465     PHE 6    61                                                      
REMARK 465     VAL 6    62                                                      
REMARK 465     ASN 6    63                                                      
REMARK 465     ASP 6    64                                                      
REMARK 465     SER 6    65                                                      
REMARK 465     THR 6    66                                                      
REMARK 465     GLN 6    67                                                      
REMARK 465     PHE 6    68                                                      
REMARK 465     SER 6    69                                                      
REMARK 465     SER 6    70                                                      
REMARK 465     GLN 6    71                                                      
REMARK 465     ARG 6    72                                                      
REMARK 465     LEU 6    73                                                      
REMARK 465     GLN 6    74                                                      
REMARK 465     THR 6    75                                                      
REMARK 465     ASP 6    76                                                      
REMARK 465     GLY 6    77                                                      
REMARK 465     SER 6    78                                                      
REMARK 465     ALA 6    79                                                      
REMARK 465     THR 6    80                                                      
REMARK 465     ASN 6    81                                                      
REMARK 465     ASP 6    82                                                      
REMARK 465     MET 6    83                                                      
REMARK 465     GLU 6    84                                                      
REMARK 465     GLY 6    85                                                      
REMARK 465     ASN 6    86                                                      
REMARK 465     GLU 6    87                                                      
REMARK 465     PRO 6    88                                                      
REMARK 465     ALA 6    89                                                      
REMARK 465     ARG 6    90                                                      
REMARK 465     SER 6    91                                                      
REMARK 465     PHE 6    92                                                      
REMARK 465     LYS 6    93                                                      
REMARK 465     SER 6    94                                                      
REMARK 465     ARG 6    95                                                      
REMARK 465     ALA 6    96                                                      
REMARK 465     LEU 6    97                                                      
REMARK 465     ASN 6    98                                                      
REMARK 465     HIS 6    99                                                      
REMARK 465     VAL 6   100                                                      
REMARK 465     LYS 6   101                                                      
REMARK 465     LYS 6   102                                                      
REMARK 465     GLU 6   195                                                      
REMARK 465     LEU 6   196                                                      
REMARK 465     LEU 6   197                                                      
REMARK 465     ASN 6   198                                                      
REMARK 465     THR 6   199                                                      
REMARK 465     SER 6   200                                                      
REMARK 465     ASP 6   201                                                      
REMARK 465     SER 6   202                                                      
REMARK 465     LEU 6   203                                                      
REMARK 465     LYS 6   204                                                      
REMARK 465     ARG 6   205                                                      
REMARK 465     SER 6   206                                                      
REMARK 465     GLU 6   207                                                      
REMARK 465     GLY 6   208                                                      
REMARK 465     ASP 6   209                                                      
REMARK 465     GLU 6   210                                                      
REMARK 465     GLY 6   211                                                      
REMARK 465     GLN 6   212                                                      
REMARK 465     ALA 6   213                                                      
REMARK 465     ASP 6   214                                                      
REMARK 465     GLU 6   215                                                      
REMARK 465     ASP 6   216                                                      
REMARK 465     GLU 6   217                                                      
REMARK 465     GLN 6   218                                                      
REMARK 465     GLN 6   219                                                      
REMARK 465     ASP 6   220                                                      
REMARK 465     ASP 6   221                                                      
REMARK 465     ASP 6   222                                                      
REMARK 465     MET 6   223                                                      
REMARK 465     ASN 6   224                                                      
REMARK 465     GLY 6   225                                                      
REMARK 465     SER 6   226                                                      
REMARK 465     SER 6   227                                                      
REMARK 465     LEU 6   228                                                      
REMARK 465     PRO 6   229                                                      
REMARK 465     ARG 6   230                                                      
REMARK 465     ASP 6   231                                                      
REMARK 465     SER 6   232                                                      
REMARK 465     GLY 6   233                                                      
REMARK 465     SER 6   234                                                      
REMARK 465     SER 6   235                                                      
REMARK 465     ALA 6   236                                                      
REMARK 465     ALA 6   237                                                      
REMARK 465     PRO 6   238                                                      
REMARK 465     GLY 6   239                                                      
REMARK 465     ASN 6   240                                                      
REMARK 465     GLY 6   241                                                      
REMARK 465     THR 6   242                                                      
REMARK 465     SER 6   243                                                      
REMARK 465     ALA 6   244                                                      
REMARK 465     MET 6   245                                                      
REMARK 465     ALA 6   246                                                      
REMARK 465     THR 6   247                                                      
REMARK 465     ARG 6   248                                                      
REMARK 465     SER 6   249                                                      
REMARK 465     ILE 6   250                                                      
REMARK 465     THR 6   251                                                      
REMARK 465     THR 6   252                                                      
REMARK 465     SER 6   253                                                      
REMARK 465     THR 6   254                                                      
REMARK 465     SER 6   255                                                      
REMARK 465     PRO 6   256                                                      
REMARK 465     GLU 6   257                                                      
REMARK 465     GLN 6   258                                                      
REMARK 465     THR 6   259                                                      
REMARK 465     LEU 6   421                                                      
REMARK 465     ASP 6   422                                                      
REMARK 465     THR 6   423                                                      
REMARK 465     ARG 6   424                                                      
REMARK 465     GLY 6   425                                                      
REMARK 465     ILE 6   426                                                      
REMARK 465     SER 6   427                                                      
REMARK 465     LYS 6   428                                                      
REMARK 465     THR 6   429                                                      
REMARK 465     THR 6   430                                                      
REMARK 465     GLU 6   431                                                      
REMARK 465     GLY 6   432                                                      
REMARK 465     LEU 6   433                                                      
REMARK 465     ASN 6   434                                                      
REMARK 465     SER 6   435                                                      
REMARK 465     GLY 6   436                                                      
REMARK 465     VAL 6   437                                                      
REMARK 465     THR 6   438                                                      
REMARK 465     GLY 6   439                                                      
REMARK 465     LEU 6   440                                                      
REMARK 465     ARG 6   441                                                      
REMARK 465     SER 6   442                                                      
REMARK 465     LEU 6   443                                                      
REMARK 465     SER 6   464                                                      
REMARK 465     ASN 6   465                                                      
REMARK 465     ILE 6   466                                                      
REMARK 465     GLY 6   467                                                      
REMARK 465     ALA 6   468                                                      
REMARK 465     SER 6   469                                                      
REMARK 465     SER 6   470                                                      
REMARK 465     PRO 6   471                                                      
REMARK 465     ASP 6   472                                                      
REMARK 465     ALA 6   473                                                      
REMARK 465     ASN 6   474                                                      
REMARK 465     SER 6   475                                                      
REMARK 465     ASN 6   476                                                      
REMARK 465     ASN 6   477                                                      
REMARK 465     ARG 6   478                                                      
REMARK 465     GLU 6   479                                                      
REMARK 465     THR 6   480                                                      
REMARK 465     GLU 6   481                                                      
REMARK 465     LEU 6   482                                                      
REMARK 465     GLN 6   483                                                      
REMARK 465     MET 6   484                                                      
REMARK 465     ALA 6   485                                                      
REMARK 465     ALA 6   486                                                      
REMARK 465     ASN 6   487                                                      
REMARK 465     LEU 6   488                                                      
REMARK 465     GLN 6   489                                                      
REMARK 465     ALA 6   490                                                      
REMARK 465     ASN 6   491                                                      
REMARK 465     ASN 6   492                                                      
REMARK 465     VAL 6   493                                                      
REMARK 465     TYR 6   494                                                      
REMARK 465     GLN 6   495                                                      
REMARK 465     ASP 6   496                                                      
REMARK 465     ASN 6   497                                                      
REMARK 465     GLU 6   498                                                      
REMARK 465     ARG 6   499                                                      
REMARK 465     ASP 6   500                                                      
REMARK 465     GLN 6   501                                                      
REMARK 465     GLU 6   502                                                      
REMARK 465     VAL 6   503                                                      
REMARK 465     PHE 6   504                                                      
REMARK 465     LEU 6   505                                                      
REMARK 465     ASN 6   506                                                      
REMARK 465     SER 6   507                                                      
REMARK 465     LEU 6   508                                                      
REMARK 465     SER 6   509                                                      
REMARK 465     ASP 6   841                                                      
REMARK 465     ASP 6   842                                                      
REMARK 465     VAL 6   843                                                      
REMARK 465     GLU 6   844                                                      
REMARK 465     MET 6   845                                                      
REMARK 465     ASP 6   846                                                      
REMARK 465     GLU 6   847                                                      
REMARK 465     GLU 6   848                                                      
REMARK 465     PHE 6   849                                                      
REMARK 465     ASP 6   850                                                      
REMARK 465     ASN 6   851                                                      
REMARK 465     ILE 6   852                                                      
REMARK 465     GLU 6   853                                                      
REMARK 465     SER 6   854                                                      
REMARK 465     GLN 6   855                                                      
REMARK 465     SER 6   856                                                      
REMARK 465     HIS 6   857                                                      
REMARK 465     ALA 6   858                                                      
REMARK 465     ALA 6   859                                                      
REMARK 465     SER 6   860                                                      
REMARK 465     GLY 6   861                                                      
REMARK 465     ASN 6   862                                                      
REMARK 465     ASN 6   863                                                      
REMARK 465     ASP 6   864                                                      
REMARK 465     ASP 6   865                                                      
REMARK 465     ASN 6   866                                                      
REMARK 465     ASP 6   867                                                      
REMARK 465     ASP 6   868                                                      
REMARK 465     GLY 6   869                                                      
REMARK 465     THR 6   870                                                      
REMARK 465     GLY 6   871                                                      
REMARK 465     SER 6   872                                                      
REMARK 465     GLY 6   873                                                      
REMARK 465     VAL 6   874                                                      
REMARK 465     ILE 6   875                                                      
REMARK 465     THR 6   876                                                      
REMARK 465     SER 6   877                                                      
REMARK 465     GLU 6   878                                                      
REMARK 465     PRO 6   879                                                      
REMARK 465     PRO 6   880                                                      
REMARK 465     ALA 6   881                                                      
REMARK 465     ASP 6   882                                                      
REMARK 465     ILE 6   883                                                      
REMARK 465     GLU 6   884                                                      
REMARK 465     GLU 6   885                                                      
REMARK 465     GLY 6   886                                                      
REMARK 465     GLN 6   887                                                      
REMARK 465     SER 6   888                                                      
REMARK 465     GLU 6   889                                                      
REMARK 465     ALA 6   890                                                      
REMARK 465     THR 6   891                                                      
REMARK 465     ALA 6   892                                                      
REMARK 465     ARG 6   893                                                      
REMARK 465     PRO 6   894                                                      
REMARK 465     GLY 6   895                                                      
REMARK 465     THR 6   896                                                      
REMARK 465     SER 6   897                                                      
REMARK 465     GLU 6   898                                                      
REMARK 465     LYS 6   899                                                      
REMARK 465     LYS 6   900                                                      
REMARK 465     LYS 6   901                                                      
REMARK 465     THR 6   902                                                      
REMARK 465     THR 6   903                                                      
REMARK 465     VAL 6   904                                                      
REMARK 465     THR 6   905                                                      
REMARK 465     TYR 6   906                                                      
REMARK 465     ASP 6   907                                                      
REMARK 465     LYS 6   908                                                      
REMARK 465     TYR 6   909                                                      
REMARK 465     VAL 6   910                                                      
REMARK 465     SER 6   911                                                      
REMARK 465     MET 6   912                                                      
REMARK 465     MET 6   913                                                      
REMARK 465     ASN 6   914                                                      
REMARK 465     MET 6   915                                                      
REMARK 465     ILE 6   916                                                      
REMARK 465     VAL 6   917                                                      
REMARK 465     ARG 6   918                                                      
REMARK 465     LYS 6   919                                                      
REMARK 465     ILE 6   920                                                      
REMARK 465     ALA 6   921                                                      
REMARK 465     GLU 6   922                                                      
REMARK 465     VAL 6   923                                                      
REMARK 465     ASP 6   924                                                      
REMARK 465     ARG 6   925                                                      
REMARK 465     GLU 6   926                                                      
REMARK 465     GLY 6   927                                                      
REMARK 465     ALA 6   928                                                      
REMARK 465     GLU 6   929                                                      
REMARK 465     GLU 6   930                                                      
REMARK 465     LEU 6   931                                                      
REMARK 465     THR 6   932                                                      
REMARK 465     ALA 6   933                                                      
REMARK 465     VAL 6   934                                                      
REMARK 465     ASP 6   935                                                      
REMARK 465     ILE 6   936                                                      
REMARK 465     VAL 6   937                                                      
REMARK 465     ASP 6   938                                                      
REMARK 465     TRP 6   939                                                      
REMARK 465     TYR 6   940                                                      
REMARK 465     LEU 6   941                                                      
REMARK 465     LEU 6   942                                                      
REMARK 465     GLN 6   943                                                      
REMARK 465     LYS 6   944                                                      
REMARK 465     GLU 6   945                                                      
REMARK 465     ASN 6   946                                                      
REMARK 465     ASP 6   947                                                      
REMARK 465     LEU 6   948                                                      
REMARK 465     GLY 6   949                                                      
REMARK 465     SER 6   950                                                      
REMARK 465     LEU 6   951                                                      
REMARK 465     ALA 6   952                                                      
REMARK 465     GLU 6   953                                                      
REMARK 465     TYR 6   954                                                      
REMARK 465     TRP 6   955                                                      
REMARK 465     GLU 6   956                                                      
REMARK 465     GLU 6   957                                                      
REMARK 465     ARG 6   958                                                      
REMARK 465     ARG 6   959                                                      
REMARK 465     LEU 6   960                                                      
REMARK 465     ALA 6   961                                                      
REMARK 465     PHE 6   962                                                      
REMARK 465     LYS 6   963                                                      
REMARK 465     VAL 6   964                                                      
REMARK 465     ILE 6   965                                                      
REMARK 465     LYS 6   966                                                      
REMARK 465     ARG 6   967                                                      
REMARK 465     LEU 6   968                                                      
REMARK 465     VAL 6   969                                                      
REMARK 465     LYS 6   970                                                      
REMARK 465     ASP 6   971                                                      
REMARK 465     ARG 6   972                                                      
REMARK 465     ILE 6   973                                                      
REMARK 465     LEU 6   974                                                      
REMARK 465     MET 6   975                                                      
REMARK 465     GLU 6   976                                                      
REMARK 465     ILE 6   977                                                      
REMARK 465     HIS 6   978                                                      
REMARK 465     GLY 6   979                                                      
REMARK 465     THR 6   980                                                      
REMARK 465     ARG 6   981                                                      
REMARK 465     HIS 6   982                                                      
REMARK 465     ASN 6   983                                                      
REMARK 465     LEU 6   984                                                      
REMARK 465     ARG 6   985                                                      
REMARK 465     ASP 6   986                                                      
REMARK 465     LEU 6   987                                                      
REMARK 465     GLU 6   988                                                      
REMARK 465     ASN 6   989                                                      
REMARK 465     GLU 6   990                                                      
REMARK 465     GLU 6   991                                                      
REMARK 465     ASN 6   992                                                      
REMARK 465     GLU 6   993                                                      
REMARK 465     ASN 6   994                                                      
REMARK 465     ASN 6   995                                                      
REMARK 465     LYS 6   996                                                      
REMARK 465     THR 6   997                                                      
REMARK 465     VAL 6   998                                                      
REMARK 465     TYR 6   999                                                      
REMARK 465     VAL 6  1000                                                      
REMARK 465     ILE 6  1001                                                      
REMARK 465     HIS 6  1002                                                      
REMARK 465     PRO 6  1003                                                      
REMARK 465     ASN 6  1004                                                      
REMARK 465     CYS 6  1005                                                      
REMARK 465     GLU 6  1006                                                      
REMARK 465     VAL 6  1007                                                      
REMARK 465     LEU 6  1008                                                      
REMARK 465     ASP 6  1009                                                      
REMARK 465     GLN 6  1010                                                      
REMARK 465     LEU 6  1011                                                      
REMARK 465     GLU 6  1012                                                      
REMARK 465     PRO 6  1013                                                      
REMARK 465     GLN 6  1014                                                      
REMARK 465     ASP 6  1015                                                      
REMARK 465     SER 6  1016                                                      
REMARK 465     SER 6  1017                                                      
REMARK 465     THR 7    32                                                      
REMARK 465     LEU 7    33                                                      
REMARK 465     SER 7    34                                                      
REMARK 465     SER 7    35                                                      
REMARK 465     ASP 7    36                                                      
REMARK 465     ALA 7    37                                                      
REMARK 465     THR 7    38                                                      
REMARK 465     ARG 7    39                                                      
REMARK 465     ASN 7    40                                                      
REMARK 465     GLU 7    41                                                      
REMARK 465     ASN 7    42                                                      
REMARK 465     GLU 7    43                                                      
REMARK 465     ASP 7    44                                                      
REMARK 465     GLU 7    45                                                      
REMARK 465     ASN 7    46                                                      
REMARK 465     LEU 7    47                                                      
REMARK 465     ASP 7    48                                                      
REMARK 465     ALA 7    49                                                      
REMARK 465     GLU 7    50                                                      
REMARK 465     ASN 7    51                                                      
REMARK 465     ILE 7    52                                                      
REMARK 465     GLU 7    53                                                      
REMARK 465     GLN 7    54                                                      
REMARK 465     HIS 7    55                                                      
REMARK 465     LEU 7    56                                                      
REMARK 465     LEU 7    57                                                      
REMARK 465     GLU 7    58                                                      
REMARK 465     ASN 7   159                                                      
REMARK 465     GLU 7   160                                                      
REMARK 465     ILE 7   161                                                      
REMARK 465     ARG 7   162                                                      
REMARK 465     SER 7   163                                                      
REMARK 465     GLU 7   164                                                      
REMARK 465     ASN 7   165                                                      
REMARK 465     LEU 7   166                                                      
REMARK 465     MET 7   167                                                      
REMARK 465     ASP 7   168                                                      
REMARK 465     THR 7   169                                                      
REMARK 465     THR 7   170                                                      
REMARK 465     MET 7   171                                                      
REMARK 465     ASP 7   172                                                      
REMARK 465     PRO 7   173                                                      
REMARK 465     PRO 7   174                                                      
REMARK 465     SER 7   175                                                      
REMARK 465     SER 7   176                                                      
REMARK 465     MET 7   177                                                      
REMARK 465     ASN 7   178                                                      
REMARK 465     ASP 7   179                                                      
REMARK 465     ALA 7   180                                                      
REMARK 465     LEU 7   181                                                      
REMARK 465     ARG 7   182                                                      
REMARK 465     GLU 7   183                                                      
REMARK 465     VAL 7   184                                                      
REMARK 465     VAL 7   185                                                      
REMARK 465     GLU 7   186                                                      
REMARK 465     ASP 7   187                                                      
REMARK 465     GLU 7   188                                                      
REMARK 465     LYS 7   217                                                      
REMARK 465     LYS 7   218                                                      
REMARK 465     ALA 7   219                                                      
REMARK 465     LYS 7   387                                                      
REMARK 465     PHE 7   388                                                      
REMARK 465     ALA 7   389                                                      
REMARK 465     SER 7   390                                                      
REMARK 465     PHE 7   391                                                      
REMARK 465     SER 7   392                                                      
REMARK 465     GLU 7   730                                                      
REMARK 465     THR 7   731                                                      
REMARK 465     ASN 7   732                                                      
REMARK 465     LYS 7   733                                                      
REMARK 465     SER 7   734                                                      
REMARK 465     LYS 7   735                                                      
REMARK 465     GLU 7   736                                                      
REMARK 465     ASP 7   737                                                      
REMARK 465     GLU 7   738                                                      
REMARK 465     SER 7   739                                                      
REMARK 465     PRO 7   740                                                      
REMARK 465     THR 7   741                                                      
REMARK 465     THR 7   742                                                      
REMARK 465     LYS 7   743                                                      
REMARK 465     ILE 7   744                                                      
REMARK 465     PHE 7   745                                                      
REMARK 465     THR 7   746                                                      
REMARK 465     ILE 7   747                                                      
REMARK 465     ILE 7   748                                                      
REMARK 465     LYS 7   749                                                      
REMARK 465     LYS 7   750                                                      
REMARK 465     MET 7   751                                                      
REMARK 465     LEU 7   752                                                      
REMARK 465     GLN 7   753                                                      
REMARK 465     GLU 7   754                                                      
REMARK 465     THR 7   755                                                      
REMARK 465     GLY 7   756                                                      
REMARK 465     LYS 7   757                                                      
REMARK 465     ASN 7   758                                                      
REMARK 465     THR 7   759                                                      
REMARK 465     LEU 7   760                                                      
REMARK 465     SER 7   761                                                      
REMARK 465     TYR 7   762                                                      
REMARK 465     GLU 7   763                                                      
REMARK 465     ASN 7   764                                                      
REMARK 465     ILE 7   765                                                      
REMARK 465     VAL 7   766                                                      
REMARK 465     LYS 7   767                                                      
REMARK 465     THR 7   768                                                      
REMARK 465     VAL 7   769                                                      
REMARK 465     ARG 7   770                                                      
REMARK 465     LEU 7   771                                                      
REMARK 465     ARG 7   772                                                      
REMARK 465     GLY 7   773                                                      
REMARK 465     PHE 7   774                                                      
REMARK 465     THR 7   775                                                      
REMARK 465     MET 7   776                                                      
REMARK 465     LEU 7   777                                                      
REMARK 465     GLN 7   778                                                      
REMARK 465     LEU 7   779                                                      
REMARK 465     SER 7   780                                                      
REMARK 465     ASN 7   781                                                      
REMARK 465     CYS 7   782                                                      
REMARK 465     ILE 7   783                                                      
REMARK 465     GLN 7   784                                                      
REMARK 465     GLU 7   785                                                      
REMARK 465     TYR 7   786                                                      
REMARK 465     SER 7   787                                                      
REMARK 465     TYR 7   788                                                      
REMARK 465     LEU 7   789                                                      
REMARK 465     ASN 7   790                                                      
REMARK 465     VAL 7   791                                                      
REMARK 465     TRP 7   792                                                      
REMARK 465     HIS 7   793                                                      
REMARK 465     LEU 7   794                                                      
REMARK 465     ILE 7   795                                                      
REMARK 465     ASN 7   796                                                      
REMARK 465     GLU 7   797                                                      
REMARK 465     GLY 7   798                                                      
REMARK 465     ASN 7   799                                                      
REMARK 465     THR 7   800                                                      
REMARK 465     LEU 7   801                                                      
REMARK 465     LYS 7   802                                                      
REMARK 465     PHE 7   803                                                      
REMARK 465     VAL 7   804                                                      
REMARK 465     ASP 7   805                                                      
REMARK 465     ASP 7   806                                                      
REMARK 465     GLY 7   807                                                      
REMARK 465     THR 7   808                                                      
REMARK 465     MET 7   809                                                      
REMARK 465     ASP 7   810                                                      
REMARK 465     THR 7   811                                                      
REMARK 465     ASP 7   812                                                      
REMARK 465     GLN 7   813                                                      
REMARK 465     GLU 7   814                                                      
REMARK 465     ASP 7   815                                                      
REMARK 465     SER 7   816                                                      
REMARK 465     LEU 7   817                                                      
REMARK 465     VAL 7   818                                                      
REMARK 465     SER 7   819                                                      
REMARK 465     THR 7   820                                                      
REMARK 465     PRO 7   821                                                      
REMARK 465     LYS 7   822                                                      
REMARK 465     LEU 7   823                                                      
REMARK 465     ALA 7   824                                                      
REMARK 465     PRO 7   825                                                      
REMARK 465     GLN 7   826                                                      
REMARK 465     THR 7   827                                                      
REMARK 465     THR 7   828                                                      
REMARK 465     ALA 7   829                                                      
REMARK 465     SER 7   830                                                      
REMARK 465     ALA 7   831                                                      
REMARK 465     ASN 7   832                                                      
REMARK 465     VAL 7   833                                                      
REMARK 465     SER 7   834                                                      
REMARK 465     ALA 7   835                                                      
REMARK 465     GLN 7   836                                                      
REMARK 465     ASP 7   837                                                      
REMARK 465     SER 7   838                                                      
REMARK 465     ASP 7   839                                                      
REMARK 465     ILE 7   840                                                      
REMARK 465     ASP 7   841                                                      
REMARK 465     LEU 7   842                                                      
REMARK 465     GLN 7   843                                                      
REMARK 465     ASP 7   844                                                      
REMARK 465     ALA 7   845                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU C 119    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 224    CD   CE   NZ                                        
REMARK 470     GLN 2 353    CG   CD   OE1  NE2                                  
REMARK 470     ASP 2 354    CG   OD1  OD2                                       
REMARK 470     SER 2 355    OG                                                  
REMARK 470     ASN 2 356    CG   OD1  ND2                                       
REMARK 470     GLU 2 357    CG   CD   OE1  OE2                                  
REMARK 470     GLU 2 358    CG   CD   OE1  OE2                                  
REMARK 470     ILE 2 359    CG1  CG2  CD1                                       
REMARK 470     ARG 2 360    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE 2 361    CG1  CG2  CD1                                       
REMARK 470     SER 2 362    OG                                                  
REMARK 470     PHE 2 363    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     CYS 2 364    SG                                                  
REMARK 470     THR 2 365    OG1  CG2                                            
REMARK 470     ASN 2 366    CG   OD1  ND2                                       
REMARK 470     CYS 2 367    SG                                                  
REMARK 470     LYS 2 368    CG   CD   CE   NZ                                   
REMARK 470     SER 2 369    OG                                                  
REMARK 470     LYS 2 370    CG   CD   CE   NZ                                   
REMARK 470     PRO 2 372    CG   CD                                             
REMARK 470     ILE 4 374    CG1  CG2  CD1                                       
REMARK 470     ASP 4 375    CG   OD1  OD2                                       
REMARK 470     CYS 4 376    SG                                                  
REMARK 470     ASN 4 377    CG   OD1  ND2                                       
REMARK 470     GLU 4 378    CG   CD   OE1  OE2                                  
REMARK 470     PRO 4 379    CG   CD                                             
REMARK 470     ASN 4 380    CG   OD1  ND2                                       
REMARK 470     SER 4 381    OG                                                  
REMARK 470     THR 5 325    CG2                                                 
REMARK 470     PRO 5 326    CD                                                  
REMARK 470     VAL 5 337    CG1                                                 
REMARK 470     THR 5 339    CG2                                                 
REMARK 470     SER 6 308    OG                                                  
REMARK 470     PHE 6 309    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR 6 310    OG1  CG2                                            
REMARK 470     CYS 6 311    SG                                                  
REMARK 470     ASP 6 312    CG   OD1  OD2                                       
REMARK 470     MET 6 313    CG   SD   CE                                        
REMARK 470     CYS 6 314    SG                                                  
REMARK 470     ARG 6 315    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE 6 317    CG1  CG2  CD1                                       
REMARK 470     VAL 6 318    CG1  CG2                                            
REMARK 470     ASP 6 319    CG   OD1  OD2                                       
REMARK 470     ASN 6 320    CG   OD1  ND2                                       
REMARK 470     VAL 6 321    CG1  CG2                                            
REMARK 470     GLU 6 322    CG   CD   OE1  OE2                                  
REMARK 470     GLN 6 323    CG   CD   OE1  NE2                                  
REMARK 470     SER 6 324    OG                                                  
REMARK 470     PHE 6 325    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS 6 326    CG   CD   CE   NZ                                   
REMARK 470     TYR 6 327    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     THR 6 328    OG1  CG2                                            
REMARK 470     GLU 6 329    CG   CD   OE1  OE2                                  
REMARK 470     PRO 6 330    CG   CD                                             
REMARK 470     THR 6 331    OG1  CG2                                            
REMARK 470     PHE 6 332    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     CYS 6 333    SG                                                  
REMARK 470     PRO 6 334    CG   CD                                             
REMARK 470     ASN 6 335    CG   OD1  ND2                                       
REMARK 470     PRO 6 336    CG   CD                                             
REMARK 470     SER 6 337    OG                                                  
REMARK 470     CYS 6 338    SG                                                  
REMARK 470     GLU 6 339    CG   CD   OE1  OE2                                  
REMARK 470     ASN 6 340    CG   OD1  ND2                                       
REMARK 470     ARG 6 341    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE 6 343    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TRP 6 344    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP 6 344    CZ3  CH2                                            
REMARK 470     THR 6 345    OG1  CG2                                            
REMARK 470     LEU 6 346    CG   CD1  CD2                                       
REMARK 470     GLU 6 616    CG   CD   OE1  OE2                                  
REMARK 470     GLU 6 617    CG   CD   OE1  OE2                                  
REMARK 470     ASP 6 620    CG   OD1  OD2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OD1  ASN 5   302     CZ   ARG 5   324              1.64            
REMARK 500   OD1  ASN 5   302     NE   ARG 5   324              1.93            
REMARK 500   OD1  ASN 5   302     NH1  ARG 5   324              2.00            
REMARK 500   O    ILE 5   244     OG   SER 5   248              2.03            
REMARK 500   N    ILE 2   585     O    LYS 2   587              2.03            
REMARK 500   N    ILE 2   631     O    SER 5   445              2.06            
REMARK 500   O    ASP 3    23     N    ARG 3    27              2.07            
REMARK 500   O    LEU 7   139     N    ILE 7   142              2.09            
REMARK 500   OG   SER E    32     O    VAL E    84              2.10            
REMARK 500   O    ASN C    86     NH1  ARG 3   104              2.10            
REMARK 500   N    VAL 2   539     O    ILE 2   646              2.11            
REMARK 500   N    GLY E    85     O    LEU E   123              2.11            
REMARK 500   O    LYS 2   601     NH2  ARG 2   771              2.11            
REMARK 500   O    ASP 6   576     OG1  THR 6   579              2.11            
REMARK 500   O    ALA 6   703     N    SER 6   707              2.12            
REMARK 500   O    ILE 6   533     OH   TYR 6   587              2.12            
REMARK 500   O    SER B   113     ND2  ASN B   172              2.12            
REMARK 500   N    LEU 2   542     O    CYS 2   681              2.12            
REMARK 500   OG1  THR 5   293     O    GLN 5   334              2.12            
REMARK 500   O    SER 6   308     N    ASN 6   347              2.13            
REMARK 500   OE2  GLU 2   243     OG   SER 2   298              2.13            
REMARK 500   N    GLY 7   236     O    PHE 7   355              2.13            
REMARK 500   O    PHE 2   300     OG1  THR 2   302              2.13            
REMARK 500   O    ASN 5    33     N    GLU 5    37              2.13            
REMARK 500   O    LYS 4   348     N    SER 4   383              2.14            
REMARK 500   N    ILE B    25     O    VAL B    71              2.14            
REMARK 500   O    VAL 3   186     N    GLY 3   289              2.14            
REMARK 500   O    GLU 2   671     N    SER 2   675              2.14            
REMARK 500   O    HIS 3   201     N    HIS 3   210              2.14            
REMARK 500   O    ALA 3    19     N    ASP 3    23              2.14            
REMARK 500   N    SER 2   315     O    TYR 2   430              2.14            
REMARK 500   OP2   DT F    21     OG   SER 3   438              2.14            
REMARK 500   OD2  ASP 6   355     N    GLY 6   383              2.15            
REMARK 500   N    CYS 2   604     O    SER 2   645              2.15            
REMARK 500   OH   TYR 5    46     N    ASN 5    64              2.15            
REMARK 500   O    PHE E   605     N    PHE E   609              2.15            
REMARK 500   O    LEU B   141     N    ILE B   145              2.15            
REMARK 500   O    THR 2   638     N    SER 5   445              2.15            
REMARK 500   OG1  THR E   509     OH   TYR E   539              2.15            
REMARK 500   OG   SER 5   180     OG   SER 5   247              2.16            
REMARK 500   OG   SER 2   241     OD2  ASP 2   413              2.16            
REMARK 500   O    MET E   362     N    MET E   366              2.16            
REMARK 500   O    ALA 7   259     N    SER 7   301              2.16            
REMARK 500   O    LEU 6   830     OG   SER 6   834              2.17            
REMARK 500   O    THR 3   187     OG1  THR 3   257              2.17            
REMARK 500   O    GLU 4   267     OG   SER 4   270              2.17            
REMARK 500   O    ARG 3   169     NH2  ARG 3   272              2.17            
REMARK 500   N6    DA F     9     O4    DT G    10              2.17            
REMARK 500   O    HIS D   231     N    ALA D   292              2.18            
REMARK 500   O    TYR 2   218     OG   SER 2   225              2.18            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      78 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    GLY A 106   N   -  CA  -  C   ANGL. DEV. =  18.2 DEGREES          
REMARK 500    CYS 2 367   C   -  N   -  CA  ANGL. DEV. =  16.2 DEGREES          
REMARK 500    PRO 2 372   C   -  N   -  CA  ANGL. DEV. =  18.5 DEGREES          
REMARK 500    GLY 7 369   N   -  CA  -  C   ANGL. DEV. =  19.9 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    TYR A   2      -73.96   -118.34                                   
REMARK 500    ALA A  21      -71.03    -58.00                                   
REMARK 500    VAL A  27     -119.15     52.49                                   
REMARK 500    MET A  31      165.10    175.70                                   
REMARK 500    LEU A  60      -75.58   -112.92                                   
REMARK 500    ASP A 108      -67.95   -147.82                                   
REMARK 500    LEU A 109       73.64     53.03                                   
REMARK 500    PHE A 115      -14.74     73.69                                   
REMARK 500    GLN A 117       66.67     61.71                                   
REMARK 500    THR A 120     -115.25     50.81                                   
REMARK 500    VAL A 147      -61.77   -129.53                                   
REMARK 500    SER A 159      158.83    178.81                                   
REMARK 500    LYS A 169       37.40     39.49                                   
REMARK 500    TYR A 178     -108.26     57.92                                   
REMARK 500    ASN A 182       70.85     57.81                                   
REMARK 500    GLN A 206      -74.81   -119.72                                   
REMARK 500    ALA B   5     -112.86     57.22                                   
REMARK 500    THR B  54     -137.67     53.01                                   
REMARK 500    THR B  55      -76.47   -123.97                                   
REMARK 500    LYS B  58       -7.32     73.26                                   
REMARK 500    ASP B 110      -66.91    -94.07                                   
REMARK 500    SER B 113     -137.49     60.32                                   
REMARK 500    TRP B 117      -24.65     77.42                                   
REMARK 500    LYS B 129      -59.55   -126.47                                   
REMARK 500    ALA B 130       -6.50    -57.51                                   
REMARK 500    HIS B 139       28.19     47.10                                   
REMARK 500    GLU B 140      -79.46   -121.86                                   
REMARK 500    ASP B 171     -134.72     54.26                                   
REMARK 500    PHE B 184      -71.81    -57.97                                   
REMARK 500    ILE B 188      -73.66    -80.65                                   
REMARK 500    PRO C  17       76.85    -68.39                                   
REMARK 500    PRO C  34       72.19    -67.99                                   
REMARK 500    LEU C  74       70.75     58.12                                   
REMARK 500    THR C  90      -72.79    -83.20                                   
REMARK 500    ASN C 101      -61.88   -128.36                                   
REMARK 500    PHE C 104      -69.48   -130.39                                   
REMARK 500    LEU C 107      -64.39    -91.07                                   
REMARK 500    VAL C 123      -70.83    -88.03                                   
REMARK 500    SER C 163      -78.18   -126.52                                   
REMARK 500    LEU D 126      -70.17    -56.42                                   
REMARK 500    SER D 167      -72.65   -105.80                                   
REMARK 500    LEU D 171     -143.76     52.16                                   
REMARK 500    SER D 197      -75.66    -89.30                                   
REMARK 500    LYS D 200      -59.97   -136.15                                   
REMARK 500    ASN D 210     -179.97    169.09                                   
REMARK 500    VAL D 216      -58.62   -124.37                                   
REMARK 500    MET D 218       74.63     55.78                                   
REMARK 500    ILE D 219     -112.59     55.41                                   
REMARK 500    THR D 259     -136.69     66.17                                   
REMARK 500    ILE D 260       73.43     49.72                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     373 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ASP A  160     VAL A  161                  -38.09                    
REMARK 500 VAL D  258     THR D  259                   33.42                    
REMARK 500 LEU 3  428     ALA 3  429                   37.31                    
REMARK 500 ARG 4  373     ILE 4  374                   30.20                    
REMARK 500 ASP 4  408     GLY 4  409                   42.94                    
REMARK 500 GLU 6  133     LYS 6  134                  -37.50                    
REMARK 500 CYS 6  333     PRO 6  334                  149.03                    
REMARK 500 VAL 6  560     GLU 6  561                  -30.68                    
REMARK 500 LYS 7  486     GLY 7  487                  -30.41                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP 2 901                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP 3 1001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP 5 801                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8518   RELATED DB: EMDB                              
REMARK 900 STRUCTURE OF EUKARYOTIC CMG HELICASE AT A REPLICATION FORK           
DBREF  5U8S A    1   208  UNP    Q12488   PSF1_YEAST       1    208             
DBREF  5U8S B    1   213  UNP    P40359   PSF2_YEAST       1    213             
DBREF  5U8S C    1   194  UNP    Q12146   PSF3_YEAST       1    194             
DBREF  5U8S D    1   294  UNP    Q03406   SLD5_YEAST       1    294             
DBREF  5U8S E    1   650  UNP    Q08032   CDC45_YEAST      1    650             
DBREF  5U8S F    1    26  PDB    5U8S     5U8S             1     26             
DBREF  5U8S G    5    18  PDB    5U8S     5U8S             5     18             
DBREF  5U8S 2    1   868  UNP    P29469   MCM2_YEAST       1    868             
DBREF  5U8S 3    1   971  UNP    P24279   MCM3_YEAST       1    971             
DBREF  5U8S 4    1   933  UNP    P30665   MCM4_YEAST       1    933             
DBREF  5U8S 5    1   775  UNP    P29496   MCM5_YEAST       1    775             
DBREF  5U8S 6    1  1017  UNP    P53091   MCM6_YEAST       1   1017             
DBREF  5U8S 7    1   845  UNP    P38132   MCM7_YEAST       1    845             
SEQADV 5U8S VAL 4  469  UNP  P30665    LYS   468 CONFLICT                       
SEQADV 5U8S SER 4  470  UNP  P30665    VAL   469 CONFLICT                       
SEQRES   1 A  208  MET TYR GLY ASP LEU GLY ASN LYS LEU VAL LEU GLU ALA          
SEQRES   2 A  208  LYS ARG THR LYS GLN LEU TYR ALA ARG SER ASN GLN ASP          
SEQRES   3 A  208  VAL ASN LEU PRO MET TYR HIS GLU ASP ILE ILE ARG ASN          
SEQRES   4 A  208  ILE LEU LYS GLU VAL SER ASN LEU ARG LYS ASN THR GLU          
SEQRES   5 A  208  TYR LEU LYS GLU GLN GLN GLN LEU GLY MET LEU ASP ASP          
SEQRES   6 A  208  LYS VAL ALA LYS CYS GLN TYR PHE VAL THR LEU LEU CYS          
SEQRES   7 A  208  MET GLU ARG ASN LYS ARG CYS LEU LEU ALA TYR GLN ARG          
SEQRES   8 A  208  LEU ARG THR ASP ILE LEU ASP SER MET ALA TRP ASN ASN          
SEQRES   9 A  208  ASN GLY LEU ASP LEU MET SER SER ILE THR PHE SER GLN          
SEQRES  10 A  208  GLN ASP THR ASN ASN LEU SER HIS GLN GLU GLN GLU TYR          
SEQRES  11 A  208  LEU LYS GLU TYR CYS ASP LEU ILE THR ASP LEU LYS SER          
SEQRES  12 A  208  GLY ASP LEU VAL ASP ILE ASP LEU SER GLY SER LEU VAL          
SEQRES  13 A  208  PRO PRO SER ASP VAL PHE ILE ASP VAL ARG VAL LEU LYS          
SEQRES  14 A  208  ASP ALA GLY GLU ILE GLN THR GLU TYR GLY VAL PHE ASN          
SEQRES  15 A  208  LEU ILE LYS ASP SER GLN PHE PHE VAL ARG GLN SER ASP          
SEQRES  16 A  208  VAL GLU ARG LEU ILE GLN GLN GLY TYR LEU GLN LYS ILE          
SEQRES   1 B  213  MET SER LEU PRO ALA HIS LEU GLN GLN THR PHE SER PRO          
SEQRES   2 B  213  GLU GLU ILE GLN PHE ILE VAL GLU ASN GLU PRO ILE LYS          
SEQRES   3 B  213  ILE PHE PRO ARG ILE THR THR ARG GLN LYS ILE ARG GLY          
SEQRES   4 B  213  ASP ASP ARG GLY THR GLY ASN HIS THR ARG TRP GLN LEU          
SEQRES   5 B  213  ILE THR THR ASP ASP LYS ALA LEU ASN ASN MET VAL ALA          
SEQRES   6 B  213  MET ARG SER THR GLU VAL VAL LEU TRP ILE ALA LEU LEU          
SEQRES   7 B  213  LEU LYS GLN GLN SER LYS CYS SER ILE VAL ALA PRO GLN          
SEQRES   8 B  213  TRP LEU THR THR LYS GLU LEU ASP ARG LYS ILE GLN TYR          
SEQRES   9 B  213  GLU LYS THR HIS PRO ASP ARG PHE SER GLU LEU PRO TRP          
SEQRES  10 B  213  ASN TRP LEU VAL LEU ALA ARG ILE LEU PHE ASN LYS ALA          
SEQRES  11 B  213  LYS ASP ASP PHE HIS ASP PRO ILE HIS GLU LEU ARG GLY          
SEQRES  12 B  213  LYS ILE GLN ASP LEU ARG GLU ILE ARG GLN ILE LYS VAL          
SEQRES  13 B  213  LEU LYS GLY LEU LYS TYR LEU ASN GLU SER HIS LEU GLN          
SEQRES  14 B  213  LEU ASP ASN LEU SER LEU LEU GLU ILE ASN GLU LEU ARG          
SEQRES  15 B  213  PRO PHE ILE THR GLU ILE MET ASP LYS LEU ARG GLU ILE          
SEQRES  16 B  213  HIS THR ALA SER LEU THR ALA GLY THR GLU ASN ASP GLU          
SEQRES  17 B  213  GLU GLU PHE ASN ILE                                          
SEQRES   1 C  194  MET GLY TYR TYR ASP ILE ASP ASP VAL LEU ALA ASP GLY          
SEQRES   2 C  194  THR GLU PHE PRO CYS LYS PHE GLN TYR ASP ILE PRO GLY          
SEQRES   3 C  194  LEU GLY TYR LEU GLU ASN ASN PRO GLY ARG PRO ILE THR          
SEQRES   4 C  194  LYS ASN THR LYS LEU SER LEU PRO LEU TRP LEU ALA ARG          
SEQRES   5 C  194  ILE LEU ALA ILE VAL GLY GLY ASP GLU ALA LEU VAL ASP          
SEQRES   6 C  194  GLU GLU PRO VAL PRO PHE VAL GLU LEU LEU PRO PRO ASP          
SEQRES   7 C  194  MET PHE SER THR LYS VAL MET ASN ALA ILE LYS THR ASP          
SEQRES   8 C  194  PRO VAL ALA LEU ASP LEU HIS SER ILE ASN SER HIS PHE          
SEQRES   9 C  194  PHE SER LEU ALA ILE LYS TRP ILE MET LEU PHE SER GLU          
SEQRES  10 C  194  LYS GLU LEU ALA ASN VAL VAL SER GLU LEU LEU LEU GLN          
SEQRES  11 C  194  ARG ALA GLN GLU LEU ASN HIS HIS ALA SER SER LEU SER          
SEQRES  12 C  194  ILE ASP LEU ASN ALA ASP SER THR GLY LYS ASN SER ALA          
SEQRES  13 C  194  ASN THR ASN ILE ALA THR SER THR PHE LEU LEU LYS LEU          
SEQRES  14 C  194  GLU GLU MET GLU LYS GLU ILE TYR LYS LYS SER HIS GLU          
SEQRES  15 C  194  SER TYR LYS ASP THR LYS ARG TRP MET PHE LYS LYS              
SEQRES   1 D  294  MET ASP ILE ASN ILE ASP ASP ILE LEU ALA GLU LEU ASP          
SEQRES   2 D  294  LYS GLU THR THR ALA VAL ASP SER THR LYS ILE THR GLN          
SEQRES   3 D  294  GLY SER SER SER THR THR HIS ARG ASP ALA ASN THR ILE          
SEQRES   4 D  294  VAL GLY SER SER LEU ASP LEU ASN ASP LYS THR GLN ILE          
SEQRES   5 D  294  TYR VAL SER PRO GLN GLN ASP PHE SER ASP LEU MET LYS          
SEQRES   6 D  294  SER TRP LYS ASN GLU ARG CYS SER PRO GLU LEU LEU PRO          
SEQRES   7 D  294  TYR PRO HIS GLN LEU MET LYS ARG LEU LEU ASN ARG ILE          
SEQRES   8 D  294  SER MET GLN SER GLN LEU ILE GLU ASN ILE SER MET GLY          
SEQRES   9 D  294  PHE LEU ASP MET GLN ASN ALA SER ASN ALA ASN PRO PRO          
SEQRES  10 D  294  MET PRO ASN GLU SER LYS LEU PRO LEU LEU CYS MET GLU          
SEQRES  11 D  294  THR GLU LEU GLU ARG LEU LYS PHE VAL ILE ARG SER TYR          
SEQRES  12 D  294  ILE ARG CYS ARG LEU SER LYS ILE ASP LYS PHE SER LEU          
SEQRES  13 D  294  TYR LEU ARG GLN LEU ASN GLU ASP GLU ASN SER LEU ILE          
SEQRES  14 D  294  SER LEU THR ASP LEU LEU SER LYS ASP GLU ILE LYS TYR          
SEQRES  15 D  294  HIS ASP THR HIS SER LEU ILE TRP LEU LYS LEU VAL ASN          
SEQRES  16 D  294  ASP SER ILE LEU LYS TYR MET PRO GLU GLU LEU GLN ALA          
SEQRES  17 D  294  ILE ASN ASP THR GLU GLY SER VAL ASN MET ILE ASP GLU          
SEQRES  18 D  294  PRO ASP TRP ASN LYS PHE VAL PHE ILE HIS VAL ASN GLY          
SEQRES  19 D  294  PRO PRO ASP GLY LYS TRP ASN GLU ASP PRO LEU LEU GLN          
SEQRES  20 D  294  GLU ASN GLU PHE GLY LYS PRO CYS TYR THR VAL THR ILE          
SEQRES  21 D  294  PRO ASP LEU LYS GLU GLU VAL GLU LEU THR ILE GLY SER          
SEQRES  22 D  294  ILE TYR VAL MET ARG TYR GLU VAL ILE ARG ASP LEU LEU          
SEQRES  23 D  294  ARG ASP ASP LYS VAL ALA LEU ILE                              
SEQRES   1 E  650  MET TYR TYR GLY ILE SER GLN PHE SER GLU ALA TYR ASN          
SEQRES   2 E  650  LYS ILE LEU ARG ASN SER SER SER HIS SER SER CYS GLN          
SEQRES   3 E  650  LEU VAL ILE PHE VAL SER CYS LEU ASN ILE ASP ALA LEU          
SEQRES   4 E  650  CYS ALA THR LYS MET LEU SER LEU LEU PHE LYS LYS GLN          
SEQRES   5 E  650  LEU VAL GLN SER GLN ILE VAL PRO ILE PHE GLY TYR SER          
SEQRES   6 E  650  GLU LEU ARG ARG HIS TYR SER GLN LEU ASP ASP ASN ILE          
SEQRES   7 E  650  ASN SER LEU LEU LEU VAL GLY PHE GLY GLY VAL ILE ASP          
SEQRES   8 E  650  LEU GLU ALA PHE LEU GLU ILE ASP PRO GLN GLU TYR VAL          
SEQRES   9 E  650  ILE ASP THR ASP GLU LYS SER GLY GLU GLN SER PHE ARG          
SEQRES  10 E  650  ARG ASP ILE TYR VAL LEU ASP ALA HIS ARG PRO TRP ASN          
SEQRES  11 E  650  LEU ASP ASN ILE PHE GLY SER GLN ILE ILE GLN CYS PHE          
SEQRES  12 E  650  ASP ASP GLY THR VAL ASP ASP THR LEU GLY GLU GLN LYS          
SEQRES  13 E  650  GLU ALA TYR TYR LYS LEU LEU GLU LEU ASP GLU GLU SER          
SEQRES  14 E  650  GLY ASP ASP GLU LEU SER GLY ASP GLU ASN ASP ASN ASN          
SEQRES  15 E  650  GLY GLY ASP ASP GLU ALA THR ASP ALA ASP GLU VAL THR          
SEQRES  16 E  650  ASP GLU ASP GLU GLU ASP GLU ASP GLU THR ILE SER ASN          
SEQRES  17 E  650  LYS ARG GLY ASN SER SER ILE GLY PRO ASN ASP LEU SER          
SEQRES  18 E  650  LYS ARG LYS GLN ARG LYS LYS GLN ILE HIS GLU TYR GLU          
SEQRES  19 E  650  GLY VAL LEU GLU GLU TYR TYR SER GLN GLY THR THR VAL          
SEQRES  20 E  650  VAL ASN SER ILE SER ALA GLN ILE TYR SER LEU LEU SER          
SEQRES  21 E  650  ALA ILE GLY GLU THR ASN LEU SER ASN LEU TRP LEU ASN          
SEQRES  22 E  650  ILE LEU GLY THR THR SER LEU ASP ILE ALA TYR ALA GLN          
SEQRES  23 E  650  VAL TYR ASN ARG LEU TYR PRO LEU LEU GLN ASP GLU VAL          
SEQRES  24 E  650  LYS ARG LEU THR PRO SER SER ARG ASN SER VAL LYS THR          
SEQRES  25 E  650  PRO ASP THR LEU THR LEU ASN ILE GLN PRO ASP TYR TYR          
SEQRES  26 E  650  LEU PHE LEU LEU ARG HIS SER SER LEU TYR ASP SER PHE          
SEQRES  27 E  650  TYR TYR SER ASN TYR VAL ASN ALA LYS LEU SER LEU TRP          
SEQRES  28 E  650  ASN GLU ASN GLY LYS LYS ARG LEU HIS LYS MET PHE ALA          
SEQRES  29 E  650  ARG MET GLY ILE PRO LEU SER THR ALA GLN GLU THR TRP          
SEQRES  30 E  650  LEU TYR MET ASP HIS SER ILE LYS ARG GLU LEU GLY ILE          
SEQRES  31 E  650  ILE PHE ASP LYS ASN LEU ASP ARG TYR GLY LEU GLN ASP          
SEQRES  32 E  650  ILE ILE ARG ASP GLY PHE VAL ARG THR LEU GLY TYR ARG          
SEQRES  33 E  650  GLY SER ILE SER ALA SER GLU PHE VAL GLU ALA LEU THR          
SEQRES  34 E  650  ALA LEU LEU GLU VAL GLY ASN SER THR ASP LYS ASP SER          
SEQRES  35 E  650  VAL LYS ILE ASN ASN ASP ASN ASN ASP ASP THR ASP GLY          
SEQRES  36 E  650  GLU GLU GLU GLU ASP ASN SER ALA GLN LYS LEU THR ASN          
SEQRES  37 E  650  LEU ARG LYS ARG TRP VAL SER ASN PHE TRP LEU SER TRP          
SEQRES  38 E  650  ASP ALA LEU ASP ASP ARG LYS VAL GLU LEU LEU ASN ARG          
SEQRES  39 E  650  GLY ILE GLN LEU ALA GLN ASP LEU GLN ARG ALA ILE PHE          
SEQRES  40 E  650  ASN THR GLY VAL ALA ILE LEU GLU LYS LYS LEU ILE LYS          
SEQRES  41 E  650  HIS LEU ARG ILE TYR ARG LEU CYS VAL LEU GLN ASP GLY          
SEQRES  42 E  650  PRO ASP LEU ASP LEU TYR ARG ASN PRO LEU THR LEU LEU          
SEQRES  43 E  650  ARG LEU GLY ASN TRP LEU ILE GLU CYS CYS ALA GLU SER          
SEQRES  44 E  650  GLU ASP LYS GLN LEU LEU PRO MET VAL LEU ALA SER ILE          
SEQRES  45 E  650  ASP GLU ASN THR ASP THR TYR LEU VAL ALA GLY LEU THR          
SEQRES  46 E  650  PRO ARG TYR PRO ARG GLY LEU ASP THR ILE HIS THR LYS          
SEQRES  47 E  650  LYS PRO ILE LEU ASN ASN PHE SER MET ALA PHE GLN GLN          
SEQRES  48 E  650  ILE THR ALA GLU THR ASP ALA LYS VAL ARG ILE ASP ASN          
SEQRES  49 E  650  PHE GLU SER SER ILE ILE GLU ILE ARG ARG GLU ASP LEU          
SEQRES  50 E  650  SER PRO PHE LEU GLU LYS LEU THR LEU SER GLY LEU LEU          
SEQRES   1 F   26   DA  DT  DC  DG  DA  DT  DC  DG  DA  DT  DC  DG  DA          
SEQRES   2 F   26   DT  DT  DT  DT  DT  DT  DT  DT  DT  DT  DT  DT  DT          
SEQRES   1 G   14   DA  DT  DC  DG  DA  DT  DC  DG  DA  DT  DC  DG  DA          
SEQRES   2 G   14   DT                                                          
SEQRES   1 2  868  MET SER ASP ASN ARG ARG ARG ARG ARG GLU GLU ASP ASP          
SEQRES   2 2  868  SER ASP SER GLU ASN GLU LEU PRO PRO SER SER PRO GLN          
SEQRES   3 2  868  GLN HIS PHE ARG GLY GLY MET ASN PRO VAL SER SER PRO          
SEQRES   4 2  868  ILE GLY SER PRO ASP MET ILE ASN PRO GLU GLY ASP ASP          
SEQRES   5 2  868  ASN GLU VAL ASP ASP VAL PRO ASP ILE ASP GLU VAL GLU          
SEQRES   6 2  868  GLU GLN MET ASN GLU VAL ASP LEU MET ASP ASP ASN MET          
SEQRES   7 2  868  TYR GLU ASP TYR ALA ALA ASP HIS ASN ARG ASP ARG TYR          
SEQRES   8 2  868  ASP PRO ASP GLN VAL ASP ASP ARG GLU GLN GLN GLU LEU          
SEQRES   9 2  868  SER LEU SER GLU ARG ARG ARG ILE ASP ALA GLN LEU ASN          
SEQRES  10 2  868  GLU ARG ASP ARG LEU LEU ARG ASN VAL ALA TYR ILE ASP          
SEQRES  11 2  868  ASP GLU ASP GLU GLU GLN GLU GLY ALA ALA GLN LEU ASP          
SEQRES  12 2  868  GLU MET GLY LEU PRO VAL GLN ARG ARG ARG ARG ARG ARG          
SEQRES  13 2  868  GLN TYR GLU ASP LEU GLU ASN SER ASP ASP ASP LEU LEU          
SEQRES  14 2  868  SER ASP MET ASP ILE ASP PRO LEU ARG GLU GLU LEU THR          
SEQRES  15 2  868  LEU GLU SER LEU SER ASN VAL LYS ALA ASN SER TYR SER          
SEQRES  16 2  868  GLU TRP ILE THR GLN PRO ASN VAL SER ARG THR ILE ALA          
SEQRES  17 2  868  ARG GLU LEU LYS SER PHE LEU LEU GLU TYR THR ASP GLU          
SEQRES  18 2  868  THR GLY ARG SER VAL TYR GLY ALA ARG ILE ARG THR LEU          
SEQRES  19 2  868  GLY GLU MET ASN SER GLU SER LEU GLU VAL ASN TYR ARG          
SEQRES  20 2  868  HIS LEU ALA GLU SER LYS ALA ILE LEU ALA LEU PHE LEU          
SEQRES  21 2  868  ALA LYS CYS PRO GLU GLU MET LEU LYS ILE PHE ASP LEU          
SEQRES  22 2  868  VAL ALA MET GLU ALA THR GLU LEU HIS TYR PRO ASP TYR          
SEQRES  23 2  868  ALA ARG ILE HIS SER GLU ILE HIS VAL ARG ILE SER ASP          
SEQRES  24 2  868  PHE PRO THR ILE TYR SER LEU ARG GLU LEU ARG GLU SER          
SEQRES  25 2  868  ASN LEU SER SER LEU VAL ARG VAL THR GLY VAL VAL THR          
SEQRES  26 2  868  ARG ARG THR GLY VAL PHE PRO GLN LEU LYS TYR VAL LYS          
SEQRES  27 2  868  PHE ASN CYS LEU LYS CYS GLY SER ILE LEU GLY PRO PHE          
SEQRES  28 2  868  PHE GLN ASP SER ASN GLU GLU ILE ARG ILE SER PHE CYS          
SEQRES  29 2  868  THR ASN CYS LYS SER LYS GLY PRO PHE ARG VAL ASN GLY          
SEQRES  30 2  868  GLU LYS THR VAL TYR ARG ASN TYR GLN ARG VAL THR LEU          
SEQRES  31 2  868  GLN GLU ALA PRO GLY THR VAL PRO PRO GLY ARG LEU PRO          
SEQRES  32 2  868  ARG HIS ARG GLU VAL ILE LEU LEU ALA ASP LEU VAL ASP          
SEQRES  33 2  868  VAL SER LYS PRO GLY GLU GLU VAL GLU VAL THR GLY ILE          
SEQRES  34 2  868  TYR LYS ASN ASN TYR ASP GLY ASN LEU ASN ALA LYS ASN          
SEQRES  35 2  868  GLY PHE PRO VAL PHE ALA THR ILE ILE GLU ALA ASN SER          
SEQRES  36 2  868  ILE LYS ARG ARG GLU GLY ASN THR ALA ASN GLU GLY GLU          
SEQRES  37 2  868  GLU GLY LEU ASP VAL PHE SER TRP THR GLU GLU GLU GLU          
SEQRES  38 2  868  ARG GLU PHE ARG LYS ILE SER ARG ASP ARG GLY ILE ILE          
SEQRES  39 2  868  ASP LYS ILE ILE SER SER MET ALA PRO SER ILE TYR GLY          
SEQRES  40 2  868  HIS ARG ASP ILE LYS THR ALA VAL ALA CYS SER LEU PHE          
SEQRES  41 2  868  GLY GLY VAL PRO LYS ASN VAL ASN GLY LYS HIS SER ILE          
SEQRES  42 2  868  ARG GLY ASP ILE ASN VAL LEU LEU LEU GLY ASP PRO GLY          
SEQRES  43 2  868  THR ALA LYS SER GLN ILE LEU LYS TYR VAL GLU LYS THR          
SEQRES  44 2  868  ALA HIS ARG ALA VAL PHE ALA THR GLY GLN GLY ALA SER          
SEQRES  45 2  868  ALA VAL GLY LEU THR ALA SER VAL ARG LYS ASP PRO ILE          
SEQRES  46 2  868  THR LYS GLU TRP THR LEU GLU GLY GLY ALA LEU VAL LEU          
SEQRES  47 2  868  ALA ASP LYS GLY VAL CYS LEU ILE ASP GLU PHE ASP LYS          
SEQRES  48 2  868  MET ASN ASP GLN ASP ARG THR SER ILE HIS GLU ALA MET          
SEQRES  49 2  868  GLU GLN GLN SER ILE SER ILE SER LYS ALA GLY ILE VAL          
SEQRES  50 2  868  THR THR LEU GLN ALA ARG CYS SER ILE ILE ALA ALA ALA          
SEQRES  51 2  868  ASN PRO ASN GLY GLY ARG TYR ASN SER THR LEU PRO LEU          
SEQRES  52 2  868  ALA GLN ASN VAL SER LEU THR GLU PRO ILE LEU SER ARG          
SEQRES  53 2  868  PHE ASP ILE LEU CYS VAL VAL ARG ASP LEU VAL ASP GLU          
SEQRES  54 2  868  GLU ALA ASP GLU ARG LEU ALA THR PHE VAL VAL ASP SER          
SEQRES  55 2  868  HIS VAL ARG SER HIS PRO GLU ASN ASP GLU ASP ARG GLU          
SEQRES  56 2  868  GLY GLU GLU LEU LYS ASN ASN GLY GLU SER ALA ILE GLU          
SEQRES  57 2  868  GLN GLY GLU ASP GLU ILE ASN GLU GLN LEU ASN ALA ARG          
SEQRES  58 2  868  GLN ARG ARG LEU GLN ARG GLN ARG LYS LYS GLU GLU GLU          
SEQRES  59 2  868  ILE SER PRO ILE PRO GLN GLU LEU LEU MET LYS TYR ILE          
SEQRES  60 2  868  HIS TYR ALA ARG THR LYS ILE TYR PRO LYS LEU HIS GLN          
SEQRES  61 2  868  MET ASP MET ASP LYS VAL SER ARG VAL TYR ALA ASP LEU          
SEQRES  62 2  868  ARG ARG GLU SER ILE SER THR GLY SER PHE PRO ILE THR          
SEQRES  63 2  868  VAL ARG HIS LEU GLU SER ILE LEU ARG ILE ALA GLU SER          
SEQRES  64 2  868  PHE ALA LYS MET ARG LEU SER GLU PHE VAL SER SER TYR          
SEQRES  65 2  868  ASP LEU ASP ARG ALA ILE LYS VAL VAL VAL ASP SER PHE          
SEQRES  66 2  868  VAL ASP ALA GLN LYS VAL SER VAL ARG ARG GLN LEU ARG          
SEQRES  67 2  868  ARG SER PHE ALA ILE TYR THR LEU GLY HIS                      
SEQRES   1 3  971  MET GLU GLY SER THR GLY PHE ASP GLY ASP ALA THR THR          
SEQRES   2 3  971  PHE PHE ALA PRO ASP ALA VAL PHE GLY ASP ARG VAL ARG          
SEQRES   3 3  971  ARG PHE GLN GLU PHE LEU ASP THR PHE THR SER TYR ARG          
SEQRES   4 3  971  ASP SER VAL ARG SER ILE GLN VAL TYR ASN SER ASN ASN          
SEQRES   5 3  971  ALA ALA ASN TYR ASN ASP ASP GLN ASP ASP ALA ASP GLU          
SEQRES   6 3  971  ARG ASP LEU LEU GLY ASP ASP ASP GLY ASP ASP LEU GLU          
SEQRES   7 3  971  LYS GLU LYS LYS ALA ALA SER SER THR SER LEU ASN ILE          
SEQRES   8 3  971  LEU PRO HIS ARG ILE ILE ILE SER LEU ASP ASP LEU ARG          
SEQRES   9 3  971  GLU PHE ASP ARG SER PHE TRP SER GLY ILE LEU VAL GLU          
SEQRES  10 3  971  PRO ALA TYR PHE ILE PRO PRO ALA GLU LYS ALA LEU THR          
SEQRES  11 3  971  ASP LEU ALA ASP SER MET ASP ASP VAL PRO HIS PRO ASN          
SEQRES  12 3  971  ALA SER ALA VAL SER SER ARG HIS PRO TRP LYS LEU SER          
SEQRES  13 3  971  PHE LYS GLY SER PHE GLY ALA HIS ALA LEU SER PRO ARG          
SEQRES  14 3  971  THR LEU THR ALA GLN HIS LEU ASN LYS LEU VAL SER VAL          
SEQRES  15 3  971  GLU GLY ILE VAL THR LYS THR SER LEU VAL ARG PRO LYS          
SEQRES  16 3  971  LEU ILE ARG SER VAL HIS TYR ALA ALA LYS THR GLY ARG          
SEQRES  17 3  971  PHE HIS TYR ARG ASP TYR THR ASP ALA THR THR THR LEU          
SEQRES  18 3  971  THR THR ARG ILE PRO THR PRO ALA ILE TYR PRO THR GLU          
SEQRES  19 3  971  ASP THR GLU GLY ASN LYS LEU THR THR GLU TYR GLY TYR          
SEQRES  20 3  971  SER THR PHE ILE ASP HIS GLN ARG ILE THR VAL GLN GLU          
SEQRES  21 3  971  MET PRO GLU MET ALA PRO ALA GLY GLN LEU PRO ARG SER          
SEQRES  22 3  971  ILE ASP VAL ILE LEU ASP ASP ASP LEU VAL ASP LYS THR          
SEQRES  23 3  971  LYS PRO GLY ASP ARG VAL ASN VAL VAL GLY VAL PHE LYS          
SEQRES  24 3  971  SER LEU GLY ALA GLY GLY MET ASN GLN SER ASN SER ASN          
SEQRES  25 3  971  THR LEU ILE GLY PHE LYS THR LEU ILE LEU GLY ASN THR          
SEQRES  26 3  971  VAL TYR PRO LEU HIS ALA ARG SER THR GLY VAL ALA ALA          
SEQRES  27 3  971  ARG GLN MET LEU THR ASP PHE ASP ILE ARG ASN ILE ASN          
SEQRES  28 3  971  LYS LEU SER LYS LYS LYS ASP ILE PHE ASP ILE LEU SER          
SEQRES  29 3  971  GLN SER LEU ALA PRO SER ILE TYR GLY HIS ASP HIS ILE          
SEQRES  30 3  971  LYS LYS ALA ILE LEU LEU MET LEU MET GLY GLY VAL GLU          
SEQRES  31 3  971  LYS ASN LEU GLU ASN GLY SER HIS LEU ARG GLY ASP ILE          
SEQRES  32 3  971  ASN ILE LEU MET VAL GLY ASP PRO SER THR ALA LYS SER          
SEQRES  33 3  971  GLN LEU LEU ARG PHE VAL LEU ASN THR ALA SER LEU ALA          
SEQRES  34 3  971  ILE ALA THR THR GLY ARG GLY SER SER GLY VAL GLY LEU          
SEQRES  35 3  971  THR ALA ALA VAL THR THR ASP ARG GLU THR GLY GLU ARG          
SEQRES  36 3  971  ARG LEU GLU ALA GLY ALA MET VAL LEU ALA ASP ARG GLY          
SEQRES  37 3  971  VAL VAL CYS ILE ASP GLU PHE ASP LYS MET THR ASP VAL          
SEQRES  38 3  971  ASP ARG VAL ALA ILE HIS GLU VAL MET GLU GLN GLN THR          
SEQRES  39 3  971  VAL THR ILE ALA LYS ALA GLY ILE HIS THR THR LEU ASN          
SEQRES  40 3  971  ALA ARG CYS SER VAL ILE ALA ALA ALA ASN PRO VAL PHE          
SEQRES  41 3  971  GLY GLN TYR ASP VAL ASN ARG ASP PRO HIS GLN ASN ILE          
SEQRES  42 3  971  ALA LEU PRO ASP SER LEU LEU SER ARG PHE ASP LEU LEU          
SEQRES  43 3  971  PHE VAL VAL THR ASP ASP ILE ASN GLU ILE ARG ASP ARG          
SEQRES  44 3  971  SER ILE SER GLU HIS VAL LEU ARG THR HIS ARG TYR LEU          
SEQRES  45 3  971  PRO PRO GLY TYR LEU GLU GLY GLU PRO VAL ARG GLU ARG          
SEQRES  46 3  971  LEU ASN LEU SER LEU ALA VAL GLY GLU ASP ALA ASP ILE          
SEQRES  47 3  971  ASN PRO GLU GLU HIS SER ASN SER GLY ALA GLY VAL GLU          
SEQRES  48 3  971  ASN GLU GLY GLU ASP ASP GLU ASP HIS VAL PHE GLU LYS          
SEQRES  49 3  971  PHE ASN PRO LEU LEU GLN ALA GLY ALA LYS LEU ALA LYS          
SEQRES  50 3  971  ASN LYS GLY ASN TYR ASN GLY THR GLU ILE PRO LYS LEU          
SEQRES  51 3  971  VAL THR ILE PRO PHE LEU ARG LYS TYR VAL GLN TYR ALA          
SEQRES  52 3  971  LYS GLU ARG VAL ILE PRO GLN LEU THR GLN GLU ALA ILE          
SEQRES  53 3  971  ASN VAL ILE VAL LYS ASN TYR THR ASP LEU ARG ASN ASP          
SEQRES  54 3  971  ASP ASN THR LYS LYS SER PRO ILE THR ALA ARG THR LEU          
SEQRES  55 3  971  GLU THR LEU ILE ARG LEU ALA THR ALA HIS ALA LYS VAL          
SEQRES  56 3  971  ARG LEU SER LYS THR VAL ASN LYS VAL ASP ALA LYS VAL          
SEQRES  57 3  971  ALA ALA ASN LEU LEU ARG PHE ALA LEU LEU GLY GLU ASP          
SEQRES  58 3  971  ILE GLY ASN ASP ILE ASP GLU GLU GLU SER GLU TYR GLU          
SEQRES  59 3  971  GLU ALA LEU SER LYS ARG SER PRO GLN LYS SER PRO LYS          
SEQRES  60 3  971  LYS ARG GLN ARG VAL ARG GLN PRO ALA SER ASN SER GLY          
SEQRES  61 3  971  SER PRO ILE LYS SER THR PRO ARG ARG SER THR ALA SER          
SEQRES  62 3  971  SER VAL ASN ALA THR PRO SER SER ALA ARG ARG ILE LEU          
SEQRES  63 3  971  ARG PHE GLN ASP ASP GLU GLN ASN ALA GLY GLU ASP ASP          
SEQRES  64 3  971  ASN ASP ILE MET SER PRO LEU PRO ALA ASP GLU GLU ALA          
SEQRES  65 3  971  GLU LEU GLN ARG ARG LEU GLN LEU GLY LEU ARG VAL SER          
SEQRES  66 3  971  PRO ARG ARG ARG GLU HIS LEU HIS ALA PRO GLU GLU GLY          
SEQRES  67 3  971  SER SER GLY PRO LEU THR GLU VAL GLY THR PRO ARG LEU          
SEQRES  68 3  971  PRO ASN VAL SER SER ALA GLY GLN ASP ASP GLU GLN GLN          
SEQRES  69 3  971  GLN SER VAL ILE SER PHE ASP ASN VAL GLU PRO GLY THR          
SEQRES  70 3  971  ILE SER THR GLY ARG LEU SER LEU ILE SER GLY ILE ILE          
SEQRES  71 3  971  ALA ARG LEU MET GLN THR GLU ILE PHE GLU GLU GLU SER          
SEQRES  72 3  971  TYR PRO VAL ALA SER LEU PHE GLU ARG ILE ASN GLU GLU          
SEQRES  73 3  971  LEU PRO GLU GLU GLU LYS PHE SER ALA GLN GLU TYR LEU          
SEQRES  74 3  971  ALA GLY LEU LYS ILE MET SER ASP ARG ASN ASN LEU MET          
SEQRES  75 3  971  VAL ALA ASP ASP LYS VAL TRP ARG VAL                          
SEQRES   1 4  933  MET SER GLN GLN SER SER SER PRO THR LYS GLU ASP ASN          
SEQRES   2 4  933  ASN SER SER SER PRO VAL VAL PRO ASN PRO ASP SER VAL          
SEQRES   3 4  933  PRO PRO GLN LEU SER SER PRO ALA LEU PHE TYR SER SER          
SEQRES   4 4  933  SER SER SER GLN GLY ASP ILE TYR GLY ARG ASN ASN SER          
SEQRES   5 4  933  GLN ASN LEU SER GLN GLY GLU GLY ASN ILE ARG ALA ALA          
SEQRES   6 4  933  ILE GLY SER SER PRO LEU ASN PHE PRO SER SER SER GLN          
SEQRES   7 4  933  ARG GLN ASN SER ASP VAL PHE GLN SER GLN GLY ARG GLN          
SEQRES   8 4  933  GLY ARG ILE ARG SER SER ALA SER ALA SER GLY ARG SER          
SEQRES   9 4  933  ARG TYR HIS SER ASP LEU ARG SER ASP ARG ALA LEU PRO          
SEQRES  10 4  933  THR SER SER SER SER LEU GLY ARG ASN GLY GLN ASN ARG          
SEQRES  11 4  933  VAL HIS MET ARG ARG ASN ASP ILE HIS THR SER ASP LEU          
SEQRES  12 4  933  SER SER PRO ARG ARG ILE VAL ASP PHE ASP THR ARG SER          
SEQRES  13 4  933  GLY VAL ASN THR LEU ASP THR SER SER SER SER ALA PRO          
SEQRES  14 4  933  PRO SER GLU ALA SER GLU PRO LEU ARG ILE ILE TRP GLY          
SEQRES  15 4  933  THR ASN VAL SER ILE GLN GLU CYS THR THR ASN PHE ARG          
SEQRES  16 4  933  ASN PHE LEU MET SER PHE LYS TYR LYS PHE ARG LYS ILE          
SEQRES  17 4  933  LEU ASP GLU ARG GLU GLU PHE ILE ASN ASN THR THR ASP          
SEQRES  18 4  933  GLU GLU LEU TYR TYR ILE LYS GLN LEU ASN GLU MET ARG          
SEQRES  19 4  933  GLU LEU GLY THR SER ASN LEU ASN LEU ASP ALA ARG ASN          
SEQRES  20 4  933  LEU LEU ALA TYR LYS GLN THR GLU ASP LEU TYR HIS GLN          
SEQRES  21 4  933  LEU LEU ASN TYR PRO GLN GLU VAL ILE SER ILE MET ASP          
SEQRES  22 4  933  GLN THR ILE LYS ASP CYS MET VAL SER LEU ILE VAL ASP          
SEQRES  23 4  933  ASN ASN LEU ASP TYR ASP LEU ASP GLU ILE GLU THR LYS          
SEQRES  24 4  933  PHE TYR LYS VAL ARG PRO TYR ASN VAL GLY SER CYS LYS          
SEQRES  25 4  933  GLY MET ARG GLU LEU ASN PRO ASN ASP ILE ASP LYS LEU          
SEQRES  26 4  933  ILE ASN LEU LYS GLY LEU VAL LEU ARG SER THR PRO VAL          
SEQRES  27 4  933  ILE PRO ASP MET LYS VAL ALA PHE PHE LYS CYS ASN VAL          
SEQRES  28 4  933  CYS ASP HIS THR MET ALA VAL GLU ILE ASP ARG GLY VAL          
SEQRES  29 4  933  ILE GLN GLU PRO ALA ARG CYS GLU ARG ILE ASP CYS ASN          
SEQRES  30 4  933  GLU PRO ASN SER MET SER LEU ILE HIS ASN ARG CYS SER          
SEQRES  31 4  933  PHE ALA ASP LYS GLN VAL ILE LYS LEU GLN GLU THR PRO          
SEQRES  32 4  933  ASP PHE VAL PRO ASP GLY GLN THR PRO HIS SER ILE SER          
SEQRES  33 4  933  LEU CYS VAL TYR ASP GLU LEU VAL ASP SER CYS ARG ALA          
SEQRES  34 4  933  GLY ASP ARG ILE GLU VAL THR GLY THR PHE ARG SER ILE          
SEQRES  35 4  933  PRO ILE ARG ALA ASN SER ARG GLN ARG VAL LEU LYS SER          
SEQRES  36 4  933  LEU TYR LYS THR TYR VAL ASP VAL VAL HIS VAL LYS VAL          
SEQRES  37 4  933  SER SER ASP LYS ARG LEU ASP VAL ASP THR SER THR ILE          
SEQRES  38 4  933  GLU GLN GLU LEU MET GLN ASN LYS VAL ASP HIS ASN GLU          
SEQRES  39 4  933  VAL GLU GLU VAL ARG GLN ILE THR ASP GLN ASP LEU ALA          
SEQRES  40 4  933  LYS ILE ARG GLU VAL ALA ALA ARG GLU ASP LEU TYR SER          
SEQRES  41 4  933  LEU LEU ALA ARG SER ILE ALA PRO SER ILE TYR GLU LEU          
SEQRES  42 4  933  GLU ASP VAL LYS LYS GLY ILE LEU LEU GLN LEU PHE GLY          
SEQRES  43 4  933  GLY THR ASN LYS THR PHE THR LYS GLY GLY ARG TYR ARG          
SEQRES  44 4  933  GLY ASP ILE ASN ILE LEU LEU CYS GLY ASP PRO SER THR          
SEQRES  45 4  933  SER LYS SER GLN ILE LEU GLN TYR VAL HIS LYS ILE THR          
SEQRES  46 4  933  PRO ARG GLY VAL TYR THR SER GLY LYS GLY SER SER ALA          
SEQRES  47 4  933  VAL GLY LEU THR ALA TYR ILE THR ARG ASP VAL ASP THR          
SEQRES  48 4  933  LYS GLN LEU VAL LEU GLU SER GLY ALA LEU VAL LEU SER          
SEQRES  49 4  933  ASP GLY GLY VAL CYS CYS ILE ASP GLU PHE ASP LYS MET          
SEQRES  50 4  933  SER ASP SER THR ARG SER VAL LEU HIS GLU VAL MET GLU          
SEQRES  51 4  933  GLN GLN THR ILE SER ILE ALA LYS ALA GLY ILE ILE THR          
SEQRES  52 4  933  THR LEU ASN ALA ARG SER SER ILE LEU ALA SER ALA ASN          
SEQRES  53 4  933  PRO ILE GLY SER ARG TYR ASN PRO ASN LEU PRO VAL THR          
SEQRES  54 4  933  GLU ASN ILE ASP LEU PRO PRO PRO LEU LEU SER ARG PHE          
SEQRES  55 4  933  ASP LEU VAL TYR LEU VAL LEU ASP LYS VAL ASP GLU LYS          
SEQRES  56 4  933  ASN ASP ARG GLU LEU ALA LYS HIS LEU THR ASN LEU TYR          
SEQRES  57 4  933  LEU GLU ASP LYS PRO GLU HIS ILE SER GLN ASP ASP VAL          
SEQRES  58 4  933  LEU PRO VAL GLU PHE LEU THR MET TYR ILE SER TYR ALA          
SEQRES  59 4  933  LYS GLU HIS ILE HIS PRO ILE ILE THR GLU ALA ALA LYS          
SEQRES  60 4  933  THR GLU LEU VAL ARG ALA TYR VAL GLY MET ARG LYS MET          
SEQRES  61 4  933  GLY ASP ASP SER ARG SER ASP GLU LYS ARG ILE THR ALA          
SEQRES  62 4  933  THR THR ARG GLN LEU GLU SER MET ILE ARG LEU ALA GLU          
SEQRES  63 4  933  ALA HIS ALA LYS MET LYS LEU LYS ASN VAL VAL GLU LEU          
SEQRES  64 4  933  GLU ASP VAL GLN GLU ALA VAL ARG LEU ILE ARG SER ALA          
SEQRES  65 4  933  ILE LYS ASP TYR ALA THR ASP PRO LYS THR GLY LYS ILE          
SEQRES  66 4  933  ASP MET ASN LEU VAL GLN THR GLY LYS SER VAL ILE GLN          
SEQRES  67 4  933  ARG LYS LEU GLN GLU ASP LEU SER ARG GLU ILE MET ASN          
SEQRES  68 4  933  VAL LEU LYS ASP GLN ALA SER ASP SER MET SER PHE ASN          
SEQRES  69 4  933  GLU LEU ILE LYS GLN ILE ASN GLU HIS SER GLN ASP ARG          
SEQRES  70 4  933  VAL GLU SER SER ASP ILE GLN GLU ALA LEU SER ARG LEU          
SEQRES  71 4  933  GLN GLN GLU ASP LYS VAL ILE VAL LEU GLY GLU GLY VAL          
SEQRES  72 4  933  ARG ARG SER VAL ARG LEU ASN ASN ARG VAL                      
SEQRES   1 5  775  MET SER PHE ASP ARG PRO GLU ILE TYR SER ALA PRO VAL          
SEQRES   2 5  775  LEU GLN GLY GLU SER PRO ASN ASP ASP ASP ASN THR GLU          
SEQRES   3 5  775  ILE ILE LYS SER PHE LYS ASN PHE ILE LEU GLU PHE ARG          
SEQRES   4 5  775  LEU ASP SER GLN PHE ILE TYR ARG ASP GLN LEU ARG ASN          
SEQRES   5 5  775  ASN ILE LEU VAL LYS ASN TYR SER LEU THR VAL ASN MET          
SEQRES   6 5  775  GLU HIS LEU ILE GLY TYR ASN GLU ASP ILE TYR LYS LYS          
SEQRES   7 5  775  LEU SER ASP GLU PRO SER ASP ILE ILE PRO LEU PHE GLU          
SEQRES   8 5  775  THR ALA ILE THR GLN VAL ALA LYS ARG ILE SER ILE LEU          
SEQRES   9 5  775  SER ARG ALA GLN SER ALA ASN ASN ASN ASP LYS ASP PRO          
SEQRES  10 5  775  GLU ASN THR SER MET ASP THR ASP SER LEU LEU LEU ASN          
SEQRES  11 5  775  SER LEU PRO THR PHE GLN LEU ILE LEU ASN SER ASN ALA          
SEQRES  12 5  775  ASN GLN ILE PRO LEU ARG ASP LEU ASP SER GLU HIS VAL          
SEQRES  13 5  775  SER LYS ILE VAL ARG LEU SER GLY ILE ILE ILE SER THR          
SEQRES  14 5  775  SER VAL LEU SER SER ARG ALA THR TYR LEU SER ILE MET          
SEQRES  15 5  775  CYS ARG ASN CYS ARG HIS THR THR SER ILE THR ILE ASN          
SEQRES  16 5  775  ASN PHE ASN SER ILE THR GLY ASN THR VAL SER LEU PRO          
SEQRES  17 5  775  ARG SER CYS LEU SER THR ILE GLU SER GLU SER SER MET          
SEQRES  18 5  775  ALA ASN GLU SER ASN ILE GLY ASP GLU SER THR LYS LYS          
SEQRES  19 5  775  ASN CYS GLY PRO ASP PRO TYR ILE ILE ILE HIS GLU SER          
SEQRES  20 5  775  SER LYS PHE ILE ASP GLN GLN PHE LEU LYS LEU GLN GLU          
SEQRES  21 5  775  ILE PRO GLU LEU VAL PRO VAL GLY GLU MET PRO ARG ASN          
SEQRES  22 5  775  LEU THR MET THR CYS ASP ARG TYR LEU THR ASN LYS VAL          
SEQRES  23 5  775  ILE PRO GLY THR ARG VAL THR ILE VAL GLY ILE TYR SER          
SEQRES  24 5  775  ILE TYR ASN SER LYS ASN GLY ALA GLY SER GLY ARG SER          
SEQRES  25 5  775  GLY GLY GLY ASN GLY GLY SER GLY VAL ALA ILE ARG THR          
SEQRES  26 5  775  PRO TYR ILE LYS ILE LEU GLY ILE GLN SER ASP VAL GLU          
SEQRES  27 5  775  THR SER SER ILE TRP ASN SER VAL THR MET PHE THR GLU          
SEQRES  28 5  775  GLU GLU GLU GLU GLU PHE LEU GLN LEU SER ARG ASN PRO          
SEQRES  29 5  775  LYS LEU TYR GLU ILE LEU THR ASN SER ILE ALA PRO SER          
SEQRES  30 5  775  ILE PHE GLY ASN GLU ASP ILE LYS LYS ALA ILE VAL CYS          
SEQRES  31 5  775  LEU LEU MET GLY GLY SER LYS LYS ILE LEU PRO ASP GLY          
SEQRES  32 5  775  MET ARG LEU ARG GLY ASP ILE ASN VAL LEU LEU LEU GLY          
SEQRES  33 5  775  ASP PRO GLY THR ALA LYS SER GLN LEU LEU LYS PHE VAL          
SEQRES  34 5  775  GLU LYS VAL SER PRO ILE ALA VAL TYR THR SER GLY LYS          
SEQRES  35 5  775  GLY SER SER ALA ALA GLY LEU THR ALA SER VAL GLN ARG          
SEQRES  36 5  775  ASP PRO MET THR ARG GLU PHE TYR LEU GLU GLY GLY ALA          
SEQRES  37 5  775  MET VAL LEU ALA ASP GLY GLY VAL VAL CYS ILE ASP GLU          
SEQRES  38 5  775  PHE ASP LYS MET ARG ASP GLU ASP ARG VAL ALA ILE HIS          
SEQRES  39 5  775  GLU ALA MET GLU GLN GLN THR ILE SER ILE ALA LYS ALA          
SEQRES  40 5  775  GLY ILE THR THR VAL LEU ASN SER ARG THR SER VAL LEU          
SEQRES  41 5  775  ALA ALA ALA ASN PRO ILE TYR GLY ARG TYR ASP ASP LEU          
SEQRES  42 5  775  LYS SER PRO GLY ASP ASN ILE ASP PHE GLN THR THR ILE          
SEQRES  43 5  775  LEU SER ARG PHE ASP MET ILE PHE ILE VAL LYS ASP ASP          
SEQRES  44 5  775  HIS ASN GLU GLU ARG ASP ILE SER ILE ALA ASN HIS VAL          
SEQRES  45 5  775  ILE ASN ILE HIS THR GLY ASN ALA ASN ALA MET GLN ASN          
SEQRES  46 5  775  GLN GLN GLU GLU ASN GLY SER GLU ILE SER ILE GLU LYS          
SEQRES  47 5  775  MET LYS ARG TYR ILE THR TYR CYS ARG LEU LYS CYS ALA          
SEQRES  48 5  775  PRO ARG LEU SER PRO GLN ALA ALA GLU LYS LEU SER SER          
SEQRES  49 5  775  ASN PHE VAL THR ILE ARG LYS GLN LEU LEU ILE ASN GLU          
SEQRES  50 5  775  LEU GLU SER THR GLU ARG SER SER ILE PRO ILE THR ILE          
SEQRES  51 5  775  ARG GLN LEU GLU ALA ILE ILE ARG ILE THR GLU SER LEU          
SEQRES  52 5  775  ALA LYS LEU GLU LEU SER PRO ILE ALA GLN GLU ARG HIS          
SEQRES  53 5  775  VAL ASP GLU ALA ILE ARG LEU PHE GLN ALA SER THR MET          
SEQRES  54 5  775  ASP ALA ALA SER GLN ASP PRO ILE GLY GLY LEU ASN GLN          
SEQRES  55 5  775  ALA SER GLY THR SER LEU SER GLU ILE ARG ARG PHE GLU          
SEQRES  56 5  775  GLN GLU LEU LYS ARG ARG LEU PRO ILE GLY TRP SER THR          
SEQRES  57 5  775  SER TYR GLN THR LEU ARG ARG GLU PHE VAL ASP THR HIS          
SEQRES  58 5  775  ARG PHE SER GLN LEU ALA LEU ASP LYS ALA LEU TYR ALA          
SEQRES  59 5  775  LEU GLU LYS HIS GLU THR ILE GLN LEU ARG HIS GLN GLY          
SEQRES  60 5  775  GLN ASN ILE TYR ARG SER GLY VAL                              
SEQRES   1 6 1017  MET SER SER PRO PHE PRO ALA ASP THR PRO SER SER ASN          
SEQRES   2 6 1017  ARG PRO SER ASN SER SER PRO PRO PRO SER SER ILE GLY          
SEQRES   3 6 1017  ALA GLY PHE GLY SER SER SER GLY LEU ASP SER GLN ILE          
SEQRES   4 6 1017  GLY SER ARG LEU HIS PHE PRO SER SER SER GLN PRO HIS          
SEQRES   5 6 1017  VAL SER ASN SER GLN THR GLY PRO PHE VAL ASN ASP SER          
SEQRES   6 6 1017  THR GLN PHE SER SER GLN ARG LEU GLN THR ASP GLY SER          
SEQRES   7 6 1017  ALA THR ASN ASP MET GLU GLY ASN GLU PRO ALA ARG SER          
SEQRES   8 6 1017  PHE LYS SER ARG ALA LEU ASN HIS VAL LYS LYS VAL ASP          
SEQRES   9 6 1017  ASP VAL THR GLY GLU LYS VAL ARG GLU ALA PHE GLU GLN          
SEQRES  10 6 1017  PHE LEU GLU ASP PHE SER VAL GLN SER THR ASP THR GLY          
SEQRES  11 6 1017  GLU VAL GLU LYS VAL TYR ARG ALA GLN ILE GLU PHE MET          
SEQRES  12 6 1017  LYS ILE TYR ASP LEU ASN THR ILE TYR ILE ASP TYR GLN          
SEQRES  13 6 1017  HIS LEU SER MET ARG GLU ASN GLY ALA LEU ALA MET ALA          
SEQRES  14 6 1017  ILE SER GLU GLN TYR TYR ARG PHE LEU PRO PHE LEU GLN          
SEQRES  15 6 1017  LYS GLY LEU ARG ARG VAL VAL ARG LYS TYR ALA PRO GLU          
SEQRES  16 6 1017  LEU LEU ASN THR SER ASP SER LEU LYS ARG SER GLU GLY          
SEQRES  17 6 1017  ASP GLU GLY GLN ALA ASP GLU ASP GLU GLN GLN ASP ASP          
SEQRES  18 6 1017  ASP MET ASN GLY SER SER LEU PRO ARG ASP SER GLY SER          
SEQRES  19 6 1017  SER ALA ALA PRO GLY ASN GLY THR SER ALA MET ALA THR          
SEQRES  20 6 1017  ARG SER ILE THR THR SER THR SER PRO GLU GLN THR GLU          
SEQRES  21 6 1017  ARG VAL PHE GLN ILE SER PHE PHE ASN LEU PRO THR VAL          
SEQRES  22 6 1017  HIS ARG ILE ARG ASP ILE ARG SER GLU LYS ILE GLY SER          
SEQRES  23 6 1017  LEU LEU SER ILE SER GLY THR VAL THR ARG THR SER GLU          
SEQRES  24 6 1017  VAL ARG PRO GLU LEU TYR LYS ALA SER PHE THR CYS ASP          
SEQRES  25 6 1017  MET CYS ARG ALA ILE VAL ASP ASN VAL GLU GLN SER PHE          
SEQRES  26 6 1017  LYS TYR THR GLU PRO THR PHE CYS PRO ASN PRO SER CYS          
SEQRES  27 6 1017  GLU ASN ARG ALA PHE TRP THR LEU ASN VAL THR ARG SER          
SEQRES  28 6 1017  ARG PHE LEU ASP TRP GLN LYS VAL ARG ILE GLN GLU ASN          
SEQRES  29 6 1017  ALA ASN GLU ILE PRO THR GLY SER MET PRO ARG THR LEU          
SEQRES  30 6 1017  ASP VAL ILE LEU ARG GLY ASP SER VAL GLU ARG ALA LYS          
SEQRES  31 6 1017  PRO GLY ASP ARG CYS LYS PHE THR GLY VAL GLU ILE VAL          
SEQRES  32 6 1017  VAL PRO ASP VAL THR GLN LEU GLY LEU PRO GLY VAL LYS          
SEQRES  33 6 1017  PRO SER SER THR LEU ASP THR ARG GLY ILE SER LYS THR          
SEQRES  34 6 1017  THR GLU GLY LEU ASN SER GLY VAL THR GLY LEU ARG SER          
SEQRES  35 6 1017  LEU GLY VAL ARG ASP LEU THR TYR LYS ILE SER PHE LEU          
SEQRES  36 6 1017  ALA CYS HIS VAL ILE SER ILE GLY SER ASN ILE GLY ALA          
SEQRES  37 6 1017  SER SER PRO ASP ALA ASN SER ASN ASN ARG GLU THR GLU          
SEQRES  38 6 1017  LEU GLN MET ALA ALA ASN LEU GLN ALA ASN ASN VAL TYR          
SEQRES  39 6 1017  GLN ASP ASN GLU ARG ASP GLN GLU VAL PHE LEU ASN SER          
SEQRES  40 6 1017  LEU SER SER ASP GLU ILE ASN GLU LEU LYS GLU MET VAL          
SEQRES  41 6 1017  LYS ASP GLU HIS ILE TYR ASP LYS LEU VAL ARG SER ILE          
SEQRES  42 6 1017  ALA PRO ALA VAL PHE GLY HIS GLU ALA VAL LYS LYS GLY          
SEQRES  43 6 1017  ILE LEU LEU GLN MET LEU GLY GLY VAL HIS LYS SER THR          
SEQRES  44 6 1017  VAL GLU GLY ILE LYS LEU ARG GLY ASP ILE ASN ILE CYS          
SEQRES  45 6 1017  VAL VAL GLY ASP PRO SER THR SER LYS SER GLN PHE LEU          
SEQRES  46 6 1017  LYS TYR VAL VAL GLY PHE ALA PRO ARG SER VAL TYR THR          
SEQRES  47 6 1017  SER GLY LYS ALA SER SER ALA ALA GLY LEU THR ALA ALA          
SEQRES  48 6 1017  VAL VAL ARG ASP GLU GLU GLY GLY ASP TYR THR ILE GLU          
SEQRES  49 6 1017  ALA GLY ALA LEU MET LEU ALA ASP ASN GLY ILE CYS CYS          
SEQRES  50 6 1017  ILE ASP GLU PHE ASP LYS MET ASP ILE SER ASP GLN VAL          
SEQRES  51 6 1017  ALA ILE HIS GLU ALA MET GLU GLN GLN THR ILE SER ILE          
SEQRES  52 6 1017  ALA LYS ALA GLY ILE HIS ALA THR LEU ASN ALA ARG THR          
SEQRES  53 6 1017  SER ILE LEU ALA ALA ALA ASN PRO VAL GLY GLY ARG TYR          
SEQRES  54 6 1017  ASN ARG LYS LEU SER LEU ARG GLY ASN LEU ASN MET THR          
SEQRES  55 6 1017  ALA PRO ILE MET SER ARG PHE ASP LEU PHE PHE VAL ILE          
SEQRES  56 6 1017  LEU ASP ASP CYS ASN GLU LYS ILE ASP THR GLU LEU ALA          
SEQRES  57 6 1017  SER HIS ILE VAL ASP LEU HIS MET LYS ARG ASP GLU ALA          
SEQRES  58 6 1017  ILE GLU PRO PRO PHE SER ALA GLU GLN LEU ARG ARG TYR          
SEQRES  59 6 1017  ILE LYS TYR ALA ARG THR PHE LYS PRO ILE LEU THR LYS          
SEQRES  60 6 1017  GLU ALA ARG SER TYR LEU VAL GLU LYS TYR LYS GLU LEU          
SEQRES  61 6 1017  ARG LYS ASP ASP ALA GLN GLY PHE SER ARG SER SER TYR          
SEQRES  62 6 1017  ARG ILE THR VAL ARG GLN LEU GLU SER MET ILE ARG LEU          
SEQRES  63 6 1017  SER GLU ALA ILE ALA ARG ALA ASN CYS VAL ASP GLU ILE          
SEQRES  64 6 1017  THR PRO SER PHE ILE ALA GLU ALA TYR ASP LEU LEU ARG          
SEQRES  65 6 1017  GLN SER ILE ILE ARG VAL ASP VAL ASP ASP VAL GLU MET          
SEQRES  66 6 1017  ASP GLU GLU PHE ASP ASN ILE GLU SER GLN SER HIS ALA          
SEQRES  67 6 1017  ALA SER GLY ASN ASN ASP ASP ASN ASP ASP GLY THR GLY          
SEQRES  68 6 1017  SER GLY VAL ILE THR SER GLU PRO PRO ALA ASP ILE GLU          
SEQRES  69 6 1017  GLU GLY GLN SER GLU ALA THR ALA ARG PRO GLY THR SER          
SEQRES  70 6 1017  GLU LYS LYS LYS THR THR VAL THR TYR ASP LYS TYR VAL          
SEQRES  71 6 1017  SER MET MET ASN MET ILE VAL ARG LYS ILE ALA GLU VAL          
SEQRES  72 6 1017  ASP ARG GLU GLY ALA GLU GLU LEU THR ALA VAL ASP ILE          
SEQRES  73 6 1017  VAL ASP TRP TYR LEU LEU GLN LYS GLU ASN ASP LEU GLY          
SEQRES  74 6 1017  SER LEU ALA GLU TYR TRP GLU GLU ARG ARG LEU ALA PHE          
SEQRES  75 6 1017  LYS VAL ILE LYS ARG LEU VAL LYS ASP ARG ILE LEU MET          
SEQRES  76 6 1017  GLU ILE HIS GLY THR ARG HIS ASN LEU ARG ASP LEU GLU          
SEQRES  77 6 1017  ASN GLU GLU ASN GLU ASN ASN LYS THR VAL TYR VAL ILE          
SEQRES  78 6 1017  HIS PRO ASN CYS GLU VAL LEU ASP GLN LEU GLU PRO GLN          
SEQRES  79 6 1017  ASP SER SER                                                  
SEQRES   1 7  845  MET SER ALA ALA LEU PRO SER ILE GLN LEU PRO VAL ASP          
SEQRES   2 7  845  TYR ASN ASN LEU PHE ASN GLU ILE THR ASP PHE LEU VAL          
SEQRES   3 7  845  THR PHE LYS GLN ASP THR LEU SER SER ASP ALA THR ARG          
SEQRES   4 7  845  ASN GLU ASN GLU ASP GLU ASN LEU ASP ALA GLU ASN ILE          
SEQRES   5 7  845  GLU GLN HIS LEU LEU GLU LYS GLY PRO LYS TYR MET ALA          
SEQRES   6 7  845  MET LEU GLN LYS VAL ALA ASN ARG GLU LEU ASN SER VAL          
SEQRES   7 7  845  ILE ILE ASP LEU ASP ASP ILE LEU GLN TYR GLN ASN GLU          
SEQRES   8 7  845  LYS PHE LEU GLN GLY THR GLN ALA ASP ASP LEU VAL SER          
SEQRES   9 7  845  ALA ILE GLN GLN ASN ALA ASN HIS PHE THR GLU LEU PHE          
SEQRES  10 7  845  CYS ARG ALA ILE ASP ASN ASN MET PRO LEU PRO THR LYS          
SEQRES  11 7  845  GLU ILE ASP TYR LYS ASP ASP VAL LEU ASP VAL ILE LEU          
SEQRES  12 7  845  ASN GLN ARG ARG LEU ARG ASN GLU ARG MET LEU SER ASP          
SEQRES  13 7  845  ARG THR ASN GLU ILE ARG SER GLU ASN LEU MET ASP THR          
SEQRES  14 7  845  THR MET ASP PRO PRO SER SER MET ASN ASP ALA LEU ARG          
SEQRES  15 7  845  GLU VAL VAL GLU ASP GLU THR GLU LEU PHE PRO PRO ASN          
SEQRES  16 7  845  LEU THR ARG ARG TYR PHE LEU TYR PHE LYS PRO LEU SER          
SEQRES  17 7  845  GLN ASN CYS ALA ARG ARG TYR ARG LYS LYS ALA ILE SER          
SEQRES  18 7  845  SER LYS PRO LEU SER VAL ARG GLN ILE LYS GLY ASP PHE          
SEQRES  19 7  845  LEU GLY GLN LEU ILE THR VAL ARG GLY ILE ILE THR ARG          
SEQRES  20 7  845  VAL SER ASP VAL LYS PRO ALA VAL GLU VAL ILE ALA TYR          
SEQRES  21 7  845  THR CYS ASP GLN CYS GLY TYR GLU VAL PHE GLN GLU VAL          
SEQRES  22 7  845  ASN SER ARG THR PHE THR PRO LEU SER GLU CYS THR SER          
SEQRES  23 7  845  GLU GLU CYS SER GLN ASN GLN THR LYS GLY GLN LEU PHE          
SEQRES  24 7  845  MET SER THR ARG ALA SER LYS PHE SER ALA PHE GLN GLU          
SEQRES  25 7  845  CYS LYS ILE GLN GLU LEU SER GLN GLN VAL PRO VAL GLY          
SEQRES  26 7  845  HIS ILE PRO ARG SER LEU ASN ILE HIS VAL ASN GLY THR          
SEQRES  27 7  845  LEU VAL ARG SER LEU SER PRO GLY ASP ILE VAL ASP VAL          
SEQRES  28 7  845  THR GLY ILE PHE LEU PRO ALA PRO TYR THR GLY PHE LYS          
SEQRES  29 7  845  ALA LEU LYS ALA GLY LEU LEU THR GLU THR TYR LEU GLU          
SEQRES  30 7  845  ALA GLN PHE VAL ARG GLN HIS LYS LYS LYS PHE ALA SER          
SEQRES  31 7  845  PHE SER LEU THR SER ASP VAL GLU GLU ARG VAL MET GLU          
SEQRES  32 7  845  LEU ILE THR SER GLY ASP VAL TYR ASN ARG LEU ALA LYS          
SEQRES  33 7  845  SER ILE ALA PRO GLU ILE TYR GLY ASN LEU ASP VAL LYS          
SEQRES  34 7  845  LYS ALA LEU LEU LEU LEU LEU VAL GLY GLY VAL ASP LYS          
SEQRES  35 7  845  ARG VAL GLY ASP GLY MET LYS ILE ARG GLY ASP ILE ASN          
SEQRES  36 7  845  VAL CYS LEU MET GLY ASP PRO GLY VAL ALA LYS SER GLN          
SEQRES  37 7  845  LEU LEU LYS ALA ILE CYS LYS ILE SER PRO ARG GLY VAL          
SEQRES  38 7  845  TYR THR THR GLY LYS GLY SER SER GLY VAL GLY LEU THR          
SEQRES  39 7  845  ALA ALA VAL MET LYS ASP PRO VAL THR ASP GLU MET ILE          
SEQRES  40 7  845  LEU GLU GLY GLY ALA LEU VAL LEU ALA ASP ASN GLY ILE          
SEQRES  41 7  845  CYS CYS ILE ASP GLU PHE ASP LYS MET ASP GLU SER ASP          
SEQRES  42 7  845  ARG THR ALA ILE HIS GLU VAL MET GLU GLN GLN THR ILE          
SEQRES  43 7  845  SER ILE SER LYS ALA GLY ILE ASN THR THR LEU ASN ALA          
SEQRES  44 7  845  ARG THR SER ILE LEU ALA ALA ALA ASN PRO LEU TYR GLY          
SEQRES  45 7  845  ARG TYR ASN PRO ARG LEU SER PRO LEU ASP ASN ILE ASN          
SEQRES  46 7  845  LEU PRO ALA ALA LEU LEU SER ARG PHE ASP ILE LEU PHE          
SEQRES  47 7  845  LEU MET LEU ASP ILE PRO SER ARG ASP ASP ASP GLU LYS          
SEQRES  48 7  845  LEU ALA GLU HIS VAL THR TYR VAL HIS MET HIS ASN LYS          
SEQRES  49 7  845  GLN PRO ASP LEU ASP PHE THR PRO VAL GLU PRO SER LYS          
SEQRES  50 7  845  MET ARG GLU TYR ILE ALA TYR ALA LYS THR LYS ARG PRO          
SEQRES  51 7  845  VAL MET SER GLU ALA VAL ASN ASP TYR VAL VAL GLN ALA          
SEQRES  52 7  845  TYR ILE ARG LEU ARG GLN ASP SER LYS ARG GLU MET ASP          
SEQRES  53 7  845  SER LYS PHE SER PHE GLY GLN ALA THR PRO ARG THR LEU          
SEQRES  54 7  845  LEU GLY ILE ILE ARG LEU SER GLN ALA LEU ALA LYS LEU          
SEQRES  55 7  845  ARG LEU ALA ASP MET VAL ASP ILE ASP ASP VAL GLU GLU          
SEQRES  56 7  845  ALA LEU ARG LEU VAL ARG VAL SER LYS GLU SER LEU TYR          
SEQRES  57 7  845  GLN GLU THR ASN LYS SER LYS GLU ASP GLU SER PRO THR          
SEQRES  58 7  845  THR LYS ILE PHE THR ILE ILE LYS LYS MET LEU GLN GLU          
SEQRES  59 7  845  THR GLY LYS ASN THR LEU SER TYR GLU ASN ILE VAL LYS          
SEQRES  60 7  845  THR VAL ARG LEU ARG GLY PHE THR MET LEU GLN LEU SER          
SEQRES  61 7  845  ASN CYS ILE GLN GLU TYR SER TYR LEU ASN VAL TRP HIS          
SEQRES  62 7  845  LEU ILE ASN GLU GLY ASN THR LEU LYS PHE VAL ASP ASP          
SEQRES  63 7  845  GLY THR MET ASP THR ASP GLN GLU ASP SER LEU VAL SER          
SEQRES  64 7  845  THR PRO LYS LEU ALA PRO GLN THR THR ALA SER ALA ASN          
SEQRES  65 7  845  VAL SER ALA GLN ASP SER ASP ILE ASP LEU GLN ASP ALA          
HET    ATP  2 901      31                                                       
HET    ATP  31001      31                                                       
HET    ATP  5 801      31                                                       
HETNAM     ATP ADENOSINE-5'-TRIPHOSPHATE                                        
FORMUL  14  ATP    3(C10 H16 N5 O13 P3)                                         
HELIX    1 AA1 GLY A    3  ARG A   22  1                                  20    
HELIX    2 AA2 HIS A   33  GLN A   58  1                                  26    
HELIX    3 AA3 VAL A   67  ASN A  104  1                                  38    
HELIX    4 AA4 ASP A  119  LEU A  123  5                                   5    
HELIX    5 AA5 SER A  124  ASP A  145  1                                  22    
HELIX    6 AA6 GLN A  193  GLN A  202  1                                  10    
HELIX    7 AA7 SER B   12  GLU B   21  1                                  10    
HELIX    8 AA8 LEU B   73  GLN B   82  1                                  10    
HELIX    9 AA9 THR B   94  THR B  107  1                                  14    
HELIX   10 AB1 ASN B  118  PHE B  127  1                                  10    
HELIX   11 AB2 LYS B  129  PHE B  134  5                                   6    
HELIX   12 AB3 GLU B  140  LYS B  161  1                                  22    
HELIX   13 AB4 SER B  174  LEU B  200  1                                  27    
HELIX   14 AB5 ASP C    5  THR C   14  1                                  10    
HELIX   15 AB6 LEU C   48  ALA C   55  1                                   8    
HELIX   16 AB7 PRO C   77  PHE C   80  5                                   4    
HELIX   17 AB8 SER C   81  ASP C   91  1                                  11    
HELIX   18 AB9 ASP C   96  ASN C  101  1                                   6    
HELIX   19 AC1 PHE C  104  SER C  116  1                                  13    
HELIX   20 AC2 LYS C  118  HIS C  138  1                                  21    
HELIX   21 AC3 THR C  164  LEU C  169  5                                   6    
HELIX   22 AC4 GLU C  170  PHE C  192  1                                  23    
HELIX   23 AC5 SER D   55  SER D   73  1                                  19    
HELIX   24 AC6 PRO D   80  GLY D  104  1                                  25    
HELIX   25 AC7 PHE D  105  GLN D  109  5                                   5    
HELIX   26 AC8 LYS D  123  ASP D  164  1                                  42    
HELIX   27 AC9 SER D  176  ASP D  196  1                                  21    
HELIX   28 AD1 ILE D  282  ASP D  289  1                                   8    
HELIX   29 AD2 GLN E    7  ASN E   18  1                                  12    
HELIX   30 AD3 ASN E   35  LEU E   53  1                                  19    
HELIX   31 AD4 LEU E   67  SER E   72  1                                   6    
HELIX   32 AD5 ASP E   91  LEU E   96  1                                   6    
HELIX   33 AD6 ASN E  130  PHE E  135  1                                   6    
HELIX   34 AD7 ASP E  219  TYR E  240  1                                  22    
HELIX   35 AD8 SER E  250  ILE E  262  1                                  13    
HELIX   36 AD9 ASN E  266  SER E  279  1                                  14    
HELIX   37 AE1 VAL E  287  LEU E  302  1                                  16    
HELIX   38 AE2 SER E  333  TYR E  340  1                                   8    
HELIX   39 AE3 SER E  341  SER E  349  1                                   9    
HELIX   40 AE4 ASN E  352  GLY E  367  1                                  16    
HELIX   41 AE5 PRO E  369  GLU E  375  1                                   7    
HELIX   42 AE6 THR E  376  MET E  380  5                                   5    
HELIX   43 AE7 ASP E  381  GLU E  387  1                                   7    
HELIX   44 AE8 GLU E  387  ASN E  395  1                                   9    
HELIX   45 AE9 LEU E  396  GLY E  400  5                                   5    
HELIX   46 AF1 GLY E  414  ARG E  416  5                                   3    
HELIX   47 AF2 ALA E  421  VAL E  434  1                                  14    
HELIX   48 AF3 ALA E  463  ALA E  483  1                                  21    
HELIX   49 AF4 LYS E  488  GLU E  490  5                                   3    
HELIX   50 AF5 LEU E  491  LYS E  517  1                                  27    
HELIX   51 AF6 ASP E  537  ARG E  540  5                                   4    
HELIX   52 AF7 ASN E  541  ALA E  557  1                                  17    
HELIX   53 AF8 ASN E  604  ALA E  614  1                                  11    
HELIX   54 AF9 ARG E  633  LEU E  646  1                                  14    
HELIX   55 AG1 VAL 2  203  GLU 2  217  1                                  15    
HELIX   56 AG2 SER 2  225  MET 2  237  1                                  13    
HELIX   57 AG3 ASN 2  245  LYS 2  253  1                                   9    
HELIX   58 AG4 LYS 2  253  CYS 2  263  1                                  11    
HELIX   59 AG5 CYS 2  263  LEU 2  281  1                                  19    
HELIX   60 AG6 ASP 2  285  ILE 2  289  5                                   5    
HELIX   61 AG7 ALA 2  393  VAL 2  397  5                                   5    
HELIX   62 AG8 ASP 2  413  VAL 2  415  5                                   3    
HELIX   63 AG9 THR 2  477  ARG 2  489  1                                  13    
HELIX   64 AH1 GLY 2  492  SER 2  500  1                                   9    
HELIX   65 AH2 HIS 2  508  GLY 2  521  1                                  14    
HELIX   66 AH3 ALA 2  548  ALA 2  560  1                                  13    
HELIX   67 AH4 GLY 2  594  ALA 2  599  1                                   6    
HELIX   68 AH5 PHE 2  609  MET 2  612  5                                   4    
HELIX   69 AH6 ASN 2  613  GLN 2  627  1                                  15    
HELIX   70 AH7 PRO 2  662  VAL 2  667  1                                   6    
HELIX   71 AH8 THR 2  670  ARG 2  676  1                                   7    
HELIX   72 AH9 ASP 2  688  ARG 2  694  1                                   7    
HELIX   73 AI1 LEU 2  695  HIS 2  703  1                                   9    
HELIX   74 AI2 PRO 2  759  LYS 2  773  1                                  15    
HELIX   75 AI3 HIS 2  779  SER 2  799  1                                  21    
HELIX   76 AI4 THR 2  806  LEU 2  825  1                                  20    
HELIX   77 AI5 SER 2  830  ALA 2  848  1                                  19    
HELIX   78 AI6 SER 2  852  PHE 2  861  1                                  10    
HELIX   79 AI7 ALA 2  862  TYR 2  864  5                                   3    
HELIX   80 AI8 ASP 3   18  PHE 3   28  1                                  11    
HELIX   81 AI9 GLN 3   29  THR 3   34  1                                   6    
HELIX   82 AJ1 PHE 3   35  SER 3   37  5                                   3    
HELIX   83 AJ2 TYR 3   38  TYR 3   56  1                                  19    
HELIX   84 AJ3 SER 3   99  GLU 3  105  5                                   7    
HELIX   85 AJ4 ASP 3  107  GLU 3  117  1                                  11    
HELIX   86 AJ5 GLU 3  117  ASP 3  137  1                                  21    
HELIX   87 AJ6 ASP 3  281  VAL 3  283  5                                   3    
HELIX   88 AJ7 ASP 3  344  LYS 3  356  1                                  13    
HELIX   89 AJ8 ASP 3  358  SER 3  366  1                                   9    
HELIX   90 AJ9 HIS 3  374  GLY 3  387  1                                  14    
HELIX   91 AK1 ALA 3  414  THR 3  425  1                                  12    
HELIX   92 AK2 GLY 3  460  ALA 3  465  1                                   6    
HELIX   93 AK3 THR 3  479  GLU 3  491  1                                  13    
HELIX   94 AK4 ASP 3  537  PHE 3  543  1                                   7    
HELIX   95 AK5 ASN 3  554  HIS 3  569  1                                  16    
HELIX   96 AK6 THR 3  652  ARG 3  666  1                                  15    
HELIX   97 AK7 THR 3  672  ASP 3  690  1                                  19    
HELIX   98 AK8 ASN 3  691  LYS 3  693  5                                   3    
HELIX   99 AK9 THR 3  698  ARG 3  716  1                                  19    
HELIX  100 AL1 ASN 3  722  LEU 3  738  1                                  17    
HELIX  101 AL2 GLU 4  189  SER 4  200  1                                  12    
HELIX  102 AL3 PHE 4  205  ASP 4  210  1                                   6    
HELIX  103 AL4 LEU 4  224  GLY 4  237  1                                  14    
HELIX  104 AL5 THR 4  254  TYR 4  264  1                                  11    
HELIX  105 AL6 TYR 4  264  VAL 4  285  1                                  22    
HELIX  106 AL7 ASP 4  294  LYS 4  299  1                                   6    
HELIX  107 AL8 ASN 4  318  ILE 4  322  5                                   5    
HELIX  108 AL9 TYR 4  420  VAL 4  424  5                                   5    
HELIX  109 AM1 THR 4  502  ARG 4  515  1                                  14    
HELIX  110 AM2 ASP 4  517  ALA 4  527  1                                  11    
HELIX  111 AM3 LEU 4  533  PHE 4  545  1                                  13    
HELIX  112 AM4 SER 4  573  THR 4  585  1                                  13    
HELIX  113 AM5 GLY 4  619  ASP 4  625  1                                   7    
HELIX  114 AM6 ARG 4  642  GLN 4  652  1                                  11    
HELIX  115 AM7 PRO 4  687  ASP 4  693  1                                   7    
HELIX  116 AM8 PRO 4  695  PHE 4  702  1                                   8    
HELIX  117 AM9 ASP 4  713  THR 4  725  1                                  13    
HELIX  118 AN1 GLU 4  745  HIS 4  757  1                                  13    
HELIX  119 AN2 GLU 4  764  ARG 4  778  1                                  15    
HELIX  120 AN3 THR 4  794  MET 4  811  1                                  18    
HELIX  121 AN4 LYS 4  812  LYS 4  814  5                                   3    
HELIX  122 AN5 ASP 4  821  LYS 4  834  1                                  14    
HELIX  123 AN6 ILE 4  857  GLN 4  876  1                                  20    
HELIX  124 AN7 SER 4  882  ILE 4  890  1                                   9    
HELIX  125 AN8 GLU 4  899  GLN 4  912  1                                  14    
HELIX  126 AN9 GLU 5   26  LEU 5   36  1                                  11    
HELIX  127 AO1 ILE 5   45  LYS 5   57  1                                  13    
HELIX  128 AO2 MET 5   65  ASN 5   72  1                                   8    
HELIX  129 AO3 ASN 5   72  GLU 5   82  1                                  11    
HELIX  130 AO4 GLU 5   82  ILE 5   87  1                                   6    
HELIX  131 AO5 ILE 5   87  ILE 5  103  1                                  17    
HELIX  132 AO6 ASP 5  152  VAL 5  156  5                                   5    
HELIX  133 AO7 ASP 5  279  THR 5  283  5                                   5    
HELIX  134 AO8 GLU 5  351  ASN 5  363  1                                  13    
HELIX  135 AO9 LYS 5  365  ILE 5  374  1                                  10    
HELIX  136 AP1 ASN 5  381  MET 5  393  1                                  13    
HELIX  137 AP2 ALA 5  421  SER 5  433  1                                  13    
HELIX  138 AP3 GLY 5  467  ALA 5  472  1                                   6    
HELIX  139 AP4 ARG 5  486  MET 5  497  1                                  12    
HELIX  140 AP5 ARG 5  529  LYS 5  534  1                                   6    
HELIX  141 AP6 THR 5  544  PHE 5  550  1                                   7    
HELIX  142 AP7 ASN 5  561  HIS 5  576  1                                  16    
HELIX  143 AP8 ASN 5  579  SER 5  592  1                                  14    
HELIX  144 AP9 ILE 5  596  CYS 5  610  1                                  15    
HELIX  145 AQ1 SER 5  615  GLU 5  637  1                                  23    
HELIX  146 AQ2 LEU 5  638  SER 5  640  5                                   3    
HELIX  147 AQ3 THR 5  649  LEU 5  668  1                                  20    
HELIX  148 AQ4 GLN 5  673  SER 5  693  1                                  21    
HELIX  149 AQ5 ASP 6  104  ASP 6  121  1                                  18    
HELIX  150 AQ6 VAL 6  135  ASP 6  147  1                                  13    
HELIX  151 AQ7 TYR 6  155  GLU 6  162  1                                   8    
HELIX  152 AQ8 GLY 6  164  GLU 6  172  1                                   9    
HELIX  153 AQ9 GLN 6  173  ALA 6  193  1                                  21    
HELIX  154 AR1 ARG 6  280  ILE 6  284  5                                   5    
HELIX  155 AR2 ARG 6  382  VAL 6  386  5                                   5    
HELIX  156 AR3 ASP 6  511  ASP 6  522  1                                  12    
HELIX  157 AR4 HIS 6  524  SER 6  532  1                                   9    
HELIX  158 AR5 GLU 6  541  LEU 6  552  1                                  12    
HELIX  159 AR6 LYS 6  581  GLY 6  590  1                                  10    
HELIX  160 AR7 PHE 6  641  MET 6  644  5                                   4    
HELIX  161 AR8 ILE 6  646  MET 6  656  1                                  11    
HELIX  162 AR9 SER 6  694  LEU 6  699  1                                   6    
HELIX  163 AS1 THR 6  702  PHE 6  709  1                                   8    
HELIX  164 AS2 ASN 6  720  MET 6  736  1                                  17    
HELIX  165 AS3 SER 6  747  THR 6  760  1                                  14    
HELIX  166 AS4 GLU 6  768  LYS 6  782  1                                  15    
HELIX  167 AS5 VAL 6  797  CYS 6  815  1                                  19    
HELIX  168 AS6 THR 6  820  ARG 6  837  1                                  18    
HELIX  169 AS7 TYR 7   14  LEU 7   25  1                                  12    
HELIX  170 AS8 PRO 7   61  ASN 7   72  1                                  12    
HELIX  171 AS9 LEU 7   82  LYS 7   92  1                                  11    
HELIX  172 AT1 LEU 7  102  ILE 7  106  5                                   5    
HELIX  173 AT2 ALA 7  120  MET 7  125  1                                   6    
HELIX  174 AT3 LEU 7  139  LEU 7  154  1                                  16    
HELIX  175 AT4 LYS 7  231  LEU 7  235  5                                   5    
HELIX  176 AT5 THR 7  338  VAL 7  340  5                                   3    
HELIX  177 AT6 GLU 7  398  THR 7  406  1                                   9    
HELIX  178 AT7 ASN 7  412  ILE 7  418  1                                   7    
HELIX  179 AT8 ASN 7  425  LEU 7  436  1                                  12    
HELIX  180 AT9 ALA 7  465  SER 7  477  1                                  13    
HELIX  181 AU1 ALA 7  512  ASP 7  517  1                                   6    
HELIX  182 AU2 MET 7  529  MET 7  541  1                                  13    
HELIX  183 AU3 PRO 7  587  ARG 7  593  1                                   7    
HELIX  184 AU4 SER 7  605  HIS 7  622  1                                  18    
HELIX  185 AU5 GLU 7  634  THR 7  647  1                                  14    
HELIX  186 AU6 SER 7  653  SER 7  671  1                                  19    
HELIX  187 AU7 THR 7  685  LEU 7  704  1                                  20    
HELIX  188 AU8 ASP 7  709  SER 7  723  1                                  15    
HELIX  189 AU9 GLU 7  725  GLN 7  729  5                                   5    
SHEET    1 AA1 2 PHE A 162  ILE A 163  0                                        
SHEET    2 AA1 2 VAL A 191  ARG A 192 -1  O  VAL A 191   N  ILE A 163           
SHEET    1 AA2 2 PRO B  24  ILE B  27  0                                        
SHEET    2 AA2 2 THR B  69  VAL B  72 -1  O  VAL B  71   N  ILE B  25           
SHEET    1 AA3 3 LEU B 168  ASP B 171  0                                        
SHEET    2 AA3 3 ILE D 274  ARG D 278 -1  O  ILE D 274   N  LEU B 170           
SHEET    3 AA3 3 PHE D 227  VAL D 228 -1  N  VAL D 228   O  MET D 277           
SHEET    1 AA4 2 GLU C  15  PRO C  17  0                                        
SHEET    2 AA4 2 SER C  45  PRO C  47 -1  O  LEU C  46   N  PHE C  16           
SHEET    1 AA5 2 VAL E  28  SER E  32  0                                        
SHEET    2 AA5 2 GLN E  57  ILE E  61  1  O  VAL E  59   N  VAL E  31           
SHEET    1 AA6 2 LEU E  81  LEU E  83  0                                        
SHEET    2 AA6 2 ILE E 120  VAL E 122  1  O  TYR E 121   N  LEU E  83           
SHEET    1 AA7 2 HIS E 126  ARG E 127  0                                        
SHEET    2 AA7 2 THR E 246  VAL E 247 -1  O  THR E 246   N  ARG E 127           
SHEET    1 AA8 3 ASN E 319  ILE E 320  0                                        
SHEET    2 AA8 3 PHE E 409  THR E 412 -1  O  VAL E 410   N  ASN E 319           
SHEET    3 AA8 3 SER E 418  SER E 420 -1  O  ILE E 419   N  ARG E 411           
SHEET    1 AA9 2 LEU E 580  ALA E 582  0                                        
SHEET    2 AA9 2 ILE E 629  GLU E 631 -1  O  ILE E 630   N  VAL E 581           
SHEET    1 AB1 5 PHE 2 331  GLN 2 333  0                                        
SHEET    2 AB1 5 ARG 2 383  GLN 2 391 -1  O  TYR 2 385   N  PHE 2 331           
SHEET    3 AB1 5 LEU 2 317  ARG 2 327 -1  N  VAL 2 323   O  GLN 2 391           
SHEET    4 AB1 5 GLU 2 423  LYS 2 431 -1  O  VAL 2 426   N  VAL 2 320           
SHEET    5 AB1 5 ILE 2 450  ILE 2 451 -1  O  ILE 2 450   N  LYS 2 431           
SHEET    1 AB2 5 GLU 2 407  LEU 2 411  0                                        
SHEET    2 AB2 5 ARG 2 383  GLN 2 391 -1  N  VAL 2 388   O  VAL 2 408           
SHEET    3 AB2 5 LEU 2 317  ARG 2 327 -1  N  VAL 2 323   O  GLN 2 391           
SHEET    4 AB2 5 GLU 2 423  LYS 2 431 -1  O  VAL 2 426   N  VAL 2 320           
SHEET    5 AB2 5 SER 2 455  ARG 2 458 -1  O  LYS 2 457   N  GLU 2 425           
SHEET    1 AB3 2 VAL 2 337  LYS 2 338  0                                        
SHEET    2 AB3 2 PRO 2 350  PHE 2 351 -1  O  PHE 2 351   N  VAL 2 337           
SHEET    1 AB4 5 ALA 2 563  PHE 2 565  0                                        
SHEET    2 AB4 5 VAL 2 603  ASP 2 607  1  O  VAL 2 603   N  VAL 2 564           
SHEET    3 AB4 5 ILE 2 646  ALA 2 650  1  O  ILE 2 647   N  CYS 2 604           
SHEET    4 AB4 5 VAL 2 539  LEU 2 542  1  N  VAL 2 539   O  ILE 2 646           
SHEET    5 AB4 5 ILE 2 679  CYS 2 681  1  O  CYS 2 681   N  LEU 2 542           
SHEET    1 AB5 5 SER 3 190  LEU 3 196  0                                        
SHEET    2 AB5 5 PHE 3 250  GLN 3 259 -1  O  HIS 3 253   N  ARG 3 193           
SHEET    3 AB5 5 LEU 3 179  VAL 3 186 -1  N  ILE 3 185   O  GLN 3 259           
SHEET    4 AB5 5 ARG 3 291  LYS 3 299 -1  O  VAL 3 294   N  VAL 3 182           
SHEET    5 AB5 5 TYR 3 327  PRO 3 328 -1  O  TYR 3 327   N  ASN 3 293           
SHEET    1 AB6 6 SER 3 190  LEU 3 196  0                                        
SHEET    2 AB6 6 PHE 3 250  GLN 3 259 -1  O  HIS 3 253   N  ARG 3 193           
SHEET    3 AB6 6 ILE 3 274  ASP 3 279 -1  O  LEU 3 278   N  GLN 3 254           
SHEET    4 AB6 6 LEU 3 320  LEU 3 322  1  O  ILE 3 321   N  ASP 3 275           
SHEET    5 AB6 6 ARG 3 291  LYS 3 299 -1  N  LYS 3 299   O  LEU 3 320           
SHEET    6 AB6 6 TYR 3 327  PRO 3 328 -1  O  TYR 3 327   N  ASN 3 293           
SHEET    1 AB7 3 GLY 3 207  ARG 3 212  0                                        
SHEET    2 AB7 3 SER 3 199  ALA 3 203 -1  N  HIS 3 201   O  HIS 3 210           
SHEET    3 AB7 3 LEU 3 241  GLU 3 244 -1  O  GLU 3 244   N  VAL 3 200           
SHEET    1 AB8 5 ALA 3 431  THR 3 433  0                                        
SHEET    2 AB8 5 CYS 3 471  ASP 3 473  1  O  ASP 3 473   N  THR 3 432           
SHEET    3 AB8 5 ILE 3 513  ALA 3 516  1  O  ALA 3 515   N  ILE 3 472           
SHEET    4 AB8 5 ILE 3 405  GLY 3 409  1  N  MET 3 407   O  ALA 3 514           
SHEET    5 AB8 5 LEU 3 545  VAL 3 549  1  O  VAL 3 549   N  VAL 3 408           
SHEET    1 AB9 2 VAL 3 495  ALA 3 498  0                                        
SHEET    2 AB9 2 HIS 3 503  LEU 3 506 -1  O  LEU 3 506   N  VAL 3 495           
SHEET    1 AC1 2 GLY 4 330  SER 4 335  0                                        
SHEET    2 AC1 2 ILE 4 397  GLU 4 401 -1  O  LYS 4 398   N  ARG 4 334           
SHEET    1 AC2 2 ILE 4 339  MET 4 342  0                                        
SHEET    2 AC2 2 PHE 4 391  LYS 4 394 -1  O  LYS 4 394   N  ILE 4 339           
SHEET    1 AC3 2 PHE 4 439  ILE 4 442  0                                        
SHEET    2 AC3 2 LYS 4 458  VAL 4 461 -1  O  TYR 4 460   N  ARG 4 440           
SHEET    1 AC4 5 VAL 4 589  THR 4 591  0                                        
SHEET    2 AC4 5 CYS 4 629  ILE 4 631  1  O  CYS 4 630   N  VAL 4 589           
SHEET    3 AC4 5 LEU 4 672  ALA 4 675  1  O  SER 4 674   N  ILE 4 631           
SHEET    4 AC4 5 ILE 4 564  CYS 4 567  1  N  LEU 4 566   O  ALA 4 673           
SHEET    5 AC4 5 LEU 4 704  LEU 4 707  1  O  TYR 4 706   N  CYS 4 567           
SHEET    1 AC5 2 THR 4 606  ARG 4 607  0                                        
SHEET    2 AC5 2 LEU 4 614  VAL 4 615 -1  O  VAL 4 615   N  THR 4 606           
SHEET    1 AC6 2 THR 4 653  ILE 4 656  0                                        
SHEET    2 AC6 2 THR 4 663  ASN 4 666 -1  O  THR 4 663   N  ILE 4 656           
SHEET    1 AC7 3 SER 4 880  MET 4 881  0                                        
SHEET    2 AC7 3 ARG 4 924  SER 4 926 -1  O  ARG 4 924   N  MET 4 881           
SHEET    3 AC7 3 VAL 4 916  ILE 4 917 -1  N  ILE 4 917   O  ARG 4 925           
SHEET    1 AC8 2 SER 5  60  ASN 5  64  0                                        
SHEET    2 AC8 2 GLN 5 136  ASN 5 140  1  O  ILE 5 138   N  LEU 5  61           
SHEET    1 AC9 6 ILE 5 159  THR 5 169  0                                        
SHEET    2 AC9 6 LEU 5 256  GLN 5 259 -1  O  LYS 5 257   N  SER 5 168           
SHEET    3 AC9 6 ASN 5 273  THR 5 277 -1  O  LEU 5 274   N  LEU 5 258           
SHEET    4 AC9 6 THR 5 325  LYS 5 329  1  O  ILE 5 328   N  THR 5 277           
SHEET    5 AC9 6 ARG 5 291  TYR 5 301 -1  N  ILE 5 297   O  LYS 5 329           
SHEET    6 AC9 6 ILE 5 159  THR 5 169 -1  N  LEU 5 162   O  ILE 5 294           
SHEET    1 AD1 3 THR 5 189  THR 5 193  0                                        
SHEET    2 AD1 3 SER 5 173  CYS 5 183 -1  N  LEU 5 179   O  ILE 5 192           
SHEET    3 AD1 3 TYR 5 241  GLN 5 253 -1  O  ILE 5 251   N  ARG 5 175           
SHEET    1 AD2 2 VAL 5 412  LEU 5 413  0                                        
SHEET    2 AD2 2 MET 5 552  ILE 5 553  1  O  MET 5 552   N  LEU 5 413           
SHEET    1 AD3 3 ALA 5 436  THR 5 439  0                                        
SHEET    2 AD3 3 VAL 5 476  ILE 5 479  1  O  CYS 5 478   N  VAL 5 437           
SHEET    3 AD3 3 SER 5 518  ALA 5 521  1  O  SER 5 518   N  VAL 5 477           
SHEET    1 AD4 2 SER 5 452  GLN 5 454  0                                        
SHEET    2 AD4 2 TYR 5 463  GLY 5 466 -1  O  TYR 5 463   N  GLN 5 454           
SHEET    1 AD5 2 THR 5 501  SER 5 503  0                                        
SHEET    2 AD5 2 VAL 5 512  ASN 5 514 -1  O  LEU 5 513   N  ILE 5 502           
SHEET    1 AD6 2 ARG 5 613  LEU 5 614  0                                        
SHEET    2 AD6 2 ILE 5 671  ALA 5 672  1  O  ALA 5 672   N  ARG 5 613           
SHEET    1 AD7 2 THR 6 150  ASP 6 154  0                                        
SHEET    2 AD7 2 GLN 6 264  PHE 6 268  1  O  SER 6 266   N  ILE 6 153           
SHEET    1 AD8 3 THR 6 293  THR 6 295  0                                        
SHEET    2 AD8 3 GLN 6 357  GLN 6 362 -1  O  GLN 6 362   N  THR 6 293           
SHEET    3 AD8 3 LEU 6 377  LEU 6 381 -1  O  VAL 6 379   N  VAL 6 359           
SHEET    1 AD9 2 ALA 6 307  THR 6 310  0                                        
SHEET    2 AD9 2 THR 6 345  SER 6 351 -1  O  ASN 6 347   N  SER 6 308           
SHEET    1 AE1 2 LYS 6 396  PHE 6 397  0                                        
SHEET    2 AE1 2 VAL 6 459  ILE 6 460 -1  O  ILE 6 460   N  LYS 6 396           
SHEET    1 AE2 2 VAL 6 404  PRO 6 405  0                                        
SHEET    2 AE2 2 TYR 6 450  LYS 6 451 -1  O  LYS 6 451   N  VAL 6 404           
SHEET    1 AE3 4 ASN 6 570  CYS 6 572  0                                        
SHEET    2 AE3 4 SER 6 677  ALA 6 681  1  O  ALA 6 680   N  ILE 6 571           
SHEET    3 AE3 4 ILE 6 635  ASP 6 639  1  N  CYS 6 636   O  SER 6 677           
SHEET    4 AE3 4 VAL 6 596  TYR 6 597  1  N  VAL 6 596   O  CYS 6 637           
SHEET    1 AE4 2 ILE 6 661  SER 6 662  0                                        
SHEET    2 AE4 2 THR 6 671  LEU 6 672 -1  O  LEU 6 672   N  ILE 6 661           
SHEET    1 AE5 2 VAL 7  78  ASP 7  81  0                                        
SHEET    2 AE5 2 LEU 7 202  LYS 7 205  1  O  TYR 7 203   N  VAL 7  78           
SHEET    1 AE6 4 LYS 7 252  VAL 7 255  0                                        
SHEET    2 AE6 4 PHE 7 307  GLN 7 316 -1  O  SER 7 308   N  ALA 7 254           
SHEET    3 AE6 4 ASN 7 332  ASN 7 336 -1  O  VAL 7 335   N  GLN 7 311           
SHEET    4 AE6 4 LEU 7 376  GLU 7 377  1  O  LEU 7 376   N  ASN 7 332           
SHEET    1 AE7 5 LYS 7 252  VAL 7 255  0                                        
SHEET    2 AE7 5 PHE 7 307  GLN 7 316 -1  O  SER 7 308   N  ALA 7 254           
SHEET    3 AE7 5 LEU 7 238  THR 7 246 -1  N  ILE 7 244   O  GLN 7 316           
SHEET    4 AE7 5 ILE 7 348  ILE 7 354 -1  O  GLY 7 353   N  ILE 7 239           
SHEET    5 AE7 5 PHE 7 380  GLN 7 383 -1  O  PHE 7 380   N  THR 7 352           
SHEET    1 AE8 2 VAL 7 257  TYR 7 260  0                                        
SHEET    2 AE8 2 VAL 7 269  GLU 7 272 -1  O  VAL 7 269   N  TYR 7 260           
SHEET    1 AE9 5 VAL 7 481  TYR 7 482  0                                        
SHEET    2 AE9 5 ILE 7 520  ILE 7 523  1  O  CYS 7 522   N  VAL 7 481           
SHEET    3 AE9 5 SER 7 562  ALA 7 567  1  O  LEU 7 564   N  CYS 7 521           
SHEET    4 AE9 5 ASN 7 455  MET 7 459  1  N  LEU 7 458   O  ALA 7 567           
SHEET    5 AE9 5 ILE 7 596  LEU 7 599  1  O  ILE 7 596   N  CYS 7 457           
SHEET    1 AF1 2 ALA 7 496  VAL 7 497  0                                        
SHEET    2 AF1 2 LEU 7 508  GLU 7 509 -1  O  GLU 7 509   N  ALA 7 496           
SHEET    1 AF2 2 ILE 7 546  SER 7 547  0                                        
SHEET    2 AF2 2 THR 7 556  LEU 7 557 -1  O  LEU 7 557   N  ILE 7 546           
SSBOND   1 CYS 5  183    CYS 5  236                          1555   1555  2.03  
SSBOND   2 CYS 5  183    CYS 5  186                          1555   1555  2.84  
SSBOND   3 CYS 5  183    CYS 5  211                          1555   1555  2.03  
SSBOND   4 CYS 5  186    CYS 5  236                          1555   1555  2.02  
SSBOND   5 CYS 5  186    CYS 5  211                          1555   1555  2.04  
SSBOND   6 CYS 5  211    CYS 5  236                          1555   1555  2.03  
SSBOND   7 CYS 7  265    CYS 7  289                          1555   1555  2.03  
SSBOND   8 CYS 7  474    CYS 7  522                          1555   1555  2.03  
CISPEP   1 ARG A   22    SER A   23          0       -20.14                     
CISPEP   2 SER A   23    ASN A   24          0       -11.85                     
CISPEP   3 ASN A  105    GLY A  106          0         1.91                     
CISPEP   4 GLY A  106    LEU A  107          0       -27.65                     
CISPEP   5 ASP A  108    LEU A  109          0        -8.97                     
CISPEP   6 MET A  110    SER A  111          0        -1.45                     
CISPEP   7 ASP A  145    LEU A  146          0         2.75                     
CISPEP   8 VAL A  147    ASP A  148          0        12.41                     
CISPEP   9 ILE A  149    ASP A  150          0         5.46                     
CISPEP  10 SER A  159    ASP A  160          0       -28.56                     
CISPEP  11 ALA A  171    GLY A  172          0        -1.26                     
CISPEP  12 GLY A  172    GLU A  173          0         3.76                     
CISPEP  13 HIS B    6    LEU B    7          0         1.61                     
CISPEP  14 LEU B    7    GLN B    8          0       -22.11                     
CISPEP  15 TRP B   50    GLN B   51          0         4.93                     
CISPEP  16 GLN B   51    LEU B   52          0        16.75                     
CISPEP  17 ALA B   59    LEU B   60          0         1.75                     
CISPEP  18 GLU B  165    SER B  166          0        -7.58                     
CISPEP  19 GLY C   35    ARG C   36          0        -5.99                     
CISPEP  20 ASN C  101    SER C  102          0         6.87                     
CISPEP  21 THR C  162    SER C  163          0       -11.34                     
CISPEP  22 ASN D  166    SER D  167          0        -0.40                     
CISPEP  23 LYS D  200    TYR D  201          0        25.90                     
CISPEP  24 THR D  212    GLU D  213          0         4.32                     
CISPEP  25 GLY D  214    SER D  215          0       -12.21                     
CISPEP  26 SER D  215    VAL D  216          0       -12.99                     
CISPEP  27 VAL D  216    ASN D  217          0         5.35                     
CISPEP  28 MET D  218    ILE D  219          0        15.30                     
CISPEP  29 ASP D  220    GLU D  221          0        11.40                     
CISPEP  30 GLY D  252    LYS D  253          0        -1.49                     
CISPEP  31 TYR D  256    THR D  257          0        -1.58                     
CISPEP  32 VAL D  267    GLU D  268          0         4.87                     
CISPEP  33 HIS E   22    SER E   23          0        -6.05                     
CISPEP  34 SER E   24    CYS E   25          0         6.67                     
CISPEP  35 CYS E   25    GLN E   26          0         1.12                     
CISPEP  36 SER E   32    CYS E   33          0       -14.31                     
CISPEP  37 GLU E   97    ILE E   98          0        26.87                     
CISPEP  38 ILE E   98    ASP E   99          0        15.60                     
CISPEP  39 ARG E  127    PRO E  128          0         2.63                     
CISPEP  40 ILE E  140    GLN E  141          0        -2.44                     
CISPEP  41 ASP E  145    GLY E  146          0        -8.05                     
CISPEP  42 ASP E  149    ASP E  150          0         0.82                     
CISPEP  43 ASP E  150    THR E  151          0         9.51                     
CISPEP  44 THR E  151    LEU E  152          0         3.95                     
CISPEP  45 LEU E  163    GLU E  164          0        -0.97                     
CISPEP  46 ALA E  285    GLN E  286          0       -19.58                     
CISPEP  47 ASN E  308    SER E  309          0        -1.94                     
CISPEP  48 VAL E  310    LYS E  311          0         2.89                     
CISPEP  49 LYS E  311    THR E  312          0        -0.62                     
CISPEP  50 THR E  315    LEU E  316          0        11.76                     
CISPEP  51 GLU E  558    SER E  559          0        -0.47                     
CISPEP  52 SER E  559    GLU E  560          0        12.35                     
CISPEP  53 ASP E  561    LYS E  562          0         1.78                     
CISPEP  54 LEU E  646    SER E  647          0         3.63                     
CISPEP  55 LEU 2  234    GLY 2  235          0       -26.23                     
CISPEP  56 PRO 2  301    THR 2  302          0        -3.82                     
CISPEP  57 SER 2  346    ILE 2  347          0        -0.15                     
CISPEP  58 GLN 2  353    ASP 2  354          0        -7.66                     
CISPEP  59 SER 2  355    ASN 2  356          0       -29.66                     
CISPEP  60 ILE 2  359    ARG 2  360          0       -20.91                     
CISPEP  61 ASN 2  366    CYS 2  367          0        13.91                     
CISPEP  62 SER 2  369    LYS 2  370          0        15.86                     
CISPEP  63 ASN 2  433    TYR 2  434          0         3.21                     
CISPEP  64 ASP 2  435    GLY 2  436          0        29.51                     
CISPEP  65 ASN 2  437    LEU 2  438          0       -16.99                     
CISPEP  66 LYS 2  441    ASN 2  442          0        21.54                     
CISPEP  67 GLY 2  443    PHE 2  444          0        -9.46                     
CISPEP  68 ARG 2  459    GLU 2  460          0         1.82                     
CISPEP  69 PRO 2  524    LYS 2  525          0       -19.19                     
CISPEP  70 ASN 2  528    GLY 2  529          0        -8.37                     
CISPEP  71 GLY 2  570    ALA 2  571          0        -4.24                     
CISPEP  72 ALA 2  573    VAL 2  574          0        -2.48                     
CISPEP  73 LYS 2  582    ASP 2  583          0        25.24                     
CISPEP  74 PRO 2  584    ILE 2  585          0        10.24                     
CISPEP  75 ILE 2  585    THR 2  586          0        12.83                     
CISPEP  76 THR 2  586    LYS 2  587          0        -9.34                     
CISPEP  77 LYS 2  633    ALA 2  634          0       -14.73                     
CISPEP  78 ARG 2  684    ASP 2  685          0         7.37                     
CISPEP  79 SER 2  802    PHE 2  803          0       -20.33                     
CISPEP  80 PHE 2  803    PRO 2  804          0       -15.83                     
CISPEP  81 PHE 3   31    LEU 3   32          0         6.47                     
CISPEP  82 THR 3   34    PHE 3   35          0         0.39                     
CISPEP  83 GLY 3  159    SER 3  160          0        -1.82                     
CISPEP  84 PHE 3  161    GLY 3  162          0         1.96                     
CISPEP  85 ALA 3  163    HIS 3  164          0        28.37                     
CISPEP  86 THR 3  172    ALA 3  173          0       -23.52                     
CISPEP  87 THR 3  187    LYS 3  188          0        -4.93                     
CISPEP  88 ALA 3  204    LYS 3  205          0         4.82                     
CISPEP  89 THR 3  236    GLU 3  237          0         1.75                     
CISPEP  90 GLY 3  323    ASN 3  324          0        -7.87                     
CISPEP  91 ALA 3  338    ARG 3  339          0         1.63                     
CISPEP  92 ARG 3  339    GLN 3  340          0        -1.60                     
CISPEP  93 ARG 3  435    GLY 3  436          0        -1.10                     
CISPEP  94 SER 3  437    SER 3  438          0       -18.25                     
CISPEP  95 THR 3  447    THR 3  448          0        -4.28                     
CISPEP  96 ARG 3  450    GLU 3  451          0        14.65                     
CISPEP  97 ALA 3  500    GLY 3  501          0         4.38                     
CISPEP  98 PRO 3  536    ASP 3  537          0        -1.89                     
CISPEP  99 ARG 3  666    VAL 3  667          0        -6.31                     
CISPEP 100 SER 3  695    PRO 3  696          0         2.08                     
CISPEP 101 ALA 4  245    ARG 4  246          0        28.31                     
CISPEP 102 LEU 4  249    ALA 4  250          0         0.20                     
CISPEP 103 LYS 4  252    GLN 4  253          0         3.09                     
CISPEP 104 ASP 4  292    LEU 4  293          0       -17.01                     
CISPEP 105 VAL 4  351    CYS 4  352          0         2.59                     
CISPEP 106 CYS 4  352    ASP 4  353          0         0.15                     
CISPEP 107 ARG 4  370    CYS 4  371          0       -17.97                     
CISPEP 108 ASP 4  375    CYS 4  376          0         9.25                     
CISPEP 109 CYS 4  376    ASN 4  377          0       -18.04                     
CISPEP 110 ASN 4  377    GLU 4  378          0       -22.40                     
CISPEP 111 GLY 4  679    SER 4  680          0         2.24                     
CISPEP 112 GLU 4  714    LYS 4  715          0        18.13                     
CISPEP 113 LEU 4  727    TYR 4  728          0         4.32                     
CISPEP 114 LEU 4  729    GLU 4  730          0         1.35                     
CISPEP 115 ASP 5   41    SER 5   42          0        -2.12                     
CISPEP 116 ASN 5  130    SER 5  131          0         0.49                     
CISPEP 117 GLY 5  202    ASN 5  203          0        -8.08                     
CISPEP 118 ASN 5  235    CYS 5  236          0        -1.24                     
CISPEP 119 GLY 5  237    PRO 5  238          0        -1.96                     
CISPEP 120 LEU 5  264    VAL 5  265          0        -5.01                     
CISPEP 121 GLY 5  320    VAL 5  321          0         2.24                     
CISPEP 122 LEU 5  331    GLY 5  332          0       -18.33                     
CISPEP 123 VAL 5  337    GLU 5  338          0         1.42                     
CISPEP 124 GLU 5  338    THR 5  339          0         1.46                     
CISPEP 125 PRO 5  401    ASP 5  402          0         4.22                     
CISPEP 126 GLY 5  408    ASP 5  409          0        -5.97                     
CISPEP 127 GLY 5  441    LYS 5  442          0         9.65                     
CISPEP 128 SER 5  444    SER 5  445          0       -18.90                     
CISPEP 129 THR 5  577    GLY 5  578          0        16.61                     
CISPEP 130 GLY 6  130    GLU 6  131          0         2.02                     
CISPEP 131 LYS 6  134    VAL 6  135          0       -15.07                     
CISPEP 132 MET 6  313    CYS 6  314          0        -3.74                     
CISPEP 133 LYS 6  326    TYR 6  327          0         3.59                     
CISPEP 134 THR 6  328    GLU 6  329          0        -0.28                     
CISPEP 135 PRO 6  334    ASN 6  335          0        -2.89                     
CISPEP 136 ASN 6  335    PRO 6  336          0        -1.32                     
CISPEP 137 PRO 6  336    SER 6  337          0        -3.51                     
CISPEP 138 ASN 6  340    ARG 6  341          0        -4.81                     
CISPEP 139 TRP 6  344    THR 6  345          0       -29.79                     
CISPEP 140 ASP 6  355    TRP 6  356          0       -23.62                     
CISPEP 141 THR 6  370    GLY 6  371          0        -5.59                     
CISPEP 142 LEU 6  412    PRO 6  413          0       -12.55                     
CISPEP 143 GLY 6  414    VAL 6  415          0        25.58                     
CISPEP 144 SER 6  558    THR 6  559          0       -23.19                     
CISPEP 145 GLU 6  561    GLY 6  562          0        -7.56                     
CISPEP 146 ARG 6  566    GLY 6  567          0         0.17                     
CISPEP 147 SER 6  603    SER 6  604          0         6.42                     
CISPEP 148 ALA 6  606    GLY 6  607          0       -12.44                     
CISPEP 149 ALA 6  611    VAL 6  612          0        -8.78                     
CISPEP 150 ARG 6  614    ASP 6  615          0         7.65                     
CISPEP 151 GLU 6  616    GLU 6  617          0         4.29                     
CISPEP 152 ALA 6  625    GLY 6  626          0       -13.91                     
CISPEP 153 TYR 6  689    ASN 6  690          0        10.35                     
CISPEP 154 ASP 6  710    LEU 6  711          0        -9.21                     
CISPEP 155 ARG 6  738    ASP 6  739          0         2.37                     
CISPEP 156 GLN 6  786    GLY 6  787          0        -0.72                     
CISPEP 157 SER 6  792    TYR 6  793          0        14.47                     
CISPEP 158 ARG 6  794    ILE 6  795          0        10.55                     
CISPEP 159 LEU 7   94    GLN 7   95          0        22.09                     
CISPEP 160 GLY 7   96    THR 7   97          0         1.84                     
CISPEP 161 PRO 7  128    THR 7  129          0       -27.29                     
CISPEP 162 LYS 7  135    ASP 7  136          0         0.13                     
CISPEP 163 SER 7  208    GLN 7  209          0       -16.77                     
CISPEP 164 ARG 7  214    TYR 7  215          0         0.03                     
CISPEP 165 PRO 7  359    TYR 7  360          0       -10.42                     
CISPEP 166 GLY 7  362    PHE 7  363          0        20.90                     
CISPEP 167 LYS 7  367    ALA 7  368          0         3.43                     
CISPEP 168 ALA 7  368    GLY 7  369          0        27.24                     
CISPEP 169 GLY 7  369    LEU 7  370          0        13.17                     
CISPEP 170 LEU 7  393    THR 7  394          0        -2.55                     
CISPEP 171 GLY 7  439    VAL 7  440          0        -5.26                     
CISPEP 172 ASP 7  446    GLY 7  447          0       -12.37                     
CISPEP 173 ARG 7  451    GLY 7  452          0         0.23                     
CISPEP 174 ASP 7  461    PRO 7  462          0         0.46                     
CISPEP 175 ASP 7  504    GLU 7  505          0         0.49                     
CISPEP 176 TYR 7  571    GLY 7  572          0        -9.29                     
CISPEP 177 VAL 7  619    HIS 7  620          0        24.03                     
CISPEP 178 LEU 7  628    ASP 7  629          0        -5.14                     
CISPEP 179 SER 7  680    PHE 7  681          0       -28.62                     
CISPEP 180 GLY 7  682    GLN 7  683          0        -9.21                     
SITE     1 AC1 17 ILE 2 505  GLY 2 507  ASP 2 544  PRO 2 545                    
SITE     2 AC1 17 GLY 2 546  THR 2 547  ALA 2 548  LYS 2 549                    
SITE     3 AC1 17 SER 2 550  GLN 2 551  GLU 2 608  LEU 2 695                    
SITE     4 AC1 17 HIS 6 653  GLU 6 657  PRO 6 704  ARG 6 708                    
SITE     5 AC1 17 ARG 6 798                                                     
SITE     1 AC2 15 SER 3 370  ILE 3 371  TYR 3 372  PRO 3 411                    
SITE     2 AC2 15 SER 3 412  THR 3 413  ALA 3 414  LYS 3 415                    
SITE     3 AC2 15 SER 3 416  GLN 3 417  ASN 3 517  GLU 5 498                    
SITE     4 AC2 15 GLN 5 499  ILE 5 650  ARG 5 651                               
SITE     1 AC3 16 HIS 2 621  GLU 2 625  ARG 2 676  VAL 2 807                    
SITE     2 AC3 16 ARG 2 808  SER 5 377  ILE 5 378  PHE 5 379                    
SITE     3 AC3 16 PRO 5 418  GLY 5 419  THR 5 420  ALA 5 421                    
SITE     4 AC3 16 LYS 5 422  SER 5 423  GLN 5 424  ASN 5 524                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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