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Database: PDB
Entry: 5VHF
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HEADER    HYDROLASE                               13-APR-17   5VHF              
TITLE     CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY 
TITLE    2 PARTICLE                                                             
CAVEAT     5VHF    ENTRY CONTAINS IMPROPER PEPTIDE LINKAGES.                    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10;           
COMPND   3 CHAIN: G;                                                            
COMPND   4 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT P28,GANKYRIN,P28(GANK);   
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 7;                       
COMPND   8 CHAIN: A;                                                            
COMPND   9 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT1,PROTEASOME 26S       
COMPND  10 SUBUNIT ATPASE 2,PROTEIN MSS1;                                       
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 4;                       
COMPND  14 CHAIN: B;                                                            
COMPND  15 SYNONYM: P26S4,26S PROTEASOME AAA-ATPASE SUBUNIT RPT2,PROTEASOME 26S 
COMPND  16 SUBUNIT ATPASE 1;                                                    
COMPND  17 ENGINEERED: YES;                                                     
COMPND  18 MOL_ID: 4;                                                           
COMPND  19 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 8;                       
COMPND  20 CHAIN: C;                                                            
COMPND  21 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT6,PROTEASOME 26S       
COMPND  22 SUBUNIT ATPASE 5,PROTEASOME SUBUNIT P45,THYROID HORMONE RECEPTOR-    
COMPND  23 INTERACTING PROTEIN 1,TRIP1,P45/SUG;                                 
COMPND  24 ENGINEERED: YES;                                                     
COMPND  25 MOL_ID: 5;                                                           
COMPND  26 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 6B;                      
COMPND  27 CHAIN: D;                                                            
COMPND  28 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT3,MB67-INTERACTING     
COMPND  29 PROTEIN,MIP224,PROTEASOME 26S SUBUNIT ATPASE 4,TAT-BINDING PROTEIN 7,
COMPND  30 TBP-7;                                                               
COMPND  31 ENGINEERED: YES;                                                     
COMPND  32 MOL_ID: 6;                                                           
COMPND  33 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 10B;                     
COMPND  34 CHAIN: E;                                                            
COMPND  35 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT4,PROTEASOME 26S       
COMPND  36 SUBUNIT ATPASE 6,PROTEASOME SUBUNIT P42;                             
COMPND  37 ENGINEERED: YES;                                                     
COMPND  38 MOL_ID: 7;                                                           
COMPND  39 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 6A;                      
COMPND  40 CHAIN: F;                                                            
COMPND  41 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT5,PROTEASOME 26S       
COMPND  42 SUBUNIT ATPASE 3,PROTEASOME SUBUNIT P50,TAT-BINDING PROTEIN 1,TBP-1; 
COMPND  43 ENGINEERED: YES;                                                     
COMPND  44 MOL_ID: 8;                                                           
COMPND  45 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1;            
COMPND  46 CHAIN: U;                                                            
COMPND  47 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN2,26S PROTEASOME       
COMPND  48 REGULATORY SUBUNIT S1,26S PROTEASOME SUBUNIT P112;                   
COMPND  49 ENGINEERED: YES;                                                     
COMPND  50 MOL_ID: 9;                                                           
COMPND  51 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3;            
COMPND  52 CHAIN: V;                                                            
COMPND  53 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN3,26S PROTEASOME       
COMPND  54 REGULATORY SUBUNIT S3,PROTEASOME SUBUNIT P58;                        
COMPND  55 ENGINEERED: YES;                                                     
COMPND  56 MOL_ID: 10;                                                          
COMPND  57 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12;           
COMPND  58 CHAIN: W;                                                            
COMPND  59 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN5,26S PROTEASOME       
COMPND  60 REGULATORY SUBUNIT P55;                                              
COMPND  61 ENGINEERED: YES;                                                     
COMPND  62 MOL_ID: 11;                                                          
COMPND  63 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11;           
COMPND  64 CHAIN: X;                                                            
COMPND  65 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN6,26S PROTEASOME       
COMPND  66 REGULATORY SUBUNIT S9,26S PROTEASOME REGULATORY SUBUNIT P44.5;       
COMPND  67 ENGINEERED: YES;                                                     
COMPND  68 MOL_ID: 12;                                                          
COMPND  69 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6;            
COMPND  70 CHAIN: Y;                                                            
COMPND  71 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN7,26S PROTEASOME       
COMPND  72 REGULATORY SUBUNIT S10,BREAST CANCER-ASSOCIATED PROTEIN SGA-113M,    
COMPND  73 PHOSPHONOFORMATE IMMUNO-ASSOCIATED PROTEIN 4,PROTEASOME REGULATORY   
COMPND  74 PARTICLE SUBUNIT P44S10,P42A;                                        
COMPND  75 ENGINEERED: YES;                                                     
COMPND  76 MOL_ID: 13;                                                          
COMPND  77 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7;            
COMPND  78 CHAIN: Z;                                                            
COMPND  79 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN8,26S PROTEASOME       
COMPND  80 REGULATORY SUBUNIT S12,MOV34 PROTEIN HOMOLOG,PROTEASOME SUBUNIT P40; 
COMPND  81 ENGINEERED: YES;                                                     
COMPND  82 MOL_ID: 14;                                                          
COMPND  83 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13;           
COMPND  84 CHAIN: a;                                                            
COMPND  85 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN9,26S PROTEASOME       
COMPND  86 REGULATORY SUBUNIT S11,26S PROTEASOME REGULATORY SUBUNIT P40.5;      
COMPND  87 ENGINEERED: YES;                                                     
COMPND  88 MOL_ID: 15;                                                          
COMPND  89 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4;            
COMPND  90 CHAIN: b;                                                            
COMPND  91 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN10,26S PROTEASOME      
COMPND  92 REGULATORY SUBUNIT S5A,ANTISECRETORY FACTOR 1,ASF,MULTIUBIQUITIN     
COMPND  93 CHAIN-BINDING PROTEIN;                                               
COMPND  94 ENGINEERED: YES;                                                     
COMPND  95 MOL_ID: 16;                                                          
COMPND  96 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 14;           
COMPND  97 CHAIN: c;                                                            
COMPND  98 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN11,26S PROTEASOME-     
COMPND  99 ASSOCIATED PAD1 HOMOLOG 1;                                           
COMPND 100 EC: 3.4.19.-;                                                        
COMPND 101 ENGINEERED: YES;                                                     
COMPND 102 MOL_ID: 17;                                                          
COMPND 103 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8;            
COMPND 104 CHAIN: d;                                                            
COMPND 105 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN12,26S PROTEASOME      
COMPND 106 REGULATORY SUBUNIT S14,P31;                                          
COMPND 107 ENGINEERED: YES;                                                     
COMPND 108 MOL_ID: 18;                                                          
COMPND 109 MOLECULE: 26S PROTEASOME COMPLEX SUBUNIT SEM1;                       
COMPND 110 CHAIN: e;                                                            
COMPND 111 SYNONYM: 26S PROTEASOME COMPLEX SUBUNIT DSS1,DELETED IN SPLIT        
COMPND 112 HAND/SPLIT FOOT PROTEIN 1,SPLIT HAND/FOOT DELETED PROTEIN 1,SPLIT    
COMPND 113 HAND/FOOT MALFORMATION TYPE 1 PROTEIN;                               
COMPND 114 ENGINEERED: YES;                                                     
COMPND 115 MOL_ID: 19;                                                          
COMPND 116 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2;            
COMPND 117 CHAIN: f;                                                            
COMPND 118 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN1,26S PROTEASOME       
COMPND 119 REGULATORY SUBUNIT S2,26S PROTEASOME SUBUNIT P97,PROTEIN 55.11,TUMOR 
COMPND 120 NECROSIS FACTOR TYPE 1 RECEPTOR-ASSOCIATED PROTEIN 2;                
COMPND 121 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: PSMD10;                                                        
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 GENE: PSMC2, MSS1;                                                   
SOURCE  14 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  15 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  17 MOL_ID: 3;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 GENE: PSMC1;                                                         
SOURCE  22 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  23 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  24 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  25 MOL_ID: 4;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 GENE: PSMC5, SUG1;                                                   
SOURCE  30 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  31 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  32 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  33 MOL_ID: 5;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  35 ORGANISM_COMMON: HUMAN;                                              
SOURCE  36 ORGANISM_TAXID: 9606;                                                
SOURCE  37 GENE: PSMC4, MIP224, TBP7;                                           
SOURCE  38 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  39 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  40 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  41 MOL_ID: 6;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 GENE: PSMC6, SUG2;                                                   
SOURCE  46 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  47 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  48 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  49 MOL_ID: 7;                                                           
SOURCE  50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  51 ORGANISM_COMMON: HUMAN;                                              
SOURCE  52 ORGANISM_TAXID: 9606;                                                
SOURCE  53 GENE: PSMC3, TBP1;                                                   
SOURCE  54 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  55 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  56 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  57 MOL_ID: 8;                                                           
SOURCE  58 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  59 ORGANISM_COMMON: HUMAN;                                              
SOURCE  60 ORGANISM_TAXID: 9606;                                                
SOURCE  61 GENE: PSMD1;                                                         
SOURCE  62 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  63 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  64 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  65 MOL_ID: 9;                                                           
SOURCE  66 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  67 ORGANISM_COMMON: HUMAN;                                              
SOURCE  68 ORGANISM_TAXID: 9606;                                                
SOURCE  69 GENE: PSMD3;                                                         
SOURCE  70 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  71 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  72 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  73 MOL_ID: 10;                                                          
SOURCE  74 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  75 ORGANISM_COMMON: HUMAN;                                              
SOURCE  76 ORGANISM_TAXID: 9606;                                                
SOURCE  77 GENE: PSMD12;                                                        
SOURCE  78 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  79 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  80 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  81 MOL_ID: 11;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  83 ORGANISM_COMMON: HUMAN;                                              
SOURCE  84 ORGANISM_TAXID: 9606;                                                
SOURCE  85 GENE: PSMD11;                                                        
SOURCE  86 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  87 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  88 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  89 MOL_ID: 12;                                                          
SOURCE  90 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  91 ORGANISM_COMMON: HUMAN;                                              
SOURCE  92 ORGANISM_TAXID: 9606;                                                
SOURCE  93 GENE: PSMD6, KIAA0107, PFAAP4;                                       
SOURCE  94 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  95 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  96 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  97 MOL_ID: 13;                                                          
SOURCE  98 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  99 ORGANISM_COMMON: HUMAN;                                              
SOURCE 100 ORGANISM_TAXID: 9606;                                                
SOURCE 101 GENE: PSMD7, MOV34L;                                                 
SOURCE 102 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE 103 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE 104 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE 105 MOL_ID: 14;                                                          
SOURCE 106 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 107 ORGANISM_COMMON: HUMAN;                                              
SOURCE 108 ORGANISM_TAXID: 9606;                                                
SOURCE 109 GENE: PSMD13;                                                        
SOURCE 110 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE 111 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE 112 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE 113 MOL_ID: 15;                                                          
SOURCE 114 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 115 ORGANISM_COMMON: HUMAN;                                              
SOURCE 116 ORGANISM_TAXID: 9606;                                                
SOURCE 117 GENE: PSMD4, MCB1;                                                   
SOURCE 118 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE 119 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE 120 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE 121 MOL_ID: 16;                                                          
SOURCE 122 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 123 ORGANISM_COMMON: HUMAN;                                              
SOURCE 124 ORGANISM_TAXID: 9606;                                                
SOURCE 125 GENE: PSMD14, POH1;                                                  
SOURCE 126 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE 127 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE 128 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE 129 MOL_ID: 17;                                                          
SOURCE 130 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 131 ORGANISM_COMMON: HUMAN;                                              
SOURCE 132 ORGANISM_TAXID: 9606;                                                
SOURCE 133 GENE: PSMD8;                                                         
SOURCE 134 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE 135 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE 136 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE 137 MOL_ID: 18;                                                          
SOURCE 138 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 139 ORGANISM_COMMON: HUMAN;                                              
SOURCE 140 ORGANISM_TAXID: 9606;                                                
SOURCE 141 GENE: SEM1, C7ORF76, DSS1, SHFDG1, SHFM1;                            
SOURCE 142 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE 143 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE 144 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE 145 MOL_ID: 19;                                                          
SOURCE 146 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 147 ORGANISM_COMMON: HUMAN;                                              
SOURCE 148 ORGANISM_TAXID: 9606;                                                
SOURCE 149 GENE: PSMD2, TRAP2;                                                  
SOURCE 150 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE 151 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE 152 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    P28, 26S PROTEASOME, REGULATORY PARTICLE, 19S, GANKYRIN, HYDROLASE    
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    Y.LU,J.WU,Y.DONG,S.CHEN,S.SUN,Y.B.MA,Q.OUYANG,D.FINLEY,M.W.KIRSCHNER, 
AUTHOR   2 Y.MAO                                                                
REVDAT   2   22-AUG-18 5VHF    1       REMARK                                   
REVDAT   1   23-AUG-17 5VHF    0                                                
JRNL        AUTH   Y.LU,J.WU,Y.DONG,S.CHEN,S.SUN,Y.B.MA,Q.OUYANG,D.FINLEY,      
JRNL        AUTH 2 M.W.KIRSCHNER,Y.MAO                                          
JRNL        TITL   CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME   
JRNL        TITL 2 REGULATORY PARTICLE.                                         
JRNL        REF    MOL. CELL                     V.  67   322 2017              
JRNL        REFN                   ISSN 1097-4164                               
JRNL        PMID   28689658                                                     
JRNL        DOI    10.1016/J.MOLCEL.2017.06.007                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    5.70 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 5.700                          
REMARK   3   NUMBER OF PARTICLES               : 39520                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5VHF COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-APR-17.                  
REMARK 100 THE DEPOSITION ID IS D_1000227415.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : PROTEASOME REGULATORY PARTICLE    
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI ARCTICA             
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 50.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONADECAMERIC                     
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, A, B, C, D, E, F, U, V, W,         
REMARK 350                    AND CHAINS: X, Y, Z, a, b, c, d, e, f             
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     CYS G     4                                                      
REMARK 465     VAL G     5                                                      
REMARK 465     SER G     6                                                      
REMARK 465     ASN G     7                                                      
REMARK 465     LYS A   156                                                      
REMARK 465     ILE A   157                                                      
REMARK 465     ASP A   158                                                      
REMARK 465     ALA A   283                                                      
REMARK 465     ARG A   284                                                      
REMARK 465     PHE A   285                                                      
REMARK 465     ASP A   286                                                      
REMARK 465     ASP A   287                                                      
REMARK 465     GLY A   288                                                      
REMARK 465     ALA A   289                                                      
REMARK 465     GLY A   290                                                      
REMARK 465     ASP B   166                                                      
REMARK 465     THR B   167                                                      
REMARK 465     LYS B   293                                                      
REMARK 465     ARG B   294                                                      
REMARK 465     TYR B   295                                                      
REMARK 465     ASP B   296                                                      
REMARK 465     SER B   297                                                      
REMARK 465     ASN B   298                                                      
REMARK 465     SER B   299                                                      
REMARK 465     GLY B   300                                                      
REMARK 465     ASN C   129                                                      
REMARK 465     LYS C   130                                                      
REMARK 465     VAL C   131                                                      
REMARK 465     ASP C   132                                                      
REMARK 465     PRO C   133                                                      
REMARK 465     LEU C   134                                                      
REMARK 465     VAL C   135                                                      
REMARK 465     SER C   136                                                      
REMARK 465     LEU C   137                                                      
REMARK 465     MET C   138                                                      
REMARK 465     MET C   139                                                      
REMARK 465     VAL C   140                                                      
REMARK 465     GLU C   141                                                      
REMARK 465     LYS C   142                                                      
REMARK 465     VAL C   143                                                      
REMARK 465     PRO C   144                                                      
REMARK 465     ASP C   145                                                      
REMARK 465     SER C   146                                                      
REMARK 465     THR C   147                                                      
REMARK 465     TYR C   148                                                      
REMARK 465     GLU C   149                                                      
REMARK 465     MET C   150                                                      
REMARK 465     ILE C   151                                                      
REMARK 465     GLY C   152                                                      
REMARK 465     GLY C   153                                                      
REMARK 465     GLY C   216                                                      
REMARK 465     SER C   217                                                      
REMARK 465     GLU C   218                                                      
REMARK 465     LEU C   219                                                      
REMARK 465     VAL C   220                                                      
REMARK 465     GLN C   221                                                      
REMARK 465     LYS C   222                                                      
REMARK 465     PHE C   223                                                      
REMARK 465     ILE C   224                                                      
REMARK 465     GLY C   225                                                      
REMARK 465     GLU C   226                                                      
REMARK 465     GLY C   227                                                      
REMARK 465     ALA C   228                                                      
REMARK 465     ILE C   254                                                      
REMARK 465     GLY C   255                                                      
REMARK 465     SER C   256                                                      
REMARK 465     SER C   257                                                      
REMARK 465     SER C   395                                                      
REMARK 465     GLU D   146                                                      
REMARK 465     ALA D   147                                                      
REMARK 465     ASP D   148                                                      
REMARK 465     SER D   149                                                      
REMARK 465     SER D   150                                                      
REMARK 465     ILE D   151                                                      
REMARK 465     MET D   152                                                      
REMARK 465     MET D   153                                                      
REMARK 465     LEU D   154                                                      
REMARK 465     THR D   155                                                      
REMARK 465     SER D   156                                                      
REMARK 465     ASP D   157                                                      
REMARK 465     GLN D   158                                                      
REMARK 465     LYS D   159                                                      
REMARK 465     PRO D   160                                                      
REMARK 465     ASP D   161                                                      
REMARK 465     VAL D   162                                                      
REMARK 465     MET D   163                                                      
REMARK 465     TYR D   164                                                      
REMARK 465     ALA D   165                                                      
REMARK 465     ASP D   166                                                      
REMARK 465     ILE D   167                                                      
REMARK 465     GLY D   168                                                      
REMARK 465     GLY D   169                                                      
REMARK 465     GLU E   140                                                      
REMARK 465     GLN E   141                                                      
REMARK 465     ILE E   142                                                      
REMARK 465     ARG E   143                                                      
REMARK 465     GLU E   144                                                      
REMARK 465     LEU E   145                                                      
REMARK 465     ARG E   146                                                      
REMARK 465     GLU E   147                                                      
REMARK 465     VAL E   148                                                      
REMARK 465     ILE E   149                                                      
REMARK 465     GLU E   150                                                      
REMARK 465     LEU E   151                                                      
REMARK 465     PRO E   152                                                      
REMARK 465     LEU E   153                                                      
REMARK 465     THR E   154                                                      
REMARK 465     ASN E   155                                                      
REMARK 465     PRO E   156                                                      
REMARK 465     GLU E   157                                                      
REMARK 465     LEU E   158                                                      
REMARK 465     PHE E   159                                                      
REMARK 465     GLN E   160                                                      
REMARK 465     ARG E   161                                                      
REMARK 465     VAL E   162                                                      
REMARK 465     GLY E   163                                                      
REMARK 465     ILE E   164                                                      
REMARK 465     ILE E   165                                                      
REMARK 465     PRO E   166                                                      
REMARK 465     PRO E   167                                                      
REMARK 465     LEU E   384                                                      
REMARK 465     ASP E   385                                                      
REMARK 465     TYR E   386                                                      
REMARK 465     LYS E   387                                                      
REMARK 465     PRO E   388                                                      
REMARK 465     VAL E   389                                                      
REMARK 465     ASN F   102                                                      
REMARK 465     ASP F   103                                                      
REMARK 465     GLN F   104                                                      
REMARK 465     GLU F   105                                                      
REMARK 465     GLU F   106                                                      
REMARK 465     ASP F   107                                                      
REMARK 465     GLY F   108                                                      
REMARK 465     ALA F   109                                                      
REMARK 465     ASN F   110                                                      
REMARK 465     ILE F   111                                                      
REMARK 465     ASP F   112                                                      
REMARK 465     LEU F   113                                                      
REMARK 465     ASP F   114                                                      
REMARK 465     SER F   115                                                      
REMARK 465     ASP F   297                                                      
REMARK 465     SER F   298                                                      
REMARK 465     GLU F   299                                                      
REMARK 465     ALA F   429                                                      
REMARK 465     LYS F   430                                                      
REMARK 465     LYS F   431                                                      
REMARK 465     LYS F   432                                                      
REMARK 465     ILE U   275                                                      
REMARK 465     ALA U   276                                                      
REMARK 465     SER U   277                                                      
REMARK 465     VAL U   278                                                      
REMARK 465     PRO U   279                                                      
REMARK 465     GLY U   280                                                      
REMARK 465     SER U   281                                                      
REMARK 465     THR U   282                                                      
REMARK 465     ASN U   283                                                      
REMARK 465     THR U   284                                                      
REMARK 465     GLY U   285                                                      
REMARK 465     THR U   286                                                      
REMARK 465     VAL U   287                                                      
REMARK 465     PRO U   288                                                      
REMARK 465     GLY U   289                                                      
REMARK 465     SER U   290                                                      
REMARK 465     GLU U   291                                                      
REMARK 465     LYS U   292                                                      
REMARK 465     ASP U   293                                                      
REMARK 465     SER U   294                                                      
REMARK 465     ASP U   295                                                      
REMARK 465     SER U   296                                                      
REMARK 465     MET U   297                                                      
REMARK 465     GLU U   298                                                      
REMARK 465     THR U   299                                                      
REMARK 465     GLU U   300                                                      
REMARK 465     GLU U   301                                                      
REMARK 465     LYS U   302                                                      
REMARK 465     THR U   303                                                      
REMARK 465     SER U   304                                                      
REMARK 465     SER U   305                                                      
REMARK 465     ALA U   306                                                      
REMARK 465     PHE U   307                                                      
REMARK 465     VAL U   308                                                      
REMARK 465     GLY U   309                                                      
REMARK 465     LYS U   310                                                      
REMARK 465     THR U   311                                                      
REMARK 465     PRO U   312                                                      
REMARK 465     GLU U   313                                                      
REMARK 465     ALA U   314                                                      
REMARK 465     SER U   315                                                      
REMARK 465     PRO U   316                                                      
REMARK 465     LYS U   821                                                      
REMARK 465     GLU U   822                                                      
REMARK 465     LYS U   823                                                      
REMARK 465     GLU U   824                                                      
REMARK 465     LYS U   825                                                      
REMARK 465     GLU U   826                                                      
REMARK 465     LYS U   827                                                      
REMARK 465     VAL U   828                                                      
REMARK 465     SER U   829                                                      
REMARK 465     THR U   830                                                      
REMARK 465     ALA U   831                                                      
REMARK 465     VAL U   832                                                      
REMARK 465     LEU U   833                                                      
REMARK 465     GLU U   845                                                      
REMARK 465     LYS U   846                                                      
REMARK 465     GLU U   847                                                      
REMARK 465     LYS U   848                                                      
REMARK 465     LYS U   849                                                      
REMARK 465     GLU U   850                                                      
REMARK 465     GLU U   851                                                      
REMARK 465     GLU U   852                                                      
REMARK 465     LYS U   853                                                      
REMARK 465     MET U   854                                                      
REMARK 465     GLU U   855                                                      
REMARK 465     VAL U   856                                                      
REMARK 465     ASP U   857                                                      
REMARK 465     GLU U   858                                                      
REMARK 465     ALA U   859                                                      
REMARK 465     GLU U   860                                                      
REMARK 465     LYS U   861                                                      
REMARK 465     LYS U   862                                                      
REMARK 465     GLU U   863                                                      
REMARK 465     GLU U   864                                                      
REMARK 465     LYS U   865                                                      
REMARK 465     GLU U   866                                                      
REMARK 465     LYS U   867                                                      
REMARK 465     LYS U   868                                                      
REMARK 465     LYS U   869                                                      
REMARK 465     GLU U   870                                                      
REMARK 465     PRO U   871                                                      
REMARK 465     GLU U   872                                                      
REMARK 465     PRO U   873                                                      
REMARK 465     ASN U   874                                                      
REMARK 465     PHE U   875                                                      
REMARK 465     GLN U   876                                                      
REMARK 465     LEU U   877                                                      
REMARK 465     LEU U   878                                                      
REMARK 465     ASP U   879                                                      
REMARK 465     LEU f    56                                                      
REMARK 465     GLU f    57                                                      
REMARK 465     MET f    58                                                      
REMARK 465     LEU f    59                                                      
REMARK 465     VAL f    60                                                      
REMARK 465     GLU f    61                                                      
REMARK 465     ARG f    62                                                      
REMARK 465     LEU f    63                                                      
REMARK 465     GLY f    64                                                      
REMARK 465     GLU f    65                                                      
REMARK 465     LYS f    66                                                      
REMARK 465     ASP f    67                                                      
REMARK 465     THR f    68                                                      
REMARK 465     SER f    69                                                      
REMARK 465     GLY f   104                                                      
REMARK 465     LYS f   105                                                      
REMARK 465     LEU f   106                                                      
REMARK 465     LYS f   107                                                      
REMARK 465     GLU f   108                                                      
REMARK 465     ILE f   109                                                      
REMARK 465     TYR f   110                                                      
REMARK 465     GLU f   111                                                      
REMARK 465     ASN f   112                                                      
REMARK 465     MET f   113                                                      
REMARK 465     ALA f   114                                                      
REMARK 465     PRO f   115                                                      
REMARK 465     GLY f   116                                                      
REMARK 465     GLU f   117                                                      
REMARK 465     SER f   147                                                      
REMARK 465     GLN f   148                                                      
REMARK 465     GLU f   149                                                      
REMARK 465     GLU f   150                                                      
REMARK 465     LEU f   151                                                      
REMARK 465     ALA f   152                                                      
REMARK 465     SER f   153                                                      
REMARK 465     TRP f   154                                                      
REMARK 465     GLY f   155                                                      
REMARK 465     HIS f   156                                                      
REMARK 465     GLU f   157                                                      
REMARK 465     TYR f   158                                                      
REMARK 465     VAL f   159                                                      
REMARK 465     ARG f   160                                                      
REMARK 465     HIS f   161                                                      
REMARK 465     LEU f   162                                                      
REMARK 465     TYR f   194                                                      
REMARK 465     ASN f   195                                                      
REMARK 465     MET f   196                                                      
REMARK 465     ALA f   197                                                      
REMARK 465     HIS f   198                                                      
REMARK 465     ASN f   199                                                      
REMARK 465     ALA f   200                                                      
REMARK 465     GLU f   201                                                      
REMARK 465     HIS f   202                                                      
REMARK 465     GLU f   203                                                      
REMARK 465     ALA f   204                                                      
REMARK 465     CYS f   205                                                      
REMARK 465     ASP f   206                                                      
REMARK 465     VAL f   290                                                      
REMARK 465     GLN f   291                                                      
REMARK 465     LYS f   292                                                      
REMARK 465     GLN f   293                                                      
REMARK 465     MET f   294                                                      
REMARK 465     ALA f   295                                                      
REMARK 465     PHE f   296                                                      
REMARK 465     ALA f   383                                                      
REMARK 465     ALA f   384                                                      
REMARK 465     PHE f   385                                                      
REMARK 465     GLY f   386                                                      
REMARK 465     ALA f   490                                                      
REMARK 465     GLY f   491                                                      
REMARK 465     SER f   492                                                      
REMARK 465     SER f   700                                                      
REMARK 465     ASN f   701                                                      
REMARK 465     PRO f   702                                                      
REMARK 465     ARG f   703                                                      
REMARK 465     LEU f   704                                                      
REMARK 465     ASN f   705                                                      
REMARK 465     ILE f   706                                                      
REMARK 465     LEU f   707                                                      
REMARK 465     ASP f   708                                                      
REMARK 465     THR f   709                                                      
REMARK 465     LEU f   710                                                      
REMARK 465     SER f   711                                                      
REMARK 465     LYS f   712                                                      
REMARK 465     PHE f   713                                                      
REMARK 465     MET f   729                                                      
REMARK 465     GLY f   730                                                      
REMARK 465     MET f   731                                                      
REMARK 465     VAL f   732                                                      
REMARK 465     GLY f   733                                                      
REMARK 465     SER f   734                                                      
REMARK 465     GLY f   735                                                      
REMARK 465     THR f   736                                                      
REMARK 465     ASN f   737                                                      
REMARK 465     ASN f   738                                                      
REMARK 465     ASP f   755                                                      
REMARK 465     PRO f   756                                                      
REMARK 465     ASN f   757                                                      
REMARK 465     ASN f   758                                                      
REMARK 465     LEU f   759                                                      
REMARK 465     PHE f   760                                                      
REMARK 465     MET f   761                                                      
REMARK 465     VAL f   762                                                      
REMARK 465     ARG f   763                                                      
REMARK 465     LEU f   764                                                      
REMARK 465     ALA f   765                                                      
REMARK 465     GLN f   766                                                      
REMARK 465     GLY f   767                                                      
REMARK 465     LEU f   768                                                      
REMARK 465     THR f   769                                                      
REMARK 465     HIS f   770                                                      
REMARK 465     LEU f   771                                                      
REMARK 465     GLY f   772                                                      
REMARK 465     ASP f   805                                                      
REMARK 465     VAL f   806                                                      
REMARK 465     ARG f   807                                                      
REMARK 465     ASN f   808                                                      
REMARK 465     ILE f   809                                                      
REMARK 465     ILE f   810                                                      
REMARK 465     LEU f   811                                                      
REMARK 465     GLY f   812                                                      
REMARK 465     LYS f   813                                                      
REMARK 465     SER f   814                                                      
REMARK 465     HIS f   815                                                      
REMARK 465     TYR f   816                                                      
REMARK 465     VAL f   817                                                      
REMARK 465     LEU f   818                                                      
REMARK 465     TYR f   819                                                      
REMARK 465     GLY f   820                                                      
REMARK 465     LEU f   821                                                      
REMARK 465     VAL f   822                                                      
REMARK 465     ALA f   823                                                      
REMARK 465     ALA f   824                                                      
REMARK 465     MET f   825                                                      
REMARK 465     GLN f   826                                                      
REMARK 465     PRO f   827                                                      
REMARK 465     ARG f   828                                                      
REMARK 465     MET f   829                                                      
REMARK 465     LEU f   830                                                      
REMARK 465     VAL f   831                                                      
REMARK 465     THR f   832                                                      
REMARK 465     PHE f   833                                                      
REMARK 465     ASP f   834                                                      
REMARK 465     GLU f   835                                                      
REMARK 465     GLU f   836                                                      
REMARK 465     LEU f   837                                                      
REMARK 465     ARG f   838                                                      
REMARK 465     PRO f   839                                                      
REMARK 465     LEU f   840                                                      
REMARK 465     PRO f   841                                                      
REMARK 465     VAL f   842                                                      
REMARK 465     SER f   843                                                      
REMARK 465     VAL f   844                                                      
REMARK 465     ARG f   845                                                      
REMARK 465     VAL f   846                                                      
REMARK 465     GLY f   847                                                      
REMARK 465     GLN f   848                                                      
REMARK 465     ALA f   849                                                      
REMARK 465     VAL f   850                                                      
REMARK 465     ASP f   851                                                      
REMARK 465     VAL f   852                                                      
REMARK 465     VAL f   853                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    ASP B   168     N    LEU B   170              1.37            
REMARK 500   OD2  ASP B   168     CG2  VAL B   171              1.41            
REMARK 500   CB   LEU F   150     OG1  THR F   166              2.00            
REMARK 500   CG   ASP B   168     CG2  VAL B   171              2.03            
REMARK 500   OD1  ASP c    63     OG1  THR c    66              2.12            
REMARK 500   CA   GLY f   486     CD1  TYR f   489              2.14            
REMARK 500   O    LYS A   415     OG   SER A   419              2.16            
REMARK 500   O    ASP f   347     OG1  THR f   351              2.17            
REMARK 500   O    LEU f   485     CD1  TYR f   489              2.18            
REMARK 500   O    SER U   581     OG1  THR U   585              2.19            
REMARK 500   O    ILE F    73     OG   SER F    77              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    VAL E 115   N     VAL E 115   CA      0.169                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO B 169   C   -  N   -  CA  ANGL. DEV. = -16.1 DEGREES          
REMARK 500    VAL E 115   CA  -  C   -  N   ANGL. DEV. =  16.7 DEGREES          
REMARK 500    ASP E 116   C   -  N   -  CA  ANGL. DEV. = -20.4 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ARG A  97       41.29   -105.46                                   
REMARK 500    LYS A 222       -6.48     72.66                                   
REMARK 500    LYS A 267       30.98    -92.60                                   
REMARK 500    ARG A 312      147.39   -173.98                                   
REMARK 500    ARG A 339       64.25     61.09                                   
REMARK 500    ASN B 119       13.43     56.89                                   
REMARK 500    LEU B 136     -169.07   -125.98                                   
REMARK 500    PHE B 138       -4.71     68.99                                   
REMARK 500    LYS B 141       -3.04     63.79                                   
REMARK 500    GLU B 145       76.08     53.78                                   
REMARK 500    VAL B 156        2.91    -61.51                                   
REMARK 500    HIS B 157       42.79     70.93                                   
REMARK 500    ASP B 168       19.51     58.88                                   
REMARK 500    PRO B 169       -6.45    -26.44                                   
REMARK 500    LEU B 205       -8.40     72.04                                   
REMARK 500    LYS B 217       74.68     52.91                                   
REMARK 500    ASP B 348      -62.50    -91.74                                   
REMARK 500    ASP B 357      -61.01    -95.41                                   
REMARK 500    LEU C 174       -8.60    -59.10                                   
REMARK 500    ARG C 297     -164.80   -125.24                                   
REMARK 500    ASP C 299        0.56    -65.86                                   
REMARK 500    PRO C 308       43.22    -79.75                                   
REMARK 500    LEU C 350       31.71    -99.74                                   
REMARK 500    SER C 355     -166.74   -160.37                                   
REMARK 500    ASP D 171       -7.72     70.84                                   
REMARK 500    GLU D 189       11.98     58.07                                   
REMARK 500    PRO D 198       34.77    -90.89                                   
REMARK 500    PRO D 199       48.63    -69.63                                   
REMARK 500    LYS D 212       -3.24     64.66                                   
REMARK 500    THR D 279       38.75    -99.94                                   
REMARK 500    ASP D 337       58.15    -97.29                                   
REMARK 500    ASP D 374       56.47     33.91                                   
REMARK 500    GLU D 389       -6.84     72.68                                   
REMARK 500    THR E 104       -3.63     67.94                                   
REMARK 500    GLU E 114     -128.09   -150.75                                   
REMARK 500    PRO E 176       69.19    -68.13                                   
REMARK 500    LEU E 191      -64.06   -126.14                                   
REMARK 500    ASP E 192      -11.25     64.25                                   
REMARK 500    CYS E 193       -7.29     63.93                                   
REMARK 500    ASN E 194     -169.32   -171.55                                   
REMARK 500    ARG E 242       43.68     39.75                                   
REMARK 500    PRO E 282       49.91    -86.72                                   
REMARK 500    LEU E 285       35.72    -97.16                                   
REMARK 500    ASP E 286       76.48     54.56                                   
REMARK 500    ASP E 358       46.94     36.45                                   
REMARK 500    LYS F  84       33.05    -95.69                                   
REMARK 500    GLU F 167     -106.23    -94.98                                   
REMARK 500    TYR F 168      178.42     94.04                                   
REMARK 500    ALA F 174       57.45    -98.99                                   
REMARK 500    ALA F 201        0.45    -67.14                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     151 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN c 400                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8674   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8672   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8675   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8676   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8677   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8678   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8679   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8680   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8681   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8682   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8683   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8684   RELATED DB: EMDB                              
REMARK 900 RELATED ID: 5VGZ   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHH   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHI   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHJ   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHM   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHN   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHO   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHP   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHQ   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHR   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHS   RELATED DB: PDB                                   
DBREF  5VHF G    4   226  UNP    O75832   PSD10_HUMAN      4    226             
DBREF  5VHF A   73   424  UNP    P35998   PRS7_HUMAN      73    424             
DBREF  5VHF B   93   432  UNP    P62191   PRS4_HUMAN      93    432             
DBREF  5VHF C   11   395  UNP    P62195   PRS8_HUMAN      11    395             
DBREF  5VHF D   39   406  UNP    P43686   PRS6B_HUMAN     39    406             
DBREF  5VHF E   11   389  UNP    P62333   PRS10_HUMAN     11    389             
DBREF  5VHF F   53   432  UNP    P17980   PRS6A_HUMAN     53    432             
DBREF  5VHF U   95   935  UNP    Q99460   PSMD1_HUMAN     95    935             
DBREF  5VHF V  323   505  UNP    O43242   PSMD3_HUMAN    323    505             
DBREF  5VHF W    1   456  UNP    O00232   PSD12_HUMAN      1    456             
DBREF  5VHF X   38   422  UNP    O00231   PSD11_HUMAN     38    422             
DBREF  5VHF Y   12   389  UNP    Q15008   PSMD6_HUMAN     12    389             
DBREF  5VHF Z    5   290  UNP    P51665   PSMD7_HUMAN      5    290             
DBREF  5VHF a    3   376  UNP    Q9UNM6   PSD13_HUMAN      3    376             
DBREF  5VHF b    1   191  UNP    P55036   PSMD4_HUMAN      1    191             
DBREF  5VHF c   24   310  UNP    O00487   PSDE_HUMAN      24    310             
DBREF  5VHF d  122   257  UNP    P48556   PSMD8_HUMAN    215    350             
DBREF  5VHF e    1    70  UNP    P60896   SEM1_HUMAN       1     70             
DBREF  5VHF f    6   853  UNP    Q13200   PSMD2_HUMAN      6    853             
SEQRES   1 G  223  CYS VAL SER ASN LEU MET VAL CYS ASN LEU ALA TYR SER          
SEQRES   2 G  223  GLY LYS LEU GLU GLU LEU LYS GLU SER ILE LEU ALA ASP          
SEQRES   3 G  223  LYS SER LEU ALA THR ARG THR ASP GLN ASP SER ARG THR          
SEQRES   4 G  223  ALA LEU HIS TRP ALA CYS SER ALA GLY HIS THR GLU ILE          
SEQRES   5 G  223  VAL GLU PHE LEU LEU GLN LEU GLY VAL PRO VAL ASN ASP          
SEQRES   6 G  223  LYS ASP ASP ALA GLY TRP SER PRO LEU HIS ILE ALA ALA          
SEQRES   7 G  223  SER ALA GLY ARG ASP GLU ILE VAL LYS ALA LEU LEU GLY          
SEQRES   8 G  223  LYS GLY ALA GLN VAL ASN ALA VAL ASN GLN ASN GLY CYS          
SEQRES   9 G  223  THR PRO LEU HIS TYR ALA ALA SER LYS ASN ARG HIS GLU          
SEQRES  10 G  223  ILE ALA VAL MET LEU LEU GLU GLY GLY ALA ASN PRO ASP          
SEQRES  11 G  223  ALA LYS ASP HIS TYR GLU ALA THR ALA MET HIS ARG ALA          
SEQRES  12 G  223  ALA ALA LYS GLY ASN LEU LYS MET ILE HIS ILE LEU LEU          
SEQRES  13 G  223  TYR TYR LYS ALA SER THR ASN ILE GLN ASP THR GLU GLY          
SEQRES  14 G  223  ASN THR PRO LEU HIS LEU ALA CYS ASP GLU GLU ARG VAL          
SEQRES  15 G  223  GLU GLU ALA LYS LEU LEU VAL SER GLN GLY ALA SER ILE          
SEQRES  16 G  223  TYR ILE GLU ASN LYS GLU GLU LYS THR PRO LEU GLN VAL          
SEQRES  17 G  223  ALA LYS GLY GLY LEU GLY LEU ILE LEU LYS ARG MET VAL          
SEQRES  18 G  223  GLU GLY                                                      
SEQRES   1 A  352  ALA PRO PRO ALA LEU TRP ASP LEU ALA ALA ASP LYS GLN          
SEQRES   2 A  352  THR LEU GLN SER GLU GLN PRO LEU GLN VAL ALA ARG CYS          
SEQRES   3 A  352  THR LYS ILE ILE ASN ALA ASP SER GLU ASP PRO LYS TYR          
SEQRES   4 A  352  ILE ILE ASN VAL LYS GLN PHE ALA LYS PHE VAL VAL ASP          
SEQRES   5 A  352  LEU SER ASP GLN VAL ALA PRO THR ASP ILE GLU GLU GLY          
SEQRES   6 A  352  MET ARG VAL GLY VAL ASP ARG ASN LYS TYR GLN ILE HIS          
SEQRES   7 A  352  ILE PRO LEU PRO PRO LYS ILE ASP PRO THR VAL THR MET          
SEQRES   8 A  352  MET GLN VAL GLU GLU LYS PRO ASP VAL THR TYR SER ASP          
SEQRES   9 A  352  VAL GLY GLY CYS LYS GLU GLN ILE GLU LYS LEU ARG GLU          
SEQRES  10 A  352  VAL VAL GLU THR PRO LEU LEU HIS PRO GLU ARG PHE VAL          
SEQRES  11 A  352  ASN LEU GLY ILE GLU PRO PRO LYS GLY VAL LEU LEU PHE          
SEQRES  12 A  352  GLY PRO PRO GLY THR GLY LYS THR LEU CYS ALA ARG ALA          
SEQRES  13 A  352  VAL ALA ASN ARG THR ASP ALA CYS PHE ILE ARG VAL ILE          
SEQRES  14 A  352  GLY SER GLU LEU VAL GLN LYS TYR VAL GLY GLU GLY ALA          
SEQRES  15 A  352  ARG MET VAL ARG GLU LEU PHE GLU MET ALA ARG THR LYS          
SEQRES  16 A  352  LYS ALA CYS LEU ILE PHE PHE ASP GLU ILE ASP ALA ILE          
SEQRES  17 A  352  GLY GLY ALA ARG PHE ASP ASP GLY ALA GLY GLY ASP ASN          
SEQRES  18 A  352  GLU VAL GLN ARG THR MET LEU GLU LEU ILE ASN GLN LEU          
SEQRES  19 A  352  ASP GLY PHE ASP PRO ARG GLY ASN ILE LYS VAL LEU MET          
SEQRES  20 A  352  ALA THR ASN ARG PRO ASP THR LEU ASP PRO ALA LEU MET          
SEQRES  21 A  352  ARG PRO GLY ARG LEU ASP ARG LYS ILE GLU PHE SER LEU          
SEQRES  22 A  352  PRO ASP LEU GLU GLY ARG THR HIS ILE PHE LYS ILE HIS          
SEQRES  23 A  352  ALA ARG SER MET SER VAL GLU ARG ASP ILE ARG PHE GLU          
SEQRES  24 A  352  LEU LEU ALA ARG LEU CYS PRO ASN SER THR GLY ALA GLU          
SEQRES  25 A  352  ILE ARG SER VAL CYS THR GLU ALA GLY MET PHE ALA ILE          
SEQRES  26 A  352  ARG ALA ARG ARG LYS ILE ALA THR GLU LYS ASP PHE LEU          
SEQRES  27 A  352  GLU ALA VAL ASN LYS VAL ILE LYS SER TYR ALA LYS PHE          
SEQRES  28 A  352  SER                                                          
SEQRES   1 B  340  GLU GLU GLU ARG SER LYS VAL ASP ASP LEU ARG GLY THR          
SEQRES   2 B  340  PRO MET SER VAL GLY THR LEU GLU GLU ILE ILE ASP ASP          
SEQRES   3 B  340  ASN HIS ALA ILE VAL SER THR SER VAL GLY SER GLU HIS          
SEQRES   4 B  340  TYR VAL SER ILE LEU SER PHE VAL ASP LYS ASP LEU LEU          
SEQRES   5 B  340  GLU PRO GLY CYS SER VAL LEU LEU ASN HIS LYS VAL HIS          
SEQRES   6 B  340  ALA VAL ILE GLY VAL LEU MET ASP ASP THR ASP PRO LEU          
SEQRES   7 B  340  VAL THR VAL MET LYS VAL GLU LYS ALA PRO GLN GLU THR          
SEQRES   8 B  340  TYR ALA ASP ILE GLY GLY LEU ASP ASN GLN ILE GLN GLU          
SEQRES   9 B  340  ILE LYS GLU SER VAL GLU LEU PRO LEU THR HIS PRO GLU          
SEQRES  10 B  340  TYR TYR GLU GLU MET GLY ILE LYS PRO PRO LYS GLY VAL          
SEQRES  11 B  340  ILE LEU TYR GLY PRO PRO GLY THR GLY LYS THR LEU LEU          
SEQRES  12 B  340  ALA LYS ALA VAL ALA ASN GLN THR SER ALA THR PHE LEU          
SEQRES  13 B  340  ARG VAL VAL GLY SER GLU LEU ILE GLN LYS TYR LEU GLY          
SEQRES  14 B  340  ASP GLY PRO LYS LEU VAL ARG GLU LEU PHE ARG VAL ALA          
SEQRES  15 B  340  GLU GLU HIS ALA PRO SER ILE VAL PHE ILE ASP GLU ILE          
SEQRES  16 B  340  ASP ALA ILE GLY THR LYS ARG TYR ASP SER ASN SER GLY          
SEQRES  17 B  340  GLY GLU ARG GLU ILE GLN ARG THR MET LEU GLU LEU LEU          
SEQRES  18 B  340  ASN GLN LEU ASP GLY PHE ASP SER ARG GLY ASP VAL LYS          
SEQRES  19 B  340  VAL ILE MET ALA THR ASN ARG ILE GLU THR LEU ASP PRO          
SEQRES  20 B  340  ALA LEU ILE ARG PRO GLY ARG ILE ASP ARG LYS ILE GLU          
SEQRES  21 B  340  PHE PRO LEU PRO ASP GLU LYS THR LYS LYS ARG ILE PHE          
SEQRES  22 B  340  GLN ILE HIS THR SER ARG MET THR LEU ALA ASP ASP VAL          
SEQRES  23 B  340  THR LEU ASP ASP LEU ILE MET ALA LYS ASP ASP LEU SER          
SEQRES  24 B  340  GLY ALA ASP ILE LYS ALA ILE CYS THR GLU ALA GLY LEU          
SEQRES  25 B  340  MET ALA LEU ARG GLU ARG ARG MET LYS VAL THR ASN GLU          
SEQRES  26 B  340  ASP PHE LYS LYS SER LYS GLU ASN VAL LEU TYR LYS LYS          
SEQRES  27 B  340  GLN GLU                                                      
SEQRES   1 C  385  LEU GLU GLU GLY LYS ALA GLY SER GLY LEU ARG GLN TYR          
SEQRES   2 C  385  TYR LEU SER LYS ILE GLU GLU LEU GLN LEU ILE VAL ASN          
SEQRES   3 C  385  ASP LYS SER GLN ASN LEU ARG ARG LEU GLN ALA GLN ARG          
SEQRES   4 C  385  ASN GLU LEU ASN ALA LYS VAL ARG LEU LEU ARG GLU GLU          
SEQRES   5 C  385  LEU GLN LEU LEU GLN GLU GLN GLY SER TYR VAL GLY GLU          
SEQRES   6 C  385  VAL VAL ARG ALA MET ASP LYS LYS LYS VAL LEU VAL LYS          
SEQRES   7 C  385  VAL HIS PRO GLU GLY LYS PHE VAL VAL ASP VAL ASP LYS          
SEQRES   8 C  385  ASN ILE ASP ILE ASN ASP VAL THR PRO ASN CYS ARG VAL          
SEQRES   9 C  385  ALA LEU ARG ASN ASP SER TYR THR LEU HIS LYS ILE LEU          
SEQRES  10 C  385  PRO ASN LYS VAL ASP PRO LEU VAL SER LEU MET MET VAL          
SEQRES  11 C  385  GLU LYS VAL PRO ASP SER THR TYR GLU MET ILE GLY GLY          
SEQRES  12 C  385  LEU ASP LYS GLN ILE LYS GLU ILE LYS GLU VAL ILE GLU          
SEQRES  13 C  385  LEU PRO VAL LYS HIS PRO GLU LEU PHE GLU ALA LEU GLY          
SEQRES  14 C  385  ILE ALA GLN PRO LYS GLY VAL LEU LEU TYR GLY PRO PRO          
SEQRES  15 C  385  GLY THR GLY LYS THR LEU LEU ALA ARG ALA VAL ALA HIS          
SEQRES  16 C  385  HIS THR ASP CYS THR PHE ILE ARG VAL SER GLY SER GLU          
SEQRES  17 C  385  LEU VAL GLN LYS PHE ILE GLY GLU GLY ALA ARG MET VAL          
SEQRES  18 C  385  ARG GLU LEU PHE VAL MET ALA ARG GLU HIS ALA PRO SER          
SEQRES  19 C  385  ILE ILE PHE MET ASP GLU ILE ASP SER ILE GLY SER SER          
SEQRES  20 C  385  ARG LEU GLU GLY GLY SER GLY GLY ASP SER GLU VAL GLN          
SEQRES  21 C  385  ARG THR MET LEU GLU LEU LEU ASN GLN LEU ASP GLY PHE          
SEQRES  22 C  385  GLU ALA THR LYS ASN ILE LYS VAL ILE MET ALA THR ASN          
SEQRES  23 C  385  ARG ILE ASP ILE LEU ASP SER ALA LEU LEU ARG PRO GLY          
SEQRES  24 C  385  ARG ILE ASP ARG LYS ILE GLU PHE PRO PRO PRO ASN GLU          
SEQRES  25 C  385  GLU ALA ARG LEU ASP ILE LEU LYS ILE HIS SER ARG LYS          
SEQRES  26 C  385  MET ASN LEU THR ARG GLY ILE ASN LEU ARG LYS ILE ALA          
SEQRES  27 C  385  GLU LEU MET PRO GLY ALA SER GLY ALA GLU VAL LYS GLY          
SEQRES  28 C  385  VAL CYS THR GLU ALA GLY MET TYR ALA LEU ARG GLU ARG          
SEQRES  29 C  385  ARG VAL HIS VAL THR GLN GLU ASP PHE GLU MET ALA VAL          
SEQRES  30 C  385  ALA LYS VAL MET GLN LYS ASP SER                              
SEQRES   1 D  368  ASP LEU TYR SER ARG TYR LYS LYS LEU GLN GLN GLU LEU          
SEQRES   2 D  368  GLU PHE LEU GLU VAL GLN GLU GLU TYR ILE LYS ASP GLU          
SEQRES   3 D  368  GLN LYS ASN LEU LYS LYS GLU PHE LEU HIS ALA GLN GLU          
SEQRES   4 D  368  GLU VAL LYS ARG ILE GLN SER ILE PRO LEU VAL ILE GLY          
SEQRES   5 D  368  GLN PHE LEU GLU ALA VAL ASP GLN ASN THR ALA ILE VAL          
SEQRES   6 D  368  GLY SER THR THR GLY SER ASN TYR TYR VAL ARG ILE LEU          
SEQRES   7 D  368  SER THR ILE ASP ARG GLU LEU LEU LYS PRO ASN ALA SER          
SEQRES   8 D  368  VAL ALA LEU HIS LYS HIS SER ASN ALA LEU VAL ASP VAL          
SEQRES   9 D  368  LEU PRO PRO GLU ALA ASP SER SER ILE MET MET LEU THR          
SEQRES  10 D  368  SER ASP GLN LYS PRO ASP VAL MET TYR ALA ASP ILE GLY          
SEQRES  11 D  368  GLY MET ASP ILE GLN LYS GLN GLU VAL ARG GLU ALA VAL          
SEQRES  12 D  368  GLU LEU PRO LEU THR HIS PHE GLU LEU TYR LYS GLN ILE          
SEQRES  13 D  368  GLY ILE ASP PRO PRO ARG GLY VAL LEU MET TYR GLY PRO          
SEQRES  14 D  368  PRO GLY CYS GLY LYS THR MET LEU ALA LYS ALA VAL ALA          
SEQRES  15 D  368  HIS HIS THR THR ALA ALA PHE ILE ARG VAL VAL GLY SER          
SEQRES  16 D  368  GLU PHE VAL GLN LYS TYR LEU GLY GLU GLY PRO ARG MET          
SEQRES  17 D  368  VAL ARG ASP VAL PHE ARG LEU ALA LYS GLU ASN ALA PRO          
SEQRES  18 D  368  ALA ILE ILE PHE ILE ASP GLU ILE ASP ALA ILE ALA THR          
SEQRES  19 D  368  LYS ARG PHE ASP ALA GLN THR GLY ALA ASP ARG GLU VAL          
SEQRES  20 D  368  GLN ARG ILE LEU LEU GLU LEU LEU ASN GLN MET ASP GLY          
SEQRES  21 D  368  PHE ASP GLN ASN VAL ASN VAL LYS VAL ILE MET ALA THR          
SEQRES  22 D  368  ASN ARG ALA ASP THR LEU ASP PRO ALA LEU LEU ARG PRO          
SEQRES  23 D  368  GLY ARG LEU ASP ARG LYS ILE GLU PHE PRO LEU PRO ASP          
SEQRES  24 D  368  ARG ARG GLN LYS ARG LEU ILE PHE SER THR ILE THR SER          
SEQRES  25 D  368  LYS MET ASN LEU SER GLU GLU VAL ASP LEU GLU ASP TYR          
SEQRES  26 D  368  VAL ALA ARG PRO ASP LYS ILE SER GLY ALA ASP ILE ASN          
SEQRES  27 D  368  SER ILE CYS GLN GLU SER GLY MET LEU ALA VAL ARG GLU          
SEQRES  28 D  368  ASN ARG TYR ILE VAL LEU ALA LYS ASP PHE GLU LYS ALA          
SEQRES  29 D  368  TYR LYS THR VAL                                              
SEQRES   1 E  379  ASP TYR ARG LYS LYS LEU LEU GLU HIS LYS GLU ILE ASP          
SEQRES   2 E  379  GLY ARG LEU LYS GLU LEU ARG GLU GLN LEU LYS GLU LEU          
SEQRES   3 E  379  THR LYS GLN TYR GLU LYS SER GLU ASN ASP LEU LYS ALA          
SEQRES   4 E  379  LEU GLN SER VAL GLY GLN ILE VAL GLY GLU VAL LEU LYS          
SEQRES   5 E  379  GLN LEU THR GLU GLU LYS PHE ILE VAL LYS ALA THR ASN          
SEQRES   6 E  379  GLY PRO ARG TYR VAL VAL GLY CYS ARG ARG GLN LEU ASP          
SEQRES   7 E  379  LYS SER LYS LEU LYS PRO GLY THR ARG VAL ALA LEU ASP          
SEQRES   8 E  379  MET THR THR LEU THR ILE MET ARG TYR LEU PRO ARG GLU          
SEQRES   9 E  379  VAL ASP PRO LEU VAL TYR ASN MET SER HIS GLU ASP PRO          
SEQRES  10 E  379  GLY ASN VAL SER TYR SER GLU ILE GLY GLY LEU SER GLU          
SEQRES  11 E  379  GLN ILE ARG GLU LEU ARG GLU VAL ILE GLU LEU PRO LEU          
SEQRES  12 E  379  THR ASN PRO GLU LEU PHE GLN ARG VAL GLY ILE ILE PRO          
SEQRES  13 E  379  PRO LYS GLY CYS LEU LEU TYR GLY PRO PRO GLY THR GLY          
SEQRES  14 E  379  LYS THR LEU LEU ALA ARG ALA VAL ALA SER GLN LEU ASP          
SEQRES  15 E  379  CYS ASN PHE LEU LYS VAL VAL SER SER SER ILE VAL ASP          
SEQRES  16 E  379  LYS TYR ILE GLY GLU SER ALA ARG LEU ILE ARG GLU MET          
SEQRES  17 E  379  PHE ASN TYR ALA ARG ASP HIS GLN PRO CYS ILE ILE PHE          
SEQRES  18 E  379  MET ASP GLU ILE ASP ALA ILE GLY GLY ARG ARG PHE SER          
SEQRES  19 E  379  GLU GLY THR SER ALA ASP ARG GLU ILE GLN ARG THR LEU          
SEQRES  20 E  379  MET GLU LEU LEU ASN GLN MET ASP GLY PHE ASP THR LEU          
SEQRES  21 E  379  HIS ARG VAL LYS MET ILE MET ALA THR ASN ARG PRO ASP          
SEQRES  22 E  379  THR LEU ASP PRO ALA LEU LEU ARG PRO GLY ARG LEU ASP          
SEQRES  23 E  379  ARG LYS ILE HIS ILE ASP LEU PRO ASN GLU GLN ALA ARG          
SEQRES  24 E  379  LEU ASP ILE LEU LYS ILE HIS ALA GLY PRO ILE THR LYS          
SEQRES  25 E  379  HIS GLY GLU ILE ASP TYR GLU ALA ILE VAL LYS LEU SER          
SEQRES  26 E  379  ASP GLY PHE ASN GLY ALA ASP LEU ARG ASN VAL CYS THR          
SEQRES  27 E  379  GLU ALA GLY MET PHE ALA ILE ARG ALA ASP HIS ASP PHE          
SEQRES  28 E  379  VAL VAL GLN GLU ASP PHE MET LYS ALA VAL ARG LYS VAL          
SEQRES  29 E  379  ALA ASP SER LYS LYS LEU GLU SER LYS LEU ASP TYR LYS          
SEQRES  30 E  379  PRO VAL                                                      
SEQRES   1 F  380  LYS ILE MET LYS SER GLU VAL LEU ARG VAL THR HIS GLU          
SEQRES   2 F  380  LEU GLN ALA MET LYS ASP LYS ILE LYS GLU ASN SER GLU          
SEQRES   3 F  380  LYS ILE LYS VAL ASN LYS THR LEU PRO TYR LEU VAL SER          
SEQRES   4 F  380  ASN VAL ILE GLU LEU LEU ASP VAL ASP PRO ASN ASP GLN          
SEQRES   5 F  380  GLU GLU ASP GLY ALA ASN ILE ASP LEU ASP SER GLN ARG          
SEQRES   6 F  380  LYS GLY LYS CYS ALA VAL ILE LYS THR SER THR ARG GLN          
SEQRES   7 F  380  THR TYR PHE LEU PRO VAL ILE GLY LEU VAL ASP ALA GLU          
SEQRES   8 F  380  LYS LEU LYS PRO GLY ASP LEU VAL GLY VAL ASN LYS ASP          
SEQRES   9 F  380  SER TYR LEU ILE LEU GLU THR LEU PRO THR GLU TYR ASP          
SEQRES  10 F  380  SER ARG VAL LYS ALA MET GLU VAL ASP GLU ARG PRO THR          
SEQRES  11 F  380  GLU GLN TYR SER ASP ILE GLY GLY LEU ASP LYS GLN ILE          
SEQRES  12 F  380  GLN GLU LEU VAL GLU ALA ILE VAL LEU PRO MET ASN HIS          
SEQRES  13 F  380  LYS GLU LYS PHE GLU ASN LEU GLY ILE GLN PRO PRO LYS          
SEQRES  14 F  380  GLY VAL LEU MET TYR GLY PRO PRO GLY THR GLY LYS THR          
SEQRES  15 F  380  LEU LEU ALA ARG ALA CYS ALA ALA GLN THR LYS ALA THR          
SEQRES  16 F  380  PHE LEU LYS LEU ALA GLY PRO GLN LEU VAL GLN MET PHE          
SEQRES  17 F  380  ILE GLY ASP GLY ALA LYS LEU VAL ARG ASP ALA PHE ALA          
SEQRES  18 F  380  LEU ALA LYS GLU LYS ALA PRO SER ILE ILE PHE ILE ASP          
SEQRES  19 F  380  GLU LEU ASP ALA ILE GLY THR LYS ARG PHE ASP SER GLU          
SEQRES  20 F  380  LYS ALA GLY ASP ARG GLU VAL GLN ARG THR MET LEU GLU          
SEQRES  21 F  380  LEU LEU ASN GLN LEU ASP GLY PHE GLN PRO ASN THR GLN          
SEQRES  22 F  380  VAL LYS VAL ILE ALA ALA THR ASN ARG VAL ASP ILE LEU          
SEQRES  23 F  380  ASP PRO ALA LEU LEU ARG SER GLY ARG LEU ASP ARG LYS          
SEQRES  24 F  380  ILE GLU PHE PRO MET PRO ASN GLU GLU ALA ARG ALA ARG          
SEQRES  25 F  380  ILE MET GLN ILE HIS SER ARG LYS MET ASN VAL SER PRO          
SEQRES  26 F  380  ASP VAL ASN TYR GLU GLU LEU ALA ARG CYS THR ASP ASP          
SEQRES  27 F  380  PHE ASN GLY ALA GLN CYS LYS ALA VAL CYS VAL GLU ALA          
SEQRES  28 F  380  GLY MET ILE ALA LEU ARG ARG GLY ALA THR GLU LEU THR          
SEQRES  29 F  380  HIS GLU ASP TYR MET GLU GLY ILE LEU GLU VAL GLN ALA          
SEQRES  30 F  380  LYS LYS LYS                                                  
SEQRES   1 U  841  GLU TYR VAL GLU THR ILE ILE ALA LYS CYS ILE ASP HIS          
SEQRES   2 U  841  TYR THR LYS GLN CYS VAL GLU ASN ALA ASP LEU PRO GLU          
SEQRES   3 U  841  GLY GLU LYS LYS PRO ILE ASP GLN ARG LEU GLU GLY ILE          
SEQRES   4 U  841  VAL ASN LYS MET PHE GLN ARG CYS LEU ASP ASP HIS LYS          
SEQRES   5 U  841  TYR LYS GLN ALA ILE GLY ILE ALA LEU GLU THR ARG ARG          
SEQRES   6 U  841  LEU ASP VAL PHE GLU LYS THR ILE LEU GLU SER ASN ASP          
SEQRES   7 U  841  VAL PRO GLY MET LEU ALA TYR SER LEU LYS LEU CYS MET          
SEQRES   8 U  841  SER LEU MET GLN ASN LYS GLN PHE ARG ASN LYS VAL LEU          
SEQRES   9 U  841  ARG VAL LEU VAL LYS ILE TYR MET ASN LEU GLU LYS PRO          
SEQRES  10 U  841  ASP PHE ILE ASN VAL CYS GLN CYS LEU ILE PHE LEU ASP          
SEQRES  11 U  841  ASP PRO GLN ALA VAL SER ASP ILE LEU GLU LYS LEU VAL          
SEQRES  12 U  841  LYS GLU ASP ASN LEU LEU MET ALA TYR GLN ILE CYS PHE          
SEQRES  13 U  841  ASP LEU TYR GLU SER ALA SER GLN GLN PHE LEU SER SER          
SEQRES  14 U  841  VAL ILE GLN ASN LEU ARG THR VAL GLY THR PRO ILE ALA          
SEQRES  15 U  841  SER VAL PRO GLY SER THR ASN THR GLY THR VAL PRO GLY          
SEQRES  16 U  841  SER GLU LYS ASP SER ASP SER MET GLU THR GLU GLU LYS          
SEQRES  17 U  841  THR SER SER ALA PHE VAL GLY LYS THR PRO GLU ALA SER          
SEQRES  18 U  841  PRO GLU PRO LYS ASP GLN THR LEU LYS MET ILE LYS ILE          
SEQRES  19 U  841  LEU SER GLY GLU MET ALA ILE GLU LEU HIS LEU GLN PHE          
SEQRES  20 U  841  LEU ILE ARG ASN ASN ASN THR ASP LEU MET ILE LEU LYS          
SEQRES  21 U  841  ASN THR LYS ASP ALA VAL ARG ASN SER VAL CYS HIS THR          
SEQRES  22 U  841  ALA THR VAL ILE ALA ASN SER PHE MET HIS CYS GLY THR          
SEQRES  23 U  841  THR SER ASP GLN PHE LEU ARG ASP ASN LEU GLU TRP LEU          
SEQRES  24 U  841  ALA ARG ALA THR ASN TRP ALA LYS PHE THR ALA THR ALA          
SEQRES  25 U  841  SER LEU GLY VAL ILE HIS LYS GLY HIS GLU LYS GLU ALA          
SEQRES  26 U  841  LEU GLN LEU MET ALA THR TYR LEU PRO LYS ASP THR SER          
SEQRES  27 U  841  PRO GLY SER ALA TYR GLN GLU GLY GLY GLY LEU TYR ALA          
SEQRES  28 U  841  LEU GLY LEU ILE HIS ALA ASN HIS GLY GLY ASP ILE ILE          
SEQRES  29 U  841  ASP TYR LEU LEU ASN GLN LEU LYS ASN ALA SER ASN ASP          
SEQRES  30 U  841  ILE VAL ARG HIS GLY GLY SER LEU GLY LEU GLY LEU ALA          
SEQRES  31 U  841  ALA MET GLY THR ALA ARG GLN ASP VAL TYR ASP LEU LEU          
SEQRES  32 U  841  LYS THR ASN LEU TYR GLN ASP ASP ALA VAL THR GLY GLU          
SEQRES  33 U  841  ALA ALA GLY LEU ALA LEU GLY LEU VAL MET LEU GLY SER          
SEQRES  34 U  841  LYS ASN ALA GLN ALA ILE GLU ASP MET VAL GLY TYR ALA          
SEQRES  35 U  841  GLN GLU THR GLN HIS GLU LYS ILE LEU ARG GLY LEU ALA          
SEQRES  36 U  841  VAL GLY ILE ALA LEU VAL MET TYR GLY ARG MET GLU GLU          
SEQRES  37 U  841  ALA ASP ALA LEU ILE GLU SER LEU CYS ARG ASP LYS ASP          
SEQRES  38 U  841  PRO ILE LEU ARG ARG SER GLY MET TYR THR VAL ALA MET          
SEQRES  39 U  841  ALA TYR CYS GLY SER GLY ASN ASN LYS ALA ILE ARG ARG          
SEQRES  40 U  841  LEU LEU HIS VAL ALA VAL SER ASP VAL ASN ASP ASP VAL          
SEQRES  41 U  841  ARG ARG ALA ALA VAL GLU SER LEU GLY PHE ILE LEU PHE          
SEQRES  42 U  841  ARG THR PRO GLU GLN CYS PRO SER VAL VAL SER LEU LEU          
SEQRES  43 U  841  SER GLU SER TYR ASN PRO HIS VAL ARG TYR GLY ALA ALA          
SEQRES  44 U  841  MET ALA LEU GLY ILE CYS CYS ALA GLY THR GLY ASN LYS          
SEQRES  45 U  841  GLU ALA ILE ASN LEU LEU GLU PRO MET THR ASN ASP PRO          
SEQRES  46 U  841  VAL ASN TYR VAL ARG GLN GLY ALA LEU ILE ALA SER ALA          
SEQRES  47 U  841  LEU ILE MET ILE GLN GLN THR GLU ILE THR CYS PRO LYS          
SEQRES  48 U  841  VAL ASN GLN PHE ARG GLN LEU TYR SER LYS VAL ILE ASN          
SEQRES  49 U  841  ASP LYS HIS ASP ASP VAL MET ALA LYS PHE GLY ALA ILE          
SEQRES  50 U  841  LEU ALA GLN GLY ILE LEU ASP ALA GLY GLY HIS ASN VAL          
SEQRES  51 U  841  THR ILE SER LEU GLN SER ARG THR GLY HIS THR HIS MET          
SEQRES  52 U  841  PRO SER VAL VAL GLY VAL LEU VAL PHE THR GLN PHE TRP          
SEQRES  53 U  841  PHE TRP PHE PRO LEU SER HIS PHE LEU SER LEU ALA TYR          
SEQRES  54 U  841  THR PRO THR CYS VAL ILE GLY LEU ASN LYS ASP LEU LYS          
SEQRES  55 U  841  MET PRO LYS VAL GLN TYR LYS SER ASN CYS LYS PRO SER          
SEQRES  56 U  841  THR PHE ALA TYR PRO ALA PRO LEU GLU VAL PRO LYS GLU          
SEQRES  57 U  841  LYS GLU LYS GLU LYS VAL SER THR ALA VAL LEU SER ILE          
SEQRES  58 U  841  THR ALA LYS ALA LYS LYS LYS GLU LYS GLU LYS GLU LYS          
SEQRES  59 U  841  LYS GLU GLU GLU LYS MET GLU VAL ASP GLU ALA GLU LYS          
SEQRES  60 U  841  LYS GLU GLU LYS GLU LYS LYS LYS GLU PRO GLU PRO ASN          
SEQRES  61 U  841  PHE GLN LEU LEU ASP ASN PRO ALA ARG VAL MET PRO ALA          
SEQRES  62 U  841  GLN LEU LYS VAL LEU THR MET PRO GLU THR CYS ARG TYR          
SEQRES  63 U  841  GLN PRO PHE LYS PRO LEU SER ILE GLY GLY ILE ILE ILE          
SEQRES  64 U  841  LEU LYS ASP THR SER GLU ASP ILE GLU GLU LEU VAL GLU          
SEQRES  65 U  841  PRO VAL ALA ALA HIS GLY PRO LYS ILE                          
SEQRES   1 V  183  GLY PHE LYS GLN THR VAL HIS LYS LEU LEU ILE VAL VAL          
SEQRES   2 V  183  GLU LEU LEU LEU GLY GLU ILE PRO ASP ARG LEU GLN PHE          
SEQRES   3 V  183  ARG GLN PRO SER LEU LYS ARG SER LEU MET PRO TYR PHE          
SEQRES   4 V  183  LEU LEU THR GLN ALA VAL ARG THR GLY ASN LEU ALA LYS          
SEQRES   5 V  183  PHE ASN GLN VAL LEU ASP GLN PHE GLY GLU LYS PHE GLN          
SEQRES   6 V  183  ALA ASP GLY THR TYR THR LEU ILE ILE ARG LEU ARG HIS          
SEQRES   7 V  183  ASN VAL ILE LYS THR GLY VAL ARG MET ILE SER LEU SER          
SEQRES   8 V  183  TYR SER ARG ILE SER LEU ALA ASP ILE ALA GLN LYS LEU          
SEQRES   9 V  183  GLN LEU ASP SER PRO GLU ASP ALA GLU PHE ILE VAL ALA          
SEQRES  10 V  183  LYS ALA ILE ARG ASP GLY VAL ILE GLU ALA SER ILE ASN          
SEQRES  11 V  183  HIS GLU LYS GLY TYR VAL GLN SER LYS GLU MET ILE ASP          
SEQRES  12 V  183  ILE TYR SER THR ARG GLU PRO GLN LEU ALA PHE HIS GLN          
SEQRES  13 V  183  ARG ILE SER PHE CYS LEU ASP ILE HIS ASN MET SER VAL          
SEQRES  14 V  183  LYS ALA MET ARG PHE PRO PRO LYS SER TYR ASN LYS ASP          
SEQRES  15 V  183  LEU                                                          
SEQRES   1 W  456  MET ALA ASP GLY GLY SER GLU ARG ALA ASP GLY ARG ILE          
SEQRES   2 W  456  VAL LYS MET GLU VAL ASP TYR SER ALA THR VAL ASP GLN          
SEQRES   3 W  456  ARG LEU PRO GLU CYS ALA LYS LEU ALA LYS GLU GLY ARG          
SEQRES   4 W  456  LEU GLN GLU VAL ILE GLU THR LEU LEU SER LEU GLU LYS          
SEQRES   5 W  456  GLN THR ARG THR ALA SER ASP MET VAL SER THR SER ARG          
SEQRES   6 W  456  ILE LEU VAL ALA VAL VAL LYS MET CYS TYR GLU ALA LYS          
SEQRES   7 W  456  GLU TRP ASP LEU LEU ASN GLU ASN ILE MET LEU LEU SER          
SEQRES   8 W  456  LYS ARG ARG SER GLN LEU LYS GLN ALA VAL ALA LYS MET          
SEQRES   9 W  456  VAL GLN GLN CYS CYS THR TYR VAL GLU GLU ILE THR ASP          
SEQRES  10 W  456  LEU PRO ILE LYS LEU ARG LEU ILE ASP THR LEU ARG MET          
SEQRES  11 W  456  VAL THR GLU GLY LYS ILE TYR VAL GLU ILE GLU ARG ALA          
SEQRES  12 W  456  ARG LEU THR LYS THR LEU ALA THR ILE LYS GLU GLN ASN          
SEQRES  13 W  456  GLY ASP VAL LYS GLU ALA ALA SER ILE LEU GLN GLU LEU          
SEQRES  14 W  456  GLN VAL GLU THR TYR GLY SER MET GLU LYS LYS GLU ARG          
SEQRES  15 W  456  VAL GLU PHE ILE LEU GLU GLN MET ARG LEU CYS LEU ALA          
SEQRES  16 W  456  VAL LYS ASP TYR ILE ARG THR GLN ILE ILE SER LYS LYS          
SEQRES  17 W  456  ILE ASN THR LYS PHE PHE GLN GLU GLU ASN THR GLU LYS          
SEQRES  18 W  456  LEU LYS LEU LYS TYR TYR ASN LEU MET ILE GLN LEU ASP          
SEQRES  19 W  456  GLN HIS GLU GLY SER TYR LEU SER ILE CYS LYS HIS TYR          
SEQRES  20 W  456  ARG ALA ILE TYR ASP THR PRO CYS ILE GLN ALA GLU SER          
SEQRES  21 W  456  GLU LYS TRP GLN GLN ALA LEU LYS SER VAL VAL LEU TYR          
SEQRES  22 W  456  VAL ILE LEU ALA PRO PHE ASP ASN GLU GLN SER ASP LEU          
SEQRES  23 W  456  VAL HIS ARG ILE SER GLY ASP LYS LYS LEU GLU GLU ILE          
SEQRES  24 W  456  PRO LYS TYR LYS ASP LEU LEU LYS LEU PHE THR THR MET          
SEQRES  25 W  456  GLU LEU MET ARG TRP SER THR LEU VAL GLU ASP TYR GLY          
SEQRES  26 W  456  MET GLU LEU ARG LYS GLY SER LEU GLU SER PRO ALA THR          
SEQRES  27 W  456  ASP VAL PHE GLY SER THR GLU GLU GLY GLU LYS ARG TRP          
SEQRES  28 W  456  LYS ASP LEU LYS ASN ARG VAL VAL GLU HIS ASN ILE ARG          
SEQRES  29 W  456  ILE MET ALA LYS TYR TYR THR ARG ILE THR MET LYS ARG          
SEQRES  30 W  456  MET ALA GLN LEU LEU ASP LEU SER VAL ASP GLU SER GLU          
SEQRES  31 W  456  ALA PHE LEU SER ASN LEU VAL VAL ASN LYS THR ILE PHE          
SEQRES  32 W  456  ALA LYS VAL ASP ARG LEU ALA GLY ILE ILE ASN PHE GLN          
SEQRES  33 W  456  ARG PRO LYS ASP PRO ASN ASN LEU LEU ASN ASP TRP SER          
SEQRES  34 W  456  GLN LYS LEU ASN SER LEU MET SER LEU VAL ASN LYS THR          
SEQRES  35 W  456  THR HIS LEU ILE ALA LYS GLU GLU MET ILE HIS ASN LEU          
SEQRES  36 W  456  GLN                                                          
SEQRES   1 X  385  ASN ASP GLU GLU ALA VAL GLN VAL LYS GLU GLN SER ILE          
SEQRES   2 X  385  LEU GLU LEU GLY SER LEU LEU ALA LYS THR GLY GLN ALA          
SEQRES   3 X  385  ALA GLU LEU GLY GLY LEU LEU LYS TYR VAL ARG PRO PHE          
SEQRES   4 X  385  LEU ASN SER ILE SER LYS ALA LYS ALA ALA ARG LEU VAL          
SEQRES   5 X  385  ARG SER LEU LEU ASP LEU PHE LEU ASP MET GLU ALA ALA          
SEQRES   6 X  385  THR GLY GLN GLU VAL GLU LEU CYS LEU GLU CYS ILE GLU          
SEQRES   7 X  385  TRP ALA LYS SER GLU LYS ARG THR PHE LEU ARG GLN ALA          
SEQRES   8 X  385  LEU GLU ALA ARG LEU VAL SER LEU TYR PHE ASP THR LYS          
SEQRES   9 X  385  ARG TYR GLN GLU ALA LEU HIS LEU GLY SER GLN LEU LEU          
SEQRES  10 X  385  ARG GLU LEU LYS LYS MET ASP ASP LYS ALA LEU LEU VAL          
SEQRES  11 X  385  GLU VAL GLN LEU LEU GLU SER LYS THR TYR HIS ALA LEU          
SEQRES  12 X  385  SER ASN LEU PRO LYS ALA ARG ALA ALA LEU THR SER ALA          
SEQRES  13 X  385  ARG THR THR ALA ASN ALA ILE TYR CYS PRO PRO LYS LEU          
SEQRES  14 X  385  GLN ALA THR LEU ASP MET GLN SER GLY ILE ILE HIS ALA          
SEQRES  15 X  385  ALA GLU GLU LYS ASP TRP LYS THR ALA TYR SER TYR PHE          
SEQRES  16 X  385  TYR GLU ALA PHE GLU GLY TYR ASP SER ILE ASP SER PRO          
SEQRES  17 X  385  LYS ALA ILE THR SER LEU LYS TYR MET LEU LEU CYS LYS          
SEQRES  18 X  385  ILE MET LEU ASN THR PRO GLU ASP VAL GLN ALA LEU VAL          
SEQRES  19 X  385  SER GLY LYS LEU ALA LEU ARG TYR ALA GLY ARG GLN THR          
SEQRES  20 X  385  GLU ALA LEU LYS CYS VAL ALA GLN ALA SER LYS ASN ARG          
SEQRES  21 X  385  SER LEU ALA ASP PHE GLU LYS ALA LEU THR ASP TYR ARG          
SEQRES  22 X  385  ALA GLU LEU ARG ASP ASP PRO ILE ILE SER THR HIS LEU          
SEQRES  23 X  385  ALA LYS LEU TYR ASP ASN LEU LEU GLU GLN ASN LEU ILE          
SEQRES  24 X  385  ARG VAL ILE GLU PRO PHE SER ARG VAL GLN ILE GLU HIS          
SEQRES  25 X  385  ILE SER SER LEU ILE LYS LEU SER LYS ALA ASP VAL GLU          
SEQRES  26 X  385  ARG LYS LEU SER GLN MET ILE LEU ASP LYS LYS PHE HIS          
SEQRES  27 X  385  GLY ILE LEU ASP GLN GLY GLU GLY VAL LEU ILE ILE PHE          
SEQRES  28 X  385  ASP GLU PRO PRO VAL ASP LYS THR TYR GLU ALA ALA LEU          
SEQRES  29 X  385  GLU THR ILE GLN ASN MET SER LYS VAL VAL ASP SER LEU          
SEQRES  30 X  385  TYR ASN LYS ALA LYS LYS LEU THR                              
SEQRES   1 Y  378  PRO LYS ASN PRO ASP LEU ARG ILE ALA GLN LEU ARG PHE          
SEQRES   2 Y  378  LEU LEU SER LEU PRO GLU HIS ARG GLY ASP ALA ALA VAL          
SEQRES   3 Y  378  ARG ASP GLU LEU MET ALA ALA VAL ARG ASP ASN ASN MET          
SEQRES   4 Y  378  ALA PRO TYR TYR GLU ALA LEU CYS LYS SER LEU ASP TRP          
SEQRES   5 Y  378  GLN ILE ASP VAL ASP LEU LEU ASN LYS MET LYS LYS ALA          
SEQRES   6 Y  378  ASN GLU ASP GLU LEU LYS ARG LEU ASP GLU GLU LEU GLU          
SEQRES   7 Y  378  ASP ALA GLU LYS ASN LEU GLY GLU SER GLU ILE ARG ASP          
SEQRES   8 Y  378  ALA MET MET ALA LYS ALA GLU TYR LEU CYS ARG ILE GLY          
SEQRES   9 Y  378  ASP LYS GLU GLY ALA LEU THR ALA PHE ARG LYS THR TYR          
SEQRES  10 Y  378  ASP LYS THR VAL ALA LEU GLY HIS ARG LEU ASP ILE VAL          
SEQRES  11 Y  378  PHE TYR LEU LEU ARG ILE GLY LEU PHE TYR MET ASP ASN          
SEQRES  12 Y  378  ASP LEU ILE THR ARG ASN THR GLU LYS ALA LYS SER LEU          
SEQRES  13 Y  378  ILE GLU GLU GLY GLY ASP TRP ASP ARG ARG ASN ARG LEU          
SEQRES  14 Y  378  LYS VAL TYR GLN GLY LEU TYR CYS VAL ALA ILE ARG ASP          
SEQRES  15 Y  378  PHE LYS GLN ALA ALA GLU LEU PHE LEU ASP THR VAL SER          
SEQRES  16 Y  378  THR PHE THR SER TYR GLU LEU MET ASP TYR LYS THR PHE          
SEQRES  17 Y  378  VAL THR TYR THR VAL TYR VAL SER MET ILE ALA LEU GLU          
SEQRES  18 Y  378  ARG PRO ASP LEU ARG GLU LYS VAL ILE LYS GLY ALA GLU          
SEQRES  19 Y  378  ILE LEU GLU VAL LEU HIS SER LEU PRO ALA VAL ARG GLN          
SEQRES  20 Y  378  TYR LEU PHE SER LEU TYR GLU CYS ARG TYR SER VAL PHE          
SEQRES  21 Y  378  PHE GLN SER LEU ALA VAL VAL GLU GLN GLU MET LYS LYS          
SEQRES  22 Y  378  ASP TRP LEU PHE ALA PRO HIS TYR ARG TYR TYR VAL ARG          
SEQRES  23 Y  378  GLU MET ARG ILE HIS ALA TYR SER GLN LEU LEU GLU SER          
SEQRES  24 Y  378  TYR ARG SER LEU THR LEU GLY TYR MET ALA GLU ALA PHE          
SEQRES  25 Y  378  GLY VAL GLY VAL GLU PHE ILE ASP GLN GLU LEU SER ARG          
SEQRES  26 Y  378  PHE ILE ALA ALA GLY ARG LEU HIS CYS LYS ILE ASP LYS          
SEQRES  27 Y  378  VAL ASN GLU ILE VAL GLU THR ASN ARG PRO ASP SER LYS          
SEQRES  28 Y  378  ASN TRP GLN TYR GLN GLU THR ILE LYS LYS GLY ASP LEU          
SEQRES  29 Y  378  LEU LEU ASN ARG VAL GLN LYS LEU SER ARG VAL ILE ASN          
SEQRES  30 Y  378  MET                                                          
SEQRES   1 Z  286  ALA VAL GLN LYS VAL VAL VAL HIS PRO LEU VAL LEU LEU          
SEQRES   2 Z  286  SER VAL VAL ASP HIS PHE ASN ARG ILE GLY LYS VAL GLY          
SEQRES   3 Z  286  ASN GLN LYS ARG VAL VAL GLY VAL LEU LEU GLY SER TRP          
SEQRES   4 Z  286  GLN LYS LYS VAL LEU ASP VAL SER ASN SER PHE ALA VAL          
SEQRES   5 Z  286  PRO PHE ASP GLU ASP ASP LYS ASP ASP SER VAL TRP PHE          
SEQRES   6 Z  286  LEU ASP HIS ASP TYR LEU GLU ASN MET TYR GLY MET PHE          
SEQRES   7 Z  286  LYS LYS VAL ASN ALA ARG GLU ARG ILE VAL GLY TRP TYR          
SEQRES   8 Z  286  HIS THR GLY PRO LYS LEU HIS LYS ASN ASP ILE ALA ILE          
SEQRES   9 Z  286  ASN GLU LEU MET LYS ARG TYR CYS PRO ASN SER VAL LEU          
SEQRES  10 Z  286  VAL ILE ILE ASP VAL LYS PRO LYS ASP LEU GLY LEU PRO          
SEQRES  11 Z  286  THR GLU ALA TYR ILE SER VAL GLU GLU VAL HIS ASP ASP          
SEQRES  12 Z  286  GLY THR PRO THR SER LYS THR PHE GLU HIS VAL THR SER          
SEQRES  13 Z  286  GLU ILE GLY ALA GLU GLU ALA GLU GLU VAL GLY VAL GLU          
SEQRES  14 Z  286  HIS LEU LEU ARG ASP ILE LYS ASP THR THR VAL GLY THR          
SEQRES  15 Z  286  LEU SER GLN ARG ILE THR ASN GLN VAL HIS GLY LEU LYS          
SEQRES  16 Z  286  GLY LEU ASN SER LYS LEU LEU ASP ILE ARG SER TYR LEU          
SEQRES  17 Z  286  GLU LYS VAL ALA THR GLY LYS LEU PRO ILE ASN HIS GLN          
SEQRES  18 Z  286  ILE ILE TYR GLN LEU GLN ASP VAL PHE ASN LEU LEU PRO          
SEQRES  19 Z  286  ASP VAL SER LEU GLN GLU PHE VAL LYS ALA PHE TYR LEU          
SEQRES  20 Z  286  LYS THR ASN ASP GLN MET VAL VAL VAL TYR LEU ALA SER          
SEQRES  21 Z  286  LEU ILE ARG SER VAL VAL ALA LEU HIS ASN LEU ILE ASN          
SEQRES  22 Z  286  ASN LYS ILE ALA ASN ARG ASP ALA GLU LYS LYS GLU GLY          
SEQRES   1 a  374  ASP VAL PRO GLY PHE LEU GLN GLN SER GLN ASN SER GLY          
SEQRES   2 a  374  PRO GLY GLN PRO ALA VAL TRP HIS ARG LEU GLU GLU LEU          
SEQRES   3 a  374  TYR THR LYS LYS LEU TRP HIS GLN LEU THR LEU GLN VAL          
SEQRES   4 a  374  LEU ASP PHE VAL GLN ASP PRO CYS PHE ALA GLN GLY ASP          
SEQRES   5 a  374  GLY LEU ILE LYS LEU TYR GLU ASN PHE ILE SER GLU PHE          
SEQRES   6 a  374  GLU HIS ARG VAL ASN PRO LEU SER LEU VAL GLU ILE ILE          
SEQRES   7 a  374  LEU HIS VAL VAL ARG GLN MET THR ASP PRO ASN VAL ALA          
SEQRES   8 a  374  LEU THR PHE LEU GLU LYS THR ARG GLU LYS VAL LYS SER          
SEQRES   9 a  374  SER ASP GLU ALA VAL ILE LEU CYS LYS THR ALA ILE GLY          
SEQRES  10 a  374  ALA LEU LYS LEU ASN ILE GLY ASP LEU GLN VAL THR LYS          
SEQRES  11 a  374  GLU THR ILE GLU ASP VAL GLU GLU MET LEU ASN ASN LEU          
SEQRES  12 a  374  PRO GLY VAL THR SER VAL HIS SER ARG PHE TYR ASP LEU          
SEQRES  13 a  374  SER SER LYS TYR TYR GLN THR ILE GLY ASN HIS ALA SER          
SEQRES  14 a  374  TYR TYR LYS ASP ALA LEU ARG PHE LEU GLY CYS VAL ASP          
SEQRES  15 a  374  ILE LYS ASP LEU PRO VAL SER GLU GLN GLN GLU ARG ALA          
SEQRES  16 a  374  PHE THR LEU GLY LEU ALA GLY LEU LEU GLY GLU GLY VAL          
SEQRES  17 a  374  PHE ASN PHE GLY GLU LEU LEU MET HIS PRO VAL LEU GLU          
SEQRES  18 a  374  SER LEU ARG ASN THR ASP ARG GLN TRP LEU ILE ASP THR          
SEQRES  19 a  374  LEU TYR ALA PHE ASN SER GLY ASN VAL GLU ARG PHE GLN          
SEQRES  20 a  374  THR LEU LYS THR ALA TRP GLY GLN GLN PRO ASP LEU ALA          
SEQRES  21 a  374  ALA ASN GLU ALA GLN LEU LEU ARG LYS ILE GLN LEU LEU          
SEQRES  22 a  374  CYS LEU MET GLU MET THR PHE THR ARG PRO ALA ASN HIS          
SEQRES  23 a  374  ARG GLN LEU THR PHE GLU GLU ILE ALA LYS SER ALA LYS          
SEQRES  24 a  374  ILE THR VAL ASN GLU VAL GLU LEU LEU VAL MET LYS ALA          
SEQRES  25 a  374  LEU SER VAL GLY LEU VAL LYS GLY SER ILE ASP GLU VAL          
SEQRES  26 a  374  ASP LYS ARG VAL HIS MET THR TRP VAL GLN PRO ARG VAL          
SEQRES  27 a  374  LEU ASP LEU GLN GLN ILE LYS GLY MET LYS ASP ARG LEU          
SEQRES  28 a  374  GLU PHE TRP CYS THR ASP VAL LYS SER MET GLU MET LEU          
SEQRES  29 a  374  VAL GLU HIS GLN ALA HIS ASP ILE LEU THR                      
SEQRES   1 b  191  MET VAL LEU GLU SER THR MET VAL CYS VAL ASP ASN SER          
SEQRES   2 b  191  GLU TYR MET ARG ASN GLY ASP PHE LEU PRO THR ARG LEU          
SEQRES   3 b  191  GLN ALA GLN GLN ASP ALA VAL ASN ILE VAL CYS HIS SER          
SEQRES   4 b  191  LYS THR ARG SER ASN PRO GLU ASN ASN VAL GLY LEU ILE          
SEQRES   5 b  191  THR LEU ALA ASN ASP CYS GLU VAL LEU THR THR LEU THR          
SEQRES   6 b  191  PRO ASP THR GLY ARG ILE LEU SER LYS LEU HIS THR VAL          
SEQRES   7 b  191  GLN PRO LYS GLY LYS ILE THR PHE CYS THR GLY ILE ARG          
SEQRES   8 b  191  VAL ALA HIS LEU ALA LEU LYS HIS ARG GLN GLY LYS ASN          
SEQRES   9 b  191  HIS LYS MET ARG ILE ILE ALA PHE VAL GLY SER PRO VAL          
SEQRES  10 b  191  GLU ASP ASN GLU LYS ASP LEU VAL LYS LEU ALA LYS ARG          
SEQRES  11 b  191  LEU LYS LYS GLU LYS VAL ASN VAL ASP ILE ILE ASN PHE          
SEQRES  12 b  191  GLY GLU GLU GLU VAL ASN THR GLU LYS LEU THR ALA PHE          
SEQRES  13 b  191  VAL ASN THR LEU ASN GLY LYS ASP GLY THR GLY SER HIS          
SEQRES  14 b  191  LEU VAL THR VAL PRO PRO GLY PRO SER LEU ALA ASP ALA          
SEQRES  15 b  191  LEU ILE SER SER PRO ILE LEU ALA GLY                          
SEQRES   1 c  287  ALA VAL ASP THR ALA GLU GLN VAL TYR ILE SER SER LEU          
SEQRES   2 c  287  ALA LEU LEU LYS MET LEU LYS HIS GLY ARG ALA GLY VAL          
SEQRES   3 c  287  PRO MET GLU VAL MET GLY LEU MET LEU GLY GLU PHE VAL          
SEQRES   4 c  287  ASP ASP TYR THR VAL ARG VAL ILE ASP VAL PHE ALA MET          
SEQRES   5 c  287  PRO GLN SER GLY THR GLY VAL SER VAL GLU ALA VAL ASP          
SEQRES   6 c  287  PRO VAL PHE GLN ALA LYS MET LEU ASP MET LEU LYS GLN          
SEQRES   7 c  287  THR GLY ARG PRO GLU MET VAL VAL GLY TRP TYR HIS SER          
SEQRES   8 c  287  HIS PRO GLY PHE GLY CYS TRP LEU SER GLY VAL ASP ILE          
SEQRES   9 c  287  ASN THR GLN GLN SER PHE GLU ALA LEU SER GLU ARG ALA          
SEQRES  10 c  287  VAL ALA VAL VAL VAL ASP PRO ILE GLN SER VAL LYS GLY          
SEQRES  11 c  287  LYS VAL VAL ILE ASP ALA PHE ARG LEU ILE ASN ALA ASN          
SEQRES  12 c  287  MET MET VAL LEU GLY HIS GLU PRO ARG GLN THR THR SER          
SEQRES  13 c  287  ASN LEU GLY HIS LEU ASN LYS PRO SER ILE GLN ALA LEU          
SEQRES  14 c  287  ILE HIS GLY LEU ASN ARG HIS TYR TYR SER ILE THR ILE          
SEQRES  15 c  287  ASN TYR ARG LYS ASN GLU LEU GLU GLN LYS MET LEU LEU          
SEQRES  16 c  287  ASN LEU HIS LYS LYS SER TRP MET GLU GLY LEU THR LEU          
SEQRES  17 c  287  GLN ASP TYR SER GLU HIS CYS LYS HIS ASN GLU SER VAL          
SEQRES  18 c  287  VAL LYS GLU MET LEU GLU LEU ALA LYS ASN TYR ASN LYS          
SEQRES  19 c  287  ALA VAL GLU GLU GLU ASP LYS MET THR PRO GLU GLN LEU          
SEQRES  20 c  287  ALA ILE LYS ASN VAL GLY LYS GLN ASP PRO LYS ARG HIS          
SEQRES  21 c  287  LEU GLU GLU HIS VAL ASP VAL LEU MET THR SER ASN ILE          
SEQRES  22 c  287  VAL GLN CYS LEU ALA ALA MET LEU ASP THR VAL VAL PHE          
SEQRES  23 c  287  LYS                                                          
SEQRES   1 d  136  LEU PRO ALA LYS ASP ILE GLN THR ASN VAL TYR ILE LYS          
SEQRES   2 d  136  HIS PRO VAL SER LEU GLU GLN TYR LEU MET GLU GLY SER          
SEQRES   3 d  136  TYR ASN LYS VAL PHE LEU ALA LYS GLY ASN ILE PRO ALA          
SEQRES   4 d  136  GLU SER TYR THR PHE PHE ILE ASP ILE LEU LEU ASP THR          
SEQRES   5 d  136  ILE ARG ASP GLU ILE ALA GLY CYS ILE GLU LYS ALA TYR          
SEQRES   6 d  136  GLU LYS ILE LEU PHE THR GLU ALA THR ARG ILE LEU PHE          
SEQRES   7 d  136  PHE ASN THR PRO LYS LYS MET THR ASP TYR ALA LYS LYS          
SEQRES   8 d  136  ARG GLY TRP VAL LEU GLY PRO ASN ASN TYR TYR SER PHE          
SEQRES   9 d  136  ALA SER GLN GLN GLN LYS PRO GLU ASP THR THR ILE PRO          
SEQRES  10 d  136  SER THR GLU LEU ALA LYS GLN VAL ILE GLU TYR ALA ARG          
SEQRES  11 d  136  GLN LEU GLU MET ILE VAL                                      
SEQRES   1 e   70  MET SER GLU LYS LYS GLN PRO VAL ASP LEU GLY LEU LEU          
SEQRES   2 e   70  GLU GLU ASP ASP GLU PHE GLU GLU PHE PRO ALA GLU ASP          
SEQRES   3 e   70  TRP ALA GLY LEU ASP GLU ASP GLU ASP ALA HIS VAL TRP          
SEQRES   4 e   70  GLU ASP ASN TRP ASP ASP ASP ASN VAL GLU ASP ASP PHE          
SEQRES   5 e   70  SER ASN GLN LEU ARG ALA GLU LEU GLU LYS HIS GLY TYR          
SEQRES   6 e   70  LYS MET GLU THR SER                                          
SEQRES   1 f  848  ARG ASP LYS ALA PRO VAL GLN PRO GLN GLN SER PRO ALA          
SEQRES   2 f  848  ALA ALA PRO GLY GLY THR ASP GLU LYS PRO SER GLY LYS          
SEQRES   3 f  848  GLU ARG ARG ASP ALA GLY ASP LYS ASP LYS GLU GLN GLU          
SEQRES   4 f  848  LEU SER GLU GLU ASP LYS GLN LEU GLN ASP GLU LEU GLU          
SEQRES   5 f  848  MET LEU VAL GLU ARG LEU GLY GLU LYS ASP THR SER LEU          
SEQRES   6 f  848  TYR ARG PRO ALA LEU GLU GLU LEU ARG ARG GLN ILE ARG          
SEQRES   7 f  848  SER SER THR THR SER MET THR SER VAL PRO LYS PRO LEU          
SEQRES   8 f  848  LYS PHE LEU ARG PRO HIS TYR GLY LYS LEU LYS GLU ILE          
SEQRES   9 f  848  TYR GLU ASN MET ALA PRO GLY GLU ASN LYS ARG PHE ALA          
SEQRES  10 f  848  ALA ASP ILE ILE SER VAL LEU ALA MET THR MET SER GLY          
SEQRES  11 f  848  GLU ARG GLU CYS LEU LYS TYR ARG LEU VAL GLY SER GLN          
SEQRES  12 f  848  GLU GLU LEU ALA SER TRP GLY HIS GLU TYR VAL ARG HIS          
SEQRES  13 f  848  LEU ALA GLY GLU VAL ALA LYS GLU TRP GLN GLU LEU ASP          
SEQRES  14 f  848  ASP ALA GLU LYS VAL GLN ARG GLU PRO LEU LEU THR LEU          
SEQRES  15 f  848  VAL LYS GLU ILE VAL PRO TYR ASN MET ALA HIS ASN ALA          
SEQRES  16 f  848  GLU HIS GLU ALA CYS ASP LEU LEU MET GLU ILE GLU GLN          
SEQRES  17 f  848  VAL ASP MET LEU GLU LYS ASP ILE ASP GLU ASN ALA TYR          
SEQRES  18 f  848  ALA LYS VAL CYS LEU TYR LEU THR SER CYS VAL ASN TYR          
SEQRES  19 f  848  VAL PRO GLU PRO GLU ASN SER ALA LEU LEU ARG CYS ALA          
SEQRES  20 f  848  LEU GLY VAL PHE ARG LYS PHE SER ARG PHE PRO GLU ALA          
SEQRES  21 f  848  LEU ARG LEU ALA LEU MET LEU ASN ASP MET GLU LEU VAL          
SEQRES  22 f  848  GLU ASP ILE PHE THR SER CYS LYS ASP VAL VAL VAL GLN          
SEQRES  23 f  848  LYS GLN MET ALA PHE MET LEU GLY ARG HIS GLY VAL PHE          
SEQRES  24 f  848  LEU GLU LEU SER GLU ASP VAL GLU GLU TYR GLU ASP LEU          
SEQRES  25 f  848  THR GLU ILE MET SER ASN VAL GLN LEU ASN SER ASN PHE          
SEQRES  26 f  848  LEU ALA LEU ALA ARG GLU LEU ASP ILE MET GLU PRO LYS          
SEQRES  27 f  848  VAL PRO ASP ASP ILE TYR LYS THR HIS LEU GLU ASN ASN          
SEQRES  28 f  848  ARG PHE GLY GLY SER GLY SER GLN VAL ASP SER ALA ARG          
SEQRES  29 f  848  MET ASN LEU ALA SER SER PHE VAL ASN GLY PHE VAL ASN          
SEQRES  30 f  848  ALA ALA PHE GLY GLN ASP LYS LEU LEU THR ASP ASP GLY          
SEQRES  31 f  848  ASN LYS TRP LEU TYR LYS ASN LYS ASP HIS GLY MET LEU          
SEQRES  32 f  848  SER ALA ALA ALA SER LEU GLY MET ILE LEU LEU TRP ASP          
SEQRES  33 f  848  VAL ASP GLY GLY LEU THR GLN ILE ASP LYS TYR LEU TYR          
SEQRES  34 f  848  SER SER GLU ASP TYR ILE LYS SER GLY ALA LEU LEU ALA          
SEQRES  35 f  848  CYS GLY ILE VAL ASN SER GLY VAL ARG ASN GLU CYS ASP          
SEQRES  36 f  848  PRO ALA LEU ALA LEU LEU SER ASP TYR VAL LEU HIS ASN          
SEQRES  37 f  848  SER ASN THR MET ARG LEU GLY SER ILE PHE GLY LEU GLY          
SEQRES  38 f  848  LEU ALA TYR ALA GLY SER ASN ARG GLU ASP VAL LEU THR          
SEQRES  39 f  848  LEU LEU LEU PRO VAL MET GLY ASP SER LYS SER SER MET          
SEQRES  40 f  848  GLU VAL ALA GLY VAL THR ALA LEU ALA CYS GLY MET ILE          
SEQRES  41 f  848  ALA VAL GLY SER CYS ASN GLY ASP VAL THR SER THR ILE          
SEQRES  42 f  848  LEU GLN THR ILE MET GLU LYS SER GLU THR GLU LEU LYS          
SEQRES  43 f  848  ASP THR TYR ALA ARG TRP LEU PRO LEU GLY LEU GLY LEU          
SEQRES  44 f  848  ASN HIS LEU GLY LYS GLY GLU ALA ILE GLU ALA ILE LEU          
SEQRES  45 f  848  ALA ALA LEU GLU VAL VAL SER GLU PRO PHE ARG SER PHE          
SEQRES  46 f  848  ALA ASN THR LEU VAL ASP VAL CYS ALA TYR ALA GLY SER          
SEQRES  47 f  848  GLY ASN VAL LEU LYS VAL GLN GLN LEU LEU HIS ILE CYS          
SEQRES  48 f  848  SER GLU HIS PHE ASP SER LYS GLU LYS GLU GLU ASP LYS          
SEQRES  49 f  848  ASP LYS LYS GLU LYS LYS ASP LYS ASP LYS LYS GLU ALA          
SEQRES  50 f  848  PRO ALA ASP MET GLY ALA HIS GLN GLY VAL ALA VAL LEU          
SEQRES  51 f  848  GLY ILE ALA LEU ILE ALA MET GLY GLU GLU ILE GLY ALA          
SEQRES  52 f  848  GLU MET ALA LEU ARG THR PHE GLY HIS LEU LEU ARG TYR          
SEQRES  53 f  848  GLY GLU PRO THR LEU ARG ARG ALA VAL PRO LEU ALA LEU          
SEQRES  54 f  848  ALA LEU ILE SER VAL SER ASN PRO ARG LEU ASN ILE LEU          
SEQRES  55 f  848  ASP THR LEU SER LYS PHE SER HIS ASP ALA ASP PRO GLU          
SEQRES  56 f  848  VAL SER TYR ASN SER ILE PHE ALA MET GLY MET VAL GLY          
SEQRES  57 f  848  SER GLY THR ASN ASN ALA ARG LEU ALA ALA MET LEU ARG          
SEQRES  58 f  848  GLN LEU ALA GLN TYR HIS ALA LYS ASP PRO ASN ASN LEU          
SEQRES  59 f  848  PHE MET VAL ARG LEU ALA GLN GLY LEU THR HIS LEU GLY          
SEQRES  60 f  848  LYS GLY THR LEU THR LEU CYS PRO TYR HIS SER ASP ARG          
SEQRES  61 f  848  GLN LEU MET SER GLN VAL ALA VAL ALA GLY LEU LEU THR          
SEQRES  62 f  848  VAL LEU VAL SER PHE LEU ASP VAL ARG ASN ILE ILE LEU          
SEQRES  63 f  848  GLY LYS SER HIS TYR VAL LEU TYR GLY LEU VAL ALA ALA          
SEQRES  64 f  848  MET GLN PRO ARG MET LEU VAL THR PHE ASP GLU GLU LEU          
SEQRES  65 f  848  ARG PRO LEU PRO VAL SER VAL ARG VAL GLY GLN ALA VAL          
SEQRES  66 f  848  ASP VAL VAL                                                  
HET     ZN  c 400       1                                                       
HETNAM      ZN ZINC ION                                                         
FORMUL  20   ZN    ZN 2+                                                        
HELIX    1 AA1 LEU G    8  GLY G   17  1                                  10    
HELIX    2 AA2 LYS G   18  ASP G   29  1                                  12    
HELIX    3 AA3 LYS G   30  ARG G   35  1                                   6    
HELIX    4 AA4 THR G   42  GLY G   51  1                                  10    
HELIX    5 AA5 HIS G   52  GLY G   63  1                                  12    
HELIX    6 AA6 SER G   75  GLY G   84  1                                  10    
HELIX    7 AA7 ARG G   85  GLY G   96  1                                  12    
HELIX    8 AA8 THR G  108  LYS G  116  1                                   9    
HELIX    9 AA9 ARG G  118  GLY G  129  1                                  12    
HELIX   10 AB1 THR G  141  GLY G  150  1                                  10    
HELIX   11 AB2 ASN G  151  TYR G  160  1                                  10    
HELIX   12 AB3 THR G  174  GLU G  182  1                                   9    
HELIX   13 AB4 ARG G  184  GLN G  194  1                                  11    
HELIX   14 AB5 THR G  207  ALA G  212  1                                   6    
HELIX   15 AB6 GLY G  215  GLY G  226  1                                  12    
HELIX   16 AB7 PRO A   74  ALA A   82  1                                   9    
HELIX   17 AB8 LYS A   84  SER A   89  1                                   6    
HELIX   18 AB9 ALA A  130  ILE A  134  5                                   5    
HELIX   19 AC1 THR A  160  GLN A  165  1                                   6    
HELIX   20 AC2 THR A  173  VAL A  177  5                                   5    
HELIX   21 AC3 CYS A  180  GLU A  192  1                                  13    
HELIX   22 AC4 GLU A  192  HIS A  197  1                                   6    
HELIX   23 AC5 HIS A  197  LEU A  204  1                                   8    
HELIX   24 AC6 LYS A  222  ASN A  231  1                                  10    
HELIX   25 AC7 GLY A  251  LYS A  267  1                                  17    
HELIX   26 AC8 ILE A  277  ILE A  280  5                                   4    
HELIX   27 AC9 ASP A  292  ASP A  307  1                                  16    
HELIX   28 AD1 THR A  326  ARG A  333  1                                   8    
HELIX   29 AD2 PRO A  334  ARG A  336  5                                   3    
HELIX   30 AD3 ASP A  347  HIS A  358  1                                  12    
HELIX   31 AD4 ALA A  359  SER A  361  5                                   3    
HELIX   32 AD5 ARG A  369  LEU A  376  1                                   8    
HELIX   33 AD6 THR A  381  ALA A  399  1                                  19    
HELIX   34 AD7 THR A  405  SER A  424  1                                  20    
HELIX   35 AD8 LYS B   98  LEU B  102  5                                   5    
HELIX   36 AD9 ASP B  168  MET B  174  5                                   7    
HELIX   37 AE1 LEU B  190  GLU B  202  1                                  13    
HELIX   38 AE2 HIS B  207  TYR B  211  5                                   5    
HELIX   39 AE3 GLY B  231  VAL B  239  1                                   9    
HELIX   40 AE4 SER B  253  LYS B  258  1                                   6    
HELIX   41 AE5 PRO B  264  GLU B  276  1                                  13    
HELIX   42 AE6 GLU B  302  GLY B  318  1                                  17    
HELIX   43 AE7 ASP B  338  ILE B  342  5                                   5    
HELIX   44 AE8 GLU B  358  THR B  369  1                                  12    
HELIX   45 AE9 ASP B  382  LYS B  387  1                                   6    
HELIX   46 AF1 SER B  391  ARG B  408  1                                  18    
HELIX   47 AF2 THR B  415  LYS B  430  1                                  16    
HELIX   48 AF3 ALA C   16  GLU C   68  1                                  53    
HELIX   49 AF4 ASP C  155  LYS C  162  1                                   8    
HELIX   50 AF5 GLU C  166  HIS C  171  1                                   6    
HELIX   51 AF6 PRO C  172  GLU C  176  5                                   5    
HELIX   52 AF7 THR C  197  ASP C  208  1                                  12    
HELIX   53 AF8 ARG C  232  HIS C  241  1                                  10    
HELIX   54 AF9 GLU C  260  LEU C  280  1                                  21    
HELIX   55 AG1 ILE C  298  ARG C  307  1                                  10    
HELIX   56 AG2 GLU C  322  HIS C  332  1                                  11    
HELIX   57 AG3 ASN C  343  LEU C  350  1                                   8    
HELIX   58 AG4 GLY C  356  GLU C  365  1                                  10    
HELIX   59 AG5 ALA C  366  ARG C  374  1                                   9    
HELIX   60 AG6 THR C  379  ASP C  394  1                                  16    
HELIX   61 AG7 TYR D   41  VAL D   56  1                                  16    
HELIX   62 AG8 VAL D   56  ARG D   81  1                                  26    
HELIX   63 AG9 ASP D  120  LEU D  124  5                                   5    
HELIX   64 AH1 ASP D  171  THR D  186  1                                  16    
HELIX   65 AH2 THR D  213  THR D  223  1                                  11    
HELIX   66 AH3 SER D  233  PHE D  235  5                                   3    
HELIX   67 AH4 GLY D  241  ALA D  258  1                                  18    
HELIX   68 AH5 ILE D  267  ALA D  271  5                                   5    
HELIX   69 AH6 THR D  279  PHE D  299  1                                  21    
HELIX   70 AH7 ASP D  337  SER D  350  1                                  14    
HELIX   71 AH8 GLU D  361  ILE D  370  1                                  10    
HELIX   72 AH9 ASP D  374  ALA D  386  1                                  13    
HELIX   73 AI1 LEU D  395  VAL D  406  1                                  12    
HELIX   74 AI2 TYR E   12  GLU E   28  1                                  17    
HELIX   75 AI3 ARG E   30  GLU E   35  1                                   6    
HELIX   76 AI4 GLU E   35  LEU E   50  1                                  16    
HELIX   77 AI5 VAL E  115  MET E  122  1                                   8    
HELIX   78 AI6 VAL E  130  GLU E  134  5                                   5    
HELIX   79 AI7 GLY E  179  LEU E  191  1                                  13    
HELIX   80 AI8 SER E  211  HIS E  225  1                                  15    
HELIX   81 AI9 THR E  247  ASP E  265  1                                  19    
HELIX   82 AJ1 ASN E  305  ALA E  317  1                                  13    
HELIX   83 AJ2 TYR E  328  SER E  335  1                                   8    
HELIX   84 AJ3 ASN E  339  ARG E  356  1                                  18    
HELIX   85 AJ4 GLN E  364  GLU E  381  1                                  18    
HELIX   86 AJ5 ILE F   54  SER F   57  5                                   4    
HELIX   87 AJ6 GLU F   58  SER F   77  1                                  20    
HELIX   88 AJ7 GLU F   78  LYS F   84  1                                   7    
HELIX   89 AJ8 ASP F  169  ALA F  174  1                                   6    
HELIX   90 AJ9 GLN F  184  ILE F  188  5                                   5    
HELIX   91 AK1 LEU F  191  HIS F  208  1                                  18    
HELIX   92 AK2 GLU F  210  GLY F  216  1                                   7    
HELIX   93 AK3 THR F  234  LYS F  245  1                                  12    
HELIX   94 AK4 PRO F  254  VAL F  257  5                                   4    
HELIX   95 AK5 GLY F  262  LYS F  278  1                                  17    
HELIX   96 AK6 ALA F  301  LEU F  317  1                                  17    
HELIX   97 AK7 ASN F  358  SER F  370  1                                  13    
HELIX   98 AK8 TYR F  381  THR F  388  1                                   8    
HELIX   99 AK9 ASN F  392  ARG F  410  1                                  19    
HELIX  100 AL1 GLU F  418  GLN F  428  1                                  11    
HELIX  101 AL2 TYR U   96  ASN U  115  1                                  20    
HELIX  102 AL3 ASP U  127  LEU U  142  1                                  16    
HELIX  103 AL4 ASP U  143  LYS U  148  5                                   6    
HELIX  104 AL5 GLN U  149  THR U  157  1                                   9    
HELIX  105 AL6 ASP U  172  MET U  185  1                                  14    
HELIX  106 AL7 PHE U  193  VAL U  202  1                                  10    
HELIX  107 AL8 ASP U  212  ILE U  221  1                                  10    
HELIX  108 AL9 ASP U  225  ALA U  228  5                                   4    
HELIX  109 AM1 VAL U  229  ASP U  240  1                                  12    
HELIX  110 AM2 ASN U  241  SER U  255  1                                  15    
HELIX  111 AM3 GLN U  258  VAL U  271  1                                  14    
HELIX  112 AM4 PRO U  318  LEU U  329  1                                  12    
HELIX  113 AM5 GLY U  331  LEU U  342  1                                  12    
HELIX  114 AM6 ASP U  349  VAL U  360  1                                  12    
HELIX  115 AM7 CYS U  365  HIS U  377  1                                  13    
HELIX  116 AM8 SER U  382  LEU U  386  5                                   5    
HELIX  117 AM9 ASN U  398  HIS U  412  1                                  15    
HELIX  118 AN1 LYS U  417  THR U  425  1                                   9    
HELIX  119 AN2 ALA U  436  HIS U  450  1                                  15    
HELIX  120 AN3 ILE U  457  LYS U  466  1                                  10    
HELIX  121 AN4 ASP U  471  ALA U  485  1                                  15    
HELIX  122 AN5 ARG U  490  TYR U  502  1                                  13    
HELIX  123 AN6 ASP U  505  MET U  520  1                                  16    
HELIX  124 AN7 ASN U  525  GLN U  537  1                                  13    
HELIX  125 AN8 GLU U  542  VAL U  555  1                                  14    
HELIX  126 AN9 ALA U  563  CYS U  571  1                                   9    
HELIX  127 AO1 ASP U  575  TYR U  590  1                                  16    
HELIX  128 AO2 LYS U  597  ASP U  609  1                                  13    
HELIX  129 AO3 ASN U  611  ALA U  617  1                                   7    
HELIX  130 AO4 ALA U  618  LEU U  626  1                                   9    
HELIX  131 AO5 GLU U  631  GLU U  642  1                                  12    
HELIX  132 AO6 ASN U  645  CYS U  660  1                                  16    
HELIX  133 AO7 ASN U  665  ASN U  670  1                                   6    
HELIX  134 AO8 LEU U  671  THR U  676  1                                   6    
HELIX  135 AO9 VAL U  680  LEU U  693  1                                  14    
HELIX  136 AP1 LYS U  705  SER U  714  1                                  10    
HELIX  137 AP2 ASP U  723  ASP U  738  1                                  16    
HELIX  138 AP3 ALA U  739  HIS U  742  5                                   4    
HELIX  139 AP4 HIS U  756  GLN U  768  1                                  13    
HELIX  140 AP5 TRP U  772  LEU U  781  5                                  10    
HELIX  141 AP6 PRO U  808  ALA U  812  5                                   5    
HELIX  142 AP7 MET U  885  LYS U  890  5                                   6    
HELIX  143 AP8 PHE V  324  LEU V  337  1                                  14    
HELIX  144 AP9 LEU V  338  GLY V  340  5                                   3    
HELIX  145 AQ1 SER V  352  GLY V  370  1                                  19    
HELIX  146 AQ2 ASN V  371  GLY V  383  1                                  13    
HELIX  147 AQ3 TYR V  392  LEU V  412  1                                  21    
HELIX  148 AQ4 ALA V  420  LEU V  426  1                                   7    
HELIX  149 AQ5 SER V  430  ARG V  443  1                                  14    
HELIX  150 AQ6 GLU V  471  LYS V  503  1                                  33    
HELIX  151 AQ7 ALA W    2  MET W   16  1                                  15    
HELIX  152 AQ8 SER W   21  GLU W   37  1                                  17    
HELIX  153 AQ9 ILE W   44  SER W   49  1                                   6    
HELIX  154 AR1 LEU W   50  THR W   63  1                                  14    
HELIX  155 AR2 ALA W   69  GLU W   79  1                                  11    
HELIX  156 AR3 ASP W   81  ILE W   87  1                                   7    
HELIX  157 AR4 SER W   95  TYR W  111  1                                  17    
HELIX  158 AR5 THR W  116  LYS W  135  1                                  20    
HELIX  159 AR6 ILE W  140  GLY W  157  1                                  18    
HELIX  160 AR7 GLU W  161  GLU W  172  1                                  12    
HELIX  161 AR8 LYS W  179  ILE W  186  1                                   8    
HELIX  162 AR9 LEU W  187  GLN W  189  5                                   3    
HELIX  163 AS1 LEU W  192  LYS W  197  1                                   6    
HELIX  164 AS2 ASP W  198  ILE W  205  1                                   8    
HELIX  165 AS3 LYS W  207  ASN W  210  1                                   4    
HELIX  166 AS4 LEU W  222  LEU W  229  1                                   8    
HELIX  167 AS5 GLN W  232  GLY W  238  1                                   7    
HELIX  168 AS6 TYR W  240  CYS W  244  5                                   5    
HELIX  169 AS7 ALA W  249  TYR W  251  5                                   3    
HELIX  170 AS8 ASP W  252  GLN W  257  1                                   6    
HELIX  171 AS9 GLU W  261  VAL W  270  1                                  10    
HELIX  172 AT1 VAL W  271  LEU W  276  1                                   6    
HELIX  173 AT2 ASN W  281  SER W  291  1                                  11    
HELIX  174 AT3 ASP W  293  GLU W  298  1                                   6    
HELIX  175 AT4 LYS W  301  LEU W  308  1                                   8    
HELIX  176 AT5 TRP W  317  LYS W  330  1                                  14    
HELIX  177 AT6 PRO W  336  PHE W  341  1                                   6    
HELIX  178 AT7 GLU W  345  ALA W  367  1                                  23    
HELIX  179 AT8 THR W  374  LEU W  382  1                                   9    
HELIX  180 AT9 SER W  385  VAL W  397  1                                  13    
HELIX  181 AU1 LEU W  424  ILE W  452  1                                  29    
HELIX  182 AU2 HIS W  453  GLN W  456  5                                   4    
HELIX  183 AU3 ASP X   39  THR X   60  1                                  22    
HELIX  184 AU4 ALA X   63  VAL X   73  1                                  11    
HELIX  185 AU5 VAL X   73  ASN X   78  1                                   6    
HELIX  186 AU6 SER X   81  ASP X   98  1                                  18    
HELIX  187 AU7 ALA X  102  GLU X  120  1                                  19    
HELIX  188 AU8 ARG X  122  LYS X  141  1                                  20    
HELIX  189 AU9 ARG X  142  LYS X  158  1                                  17    
HELIX  190 AV1 ASP X  162  LEU X  180  1                                  19    
HELIX  191 AV2 ASN X  182  ALA X  197  1                                  16    
HELIX  192 AV3 PRO X  203  GLU X  222  1                                  20    
HELIX  193 AV4 ASP X  224  TYR X  239  1                                  16    
HELIX  194 AV5 ASP X  243  MET X  260  1                                  18    
HELIX  195 AV6 PRO X  264  GLY X  273  1                                  10    
HELIX  196 AV7 GLY X  273  ARG X  278  1                                   6    
HELIX  197 AV8 GLY X  281  ARG X  297  1                                  17    
HELIX  198 AV9 LEU X  299  TYR X  309  1                                  11    
HELIX  199 AW1 ILE X  319  ILE X  339  1                                  21    
HELIX  200 AW2 GLN X  346  SER X  352  1                                   7    
HELIX  201 AW3 SER X  357  ASP X  371  1                                  15    
HELIX  202 AW4 VAL X  393  THR X  422  1                                  30    
HELIX  203 AW5 PRO Y   15  ALA Y   20  1                                   6    
HELIX  204 AW6 LEU Y   22  LEU Y   28  1                                   7    
HELIX  205 AW7 ASP Y   34  ALA Y   43  1                                  10    
HELIX  206 AW8 ALA Y   44  ARG Y   46  5                                   3    
HELIX  207 AW9 ASN Y   49  ALA Y   56  1                                   8    
HELIX  208 AX1 LEU Y   57  SER Y   60  5                                   4    
HELIX  209 AX2 ILE Y   65  GLU Y   92  1                                  28    
HELIX  210 AX3 GLU Y   97  GLY Y  115  1                                  19    
HELIX  211 AX4 GLU Y  118  LYS Y  130  1                                  13    
HELIX  212 AX5 ALA Y  133  MET Y  152  1                                  20    
HELIX  213 AX6 ASP Y  155  SER Y  166  1                                  12    
HELIX  214 AX7 ASP Y  175  ILE Y  191  1                                  17    
HELIX  215 AX8 GLN Y  196  THR Y  204  5                                   9    
HELIX  216 AX9 ASP Y  215  ALA Y  230  1                                  16    
HELIX  217 AY1 GLU Y  232  VAL Y  240  1                                   9    
HELIX  218 AY2 ALA Y  244  LEU Y  250  1                                   7    
HELIX  219 AY3 LEU Y  253  CYS Y  266  1                                  14    
HELIX  220 AY4 ARG Y  267  PHE Y  272  1                                   6    
HELIX  221 AY5 SER Y  274  LYS Y  283  1                                  10    
HELIX  222 AY6 HIS Y  291  SER Y  310  1                                  20    
HELIX  223 AY7 LEU Y  316  GLY Y  324  1                                   9    
HELIX  224 AY8 GLY Y  326  ALA Y  340  1                                  15    
HELIX  225 AY9 ASN Y  363  GLU Y  368  1                                   6    
HELIX  226 AZ1 THR Y  369  ILE Y  387  1                                  19    
HELIX  227 AZ2 HIS Z   12  PHE Z   23  1                                  12    
HELIX  228 AZ3 HIS Z   72  ASN Z   86  1                                  15    
HELIX  229 AZ4 ASN Z  104  TYR Z  115  1                                  12    
HELIX  230 AZ5 ALA Z  167  ARG Z  177  1                                  11    
HELIX  231 AZ6 THR Z  186  THR Z  217  1                                  32    
HELIX  232 AZ7 HIS Z  224  ASN Z  235  1                                  12    
HELIX  233 AZ8 PHE Z  245  LYS Z  288  1                                  44    
HELIX  234 AZ9 VAL a    4  ASN a   13  1                                  10    
HELIX  235 BA1 GLN a   18  LYS a   31  1                                  14    
HELIX  236 BA2 LEU a   33  ASP a   47  1                                  15    
HELIX  237 BA3 ASP a   54  HIS a   69  1                                  16    
HELIX  238 BA4 PRO a   73  THR a   88  1                                  16    
HELIX  239 BA5 ASP a   89  VAL a  104  1                                  16    
HELIX  240 BA6 ALA a  110  LEU a  123  1                                  14    
HELIX  241 BA7 LEU a  128  LEU a  142  1                                  15    
HELIX  242 BA8 THR a  149  GLN a  164  1                                  16    
HELIX  243 BA9 HIS a  169  CYS a  182  1                                  14    
HELIX  244 BB1 PRO a  189  GLY a  207  1                                  19    
HELIX  245 BB2 PHE a  213  HIS a  219  1                                   7    
HELIX  246 BB3 HIS a  219  ARG a  226  1                                   8    
HELIX  247 BB4 GLN a  231  GLY a  243  1                                  13    
HELIX  248 BB5 ARG a  247  TRP a  255  1                                   9    
HELIX  249 BB6 LEU a  261  GLN a  273  1                                  13    
HELIX  250 BB7 LEU a  274  ARG a  284  1                                  11    
HELIX  251 BB8 THR a  292  ALA a  300  1                                   9    
HELIX  252 BB9 GLU a  306  GLY a  318  1                                  13    
HELIX  253 BC1 LEU a  343  LEU a  375  1                                  33    
HELIX  254 BC2 SER b   13  ARG b   17  5                                   5    
HELIX  255 BC3 ARG b   25  ASN b   44  1                                  20    
HELIX  256 BC4 THR b   68  LEU b   75  1                                   8    
HELIX  257 BC5 PHE b   86  LEU b   95  1                                  10    
HELIX  258 BC6 ALA b   96  ARG b  100  5                                   5    
HELIX  259 BC7 ASN b  120  LYS b  135  1                                  16    
HELIX  260 BC8 LYS b  152  ASN b  161  1                                  10    
HELIX  261 BC9 ALA b  180  SER b  185  1                                   6    
HELIX  262 BD1 SER c   34  ALA c   47  1                                  14    
HELIX  263 BD2 ASP c   88  GLN c  101  1                                  14    
HELIX  264 BD3 SER c  123  GLU c  134  1                                  12    
HELIX  265 BD4 ASN c  164  VAL c  169  5                                   6    
HELIX  266 BD5 ASN c  180  ASN c  185  1                                   6    
HELIX  267 BD6 ASN c  210  TRP c  225  1                                  16    
HELIX  268 BD7 LEU c  231  ASN c  241  1                                  11    
HELIX  269 BD8 VAL c  244  LYS c  264  1                                  21    
HELIX  270 BD9 MET c  265  LEU c  270  1                                   6    
HELIX  271 BE1 LEU c  284  LYS c  310  1                                  27    
HELIX  272 BE2 ASN d  130  GLY d  146  1                                  17    
HELIX  273 BE3 TYR d  148  ALA d  154  1                                   7    
HELIX  274 BE4 LYS d  155  ILE d  158  5                                   4    
HELIX  275 BE5 TYR d  163  GLU d  183  1                                  21    
HELIX  276 BE6 PHE d  191  LEU d  198  1                                   8    
HELIX  277 BE7 LYS d  204  ARG d  213  1                                  10    
HELIX  278 BE8 THR d  236  GLU d  254  1                                  19    
HELIX  279 BE9 LYS e    4  PHE e   19  1                                  16    
HELIX  280 BF1 GLU e   21  TRP e   27  1                                   7    
HELIX  281 BF2 TRP e   27  ASP e   35  1                                   9    
HELIX  282 BF3 GLU e   40  SER e   53  1                                  14    
HELIX  283 BF4 GLU e   59  SER e   70  1                                  12    
HELIX  284 BF5 VAL f   11  GLN f   15  5                                   5    
HELIX  285 BF6 ALA f   19  ARG f   33  1                                  15    
HELIX  286 BF7 ARG f   34  ALA f   36  5                                   3    
HELIX  287 BF8 GLU f   44  ASP f   49  1                                   6    
HELIX  288 BF9 TYR f   71  THR f   86  1                                  16    
HELIX  289 BG1 PRO f   93  PHE f   98  1                                   6    
HELIX  290 BG2 LYS f  119  LEU f  144  1                                  26    
HELIX  291 BG3 GLY f  164  ARG f  181  1                                  18    
HELIX  292 BG4 LEU f  184  GLU f  190  1                                   7    
HELIX  293 BG5 LEU f  208  LEU f  217  1                                  10    
HELIX  294 BG6 ILE f  221  TYR f  239  1                                  19    
HELIX  295 BG7 PRO f  241  PHE f  259  1                                  19    
HELIX  296 BG8 ARG f  261  ASN f  273  1                                  13    
HELIX  297 BG9 ASP f  274  VAL f  288  1                                  15    
HELIX  298 BH1 LEU f  298  GLU f  309  1                                  12    
HELIX  299 BH2 ASP f  310  GLN f  325  1                                  16    
HELIX  300 BH3 SER f  328  ALA f  334  1                                   7    
HELIX  301 BH4 PRO f  342  THR f  351  1                                  10    
HELIX  302 BH5 ASN f  355  GLY f  360  1                                   6    
HELIX  303 BH6 ARG f  369  PHE f  380  1                                  12    
HELIX  304 BH7 LYS f  403  ILE f  417  1                                  15    
HELIX  305 BH8 ASP f  421  ASP f  430  1                                  10    
HELIX  306 BH9 GLU f  437  VAL f  451  1                                  15    
HELIX  307 BI1 CYS f  459  LEU f  466  1                                   8    
HELIX  308 BI2 ASN f  475  ALA f  488  1                                  14    
HELIX  309 BI3 VAL f  497  GLY f  506  1                                  10    
HELIX  310 BI4 SER f  511  ALA f  526  1                                  16    
HELIX  311 BI5 THR f  535  GLU f  544  1                                  10    
HELIX  312 BI6 THR f  553  LEU f  567  1                                  15    
HELIX  313 BI7 ILE f  573  VAL f  582  1                                  10    
HELIX  314 BI8 GLU f  585  ALA f  599  1                                  15    
HELIX  315 BI9 VAL f  606  ILE f  615  1                                  10    
HELIX  316 BJ1 CYS f  616  GLU f  618  5                                   3    
HELIX  317 BJ2 SER f  622  ASP f  628  1                                   7    
HELIX  318 BJ3 ASP f  630  LYS f  635  1                                   6    
HELIX  319 BJ4 ALA f  644  HIS f  649  5                                   6    
HELIX  320 BJ5 GLY f  651  MET f  662  1                                  12    
HELIX  321 BJ6 ALA f  668  LEU f  679  1                                  12    
HELIX  322 BJ7 THR f  685  ILE f  697  1                                  13    
HELIX  323 BJ8 ALA f  717  ALA f  728  1                                  12    
HELIX  324 BJ9 ARG f  740  LYS f  754  1                                  15    
HELIX  325 BK1 GLY f  774  THR f  777  5                                   4    
HELIX  326 BK2 LEU f  778  ARG f  785  1                                   8    
HELIX  327 BK3 VAL f  793  THR f  798  1                                   6    
SHEET    1 AA1 3 ILE A 101  ALA A 104  0                                        
SHEET    2 AA1 3 LYS A 110  ASN A 114 -1  O  ASN A 114   N  ILE A 101           
SHEET    3 AA1 3 LYS A 120  ASP A 124 -1  O  PHE A 121   N  ILE A 113           
SHEET    1 AA2 5 ILE A 238  VAL A 240  0                                        
SHEET    2 AA2 5 ILE A 272  ASP A 275  1  O  ASP A 275   N  VAL A 240           
SHEET    3 AA2 5 MET A 319  THR A 321  1  O  ALA A 320   N  PHE A 274           
SHEET    4 AA2 5 LEU A 213  PHE A 215  1  N  LEU A 214   O  THR A 321           
SHEET    5 AA2 5 LYS A 340  GLU A 342  1  O  ILE A 341   N  LEU A 213           
SHEET    1 AA3 3 ILE B 122  SER B 124  0                                        
SHEET    2 AA3 3 SER B 108  GLU B 114 -1  N  THR B 111   O  SER B 124           
SHEET    3 AA3 3 SER B 149  LEU B 152 -1  O  LEU B 152   N  SER B 108           
SHEET    1 AA4 4 ILE B 223  TYR B 225  0                                        
SHEET    2 AA4 4 LYS B 326  THR B 331  1  O  MET B 329   N  LEU B 224           
SHEET    3 AA4 4 ILE B 281  ASP B 285  1  N  VAL B 282   O  ILE B 328           
SHEET    4 AA4 4 LEU B 248  VAL B 251  1  N  VAL B 250   O  ASP B 285           
SHEET    1 AA5 2 THR B 373  LEU B 374  0                                        
SHEET    2 AA5 2 LYS B 413  VAL B 414  1  O  VAL B 414   N  THR B 373           
SHEET    1 AA6 5 PHE C  95  VAL C  97  0                                        
SHEET    2 AA6 5 VAL C  85  LYS C  88 -1  N  VAL C  85   O  VAL C  97           
SHEET    3 AA6 5 SER C  71  ARG C  78 -1  N  GLU C  75   O  LYS C  88           
SHEET    4 AA6 5 CYS C 112  ARG C 117 -1  O  VAL C 114   N  GLY C  74           
SHEET    5 AA6 5 LEU C 123  ILE C 126 -1  O  HIS C 124   N  ALA C 115           
SHEET    1 AA7 3 VAL C 291  MET C 293  0                                        
SHEET    2 AA7 3 GLY C 185  LEU C 187  1  N  VAL C 186   O  MET C 293           
SHEET    3 AA7 3 ARG C 313  LYS C 314  1  O  ARG C 313   N  GLY C 185           
SHEET    1 AA8 5 LEU D  87  VAL D  88  0                                        
SHEET    2 AA8 5 ARG E  78  VAL E  81 -1  O  VAL E  80   N  LEU D  87           
SHEET    3 AA8 5 PHE E  69  LYS E  72 -1  N  VAL E  71   O  TYR E  79           
SHEET    4 AA8 5 GLN E  55  VAL E  60 -1  N  GLU E  59   O  LYS E  72           
SHEET    5 AA8 5 VAL E  98  ASP E 101 -1  O  LEU E 100   N  ILE E  56           
SHEET    1 AA9 7 LEU D  87  VAL D  88  0                                        
SHEET    2 AA9 7 ARG E  78  VAL E  81 -1  O  VAL E  80   N  LEU D  87           
SHEET    3 AA9 7 PHE E  69  LYS E  72 -1  N  VAL E  71   O  TYR E  79           
SHEET    4 AA9 7 GLN E  55  VAL E  60 -1  N  GLU E  59   O  LYS E  72           
SHEET    5 AA9 7 THR F 131  LEU F 134 -1  O  PHE F 133   N  GLN E  55           
SHEET    6 AA9 7 ALA F 122  THR F 126 -1  N  ALA F 122   O  LEU F 134           
SHEET    7 AA9 7 SER F  91  GLU F  95 -1  N  ILE F  94   O  VAL F 123           
SHEET    1 AB1 3 GLN D  91  ASP D  97  0                                        
SHEET    2 AB1 3 THR D 100  GLY D 104 -1  O  GLY D 104   N  GLN D  91           
SHEET    3 AB1 3 ASN D 110  VAL D 113 -1  O  TYR D 111   N  VAL D 103           
SHEET    1 AB2 5 PHE D 227  VAL D 231  0                                        
SHEET    2 AB2 5 ALA D 260  ASP D 265  1  O  PHE D 263   N  ILE D 228           
SHEET    3 AB2 5 VAL D 305  ALA D 310  1  O  LYS D 306   N  ILE D 262           
SHEET    4 AB2 5 GLY D 201  MET D 204  1  N  VAL D 202   O  MET D 309           
SHEET    5 AB2 5 LEU D 327  LYS D 330  1  O  ARG D 329   N  LEU D 203           
SHEET    1 AB3 5 LYS E 197  VAL E 199  0                                        
SHEET    2 AB3 5 ILE E 229  ASP E 233  1  O  PHE E 231   N  VAL E 198           
SHEET    3 AB3 5 LYS E 274  ALA E 278  1  O  ALA E 278   N  MET E 232           
SHEET    4 AB3 5 GLY E 169  TYR E 173  1  N  LEU E 172   O  MET E 277           
SHEET    5 AB3 5 LEU E 295  HIS E 300  1  O  ILE E 299   N  LEU E 171           
SHEET    1 AB4 5 THR F 247  ALA F 252  0                                        
SHEET    2 AB4 5 SER F 281  ASP F 286  1  O  ILE F 282   N  THR F 247           
SHEET    3 AB4 5 VAL F 328  THR F 332  1  O  ILE F 329   N  ILE F 285           
SHEET    4 AB4 5 GLY F 222  TYR F 226  1  N  MET F 225   O  ALA F 330           
SHEET    5 AB4 5 LEU F 348  LYS F 351  1  O  ARG F 350   N  LEU F 224           
SHEET    1 AB5 2 VAL U 744  ILE U 746  0                                        
SHEET    2 AB5 2 TYR U 783  PRO U 785 -1  O  THR U 784   N  THR U 745           
SHEET    1 AB6 2 ILE U 789  GLY U 790  0                                        
SHEET    2 AB6 2 ILE U 911  ILE U 912  1  O  ILE U 912   N  ILE U 789           
SHEET    1 AB7 2 LYS U 803  SER U 804  0                                        
SHEET    2 AB7 2 LEU U 892  THR U 893 -1  O  THR U 893   N  LYS U 803           
SHEET    1 AB8 2 SER Y 313  THR Y 315  0                                        
SHEET    2 AB8 2 ILE Y 353  GLU Y 355 -1  O  VAL Y 354   N  LEU Y 314           
SHEET    1 AB9 5 LEU Z  48  VAL Z  50  0                                        
SHEET    2 AB9 5 LYS Z   8  VAL Z  11  1  N  VAL Z  10   O  LEU Z  48           
SHEET    3 AB9 5 LYS Z 153  ILE Z 162  1  O  GLU Z 161   N  VAL Z  11           
SHEET    4 AB9 5 ALA Z 137  GLU Z 142 -1  N  ALA Z 137   O  VAL Z 158           
SHEET    5 AB9 5 VAL Z 120  VAL Z 122 -1  N  LEU Z 121   O  TYR Z 138           
SHEET    1 AC1 3 SER Z  53  ALA Z  55  0                                        
SHEET    2 AC1 3 VAL Z  36  GLY Z  41 -1  N  VAL Z  38   O  PHE Z  54           
SHEET    3 AC1 3 ARG Z  90  HIS Z  96 -1  O  TYR Z  95   N  GLY Z  37           
SHEET    1 AC2 6 VAL b  60  THR b  65  0                                        
SHEET    2 AC2 6 VAL b  49  THR b  53 -1  N  LEU b  51   O  LEU b  61           
SHEET    3 AC2 6 GLU b   4  VAL b  10  1  N  THR b   6   O  GLY b  50           
SHEET    4 AC2 6 LYS b 106  VAL b 113  1  O  PHE b 112   N  CYS b   9           
SHEET    5 AC2 6 ASN b 137  ASN b 142  1  O  ILE b 141   N  VAL b 113           
SHEET    6 AC2 6 LEU b 170  THR b 172  1  O  VAL b 171   N  ILE b 140           
SHEET    1 AC3 8 TYR c 200  ILE c 203  0                                        
SHEET    2 AC3 8 ALA c 159  LEU c 162 -1  N  ARG c 161   O  TYR c 201           
SHEET    3 AC3 8 VAL c 141  VAL c 145 -1  N  ALA c 142   O  PHE c 160           
SHEET    4 AC3 8 MET c 107  SER c 114  1  N  HIS c 113   O  VAL c 145           
SHEET    5 AC3 8 MET c  54  GLU c  60 -1  N  MET c  57   O  GLY c 110           
SHEET    6 AC3 8 THR c  66  MET c  75 -1  O  ASP c  71   N  LEU c  58           
SHEET    7 AC3 8 GLN c  30  ILE c  33  1  N  TYR c  32   O  VAL c  67           
SHEET    8 AC3 8 ILE c 205  TYR c 207  1  O  ASN c 206   N  ILE c  33           
SHEET    1 AC4 2 ILE d 189  LEU d 190  0                                        
SHEET    2 AC4 2 ASN d 221  TYR d 222 -1  O  TYR d 222   N  ILE d 189           
SITE     1 AC1  1 PHE c 118                                                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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