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Database: PDB
Entry: 5VHN
LinkDB: 5VHN
Original site: 5VHN 
HEADER    HYDROLASE                               13-APR-17   5VHN              
TITLE     CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY 
TITLE    2 PARTICLE                                                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10;           
COMPND   3 CHAIN: G;                                                            
COMPND   4 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT P28,GANKYRIN,P28(GANK);   
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 7;                       
COMPND   8 CHAIN: A;                                                            
COMPND   9 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT1,PROTEASOME 26S       
COMPND  10 SUBUNIT ATPASE 2,PROTEIN MSS1;                                       
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 4;                       
COMPND  14 CHAIN: B;                                                            
COMPND  15 SYNONYM: P26S4,26S PROTEASOME AAA-ATPASE SUBUNIT RPT2,PROTEASOME 26S 
COMPND  16 SUBUNIT ATPASE 1;                                                    
COMPND  17 ENGINEERED: YES;                                                     
COMPND  18 MOL_ID: 4;                                                           
COMPND  19 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 6B;                      
COMPND  20 CHAIN: D;                                                            
COMPND  21 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT3,MB67-INTERACTING     
COMPND  22 PROTEIN,MIP224,PROTEASOME 26S SUBUNIT ATPASE 4,TAT-BINDING PROTEIN 7,
COMPND  23 TBP-7;                                                               
COMPND  24 ENGINEERED: YES;                                                     
COMPND  25 MOL_ID: 5;                                                           
COMPND  26 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 10B;                     
COMPND  27 CHAIN: E;                                                            
COMPND  28 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT4,PROTEASOME 26S       
COMPND  29 SUBUNIT ATPASE 6,PROTEASOME SUBUNIT P42;                             
COMPND  30 ENGINEERED: YES;                                                     
COMPND  31 MOL_ID: 6;                                                           
COMPND  32 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 6A;                      
COMPND  33 CHAIN: F;                                                            
COMPND  34 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT5,PROTEASOME 26S       
COMPND  35 SUBUNIT ATPASE 3,PROTEASOME SUBUNIT P50,TAT-BINDING PROTEIN 1,TBP-1; 
COMPND  36 ENGINEERED: YES;                                                     
COMPND  37 MOL_ID: 7;                                                           
COMPND  38 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 8;                       
COMPND  39 CHAIN: C;                                                            
COMPND  40 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT6,PROTEASOME 26S       
COMPND  41 SUBUNIT ATPASE 5,PROTEASOME SUBUNIT P45,THYROID HORMONE RECEPTOR-    
COMPND  42 INTERACTING PROTEIN 1,TRIP1,P45/SUG;                                 
COMPND  43 ENGINEERED: YES;                                                     
COMPND  44 MOL_ID: 8;                                                           
COMPND  45 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2;            
COMPND  46 CHAIN: f;                                                            
COMPND  47 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN1,26S PROTEASOME       
COMPND  48 REGULATORY SUBUNIT S2,26S PROTEASOME SUBUNIT P97,PROTEIN 55.11,TUMOR 
COMPND  49 NECROSIS FACTOR TYPE 1 RECEPTOR-ASSOCIATED PROTEIN 2;                
COMPND  50 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: PSMD10;                                                        
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 GENE: PSMC2, MSS1;                                                   
SOURCE  14 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  15 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  17 MOL_ID: 3;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 GENE: PSMC1;                                                         
SOURCE  22 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  23 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  24 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  25 MOL_ID: 4;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 GENE: PSMC4, MIP224, TBP7;                                           
SOURCE  30 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  31 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  32 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  33 MOL_ID: 5;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  35 ORGANISM_COMMON: HUMAN;                                              
SOURCE  36 ORGANISM_TAXID: 9606;                                                
SOURCE  37 GENE: PSMC6, SUG2;                                                   
SOURCE  38 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  39 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  40 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  41 MOL_ID: 6;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 GENE: PSMC3, TBP1;                                                   
SOURCE  46 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  47 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  48 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  49 MOL_ID: 7;                                                           
SOURCE  50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  51 ORGANISM_COMMON: HUMAN;                                              
SOURCE  52 ORGANISM_TAXID: 9606;                                                
SOURCE  53 GENE: PSMC5, SUG1;                                                   
SOURCE  54 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  55 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  56 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  57 MOL_ID: 8;                                                           
SOURCE  58 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  59 ORGANISM_COMMON: HUMAN;                                              
SOURCE  60 ORGANISM_TAXID: 9606;                                                
SOURCE  61 GENE: PSMD2, TRAP2;                                                  
SOURCE  62 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  63 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  64 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    P28, 26S PROTEASOME, REGULATORY PARTICLE, 19S, GANKYRIN, HYDROLASE    
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    Y.LU,J.WU,Y.DONG,S.CHEN,S.SUN,Y.B.MA,Q.OUYANG,D.FINLEY,M.W.KIRSCHNER, 
AUTHOR   2 Y.MAO                                                                
REVDAT   2   22-AUG-18 5VHN    1       REMARK                                   
REVDAT   1   23-AUG-17 5VHN    0                                                
JRNL        AUTH   Y.LU,J.WU,Y.DONG,S.CHEN,S.SUN,Y.B.MA,Q.OUYANG,D.FINLEY,      
JRNL        AUTH 2 M.W.KIRSCHNER,Y.MAO                                          
JRNL        TITL   CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME   
JRNL        TITL 2 REGULATORY PARTICLE.                                         
JRNL        REF    MOL. CELL                     V.  67   322 2017              
JRNL        REFN                   ISSN 1097-4164                               
JRNL        PMID   28689658                                                     
JRNL        DOI    10.1016/J.MOLCEL.2017.06.007                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    7.30 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 7.300                          
REMARK   3   NUMBER OF PARTICLES               : 21031                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5VHN COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-APR-17.                  
REMARK 100 THE DEPOSITION ID IS D_1000227420.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : PROTEASOME REGULATORY PARTICLE    
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI ARCTICA             
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 50.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, A, B, D, E, F, C, f                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     CYS G     4                                                      
REMARK 465     VAL G     5                                                      
REMARK 465     SER G     6                                                      
REMARK 465     ASN G     7                                                      
REMARK 465     ALA A   283                                                      
REMARK 465     ARG A   284                                                      
REMARK 465     PHE A   285                                                      
REMARK 465     ASP A   286                                                      
REMARK 465     ASP A   287                                                      
REMARK 465     GLY A   288                                                      
REMARK 465     ALA A   289                                                      
REMARK 465     GLY A   290                                                      
REMARK 465     THR B   167                                                      
REMARK 465     LYS B   293                                                      
REMARK 465     ARG B   294                                                      
REMARK 465     TYR B   295                                                      
REMARK 465     ASP B   296                                                      
REMARK 465     SER B   297                                                      
REMARK 465     ASN B   298                                                      
REMARK 465     SER B   299                                                      
REMARK 465     GLY B   300                                                      
REMARK 465     PRO D   145                                                      
REMARK 465     GLU D   146                                                      
REMARK 465     ALA D   147                                                      
REMARK 465     ASP D   148                                                      
REMARK 465     SER D   149                                                      
REMARK 465     SER D   150                                                      
REMARK 465     ILE D   151                                                      
REMARK 465     MET D   152                                                      
REMARK 465     MET D   153                                                      
REMARK 465     LEU D   154                                                      
REMARK 465     THR D   155                                                      
REMARK 465     SER D   156                                                      
REMARK 465     ASP D   157                                                      
REMARK 465     GLN D   158                                                      
REMARK 465     LYS D   159                                                      
REMARK 465     PRO D   160                                                      
REMARK 465     ASP D   161                                                      
REMARK 465     VAL D   162                                                      
REMARK 465     MET D   163                                                      
REMARK 465     TYR D   164                                                      
REMARK 465     ALA D   165                                                      
REMARK 465     ASP D   166                                                      
REMARK 465     ILE D   167                                                      
REMARK 465     GLY D   168                                                      
REMARK 465     GLY D   169                                                      
REMARK 465     GLU E   140                                                      
REMARK 465     GLN E   141                                                      
REMARK 465     ILE E   142                                                      
REMARK 465     ARG E   143                                                      
REMARK 465     GLU E   144                                                      
REMARK 465     LEU E   145                                                      
REMARK 465     ARG E   146                                                      
REMARK 465     GLU E   147                                                      
REMARK 465     VAL E   148                                                      
REMARK 465     ILE E   149                                                      
REMARK 465     GLU E   150                                                      
REMARK 465     LEU E   151                                                      
REMARK 465     PRO E   152                                                      
REMARK 465     LEU E   153                                                      
REMARK 465     THR E   154                                                      
REMARK 465     ASN E   155                                                      
REMARK 465     PRO E   156                                                      
REMARK 465     GLU E   157                                                      
REMARK 465     LEU E   158                                                      
REMARK 465     PHE E   159                                                      
REMARK 465     GLN E   160                                                      
REMARK 465     ARG E   161                                                      
REMARK 465     VAL E   162                                                      
REMARK 465     GLY E   163                                                      
REMARK 465     ILE E   164                                                      
REMARK 465     ILE E   165                                                      
REMARK 465     PRO E   166                                                      
REMARK 465     PRO E   167                                                      
REMARK 465     LEU E   384                                                      
REMARK 465     ASP E   385                                                      
REMARK 465     TYR E   386                                                      
REMARK 465     LYS E   387                                                      
REMARK 465     PRO E   388                                                      
REMARK 465     VAL E   389                                                      
REMARK 465     THR F   166                                                      
REMARK 465     GLU F   167                                                      
REMARK 465     ASP F   297                                                      
REMARK 465     SER F   298                                                      
REMARK 465     GLU F   299                                                      
REMARK 465     ALA F   429                                                      
REMARK 465     LYS F   430                                                      
REMARK 465     LYS F   431                                                      
REMARK 465     LYS F   432                                                      
REMARK 465     LYS C   130                                                      
REMARK 465     VAL C   131                                                      
REMARK 465     ASP C   132                                                      
REMARK 465     PRO C   133                                                      
REMARK 465     LEU C   134                                                      
REMARK 465     VAL C   135                                                      
REMARK 465     SER C   136                                                      
REMARK 465     LEU C   137                                                      
REMARK 465     MET C   138                                                      
REMARK 465     MET C   139                                                      
REMARK 465     VAL C   140                                                      
REMARK 465     GLU C   141                                                      
REMARK 465     LYS C   142                                                      
REMARK 465     VAL C   143                                                      
REMARK 465     PRO C   144                                                      
REMARK 465     ASP C   145                                                      
REMARK 465     SER C   146                                                      
REMARK 465     THR C   147                                                      
REMARK 465     TYR C   148                                                      
REMARK 465     GLU C   149                                                      
REMARK 465     MET C   150                                                      
REMARK 465     ILE C   151                                                      
REMARK 465     GLY C   152                                                      
REMARK 465     GLY C   153                                                      
REMARK 465     GLY C   216                                                      
REMARK 465     SER C   217                                                      
REMARK 465     GLU C   218                                                      
REMARK 465     LEU C   219                                                      
REMARK 465     VAL C   220                                                      
REMARK 465     GLN C   221                                                      
REMARK 465     LYS C   222                                                      
REMARK 465     PHE C   223                                                      
REMARK 465     ILE C   224                                                      
REMARK 465     GLY C   225                                                      
REMARK 465     GLU C   226                                                      
REMARK 465     GLY C   227                                                      
REMARK 465     ALA C   228                                                      
REMARK 465     ILE C   254                                                      
REMARK 465     GLY C   255                                                      
REMARK 465     SER C   256                                                      
REMARK 465     SER C   257                                                      
REMARK 465     SER C   395                                                      
REMARK 465     LEU f    56                                                      
REMARK 465     GLU f    57                                                      
REMARK 465     MET f    58                                                      
REMARK 465     LEU f    59                                                      
REMARK 465     VAL f    60                                                      
REMARK 465     GLU f    61                                                      
REMARK 465     ARG f    62                                                      
REMARK 465     LEU f    63                                                      
REMARK 465     GLY f    64                                                      
REMARK 465     GLU f    65                                                      
REMARK 465     LYS f    66                                                      
REMARK 465     ASP f    67                                                      
REMARK 465     THR f    68                                                      
REMARK 465     SER f    69                                                      
REMARK 465     GLY f   104                                                      
REMARK 465     LYS f   105                                                      
REMARK 465     LEU f   106                                                      
REMARK 465     LYS f   107                                                      
REMARK 465     GLU f   108                                                      
REMARK 465     ILE f   109                                                      
REMARK 465     TYR f   110                                                      
REMARK 465     GLU f   111                                                      
REMARK 465     ASN f   112                                                      
REMARK 465     MET f   113                                                      
REMARK 465     ALA f   114                                                      
REMARK 465     PRO f   115                                                      
REMARK 465     GLY f   116                                                      
REMARK 465     GLU f   117                                                      
REMARK 465     SER f   147                                                      
REMARK 465     GLN f   148                                                      
REMARK 465     GLU f   149                                                      
REMARK 465     GLU f   150                                                      
REMARK 465     LEU f   151                                                      
REMARK 465     ALA f   152                                                      
REMARK 465     SER f   153                                                      
REMARK 465     TRP f   154                                                      
REMARK 465     GLY f   155                                                      
REMARK 465     HIS f   156                                                      
REMARK 465     GLU f   157                                                      
REMARK 465     TYR f   158                                                      
REMARK 465     VAL f   159                                                      
REMARK 465     ARG f   160                                                      
REMARK 465     HIS f   161                                                      
REMARK 465     LEU f   162                                                      
REMARK 465     TYR f   194                                                      
REMARK 465     ASN f   195                                                      
REMARK 465     MET f   196                                                      
REMARK 465     ALA f   197                                                      
REMARK 465     HIS f   198                                                      
REMARK 465     ASN f   199                                                      
REMARK 465     ALA f   200                                                      
REMARK 465     GLU f   201                                                      
REMARK 465     HIS f   202                                                      
REMARK 465     GLU f   203                                                      
REMARK 465     ALA f   204                                                      
REMARK 465     CYS f   205                                                      
REMARK 465     ASP f   206                                                      
REMARK 465     VAL f   290                                                      
REMARK 465     GLN f   291                                                      
REMARK 465     LYS f   292                                                      
REMARK 465     GLN f   293                                                      
REMARK 465     MET f   294                                                      
REMARK 465     ALA f   295                                                      
REMARK 465     PHE f   296                                                      
REMARK 465     ALA f   383                                                      
REMARK 465     ALA f   384                                                      
REMARK 465     PHE f   385                                                      
REMARK 465     GLY f   386                                                      
REMARK 465     ALA f   490                                                      
REMARK 465     GLY f   491                                                      
REMARK 465     SER f   492                                                      
REMARK 465     SER f   700                                                      
REMARK 465     ASN f   701                                                      
REMARK 465     PRO f   702                                                      
REMARK 465     ARG f   703                                                      
REMARK 465     LEU f   704                                                      
REMARK 465     ASN f   705                                                      
REMARK 465     ILE f   706                                                      
REMARK 465     LEU f   707                                                      
REMARK 465     ASP f   708                                                      
REMARK 465     THR f   709                                                      
REMARK 465     LEU f   710                                                      
REMARK 465     SER f   711                                                      
REMARK 465     LYS f   712                                                      
REMARK 465     PHE f   713                                                      
REMARK 465     MET f   729                                                      
REMARK 465     GLY f   730                                                      
REMARK 465     MET f   731                                                      
REMARK 465     VAL f   732                                                      
REMARK 465     GLY f   733                                                      
REMARK 465     SER f   734                                                      
REMARK 465     GLY f   735                                                      
REMARK 465     THR f   736                                                      
REMARK 465     ASN f   737                                                      
REMARK 465     ASN f   738                                                      
REMARK 465     ASP f   755                                                      
REMARK 465     PRO f   756                                                      
REMARK 465     ASN f   757                                                      
REMARK 465     ASN f   758                                                      
REMARK 465     LEU f   759                                                      
REMARK 465     PHE f   760                                                      
REMARK 465     MET f   761                                                      
REMARK 465     VAL f   762                                                      
REMARK 465     ARG f   763                                                      
REMARK 465     LEU f   764                                                      
REMARK 465     ALA f   765                                                      
REMARK 465     GLN f   766                                                      
REMARK 465     GLY f   767                                                      
REMARK 465     LEU f   768                                                      
REMARK 465     THR f   769                                                      
REMARK 465     HIS f   770                                                      
REMARK 465     LEU f   771                                                      
REMARK 465     GLY f   772                                                      
REMARK 465     ASP f   805                                                      
REMARK 465     VAL f   806                                                      
REMARK 465     ARG f   807                                                      
REMARK 465     ASN f   808                                                      
REMARK 465     ILE f   809                                                      
REMARK 465     ILE f   810                                                      
REMARK 465     LEU f   811                                                      
REMARK 465     GLY f   812                                                      
REMARK 465     LYS f   813                                                      
REMARK 465     SER f   814                                                      
REMARK 465     HIS f   815                                                      
REMARK 465     TYR f   816                                                      
REMARK 465     VAL f   817                                                      
REMARK 465     LEU f   818                                                      
REMARK 465     TYR f   819                                                      
REMARK 465     GLY f   820                                                      
REMARK 465     LEU f   821                                                      
REMARK 465     VAL f   822                                                      
REMARK 465     ALA f   823                                                      
REMARK 465     ALA f   824                                                      
REMARK 465     MET f   825                                                      
REMARK 465     GLN f   826                                                      
REMARK 465     PRO f   827                                                      
REMARK 465     ARG f   828                                                      
REMARK 465     MET f   829                                                      
REMARK 465     LEU f   830                                                      
REMARK 465     VAL f   831                                                      
REMARK 465     THR f   832                                                      
REMARK 465     PHE f   833                                                      
REMARK 465     ASP f   834                                                      
REMARK 465     GLU f   835                                                      
REMARK 465     GLU f   836                                                      
REMARK 465     LEU f   837                                                      
REMARK 465     ARG f   838                                                      
REMARK 465     PRO f   839                                                      
REMARK 465     LEU f   840                                                      
REMARK 465     PRO f   841                                                      
REMARK 465     VAL f   842                                                      
REMARK 465     SER f   843                                                      
REMARK 465     VAL f   844                                                      
REMARK 465     ARG f   845                                                      
REMARK 465     VAL f   846                                                      
REMARK 465     GLY f   847                                                      
REMARK 465     GLN f   848                                                      
REMARK 465     ALA f   849                                                      
REMARK 465     VAL f   850                                                      
REMARK 465     ASP f   851                                                      
REMARK 465     VAL f   852                                                      
REMARK 465     VAL f   853                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    ASP f   347     OG1  THR f   351              2.17            
REMARK 500   O    LYS A   415     OG   SER A   419              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS A 222       -6.43     72.91                                   
REMARK 500    LYS A 267       30.68    -90.40                                   
REMARK 500    ARG A 312      146.30   -173.95                                   
REMARK 500    ARG A 339       63.65     61.33                                   
REMARK 500    LEU B 205       -7.62     72.01                                   
REMARK 500    LYS B 217       75.51     52.67                                   
REMARK 500    ASP B 348      -62.38    -92.64                                   
REMARK 500    ARG B 349      147.80   -171.92                                   
REMARK 500    ASP D 171       -3.22     67.24                                   
REMARK 500    PRO D 199       48.00    -88.60                                   
REMARK 500    LYS D 212       -2.77     67.97                                   
REMARK 500    ASP D 337       58.18    -98.35                                   
REMARK 500    ASP D 374       56.49     34.66                                   
REMARK 500    GLU D 389       -5.14     72.04                                   
REMARK 500    PRO E 176       50.17    -93.77                                   
REMARK 500    LEU E 191      -63.43   -125.37                                   
REMARK 500    ASP E 192      -12.95     67.83                                   
REMARK 500    CYS E 193       -6.33     64.27                                   
REMARK 500    ASN E 194     -168.89   -171.17                                   
REMARK 500    PRO E 282       48.89    -84.50                                   
REMARK 500    LEU E 285       32.17    -95.36                                   
REMARK 500    ASP E 286       76.54     54.32                                   
REMARK 500    PRO E 292        2.70    -69.01                                   
REMARK 500    ASP E 358       46.02     36.61                                   
REMARK 500    LYS F 245       -3.32     69.70                                   
REMARK 500    PRO F 254        3.32    -65.24                                   
REMARK 500    SER F 281     -169.94   -126.91                                   
REMARK 500    THR F 324        0.66    -64.64                                   
REMARK 500    LEU F 342       32.11    -97.33                                   
REMARK 500    ARG C 297     -164.74   -125.69                                   
REMARK 500    ASP C 299        2.13    -67.72                                   
REMARK 500    PRO C 308       45.37    -81.17                                   
REMARK 500    SER C 355     -166.80   -160.26                                   
REMARK 500    THR f  86      -63.13    -93.50                                   
REMARK 500    THR f  87      146.29   -173.16                                   
REMARK 500    ARG f 100       75.34     53.73                                   
REMARK 500    LEU f 184       -7.05     65.19                                   
REMARK 500    ARG f 261       66.70     62.13                                   
REMARK 500    LYS f 397       -2.20     69.97                                   
REMARK 500    LEU f 466       13.75     51.83                                   
REMARK 500    TYR f 469       -8.32     69.68                                   
REMARK 500    VAL f 470      -68.78   -128.86                                   
REMARK 500    LEU f 471      110.54   -166.51                                   
REMARK 500    ASN f 473       -7.42     64.81                                   
REMARK 500    ASP f 496       46.47    -91.03                                   
REMARK 500    GLU f 549       52.09    -93.93                                   
REMARK 500    LYS f 551       70.69     58.27                                   
REMARK 500    SER f 584     -159.99   -160.45                                   
REMARK 500    GLU f 585      152.41    -44.48                                   
REMARK 500    PRO f 586       -4.75    -59.42                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      53 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8679   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8674   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8675   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8676   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8677   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8678   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8672   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8680   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8681   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8682   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8683   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8684   RELATED DB: EMDB                              
REMARK 900 RELATED ID: 5VGZ   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHF   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHH   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHI   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHJ   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHM   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHO   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHP   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHQ   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHR   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHS   RELATED DB: PDB                                   
DBREF  5VHN G    4   226  UNP    O75832   PSD10_HUMAN      4    226             
DBREF  5VHN A  159   424  UNP    P35998   PRS7_HUMAN     159    424             
DBREF  5VHN B  167   432  UNP    P62191   PRS4_HUMAN     167    432             
DBREF  5VHN D  145   406  UNP    P43686   PRS6B_HUMAN    114    375             
DBREF  5VHN E  115   389  UNP    P62333   PRS10_HUMAN    115    389             
DBREF  5VHN F  166   432  UNP    P17980   PRS6A_HUMAN    166    432             
DBREF  5VHN C  130   395  UNP    P62195   PRS8_HUMAN     130    395             
DBREF  5VHN f    6   853  UNP    Q13200   PSMD2_HUMAN      6    853             
SEQRES   1 G  223  CYS VAL SER ASN LEU MET VAL CYS ASN LEU ALA TYR SER          
SEQRES   2 G  223  GLY LYS LEU GLU GLU LEU LYS GLU SER ILE LEU ALA ASP          
SEQRES   3 G  223  LYS SER LEU ALA THR ARG THR ASP GLN ASP SER ARG THR          
SEQRES   4 G  223  ALA LEU HIS TRP ALA CYS SER ALA GLY HIS THR GLU ILE          
SEQRES   5 G  223  VAL GLU PHE LEU LEU GLN LEU GLY VAL PRO VAL ASN ASP          
SEQRES   6 G  223  LYS ASP ASP ALA GLY TRP SER PRO LEU HIS ILE ALA ALA          
SEQRES   7 G  223  SER ALA GLY ARG ASP GLU ILE VAL LYS ALA LEU LEU GLY          
SEQRES   8 G  223  LYS GLY ALA GLN VAL ASN ALA VAL ASN GLN ASN GLY CYS          
SEQRES   9 G  223  THR PRO LEU HIS TYR ALA ALA SER LYS ASN ARG HIS GLU          
SEQRES  10 G  223  ILE ALA VAL MET LEU LEU GLU GLY GLY ALA ASN PRO ASP          
SEQRES  11 G  223  ALA LYS ASP HIS TYR GLU ALA THR ALA MET HIS ARG ALA          
SEQRES  12 G  223  ALA ALA LYS GLY ASN LEU LYS MET ILE HIS ILE LEU LEU          
SEQRES  13 G  223  TYR TYR LYS ALA SER THR ASN ILE GLN ASP THR GLU GLY          
SEQRES  14 G  223  ASN THR PRO LEU HIS LEU ALA CYS ASP GLU GLU ARG VAL          
SEQRES  15 G  223  GLU GLU ALA LYS LEU LEU VAL SER GLN GLY ALA SER ILE          
SEQRES  16 G  223  TYR ILE GLU ASN LYS GLU GLU LYS THR PRO LEU GLN VAL          
SEQRES  17 G  223  ALA LYS GLY GLY LEU GLY LEU ILE LEU LYS ARG MET VAL          
SEQRES  18 G  223  GLU GLY                                                      
SEQRES   1 A  266  PRO THR VAL THR MET MET GLN VAL GLU GLU LYS PRO ASP          
SEQRES   2 A  266  VAL THR TYR SER ASP VAL GLY GLY CYS LYS GLU GLN ILE          
SEQRES   3 A  266  GLU LYS LEU ARG GLU VAL VAL GLU THR PRO LEU LEU HIS          
SEQRES   4 A  266  PRO GLU ARG PHE VAL ASN LEU GLY ILE GLU PRO PRO LYS          
SEQRES   5 A  266  GLY VAL LEU LEU PHE GLY PRO PRO GLY THR GLY LYS THR          
SEQRES   6 A  266  LEU CYS ALA ARG ALA VAL ALA ASN ARG THR ASP ALA CYS          
SEQRES   7 A  266  PHE ILE ARG VAL ILE GLY SER GLU LEU VAL GLN LYS TYR          
SEQRES   8 A  266  VAL GLY GLU GLY ALA ARG MET VAL ARG GLU LEU PHE GLU          
SEQRES   9 A  266  MET ALA ARG THR LYS LYS ALA CYS LEU ILE PHE PHE ASP          
SEQRES  10 A  266  GLU ILE ASP ALA ILE GLY GLY ALA ARG PHE ASP ASP GLY          
SEQRES  11 A  266  ALA GLY GLY ASP ASN GLU VAL GLN ARG THR MET LEU GLU          
SEQRES  12 A  266  LEU ILE ASN GLN LEU ASP GLY PHE ASP PRO ARG GLY ASN          
SEQRES  13 A  266  ILE LYS VAL LEU MET ALA THR ASN ARG PRO ASP THR LEU          
SEQRES  14 A  266  ASP PRO ALA LEU MET ARG PRO GLY ARG LEU ASP ARG LYS          
SEQRES  15 A  266  ILE GLU PHE SER LEU PRO ASP LEU GLU GLY ARG THR HIS          
SEQRES  16 A  266  ILE PHE LYS ILE HIS ALA ARG SER MET SER VAL GLU ARG          
SEQRES  17 A  266  ASP ILE ARG PHE GLU LEU LEU ALA ARG LEU CYS PRO ASN          
SEQRES  18 A  266  SER THR GLY ALA GLU ILE ARG SER VAL CYS THR GLU ALA          
SEQRES  19 A  266  GLY MET PHE ALA ILE ARG ALA ARG ARG LYS ILE ALA THR          
SEQRES  20 A  266  GLU LYS ASP PHE LEU GLU ALA VAL ASN LYS VAL ILE LYS          
SEQRES  21 A  266  SER TYR ALA LYS PHE SER                                      
SEQRES   1 B  266  THR ASP PRO LEU VAL THR VAL MET LYS VAL GLU LYS ALA          
SEQRES   2 B  266  PRO GLN GLU THR TYR ALA ASP ILE GLY GLY LEU ASP ASN          
SEQRES   3 B  266  GLN ILE GLN GLU ILE LYS GLU SER VAL GLU LEU PRO LEU          
SEQRES   4 B  266  THR HIS PRO GLU TYR TYR GLU GLU MET GLY ILE LYS PRO          
SEQRES   5 B  266  PRO LYS GLY VAL ILE LEU TYR GLY PRO PRO GLY THR GLY          
SEQRES   6 B  266  LYS THR LEU LEU ALA LYS ALA VAL ALA ASN GLN THR SER          
SEQRES   7 B  266  ALA THR PHE LEU ARG VAL VAL GLY SER GLU LEU ILE GLN          
SEQRES   8 B  266  LYS TYR LEU GLY ASP GLY PRO LYS LEU VAL ARG GLU LEU          
SEQRES   9 B  266  PHE ARG VAL ALA GLU GLU HIS ALA PRO SER ILE VAL PHE          
SEQRES  10 B  266  ILE ASP GLU ILE ASP ALA ILE GLY THR LYS ARG TYR ASP          
SEQRES  11 B  266  SER ASN SER GLY GLY GLU ARG GLU ILE GLN ARG THR MET          
SEQRES  12 B  266  LEU GLU LEU LEU ASN GLN LEU ASP GLY PHE ASP SER ARG          
SEQRES  13 B  266  GLY ASP VAL LYS VAL ILE MET ALA THR ASN ARG ILE GLU          
SEQRES  14 B  266  THR LEU ASP PRO ALA LEU ILE ARG PRO GLY ARG ILE ASP          
SEQRES  15 B  266  ARG LYS ILE GLU PHE PRO LEU PRO ASP GLU LYS THR LYS          
SEQRES  16 B  266  LYS ARG ILE PHE GLN ILE HIS THR SER ARG MET THR LEU          
SEQRES  17 B  266  ALA ASP ASP VAL THR LEU ASP ASP LEU ILE MET ALA LYS          
SEQRES  18 B  266  ASP ASP LEU SER GLY ALA ASP ILE LYS ALA ILE CYS THR          
SEQRES  19 B  266  GLU ALA GLY LEU MET ALA LEU ARG GLU ARG ARG MET LYS          
SEQRES  20 B  266  VAL THR ASN GLU ASP PHE LYS LYS SER LYS GLU ASN VAL          
SEQRES  21 B  266  LEU TYR LYS LYS GLN GLU                                      
SEQRES   1 D  262  PRO GLU ALA ASP SER SER ILE MET MET LEU THR SER ASP          
SEQRES   2 D  262  GLN LYS PRO ASP VAL MET TYR ALA ASP ILE GLY GLY MET          
SEQRES   3 D  262  ASP ILE GLN LYS GLN GLU VAL ARG GLU ALA VAL GLU LEU          
SEQRES   4 D  262  PRO LEU THR HIS PHE GLU LEU TYR LYS GLN ILE GLY ILE          
SEQRES   5 D  262  ASP PRO PRO ARG GLY VAL LEU MET TYR GLY PRO PRO GLY          
SEQRES   6 D  262  CYS GLY LYS THR MET LEU ALA LYS ALA VAL ALA HIS HIS          
SEQRES   7 D  262  THR THR ALA ALA PHE ILE ARG VAL VAL GLY SER GLU PHE          
SEQRES   8 D  262  VAL GLN LYS TYR LEU GLY GLU GLY PRO ARG MET VAL ARG          
SEQRES   9 D  262  ASP VAL PHE ARG LEU ALA LYS GLU ASN ALA PRO ALA ILE          
SEQRES  10 D  262  ILE PHE ILE ASP GLU ILE ASP ALA ILE ALA THR LYS ARG          
SEQRES  11 D  262  PHE ASP ALA GLN THR GLY ALA ASP ARG GLU VAL GLN ARG          
SEQRES  12 D  262  ILE LEU LEU GLU LEU LEU ASN GLN MET ASP GLY PHE ASP          
SEQRES  13 D  262  GLN ASN VAL ASN VAL LYS VAL ILE MET ALA THR ASN ARG          
SEQRES  14 D  262  ALA ASP THR LEU ASP PRO ALA LEU LEU ARG PRO GLY ARG          
SEQRES  15 D  262  LEU ASP ARG LYS ILE GLU PHE PRO LEU PRO ASP ARG ARG          
SEQRES  16 D  262  GLN LYS ARG LEU ILE PHE SER THR ILE THR SER LYS MET          
SEQRES  17 D  262  ASN LEU SER GLU GLU VAL ASP LEU GLU ASP TYR VAL ALA          
SEQRES  18 D  262  ARG PRO ASP LYS ILE SER GLY ALA ASP ILE ASN SER ILE          
SEQRES  19 D  262  CYS GLN GLU SER GLY MET LEU ALA VAL ARG GLU ASN ARG          
SEQRES  20 D  262  TYR ILE VAL LEU ALA LYS ASP PHE GLU LYS ALA TYR LYS          
SEQRES  21 D  262  THR VAL                                                      
SEQRES   1 E  275  VAL ASP PRO LEU VAL TYR ASN MET SER HIS GLU ASP PRO          
SEQRES   2 E  275  GLY ASN VAL SER TYR SER GLU ILE GLY GLY LEU SER GLU          
SEQRES   3 E  275  GLN ILE ARG GLU LEU ARG GLU VAL ILE GLU LEU PRO LEU          
SEQRES   4 E  275  THR ASN PRO GLU LEU PHE GLN ARG VAL GLY ILE ILE PRO          
SEQRES   5 E  275  PRO LYS GLY CYS LEU LEU TYR GLY PRO PRO GLY THR GLY          
SEQRES   6 E  275  LYS THR LEU LEU ALA ARG ALA VAL ALA SER GLN LEU ASP          
SEQRES   7 E  275  CYS ASN PHE LEU LYS VAL VAL SER SER SER ILE VAL ASP          
SEQRES   8 E  275  LYS TYR ILE GLY GLU SER ALA ARG LEU ILE ARG GLU MET          
SEQRES   9 E  275  PHE ASN TYR ALA ARG ASP HIS GLN PRO CYS ILE ILE PHE          
SEQRES  10 E  275  MET ASP GLU ILE ASP ALA ILE GLY GLY ARG ARG PHE SER          
SEQRES  11 E  275  GLU GLY THR SER ALA ASP ARG GLU ILE GLN ARG THR LEU          
SEQRES  12 E  275  MET GLU LEU LEU ASN GLN MET ASP GLY PHE ASP THR LEU          
SEQRES  13 E  275  HIS ARG VAL LYS MET ILE MET ALA THR ASN ARG PRO ASP          
SEQRES  14 E  275  THR LEU ASP PRO ALA LEU LEU ARG PRO GLY ARG LEU ASP          
SEQRES  15 E  275  ARG LYS ILE HIS ILE ASP LEU PRO ASN GLU GLN ALA ARG          
SEQRES  16 E  275  LEU ASP ILE LEU LYS ILE HIS ALA GLY PRO ILE THR LYS          
SEQRES  17 E  275  HIS GLY GLU ILE ASP TYR GLU ALA ILE VAL LYS LEU SER          
SEQRES  18 E  275  ASP GLY PHE ASN GLY ALA ASP LEU ARG ASN VAL CYS THR          
SEQRES  19 E  275  GLU ALA GLY MET PHE ALA ILE ARG ALA ASP HIS ASP PHE          
SEQRES  20 E  275  VAL VAL GLN GLU ASP PHE MET LYS ALA VAL ARG LYS VAL          
SEQRES  21 E  275  ALA ASP SER LYS LYS LEU GLU SER LYS LEU ASP TYR LYS          
SEQRES  22 E  275  PRO VAL                                                      
SEQRES   1 F  267  THR GLU TYR ASP SER ARG VAL LYS ALA MET GLU VAL ASP          
SEQRES   2 F  267  GLU ARG PRO THR GLU GLN TYR SER ASP ILE GLY GLY LEU          
SEQRES   3 F  267  ASP LYS GLN ILE GLN GLU LEU VAL GLU ALA ILE VAL LEU          
SEQRES   4 F  267  PRO MET ASN HIS LYS GLU LYS PHE GLU ASN LEU GLY ILE          
SEQRES   5 F  267  GLN PRO PRO LYS GLY VAL LEU MET TYR GLY PRO PRO GLY          
SEQRES   6 F  267  THR GLY LYS THR LEU LEU ALA ARG ALA CYS ALA ALA GLN          
SEQRES   7 F  267  THR LYS ALA THR PHE LEU LYS LEU ALA GLY PRO GLN LEU          
SEQRES   8 F  267  VAL GLN MET PHE ILE GLY ASP GLY ALA LYS LEU VAL ARG          
SEQRES   9 F  267  ASP ALA PHE ALA LEU ALA LYS GLU LYS ALA PRO SER ILE          
SEQRES  10 F  267  ILE PHE ILE ASP GLU LEU ASP ALA ILE GLY THR LYS ARG          
SEQRES  11 F  267  PHE ASP SER GLU LYS ALA GLY ASP ARG GLU VAL GLN ARG          
SEQRES  12 F  267  THR MET LEU GLU LEU LEU ASN GLN LEU ASP GLY PHE GLN          
SEQRES  13 F  267  PRO ASN THR GLN VAL LYS VAL ILE ALA ALA THR ASN ARG          
SEQRES  14 F  267  VAL ASP ILE LEU ASP PRO ALA LEU LEU ARG SER GLY ARG          
SEQRES  15 F  267  LEU ASP ARG LYS ILE GLU PHE PRO MET PRO ASN GLU GLU          
SEQRES  16 F  267  ALA ARG ALA ARG ILE MET GLN ILE HIS SER ARG LYS MET          
SEQRES  17 F  267  ASN VAL SER PRO ASP VAL ASN TYR GLU GLU LEU ALA ARG          
SEQRES  18 F  267  CYS THR ASP ASP PHE ASN GLY ALA GLN CYS LYS ALA VAL          
SEQRES  19 F  267  CYS VAL GLU ALA GLY MET ILE ALA LEU ARG ARG GLY ALA          
SEQRES  20 F  267  THR GLU LEU THR HIS GLU ASP TYR MET GLU GLY ILE LEU          
SEQRES  21 F  267  GLU VAL GLN ALA LYS LYS LYS                                  
SEQRES   1 C  266  LYS VAL ASP PRO LEU VAL SER LEU MET MET VAL GLU LYS          
SEQRES   2 C  266  VAL PRO ASP SER THR TYR GLU MET ILE GLY GLY LEU ASP          
SEQRES   3 C  266  LYS GLN ILE LYS GLU ILE LYS GLU VAL ILE GLU LEU PRO          
SEQRES   4 C  266  VAL LYS HIS PRO GLU LEU PHE GLU ALA LEU GLY ILE ALA          
SEQRES   5 C  266  GLN PRO LYS GLY VAL LEU LEU TYR GLY PRO PRO GLY THR          
SEQRES   6 C  266  GLY LYS THR LEU LEU ALA ARG ALA VAL ALA HIS HIS THR          
SEQRES   7 C  266  ASP CYS THR PHE ILE ARG VAL SER GLY SER GLU LEU VAL          
SEQRES   8 C  266  GLN LYS PHE ILE GLY GLU GLY ALA ARG MET VAL ARG GLU          
SEQRES   9 C  266  LEU PHE VAL MET ALA ARG GLU HIS ALA PRO SER ILE ILE          
SEQRES  10 C  266  PHE MET ASP GLU ILE ASP SER ILE GLY SER SER ARG LEU          
SEQRES  11 C  266  GLU GLY GLY SER GLY GLY ASP SER GLU VAL GLN ARG THR          
SEQRES  12 C  266  MET LEU GLU LEU LEU ASN GLN LEU ASP GLY PHE GLU ALA          
SEQRES  13 C  266  THR LYS ASN ILE LYS VAL ILE MET ALA THR ASN ARG ILE          
SEQRES  14 C  266  ASP ILE LEU ASP SER ALA LEU LEU ARG PRO GLY ARG ILE          
SEQRES  15 C  266  ASP ARG LYS ILE GLU PHE PRO PRO PRO ASN GLU GLU ALA          
SEQRES  16 C  266  ARG LEU ASP ILE LEU LYS ILE HIS SER ARG LYS MET ASN          
SEQRES  17 C  266  LEU THR ARG GLY ILE ASN LEU ARG LYS ILE ALA GLU LEU          
SEQRES  18 C  266  MET PRO GLY ALA SER GLY ALA GLU VAL LYS GLY VAL CYS          
SEQRES  19 C  266  THR GLU ALA GLY MET TYR ALA LEU ARG GLU ARG ARG VAL          
SEQRES  20 C  266  HIS VAL THR GLN GLU ASP PHE GLU MET ALA VAL ALA LYS          
SEQRES  21 C  266  VAL MET GLN LYS ASP SER                                      
SEQRES   1 f  848  ARG ASP LYS ALA PRO VAL GLN PRO GLN GLN SER PRO ALA          
SEQRES   2 f  848  ALA ALA PRO GLY GLY THR ASP GLU LYS PRO SER GLY LYS          
SEQRES   3 f  848  GLU ARG ARG ASP ALA GLY ASP LYS ASP LYS GLU GLN GLU          
SEQRES   4 f  848  LEU SER GLU GLU ASP LYS GLN LEU GLN ASP GLU LEU GLU          
SEQRES   5 f  848  MET LEU VAL GLU ARG LEU GLY GLU LYS ASP THR SER LEU          
SEQRES   6 f  848  TYR ARG PRO ALA LEU GLU GLU LEU ARG ARG GLN ILE ARG          
SEQRES   7 f  848  SER SER THR THR SER MET THR SER VAL PRO LYS PRO LEU          
SEQRES   8 f  848  LYS PHE LEU ARG PRO HIS TYR GLY LYS LEU LYS GLU ILE          
SEQRES   9 f  848  TYR GLU ASN MET ALA PRO GLY GLU ASN LYS ARG PHE ALA          
SEQRES  10 f  848  ALA ASP ILE ILE SER VAL LEU ALA MET THR MET SER GLY          
SEQRES  11 f  848  GLU ARG GLU CYS LEU LYS TYR ARG LEU VAL GLY SER GLN          
SEQRES  12 f  848  GLU GLU LEU ALA SER TRP GLY HIS GLU TYR VAL ARG HIS          
SEQRES  13 f  848  LEU ALA GLY GLU VAL ALA LYS GLU TRP GLN GLU LEU ASP          
SEQRES  14 f  848  ASP ALA GLU LYS VAL GLN ARG GLU PRO LEU LEU THR LEU          
SEQRES  15 f  848  VAL LYS GLU ILE VAL PRO TYR ASN MET ALA HIS ASN ALA          
SEQRES  16 f  848  GLU HIS GLU ALA CYS ASP LEU LEU MET GLU ILE GLU GLN          
SEQRES  17 f  848  VAL ASP MET LEU GLU LYS ASP ILE ASP GLU ASN ALA TYR          
SEQRES  18 f  848  ALA LYS VAL CYS LEU TYR LEU THR SER CYS VAL ASN TYR          
SEQRES  19 f  848  VAL PRO GLU PRO GLU ASN SER ALA LEU LEU ARG CYS ALA          
SEQRES  20 f  848  LEU GLY VAL PHE ARG LYS PHE SER ARG PHE PRO GLU ALA          
SEQRES  21 f  848  LEU ARG LEU ALA LEU MET LEU ASN ASP MET GLU LEU VAL          
SEQRES  22 f  848  GLU ASP ILE PHE THR SER CYS LYS ASP VAL VAL VAL GLN          
SEQRES  23 f  848  LYS GLN MET ALA PHE MET LEU GLY ARG HIS GLY VAL PHE          
SEQRES  24 f  848  LEU GLU LEU SER GLU ASP VAL GLU GLU TYR GLU ASP LEU          
SEQRES  25 f  848  THR GLU ILE MET SER ASN VAL GLN LEU ASN SER ASN PHE          
SEQRES  26 f  848  LEU ALA LEU ALA ARG GLU LEU ASP ILE MET GLU PRO LYS          
SEQRES  27 f  848  VAL PRO ASP ASP ILE TYR LYS THR HIS LEU GLU ASN ASN          
SEQRES  28 f  848  ARG PHE GLY GLY SER GLY SER GLN VAL ASP SER ALA ARG          
SEQRES  29 f  848  MET ASN LEU ALA SER SER PHE VAL ASN GLY PHE VAL ASN          
SEQRES  30 f  848  ALA ALA PHE GLY GLN ASP LYS LEU LEU THR ASP ASP GLY          
SEQRES  31 f  848  ASN LYS TRP LEU TYR LYS ASN LYS ASP HIS GLY MET LEU          
SEQRES  32 f  848  SER ALA ALA ALA SER LEU GLY MET ILE LEU LEU TRP ASP          
SEQRES  33 f  848  VAL ASP GLY GLY LEU THR GLN ILE ASP LYS TYR LEU TYR          
SEQRES  34 f  848  SER SER GLU ASP TYR ILE LYS SER GLY ALA LEU LEU ALA          
SEQRES  35 f  848  CYS GLY ILE VAL ASN SER GLY VAL ARG ASN GLU CYS ASP          
SEQRES  36 f  848  PRO ALA LEU ALA LEU LEU SER ASP TYR VAL LEU HIS ASN          
SEQRES  37 f  848  SER ASN THR MET ARG LEU GLY SER ILE PHE GLY LEU GLY          
SEQRES  38 f  848  LEU ALA TYR ALA GLY SER ASN ARG GLU ASP VAL LEU THR          
SEQRES  39 f  848  LEU LEU LEU PRO VAL MET GLY ASP SER LYS SER SER MET          
SEQRES  40 f  848  GLU VAL ALA GLY VAL THR ALA LEU ALA CYS GLY MET ILE          
SEQRES  41 f  848  ALA VAL GLY SER CYS ASN GLY ASP VAL THR SER THR ILE          
SEQRES  42 f  848  LEU GLN THR ILE MET GLU LYS SER GLU THR GLU LEU LYS          
SEQRES  43 f  848  ASP THR TYR ALA ARG TRP LEU PRO LEU GLY LEU GLY LEU          
SEQRES  44 f  848  ASN HIS LEU GLY LYS GLY GLU ALA ILE GLU ALA ILE LEU          
SEQRES  45 f  848  ALA ALA LEU GLU VAL VAL SER GLU PRO PHE ARG SER PHE          
SEQRES  46 f  848  ALA ASN THR LEU VAL ASP VAL CYS ALA TYR ALA GLY SER          
SEQRES  47 f  848  GLY ASN VAL LEU LYS VAL GLN GLN LEU LEU HIS ILE CYS          
SEQRES  48 f  848  SER GLU HIS PHE ASP SER LYS GLU LYS GLU GLU ASP LYS          
SEQRES  49 f  848  ASP LYS LYS GLU LYS LYS ASP LYS ASP LYS LYS GLU ALA          
SEQRES  50 f  848  PRO ALA ASP MET GLY ALA HIS GLN GLY VAL ALA VAL LEU          
SEQRES  51 f  848  GLY ILE ALA LEU ILE ALA MET GLY GLU GLU ILE GLY ALA          
SEQRES  52 f  848  GLU MET ALA LEU ARG THR PHE GLY HIS LEU LEU ARG TYR          
SEQRES  53 f  848  GLY GLU PRO THR LEU ARG ARG ALA VAL PRO LEU ALA LEU          
SEQRES  54 f  848  ALA LEU ILE SER VAL SER ASN PRO ARG LEU ASN ILE LEU          
SEQRES  55 f  848  ASP THR LEU SER LYS PHE SER HIS ASP ALA ASP PRO GLU          
SEQRES  56 f  848  VAL SER TYR ASN SER ILE PHE ALA MET GLY MET VAL GLY          
SEQRES  57 f  848  SER GLY THR ASN ASN ALA ARG LEU ALA ALA MET LEU ARG          
SEQRES  58 f  848  GLN LEU ALA GLN TYR HIS ALA LYS ASP PRO ASN ASN LEU          
SEQRES  59 f  848  PHE MET VAL ARG LEU ALA GLN GLY LEU THR HIS LEU GLY          
SEQRES  60 f  848  LYS GLY THR LEU THR LEU CYS PRO TYR HIS SER ASP ARG          
SEQRES  61 f  848  GLN LEU MET SER GLN VAL ALA VAL ALA GLY LEU LEU THR          
SEQRES  62 f  848  VAL LEU VAL SER PHE LEU ASP VAL ARG ASN ILE ILE LEU          
SEQRES  63 f  848  GLY LYS SER HIS TYR VAL LEU TYR GLY LEU VAL ALA ALA          
SEQRES  64 f  848  MET GLN PRO ARG MET LEU VAL THR PHE ASP GLU GLU LEU          
SEQRES  65 f  848  ARG PRO LEU PRO VAL SER VAL ARG VAL GLY GLN ALA VAL          
SEQRES  66 f  848  ASP VAL VAL                                                  
HELIX    1 AA1 LEU G    8  GLY G   17  1                                  10    
HELIX    2 AA2 LYS G   18  ASP G   29  1                                  12    
HELIX    3 AA3 LYS G   30  ARG G   35  1                                   6    
HELIX    4 AA4 THR G   42  ALA G   50  1                                   9    
HELIX    5 AA5 HIS G   52  GLY G   63  1                                  12    
HELIX    6 AA6 SER G   75  GLY G   84  1                                  10    
HELIX    7 AA7 ARG G   85  GLY G   96  1                                  12    
HELIX    8 AA8 THR G  108  LYS G  116  1                                   9    
HELIX    9 AA9 ARG G  118  GLY G  129  1                                  12    
HELIX   10 AB1 THR G  141  GLY G  150  1                                  10    
HELIX   11 AB2 ASN G  151  TYR G  160  1                                  10    
HELIX   12 AB3 THR G  174  GLU G  182  1                                   9    
HELIX   13 AB4 ARG G  184  GLN G  194  1                                  11    
HELIX   14 AB5 THR G  207  ALA G  212  1                                   6    
HELIX   15 AB6 GLY G  215  GLY G  226  1                                  12    
HELIX   16 AB7 THR A  160  GLN A  165  1                                   6    
HELIX   17 AB8 THR A  173  VAL A  177  5                                   5    
HELIX   18 AB9 GLU A  182  GLU A  192  1                                  11    
HELIX   19 AC1 GLU A  192  HIS A  197  1                                   6    
HELIX   20 AC2 HIS A  197  LEU A  204  1                                   8    
HELIX   21 AC3 LYS A  222  ARG A  232  1                                  11    
HELIX   22 AC4 GLY A  251  LYS A  267  1                                  17    
HELIX   23 AC5 GLU A  276  ILE A  280  5                                   5    
HELIX   24 AC6 ASP A  292  ASP A  307  1                                  16    
HELIX   25 AC7 THR A  326  ARG A  333  1                                   8    
HELIX   26 AC8 PRO A  334  ARG A  336  5                                   3    
HELIX   27 AC9 ASP A  347  HIS A  358  1                                  12    
HELIX   28 AD1 ALA A  359  SER A  361  5                                   3    
HELIX   29 AD2 ARG A  369  LEU A  376  1                                   8    
HELIX   30 AD3 THR A  381  ARG A  398  1                                  18    
HELIX   31 AD4 THR A  405  SER A  424  1                                  20    
HELIX   32 AD5 PRO B  169  VAL B  173  1                                   5    
HELIX   33 AD6 LEU B  190  GLU B  202  1                                  13    
HELIX   34 AD7 HIS B  207  TYR B  211  5                                   5    
HELIX   35 AD8 GLY B  231  VAL B  239  1                                   9    
HELIX   36 AD9 ALA B  240  THR B  243  5                                   4    
HELIX   37 AE1 SER B  253  LYS B  258  1                                   6    
HELIX   38 AE2 PRO B  264  GLU B  276  1                                  13    
HELIX   39 AE3 GLU B  302  ASP B  317  1                                  16    
HELIX   40 AE4 ASP B  338  ILE B  342  5                                   5    
HELIX   41 AE5 GLU B  358  THR B  369  1                                  12    
HELIX   42 AE6 ASP B  382  LYS B  387  1                                   6    
HELIX   43 AE7 SER B  391  ARG B  408  1                                  18    
HELIX   44 AE8 THR B  415  LYS B  430  1                                  16    
HELIX   45 AE9 ASP D  171  THR D  186  1                                  16    
HELIX   46 AF1 THR D  213  THR D  223  1                                  11    
HELIX   47 AF2 SER D  233  VAL D  236  5                                   4    
HELIX   48 AF3 GLY D  241  ALA D  258  1                                  18    
HELIX   49 AF4 THR D  279  PHE D  299  1                                  21    
HELIX   50 AF5 ASP D  337  SER D  350  1                                  14    
HELIX   51 AF6 GLU D  361  ILE D  370  1                                  10    
HELIX   52 AF7 ASP D  374  ALA D  386  1                                  13    
HELIX   53 AF8 LEU D  395  VAL D  406  1                                  12    
HELIX   54 AF9 ASP E  116  MET E  122  1                                   7    
HELIX   55 AG1 VAL E  130  GLU E  134  5                                   5    
HELIX   56 AG2 GLY E  179  LEU E  191  1                                  13    
HELIX   57 AG3 SER E  211  HIS E  225  1                                  15    
HELIX   58 AG4 THR E  247  ASP E  265  1                                  19    
HELIX   59 AG5 ASN E  305  ALA E  317  1                                  13    
HELIX   60 AG6 TYR E  328  SER E  335  1                                   8    
HELIX   61 AG7 ASN E  339  ILE E  355  1                                  17    
HELIX   62 AG8 ARG E  356  ASP E  358  5                                   3    
HELIX   63 AG9 GLN E  364  GLU E  381  1                                  18    
HELIX   64 AH1 ASP F  169  ALA F  174  1                                   6    
HELIX   65 AH2 GLN F  184  ILE F  188  5                                   5    
HELIX   66 AH3 LEU F  191  HIS F  208  1                                  18    
HELIX   67 AH4 GLU F  210  GLY F  216  1                                   7    
HELIX   68 AH5 GLY F  232  LYS F  245  1                                  14    
HELIX   69 AH6 PRO F  254  LEU F  256  5                                   3    
HELIX   70 AH7 GLY F  262  LYS F  278  1                                  17    
HELIX   71 AH8 ALA F  301  LEU F  317  1                                  17    
HELIX   72 AH9 ASN F  358  SER F  370  1                                  13    
HELIX   73 AI1 TYR F  381  THR F  388  1                                   8    
HELIX   74 AI2 ASN F  392  ARG F  410  1                                  19    
HELIX   75 AI3 GLU F  418  GLN F  428  1                                  11    
HELIX   76 AI4 ASP C  155  LYS C  162  1                                   8    
HELIX   77 AI5 GLU C  166  HIS C  171  1                                   6    
HELIX   78 AI6 THR C  197  ASP C  208  1                                  12    
HELIX   79 AI7 ARG C  232  HIS C  241  1                                  10    
HELIX   80 AI8 GLU C  260  LEU C  280  1                                  21    
HELIX   81 AI9 ILE C  298  ARG C  307  1                                  10    
HELIX   82 AJ1 GLU C  322  LYS C  335  1                                  14    
HELIX   83 AJ2 ASN C  343  LEU C  350  1                                   8    
HELIX   84 AJ3 GLY C  356  GLU C  365  1                                  10    
HELIX   85 AJ4 ALA C  366  ARG C  374  1                                   9    
HELIX   86 AJ5 THR C  379  ASP C  394  1                                  16    
HELIX   87 AJ6 VAL f   11  GLN f   15  5                                   5    
HELIX   88 AJ7 ALA f   19  ARG f   33  1                                  15    
HELIX   89 AJ8 GLU f   44  ASP f   49  1                                   6    
HELIX   90 AJ9 TYR f   71  SER f   84  1                                  14    
HELIX   91 AK1 PRO f   93  PHE f   98  1                                   6    
HELIX   92 AK2 LYS f  119  LEU f  144  1                                  26    
HELIX   93 AK3 GLY f  164  ARG f  181  1                                  18    
HELIX   94 AK4 LEU f  185  GLU f  190  1                                   6    
HELIX   95 AK5 LEU f  208  LEU f  217  1                                  10    
HELIX   96 AK6 ILE f  221  TYR f  239  1                                  19    
HELIX   97 AK7 PRO f  241  PHE f  259  1                                  19    
HELIX   98 AK8 ARG f  261  ASN f  273  1                                  13    
HELIX   99 AK9 ASP f  274  VAL f  288  1                                  15    
HELIX  100 AL1 LEU f  298  GLU f  309  1                                  12    
HELIX  101 AL2 ASP f  310  GLN f  325  1                                  16    
HELIX  102 AL3 SER f  328  ALA f  334  1                                   7    
HELIX  103 AL4 GLU f  336  GLU f  341  1                                   6    
HELIX  104 AL5 PRO f  342  THR f  351  1                                  10    
HELIX  105 AL6 ASN f  355  GLY f  360  1                                   6    
HELIX  106 AL7 ARG f  369  GLY f  379  1                                  11    
HELIX  107 AL8 PHE f  380  ASN f  382  5                                   3    
HELIX  108 AL9 LYS f  403  ILE f  417  1                                  15    
HELIX  109 AM1 ASP f  421  ASP f  430  1                                  10    
HELIX  110 AM2 GLU f  437  VAL f  451  1                                  15    
HELIX  111 AM3 CYS f  459  ALA f  464  1                                   6    
HELIX  112 AM4 ASN f  475  TYR f  489  1                                  15    
HELIX  113 AM5 ARG f  494  GLY f  506  1                                  13    
HELIX  114 AM6 SER f  511  ALA f  526  1                                  16    
HELIX  115 AM7 THR f  535  GLU f  544  1                                  10    
HELIX  116 AM8 ASP f  552  LEU f  567  1                                  16    
HELIX  117 AM9 ILE f  573  VAL f  582  1                                  10    
HELIX  118 AN1 GLU f  585  ALA f  599  1                                  15    
HELIX  119 AN2 VAL f  606  ILE f  615  1                                  10    
HELIX  120 AN3 CYS f  616  GLU f  618  5                                   3    
HELIX  121 AN4 SER f  622  ASP f  628  1                                   7    
HELIX  122 AN5 ASP f  630  LYS f  635  1                                   6    
HELIX  123 AN6 ASP f  645  HIS f  649  5                                   5    
HELIX  124 AN7 GLY f  651  MET f  662  1                                  12    
HELIX  125 AN8 ALA f  668  LEU f  679  1                                  12    
HELIX  126 AN9 GLU f  683  ILE f  697  1                                  15    
HELIX  127 AO1 ALA f  717  ALA f  728  1                                  12    
HELIX  128 AO2 ARG f  740  LYS f  754  1                                  15    
HELIX  129 AO3 GLY f  774  THR f  777  5                                   4    
HELIX  130 AO4 LEU f  778  ASP f  784  1                                   7    
HELIX  131 AO5 ARG f  785  LEU f  787  5                                   3    
HELIX  132 AO6 VAL f  793  THR f  798  1                                   6    
SHEET    1 AA1 2 LEU A 213  PHE A 215  0                                        
SHEET    2 AA1 2 LYS A 340  GLU A 342  1  O  ILE A 341   N  LEU A 213           
SHEET    1 AA2 2 ILE A 238  VAL A 240  0                                        
SHEET    2 AA2 2 ILE A 272  PHE A 274  1  O  PHE A 273   N  VAL A 240           
SHEET    1 AA3 4 ILE B 223  TYR B 225  0                                        
SHEET    2 AA3 4 LYS B 326  THR B 331  1  O  MET B 329   N  LEU B 224           
SHEET    3 AA3 4 ILE B 281  ASP B 285  1  N  VAL B 282   O  ILE B 328           
SHEET    4 AA3 4 LEU B 248  VAL B 251  1  N  VAL B 250   O  ASP B 285           
SHEET    1 AA4 2 THR B 373  LEU B 374  0                                        
SHEET    2 AA4 2 LYS B 413  VAL B 414  1  O  VAL B 414   N  THR B 373           
SHEET    1 AA5 5 PHE D 227  VAL D 231  0                                        
SHEET    2 AA5 5 ALA D 260  ASP D 265  1  O  PHE D 263   N  ILE D 228           
SHEET    3 AA5 5 VAL D 305  ALA D 310  1  O  LYS D 306   N  ILE D 262           
SHEET    4 AA5 5 GLY D 201  MET D 204  1  N  VAL D 202   O  MET D 309           
SHEET    5 AA5 5 ARG D 329  LYS D 330  1  O  ARG D 329   N  LEU D 203           
SHEET    1 AA6 5 LYS E 197  VAL E 199  0                                        
SHEET    2 AA6 5 ILE E 229  ASP E 233  1  O  PHE E 231   N  VAL E 198           
SHEET    3 AA6 5 LYS E 274  THR E 279  1  O  ALA E 278   N  MET E 232           
SHEET    4 AA6 5 GLY E 169  TYR E 173  1  N  LEU E 172   O  THR E 279           
SHEET    5 AA6 5 LEU E 295  ILE E 299  1  O  ILE E 299   N  LEU E 171           
SHEET    1 AA7 3 VAL F 328  THR F 332  0                                        
SHEET    2 AA7 3 GLY F 222  TYR F 226  1  N  MET F 225   O  ALA F 330           
SHEET    3 AA7 3 LEU F 348  LYS F 351  1  O  ARG F 350   N  LEU F 224           
SHEET    1 AA8 2 THR F 247  ALA F 252  0                                        
SHEET    2 AA8 2 SER F 281  ASP F 286  1  O  ILE F 282   N  THR F 247           
SHEET    1 AA9 3 VAL C 291  MET C 293  0                                        
SHEET    2 AA9 3 GLY C 185  LEU C 187  1  N  VAL C 186   O  MET C 293           
SHEET    3 AA9 3 ARG C 313  LYS C 314  1  O  ARG C 313   N  GLY C 185           
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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