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Database: PDB
Entry: 5VHP
LinkDB: 5VHP
Original site: 5VHP 
HEADER    HYDROLASE                               13-APR-17   5VHP              
TITLE     CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY 
TITLE    2 PARTICLE                                                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10;           
COMPND   3 CHAIN: G;                                                            
COMPND   4 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT P28,GANKYRIN,P28(GANK);   
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 7;                       
COMPND   8 CHAIN: A;                                                            
COMPND   9 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT1,PROTEASOME 26S       
COMPND  10 SUBUNIT ATPASE 2,PROTEIN MSS1;                                       
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 4;                       
COMPND  14 CHAIN: B;                                                            
COMPND  15 SYNONYM: P26S4,26S PROTEASOME AAA-ATPASE SUBUNIT RPT2,PROTEASOME 26S 
COMPND  16 SUBUNIT ATPASE 1;                                                    
COMPND  17 ENGINEERED: YES;                                                     
COMPND  18 MOL_ID: 4;                                                           
COMPND  19 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 6B;                      
COMPND  20 CHAIN: D;                                                            
COMPND  21 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT3,MB67-INTERACTING     
COMPND  22 PROTEIN,MIP224,PROTEASOME 26S SUBUNIT ATPASE 4,TAT-BINDING PROTEIN 7,
COMPND  23 TBP-7;                                                               
COMPND  24 ENGINEERED: YES;                                                     
COMPND  25 MOL_ID: 5;                                                           
COMPND  26 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 10B;                     
COMPND  27 CHAIN: E;                                                            
COMPND  28 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT4,PROTEASOME 26S       
COMPND  29 SUBUNIT ATPASE 6,PROTEASOME SUBUNIT P42;                             
COMPND  30 ENGINEERED: YES;                                                     
COMPND  31 MOL_ID: 6;                                                           
COMPND  32 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 6A;                      
COMPND  33 CHAIN: F;                                                            
COMPND  34 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT5,PROTEASOME 26S       
COMPND  35 SUBUNIT ATPASE 3,PROTEASOME SUBUNIT P50,TAT-BINDING PROTEIN 1,TBP-1; 
COMPND  36 ENGINEERED: YES;                                                     
COMPND  37 MOL_ID: 7;                                                           
COMPND  38 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT 8;                       
COMPND  39 CHAIN: C;                                                            
COMPND  40 SYNONYM: 26S PROTEASOME AAA-ATPASE SUBUNIT RPT6,PROTEASOME 26S       
COMPND  41 SUBUNIT ATPASE 5,PROTEASOME SUBUNIT P45,THYROID HORMONE RECEPTOR-    
COMPND  42 INTERACTING PROTEIN 1,TRIP1,P45/SUG;                                 
COMPND  43 ENGINEERED: YES;                                                     
COMPND  44 MOL_ID: 8;                                                           
COMPND  45 MOLECULE: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2;            
COMPND  46 CHAIN: f;                                                            
COMPND  47 SYNONYM: 26S PROTEASOME REGULATORY SUBUNIT RPN1,26S PROTEASOME       
COMPND  48 REGULATORY SUBUNIT S2,26S PROTEASOME SUBUNIT P97,PROTEIN 55.11,TUMOR 
COMPND  49 NECROSIS FACTOR TYPE 1 RECEPTOR-ASSOCIATED PROTEIN 2;                
COMPND  50 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: PSMD10;                                                        
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 GENE: PSMC2, MSS1;                                                   
SOURCE  14 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  15 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  17 MOL_ID: 3;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 GENE: PSMC1;                                                         
SOURCE  22 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  23 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  24 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  25 MOL_ID: 4;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 GENE: PSMC4, MIP224, TBP7;                                           
SOURCE  30 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  31 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  32 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  33 MOL_ID: 5;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  35 ORGANISM_COMMON: HUMAN;                                              
SOURCE  36 ORGANISM_TAXID: 9606;                                                
SOURCE  37 GENE: PSMC6, SUG2;                                                   
SOURCE  38 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  39 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  40 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  41 MOL_ID: 6;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 GENE: PSMC3, TBP1;                                                   
SOURCE  46 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  47 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  48 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  49 MOL_ID: 7;                                                           
SOURCE  50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  51 ORGANISM_COMMON: HUMAN;                                              
SOURCE  52 ORGANISM_TAXID: 9606;                                                
SOURCE  53 GENE: PSMC5, SUG1;                                                   
SOURCE  54 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  55 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  56 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  57 MOL_ID: 8;                                                           
SOURCE  58 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  59 ORGANISM_COMMON: HUMAN;                                              
SOURCE  60 ORGANISM_TAXID: 9606;                                                
SOURCE  61 GENE: PSMD2, TRAP2;                                                  
SOURCE  62 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  63 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  64 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    P28, 26S PROTEASOME, REGULATORY PARTICLE, 19S, GANKYRIN, HYDROLASE    
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    Y.LU,J.WU,Y.DONG,S.CHEN,S.SUN,Y.B.MA,Q.OUYANG,D.FINLEY,M.W.KIRSCHNER, 
AUTHOR   2 Y.MAO                                                                
REVDAT   2   22-AUG-18 5VHP    1       REMARK                                   
REVDAT   1   23-AUG-17 5VHP    0                                                
JRNL        AUTH   Y.LU,J.WU,Y.DONG,S.CHEN,S.SUN,Y.B.MA,Q.OUYANG,D.FINLEY,      
JRNL        AUTH 2 M.W.KIRSCHNER,Y.MAO                                          
JRNL        TITL   CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME   
JRNL        TITL 2 REGULATORY PARTICLE.                                         
JRNL        REF    MOL. CELL                     V.  67   322 2017              
JRNL        REFN                   ISSN 1097-4164                               
JRNL        PMID   28689658                                                     
JRNL        DOI    10.1016/J.MOLCEL.2017.06.007                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    7.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 7.900                          
REMARK   3   NUMBER OF PARTICLES               : 11767                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5VHP COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-APR-17.                  
REMARK 100 THE DEPOSITION ID IS D_1000227422.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : PROTEASOME REGULATORY PARTICLE    
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI ARCTICA             
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 50.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, A, B, D, E, F, C, f                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ALA A   283                                                      
REMARK 465     ARG A   284                                                      
REMARK 465     PHE A   285                                                      
REMARK 465     ASP A   286                                                      
REMARK 465     ASP A   287                                                      
REMARK 465     GLY A   288                                                      
REMARK 465     ALA A   289                                                      
REMARK 465     GLY A   290                                                      
REMARK 465     THR B   167                                                      
REMARK 465     ASP B   168                                                      
REMARK 465     PRO B   169                                                      
REMARK 465     LEU B   170                                                      
REMARK 465     VAL B   171                                                      
REMARK 465     THR B   172                                                      
REMARK 465     VAL B   173                                                      
REMARK 465     MET B   174                                                      
REMARK 465     LYS B   175                                                      
REMARK 465     VAL B   176                                                      
REMARK 465     GLU B   177                                                      
REMARK 465     LYS B   178                                                      
REMARK 465     ALA B   179                                                      
REMARK 465     PRO B   180                                                      
REMARK 465     GLN B   181                                                      
REMARK 465     GLU B   182                                                      
REMARK 465     THR B   183                                                      
REMARK 465     TYR B   184                                                      
REMARK 465     ALA B   185                                                      
REMARK 465     ASP B   186                                                      
REMARK 465     ILE B   187                                                      
REMARK 465     LYS B   293                                                      
REMARK 465     ARG B   294                                                      
REMARK 465     TYR B   295                                                      
REMARK 465     ASP B   296                                                      
REMARK 465     SER B   297                                                      
REMARK 465     ASN B   298                                                      
REMARK 465     SER B   299                                                      
REMARK 465     GLY B   300                                                      
REMARK 465     GLY B   301                                                      
REMARK 465     MET B   372                                                      
REMARK 465     THR B   373                                                      
REMARK 465     LEU B   374                                                      
REMARK 465     ALA B   375                                                      
REMARK 465     ASP B   376                                                      
REMARK 465     ASP B   377                                                      
REMARK 465     VAL B   378                                                      
REMARK 465     GLN B   431                                                      
REMARK 465     GLU B   432                                                      
REMARK 465     PRO D   145                                                      
REMARK 465     GLU D   146                                                      
REMARK 465     ALA D   147                                                      
REMARK 465     ASP D   148                                                      
REMARK 465     SER D   149                                                      
REMARK 465     SER D   150                                                      
REMARK 465     ILE D   151                                                      
REMARK 465     MET D   152                                                      
REMARK 465     MET D   153                                                      
REMARK 465     LEU D   154                                                      
REMARK 465     THR D   155                                                      
REMARK 465     SER D   156                                                      
REMARK 465     ASP D   157                                                      
REMARK 465     GLN D   158                                                      
REMARK 465     LYS D   159                                                      
REMARK 465     PRO D   160                                                      
REMARK 465     ASP D   161                                                      
REMARK 465     VAL D   162                                                      
REMARK 465     MET D   163                                                      
REMARK 465     TYR D   164                                                      
REMARK 465     ALA D   165                                                      
REMARK 465     ASP D   166                                                      
REMARK 465     ILE D   167                                                      
REMARK 465     GLY D   168                                                      
REMARK 465     GLY D   169                                                      
REMARK 465     GLY E   128                                                      
REMARK 465     ASN E   129                                                      
REMARK 465     VAL E   130                                                      
REMARK 465     SER E   131                                                      
REMARK 465     TYR E   132                                                      
REMARK 465     SER E   133                                                      
REMARK 465     GLU E   134                                                      
REMARK 465     ILE E   135                                                      
REMARK 465     GLY E   136                                                      
REMARK 465     GLY E   137                                                      
REMARK 465     LEU E   138                                                      
REMARK 465     SER E   139                                                      
REMARK 465     GLU E   140                                                      
REMARK 465     GLN E   141                                                      
REMARK 465     ILE E   142                                                      
REMARK 465     ARG E   143                                                      
REMARK 465     GLU E   144                                                      
REMARK 465     LEU E   145                                                      
REMARK 465     ARG E   146                                                      
REMARK 465     GLU E   147                                                      
REMARK 465     VAL E   148                                                      
REMARK 465     ILE E   149                                                      
REMARK 465     GLU E   150                                                      
REMARK 465     LEU E   151                                                      
REMARK 465     PRO E   152                                                      
REMARK 465     LEU E   153                                                      
REMARK 465     THR E   154                                                      
REMARK 465     ASN E   155                                                      
REMARK 465     PRO E   156                                                      
REMARK 465     GLU E   157                                                      
REMARK 465     LEU E   158                                                      
REMARK 465     PHE E   159                                                      
REMARK 465     GLN E   160                                                      
REMARK 465     ARG E   161                                                      
REMARK 465     VAL E   162                                                      
REMARK 465     GLY E   163                                                      
REMARK 465     ILE E   164                                                      
REMARK 465     ILE E   165                                                      
REMARK 465     PRO E   166                                                      
REMARK 465     PRO E   167                                                      
REMARK 465     ARG E   242                                                      
REMARK 465     PHE E   243                                                      
REMARK 465     SER E   244                                                      
REMARK 465     GLU E   245                                                      
REMARK 465     GLY E   246                                                      
REMARK 465     THR E   247                                                      
REMARK 465     SER E   248                                                      
REMARK 465     LEU E   384                                                      
REMARK 465     ASP E   385                                                      
REMARK 465     TYR E   386                                                      
REMARK 465     LYS E   387                                                      
REMARK 465     PRO E   388                                                      
REMARK 465     VAL E   389                                                      
REMARK 465     THR F   166                                                      
REMARK 465     GLU F   167                                                      
REMARK 465     TYR F   168                                                      
REMARK 465     ASP F   169                                                      
REMARK 465     SER F   170                                                      
REMARK 465     ARG F   171                                                      
REMARK 465     VAL F   172                                                      
REMARK 465     LYS F   173                                                      
REMARK 465     ALA F   174                                                      
REMARK 465     MET F   175                                                      
REMARK 465     GLU F   176                                                      
REMARK 465     VAL F   177                                                      
REMARK 465     ASP F   178                                                      
REMARK 465     GLU F   179                                                      
REMARK 465     ARG F   180                                                      
REMARK 465     PRO F   181                                                      
REMARK 465     THR F   182                                                      
REMARK 465     GLU F   183                                                      
REMARK 465     GLN F   184                                                      
REMARK 465     TYR F   185                                                      
REMARK 465     SER F   186                                                      
REMARK 465     ASP F   187                                                      
REMARK 465     ILE F   188                                                      
REMARK 465     GLY F   189                                                      
REMARK 465     GLY F   190                                                      
REMARK 465     ALA F   429                                                      
REMARK 465     LYS F   430                                                      
REMARK 465     LYS F   431                                                      
REMARK 465     LYS F   432                                                      
REMARK 465     LYS C   130                                                      
REMARK 465     VAL C   131                                                      
REMARK 465     ASP C   132                                                      
REMARK 465     PRO C   133                                                      
REMARK 465     LEU C   134                                                      
REMARK 465     VAL C   135                                                      
REMARK 465     SER C   136                                                      
REMARK 465     LEU C   137                                                      
REMARK 465     MET C   138                                                      
REMARK 465     MET C   139                                                      
REMARK 465     VAL C   140                                                      
REMARK 465     GLU C   141                                                      
REMARK 465     LYS C   142                                                      
REMARK 465     VAL C   143                                                      
REMARK 465     PRO C   144                                                      
REMARK 465     ASP C   145                                                      
REMARK 465     SER C   146                                                      
REMARK 465     THR C   147                                                      
REMARK 465     TYR C   148                                                      
REMARK 465     GLU C   149                                                      
REMARK 465     MET C   150                                                      
REMARK 465     ILE C   151                                                      
REMARK 465     GLY C   152                                                      
REMARK 465     GLY C   153                                                      
REMARK 465     ASN C   337                                                      
REMARK 465     LEU C   338                                                      
REMARK 465     THR C   339                                                      
REMARK 465     ARG C   340                                                      
REMARK 465     GLY C   341                                                      
REMARK 465     SER C   395                                                      
REMARK 465     GLY f   104                                                      
REMARK 465     LYS f   105                                                      
REMARK 465     LEU f   106                                                      
REMARK 465     LYS f   107                                                      
REMARK 465     GLU f   108                                                      
REMARK 465     ILE f   109                                                      
REMARK 465     TYR f   110                                                      
REMARK 465     GLU f   111                                                      
REMARK 465     ASN f   112                                                      
REMARK 465     MET f   113                                                      
REMARK 465     ALA f   114                                                      
REMARK 465     PRO f   115                                                      
REMARK 465     GLY f   116                                                      
REMARK 465     GLU f   117                                                      
REMARK 465     SER f   147                                                      
REMARK 465     GLN f   148                                                      
REMARK 465     GLU f   149                                                      
REMARK 465     GLU f   150                                                      
REMARK 465     LEU f   151                                                      
REMARK 465     ALA f   152                                                      
REMARK 465     SER f   153                                                      
REMARK 465     TRP f   154                                                      
REMARK 465     GLY f   155                                                      
REMARK 465     HIS f   156                                                      
REMARK 465     GLU f   157                                                      
REMARK 465     TYR f   158                                                      
REMARK 465     VAL f   159                                                      
REMARK 465     ARG f   160                                                      
REMARK 465     HIS f   161                                                      
REMARK 465     LEU f   162                                                      
REMARK 465     TYR f   194                                                      
REMARK 465     ASN f   195                                                      
REMARK 465     MET f   196                                                      
REMARK 465     ALA f   197                                                      
REMARK 465     HIS f   198                                                      
REMARK 465     ASN f   199                                                      
REMARK 465     ALA f   200                                                      
REMARK 465     GLU f   201                                                      
REMARK 465     HIS f   202                                                      
REMARK 465     GLU f   203                                                      
REMARK 465     ALA f   204                                                      
REMARK 465     CYS f   205                                                      
REMARK 465     ASP f   206                                                      
REMARK 465     VAL f   290                                                      
REMARK 465     GLN f   291                                                      
REMARK 465     LYS f   292                                                      
REMARK 465     GLN f   293                                                      
REMARK 465     MET f   294                                                      
REMARK 465     ALA f   295                                                      
REMARK 465     PHE f   296                                                      
REMARK 465     ALA f   383                                                      
REMARK 465     ALA f   384                                                      
REMARK 465     PHE f   385                                                      
REMARK 465     GLY f   386                                                      
REMARK 465     ALA f   490                                                      
REMARK 465     GLY f   491                                                      
REMARK 465     SER f   492                                                      
REMARK 465     SER f   700                                                      
REMARK 465     ASN f   701                                                      
REMARK 465     PRO f   702                                                      
REMARK 465     ARG f   703                                                      
REMARK 465     LEU f   704                                                      
REMARK 465     ASN f   705                                                      
REMARK 465     ILE f   706                                                      
REMARK 465     LEU f   707                                                      
REMARK 465     ASP f   708                                                      
REMARK 465     THR f   709                                                      
REMARK 465     LEU f   710                                                      
REMARK 465     SER f   711                                                      
REMARK 465     LYS f   712                                                      
REMARK 465     PHE f   713                                                      
REMARK 465     MET f   729                                                      
REMARK 465     GLY f   730                                                      
REMARK 465     MET f   731                                                      
REMARK 465     VAL f   732                                                      
REMARK 465     GLY f   733                                                      
REMARK 465     SER f   734                                                      
REMARK 465     GLY f   735                                                      
REMARK 465     THR f   736                                                      
REMARK 465     ASN f   737                                                      
REMARK 465     ASN f   738                                                      
REMARK 465     ASP f   755                                                      
REMARK 465     PRO f   756                                                      
REMARK 465     ASN f   757                                                      
REMARK 465     ASN f   758                                                      
REMARK 465     LEU f   759                                                      
REMARK 465     PHE f   760                                                      
REMARK 465     MET f   761                                                      
REMARK 465     VAL f   762                                                      
REMARK 465     ARG f   763                                                      
REMARK 465     LEU f   764                                                      
REMARK 465     ALA f   765                                                      
REMARK 465     GLN f   766                                                      
REMARK 465     GLY f   767                                                      
REMARK 465     LEU f   768                                                      
REMARK 465     THR f   769                                                      
REMARK 465     HIS f   770                                                      
REMARK 465     LEU f   771                                                      
REMARK 465     GLY f   772                                                      
REMARK 465     ASP f   805                                                      
REMARK 465     VAL f   806                                                      
REMARK 465     ARG f   807                                                      
REMARK 465     ASN f   808                                                      
REMARK 465     ILE f   809                                                      
REMARK 465     ILE f   810                                                      
REMARK 465     LEU f   811                                                      
REMARK 465     GLY f   812                                                      
REMARK 465     LYS f   813                                                      
REMARK 465     SER f   814                                                      
REMARK 465     HIS f   815                                                      
REMARK 465     TYR f   816                                                      
REMARK 465     VAL f   817                                                      
REMARK 465     LEU f   818                                                      
REMARK 465     TYR f   819                                                      
REMARK 465     GLY f   820                                                      
REMARK 465     LEU f   821                                                      
REMARK 465     VAL f   822                                                      
REMARK 465     ALA f   823                                                      
REMARK 465     ALA f   824                                                      
REMARK 465     MET f   825                                                      
REMARK 465     GLN f   826                                                      
REMARK 465     PRO f   827                                                      
REMARK 465     ARG f   828                                                      
REMARK 465     MET f   829                                                      
REMARK 465     LEU f   830                                                      
REMARK 465     VAL f   831                                                      
REMARK 465     THR f   832                                                      
REMARK 465     PHE f   833                                                      
REMARK 465     ASP f   834                                                      
REMARK 465     GLU f   835                                                      
REMARK 465     GLU f   836                                                      
REMARK 465     LEU f   837                                                      
REMARK 465     ARG f   838                                                      
REMARK 465     PRO f   839                                                      
REMARK 465     LEU f   840                                                      
REMARK 465     PRO f   841                                                      
REMARK 465     VAL f   842                                                      
REMARK 465     SER f   843                                                      
REMARK 465     VAL f   844                                                      
REMARK 465     ARG f   845                                                      
REMARK 465     VAL f   846                                                      
REMARK 465     GLY f   847                                                      
REMARK 465     GLN f   848                                                      
REMARK 465     ALA f   849                                                      
REMARK 465     VAL f   850                                                      
REMARK 465     ASP f   851                                                      
REMARK 465     VAL f   852                                                      
REMARK 465     VAL f   853                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    LYS A   415     OG   SER A   419              2.15            
REMARK 500   O    ASP f   347     OG1  THR f   351              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS A 169       73.17     53.72                                   
REMARK 500    ASP A 171     -142.79   -145.32                                   
REMARK 500    LYS A 210      -60.93    -91.58                                   
REMARK 500    THR A 220       31.14    -93.20                                   
REMARK 500    LYS A 222       -4.63     72.24                                   
REMARK 500    LYS A 267       37.58    -97.37                                   
REMARK 500    ASP A 325        0.87    -69.66                                   
REMARK 500    MET A 362      170.98    -57.00                                   
REMARK 500    LEU B 190       53.28    -92.25                                   
REMARK 500    LEU B 205       -7.32     71.58                                   
REMARK 500    HIS B 207       70.83     55.26                                   
REMARK 500    LYS B 217       71.89     41.97                                   
REMARK 500    PRO B 219       46.44    -89.09                                   
REMARK 500    ASP B 348      -62.49    -96.49                                   
REMARK 500    ASP B 357       -4.94     72.10                                   
REMARK 500    ASP D 171       -4.66     69.73                                   
REMARK 500    VAL D 181      -57.96   -123.03                                   
REMARK 500    LYS D 212       18.55     59.26                                   
REMARK 500    GLU D 242       -5.58     72.97                                   
REMARK 500    THR D 279       40.99   -104.10                                   
REMARK 500    ASP D 374       54.15     34.66                                   
REMARK 500    LEU E 191      -59.98   -124.79                                   
REMARK 500    ASP E 192       -8.46     65.43                                   
REMARK 500    CYS E 193       -7.45     64.72                                   
REMARK 500    SER E 211        7.70    -68.70                                   
REMARK 500    PHE E 267       54.49    -94.47                                   
REMARK 500    LEU E 285       30.83    -92.02                                   
REMARK 500    ASP E 286       77.14     53.72                                   
REMARK 500    ASP E 358       40.45     35.90                                   
REMARK 500    LYS F 245       -6.07     71.42                                   
REMARK 500    LYS F 294       78.24   -100.64                                   
REMARK 500    SER F 298       27.76   -140.38                                   
REMARK 500    PRO F 322       22.01    -78.92                                   
REMARK 500    LEU F 342       30.28    -98.26                                   
REMARK 500    MET F 356       76.37     53.42                                   
REMARK 500    PRO F 357       83.97    -68.41                                   
REMARK 500    PRO F 377       42.90    -82.90                                   
REMARK 500    TYR F 381       -6.71     71.40                                   
REMARK 500    LEU C 219       -9.11     72.50                                   
REMARK 500    LEU C 259       -3.37     68.96                                   
REMARK 500    PRO C 308       45.39    -76.10                                   
REMARK 500    PRO C 320       71.83    -68.86                                   
REMARK 500    MET C 351       83.00   -156.15                                   
REMARK 500    THR f  86      -62.25    -92.67                                   
REMARK 500    THR f  87      136.17   -170.30                                   
REMARK 500    SER f  88      149.44   -172.30                                   
REMARK 500    ARG f 100       75.21     53.82                                   
REMARK 500    LEU f 184        1.68     59.01                                   
REMARK 500    ARG f 261       68.87     62.20                                   
REMARK 500    VAL f 324      -69.27   -124.05                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      67 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8681   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8674   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8675   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8676   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8677   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8678   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8679   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8680   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8672   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8682   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8683   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8684   RELATED DB: EMDB                              
REMARK 900 RELATED ID: 5VGZ   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHF   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHH   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHI   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHJ   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHM   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHN   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHO   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHQ   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHR   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHS   RELATED DB: PDB                                   
DBREF  5VHP G    3   226  UNP    O75832   PSD10_HUMAN      3    226             
DBREF  5VHP A  159   424  UNP    P35998   PRS7_HUMAN     159    424             
DBREF  5VHP B  167   432  UNP    P62191   PRS4_HUMAN     167    432             
DBREF  5VHP D  145   406  UNP    P43686   PRS6B_HUMAN    114    375             
DBREF  5VHP E  128   389  UNP    P62333   PRS10_HUMAN    128    389             
DBREF  5VHP F  166   432  UNP    P17980   PRS6A_HUMAN    166    432             
DBREF  5VHP C  130   395  UNP    P62195   PRS8_HUMAN     130    395             
DBREF  5VHP f   70   853  UNP    Q13200   PSMD2_HUMAN     70    853             
SEQRES   1 G  224  GLY CYS VAL SER ASN LEU MET VAL CYS ASN LEU ALA TYR          
SEQRES   2 G  224  SER GLY LYS LEU GLU GLU LEU LYS GLU SER ILE LEU ALA          
SEQRES   3 G  224  ASP LYS SER LEU ALA THR ARG THR ASP GLN ASP SER ARG          
SEQRES   4 G  224  THR ALA LEU HIS TRP ALA CYS SER ALA GLY HIS THR GLU          
SEQRES   5 G  224  ILE VAL GLU PHE LEU LEU GLN LEU GLY VAL PRO VAL ASN          
SEQRES   6 G  224  ASP LYS ASP ASP ALA GLY TRP SER PRO LEU HIS ILE ALA          
SEQRES   7 G  224  ALA SER ALA GLY ARG ASP GLU ILE VAL LYS ALA LEU LEU          
SEQRES   8 G  224  GLY LYS GLY ALA GLN VAL ASN ALA VAL ASN GLN ASN GLY          
SEQRES   9 G  224  CYS THR PRO LEU HIS TYR ALA ALA SER LYS ASN ARG HIS          
SEQRES  10 G  224  GLU ILE ALA VAL MET LEU LEU GLU GLY GLY ALA ASN PRO          
SEQRES  11 G  224  ASP ALA LYS ASP HIS TYR GLU ALA THR ALA MET HIS ARG          
SEQRES  12 G  224  ALA ALA ALA LYS GLY ASN LEU LYS MET ILE HIS ILE LEU          
SEQRES  13 G  224  LEU TYR TYR LYS ALA SER THR ASN ILE GLN ASP THR GLU          
SEQRES  14 G  224  GLY ASN THR PRO LEU HIS LEU ALA CYS ASP GLU GLU ARG          
SEQRES  15 G  224  VAL GLU GLU ALA LYS LEU LEU VAL SER GLN GLY ALA SER          
SEQRES  16 G  224  ILE TYR ILE GLU ASN LYS GLU GLU LYS THR PRO LEU GLN          
SEQRES  17 G  224  VAL ALA LYS GLY GLY LEU GLY LEU ILE LEU LYS ARG MET          
SEQRES  18 G  224  VAL GLU GLY                                                  
SEQRES   1 A  266  PRO THR VAL THR MET MET GLN VAL GLU GLU LYS PRO ASP          
SEQRES   2 A  266  VAL THR TYR SER ASP VAL GLY GLY CYS LYS GLU GLN ILE          
SEQRES   3 A  266  GLU LYS LEU ARG GLU VAL VAL GLU THR PRO LEU LEU HIS          
SEQRES   4 A  266  PRO GLU ARG PHE VAL ASN LEU GLY ILE GLU PRO PRO LYS          
SEQRES   5 A  266  GLY VAL LEU LEU PHE GLY PRO PRO GLY THR GLY LYS THR          
SEQRES   6 A  266  LEU CYS ALA ARG ALA VAL ALA ASN ARG THR ASP ALA CYS          
SEQRES   7 A  266  PHE ILE ARG VAL ILE GLY SER GLU LEU VAL GLN LYS TYR          
SEQRES   8 A  266  VAL GLY GLU GLY ALA ARG MET VAL ARG GLU LEU PHE GLU          
SEQRES   9 A  266  MET ALA ARG THR LYS LYS ALA CYS LEU ILE PHE PHE ASP          
SEQRES  10 A  266  GLU ILE ASP ALA ILE GLY GLY ALA ARG PHE ASP ASP GLY          
SEQRES  11 A  266  ALA GLY GLY ASP ASN GLU VAL GLN ARG THR MET LEU GLU          
SEQRES  12 A  266  LEU ILE ASN GLN LEU ASP GLY PHE ASP PRO ARG GLY ASN          
SEQRES  13 A  266  ILE LYS VAL LEU MET ALA THR ASN ARG PRO ASP THR LEU          
SEQRES  14 A  266  ASP PRO ALA LEU MET ARG PRO GLY ARG LEU ASP ARG LYS          
SEQRES  15 A  266  ILE GLU PHE SER LEU PRO ASP LEU GLU GLY ARG THR HIS          
SEQRES  16 A  266  ILE PHE LYS ILE HIS ALA ARG SER MET SER VAL GLU ARG          
SEQRES  17 A  266  ASP ILE ARG PHE GLU LEU LEU ALA ARG LEU CYS PRO ASN          
SEQRES  18 A  266  SER THR GLY ALA GLU ILE ARG SER VAL CYS THR GLU ALA          
SEQRES  19 A  266  GLY MET PHE ALA ILE ARG ALA ARG ARG LYS ILE ALA THR          
SEQRES  20 A  266  GLU LYS ASP PHE LEU GLU ALA VAL ASN LYS VAL ILE LYS          
SEQRES  21 A  266  SER TYR ALA LYS PHE SER                                      
SEQRES   1 B  266  THR ASP PRO LEU VAL THR VAL MET LYS VAL GLU LYS ALA          
SEQRES   2 B  266  PRO GLN GLU THR TYR ALA ASP ILE GLY GLY LEU ASP ASN          
SEQRES   3 B  266  GLN ILE GLN GLU ILE LYS GLU SER VAL GLU LEU PRO LEU          
SEQRES   4 B  266  THR HIS PRO GLU TYR TYR GLU GLU MET GLY ILE LYS PRO          
SEQRES   5 B  266  PRO LYS GLY VAL ILE LEU TYR GLY PRO PRO GLY THR GLY          
SEQRES   6 B  266  LYS THR LEU LEU ALA LYS ALA VAL ALA ASN GLN THR SER          
SEQRES   7 B  266  ALA THR PHE LEU ARG VAL VAL GLY SER GLU LEU ILE GLN          
SEQRES   8 B  266  LYS TYR LEU GLY ASP GLY PRO LYS LEU VAL ARG GLU LEU          
SEQRES   9 B  266  PHE ARG VAL ALA GLU GLU HIS ALA PRO SER ILE VAL PHE          
SEQRES  10 B  266  ILE ASP GLU ILE ASP ALA ILE GLY THR LYS ARG TYR ASP          
SEQRES  11 B  266  SER ASN SER GLY GLY GLU ARG GLU ILE GLN ARG THR MET          
SEQRES  12 B  266  LEU GLU LEU LEU ASN GLN LEU ASP GLY PHE ASP SER ARG          
SEQRES  13 B  266  GLY ASP VAL LYS VAL ILE MET ALA THR ASN ARG ILE GLU          
SEQRES  14 B  266  THR LEU ASP PRO ALA LEU ILE ARG PRO GLY ARG ILE ASP          
SEQRES  15 B  266  ARG LYS ILE GLU PHE PRO LEU PRO ASP GLU LYS THR LYS          
SEQRES  16 B  266  LYS ARG ILE PHE GLN ILE HIS THR SER ARG MET THR LEU          
SEQRES  17 B  266  ALA ASP ASP VAL THR LEU ASP ASP LEU ILE MET ALA LYS          
SEQRES  18 B  266  ASP ASP LEU SER GLY ALA ASP ILE LYS ALA ILE CYS THR          
SEQRES  19 B  266  GLU ALA GLY LEU MET ALA LEU ARG GLU ARG ARG MET LYS          
SEQRES  20 B  266  VAL THR ASN GLU ASP PHE LYS LYS SER LYS GLU ASN VAL          
SEQRES  21 B  266  LEU TYR LYS LYS GLN GLU                                      
SEQRES   1 D  262  PRO GLU ALA ASP SER SER ILE MET MET LEU THR SER ASP          
SEQRES   2 D  262  GLN LYS PRO ASP VAL MET TYR ALA ASP ILE GLY GLY MET          
SEQRES   3 D  262  ASP ILE GLN LYS GLN GLU VAL ARG GLU ALA VAL GLU LEU          
SEQRES   4 D  262  PRO LEU THR HIS PHE GLU LEU TYR LYS GLN ILE GLY ILE          
SEQRES   5 D  262  ASP PRO PRO ARG GLY VAL LEU MET TYR GLY PRO PRO GLY          
SEQRES   6 D  262  CYS GLY LYS THR MET LEU ALA LYS ALA VAL ALA HIS HIS          
SEQRES   7 D  262  THR THR ALA ALA PHE ILE ARG VAL VAL GLY SER GLU PHE          
SEQRES   8 D  262  VAL GLN LYS TYR LEU GLY GLU GLY PRO ARG MET VAL ARG          
SEQRES   9 D  262  ASP VAL PHE ARG LEU ALA LYS GLU ASN ALA PRO ALA ILE          
SEQRES  10 D  262  ILE PHE ILE ASP GLU ILE ASP ALA ILE ALA THR LYS ARG          
SEQRES  11 D  262  PHE ASP ALA GLN THR GLY ALA ASP ARG GLU VAL GLN ARG          
SEQRES  12 D  262  ILE LEU LEU GLU LEU LEU ASN GLN MET ASP GLY PHE ASP          
SEQRES  13 D  262  GLN ASN VAL ASN VAL LYS VAL ILE MET ALA THR ASN ARG          
SEQRES  14 D  262  ALA ASP THR LEU ASP PRO ALA LEU LEU ARG PRO GLY ARG          
SEQRES  15 D  262  LEU ASP ARG LYS ILE GLU PHE PRO LEU PRO ASP ARG ARG          
SEQRES  16 D  262  GLN LYS ARG LEU ILE PHE SER THR ILE THR SER LYS MET          
SEQRES  17 D  262  ASN LEU SER GLU GLU VAL ASP LEU GLU ASP TYR VAL ALA          
SEQRES  18 D  262  ARG PRO ASP LYS ILE SER GLY ALA ASP ILE ASN SER ILE          
SEQRES  19 D  262  CYS GLN GLU SER GLY MET LEU ALA VAL ARG GLU ASN ARG          
SEQRES  20 D  262  TYR ILE VAL LEU ALA LYS ASP PHE GLU LYS ALA TYR LYS          
SEQRES  21 D  262  THR VAL                                                      
SEQRES   1 E  262  GLY ASN VAL SER TYR SER GLU ILE GLY GLY LEU SER GLU          
SEQRES   2 E  262  GLN ILE ARG GLU LEU ARG GLU VAL ILE GLU LEU PRO LEU          
SEQRES   3 E  262  THR ASN PRO GLU LEU PHE GLN ARG VAL GLY ILE ILE PRO          
SEQRES   4 E  262  PRO LYS GLY CYS LEU LEU TYR GLY PRO PRO GLY THR GLY          
SEQRES   5 E  262  LYS THR LEU LEU ALA ARG ALA VAL ALA SER GLN LEU ASP          
SEQRES   6 E  262  CYS ASN PHE LEU LYS VAL VAL SER SER SER ILE VAL ASP          
SEQRES   7 E  262  LYS TYR ILE GLY GLU SER ALA ARG LEU ILE ARG GLU MET          
SEQRES   8 E  262  PHE ASN TYR ALA ARG ASP HIS GLN PRO CYS ILE ILE PHE          
SEQRES   9 E  262  MET ASP GLU ILE ASP ALA ILE GLY GLY ARG ARG PHE SER          
SEQRES  10 E  262  GLU GLY THR SER ALA ASP ARG GLU ILE GLN ARG THR LEU          
SEQRES  11 E  262  MET GLU LEU LEU ASN GLN MET ASP GLY PHE ASP THR LEU          
SEQRES  12 E  262  HIS ARG VAL LYS MET ILE MET ALA THR ASN ARG PRO ASP          
SEQRES  13 E  262  THR LEU ASP PRO ALA LEU LEU ARG PRO GLY ARG LEU ASP          
SEQRES  14 E  262  ARG LYS ILE HIS ILE ASP LEU PRO ASN GLU GLN ALA ARG          
SEQRES  15 E  262  LEU ASP ILE LEU LYS ILE HIS ALA GLY PRO ILE THR LYS          
SEQRES  16 E  262  HIS GLY GLU ILE ASP TYR GLU ALA ILE VAL LYS LEU SER          
SEQRES  17 E  262  ASP GLY PHE ASN GLY ALA ASP LEU ARG ASN VAL CYS THR          
SEQRES  18 E  262  GLU ALA GLY MET PHE ALA ILE ARG ALA ASP HIS ASP PHE          
SEQRES  19 E  262  VAL VAL GLN GLU ASP PHE MET LYS ALA VAL ARG LYS VAL          
SEQRES  20 E  262  ALA ASP SER LYS LYS LEU GLU SER LYS LEU ASP TYR LYS          
SEQRES  21 E  262  PRO VAL                                                      
SEQRES   1 F  267  THR GLU TYR ASP SER ARG VAL LYS ALA MET GLU VAL ASP          
SEQRES   2 F  267  GLU ARG PRO THR GLU GLN TYR SER ASP ILE GLY GLY LEU          
SEQRES   3 F  267  ASP LYS GLN ILE GLN GLU LEU VAL GLU ALA ILE VAL LEU          
SEQRES   4 F  267  PRO MET ASN HIS LYS GLU LYS PHE GLU ASN LEU GLY ILE          
SEQRES   5 F  267  GLN PRO PRO LYS GLY VAL LEU MET TYR GLY PRO PRO GLY          
SEQRES   6 F  267  THR GLY LYS THR LEU LEU ALA ARG ALA CYS ALA ALA GLN          
SEQRES   7 F  267  THR LYS ALA THR PHE LEU LYS LEU ALA GLY PRO GLN LEU          
SEQRES   8 F  267  VAL GLN MET PHE ILE GLY ASP GLY ALA LYS LEU VAL ARG          
SEQRES   9 F  267  ASP ALA PHE ALA LEU ALA LYS GLU LYS ALA PRO SER ILE          
SEQRES  10 F  267  ILE PHE ILE ASP GLU LEU ASP ALA ILE GLY THR LYS ARG          
SEQRES  11 F  267  PHE ASP SER GLU LYS ALA GLY ASP ARG GLU VAL GLN ARG          
SEQRES  12 F  267  THR MET LEU GLU LEU LEU ASN GLN LEU ASP GLY PHE GLN          
SEQRES  13 F  267  PRO ASN THR GLN VAL LYS VAL ILE ALA ALA THR ASN ARG          
SEQRES  14 F  267  VAL ASP ILE LEU ASP PRO ALA LEU LEU ARG SER GLY ARG          
SEQRES  15 F  267  LEU ASP ARG LYS ILE GLU PHE PRO MET PRO ASN GLU GLU          
SEQRES  16 F  267  ALA ARG ALA ARG ILE MET GLN ILE HIS SER ARG LYS MET          
SEQRES  17 F  267  ASN VAL SER PRO ASP VAL ASN TYR GLU GLU LEU ALA ARG          
SEQRES  18 F  267  CYS THR ASP ASP PHE ASN GLY ALA GLN CYS LYS ALA VAL          
SEQRES  19 F  267  CYS VAL GLU ALA GLY MET ILE ALA LEU ARG ARG GLY ALA          
SEQRES  20 F  267  THR GLU LEU THR HIS GLU ASP TYR MET GLU GLY ILE LEU          
SEQRES  21 F  267  GLU VAL GLN ALA LYS LYS LYS                                  
SEQRES   1 C  266  LYS VAL ASP PRO LEU VAL SER LEU MET MET VAL GLU LYS          
SEQRES   2 C  266  VAL PRO ASP SER THR TYR GLU MET ILE GLY GLY LEU ASP          
SEQRES   3 C  266  LYS GLN ILE LYS GLU ILE LYS GLU VAL ILE GLU LEU PRO          
SEQRES   4 C  266  VAL LYS HIS PRO GLU LEU PHE GLU ALA LEU GLY ILE ALA          
SEQRES   5 C  266  GLN PRO LYS GLY VAL LEU LEU TYR GLY PRO PRO GLY THR          
SEQRES   6 C  266  GLY LYS THR LEU LEU ALA ARG ALA VAL ALA HIS HIS THR          
SEQRES   7 C  266  ASP CYS THR PHE ILE ARG VAL SER GLY SER GLU LEU VAL          
SEQRES   8 C  266  GLN LYS PHE ILE GLY GLU GLY ALA ARG MET VAL ARG GLU          
SEQRES   9 C  266  LEU PHE VAL MET ALA ARG GLU HIS ALA PRO SER ILE ILE          
SEQRES  10 C  266  PHE MET ASP GLU ILE ASP SER ILE GLY SER SER ARG LEU          
SEQRES  11 C  266  GLU GLY GLY SER GLY GLY ASP SER GLU VAL GLN ARG THR          
SEQRES  12 C  266  MET LEU GLU LEU LEU ASN GLN LEU ASP GLY PHE GLU ALA          
SEQRES  13 C  266  THR LYS ASN ILE LYS VAL ILE MET ALA THR ASN ARG ILE          
SEQRES  14 C  266  ASP ILE LEU ASP SER ALA LEU LEU ARG PRO GLY ARG ILE          
SEQRES  15 C  266  ASP ARG LYS ILE GLU PHE PRO PRO PRO ASN GLU GLU ALA          
SEQRES  16 C  266  ARG LEU ASP ILE LEU LYS ILE HIS SER ARG LYS MET ASN          
SEQRES  17 C  266  LEU THR ARG GLY ILE ASN LEU ARG LYS ILE ALA GLU LEU          
SEQRES  18 C  266  MET PRO GLY ALA SER GLY ALA GLU VAL LYS GLY VAL CYS          
SEQRES  19 C  266  THR GLU ALA GLY MET TYR ALA LEU ARG GLU ARG ARG VAL          
SEQRES  20 C  266  HIS VAL THR GLN GLU ASP PHE GLU MET ALA VAL ALA LYS          
SEQRES  21 C  266  VAL MET GLN LYS ASP SER                                      
SEQRES   1 f  784  LEU TYR ARG PRO ALA LEU GLU GLU LEU ARG ARG GLN ILE          
SEQRES   2 f  784  ARG SER SER THR THR SER MET THR SER VAL PRO LYS PRO          
SEQRES   3 f  784  LEU LYS PHE LEU ARG PRO HIS TYR GLY LYS LEU LYS GLU          
SEQRES   4 f  784  ILE TYR GLU ASN MET ALA PRO GLY GLU ASN LYS ARG PHE          
SEQRES   5 f  784  ALA ALA ASP ILE ILE SER VAL LEU ALA MET THR MET SER          
SEQRES   6 f  784  GLY GLU ARG GLU CYS LEU LYS TYR ARG LEU VAL GLY SER          
SEQRES   7 f  784  GLN GLU GLU LEU ALA SER TRP GLY HIS GLU TYR VAL ARG          
SEQRES   8 f  784  HIS LEU ALA GLY GLU VAL ALA LYS GLU TRP GLN GLU LEU          
SEQRES   9 f  784  ASP ASP ALA GLU LYS VAL GLN ARG GLU PRO LEU LEU THR          
SEQRES  10 f  784  LEU VAL LYS GLU ILE VAL PRO TYR ASN MET ALA HIS ASN          
SEQRES  11 f  784  ALA GLU HIS GLU ALA CYS ASP LEU LEU MET GLU ILE GLU          
SEQRES  12 f  784  GLN VAL ASP MET LEU GLU LYS ASP ILE ASP GLU ASN ALA          
SEQRES  13 f  784  TYR ALA LYS VAL CYS LEU TYR LEU THR SER CYS VAL ASN          
SEQRES  14 f  784  TYR VAL PRO GLU PRO GLU ASN SER ALA LEU LEU ARG CYS          
SEQRES  15 f  784  ALA LEU GLY VAL PHE ARG LYS PHE SER ARG PHE PRO GLU          
SEQRES  16 f  784  ALA LEU ARG LEU ALA LEU MET LEU ASN ASP MET GLU LEU          
SEQRES  17 f  784  VAL GLU ASP ILE PHE THR SER CYS LYS ASP VAL VAL VAL          
SEQRES  18 f  784  GLN LYS GLN MET ALA PHE MET LEU GLY ARG HIS GLY VAL          
SEQRES  19 f  784  PHE LEU GLU LEU SER GLU ASP VAL GLU GLU TYR GLU ASP          
SEQRES  20 f  784  LEU THR GLU ILE MET SER ASN VAL GLN LEU ASN SER ASN          
SEQRES  21 f  784  PHE LEU ALA LEU ALA ARG GLU LEU ASP ILE MET GLU PRO          
SEQRES  22 f  784  LYS VAL PRO ASP ASP ILE TYR LYS THR HIS LEU GLU ASN          
SEQRES  23 f  784  ASN ARG PHE GLY GLY SER GLY SER GLN VAL ASP SER ALA          
SEQRES  24 f  784  ARG MET ASN LEU ALA SER SER PHE VAL ASN GLY PHE VAL          
SEQRES  25 f  784  ASN ALA ALA PHE GLY GLN ASP LYS LEU LEU THR ASP ASP          
SEQRES  26 f  784  GLY ASN LYS TRP LEU TYR LYS ASN LYS ASP HIS GLY MET          
SEQRES  27 f  784  LEU SER ALA ALA ALA SER LEU GLY MET ILE LEU LEU TRP          
SEQRES  28 f  784  ASP VAL ASP GLY GLY LEU THR GLN ILE ASP LYS TYR LEU          
SEQRES  29 f  784  TYR SER SER GLU ASP TYR ILE LYS SER GLY ALA LEU LEU          
SEQRES  30 f  784  ALA CYS GLY ILE VAL ASN SER GLY VAL ARG ASN GLU CYS          
SEQRES  31 f  784  ASP PRO ALA LEU ALA LEU LEU SER ASP TYR VAL LEU HIS          
SEQRES  32 f  784  ASN SER ASN THR MET ARG LEU GLY SER ILE PHE GLY LEU          
SEQRES  33 f  784  GLY LEU ALA TYR ALA GLY SER ASN ARG GLU ASP VAL LEU          
SEQRES  34 f  784  THR LEU LEU LEU PRO VAL MET GLY ASP SER LYS SER SER          
SEQRES  35 f  784  MET GLU VAL ALA GLY VAL THR ALA LEU ALA CYS GLY MET          
SEQRES  36 f  784  ILE ALA VAL GLY SER CYS ASN GLY ASP VAL THR SER THR          
SEQRES  37 f  784  ILE LEU GLN THR ILE MET GLU LYS SER GLU THR GLU LEU          
SEQRES  38 f  784  LYS ASP THR TYR ALA ARG TRP LEU PRO LEU GLY LEU GLY          
SEQRES  39 f  784  LEU ASN HIS LEU GLY LYS GLY GLU ALA ILE GLU ALA ILE          
SEQRES  40 f  784  LEU ALA ALA LEU GLU VAL VAL SER GLU PRO PHE ARG SER          
SEQRES  41 f  784  PHE ALA ASN THR LEU VAL ASP VAL CYS ALA TYR ALA GLY          
SEQRES  42 f  784  SER GLY ASN VAL LEU LYS VAL GLN GLN LEU LEU HIS ILE          
SEQRES  43 f  784  CYS SER GLU HIS PHE ASP SER LYS GLU LYS GLU GLU ASP          
SEQRES  44 f  784  LYS ASP LYS LYS GLU LYS LYS ASP LYS ASP LYS LYS GLU          
SEQRES  45 f  784  ALA PRO ALA ASP MET GLY ALA HIS GLN GLY VAL ALA VAL          
SEQRES  46 f  784  LEU GLY ILE ALA LEU ILE ALA MET GLY GLU GLU ILE GLY          
SEQRES  47 f  784  ALA GLU MET ALA LEU ARG THR PHE GLY HIS LEU LEU ARG          
SEQRES  48 f  784  TYR GLY GLU PRO THR LEU ARG ARG ALA VAL PRO LEU ALA          
SEQRES  49 f  784  LEU ALA LEU ILE SER VAL SER ASN PRO ARG LEU ASN ILE          
SEQRES  50 f  784  LEU ASP THR LEU SER LYS PHE SER HIS ASP ALA ASP PRO          
SEQRES  51 f  784  GLU VAL SER TYR ASN SER ILE PHE ALA MET GLY MET VAL          
SEQRES  52 f  784  GLY SER GLY THR ASN ASN ALA ARG LEU ALA ALA MET LEU          
SEQRES  53 f  784  ARG GLN LEU ALA GLN TYR HIS ALA LYS ASP PRO ASN ASN          
SEQRES  54 f  784  LEU PHE MET VAL ARG LEU ALA GLN GLY LEU THR HIS LEU          
SEQRES  55 f  784  GLY LYS GLY THR LEU THR LEU CYS PRO TYR HIS SER ASP          
SEQRES  56 f  784  ARG GLN LEU MET SER GLN VAL ALA VAL ALA GLY LEU LEU          
SEQRES  57 f  784  THR VAL LEU VAL SER PHE LEU ASP VAL ARG ASN ILE ILE          
SEQRES  58 f  784  LEU GLY LYS SER HIS TYR VAL LEU TYR GLY LEU VAL ALA          
SEQRES  59 f  784  ALA MET GLN PRO ARG MET LEU VAL THR PHE ASP GLU GLU          
SEQRES  60 f  784  LEU ARG PRO LEU PRO VAL SER VAL ARG VAL GLY GLN ALA          
SEQRES  61 f  784  VAL ASP VAL VAL                                              
HELIX    1 AA1 LEU G    8  GLY G   17  1                                  10    
HELIX    2 AA2 LYS G   18  ASP G   29  1                                  12    
HELIX    3 AA3 LYS G   30  ARG G   35  5                                   6    
HELIX    4 AA4 THR G   42  GLY G   51  1                                  10    
HELIX    5 AA5 HIS G   52  GLY G   63  1                                  12    
HELIX    6 AA6 SER G   75  GLY G   84  1                                  10    
HELIX    7 AA7 ARG G   85  GLY G   96  1                                  12    
HELIX    8 AA8 THR G  108  LYS G  116  1                                   9    
HELIX    9 AA9 ARG G  118  GLY G  128  1                                  11    
HELIX   10 AB1 THR G  141  LYS G  149  1                                   9    
HELIX   11 AB2 ASN G  151  TYR G  161  1                                  11    
HELIX   12 AB3 THR G  174  GLU G  182  1                                   9    
HELIX   13 AB4 ARG G  184  GLN G  194  1                                  11    
HELIX   14 AB5 THR G  207  ALA G  212  1                                   6    
HELIX   15 AB6 GLY G  215  GLY G  226  1                                  12    
HELIX   16 AB7 THR A  160  MET A  164  1                                   5    
HELIX   17 AB8 THR A  173  VAL A  177  5                                   5    
HELIX   18 AB9 GLU A  182  LEU A  187  1                                   6    
HELIX   19 AC1 GLU A  192  HIS A  197  1                                   6    
HELIX   20 AC2 HIS A  197  GLY A  205  1                                   9    
HELIX   21 AC3 LYS A  222  ASN A  231  1                                  10    
HELIX   22 AC4 GLY A  251  LYS A  267  1                                  17    
HELIX   23 AC5 ILE A  277  ILE A  280  5                                   4    
HELIX   24 AC6 ASP A  292  GLY A  308  1                                  17    
HELIX   25 AC7 THR A  326  ARG A  333  1                                   8    
HELIX   26 AC8 GLY A  350  HIS A  358  1                                   9    
HELIX   27 AC9 ALA A  359  SER A  361  5                                   3    
HELIX   28 AD1 ARG A  369  ARG A  375  1                                   7    
HELIX   29 AD2 THR A  381  ARG A  398  1                                  18    
HELIX   30 AD3 PHE A  409  LYS A  422  1                                  14    
HELIX   31 AD4 LEU B  190  GLU B  202  1                                  13    
HELIX   32 AD5 HIS B  207  GLY B  215  1                                   9    
HELIX   33 AD6 GLY B  231  ALA B  238  1                                   8    
HELIX   34 AD7 VAL B  239  THR B  243  5                                   5    
HELIX   35 AD8 SER B  253  LYS B  258  1                                   6    
HELIX   36 AD9 PRO B  264  GLU B  276  1                                  13    
HELIX   37 AE1 ARG B  303  ASP B  317  1                                  15    
HELIX   38 AE2 ARG B  333  LEU B  337  5                                   5    
HELIX   39 AE3 ASP B  338  ILE B  342  5                                   5    
HELIX   40 AE4 LYS B  359  ARG B  371  1                                  13    
HELIX   41 AE5 LEU B  380  LYS B  387  1                                   8    
HELIX   42 AE6 SER B  391  ARG B  410  1                                  20    
HELIX   43 AE7 THR B  415  LYS B  430  1                                  16    
HELIX   44 AE8 ILE D  172  GLU D  182  1                                  11    
HELIX   45 AE9 GLU D  189  ILE D  194  1                                   6    
HELIX   46 AF1 THR D  213  THR D  223  1                                  11    
HELIX   47 AF2 GLU D  242  LYS D  255  1                                  14    
HELIX   48 AF3 THR D  279  GLY D  298  1                                  20    
HELIX   49 AF4 ASP D  337  SER D  350  1                                  14    
HELIX   50 AF5 GLU D  361  ILE D  370  1                                  10    
HELIX   51 AF6 ASP D  374  LEU D  385  1                                  12    
HELIX   52 AF7 LEU D  395  VAL D  406  1                                  12    
HELIX   53 AF8 GLY E  179  LEU E  191  1                                  13    
HELIX   54 AF9 SER E  211  HIS E  225  1                                  15    
HELIX   55 AG1 ASP E  250  ASP E  265  1                                  16    
HELIX   56 AG2 ASN E  305  ALA E  317  1                                  13    
HELIX   57 AG3 ASP E  327  SER E  335  1                                   9    
HELIX   58 AG4 ASN E  339  ILE E  355  1                                  17    
HELIX   59 AG5 ARG E  356  ASP E  358  5                                   3    
HELIX   60 AG6 GLN E  364  GLU E  381  1                                  18    
HELIX   61 AG7 ASP F  192  HIS F  208  1                                  17    
HELIX   62 AG8 HIS F  208  LEU F  215  1                                   8    
HELIX   63 AG9 GLY F  232  THR F  244  1                                  13    
HELIX   64 AH1 GLY F  253  VAL F  257  5                                   5    
HELIX   65 AH2 GLY F  262  LYS F  278  1                                  17    
HELIX   66 AH3 GLY F  302  GLY F  319  1                                  18    
HELIX   67 AH4 ASN F  358  SER F  370  1                                  13    
HELIX   68 AH5 TYR F  381  THR F  388  1                                   8    
HELIX   69 AH6 ASN F  392  GLY F  411  1                                  20    
HELIX   70 AH7 GLU F  418  GLN F  428  1                                  11    
HELIX   71 AH8 ASP C  155  GLU C  160  1                                   6    
HELIX   72 AH9 GLU C  173  GLY C  179  1                                   7    
HELIX   73 AI1 THR C  197  THR C  207  1                                  11    
HELIX   74 AI2 VAL C  231  HIS C  241  1                                  11    
HELIX   75 AI3 GLY C  261  ASP C  281  1                                  21    
HELIX   76 AI4 ILE C  298  ARG C  307  1                                  10    
HELIX   77 AI5 ASN C  321  HIS C  332  1                                  12    
HELIX   78 AI6 LEU C  344  LEU C  350  1                                   7    
HELIX   79 AI7 ALA C  357  GLU C  365  1                                   9    
HELIX   80 AI8 ALA C  366  GLU C  373  1                                   8    
HELIX   81 AI9 THR C  379  ASP C  394  1                                  16    
HELIX   82 AJ1 TYR f   71  THR f   87  1                                  17    
HELIX   83 AJ2 PRO f   93  PHE f   98  1                                   6    
HELIX   84 AJ3 LYS f  119  VAL f  145  1                                  27    
HELIX   85 AJ4 GLY f  164  ARG f  181  1                                  18    
HELIX   86 AJ5 LEU f  185  GLU f  190  1                                   6    
HELIX   87 AJ6 LEU f  208  LEU f  217  1                                  10    
HELIX   88 AJ7 ILE f  221  TYR f  239  1                                  19    
HELIX   89 AJ8 PRO f  241  PHE f  259  1                                  19    
HELIX   90 AJ9 ARG f  261  ASN f  273  1                                  13    
HELIX   91 AK1 ASP f  274  VAL f  288  1                                  15    
HELIX   92 AK2 LEU f  298  GLU f  309  1                                  12    
HELIX   93 AK3 ASP f  310  SER f  322  1                                  13    
HELIX   94 AK4 SER f  328  ALA f  334  1                                   7    
HELIX   95 AK5 PRO f  342  LYS f  350  1                                   9    
HELIX   96 AK6 ASN f  355  SER f  361  1                                   7    
HELIX   97 AK7 ARG f  369  PHE f  380  1                                  12    
HELIX   98 AK8 LYS f  403  ILE f  417  1                                  15    
HELIX   99 AK9 ASP f  421  ASP f  430  1                                  10    
HELIX  100 AL1 LYS f  431  LEU f  433  5                                   3    
HELIX  101 AL2 GLU f  437  ASN f  452  1                                  16    
HELIX  102 AL3 GLU f  458  ALA f  464  1                                   7    
HELIX  103 AL4 LEU f  465  SER f  467  5                                   3    
HELIX  104 AL5 HIS f  472  TYR f  489  1                                  18    
HELIX  105 AL6 GLU f  495  LEU f  501  1                                   7    
HELIX  106 AL7 LEU f  501  SER f  508  1                                   8    
HELIX  107 AL8 SER f  511  ALA f  526  1                                  16    
HELIX  108 AL9 THR f  535  GLU f  544  1                                  10    
HELIX  109 AM1 ASP f  552  LEU f  567  1                                  16    
HELIX  110 AM2 ILE f  573  VAL f  582  1                                  10    
HELIX  111 AM3 GLU f  585  ALA f  599  1                                  15    
HELIX  112 AM4 VAL f  606  CYS f  616  1                                  11    
HELIX  113 AM5 SER f  622  ASP f  628  1                                   7    
HELIX  114 AM6 ASP f  630  LYS f  635  1                                   6    
HELIX  115 AM7 GLY f  651  GLY f  663  1                                  13    
HELIX  116 AM8 ALA f  668  ARG f  680  1                                  13    
HELIX  117 AM9 GLU f  683  ILE f  697  1                                  15    
HELIX  118 AN1 ALA f  717  ALA f  728  1                                  12    
HELIX  119 AN2 ARG f  740  ALA f  753  1                                  14    
HELIX  120 AN3 GLY f  774  CYS f  779  1                                   6    
HELIX  121 AN4 SER f  783  LEU f  787  5                                   5    
HELIX  122 AN5 VAL f  793  THR f  798  1                                   6    
SHEET    1 AA1 5 ILE A 238  ILE A 241  0                                        
SHEET    2 AA1 5 ILE A 272  ASP A 275  1  O  PHE A 273   N  VAL A 240           
SHEET    3 AA1 5 LEU A 318  ALA A 320  1  O  LEU A 318   N  PHE A 274           
SHEET    4 AA1 5 VAL A 212  PHE A 215  1  N  LEU A 214   O  MET A 319           
SHEET    5 AA1 5 LYS A 340  GLU A 342  1  O  ILE A 341   N  LEU A 213           
SHEET    1 AA2 4 ILE B 223  TYR B 225  0                                        
SHEET    2 AA2 4 LYS B 326  THR B 331  1  O  MET B 329   N  LEU B 224           
SHEET    3 AA2 4 SER B 280  ASP B 285  1  N  VAL B 282   O  ILE B 328           
SHEET    4 AA2 4 THR B 246  VAL B 251  1  N  VAL B 250   O  PHE B 283           
SHEET    1 AA3 2 VAL D 202  LEU D 203  0                                        
SHEET    2 AA3 2 ARG D 329  LYS D 330  1  O  ARG D 329   N  LEU D 203           
SHEET    1 AA4 3 ARG D 229  VAL D 231  0                                        
SHEET    2 AA4 3 ILE D 261  ASP D 265  1  O  PHE D 263   N  VAL D 230           
SHEET    3 AA4 3 LYS D 306  ALA D 310  1  O  ILE D 308   N  ILE D 262           
SHEET    1 AA5 5 LYS E 197  VAL E 199  0                                        
SHEET    2 AA5 5 ILE E 229  ASP E 233  1  O  PHE E 231   N  VAL E 198           
SHEET    3 AA5 5 LYS E 274  THR E 279  1  O  ILE E 276   N  ILE E 230           
SHEET    4 AA5 5 CYS E 170  TYR E 173  1  N  CYS E 170   O  MET E 277           
SHEET    5 AA5 5 ARG E 297  HIS E 300  1  O  ARG E 297   N  LEU E 171           
SHEET    1 AA6 2 GLY F 222  LEU F 224  0                                        
SHEET    2 AA6 2 LEU F 348  LYS F 351  1  O  ASP F 349   N  GLY F 222           
SHEET    1 AA7 2 ILE F 282  ASP F 286  0                                        
SHEET    2 AA7 2 LYS F 327  ALA F 331  1  O  ILE F 329   N  ILE F 285           
SHEET    1 AA8 5 THR C 210  PHE C 211  0                                        
SHEET    2 AA8 5 SER C 244  PHE C 247  1  O  ILE C 245   N  THR C 210           
SHEET    3 AA8 5 ILE C 289  THR C 295  1  O  ILE C 292   N  ILE C 246           
SHEET    4 AA8 5 GLY C 185  TYR C 189  1  N  LEU C 188   O  MET C 293           
SHEET    5 AA8 5 ARG C 313  GLU C 316  1  O  ARG C 313   N  LEU C 187           
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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