GenomeNet

Database: PDB
Entry: 5VHW
LinkDB: 5VHW
Original site: 5VHW 
HEADER    TRANSPORT PROTEIN                       13-APR-17   5VHW              
TITLE     GLUA2-0XGSG1L BOUND TO ZK                                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: GLUTAMATE RECEPTOR 2,GERM CELL-SPECIFIC GENE 1-LIKE        
COMPND   3 PROTEIN;                                                             
COMPND   4 CHAIN: A, B, C, D;                                                   
COMPND   5 SYNONYM: GLUR-2,AMPA-SELECTIVE GLUTAMATE RECEPTOR 2,GLUR-B,GLUR-K2,  
COMPND   6 GLUTAMATE RECEPTOR IONOTROPIC,AMPA 2,GLUA2,GSG1-LIKE PROTEIN;        
COMPND   7 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE   3 ORGANISM_COMMON: RAT;                                                
SOURCE   4 ORGANISM_TAXID: 10116;                                               
SOURCE   5 GENE: GRIA2, GLUR2, GSG1L;                                           
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   8 EXPRESSION_SYSTEM_CELL_LINE: HEK-293S;                               
SOURCE   9 EXPRESSION_SYSTEM_ATCC_NUMBER: CRL-3022                              
KEYWDS    ION CHANNEL, TRANSPORT PROTEIN                                        
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    E.C.TWOMEY,M.V.YELSHANSKAYA,R.A.GRASSUCCI,J.FRANK,A.I.SOBOLEVSKY      
REVDAT   4   08-NOV-17 5VHW    1       REMARK                                   
REVDAT   3   20-SEP-17 5VHW    1       REMARK                                   
REVDAT   2   17-MAY-17 5VHW    1       JRNL                                     
REVDAT   1   03-MAY-17 5VHW    0                                                
JRNL        AUTH   E.C.TWOMEY,M.V.YELSHANSKAYA,R.A.GRASSUCCI,J.FRANK,           
JRNL        AUTH 2 A.I.SOBOLEVSKY                                               
JRNL        TITL   STRUCTURAL BASES OF DESENSITIZATION IN AMPA                  
JRNL        TITL 2 RECEPTOR-AUXILIARY SUBUNIT COMPLEXES.                        
JRNL        REF    NEURON                        V.  94   569 2017              
JRNL        REFN                   ISSN 1097-4199                               
JRNL        PMID   28472657                                                     
JRNL        DOI    10.1016/J.NEURON.2017.04.025                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    7.80 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : FOURIER SPACE                             
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 7.800                          
REMARK   3   NUMBER OF PARTICLES               : 14372                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5VHW COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 14-APR-17.                  
REMARK 100 THE DEPOSITION ID IS D_1000227445.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : GLUA2-0XGSG1L CRYO-EM DENSITY     
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 5.00                              
REMARK 245   SAMPLE SUPPORT DETAILS         : GOLD-GOLD GRIDS, HYDROGEN AND     
REMARK 245                                    OXYGEN GLOW DISCHARGE (20S, 10    
REMARK 245                                    WATTS, 6.4 SCCM H2, 27.5 SCCM     
REMARK 245                                    O2)                               
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 80.00                          
REMARK 245   ILLUMINATION MODE                 : SPOT SCAN                      
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ARG A   545                                                      
REMARK 465     PHE A   546                                                      
REMARK 465     SER A   547                                                      
REMARK 465     PRO A   548                                                      
REMARK 465     TYR A   549                                                      
REMARK 465     GLU A   550                                                      
REMARK 465     TRP A   551                                                      
REMARK 465     HIS A   552                                                      
REMARK 465     THR A   553                                                      
REMARK 465     GLU A   554                                                      
REMARK 465     GLU A   555                                                      
REMARK 465     PHE A   556                                                      
REMARK 465     GLU A   557                                                      
REMARK 465     ASP A   558                                                      
REMARK 465     GLY A   559                                                      
REMARK 465     ARG A   560                                                      
REMARK 465     GLU A   561                                                      
REMARK 465     THR A   562                                                      
REMARK 465     GLN A   563                                                      
REMARK 465     SER A   564                                                      
REMARK 465     SER A   565                                                      
REMARK 465     GLU A   566                                                      
REMARK 465     SER A   567                                                      
REMARK 465     THR A   568                                                      
REMARK 465     ASN A   569                                                      
REMARK 465     GLU A   570                                                      
REMARK 465     PHE A   571                                                      
REMARK 465     GLY A   572                                                      
REMARK 465     GLU A   821                                                      
REMARK 465     ALA A   822                                                      
REMARK 465     LYS A   823                                                      
REMARK 465     ARG A   824                                                      
REMARK 465     MET A   825                                                      
REMARK 465     LYS A   826                                                      
REMARK 465     GLY A   827                                                      
REMARK 465     THR A   828                                                      
REMARK 465     GLY A   829                                                      
REMARK 465     LYS A   830                                                      
REMARK 465     THR A   831                                                      
REMARK 465     SER A   832                                                      
REMARK 465     ARG A   833                                                      
REMARK 465     ARG A   834                                                      
REMARK 465     GLY A   835                                                      
REMARK 465     ARG A   836                                                      
REMARK 465     ALA A   837                                                      
REMARK 465     LEU A   838                                                      
REMARK 465     LEU A   839                                                      
REMARK 465     ALA A   840                                                      
REMARK 465     VAL A   841                                                      
REMARK 465     ALA A   842                                                      
REMARK 465     LEU A   843                                                      
REMARK 465     ASN A   844                                                      
REMARK 465     LEU A   845                                                      
REMARK 465     LEU A   846                                                      
REMARK 465     ALA A   847                                                      
REMARK 465     LEU A   848                                                      
REMARK 465     LEU A   849                                                      
REMARK 465     PHE A   850                                                      
REMARK 465     ALA A   851                                                      
REMARK 465     THR A   852                                                      
REMARK 465     THR A   853                                                      
REMARK 465     ALA A   854                                                      
REMARK 465     PHE A   855                                                      
REMARK 465     LEU A   856                                                      
REMARK 465     THR A   857                                                      
REMARK 465     THR A   858                                                      
REMARK 465     TYR A   859                                                      
REMARK 465     TRP A   860                                                      
REMARK 465     CYS A   861                                                      
REMARK 465     GLN A   862                                                      
REMARK 465     GLY A   863                                                      
REMARK 465     THR A   864                                                      
REMARK 465     GLN A   865                                                      
REMARK 465     ARG A   866                                                      
REMARK 465     VAL A   867                                                      
REMARK 465     PRO A   868                                                      
REMARK 465     LYS A   869                                                      
REMARK 465     PRO A   870                                                      
REMARK 465     GLY A   871                                                      
REMARK 465     CYS A   872                                                      
REMARK 465     GLY A   873                                                      
REMARK 465     GLN A   874                                                      
REMARK 465     GLY A   875                                                      
REMARK 465     GLY A   876                                                      
REMARK 465     GLY A   877                                                      
REMARK 465     ALA A   878                                                      
REMARK 465     ASN A   879                                                      
REMARK 465     CYS A   880                                                      
REMARK 465     PRO A   881                                                      
REMARK 465     ASN A   882                                                      
REMARK 465     SER A   883                                                      
REMARK 465     GLY A   884                                                      
REMARK 465     ALA A   885                                                      
REMARK 465     ASN A   886                                                      
REMARK 465     ALA A   887                                                      
REMARK 465     THR A   888                                                      
REMARK 465     ALA A   889                                                      
REMARK 465     ASN A   890                                                      
REMARK 465     SER A   891                                                      
REMARK 465     THR A   892                                                      
REMARK 465     ALA A   893                                                      
REMARK 465     ALA A   894                                                      
REMARK 465     PRO A   895                                                      
REMARK 465     VAL A   896                                                      
REMARK 465     ALA A   897                                                      
REMARK 465     ALA A   898                                                      
REMARK 465     SER A   899                                                      
REMARK 465     PRO A   900                                                      
REMARK 465     ALA A   901                                                      
REMARK 465     GLY A   902                                                      
REMARK 465     ALA A   903                                                      
REMARK 465     PRO A   904                                                      
REMARK 465     TYR A   905                                                      
REMARK 465     SER A   906                                                      
REMARK 465     TRP A   907                                                      
REMARK 465     GLU A   908                                                      
REMARK 465     ALA A   909                                                      
REMARK 465     GLY A   910                                                      
REMARK 465     ASP A   911                                                      
REMARK 465     GLU A   912                                                      
REMARK 465     ARG A   913                                                      
REMARK 465     PHE A   914                                                      
REMARK 465     GLN A   915                                                      
REMARK 465     LEU A   916                                                      
REMARK 465     ARG A   917                                                      
REMARK 465     ARG A   918                                                      
REMARK 465     PHE A   919                                                      
REMARK 465     HIS A   920                                                      
REMARK 465     THR A   921                                                      
REMARK 465     GLY A   922                                                      
REMARK 465     ILE A   923                                                      
REMARK 465     TRP A   924                                                      
REMARK 465     TYR A   925                                                      
REMARK 465     SER A   926                                                      
REMARK 465     CYS A   927                                                      
REMARK 465     GLU A   928                                                      
REMARK 465     GLU A   929                                                      
REMARK 465     GLU A   930                                                      
REMARK 465     LEU A   931                                                      
REMARK 465     GLY A   932                                                      
REMARK 465     GLY A   933                                                      
REMARK 465     PRO A   934                                                      
REMARK 465     GLY A   935                                                      
REMARK 465     GLU A   936                                                      
REMARK 465     LYS A   937                                                      
REMARK 465     CYS A   938                                                      
REMARK 465     ARG A   939                                                      
REMARK 465     SER A   940                                                      
REMARK 465     PHE A   941                                                      
REMARK 465     ILE A   942                                                      
REMARK 465     ASP A   943                                                      
REMARK 465     LEU A   944                                                      
REMARK 465     ALA A   945                                                      
REMARK 465     PRO A   946                                                      
REMARK 465     ALA A   947                                                      
REMARK 465     SER A   948                                                      
REMARK 465     GLU A   949                                                      
REMARK 465     LYS A   950                                                      
REMARK 465     GLY A   951                                                      
REMARK 465     VAL A   952                                                      
REMARK 465     LEU A   953                                                      
REMARK 465     TRP A   954                                                      
REMARK 465     LEU A   955                                                      
REMARK 465     SER A   956                                                      
REMARK 465     VAL A   957                                                      
REMARK 465     VAL A   958                                                      
REMARK 465     SER A   959                                                      
REMARK 465     GLU A   960                                                      
REMARK 465     VAL A   961                                                      
REMARK 465     LEU A   962                                                      
REMARK 465     TYR A   963                                                      
REMARK 465     ILE A   964                                                      
REMARK 465     LEU A   965                                                      
REMARK 465     LEU A   966                                                      
REMARK 465     LEU A   967                                                      
REMARK 465     VAL A   968                                                      
REMARK 465     VAL A   969                                                      
REMARK 465     GLY A   970                                                      
REMARK 465     PHE A   971                                                      
REMARK 465     SER A   972                                                      
REMARK 465     LEU A   973                                                      
REMARK 465     MET A   974                                                      
REMARK 465     CYS A   975                                                      
REMARK 465     LEU A   976                                                      
REMARK 465     GLU A   977                                                      
REMARK 465     LEU A   978                                                      
REMARK 465     LEU A   979                                                      
REMARK 465     HIS A   980                                                      
REMARK 465     SER A   981                                                      
REMARK 465     SER A   982                                                      
REMARK 465     SER A   983                                                      
REMARK 465     VAL A   984                                                      
REMARK 465     ILE A   985                                                      
REMARK 465     ASP A   986                                                      
REMARK 465     GLY A   987                                                      
REMARK 465     LEU A   988                                                      
REMARK 465     LYS A   989                                                      
REMARK 465     LEU A   990                                                      
REMARK 465     ASN A   991                                                      
REMARK 465     ALA A   992                                                      
REMARK 465     PHE A   993                                                      
REMARK 465     ALA A   994                                                      
REMARK 465     ALA A   995                                                      
REMARK 465     VAL A   996                                                      
REMARK 465     PHE A   997                                                      
REMARK 465     THR A   998                                                      
REMARK 465     VAL A   999                                                      
REMARK 465     LEU A  1000                                                      
REMARK 465     SER A  1001                                                      
REMARK 465     GLY A  1002                                                      
REMARK 465     LEU A  1003                                                      
REMARK 465     LEU A  1004                                                      
REMARK 465     GLY A  1005                                                      
REMARK 465     MET A  1006                                                      
REMARK 465     VAL A  1007                                                      
REMARK 465     ALA A  1008                                                      
REMARK 465     HIS A  1009                                                      
REMARK 465     MET A  1010                                                      
REMARK 465     MET A  1011                                                      
REMARK 465     TYR A  1012                                                      
REMARK 465     THR A  1013                                                      
REMARK 465     GLN A  1014                                                      
REMARK 465     VAL A  1015                                                      
REMARK 465     PHE A  1016                                                      
REMARK 465     GLN A  1017                                                      
REMARK 465     VAL A  1018                                                      
REMARK 465     THR A  1019                                                      
REMARK 465     VAL A  1020                                                      
REMARK 465     SER A  1021                                                      
REMARK 465     LEU A  1022                                                      
REMARK 465     GLY A  1023                                                      
REMARK 465     PRO A  1024                                                      
REMARK 465     GLU A  1025                                                      
REMARK 465     ASP A  1026                                                      
REMARK 465     TRP A  1027                                                      
REMARK 465     ARG A  1028                                                      
REMARK 465     PRO A  1029                                                      
REMARK 465     HIS A  1030                                                      
REMARK 465     SER A  1031                                                      
REMARK 465     TRP A  1032                                                      
REMARK 465     ASP A  1033                                                      
REMARK 465     TYR A  1034                                                      
REMARK 465     GLY A  1035                                                      
REMARK 465     TRP A  1036                                                      
REMARK 465     SER A  1037                                                      
REMARK 465     PHE A  1038                                                      
REMARK 465     CYS A  1039                                                      
REMARK 465     LEU A  1040                                                      
REMARK 465     ALA A  1041                                                      
REMARK 465     TRP A  1042                                                      
REMARK 465     GLY A  1043                                                      
REMARK 465     SER A  1044                                                      
REMARK 465     PHE A  1045                                                      
REMARK 465     THR A  1046                                                      
REMARK 465     CYS A  1047                                                      
REMARK 465     CYS A  1048                                                      
REMARK 465     MET A  1049                                                      
REMARK 465     ALA A  1050                                                      
REMARK 465     ALA A  1051                                                      
REMARK 465     SER A  1052                                                      
REMARK 465     VAL A  1053                                                      
REMARK 465     THR A  1054                                                      
REMARK 465     THR A  1055                                                      
REMARK 465     LEU A  1056                                                      
REMARK 465     ASN A  1057                                                      
REMARK 465     SER A  1058                                                      
REMARK 465     TYR A  1059                                                      
REMARK 465     THR A  1060                                                      
REMARK 465     LYS A  1061                                                      
REMARK 465     THR A  1062                                                      
REMARK 465     VAL A  1063                                                      
REMARK 465     ILE A  1064                                                      
REMARK 465     GLU A  1065                                                      
REMARK 465     PHE A  1066                                                      
REMARK 465     ARG B   545                                                      
REMARK 465     PHE B   546                                                      
REMARK 465     SER B   547                                                      
REMARK 465     PRO B   548                                                      
REMARK 465     TYR B   549                                                      
REMARK 465     GLU B   550                                                      
REMARK 465     TRP B   551                                                      
REMARK 465     HIS B   552                                                      
REMARK 465     THR B   553                                                      
REMARK 465     GLU B   554                                                      
REMARK 465     GLU B   555                                                      
REMARK 465     PHE B   556                                                      
REMARK 465     GLU B   557                                                      
REMARK 465     ASP B   558                                                      
REMARK 465     GLY B   559                                                      
REMARK 465     ARG B   560                                                      
REMARK 465     GLU B   561                                                      
REMARK 465     THR B   562                                                      
REMARK 465     GLN B   563                                                      
REMARK 465     SER B   564                                                      
REMARK 465     SER B   565                                                      
REMARK 465     GLU B   566                                                      
REMARK 465     SER B   567                                                      
REMARK 465     THR B   568                                                      
REMARK 465     ASN B   569                                                      
REMARK 465     GLU B   570                                                      
REMARK 465     PHE B   571                                                      
REMARK 465     GLY B   572                                                      
REMARK 465     SER B   818                                                      
REMARK 465     ARG B   819                                                      
REMARK 465     ALA B   820                                                      
REMARK 465     GLU B   821                                                      
REMARK 465     ALA B   822                                                      
REMARK 465     LYS B   823                                                      
REMARK 465     ARG B   824                                                      
REMARK 465     MET B   825                                                      
REMARK 465     LYS B   826                                                      
REMARK 465     GLY B   827                                                      
REMARK 465     THR B   828                                                      
REMARK 465     GLY B   829                                                      
REMARK 465     LYS B   830                                                      
REMARK 465     THR B   831                                                      
REMARK 465     SER B   832                                                      
REMARK 465     ARG B   833                                                      
REMARK 465     ARG B   834                                                      
REMARK 465     GLY B   835                                                      
REMARK 465     ARG B   836                                                      
REMARK 465     ALA B   837                                                      
REMARK 465     LEU B   838                                                      
REMARK 465     LEU B   839                                                      
REMARK 465     ALA B   840                                                      
REMARK 465     VAL B   841                                                      
REMARK 465     ALA B   842                                                      
REMARK 465     LEU B   843                                                      
REMARK 465     ASN B   844                                                      
REMARK 465     LEU B   845                                                      
REMARK 465     LEU B   846                                                      
REMARK 465     ALA B   847                                                      
REMARK 465     LEU B   848                                                      
REMARK 465     LEU B   849                                                      
REMARK 465     PHE B   850                                                      
REMARK 465     ALA B   851                                                      
REMARK 465     THR B   852                                                      
REMARK 465     THR B   853                                                      
REMARK 465     ALA B   854                                                      
REMARK 465     PHE B   855                                                      
REMARK 465     LEU B   856                                                      
REMARK 465     THR B   857                                                      
REMARK 465     THR B   858                                                      
REMARK 465     TYR B   859                                                      
REMARK 465     TRP B   860                                                      
REMARK 465     CYS B   861                                                      
REMARK 465     GLN B   862                                                      
REMARK 465     GLY B   863                                                      
REMARK 465     THR B   864                                                      
REMARK 465     GLN B   865                                                      
REMARK 465     ARG B   866                                                      
REMARK 465     VAL B   867                                                      
REMARK 465     PRO B   868                                                      
REMARK 465     LYS B   869                                                      
REMARK 465     PRO B   870                                                      
REMARK 465     GLY B   871                                                      
REMARK 465     CYS B   872                                                      
REMARK 465     GLY B   873                                                      
REMARK 465     GLN B   874                                                      
REMARK 465     GLY B   875                                                      
REMARK 465     GLY B   876                                                      
REMARK 465     GLY B   877                                                      
REMARK 465     ALA B   878                                                      
REMARK 465     ASN B   879                                                      
REMARK 465     CYS B   880                                                      
REMARK 465     PRO B   881                                                      
REMARK 465     ASN B   882                                                      
REMARK 465     SER B   883                                                      
REMARK 465     GLY B   884                                                      
REMARK 465     ALA B   885                                                      
REMARK 465     ASN B   886                                                      
REMARK 465     ALA B   887                                                      
REMARK 465     THR B   888                                                      
REMARK 465     ALA B   889                                                      
REMARK 465     ASN B   890                                                      
REMARK 465     SER B   891                                                      
REMARK 465     THR B   892                                                      
REMARK 465     ALA B   893                                                      
REMARK 465     ALA B   894                                                      
REMARK 465     PRO B   895                                                      
REMARK 465     VAL B   896                                                      
REMARK 465     ALA B   897                                                      
REMARK 465     ALA B   898                                                      
REMARK 465     SER B   899                                                      
REMARK 465     PRO B   900                                                      
REMARK 465     ALA B   901                                                      
REMARK 465     GLY B   902                                                      
REMARK 465     ALA B   903                                                      
REMARK 465     PRO B   904                                                      
REMARK 465     TYR B   905                                                      
REMARK 465     SER B   906                                                      
REMARK 465     TRP B   907                                                      
REMARK 465     GLU B   908                                                      
REMARK 465     ALA B   909                                                      
REMARK 465     GLY B   910                                                      
REMARK 465     ASP B   911                                                      
REMARK 465     GLU B   912                                                      
REMARK 465     ARG B   913                                                      
REMARK 465     PHE B   914                                                      
REMARK 465     GLN B   915                                                      
REMARK 465     LEU B   916                                                      
REMARK 465     ARG B   917                                                      
REMARK 465     ARG B   918                                                      
REMARK 465     PHE B   919                                                      
REMARK 465     HIS B   920                                                      
REMARK 465     THR B   921                                                      
REMARK 465     GLY B   922                                                      
REMARK 465     ILE B   923                                                      
REMARK 465     TRP B   924                                                      
REMARK 465     TYR B   925                                                      
REMARK 465     SER B   926                                                      
REMARK 465     CYS B   927                                                      
REMARK 465     GLU B   928                                                      
REMARK 465     GLU B   929                                                      
REMARK 465     GLU B   930                                                      
REMARK 465     LEU B   931                                                      
REMARK 465     GLY B   932                                                      
REMARK 465     GLY B   933                                                      
REMARK 465     PRO B   934                                                      
REMARK 465     GLY B   935                                                      
REMARK 465     GLU B   936                                                      
REMARK 465     LYS B   937                                                      
REMARK 465     CYS B   938                                                      
REMARK 465     ARG B   939                                                      
REMARK 465     SER B   940                                                      
REMARK 465     PHE B   941                                                      
REMARK 465     ILE B   942                                                      
REMARK 465     ASP B   943                                                      
REMARK 465     LEU B   944                                                      
REMARK 465     ALA B   945                                                      
REMARK 465     PRO B   946                                                      
REMARK 465     ALA B   947                                                      
REMARK 465     SER B   948                                                      
REMARK 465     GLU B   949                                                      
REMARK 465     LYS B   950                                                      
REMARK 465     GLY B   951                                                      
REMARK 465     VAL B   952                                                      
REMARK 465     LEU B   953                                                      
REMARK 465     TRP B   954                                                      
REMARK 465     LEU B   955                                                      
REMARK 465     SER B   956                                                      
REMARK 465     VAL B   957                                                      
REMARK 465     VAL B   958                                                      
REMARK 465     SER B   959                                                      
REMARK 465     GLU B   960                                                      
REMARK 465     VAL B   961                                                      
REMARK 465     LEU B   962                                                      
REMARK 465     TYR B   963                                                      
REMARK 465     ILE B   964                                                      
REMARK 465     LEU B   965                                                      
REMARK 465     LEU B   966                                                      
REMARK 465     LEU B   967                                                      
REMARK 465     VAL B   968                                                      
REMARK 465     VAL B   969                                                      
REMARK 465     GLY B   970                                                      
REMARK 465     PHE B   971                                                      
REMARK 465     SER B   972                                                      
REMARK 465     LEU B   973                                                      
REMARK 465     MET B   974                                                      
REMARK 465     CYS B   975                                                      
REMARK 465     LEU B   976                                                      
REMARK 465     GLU B   977                                                      
REMARK 465     LEU B   978                                                      
REMARK 465     LEU B   979                                                      
REMARK 465     HIS B   980                                                      
REMARK 465     SER B   981                                                      
REMARK 465     SER B   982                                                      
REMARK 465     SER B   983                                                      
REMARK 465     VAL B   984                                                      
REMARK 465     ILE B   985                                                      
REMARK 465     ASP B   986                                                      
REMARK 465     GLY B   987                                                      
REMARK 465     LEU B   988                                                      
REMARK 465     LYS B   989                                                      
REMARK 465     LEU B   990                                                      
REMARK 465     ASN B   991                                                      
REMARK 465     ALA B   992                                                      
REMARK 465     PHE B   993                                                      
REMARK 465     ALA B   994                                                      
REMARK 465     ALA B   995                                                      
REMARK 465     VAL B   996                                                      
REMARK 465     PHE B   997                                                      
REMARK 465     THR B   998                                                      
REMARK 465     VAL B   999                                                      
REMARK 465     LEU B  1000                                                      
REMARK 465     SER B  1001                                                      
REMARK 465     GLY B  1002                                                      
REMARK 465     LEU B  1003                                                      
REMARK 465     LEU B  1004                                                      
REMARK 465     GLY B  1005                                                      
REMARK 465     MET B  1006                                                      
REMARK 465     VAL B  1007                                                      
REMARK 465     ALA B  1008                                                      
REMARK 465     HIS B  1009                                                      
REMARK 465     MET B  1010                                                      
REMARK 465     MET B  1011                                                      
REMARK 465     TYR B  1012                                                      
REMARK 465     THR B  1013                                                      
REMARK 465     GLN B  1014                                                      
REMARK 465     VAL B  1015                                                      
REMARK 465     PHE B  1016                                                      
REMARK 465     GLN B  1017                                                      
REMARK 465     VAL B  1018                                                      
REMARK 465     THR B  1019                                                      
REMARK 465     VAL B  1020                                                      
REMARK 465     SER B  1021                                                      
REMARK 465     LEU B  1022                                                      
REMARK 465     GLY B  1023                                                      
REMARK 465     PRO B  1024                                                      
REMARK 465     GLU B  1025                                                      
REMARK 465     ASP B  1026                                                      
REMARK 465     TRP B  1027                                                      
REMARK 465     ARG B  1028                                                      
REMARK 465     PRO B  1029                                                      
REMARK 465     HIS B  1030                                                      
REMARK 465     SER B  1031                                                      
REMARK 465     TRP B  1032                                                      
REMARK 465     ASP B  1033                                                      
REMARK 465     TYR B  1034                                                      
REMARK 465     GLY B  1035                                                      
REMARK 465     TRP B  1036                                                      
REMARK 465     SER B  1037                                                      
REMARK 465     PHE B  1038                                                      
REMARK 465     CYS B  1039                                                      
REMARK 465     LEU B  1040                                                      
REMARK 465     ALA B  1041                                                      
REMARK 465     TRP B  1042                                                      
REMARK 465     GLY B  1043                                                      
REMARK 465     SER B  1044                                                      
REMARK 465     PHE B  1045                                                      
REMARK 465     THR B  1046                                                      
REMARK 465     CYS B  1047                                                      
REMARK 465     CYS B  1048                                                      
REMARK 465     MET B  1049                                                      
REMARK 465     ALA B  1050                                                      
REMARK 465     ALA B  1051                                                      
REMARK 465     SER B  1052                                                      
REMARK 465     VAL B  1053                                                      
REMARK 465     THR B  1054                                                      
REMARK 465     THR B  1055                                                      
REMARK 465     LEU B  1056                                                      
REMARK 465     ASN B  1057                                                      
REMARK 465     SER B  1058                                                      
REMARK 465     TYR B  1059                                                      
REMARK 465     THR B  1060                                                      
REMARK 465     LYS B  1061                                                      
REMARK 465     THR B  1062                                                      
REMARK 465     VAL B  1063                                                      
REMARK 465     ILE B  1064                                                      
REMARK 465     GLU B  1065                                                      
REMARK 465     PHE B  1066                                                      
REMARK 465     ARG C   545                                                      
REMARK 465     PHE C   546                                                      
REMARK 465     SER C   547                                                      
REMARK 465     PRO C   548                                                      
REMARK 465     TYR C   549                                                      
REMARK 465     GLU C   550                                                      
REMARK 465     TRP C   551                                                      
REMARK 465     HIS C   552                                                      
REMARK 465     THR C   553                                                      
REMARK 465     GLU C   554                                                      
REMARK 465     GLU C   555                                                      
REMARK 465     PHE C   556                                                      
REMARK 465     GLU C   557                                                      
REMARK 465     ASP C   558                                                      
REMARK 465     GLY C   559                                                      
REMARK 465     ARG C   560                                                      
REMARK 465     GLU C   561                                                      
REMARK 465     THR C   562                                                      
REMARK 465     GLN C   563                                                      
REMARK 465     SER C   564                                                      
REMARK 465     SER C   565                                                      
REMARK 465     GLU C   566                                                      
REMARK 465     SER C   567                                                      
REMARK 465     THR C   568                                                      
REMARK 465     ASN C   569                                                      
REMARK 465     GLU C   570                                                      
REMARK 465     PHE C   571                                                      
REMARK 465     GLY C   572                                                      
REMARK 465     GLU C   821                                                      
REMARK 465     ALA C   822                                                      
REMARK 465     LYS C   823                                                      
REMARK 465     ARG C   824                                                      
REMARK 465     MET C   825                                                      
REMARK 465     LYS C   826                                                      
REMARK 465     GLY C   827                                                      
REMARK 465     THR C   828                                                      
REMARK 465     GLY C   829                                                      
REMARK 465     LYS C   830                                                      
REMARK 465     THR C   831                                                      
REMARK 465     SER C   832                                                      
REMARK 465     ARG C   833                                                      
REMARK 465     ARG C   834                                                      
REMARK 465     GLY C   835                                                      
REMARK 465     ARG C   836                                                      
REMARK 465     ALA C   837                                                      
REMARK 465     LEU C   838                                                      
REMARK 465     LEU C   839                                                      
REMARK 465     ALA C   840                                                      
REMARK 465     VAL C   841                                                      
REMARK 465     ALA C   842                                                      
REMARK 465     LEU C   843                                                      
REMARK 465     ASN C   844                                                      
REMARK 465     LEU C   845                                                      
REMARK 465     LEU C   846                                                      
REMARK 465     ALA C   847                                                      
REMARK 465     LEU C   848                                                      
REMARK 465     LEU C   849                                                      
REMARK 465     PHE C   850                                                      
REMARK 465     ALA C   851                                                      
REMARK 465     THR C   852                                                      
REMARK 465     THR C   853                                                      
REMARK 465     ALA C   854                                                      
REMARK 465     PHE C   855                                                      
REMARK 465     LEU C   856                                                      
REMARK 465     THR C   857                                                      
REMARK 465     THR C   858                                                      
REMARK 465     TYR C   859                                                      
REMARK 465     TRP C   860                                                      
REMARK 465     CYS C   861                                                      
REMARK 465     GLN C   862                                                      
REMARK 465     GLY C   863                                                      
REMARK 465     THR C   864                                                      
REMARK 465     GLN C   865                                                      
REMARK 465     ARG C   866                                                      
REMARK 465     VAL C   867                                                      
REMARK 465     PRO C   868                                                      
REMARK 465     LYS C   869                                                      
REMARK 465     PRO C   870                                                      
REMARK 465     GLY C   871                                                      
REMARK 465     CYS C   872                                                      
REMARK 465     GLY C   873                                                      
REMARK 465     GLN C   874                                                      
REMARK 465     GLY C   875                                                      
REMARK 465     GLY C   876                                                      
REMARK 465     GLY C   877                                                      
REMARK 465     ALA C   878                                                      
REMARK 465     ASN C   879                                                      
REMARK 465     CYS C   880                                                      
REMARK 465     PRO C   881                                                      
REMARK 465     ASN C   882                                                      
REMARK 465     SER C   883                                                      
REMARK 465     GLY C   884                                                      
REMARK 465     ALA C   885                                                      
REMARK 465     ASN C   886                                                      
REMARK 465     ALA C   887                                                      
REMARK 465     THR C   888                                                      
REMARK 465     ALA C   889                                                      
REMARK 465     ASN C   890                                                      
REMARK 465     SER C   891                                                      
REMARK 465     THR C   892                                                      
REMARK 465     ALA C   893                                                      
REMARK 465     ALA C   894                                                      
REMARK 465     PRO C   895                                                      
REMARK 465     VAL C   896                                                      
REMARK 465     ALA C   897                                                      
REMARK 465     ALA C   898                                                      
REMARK 465     SER C   899                                                      
REMARK 465     PRO C   900                                                      
REMARK 465     ALA C   901                                                      
REMARK 465     GLY C   902                                                      
REMARK 465     ALA C   903                                                      
REMARK 465     PRO C   904                                                      
REMARK 465     TYR C   905                                                      
REMARK 465     SER C   906                                                      
REMARK 465     TRP C   907                                                      
REMARK 465     GLU C   908                                                      
REMARK 465     ALA C   909                                                      
REMARK 465     GLY C   910                                                      
REMARK 465     ASP C   911                                                      
REMARK 465     GLU C   912                                                      
REMARK 465     ARG C   913                                                      
REMARK 465     PHE C   914                                                      
REMARK 465     GLN C   915                                                      
REMARK 465     LEU C   916                                                      
REMARK 465     ARG C   917                                                      
REMARK 465     ARG C   918                                                      
REMARK 465     PHE C   919                                                      
REMARK 465     HIS C   920                                                      
REMARK 465     THR C   921                                                      
REMARK 465     GLY C   922                                                      
REMARK 465     ILE C   923                                                      
REMARK 465     TRP C   924                                                      
REMARK 465     TYR C   925                                                      
REMARK 465     SER C   926                                                      
REMARK 465     CYS C   927                                                      
REMARK 465     GLU C   928                                                      
REMARK 465     GLU C   929                                                      
REMARK 465     GLU C   930                                                      
REMARK 465     LEU C   931                                                      
REMARK 465     GLY C   932                                                      
REMARK 465     GLY C   933                                                      
REMARK 465     PRO C   934                                                      
REMARK 465     GLY C   935                                                      
REMARK 465     GLU C   936                                                      
REMARK 465     LYS C   937                                                      
REMARK 465     CYS C   938                                                      
REMARK 465     ARG C   939                                                      
REMARK 465     SER C   940                                                      
REMARK 465     PHE C   941                                                      
REMARK 465     ILE C   942                                                      
REMARK 465     ASP C   943                                                      
REMARK 465     LEU C   944                                                      
REMARK 465     ALA C   945                                                      
REMARK 465     PRO C   946                                                      
REMARK 465     ALA C   947                                                      
REMARK 465     SER C   948                                                      
REMARK 465     GLU C   949                                                      
REMARK 465     LYS C   950                                                      
REMARK 465     GLY C   951                                                      
REMARK 465     VAL C   952                                                      
REMARK 465     LEU C   953                                                      
REMARK 465     TRP C   954                                                      
REMARK 465     LEU C   955                                                      
REMARK 465     SER C   956                                                      
REMARK 465     VAL C   957                                                      
REMARK 465     VAL C   958                                                      
REMARK 465     SER C   959                                                      
REMARK 465     GLU C   960                                                      
REMARK 465     VAL C   961                                                      
REMARK 465     LEU C   962                                                      
REMARK 465     TYR C   963                                                      
REMARK 465     ILE C   964                                                      
REMARK 465     LEU C   965                                                      
REMARK 465     LEU C   966                                                      
REMARK 465     LEU C   967                                                      
REMARK 465     VAL C   968                                                      
REMARK 465     VAL C   969                                                      
REMARK 465     GLY C   970                                                      
REMARK 465     PHE C   971                                                      
REMARK 465     SER C   972                                                      
REMARK 465     LEU C   973                                                      
REMARK 465     MET C   974                                                      
REMARK 465     CYS C   975                                                      
REMARK 465     LEU C   976                                                      
REMARK 465     GLU C   977                                                      
REMARK 465     LEU C   978                                                      
REMARK 465     LEU C   979                                                      
REMARK 465     HIS C   980                                                      
REMARK 465     SER C   981                                                      
REMARK 465     SER C   982                                                      
REMARK 465     SER C   983                                                      
REMARK 465     VAL C   984                                                      
REMARK 465     ILE C   985                                                      
REMARK 465     ASP C   986                                                      
REMARK 465     GLY C   987                                                      
REMARK 465     LEU C   988                                                      
REMARK 465     LYS C   989                                                      
REMARK 465     LEU C   990                                                      
REMARK 465     ASN C   991                                                      
REMARK 465     ALA C   992                                                      
REMARK 465     PHE C   993                                                      
REMARK 465     ALA C   994                                                      
REMARK 465     ALA C   995                                                      
REMARK 465     VAL C   996                                                      
REMARK 465     PHE C   997                                                      
REMARK 465     THR C   998                                                      
REMARK 465     VAL C   999                                                      
REMARK 465     LEU C  1000                                                      
REMARK 465     SER C  1001                                                      
REMARK 465     GLY C  1002                                                      
REMARK 465     LEU C  1003                                                      
REMARK 465     LEU C  1004                                                      
REMARK 465     GLY C  1005                                                      
REMARK 465     MET C  1006                                                      
REMARK 465     VAL C  1007                                                      
REMARK 465     ALA C  1008                                                      
REMARK 465     HIS C  1009                                                      
REMARK 465     MET C  1010                                                      
REMARK 465     MET C  1011                                                      
REMARK 465     TYR C  1012                                                      
REMARK 465     THR C  1013                                                      
REMARK 465     GLN C  1014                                                      
REMARK 465     VAL C  1015                                                      
REMARK 465     PHE C  1016                                                      
REMARK 465     GLN C  1017                                                      
REMARK 465     VAL C  1018                                                      
REMARK 465     THR C  1019                                                      
REMARK 465     VAL C  1020                                                      
REMARK 465     SER C  1021                                                      
REMARK 465     LEU C  1022                                                      
REMARK 465     GLY C  1023                                                      
REMARK 465     PRO C  1024                                                      
REMARK 465     GLU C  1025                                                      
REMARK 465     ASP C  1026                                                      
REMARK 465     TRP C  1027                                                      
REMARK 465     ARG C  1028                                                      
REMARK 465     PRO C  1029                                                      
REMARK 465     HIS C  1030                                                      
REMARK 465     SER C  1031                                                      
REMARK 465     TRP C  1032                                                      
REMARK 465     ASP C  1033                                                      
REMARK 465     TYR C  1034                                                      
REMARK 465     GLY C  1035                                                      
REMARK 465     TRP C  1036                                                      
REMARK 465     SER C  1037                                                      
REMARK 465     PHE C  1038                                                      
REMARK 465     CYS C  1039                                                      
REMARK 465     LEU C  1040                                                      
REMARK 465     ALA C  1041                                                      
REMARK 465     TRP C  1042                                                      
REMARK 465     GLY C  1043                                                      
REMARK 465     SER C  1044                                                      
REMARK 465     PHE C  1045                                                      
REMARK 465     THR C  1046                                                      
REMARK 465     CYS C  1047                                                      
REMARK 465     CYS C  1048                                                      
REMARK 465     MET C  1049                                                      
REMARK 465     ALA C  1050                                                      
REMARK 465     ALA C  1051                                                      
REMARK 465     SER C  1052                                                      
REMARK 465     VAL C  1053                                                      
REMARK 465     THR C  1054                                                      
REMARK 465     THR C  1055                                                      
REMARK 465     LEU C  1056                                                      
REMARK 465     ASN C  1057                                                      
REMARK 465     SER C  1058                                                      
REMARK 465     TYR C  1059                                                      
REMARK 465     THR C  1060                                                      
REMARK 465     LYS C  1061                                                      
REMARK 465     THR C  1062                                                      
REMARK 465     VAL C  1063                                                      
REMARK 465     ILE C  1064                                                      
REMARK 465     GLU C  1065                                                      
REMARK 465     PHE C  1066                                                      
REMARK 465     ARG D   545                                                      
REMARK 465     PHE D   546                                                      
REMARK 465     SER D   547                                                      
REMARK 465     PRO D   548                                                      
REMARK 465     TYR D   549                                                      
REMARK 465     GLU D   550                                                      
REMARK 465     TRP D   551                                                      
REMARK 465     HIS D   552                                                      
REMARK 465     THR D   553                                                      
REMARK 465     GLU D   554                                                      
REMARK 465     GLU D   555                                                      
REMARK 465     PHE D   556                                                      
REMARK 465     GLU D   557                                                      
REMARK 465     ASP D   558                                                      
REMARK 465     GLY D   559                                                      
REMARK 465     ARG D   560                                                      
REMARK 465     GLU D   561                                                      
REMARK 465     THR D   562                                                      
REMARK 465     GLN D   563                                                      
REMARK 465     SER D   564                                                      
REMARK 465     SER D   565                                                      
REMARK 465     GLU D   566                                                      
REMARK 465     SER D   567                                                      
REMARK 465     THR D   568                                                      
REMARK 465     ASN D   569                                                      
REMARK 465     GLU D   570                                                      
REMARK 465     PHE D   571                                                      
REMARK 465     GLY D   572                                                      
REMARK 465     SER D   818                                                      
REMARK 465     ARG D   819                                                      
REMARK 465     ALA D   820                                                      
REMARK 465     GLU D   821                                                      
REMARK 465     ALA D   822                                                      
REMARK 465     LYS D   823                                                      
REMARK 465     ARG D   824                                                      
REMARK 465     MET D   825                                                      
REMARK 465     LYS D   826                                                      
REMARK 465     GLY D   827                                                      
REMARK 465     THR D   828                                                      
REMARK 465     GLY D   829                                                      
REMARK 465     LYS D   830                                                      
REMARK 465     THR D   831                                                      
REMARK 465     SER D   832                                                      
REMARK 465     ARG D   833                                                      
REMARK 465     ARG D   834                                                      
REMARK 465     GLY D   835                                                      
REMARK 465     ARG D   836                                                      
REMARK 465     ALA D   837                                                      
REMARK 465     LEU D   838                                                      
REMARK 465     LEU D   839                                                      
REMARK 465     ALA D   840                                                      
REMARK 465     VAL D   841                                                      
REMARK 465     ALA D   842                                                      
REMARK 465     LEU D   843                                                      
REMARK 465     ASN D   844                                                      
REMARK 465     LEU D   845                                                      
REMARK 465     LEU D   846                                                      
REMARK 465     ALA D   847                                                      
REMARK 465     LEU D   848                                                      
REMARK 465     LEU D   849                                                      
REMARK 465     PHE D   850                                                      
REMARK 465     ALA D   851                                                      
REMARK 465     THR D   852                                                      
REMARK 465     THR D   853                                                      
REMARK 465     ALA D   854                                                      
REMARK 465     PHE D   855                                                      
REMARK 465     LEU D   856                                                      
REMARK 465     THR D   857                                                      
REMARK 465     THR D   858                                                      
REMARK 465     TYR D   859                                                      
REMARK 465     TRP D   860                                                      
REMARK 465     CYS D   861                                                      
REMARK 465     GLN D   862                                                      
REMARK 465     GLY D   863                                                      
REMARK 465     THR D   864                                                      
REMARK 465     GLN D   865                                                      
REMARK 465     ARG D   866                                                      
REMARK 465     VAL D   867                                                      
REMARK 465     PRO D   868                                                      
REMARK 465     LYS D   869                                                      
REMARK 465     PRO D   870                                                      
REMARK 465     GLY D   871                                                      
REMARK 465     CYS D   872                                                      
REMARK 465     GLY D   873                                                      
REMARK 465     GLN D   874                                                      
REMARK 465     GLY D   875                                                      
REMARK 465     GLY D   876                                                      
REMARK 465     GLY D   877                                                      
REMARK 465     ALA D   878                                                      
REMARK 465     ASN D   879                                                      
REMARK 465     CYS D   880                                                      
REMARK 465     PRO D   881                                                      
REMARK 465     ASN D   882                                                      
REMARK 465     SER D   883                                                      
REMARK 465     GLY D   884                                                      
REMARK 465     ALA D   885                                                      
REMARK 465     ASN D   886                                                      
REMARK 465     ALA D   887                                                      
REMARK 465     THR D   888                                                      
REMARK 465     ALA D   889                                                      
REMARK 465     ASN D   890                                                      
REMARK 465     SER D   891                                                      
REMARK 465     THR D   892                                                      
REMARK 465     ALA D   893                                                      
REMARK 465     ALA D   894                                                      
REMARK 465     PRO D   895                                                      
REMARK 465     VAL D   896                                                      
REMARK 465     ALA D   897                                                      
REMARK 465     ALA D   898                                                      
REMARK 465     SER D   899                                                      
REMARK 465     PRO D   900                                                      
REMARK 465     ALA D   901                                                      
REMARK 465     GLY D   902                                                      
REMARK 465     ALA D   903                                                      
REMARK 465     PRO D   904                                                      
REMARK 465     TYR D   905                                                      
REMARK 465     SER D   906                                                      
REMARK 465     TRP D   907                                                      
REMARK 465     GLU D   908                                                      
REMARK 465     ALA D   909                                                      
REMARK 465     GLY D   910                                                      
REMARK 465     ASP D   911                                                      
REMARK 465     GLU D   912                                                      
REMARK 465     ARG D   913                                                      
REMARK 465     PHE D   914                                                      
REMARK 465     GLN D   915                                                      
REMARK 465     LEU D   916                                                      
REMARK 465     ARG D   917                                                      
REMARK 465     ARG D   918                                                      
REMARK 465     PHE D   919                                                      
REMARK 465     HIS D   920                                                      
REMARK 465     THR D   921                                                      
REMARK 465     GLY D   922                                                      
REMARK 465     ILE D   923                                                      
REMARK 465     TRP D   924                                                      
REMARK 465     TYR D   925                                                      
REMARK 465     SER D   926                                                      
REMARK 465     CYS D   927                                                      
REMARK 465     GLU D   928                                                      
REMARK 465     GLU D   929                                                      
REMARK 465     GLU D   930                                                      
REMARK 465     LEU D   931                                                      
REMARK 465     GLY D   932                                                      
REMARK 465     GLY D   933                                                      
REMARK 465     PRO D   934                                                      
REMARK 465     GLY D   935                                                      
REMARK 465     GLU D   936                                                      
REMARK 465     LYS D   937                                                      
REMARK 465     CYS D   938                                                      
REMARK 465     ARG D   939                                                      
REMARK 465     SER D   940                                                      
REMARK 465     PHE D   941                                                      
REMARK 465     ILE D   942                                                      
REMARK 465     ASP D   943                                                      
REMARK 465     LEU D   944                                                      
REMARK 465     ALA D   945                                                      
REMARK 465     PRO D   946                                                      
REMARK 465     ALA D   947                                                      
REMARK 465     SER D   948                                                      
REMARK 465     GLU D   949                                                      
REMARK 465     LYS D   950                                                      
REMARK 465     GLY D   951                                                      
REMARK 465     VAL D   952                                                      
REMARK 465     LEU D   953                                                      
REMARK 465     TRP D   954                                                      
REMARK 465     LEU D   955                                                      
REMARK 465     SER D   956                                                      
REMARK 465     VAL D   957                                                      
REMARK 465     VAL D   958                                                      
REMARK 465     SER D   959                                                      
REMARK 465     GLU D   960                                                      
REMARK 465     VAL D   961                                                      
REMARK 465     LEU D   962                                                      
REMARK 465     TYR D   963                                                      
REMARK 465     ILE D   964                                                      
REMARK 465     LEU D   965                                                      
REMARK 465     LEU D   966                                                      
REMARK 465     LEU D   967                                                      
REMARK 465     VAL D   968                                                      
REMARK 465     VAL D   969                                                      
REMARK 465     GLY D   970                                                      
REMARK 465     PHE D   971                                                      
REMARK 465     SER D   972                                                      
REMARK 465     LEU D   973                                                      
REMARK 465     MET D   974                                                      
REMARK 465     CYS D   975                                                      
REMARK 465     LEU D   976                                                      
REMARK 465     GLU D   977                                                      
REMARK 465     LEU D   978                                                      
REMARK 465     LEU D   979                                                      
REMARK 465     HIS D   980                                                      
REMARK 465     SER D   981                                                      
REMARK 465     SER D   982                                                      
REMARK 465     SER D   983                                                      
REMARK 465     VAL D   984                                                      
REMARK 465     ILE D   985                                                      
REMARK 465     ASP D   986                                                      
REMARK 465     GLY D   987                                                      
REMARK 465     LEU D   988                                                      
REMARK 465     LYS D   989                                                      
REMARK 465     LEU D   990                                                      
REMARK 465     ASN D   991                                                      
REMARK 465     ALA D   992                                                      
REMARK 465     PHE D   993                                                      
REMARK 465     ALA D   994                                                      
REMARK 465     ALA D   995                                                      
REMARK 465     VAL D   996                                                      
REMARK 465     PHE D   997                                                      
REMARK 465     THR D   998                                                      
REMARK 465     VAL D   999                                                      
REMARK 465     LEU D  1000                                                      
REMARK 465     SER D  1001                                                      
REMARK 465     GLY D  1002                                                      
REMARK 465     LEU D  1003                                                      
REMARK 465     LEU D  1004                                                      
REMARK 465     GLY D  1005                                                      
REMARK 465     MET D  1006                                                      
REMARK 465     VAL D  1007                                                      
REMARK 465     ALA D  1008                                                      
REMARK 465     HIS D  1009                                                      
REMARK 465     MET D  1010                                                      
REMARK 465     MET D  1011                                                      
REMARK 465     TYR D  1012                                                      
REMARK 465     THR D  1013                                                      
REMARK 465     GLN D  1014                                                      
REMARK 465     VAL D  1015                                                      
REMARK 465     PHE D  1016                                                      
REMARK 465     GLN D  1017                                                      
REMARK 465     VAL D  1018                                                      
REMARK 465     THR D  1019                                                      
REMARK 465     VAL D  1020                                                      
REMARK 465     SER D  1021                                                      
REMARK 465     LEU D  1022                                                      
REMARK 465     GLY D  1023                                                      
REMARK 465     PRO D  1024                                                      
REMARK 465     GLU D  1025                                                      
REMARK 465     ASP D  1026                                                      
REMARK 465     TRP D  1027                                                      
REMARK 465     ARG D  1028                                                      
REMARK 465     PRO D  1029                                                      
REMARK 465     HIS D  1030                                                      
REMARK 465     SER D  1031                                                      
REMARK 465     TRP D  1032                                                      
REMARK 465     ASP D  1033                                                      
REMARK 465     TYR D  1034                                                      
REMARK 465     GLY D  1035                                                      
REMARK 465     TRP D  1036                                                      
REMARK 465     SER D  1037                                                      
REMARK 465     PHE D  1038                                                      
REMARK 465     CYS D  1039                                                      
REMARK 465     LEU D  1040                                                      
REMARK 465     ALA D  1041                                                      
REMARK 465     TRP D  1042                                                      
REMARK 465     GLY D  1043                                                      
REMARK 465     SER D  1044                                                      
REMARK 465     PHE D  1045                                                      
REMARK 465     THR D  1046                                                      
REMARK 465     CYS D  1047                                                      
REMARK 465     CYS D  1048                                                      
REMARK 465     MET D  1049                                                      
REMARK 465     ALA D  1050                                                      
REMARK 465     ALA D  1051                                                      
REMARK 465     SER D  1052                                                      
REMARK 465     VAL D  1053                                                      
REMARK 465     THR D  1054                                                      
REMARK 465     THR D  1055                                                      
REMARK 465     LEU D  1056                                                      
REMARK 465     ASN D  1057                                                      
REMARK 465     SER D  1058                                                      
REMARK 465     TYR D  1059                                                      
REMARK 465     THR D  1060                                                      
REMARK 465     LYS D  1061                                                      
REMARK 465     THR D  1062                                                      
REMARK 465     VAL D  1063                                                      
REMARK 465     ILE D  1064                                                      
REMARK 465     GLU D  1065                                                      
REMARK 465     PHE D  1066                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ILE A 573    CG1  CG2  CD1                                       
REMARK 470     ILE B 573    CG1  CG2  CD1                                       
REMARK 470     ILE C 573    CG1  CG2  CD1                                       
REMARK 470     ILE D 573    CG1  CG2  CD1                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   SG   CYS D   718     CB   CYS D   773              1.52            
REMARK 500   OH   TYR B    77     O    PHE B   101              2.06            
REMARK 500   OH   TYR D    77     O    PHE D   101              2.09            
REMARK 500   OE1  GLU B   705     FAF  ZK1 B  1101              2.09            
REMARK 500   OE1  GLU D   705     FAF  ZK1 D  1101              2.11            
REMARK 500   O    ARG D   692     OG   SER D   696              2.11            
REMARK 500   O    ARG B   692     OG   SER B   696              2.12            
REMARK 500   O    SER B   537     OG   SER B   576              2.12            
REMARK 500   OG   SER A    11     OG1  THR A    44              2.12            
REMARK 500   O    SER D   537     OG   SER D   576              2.12            
REMARK 500   OH   TYR C    77     O    PHE C   101              2.13            
REMARK 500   OG1  THR B   228     OE1  GLN B   246              2.15            
REMARK 500   O    GLY C   513     OG   SER C   516              2.16            
REMARK 500   OH   TYR A    77     O    PHE A   101              2.16            
REMARK 500   OG   SER C    11     OG1  THR C    44              2.17            
REMARK 500   O    ARG D   261     OG1  THR D   264              2.17            
REMARK 500   O    ARG B   261     OG1  THR B   264              2.18            
REMARK 500   NH2  ARG D   308     OE1  GLN D   325              2.19            
REMARK 500   N    ASN D   355     OE2  GLU D   376              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO B  99   C   -  N   -  CA  ANGL. DEV. =   9.2 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU A  17       75.46   -118.28                                   
REMARK 500    ALA A  22       55.38    -99.11                                   
REMARK 500    HIS A  46       63.49   -115.04                                   
REMARK 500    LYS A 173       68.27    -65.14                                   
REMARK 500    ASP A 174      -47.56   -167.75                                   
REMARK 500    TRP A 262      -70.71    -78.50                                   
REMARK 500    LYS A 379     -146.33     55.08                                   
REMARK 500    ASP A 385       88.96    -47.46                                   
REMARK 500    LEU A 390      -77.64    -74.07                                   
REMARK 500    THR A 394       93.29     54.63                                   
REMARK 500    ASP A 456      -79.59    -76.86                                   
REMARK 500    PRO A 478       73.12    -60.47                                   
REMARK 500    MET A 496       92.84   -163.96                                   
REMARK 500    VAL A 514      -48.79     63.57                                   
REMARK 500    PHE A 574      -29.76   -160.09                                   
REMARK 500    ASN A 575      -76.75    -52.45                                   
REMARK 500    GLN A 587      -77.33     56.68                                   
REMARK 500    CYS A 589      169.30     60.95                                   
REMARK 500    ILE A 591       -5.93     60.98                                   
REMARK 500    ARG A 594      108.50     59.64                                   
REMARK 500    SER A 595      -71.40     57.97                                   
REMARK 500    LEU A 596      -91.85     52.33                                   
REMARK 500    SER A 597      -69.99   -152.16                                   
REMARK 500    THR A 643      -16.41   -153.36                                   
REMARK 500    LYS A 765      -80.81    -66.89                                   
REMARK 500    TYR A 768      -49.03   -142.73                                   
REMARK 500    GLU A 782     -163.81     58.25                                   
REMARK 500    LYS A 783      -95.24   -131.37                                   
REMARK 500    THR A 784      -89.45   -123.00                                   
REMARK 500    SER A 785     -155.21     57.06                                   
REMARK 500    LEU A 787      179.40     57.24                                   
REMARK 500    ALA B  22       41.80   -102.14                                   
REMARK 500    ASN B  49       49.84   -108.87                                   
REMARK 500    SER B 100     -179.40    -63.49                                   
REMARK 500    GLN B 159       54.07   -115.27                                   
REMARK 500    LYS B 173       81.42    -62.94                                   
REMARK 500    ASP B 174      -85.74   -166.24                                   
REMARK 500    THR B 277     -161.84   -126.71                                   
REMARK 500    LYS B 379     -145.11     55.15                                   
REMARK 500    THR B 387     -115.05    -94.32                                   
REMARK 500    THR B 394       50.41     34.58                                   
REMARK 500    VAL B 395       92.03      1.33                                   
REMARK 500    ASN B 461     -162.26   -106.69                                   
REMARK 500    PRO B 478       85.08    -58.18                                   
REMARK 500    GLN B 508       70.55   -154.85                                   
REMARK 500    SER B 510       29.40   -149.61                                   
REMARK 500    PRO B 512     -117.25    -97.01                                   
REMARK 500    VAL B 514      -44.67     67.83                                   
REMARK 500    GLN B 587      -78.69     55.72                                   
REMARK 500    CYS B 589      162.21     63.21                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     132 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 610                                                                      
REMARK 610 MISSING HETEROATOM                                                   
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 610 I=INSERTION CODE):                                                   
REMARK 610   M RES C SSEQI                                                      
REMARK 610     NAG A 1102                                                       
REMARK 610     NAG B 1102                                                       
REMARK 610     NAG C 1102                                                       
REMARK 610     NAG D 1102                                                       
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZK1 A 1101                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NAG A 1102                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZK1 B 1101                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NAG B 1102                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZK1 C 1101                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NAG C 1102                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZK1 D 1101                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NAG D 1102                
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8685   RELATED DB: EMDB                              
REMARK 900 GLUA2-0XGSG1L BOUND TO ZK                                            
REMARK 900 RELATED ID: 5VHX   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHY   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 5VHZ   RELATED DB: PDB                                   
DBREF  5VHW A   10   826  UNP    P19491   GRIA2_RAT       25    847             
DBREF  5VHW A  830  1066  UNP    D3ZK93   GSG1L_RAT        2    238             
DBREF  5VHW B   10   826  UNP    P19491   GRIA2_RAT       25    847             
DBREF  5VHW B  830  1066  UNP    D3ZK93   GSG1L_RAT        2    238             
DBREF  5VHW C   10   826  UNP    P19491   GRIA2_RAT       25    847             
DBREF  5VHW C  830  1066  UNP    D3ZK93   GSG1L_RAT        2    238             
DBREF  5VHW D   10   826  UNP    P19491   GRIA2_RAT       25    847             
DBREF  5VHW D  830  1066  UNP    D3ZK93   GSG1L_RAT        2    238             
SEQADV 5VHW GLU A  241  UNP  P19491    ASN   256 CONFLICT                       
SEQADV 5VHW LEU A  382  UNP  P19491    VAL   397 CONFLICT                       
SEQADV 5VHW     A       UNP  P19491    LEU   399 DELETION                       
SEQADV 5VHW     A       UNP  P19491    THR   400 DELETION                       
SEQADV 5VHW     A       UNP  P19491    GLU   401 DELETION                       
SEQADV 5VHW     A       UNP  P19491    LEU   402 DELETION                       
SEQADV 5VHW     A       UNP  P19491    PRO   403 DELETION                       
SEQADV 5VHW     A       UNP  P19491    SER   404 DELETION                       
SEQADV 5VHW GLU A  384  UNP  P19491    GLY   405 CONFLICT                       
SEQADV 5VHW ASP A  385  UNP  P19491    ASN   406 CONFLICT                       
SEQADV 5VHW GLN A  392  UNP  P19491    ASN   413 CONFLICT                       
SEQADV 5VHW GLY A  827  UNP  P19491              LINKER                         
SEQADV 5VHW THR A  828  UNP  P19491              LINKER                         
SEQADV 5VHW GLY A  829  UNP  P19491              LINKER                         
SEQADV 5VHW GLU B  241  UNP  P19491    ASN   256 CONFLICT                       
SEQADV 5VHW LEU B  382  UNP  P19491    VAL   397 CONFLICT                       
SEQADV 5VHW     B       UNP  P19491    LEU   399 DELETION                       
SEQADV 5VHW     B       UNP  P19491    THR   400 DELETION                       
SEQADV 5VHW     B       UNP  P19491    GLU   401 DELETION                       
SEQADV 5VHW     B       UNP  P19491    LEU   402 DELETION                       
SEQADV 5VHW     B       UNP  P19491    PRO   403 DELETION                       
SEQADV 5VHW     B       UNP  P19491    SER   404 DELETION                       
SEQADV 5VHW GLU B  384  UNP  P19491    GLY   405 CONFLICT                       
SEQADV 5VHW ASP B  385  UNP  P19491    ASN   406 CONFLICT                       
SEQADV 5VHW GLN B  392  UNP  P19491    ASN   413 CONFLICT                       
SEQADV 5VHW GLY B  827  UNP  P19491              LINKER                         
SEQADV 5VHW THR B  828  UNP  P19491              LINKER                         
SEQADV 5VHW GLY B  829  UNP  P19491              LINKER                         
SEQADV 5VHW GLU C  241  UNP  P19491    ASN   256 CONFLICT                       
SEQADV 5VHW LEU C  382  UNP  P19491    VAL   397 CONFLICT                       
SEQADV 5VHW     C       UNP  P19491    LEU   399 DELETION                       
SEQADV 5VHW     C       UNP  P19491    THR   400 DELETION                       
SEQADV 5VHW     C       UNP  P19491    GLU   401 DELETION                       
SEQADV 5VHW     C       UNP  P19491    LEU   402 DELETION                       
SEQADV 5VHW     C       UNP  P19491    PRO   403 DELETION                       
SEQADV 5VHW     C       UNP  P19491    SER   404 DELETION                       
SEQADV 5VHW GLU C  384  UNP  P19491    GLY   405 CONFLICT                       
SEQADV 5VHW ASP C  385  UNP  P19491    ASN   406 CONFLICT                       
SEQADV 5VHW GLN C  392  UNP  P19491    ASN   413 CONFLICT                       
SEQADV 5VHW GLY C  827  UNP  P19491              LINKER                         
SEQADV 5VHW THR C  828  UNP  P19491              LINKER                         
SEQADV 5VHW GLY C  829  UNP  P19491              LINKER                         
SEQADV 5VHW GLU D  241  UNP  P19491    ASN   256 CONFLICT                       
SEQADV 5VHW LEU D  382  UNP  P19491    VAL   397 CONFLICT                       
SEQADV 5VHW     D       UNP  P19491    LEU   399 DELETION                       
SEQADV 5VHW     D       UNP  P19491    THR   400 DELETION                       
SEQADV 5VHW     D       UNP  P19491    GLU   401 DELETION                       
SEQADV 5VHW     D       UNP  P19491    LEU   402 DELETION                       
SEQADV 5VHW     D       UNP  P19491    PRO   403 DELETION                       
SEQADV 5VHW     D       UNP  P19491    SER   404 DELETION                       
SEQADV 5VHW GLU D  384  UNP  P19491    GLY   405 CONFLICT                       
SEQADV 5VHW ASP D  385  UNP  P19491    ASN   406 CONFLICT                       
SEQADV 5VHW GLN D  392  UNP  P19491    ASN   413 CONFLICT                       
SEQADV 5VHW GLY D  827  UNP  P19491              LINKER                         
SEQADV 5VHW THR D  828  UNP  P19491              LINKER                         
SEQADV 5VHW GLY D  829  UNP  P19491              LINKER                         
SEQRES   1 A 1057  ASN SER ILE GLN ILE GLY GLY LEU PHE PRO ARG GLY ALA          
SEQRES   2 A 1057  ASP GLN GLU TYR SER ALA PHE ARG VAL GLY MET VAL GLN          
SEQRES   3 A 1057  PHE SER THR SER GLU PHE ARG LEU THR PRO HIS ILE ASP          
SEQRES   4 A 1057  ASN LEU GLU VAL ALA ASN SER PHE ALA VAL THR ASN ALA          
SEQRES   5 A 1057  PHE CYS SER GLN PHE SER ARG GLY VAL TYR ALA ILE PHE          
SEQRES   6 A 1057  GLY PHE TYR ASP LYS LYS SER VAL ASN THR ILE THR SER          
SEQRES   7 A 1057  PHE CYS GLY THR LEU HIS VAL SER PHE ILE THR PRO SER          
SEQRES   8 A 1057  PHE PRO THR ASP GLY THR HIS PRO PHE VAL ILE GLN MET          
SEQRES   9 A 1057  ARG PRO ASP LEU LYS GLY ALA LEU LEU SER LEU ILE GLU          
SEQRES  10 A 1057  TYR TYR GLN TRP ASP LYS PHE ALA TYR LEU TYR ASP SER          
SEQRES  11 A 1057  ASP ARG GLY LEU SER THR LEU GLN ALA VAL LEU ASP SER          
SEQRES  12 A 1057  ALA ALA GLU LYS LYS TRP GLN VAL THR ALA ILE ASN VAL          
SEQRES  13 A 1057  GLY ASN ILE ASN ASN ASP LYS LYS ASP GLU THR TYR ARG          
SEQRES  14 A 1057  SER LEU PHE GLN ASP LEU GLU LEU LYS LYS GLU ARG ARG          
SEQRES  15 A 1057  VAL ILE LEU ASP CYS GLU ARG ASP LYS VAL ASN ASP ILE          
SEQRES  16 A 1057  VAL ASP GLN VAL ILE THR ILE GLY LYS HIS VAL LYS GLY          
SEQRES  17 A 1057  TYR HIS TYR ILE ILE ALA ASN LEU GLY PHE THR ASP GLY          
SEQRES  18 A 1057  ASP LEU LEU LYS ILE GLN PHE GLY GLY ALA GLU VAL SER          
SEQRES  19 A 1057  GLY PHE GLN ILE VAL ASP TYR ASP ASP SER LEU VAL SER          
SEQRES  20 A 1057  LYS PHE ILE GLU ARG TRP SER THR LEU GLU GLU LYS GLU          
SEQRES  21 A 1057  TYR PRO GLY ALA HIS THR ALA THR ILE LYS TYR THR SER          
SEQRES  22 A 1057  ALA LEU THR TYR ASP ALA VAL GLN VAL MET THR GLU ALA          
SEQRES  23 A 1057  PHE ARG ASN LEU ARG LYS GLN ARG ILE GLU ILE SER ARG          
SEQRES  24 A 1057  ARG GLY ASN ALA GLY ASP CYS LEU ALA ASN PRO ALA VAL          
SEQRES  25 A 1057  PRO TRP GLY GLN GLY VAL GLU ILE GLU ARG ALA LEU LYS          
SEQRES  26 A 1057  GLN VAL GLN VAL GLU GLY LEU SER GLY ASN ILE LYS PHE          
SEQRES  27 A 1057  ASP GLN ASN GLY LYS ARG ILE ASN TYR THR ILE ASN ILE          
SEQRES  28 A 1057  MET GLU LEU LYS THR ASN GLY PRO ARG LYS ILE GLY TYR          
SEQRES  29 A 1057  TRP SER GLU VAL ASP LYS MET VAL LEU THR GLU ASP ASP          
SEQRES  30 A 1057  THR SER GLY LEU GLU GLN LYS THR VAL VAL VAL THR THR          
SEQRES  31 A 1057  ILE LEU GLU SER PRO TYR VAL MET MET LYS LYS ASN HIS          
SEQRES  32 A 1057  GLU MET LEU GLU GLY ASN GLU ARG TYR GLU GLY TYR CYS          
SEQRES  33 A 1057  VAL ASP LEU ALA ALA GLU ILE ALA LYS HIS CYS GLY PHE          
SEQRES  34 A 1057  LYS TYR LYS LEU THR ILE VAL GLY ASP GLY LYS TYR GLY          
SEQRES  35 A 1057  ALA ARG ASP ALA ASP THR LYS ILE TRP ASN GLY MET VAL          
SEQRES  36 A 1057  GLY GLU LEU VAL TYR GLY LYS ALA ASP ILE ALA ILE ALA          
SEQRES  37 A 1057  PRO LEU THR ILE THR LEU VAL ARG GLU GLU VAL ILE ASP          
SEQRES  38 A 1057  PHE SER LYS PRO PHE MET SER LEU GLY ILE SER ILE MET          
SEQRES  39 A 1057  ILE LYS LYS PRO GLN LYS SER LYS PRO GLY VAL PHE SER          
SEQRES  40 A 1057  PHE LEU ASP PRO LEU ALA TYR GLU ILE TRP MET CYS ILE          
SEQRES  41 A 1057  VAL PHE ALA TYR ILE GLY VAL SER VAL VAL LEU PHE LEU          
SEQRES  42 A 1057  VAL SER ARG PHE SER PRO TYR GLU TRP HIS THR GLU GLU          
SEQRES  43 A 1057  PHE GLU ASP GLY ARG GLU THR GLN SER SER GLU SER THR          
SEQRES  44 A 1057  ASN GLU PHE GLY ILE PHE ASN SER LEU TRP PHE SER LEU          
SEQRES  45 A 1057  GLY ALA PHE MET GLN GLN GLY CYS ASP ILE SER PRO ARG          
SEQRES  46 A 1057  SER LEU SER GLY ARG ILE VAL GLY GLY VAL TRP TRP PHE          
SEQRES  47 A 1057  PHE THR LEU ILE ILE ILE SER SER TYR THR ALA ASN LEU          
SEQRES  48 A 1057  ALA ALA PHE LEU THR VAL GLU ARG MET VAL SER PRO ILE          
SEQRES  49 A 1057  GLU SER ALA GLU ASP LEU SER LYS GLN THR GLU ILE ALA          
SEQRES  50 A 1057  TYR GLY THR LEU ASP SER GLY SER THR LYS GLU PHE PHE          
SEQRES  51 A 1057  ARG ARG SER LYS ILE ALA VAL PHE ASP LYS MET TRP THR          
SEQRES  52 A 1057  TYR MET ARG SER ALA GLU PRO SER VAL PHE VAL ARG THR          
SEQRES  53 A 1057  THR ALA GLU GLY VAL ALA ARG VAL ARG LYS SER LYS GLY          
SEQRES  54 A 1057  LYS TYR ALA TYR LEU LEU GLU SER THR MET ASN GLU TYR          
SEQRES  55 A 1057  ILE GLU GLN ARG LYS PRO CYS ASP THR MET LYS VAL GLY          
SEQRES  56 A 1057  GLY ASN LEU ASP SER LYS GLY TYR GLY ILE ALA THR PRO          
SEQRES  57 A 1057  LYS GLY SER SER LEU GLY THR PRO VAL ASN LEU ALA VAL          
SEQRES  58 A 1057  LEU LYS LEU SER GLU GLN GLY VAL LEU ASP LYS LEU LYS          
SEQRES  59 A 1057  ASN LYS TRP TRP TYR ASP LYS GLY GLU CYS GLY ALA LYS          
SEQRES  60 A 1057  ASP SER GLY SER LYS GLU LYS THR SER ALA LEU SER LEU          
SEQRES  61 A 1057  SER ASN VAL ALA GLY VAL PHE TYR ILE LEU VAL GLY GLY          
SEQRES  62 A 1057  LEU GLY LEU ALA MET LEU VAL ALA LEU ILE GLU PHE CYS          
SEQRES  63 A 1057  TYR LYS SER ARG ALA GLU ALA LYS ARG MET LYS GLY THR          
SEQRES  64 A 1057  GLY LYS THR SER ARG ARG GLY ARG ALA LEU LEU ALA VAL          
SEQRES  65 A 1057  ALA LEU ASN LEU LEU ALA LEU LEU PHE ALA THR THR ALA          
SEQRES  66 A 1057  PHE LEU THR THR TYR TRP CYS GLN GLY THR GLN ARG VAL          
SEQRES  67 A 1057  PRO LYS PRO GLY CYS GLY GLN GLY GLY GLY ALA ASN CYS          
SEQRES  68 A 1057  PRO ASN SER GLY ALA ASN ALA THR ALA ASN SER THR ALA          
SEQRES  69 A 1057  ALA PRO VAL ALA ALA SER PRO ALA GLY ALA PRO TYR SER          
SEQRES  70 A 1057  TRP GLU ALA GLY ASP GLU ARG PHE GLN LEU ARG ARG PHE          
SEQRES  71 A 1057  HIS THR GLY ILE TRP TYR SER CYS GLU GLU GLU LEU GLY          
SEQRES  72 A 1057  GLY PRO GLY GLU LYS CYS ARG SER PHE ILE ASP LEU ALA          
SEQRES  73 A 1057  PRO ALA SER GLU LYS GLY VAL LEU TRP LEU SER VAL VAL          
SEQRES  74 A 1057  SER GLU VAL LEU TYR ILE LEU LEU LEU VAL VAL GLY PHE          
SEQRES  75 A 1057  SER LEU MET CYS LEU GLU LEU LEU HIS SER SER SER VAL          
SEQRES  76 A 1057  ILE ASP GLY LEU LYS LEU ASN ALA PHE ALA ALA VAL PHE          
SEQRES  77 A 1057  THR VAL LEU SER GLY LEU LEU GLY MET VAL ALA HIS MET          
SEQRES  78 A 1057  MET TYR THR GLN VAL PHE GLN VAL THR VAL SER LEU GLY          
SEQRES  79 A 1057  PRO GLU ASP TRP ARG PRO HIS SER TRP ASP TYR GLY TRP          
SEQRES  80 A 1057  SER PHE CYS LEU ALA TRP GLY SER PHE THR CYS CYS MET          
SEQRES  81 A 1057  ALA ALA SER VAL THR THR LEU ASN SER TYR THR LYS THR          
SEQRES  82 A 1057  VAL ILE GLU PHE                                              
SEQRES   1 B 1057  ASN SER ILE GLN ILE GLY GLY LEU PHE PRO ARG GLY ALA          
SEQRES   2 B 1057  ASP GLN GLU TYR SER ALA PHE ARG VAL GLY MET VAL GLN          
SEQRES   3 B 1057  PHE SER THR SER GLU PHE ARG LEU THR PRO HIS ILE ASP          
SEQRES   4 B 1057  ASN LEU GLU VAL ALA ASN SER PHE ALA VAL THR ASN ALA          
SEQRES   5 B 1057  PHE CYS SER GLN PHE SER ARG GLY VAL TYR ALA ILE PHE          
SEQRES   6 B 1057  GLY PHE TYR ASP LYS LYS SER VAL ASN THR ILE THR SER          
SEQRES   7 B 1057  PHE CYS GLY THR LEU HIS VAL SER PHE ILE THR PRO SER          
SEQRES   8 B 1057  PHE PRO THR ASP GLY THR HIS PRO PHE VAL ILE GLN MET          
SEQRES   9 B 1057  ARG PRO ASP LEU LYS GLY ALA LEU LEU SER LEU ILE GLU          
SEQRES  10 B 1057  TYR TYR GLN TRP ASP LYS PHE ALA TYR LEU TYR ASP SER          
SEQRES  11 B 1057  ASP ARG GLY LEU SER THR LEU GLN ALA VAL LEU ASP SER          
SEQRES  12 B 1057  ALA ALA GLU LYS LYS TRP GLN VAL THR ALA ILE ASN VAL          
SEQRES  13 B 1057  GLY ASN ILE ASN ASN ASP LYS LYS ASP GLU THR TYR ARG          
SEQRES  14 B 1057  SER LEU PHE GLN ASP LEU GLU LEU LYS LYS GLU ARG ARG          
SEQRES  15 B 1057  VAL ILE LEU ASP CYS GLU ARG ASP LYS VAL ASN ASP ILE          
SEQRES  16 B 1057  VAL ASP GLN VAL ILE THR ILE GLY LYS HIS VAL LYS GLY          
SEQRES  17 B 1057  TYR HIS TYR ILE ILE ALA ASN LEU GLY PHE THR ASP GLY          
SEQRES  18 B 1057  ASP LEU LEU LYS ILE GLN PHE GLY GLY ALA GLU VAL SER          
SEQRES  19 B 1057  GLY PHE GLN ILE VAL ASP TYR ASP ASP SER LEU VAL SER          
SEQRES  20 B 1057  LYS PHE ILE GLU ARG TRP SER THR LEU GLU GLU LYS GLU          
SEQRES  21 B 1057  TYR PRO GLY ALA HIS THR ALA THR ILE LYS TYR THR SER          
SEQRES  22 B 1057  ALA LEU THR TYR ASP ALA VAL GLN VAL MET THR GLU ALA          
SEQRES  23 B 1057  PHE ARG ASN LEU ARG LYS GLN ARG ILE GLU ILE SER ARG          
SEQRES  24 B 1057  ARG GLY ASN ALA GLY ASP CYS LEU ALA ASN PRO ALA VAL          
SEQRES  25 B 1057  PRO TRP GLY GLN GLY VAL GLU ILE GLU ARG ALA LEU LYS          
SEQRES  26 B 1057  GLN VAL GLN VAL GLU GLY LEU SER GLY ASN ILE LYS PHE          
SEQRES  27 B 1057  ASP GLN ASN GLY LYS ARG ILE ASN TYR THR ILE ASN ILE          
SEQRES  28 B 1057  MET GLU LEU LYS THR ASN GLY PRO ARG LYS ILE GLY TYR          
SEQRES  29 B 1057  TRP SER GLU VAL ASP LYS MET VAL LEU THR GLU ASP ASP          
SEQRES  30 B 1057  THR SER GLY LEU GLU GLN LYS THR VAL VAL VAL THR THR          
SEQRES  31 B 1057  ILE LEU GLU SER PRO TYR VAL MET MET LYS LYS ASN HIS          
SEQRES  32 B 1057  GLU MET LEU GLU GLY ASN GLU ARG TYR GLU GLY TYR CYS          
SEQRES  33 B 1057  VAL ASP LEU ALA ALA GLU ILE ALA LYS HIS CYS GLY PHE          
SEQRES  34 B 1057  LYS TYR LYS LEU THR ILE VAL GLY ASP GLY LYS TYR GLY          
SEQRES  35 B 1057  ALA ARG ASP ALA ASP THR LYS ILE TRP ASN GLY MET VAL          
SEQRES  36 B 1057  GLY GLU LEU VAL TYR GLY LYS ALA ASP ILE ALA ILE ALA          
SEQRES  37 B 1057  PRO LEU THR ILE THR LEU VAL ARG GLU GLU VAL ILE ASP          
SEQRES  38 B 1057  PHE SER LYS PRO PHE MET SER LEU GLY ILE SER ILE MET          
SEQRES  39 B 1057  ILE LYS LYS PRO GLN LYS SER LYS PRO GLY VAL PHE SER          
SEQRES  40 B 1057  PHE LEU ASP PRO LEU ALA TYR GLU ILE TRP MET CYS ILE          
SEQRES  41 B 1057  VAL PHE ALA TYR ILE GLY VAL SER VAL VAL LEU PHE LEU          
SEQRES  42 B 1057  VAL SER ARG PHE SER PRO TYR GLU TRP HIS THR GLU GLU          
SEQRES  43 B 1057  PHE GLU ASP GLY ARG GLU THR GLN SER SER GLU SER THR          
SEQRES  44 B 1057  ASN GLU PHE GLY ILE PHE ASN SER LEU TRP PHE SER LEU          
SEQRES  45 B 1057  GLY ALA PHE MET GLN GLN GLY CYS ASP ILE SER PRO ARG          
SEQRES  46 B 1057  SER LEU SER GLY ARG ILE VAL GLY GLY VAL TRP TRP PHE          
SEQRES  47 B 1057  PHE THR LEU ILE ILE ILE SER SER TYR THR ALA ASN LEU          
SEQRES  48 B 1057  ALA ALA PHE LEU THR VAL GLU ARG MET VAL SER PRO ILE          
SEQRES  49 B 1057  GLU SER ALA GLU ASP LEU SER LYS GLN THR GLU ILE ALA          
SEQRES  50 B 1057  TYR GLY THR LEU ASP SER GLY SER THR LYS GLU PHE PHE          
SEQRES  51 B 1057  ARG ARG SER LYS ILE ALA VAL PHE ASP LYS MET TRP THR          
SEQRES  52 B 1057  TYR MET ARG SER ALA GLU PRO SER VAL PHE VAL ARG THR          
SEQRES  53 B 1057  THR ALA GLU GLY VAL ALA ARG VAL ARG LYS SER LYS GLY          
SEQRES  54 B 1057  LYS TYR ALA TYR LEU LEU GLU SER THR MET ASN GLU TYR          
SEQRES  55 B 1057  ILE GLU GLN ARG LYS PRO CYS ASP THR MET LYS VAL GLY          
SEQRES  56 B 1057  GLY ASN LEU ASP SER LYS GLY TYR GLY ILE ALA THR PRO          
SEQRES  57 B 1057  LYS GLY SER SER LEU GLY THR PRO VAL ASN LEU ALA VAL          
SEQRES  58 B 1057  LEU LYS LEU SER GLU GLN GLY VAL LEU ASP LYS LEU LYS          
SEQRES  59 B 1057  ASN LYS TRP TRP TYR ASP LYS GLY GLU CYS GLY ALA LYS          
SEQRES  60 B 1057  ASP SER GLY SER LYS GLU LYS THR SER ALA LEU SER LEU          
SEQRES  61 B 1057  SER ASN VAL ALA GLY VAL PHE TYR ILE LEU VAL GLY GLY          
SEQRES  62 B 1057  LEU GLY LEU ALA MET LEU VAL ALA LEU ILE GLU PHE CYS          
SEQRES  63 B 1057  TYR LYS SER ARG ALA GLU ALA LYS ARG MET LYS GLY THR          
SEQRES  64 B 1057  GLY LYS THR SER ARG ARG GLY ARG ALA LEU LEU ALA VAL          
SEQRES  65 B 1057  ALA LEU ASN LEU LEU ALA LEU LEU PHE ALA THR THR ALA          
SEQRES  66 B 1057  PHE LEU THR THR TYR TRP CYS GLN GLY THR GLN ARG VAL          
SEQRES  67 B 1057  PRO LYS PRO GLY CYS GLY GLN GLY GLY GLY ALA ASN CYS          
SEQRES  68 B 1057  PRO ASN SER GLY ALA ASN ALA THR ALA ASN SER THR ALA          
SEQRES  69 B 1057  ALA PRO VAL ALA ALA SER PRO ALA GLY ALA PRO TYR SER          
SEQRES  70 B 1057  TRP GLU ALA GLY ASP GLU ARG PHE GLN LEU ARG ARG PHE          
SEQRES  71 B 1057  HIS THR GLY ILE TRP TYR SER CYS GLU GLU GLU LEU GLY          
SEQRES  72 B 1057  GLY PRO GLY GLU LYS CYS ARG SER PHE ILE ASP LEU ALA          
SEQRES  73 B 1057  PRO ALA SER GLU LYS GLY VAL LEU TRP LEU SER VAL VAL          
SEQRES  74 B 1057  SER GLU VAL LEU TYR ILE LEU LEU LEU VAL VAL GLY PHE          
SEQRES  75 B 1057  SER LEU MET CYS LEU GLU LEU LEU HIS SER SER SER VAL          
SEQRES  76 B 1057  ILE ASP GLY LEU LYS LEU ASN ALA PHE ALA ALA VAL PHE          
SEQRES  77 B 1057  THR VAL LEU SER GLY LEU LEU GLY MET VAL ALA HIS MET          
SEQRES  78 B 1057  MET TYR THR GLN VAL PHE GLN VAL THR VAL SER LEU GLY          
SEQRES  79 B 1057  PRO GLU ASP TRP ARG PRO HIS SER TRP ASP TYR GLY TRP          
SEQRES  80 B 1057  SER PHE CYS LEU ALA TRP GLY SER PHE THR CYS CYS MET          
SEQRES  81 B 1057  ALA ALA SER VAL THR THR LEU ASN SER TYR THR LYS THR          
SEQRES  82 B 1057  VAL ILE GLU PHE                                              
SEQRES   1 C 1057  ASN SER ILE GLN ILE GLY GLY LEU PHE PRO ARG GLY ALA          
SEQRES   2 C 1057  ASP GLN GLU TYR SER ALA PHE ARG VAL GLY MET VAL GLN          
SEQRES   3 C 1057  PHE SER THR SER GLU PHE ARG LEU THR PRO HIS ILE ASP          
SEQRES   4 C 1057  ASN LEU GLU VAL ALA ASN SER PHE ALA VAL THR ASN ALA          
SEQRES   5 C 1057  PHE CYS SER GLN PHE SER ARG GLY VAL TYR ALA ILE PHE          
SEQRES   6 C 1057  GLY PHE TYR ASP LYS LYS SER VAL ASN THR ILE THR SER          
SEQRES   7 C 1057  PHE CYS GLY THR LEU HIS VAL SER PHE ILE THR PRO SER          
SEQRES   8 C 1057  PHE PRO THR ASP GLY THR HIS PRO PHE VAL ILE GLN MET          
SEQRES   9 C 1057  ARG PRO ASP LEU LYS GLY ALA LEU LEU SER LEU ILE GLU          
SEQRES  10 C 1057  TYR TYR GLN TRP ASP LYS PHE ALA TYR LEU TYR ASP SER          
SEQRES  11 C 1057  ASP ARG GLY LEU SER THR LEU GLN ALA VAL LEU ASP SER          
SEQRES  12 C 1057  ALA ALA GLU LYS LYS TRP GLN VAL THR ALA ILE ASN VAL          
SEQRES  13 C 1057  GLY ASN ILE ASN ASN ASP LYS LYS ASP GLU THR TYR ARG          
SEQRES  14 C 1057  SER LEU PHE GLN ASP LEU GLU LEU LYS LYS GLU ARG ARG          
SEQRES  15 C 1057  VAL ILE LEU ASP CYS GLU ARG ASP LYS VAL ASN ASP ILE          
SEQRES  16 C 1057  VAL ASP GLN VAL ILE THR ILE GLY LYS HIS VAL LYS GLY          
SEQRES  17 C 1057  TYR HIS TYR ILE ILE ALA ASN LEU GLY PHE THR ASP GLY          
SEQRES  18 C 1057  ASP LEU LEU LYS ILE GLN PHE GLY GLY ALA GLU VAL SER          
SEQRES  19 C 1057  GLY PHE GLN ILE VAL ASP TYR ASP ASP SER LEU VAL SER          
SEQRES  20 C 1057  LYS PHE ILE GLU ARG TRP SER THR LEU GLU GLU LYS GLU          
SEQRES  21 C 1057  TYR PRO GLY ALA HIS THR ALA THR ILE LYS TYR THR SER          
SEQRES  22 C 1057  ALA LEU THR TYR ASP ALA VAL GLN VAL MET THR GLU ALA          
SEQRES  23 C 1057  PHE ARG ASN LEU ARG LYS GLN ARG ILE GLU ILE SER ARG          
SEQRES  24 C 1057  ARG GLY ASN ALA GLY ASP CYS LEU ALA ASN PRO ALA VAL          
SEQRES  25 C 1057  PRO TRP GLY GLN GLY VAL GLU ILE GLU ARG ALA LEU LYS          
SEQRES  26 C 1057  GLN VAL GLN VAL GLU GLY LEU SER GLY ASN ILE LYS PHE          
SEQRES  27 C 1057  ASP GLN ASN GLY LYS ARG ILE ASN TYR THR ILE ASN ILE          
SEQRES  28 C 1057  MET GLU LEU LYS THR ASN GLY PRO ARG LYS ILE GLY TYR          
SEQRES  29 C 1057  TRP SER GLU VAL ASP LYS MET VAL LEU THR GLU ASP ASP          
SEQRES  30 C 1057  THR SER GLY LEU GLU GLN LYS THR VAL VAL VAL THR THR          
SEQRES  31 C 1057  ILE LEU GLU SER PRO TYR VAL MET MET LYS LYS ASN HIS          
SEQRES  32 C 1057  GLU MET LEU GLU GLY ASN GLU ARG TYR GLU GLY TYR CYS          
SEQRES  33 C 1057  VAL ASP LEU ALA ALA GLU ILE ALA LYS HIS CYS GLY PHE          
SEQRES  34 C 1057  LYS TYR LYS LEU THR ILE VAL GLY ASP GLY LYS TYR GLY          
SEQRES  35 C 1057  ALA ARG ASP ALA ASP THR LYS ILE TRP ASN GLY MET VAL          
SEQRES  36 C 1057  GLY GLU LEU VAL TYR GLY LYS ALA ASP ILE ALA ILE ALA          
SEQRES  37 C 1057  PRO LEU THR ILE THR LEU VAL ARG GLU GLU VAL ILE ASP          
SEQRES  38 C 1057  PHE SER LYS PRO PHE MET SER LEU GLY ILE SER ILE MET          
SEQRES  39 C 1057  ILE LYS LYS PRO GLN LYS SER LYS PRO GLY VAL PHE SER          
SEQRES  40 C 1057  PHE LEU ASP PRO LEU ALA TYR GLU ILE TRP MET CYS ILE          
SEQRES  41 C 1057  VAL PHE ALA TYR ILE GLY VAL SER VAL VAL LEU PHE LEU          
SEQRES  42 C 1057  VAL SER ARG PHE SER PRO TYR GLU TRP HIS THR GLU GLU          
SEQRES  43 C 1057  PHE GLU ASP GLY ARG GLU THR GLN SER SER GLU SER THR          
SEQRES  44 C 1057  ASN GLU PHE GLY ILE PHE ASN SER LEU TRP PHE SER LEU          
SEQRES  45 C 1057  GLY ALA PHE MET GLN GLN GLY CYS ASP ILE SER PRO ARG          
SEQRES  46 C 1057  SER LEU SER GLY ARG ILE VAL GLY GLY VAL TRP TRP PHE          
SEQRES  47 C 1057  PHE THR LEU ILE ILE ILE SER SER TYR THR ALA ASN LEU          
SEQRES  48 C 1057  ALA ALA PHE LEU THR VAL GLU ARG MET VAL SER PRO ILE          
SEQRES  49 C 1057  GLU SER ALA GLU ASP LEU SER LYS GLN THR GLU ILE ALA          
SEQRES  50 C 1057  TYR GLY THR LEU ASP SER GLY SER THR LYS GLU PHE PHE          
SEQRES  51 C 1057  ARG ARG SER LYS ILE ALA VAL PHE ASP LYS MET TRP THR          
SEQRES  52 C 1057  TYR MET ARG SER ALA GLU PRO SER VAL PHE VAL ARG THR          
SEQRES  53 C 1057  THR ALA GLU GLY VAL ALA ARG VAL ARG LYS SER LYS GLY          
SEQRES  54 C 1057  LYS TYR ALA TYR LEU LEU GLU SER THR MET ASN GLU TYR          
SEQRES  55 C 1057  ILE GLU GLN ARG LYS PRO CYS ASP THR MET LYS VAL GLY          
SEQRES  56 C 1057  GLY ASN LEU ASP SER LYS GLY TYR GLY ILE ALA THR PRO          
SEQRES  57 C 1057  LYS GLY SER SER LEU GLY THR PRO VAL ASN LEU ALA VAL          
SEQRES  58 C 1057  LEU LYS LEU SER GLU GLN GLY VAL LEU ASP LYS LEU LYS          
SEQRES  59 C 1057  ASN LYS TRP TRP TYR ASP LYS GLY GLU CYS GLY ALA LYS          
SEQRES  60 C 1057  ASP SER GLY SER LYS GLU LYS THR SER ALA LEU SER LEU          
SEQRES  61 C 1057  SER ASN VAL ALA GLY VAL PHE TYR ILE LEU VAL GLY GLY          
SEQRES  62 C 1057  LEU GLY LEU ALA MET LEU VAL ALA LEU ILE GLU PHE CYS          
SEQRES  63 C 1057  TYR LYS SER ARG ALA GLU ALA LYS ARG MET LYS GLY THR          
SEQRES  64 C 1057  GLY LYS THR SER ARG ARG GLY ARG ALA LEU LEU ALA VAL          
SEQRES  65 C 1057  ALA LEU ASN LEU LEU ALA LEU LEU PHE ALA THR THR ALA          
SEQRES  66 C 1057  PHE LEU THR THR TYR TRP CYS GLN GLY THR GLN ARG VAL          
SEQRES  67 C 1057  PRO LYS PRO GLY CYS GLY GLN GLY GLY GLY ALA ASN CYS          
SEQRES  68 C 1057  PRO ASN SER GLY ALA ASN ALA THR ALA ASN SER THR ALA          
SEQRES  69 C 1057  ALA PRO VAL ALA ALA SER PRO ALA GLY ALA PRO TYR SER          
SEQRES  70 C 1057  TRP GLU ALA GLY ASP GLU ARG PHE GLN LEU ARG ARG PHE          
SEQRES  71 C 1057  HIS THR GLY ILE TRP TYR SER CYS GLU GLU GLU LEU GLY          
SEQRES  72 C 1057  GLY PRO GLY GLU LYS CYS ARG SER PHE ILE ASP LEU ALA          
SEQRES  73 C 1057  PRO ALA SER GLU LYS GLY VAL LEU TRP LEU SER VAL VAL          
SEQRES  74 C 1057  SER GLU VAL LEU TYR ILE LEU LEU LEU VAL VAL GLY PHE          
SEQRES  75 C 1057  SER LEU MET CYS LEU GLU LEU LEU HIS SER SER SER VAL          
SEQRES  76 C 1057  ILE ASP GLY LEU LYS LEU ASN ALA PHE ALA ALA VAL PHE          
SEQRES  77 C 1057  THR VAL LEU SER GLY LEU LEU GLY MET VAL ALA HIS MET          
SEQRES  78 C 1057  MET TYR THR GLN VAL PHE GLN VAL THR VAL SER LEU GLY          
SEQRES  79 C 1057  PRO GLU ASP TRP ARG PRO HIS SER TRP ASP TYR GLY TRP          
SEQRES  80 C 1057  SER PHE CYS LEU ALA TRP GLY SER PHE THR CYS CYS MET          
SEQRES  81 C 1057  ALA ALA SER VAL THR THR LEU ASN SER TYR THR LYS THR          
SEQRES  82 C 1057  VAL ILE GLU PHE                                              
SEQRES   1 D 1057  ASN SER ILE GLN ILE GLY GLY LEU PHE PRO ARG GLY ALA          
SEQRES   2 D 1057  ASP GLN GLU TYR SER ALA PHE ARG VAL GLY MET VAL GLN          
SEQRES   3 D 1057  PHE SER THR SER GLU PHE ARG LEU THR PRO HIS ILE ASP          
SEQRES   4 D 1057  ASN LEU GLU VAL ALA ASN SER PHE ALA VAL THR ASN ALA          
SEQRES   5 D 1057  PHE CYS SER GLN PHE SER ARG GLY VAL TYR ALA ILE PHE          
SEQRES   6 D 1057  GLY PHE TYR ASP LYS LYS SER VAL ASN THR ILE THR SER          
SEQRES   7 D 1057  PHE CYS GLY THR LEU HIS VAL SER PHE ILE THR PRO SER          
SEQRES   8 D 1057  PHE PRO THR ASP GLY THR HIS PRO PHE VAL ILE GLN MET          
SEQRES   9 D 1057  ARG PRO ASP LEU LYS GLY ALA LEU LEU SER LEU ILE GLU          
SEQRES  10 D 1057  TYR TYR GLN TRP ASP LYS PHE ALA TYR LEU TYR ASP SER          
SEQRES  11 D 1057  ASP ARG GLY LEU SER THR LEU GLN ALA VAL LEU ASP SER          
SEQRES  12 D 1057  ALA ALA GLU LYS LYS TRP GLN VAL THR ALA ILE ASN VAL          
SEQRES  13 D 1057  GLY ASN ILE ASN ASN ASP LYS LYS ASP GLU THR TYR ARG          
SEQRES  14 D 1057  SER LEU PHE GLN ASP LEU GLU LEU LYS LYS GLU ARG ARG          
SEQRES  15 D 1057  VAL ILE LEU ASP CYS GLU ARG ASP LYS VAL ASN ASP ILE          
SEQRES  16 D 1057  VAL ASP GLN VAL ILE THR ILE GLY LYS HIS VAL LYS GLY          
SEQRES  17 D 1057  TYR HIS TYR ILE ILE ALA ASN LEU GLY PHE THR ASP GLY          
SEQRES  18 D 1057  ASP LEU LEU LYS ILE GLN PHE GLY GLY ALA GLU VAL SER          
SEQRES  19 D 1057  GLY PHE GLN ILE VAL ASP TYR ASP ASP SER LEU VAL SER          
SEQRES  20 D 1057  LYS PHE ILE GLU ARG TRP SER THR LEU GLU GLU LYS GLU          
SEQRES  21 D 1057  TYR PRO GLY ALA HIS THR ALA THR ILE LYS TYR THR SER          
SEQRES  22 D 1057  ALA LEU THR TYR ASP ALA VAL GLN VAL MET THR GLU ALA          
SEQRES  23 D 1057  PHE ARG ASN LEU ARG LYS GLN ARG ILE GLU ILE SER ARG          
SEQRES  24 D 1057  ARG GLY ASN ALA GLY ASP CYS LEU ALA ASN PRO ALA VAL          
SEQRES  25 D 1057  PRO TRP GLY GLN GLY VAL GLU ILE GLU ARG ALA LEU LYS          
SEQRES  26 D 1057  GLN VAL GLN VAL GLU GLY LEU SER GLY ASN ILE LYS PHE          
SEQRES  27 D 1057  ASP GLN ASN GLY LYS ARG ILE ASN TYR THR ILE ASN ILE          
SEQRES  28 D 1057  MET GLU LEU LYS THR ASN GLY PRO ARG LYS ILE GLY TYR          
SEQRES  29 D 1057  TRP SER GLU VAL ASP LYS MET VAL LEU THR GLU ASP ASP          
SEQRES  30 D 1057  THR SER GLY LEU GLU GLN LYS THR VAL VAL VAL THR THR          
SEQRES  31 D 1057  ILE LEU GLU SER PRO TYR VAL MET MET LYS LYS ASN HIS          
SEQRES  32 D 1057  GLU MET LEU GLU GLY ASN GLU ARG TYR GLU GLY TYR CYS          
SEQRES  33 D 1057  VAL ASP LEU ALA ALA GLU ILE ALA LYS HIS CYS GLY PHE          
SEQRES  34 D 1057  LYS TYR LYS LEU THR ILE VAL GLY ASP GLY LYS TYR GLY          
SEQRES  35 D 1057  ALA ARG ASP ALA ASP THR LYS ILE TRP ASN GLY MET VAL          
SEQRES  36 D 1057  GLY GLU LEU VAL TYR GLY LYS ALA ASP ILE ALA ILE ALA          
SEQRES  37 D 1057  PRO LEU THR ILE THR LEU VAL ARG GLU GLU VAL ILE ASP          
SEQRES  38 D 1057  PHE SER LYS PRO PHE MET SER LEU GLY ILE SER ILE MET          
SEQRES  39 D 1057  ILE LYS LYS PRO GLN LYS SER LYS PRO GLY VAL PHE SER          
SEQRES  40 D 1057  PHE LEU ASP PRO LEU ALA TYR GLU ILE TRP MET CYS ILE          
SEQRES  41 D 1057  VAL PHE ALA TYR ILE GLY VAL SER VAL VAL LEU PHE LEU          
SEQRES  42 D 1057  VAL SER ARG PHE SER PRO TYR GLU TRP HIS THR GLU GLU          
SEQRES  43 D 1057  PHE GLU ASP GLY ARG GLU THR GLN SER SER GLU SER THR          
SEQRES  44 D 1057  ASN GLU PHE GLY ILE PHE ASN SER LEU TRP PHE SER LEU          
SEQRES  45 D 1057  GLY ALA PHE MET GLN GLN GLY CYS ASP ILE SER PRO ARG          
SEQRES  46 D 1057  SER LEU SER GLY ARG ILE VAL GLY GLY VAL TRP TRP PHE          
SEQRES  47 D 1057  PHE THR LEU ILE ILE ILE SER SER TYR THR ALA ASN LEU          
SEQRES  48 D 1057  ALA ALA PHE LEU THR VAL GLU ARG MET VAL SER PRO ILE          
SEQRES  49 D 1057  GLU SER ALA GLU ASP LEU SER LYS GLN THR GLU ILE ALA          
SEQRES  50 D 1057  TYR GLY THR LEU ASP SER GLY SER THR LYS GLU PHE PHE          
SEQRES  51 D 1057  ARG ARG SER LYS ILE ALA VAL PHE ASP LYS MET TRP THR          
SEQRES  52 D 1057  TYR MET ARG SER ALA GLU PRO SER VAL PHE VAL ARG THR          
SEQRES  53 D 1057  THR ALA GLU GLY VAL ALA ARG VAL ARG LYS SER LYS GLY          
SEQRES  54 D 1057  LYS TYR ALA TYR LEU LEU GLU SER THR MET ASN GLU TYR          
SEQRES  55 D 1057  ILE GLU GLN ARG LYS PRO CYS ASP THR MET LYS VAL GLY          
SEQRES  56 D 1057  GLY ASN LEU ASP SER LYS GLY TYR GLY ILE ALA THR PRO          
SEQRES  57 D 1057  LYS GLY SER SER LEU GLY THR PRO VAL ASN LEU ALA VAL          
SEQRES  58 D 1057  LEU LYS LEU SER GLU GLN GLY VAL LEU ASP LYS LEU LYS          
SEQRES  59 D 1057  ASN LYS TRP TRP TYR ASP LYS GLY GLU CYS GLY ALA LYS          
SEQRES  60 D 1057  ASP SER GLY SER LYS GLU LYS THR SER ALA LEU SER LEU          
SEQRES  61 D 1057  SER ASN VAL ALA GLY VAL PHE TYR ILE LEU VAL GLY GLY          
SEQRES  62 D 1057  LEU GLY LEU ALA MET LEU VAL ALA LEU ILE GLU PHE CYS          
SEQRES  63 D 1057  TYR LYS SER ARG ALA GLU ALA LYS ARG MET LYS GLY THR          
SEQRES  64 D 1057  GLY LYS THR SER ARG ARG GLY ARG ALA LEU LEU ALA VAL          
SEQRES  65 D 1057  ALA LEU ASN LEU LEU ALA LEU LEU PHE ALA THR THR ALA          
SEQRES  66 D 1057  PHE LEU THR THR TYR TRP CYS GLN GLY THR GLN ARG VAL          
SEQRES  67 D 1057  PRO LYS PRO GLY CYS GLY GLN GLY GLY GLY ALA ASN CYS          
SEQRES  68 D 1057  PRO ASN SER GLY ALA ASN ALA THR ALA ASN SER THR ALA          
SEQRES  69 D 1057  ALA PRO VAL ALA ALA SER PRO ALA GLY ALA PRO TYR SER          
SEQRES  70 D 1057  TRP GLU ALA GLY ASP GLU ARG PHE GLN LEU ARG ARG PHE          
SEQRES  71 D 1057  HIS THR GLY ILE TRP TYR SER CYS GLU GLU GLU LEU GLY          
SEQRES  72 D 1057  GLY PRO GLY GLU LYS CYS ARG SER PHE ILE ASP LEU ALA          
SEQRES  73 D 1057  PRO ALA SER GLU LYS GLY VAL LEU TRP LEU SER VAL VAL          
SEQRES  74 D 1057  SER GLU VAL LEU TYR ILE LEU LEU LEU VAL VAL GLY PHE          
SEQRES  75 D 1057  SER LEU MET CYS LEU GLU LEU LEU HIS SER SER SER VAL          
SEQRES  76 D 1057  ILE ASP GLY LEU LYS LEU ASN ALA PHE ALA ALA VAL PHE          
SEQRES  77 D 1057  THR VAL LEU SER GLY LEU LEU GLY MET VAL ALA HIS MET          
SEQRES  78 D 1057  MET TYR THR GLN VAL PHE GLN VAL THR VAL SER LEU GLY          
SEQRES  79 D 1057  PRO GLU ASP TRP ARG PRO HIS SER TRP ASP TYR GLY TRP          
SEQRES  80 D 1057  SER PHE CYS LEU ALA TRP GLY SER PHE THR CYS CYS MET          
SEQRES  81 D 1057  ALA ALA SER VAL THR THR LEU ASN SER TYR THR LYS THR          
SEQRES  82 D 1057  VAL ILE GLU PHE                                              
HET    ZK1  A1101      27                                                       
HET    NAG  A1102      14                                                       
HET    ZK1  B1101      27                                                       
HET    NAG  B1102      14                                                       
HET    ZK1  C1101      27                                                       
HET    NAG  C1102      14                                                       
HET    ZK1  D1101      27                                                       
HET    NAG  D1102      14                                                       
HETNAM     ZK1 {[7-MORPHOLIN-4-YL-2,3-DIOXO-6-(TRIFLUOROMETHYL)-3,4-            
HETNAM   2 ZK1  DIHYDROQUINOXALIN-1(2H)-YL]METHYL}PHOSPHONIC ACID               
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE                                           
HETSYN     ZK1 [[3,4-DIHYDRO-7-(4-MORPHOLINYL)-2,3-DIOXO-6-(TRIFLUOROM          
HETSYN   2 ZK1  ETHYL)-1(2H)-QUINOXALINYL]METHYL]PHOSPHONIC ACID                
FORMUL   5  ZK1    4(C14 H15 F3 N3 O6 P)                                        
FORMUL   6  NAG    4(C8 H15 N O6)                                               
HELIX    1 AA1 ALA A   22  PHE A   36  1                                  15    
HELIX    2 AA2 ASN A   54  GLY A   69  1                                  16    
HELIX    3 AA3 ASP A   78  HIS A   93  1                                  16    
HELIX    4 AA4 LEU A  117  GLN A  129  1                                  13    
HELIX    5 AA5 LEU A  143  LYS A  157  1                                  15    
HELIX    6 AA6 GLY A  166  ILE A  168  5                                   3    
HELIX    7 AA7 ASN A  169  LYS A  173  5                                   5    
HELIX    8 AA8 ASP A  174  LEU A  186  1                                  13    
HELIX    9 AA9 GLU A  197  ILE A  211  1                                  15    
HELIX   10 AB1 GLY A  226  GLY A  230  5                                   5    
HELIX   11 AB2 ASP A  231  GLN A  236  5                                   6    
HELIX   12 AB3 ASP A  252  SER A  263  1                                  12    
HELIX   13 AB4 LYS A  279  ARG A  303  1                                  25    
HELIX   14 AB5 GLY A  324  GLN A  335  1                                  12    
HELIX   15 AB6 ASN A  411  LEU A  415  5                                   5    
HELIX   16 AB7 GLU A  416  GLU A  419  5                                   4    
HELIX   17 AB8 GLY A  423  CYS A  436  1                                  14    
HELIX   18 AB9 ASN A  461  TYR A  469  1                                   9    
HELIX   19 AC1 THR A  482  GLU A  487  1                                   6    
HELIX   20 AC2 VAL A  514  ASP A  519  1                                   6    
HELIX   21 AC3 ALA A  522  SER A  544  1                                  23    
HELIX   22 AC4 PHE A  574  MET A  585  1                                  12    
HELIX   23 AC5 GLY A  598  VAL A  630  1                                  33    
HELIX   24 AC6 SER A  635  LYS A  641  1                                   7    
HELIX   25 AC7 GLY A  653  ARG A  661  1                                   9    
HELIX   26 AC8 ILE A  664  ALA A  677  1                                  14    
HELIX   27 AC9 THR A  685  LYS A  697  1                                  13    
HELIX   28 AD1 SER A  706  GLN A  714  1                                   9    
HELIX   29 AD2 LEU A  742  GLN A  756  1                                  15    
HELIX   30 AD3 GLY A  757  TRP A  767  1                                  11    
HELIX   31 AD4 GLY A  774  GLU A  782  5                                   9    
HELIX   32 AD5 SER A  788  ALA A  820  1                                  33    
HELIX   33 AD6 ALA B   22  PHE B   36  1                                  15    
HELIX   34 AD7 ASN B   54  GLY B   69  1                                  16    
HELIX   35 AD8 ASP B   78  HIS B   93  1                                  16    
HELIX   36 AD9 LEU B  117  GLN B  129  1                                  13    
HELIX   37 AE1 ASP B  138  GLY B  142  5                                   5    
HELIX   38 AE2 LEU B  143  LYS B  156  1                                  14    
HELIX   39 AE3 ASP B  174  LYS B  187  1                                  14    
HELIX   40 AE4 GLU B  197  GLY B  212  1                                  16    
HELIX   41 AE5 ASN B  224  THR B  228  5                                   5    
HELIX   42 AE6 ASP B  231  GLN B  236  5                                   6    
HELIX   43 AE7 ASP B  252  SER B  263  1                                  12    
HELIX   44 AE8 LYS B  279  ARG B  303  1                                  25    
HELIX   45 AE9 TRP B  323  LYS B  334  1                                  12    
HELIX   46 AF1 GLU B  416  GLU B  419  5                                   4    
HELIX   47 AF2 GLY B  423  GLY B  437  1                                  15    
HELIX   48 AF3 ASN B  461  TYR B  469  1                                   9    
HELIX   49 AF4 THR B  482  GLU B  487  1                                   6    
HELIX   50 AF5 ALA B  522  SER B  544  1                                  23    
HELIX   51 AF6 PHE B  574  MET B  585  1                                  12    
HELIX   52 AF7 GLY B  598  VAL B  626  1                                  29    
HELIX   53 AF8 ALA B  636  GLN B  642  1                                   7    
HELIX   54 AF9 GLY B  653  ARG B  661  1                                   9    
HELIX   55 AG1 ILE B  664  ALA B  677  1                                  14    
HELIX   56 AG2 THR B  685  LYS B  697  1                                  13    
HELIX   57 AG3 SER B  706  ARG B  715  1                                  10    
HELIX   58 AG4 LEU B  742  GLN B  756  1                                  15    
HELIX   59 AG5 GLY B  757  TRP B  767  1                                  11    
HELIX   60 AG6 TYR B  768  GLY B  771  5                                   4    
HELIX   61 AG7 GLY B  774  LYS B  781  1                                   8    
HELIX   62 AG8 LEU B  789  TYR B  816  1                                  28    
HELIX   63 AG9 ALA C   22  PHE C   36  1                                  15    
HELIX   64 AH1 ASN C   54  GLY C   69  1                                  16    
HELIX   65 AH2 SER C   81  HIS C   93  1                                  13    
HELIX   66 AH3 LEU C  117  GLN C  129  1                                  13    
HELIX   67 AH4 LEU C  143  LYS C  156  1                                  14    
HELIX   68 AH5 GLY C  166  ILE C  168  5                                   3    
HELIX   69 AH6 ASP C  174  LEU C  186  1                                  13    
HELIX   70 AH7 GLU C  197  GLY C  212  1                                  16    
HELIX   71 AH8 GLY C  226  GLY C  230  5                                   5    
HELIX   72 AH9 ASP C  231  GLN C  236  5                                   6    
HELIX   73 AI1 ASP C  252  SER C  263  1                                  12    
HELIX   74 AI2 LYS C  279  ARG C  303  1                                  25    
HELIX   75 AI3 GLY C  324  VAL C  336  1                                  13    
HELIX   76 AI4 GLU C  416  GLU C  419  5                                   4    
HELIX   77 AI5 GLY C  423  GLY C  437  1                                  15    
HELIX   78 AI6 ASN C  461  TYR C  469  1                                   9    
HELIX   79 AI7 THR C  482  GLU C  487  1                                   6    
HELIX   80 AI8 VAL C  514  ASP C  519  5                                   6    
HELIX   81 AI9 ALA C  522  VAL C  543  1                                  22    
HELIX   82 AJ1 PHE C  574  MET C  585  1                                  12    
HELIX   83 AJ2 GLY C  598  VAL C  630  1                                  33    
HELIX   84 AJ3 SER C  635  GLN C  642  1                                   8    
HELIX   85 AJ4 GLY C  653  SER C  662  1                                  10    
HELIX   86 AJ5 ILE C  664  ALA C  677  1                                  14    
HELIX   87 AJ6 THR C  685  SER C  696  1                                  12    
HELIX   88 AJ7 SER C  706  GLN C  714  1                                   9    
HELIX   89 AJ8 LEU C  742  GLY C  757  1                                  16    
HELIX   90 AJ9 GLY C  757  TRP C  767  1                                  11    
HELIX   91 AK1 GLY C  774  GLU C  782  5                                   9    
HELIX   92 AK2 LEU C  789  ALA C  820  1                                  32    
HELIX   93 AK3 ALA D   22  PHE D   36  1                                  15    
HELIX   94 AK4 ASN D   54  GLY D   69  1                                  16    
HELIX   95 AK5 SER D   81  HIS D   93  1                                  13    
HELIX   96 AK6 LEU D  117  GLN D  129  1                                  13    
HELIX   97 AK7 ASP D  138  GLY D  142  5                                   5    
HELIX   98 AK8 LEU D  143  LYS D  156  1                                  14    
HELIX   99 AK9 ASP D  174  LYS D  187  1                                  14    
HELIX  100 AL1 GLU D  197  GLY D  212  1                                  16    
HELIX  101 AL2 ASP D  252  SER D  263  1                                  12    
HELIX  102 AL3 LYS D  279  GLN D  302  1                                  24    
HELIX  103 AL4 TRP D  323  LYS D  334  1                                  12    
HELIX  104 AL5 GLU D  416  GLU D  419  5                                   4    
HELIX  105 AL6 GLY D  423  GLY D  437  1                                  15    
HELIX  106 AL7 ASN D  461  TYR D  469  1                                   9    
HELIX  107 AL8 THR D  482  GLU D  487  1                                   6    
HELIX  108 AL9 GLY D  513  PHE D  517  5                                   5    
HELIX  109 AM1 ALA D  522  SER D  544  1                                  23    
HELIX  110 AM2 PHE D  574  MET D  585  1                                  12    
HELIX  111 AM3 SER D  597  VAL D  626  1                                  30    
HELIX  112 AM4 ALA D  636  GLN D  642  1                                   7    
HELIX  113 AM5 GLY D  653  SER D  662  1                                  10    
HELIX  114 AM6 ILE D  664  ALA D  677  1                                  14    
HELIX  115 AM7 THR D  685  LYS D  697  1                                  13    
HELIX  116 AM8 SER D  706  ARG D  715  1                                  10    
HELIX  117 AM9 LEU D  742  GLN D  756  1                                  15    
HELIX  118 AN1 GLY D  757  TRP D  767  1                                  11    
HELIX  119 AN2 TYR D  768  GLY D  771  5                                   4    
HELIX  120 AN3 GLY D  774  LYS D  781  1                                   8    
HELIX  121 AN4 LEU D  789  ASN D  791  5                                   3    
HELIX  122 AN5 VAL D  792  LYS D  817  1                                  26    
SHEET    1 AA1 2 ILE A  12  LEU A  17  0                                        
SHEET    2 AA1 2 LEU A  43  ASP A  48  1  O  THR A  44   N  ILE A  12           
SHEET    1 AA2 3 ILE A  73  PHE A  74  0                                        
SHEET    2 AA2 3 PHE A  96  THR A  98  1  O  ILE A  97   N  ILE A  73           
SHEET    3 AA2 3 ILE A 111  GLN A 112  1  O  ILE A 111   N  THR A  98           
SHEET    1 AA3 8 GLN A 159  ASN A 164  0                                        
SHEET    2 AA3 8 LYS A 132  TYR A 137  1  N  TYR A 135   O  THR A 161           
SHEET    3 AA3 8 ARG A 191  ASP A 195  1  O  ILE A 193   N  ALA A 134           
SHEET    4 AA3 8 HIS A 219  ILE A 222  1  O  ILE A 221   N  LEU A 194           
SHEET    5 AA3 8 GLU A 241  GLN A 246  1  O  SER A 243   N  ILE A 222           
SHEET    6 AA3 8 THR A 357  LYS A 364 -1  O  LEU A 363   N  VAL A 242           
SHEET    7 AA3 8 GLY A 367  SER A 375 -1  O  ARG A 369   N  GLU A 362           
SHEET    8 AA3 8 LYS A 379  LEU A 382 -1  O  VAL A 381   N  TYR A 373           
SHEET    1 AA4 2 GLN A 337  GLY A 340  0                                        
SHEET    2 AA4 2 GLY A 343  LYS A 346 -1  O  GLY A 343   N  GLY A 340           
SHEET    1 AA5 3 TYR A 440  ILE A 444  0                                        
SHEET    2 AA5 3 VAL A 395  THR A 399  1  N  VAL A 395   O  LYS A 441           
SHEET    3 AA5 3 ILE A 474  ALA A 475  1  O  ILE A 474   N  THR A 398           
SHEET    1 AA6 2 MET A 407  MET A 408  0                                        
SHEET    2 AA6 2 TYR A 421  GLU A 422 -1  O  GLU A 422   N  MET A 407           
SHEET    1 AA7 2 ASP A 490  PHE A 491  0                                        
SHEET    2 AA7 2 ALA A 735  THR A 736 -1  O  THR A 736   N  ASP A 490           
SHEET    1 AA8 2 MET A 496  LEU A 498  0                                        
SHEET    2 AA8 2 LYS A 730  TYR A 732 -1  O  LYS A 730   N  LEU A 498           
SHEET    1 AA9 4 ALA A 646  GLY A 648  0                                        
SHEET    2 AA9 4 TYR A 700  GLU A 705  1  O  ALA A 701   N  ALA A 646           
SHEET    3 AA9 4 ILE A 500  LYS A 505 -1  N  MET A 503   O  TYR A 702           
SHEET    4 AA9 4 THR A 720  VAL A 723 -1  O  MET A 721   N  ILE A 504           
SHEET    1 AB1 2 SER B  11  LEU B  17  0                                        
SHEET    2 AB1 2 ARG B  42  ASP B  48  1  O  THR B  44   N  ILE B  12           
SHEET    1 AB2 2 ILE B  73  PHE B  74  0                                        
SHEET    2 AB2 2 PHE B  96  ILE B  97  1  O  ILE B  97   N  ILE B  73           
SHEET    1 AB3 2 ALA B 134  TYR B 137  0                                        
SHEET    2 AB3 2 THR B 161  ASN B 164  1  O  ILE B 163   N  TYR B 137           
SHEET    1 AB4 6 ARG B 191  LEU B 194  0                                        
SHEET    2 AB4 6 HIS B 219  ILE B 222  1  O  HIS B 219   N  VAL B 192           
SHEET    3 AB4 6 GLU B 241  GLN B 246  1  O  GLU B 241   N  TYR B 220           
SHEET    4 AB4 6 THR B 357  GLU B 362 -1  O  MET B 361   N  GLY B 244           
SHEET    5 AB4 6 ARG B 369  SER B 375 -1  O  ARG B 369   N  GLU B 362           
SHEET    6 AB4 6 LYS B 379  LEU B 382 -1  O  VAL B 381   N  TYR B 373           
SHEET    1 AB5 2 GLU B 339  GLY B 340  0                                        
SHEET    2 AB5 2 GLY B 343  ASN B 344 -1  O  GLY B 343   N  GLY B 340           
SHEET    1 AB6 2 LYS B 346  PHE B 347  0                                        
SHEET    2 AB6 2 ARG B 353  ILE B 354 -1  O  ILE B 354   N  LYS B 346           
SHEET    1 AB7 3 LYS B 441  ILE B 444  0                                        
SHEET    2 AB7 3 VAL B 396  THR B 399  1  N  VAL B 397   O  THR B 443           
SHEET    3 AB7 3 ILE B 474  ALA B 475  1  O  ILE B 474   N  THR B 398           
SHEET    1 AB8 2 MET B 407  MET B 408  0                                        
SHEET    2 AB8 2 TYR B 421  GLU B 422 -1  O  GLU B 422   N  MET B 407           
SHEET    1 AB9 2 ILE B 489  PHE B 491  0                                        
SHEET    2 AB9 2 ALA B 735  PRO B 737 -1  O  THR B 736   N  ASP B 490           
SHEET    1 AC1 2 MET B 496  LEU B 498  0                                        
SHEET    2 AC1 2 LYS B 730  TYR B 732 -1  O  LYS B 730   N  LEU B 498           
SHEET    1 AC2 4 ALA B 646  GLY B 648  0                                        
SHEET    2 AC2 4 TYR B 700  GLU B 705  1  O  LEU B 703   N  GLY B 648           
SHEET    3 AC2 4 ILE B 500  LYS B 505 -1  N  MET B 503   O  TYR B 702           
SHEET    4 AC2 4 THR B 720  VAL B 723 -1  O  MET B 721   N  ILE B 504           
SHEET    1 AC3 2 SER C  11  GLN C  13  0                                        
SHEET    2 AC3 2 ARG C  42  THR C  44  1  O  ARG C  42   N  ILE C  12           
SHEET    1 AC4 2 LEU C  17  PHE C  18  0                                        
SHEET    2 AC4 2 ASP C  48  ASN C  49  1  O  ASP C  48   N  PHE C  18           
SHEET    1 AC5 3 ILE C  73  PHE C  74  0                                        
SHEET    2 AC5 3 PHE C  96  THR C  98  1  O  ILE C  97   N  ILE C  73           
SHEET    3 AC5 3 ILE C 111  GLN C 112  1  O  ILE C 111   N  PHE C  96           
SHEET    1 AC6 8 GLN C 159  ASN C 164  0                                        
SHEET    2 AC6 8 LYS C 132  TYR C 137  1  N  PHE C 133   O  GLN C 159           
SHEET    3 AC6 8 ARG C 191  ASP C 195  1  O  ILE C 193   N  ALA C 134           
SHEET    4 AC6 8 HIS C 219  ILE C 222  1  O  ILE C 221   N  LEU C 194           
SHEET    5 AC6 8 GLU C 241  GLN C 246  1  O  SER C 243   N  ILE C 222           
SHEET    6 AC6 8 THR C 357  GLU C 362 -1  O  MET C 361   N  GLY C 244           
SHEET    7 AC6 8 ARG C 369  SER C 375 -1  O  ARG C 369   N  GLU C 362           
SHEET    8 AC6 8 LYS C 379  LEU C 382 -1  O  VAL C 381   N  TYR C 373           
SHEET    1 AC7 3 GLN C 337  GLY C 340  0                                        
SHEET    2 AC7 3 GLY C 343  PHE C 347 -1  O  ILE C 345   N  VAL C 338           
SHEET    3 AC7 3 ARG C 353  ILE C 354 -1  O  ILE C 354   N  LYS C 346           
SHEET    1 AC8 3 TYR C 440  ILE C 444  0                                        
SHEET    2 AC8 3 VAL C 395  THR C 399  1  N  VAL C 397   O  THR C 443           
SHEET    3 AC8 3 ILE C 474  ALA C 475  1  O  ILE C 474   N  THR C 398           
SHEET    1 AC9 2 MET C 407  MET C 408  0                                        
SHEET    2 AC9 2 TYR C 421  GLU C 422 -1  O  GLU C 422   N  MET C 407           
SHEET    1 AD1 2 ASP C 490  PHE C 491  0                                        
SHEET    2 AD1 2 ALA C 735  THR C 736 -1  O  THR C 736   N  ASP C 490           
SHEET    1 AD2 2 MET C 496  LEU C 498  0                                        
SHEET    2 AD2 2 LYS C 730  TYR C 732 -1  O  LYS C 730   N  LEU C 498           
SHEET    1 AD3 4 ALA C 646  GLY C 648  0                                        
SHEET    2 AD3 4 TYR C 700  GLU C 705  1  O  ALA C 701   N  ALA C 646           
SHEET    3 AD3 4 ILE C 500  LYS C 505 -1  N  MET C 503   O  TYR C 702           
SHEET    4 AD3 4 THR C 720  VAL C 723 -1  O  MET C 721   N  ILE C 504           
SHEET    1 AD4 2 SER D  11  LEU D  17  0                                        
SHEET    2 AD4 2 ARG D  42  ASP D  48  1  O  THR D  44   N  ILE D  12           
SHEET    1 AD5 2 ILE D  73  PHE D  74  0                                        
SHEET    2 AD5 2 PHE D  96  ILE D  97  1  O  ILE D  97   N  ILE D  73           
SHEET    1 AD6 2 ALA D 134  TYR D 137  0                                        
SHEET    2 AD6 2 THR D 161  ASN D 164  1  O  THR D 161   N  TYR D 135           
SHEET    1 AD7 6 ARG D 191  LEU D 194  0                                        
SHEET    2 AD7 6 HIS D 219  ILE D 222  1  O  HIS D 219   N  VAL D 192           
SHEET    3 AD7 6 GLU D 241  GLN D 246  1  O  GLU D 241   N  TYR D 220           
SHEET    4 AD7 6 THR D 357  GLU D 362 -1  O  ASN D 359   N  GLN D 246           
SHEET    5 AD7 6 ARG D 369  SER D 375 -1  O  ARG D 369   N  GLU D 362           
SHEET    6 AD7 6 LYS D 379  LEU D 382 -1  O  VAL D 381   N  TYR D 373           
SHEET    1 AD8 2 GLU D 339  GLY D 340  0                                        
SHEET    2 AD8 2 GLY D 343  ASN D 344 -1  O  GLY D 343   N  GLY D 340           
SHEET    1 AD9 2 LYS D 346  PHE D 347  0                                        
SHEET    2 AD9 2 ARG D 353  ILE D 354 -1  O  ILE D 354   N  LYS D 346           
SHEET    1 AE1 3 LYS D 441  ILE D 444  0                                        
SHEET    2 AE1 3 VAL D 396  THR D 399  1  N  VAL D 397   O  THR D 443           
SHEET    3 AE1 3 ILE D 474  ALA D 475  1  O  ILE D 474   N  THR D 398           
SHEET    1 AE2 2 MET D 407  MET D 408  0                                        
SHEET    2 AE2 2 TYR D 421  GLU D 422 -1  O  GLU D 422   N  MET D 407           
SHEET    1 AE3 2 ILE D 489  PHE D 491  0                                        
SHEET    2 AE3 2 ALA D 735  PRO D 737 -1  O  THR D 736   N  ASP D 490           
SHEET    1 AE4 2 MET D 496  LEU D 498  0                                        
SHEET    2 AE4 2 LYS D 730  TYR D 732 -1  O  TYR D 732   N  MET D 496           
SHEET    1 AE5 4 ALA D 646  GLY D 648  0                                        
SHEET    2 AE5 4 TYR D 700  GLU D 705  1  O  LEU D 703   N  GLY D 648           
SHEET    3 AE5 4 ILE D 500  LYS D 505 -1  N  MET D 503   O  TYR D 702           
SHEET    4 AE5 4 THR D 720  VAL D 723 -1  O  MET D 721   N  ILE D 504           
SSBOND   1 CYS A   63    CYS A  315                          1555   1555  2.04  
SSBOND   2 CYS A  718    CYS A  773                          1555   1555  2.03  
SSBOND   3 CYS B   63    CYS B  315                          1555   1555  2.03  
SSBOND   4 CYS B  718    CYS B  773                          1555   1555  2.03  
SSBOND   5 CYS C   63    CYS C  315                          1555   1555  2.03  
SSBOND   6 CYS C  718    CYS C  773                          1555   1555  2.03  
SSBOND   7 CYS D   63    CYS D  315                          1555   1555  2.03  
SSBOND   8 CYS D  718    CYS D  773                          1555   1555  2.03  
LINK         SG  CYS B 718                 CB  CYS B 773     1555   1555  1.72  
CISPEP   1 ASN A  318    PRO A  319          0       -13.99                     
CISPEP   2 SER A  403    PRO A  404          0        -7.06                     
CISPEP   3 GLU A  678    PRO A  679          0        -3.80                     
CISPEP   4 LYS A  716    PRO A  717          0         1.78                     
CISPEP   5 ASN B  318    PRO B  319          0        -5.32                     
CISPEP   6 SER B  403    PRO B  404          0         0.89                     
CISPEP   7 GLU B  678    PRO B  679          0         0.55                     
CISPEP   8 LYS B  716    PRO B  717          0        -0.33                     
CISPEP   9 ASN C  318    PRO C  319          0       -11.34                     
CISPEP  10 SER C  403    PRO C  404          0        -4.60                     
CISPEP  11 GLU C  678    PRO C  679          0        -4.74                     
CISPEP  12 LYS C  716    PRO C  717          0         1.87                     
CISPEP  13 ASN D  318    PRO D  319          0        -7.58                     
CISPEP  14 SER D  403    PRO D  404          0        -0.23                     
CISPEP  15 GLU D  678    PRO D  679          0         0.09                     
CISPEP  16 LYS D  716    PRO D  717          0        -0.54                     
SITE     1 AC1 10 TYR A 450  PRO A 478  LEU A 479  THR A 480                    
SITE     2 AC1 10 ARG A 485  GLY A 653  SER A 654  THR A 686                    
SITE     3 AC1 10 GLU A 705  TYR A 732                                          
SITE     1 AC2  3 ASN A 344  LYS A 346  ASN A 355                               
SITE     1 AC3 11 GLU B 402  TYR B 450  PRO B 478  LEU B 479                    
SITE     2 AC3 11 THR B 480  ARG B 485  GLY B 653  SER B 654                    
SITE     3 AC3 11 THR B 686  GLU B 705  TYR B 732                               
SITE     1 AC4  4 GLN B 337  ASN B 344  LYS B 346  ASN B 355                    
SITE     1 AC5 10 TYR C 450  PRO C 478  LEU C 479  THR C 480                    
SITE     2 AC5 10 ARG C 485  GLY C 653  SER C 654  THR C 686                    
SITE     3 AC5 10 GLU C 705  TYR C 732                                          
SITE     1 AC6  3 ASN C 344  LYS C 346  ASN C 355                               
SITE     1 AC7 11 GLU D 402  TYR D 450  PRO D 478  LEU D 479                    
SITE     2 AC7 11 THR D 480  ARG D 485  GLY D 653  SER D 654                    
SITE     3 AC7 11 THR D 686  GLU D 705  TYR D 732                               
SITE     1 AC8  3 GLN D 337  ASN D 344  ASN D 355                               
CRYST1  374.400  374.400  374.400  90.00  90.00  90.00 P 1           4          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.002671  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.002671  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.002671        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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