HEADER MEMBRANE PROTEIN 03-AUG-17 5WP6
TITLE CRYO-EM STRUCTURE OF A HUMAN TRPM4 CHANNEL IN COMPLEX WITH CALCIUM AND
TITLE 2 DECAVANADATE
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M
COMPND 3 MEMBER 4;
COMPND 4 CHAIN: A, B, C, D;
COMPND 5 SYNONYM: HTRPM4,CALCIUM-ACTIVATED NON-SELECTIVE CATION CHANNEL 1,LONG
COMPND 6 TRANSIENT RECEPTOR POTENTIAL CHANNEL 4,LTRPC4,MELASTATIN-4;
COMPND 7 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: TRPM4, LTRPC4;
SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606
KEYWDS ION CHANNEL, MEMBRANE PROTEIN
EXPDTA ELECTRON MICROSCOPY
AUTHOR P.A.WINKLER,Y.HUANG,W.SUN,J.DU,W.LU
REVDAT 3 27-DEC-17 5WP6 1 JRNL
REVDAT 2 20-DEC-17 5WP6 1 JRNL
REVDAT 1 13-DEC-17 5WP6 0
JRNL AUTH P.A.WINKLER,Y.HUANG,W.SUN,J.DU,W.LU
JRNL TITL ELECTRON CRYO-MICROSCOPY STRUCTURE OF A HUMAN TRPM4 CHANNEL.
JRNL REF NATURE V. 552 200 2017
JRNL REFN ESSN 1476-4687
JRNL PMID 29211723
JRNL DOI 10.1038/NATURE24674
REMARK 2
REMARK 2 RESOLUTION. 3.80 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : NULL
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.800
REMARK 3 NUMBER OF PARTICLES : 121906
REMARK 3 CTF CORRECTION METHOD : NONE
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 5WP6 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-AUG-17.
REMARK 100 THE DEPOSITION ID IS D_1000229385.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : TRPM4
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 8.00
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 54.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 VAL A 2
REMARK 465 VAL A 3
REMARK 465 PRO A 4
REMARK 465 GLU A 5
REMARK 465 LYS A 6
REMARK 465 THR A 21
REMARK 465 THR A 22
REMARK 465 PHE A 23
REMARK 465 ILE A 24
REMARK 465 VAL A 25
REMARK 465 ASP A 26
REMARK 465 SER A 27
REMARK 465 THR A 28
REMARK 465 ASP A 29
REMARK 465 PRO A 30
REMARK 465 GLY A 31
REMARK 465 GLY A 32
REMARK 465 THR A 33
REMARK 465 LEU A 34
REMARK 465 CYS A 35
REMARK 465 GLN A 36
REMARK 465 CYS A 37
REMARK 465 GLY A 38
REMARK 465 ARG A 39
REMARK 465 PRO A 40
REMARK 465 ARG A 41
REMARK 465 THR A 42
REMARK 465 ALA A 43
REMARK 465 HIS A 44
REMARK 465 PRO A 45
REMARK 465 ALA A 46
REMARK 465 VAL A 47
REMARK 465 ALA A 48
REMARK 465 MET A 49
REMARK 465 GLU A 50
REMARK 465 ASP A 51
REMARK 465 ALA A 52
REMARK 465 PHE A 53
REMARK 465 GLY A 54
REMARK 465 ALA A 55
REMARK 465 ALA A 56
REMARK 465 VAL A 57
REMARK 465 VAL A 58
REMARK 465 THR A 59
REMARK 465 VAL A 60
REMARK 465 TRP A 61
REMARK 465 ASP A 62
REMARK 465 SER A 63
REMARK 465 ASP A 64
REMARK 465 ALA A 65
REMARK 465 ASP A 216
REMARK 465 PRO A 217
REMARK 465 GLU A 218
REMARK 465 ASP A 219
REMARK 465 GLY A 220
REMARK 465 LEU A 319
REMARK 465 ALA A 320
REMARK 465 PRO A 321
REMARK 465 GLY A 322
REMARK 465 SER A 323
REMARK 465 GLY A 324
REMARK 465 GLY A 325
REMARK 465 ALA A 326
REMARK 465 SER A 388
REMARK 465 GLU A 389
REMARK 465 ALA A 390
REMARK 465 SER A 391
REMARK 465 ALA A 392
REMARK 465 SER A 481
REMARK 465 HIS A 482
REMARK 465 SER A 483
REMARK 465 ALA A 484
REMARK 465 GLY A 485
REMARK 465 THR A 486
REMARK 465 LYS A 487
REMARK 465 ALA A 488
REMARK 465 PRO A 489
REMARK 465 ALA A 490
REMARK 465 LEU A 491
REMARK 465 LYS A 492
REMARK 465 GLY A 493
REMARK 465 GLY A 494
REMARK 465 ALA A 495
REMARK 465 ALA A 496
REMARK 465 GLU A 497
REMARK 465 LEU A 498
REMARK 465 ARG A 499
REMARK 465 PRO A 500
REMARK 465 PRO A 501
REMARK 465 ASP A 502
REMARK 465 VAL A 503
REMARK 465 GLY A 504
REMARK 465 HIS A 505
REMARK 465 VAL A 506
REMARK 465 LEU A 507
REMARK 465 ARG A 508
REMARK 465 MET A 509
REMARK 465 LEU A 510
REMARK 465 LEU A 511
REMARK 465 GLY A 512
REMARK 465 LYS A 513
REMARK 465 MET A 514
REMARK 465 CYS A 515
REMARK 465 ALA A 516
REMARK 465 PRO A 517
REMARK 465 ARG A 518
REMARK 465 TYR A 519
REMARK 465 PRO A 520
REMARK 465 SER A 521
REMARK 465 GLY A 522
REMARK 465 GLY A 523
REMARK 465 ALA A 524
REMARK 465 TRP A 525
REMARK 465 ASP A 526
REMARK 465 PRO A 527
REMARK 465 HIS A 528
REMARK 465 PRO A 529
REMARK 465 GLY A 530
REMARK 465 GLN A 531
REMARK 465 GLY A 532
REMARK 465 PHE A 533
REMARK 465 GLY A 534
REMARK 465 GLU A 535
REMARK 465 SER A 536
REMARK 465 MET A 537
REMARK 465 TYR A 538
REMARK 465 LEU A 539
REMARK 465 LEU A 540
REMARK 465 SER A 541
REMARK 465 ASP A 542
REMARK 465 LYS A 543
REMARK 465 ALA A 544
REMARK 465 THR A 545
REMARK 465 SER A 546
REMARK 465 PRO A 547
REMARK 465 LEU A 548
REMARK 465 SER A 549
REMARK 465 LEU A 550
REMARK 465 ASP A 551
REMARK 465 ALA A 552
REMARK 465 GLY A 553
REMARK 465 LEU A 554
REMARK 465 GLY A 555
REMARK 465 GLN A 556
REMARK 465 ALA A 557
REMARK 465 ARG A 711
REMARK 465 LYS A 712
REMARK 465 SER A 713
REMARK 465 GLU A 714
REMARK 465 GLU A 715
REMARK 465 GLU A 716
REMARK 465 PRO A 717
REMARK 465 THR A 718
REMARK 465 ARG A 719
REMARK 465 GLU A 720
REMARK 465 GLU A 721
REMARK 465 LEU A 722
REMARK 465 GLU A 723
REMARK 465 PHE A 724
REMARK 465 ASP A 725
REMARK 465 MET A 726
REMARK 465 ASP A 727
REMARK 465 SER A 728
REMARK 465 VAL A 729
REMARK 465 ILE A 730
REMARK 465 ASN A 731
REMARK 465 GLY A 732
REMARK 465 GLU A 733
REMARK 465 GLY A 734
REMARK 465 PRO A 735
REMARK 465 VAL A 736
REMARK 465 GLY A 737
REMARK 465 THR A 738
REMARK 465 ALA A 739
REMARK 465 ASP A 740
REMARK 465 PRO A 741
REMARK 465 ALA A 742
REMARK 465 GLU A 743
REMARK 465 LYS A 744
REMARK 465 THR A 745
REMARK 465 PRO A 746
REMARK 465 LEU A 747
REMARK 465 GLY A 748
REMARK 465 VAL A 749
REMARK 465 PRO A 750
REMARK 465 ARG A 751
REMARK 465 GLN A 752
REMARK 465 SER A 753
REMARK 465 GLY A 754
REMARK 465 ARG A 755
REMARK 465 PRO A 756
REMARK 465 GLY A 757
REMARK 465 CYS A 758
REMARK 465 CYS A 759
REMARK 465 GLY A 760
REMARK 465 GLY A 761
REMARK 465 ARG A 762
REMARK 465 CYS A 763
REMARK 465 GLY A 764
REMARK 465 GLY A 765
REMARK 465 GLY A 836
REMARK 465 GLY A 837
REMARK 465 LEU A 1092
REMARK 465 CYS A 1093
REMARK 465 ARG A 1094
REMARK 465 ARG A 1095
REMARK 465 PRO A 1096
REMARK 465 ARG A 1097
REMARK 465 SER A 1098
REMARK 465 PRO A 1099
REMARK 465 GLN A 1100
REMARK 465 PRO A 1101
REMARK 465 SER A 1102
REMARK 465 SER A 1103
REMARK 465 PRO A 1104
REMARK 465 SER A 1194
REMARK 465 ARG A 1195
REMARK 465 SER A 1196
REMARK 465 ALA A 1197
REMARK 465 LEU A 1198
REMARK 465 LEU A 1199
REMARK 465 PRO A 1200
REMARK 465 PRO A 1201
REMARK 465 GLY A 1202
REMARK 465 GLY A 1203
REMARK 465 PRO A 1204
REMARK 465 PRO A 1205
REMARK 465 PRO A 1206
REMARK 465 PRO A 1207
REMARK 465 ASP A 1208
REMARK 465 LEU A 1209
REMARK 465 PRO A 1210
REMARK 465 GLY A 1211
REMARK 465 SER A 1212
REMARK 465 LYS A 1213
REMARK 465 ASP A 1214
REMARK 465 MET B 1
REMARK 465 VAL B 2
REMARK 465 VAL B 3
REMARK 465 PRO B 4
REMARK 465 GLU B 5
REMARK 465 LYS B 6
REMARK 465 THR B 21
REMARK 465 THR B 22
REMARK 465 PHE B 23
REMARK 465 ILE B 24
REMARK 465 VAL B 25
REMARK 465 ASP B 26
REMARK 465 SER B 27
REMARK 465 THR B 28
REMARK 465 ASP B 29
REMARK 465 PRO B 30
REMARK 465 GLY B 31
REMARK 465 GLY B 32
REMARK 465 THR B 33
REMARK 465 LEU B 34
REMARK 465 CYS B 35
REMARK 465 GLN B 36
REMARK 465 CYS B 37
REMARK 465 GLY B 38
REMARK 465 ARG B 39
REMARK 465 PRO B 40
REMARK 465 ARG B 41
REMARK 465 THR B 42
REMARK 465 ALA B 43
REMARK 465 HIS B 44
REMARK 465 PRO B 45
REMARK 465 ALA B 46
REMARK 465 VAL B 47
REMARK 465 ALA B 48
REMARK 465 MET B 49
REMARK 465 GLU B 50
REMARK 465 ASP B 51
REMARK 465 ALA B 52
REMARK 465 PHE B 53
REMARK 465 GLY B 54
REMARK 465 ALA B 55
REMARK 465 ALA B 56
REMARK 465 VAL B 57
REMARK 465 VAL B 58
REMARK 465 THR B 59
REMARK 465 VAL B 60
REMARK 465 TRP B 61
REMARK 465 ASP B 62
REMARK 465 SER B 63
REMARK 465 ASP B 64
REMARK 465 ALA B 65
REMARK 465 ASP B 216
REMARK 465 PRO B 217
REMARK 465 GLU B 218
REMARK 465 ASP B 219
REMARK 465 GLY B 220
REMARK 465 LEU B 319
REMARK 465 ALA B 320
REMARK 465 PRO B 321
REMARK 465 GLY B 322
REMARK 465 SER B 323
REMARK 465 GLY B 324
REMARK 465 GLY B 325
REMARK 465 ALA B 326
REMARK 465 SER B 388
REMARK 465 GLU B 389
REMARK 465 ALA B 390
REMARK 465 SER B 391
REMARK 465 ALA B 392
REMARK 465 SER B 481
REMARK 465 HIS B 482
REMARK 465 SER B 483
REMARK 465 ALA B 484
REMARK 465 GLY B 485
REMARK 465 THR B 486
REMARK 465 LYS B 487
REMARK 465 ALA B 488
REMARK 465 PRO B 489
REMARK 465 ALA B 490
REMARK 465 LEU B 491
REMARK 465 LYS B 492
REMARK 465 GLY B 493
REMARK 465 GLY B 494
REMARK 465 ALA B 495
REMARK 465 ALA B 496
REMARK 465 GLU B 497
REMARK 465 LEU B 498
REMARK 465 ARG B 499
REMARK 465 PRO B 500
REMARK 465 PRO B 501
REMARK 465 ASP B 502
REMARK 465 VAL B 503
REMARK 465 GLY B 504
REMARK 465 HIS B 505
REMARK 465 VAL B 506
REMARK 465 LEU B 507
REMARK 465 ARG B 508
REMARK 465 MET B 509
REMARK 465 LEU B 510
REMARK 465 LEU B 511
REMARK 465 GLY B 512
REMARK 465 LYS B 513
REMARK 465 MET B 514
REMARK 465 CYS B 515
REMARK 465 ALA B 516
REMARK 465 PRO B 517
REMARK 465 ARG B 518
REMARK 465 TYR B 519
REMARK 465 PRO B 520
REMARK 465 SER B 521
REMARK 465 GLY B 522
REMARK 465 GLY B 523
REMARK 465 ALA B 524
REMARK 465 TRP B 525
REMARK 465 ASP B 526
REMARK 465 PRO B 527
REMARK 465 HIS B 528
REMARK 465 PRO B 529
REMARK 465 GLY B 530
REMARK 465 GLN B 531
REMARK 465 GLY B 532
REMARK 465 PHE B 533
REMARK 465 GLY B 534
REMARK 465 GLU B 535
REMARK 465 SER B 536
REMARK 465 MET B 537
REMARK 465 TYR B 538
REMARK 465 LEU B 539
REMARK 465 LEU B 540
REMARK 465 SER B 541
REMARK 465 ASP B 542
REMARK 465 LYS B 543
REMARK 465 ALA B 544
REMARK 465 THR B 545
REMARK 465 SER B 546
REMARK 465 PRO B 547
REMARK 465 LEU B 548
REMARK 465 SER B 549
REMARK 465 LEU B 550
REMARK 465 ASP B 551
REMARK 465 ALA B 552
REMARK 465 GLY B 553
REMARK 465 LEU B 554
REMARK 465 GLY B 555
REMARK 465 GLN B 556
REMARK 465 ALA B 557
REMARK 465 ARG B 711
REMARK 465 LYS B 712
REMARK 465 SER B 713
REMARK 465 GLU B 714
REMARK 465 GLU B 715
REMARK 465 GLU B 716
REMARK 465 PRO B 717
REMARK 465 THR B 718
REMARK 465 ARG B 719
REMARK 465 GLU B 720
REMARK 465 GLU B 721
REMARK 465 LEU B 722
REMARK 465 GLU B 723
REMARK 465 PHE B 724
REMARK 465 ASP B 725
REMARK 465 MET B 726
REMARK 465 ASP B 727
REMARK 465 SER B 728
REMARK 465 VAL B 729
REMARK 465 ILE B 730
REMARK 465 ASN B 731
REMARK 465 GLY B 732
REMARK 465 GLU B 733
REMARK 465 GLY B 734
REMARK 465 PRO B 735
REMARK 465 VAL B 736
REMARK 465 GLY B 737
REMARK 465 THR B 738
REMARK 465 ALA B 739
REMARK 465 ASP B 740
REMARK 465 PRO B 741
REMARK 465 ALA B 742
REMARK 465 GLU B 743
REMARK 465 LYS B 744
REMARK 465 THR B 745
REMARK 465 PRO B 746
REMARK 465 LEU B 747
REMARK 465 GLY B 748
REMARK 465 VAL B 749
REMARK 465 PRO B 750
REMARK 465 ARG B 751
REMARK 465 GLN B 752
REMARK 465 SER B 753
REMARK 465 GLY B 754
REMARK 465 ARG B 755
REMARK 465 PRO B 756
REMARK 465 GLY B 757
REMARK 465 CYS B 758
REMARK 465 CYS B 759
REMARK 465 GLY B 760
REMARK 465 GLY B 761
REMARK 465 ARG B 762
REMARK 465 CYS B 763
REMARK 465 GLY B 764
REMARK 465 GLY B 765
REMARK 465 GLY B 836
REMARK 465 GLY B 837
REMARK 465 LEU B 1092
REMARK 465 CYS B 1093
REMARK 465 ARG B 1094
REMARK 465 ARG B 1095
REMARK 465 PRO B 1096
REMARK 465 ARG B 1097
REMARK 465 SER B 1098
REMARK 465 PRO B 1099
REMARK 465 GLN B 1100
REMARK 465 PRO B 1101
REMARK 465 SER B 1102
REMARK 465 SER B 1103
REMARK 465 PRO B 1104
REMARK 465 SER B 1194
REMARK 465 ARG B 1195
REMARK 465 SER B 1196
REMARK 465 ALA B 1197
REMARK 465 LEU B 1198
REMARK 465 LEU B 1199
REMARK 465 PRO B 1200
REMARK 465 PRO B 1201
REMARK 465 GLY B 1202
REMARK 465 GLY B 1203
REMARK 465 PRO B 1204
REMARK 465 PRO B 1205
REMARK 465 PRO B 1206
REMARK 465 PRO B 1207
REMARK 465 ASP B 1208
REMARK 465 LEU B 1209
REMARK 465 PRO B 1210
REMARK 465 GLY B 1211
REMARK 465 SER B 1212
REMARK 465 LYS B 1213
REMARK 465 ASP B 1214
REMARK 465 MET C 1
REMARK 465 VAL C 2
REMARK 465 VAL C 3
REMARK 465 PRO C 4
REMARK 465 GLU C 5
REMARK 465 LYS C 6
REMARK 465 THR C 21
REMARK 465 THR C 22
REMARK 465 PHE C 23
REMARK 465 ILE C 24
REMARK 465 VAL C 25
REMARK 465 ASP C 26
REMARK 465 SER C 27
REMARK 465 THR C 28
REMARK 465 ASP C 29
REMARK 465 PRO C 30
REMARK 465 GLY C 31
REMARK 465 GLY C 32
REMARK 465 THR C 33
REMARK 465 LEU C 34
REMARK 465 CYS C 35
REMARK 465 GLN C 36
REMARK 465 CYS C 37
REMARK 465 GLY C 38
REMARK 465 ARG C 39
REMARK 465 PRO C 40
REMARK 465 ARG C 41
REMARK 465 THR C 42
REMARK 465 ALA C 43
REMARK 465 HIS C 44
REMARK 465 PRO C 45
REMARK 465 ALA C 46
REMARK 465 VAL C 47
REMARK 465 ALA C 48
REMARK 465 MET C 49
REMARK 465 GLU C 50
REMARK 465 ASP C 51
REMARK 465 ALA C 52
REMARK 465 PHE C 53
REMARK 465 GLY C 54
REMARK 465 ALA C 55
REMARK 465 ALA C 56
REMARK 465 VAL C 57
REMARK 465 VAL C 58
REMARK 465 THR C 59
REMARK 465 VAL C 60
REMARK 465 TRP C 61
REMARK 465 ASP C 62
REMARK 465 SER C 63
REMARK 465 ASP C 64
REMARK 465 ALA C 65
REMARK 465 ASP C 216
REMARK 465 PRO C 217
REMARK 465 GLU C 218
REMARK 465 ASP C 219
REMARK 465 GLY C 220
REMARK 465 LEU C 319
REMARK 465 ALA C 320
REMARK 465 PRO C 321
REMARK 465 GLY C 322
REMARK 465 SER C 323
REMARK 465 GLY C 324
REMARK 465 GLY C 325
REMARK 465 ALA C 326
REMARK 465 SER C 388
REMARK 465 GLU C 389
REMARK 465 ALA C 390
REMARK 465 SER C 391
REMARK 465 ALA C 392
REMARK 465 SER C 481
REMARK 465 HIS C 482
REMARK 465 SER C 483
REMARK 465 ALA C 484
REMARK 465 GLY C 485
REMARK 465 THR C 486
REMARK 465 LYS C 487
REMARK 465 ALA C 488
REMARK 465 PRO C 489
REMARK 465 ALA C 490
REMARK 465 LEU C 491
REMARK 465 LYS C 492
REMARK 465 GLY C 493
REMARK 465 GLY C 494
REMARK 465 ALA C 495
REMARK 465 ALA C 496
REMARK 465 GLU C 497
REMARK 465 LEU C 498
REMARK 465 ARG C 499
REMARK 465 PRO C 500
REMARK 465 PRO C 501
REMARK 465 ASP C 502
REMARK 465 VAL C 503
REMARK 465 GLY C 504
REMARK 465 HIS C 505
REMARK 465 VAL C 506
REMARK 465 LEU C 507
REMARK 465 ARG C 508
REMARK 465 MET C 509
REMARK 465 LEU C 510
REMARK 465 LEU C 511
REMARK 465 GLY C 512
REMARK 465 LYS C 513
REMARK 465 MET C 514
REMARK 465 CYS C 515
REMARK 465 ALA C 516
REMARK 465 PRO C 517
REMARK 465 ARG C 518
REMARK 465 TYR C 519
REMARK 465 PRO C 520
REMARK 465 SER C 521
REMARK 465 GLY C 522
REMARK 465 GLY C 523
REMARK 465 ALA C 524
REMARK 465 TRP C 525
REMARK 465 ASP C 526
REMARK 465 PRO C 527
REMARK 465 HIS C 528
REMARK 465 PRO C 529
REMARK 465 GLY C 530
REMARK 465 GLN C 531
REMARK 465 GLY C 532
REMARK 465 PHE C 533
REMARK 465 GLY C 534
REMARK 465 GLU C 535
REMARK 465 SER C 536
REMARK 465 MET C 537
REMARK 465 TYR C 538
REMARK 465 LEU C 539
REMARK 465 LEU C 540
REMARK 465 SER C 541
REMARK 465 ASP C 542
REMARK 465 LYS C 543
REMARK 465 ALA C 544
REMARK 465 THR C 545
REMARK 465 SER C 546
REMARK 465 PRO C 547
REMARK 465 LEU C 548
REMARK 465 SER C 549
REMARK 465 LEU C 550
REMARK 465 ASP C 551
REMARK 465 ALA C 552
REMARK 465 GLY C 553
REMARK 465 LEU C 554
REMARK 465 GLY C 555
REMARK 465 GLN C 556
REMARK 465 ALA C 557
REMARK 465 ARG C 711
REMARK 465 LYS C 712
REMARK 465 SER C 713
REMARK 465 GLU C 714
REMARK 465 GLU C 715
REMARK 465 GLU C 716
REMARK 465 PRO C 717
REMARK 465 THR C 718
REMARK 465 ARG C 719
REMARK 465 GLU C 720
REMARK 465 GLU C 721
REMARK 465 LEU C 722
REMARK 465 GLU C 723
REMARK 465 PHE C 724
REMARK 465 ASP C 725
REMARK 465 MET C 726
REMARK 465 ASP C 727
REMARK 465 SER C 728
REMARK 465 VAL C 729
REMARK 465 ILE C 730
REMARK 465 ASN C 731
REMARK 465 GLY C 732
REMARK 465 GLU C 733
REMARK 465 GLY C 734
REMARK 465 PRO C 735
REMARK 465 VAL C 736
REMARK 465 GLY C 737
REMARK 465 THR C 738
REMARK 465 ALA C 739
REMARK 465 ASP C 740
REMARK 465 PRO C 741
REMARK 465 ALA C 742
REMARK 465 GLU C 743
REMARK 465 LYS C 744
REMARK 465 THR C 745
REMARK 465 PRO C 746
REMARK 465 LEU C 747
REMARK 465 GLY C 748
REMARK 465 VAL C 749
REMARK 465 PRO C 750
REMARK 465 ARG C 751
REMARK 465 GLN C 752
REMARK 465 SER C 753
REMARK 465 GLY C 754
REMARK 465 ARG C 755
REMARK 465 PRO C 756
REMARK 465 GLY C 757
REMARK 465 CYS C 758
REMARK 465 CYS C 759
REMARK 465 GLY C 760
REMARK 465 GLY C 761
REMARK 465 ARG C 762
REMARK 465 CYS C 763
REMARK 465 GLY C 764
REMARK 465 GLY C 765
REMARK 465 GLY C 836
REMARK 465 GLY C 837
REMARK 465 LEU C 1092
REMARK 465 CYS C 1093
REMARK 465 ARG C 1094
REMARK 465 ARG C 1095
REMARK 465 PRO C 1096
REMARK 465 ARG C 1097
REMARK 465 SER C 1098
REMARK 465 PRO C 1099
REMARK 465 GLN C 1100
REMARK 465 PRO C 1101
REMARK 465 SER C 1102
REMARK 465 SER C 1103
REMARK 465 PRO C 1104
REMARK 465 SER C 1194
REMARK 465 ARG C 1195
REMARK 465 SER C 1196
REMARK 465 ALA C 1197
REMARK 465 LEU C 1198
REMARK 465 LEU C 1199
REMARK 465 PRO C 1200
REMARK 465 PRO C 1201
REMARK 465 GLY C 1202
REMARK 465 GLY C 1203
REMARK 465 PRO C 1204
REMARK 465 PRO C 1205
REMARK 465 PRO C 1206
REMARK 465 PRO C 1207
REMARK 465 ASP C 1208
REMARK 465 LEU C 1209
REMARK 465 PRO C 1210
REMARK 465 GLY C 1211
REMARK 465 SER C 1212
REMARK 465 LYS C 1213
REMARK 465 ASP C 1214
REMARK 465 MET D 1
REMARK 465 VAL D 2
REMARK 465 VAL D 3
REMARK 465 PRO D 4
REMARK 465 GLU D 5
REMARK 465 LYS D 6
REMARK 465 THR D 21
REMARK 465 THR D 22
REMARK 465 PHE D 23
REMARK 465 ILE D 24
REMARK 465 VAL D 25
REMARK 465 ASP D 26
REMARK 465 SER D 27
REMARK 465 THR D 28
REMARK 465 ASP D 29
REMARK 465 PRO D 30
REMARK 465 GLY D 31
REMARK 465 GLY D 32
REMARK 465 THR D 33
REMARK 465 LEU D 34
REMARK 465 CYS D 35
REMARK 465 GLN D 36
REMARK 465 CYS D 37
REMARK 465 GLY D 38
REMARK 465 ARG D 39
REMARK 465 PRO D 40
REMARK 465 ARG D 41
REMARK 465 THR D 42
REMARK 465 ALA D 43
REMARK 465 HIS D 44
REMARK 465 PRO D 45
REMARK 465 ALA D 46
REMARK 465 VAL D 47
REMARK 465 ALA D 48
REMARK 465 MET D 49
REMARK 465 GLU D 50
REMARK 465 ASP D 51
REMARK 465 ALA D 52
REMARK 465 PHE D 53
REMARK 465 GLY D 54
REMARK 465 ALA D 55
REMARK 465 ALA D 56
REMARK 465 VAL D 57
REMARK 465 VAL D 58
REMARK 465 THR D 59
REMARK 465 VAL D 60
REMARK 465 TRP D 61
REMARK 465 ASP D 62
REMARK 465 SER D 63
REMARK 465 ASP D 64
REMARK 465 ALA D 65
REMARK 465 ASP D 216
REMARK 465 PRO D 217
REMARK 465 GLU D 218
REMARK 465 ASP D 219
REMARK 465 GLY D 220
REMARK 465 LEU D 319
REMARK 465 ALA D 320
REMARK 465 PRO D 321
REMARK 465 GLY D 322
REMARK 465 SER D 323
REMARK 465 GLY D 324
REMARK 465 GLY D 325
REMARK 465 ALA D 326
REMARK 465 SER D 388
REMARK 465 GLU D 389
REMARK 465 ALA D 390
REMARK 465 SER D 391
REMARK 465 ALA D 392
REMARK 465 SER D 481
REMARK 465 HIS D 482
REMARK 465 SER D 483
REMARK 465 ALA D 484
REMARK 465 GLY D 485
REMARK 465 THR D 486
REMARK 465 LYS D 487
REMARK 465 ALA D 488
REMARK 465 PRO D 489
REMARK 465 ALA D 490
REMARK 465 LEU D 491
REMARK 465 LYS D 492
REMARK 465 GLY D 493
REMARK 465 GLY D 494
REMARK 465 ALA D 495
REMARK 465 ALA D 496
REMARK 465 GLU D 497
REMARK 465 LEU D 498
REMARK 465 ARG D 499
REMARK 465 PRO D 500
REMARK 465 PRO D 501
REMARK 465 ASP D 502
REMARK 465 VAL D 503
REMARK 465 GLY D 504
REMARK 465 HIS D 505
REMARK 465 VAL D 506
REMARK 465 LEU D 507
REMARK 465 ARG D 508
REMARK 465 MET D 509
REMARK 465 LEU D 510
REMARK 465 LEU D 511
REMARK 465 GLY D 512
REMARK 465 LYS D 513
REMARK 465 MET D 514
REMARK 465 CYS D 515
REMARK 465 ALA D 516
REMARK 465 PRO D 517
REMARK 465 ARG D 518
REMARK 465 TYR D 519
REMARK 465 PRO D 520
REMARK 465 SER D 521
REMARK 465 GLY D 522
REMARK 465 GLY D 523
REMARK 465 ALA D 524
REMARK 465 TRP D 525
REMARK 465 ASP D 526
REMARK 465 PRO D 527
REMARK 465 HIS D 528
REMARK 465 PRO D 529
REMARK 465 GLY D 530
REMARK 465 GLN D 531
REMARK 465 GLY D 532
REMARK 465 PHE D 533
REMARK 465 GLY D 534
REMARK 465 GLU D 535
REMARK 465 SER D 536
REMARK 465 MET D 537
REMARK 465 TYR D 538
REMARK 465 LEU D 539
REMARK 465 LEU D 540
REMARK 465 SER D 541
REMARK 465 ASP D 542
REMARK 465 LYS D 543
REMARK 465 ALA D 544
REMARK 465 THR D 545
REMARK 465 SER D 546
REMARK 465 PRO D 547
REMARK 465 LEU D 548
REMARK 465 SER D 549
REMARK 465 LEU D 550
REMARK 465 ASP D 551
REMARK 465 ALA D 552
REMARK 465 GLY D 553
REMARK 465 LEU D 554
REMARK 465 GLY D 555
REMARK 465 GLN D 556
REMARK 465 ALA D 557
REMARK 465 ARG D 711
REMARK 465 LYS D 712
REMARK 465 SER D 713
REMARK 465 GLU D 714
REMARK 465 GLU D 715
REMARK 465 GLU D 716
REMARK 465 PRO D 717
REMARK 465 THR D 718
REMARK 465 ARG D 719
REMARK 465 GLU D 720
REMARK 465 GLU D 721
REMARK 465 LEU D 722
REMARK 465 GLU D 723
REMARK 465 PHE D 724
REMARK 465 ASP D 725
REMARK 465 MET D 726
REMARK 465 ASP D 727
REMARK 465 SER D 728
REMARK 465 VAL D 729
REMARK 465 ILE D 730
REMARK 465 ASN D 731
REMARK 465 GLY D 732
REMARK 465 GLU D 733
REMARK 465 GLY D 734
REMARK 465 PRO D 735
REMARK 465 VAL D 736
REMARK 465 GLY D 737
REMARK 465 THR D 738
REMARK 465 ALA D 739
REMARK 465 ASP D 740
REMARK 465 PRO D 741
REMARK 465 ALA D 742
REMARK 465 GLU D 743
REMARK 465 LYS D 744
REMARK 465 THR D 745
REMARK 465 PRO D 746
REMARK 465 LEU D 747
REMARK 465 GLY D 748
REMARK 465 VAL D 749
REMARK 465 PRO D 750
REMARK 465 ARG D 751
REMARK 465 GLN D 752
REMARK 465 SER D 753
REMARK 465 GLY D 754
REMARK 465 ARG D 755
REMARK 465 PRO D 756
REMARK 465 GLY D 757
REMARK 465 CYS D 758
REMARK 465 CYS D 759
REMARK 465 GLY D 760
REMARK 465 GLY D 761
REMARK 465 ARG D 762
REMARK 465 CYS D 763
REMARK 465 GLY D 764
REMARK 465 GLY D 765
REMARK 465 GLY D 836
REMARK 465 GLY D 837
REMARK 465 LEU D 1092
REMARK 465 CYS D 1093
REMARK 465 ARG D 1094
REMARK 465 ARG D 1095
REMARK 465 PRO D 1096
REMARK 465 ARG D 1097
REMARK 465 SER D 1098
REMARK 465 PRO D 1099
REMARK 465 GLN D 1100
REMARK 465 PRO D 1101
REMARK 465 SER D 1102
REMARK 465 SER D 1103
REMARK 465 PRO D 1104
REMARK 465 SER D 1194
REMARK 465 ARG D 1195
REMARK 465 SER D 1196
REMARK 465 ALA D 1197
REMARK 465 LEU D 1198
REMARK 465 LEU D 1199
REMARK 465 PRO D 1200
REMARK 465 PRO D 1201
REMARK 465 GLY D 1202
REMARK 465 GLY D 1203
REMARK 465 PRO D 1204
REMARK 465 PRO D 1205
REMARK 465 PRO D 1206
REMARK 465 PRO D 1207
REMARK 465 ASP D 1208
REMARK 465 LEU D 1209
REMARK 465 PRO D 1210
REMARK 465 GLY D 1211
REMARK 465 SER D 1212
REMARK 465 LYS D 1213
REMARK 465 ASP D 1214
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 GLU A 7 CG CD OE1 OE2
REMARK 470 LYS A 13 CG CD CE NZ
REMARK 470 CYS A 20 O SG
REMARK 470 HIS A 66 CG ND1 CD2 CE1 NE2
REMARK 470 THR A 68 OG1 CG2
REMARK 470 GLU A 69 CG CD OE1 OE2
REMARK 470 GLU A 77 CG CD OE1 OE2
REMARK 470 ARG A 85 CG CD NE CZ NH1 NH2
REMARK 470 LYS A 86 CG CD CE NZ
REMARK 470 ARG A 96 CG CD NE CZ NH1 NH2
REMARK 470 ASP A 98 CG OD1 OD2
REMARK 470 ARG A 108 CG CD NE CZ NH1 NH2
REMARK 470 ARG A 113 CG CD NE CZ NH1 NH2
REMARK 470 SER A 125 OG
REMARK 470 ASP A 172 CG OD1 OD2
REMARK 470 MET A 175 CG SD CE
REMARK 470 LYS A 182 CG CD CE NZ
REMARK 470 ASP A 198 CG OD1 OD2
REMARK 470 ASN A 202 CG OD1 ND2
REMARK 470 LYS A 204 CG CD CE NZ
REMARK 470 SER A 206 OG
REMARK 470 ARG A 210 CG CD NE CZ NH1 NH2
REMARK 470 ASP A 237 CG OD1 OD2
REMARK 470 CYS A 242 SG
REMARK 470 LEU A 243 CG CD1 CD2
REMARK 470 THR A 267 OG1 CG2
REMARK 470 ASP A 281 CG OD1 OD2
REMARK 470 GLU A 282 CG CD OE1 OE2
REMARK 470 LYS A 283 CG CD CE NZ
REMARK 470 GLU A 289 CG CD OE1 OE2
REMARK 470 THR A 292 OG1 CG2
REMARK 470 GLN A 295 CG CD OE1 NE2
REMARK 470 CYS A 298 SG
REMARK 470 GLU A 316 CG CD OE1 OE2
REMARK 470 ASP A 317 CG OD1 OD2
REMARK 470 THR A 318 O OG1 CG2
REMARK 470 ARG A 327 CG CD NE CZ NH1 NH2
REMARK 470 ARG A 334 CG CD NE CZ NH1 NH2
REMARK 470 ILE A 335 CG1 CG2 CD1
REMARK 470 ARG A 336 CG CD NE CZ NH1 NH2
REMARK 470 ARG A 337 CG CD NE CZ NH1 NH2
REMARK 470 PHE A 338 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 PHE A 339 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LYS A 341 CG CD CE NZ
REMARK 470 LEU A 344 CG CD1 CD2
REMARK 470 GLU A 345 CG CD OE1 OE2
REMARK 470 GLN A 348 CG CD OE1 NE2
REMARK 470 GLN A 350 CG CD OE1 NE2
REMARK 470 GLU A 352 CG CD OE1 OE2
REMARK 470 LYS A 358 CG CD CE NZ
REMARK 470 GLU A 359 CG CD OE1 OE2
REMARK 470 GLU A 367 CG CD OE1 OE2
REMARK 470 ASP A 368 CG OD1 OD2
REMARK 470 SER A 370 OG
REMARK 470 GLU A 371 CG CD OE1 OE2
REMARK 470 GLU A 372 CG CD OE1 OE2
REMARK 470 CYS A 385 SG
REMARK 470 SER A 387 O OG
REMARK 470 TYR A 393 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 GLU A 412 CG CD OE1 OE2
REMARK 470 LEU A 413 CG CD1 CD2
REMARK 470 PHE A 414 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ARG A 415 CG CD NE CZ NH1 NH2
REMARK 470 ASP A 417 CG OD1 OD2
REMARK 470 ILE A 418 CG1 CG2 CD1
REMARK 470 GLN A 419 CG CD OE1 NE2
REMARK 470 GLU A 426 CG CD OE1 OE2
REMARK 470 ASP A 436 CG OD1 OD2
REMARK 470 GLU A 439 CG CD OE1 OE2
REMARK 470 SER A 450 OG
REMARK 470 MET A 458 CG SD CE
REMARK 470 GLN A 462 CG CD OE1 NE2
REMARK 470 SER A 469 OG
REMARK 470 ASN A 470 CG OD1 ND2
REMARK 470 SER A 471 OG
REMARK 470 ASP A 478 CG OD1 OD2
REMARK 470 GLN A 479 CG CD OE1 NE2
REMARK 470 ASP A 561 CG OD1 OD2
REMARK 470 GLU A 580 CG CD OE1 OE2
REMARK 470 SER A 583 OG
REMARK 470 MET A 599 CG SD CE
REMARK 470 GLU A 603 CG CD OE1 OE2
REMARK 470 ASP A 605 CG OD1 OD2
REMARK 470 GLU A 607 CG CD OE1 OE2
REMARK 470 ARG A 611 CG CD NE CZ NH1 NH2
REMARK 470 GLU A 629 CG CD OE1 OE2
REMARK 470 SER A 634 OG
REMARK 470 LEU A 648 CG CD1 CD2
REMARK 470 ASP A 651 CG OD1 OD2
REMARK 470 ASP A 662 CG OD1 OD2
REMARK 470 ASP A 683 CG OD1 OD2
REMARK 470 MET A 684 CG SD CE
REMARK 470 SER A 686 OG
REMARK 470 LEU A 695 CG CD1 CD2
REMARK 470 PHE A 698 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 THR A 705 OG1 CG2
REMARK 470 ARG A 706 CG CD NE CZ NH1 NH2
REMARK 470 LEU A 707 CG CD1 CD2
REMARK 470 ILE A 708 CG1 CG2 CD1
REMARK 470 THR A 709 OG1 CG2
REMARK 470 ARG A 766 CG CD NE CZ NH1 NH2
REMARK 470 ARG A 767 CG CD NE CZ NH1 NH2
REMARK 470 CYS A 768 SG
REMARK 470 ARG A 770 CG CD NE CZ NH1 NH2
REMARK 470 PHE A 773 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 GLN A 806 CG CD OE1 NE2
REMARK 470 CYS A 826 SG
REMARK 470 GLU A 827 CG CD OE1 OE2
REMARK 470 GLU A 828 CG CD OE1 OE2
REMARK 470 SER A 842 OG
REMARK 470 HIS A 849 CG ND1 CD2 CE1 NE2
REMARK 470 SER A 851 OG
REMARK 470 ASP A 868 CG OD1 OD2
REMARK 470 LEU A 883 CG CD1 CD2
REMARK 470 ASP A 956 CG OD1 OD2
REMARK 470 SER A 957 OG
REMARK 470 GLU A 989 CG CD OE1 OE2
REMARK 470 ASN A 992 CG OD1 ND2
REMARK 470 CYS A 993 SG
REMARK 470 SER A 995 OG
REMARK 470 GLU A 996 CG CD OE1 OE2
REMARK 470 ARG A1072 CG CD NE CZ NH1 NH2
REMARK 470 LEU A1075 CG CD1 CD2
REMARK 470 PHE A1079 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ILE A1080 CG1 CG2 CD1
REMARK 470 VAL A1081 CG1 CG2
REMARK 470 ILE A1082 CG1 CG2 CD1
REMARK 470 SER A1083 OG
REMARK 470 HIS A1084 CG ND1 CD2 CE1 NE2
REMARK 470 LEU A1085 CG CD1 CD2
REMARK 470 ARG A1086 CG CD NE CZ NH1 NH2
REMARK 470 LEU A1087 CG CD1 CD2
REMARK 470 LEU A1088 CG CD1 CD2
REMARK 470 LEU A1089 CG CD1 CD2
REMARK 470 ARG A1090 CG CD NE CZ NH1 NH2
REMARK 470 GLN A1091 O CG CD OE1 NE2
REMARK 470 GLU A1107 CG CD OE1 OE2
REMARK 470 HIS A1108 CG ND1 CD2 CE1 NE2
REMARK 470 PHE A1109 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ARG A1110 CG CD NE CZ NH1 NH2
REMARK 470 GLU A1116 CG CD OE1 OE2
REMARK 470 GLU A1130 CG CD OE1 OE2
REMARK 470 GLU A1142 CG CD OE1 OE2
REMARK 470 ASP A1156 CG OD1 OD2
REMARK 470 GLN A1170 CG CD OE1 NE2
REMARK 470 ARG A1171 CG CD NE CZ NH1 NH2
REMARK 470 LYS A1173 CG CD CE NZ
REMARK 470 VAL A1174 CG1 CG2
REMARK 470 LEU A1175 CG CD1 CD2
REMARK 470 GLU A1176 CG CD OE1 OE2
REMARK 470 ARG A1177 CG CD NE CZ NH1 NH2
REMARK 470 GLU A1178 CG CD OE1 OE2
REMARK 470 VAL A1179 CG1 CG2
REMARK 470 GLN A1180 CG CD OE1 NE2
REMARK 470 GLN A1181 CG CD OE1 NE2
REMARK 470 CYS A1182 SG
REMARK 470 SER A1183 OG
REMARK 470 ARG A1184 CG CD NE CZ NH1 NH2
REMARK 470 VAL A1185 CG1 CG2
REMARK 470 LEU A1186 CG CD1 CD2
REMARK 470 TRP A1188 CG CD1 CD2 NE1 CE2 CE3 CZ2
REMARK 470 TRP A1188 CZ3 CH2
REMARK 470 VAL A1189 CG1 CG2
REMARK 470 GLU A1191 CG CD OE1 OE2
REMARK 470 LEU A1193 O CG CD1 CD2
REMARK 470 GLU B 7 CG CD OE1 OE2
REMARK 470 LYS B 13 CG CD CE NZ
REMARK 470 CYS B 20 O SG
REMARK 470 HIS B 66 CG ND1 CD2 CE1 NE2
REMARK 470 THR B 68 OG1 CG2
REMARK 470 GLU B 69 CG CD OE1 OE2
REMARK 470 GLU B 77 CG CD OE1 OE2
REMARK 470 ARG B 85 CG CD NE CZ NH1 NH2
REMARK 470 LYS B 86 CG CD CE NZ
REMARK 470 ARG B 96 CG CD NE CZ NH1 NH2
REMARK 470 ASP B 98 CG OD1 OD2
REMARK 470 ARG B 108 CG CD NE CZ NH1 NH2
REMARK 470 ARG B 113 CG CD NE CZ NH1 NH2
REMARK 470 SER B 125 OG
REMARK 470 ASP B 172 CG OD1 OD2
REMARK 470 MET B 175 CG SD CE
REMARK 470 LYS B 182 CG CD CE NZ
REMARK 470 ASP B 198 CG OD1 OD2
REMARK 470 ASN B 202 CG OD1 ND2
REMARK 470 LYS B 204 CG CD CE NZ
REMARK 470 SER B 206 OG
REMARK 470 ARG B 210 CG CD NE CZ NH1 NH2
REMARK 470 ASP B 237 CG OD1 OD2
REMARK 470 CYS B 242 SG
REMARK 470 LEU B 243 CG CD1 CD2
REMARK 470 THR B 267 OG1 CG2
REMARK 470 ASP B 281 CG OD1 OD2
REMARK 470 GLU B 282 CG CD OE1 OE2
REMARK 470 LYS B 283 CG CD CE NZ
REMARK 470 GLU B 289 CG CD OE1 OE2
REMARK 470 THR B 292 OG1 CG2
REMARK 470 GLN B 295 CG CD OE1 NE2
REMARK 470 CYS B 298 SG
REMARK 470 GLU B 316 CG CD OE1 OE2
REMARK 470 ASP B 317 CG OD1 OD2
REMARK 470 THR B 318 O OG1 CG2
REMARK 470 ARG B 327 CG CD NE CZ NH1 NH2
REMARK 470 ARG B 334 CG CD NE CZ NH1 NH2
REMARK 470 ILE B 335 CG1 CG2 CD1
REMARK 470 ARG B 336 CG CD NE CZ NH1 NH2
REMARK 470 ARG B 337 CG CD NE CZ NH1 NH2
REMARK 470 PHE B 338 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 PHE B 339 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LYS B 341 CG CD CE NZ
REMARK 470 LEU B 344 CG CD1 CD2
REMARK 470 GLU B 345 CG CD OE1 OE2
REMARK 470 GLN B 348 CG CD OE1 NE2
REMARK 470 GLN B 350 CG CD OE1 NE2
REMARK 470 GLU B 352 CG CD OE1 OE2
REMARK 470 LYS B 358 CG CD CE NZ
REMARK 470 GLU B 359 CG CD OE1 OE2
REMARK 470 GLU B 367 CG CD OE1 OE2
REMARK 470 ASP B 368 CG OD1 OD2
REMARK 470 SER B 370 OG
REMARK 470 GLU B 371 CG CD OE1 OE2
REMARK 470 GLU B 372 CG CD OE1 OE2
REMARK 470 CYS B 385 SG
REMARK 470 SER B 387 O OG
REMARK 470 TYR B 393 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 GLU B 412 CG CD OE1 OE2
REMARK 470 LEU B 413 CG CD1 CD2
REMARK 470 PHE B 414 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ARG B 415 CG CD NE CZ NH1 NH2
REMARK 470 ASP B 417 CG OD1 OD2
REMARK 470 ILE B 418 CG1 CG2 CD1
REMARK 470 GLN B 419 CG CD OE1 NE2
REMARK 470 GLU B 426 CG CD OE1 OE2
REMARK 470 ASP B 436 CG OD1 OD2
REMARK 470 GLU B 439 CG CD OE1 OE2
REMARK 470 SER B 450 OG
REMARK 470 MET B 458 CG SD CE
REMARK 470 GLN B 462 CG CD OE1 NE2
REMARK 470 SER B 469 OG
REMARK 470 ASN B 470 CG OD1 ND2
REMARK 470 SER B 471 OG
REMARK 470 ASP B 478 CG OD1 OD2
REMARK 470 GLN B 479 CG CD OE1 NE2
REMARK 470 ASP B 561 CG OD1 OD2
REMARK 470 GLU B 580 CG CD OE1 OE2
REMARK 470 SER B 583 OG
REMARK 470 MET B 599 CG SD CE
REMARK 470 GLU B 603 CG CD OE1 OE2
REMARK 470 ASP B 605 CG OD1 OD2
REMARK 470 GLU B 607 CG CD OE1 OE2
REMARK 470 ARG B 611 CG CD NE CZ NH1 NH2
REMARK 470 GLU B 629 CG CD OE1 OE2
REMARK 470 SER B 634 OG
REMARK 470 LEU B 648 CG CD1 CD2
REMARK 470 ASP B 651 CG OD1 OD2
REMARK 470 ASP B 662 CG OD1 OD2
REMARK 470 ASP B 683 CG OD1 OD2
REMARK 470 MET B 684 CG SD CE
REMARK 470 SER B 686 OG
REMARK 470 LEU B 695 CG CD1 CD2
REMARK 470 PHE B 698 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 THR B 705 OG1 CG2
REMARK 470 ARG B 706 CG CD NE CZ NH1 NH2
REMARK 470 LEU B 707 CG CD1 CD2
REMARK 470 ILE B 708 CG1 CG2 CD1
REMARK 470 THR B 709 OG1 CG2
REMARK 470 ARG B 766 CG CD NE CZ NH1 NH2
REMARK 470 ARG B 767 CG CD NE CZ NH1 NH2
REMARK 470 CYS B 768 SG
REMARK 470 ARG B 770 CG CD NE CZ NH1 NH2
REMARK 470 PHE B 773 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 GLN B 806 CG CD OE1 NE2
REMARK 470 CYS B 826 SG
REMARK 470 GLU B 827 CG CD OE1 OE2
REMARK 470 GLU B 828 CG CD OE1 OE2
REMARK 470 SER B 842 OG
REMARK 470 HIS B 849 CG ND1 CD2 CE1 NE2
REMARK 470 SER B 851 OG
REMARK 470 ASP B 868 CG OD1 OD2
REMARK 470 LEU B 883 CG CD1 CD2
REMARK 470 ASP B 956 CG OD1 OD2
REMARK 470 SER B 957 OG
REMARK 470 GLU B 989 CG CD OE1 OE2
REMARK 470 ASN B 992 CG OD1 ND2
REMARK 470 CYS B 993 SG
REMARK 470 SER B 995 OG
REMARK 470 GLU B 996 CG CD OE1 OE2
REMARK 470 ARG B1072 CG CD NE CZ NH1 NH2
REMARK 470 LEU B1075 CG CD1 CD2
REMARK 470 PHE B1079 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ILE B1080 CG1 CG2 CD1
REMARK 470 VAL B1081 CG1 CG2
REMARK 470 ILE B1082 CG1 CG2 CD1
REMARK 470 SER B1083 OG
REMARK 470 HIS B1084 CG ND1 CD2 CE1 NE2
REMARK 470 LEU B1085 CG CD1 CD2
REMARK 470 ARG B1086 CG CD NE CZ NH1 NH2
REMARK 470 LEU B1087 CG CD1 CD2
REMARK 470 LEU B1088 CG CD1 CD2
REMARK 470 LEU B1089 CG CD1 CD2
REMARK 470 ARG B1090 CG CD NE CZ NH1 NH2
REMARK 470 GLN B1091 O CG CD OE1 NE2
REMARK 470 GLU B1107 CG CD OE1 OE2
REMARK 470 HIS B1108 CG ND1 CD2 CE1 NE2
REMARK 470 PHE B1109 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ARG B1110 CG CD NE CZ NH1 NH2
REMARK 470 GLU B1116 CG CD OE1 OE2
REMARK 470 GLU B1130 CG CD OE1 OE2
REMARK 470 GLU B1142 CG CD OE1 OE2
REMARK 470 ASP B1156 CG OD1 OD2
REMARK 470 GLN B1170 CG CD OE1 NE2
REMARK 470 ARG B1171 CG CD NE CZ NH1 NH2
REMARK 470 LYS B1173 CG CD CE NZ
REMARK 470 VAL B1174 CG1 CG2
REMARK 470 LEU B1175 CG CD1 CD2
REMARK 470 GLU B1176 CG CD OE1 OE2
REMARK 470 ARG B1177 CG CD NE CZ NH1 NH2
REMARK 470 GLU B1178 CG CD OE1 OE2
REMARK 470 VAL B1179 CG1 CG2
REMARK 470 GLN B1180 CG CD OE1 NE2
REMARK 470 GLN B1181 CG CD OE1 NE2
REMARK 470 CYS B1182 SG
REMARK 470 SER B1183 OG
REMARK 470 ARG B1184 CG CD NE CZ NH1 NH2
REMARK 470 VAL B1185 CG1 CG2
REMARK 470 LEU B1186 CG CD1 CD2
REMARK 470 TRP B1188 CG CD1 CD2 NE1 CE2 CE3 CZ2
REMARK 470 TRP B1188 CZ3 CH2
REMARK 470 VAL B1189 CG1 CG2
REMARK 470 GLU B1191 CG CD OE1 OE2
REMARK 470 LEU B1193 O CG CD1 CD2
REMARK 470 GLU C 7 CG CD OE1 OE2
REMARK 470 LYS C 13 CG CD CE NZ
REMARK 470 CYS C 20 O SG
REMARK 470 HIS C 66 CG ND1 CD2 CE1 NE2
REMARK 470 THR C 68 OG1 CG2
REMARK 470 GLU C 69 CG CD OE1 OE2
REMARK 470 GLU C 77 CG CD OE1 OE2
REMARK 470 ARG C 85 CG CD NE CZ NH1 NH2
REMARK 470 LYS C 86 CG CD CE NZ
REMARK 470 ARG C 96 CG CD NE CZ NH1 NH2
REMARK 470 ASP C 98 CG OD1 OD2
REMARK 470 ARG C 108 CG CD NE CZ NH1 NH2
REMARK 470 ARG C 113 CG CD NE CZ NH1 NH2
REMARK 470 SER C 125 OG
REMARK 470 ASP C 172 CG OD1 OD2
REMARK 470 MET C 175 CG SD CE
REMARK 470 LYS C 182 CG CD CE NZ
REMARK 470 ASP C 198 CG OD1 OD2
REMARK 470 ASN C 202 CG OD1 ND2
REMARK 470 LYS C 204 CG CD CE NZ
REMARK 470 SER C 206 OG
REMARK 470 ARG C 210 CG CD NE CZ NH1 NH2
REMARK 470 ASP C 237 CG OD1 OD2
REMARK 470 CYS C 242 SG
REMARK 470 LEU C 243 CG CD1 CD2
REMARK 470 THR C 267 OG1 CG2
REMARK 470 ASP C 281 CG OD1 OD2
REMARK 470 GLU C 282 CG CD OE1 OE2
REMARK 470 LYS C 283 CG CD CE NZ
REMARK 470 GLU C 289 CG CD OE1 OE2
REMARK 470 THR C 292 OG1 CG2
REMARK 470 GLN C 295 CG CD OE1 NE2
REMARK 470 CYS C 298 SG
REMARK 470 GLU C 316 CG CD OE1 OE2
REMARK 470 ASP C 317 CG OD1 OD2
REMARK 470 THR C 318 O OG1 CG2
REMARK 470 ARG C 327 CG CD NE CZ NH1 NH2
REMARK 470 ARG C 334 CG CD NE CZ NH1 NH2
REMARK 470 ILE C 335 CG1 CG2 CD1
REMARK 470 ARG C 336 CG CD NE CZ NH1 NH2
REMARK 470 ARG C 337 CG CD NE CZ NH1 NH2
REMARK 470 PHE C 338 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 PHE C 339 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LYS C 341 CG CD CE NZ
REMARK 470 LEU C 344 CG CD1 CD2
REMARK 470 GLU C 345 CG CD OE1 OE2
REMARK 470 GLN C 348 CG CD OE1 NE2
REMARK 470 GLN C 350 CG CD OE1 NE2
REMARK 470 GLU C 352 CG CD OE1 OE2
REMARK 470 LYS C 358 CG CD CE NZ
REMARK 470 GLU C 359 CG CD OE1 OE2
REMARK 470 GLU C 367 CG CD OE1 OE2
REMARK 470 ASP C 368 CG OD1 OD2
REMARK 470 SER C 370 OG
REMARK 470 GLU C 371 CG CD OE1 OE2
REMARK 470 GLU C 372 CG CD OE1 OE2
REMARK 470 CYS C 385 SG
REMARK 470 SER C 387 O OG
REMARK 470 TYR C 393 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 GLU C 412 CG CD OE1 OE2
REMARK 470 LEU C 413 CG CD1 CD2
REMARK 470 PHE C 414 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ARG C 415 CG CD NE CZ NH1 NH2
REMARK 470 ASP C 417 CG OD1 OD2
REMARK 470 ILE C 418 CG1 CG2 CD1
REMARK 470 GLN C 419 CG CD OE1 NE2
REMARK 470 GLU C 426 CG CD OE1 OE2
REMARK 470 ASP C 436 CG OD1 OD2
REMARK 470 GLU C 439 CG CD OE1 OE2
REMARK 470 SER C 450 OG
REMARK 470 MET C 458 CG SD CE
REMARK 470 GLN C 462 CG CD OE1 NE2
REMARK 470 SER C 469 OG
REMARK 470 ASN C 470 CG OD1 ND2
REMARK 470 SER C 471 OG
REMARK 470 ASP C 478 CG OD1 OD2
REMARK 470 GLN C 479 CG CD OE1 NE2
REMARK 470 ASP C 561 CG OD1 OD2
REMARK 470 GLU C 580 CG CD OE1 OE2
REMARK 470 SER C 583 OG
REMARK 470 MET C 599 CG SD CE
REMARK 470 GLU C 603 CG CD OE1 OE2
REMARK 470 ASP C 605 CG OD1 OD2
REMARK 470 GLU C 607 CG CD OE1 OE2
REMARK 470 ARG C 611 CG CD NE CZ NH1 NH2
REMARK 470 GLU C 629 CG CD OE1 OE2
REMARK 470 SER C 634 OG
REMARK 470 LEU C 648 CG CD1 CD2
REMARK 470 ASP C 651 CG OD1 OD2
REMARK 470 ASP C 662 CG OD1 OD2
REMARK 470 ASP C 683 CG OD1 OD2
REMARK 470 MET C 684 CG SD CE
REMARK 470 SER C 686 OG
REMARK 470 LEU C 695 CG CD1 CD2
REMARK 470 PHE C 698 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 THR C 705 OG1 CG2
REMARK 470 ARG C 706 CG CD NE CZ NH1 NH2
REMARK 470 LEU C 707 CG CD1 CD2
REMARK 470 ILE C 708 CG1 CG2 CD1
REMARK 470 THR C 709 OG1 CG2
REMARK 470 ARG C 766 CG CD NE CZ NH1 NH2
REMARK 470 ARG C 767 CG CD NE CZ NH1 NH2
REMARK 470 CYS C 768 SG
REMARK 470 ARG C 770 CG CD NE CZ NH1 NH2
REMARK 470 PHE C 773 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 GLN C 806 CG CD OE1 NE2
REMARK 470 CYS C 826 SG
REMARK 470 GLU C 827 CG CD OE1 OE2
REMARK 470 GLU C 828 CG CD OE1 OE2
REMARK 470 SER C 842 OG
REMARK 470 HIS C 849 CG ND1 CD2 CE1 NE2
REMARK 470 SER C 851 OG
REMARK 470 ASP C 868 CG OD1 OD2
REMARK 470 LEU C 883 CG CD1 CD2
REMARK 470 ASP C 956 CG OD1 OD2
REMARK 470 SER C 957 OG
REMARK 470 GLU C 989 CG CD OE1 OE2
REMARK 470 ASN C 992 CG OD1 ND2
REMARK 470 CYS C 993 SG
REMARK 470 SER C 995 OG
REMARK 470 GLU C 996 CG CD OE1 OE2
REMARK 470 ARG C1072 CG CD NE CZ NH1 NH2
REMARK 470 LEU C1075 CG CD1 CD2
REMARK 470 PHE C1079 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ILE C1080 CG1 CG2 CD1
REMARK 470 VAL C1081 CG1 CG2
REMARK 470 ILE C1082 CG1 CG2 CD1
REMARK 470 SER C1083 OG
REMARK 470 HIS C1084 CG ND1 CD2 CE1 NE2
REMARK 470 LEU C1085 CG CD1 CD2
REMARK 470 ARG C1086 CG CD NE CZ NH1 NH2
REMARK 470 LEU C1087 CG CD1 CD2
REMARK 470 LEU C1088 CG CD1 CD2
REMARK 470 LEU C1089 CG CD1 CD2
REMARK 470 ARG C1090 CG CD NE CZ NH1 NH2
REMARK 470 GLN C1091 O CG CD OE1 NE2
REMARK 470 GLU C1107 CG CD OE1 OE2
REMARK 470 HIS C1108 CG ND1 CD2 CE1 NE2
REMARK 470 PHE C1109 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ARG C1110 CG CD NE CZ NH1 NH2
REMARK 470 GLU C1116 CG CD OE1 OE2
REMARK 470 GLU C1130 CG CD OE1 OE2
REMARK 470 GLU C1142 CG CD OE1 OE2
REMARK 470 ASP C1156 CG OD1 OD2
REMARK 470 GLN C1170 CG CD OE1 NE2
REMARK 470 ARG C1171 CG CD NE CZ NH1 NH2
REMARK 470 LYS C1173 CG CD CE NZ
REMARK 470 VAL C1174 CG1 CG2
REMARK 470 LEU C1175 CG CD1 CD2
REMARK 470 GLU C1176 CG CD OE1 OE2
REMARK 470 ARG C1177 CG CD NE CZ NH1 NH2
REMARK 470 GLU C1178 CG CD OE1 OE2
REMARK 470 VAL C1179 CG1 CG2
REMARK 470 GLN C1180 CG CD OE1 NE2
REMARK 470 GLN C1181 CG CD OE1 NE2
REMARK 470 CYS C1182 SG
REMARK 470 SER C1183 OG
REMARK 470 ARG C1184 CG CD NE CZ NH1 NH2
REMARK 470 VAL C1185 CG1 CG2
REMARK 470 LEU C1186 CG CD1 CD2
REMARK 470 TRP C1188 CG CD1 CD2 NE1 CE2 CE3 CZ2
REMARK 470 TRP C1188 CZ3 CH2
REMARK 470 VAL C1189 CG1 CG2
REMARK 470 GLU C1191 CG CD OE1 OE2
REMARK 470 LEU C1193 O CG CD1 CD2
REMARK 470 GLU D 7 CG CD OE1 OE2
REMARK 470 LYS D 13 CG CD CE NZ
REMARK 470 CYS D 20 O SG
REMARK 470 HIS D 66 CG ND1 CD2 CE1 NE2
REMARK 470 THR D 68 OG1 CG2
REMARK 470 GLU D 69 CG CD OE1 OE2
REMARK 470 GLU D 77 CG CD OE1 OE2
REMARK 470 ARG D 85 CG CD NE CZ NH1 NH2
REMARK 470 LYS D 86 CG CD CE NZ
REMARK 470 ARG D 96 CG CD NE CZ NH1 NH2
REMARK 470 ASP D 98 CG OD1 OD2
REMARK 470 ARG D 108 CG CD NE CZ NH1 NH2
REMARK 470 ARG D 113 CG CD NE CZ NH1 NH2
REMARK 470 SER D 125 OG
REMARK 470 ASP D 172 CG OD1 OD2
REMARK 470 MET D 175 CG SD CE
REMARK 470 LYS D 182 CG CD CE NZ
REMARK 470 ASP D 198 CG OD1 OD2
REMARK 470 ASN D 202 CG OD1 ND2
REMARK 470 LYS D 204 CG CD CE NZ
REMARK 470 SER D 206 OG
REMARK 470 ARG D 210 CG CD NE CZ NH1 NH2
REMARK 470 ASP D 237 CG OD1 OD2
REMARK 470 CYS D 242 SG
REMARK 470 LEU D 243 CG CD1 CD2
REMARK 470 THR D 267 OG1 CG2
REMARK 470 ASP D 281 CG OD1 OD2
REMARK 470 GLU D 282 CG CD OE1 OE2
REMARK 470 LYS D 283 CG CD CE NZ
REMARK 470 GLU D 289 CG CD OE1 OE2
REMARK 470 THR D 292 OG1 CG2
REMARK 470 GLN D 295 CG CD OE1 NE2
REMARK 470 CYS D 298 SG
REMARK 470 GLU D 316 CG CD OE1 OE2
REMARK 470 ASP D 317 CG OD1 OD2
REMARK 470 THR D 318 O OG1 CG2
REMARK 470 ARG D 327 CG CD NE CZ NH1 NH2
REMARK 470 ARG D 334 CG CD NE CZ NH1 NH2
REMARK 470 ILE D 335 CG1 CG2 CD1
REMARK 470 ARG D 336 CG CD NE CZ NH1 NH2
REMARK 470 ARG D 337 CG CD NE CZ NH1 NH2
REMARK 470 PHE D 338 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 PHE D 339 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LYS D 341 CG CD CE NZ
REMARK 470 LEU D 344 CG CD1 CD2
REMARK 470 GLU D 345 CG CD OE1 OE2
REMARK 470 GLN D 348 CG CD OE1 NE2
REMARK 470 GLN D 350 CG CD OE1 NE2
REMARK 470 GLU D 352 CG CD OE1 OE2
REMARK 470 LYS D 358 CG CD CE NZ
REMARK 470 GLU D 359 CG CD OE1 OE2
REMARK 470 GLU D 367 CG CD OE1 OE2
REMARK 470 ASP D 368 CG OD1 OD2
REMARK 470 SER D 370 OG
REMARK 470 GLU D 371 CG CD OE1 OE2
REMARK 470 GLU D 372 CG CD OE1 OE2
REMARK 470 CYS D 385 SG
REMARK 470 SER D 387 O OG
REMARK 470 TYR D 393 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 GLU D 412 CG CD OE1 OE2
REMARK 470 LEU D 413 CG CD1 CD2
REMARK 470 PHE D 414 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ARG D 415 CG CD NE CZ NH1 NH2
REMARK 470 ASP D 417 CG OD1 OD2
REMARK 470 ILE D 418 CG1 CG2 CD1
REMARK 470 GLN D 419 CG CD OE1 NE2
REMARK 470 GLU D 426 CG CD OE1 OE2
REMARK 470 ASP D 436 CG OD1 OD2
REMARK 470 GLU D 439 CG CD OE1 OE2
REMARK 470 SER D 450 OG
REMARK 470 MET D 458 CG SD CE
REMARK 470 GLN D 462 CG CD OE1 NE2
REMARK 470 SER D 469 OG
REMARK 470 ASN D 470 CG OD1 ND2
REMARK 470 SER D 471 OG
REMARK 470 ASP D 478 CG OD1 OD2
REMARK 470 GLN D 479 CG CD OE1 NE2
REMARK 470 ASP D 561 CG OD1 OD2
REMARK 470 GLU D 580 CG CD OE1 OE2
REMARK 470 SER D 583 OG
REMARK 470 MET D 599 CG SD CE
REMARK 470 GLU D 603 CG CD OE1 OE2
REMARK 470 ASP D 605 CG OD1 OD2
REMARK 470 GLU D 607 CG CD OE1 OE2
REMARK 470 ARG D 611 CG CD NE CZ NH1 NH2
REMARK 470 GLU D 629 CG CD OE1 OE2
REMARK 470 SER D 634 OG
REMARK 470 LEU D 648 CG CD1 CD2
REMARK 470 ASP D 651 CG OD1 OD2
REMARK 470 ASP D 662 CG OD1 OD2
REMARK 470 ASP D 683 CG OD1 OD2
REMARK 470 MET D 684 CG SD CE
REMARK 470 SER D 686 OG
REMARK 470 LEU D 695 CG CD1 CD2
REMARK 470 PHE D 698 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 THR D 705 OG1 CG2
REMARK 470 ARG D 706 CG CD NE CZ NH1 NH2
REMARK 470 LEU D 707 CG CD1 CD2
REMARK 470 ILE D 708 CG1 CG2 CD1
REMARK 470 THR D 709 OG1 CG2
REMARK 470 ARG D 766 CG CD NE CZ NH1 NH2
REMARK 470 ARG D 767 CG CD NE CZ NH1 NH2
REMARK 470 CYS D 768 SG
REMARK 470 ARG D 770 CG CD NE CZ NH1 NH2
REMARK 470 PHE D 773 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 GLN D 806 CG CD OE1 NE2
REMARK 470 CYS D 826 SG
REMARK 470 GLU D 827 CG CD OE1 OE2
REMARK 470 GLU D 828 CG CD OE1 OE2
REMARK 470 SER D 842 OG
REMARK 470 HIS D 849 CG ND1 CD2 CE1 NE2
REMARK 470 SER D 851 OG
REMARK 470 ASP D 868 CG OD1 OD2
REMARK 470 LEU D 883 CG CD1 CD2
REMARK 470 ASP D 956 CG OD1 OD2
REMARK 470 SER D 957 OG
REMARK 470 GLU D 989 CG CD OE1 OE2
REMARK 470 ASN D 992 CG OD1 ND2
REMARK 470 CYS D 993 SG
REMARK 470 SER D 995 OG
REMARK 470 GLU D 996 CG CD OE1 OE2
REMARK 470 ARG D1072 CG CD NE CZ NH1 NH2
REMARK 470 LEU D1075 CG CD1 CD2
REMARK 470 PHE D1079 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ILE D1080 CG1 CG2 CD1
REMARK 470 VAL D1081 CG1 CG2
REMARK 470 ILE D1082 CG1 CG2 CD1
REMARK 470 SER D1083 OG
REMARK 470 HIS D1084 CG ND1 CD2 CE1 NE2
REMARK 470 LEU D1085 CG CD1 CD2
REMARK 470 ARG D1086 CG CD NE CZ NH1 NH2
REMARK 470 LEU D1087 CG CD1 CD2
REMARK 470 LEU D1088 CG CD1 CD2
REMARK 470 LEU D1089 CG CD1 CD2
REMARK 470 ARG D1090 CG CD NE CZ NH1 NH2
REMARK 470 GLN D1091 O CG CD OE1 NE2
REMARK 470 GLU D1107 CG CD OE1 OE2
REMARK 470 HIS D1108 CG ND1 CD2 CE1 NE2
REMARK 470 PHE D1109 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ARG D1110 CG CD NE CZ NH1 NH2
REMARK 470 GLU D1116 CG CD OE1 OE2
REMARK 470 GLU D1130 CG CD OE1 OE2
REMARK 470 GLU D1142 CG CD OE1 OE2
REMARK 470 ASP D1156 CG OD1 OD2
REMARK 470 GLN D1170 CG CD OE1 NE2
REMARK 470 ARG D1171 CG CD NE CZ NH1 NH2
REMARK 470 LYS D1173 CG CD CE NZ
REMARK 470 VAL D1174 CG1 CG2
REMARK 470 LEU D1175 CG CD1 CD2
REMARK 470 GLU D1176 CG CD OE1 OE2
REMARK 470 ARG D1177 CG CD NE CZ NH1 NH2
REMARK 470 GLU D1178 CG CD OE1 OE2
REMARK 470 VAL D1179 CG1 CG2
REMARK 470 GLN D1180 CG CD OE1 NE2
REMARK 470 GLN D1181 CG CD OE1 NE2
REMARK 470 CYS D1182 SG
REMARK 470 SER D1183 OG
REMARK 470 ARG D1184 CG CD NE CZ NH1 NH2
REMARK 470 VAL D1185 CG1 CG2
REMARK 470 LEU D1186 CG CD1 CD2
REMARK 470 TRP D1188 CG CD1 CD2 NE1 CE2 CE3 CZ2
REMARK 470 TRP D1188 CZ3 CH2
REMARK 470 VAL D1189 CG1 CG2
REMARK 470 GLU D1191 CG CD OE1 OE2
REMARK 470 LEU D1193 O CG CD1 CD2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 LEU A 158 -167.27 -79.48
REMARK 500 THR A 181 70.19 57.22
REMARK 500 TYR A 227 70.10 -112.59
REMARK 500 ASN A 228 -2.10 -145.56
REMARK 500 THR A 239 -178.23 -176.47
REMARK 500 ASP A 279 131.70 -36.61
REMARK 500 LYS A 341 -36.84 -134.64
REMARK 500 GLN A 348 -62.17 -94.48
REMARK 500 GLU A 371 19.97 59.81
REMARK 500 SER A 634 70.77 60.21
REMARK 500 MET A 684 66.49 60.61
REMARK 500 ASP A 804 -154.49 -81.23
REMARK 500 ARG A 953 76.34 51.30
REMARK 500 ARG A 955 47.18 -90.73
REMARK 500 GLN A1007 -9.55 71.02
REMARK 500 ALA A1008 48.34 -96.98
REMARK 500 ALA A1192 13.05 -142.43
REMARK 500 LEU B 158 -167.22 -79.47
REMARK 500 THR B 181 70.17 57.21
REMARK 500 TYR B 227 70.15 -112.60
REMARK 500 ASN B 228 -2.12 -145.59
REMARK 500 THR B 239 -178.22 -176.52
REMARK 500 ASP B 279 131.65 -36.58
REMARK 500 LYS B 341 -36.83 -134.57
REMARK 500 GLN B 348 -62.23 -94.50
REMARK 500 GLU B 371 19.97 59.88
REMARK 500 SER B 634 70.78 60.25
REMARK 500 MET B 684 66.46 60.62
REMARK 500 ASP B 804 -154.50 -81.25
REMARK 500 ARG B 953 76.39 51.23
REMARK 500 ARG B 955 47.17 -90.75
REMARK 500 GLN B1007 -9.54 71.02
REMARK 500 ALA B1008 48.30 -96.92
REMARK 500 ALA B1192 13.01 -142.46
REMARK 500 LEU C 158 -167.23 -79.46
REMARK 500 THR C 181 70.20 57.19
REMARK 500 TYR C 227 70.05 -112.59
REMARK 500 ASN C 228 -2.06 -145.56
REMARK 500 THR C 239 -178.21 -176.42
REMARK 500 ASP C 279 131.70 -36.60
REMARK 500 LYS C 341 -36.88 -134.62
REMARK 500 GLN C 348 -62.20 -94.51
REMARK 500 GLU C 371 19.95 59.80
REMARK 500 SER C 634 70.71 60.27
REMARK 500 MET C 684 66.51 60.60
REMARK 500 ASP C 804 -154.48 -81.27
REMARK 500 ARG C 953 76.29 51.28
REMARK 500 ARG C 955 47.19 -90.78
REMARK 500 GLN C1007 -9.65 71.06
REMARK 500 ALA C1008 48.32 -96.88
REMARK 500
REMARK 500 THIS ENTRY HAS 68 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DVT A 2001
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DVT A 2002
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DVT B 2001
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DVT B 2002
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DVT C 2001
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DVT C 2002
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DVT D 2001
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DVT D 2002
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-8871 RELATED DB: EMDB
REMARK 900 CRYO-EM STRUCTURE OF A HUMAN TRPM4 CHANNEL IN COMPLEX WITH CALCIUM
REMARK 900 AND DECAVANADATE
REMARK 900 RELATED ID: EMD-8873 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-8875 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-8876 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-8877 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-8878 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-8879 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-8872 RELATED DB: EMDB
DBREF 5WP6 A 1 1214 UNP Q8TD43 TRPM4_HUMAN 1 1214
DBREF 5WP6 B 1 1214 UNP Q8TD43 TRPM4_HUMAN 1 1214
DBREF 5WP6 C 1 1214 UNP Q8TD43 TRPM4_HUMAN 1 1214
DBREF 5WP6 D 1 1214 UNP Q8TD43 TRPM4_HUMAN 1 1214
SEQRES 1 A 1214 MET VAL VAL PRO GLU LYS GLU GLN SER TRP ILE PRO LYS
SEQRES 2 A 1214 ILE PHE LYS LYS LYS THR CYS THR THR PHE ILE VAL ASP
SEQRES 3 A 1214 SER THR ASP PRO GLY GLY THR LEU CYS GLN CYS GLY ARG
SEQRES 4 A 1214 PRO ARG THR ALA HIS PRO ALA VAL ALA MET GLU ASP ALA
SEQRES 5 A 1214 PHE GLY ALA ALA VAL VAL THR VAL TRP ASP SER ASP ALA
SEQRES 6 A 1214 HIS THR THR GLU LYS PRO THR ASP ALA TYR GLY GLU LEU
SEQRES 7 A 1214 ASP PHE THR GLY ALA GLY ARG LYS HIS SER ASN PHE LEU
SEQRES 8 A 1214 ARG LEU SER ASP ARG THR ASP PRO ALA ALA VAL TYR SER
SEQRES 9 A 1214 LEU VAL THR ARG THR TRP GLY PHE ARG ALA PRO ASN LEU
SEQRES 10 A 1214 VAL VAL SER VAL LEU GLY GLY SER GLY GLY PRO VAL LEU
SEQRES 11 A 1214 GLN THR TRP LEU GLN ASP LEU LEU ARG ARG GLY LEU VAL
SEQRES 12 A 1214 ARG ALA ALA GLN SER THR GLY ALA TRP ILE VAL THR GLY
SEQRES 13 A 1214 GLY LEU HIS THR GLY ILE GLY ARG HIS VAL GLY VAL ALA
SEQRES 14 A 1214 VAL ARG ASP HIS GLN MET ALA SER THR GLY GLY THR LYS
SEQRES 15 A 1214 VAL VAL ALA MET GLY VAL ALA PRO TRP GLY VAL VAL ARG
SEQRES 16 A 1214 ASN ARG ASP THR LEU ILE ASN PRO LYS GLY SER PHE PRO
SEQRES 17 A 1214 ALA ARG TYR ARG TRP ARG GLY ASP PRO GLU ASP GLY VAL
SEQRES 18 A 1214 GLN PHE PRO LEU ASP TYR ASN TYR SER ALA PHE PHE LEU
SEQRES 19 A 1214 VAL ASP ASP GLY THR HIS GLY CYS LEU GLY GLY GLU ASN
SEQRES 20 A 1214 ARG PHE ARG LEU ARG LEU GLU SER TYR ILE SER GLN GLN
SEQRES 21 A 1214 LYS THR GLY VAL GLY GLY THR GLY ILE ASP ILE PRO VAL
SEQRES 22 A 1214 LEU LEU LEU LEU ILE ASP GLY ASP GLU LYS MET LEU THR
SEQRES 23 A 1214 ARG ILE GLU ASN ALA THR GLN ALA GLN LEU PRO CYS LEU
SEQRES 24 A 1214 LEU VAL ALA GLY SER GLY GLY ALA ALA ASP CYS LEU ALA
SEQRES 25 A 1214 GLU THR LEU GLU ASP THR LEU ALA PRO GLY SER GLY GLY
SEQRES 26 A 1214 ALA ARG GLN GLY GLU ALA ARG ASP ARG ILE ARG ARG PHE
SEQRES 27 A 1214 PHE PRO LYS GLY ASP LEU GLU VAL LEU GLN ALA GLN VAL
SEQRES 28 A 1214 GLU ARG ILE MET THR ARG LYS GLU LEU LEU THR VAL TYR
SEQRES 29 A 1214 SER SER GLU ASP GLY SER GLU GLU PHE GLU THR ILE VAL
SEQRES 30 A 1214 LEU LYS ALA LEU VAL LYS ALA CYS GLY SER SER GLU ALA
SEQRES 31 A 1214 SER ALA TYR LEU ASP GLU LEU ARG LEU ALA VAL ALA TRP
SEQRES 32 A 1214 ASN ARG VAL ASP ILE ALA GLN SER GLU LEU PHE ARG GLY
SEQRES 33 A 1214 ASP ILE GLN TRP ARG SER PHE HIS LEU GLU ALA SER LEU
SEQRES 34 A 1214 MET ASP ALA LEU LEU ASN ASP ARG PRO GLU PHE VAL ARG
SEQRES 35 A 1214 LEU LEU ILE SER HIS GLY LEU SER LEU GLY HIS PHE LEU
SEQRES 36 A 1214 THR PRO MET ARG LEU ALA GLN LEU TYR SER ALA ALA PRO
SEQRES 37 A 1214 SER ASN SER LEU ILE ARG ASN LEU LEU ASP GLN ALA SER
SEQRES 38 A 1214 HIS SER ALA GLY THR LYS ALA PRO ALA LEU LYS GLY GLY
SEQRES 39 A 1214 ALA ALA GLU LEU ARG PRO PRO ASP VAL GLY HIS VAL LEU
SEQRES 40 A 1214 ARG MET LEU LEU GLY LYS MET CYS ALA PRO ARG TYR PRO
SEQRES 41 A 1214 SER GLY GLY ALA TRP ASP PRO HIS PRO GLY GLN GLY PHE
SEQRES 42 A 1214 GLY GLU SER MET TYR LEU LEU SER ASP LYS ALA THR SER
SEQRES 43 A 1214 PRO LEU SER LEU ASP ALA GLY LEU GLY GLN ALA PRO TRP
SEQRES 44 A 1214 SER ASP LEU LEU LEU TRP ALA LEU LEU LEU ASN ARG ALA
SEQRES 45 A 1214 GLN MET ALA MET TYR PHE TRP GLU MET GLY SER ASN ALA
SEQRES 46 A 1214 VAL SER SER ALA LEU GLY ALA CYS LEU LEU LEU ARG VAL
SEQRES 47 A 1214 MET ALA ARG LEU GLU PRO ASP ALA GLU GLU ALA ALA ARG
SEQRES 48 A 1214 ARG LYS ASP LEU ALA PHE LYS PHE GLU GLY MET GLY VAL
SEQRES 49 A 1214 ASP LEU PHE GLY GLU CYS TYR ARG SER SER GLU VAL ARG
SEQRES 50 A 1214 ALA ALA ARG LEU LEU LEU ARG ARG CYS PRO LEU TRP GLY
SEQRES 51 A 1214 ASP ALA THR CYS LEU GLN LEU ALA MET GLN ALA ASP ALA
SEQRES 52 A 1214 ARG ALA PHE PHE ALA GLN ASP GLY VAL GLN SER LEU LEU
SEQRES 53 A 1214 THR GLN LYS TRP TRP GLY ASP MET ALA SER THR THR PRO
SEQRES 54 A 1214 ILE TRP ALA LEU VAL LEU ALA PHE PHE CYS PRO PRO LEU
SEQRES 55 A 1214 ILE TYR THR ARG LEU ILE THR PHE ARG LYS SER GLU GLU
SEQRES 56 A 1214 GLU PRO THR ARG GLU GLU LEU GLU PHE ASP MET ASP SER
SEQRES 57 A 1214 VAL ILE ASN GLY GLU GLY PRO VAL GLY THR ALA ASP PRO
SEQRES 58 A 1214 ALA GLU LYS THR PRO LEU GLY VAL PRO ARG GLN SER GLY
SEQRES 59 A 1214 ARG PRO GLY CYS CYS GLY GLY ARG CYS GLY GLY ARG ARG
SEQRES 60 A 1214 CYS LEU ARG ARG TRP PHE HIS PHE TRP GLY ALA PRO VAL
SEQRES 61 A 1214 THR ILE PHE MET GLY ASN VAL VAL SER TYR LEU LEU PHE
SEQRES 62 A 1214 LEU LEU LEU PHE SER ARG VAL LEU LEU VAL ASP PHE GLN
SEQRES 63 A 1214 PRO ALA PRO PRO GLY SER LEU GLU LEU LEU LEU TYR PHE
SEQRES 64 A 1214 TRP ALA PHE THR LEU LEU CYS GLU GLU LEU ARG GLN GLY
SEQRES 65 A 1214 LEU SER GLY GLY GLY GLY SER LEU ALA SER GLY GLY PRO
SEQRES 66 A 1214 GLY PRO GLY HIS ALA SER LEU SER GLN ARG LEU ARG LEU
SEQRES 67 A 1214 TYR LEU ALA ASP SER TRP ASN GLN CYS ASP LEU VAL ALA
SEQRES 68 A 1214 LEU THR CYS PHE LEU LEU GLY VAL GLY CYS ARG LEU THR
SEQRES 69 A 1214 PRO GLY LEU TYR HIS LEU GLY ARG THR VAL LEU CYS ILE
SEQRES 70 A 1214 ASP PHE MET VAL PHE THR VAL ARG LEU LEU HIS ILE PHE
SEQRES 71 A 1214 THR VAL ASN LYS GLN LEU GLY PRO LYS ILE VAL ILE VAL
SEQRES 72 A 1214 SER LYS MET MET LYS ASP VAL PHE PHE PHE LEU PHE PHE
SEQRES 73 A 1214 LEU GLY VAL TRP LEU VAL ALA TYR GLY VAL ALA THR GLU
SEQRES 74 A 1214 GLY LEU LEU ARG PRO ARG ASP SER ASP PHE PRO SER ILE
SEQRES 75 A 1214 LEU ARG ARG VAL PHE TYR ARG PRO TYR LEU GLN ILE PHE
SEQRES 76 A 1214 GLY GLN ILE PRO GLN GLU ASP MET ASP VAL ALA LEU MET
SEQRES 77 A 1214 GLU HIS SER ASN CYS SER SER GLU PRO GLY PHE TRP ALA
SEQRES 78 A 1214 HIS PRO PRO GLY ALA GLN ALA GLY THR CYS VAL SER GLN
SEQRES 79 A 1214 TYR ALA ASN TRP LEU VAL VAL LEU LEU LEU VAL ILE PHE
SEQRES 80 A 1214 LEU LEU VAL ALA ASN ILE LEU LEU VAL ASN LEU LEU ILE
SEQRES 81 A 1214 ALA MET PHE SER TYR THR PHE GLY LYS VAL GLN GLY ASN
SEQRES 82 A 1214 SER ASP LEU TYR TRP LYS ALA GLN ARG TYR ARG LEU ILE
SEQRES 83 A 1214 ARG GLU PHE HIS SER ARG PRO ALA LEU ALA PRO PRO PHE
SEQRES 84 A 1214 ILE VAL ILE SER HIS LEU ARG LEU LEU LEU ARG GLN LEU
SEQRES 85 A 1214 CYS ARG ARG PRO ARG SER PRO GLN PRO SER SER PRO ALA
SEQRES 86 A 1214 LEU GLU HIS PHE ARG VAL TYR LEU SER LYS GLU ALA GLU
SEQRES 87 A 1214 ARG LYS LEU LEU THR TRP GLU SER VAL HIS LYS GLU ASN
SEQRES 88 A 1214 PHE LEU LEU ALA ARG ALA ARG ASP LYS ARG GLU SER ASP
SEQRES 89 A 1214 SER GLU ARG LEU LYS ARG THR SER GLN LYS VAL ASP LEU
SEQRES 90 A 1214 ALA LEU LYS GLN LEU GLY HIS ILE ARG GLU TYR GLU GLN
SEQRES 91 A 1214 ARG LEU LYS VAL LEU GLU ARG GLU VAL GLN GLN CYS SER
SEQRES 92 A 1214 ARG VAL LEU GLY TRP VAL ALA GLU ALA LEU SER ARG SER
SEQRES 93 A 1214 ALA LEU LEU PRO PRO GLY GLY PRO PRO PRO PRO ASP LEU
SEQRES 94 A 1214 PRO GLY SER LYS ASP
SEQRES 1 B 1214 MET VAL VAL PRO GLU LYS GLU GLN SER TRP ILE PRO LYS
SEQRES 2 B 1214 ILE PHE LYS LYS LYS THR CYS THR THR PHE ILE VAL ASP
SEQRES 3 B 1214 SER THR ASP PRO GLY GLY THR LEU CYS GLN CYS GLY ARG
SEQRES 4 B 1214 PRO ARG THR ALA HIS PRO ALA VAL ALA MET GLU ASP ALA
SEQRES 5 B 1214 PHE GLY ALA ALA VAL VAL THR VAL TRP ASP SER ASP ALA
SEQRES 6 B 1214 HIS THR THR GLU LYS PRO THR ASP ALA TYR GLY GLU LEU
SEQRES 7 B 1214 ASP PHE THR GLY ALA GLY ARG LYS HIS SER ASN PHE LEU
SEQRES 8 B 1214 ARG LEU SER ASP ARG THR ASP PRO ALA ALA VAL TYR SER
SEQRES 9 B 1214 LEU VAL THR ARG THR TRP GLY PHE ARG ALA PRO ASN LEU
SEQRES 10 B 1214 VAL VAL SER VAL LEU GLY GLY SER GLY GLY PRO VAL LEU
SEQRES 11 B 1214 GLN THR TRP LEU GLN ASP LEU LEU ARG ARG GLY LEU VAL
SEQRES 12 B 1214 ARG ALA ALA GLN SER THR GLY ALA TRP ILE VAL THR GLY
SEQRES 13 B 1214 GLY LEU HIS THR GLY ILE GLY ARG HIS VAL GLY VAL ALA
SEQRES 14 B 1214 VAL ARG ASP HIS GLN MET ALA SER THR GLY GLY THR LYS
SEQRES 15 B 1214 VAL VAL ALA MET GLY VAL ALA PRO TRP GLY VAL VAL ARG
SEQRES 16 B 1214 ASN ARG ASP THR LEU ILE ASN PRO LYS GLY SER PHE PRO
SEQRES 17 B 1214 ALA ARG TYR ARG TRP ARG GLY ASP PRO GLU ASP GLY VAL
SEQRES 18 B 1214 GLN PHE PRO LEU ASP TYR ASN TYR SER ALA PHE PHE LEU
SEQRES 19 B 1214 VAL ASP ASP GLY THR HIS GLY CYS LEU GLY GLY GLU ASN
SEQRES 20 B 1214 ARG PHE ARG LEU ARG LEU GLU SER TYR ILE SER GLN GLN
SEQRES 21 B 1214 LYS THR GLY VAL GLY GLY THR GLY ILE ASP ILE PRO VAL
SEQRES 22 B 1214 LEU LEU LEU LEU ILE ASP GLY ASP GLU LYS MET LEU THR
SEQRES 23 B 1214 ARG ILE GLU ASN ALA THR GLN ALA GLN LEU PRO CYS LEU
SEQRES 24 B 1214 LEU VAL ALA GLY SER GLY GLY ALA ALA ASP CYS LEU ALA
SEQRES 25 B 1214 GLU THR LEU GLU ASP THR LEU ALA PRO GLY SER GLY GLY
SEQRES 26 B 1214 ALA ARG GLN GLY GLU ALA ARG ASP ARG ILE ARG ARG PHE
SEQRES 27 B 1214 PHE PRO LYS GLY ASP LEU GLU VAL LEU GLN ALA GLN VAL
SEQRES 28 B 1214 GLU ARG ILE MET THR ARG LYS GLU LEU LEU THR VAL TYR
SEQRES 29 B 1214 SER SER GLU ASP GLY SER GLU GLU PHE GLU THR ILE VAL
SEQRES 30 B 1214 LEU LYS ALA LEU VAL LYS ALA CYS GLY SER SER GLU ALA
SEQRES 31 B 1214 SER ALA TYR LEU ASP GLU LEU ARG LEU ALA VAL ALA TRP
SEQRES 32 B 1214 ASN ARG VAL ASP ILE ALA GLN SER GLU LEU PHE ARG GLY
SEQRES 33 B 1214 ASP ILE GLN TRP ARG SER PHE HIS LEU GLU ALA SER LEU
SEQRES 34 B 1214 MET ASP ALA LEU LEU ASN ASP ARG PRO GLU PHE VAL ARG
SEQRES 35 B 1214 LEU LEU ILE SER HIS GLY LEU SER LEU GLY HIS PHE LEU
SEQRES 36 B 1214 THR PRO MET ARG LEU ALA GLN LEU TYR SER ALA ALA PRO
SEQRES 37 B 1214 SER ASN SER LEU ILE ARG ASN LEU LEU ASP GLN ALA SER
SEQRES 38 B 1214 HIS SER ALA GLY THR LYS ALA PRO ALA LEU LYS GLY GLY
SEQRES 39 B 1214 ALA ALA GLU LEU ARG PRO PRO ASP VAL GLY HIS VAL LEU
SEQRES 40 B 1214 ARG MET LEU LEU GLY LYS MET CYS ALA PRO ARG TYR PRO
SEQRES 41 B 1214 SER GLY GLY ALA TRP ASP PRO HIS PRO GLY GLN GLY PHE
SEQRES 42 B 1214 GLY GLU SER MET TYR LEU LEU SER ASP LYS ALA THR SER
SEQRES 43 B 1214 PRO LEU SER LEU ASP ALA GLY LEU GLY GLN ALA PRO TRP
SEQRES 44 B 1214 SER ASP LEU LEU LEU TRP ALA LEU LEU LEU ASN ARG ALA
SEQRES 45 B 1214 GLN MET ALA MET TYR PHE TRP GLU MET GLY SER ASN ALA
SEQRES 46 B 1214 VAL SER SER ALA LEU GLY ALA CYS LEU LEU LEU ARG VAL
SEQRES 47 B 1214 MET ALA ARG LEU GLU PRO ASP ALA GLU GLU ALA ALA ARG
SEQRES 48 B 1214 ARG LYS ASP LEU ALA PHE LYS PHE GLU GLY MET GLY VAL
SEQRES 49 B 1214 ASP LEU PHE GLY GLU CYS TYR ARG SER SER GLU VAL ARG
SEQRES 50 B 1214 ALA ALA ARG LEU LEU LEU ARG ARG CYS PRO LEU TRP GLY
SEQRES 51 B 1214 ASP ALA THR CYS LEU GLN LEU ALA MET GLN ALA ASP ALA
SEQRES 52 B 1214 ARG ALA PHE PHE ALA GLN ASP GLY VAL GLN SER LEU LEU
SEQRES 53 B 1214 THR GLN LYS TRP TRP GLY ASP MET ALA SER THR THR PRO
SEQRES 54 B 1214 ILE TRP ALA LEU VAL LEU ALA PHE PHE CYS PRO PRO LEU
SEQRES 55 B 1214 ILE TYR THR ARG LEU ILE THR PHE ARG LYS SER GLU GLU
SEQRES 56 B 1214 GLU PRO THR ARG GLU GLU LEU GLU PHE ASP MET ASP SER
SEQRES 57 B 1214 VAL ILE ASN GLY GLU GLY PRO VAL GLY THR ALA ASP PRO
SEQRES 58 B 1214 ALA GLU LYS THR PRO LEU GLY VAL PRO ARG GLN SER GLY
SEQRES 59 B 1214 ARG PRO GLY CYS CYS GLY GLY ARG CYS GLY GLY ARG ARG
SEQRES 60 B 1214 CYS LEU ARG ARG TRP PHE HIS PHE TRP GLY ALA PRO VAL
SEQRES 61 B 1214 THR ILE PHE MET GLY ASN VAL VAL SER TYR LEU LEU PHE
SEQRES 62 B 1214 LEU LEU LEU PHE SER ARG VAL LEU LEU VAL ASP PHE GLN
SEQRES 63 B 1214 PRO ALA PRO PRO GLY SER LEU GLU LEU LEU LEU TYR PHE
SEQRES 64 B 1214 TRP ALA PHE THR LEU LEU CYS GLU GLU LEU ARG GLN GLY
SEQRES 65 B 1214 LEU SER GLY GLY GLY GLY SER LEU ALA SER GLY GLY PRO
SEQRES 66 B 1214 GLY PRO GLY HIS ALA SER LEU SER GLN ARG LEU ARG LEU
SEQRES 67 B 1214 TYR LEU ALA ASP SER TRP ASN GLN CYS ASP LEU VAL ALA
SEQRES 68 B 1214 LEU THR CYS PHE LEU LEU GLY VAL GLY CYS ARG LEU THR
SEQRES 69 B 1214 PRO GLY LEU TYR HIS LEU GLY ARG THR VAL LEU CYS ILE
SEQRES 70 B 1214 ASP PHE MET VAL PHE THR VAL ARG LEU LEU HIS ILE PHE
SEQRES 71 B 1214 THR VAL ASN LYS GLN LEU GLY PRO LYS ILE VAL ILE VAL
SEQRES 72 B 1214 SER LYS MET MET LYS ASP VAL PHE PHE PHE LEU PHE PHE
SEQRES 73 B 1214 LEU GLY VAL TRP LEU VAL ALA TYR GLY VAL ALA THR GLU
SEQRES 74 B 1214 GLY LEU LEU ARG PRO ARG ASP SER ASP PHE PRO SER ILE
SEQRES 75 B 1214 LEU ARG ARG VAL PHE TYR ARG PRO TYR LEU GLN ILE PHE
SEQRES 76 B 1214 GLY GLN ILE PRO GLN GLU ASP MET ASP VAL ALA LEU MET
SEQRES 77 B 1214 GLU HIS SER ASN CYS SER SER GLU PRO GLY PHE TRP ALA
SEQRES 78 B 1214 HIS PRO PRO GLY ALA GLN ALA GLY THR CYS VAL SER GLN
SEQRES 79 B 1214 TYR ALA ASN TRP LEU VAL VAL LEU LEU LEU VAL ILE PHE
SEQRES 80 B 1214 LEU LEU VAL ALA ASN ILE LEU LEU VAL ASN LEU LEU ILE
SEQRES 81 B 1214 ALA MET PHE SER TYR THR PHE GLY LYS VAL GLN GLY ASN
SEQRES 82 B 1214 SER ASP LEU TYR TRP LYS ALA GLN ARG TYR ARG LEU ILE
SEQRES 83 B 1214 ARG GLU PHE HIS SER ARG PRO ALA LEU ALA PRO PRO PHE
SEQRES 84 B 1214 ILE VAL ILE SER HIS LEU ARG LEU LEU LEU ARG GLN LEU
SEQRES 85 B 1214 CYS ARG ARG PRO ARG SER PRO GLN PRO SER SER PRO ALA
SEQRES 86 B 1214 LEU GLU HIS PHE ARG VAL TYR LEU SER LYS GLU ALA GLU
SEQRES 87 B 1214 ARG LYS LEU LEU THR TRP GLU SER VAL HIS LYS GLU ASN
SEQRES 88 B 1214 PHE LEU LEU ALA ARG ALA ARG ASP LYS ARG GLU SER ASP
SEQRES 89 B 1214 SER GLU ARG LEU LYS ARG THR SER GLN LYS VAL ASP LEU
SEQRES 90 B 1214 ALA LEU LYS GLN LEU GLY HIS ILE ARG GLU TYR GLU GLN
SEQRES 91 B 1214 ARG LEU LYS VAL LEU GLU ARG GLU VAL GLN GLN CYS SER
SEQRES 92 B 1214 ARG VAL LEU GLY TRP VAL ALA GLU ALA LEU SER ARG SER
SEQRES 93 B 1214 ALA LEU LEU PRO PRO GLY GLY PRO PRO PRO PRO ASP LEU
SEQRES 94 B 1214 PRO GLY SER LYS ASP
SEQRES 1 C 1214 MET VAL VAL PRO GLU LYS GLU GLN SER TRP ILE PRO LYS
SEQRES 2 C 1214 ILE PHE LYS LYS LYS THR CYS THR THR PHE ILE VAL ASP
SEQRES 3 C 1214 SER THR ASP PRO GLY GLY THR LEU CYS GLN CYS GLY ARG
SEQRES 4 C 1214 PRO ARG THR ALA HIS PRO ALA VAL ALA MET GLU ASP ALA
SEQRES 5 C 1214 PHE GLY ALA ALA VAL VAL THR VAL TRP ASP SER ASP ALA
SEQRES 6 C 1214 HIS THR THR GLU LYS PRO THR ASP ALA TYR GLY GLU LEU
SEQRES 7 C 1214 ASP PHE THR GLY ALA GLY ARG LYS HIS SER ASN PHE LEU
SEQRES 8 C 1214 ARG LEU SER ASP ARG THR ASP PRO ALA ALA VAL TYR SER
SEQRES 9 C 1214 LEU VAL THR ARG THR TRP GLY PHE ARG ALA PRO ASN LEU
SEQRES 10 C 1214 VAL VAL SER VAL LEU GLY GLY SER GLY GLY PRO VAL LEU
SEQRES 11 C 1214 GLN THR TRP LEU GLN ASP LEU LEU ARG ARG GLY LEU VAL
SEQRES 12 C 1214 ARG ALA ALA GLN SER THR GLY ALA TRP ILE VAL THR GLY
SEQRES 13 C 1214 GLY LEU HIS THR GLY ILE GLY ARG HIS VAL GLY VAL ALA
SEQRES 14 C 1214 VAL ARG ASP HIS GLN MET ALA SER THR GLY GLY THR LYS
SEQRES 15 C 1214 VAL VAL ALA MET GLY VAL ALA PRO TRP GLY VAL VAL ARG
SEQRES 16 C 1214 ASN ARG ASP THR LEU ILE ASN PRO LYS GLY SER PHE PRO
SEQRES 17 C 1214 ALA ARG TYR ARG TRP ARG GLY ASP PRO GLU ASP GLY VAL
SEQRES 18 C 1214 GLN PHE PRO LEU ASP TYR ASN TYR SER ALA PHE PHE LEU
SEQRES 19 C 1214 VAL ASP ASP GLY THR HIS GLY CYS LEU GLY GLY GLU ASN
SEQRES 20 C 1214 ARG PHE ARG LEU ARG LEU GLU SER TYR ILE SER GLN GLN
SEQRES 21 C 1214 LYS THR GLY VAL GLY GLY THR GLY ILE ASP ILE PRO VAL
SEQRES 22 C 1214 LEU LEU LEU LEU ILE ASP GLY ASP GLU LYS MET LEU THR
SEQRES 23 C 1214 ARG ILE GLU ASN ALA THR GLN ALA GLN LEU PRO CYS LEU
SEQRES 24 C 1214 LEU VAL ALA GLY SER GLY GLY ALA ALA ASP CYS LEU ALA
SEQRES 25 C 1214 GLU THR LEU GLU ASP THR LEU ALA PRO GLY SER GLY GLY
SEQRES 26 C 1214 ALA ARG GLN GLY GLU ALA ARG ASP ARG ILE ARG ARG PHE
SEQRES 27 C 1214 PHE PRO LYS GLY ASP LEU GLU VAL LEU GLN ALA GLN VAL
SEQRES 28 C 1214 GLU ARG ILE MET THR ARG LYS GLU LEU LEU THR VAL TYR
SEQRES 29 C 1214 SER SER GLU ASP GLY SER GLU GLU PHE GLU THR ILE VAL
SEQRES 30 C 1214 LEU LYS ALA LEU VAL LYS ALA CYS GLY SER SER GLU ALA
SEQRES 31 C 1214 SER ALA TYR LEU ASP GLU LEU ARG LEU ALA VAL ALA TRP
SEQRES 32 C 1214 ASN ARG VAL ASP ILE ALA GLN SER GLU LEU PHE ARG GLY
SEQRES 33 C 1214 ASP ILE GLN TRP ARG SER PHE HIS LEU GLU ALA SER LEU
SEQRES 34 C 1214 MET ASP ALA LEU LEU ASN ASP ARG PRO GLU PHE VAL ARG
SEQRES 35 C 1214 LEU LEU ILE SER HIS GLY LEU SER LEU GLY HIS PHE LEU
SEQRES 36 C 1214 THR PRO MET ARG LEU ALA GLN LEU TYR SER ALA ALA PRO
SEQRES 37 C 1214 SER ASN SER LEU ILE ARG ASN LEU LEU ASP GLN ALA SER
SEQRES 38 C 1214 HIS SER ALA GLY THR LYS ALA PRO ALA LEU LYS GLY GLY
SEQRES 39 C 1214 ALA ALA GLU LEU ARG PRO PRO ASP VAL GLY HIS VAL LEU
SEQRES 40 C 1214 ARG MET LEU LEU GLY LYS MET CYS ALA PRO ARG TYR PRO
SEQRES 41 C 1214 SER GLY GLY ALA TRP ASP PRO HIS PRO GLY GLN GLY PHE
SEQRES 42 C 1214 GLY GLU SER MET TYR LEU LEU SER ASP LYS ALA THR SER
SEQRES 43 C 1214 PRO LEU SER LEU ASP ALA GLY LEU GLY GLN ALA PRO TRP
SEQRES 44 C 1214 SER ASP LEU LEU LEU TRP ALA LEU LEU LEU ASN ARG ALA
SEQRES 45 C 1214 GLN MET ALA MET TYR PHE TRP GLU MET GLY SER ASN ALA
SEQRES 46 C 1214 VAL SER SER ALA LEU GLY ALA CYS LEU LEU LEU ARG VAL
SEQRES 47 C 1214 MET ALA ARG LEU GLU PRO ASP ALA GLU GLU ALA ALA ARG
SEQRES 48 C 1214 ARG LYS ASP LEU ALA PHE LYS PHE GLU GLY MET GLY VAL
SEQRES 49 C 1214 ASP LEU PHE GLY GLU CYS TYR ARG SER SER GLU VAL ARG
SEQRES 50 C 1214 ALA ALA ARG LEU LEU LEU ARG ARG CYS PRO LEU TRP GLY
SEQRES 51 C 1214 ASP ALA THR CYS LEU GLN LEU ALA MET GLN ALA ASP ALA
SEQRES 52 C 1214 ARG ALA PHE PHE ALA GLN ASP GLY VAL GLN SER LEU LEU
SEQRES 53 C 1214 THR GLN LYS TRP TRP GLY ASP MET ALA SER THR THR PRO
SEQRES 54 C 1214 ILE TRP ALA LEU VAL LEU ALA PHE PHE CYS PRO PRO LEU
SEQRES 55 C 1214 ILE TYR THR ARG LEU ILE THR PHE ARG LYS SER GLU GLU
SEQRES 56 C 1214 GLU PRO THR ARG GLU GLU LEU GLU PHE ASP MET ASP SER
SEQRES 57 C 1214 VAL ILE ASN GLY GLU GLY PRO VAL GLY THR ALA ASP PRO
SEQRES 58 C 1214 ALA GLU LYS THR PRO LEU GLY VAL PRO ARG GLN SER GLY
SEQRES 59 C 1214 ARG PRO GLY CYS CYS GLY GLY ARG CYS GLY GLY ARG ARG
SEQRES 60 C 1214 CYS LEU ARG ARG TRP PHE HIS PHE TRP GLY ALA PRO VAL
SEQRES 61 C 1214 THR ILE PHE MET GLY ASN VAL VAL SER TYR LEU LEU PHE
SEQRES 62 C 1214 LEU LEU LEU PHE SER ARG VAL LEU LEU VAL ASP PHE GLN
SEQRES 63 C 1214 PRO ALA PRO PRO GLY SER LEU GLU LEU LEU LEU TYR PHE
SEQRES 64 C 1214 TRP ALA PHE THR LEU LEU CYS GLU GLU LEU ARG GLN GLY
SEQRES 65 C 1214 LEU SER GLY GLY GLY GLY SER LEU ALA SER GLY GLY PRO
SEQRES 66 C 1214 GLY PRO GLY HIS ALA SER LEU SER GLN ARG LEU ARG LEU
SEQRES 67 C 1214 TYR LEU ALA ASP SER TRP ASN GLN CYS ASP LEU VAL ALA
SEQRES 68 C 1214 LEU THR CYS PHE LEU LEU GLY VAL GLY CYS ARG LEU THR
SEQRES 69 C 1214 PRO GLY LEU TYR HIS LEU GLY ARG THR VAL LEU CYS ILE
SEQRES 70 C 1214 ASP PHE MET VAL PHE THR VAL ARG LEU LEU HIS ILE PHE
SEQRES 71 C 1214 THR VAL ASN LYS GLN LEU GLY PRO LYS ILE VAL ILE VAL
SEQRES 72 C 1214 SER LYS MET MET LYS ASP VAL PHE PHE PHE LEU PHE PHE
SEQRES 73 C 1214 LEU GLY VAL TRP LEU VAL ALA TYR GLY VAL ALA THR GLU
SEQRES 74 C 1214 GLY LEU LEU ARG PRO ARG ASP SER ASP PHE PRO SER ILE
SEQRES 75 C 1214 LEU ARG ARG VAL PHE TYR ARG PRO TYR LEU GLN ILE PHE
SEQRES 76 C 1214 GLY GLN ILE PRO GLN GLU ASP MET ASP VAL ALA LEU MET
SEQRES 77 C 1214 GLU HIS SER ASN CYS SER SER GLU PRO GLY PHE TRP ALA
SEQRES 78 C 1214 HIS PRO PRO GLY ALA GLN ALA GLY THR CYS VAL SER GLN
SEQRES 79 C 1214 TYR ALA ASN TRP LEU VAL VAL LEU LEU LEU VAL ILE PHE
SEQRES 80 C 1214 LEU LEU VAL ALA ASN ILE LEU LEU VAL ASN LEU LEU ILE
SEQRES 81 C 1214 ALA MET PHE SER TYR THR PHE GLY LYS VAL GLN GLY ASN
SEQRES 82 C 1214 SER ASP LEU TYR TRP LYS ALA GLN ARG TYR ARG LEU ILE
SEQRES 83 C 1214 ARG GLU PHE HIS SER ARG PRO ALA LEU ALA PRO PRO PHE
SEQRES 84 C 1214 ILE VAL ILE SER HIS LEU ARG LEU LEU LEU ARG GLN LEU
SEQRES 85 C 1214 CYS ARG ARG PRO ARG SER PRO GLN PRO SER SER PRO ALA
SEQRES 86 C 1214 LEU GLU HIS PHE ARG VAL TYR LEU SER LYS GLU ALA GLU
SEQRES 87 C 1214 ARG LYS LEU LEU THR TRP GLU SER VAL HIS LYS GLU ASN
SEQRES 88 C 1214 PHE LEU LEU ALA ARG ALA ARG ASP LYS ARG GLU SER ASP
SEQRES 89 C 1214 SER GLU ARG LEU LYS ARG THR SER GLN LYS VAL ASP LEU
SEQRES 90 C 1214 ALA LEU LYS GLN LEU GLY HIS ILE ARG GLU TYR GLU GLN
SEQRES 91 C 1214 ARG LEU LYS VAL LEU GLU ARG GLU VAL GLN GLN CYS SER
SEQRES 92 C 1214 ARG VAL LEU GLY TRP VAL ALA GLU ALA LEU SER ARG SER
SEQRES 93 C 1214 ALA LEU LEU PRO PRO GLY GLY PRO PRO PRO PRO ASP LEU
SEQRES 94 C 1214 PRO GLY SER LYS ASP
SEQRES 1 D 1214 MET VAL VAL PRO GLU LYS GLU GLN SER TRP ILE PRO LYS
SEQRES 2 D 1214 ILE PHE LYS LYS LYS THR CYS THR THR PHE ILE VAL ASP
SEQRES 3 D 1214 SER THR ASP PRO GLY GLY THR LEU CYS GLN CYS GLY ARG
SEQRES 4 D 1214 PRO ARG THR ALA HIS PRO ALA VAL ALA MET GLU ASP ALA
SEQRES 5 D 1214 PHE GLY ALA ALA VAL VAL THR VAL TRP ASP SER ASP ALA
SEQRES 6 D 1214 HIS THR THR GLU LYS PRO THR ASP ALA TYR GLY GLU LEU
SEQRES 7 D 1214 ASP PHE THR GLY ALA GLY ARG LYS HIS SER ASN PHE LEU
SEQRES 8 D 1214 ARG LEU SER ASP ARG THR ASP PRO ALA ALA VAL TYR SER
SEQRES 9 D 1214 LEU VAL THR ARG THR TRP GLY PHE ARG ALA PRO ASN LEU
SEQRES 10 D 1214 VAL VAL SER VAL LEU GLY GLY SER GLY GLY PRO VAL LEU
SEQRES 11 D 1214 GLN THR TRP LEU GLN ASP LEU LEU ARG ARG GLY LEU VAL
SEQRES 12 D 1214 ARG ALA ALA GLN SER THR GLY ALA TRP ILE VAL THR GLY
SEQRES 13 D 1214 GLY LEU HIS THR GLY ILE GLY ARG HIS VAL GLY VAL ALA
SEQRES 14 D 1214 VAL ARG ASP HIS GLN MET ALA SER THR GLY GLY THR LYS
SEQRES 15 D 1214 VAL VAL ALA MET GLY VAL ALA PRO TRP GLY VAL VAL ARG
SEQRES 16 D 1214 ASN ARG ASP THR LEU ILE ASN PRO LYS GLY SER PHE PRO
SEQRES 17 D 1214 ALA ARG TYR ARG TRP ARG GLY ASP PRO GLU ASP GLY VAL
SEQRES 18 D 1214 GLN PHE PRO LEU ASP TYR ASN TYR SER ALA PHE PHE LEU
SEQRES 19 D 1214 VAL ASP ASP GLY THR HIS GLY CYS LEU GLY GLY GLU ASN
SEQRES 20 D 1214 ARG PHE ARG LEU ARG LEU GLU SER TYR ILE SER GLN GLN
SEQRES 21 D 1214 LYS THR GLY VAL GLY GLY THR GLY ILE ASP ILE PRO VAL
SEQRES 22 D 1214 LEU LEU LEU LEU ILE ASP GLY ASP GLU LYS MET LEU THR
SEQRES 23 D 1214 ARG ILE GLU ASN ALA THR GLN ALA GLN LEU PRO CYS LEU
SEQRES 24 D 1214 LEU VAL ALA GLY SER GLY GLY ALA ALA ASP CYS LEU ALA
SEQRES 25 D 1214 GLU THR LEU GLU ASP THR LEU ALA PRO GLY SER GLY GLY
SEQRES 26 D 1214 ALA ARG GLN GLY GLU ALA ARG ASP ARG ILE ARG ARG PHE
SEQRES 27 D 1214 PHE PRO LYS GLY ASP LEU GLU VAL LEU GLN ALA GLN VAL
SEQRES 28 D 1214 GLU ARG ILE MET THR ARG LYS GLU LEU LEU THR VAL TYR
SEQRES 29 D 1214 SER SER GLU ASP GLY SER GLU GLU PHE GLU THR ILE VAL
SEQRES 30 D 1214 LEU LYS ALA LEU VAL LYS ALA CYS GLY SER SER GLU ALA
SEQRES 31 D 1214 SER ALA TYR LEU ASP GLU LEU ARG LEU ALA VAL ALA TRP
SEQRES 32 D 1214 ASN ARG VAL ASP ILE ALA GLN SER GLU LEU PHE ARG GLY
SEQRES 33 D 1214 ASP ILE GLN TRP ARG SER PHE HIS LEU GLU ALA SER LEU
SEQRES 34 D 1214 MET ASP ALA LEU LEU ASN ASP ARG PRO GLU PHE VAL ARG
SEQRES 35 D 1214 LEU LEU ILE SER HIS GLY LEU SER LEU GLY HIS PHE LEU
SEQRES 36 D 1214 THR PRO MET ARG LEU ALA GLN LEU TYR SER ALA ALA PRO
SEQRES 37 D 1214 SER ASN SER LEU ILE ARG ASN LEU LEU ASP GLN ALA SER
SEQRES 38 D 1214 HIS SER ALA GLY THR LYS ALA PRO ALA LEU LYS GLY GLY
SEQRES 39 D 1214 ALA ALA GLU LEU ARG PRO PRO ASP VAL GLY HIS VAL LEU
SEQRES 40 D 1214 ARG MET LEU LEU GLY LYS MET CYS ALA PRO ARG TYR PRO
SEQRES 41 D 1214 SER GLY GLY ALA TRP ASP PRO HIS PRO GLY GLN GLY PHE
SEQRES 42 D 1214 GLY GLU SER MET TYR LEU LEU SER ASP LYS ALA THR SER
SEQRES 43 D 1214 PRO LEU SER LEU ASP ALA GLY LEU GLY GLN ALA PRO TRP
SEQRES 44 D 1214 SER ASP LEU LEU LEU TRP ALA LEU LEU LEU ASN ARG ALA
SEQRES 45 D 1214 GLN MET ALA MET TYR PHE TRP GLU MET GLY SER ASN ALA
SEQRES 46 D 1214 VAL SER SER ALA LEU GLY ALA CYS LEU LEU LEU ARG VAL
SEQRES 47 D 1214 MET ALA ARG LEU GLU PRO ASP ALA GLU GLU ALA ALA ARG
SEQRES 48 D 1214 ARG LYS ASP LEU ALA PHE LYS PHE GLU GLY MET GLY VAL
SEQRES 49 D 1214 ASP LEU PHE GLY GLU CYS TYR ARG SER SER GLU VAL ARG
SEQRES 50 D 1214 ALA ALA ARG LEU LEU LEU ARG ARG CYS PRO LEU TRP GLY
SEQRES 51 D 1214 ASP ALA THR CYS LEU GLN LEU ALA MET GLN ALA ASP ALA
SEQRES 52 D 1214 ARG ALA PHE PHE ALA GLN ASP GLY VAL GLN SER LEU LEU
SEQRES 53 D 1214 THR GLN LYS TRP TRP GLY ASP MET ALA SER THR THR PRO
SEQRES 54 D 1214 ILE TRP ALA LEU VAL LEU ALA PHE PHE CYS PRO PRO LEU
SEQRES 55 D 1214 ILE TYR THR ARG LEU ILE THR PHE ARG LYS SER GLU GLU
SEQRES 56 D 1214 GLU PRO THR ARG GLU GLU LEU GLU PHE ASP MET ASP SER
SEQRES 57 D 1214 VAL ILE ASN GLY GLU GLY PRO VAL GLY THR ALA ASP PRO
SEQRES 58 D 1214 ALA GLU LYS THR PRO LEU GLY VAL PRO ARG GLN SER GLY
SEQRES 59 D 1214 ARG PRO GLY CYS CYS GLY GLY ARG CYS GLY GLY ARG ARG
SEQRES 60 D 1214 CYS LEU ARG ARG TRP PHE HIS PHE TRP GLY ALA PRO VAL
SEQRES 61 D 1214 THR ILE PHE MET GLY ASN VAL VAL SER TYR LEU LEU PHE
SEQRES 62 D 1214 LEU LEU LEU PHE SER ARG VAL LEU LEU VAL ASP PHE GLN
SEQRES 63 D 1214 PRO ALA PRO PRO GLY SER LEU GLU LEU LEU LEU TYR PHE
SEQRES 64 D 1214 TRP ALA PHE THR LEU LEU CYS GLU GLU LEU ARG GLN GLY
SEQRES 65 D 1214 LEU SER GLY GLY GLY GLY SER LEU ALA SER GLY GLY PRO
SEQRES 66 D 1214 GLY PRO GLY HIS ALA SER LEU SER GLN ARG LEU ARG LEU
SEQRES 67 D 1214 TYR LEU ALA ASP SER TRP ASN GLN CYS ASP LEU VAL ALA
SEQRES 68 D 1214 LEU THR CYS PHE LEU LEU GLY VAL GLY CYS ARG LEU THR
SEQRES 69 D 1214 PRO GLY LEU TYR HIS LEU GLY ARG THR VAL LEU CYS ILE
SEQRES 70 D 1214 ASP PHE MET VAL PHE THR VAL ARG LEU LEU HIS ILE PHE
SEQRES 71 D 1214 THR VAL ASN LYS GLN LEU GLY PRO LYS ILE VAL ILE VAL
SEQRES 72 D 1214 SER LYS MET MET LYS ASP VAL PHE PHE PHE LEU PHE PHE
SEQRES 73 D 1214 LEU GLY VAL TRP LEU VAL ALA TYR GLY VAL ALA THR GLU
SEQRES 74 D 1214 GLY LEU LEU ARG PRO ARG ASP SER ASP PHE PRO SER ILE
SEQRES 75 D 1214 LEU ARG ARG VAL PHE TYR ARG PRO TYR LEU GLN ILE PHE
SEQRES 76 D 1214 GLY GLN ILE PRO GLN GLU ASP MET ASP VAL ALA LEU MET
SEQRES 77 D 1214 GLU HIS SER ASN CYS SER SER GLU PRO GLY PHE TRP ALA
SEQRES 78 D 1214 HIS PRO PRO GLY ALA GLN ALA GLY THR CYS VAL SER GLN
SEQRES 79 D 1214 TYR ALA ASN TRP LEU VAL VAL LEU LEU LEU VAL ILE PHE
SEQRES 80 D 1214 LEU LEU VAL ALA ASN ILE LEU LEU VAL ASN LEU LEU ILE
SEQRES 81 D 1214 ALA MET PHE SER TYR THR PHE GLY LYS VAL GLN GLY ASN
SEQRES 82 D 1214 SER ASP LEU TYR TRP LYS ALA GLN ARG TYR ARG LEU ILE
SEQRES 83 D 1214 ARG GLU PHE HIS SER ARG PRO ALA LEU ALA PRO PRO PHE
SEQRES 84 D 1214 ILE VAL ILE SER HIS LEU ARG LEU LEU LEU ARG GLN LEU
SEQRES 85 D 1214 CYS ARG ARG PRO ARG SER PRO GLN PRO SER SER PRO ALA
SEQRES 86 D 1214 LEU GLU HIS PHE ARG VAL TYR LEU SER LYS GLU ALA GLU
SEQRES 87 D 1214 ARG LYS LEU LEU THR TRP GLU SER VAL HIS LYS GLU ASN
SEQRES 88 D 1214 PHE LEU LEU ALA ARG ALA ARG ASP LYS ARG GLU SER ASP
SEQRES 89 D 1214 SER GLU ARG LEU LYS ARG THR SER GLN LYS VAL ASP LEU
SEQRES 90 D 1214 ALA LEU LYS GLN LEU GLY HIS ILE ARG GLU TYR GLU GLN
SEQRES 91 D 1214 ARG LEU LYS VAL LEU GLU ARG GLU VAL GLN GLN CYS SER
SEQRES 92 D 1214 ARG VAL LEU GLY TRP VAL ALA GLU ALA LEU SER ARG SER
SEQRES 93 D 1214 ALA LEU LEU PRO PRO GLY GLY PRO PRO PRO PRO ASP LEU
SEQRES 94 D 1214 PRO GLY SER LYS ASP
HET DVT A2001 38
HET DVT A2002 38
HET DVT B2001 38
HET DVT B2002 38
HET DVT C2001 38
HET DVT C2002 38
HET DVT D2001 38
HET DVT D2002 38
HETNAM DVT DECAVANADATE
FORMUL 5 DVT 8(O28 V10 6-)
HELIX 1 AA1 TRP A 10 PHE A 15 1 6
HELIX 2 AA2 ASP A 98 THR A 109 1 12
HELIX 3 AA3 GLN A 131 THR A 149 1 19
HELIX 4 AA4 ILE A 162 SER A 177 1 16
HELIX 5 AA5 ASN A 247 SER A 258 1 12
HELIX 6 AA6 LYS A 283 GLN A 295 1 13
HELIX 7 AA7 ALA A 308 GLU A 316 1 9
HELIX 8 AA8 GLN A 328 ASP A 333 1 6
HELIX 9 AA9 GLN A 348 ARG A 353 1 6
HELIX 10 AB1 GLU A 372 ALA A 384 1 13
HELIX 11 AB2 ASP A 395 TRP A 403 1 9
HELIX 12 AB3 VAL A 406 ARG A 415 1 10
HELIX 13 AB4 SER A 422 ASN A 435 1 14
HELIX 14 AB5 ARG A 437 HIS A 447 1 11
HELIX 15 AB6 SER A 450 LEU A 455 1 6
HELIX 16 AB7 THR A 456 ALA A 466 1 11
HELIX 17 AB8 LEU A 472 GLN A 479 1 8
HELIX 18 AB9 TRP A 559 LEU A 569 1 11
HELIX 19 AC1 ARG A 571 MET A 581 1 11
HELIX 20 AC2 ASN A 584 ALA A 600 1 17
HELIX 21 AC3 GLU A 608 ARG A 632 1 25
HELIX 22 AC4 SER A 634 ARG A 644 1 11
HELIX 23 AC5 PRO A 647 GLY A 650 5 4
HELIX 24 AC6 CYS A 654 GLN A 660 1 7
HELIX 25 AC7 ALA A 663 GLN A 669 1 7
HELIX 26 AC8 GLN A 669 TRP A 681 1 13
HELIX 27 AC9 PRO A 689 CYS A 699 1 11
HELIX 28 AD1 PRO A 700 ILE A 703 5 4
HELIX 29 AD2 ARG A 767 TRP A 776 1 10
HELIX 30 AD3 ALA A 778 VAL A 803 1 26
HELIX 31 AD4 GLY A 811 GLY A 835 1 25
HELIX 32 AD5 SER A 851 LEU A 860 1 10
HELIX 33 AD6 ASP A 862 THR A 884 1 23
HELIX 34 AD7 LEU A 887 ARG A 905 1 19
HELIX 35 AD8 LEU A 906 VAL A 912 5 7
HELIX 36 AD9 LEU A 916 LYS A 925 1 10
HELIX 37 AE1 ASP A 929 ARG A 953 1 25
HELIX 38 AE2 ASP A 958 LEU A 972 1 15
HELIX 39 AE3 ASN A 1017 LEU A 1034 1 18
HELIX 40 AE4 LEU A 1034 GLN A 1061 1 28
HELIX 41 AE5 GLN A 1061 ARG A 1072 1 12
HELIX 42 AE6 PHE A 1079 LEU A 1088 1 10
HELIX 43 AE7 SER A 1114 GLU A 1142 1 29
HELIX 44 AE8 GLU A 1146 GLY A 1163 1 18
HELIX 45 AE9 ILE A 1165 ALA A 1192 1 28
HELIX 46 AF1 TRP B 10 PHE B 15 1 6
HELIX 47 AF2 ASP B 98 THR B 109 1 12
HELIX 48 AF3 GLN B 131 THR B 149 1 19
HELIX 49 AF4 ILE B 162 SER B 177 1 16
HELIX 50 AF5 ASN B 247 SER B 258 1 12
HELIX 51 AF6 LYS B 283 GLN B 295 1 13
HELIX 52 AF7 ALA B 308 GLU B 316 1 9
HELIX 53 AF8 GLN B 328 ASP B 333 1 6
HELIX 54 AF9 GLN B 348 ARG B 353 1 6
HELIX 55 AG1 GLU B 372 ALA B 384 1 13
HELIX 56 AG2 ASP B 395 TRP B 403 1 9
HELIX 57 AG3 VAL B 406 ARG B 415 1 10
HELIX 58 AG4 SER B 422 ASN B 435 1 14
HELIX 59 AG5 ARG B 437 HIS B 447 1 11
HELIX 60 AG6 SER B 450 LEU B 455 1 6
HELIX 61 AG7 THR B 456 ALA B 466 1 11
HELIX 62 AG8 LEU B 472 GLN B 479 1 8
HELIX 63 AG9 TRP B 559 LEU B 569 1 11
HELIX 64 AH1 ARG B 571 MET B 581 1 11
HELIX 65 AH2 ASN B 584 ALA B 600 1 17
HELIX 66 AH3 GLU B 608 ARG B 632 1 25
HELIX 67 AH4 SER B 634 ARG B 644 1 11
HELIX 68 AH5 PRO B 647 GLY B 650 5 4
HELIX 69 AH6 CYS B 654 GLN B 660 1 7
HELIX 70 AH7 ALA B 663 GLN B 669 1 7
HELIX 71 AH8 GLN B 669 TRP B 681 1 13
HELIX 72 AH9 PRO B 689 CYS B 699 1 11
HELIX 73 AI1 PRO B 700 ILE B 703 5 4
HELIX 74 AI2 ARG B 767 TRP B 776 1 10
HELIX 75 AI3 ALA B 778 VAL B 803 1 26
HELIX 76 AI4 GLY B 811 GLY B 835 1 25
HELIX 77 AI5 SER B 851 LEU B 860 1 10
HELIX 78 AI6 ASP B 862 THR B 884 1 23
HELIX 79 AI7 LEU B 887 ARG B 905 1 19
HELIX 80 AI8 LEU B 906 VAL B 912 5 7
HELIX 81 AI9 LEU B 916 LYS B 925 1 10
HELIX 82 AJ1 ASP B 929 ARG B 953 1 25
HELIX 83 AJ2 ASP B 958 LEU B 972 1 15
HELIX 84 AJ3 ASN B 1017 LEU B 1034 1 18
HELIX 85 AJ4 LEU B 1034 GLN B 1061 1 28
HELIX 86 AJ5 GLN B 1061 ARG B 1072 1 12
HELIX 87 AJ6 PHE B 1079 LEU B 1088 1 10
HELIX 88 AJ7 SER B 1114 GLU B 1142 1 29
HELIX 89 AJ8 GLU B 1146 GLY B 1163 1 18
HELIX 90 AJ9 ILE B 1165 ALA B 1192 1 28
HELIX 91 AK1 TRP C 10 PHE C 15 1 6
HELIX 92 AK2 ASP C 98 THR C 109 1 12
HELIX 93 AK3 GLN C 131 THR C 149 1 19
HELIX 94 AK4 ILE C 162 SER C 177 1 16
HELIX 95 AK5 ASN C 247 SER C 258 1 12
HELIX 96 AK6 LYS C 283 GLN C 295 1 13
HELIX 97 AK7 ALA C 308 GLU C 316 1 9
HELIX 98 AK8 GLN C 328 ASP C 333 1 6
HELIX 99 AK9 GLN C 348 ARG C 353 1 6
HELIX 100 AL1 GLU C 372 ALA C 384 1 13
HELIX 101 AL2 ASP C 395 TRP C 403 1 9
HELIX 102 AL3 VAL C 406 ARG C 415 1 10
HELIX 103 AL4 SER C 422 ASN C 435 1 14
HELIX 104 AL5 ARG C 437 HIS C 447 1 11
HELIX 105 AL6 SER C 450 LEU C 455 1 6
HELIX 106 AL7 THR C 456 ALA C 466 1 11
HELIX 107 AL8 LEU C 472 GLN C 479 1 8
HELIX 108 AL9 TRP C 559 LEU C 569 1 11
HELIX 109 AM1 ARG C 571 MET C 581 1 11
HELIX 110 AM2 ASN C 584 ALA C 600 1 17
HELIX 111 AM3 GLU C 608 ARG C 632 1 25
HELIX 112 AM4 SER C 634 ARG C 644 1 11
HELIX 113 AM5 PRO C 647 GLY C 650 5 4
HELIX 114 AM6 CYS C 654 GLN C 660 1 7
HELIX 115 AM7 ALA C 663 GLN C 669 1 7
HELIX 116 AM8 GLN C 669 TRP C 681 1 13
HELIX 117 AM9 PRO C 689 CYS C 699 1 11
HELIX 118 AN1 PRO C 700 ILE C 703 5 4
HELIX 119 AN2 ARG C 767 TRP C 776 1 10
HELIX 120 AN3 ALA C 778 VAL C 803 1 26
HELIX 121 AN4 GLY C 811 GLY C 835 1 25
HELIX 122 AN5 SER C 851 LEU C 860 1 10
HELIX 123 AN6 ASP C 862 THR C 884 1 23
HELIX 124 AN7 LEU C 887 ARG C 905 1 19
HELIX 125 AN8 LEU C 906 VAL C 912 5 7
HELIX 126 AN9 LEU C 916 LYS C 925 1 10
HELIX 127 AO1 ASP C 929 ARG C 953 1 25
HELIX 128 AO2 ASP C 958 LEU C 972 1 15
HELIX 129 AO3 ASN C 1017 LEU C 1034 1 18
HELIX 130 AO4 LEU C 1034 GLN C 1061 1 28
HELIX 131 AO5 GLN C 1061 ARG C 1072 1 12
HELIX 132 AO6 PHE C 1079 LEU C 1088 1 10
HELIX 133 AO7 SER C 1114 GLU C 1142 1 29
HELIX 134 AO8 GLU C 1146 GLY C 1163 1 18
HELIX 135 AO9 ILE C 1165 ALA C 1192 1 28
HELIX 136 AP1 TRP D 10 PHE D 15 1 6
HELIX 137 AP2 ASP D 98 THR D 109 1 12
HELIX 138 AP3 GLN D 131 THR D 149 1 19
HELIX 139 AP4 ILE D 162 SER D 177 1 16
HELIX 140 AP5 ASN D 247 SER D 258 1 12
HELIX 141 AP6 LYS D 283 GLN D 295 1 13
HELIX 142 AP7 ALA D 308 GLU D 316 1 9
HELIX 143 AP8 GLN D 328 ASP D 333 1 6
HELIX 144 AP9 GLN D 348 ARG D 353 1 6
HELIX 145 AQ1 GLU D 372 ALA D 384 1 13
HELIX 146 AQ2 ASP D 395 TRP D 403 1 9
HELIX 147 AQ3 VAL D 406 ARG D 415 1 10
HELIX 148 AQ4 SER D 422 ASN D 435 1 14
HELIX 149 AQ5 ARG D 437 HIS D 447 1 11
HELIX 150 AQ6 SER D 450 LEU D 455 1 6
HELIX 151 AQ7 THR D 456 ALA D 466 1 11
HELIX 152 AQ8 LEU D 472 GLN D 479 1 8
HELIX 153 AQ9 TRP D 559 LEU D 569 1 11
HELIX 154 AR1 ARG D 571 MET D 581 1 11
HELIX 155 AR2 ASN D 584 ALA D 600 1 17
HELIX 156 AR3 GLU D 608 ARG D 632 1 25
HELIX 157 AR4 SER D 634 ARG D 644 1 11
HELIX 158 AR5 PRO D 647 GLY D 650 5 4
HELIX 159 AR6 CYS D 654 GLN D 660 1 7
HELIX 160 AR7 ALA D 663 GLN D 669 1 7
HELIX 161 AR8 GLN D 669 TRP D 681 1 13
HELIX 162 AR9 PRO D 689 CYS D 699 1 11
HELIX 163 AS1 PRO D 700 ILE D 703 5 4
HELIX 164 AS2 ARG D 767 TRP D 776 1 10
HELIX 165 AS3 ALA D 778 VAL D 803 1 26
HELIX 166 AS4 GLY D 811 GLY D 835 1 25
HELIX 167 AS5 SER D 851 LEU D 860 1 10
HELIX 168 AS6 ASP D 862 THR D 884 1 23
HELIX 169 AS7 LEU D 887 ARG D 905 1 19
HELIX 170 AS8 LEU D 906 VAL D 912 5 7
HELIX 171 AS9 LEU D 916 LYS D 925 1 10
HELIX 172 AT1 ASP D 929 ARG D 953 1 25
HELIX 173 AT2 ASP D 958 LEU D 972 1 15
HELIX 174 AT3 ASN D 1017 LEU D 1034 1 18
HELIX 175 AT4 LEU D 1034 GLN D 1061 1 28
HELIX 176 AT5 GLN D 1061 ARG D 1072 1 12
HELIX 177 AT6 PHE D 1079 LEU D 1088 1 10
HELIX 178 AT7 SER D 1114 GLU D 1142 1 29
HELIX 179 AT8 GLU D 1146 GLY D 1163 1 18
HELIX 180 AT9 ILE D 1165 ALA D 1192 1 28
SHEET 1 AA1 2 LYS A 16 LYS A 17 0
SHEET 2 AA1 2 LYS A 70 PRO A 71 -1 O LYS A 70 N LYS A 17
SHEET 1 AA2 8 TYR A 75 LEU A 78 0
SHEET 2 AA2 8 SER A 88 SER A 94 -1 O SER A 88 N LEU A 78
SHEET 3 AA2 8 ALA A 231 ASP A 236 1 O LEU A 234 N LEU A 91
SHEET 4 AA2 8 MET A 186 PRO A 190 1 N GLY A 187 O PHE A 233
SHEET 5 AA2 8 ALA A 151 GLY A 156 1 N ILE A 153 O MET A 186
SHEET 6 AA2 8 LEU A 117 VAL A 121 1 N LEU A 117 O TRP A 152
SHEET 7 AA2 8 VAL A 273 LEU A 277 1 O LEU A 274 N VAL A 118
SHEET 8 AA2 8 CYS A 298 VAL A 301 1 O LEU A 300 N LEU A 277
SHEET 1 AA3 2 ARG A 645 CYS A 646 0
SHEET 2 AA3 2 ALA A 652 THR A 653 -1 O ALA A 652 N CYS A 646
SHEET 1 AA4 2 TRP A1000 ALA A1001 0
SHEET 2 AA4 2 VAL A1012 SER A1013 -1 O VAL A1012 N ALA A1001
SHEET 1 AA5 2 LYS B 16 LYS B 17 0
SHEET 2 AA5 2 LYS B 70 PRO B 71 -1 O LYS B 70 N LYS B 17
SHEET 1 AA6 8 TYR B 75 LEU B 78 0
SHEET 2 AA6 8 SER B 88 SER B 94 -1 O SER B 88 N LEU B 78
SHEET 3 AA6 8 ALA B 231 ASP B 236 1 O LEU B 234 N LEU B 91
SHEET 4 AA6 8 MET B 186 PRO B 190 1 N GLY B 187 O PHE B 233
SHEET 5 AA6 8 ALA B 151 GLY B 156 1 N ILE B 153 O MET B 186
SHEET 6 AA6 8 LEU B 117 VAL B 121 1 N LEU B 117 O TRP B 152
SHEET 7 AA6 8 VAL B 273 LEU B 277 1 O LEU B 274 N VAL B 118
SHEET 8 AA6 8 CYS B 298 VAL B 301 1 O LEU B 300 N LEU B 277
SHEET 1 AA7 2 ARG B 645 CYS B 646 0
SHEET 2 AA7 2 ALA B 652 THR B 653 -1 O ALA B 652 N CYS B 646
SHEET 1 AA8 2 TRP B1000 ALA B1001 0
SHEET 2 AA8 2 VAL B1012 SER B1013 -1 O VAL B1012 N ALA B1001
SHEET 1 AA9 2 LYS C 16 LYS C 17 0
SHEET 2 AA9 2 LYS C 70 PRO C 71 -1 O LYS C 70 N LYS C 17
SHEET 1 AB1 8 TYR C 75 LEU C 78 0
SHEET 2 AB1 8 SER C 88 SER C 94 -1 O SER C 88 N LEU C 78
SHEET 3 AB1 8 ALA C 231 ASP C 236 1 O LEU C 234 N LEU C 91
SHEET 4 AB1 8 MET C 186 PRO C 190 1 N GLY C 187 O PHE C 233
SHEET 5 AB1 8 ALA C 151 GLY C 156 1 N ILE C 153 O MET C 186
SHEET 6 AB1 8 LEU C 117 VAL C 121 1 N LEU C 117 O TRP C 152
SHEET 7 AB1 8 VAL C 273 LEU C 277 1 O LEU C 274 N VAL C 118
SHEET 8 AB1 8 CYS C 298 VAL C 301 1 O LEU C 300 N LEU C 277
SHEET 1 AB2 2 ARG C 645 CYS C 646 0
SHEET 2 AB2 2 ALA C 652 THR C 653 -1 O ALA C 652 N CYS C 646
SHEET 1 AB3 2 TRP C1000 ALA C1001 0
SHEET 2 AB3 2 VAL C1012 SER C1013 -1 O VAL C1012 N ALA C1001
SHEET 1 AB4 2 LYS D 16 LYS D 17 0
SHEET 2 AB4 2 LYS D 70 PRO D 71 -1 O LYS D 70 N LYS D 17
SHEET 1 AB5 8 TYR D 75 LEU D 78 0
SHEET 2 AB5 8 SER D 88 SER D 94 -1 O SER D 88 N LEU D 78
SHEET 3 AB5 8 ALA D 231 ASP D 236 1 O LEU D 234 N LEU D 91
SHEET 4 AB5 8 MET D 186 PRO D 190 1 N GLY D 187 O PHE D 233
SHEET 5 AB5 8 ALA D 151 GLY D 156 1 N ILE D 153 O MET D 186
SHEET 6 AB5 8 LEU D 117 VAL D 121 1 N LEU D 117 O TRP D 152
SHEET 7 AB5 8 VAL D 273 LEU D 277 1 O LEU D 274 N VAL D 118
SHEET 8 AB5 8 CYS D 298 VAL D 301 1 O LEU D 300 N LEU D 277
SHEET 1 AB6 2 ARG D 645 CYS D 646 0
SHEET 2 AB6 2 ALA D 652 THR D 653 -1 O ALA D 652 N CYS D 646
SHEET 1 AB7 2 TRP D1000 ALA D1001 0
SHEET 2 AB7 2 VAL D1012 SER D1013 -1 O VAL D1012 N ALA D1001
SITE 1 AC1 5 ARG A1138 ARG A1141 ARG A1147 LYS A1154
SITE 2 AC1 5 LYS D1149
SITE 1 AC2 4 ARG A 421 PHE A 423 THR D 160 ARG D 214
SITE 1 AC3 5 LYS A1149 ARG B1138 ARG B1141 ARG B1147
SITE 2 AC3 5 LYS B1154
SITE 1 AC4 4 THR A 160 ARG A 214 ARG B 421 PHE B 423
SITE 1 AC5 5 LYS B1149 ARG C1138 ARG C1141 ARG C1147
SITE 2 AC5 5 LYS C1154
SITE 1 AC6 4 THR B 160 ARG B 214 ARG C 421 PHE C 423
SITE 1 AC7 5 LYS C1149 ARG D1138 ARG D1141 ARG D1147
SITE 2 AC7 5 LYS D1154
SITE 1 AC8 4 THR C 160 ARG C 214 ARG D 421 PHE D 423
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
