HEADER APOPTOSIS 24-DEC-16 5WVE
TITLE APAF-1-CASPASE-9 HOLOENZYME
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: APOPTOTIC PROTEASE-ACTIVATING FACTOR 1;
COMPND 3 CHAIN: A, C, E, G, I, K, M;
COMPND 4 SYNONYM: APAF-1;
COMPND 5 ENGINEERED: YES;
COMPND 6 MOL_ID: 2;
COMPND 7 MOLECULE: CYTOCHROME C;
COMPND 8 CHAIN: B, D, F, H, J, L, N;
COMPND 9 ENGINEERED: YES;
COMPND 10 MOL_ID: 3;
COMPND 11 MOLECULE: APOPTOTIC PROTEASE-ACTIVATING FACTOR 1;
COMPND 12 CHAIN: O, P, Q, R, W, X;
COMPND 13 FRAGMENT: CARD DOMAIN, UNP RESIDUES 1-102;
COMPND 14 SYNONYM: APAF-1;
COMPND 15 ENGINEERED: YES;
COMPND 16 MOL_ID: 4;
COMPND 17 MOLECULE: CASPASE;
COMPND 18 CHAIN: S, T, U, V, Y;
COMPND 19 FRAGMENT: CARD DOMAIN, UNP RESIDUES 1-100;
COMPND 20 SYNONYM: CASPASE-9;
COMPND 21 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: APAF1, KIAA0413;
SOURCE 6 EXPRESSION_SYSTEM: INSECT CELL EXPRESSION VECTOR PTIE1;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 266783;
SOURCE 8 MOL_ID: 2;
SOURCE 9 ORGANISM_SCIENTIFIC: EQUUS CABALLUS;
SOURCE 10 ORGANISM_COMMON: HORSE;
SOURCE 11 ORGANISM_TAXID: 9796;
SOURCE 12 GENE: CYCS, CYC;
SOURCE 13 EXPRESSION_SYSTEM: BACTERIA;
SOURCE 14 EXPRESSION_SYSTEM_TAXID: 2;
SOURCE 15 MOL_ID: 3;
SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 17 ORGANISM_COMMON: HUMAN;
SOURCE 18 ORGANISM_TAXID: 9606;
SOURCE 19 GENE: APAF1, KIAA0413;
SOURCE 20 EXPRESSION_SYSTEM: INSECT CELL EXPRESSION VECTOR PTIE1;
SOURCE 21 EXPRESSION_SYSTEM_TAXID: 266783;
SOURCE 22 MOL_ID: 4;
SOURCE 23 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 24 ORGANISM_COMMON: HUMAN;
SOURCE 25 ORGANISM_TAXID: 9606;
SOURCE 26 EXPRESSION_SYSTEM: BACTERIA;
SOURCE 27 EXPRESSION_SYSTEM_TAXID: 2
KEYWDS APOPTOSIS HOLOENZYME, APOPTOSIS
EXPDTA ELECTRON MICROSCOPY
AUTHOR Y.LI,M.ZHOU,Q.HU,Y.SHI
REVDAT 2 01-MAR-17 5WVE 1 JRNL
REVDAT 1 08-FEB-17 5WVE 0
JRNL AUTH Y.LI,M.ZHOU,Q.HU,X.-C.BAI,W.HUANG,S.H.W.SCHERES,Y.SHI
JRNL TITL MECHANISTIC INSIGHTS INTO CASPASE-9 ACTIVATION BY THE
JRNL TITL 2 STRUCTURE OF THE APOPTOSOME HOLOENZYME
JRNL REF PROC. NATL. ACAD. SCI. V. 114 1542 2017
JRNL REF 2 U.S.A.
JRNL REFN ESSN 1091-6490
JRNL PMID 28143931
JRNL DOI 10.1073/PNAS.1620626114
REMARK 2
REMARK 2 RESOLUTION. 4.40 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : NULL
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.400
REMARK 3 NUMBER OF PARTICLES : 240130
REMARK 3 CTF CORRECTION METHOD : NONE
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 5WVE COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 05-JAN-17.
REMARK 100 THE DEPOSITION ID IS D_1300002450.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : APAF-1 APOPTOSOME; APAF-1;
REMARK 245 CYTOCHROME C; APAF-1 CARD;
REMARK 245 CASPASE-9 CARD
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.50
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI POLARA 300
REMARK 245 DETECTOR TYPE : FEI FALCON II (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 32.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 25-MERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,
REMARK 350 AND CHAINS: K, L, M, N, O, P, Q, R, S,
REMARK 350 AND CHAINS: T, U, V, W, X, Y
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 ASP A 2
REMARK 465 ALA A 3
REMARK 465 LYS A 4
REMARK 465 ALA A 5
REMARK 465 ARG A 6
REMARK 465 ASN A 7
REMARK 465 CYS A 8
REMARK 465 LEU A 9
REMARK 465 LEU A 10
REMARK 465 GLN A 11
REMARK 465 HIS A 12
REMARK 465 ARG A 13
REMARK 465 GLU A 14
REMARK 465 ALA A 15
REMARK 465 LEU A 16
REMARK 465 GLU A 17
REMARK 465 LYS A 18
REMARK 465 ASP A 19
REMARK 465 ILE A 20
REMARK 465 LYS A 21
REMARK 465 THR A 22
REMARK 465 SER A 23
REMARK 465 TYR A 24
REMARK 465 ILE A 25
REMARK 465 MET A 26
REMARK 465 ASP A 27
REMARK 465 HIS A 28
REMARK 465 MET A 29
REMARK 465 ILE A 30
REMARK 465 SER A 31
REMARK 465 ASP A 32
REMARK 465 GLY A 33
REMARK 465 PHE A 34
REMARK 465 LEU A 35
REMARK 465 THR A 36
REMARK 465 ILE A 37
REMARK 465 SER A 38
REMARK 465 GLU A 39
REMARK 465 GLU A 40
REMARK 465 GLU A 41
REMARK 465 LYS A 42
REMARK 465 VAL A 43
REMARK 465 ARG A 44
REMARK 465 ASN A 45
REMARK 465 GLU A 46
REMARK 465 PRO A 47
REMARK 465 THR A 48
REMARK 465 GLN A 49
REMARK 465 GLN A 50
REMARK 465 GLN A 51
REMARK 465 ARG A 52
REMARK 465 ALA A 53
REMARK 465 ALA A 54
REMARK 465 MET A 55
REMARK 465 LEU A 56
REMARK 465 ILE A 57
REMARK 465 LYS A 58
REMARK 465 MET A 59
REMARK 465 ILE A 60
REMARK 465 LEU A 61
REMARK 465 LYS A 62
REMARK 465 LYS A 63
REMARK 465 ASP A 64
REMARK 465 ASN A 65
REMARK 465 ASP A 66
REMARK 465 SER A 67
REMARK 465 TYR A 68
REMARK 465 VAL A 69
REMARK 465 SER A 70
REMARK 465 PHE A 71
REMARK 465 TYR A 72
REMARK 465 ASN A 73
REMARK 465 ALA A 74
REMARK 465 LEU A 75
REMARK 465 LEU A 76
REMARK 465 HIS A 77
REMARK 465 GLU A 78
REMARK 465 GLY A 79
REMARK 465 TYR A 80
REMARK 465 LYS A 81
REMARK 465 ASP A 82
REMARK 465 LEU A 83
REMARK 465 ALA A 84
REMARK 465 ALA A 85
REMARK 465 LEU A 86
REMARK 465 LEU A 87
REMARK 465 HIS A 88
REMARK 465 ASP A 89
REMARK 465 GLY A 90
REMARK 465 ILE A 91
REMARK 465 PRO A 92
REMARK 465 VAL A 93
REMARK 465 VAL A 94
REMARK 465 SER A 95
REMARK 465 SER A 96
REMARK 465 SER A 97
REMARK 465 SER A 98
REMARK 465 GLY A 99
REMARK 465 LYS A 100
REMARK 465 ASP A 101
REMARK 465 SER A 102
REMARK 465 VAL A 103
REMARK 465 SER A 104
REMARK 465 MET B 0
REMARK 465 MET C 1
REMARK 465 ASP C 2
REMARK 465 ALA C 3
REMARK 465 LYS C 4
REMARK 465 ALA C 5
REMARK 465 ARG C 6
REMARK 465 ASN C 7
REMARK 465 CYS C 8
REMARK 465 LEU C 9
REMARK 465 LEU C 10
REMARK 465 GLN C 11
REMARK 465 HIS C 12
REMARK 465 ARG C 13
REMARK 465 GLU C 14
REMARK 465 ALA C 15
REMARK 465 LEU C 16
REMARK 465 GLU C 17
REMARK 465 LYS C 18
REMARK 465 ASP C 19
REMARK 465 ILE C 20
REMARK 465 LYS C 21
REMARK 465 THR C 22
REMARK 465 SER C 23
REMARK 465 TYR C 24
REMARK 465 ILE C 25
REMARK 465 MET C 26
REMARK 465 ASP C 27
REMARK 465 HIS C 28
REMARK 465 MET C 29
REMARK 465 ILE C 30
REMARK 465 SER C 31
REMARK 465 ASP C 32
REMARK 465 GLY C 33
REMARK 465 PHE C 34
REMARK 465 LEU C 35
REMARK 465 THR C 36
REMARK 465 ILE C 37
REMARK 465 SER C 38
REMARK 465 GLU C 39
REMARK 465 GLU C 40
REMARK 465 GLU C 41
REMARK 465 LYS C 42
REMARK 465 VAL C 43
REMARK 465 ARG C 44
REMARK 465 ASN C 45
REMARK 465 GLU C 46
REMARK 465 PRO C 47
REMARK 465 THR C 48
REMARK 465 GLN C 49
REMARK 465 GLN C 50
REMARK 465 GLN C 51
REMARK 465 ARG C 52
REMARK 465 ALA C 53
REMARK 465 ALA C 54
REMARK 465 MET C 55
REMARK 465 LEU C 56
REMARK 465 ILE C 57
REMARK 465 LYS C 58
REMARK 465 MET C 59
REMARK 465 ILE C 60
REMARK 465 LEU C 61
REMARK 465 LYS C 62
REMARK 465 LYS C 63
REMARK 465 ASP C 64
REMARK 465 ASN C 65
REMARK 465 ASP C 66
REMARK 465 SER C 67
REMARK 465 TYR C 68
REMARK 465 VAL C 69
REMARK 465 SER C 70
REMARK 465 PHE C 71
REMARK 465 TYR C 72
REMARK 465 ASN C 73
REMARK 465 ALA C 74
REMARK 465 LEU C 75
REMARK 465 LEU C 76
REMARK 465 HIS C 77
REMARK 465 GLU C 78
REMARK 465 GLY C 79
REMARK 465 TYR C 80
REMARK 465 LYS C 81
REMARK 465 ASP C 82
REMARK 465 LEU C 83
REMARK 465 ALA C 84
REMARK 465 ALA C 85
REMARK 465 LEU C 86
REMARK 465 LEU C 87
REMARK 465 HIS C 88
REMARK 465 ASP C 89
REMARK 465 GLY C 90
REMARK 465 ILE C 91
REMARK 465 PRO C 92
REMARK 465 VAL C 93
REMARK 465 VAL C 94
REMARK 465 SER C 95
REMARK 465 SER C 96
REMARK 465 SER C 97
REMARK 465 SER C 98
REMARK 465 GLY C 99
REMARK 465 LYS C 100
REMARK 465 ASP C 101
REMARK 465 SER C 102
REMARK 465 VAL C 103
REMARK 465 SER C 104
REMARK 465 MET D 0
REMARK 465 MET E 1
REMARK 465 ASP E 2
REMARK 465 ALA E 3
REMARK 465 LYS E 4
REMARK 465 ALA E 5
REMARK 465 ARG E 6
REMARK 465 ASN E 7
REMARK 465 CYS E 8
REMARK 465 LEU E 9
REMARK 465 LEU E 10
REMARK 465 GLN E 11
REMARK 465 HIS E 12
REMARK 465 ARG E 13
REMARK 465 GLU E 14
REMARK 465 ALA E 15
REMARK 465 LEU E 16
REMARK 465 GLU E 17
REMARK 465 LYS E 18
REMARK 465 ASP E 19
REMARK 465 ILE E 20
REMARK 465 LYS E 21
REMARK 465 THR E 22
REMARK 465 SER E 23
REMARK 465 TYR E 24
REMARK 465 ILE E 25
REMARK 465 MET E 26
REMARK 465 ASP E 27
REMARK 465 HIS E 28
REMARK 465 MET E 29
REMARK 465 ILE E 30
REMARK 465 SER E 31
REMARK 465 ASP E 32
REMARK 465 GLY E 33
REMARK 465 PHE E 34
REMARK 465 LEU E 35
REMARK 465 THR E 36
REMARK 465 ILE E 37
REMARK 465 SER E 38
REMARK 465 GLU E 39
REMARK 465 GLU E 40
REMARK 465 GLU E 41
REMARK 465 LYS E 42
REMARK 465 VAL E 43
REMARK 465 ARG E 44
REMARK 465 ASN E 45
REMARK 465 GLU E 46
REMARK 465 PRO E 47
REMARK 465 THR E 48
REMARK 465 GLN E 49
REMARK 465 GLN E 50
REMARK 465 GLN E 51
REMARK 465 ARG E 52
REMARK 465 ALA E 53
REMARK 465 ALA E 54
REMARK 465 MET E 55
REMARK 465 LEU E 56
REMARK 465 ILE E 57
REMARK 465 LYS E 58
REMARK 465 MET E 59
REMARK 465 ILE E 60
REMARK 465 LEU E 61
REMARK 465 LYS E 62
REMARK 465 LYS E 63
REMARK 465 ASP E 64
REMARK 465 ASN E 65
REMARK 465 ASP E 66
REMARK 465 SER E 67
REMARK 465 TYR E 68
REMARK 465 VAL E 69
REMARK 465 SER E 70
REMARK 465 PHE E 71
REMARK 465 TYR E 72
REMARK 465 ASN E 73
REMARK 465 ALA E 74
REMARK 465 LEU E 75
REMARK 465 LEU E 76
REMARK 465 HIS E 77
REMARK 465 GLU E 78
REMARK 465 GLY E 79
REMARK 465 TYR E 80
REMARK 465 LYS E 81
REMARK 465 ASP E 82
REMARK 465 LEU E 83
REMARK 465 ALA E 84
REMARK 465 ALA E 85
REMARK 465 LEU E 86
REMARK 465 LEU E 87
REMARK 465 HIS E 88
REMARK 465 ASP E 89
REMARK 465 GLY E 90
REMARK 465 ILE E 91
REMARK 465 PRO E 92
REMARK 465 VAL E 93
REMARK 465 VAL E 94
REMARK 465 SER E 95
REMARK 465 SER E 96
REMARK 465 SER E 97
REMARK 465 SER E 98
REMARK 465 GLY E 99
REMARK 465 LYS E 100
REMARK 465 ASP E 101
REMARK 465 SER E 102
REMARK 465 VAL E 103
REMARK 465 SER E 104
REMARK 465 MET F 0
REMARK 465 MET G 1
REMARK 465 ASP G 2
REMARK 465 ALA G 3
REMARK 465 LYS G 4
REMARK 465 ALA G 5
REMARK 465 ARG G 6
REMARK 465 ASN G 7
REMARK 465 CYS G 8
REMARK 465 LEU G 9
REMARK 465 LEU G 10
REMARK 465 GLN G 11
REMARK 465 HIS G 12
REMARK 465 ARG G 13
REMARK 465 GLU G 14
REMARK 465 ALA G 15
REMARK 465 LEU G 16
REMARK 465 GLU G 17
REMARK 465 LYS G 18
REMARK 465 ASP G 19
REMARK 465 ILE G 20
REMARK 465 LYS G 21
REMARK 465 THR G 22
REMARK 465 SER G 23
REMARK 465 TYR G 24
REMARK 465 ILE G 25
REMARK 465 MET G 26
REMARK 465 ASP G 27
REMARK 465 HIS G 28
REMARK 465 MET G 29
REMARK 465 ILE G 30
REMARK 465 SER G 31
REMARK 465 ASP G 32
REMARK 465 GLY G 33
REMARK 465 PHE G 34
REMARK 465 LEU G 35
REMARK 465 THR G 36
REMARK 465 ILE G 37
REMARK 465 SER G 38
REMARK 465 GLU G 39
REMARK 465 GLU G 40
REMARK 465 GLU G 41
REMARK 465 LYS G 42
REMARK 465 VAL G 43
REMARK 465 ARG G 44
REMARK 465 ASN G 45
REMARK 465 GLU G 46
REMARK 465 PRO G 47
REMARK 465 THR G 48
REMARK 465 GLN G 49
REMARK 465 GLN G 50
REMARK 465 GLN G 51
REMARK 465 ARG G 52
REMARK 465 ALA G 53
REMARK 465 ALA G 54
REMARK 465 MET G 55
REMARK 465 LEU G 56
REMARK 465 ILE G 57
REMARK 465 LYS G 58
REMARK 465 MET G 59
REMARK 465 ILE G 60
REMARK 465 LEU G 61
REMARK 465 LYS G 62
REMARK 465 LYS G 63
REMARK 465 ASP G 64
REMARK 465 ASN G 65
REMARK 465 ASP G 66
REMARK 465 SER G 67
REMARK 465 TYR G 68
REMARK 465 VAL G 69
REMARK 465 SER G 70
REMARK 465 PHE G 71
REMARK 465 TYR G 72
REMARK 465 ASN G 73
REMARK 465 ALA G 74
REMARK 465 LEU G 75
REMARK 465 LEU G 76
REMARK 465 HIS G 77
REMARK 465 GLU G 78
REMARK 465 GLY G 79
REMARK 465 TYR G 80
REMARK 465 LYS G 81
REMARK 465 ASP G 82
REMARK 465 LEU G 83
REMARK 465 ALA G 84
REMARK 465 ALA G 85
REMARK 465 LEU G 86
REMARK 465 LEU G 87
REMARK 465 HIS G 88
REMARK 465 ASP G 89
REMARK 465 GLY G 90
REMARK 465 ILE G 91
REMARK 465 PRO G 92
REMARK 465 VAL G 93
REMARK 465 VAL G 94
REMARK 465 SER G 95
REMARK 465 SER G 96
REMARK 465 SER G 97
REMARK 465 SER G 98
REMARK 465 GLY G 99
REMARK 465 LYS G 100
REMARK 465 ASP G 101
REMARK 465 SER G 102
REMARK 465 VAL G 103
REMARK 465 SER G 104
REMARK 465 MET H 0
REMARK 465 MET I 1
REMARK 465 ASP I 2
REMARK 465 ALA I 3
REMARK 465 LYS I 4
REMARK 465 ALA I 5
REMARK 465 ARG I 6
REMARK 465 ASN I 7
REMARK 465 CYS I 8
REMARK 465 LEU I 9
REMARK 465 LEU I 10
REMARK 465 GLN I 11
REMARK 465 HIS I 12
REMARK 465 ARG I 13
REMARK 465 GLU I 14
REMARK 465 ALA I 15
REMARK 465 LEU I 16
REMARK 465 GLU I 17
REMARK 465 LYS I 18
REMARK 465 ASP I 19
REMARK 465 ILE I 20
REMARK 465 LYS I 21
REMARK 465 THR I 22
REMARK 465 SER I 23
REMARK 465 TYR I 24
REMARK 465 ILE I 25
REMARK 465 MET I 26
REMARK 465 ASP I 27
REMARK 465 HIS I 28
REMARK 465 MET I 29
REMARK 465 ILE I 30
REMARK 465 SER I 31
REMARK 465 ASP I 32
REMARK 465 GLY I 33
REMARK 465 PHE I 34
REMARK 465 LEU I 35
REMARK 465 THR I 36
REMARK 465 ILE I 37
REMARK 465 SER I 38
REMARK 465 GLU I 39
REMARK 465 GLU I 40
REMARK 465 GLU I 41
REMARK 465 LYS I 42
REMARK 465 VAL I 43
REMARK 465 ARG I 44
REMARK 465 ASN I 45
REMARK 465 GLU I 46
REMARK 465 PRO I 47
REMARK 465 THR I 48
REMARK 465 GLN I 49
REMARK 465 GLN I 50
REMARK 465 GLN I 51
REMARK 465 ARG I 52
REMARK 465 ALA I 53
REMARK 465 ALA I 54
REMARK 465 MET I 55
REMARK 465 LEU I 56
REMARK 465 ILE I 57
REMARK 465 LYS I 58
REMARK 465 MET I 59
REMARK 465 ILE I 60
REMARK 465 LEU I 61
REMARK 465 LYS I 62
REMARK 465 LYS I 63
REMARK 465 ASP I 64
REMARK 465 ASN I 65
REMARK 465 ASP I 66
REMARK 465 SER I 67
REMARK 465 TYR I 68
REMARK 465 VAL I 69
REMARK 465 SER I 70
REMARK 465 PHE I 71
REMARK 465 TYR I 72
REMARK 465 ASN I 73
REMARK 465 ALA I 74
REMARK 465 LEU I 75
REMARK 465 LEU I 76
REMARK 465 HIS I 77
REMARK 465 GLU I 78
REMARK 465 GLY I 79
REMARK 465 TYR I 80
REMARK 465 LYS I 81
REMARK 465 ASP I 82
REMARK 465 LEU I 83
REMARK 465 ALA I 84
REMARK 465 ALA I 85
REMARK 465 LEU I 86
REMARK 465 LEU I 87
REMARK 465 HIS I 88
REMARK 465 ASP I 89
REMARK 465 GLY I 90
REMARK 465 ILE I 91
REMARK 465 PRO I 92
REMARK 465 VAL I 93
REMARK 465 VAL I 94
REMARK 465 SER I 95
REMARK 465 SER I 96
REMARK 465 SER I 97
REMARK 465 SER I 98
REMARK 465 GLY I 99
REMARK 465 LYS I 100
REMARK 465 ASP I 101
REMARK 465 SER I 102
REMARK 465 VAL I 103
REMARK 465 SER I 104
REMARK 465 MET J 0
REMARK 465 MET K 1
REMARK 465 ASP K 2
REMARK 465 ALA K 3
REMARK 465 LYS K 4
REMARK 465 ALA K 5
REMARK 465 ARG K 6
REMARK 465 ASN K 7
REMARK 465 CYS K 8
REMARK 465 LEU K 9
REMARK 465 LEU K 10
REMARK 465 GLN K 11
REMARK 465 HIS K 12
REMARK 465 ARG K 13
REMARK 465 GLU K 14
REMARK 465 ALA K 15
REMARK 465 LEU K 16
REMARK 465 GLU K 17
REMARK 465 LYS K 18
REMARK 465 ASP K 19
REMARK 465 ILE K 20
REMARK 465 LYS K 21
REMARK 465 THR K 22
REMARK 465 SER K 23
REMARK 465 TYR K 24
REMARK 465 ILE K 25
REMARK 465 MET K 26
REMARK 465 ASP K 27
REMARK 465 HIS K 28
REMARK 465 MET K 29
REMARK 465 ILE K 30
REMARK 465 SER K 31
REMARK 465 ASP K 32
REMARK 465 GLY K 33
REMARK 465 PHE K 34
REMARK 465 LEU K 35
REMARK 465 THR K 36
REMARK 465 ILE K 37
REMARK 465 SER K 38
REMARK 465 GLU K 39
REMARK 465 GLU K 40
REMARK 465 GLU K 41
REMARK 465 LYS K 42
REMARK 465 VAL K 43
REMARK 465 ARG K 44
REMARK 465 ASN K 45
REMARK 465 GLU K 46
REMARK 465 PRO K 47
REMARK 465 THR K 48
REMARK 465 GLN K 49
REMARK 465 GLN K 50
REMARK 465 GLN K 51
REMARK 465 ARG K 52
REMARK 465 ALA K 53
REMARK 465 ALA K 54
REMARK 465 MET K 55
REMARK 465 LEU K 56
REMARK 465 ILE K 57
REMARK 465 LYS K 58
REMARK 465 MET K 59
REMARK 465 ILE K 60
REMARK 465 LEU K 61
REMARK 465 LYS K 62
REMARK 465 LYS K 63
REMARK 465 ASP K 64
REMARK 465 ASN K 65
REMARK 465 ASP K 66
REMARK 465 SER K 67
REMARK 465 TYR K 68
REMARK 465 VAL K 69
REMARK 465 SER K 70
REMARK 465 PHE K 71
REMARK 465 TYR K 72
REMARK 465 ASN K 73
REMARK 465 ALA K 74
REMARK 465 LEU K 75
REMARK 465 LEU K 76
REMARK 465 HIS K 77
REMARK 465 GLU K 78
REMARK 465 GLY K 79
REMARK 465 TYR K 80
REMARK 465 LYS K 81
REMARK 465 ASP K 82
REMARK 465 LEU K 83
REMARK 465 ALA K 84
REMARK 465 ALA K 85
REMARK 465 LEU K 86
REMARK 465 LEU K 87
REMARK 465 HIS K 88
REMARK 465 ASP K 89
REMARK 465 GLY K 90
REMARK 465 ILE K 91
REMARK 465 PRO K 92
REMARK 465 VAL K 93
REMARK 465 VAL K 94
REMARK 465 SER K 95
REMARK 465 SER K 96
REMARK 465 SER K 97
REMARK 465 SER K 98
REMARK 465 GLY K 99
REMARK 465 LYS K 100
REMARK 465 ASP K 101
REMARK 465 SER K 102
REMARK 465 VAL K 103
REMARK 465 SER K 104
REMARK 465 MET L 0
REMARK 465 MET M 1
REMARK 465 ASP M 2
REMARK 465 ALA M 3
REMARK 465 LYS M 4
REMARK 465 ALA M 5
REMARK 465 ARG M 6
REMARK 465 ASN M 7
REMARK 465 CYS M 8
REMARK 465 LEU M 9
REMARK 465 LEU M 10
REMARK 465 GLN M 11
REMARK 465 HIS M 12
REMARK 465 ARG M 13
REMARK 465 GLU M 14
REMARK 465 ALA M 15
REMARK 465 LEU M 16
REMARK 465 GLU M 17
REMARK 465 LYS M 18
REMARK 465 ASP M 19
REMARK 465 ILE M 20
REMARK 465 LYS M 21
REMARK 465 THR M 22
REMARK 465 SER M 23
REMARK 465 TYR M 24
REMARK 465 ILE M 25
REMARK 465 MET M 26
REMARK 465 ASP M 27
REMARK 465 HIS M 28
REMARK 465 MET M 29
REMARK 465 ILE M 30
REMARK 465 SER M 31
REMARK 465 ASP M 32
REMARK 465 GLY M 33
REMARK 465 PHE M 34
REMARK 465 LEU M 35
REMARK 465 THR M 36
REMARK 465 ILE M 37
REMARK 465 SER M 38
REMARK 465 GLU M 39
REMARK 465 GLU M 40
REMARK 465 GLU M 41
REMARK 465 LYS M 42
REMARK 465 VAL M 43
REMARK 465 ARG M 44
REMARK 465 ASN M 45
REMARK 465 GLU M 46
REMARK 465 PRO M 47
REMARK 465 THR M 48
REMARK 465 GLN M 49
REMARK 465 GLN M 50
REMARK 465 GLN M 51
REMARK 465 ARG M 52
REMARK 465 ALA M 53
REMARK 465 ALA M 54
REMARK 465 MET M 55
REMARK 465 LEU M 56
REMARK 465 ILE M 57
REMARK 465 LYS M 58
REMARK 465 MET M 59
REMARK 465 ILE M 60
REMARK 465 LEU M 61
REMARK 465 LYS M 62
REMARK 465 LYS M 63
REMARK 465 ASP M 64
REMARK 465 ASN M 65
REMARK 465 ASP M 66
REMARK 465 SER M 67
REMARK 465 TYR M 68
REMARK 465 VAL M 69
REMARK 465 SER M 70
REMARK 465 PHE M 71
REMARK 465 TYR M 72
REMARK 465 ASN M 73
REMARK 465 ALA M 74
REMARK 465 LEU M 75
REMARK 465 LEU M 76
REMARK 465 HIS M 77
REMARK 465 GLU M 78
REMARK 465 GLY M 79
REMARK 465 TYR M 80
REMARK 465 LYS M 81
REMARK 465 ASP M 82
REMARK 465 LEU M 83
REMARK 465 ALA M 84
REMARK 465 ALA M 85
REMARK 465 LEU M 86
REMARK 465 LEU M 87
REMARK 465 HIS M 88
REMARK 465 ASP M 89
REMARK 465 GLY M 90
REMARK 465 ILE M 91
REMARK 465 PRO M 92
REMARK 465 VAL M 93
REMARK 465 VAL M 94
REMARK 465 SER M 95
REMARK 465 SER M 96
REMARK 465 SER M 97
REMARK 465 SER M 98
REMARK 465 GLY M 99
REMARK 465 LYS M 100
REMARK 465 ASP M 101
REMARK 465 SER M 102
REMARK 465 VAL M 103
REMARK 465 SER M 104
REMARK 465 MET N 0
REMARK 465 PRO O 92
REMARK 465 VAL O 93
REMARK 465 VAL O 94
REMARK 465 SER O 95
REMARK 465 SER O 96
REMARK 465 SER O 97
REMARK 465 SER O 98
REMARK 465 GLY O 99
REMARK 465 LYS O 100
REMARK 465 ASP O 101
REMARK 465 SER O 102
REMARK 465 PRO P 92
REMARK 465 VAL P 93
REMARK 465 VAL P 94
REMARK 465 SER P 95
REMARK 465 SER P 96
REMARK 465 SER P 97
REMARK 465 SER P 98
REMARK 465 GLY P 99
REMARK 465 LYS P 100
REMARK 465 ASP P 101
REMARK 465 SER P 102
REMARK 465 PRO Q 92
REMARK 465 VAL Q 93
REMARK 465 VAL Q 94
REMARK 465 SER Q 95
REMARK 465 SER Q 96
REMARK 465 SER Q 97
REMARK 465 SER Q 98
REMARK 465 GLY Q 99
REMARK 465 LYS Q 100
REMARK 465 ASP Q 101
REMARK 465 SER Q 102
REMARK 465 PRO R 92
REMARK 465 VAL R 93
REMARK 465 VAL R 94
REMARK 465 SER R 95
REMARK 465 SER R 96
REMARK 465 SER R 97
REMARK 465 SER R 98
REMARK 465 GLY R 99
REMARK 465 LYS R 100
REMARK 465 ASP R 101
REMARK 465 SER R 102
REMARK 465 LYS S 97
REMARK 465 LEU S 98
REMARK 465 SER S 99
REMARK 465 LYS S 100
REMARK 465 LYS T 97
REMARK 465 LEU T 98
REMARK 465 SER T 99
REMARK 465 LYS T 100
REMARK 465 LYS U 97
REMARK 465 LEU U 98
REMARK 465 SER U 99
REMARK 465 LYS U 100
REMARK 465 LYS V 97
REMARK 465 LEU V 98
REMARK 465 SER V 99
REMARK 465 LYS V 100
REMARK 465 SER W 96
REMARK 465 SER W 97
REMARK 465 SER W 98
REMARK 465 GLY W 99
REMARK 465 LYS W 100
REMARK 465 ASP W 101
REMARK 465 SER W 102
REMARK 465 VAL X 93
REMARK 465 VAL X 94
REMARK 465 SER X 95
REMARK 465 SER X 96
REMARK 465 SER X 97
REMARK 465 SER X 98
REMARK 465 GLY X 99
REMARK 465 LYS X 100
REMARK 465 ASP X 101
REMARK 465 SER X 102
REMARK 465 ALA Y 96
REMARK 465 LYS Y 97
REMARK 465 LEU Y 98
REMARK 465 SER Y 99
REMARK 465 LYS Y 100
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 ALA S 96 CB
REMARK 470 ALA T 96 CB
REMARK 470 ALA U 96 CB
REMARK 470 ALA V 96 CB
REMARK 470 VAL Y 28 CG1 CG2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 O TRP E 483 CB LEU E 487 1.82
REMARK 500 O TRP C 483 CB LEU C 487 1.82
REMARK 500 O TRP G 483 CB LEU G 487 1.82
REMARK 500 O TRP A 483 CB LEU A 487 1.82
REMARK 500 O TRP I 483 CB LEU I 487 1.82
REMARK 500 O TRP K 483 CB LEU K 487 1.82
REMARK 500 O TRP M 483 CB LEU M 487 1.82
REMARK 500 OD2 ASP S 27 CB ARG V 13 1.93
REMARK 500 OD1 ASP G 209 CE LYS O 62 1.94
REMARK 500 CZ TYR I 862 CB HIS I 881 1.95
REMARK 500 O ASP A 1146 CG2 VAL A 1180 1.95
REMARK 500 O ASP C 1146 CG2 VAL C 1180 1.95
REMARK 500 CZ TYR E 862 CB HIS E 881 1.96
REMARK 500 CZ TYR K 862 CB HIS K 881 1.96
REMARK 500 CZ TYR C 862 CB HIS C 881 1.96
REMARK 500 CZ TYR M 862 CB HIS M 881 1.96
REMARK 500 CZ TYR G 862 CB HIS G 881 1.96
REMARK 500 CZ TYR A 862 CB HIS A 881 1.96
REMARK 500 O ILE G 510 OG1 THR G 514 1.96
REMARK 500 O ILE A 510 OG1 THR A 514 1.96
REMARK 500 O ILE K 510 OG1 THR K 514 1.96
REMARK 500 O ILE I 510 OG1 THR I 514 1.96
REMARK 500 O ILE E 510 OG1 THR E 514 1.96
REMARK 500 O ILE C 510 OG1 THR C 514 1.96
REMARK 500 O ILE M 510 OG1 THR M 514 1.96
REMARK 500 OH TYR C 845 O VAL C 888 1.97
REMARK 500 OH TYR A 845 O VAL A 888 1.97
REMARK 500 OH TYR E 845 O VAL E 888 1.97
REMARK 500 OH TYR K 845 O VAL K 888 1.97
REMARK 500 OH TYR I 845 O VAL I 888 1.97
REMARK 500 OH TYR M 845 O VAL M 888 1.97
REMARK 500 OH TYR G 845 O VAL G 888 1.97
REMARK 500 OD2 ASP Q 32 OG SER Q 70 1.97
REMARK 500 O THR C 573 CB TYR C 577 1.99
REMARK 500 O THR G 573 CB TYR G 577 1.99
REMARK 500 O THR E 573 CB TYR E 577 1.99
REMARK 500 O THR I 573 CB TYR I 577 1.99
REMARK 500 O THR M 573 CB TYR M 577 1.99
REMARK 500 O THR K 573 CB TYR K 577 1.99
REMARK 500 O THR A 573 CB TYR A 577 1.99
REMARK 500 O ASP M 1146 CG2 VAL M 1180 1.99
REMARK 500 O PRO M 559 N PRO M 561 2.00
REMARK 500 O PRO C 559 N PRO C 561 2.00
REMARK 500 O PRO G 559 N PRO G 561 2.00
REMARK 500 O PRO I 559 N PRO I 561 2.00
REMARK 500 O PRO A 559 N PRO A 561 2.00
REMARK 500 O PRO K 559 N PRO K 561 2.00
REMARK 500 O PRO E 559 N PRO E 561 2.00
REMARK 500 O LEU C 639 CG2 ILE C 653 2.01
REMARK 500 O LEU I 639 CG2 ILE I 653 2.01
REMARK 500
REMARK 500 THIS ENTRY HAS 209 CLOSE CONTACTS
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 TRP K1179 C VAL K1180 N -0.146
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 PRO A 147 C - N - CD ANGL. DEV. = -14.1 DEGREES
REMARK 500 PRO A 281 C - N - CD ANGL. DEV. = -17.4 DEGREES
REMARK 500 PRO A 561 C - N - CD ANGL. DEV. = -21.9 DEGREES
REMARK 500 PRO C 147 C - N - CD ANGL. DEV. = -13.9 DEGREES
REMARK 500 PRO C 281 C - N - CD ANGL. DEV. = -17.4 DEGREES
REMARK 500 PRO C 561 C - N - CD ANGL. DEV. = -21.9 DEGREES
REMARK 500 PRO E 147 C - N - CD ANGL. DEV. = -14.0 DEGREES
REMARK 500 PRO E 281 C - N - CD ANGL. DEV. = -17.3 DEGREES
REMARK 500 PRO E 561 C - N - CD ANGL. DEV. = -21.9 DEGREES
REMARK 500 PRO G 147 C - N - CD ANGL. DEV. = -14.1 DEGREES
REMARK 500 PRO G 281 C - N - CD ANGL. DEV. = -17.3 DEGREES
REMARK 500 PRO G 561 C - N - CD ANGL. DEV. = -21.8 DEGREES
REMARK 500 PRO I 147 C - N - CD ANGL. DEV. = -14.1 DEGREES
REMARK 500 PRO I 281 C - N - CD ANGL. DEV. = -17.4 DEGREES
REMARK 500 PRO I 561 C - N - CD ANGL. DEV. = -21.8 DEGREES
REMARK 500 PRO K 147 C - N - CD ANGL. DEV. = -14.1 DEGREES
REMARK 500 PRO K 281 C - N - CD ANGL. DEV. = -17.4 DEGREES
REMARK 500 PRO K 561 C - N - CD ANGL. DEV. = -21.9 DEGREES
REMARK 500 PRO M 147 C - N - CD ANGL. DEV. = -14.1 DEGREES
REMARK 500 PRO M 281 C - N - CD ANGL. DEV. = -17.3 DEGREES
REMARK 500 PRO M 561 C - N - CD ANGL. DEV. = -22.0 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 THR A 128 151.49 -40.78
REMARK 500 GLU A 146 141.51 66.57
REMARK 500 PRO A 147 179.45 -33.26
REMARK 500 GLU A 210 7.47 82.27
REMARK 500 ASP A 244 -127.44 60.93
REMARK 500 VAL A 245 120.64 98.89
REMARK 500 SER A 285 -69.52 -137.59
REMARK 500 LEU A 286 -178.21 80.00
REMARK 500 LYS A 348 4.13 87.14
REMARK 500 LEU A 424 106.35 -171.69
REMARK 500 TYR A 467 -127.00 -113.41
REMARK 500 LYS A 495 6.04 81.34
REMARK 500 LEU A 503 -72.16 -103.48
REMARK 500 LEU A 533 -111.99 -97.13
REMARK 500 ARG A 557 -97.18 -16.98
REMARK 500 GLN A 558 -72.56 -160.34
REMARK 500 PRO A 559 60.36 -50.33
REMARK 500 PHE A 560 63.67 -42.92
REMARK 500 PRO A 561 132.25 -20.20
REMARK 500 ASN A 562 87.51 -46.47
REMARK 500 LEU A 568 61.95 -63.62
REMARK 500 GLU A 572 -94.76 72.91
REMARK 500 THR A 573 -65.73 -175.14
REMARK 500 SER A 574 169.11 46.10
REMARK 500 MET A 592 -8.19 89.53
REMARK 500 THR A 604 110.33 76.21
REMARK 500 CYS A 633 -154.15 -98.95
REMARK 500 LYS A 637 -1.67 97.20
REMARK 500 GLU A 645 -93.53 -42.10
REMARK 500 ASP A 658 -176.92 80.46
REMARK 500 LYS A 679 26.40 91.98
REMARK 500 MET A 687 -68.11 -108.97
REMARK 500 VAL A 692 -71.95 -122.25
REMARK 500 GLU A 697 -27.28 -165.08
REMARK 500 HIS A 712 -76.75 -80.08
REMARK 500 CYS A 723 -28.27 81.17
REMARK 500 ASN A 737 113.93 -168.24
REMARK 500 ARG A 778 -55.48 -124.63
REMARK 500 SER A 780 92.68 -164.75
REMARK 500 LEU A 788 102.67 -163.82
REMARK 500 GLU A 795 -129.02 -72.45
REMARK 500 LYS A 802 -84.20 -109.17
REMARK 500 CYS A 804 69.30 -105.10
REMARK 500 LYS A 818 -102.91 52.89
REMARK 500 LEU A 832 -78.24 -129.31
REMARK 500 GLU A 834 91.57 -168.00
REMARK 500 HIS A 839 -138.46 49.68
REMARK 500 SER A 841 -122.68 -174.38
REMARK 500 ASP A 847 107.87 -160.89
REMARK 500 ASN A 852 12.45 53.06
REMARK 500
REMARK 500 THIS ENTRY HAS 720 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 M RES CSSEQI RMS TYPE
REMARK 500 ARG T 52 0.18 SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG A1302 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER A 161 OG
REMARK 620 2 DTP A1301 O3G 136.1
REMARK 620 3 DTP A1301 O2B 74.7 69.6
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 HEM B 201 FE
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS B 18 NE2
REMARK 620 2 HEM B 201 NA 107.7
REMARK 620 3 HEM B 201 NB 112.2 88.0
REMARK 620 4 HEM B 201 NC 73.0 173.7 86.0
REMARK 620 5 HEM B 201 ND 68.1 93.7 178.1 92.3
REMARK 620 6 MET B 80 SD 149.0 88.5 94.1 93.8 85.0
REMARK 620 N 1 2 3 4 5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG C1302 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER C 161 OG
REMARK 620 2 DTP C1301 O3G 136.2
REMARK 620 3 DTP C1301 O2B 74.8 69.7
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 HEM D 201 FE
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS D 18 NE2
REMARK 620 2 HEM D 201 NA 107.6
REMARK 620 3 HEM D 201 NB 112.2 88.0
REMARK 620 4 HEM D 201 NC 73.1 173.7 86.0
REMARK 620 5 HEM D 201 ND 68.1 93.7 178.1 92.3
REMARK 620 6 MET D 80 SD 149.1 88.5 94.1 93.8 85.0
REMARK 620 N 1 2 3 4 5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG E1302 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER E 161 OG
REMARK 620 2 DTP E1301 O3G 136.2
REMARK 620 3 DTP E1301 O2B 74.8 69.7
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 HEM F 201 FE
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS F 18 NE2
REMARK 620 2 HEM F 201 NA 107.7
REMARK 620 3 HEM F 201 NB 112.2 88.0
REMARK 620 4 HEM F 201 NC 73.0 173.6 85.9
REMARK 620 5 HEM F 201 ND 68.1 93.8 178.0 92.3
REMARK 620 6 MET F 80 SD 149.0 88.5 94.2 93.8 85.0
REMARK 620 N 1 2 3 4 5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG G1302 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER G 161 OG
REMARK 620 2 DTP G1301 O3G 136.2
REMARK 620 3 DTP G1301 O2B 74.8 69.7
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 HEM H 201 FE
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS H 18 NE2
REMARK 620 2 HEM H 201 NA 107.7
REMARK 620 3 HEM H 201 NB 112.3 87.9
REMARK 620 4 HEM H 201 NC 73.1 173.6 86.0
REMARK 620 5 HEM H 201 ND 68.1 93.8 178.1 92.3
REMARK 620 6 MET H 80 SD 149.0 88.5 94.1 93.8 85.0
REMARK 620 N 1 2 3 4 5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG I1302 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER I 161 OG
REMARK 620 2 DTP I1301 O3G 136.2
REMARK 620 3 DTP I1301 O2B 74.8 69.7
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 HEM J 201 FE
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS J 18 NE2
REMARK 620 2 HEM J 201 NA 107.6
REMARK 620 3 HEM J 201 NB 112.3 87.9
REMARK 620 4 HEM J 201 NC 73.1 173.6 86.0
REMARK 620 5 HEM J 201 ND 68.1 93.7 178.1 92.4
REMARK 620 6 MET J 80 SD 149.1 88.5 94.1 93.8 85.0
REMARK 620 N 1 2 3 4 5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG K1302 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER K 161 OG
REMARK 620 2 DTP K1301 O3G 136.2
REMARK 620 3 DTP K1301 O2B 74.7 69.7
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 HEM L 201 FE
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS L 18 NE2
REMARK 620 2 HEM L 201 NA 107.6
REMARK 620 3 HEM L 201 NB 112.2 87.9
REMARK 620 4 HEM L 201 NC 73.1 173.6 86.0
REMARK 620 5 HEM L 201 ND 68.2 93.8 178.1 92.4
REMARK 620 6 MET L 80 SD 149.2 88.4 94.1 93.8 85.0
REMARK 620 N 1 2 3 4 5
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG M1302 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 SER M 161 OG
REMARK 620 2 DTP M1301 O3G 136.2
REMARK 620 3 DTP M1301 O2B 74.8 69.7
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 HEM N 201 FE
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 HIS N 18 NE2
REMARK 620 2 HEM N 201 NA 107.6
REMARK 620 3 HEM N 201 NB 112.2 87.9
REMARK 620 4 HEM N 201 NC 73.2 173.7 86.0
REMARK 620 5 HEM N 201 ND 68.1 93.8 178.1 92.3
REMARK 620 6 MET N 80 SD 149.1 88.4 94.2 93.8 85.0
REMARK 620 N 1 2 3 4 5
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP A 1301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG A 1302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM B 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP C 1301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG C 1302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM D 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP E 1301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG E 1302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM F 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP G 1301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG G 1302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM H 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP I 1301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG I 1302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM J 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP K 1301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG K 1302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM L 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP M 1301
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG M 1302
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM N 201
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-6690 RELATED DB: EMDB
REMARK 900 APAF-1-CASPASE-9 HOLOENZYME
DBREF 5WVE A 1 1248 UNP O14727 APAF_HUMAN 1 1248
DBREF 5WVE B 0 104 UNP P00004 CYC_HORSE 1 105
DBREF 5WVE C 1 1248 UNP O14727 APAF_HUMAN 1 1248
DBREF 5WVE D 0 104 UNP P00004 CYC_HORSE 1 105
DBREF 5WVE E 1 1248 UNP O14727 APAF_HUMAN 1 1248
DBREF 5WVE F 0 104 UNP P00004 CYC_HORSE 1 105
DBREF 5WVE G 1 1248 UNP O14727 APAF_HUMAN 1 1248
DBREF 5WVE H 0 104 UNP P00004 CYC_HORSE 1 105
DBREF 5WVE I 1 1248 UNP O14727 APAF_HUMAN 1 1248
DBREF 5WVE J 0 104 UNP P00004 CYC_HORSE 1 105
DBREF 5WVE K 1 1248 UNP O14727 APAF_HUMAN 1 1248
DBREF 5WVE L 0 104 UNP P00004 CYC_HORSE 1 105
DBREF 5WVE M 1 1248 UNP O14727 APAF_HUMAN 1 1248
DBREF 5WVE N 0 104 UNP P00004 CYC_HORSE 1 105
DBREF 5WVE O 1 102 UNP O14727 APAF_HUMAN 1 102
DBREF 5WVE P 1 102 UNP O14727 APAF_HUMAN 1 102
DBREF 5WVE Q 1 102 UNP O14727 APAF_HUMAN 1 102
DBREF 5WVE R 1 102 UNP O14727 APAF_HUMAN 1 102
DBREF 5WVE S 1 100 UNP A8K7U6 A8K7U6_HUMAN 1 100
DBREF 5WVE T 1 100 UNP A8K7U6 A8K7U6_HUMAN 1 100
DBREF 5WVE U 1 100 UNP A8K7U6 A8K7U6_HUMAN 1 100
DBREF 5WVE V 1 100 UNP A8K7U6 A8K7U6_HUMAN 1 100
DBREF 5WVE W 1 102 UNP O14727 APAF_HUMAN 1 102
DBREF 5WVE X 1 102 UNP O14727 APAF_HUMAN 1 102
DBREF 5WVE Y 1 100 UNP A8K7U6 A8K7U6_HUMAN 1 100
SEQRES 1 A 1248 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 A 1248 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 A 1248 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 A 1248 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 A 1248 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 A 1248 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 A 1248 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 A 1248 PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER
SEQRES 9 A 1248 GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY
SEQRES 10 A 1248 GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS
SEQRES 11 A 1248 LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU
SEQRES 12 A 1248 LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA
SEQRES 13 A 1248 GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG
SEQRES 14 A 1248 ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL
SEQRES 15 A 1248 HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU
SEQRES 16 A 1248 LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN
SEQRES 17 A 1248 ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU
SEQRES 18 A 1248 GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS
SEQRES 19 A 1248 HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP
SEQRES 20 A 1248 SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE
SEQRES 21 A 1248 LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL
SEQRES 22 A 1248 MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU
SEQRES 23 A 1248 GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL
SEQRES 24 A 1248 ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER
SEQRES 25 A 1248 ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER
SEQRES 26 A 1248 LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP
SEQRES 27 A 1248 GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS
SEQRES 28 A 1248 ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU
SEQRES 29 A 1248 ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU
SEQRES 30 A 1248 ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN
SEQRES 31 A 1248 LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU
SEQRES 32 A 1248 TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN
SEQRES 33 A 1248 GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN
SEQRES 34 A 1248 GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL
SEQRES 35 A 1248 ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP
SEQRES 36 A 1248 LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS
SEQRES 37 A 1248 GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET
SEQRES 38 A 1248 TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA
SEQRES 39 A 1248 LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU
SEQRES 40 A 1248 ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA
SEQRES 41 A 1248 HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU
SEQRES 42 A 1248 ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU
SEQRES 43 A 1248 PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO
SEQRES 44 A 1248 PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU
SEQRES 45 A 1248 THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS
SEQRES 46 A 1248 GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE
SEQRES 47 A 1248 ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL
SEQRES 48 A 1248 ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER
SEQRES 49 A 1248 GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS
SEQRES 50 A 1248 THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU
SEQRES 51 A 1248 LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS
SEQRES 52 A 1248 ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER
SEQRES 53 A 1248 VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY
SEQRES 54 A 1248 GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL
SEQRES 55 A 1248 ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU
SEQRES 56 A 1248 LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP
SEQRES 57 A 1248 ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY
SEQRES 58 A 1248 HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP
SEQRES 59 A 1248 ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU
SEQRES 60 A 1248 LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER
SEQRES 61 A 1248 ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO
SEQRES 62 A 1248 GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP
SEQRES 63 A 1248 SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN
SEQRES 64 A 1248 LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU
SEQRES 65 A 1248 GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR
SEQRES 66 A 1248 CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA
SEQRES 67 A 1248 LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER
SEQRES 68 A 1248 ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP
SEQRES 69 A 1248 VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE
SEQRES 70 A 1248 LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU
SEQRES 71 A 1248 THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS
SEQRES 72 A 1248 GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET
SEQRES 73 A 1248 VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE
SEQRES 74 A 1248 ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA
SEQRES 75 A 1248 GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR
SEQRES 76 A 1248 ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU
SEQRES 77 A 1248 GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN
SEQRES 78 A 1248 HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP
SEQRES 79 A 1248 GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE
SEQRES 80 A 1248 GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU
SEQRES 81 A 1248 ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU
SEQRES 82 A 1248 LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR
SEQRES 83 A 1248 VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS
SEQRES 84 A 1248 ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP
SEQRES 85 A 1248 ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA
SEQRES 86 A 1248 ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU
SEQRES 87 A 1248 PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG
SEQRES 88 A 1248 CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR
SEQRES 89 A 1248 GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER
SEQRES 90 A 1248 ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU
SEQRES 91 A 1248 GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU
SEQRES 92 A 1248 CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY
SEQRES 93 A 1248 GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER
SEQRES 94 A 1248 SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS
SEQRES 95 A 1248 ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL
SEQRES 96 A 1248 ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU
SEQRES 1 B 105 MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN
SEQRES 2 B 105 LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS
SEQRES 3 B 105 HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG
SEQRES 4 B 105 LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA
SEQRES 5 B 105 ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU
SEQRES 6 B 105 MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY
SEQRES 7 B 105 THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU
SEQRES 8 B 105 ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN
SEQRES 9 B 105 GLU
SEQRES 1 C 1248 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 C 1248 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 C 1248 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 C 1248 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 C 1248 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 C 1248 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 C 1248 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 C 1248 PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER
SEQRES 9 C 1248 GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY
SEQRES 10 C 1248 GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS
SEQRES 11 C 1248 LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU
SEQRES 12 C 1248 LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA
SEQRES 13 C 1248 GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG
SEQRES 14 C 1248 ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL
SEQRES 15 C 1248 HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU
SEQRES 16 C 1248 LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN
SEQRES 17 C 1248 ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU
SEQRES 18 C 1248 GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS
SEQRES 19 C 1248 HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP
SEQRES 20 C 1248 SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE
SEQRES 21 C 1248 LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL
SEQRES 22 C 1248 MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU
SEQRES 23 C 1248 GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL
SEQRES 24 C 1248 ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER
SEQRES 25 C 1248 ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER
SEQRES 26 C 1248 LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP
SEQRES 27 C 1248 GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS
SEQRES 28 C 1248 ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU
SEQRES 29 C 1248 ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU
SEQRES 30 C 1248 ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN
SEQRES 31 C 1248 LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU
SEQRES 32 C 1248 TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN
SEQRES 33 C 1248 GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN
SEQRES 34 C 1248 GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL
SEQRES 35 C 1248 ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP
SEQRES 36 C 1248 LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS
SEQRES 37 C 1248 GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET
SEQRES 38 C 1248 TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA
SEQRES 39 C 1248 LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU
SEQRES 40 C 1248 ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA
SEQRES 41 C 1248 HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU
SEQRES 42 C 1248 ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU
SEQRES 43 C 1248 PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO
SEQRES 44 C 1248 PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU
SEQRES 45 C 1248 THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS
SEQRES 46 C 1248 GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE
SEQRES 47 C 1248 ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL
SEQRES 48 C 1248 ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER
SEQRES 49 C 1248 GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS
SEQRES 50 C 1248 THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU
SEQRES 51 C 1248 LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS
SEQRES 52 C 1248 ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER
SEQRES 53 C 1248 VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY
SEQRES 54 C 1248 GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL
SEQRES 55 C 1248 ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU
SEQRES 56 C 1248 LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP
SEQRES 57 C 1248 ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY
SEQRES 58 C 1248 HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP
SEQRES 59 C 1248 ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU
SEQRES 60 C 1248 LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER
SEQRES 61 C 1248 ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO
SEQRES 62 C 1248 GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP
SEQRES 63 C 1248 SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN
SEQRES 64 C 1248 LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU
SEQRES 65 C 1248 GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR
SEQRES 66 C 1248 CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA
SEQRES 67 C 1248 LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER
SEQRES 68 C 1248 ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP
SEQRES 69 C 1248 VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE
SEQRES 70 C 1248 LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU
SEQRES 71 C 1248 THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS
SEQRES 72 C 1248 GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET
SEQRES 73 C 1248 VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE
SEQRES 74 C 1248 ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA
SEQRES 75 C 1248 GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR
SEQRES 76 C 1248 ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU
SEQRES 77 C 1248 GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN
SEQRES 78 C 1248 HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP
SEQRES 79 C 1248 GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE
SEQRES 80 C 1248 GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU
SEQRES 81 C 1248 ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU
SEQRES 82 C 1248 LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR
SEQRES 83 C 1248 VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS
SEQRES 84 C 1248 ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP
SEQRES 85 C 1248 ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA
SEQRES 86 C 1248 ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU
SEQRES 87 C 1248 PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG
SEQRES 88 C 1248 CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR
SEQRES 89 C 1248 GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER
SEQRES 90 C 1248 ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU
SEQRES 91 C 1248 GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU
SEQRES 92 C 1248 CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY
SEQRES 93 C 1248 GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER
SEQRES 94 C 1248 SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS
SEQRES 95 C 1248 ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL
SEQRES 96 C 1248 ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU
SEQRES 1 D 105 MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN
SEQRES 2 D 105 LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS
SEQRES 3 D 105 HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG
SEQRES 4 D 105 LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA
SEQRES 5 D 105 ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU
SEQRES 6 D 105 MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY
SEQRES 7 D 105 THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU
SEQRES 8 D 105 ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN
SEQRES 9 D 105 GLU
SEQRES 1 E 1248 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 E 1248 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 E 1248 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 E 1248 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 E 1248 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 E 1248 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 E 1248 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 E 1248 PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER
SEQRES 9 E 1248 GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY
SEQRES 10 E 1248 GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS
SEQRES 11 E 1248 LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU
SEQRES 12 E 1248 LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA
SEQRES 13 E 1248 GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG
SEQRES 14 E 1248 ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL
SEQRES 15 E 1248 HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU
SEQRES 16 E 1248 LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN
SEQRES 17 E 1248 ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU
SEQRES 18 E 1248 GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS
SEQRES 19 E 1248 HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP
SEQRES 20 E 1248 SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE
SEQRES 21 E 1248 LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL
SEQRES 22 E 1248 MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU
SEQRES 23 E 1248 GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL
SEQRES 24 E 1248 ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER
SEQRES 25 E 1248 ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER
SEQRES 26 E 1248 LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP
SEQRES 27 E 1248 GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS
SEQRES 28 E 1248 ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU
SEQRES 29 E 1248 ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU
SEQRES 30 E 1248 ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN
SEQRES 31 E 1248 LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU
SEQRES 32 E 1248 TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN
SEQRES 33 E 1248 GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN
SEQRES 34 E 1248 GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL
SEQRES 35 E 1248 ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP
SEQRES 36 E 1248 LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS
SEQRES 37 E 1248 GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET
SEQRES 38 E 1248 TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA
SEQRES 39 E 1248 LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU
SEQRES 40 E 1248 ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA
SEQRES 41 E 1248 HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU
SEQRES 42 E 1248 ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU
SEQRES 43 E 1248 PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO
SEQRES 44 E 1248 PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU
SEQRES 45 E 1248 THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS
SEQRES 46 E 1248 GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE
SEQRES 47 E 1248 ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL
SEQRES 48 E 1248 ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER
SEQRES 49 E 1248 GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS
SEQRES 50 E 1248 THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU
SEQRES 51 E 1248 LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS
SEQRES 52 E 1248 ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER
SEQRES 53 E 1248 VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY
SEQRES 54 E 1248 GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL
SEQRES 55 E 1248 ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU
SEQRES 56 E 1248 LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP
SEQRES 57 E 1248 ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY
SEQRES 58 E 1248 HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP
SEQRES 59 E 1248 ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU
SEQRES 60 E 1248 LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER
SEQRES 61 E 1248 ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO
SEQRES 62 E 1248 GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP
SEQRES 63 E 1248 SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN
SEQRES 64 E 1248 LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU
SEQRES 65 E 1248 GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR
SEQRES 66 E 1248 CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA
SEQRES 67 E 1248 LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER
SEQRES 68 E 1248 ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP
SEQRES 69 E 1248 VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE
SEQRES 70 E 1248 LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU
SEQRES 71 E 1248 THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS
SEQRES 72 E 1248 GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET
SEQRES 73 E 1248 VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE
SEQRES 74 E 1248 ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA
SEQRES 75 E 1248 GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR
SEQRES 76 E 1248 ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU
SEQRES 77 E 1248 GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN
SEQRES 78 E 1248 HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP
SEQRES 79 E 1248 GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE
SEQRES 80 E 1248 GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU
SEQRES 81 E 1248 ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU
SEQRES 82 E 1248 LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR
SEQRES 83 E 1248 VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS
SEQRES 84 E 1248 ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP
SEQRES 85 E 1248 ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA
SEQRES 86 E 1248 ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU
SEQRES 87 E 1248 PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG
SEQRES 88 E 1248 CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR
SEQRES 89 E 1248 GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER
SEQRES 90 E 1248 ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU
SEQRES 91 E 1248 GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU
SEQRES 92 E 1248 CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY
SEQRES 93 E 1248 GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER
SEQRES 94 E 1248 SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS
SEQRES 95 E 1248 ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL
SEQRES 96 E 1248 ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU
SEQRES 1 F 105 MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN
SEQRES 2 F 105 LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS
SEQRES 3 F 105 HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG
SEQRES 4 F 105 LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA
SEQRES 5 F 105 ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU
SEQRES 6 F 105 MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY
SEQRES 7 F 105 THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU
SEQRES 8 F 105 ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN
SEQRES 9 F 105 GLU
SEQRES 1 G 1248 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 G 1248 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 G 1248 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 G 1248 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 G 1248 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 G 1248 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 G 1248 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 G 1248 PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER
SEQRES 9 G 1248 GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY
SEQRES 10 G 1248 GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS
SEQRES 11 G 1248 LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU
SEQRES 12 G 1248 LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA
SEQRES 13 G 1248 GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG
SEQRES 14 G 1248 ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL
SEQRES 15 G 1248 HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU
SEQRES 16 G 1248 LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN
SEQRES 17 G 1248 ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU
SEQRES 18 G 1248 GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS
SEQRES 19 G 1248 HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP
SEQRES 20 G 1248 SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE
SEQRES 21 G 1248 LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL
SEQRES 22 G 1248 MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU
SEQRES 23 G 1248 GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL
SEQRES 24 G 1248 ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER
SEQRES 25 G 1248 ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER
SEQRES 26 G 1248 LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP
SEQRES 27 G 1248 GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS
SEQRES 28 G 1248 ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU
SEQRES 29 G 1248 ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU
SEQRES 30 G 1248 ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN
SEQRES 31 G 1248 LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU
SEQRES 32 G 1248 TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN
SEQRES 33 G 1248 GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN
SEQRES 34 G 1248 GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL
SEQRES 35 G 1248 ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP
SEQRES 36 G 1248 LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS
SEQRES 37 G 1248 GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET
SEQRES 38 G 1248 TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA
SEQRES 39 G 1248 LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU
SEQRES 40 G 1248 ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA
SEQRES 41 G 1248 HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU
SEQRES 42 G 1248 ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU
SEQRES 43 G 1248 PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO
SEQRES 44 G 1248 PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU
SEQRES 45 G 1248 THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS
SEQRES 46 G 1248 GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE
SEQRES 47 G 1248 ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL
SEQRES 48 G 1248 ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER
SEQRES 49 G 1248 GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS
SEQRES 50 G 1248 THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU
SEQRES 51 G 1248 LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS
SEQRES 52 G 1248 ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER
SEQRES 53 G 1248 VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY
SEQRES 54 G 1248 GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL
SEQRES 55 G 1248 ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU
SEQRES 56 G 1248 LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP
SEQRES 57 G 1248 ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY
SEQRES 58 G 1248 HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP
SEQRES 59 G 1248 ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU
SEQRES 60 G 1248 LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER
SEQRES 61 G 1248 ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO
SEQRES 62 G 1248 GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP
SEQRES 63 G 1248 SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN
SEQRES 64 G 1248 LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU
SEQRES 65 G 1248 GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR
SEQRES 66 G 1248 CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA
SEQRES 67 G 1248 LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER
SEQRES 68 G 1248 ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP
SEQRES 69 G 1248 VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE
SEQRES 70 G 1248 LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU
SEQRES 71 G 1248 THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS
SEQRES 72 G 1248 GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET
SEQRES 73 G 1248 VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE
SEQRES 74 G 1248 ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA
SEQRES 75 G 1248 GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR
SEQRES 76 G 1248 ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU
SEQRES 77 G 1248 GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN
SEQRES 78 G 1248 HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP
SEQRES 79 G 1248 GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE
SEQRES 80 G 1248 GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU
SEQRES 81 G 1248 ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU
SEQRES 82 G 1248 LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR
SEQRES 83 G 1248 VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS
SEQRES 84 G 1248 ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP
SEQRES 85 G 1248 ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA
SEQRES 86 G 1248 ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU
SEQRES 87 G 1248 PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG
SEQRES 88 G 1248 CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR
SEQRES 89 G 1248 GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER
SEQRES 90 G 1248 ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU
SEQRES 91 G 1248 GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU
SEQRES 92 G 1248 CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY
SEQRES 93 G 1248 GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER
SEQRES 94 G 1248 SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS
SEQRES 95 G 1248 ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL
SEQRES 96 G 1248 ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU
SEQRES 1 H 105 MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN
SEQRES 2 H 105 LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS
SEQRES 3 H 105 HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG
SEQRES 4 H 105 LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA
SEQRES 5 H 105 ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU
SEQRES 6 H 105 MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY
SEQRES 7 H 105 THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU
SEQRES 8 H 105 ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN
SEQRES 9 H 105 GLU
SEQRES 1 I 1248 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 I 1248 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 I 1248 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 I 1248 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 I 1248 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 I 1248 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 I 1248 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 I 1248 PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER
SEQRES 9 I 1248 GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY
SEQRES 10 I 1248 GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS
SEQRES 11 I 1248 LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU
SEQRES 12 I 1248 LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA
SEQRES 13 I 1248 GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG
SEQRES 14 I 1248 ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL
SEQRES 15 I 1248 HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU
SEQRES 16 I 1248 LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN
SEQRES 17 I 1248 ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU
SEQRES 18 I 1248 GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS
SEQRES 19 I 1248 HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP
SEQRES 20 I 1248 SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE
SEQRES 21 I 1248 LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL
SEQRES 22 I 1248 MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU
SEQRES 23 I 1248 GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL
SEQRES 24 I 1248 ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER
SEQRES 25 I 1248 ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER
SEQRES 26 I 1248 LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP
SEQRES 27 I 1248 GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS
SEQRES 28 I 1248 ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU
SEQRES 29 I 1248 ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU
SEQRES 30 I 1248 ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN
SEQRES 31 I 1248 LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU
SEQRES 32 I 1248 TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN
SEQRES 33 I 1248 GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN
SEQRES 34 I 1248 GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL
SEQRES 35 I 1248 ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP
SEQRES 36 I 1248 LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS
SEQRES 37 I 1248 GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET
SEQRES 38 I 1248 TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA
SEQRES 39 I 1248 LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU
SEQRES 40 I 1248 ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA
SEQRES 41 I 1248 HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU
SEQRES 42 I 1248 ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU
SEQRES 43 I 1248 PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO
SEQRES 44 I 1248 PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU
SEQRES 45 I 1248 THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS
SEQRES 46 I 1248 GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE
SEQRES 47 I 1248 ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL
SEQRES 48 I 1248 ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER
SEQRES 49 I 1248 GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS
SEQRES 50 I 1248 THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU
SEQRES 51 I 1248 LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS
SEQRES 52 I 1248 ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER
SEQRES 53 I 1248 VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY
SEQRES 54 I 1248 GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL
SEQRES 55 I 1248 ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU
SEQRES 56 I 1248 LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP
SEQRES 57 I 1248 ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY
SEQRES 58 I 1248 HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP
SEQRES 59 I 1248 ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU
SEQRES 60 I 1248 LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER
SEQRES 61 I 1248 ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO
SEQRES 62 I 1248 GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP
SEQRES 63 I 1248 SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN
SEQRES 64 I 1248 LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU
SEQRES 65 I 1248 GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR
SEQRES 66 I 1248 CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA
SEQRES 67 I 1248 LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER
SEQRES 68 I 1248 ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP
SEQRES 69 I 1248 VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE
SEQRES 70 I 1248 LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU
SEQRES 71 I 1248 THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS
SEQRES 72 I 1248 GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET
SEQRES 73 I 1248 VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE
SEQRES 74 I 1248 ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA
SEQRES 75 I 1248 GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR
SEQRES 76 I 1248 ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU
SEQRES 77 I 1248 GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN
SEQRES 78 I 1248 HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP
SEQRES 79 I 1248 GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE
SEQRES 80 I 1248 GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU
SEQRES 81 I 1248 ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU
SEQRES 82 I 1248 LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR
SEQRES 83 I 1248 VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS
SEQRES 84 I 1248 ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP
SEQRES 85 I 1248 ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA
SEQRES 86 I 1248 ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU
SEQRES 87 I 1248 PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG
SEQRES 88 I 1248 CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR
SEQRES 89 I 1248 GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER
SEQRES 90 I 1248 ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU
SEQRES 91 I 1248 GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU
SEQRES 92 I 1248 CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY
SEQRES 93 I 1248 GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER
SEQRES 94 I 1248 SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS
SEQRES 95 I 1248 ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL
SEQRES 96 I 1248 ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU
SEQRES 1 J 105 MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN
SEQRES 2 J 105 LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS
SEQRES 3 J 105 HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG
SEQRES 4 J 105 LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA
SEQRES 5 J 105 ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU
SEQRES 6 J 105 MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY
SEQRES 7 J 105 THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU
SEQRES 8 J 105 ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN
SEQRES 9 J 105 GLU
SEQRES 1 K 1248 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 K 1248 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 K 1248 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 K 1248 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 K 1248 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 K 1248 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 K 1248 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 K 1248 PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER
SEQRES 9 K 1248 GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY
SEQRES 10 K 1248 GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS
SEQRES 11 K 1248 LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU
SEQRES 12 K 1248 LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA
SEQRES 13 K 1248 GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG
SEQRES 14 K 1248 ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL
SEQRES 15 K 1248 HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU
SEQRES 16 K 1248 LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN
SEQRES 17 K 1248 ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU
SEQRES 18 K 1248 GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS
SEQRES 19 K 1248 HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP
SEQRES 20 K 1248 SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE
SEQRES 21 K 1248 LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL
SEQRES 22 K 1248 MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU
SEQRES 23 K 1248 GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL
SEQRES 24 K 1248 ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER
SEQRES 25 K 1248 ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER
SEQRES 26 K 1248 LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP
SEQRES 27 K 1248 GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS
SEQRES 28 K 1248 ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU
SEQRES 29 K 1248 ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU
SEQRES 30 K 1248 ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN
SEQRES 31 K 1248 LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU
SEQRES 32 K 1248 TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN
SEQRES 33 K 1248 GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN
SEQRES 34 K 1248 GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL
SEQRES 35 K 1248 ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP
SEQRES 36 K 1248 LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS
SEQRES 37 K 1248 GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET
SEQRES 38 K 1248 TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA
SEQRES 39 K 1248 LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU
SEQRES 40 K 1248 ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA
SEQRES 41 K 1248 HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU
SEQRES 42 K 1248 ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU
SEQRES 43 K 1248 PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO
SEQRES 44 K 1248 PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU
SEQRES 45 K 1248 THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS
SEQRES 46 K 1248 GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE
SEQRES 47 K 1248 ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL
SEQRES 48 K 1248 ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER
SEQRES 49 K 1248 GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS
SEQRES 50 K 1248 THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU
SEQRES 51 K 1248 LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS
SEQRES 52 K 1248 ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER
SEQRES 53 K 1248 VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY
SEQRES 54 K 1248 GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL
SEQRES 55 K 1248 ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU
SEQRES 56 K 1248 LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP
SEQRES 57 K 1248 ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY
SEQRES 58 K 1248 HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP
SEQRES 59 K 1248 ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU
SEQRES 60 K 1248 LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER
SEQRES 61 K 1248 ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO
SEQRES 62 K 1248 GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP
SEQRES 63 K 1248 SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN
SEQRES 64 K 1248 LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU
SEQRES 65 K 1248 GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR
SEQRES 66 K 1248 CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA
SEQRES 67 K 1248 LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER
SEQRES 68 K 1248 ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP
SEQRES 69 K 1248 VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE
SEQRES 70 K 1248 LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU
SEQRES 71 K 1248 THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS
SEQRES 72 K 1248 GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET
SEQRES 73 K 1248 VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE
SEQRES 74 K 1248 ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA
SEQRES 75 K 1248 GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR
SEQRES 76 K 1248 ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU
SEQRES 77 K 1248 GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN
SEQRES 78 K 1248 HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP
SEQRES 79 K 1248 GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE
SEQRES 80 K 1248 GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU
SEQRES 81 K 1248 ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU
SEQRES 82 K 1248 LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR
SEQRES 83 K 1248 VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS
SEQRES 84 K 1248 ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP
SEQRES 85 K 1248 ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA
SEQRES 86 K 1248 ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU
SEQRES 87 K 1248 PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG
SEQRES 88 K 1248 CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR
SEQRES 89 K 1248 GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER
SEQRES 90 K 1248 ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU
SEQRES 91 K 1248 GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU
SEQRES 92 K 1248 CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY
SEQRES 93 K 1248 GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER
SEQRES 94 K 1248 SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS
SEQRES 95 K 1248 ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL
SEQRES 96 K 1248 ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU
SEQRES 1 L 105 MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN
SEQRES 2 L 105 LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS
SEQRES 3 L 105 HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG
SEQRES 4 L 105 LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA
SEQRES 5 L 105 ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU
SEQRES 6 L 105 MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY
SEQRES 7 L 105 THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU
SEQRES 8 L 105 ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN
SEQRES 9 L 105 GLU
SEQRES 1 M 1248 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 M 1248 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 M 1248 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 M 1248 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 M 1248 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 M 1248 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 M 1248 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 M 1248 PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER
SEQRES 9 M 1248 GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY
SEQRES 10 M 1248 GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS
SEQRES 11 M 1248 LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU
SEQRES 12 M 1248 LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA
SEQRES 13 M 1248 GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG
SEQRES 14 M 1248 ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL
SEQRES 15 M 1248 HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU
SEQRES 16 M 1248 LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN
SEQRES 17 M 1248 ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU
SEQRES 18 M 1248 GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS
SEQRES 19 M 1248 HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP
SEQRES 20 M 1248 SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE
SEQRES 21 M 1248 LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL
SEQRES 22 M 1248 MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU
SEQRES 23 M 1248 GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL
SEQRES 24 M 1248 ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER
SEQRES 25 M 1248 ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER
SEQRES 26 M 1248 LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP
SEQRES 27 M 1248 GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS
SEQRES 28 M 1248 ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU
SEQRES 29 M 1248 ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU
SEQRES 30 M 1248 ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN
SEQRES 31 M 1248 LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU
SEQRES 32 M 1248 TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN
SEQRES 33 M 1248 GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN
SEQRES 34 M 1248 GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL
SEQRES 35 M 1248 ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP
SEQRES 36 M 1248 LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS
SEQRES 37 M 1248 GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET
SEQRES 38 M 1248 TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA
SEQRES 39 M 1248 LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU
SEQRES 40 M 1248 ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA
SEQRES 41 M 1248 HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU
SEQRES 42 M 1248 ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU
SEQRES 43 M 1248 PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO
SEQRES 44 M 1248 PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU
SEQRES 45 M 1248 THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS
SEQRES 46 M 1248 GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE
SEQRES 47 M 1248 ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL
SEQRES 48 M 1248 ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER
SEQRES 49 M 1248 GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS
SEQRES 50 M 1248 THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU
SEQRES 51 M 1248 LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS
SEQRES 52 M 1248 ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER
SEQRES 53 M 1248 VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY
SEQRES 54 M 1248 GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL
SEQRES 55 M 1248 ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU
SEQRES 56 M 1248 LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP
SEQRES 57 M 1248 ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY
SEQRES 58 M 1248 HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP
SEQRES 59 M 1248 ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU
SEQRES 60 M 1248 LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER
SEQRES 61 M 1248 ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO
SEQRES 62 M 1248 GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP
SEQRES 63 M 1248 SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN
SEQRES 64 M 1248 LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU
SEQRES 65 M 1248 GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR
SEQRES 66 M 1248 CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA
SEQRES 67 M 1248 LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER
SEQRES 68 M 1248 ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP
SEQRES 69 M 1248 VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE
SEQRES 70 M 1248 LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU
SEQRES 71 M 1248 THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS
SEQRES 72 M 1248 GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET
SEQRES 73 M 1248 VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE
SEQRES 74 M 1248 ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA
SEQRES 75 M 1248 GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR
SEQRES 76 M 1248 ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU
SEQRES 77 M 1248 GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN
SEQRES 78 M 1248 HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP
SEQRES 79 M 1248 GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE
SEQRES 80 M 1248 GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU
SEQRES 81 M 1248 ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU
SEQRES 82 M 1248 LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR
SEQRES 83 M 1248 VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS
SEQRES 84 M 1248 ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP
SEQRES 85 M 1248 ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA
SEQRES 86 M 1248 ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU
SEQRES 87 M 1248 PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG
SEQRES 88 M 1248 CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR
SEQRES 89 M 1248 GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER
SEQRES 90 M 1248 ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU
SEQRES 91 M 1248 GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU
SEQRES 92 M 1248 CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY
SEQRES 93 M 1248 GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER
SEQRES 94 M 1248 SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS
SEQRES 95 M 1248 ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL
SEQRES 96 M 1248 ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU
SEQRES 1 N 105 MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN
SEQRES 2 N 105 LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS
SEQRES 3 N 105 HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG
SEQRES 4 N 105 LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA
SEQRES 5 N 105 ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU
SEQRES 6 N 105 MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY
SEQRES 7 N 105 THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU
SEQRES 8 N 105 ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN
SEQRES 9 N 105 GLU
SEQRES 1 O 102 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 O 102 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 O 102 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 O 102 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 O 102 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 O 102 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 O 102 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 O 102 PRO VAL VAL SER SER SER SER GLY LYS ASP SER
SEQRES 1 P 102 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 P 102 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 P 102 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 P 102 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 P 102 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 P 102 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 P 102 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 P 102 PRO VAL VAL SER SER SER SER GLY LYS ASP SER
SEQRES 1 Q 102 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 Q 102 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 Q 102 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 Q 102 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 Q 102 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 Q 102 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 Q 102 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 Q 102 PRO VAL VAL SER SER SER SER GLY LYS ASP SER
SEQRES 1 R 102 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 R 102 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 R 102 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 R 102 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 R 102 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 R 102 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 R 102 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 R 102 PRO VAL VAL SER SER SER SER GLY LYS ASP SER
SEQRES 1 S 100 MET ASP GLU ALA ASP ARG ARG LEU LEU ARG ARG CYS ARG
SEQRES 2 S 100 LEU ARG LEU VAL GLU GLU LEU GLN VAL ASP GLN LEU TRP
SEQRES 3 S 100 ASP VAL LEU LEU SER ARG GLU LEU PHE ARG PRO HIS MET
SEQRES 4 S 100 ILE GLU ASP ILE GLN ARG ALA GLY SER GLY SER ARG ARG
SEQRES 5 S 100 ASP GLN ALA ARG GLN LEU ILE ILE ASP LEU GLU THR ARG
SEQRES 6 S 100 GLY SER GLN ALA LEU PRO LEU PHE ILE SER CYS LEU GLU
SEQRES 7 S 100 ASP THR GLY GLN ASP MET LEU ALA SER PHE LEU ARG THR
SEQRES 8 S 100 ASN ARG GLN ALA ALA LYS LEU SER LYS
SEQRES 1 T 100 MET ASP GLU ALA ASP ARG ARG LEU LEU ARG ARG CYS ARG
SEQRES 2 T 100 LEU ARG LEU VAL GLU GLU LEU GLN VAL ASP GLN LEU TRP
SEQRES 3 T 100 ASP VAL LEU LEU SER ARG GLU LEU PHE ARG PRO HIS MET
SEQRES 4 T 100 ILE GLU ASP ILE GLN ARG ALA GLY SER GLY SER ARG ARG
SEQRES 5 T 100 ASP GLN ALA ARG GLN LEU ILE ILE ASP LEU GLU THR ARG
SEQRES 6 T 100 GLY SER GLN ALA LEU PRO LEU PHE ILE SER CYS LEU GLU
SEQRES 7 T 100 ASP THR GLY GLN ASP MET LEU ALA SER PHE LEU ARG THR
SEQRES 8 T 100 ASN ARG GLN ALA ALA LYS LEU SER LYS
SEQRES 1 U 100 MET ASP GLU ALA ASP ARG ARG LEU LEU ARG ARG CYS ARG
SEQRES 2 U 100 LEU ARG LEU VAL GLU GLU LEU GLN VAL ASP GLN LEU TRP
SEQRES 3 U 100 ASP VAL LEU LEU SER ARG GLU LEU PHE ARG PRO HIS MET
SEQRES 4 U 100 ILE GLU ASP ILE GLN ARG ALA GLY SER GLY SER ARG ARG
SEQRES 5 U 100 ASP GLN ALA ARG GLN LEU ILE ILE ASP LEU GLU THR ARG
SEQRES 6 U 100 GLY SER GLN ALA LEU PRO LEU PHE ILE SER CYS LEU GLU
SEQRES 7 U 100 ASP THR GLY GLN ASP MET LEU ALA SER PHE LEU ARG THR
SEQRES 8 U 100 ASN ARG GLN ALA ALA LYS LEU SER LYS
SEQRES 1 V 100 MET ASP GLU ALA ASP ARG ARG LEU LEU ARG ARG CYS ARG
SEQRES 2 V 100 LEU ARG LEU VAL GLU GLU LEU GLN VAL ASP GLN LEU TRP
SEQRES 3 V 100 ASP VAL LEU LEU SER ARG GLU LEU PHE ARG PRO HIS MET
SEQRES 4 V 100 ILE GLU ASP ILE GLN ARG ALA GLY SER GLY SER ARG ARG
SEQRES 5 V 100 ASP GLN ALA ARG GLN LEU ILE ILE ASP LEU GLU THR ARG
SEQRES 6 V 100 GLY SER GLN ALA LEU PRO LEU PHE ILE SER CYS LEU GLU
SEQRES 7 V 100 ASP THR GLY GLN ASP MET LEU ALA SER PHE LEU ARG THR
SEQRES 8 V 100 ASN ARG GLN ALA ALA LYS LEU SER LYS
SEQRES 1 W 102 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 W 102 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 W 102 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 W 102 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 W 102 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 W 102 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 W 102 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 W 102 PRO VAL VAL SER SER SER SER GLY LYS ASP SER
SEQRES 1 X 102 MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG
SEQRES 2 X 102 GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET
SEQRES 3 X 102 ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU
SEQRES 4 X 102 GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG
SEQRES 5 X 102 ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN
SEQRES 6 X 102 ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU
SEQRES 7 X 102 GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE
SEQRES 8 X 102 PRO VAL VAL SER SER SER SER GLY LYS ASP SER
SEQRES 1 Y 100 MET ASP GLU ALA ASP ARG ARG LEU LEU ARG ARG CYS ARG
SEQRES 2 Y 100 LEU ARG LEU VAL GLU GLU LEU GLN VAL ASP GLN LEU TRP
SEQRES 3 Y 100 ASP VAL LEU LEU SER ARG GLU LEU PHE ARG PRO HIS MET
SEQRES 4 Y 100 ILE GLU ASP ILE GLN ARG ALA GLY SER GLY SER ARG ARG
SEQRES 5 Y 100 ASP GLN ALA ARG GLN LEU ILE ILE ASP LEU GLU THR ARG
SEQRES 6 Y 100 GLY SER GLN ALA LEU PRO LEU PHE ILE SER CYS LEU GLU
SEQRES 7 Y 100 ASP THR GLY GLN ASP MET LEU ALA SER PHE LEU ARG THR
SEQRES 8 Y 100 ASN ARG GLN ALA ALA LYS LEU SER LYS
HET DTP A1301 30
HET MG A1302 1
HET HEM B 201 43
HET DTP C1301 30
HET MG C1302 1
HET HEM D 201 43
HET DTP E1301 30
HET MG E1302 1
HET HEM F 201 43
HET DTP G1301 30
HET MG G1302 1
HET HEM H 201 43
HET DTP I1301 30
HET MG I1302 1
HET HEM J 201 43
HET DTP K1301 30
HET MG K1302 1
HET HEM L 201 43
HET DTP M1301 30
HET MG M1302 1
HET HEM N 201 43
HETNAM DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE
HETNAM MG MAGNESIUM ION
HETNAM HEM PROTOPORPHYRIN IX CONTAINING FE
HETSYN HEM HEME
FORMUL 26 DTP 7(C10 H16 N5 O12 P3)
FORMUL 27 MG 7(MG 2+)
FORMUL 28 HEM 7(C34 H32 FE N4 O4)
HELIX 1 AA1 THR A 107 GLY A 118 1 12
HELIX 2 AA2 ARG A 129 LEU A 143 1 15
HELIX 3 AA3 GLY A 159 ASP A 170 1 12
HELIX 4 AA4 ASP A 170 PHE A 178 1 9
HELIX 5 AA5 ASP A 191 ASP A 207 1 17
HELIX 6 AA6 ASN A 219 ARG A 233 1 15
HELIX 7 AA7 ASP A 247 ASP A 255 1 9
HELIX 8 AA8 GLY A 287 ASN A 300 1 14
HELIX 9 AA9 PRO A 307 LYS A 318 1 12
HELIX 10 AB1 SER A 320 PHE A 334 1 15
HELIX 11 AB2 ARG A 337 LYS A 348 1 12
HELIX 12 AB3 ALA A 363 MET A 374 1 12
HELIX 13 AB4 ARG A 376 LEU A 386 1 11
HELIX 14 AB5 THR A 397 ASP A 405 1 9
HELIX 15 AB6 GLU A 407 LYS A 421 1 15
HELIX 16 AB7 HIS A 438 TYR A 467 1 30
HELIX 17 AB8 ASP A 479 LYS A 495 1 17
HELIX 18 AB9 MET A 496 MET A 504 1 9
HELIX 19 AC1 SER A 506 GLY A 518 1 13
HELIX 20 AC2 ALA A 520 LEU A 533 1 14
HELIX 21 AC3 ASP A 534 LEU A 550 1 17
HELIX 22 AC4 LEU A 550 LEU A 555 1 6
HELIX 23 AC5 ASN A 562 GLY A 567 1 6
HELIX 24 AC6 THR A 573 GLY A 591 1 19
HELIX 25 AC7 ASN A 599 ILE A 603 5 5
HELIX 26 AC8 PRO A 850 ASN A 852 5 3
HELIX 27 AC9 THR A 911 LYS A 916 1 6
HELIX 28 AD1 ASP B 2 CYS B 14 1 13
HELIX 29 AD2 THR B 49 LYS B 55 1 7
HELIX 30 AD3 LYS B 60 ASN B 70 1 11
HELIX 31 AD4 ASN B 70 ILE B 75 1 6
HELIX 32 AD5 LYS B 87 THR B 102 1 16
HELIX 33 AD6 THR C 107 GLY C 118 1 12
HELIX 34 AD7 ARG C 129 LEU C 143 1 15
HELIX 35 AD8 GLY C 159 ASP C 170 1 12
HELIX 36 AD9 ASP C 170 PHE C 178 1 9
HELIX 37 AE1 ASP C 191 ASP C 207 1 17
HELIX 38 AE2 ASN C 219 ARG C 233 1 15
HELIX 39 AE3 ASP C 247 ASP C 255 1 9
HELIX 40 AE4 GLY C 287 ASN C 300 1 14
HELIX 41 AE5 PRO C 307 LYS C 318 1 12
HELIX 42 AE6 SER C 320 PHE C 334 1 15
HELIX 43 AE7 ARG C 337 LYS C 348 1 12
HELIX 44 AE8 ALA C 363 MET C 374 1 12
HELIX 45 AE9 ARG C 376 LEU C 386 1 11
HELIX 46 AF1 THR C 397 ASP C 405 1 9
HELIX 47 AF2 GLU C 407 LYS C 421 1 15
HELIX 48 AF3 HIS C 438 TYR C 467 1 30
HELIX 49 AF4 ASP C 479 LYS C 495 1 17
HELIX 50 AF5 MET C 496 MET C 504 1 9
HELIX 51 AF6 SER C 506 GLY C 518 1 13
HELIX 52 AF7 ALA C 520 LEU C 533 1 14
HELIX 53 AF8 ASP C 534 LEU C 550 1 17
HELIX 54 AF9 LEU C 550 LEU C 555 1 6
HELIX 55 AG1 ASN C 562 GLY C 567 1 6
HELIX 56 AG2 THR C 573 GLY C 591 1 19
HELIX 57 AG3 ASN C 599 ILE C 603 5 5
HELIX 58 AG4 PRO C 850 ASN C 852 5 3
HELIX 59 AG5 THR C 911 LYS C 916 1 6
HELIX 60 AG6 ASP D 2 CYS D 14 1 13
HELIX 61 AG7 THR D 49 LYS D 55 1 7
HELIX 62 AG8 LYS D 60 ASN D 70 1 11
HELIX 63 AG9 ASN D 70 ILE D 75 1 6
HELIX 64 AH1 LYS D 87 THR D 102 1 16
HELIX 65 AH2 THR E 107 GLY E 118 1 12
HELIX 66 AH3 ARG E 129 LEU E 143 1 15
HELIX 67 AH4 GLY E 159 ASP E 170 1 12
HELIX 68 AH5 ASP E 170 PHE E 178 1 9
HELIX 69 AH6 ASP E 191 ASP E 207 1 17
HELIX 70 AH7 ASN E 219 ARG E 233 1 15
HELIX 71 AH8 ASP E 247 ASP E 255 1 9
HELIX 72 AH9 GLY E 287 ASN E 300 1 14
HELIX 73 AI1 GLN E 309 LYS E 318 1 10
HELIX 74 AI2 SER E 320 PHE E 334 1 15
HELIX 75 AI3 ARG E 337 LYS E 348 1 12
HELIX 76 AI4 ALA E 363 MET E 374 1 12
HELIX 77 AI5 ARG E 376 LEU E 386 1 11
HELIX 78 AI6 THR E 397 ASP E 405 1 9
HELIX 79 AI7 GLU E 407 LYS E 421 1 15
HELIX 80 AI8 HIS E 438 TYR E 467 1 30
HELIX 81 AI9 ASP E 479 LYS E 495 1 17
HELIX 82 AJ1 MET E 496 MET E 504 1 9
HELIX 83 AJ2 SER E 506 GLY E 518 1 13
HELIX 84 AJ3 ALA E 520 LEU E 533 1 14
HELIX 85 AJ4 ASP E 534 LEU E 550 1 17
HELIX 86 AJ5 LEU E 550 LEU E 555 1 6
HELIX 87 AJ6 ASN E 562 GLY E 567 1 6
HELIX 88 AJ7 THR E 573 GLY E 591 1 19
HELIX 89 AJ8 ASN E 599 ILE E 603 5 5
HELIX 90 AJ9 PRO E 850 ASN E 852 5 3
HELIX 91 AK1 THR E 911 LYS E 916 1 6
HELIX 92 AK2 ASP F 2 CYS F 14 1 13
HELIX 93 AK3 THR F 49 LYS F 55 1 7
HELIX 94 AK4 LYS F 60 ASN F 70 1 11
HELIX 95 AK5 ASN F 70 ILE F 75 1 6
HELIX 96 AK6 LYS F 87 THR F 102 1 16
HELIX 97 AK7 THR G 107 GLY G 118 1 12
HELIX 98 AK8 ARG G 129 LEU G 143 1 15
HELIX 99 AK9 GLY G 159 ASP G 170 1 12
HELIX 100 AL1 ASP G 170 PHE G 178 1 9
HELIX 101 AL2 ASP G 191 ASP G 207 1 17
HELIX 102 AL3 ASN G 219 ARG G 233 1 15
HELIX 103 AL4 ASP G 247 ASP G 255 1 9
HELIX 104 AL5 GLY G 287 ASN G 300 1 14
HELIX 105 AL6 PRO G 307 LYS G 318 1 12
HELIX 106 AL7 SER G 320 PHE G 334 1 15
HELIX 107 AL8 ARG G 337 LYS G 348 1 12
HELIX 108 AL9 ALA G 363 MET G 374 1 12
HELIX 109 AM1 ARG G 376 LEU G 386 1 11
HELIX 110 AM2 THR G 397 ASP G 405 1 9
HELIX 111 AM3 GLU G 407 LYS G 421 1 15
HELIX 112 AM4 HIS G 438 TYR G 467 1 30
HELIX 113 AM5 ASP G 479 LYS G 495 1 17
HELIX 114 AM6 MET G 496 MET G 504 1 9
HELIX 115 AM7 SER G 506 GLY G 518 1 13
HELIX 116 AM8 ALA G 520 LEU G 533 1 14
HELIX 117 AM9 ASP G 534 LEU G 550 1 17
HELIX 118 AN1 LEU G 550 LEU G 555 1 6
HELIX 119 AN2 ASN G 562 GLY G 567 1 6
HELIX 120 AN3 THR G 573 GLY G 591 1 19
HELIX 121 AN4 ASN G 599 ILE G 603 5 5
HELIX 122 AN5 PRO G 850 ASN G 852 5 3
HELIX 123 AN6 THR G 911 LYS G 916 1 6
HELIX 124 AN7 ASP H 2 CYS H 14 1 13
HELIX 125 AN8 THR H 49 LYS H 55 1 7
HELIX 126 AN9 LYS H 60 ASN H 70 1 11
HELIX 127 AO1 ASN H 70 ILE H 75 1 6
HELIX 128 AO2 LYS H 87 THR H 102 1 16
HELIX 129 AO3 THR I 107 GLY I 118 1 12
HELIX 130 AO4 ARG I 129 LEU I 143 1 15
HELIX 131 AO5 GLY I 159 ASP I 170 1 12
HELIX 132 AO6 ASP I 170 PHE I 178 1 9
HELIX 133 AO7 ASP I 191 ASP I 207 1 17
HELIX 134 AO8 ASN I 219 ARG I 233 1 15
HELIX 135 AO9 ASP I 247 ASP I 255 1 9
HELIX 136 AP1 GLY I 287 ASN I 300 1 14
HELIX 137 AP2 PRO I 307 LYS I 318 1 12
HELIX 138 AP3 SER I 320 PHE I 334 1 15
HELIX 139 AP4 ARG I 337 LYS I 348 1 12
HELIX 140 AP5 ALA I 363 MET I 374 1 12
HELIX 141 AP6 ARG I 376 LEU I 386 1 11
HELIX 142 AP7 THR I 397 ASP I 405 1 9
HELIX 143 AP8 GLU I 407 LYS I 421 1 15
HELIX 144 AP9 HIS I 438 TYR I 467 1 30
HELIX 145 AQ1 ASP I 479 LYS I 495 1 17
HELIX 146 AQ2 MET I 496 MET I 504 1 9
HELIX 147 AQ3 SER I 506 GLY I 518 1 13
HELIX 148 AQ4 ALA I 520 LEU I 533 1 14
HELIX 149 AQ5 ASP I 534 LEU I 550 1 17
HELIX 150 AQ6 LEU I 550 LEU I 555 1 6
HELIX 151 AQ7 ASN I 562 GLY I 567 1 6
HELIX 152 AQ8 THR I 573 GLY I 591 1 19
HELIX 153 AQ9 ASN I 599 ILE I 603 5 5
HELIX 154 AR1 PRO I 850 ASN I 852 5 3
HELIX 155 AR2 THR I 911 LYS I 916 1 6
HELIX 156 AR3 ASP J 2 CYS J 14 1 13
HELIX 157 AR4 THR J 49 LYS J 55 1 7
HELIX 158 AR5 LYS J 60 ASN J 70 1 11
HELIX 159 AR6 ASN J 70 ILE J 75 1 6
HELIX 160 AR7 LYS J 87 THR J 102 1 16
HELIX 161 AR8 THR K 107 GLY K 118 1 12
HELIX 162 AR9 ARG K 129 LEU K 143 1 15
HELIX 163 AS1 GLY K 159 ASP K 170 1 12
HELIX 164 AS2 ASP K 170 PHE K 178 1 9
HELIX 165 AS3 ASP K 191 ASP K 207 1 17
HELIX 166 AS4 ASN K 219 ARG K 233 1 15
HELIX 167 AS5 ASP K 247 ASP K 255 1 9
HELIX 168 AS6 GLY K 287 ASN K 300 1 14
HELIX 169 AS7 PRO K 307 LYS K 318 1 12
HELIX 170 AS8 SER K 320 PHE K 334 1 15
HELIX 171 AS9 ARG K 337 LYS K 348 1 12
HELIX 172 AT1 ALA K 363 MET K 374 1 12
HELIX 173 AT2 ARG K 376 LEU K 386 1 11
HELIX 174 AT3 THR K 397 ASP K 405 1 9
HELIX 175 AT4 GLU K 407 LYS K 421 1 15
HELIX 176 AT5 HIS K 438 TYR K 467 1 30
HELIX 177 AT6 ASP K 479 LYS K 495 1 17
HELIX 178 AT7 MET K 496 MET K 504 1 9
HELIX 179 AT8 SER K 506 GLY K 518 1 13
HELIX 180 AT9 ALA K 520 LEU K 533 1 14
HELIX 181 AU1 ASP K 534 LEU K 550 1 17
HELIX 182 AU2 LEU K 550 LEU K 555 1 6
HELIX 183 AU3 ASN K 562 GLY K 567 1 6
HELIX 184 AU4 THR K 573 GLY K 591 1 19
HELIX 185 AU5 ASN K 599 ILE K 603 5 5
HELIX 186 AU6 PRO K 850 ASN K 852 5 3
HELIX 187 AU7 THR K 911 LYS K 916 1 6
HELIX 188 AU8 ASP L 2 CYS L 14 1 13
HELIX 189 AU9 THR L 49 LYS L 55 1 7
HELIX 190 AV1 LYS L 60 ASN L 70 1 11
HELIX 191 AV2 ASN L 70 ILE L 75 1 6
HELIX 192 AV3 LYS L 87 THR L 102 1 16
HELIX 193 AV4 THR M 107 GLY M 118 1 12
HELIX 194 AV5 ARG M 129 LEU M 143 1 15
HELIX 195 AV6 GLY M 159 ASP M 170 1 12
HELIX 196 AV7 ASP M 170 PHE M 178 1 9
HELIX 197 AV8 ASP M 191 ASP M 207 1 17
HELIX 198 AV9 ASN M 219 ARG M 233 1 15
HELIX 199 AW1 ASP M 247 ASP M 255 1 9
HELIX 200 AW2 GLY M 287 ASN M 300 1 14
HELIX 201 AW3 PRO M 307 LYS M 318 1 12
HELIX 202 AW4 SER M 320 PHE M 334 1 15
HELIX 203 AW5 ARG M 337 LYS M 348 1 12
HELIX 204 AW6 ALA M 363 MET M 374 1 12
HELIX 205 AW7 ARG M 376 LEU M 386 1 11
HELIX 206 AW8 THR M 397 ASP M 405 1 9
HELIX 207 AW9 GLU M 407 LYS M 421 1 15
HELIX 208 AX1 HIS M 438 TYR M 467 1 30
HELIX 209 AX2 ASP M 479 LYS M 495 1 17
HELIX 210 AX3 MET M 496 MET M 504 1 9
HELIX 211 AX4 SER M 506 GLY M 518 1 13
HELIX 212 AX5 ALA M 520 LEU M 533 1 14
HELIX 213 AX6 ASP M 534 LEU M 550 1 17
HELIX 214 AX7 LEU M 550 LEU M 555 1 6
HELIX 215 AX8 ASN M 562 GLY M 567 1 6
HELIX 216 AX9 THR M 573 GLY M 591 1 19
HELIX 217 AY1 ASN M 599 ILE M 603 5 5
HELIX 218 AY2 PRO M 850 ASN M 852 5 3
HELIX 219 AY3 THR M 911 LYS M 916 1 6
HELIX 220 AY4 ASP N 2 CYS N 14 1 13
HELIX 221 AY5 THR N 49 LYS N 55 1 7
HELIX 222 AY6 LYS N 60 ASN N 70 1 11
HELIX 223 AY7 ASN N 70 ILE N 75 1 6
HELIX 224 AY8 LYS N 87 THR N 102 1 16
HELIX 225 AY9 ASP O 2 LYS O 18 1 17
HELIX 226 AZ1 LYS O 21 ASP O 32 1 12
HELIX 227 AZ2 THR O 36 ASN O 45 1 10
HELIX 228 AZ3 THR O 48 LEU O 61 1 14
HELIX 229 AZ4 ASP O 64 GLU O 78 1 15
HELIX 230 AZ5 TYR O 80 HIS O 88 1 9
HELIX 231 AZ6 ASP O 89 ILE O 91 5 3
HELIX 232 AZ7 ASP P 2 LYS P 18 1 17
HELIX 233 AZ8 LYS P 21 ASP P 32 1 12
HELIX 234 AZ9 THR P 36 ASN P 45 1 10
HELIX 235 BA1 THR P 48 LYS P 62 1 15
HELIX 236 BA2 ASP P 64 GLU P 78 1 15
HELIX 237 BA3 TYR P 80 HIS P 88 1 9
HELIX 238 BA4 ASP P 89 ILE P 91 5 3
HELIX 239 BA5 ASP Q 2 LYS Q 18 1 17
HELIX 240 BA6 LYS Q 21 GLY Q 33 1 13
HELIX 241 BA7 THR Q 36 ASN Q 45 1 10
HELIX 242 BA8 THR Q 48 LYS Q 62 1 15
HELIX 243 BA9 ASP Q 64 GLU Q 78 1 15
HELIX 244 BB1 TYR Q 80 HIS Q 88 1 9
HELIX 245 BB2 ASP Q 89 ILE Q 91 5 3
HELIX 246 BB3 ASP R 2 LYS R 18 1 17
HELIX 247 BB4 LYS R 21 ASP R 32 1 12
HELIX 248 BB5 THR R 36 ASN R 45 1 10
HELIX 249 BB6 THR R 48 LYS R 62 1 15
HELIX 250 BB7 ASP R 64 GLU R 78 1 15
HELIX 251 BB8 TYR R 80 HIS R 88 1 9
HELIX 252 BB9 ASP R 89 ILE R 91 5 3
HELIX 253 BC1 ASP S 2 CYS S 12 1 11
HELIX 254 BC2 CYS S 12 LEU S 20 1 9
HELIX 255 BC3 LEU S 25 ARG S 32 1 8
HELIX 256 BC4 ARG S 36 ARG S 45 1 10
HELIX 257 BC5 SER S 50 GLU S 63 1 14
HELIX 258 BC6 GLN S 68 ASP S 79 1 12
HELIX 259 BC7 GLN S 82 ALA S 95 1 14
HELIX 260 BC8 ASP T 2 CYS T 12 1 11
HELIX 261 BC9 CYS T 12 LEU T 20 1 9
HELIX 262 BD1 LEU T 25 ARG T 32 1 8
HELIX 263 BD2 ARG T 36 ARG T 45 1 10
HELIX 264 BD3 SER T 50 GLU T 63 1 14
HELIX 265 BD4 GLN T 68 ASP T 79 1 12
HELIX 266 BD5 GLN T 82 ALA T 95 1 14
HELIX 267 BD6 ASP U 2 CYS U 12 1 11
HELIX 268 BD7 CYS U 12 GLU U 18 1 7
HELIX 269 BD8 LEU U 25 ARG U 32 1 8
HELIX 270 BD9 ARG U 36 ARG U 45 1 10
HELIX 271 BE1 SER U 50 GLU U 63 1 14
HELIX 272 BE2 GLN U 68 ASP U 79 1 12
HELIX 273 BE3 GLN U 82 ALA U 95 1 14
HELIX 274 BE4 ASP V 2 CYS V 12 1 11
HELIX 275 BE5 CYS V 12 LEU V 20 1 9
HELIX 276 BE6 LEU V 25 ARG V 32 1 8
HELIX 277 BE7 ARG V 36 ARG V 45 1 10
HELIX 278 BE8 SER V 50 GLU V 63 1 14
HELIX 279 BE9 GLN V 68 ASP V 79 1 12
HELIX 280 BF1 GLN V 82 ALA V 95 1 14
HELIX 281 BF2 ASP W 2 HIS W 12 1 11
HELIX 282 BF3 HIS W 12 ILE W 20 1 9
HELIX 283 BF4 LYS W 21 TYR W 24 5 4
HELIX 284 BF5 ILE W 25 ASP W 32 1 8
HELIX 285 BF6 THR W 36 ASN W 45 1 10
HELIX 286 BF7 THR W 48 LEU W 61 1 14
HELIX 287 BF8 ASP W 64 GLU W 78 1 15
HELIX 288 BF9 TYR W 80 ASP W 89 1 10
HELIX 289 BG1 ASP X 2 ILE X 20 1 19
HELIX 290 BG2 LYS X 21 GLY X 33 1 13
HELIX 291 BG3 THR X 36 GLU X 46 1 11
HELIX 292 BG4 THR X 48 LYS X 62 1 15
HELIX 293 BG5 ASP X 64 GLU X 78 1 15
HELIX 294 BG6 TYR X 80 ASP X 89 1 10
HELIX 295 BG7 ASP Y 2 CYS Y 12 1 11
HELIX 296 BG8 CYS Y 12 LEU Y 20 1 9
HELIX 297 BG9 LEU Y 25 ARG Y 32 1 8
HELIX 298 BH1 ARG Y 36 ARG Y 45 1 10
HELIX 299 BH2 SER Y 50 GLU Y 63 1 14
HELIX 300 BH3 GLN Y 68 THR Y 80 1 13
HELIX 301 BH4 GLN Y 82 GLN Y 94 1 13
SHEET 1 AA1 5 VAL A 182 GLY A 188 0
SHEET 2 AA1 5 LEU A 239 ASP A 244 1 O ILE A 241 N VAL A 185
SHEET 3 AA1 5 ILE A 260 THR A 264 1 O LEU A 261 N LEU A 240
SHEET 4 AA1 5 TRP A 149 HIS A 153 1 N ILE A 152 O THR A 264
SHEET 5 AA1 5 LYS A 277 PRO A 281 1 O TYR A 278 N THR A 151
SHEET 1 AA2 2 VAL A 395 PRO A 396 0
SHEET 2 AA2 2 ARG A 434 TYR A 435 -1 O TYR A 435 N VAL A 395
SHEET 1 AA3 4 LEU A 609 VAL A 611 0
SHEET 2 AA3 4 ILE A 906 GLU A 910 -1 O ILE A 906 N VAL A 611
SHEET 3 AA3 4 SER A 896 SER A 901 -1 N PHE A 897 O TRP A 909
SHEET 4 AA3 4 VAL A 885 PHE A 890 -1 N GLY A 887 O SER A 900
SHEET 1 AA4 4 ALA A 621 PHE A 623 0
SHEET 2 AA4 4 ILE A 630 SER A 632 -1 O ALA A 631 N CYS A 622
SHEET 3 AA4 4 GLN A 640 LYS A 643 -1 O PHE A 642 N ILE A 630
SHEET 4 AA4 4 GLU A 648 GLU A 652 -1 O LEU A 650 N VAL A 641
SHEET 1 AA5 4 VAL A 660 PHE A 665 0
SHEET 2 AA5 4 PHE A 671 SER A 676 -1 O CYS A 675 N CYS A 662
SHEET 3 AA5 4 VAL A 681 ASN A 685 -1 O TRP A 684 N ILE A 672
SHEET 4 AA5 4 LEU A 691 TYR A 695 -1 O TYR A 695 N VAL A 681
SHEET 1 AA6 4 VAL A 702 PHE A 707 0
SHEET 2 AA6 4 LEU A 715 SER A 720 -1 O GLY A 719 N ASN A 703
SHEET 3 AA6 4 LEU A 725 ASP A 729 -1 O TRP A 728 N LEU A 716
SHEET 4 AA6 4 CYS A 735 MET A 739 -1 O ASN A 737 N LEU A 727
SHEET 1 AA7 4 VAL A 746 CYS A 749 0
SHEET 2 AA7 4 LEU A 757 SER A 762 -1 O CYS A 761 N HIS A 748
SHEET 3 AA7 4 LYS A 768 ASP A 771 -1 O TRP A 770 N LEU A 758
SHEET 4 AA7 4 ASN A 776 LYS A 779 -1 O LYS A 779 N LEU A 769
SHEET 1 AA8 4 CYS A 804 TRP A 806 0
SHEET 2 AA8 4 ILE A 813 ALA A 817 -1 O MET A 814 N SER A 805
SHEET 3 AA8 4 LYS A 820 ASP A 825 -1 O PHE A 822 N VAL A 815
SHEET 4 AA8 4 GLY A 830 GLY A 833 -1 O GLY A 830 N ASP A 825
SHEET 1 AA9 3 LEU A 854 ALA A 858 0
SHEET 2 AA9 3 VAL A 864 ASN A 868 -1 O TRP A 867 N ALA A 855
SHEET 3 AA9 3 SER A 873 ALA A 876 -1 O VAL A 875 N LEU A 866
SHEET 1 AB1 3 VAL A 928 PHE A 930 0
SHEET 2 AB1 3 VAL A 935 VAL A 937 -1 O MET A 936 N VAL A 929
SHEET 3 AB1 3 ILE A 949 ASN A 950 -1 O ILE A 949 N VAL A 937
SHEET 1 AB2 2 LEU A 946 GLN A 947 0
SHEET 2 AB2 2 TYR A 958 LEU A 959 -1 O LEU A 959 N LEU A 946
SHEET 1 AB3 2 CYS A 967 LEU A 969 0
SHEET 2 AB3 2 ILE A 976 PHE A 978 -1 O ALA A 977 N CYS A 968
SHEET 1 AB4 2 ILE A 985 GLU A 986 0
SHEET 2 AB4 2 SER A 998 ARG A 999 -1 O ARG A 999 N ILE A 985
SHEET 1 AB5 4 ILE A1009 PHE A1011 0
SHEET 2 AB5 4 LEU A1018 SER A1020 -1 O ILE A1019 N GLN A1010
SHEET 3 AB5 4 ILE A1027 ASN A1031 -1 O GLN A1028 N SER A1020
SHEET 4 AB5 4 LYS A1036 LEU A1040 -1 O LEU A1040 N ILE A1027
SHEET 1 AB6 4 ASP A1049 LEU A1052 0
SHEET 2 AB6 4 ARG A1057 TRP A1061 -1 O TRP A1061 N ASP A1049
SHEET 3 AB6 4 VAL A1067 ASN A1071 -1 O TRP A1070 N LEU A1058
SHEET 4 AB6 4 LYS A1079 PHE A1081 -1 O PHE A1081 N VAL A1067
SHEET 1 AB7 4 SER A1090 ILE A1093 0
SHEET 2 AB7 4 SER A1101 SER A1104 -1 O SER A1102 N ASP A1092
SHEET 3 AB7 4 ALA A1109 TRP A1112 -1 O TRP A1112 N SER A1101
SHEET 4 AB7 4 HIS A1121 LEU A1123 -1 O HIS A1121 N ILE A1111
SHEET 1 AB8 2 CYS A1132 PHE A1135 0
SHEET 2 AB8 2 LEU A1142 GLY A1145 -1 O GLY A1145 N CYS A1132
SHEET 1 AB9 3 ASP A1182 PHE A1185 0
SHEET 2 AB9 3 MET A1191 ALA A1195 -1 O ILE A1193 N CYS A1184
SHEET 3 AB9 3 ILE A1199 ASN A1203 -1 O TRP A1202 N LEU A1192
SHEET 1 AC1 2 VAL A1233 VAL A1235 0
SHEET 2 AC1 2 LEU A1241 ILE A1243 -1 O TYR A1242 N THR A1234
SHEET 1 AC2 5 VAL C 182 GLY C 188 0
SHEET 2 AC2 5 LEU C 239 ASP C 244 1 O ILE C 241 N VAL C 185
SHEET 3 AC2 5 ILE C 260 THR C 264 1 O LEU C 261 N LEU C 240
SHEET 4 AC2 5 TRP C 149 HIS C 153 1 N ILE C 152 O THR C 264
SHEET 5 AC2 5 LYS C 277 PRO C 281 1 O TYR C 278 N THR C 151
SHEET 1 AC3 2 VAL C 395 PRO C 396 0
SHEET 2 AC3 2 ARG C 434 TYR C 435 -1 O TYR C 435 N VAL C 395
SHEET 1 AC4 4 LEU C 609 VAL C 611 0
SHEET 2 AC4 4 ILE C 906 GLU C 910 -1 O ILE C 906 N VAL C 611
SHEET 3 AC4 4 SER C 896 SER C 901 -1 N PHE C 897 O TRP C 909
SHEET 4 AC4 4 VAL C 885 PHE C 890 -1 N GLY C 887 O SER C 900
SHEET 1 AC5 4 ALA C 621 PHE C 623 0
SHEET 2 AC5 4 ILE C 630 SER C 632 -1 O ALA C 631 N CYS C 622
SHEET 3 AC5 4 GLN C 640 LYS C 643 -1 O PHE C 642 N ILE C 630
SHEET 4 AC5 4 GLU C 648 GLU C 652 -1 O LEU C 650 N VAL C 641
SHEET 1 AC6 4 VAL C 660 PHE C 665 0
SHEET 2 AC6 4 PHE C 671 SER C 676 -1 O CYS C 675 N CYS C 662
SHEET 3 AC6 4 VAL C 681 ASN C 685 -1 O TRP C 684 N ILE C 672
SHEET 4 AC6 4 LEU C 691 TYR C 695 -1 O TYR C 695 N VAL C 681
SHEET 1 AC7 4 VAL C 702 PHE C 707 0
SHEET 2 AC7 4 LEU C 715 SER C 720 -1 O GLY C 719 N ASN C 703
SHEET 3 AC7 4 LEU C 725 ASP C 729 -1 O TRP C 728 N LEU C 716
SHEET 4 AC7 4 CYS C 735 MET C 739 -1 O ASN C 737 N LEU C 727
SHEET 1 AC8 4 VAL C 746 CYS C 749 0
SHEET 2 AC8 4 LEU C 757 SER C 762 -1 O CYS C 761 N HIS C 748
SHEET 3 AC8 4 LYS C 768 ASP C 771 -1 O TRP C 770 N LEU C 758
SHEET 4 AC8 4 ASN C 776 LYS C 779 -1 O LYS C 779 N LEU C 769
SHEET 1 AC9 4 CYS C 804 TRP C 806 0
SHEET 2 AC9 4 ILE C 813 ALA C 817 -1 O MET C 814 N SER C 805
SHEET 3 AC9 4 LYS C 820 ASP C 825 -1 O PHE C 822 N VAL C 815
SHEET 4 AC9 4 GLY C 830 GLY C 833 -1 O GLY C 830 N ASP C 825
SHEET 1 AD1 3 LEU C 854 ALA C 858 0
SHEET 2 AD1 3 VAL C 864 ASN C 868 -1 O TRP C 867 N ALA C 855
SHEET 3 AD1 3 SER C 873 ALA C 876 -1 O VAL C 875 N LEU C 866
SHEET 1 AD2 3 VAL C 928 PHE C 930 0
SHEET 2 AD2 3 VAL C 935 VAL C 937 -1 O MET C 936 N VAL C 929
SHEET 3 AD2 3 ILE C 949 ASN C 950 -1 O ILE C 949 N VAL C 937
SHEET 1 AD3 2 LEU C 946 GLN C 947 0
SHEET 2 AD3 2 TYR C 958 LEU C 959 -1 O LEU C 959 N LEU C 946
SHEET 1 AD4 2 CYS C 967 LEU C 969 0
SHEET 2 AD4 2 ILE C 976 PHE C 978 -1 O ALA C 977 N CYS C 968
SHEET 1 AD5 2 ILE C 985 GLU C 986 0
SHEET 2 AD5 2 SER C 998 ARG C 999 -1 O ARG C 999 N ILE C 985
SHEET 1 AD6 4 ILE C1009 PHE C1011 0
SHEET 2 AD6 4 LEU C1018 SER C1020 -1 O ILE C1019 N GLN C1010
SHEET 3 AD6 4 ILE C1027 ASN C1031 -1 O GLN C1028 N SER C1020
SHEET 4 AD6 4 LYS C1036 LEU C1040 -1 O LEU C1040 N ILE C1027
SHEET 1 AD7 4 ASP C1049 LEU C1052 0
SHEET 2 AD7 4 ARG C1057 TRP C1061 -1 O TRP C1061 N ASP C1049
SHEET 3 AD7 4 VAL C1067 ASN C1071 -1 O TRP C1070 N LEU C1058
SHEET 4 AD7 4 LYS C1079 PHE C1081 -1 O PHE C1081 N VAL C1067
SHEET 1 AD8 4 SER C1090 ILE C1093 0
SHEET 2 AD8 4 SER C1101 SER C1104 -1 O SER C1102 N ASP C1092
SHEET 3 AD8 4 ALA C1109 TRP C1112 -1 O TRP C1112 N SER C1101
SHEET 4 AD8 4 HIS C1121 LEU C1123 -1 O HIS C1121 N ILE C1111
SHEET 1 AD9 2 CYS C1132 PHE C1135 0
SHEET 2 AD9 2 LEU C1142 GLY C1145 -1 O GLY C1145 N CYS C1132
SHEET 1 AE1 3 ASP C1182 PHE C1185 0
SHEET 2 AE1 3 MET C1191 ALA C1195 -1 O ILE C1193 N CYS C1184
SHEET 3 AE1 3 ILE C1199 ASN C1203 -1 O TRP C1202 N LEU C1192
SHEET 1 AE2 2 VAL C1233 VAL C1235 0
SHEET 2 AE2 2 LEU C1241 ILE C1243 -1 O TYR C1242 N THR C1234
SHEET 1 AE3 5 VAL E 182 GLY E 188 0
SHEET 2 AE3 5 LEU E 239 ASP E 244 1 O ILE E 241 N VAL E 185
SHEET 3 AE3 5 ILE E 260 THR E 264 1 O LEU E 261 N LEU E 240
SHEET 4 AE3 5 TRP E 149 HIS E 153 1 N ILE E 152 O THR E 264
SHEET 5 AE3 5 LYS E 277 PRO E 281 1 O TYR E 278 N THR E 151
SHEET 1 AE4 2 VAL E 395 PRO E 396 0
SHEET 2 AE4 2 ARG E 434 TYR E 435 -1 O TYR E 435 N VAL E 395
SHEET 1 AE5 4 LEU E 609 VAL E 611 0
SHEET 2 AE5 4 ILE E 906 GLU E 910 -1 O ILE E 906 N VAL E 611
SHEET 3 AE5 4 SER E 896 SER E 901 -1 N PHE E 897 O TRP E 909
SHEET 4 AE5 4 VAL E 885 PHE E 890 -1 N GLY E 887 O SER E 900
SHEET 1 AE6 4 ALA E 621 PHE E 623 0
SHEET 2 AE6 4 ILE E 630 SER E 632 -1 O ALA E 631 N CYS E 622
SHEET 3 AE6 4 GLN E 640 LYS E 643 -1 O PHE E 642 N ILE E 630
SHEET 4 AE6 4 GLU E 648 GLU E 652 -1 O LEU E 650 N VAL E 641
SHEET 1 AE7 4 VAL E 660 PHE E 665 0
SHEET 2 AE7 4 PHE E 671 SER E 676 -1 O CYS E 675 N CYS E 662
SHEET 3 AE7 4 VAL E 681 ASN E 685 -1 O TRP E 684 N ILE E 672
SHEET 4 AE7 4 LEU E 691 TYR E 695 -1 O TYR E 695 N VAL E 681
SHEET 1 AE8 4 VAL E 702 PHE E 707 0
SHEET 2 AE8 4 LEU E 715 SER E 720 -1 O GLY E 719 N ASN E 703
SHEET 3 AE8 4 LEU E 725 ASP E 729 -1 O TRP E 728 N LEU E 716
SHEET 4 AE8 4 CYS E 735 MET E 739 -1 O ASN E 737 N LEU E 727
SHEET 1 AE9 4 VAL E 746 CYS E 749 0
SHEET 2 AE9 4 LEU E 757 SER E 762 -1 O CYS E 761 N HIS E 748
SHEET 3 AE9 4 LYS E 768 ASP E 771 -1 O TRP E 770 N LEU E 758
SHEET 4 AE9 4 ASN E 776 LYS E 779 -1 O LYS E 779 N LEU E 769
SHEET 1 AF1 4 CYS E 804 TRP E 806 0
SHEET 2 AF1 4 ILE E 813 ALA E 817 -1 O MET E 814 N SER E 805
SHEET 3 AF1 4 LYS E 820 ASP E 825 -1 O PHE E 822 N VAL E 815
SHEET 4 AF1 4 GLY E 830 GLY E 833 -1 O GLY E 830 N ASP E 825
SHEET 1 AF2 3 LEU E 854 ALA E 858 0
SHEET 2 AF2 3 VAL E 864 ASN E 868 -1 O TRP E 867 N ALA E 855
SHEET 3 AF2 3 SER E 873 ALA E 876 -1 O VAL E 875 N LEU E 866
SHEET 1 AF3 3 VAL E 928 PHE E 930 0
SHEET 2 AF3 3 VAL E 935 VAL E 937 -1 O MET E 936 N VAL E 929
SHEET 3 AF3 3 ILE E 949 ASN E 950 -1 O ILE E 949 N VAL E 937
SHEET 1 AF4 2 LEU E 946 GLN E 947 0
SHEET 2 AF4 2 TYR E 958 LEU E 959 -1 O LEU E 959 N LEU E 946
SHEET 1 AF5 2 CYS E 967 LEU E 969 0
SHEET 2 AF5 2 ILE E 976 PHE E 978 -1 O ALA E 977 N CYS E 968
SHEET 1 AF6 2 ILE E 985 GLU E 986 0
SHEET 2 AF6 2 SER E 998 ARG E 999 -1 O ARG E 999 N ILE E 985
SHEET 1 AF7 4 ILE E1009 PHE E1011 0
SHEET 2 AF7 4 LEU E1018 SER E1020 -1 O ILE E1019 N GLN E1010
SHEET 3 AF7 4 ILE E1027 ASN E1031 -1 O GLN E1028 N SER E1020
SHEET 4 AF7 4 LYS E1036 LEU E1040 -1 O LEU E1040 N ILE E1027
SHEET 1 AF8 4 ASP E1049 LEU E1052 0
SHEET 2 AF8 4 ARG E1057 TRP E1061 -1 O TRP E1061 N ASP E1049
SHEET 3 AF8 4 VAL E1067 ASN E1071 -1 O TRP E1070 N LEU E1058
SHEET 4 AF8 4 LYS E1079 PHE E1081 -1 O PHE E1081 N VAL E1067
SHEET 1 AF9 4 SER E1090 ILE E1093 0
SHEET 2 AF9 4 SER E1101 SER E1104 -1 O SER E1102 N ASP E1092
SHEET 3 AF9 4 ALA E1109 TRP E1112 -1 O TRP E1112 N SER E1101
SHEET 4 AF9 4 HIS E1121 LEU E1123 -1 O HIS E1121 N ILE E1111
SHEET 1 AG1 2 CYS E1132 PHE E1135 0
SHEET 2 AG1 2 LEU E1142 GLY E1145 -1 O GLY E1145 N CYS E1132
SHEET 1 AG2 3 ASP E1182 PHE E1185 0
SHEET 2 AG2 3 MET E1191 ALA E1195 -1 O ILE E1193 N CYS E1184
SHEET 3 AG2 3 ILE E1199 ASN E1203 -1 O TRP E1202 N LEU E1192
SHEET 1 AG3 2 VAL E1233 VAL E1235 0
SHEET 2 AG3 2 LEU E1241 ILE E1243 -1 O TYR E1242 N THR E1234
SHEET 1 AG4 5 VAL G 182 GLY G 188 0
SHEET 2 AG4 5 LEU G 239 ASP G 244 1 O ILE G 241 N VAL G 185
SHEET 3 AG4 5 ILE G 260 THR G 264 1 O LEU G 261 N LEU G 240
SHEET 4 AG4 5 TRP G 149 HIS G 153 1 N ILE G 152 O THR G 264
SHEET 5 AG4 5 LYS G 277 PRO G 281 1 O TYR G 278 N THR G 151
SHEET 1 AG5 2 VAL G 395 PRO G 396 0
SHEET 2 AG5 2 ARG G 434 TYR G 435 -1 O TYR G 435 N VAL G 395
SHEET 1 AG6 4 LEU G 609 VAL G 611 0
SHEET 2 AG6 4 ILE G 906 GLU G 910 -1 O ILE G 906 N VAL G 611
SHEET 3 AG6 4 SER G 896 SER G 901 -1 N PHE G 897 O TRP G 909
SHEET 4 AG6 4 VAL G 885 PHE G 890 -1 N GLY G 887 O SER G 900
SHEET 1 AG7 4 ALA G 621 PHE G 623 0
SHEET 2 AG7 4 ILE G 630 SER G 632 -1 O ALA G 631 N CYS G 622
SHEET 3 AG7 4 GLN G 640 LYS G 643 -1 O PHE G 642 N ILE G 630
SHEET 4 AG7 4 GLU G 648 GLU G 652 -1 O LEU G 650 N VAL G 641
SHEET 1 AG8 4 VAL G 660 PHE G 665 0
SHEET 2 AG8 4 PHE G 671 SER G 676 -1 O CYS G 675 N CYS G 662
SHEET 3 AG8 4 VAL G 681 ASN G 685 -1 O TRP G 684 N ILE G 672
SHEET 4 AG8 4 LEU G 691 TYR G 695 -1 O TYR G 695 N VAL G 681
SHEET 1 AG9 4 VAL G 702 PHE G 707 0
SHEET 2 AG9 4 LEU G 715 SER G 720 -1 O GLY G 719 N ASN G 703
SHEET 3 AG9 4 LEU G 725 ASP G 729 -1 O TRP G 728 N LEU G 716
SHEET 4 AG9 4 CYS G 735 MET G 739 -1 O ASN G 737 N LEU G 727
SHEET 1 AH1 4 VAL G 746 CYS G 749 0
SHEET 2 AH1 4 LEU G 757 SER G 762 -1 O CYS G 761 N HIS G 748
SHEET 3 AH1 4 LYS G 768 ASP G 771 -1 O TRP G 770 N LEU G 758
SHEET 4 AH1 4 ASN G 776 LYS G 779 -1 O LYS G 779 N LEU G 769
SHEET 1 AH2 4 CYS G 804 TRP G 806 0
SHEET 2 AH2 4 ILE G 813 ALA G 817 -1 O MET G 814 N SER G 805
SHEET 3 AH2 4 LYS G 820 ASP G 825 -1 O PHE G 822 N VAL G 815
SHEET 4 AH2 4 GLY G 830 GLY G 833 -1 O GLY G 830 N ASP G 825
SHEET 1 AH3 3 LEU G 854 ALA G 858 0
SHEET 2 AH3 3 VAL G 864 ASN G 868 -1 O TRP G 867 N ALA G 855
SHEET 3 AH3 3 SER G 873 ALA G 876 -1 O VAL G 875 N LEU G 866
SHEET 1 AH4 3 VAL G 928 PHE G 930 0
SHEET 2 AH4 3 VAL G 935 VAL G 937 -1 O MET G 936 N VAL G 929
SHEET 3 AH4 3 ILE G 949 ASN G 950 -1 O ILE G 949 N VAL G 937
SHEET 1 AH5 2 LEU G 946 GLN G 947 0
SHEET 2 AH5 2 TYR G 958 LEU G 959 -1 O LEU G 959 N LEU G 946
SHEET 1 AH6 2 CYS G 967 LEU G 969 0
SHEET 2 AH6 2 ILE G 976 PHE G 978 -1 O ALA G 977 N CYS G 968
SHEET 1 AH7 2 ILE G 985 GLU G 986 0
SHEET 2 AH7 2 SER G 998 ARG G 999 -1 O ARG G 999 N ILE G 985
SHEET 1 AH8 4 ILE G1009 PHE G1011 0
SHEET 2 AH8 4 LEU G1018 SER G1020 -1 O ILE G1019 N GLN G1010
SHEET 3 AH8 4 ILE G1027 ASN G1031 -1 O GLN G1028 N SER G1020
SHEET 4 AH8 4 LYS G1036 LEU G1040 -1 O LEU G1040 N ILE G1027
SHEET 1 AH9 4 ASP G1049 LEU G1052 0
SHEET 2 AH9 4 ARG G1057 TRP G1061 -1 O TRP G1061 N ASP G1049
SHEET 3 AH9 4 VAL G1067 ASN G1071 -1 O TRP G1070 N LEU G1058
SHEET 4 AH9 4 LYS G1079 PHE G1081 -1 O PHE G1081 N VAL G1067
SHEET 1 AI1 4 SER G1090 ILE G1093 0
SHEET 2 AI1 4 SER G1101 SER G1104 -1 O SER G1102 N ASP G1092
SHEET 3 AI1 4 ALA G1109 TRP G1112 -1 O TRP G1112 N SER G1101
SHEET 4 AI1 4 HIS G1121 LEU G1123 -1 O HIS G1121 N ILE G1111
SHEET 1 AI2 2 CYS G1132 PHE G1135 0
SHEET 2 AI2 2 LEU G1142 GLY G1145 -1 O GLY G1145 N CYS G1132
SHEET 1 AI3 3 ASP G1182 PHE G1185 0
SHEET 2 AI3 3 MET G1191 ALA G1195 -1 O ILE G1193 N CYS G1184
SHEET 3 AI3 3 ILE G1199 ASN G1203 -1 O TRP G1202 N LEU G1192
SHEET 1 AI4 2 VAL G1233 VAL G1235 0
SHEET 2 AI4 2 LEU G1241 ILE G1243 -1 O TYR G1242 N THR G1234
SHEET 1 AI5 5 VAL I 182 GLY I 188 0
SHEET 2 AI5 5 LEU I 239 ASP I 244 1 O ILE I 241 N VAL I 185
SHEET 3 AI5 5 ILE I 260 THR I 264 1 O LEU I 261 N LEU I 240
SHEET 4 AI5 5 TRP I 149 HIS I 153 1 N ILE I 152 O THR I 264
SHEET 5 AI5 5 LYS I 277 PRO I 281 1 O TYR I 278 N THR I 151
SHEET 1 AI6 2 VAL I 395 PRO I 396 0
SHEET 2 AI6 2 ARG I 434 TYR I 435 -1 O TYR I 435 N VAL I 395
SHEET 1 AI7 4 LEU I 609 VAL I 611 0
SHEET 2 AI7 4 ILE I 906 GLU I 910 -1 O ILE I 906 N VAL I 611
SHEET 3 AI7 4 SER I 896 SER I 901 -1 N PHE I 897 O TRP I 909
SHEET 4 AI7 4 VAL I 885 PHE I 890 -1 N GLY I 887 O SER I 900
SHEET 1 AI8 4 ALA I 621 PHE I 623 0
SHEET 2 AI8 4 ILE I 630 SER I 632 -1 O ALA I 631 N CYS I 622
SHEET 3 AI8 4 GLN I 640 LYS I 643 -1 O PHE I 642 N ILE I 630
SHEET 4 AI8 4 GLU I 648 GLU I 652 -1 O LEU I 650 N VAL I 641
SHEET 1 AI9 4 VAL I 660 PHE I 665 0
SHEET 2 AI9 4 PHE I 671 SER I 676 -1 O CYS I 675 N CYS I 662
SHEET 3 AI9 4 VAL I 681 ASN I 685 -1 O TRP I 684 N ILE I 672
SHEET 4 AI9 4 LEU I 691 TYR I 695 -1 O TYR I 695 N VAL I 681
SHEET 1 AJ1 4 VAL I 702 PHE I 707 0
SHEET 2 AJ1 4 LEU I 715 SER I 720 -1 O GLY I 719 N ASN I 703
SHEET 3 AJ1 4 LEU I 725 ASP I 729 -1 O TRP I 728 N LEU I 716
SHEET 4 AJ1 4 CYS I 735 MET I 739 -1 O ASN I 737 N LEU I 727
SHEET 1 AJ2 4 VAL I 746 CYS I 749 0
SHEET 2 AJ2 4 LEU I 757 SER I 762 -1 O CYS I 761 N HIS I 748
SHEET 3 AJ2 4 LYS I 768 ASP I 771 -1 O TRP I 770 N LEU I 758
SHEET 4 AJ2 4 ASN I 776 LYS I 779 -1 O LYS I 779 N LEU I 769
SHEET 1 AJ3 4 CYS I 804 TRP I 806 0
SHEET 2 AJ3 4 ILE I 813 ALA I 817 -1 O MET I 814 N SER I 805
SHEET 3 AJ3 4 LYS I 820 ASP I 825 -1 O PHE I 822 N VAL I 815
SHEET 4 AJ3 4 GLY I 830 GLY I 833 -1 O GLY I 830 N ASP I 825
SHEET 1 AJ4 3 LEU I 854 ALA I 858 0
SHEET 2 AJ4 3 VAL I 864 ASN I 868 -1 O TRP I 867 N ALA I 855
SHEET 3 AJ4 3 SER I 873 ALA I 876 -1 O VAL I 875 N LEU I 866
SHEET 1 AJ5 3 VAL I 928 PHE I 930 0
SHEET 2 AJ5 3 VAL I 935 VAL I 937 -1 O MET I 936 N VAL I 929
SHEET 3 AJ5 3 ILE I 949 ASN I 950 -1 O ILE I 949 N VAL I 937
SHEET 1 AJ6 2 LEU I 946 GLN I 947 0
SHEET 2 AJ6 2 TYR I 958 LEU I 959 -1 O LEU I 959 N LEU I 946
SHEET 1 AJ7 2 CYS I 967 LEU I 969 0
SHEET 2 AJ7 2 ILE I 976 PHE I 978 -1 O ALA I 977 N CYS I 968
SHEET 1 AJ8 2 ILE I 985 GLU I 986 0
SHEET 2 AJ8 2 SER I 998 ARG I 999 -1 O ARG I 999 N ILE I 985
SHEET 1 AJ9 4 ILE I1009 PHE I1011 0
SHEET 2 AJ9 4 LEU I1018 SER I1020 -1 O ILE I1019 N GLN I1010
SHEET 3 AJ9 4 ILE I1027 ASN I1031 -1 O GLN I1028 N SER I1020
SHEET 4 AJ9 4 LYS I1036 LEU I1040 -1 O LEU I1040 N ILE I1027
SHEET 1 AK1 4 ASP I1049 LEU I1052 0
SHEET 2 AK1 4 ARG I1057 TRP I1061 -1 O TRP I1061 N ASP I1049
SHEET 3 AK1 4 VAL I1067 ASN I1071 -1 O TRP I1070 N LEU I1058
SHEET 4 AK1 4 LYS I1079 PHE I1081 -1 O PHE I1081 N VAL I1067
SHEET 1 AK2 4 SER I1090 ILE I1093 0
SHEET 2 AK2 4 SER I1101 SER I1104 -1 O SER I1102 N ASP I1092
SHEET 3 AK2 4 ALA I1109 TRP I1112 -1 O TRP I1112 N SER I1101
SHEET 4 AK2 4 HIS I1121 LEU I1123 -1 O HIS I1121 N ILE I1111
SHEET 1 AK3 2 CYS I1132 PHE I1135 0
SHEET 2 AK3 2 LEU I1142 GLY I1145 -1 O GLY I1145 N CYS I1132
SHEET 1 AK4 3 ASP I1182 PHE I1185 0
SHEET 2 AK4 3 MET I1191 ALA I1195 -1 O ILE I1193 N CYS I1184
SHEET 3 AK4 3 ILE I1199 ASN I1203 -1 O TRP I1202 N LEU I1192
SHEET 1 AK5 2 VAL I1233 VAL I1235 0
SHEET 2 AK5 2 LEU I1241 ILE I1243 -1 O TYR I1242 N THR I1234
SHEET 1 AK6 5 VAL K 182 GLY K 188 0
SHEET 2 AK6 5 LEU K 239 ASP K 244 1 O ILE K 241 N VAL K 185
SHEET 3 AK6 5 ILE K 260 THR K 264 1 O LEU K 261 N LEU K 240
SHEET 4 AK6 5 TRP K 149 HIS K 153 1 N ILE K 152 O THR K 264
SHEET 5 AK6 5 LYS K 277 PRO K 281 1 O TYR K 278 N THR K 151
SHEET 1 AK7 2 VAL K 395 PRO K 396 0
SHEET 2 AK7 2 ARG K 434 TYR K 435 -1 O TYR K 435 N VAL K 395
SHEET 1 AK8 4 LEU K 609 VAL K 611 0
SHEET 2 AK8 4 ILE K 906 GLU K 910 -1 O ILE K 906 N VAL K 611
SHEET 3 AK8 4 SER K 896 SER K 901 -1 N PHE K 897 O TRP K 909
SHEET 4 AK8 4 VAL K 885 PHE K 890 -1 N GLY K 887 O SER K 900
SHEET 1 AK9 4 ALA K 621 PHE K 623 0
SHEET 2 AK9 4 ILE K 630 SER K 632 -1 O ALA K 631 N CYS K 622
SHEET 3 AK9 4 GLN K 640 LYS K 643 -1 O PHE K 642 N ILE K 630
SHEET 4 AK9 4 GLU K 648 GLU K 652 -1 O LEU K 650 N VAL K 641
SHEET 1 AL1 4 VAL K 660 PHE K 665 0
SHEET 2 AL1 4 PHE K 671 SER K 676 -1 O CYS K 675 N CYS K 662
SHEET 3 AL1 4 VAL K 681 ASN K 685 -1 O TRP K 684 N ILE K 672
SHEET 4 AL1 4 LEU K 691 TYR K 695 -1 O TYR K 695 N VAL K 681
SHEET 1 AL2 4 VAL K 702 PHE K 707 0
SHEET 2 AL2 4 LEU K 715 SER K 720 -1 O GLY K 719 N ASN K 703
SHEET 3 AL2 4 LEU K 725 ASP K 729 -1 O TRP K 728 N LEU K 716
SHEET 4 AL2 4 CYS K 735 MET K 739 -1 O ASN K 737 N LEU K 727
SHEET 1 AL3 4 VAL K 746 CYS K 749 0
SHEET 2 AL3 4 LEU K 757 SER K 762 -1 O CYS K 761 N HIS K 748
SHEET 3 AL3 4 LYS K 768 ASP K 771 -1 O TRP K 770 N LEU K 758
SHEET 4 AL3 4 ASN K 776 LYS K 779 -1 O LYS K 779 N LEU K 769
SHEET 1 AL4 4 CYS K 804 TRP K 806 0
SHEET 2 AL4 4 ILE K 813 ALA K 817 -1 O MET K 814 N SER K 805
SHEET 3 AL4 4 LYS K 820 ASP K 825 -1 O PHE K 822 N VAL K 815
SHEET 4 AL4 4 GLY K 830 GLY K 833 -1 O GLY K 830 N ASP K 825
SHEET 1 AL5 3 LEU K 854 ALA K 858 0
SHEET 2 AL5 3 VAL K 864 ASN K 868 -1 O TRP K 867 N ALA K 855
SHEET 3 AL5 3 SER K 873 ALA K 876 -1 O VAL K 875 N LEU K 866
SHEET 1 AL6 3 VAL K 928 PHE K 930 0
SHEET 2 AL6 3 VAL K 935 VAL K 937 -1 O MET K 936 N VAL K 929
SHEET 3 AL6 3 ILE K 949 ASN K 950 -1 O ILE K 949 N VAL K 937
SHEET 1 AL7 2 LEU K 946 GLN K 947 0
SHEET 2 AL7 2 TYR K 958 LEU K 959 -1 O LEU K 959 N LEU K 946
SHEET 1 AL8 2 CYS K 967 LEU K 969 0
SHEET 2 AL8 2 ILE K 976 PHE K 978 -1 O ALA K 977 N CYS K 968
SHEET 1 AL9 2 ILE K 985 GLU K 986 0
SHEET 2 AL9 2 SER K 998 ARG K 999 -1 O ARG K 999 N ILE K 985
SHEET 1 AM1 4 ILE K1009 PHE K1011 0
SHEET 2 AM1 4 LEU K1018 SER K1020 -1 O ILE K1019 N GLN K1010
SHEET 3 AM1 4 ILE K1027 ASN K1031 -1 O GLN K1028 N SER K1020
SHEET 4 AM1 4 LYS K1036 LEU K1040 -1 O LEU K1040 N ILE K1027
SHEET 1 AM2 4 ASP K1049 LEU K1052 0
SHEET 2 AM2 4 ARG K1057 TRP K1061 -1 O TRP K1061 N ASP K1049
SHEET 3 AM2 4 VAL K1067 ASN K1071 -1 O TRP K1070 N LEU K1058
SHEET 4 AM2 4 LYS K1079 PHE K1081 -1 O PHE K1081 N VAL K1067
SHEET 1 AM3 4 SER K1090 ILE K1093 0
SHEET 2 AM3 4 SER K1101 SER K1104 -1 O SER K1102 N ASP K1092
SHEET 3 AM3 4 ALA K1109 TRP K1112 -1 O TRP K1112 N SER K1101
SHEET 4 AM3 4 HIS K1121 LEU K1123 -1 O HIS K1121 N ILE K1111
SHEET 1 AM4 2 CYS K1132 PHE K1135 0
SHEET 2 AM4 2 LEU K1142 GLY K1145 -1 O GLY K1145 N CYS K1132
SHEET 1 AM5 3 ASP K1182 PHE K1185 0
SHEET 2 AM5 3 MET K1191 ALA K1195 -1 O ILE K1193 N CYS K1184
SHEET 3 AM5 3 ILE K1199 ASN K1203 -1 O TRP K1202 N LEU K1192
SHEET 1 AM6 2 VAL K1233 VAL K1235 0
SHEET 2 AM6 2 LEU K1241 ILE K1243 -1 O TYR K1242 N THR K1234
SHEET 1 AM7 5 VAL M 182 GLY M 188 0
SHEET 2 AM7 5 LEU M 239 ASP M 244 1 O ILE M 241 N VAL M 185
SHEET 3 AM7 5 ILE M 260 THR M 264 1 O LEU M 261 N LEU M 240
SHEET 4 AM7 5 TRP M 149 HIS M 153 1 N ILE M 152 O THR M 264
SHEET 5 AM7 5 LYS M 277 PRO M 281 1 O TYR M 278 N THR M 151
SHEET 1 AM8 2 VAL M 395 PRO M 396 0
SHEET 2 AM8 2 ARG M 434 TYR M 435 -1 O TYR M 435 N VAL M 395
SHEET 1 AM9 4 LEU M 609 VAL M 611 0
SHEET 2 AM9 4 ILE M 906 GLU M 910 -1 O ILE M 906 N VAL M 611
SHEET 3 AM9 4 SER M 896 SER M 901 -1 N PHE M 897 O TRP M 909
SHEET 4 AM9 4 VAL M 885 PHE M 890 -1 N GLY M 887 O SER M 900
SHEET 1 AN1 4 ALA M 621 PHE M 623 0
SHEET 2 AN1 4 ILE M 630 SER M 632 -1 O ALA M 631 N CYS M 622
SHEET 3 AN1 4 GLN M 640 LYS M 643 -1 O PHE M 642 N ILE M 630
SHEET 4 AN1 4 GLU M 648 GLU M 652 -1 O LEU M 650 N VAL M 641
SHEET 1 AN2 4 VAL M 660 PHE M 665 0
SHEET 2 AN2 4 PHE M 671 SER M 676 -1 O CYS M 675 N CYS M 662
SHEET 3 AN2 4 VAL M 681 ASN M 685 -1 O TRP M 684 N ILE M 672
SHEET 4 AN2 4 LEU M 691 TYR M 695 -1 O TYR M 695 N VAL M 681
SHEET 1 AN3 4 VAL M 702 PHE M 707 0
SHEET 2 AN3 4 LEU M 715 SER M 720 -1 O GLY M 719 N ASN M 703
SHEET 3 AN3 4 LEU M 725 ASP M 729 -1 O TRP M 728 N LEU M 716
SHEET 4 AN3 4 CYS M 735 MET M 739 -1 O ASN M 737 N LEU M 727
SHEET 1 AN4 4 VAL M 746 CYS M 749 0
SHEET 2 AN4 4 LEU M 757 SER M 762 -1 O CYS M 761 N HIS M 748
SHEET 3 AN4 4 LYS M 768 ASP M 771 -1 O TRP M 770 N LEU M 758
SHEET 4 AN4 4 ASN M 776 LYS M 779 -1 O LYS M 779 N LEU M 769
SHEET 1 AN5 4 CYS M 804 TRP M 806 0
SHEET 2 AN5 4 ILE M 813 ALA M 817 -1 O MET M 814 N SER M 805
SHEET 3 AN5 4 LYS M 820 ASP M 825 -1 O PHE M 822 N VAL M 815
SHEET 4 AN5 4 GLY M 830 GLY M 833 -1 O GLY M 830 N ASP M 825
SHEET 1 AN6 3 LEU M 854 ALA M 858 0
SHEET 2 AN6 3 VAL M 864 ASN M 868 -1 O TRP M 867 N ALA M 855
SHEET 3 AN6 3 SER M 873 ALA M 876 -1 O VAL M 875 N LEU M 866
SHEET 1 AN7 3 VAL M 928 PHE M 930 0
SHEET 2 AN7 3 VAL M 935 VAL M 937 -1 O MET M 936 N VAL M 929
SHEET 3 AN7 3 ILE M 949 ASN M 950 -1 O ILE M 949 N VAL M 937
SHEET 1 AN8 2 LEU M 946 GLN M 947 0
SHEET 2 AN8 2 TYR M 958 LEU M 959 -1 O LEU M 959 N LEU M 946
SHEET 1 AN9 2 CYS M 967 LEU M 969 0
SHEET 2 AN9 2 ILE M 976 PHE M 978 -1 O ALA M 977 N CYS M 968
SHEET 1 AO1 2 ILE M 985 GLU M 986 0
SHEET 2 AO1 2 SER M 998 ARG M 999 -1 O ARG M 999 N ILE M 985
SHEET 1 AO2 4 ILE M1009 PHE M1011 0
SHEET 2 AO2 4 LEU M1018 SER M1020 -1 O ILE M1019 N GLN M1010
SHEET 3 AO2 4 ILE M1027 ASN M1031 -1 O GLN M1028 N SER M1020
SHEET 4 AO2 4 LYS M1036 LEU M1040 -1 O LEU M1040 N ILE M1027
SHEET 1 AO3 4 ASP M1049 LEU M1052 0
SHEET 2 AO3 4 ARG M1057 TRP M1061 -1 O TRP M1061 N ASP M1049
SHEET 3 AO3 4 VAL M1067 ASN M1071 -1 O TRP M1070 N LEU M1058
SHEET 4 AO3 4 LYS M1079 PHE M1081 -1 O PHE M1081 N VAL M1067
SHEET 1 AO4 4 SER M1090 ILE M1093 0
SHEET 2 AO4 4 SER M1101 SER M1104 -1 O SER M1102 N ASP M1092
SHEET 3 AO4 4 ALA M1109 TRP M1112 -1 O TRP M1112 N SER M1101
SHEET 4 AO4 4 HIS M1121 LEU M1123 -1 O HIS M1121 N ILE M1111
SHEET 1 AO5 2 CYS M1132 PHE M1135 0
SHEET 2 AO5 2 LEU M1142 GLY M1145 -1 O GLY M1145 N CYS M1132
SHEET 1 AO6 3 ASP M1182 PHE M1185 0
SHEET 2 AO6 3 MET M1191 ALA M1195 -1 O ILE M1193 N CYS M1184
SHEET 3 AO6 3 ILE M1199 ASN M1203 -1 O TRP M1202 N LEU M1192
SHEET 1 AO7 2 VAL M1233 VAL M1235 0
SHEET 2 AO7 2 LEU M1241 ILE M1243 -1 O TYR M1242 N THR M1234
SSBOND 1 CYS A 633 CYS A 663 1555 1555 2.20
SSBOND 2 CYS A 675 CYS A 705 1555 1555 2.02
SSBOND 3 CYS A 704 CYS A 749 1555 1555 1.90
SSBOND 4 CYS A 761 CYS A 804 1555 1555 2.05
SSBOND 5 CYS A 803 CYS A 846 1555 1555 2.09
SSBOND 6 CYS C 633 CYS C 663 1555 1555 2.20
SSBOND 7 CYS C 675 CYS C 705 1555 1555 2.02
SSBOND 8 CYS C 704 CYS C 749 1555 1555 1.90
SSBOND 9 CYS C 761 CYS C 804 1555 1555 2.05
SSBOND 10 CYS C 803 CYS C 846 1555 1555 2.10
SSBOND 11 CYS E 633 CYS E 663 1555 1555 2.20
SSBOND 12 CYS E 675 CYS E 705 1555 1555 2.02
SSBOND 13 CYS E 704 CYS E 749 1555 1555 1.89
SSBOND 14 CYS E 761 CYS E 804 1555 1555 2.05
SSBOND 15 CYS E 803 CYS E 846 1555 1555 2.09
SSBOND 16 CYS G 633 CYS G 663 1555 1555 2.20
SSBOND 17 CYS G 675 CYS G 705 1555 1555 2.02
SSBOND 18 CYS G 704 CYS G 749 1555 1555 1.89
SSBOND 19 CYS G 761 CYS G 804 1555 1555 2.05
SSBOND 20 CYS G 803 CYS G 846 1555 1555 2.09
SSBOND 21 CYS I 633 CYS I 663 1555 1555 2.20
SSBOND 22 CYS I 675 CYS I 705 1555 1555 2.02
SSBOND 23 CYS I 704 CYS I 749 1555 1555 1.89
SSBOND 24 CYS I 761 CYS I 804 1555 1555 2.05
SSBOND 25 CYS I 803 CYS I 846 1555 1555 2.09
SSBOND 26 CYS K 633 CYS K 663 1555 1555 2.19
SSBOND 27 CYS K 675 CYS K 705 1555 1555 2.02
SSBOND 28 CYS K 704 CYS K 749 1555 1555 1.89
SSBOND 29 CYS K 761 CYS K 804 1555 1555 2.05
SSBOND 30 CYS K 803 CYS K 846 1555 1555 2.09
SSBOND 31 CYS M 633 CYS M 663 1555 1555 2.20
SSBOND 32 CYS M 675 CYS M 705 1555 1555 2.02
SSBOND 33 CYS M 704 CYS M 749 1555 1555 1.89
SSBOND 34 CYS M 761 CYS M 804 1555 1555 2.05
SSBOND 35 CYS M 803 CYS M 846 1555 1555 2.10
LINK OG SER A 141 CD1 LEU W 10 1555 1555 1.49
LINK OG SER A 161 MG MG A1302 1555 1555 2.43
LINK NE2 HIS B 18 FE HEM B 201 1555 1555 2.37
LINK SD MET B 80 FE HEM B 201 1555 1555 2.44
LINK OG SER C 161 MG MG C1302 1555 1555 2.43
LINK NE2 HIS D 18 FE HEM D 201 1555 1555 2.37
LINK SD MET D 80 FE HEM D 201 1555 1555 2.44
LINK OG SER E 161 MG MG E1302 1555 1555 2.43
LINK NE2 HIS F 18 FE HEM F 201 1555 1555 2.37
LINK SD MET F 80 FE HEM F 201 1555 1555 2.44
LINK OG SER G 161 MG MG G1302 1555 1555 2.43
LINK NE2 HIS H 18 FE HEM H 201 1555 1555 2.37
LINK SD MET H 80 FE HEM H 201 1555 1555 2.44
LINK OG SER I 161 MG MG I1302 1555 1555 2.43
LINK NE2 HIS J 18 FE HEM J 201 1555 1555 2.37
LINK SD MET J 80 FE HEM J 201 1555 1555 2.44
LINK OG SER K 161 MG MG K1302 1555 1555 2.44
LINK NE2 HIS L 18 FE HEM L 201 1555 1555 2.37
LINK SD MET L 80 FE HEM L 201 1555 1555 2.44
LINK OG SER M 161 MG MG M1302 1555 1555 2.43
LINK NE2 HIS N 18 FE HEM N 201 1555 1555 2.37
LINK SD MET N 80 FE HEM N 201 1555 1555 2.44
LINK O3G DTP A1301 MG MG A1302 1555 1555 2.44
LINK O2B DTP A1301 MG MG A1302 1555 1555 2.17
LINK O3G DTP C1301 MG MG C1302 1555 1555 2.44
LINK O2B DTP C1301 MG MG C1302 1555 1555 2.17
LINK O3G DTP E1301 MG MG E1302 1555 1555 2.44
LINK O2B DTP E1301 MG MG E1302 1555 1555 2.17
LINK O3G DTP G1301 MG MG G1302 1555 1555 2.43
LINK O2B DTP G1301 MG MG G1302 1555 1555 2.17
LINK O3G DTP I1301 MG MG I1302 1555 1555 2.43
LINK O2B DTP I1301 MG MG I1302 1555 1555 2.17
LINK O3G DTP K1301 MG MG K1302 1555 1555 2.43
LINK O2B DTP K1301 MG MG K1302 1555 1555 2.17
LINK O3G DTP M1301 MG MG M1302 1555 1555 2.43
LINK O2B DTP M1301 MG MG M1302 1555 1555 2.17
SITE 1 AC1 13 VAL A 125 PHE A 126 VAL A 127 GLY A 159
SITE 2 AC1 13 LYS A 160 SER A 161 VAL A 162 ASP A 244
SITE 3 AC1 13 ARG A 265 PRO A 321 SER A 325 TYR A 359
SITE 4 AC1 13 MG A1302
SITE 1 AC2 3 SER A 161 ASP A 243 DTP A1301
SITE 1 AC3 22 LYS B 13 CYS B 14 CYS B 17 HIS B 18
SITE 2 AC3 22 THR B 28 GLY B 29 PRO B 30 LEU B 32
SITE 3 AC3 22 ARG B 38 THR B 40 GLY B 41 TYR B 48
SITE 4 AC3 22 THR B 49 ASN B 52 TRP B 59 TYR B 67
SITE 5 AC3 22 THR B 78 LYS B 79 MET B 80 ILE B 81
SITE 6 AC3 22 PHE B 82 LEU B 94
SITE 1 AC4 13 VAL C 125 PHE C 126 VAL C 127 GLY C 159
SITE 2 AC4 13 LYS C 160 SER C 161 VAL C 162 ASP C 244
SITE 3 AC4 13 ARG C 265 PRO C 321 SER C 325 TYR C 359
SITE 4 AC4 13 MG C1302
SITE 1 AC5 3 SER C 161 ASP C 243 DTP C1301
SITE 1 AC6 22 LYS D 13 CYS D 14 CYS D 17 HIS D 18
SITE 2 AC6 22 THR D 28 GLY D 29 PRO D 30 LEU D 32
SITE 3 AC6 22 ARG D 38 THR D 40 GLY D 41 TYR D 48
SITE 4 AC6 22 THR D 49 ASN D 52 TRP D 59 TYR D 67
SITE 5 AC6 22 THR D 78 LYS D 79 MET D 80 ILE D 81
SITE 6 AC6 22 PHE D 82 LEU D 94
SITE 1 AC7 13 VAL E 125 PHE E 126 VAL E 127 GLY E 159
SITE 2 AC7 13 LYS E 160 SER E 161 VAL E 162 ASP E 244
SITE 3 AC7 13 ARG E 265 PRO E 321 SER E 325 TYR E 359
SITE 4 AC7 13 MG E1302
SITE 1 AC8 3 SER E 161 ASP E 243 DTP E1301
SITE 1 AC9 22 LYS F 13 CYS F 14 CYS F 17 HIS F 18
SITE 2 AC9 22 THR F 28 GLY F 29 PRO F 30 LEU F 32
SITE 3 AC9 22 ARG F 38 THR F 40 GLY F 41 TYR F 48
SITE 4 AC9 22 THR F 49 ASN F 52 TRP F 59 TYR F 67
SITE 5 AC9 22 THR F 78 LYS F 79 MET F 80 ILE F 81
SITE 6 AC9 22 PHE F 82 LEU F 94
SITE 1 AD1 13 VAL G 125 PHE G 126 VAL G 127 GLY G 159
SITE 2 AD1 13 LYS G 160 SER G 161 VAL G 162 ASP G 244
SITE 3 AD1 13 ARG G 265 PRO G 321 SER G 325 TYR G 359
SITE 4 AD1 13 MG G1302
SITE 1 AD2 3 SER G 161 ASP G 243 DTP G1301
SITE 1 AD3 22 LYS H 13 CYS H 14 CYS H 17 HIS H 18
SITE 2 AD3 22 THR H 28 GLY H 29 PRO H 30 LEU H 32
SITE 3 AD3 22 ARG H 38 THR H 40 GLY H 41 TYR H 48
SITE 4 AD3 22 THR H 49 ASN H 52 TRP H 59 TYR H 67
SITE 5 AD3 22 THR H 78 LYS H 79 MET H 80 ILE H 81
SITE 6 AD3 22 PHE H 82 LEU H 94
SITE 1 AD4 13 VAL I 125 PHE I 126 VAL I 127 GLY I 159
SITE 2 AD4 13 LYS I 160 SER I 161 VAL I 162 ASP I 244
SITE 3 AD4 13 ARG I 265 PRO I 321 SER I 325 TYR I 359
SITE 4 AD4 13 MG I1302
SITE 1 AD5 3 SER I 161 ASP I 243 DTP I1301
SITE 1 AD6 22 LYS J 13 CYS J 14 CYS J 17 HIS J 18
SITE 2 AD6 22 THR J 28 GLY J 29 PRO J 30 LEU J 32
SITE 3 AD6 22 ARG J 38 THR J 40 GLY J 41 TYR J 48
SITE 4 AD6 22 THR J 49 ASN J 52 TRP J 59 TYR J 67
SITE 5 AD6 22 THR J 78 LYS J 79 MET J 80 ILE J 81
SITE 6 AD6 22 PHE J 82 LEU J 94
SITE 1 AD7 13 VAL K 125 PHE K 126 VAL K 127 GLY K 159
SITE 2 AD7 13 LYS K 160 SER K 161 VAL K 162 ASP K 244
SITE 3 AD7 13 ARG K 265 PRO K 321 SER K 325 TYR K 359
SITE 4 AD7 13 MG K1302
SITE 1 AD8 3 SER K 161 ASP K 243 DTP K1301
SITE 1 AD9 22 LYS L 13 CYS L 14 CYS L 17 HIS L 18
SITE 2 AD9 22 THR L 28 GLY L 29 PRO L 30 LEU L 32
SITE 3 AD9 22 ARG L 38 THR L 40 GLY L 41 TYR L 48
SITE 4 AD9 22 THR L 49 ASN L 52 TRP L 59 TYR L 67
SITE 5 AD9 22 THR L 78 LYS L 79 MET L 80 ILE L 81
SITE 6 AD9 22 PHE L 82 LEU L 94
SITE 1 AE1 13 VAL M 125 PHE M 126 VAL M 127 GLY M 159
SITE 2 AE1 13 LYS M 160 SER M 161 VAL M 162 ASP M 244
SITE 3 AE1 13 ARG M 265 PRO M 321 SER M 325 TYR M 359
SITE 4 AE1 13 MG M1302
SITE 1 AE2 3 SER M 161 ASP M 243 DTP M1301
SITE 1 AE3 22 LYS N 13 CYS N 14 CYS N 17 HIS N 18
SITE 2 AE3 22 THR N 28 GLY N 29 PRO N 30 LEU N 32
SITE 3 AE3 22 ARG N 38 THR N 40 GLY N 41 TYR N 48
SITE 4 AE3 22 THR N 49 ASN N 52 TRP N 59 TYR N 67
SITE 5 AE3 22 THR N 78 LYS N 79 MET N 80 ILE N 81
SITE 6 AE3 22 PHE N 82 LEU N 94
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
