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Database: PDB
Entry: 5WVE
LinkDB: 5WVE
Original site: 5WVE 
HEADER    APOPTOSIS                               24-DEC-16   5WVE              
TITLE     APAF-1-CASPASE-9 HOLOENZYME                                           
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: APOPTOTIC PROTEASE-ACTIVATING FACTOR 1;                    
COMPND   3 CHAIN: A, C, E, G, I, K, M;                                          
COMPND   4 SYNONYM: APAF-1;                                                     
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: CYTOCHROME C;                                              
COMPND   8 CHAIN: B, D, F, H, J, L, N;                                          
COMPND   9 ENGINEERED: YES;                                                     
COMPND  10 MOL_ID: 3;                                                           
COMPND  11 MOLECULE: APOPTOTIC PROTEASE-ACTIVATING FACTOR 1;                    
COMPND  12 CHAIN: O, P, Q, R, W, X;                                             
COMPND  13 FRAGMENT: CARD DOMAIN, UNP RESIDUES 1-102;                           
COMPND  14 SYNONYM: APAF-1;                                                     
COMPND  15 ENGINEERED: YES;                                                     
COMPND  16 MOL_ID: 4;                                                           
COMPND  17 MOLECULE: CASPASE;                                                   
COMPND  18 CHAIN: S, T, U, V, Y;                                                
COMPND  19 FRAGMENT: CARD DOMAIN, UNP RESIDUES 1-100;                           
COMPND  20 SYNONYM: CASPASE-9;                                                  
COMPND  21 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: APAF1, KIAA0413;                                               
SOURCE   6 EXPRESSION_SYSTEM: INSECT CELL EXPRESSION VECTOR PTIE1;              
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 266783;                                     
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: EQUUS CABALLUS;                                 
SOURCE  10 ORGANISM_COMMON: HORSE;                                              
SOURCE  11 ORGANISM_TAXID: 9796;                                                
SOURCE  12 GENE: CYCS, CYC;                                                     
SOURCE  13 EXPRESSION_SYSTEM: BACTERIA;                                         
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 2;                                          
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 GENE: APAF1, KIAA0413;                                               
SOURCE  20 EXPRESSION_SYSTEM: INSECT CELL EXPRESSION VECTOR PTIE1;              
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 266783;                                     
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  24 ORGANISM_COMMON: HUMAN;                                              
SOURCE  25 ORGANISM_TAXID: 9606;                                                
SOURCE  26 EXPRESSION_SYSTEM: BACTERIA;                                         
SOURCE  27 EXPRESSION_SYSTEM_TAXID: 2                                           
KEYWDS    APOPTOSIS HOLOENZYME, APOPTOSIS                                       
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    Y.LI,M.ZHOU,Q.HU,Y.SHI                                                
REVDAT   2   01-MAR-17 5WVE    1       JRNL                                     
REVDAT   1   08-FEB-17 5WVE    0                                                
JRNL        AUTH   Y.LI,M.ZHOU,Q.HU,X.-C.BAI,W.HUANG,S.H.W.SCHERES,Y.SHI        
JRNL        TITL   MECHANISTIC INSIGHTS INTO CASPASE-9 ACTIVATION BY THE        
JRNL        TITL 2 STRUCTURE OF THE APOPTOSOME HOLOENZYME                       
JRNL        REF    PROC. NATL. ACAD. SCI.        V. 114  1542 2017              
JRNL        REF  2 U.S.A.                                                       
JRNL        REFN                   ESSN 1091-6490                               
JRNL        PMID   28143931                                                     
JRNL        DOI    10.1073/PNAS.1620626114                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.40 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.400                          
REMARK   3   NUMBER OF PARTICLES               : 240130                         
REMARK   3   CTF CORRECTION METHOD             : NONE                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5WVE COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 05-JAN-17.                  
REMARK 100 THE DEPOSITION ID IS D_1300002450.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : APAF-1 APOPTOSOME; APAF-1;        
REMARK 245                                    CYTOCHROME C; APAF-1 CARD;        
REMARK 245                                    CASPASE-9 CARD                    
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI POLARA 300                 
REMARK 245   DETECTOR TYPE                     : FEI FALCON II (4K X 4K)        
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 32.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 25-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N, O, P, Q, R, S,            
REMARK 350                    AND CHAINS: T, U, V, W, X, Y                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ASP A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     LYS A     4                                                      
REMARK 465     ALA A     5                                                      
REMARK 465     ARG A     6                                                      
REMARK 465     ASN A     7                                                      
REMARK 465     CYS A     8                                                      
REMARK 465     LEU A     9                                                      
REMARK 465     LEU A    10                                                      
REMARK 465     GLN A    11                                                      
REMARK 465     HIS A    12                                                      
REMARK 465     ARG A    13                                                      
REMARK 465     GLU A    14                                                      
REMARK 465     ALA A    15                                                      
REMARK 465     LEU A    16                                                      
REMARK 465     GLU A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     ASP A    19                                                      
REMARK 465     ILE A    20                                                      
REMARK 465     LYS A    21                                                      
REMARK 465     THR A    22                                                      
REMARK 465     SER A    23                                                      
REMARK 465     TYR A    24                                                      
REMARK 465     ILE A    25                                                      
REMARK 465     MET A    26                                                      
REMARK 465     ASP A    27                                                      
REMARK 465     HIS A    28                                                      
REMARK 465     MET A    29                                                      
REMARK 465     ILE A    30                                                      
REMARK 465     SER A    31                                                      
REMARK 465     ASP A    32                                                      
REMARK 465     GLY A    33                                                      
REMARK 465     PHE A    34                                                      
REMARK 465     LEU A    35                                                      
REMARK 465     THR A    36                                                      
REMARK 465     ILE A    37                                                      
REMARK 465     SER A    38                                                      
REMARK 465     GLU A    39                                                      
REMARK 465     GLU A    40                                                      
REMARK 465     GLU A    41                                                      
REMARK 465     LYS A    42                                                      
REMARK 465     VAL A    43                                                      
REMARK 465     ARG A    44                                                      
REMARK 465     ASN A    45                                                      
REMARK 465     GLU A    46                                                      
REMARK 465     PRO A    47                                                      
REMARK 465     THR A    48                                                      
REMARK 465     GLN A    49                                                      
REMARK 465     GLN A    50                                                      
REMARK 465     GLN A    51                                                      
REMARK 465     ARG A    52                                                      
REMARK 465     ALA A    53                                                      
REMARK 465     ALA A    54                                                      
REMARK 465     MET A    55                                                      
REMARK 465     LEU A    56                                                      
REMARK 465     ILE A    57                                                      
REMARK 465     LYS A    58                                                      
REMARK 465     MET A    59                                                      
REMARK 465     ILE A    60                                                      
REMARK 465     LEU A    61                                                      
REMARK 465     LYS A    62                                                      
REMARK 465     LYS A    63                                                      
REMARK 465     ASP A    64                                                      
REMARK 465     ASN A    65                                                      
REMARK 465     ASP A    66                                                      
REMARK 465     SER A    67                                                      
REMARK 465     TYR A    68                                                      
REMARK 465     VAL A    69                                                      
REMARK 465     SER A    70                                                      
REMARK 465     PHE A    71                                                      
REMARK 465     TYR A    72                                                      
REMARK 465     ASN A    73                                                      
REMARK 465     ALA A    74                                                      
REMARK 465     LEU A    75                                                      
REMARK 465     LEU A    76                                                      
REMARK 465     HIS A    77                                                      
REMARK 465     GLU A    78                                                      
REMARK 465     GLY A    79                                                      
REMARK 465     TYR A    80                                                      
REMARK 465     LYS A    81                                                      
REMARK 465     ASP A    82                                                      
REMARK 465     LEU A    83                                                      
REMARK 465     ALA A    84                                                      
REMARK 465     ALA A    85                                                      
REMARK 465     LEU A    86                                                      
REMARK 465     LEU A    87                                                      
REMARK 465     HIS A    88                                                      
REMARK 465     ASP A    89                                                      
REMARK 465     GLY A    90                                                      
REMARK 465     ILE A    91                                                      
REMARK 465     PRO A    92                                                      
REMARK 465     VAL A    93                                                      
REMARK 465     VAL A    94                                                      
REMARK 465     SER A    95                                                      
REMARK 465     SER A    96                                                      
REMARK 465     SER A    97                                                      
REMARK 465     SER A    98                                                      
REMARK 465     GLY A    99                                                      
REMARK 465     LYS A   100                                                      
REMARK 465     ASP A   101                                                      
REMARK 465     SER A   102                                                      
REMARK 465     VAL A   103                                                      
REMARK 465     SER A   104                                                      
REMARK 465     MET B     0                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ASP C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     LYS C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     ARG C     6                                                      
REMARK 465     ASN C     7                                                      
REMARK 465     CYS C     8                                                      
REMARK 465     LEU C     9                                                      
REMARK 465     LEU C    10                                                      
REMARK 465     GLN C    11                                                      
REMARK 465     HIS C    12                                                      
REMARK 465     ARG C    13                                                      
REMARK 465     GLU C    14                                                      
REMARK 465     ALA C    15                                                      
REMARK 465     LEU C    16                                                      
REMARK 465     GLU C    17                                                      
REMARK 465     LYS C    18                                                      
REMARK 465     ASP C    19                                                      
REMARK 465     ILE C    20                                                      
REMARK 465     LYS C    21                                                      
REMARK 465     THR C    22                                                      
REMARK 465     SER C    23                                                      
REMARK 465     TYR C    24                                                      
REMARK 465     ILE C    25                                                      
REMARK 465     MET C    26                                                      
REMARK 465     ASP C    27                                                      
REMARK 465     HIS C    28                                                      
REMARK 465     MET C    29                                                      
REMARK 465     ILE C    30                                                      
REMARK 465     SER C    31                                                      
REMARK 465     ASP C    32                                                      
REMARK 465     GLY C    33                                                      
REMARK 465     PHE C    34                                                      
REMARK 465     LEU C    35                                                      
REMARK 465     THR C    36                                                      
REMARK 465     ILE C    37                                                      
REMARK 465     SER C    38                                                      
REMARK 465     GLU C    39                                                      
REMARK 465     GLU C    40                                                      
REMARK 465     GLU C    41                                                      
REMARK 465     LYS C    42                                                      
REMARK 465     VAL C    43                                                      
REMARK 465     ARG C    44                                                      
REMARK 465     ASN C    45                                                      
REMARK 465     GLU C    46                                                      
REMARK 465     PRO C    47                                                      
REMARK 465     THR C    48                                                      
REMARK 465     GLN C    49                                                      
REMARK 465     GLN C    50                                                      
REMARK 465     GLN C    51                                                      
REMARK 465     ARG C    52                                                      
REMARK 465     ALA C    53                                                      
REMARK 465     ALA C    54                                                      
REMARK 465     MET C    55                                                      
REMARK 465     LEU C    56                                                      
REMARK 465     ILE C    57                                                      
REMARK 465     LYS C    58                                                      
REMARK 465     MET C    59                                                      
REMARK 465     ILE C    60                                                      
REMARK 465     LEU C    61                                                      
REMARK 465     LYS C    62                                                      
REMARK 465     LYS C    63                                                      
REMARK 465     ASP C    64                                                      
REMARK 465     ASN C    65                                                      
REMARK 465     ASP C    66                                                      
REMARK 465     SER C    67                                                      
REMARK 465     TYR C    68                                                      
REMARK 465     VAL C    69                                                      
REMARK 465     SER C    70                                                      
REMARK 465     PHE C    71                                                      
REMARK 465     TYR C    72                                                      
REMARK 465     ASN C    73                                                      
REMARK 465     ALA C    74                                                      
REMARK 465     LEU C    75                                                      
REMARK 465     LEU C    76                                                      
REMARK 465     HIS C    77                                                      
REMARK 465     GLU C    78                                                      
REMARK 465     GLY C    79                                                      
REMARK 465     TYR C    80                                                      
REMARK 465     LYS C    81                                                      
REMARK 465     ASP C    82                                                      
REMARK 465     LEU C    83                                                      
REMARK 465     ALA C    84                                                      
REMARK 465     ALA C    85                                                      
REMARK 465     LEU C    86                                                      
REMARK 465     LEU C    87                                                      
REMARK 465     HIS C    88                                                      
REMARK 465     ASP C    89                                                      
REMARK 465     GLY C    90                                                      
REMARK 465     ILE C    91                                                      
REMARK 465     PRO C    92                                                      
REMARK 465     VAL C    93                                                      
REMARK 465     VAL C    94                                                      
REMARK 465     SER C    95                                                      
REMARK 465     SER C    96                                                      
REMARK 465     SER C    97                                                      
REMARK 465     SER C    98                                                      
REMARK 465     GLY C    99                                                      
REMARK 465     LYS C   100                                                      
REMARK 465     ASP C   101                                                      
REMARK 465     SER C   102                                                      
REMARK 465     VAL C   103                                                      
REMARK 465     SER C   104                                                      
REMARK 465     MET D     0                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ASP E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     LYS E     4                                                      
REMARK 465     ALA E     5                                                      
REMARK 465     ARG E     6                                                      
REMARK 465     ASN E     7                                                      
REMARK 465     CYS E     8                                                      
REMARK 465     LEU E     9                                                      
REMARK 465     LEU E    10                                                      
REMARK 465     GLN E    11                                                      
REMARK 465     HIS E    12                                                      
REMARK 465     ARG E    13                                                      
REMARK 465     GLU E    14                                                      
REMARK 465     ALA E    15                                                      
REMARK 465     LEU E    16                                                      
REMARK 465     GLU E    17                                                      
REMARK 465     LYS E    18                                                      
REMARK 465     ASP E    19                                                      
REMARK 465     ILE E    20                                                      
REMARK 465     LYS E    21                                                      
REMARK 465     THR E    22                                                      
REMARK 465     SER E    23                                                      
REMARK 465     TYR E    24                                                      
REMARK 465     ILE E    25                                                      
REMARK 465     MET E    26                                                      
REMARK 465     ASP E    27                                                      
REMARK 465     HIS E    28                                                      
REMARK 465     MET E    29                                                      
REMARK 465     ILE E    30                                                      
REMARK 465     SER E    31                                                      
REMARK 465     ASP E    32                                                      
REMARK 465     GLY E    33                                                      
REMARK 465     PHE E    34                                                      
REMARK 465     LEU E    35                                                      
REMARK 465     THR E    36                                                      
REMARK 465     ILE E    37                                                      
REMARK 465     SER E    38                                                      
REMARK 465     GLU E    39                                                      
REMARK 465     GLU E    40                                                      
REMARK 465     GLU E    41                                                      
REMARK 465     LYS E    42                                                      
REMARK 465     VAL E    43                                                      
REMARK 465     ARG E    44                                                      
REMARK 465     ASN E    45                                                      
REMARK 465     GLU E    46                                                      
REMARK 465     PRO E    47                                                      
REMARK 465     THR E    48                                                      
REMARK 465     GLN E    49                                                      
REMARK 465     GLN E    50                                                      
REMARK 465     GLN E    51                                                      
REMARK 465     ARG E    52                                                      
REMARK 465     ALA E    53                                                      
REMARK 465     ALA E    54                                                      
REMARK 465     MET E    55                                                      
REMARK 465     LEU E    56                                                      
REMARK 465     ILE E    57                                                      
REMARK 465     LYS E    58                                                      
REMARK 465     MET E    59                                                      
REMARK 465     ILE E    60                                                      
REMARK 465     LEU E    61                                                      
REMARK 465     LYS E    62                                                      
REMARK 465     LYS E    63                                                      
REMARK 465     ASP E    64                                                      
REMARK 465     ASN E    65                                                      
REMARK 465     ASP E    66                                                      
REMARK 465     SER E    67                                                      
REMARK 465     TYR E    68                                                      
REMARK 465     VAL E    69                                                      
REMARK 465     SER E    70                                                      
REMARK 465     PHE E    71                                                      
REMARK 465     TYR E    72                                                      
REMARK 465     ASN E    73                                                      
REMARK 465     ALA E    74                                                      
REMARK 465     LEU E    75                                                      
REMARK 465     LEU E    76                                                      
REMARK 465     HIS E    77                                                      
REMARK 465     GLU E    78                                                      
REMARK 465     GLY E    79                                                      
REMARK 465     TYR E    80                                                      
REMARK 465     LYS E    81                                                      
REMARK 465     ASP E    82                                                      
REMARK 465     LEU E    83                                                      
REMARK 465     ALA E    84                                                      
REMARK 465     ALA E    85                                                      
REMARK 465     LEU E    86                                                      
REMARK 465     LEU E    87                                                      
REMARK 465     HIS E    88                                                      
REMARK 465     ASP E    89                                                      
REMARK 465     GLY E    90                                                      
REMARK 465     ILE E    91                                                      
REMARK 465     PRO E    92                                                      
REMARK 465     VAL E    93                                                      
REMARK 465     VAL E    94                                                      
REMARK 465     SER E    95                                                      
REMARK 465     SER E    96                                                      
REMARK 465     SER E    97                                                      
REMARK 465     SER E    98                                                      
REMARK 465     GLY E    99                                                      
REMARK 465     LYS E   100                                                      
REMARK 465     ASP E   101                                                      
REMARK 465     SER E   102                                                      
REMARK 465     VAL E   103                                                      
REMARK 465     SER E   104                                                      
REMARK 465     MET F     0                                                      
REMARK 465     MET G     1                                                      
REMARK 465     ASP G     2                                                      
REMARK 465     ALA G     3                                                      
REMARK 465     LYS G     4                                                      
REMARK 465     ALA G     5                                                      
REMARK 465     ARG G     6                                                      
REMARK 465     ASN G     7                                                      
REMARK 465     CYS G     8                                                      
REMARK 465     LEU G     9                                                      
REMARK 465     LEU G    10                                                      
REMARK 465     GLN G    11                                                      
REMARK 465     HIS G    12                                                      
REMARK 465     ARG G    13                                                      
REMARK 465     GLU G    14                                                      
REMARK 465     ALA G    15                                                      
REMARK 465     LEU G    16                                                      
REMARK 465     GLU G    17                                                      
REMARK 465     LYS G    18                                                      
REMARK 465     ASP G    19                                                      
REMARK 465     ILE G    20                                                      
REMARK 465     LYS G    21                                                      
REMARK 465     THR G    22                                                      
REMARK 465     SER G    23                                                      
REMARK 465     TYR G    24                                                      
REMARK 465     ILE G    25                                                      
REMARK 465     MET G    26                                                      
REMARK 465     ASP G    27                                                      
REMARK 465     HIS G    28                                                      
REMARK 465     MET G    29                                                      
REMARK 465     ILE G    30                                                      
REMARK 465     SER G    31                                                      
REMARK 465     ASP G    32                                                      
REMARK 465     GLY G    33                                                      
REMARK 465     PHE G    34                                                      
REMARK 465     LEU G    35                                                      
REMARK 465     THR G    36                                                      
REMARK 465     ILE G    37                                                      
REMARK 465     SER G    38                                                      
REMARK 465     GLU G    39                                                      
REMARK 465     GLU G    40                                                      
REMARK 465     GLU G    41                                                      
REMARK 465     LYS G    42                                                      
REMARK 465     VAL G    43                                                      
REMARK 465     ARG G    44                                                      
REMARK 465     ASN G    45                                                      
REMARK 465     GLU G    46                                                      
REMARK 465     PRO G    47                                                      
REMARK 465     THR G    48                                                      
REMARK 465     GLN G    49                                                      
REMARK 465     GLN G    50                                                      
REMARK 465     GLN G    51                                                      
REMARK 465     ARG G    52                                                      
REMARK 465     ALA G    53                                                      
REMARK 465     ALA G    54                                                      
REMARK 465     MET G    55                                                      
REMARK 465     LEU G    56                                                      
REMARK 465     ILE G    57                                                      
REMARK 465     LYS G    58                                                      
REMARK 465     MET G    59                                                      
REMARK 465     ILE G    60                                                      
REMARK 465     LEU G    61                                                      
REMARK 465     LYS G    62                                                      
REMARK 465     LYS G    63                                                      
REMARK 465     ASP G    64                                                      
REMARK 465     ASN G    65                                                      
REMARK 465     ASP G    66                                                      
REMARK 465     SER G    67                                                      
REMARK 465     TYR G    68                                                      
REMARK 465     VAL G    69                                                      
REMARK 465     SER G    70                                                      
REMARK 465     PHE G    71                                                      
REMARK 465     TYR G    72                                                      
REMARK 465     ASN G    73                                                      
REMARK 465     ALA G    74                                                      
REMARK 465     LEU G    75                                                      
REMARK 465     LEU G    76                                                      
REMARK 465     HIS G    77                                                      
REMARK 465     GLU G    78                                                      
REMARK 465     GLY G    79                                                      
REMARK 465     TYR G    80                                                      
REMARK 465     LYS G    81                                                      
REMARK 465     ASP G    82                                                      
REMARK 465     LEU G    83                                                      
REMARK 465     ALA G    84                                                      
REMARK 465     ALA G    85                                                      
REMARK 465     LEU G    86                                                      
REMARK 465     LEU G    87                                                      
REMARK 465     HIS G    88                                                      
REMARK 465     ASP G    89                                                      
REMARK 465     GLY G    90                                                      
REMARK 465     ILE G    91                                                      
REMARK 465     PRO G    92                                                      
REMARK 465     VAL G    93                                                      
REMARK 465     VAL G    94                                                      
REMARK 465     SER G    95                                                      
REMARK 465     SER G    96                                                      
REMARK 465     SER G    97                                                      
REMARK 465     SER G    98                                                      
REMARK 465     GLY G    99                                                      
REMARK 465     LYS G   100                                                      
REMARK 465     ASP G   101                                                      
REMARK 465     SER G   102                                                      
REMARK 465     VAL G   103                                                      
REMARK 465     SER G   104                                                      
REMARK 465     MET H     0                                                      
REMARK 465     MET I     1                                                      
REMARK 465     ASP I     2                                                      
REMARK 465     ALA I     3                                                      
REMARK 465     LYS I     4                                                      
REMARK 465     ALA I     5                                                      
REMARK 465     ARG I     6                                                      
REMARK 465     ASN I     7                                                      
REMARK 465     CYS I     8                                                      
REMARK 465     LEU I     9                                                      
REMARK 465     LEU I    10                                                      
REMARK 465     GLN I    11                                                      
REMARK 465     HIS I    12                                                      
REMARK 465     ARG I    13                                                      
REMARK 465     GLU I    14                                                      
REMARK 465     ALA I    15                                                      
REMARK 465     LEU I    16                                                      
REMARK 465     GLU I    17                                                      
REMARK 465     LYS I    18                                                      
REMARK 465     ASP I    19                                                      
REMARK 465     ILE I    20                                                      
REMARK 465     LYS I    21                                                      
REMARK 465     THR I    22                                                      
REMARK 465     SER I    23                                                      
REMARK 465     TYR I    24                                                      
REMARK 465     ILE I    25                                                      
REMARK 465     MET I    26                                                      
REMARK 465     ASP I    27                                                      
REMARK 465     HIS I    28                                                      
REMARK 465     MET I    29                                                      
REMARK 465     ILE I    30                                                      
REMARK 465     SER I    31                                                      
REMARK 465     ASP I    32                                                      
REMARK 465     GLY I    33                                                      
REMARK 465     PHE I    34                                                      
REMARK 465     LEU I    35                                                      
REMARK 465     THR I    36                                                      
REMARK 465     ILE I    37                                                      
REMARK 465     SER I    38                                                      
REMARK 465     GLU I    39                                                      
REMARK 465     GLU I    40                                                      
REMARK 465     GLU I    41                                                      
REMARK 465     LYS I    42                                                      
REMARK 465     VAL I    43                                                      
REMARK 465     ARG I    44                                                      
REMARK 465     ASN I    45                                                      
REMARK 465     GLU I    46                                                      
REMARK 465     PRO I    47                                                      
REMARK 465     THR I    48                                                      
REMARK 465     GLN I    49                                                      
REMARK 465     GLN I    50                                                      
REMARK 465     GLN I    51                                                      
REMARK 465     ARG I    52                                                      
REMARK 465     ALA I    53                                                      
REMARK 465     ALA I    54                                                      
REMARK 465     MET I    55                                                      
REMARK 465     LEU I    56                                                      
REMARK 465     ILE I    57                                                      
REMARK 465     LYS I    58                                                      
REMARK 465     MET I    59                                                      
REMARK 465     ILE I    60                                                      
REMARK 465     LEU I    61                                                      
REMARK 465     LYS I    62                                                      
REMARK 465     LYS I    63                                                      
REMARK 465     ASP I    64                                                      
REMARK 465     ASN I    65                                                      
REMARK 465     ASP I    66                                                      
REMARK 465     SER I    67                                                      
REMARK 465     TYR I    68                                                      
REMARK 465     VAL I    69                                                      
REMARK 465     SER I    70                                                      
REMARK 465     PHE I    71                                                      
REMARK 465     TYR I    72                                                      
REMARK 465     ASN I    73                                                      
REMARK 465     ALA I    74                                                      
REMARK 465     LEU I    75                                                      
REMARK 465     LEU I    76                                                      
REMARK 465     HIS I    77                                                      
REMARK 465     GLU I    78                                                      
REMARK 465     GLY I    79                                                      
REMARK 465     TYR I    80                                                      
REMARK 465     LYS I    81                                                      
REMARK 465     ASP I    82                                                      
REMARK 465     LEU I    83                                                      
REMARK 465     ALA I    84                                                      
REMARK 465     ALA I    85                                                      
REMARK 465     LEU I    86                                                      
REMARK 465     LEU I    87                                                      
REMARK 465     HIS I    88                                                      
REMARK 465     ASP I    89                                                      
REMARK 465     GLY I    90                                                      
REMARK 465     ILE I    91                                                      
REMARK 465     PRO I    92                                                      
REMARK 465     VAL I    93                                                      
REMARK 465     VAL I    94                                                      
REMARK 465     SER I    95                                                      
REMARK 465     SER I    96                                                      
REMARK 465     SER I    97                                                      
REMARK 465     SER I    98                                                      
REMARK 465     GLY I    99                                                      
REMARK 465     LYS I   100                                                      
REMARK 465     ASP I   101                                                      
REMARK 465     SER I   102                                                      
REMARK 465     VAL I   103                                                      
REMARK 465     SER I   104                                                      
REMARK 465     MET J     0                                                      
REMARK 465     MET K     1                                                      
REMARK 465     ASP K     2                                                      
REMARK 465     ALA K     3                                                      
REMARK 465     LYS K     4                                                      
REMARK 465     ALA K     5                                                      
REMARK 465     ARG K     6                                                      
REMARK 465     ASN K     7                                                      
REMARK 465     CYS K     8                                                      
REMARK 465     LEU K     9                                                      
REMARK 465     LEU K    10                                                      
REMARK 465     GLN K    11                                                      
REMARK 465     HIS K    12                                                      
REMARK 465     ARG K    13                                                      
REMARK 465     GLU K    14                                                      
REMARK 465     ALA K    15                                                      
REMARK 465     LEU K    16                                                      
REMARK 465     GLU K    17                                                      
REMARK 465     LYS K    18                                                      
REMARK 465     ASP K    19                                                      
REMARK 465     ILE K    20                                                      
REMARK 465     LYS K    21                                                      
REMARK 465     THR K    22                                                      
REMARK 465     SER K    23                                                      
REMARK 465     TYR K    24                                                      
REMARK 465     ILE K    25                                                      
REMARK 465     MET K    26                                                      
REMARK 465     ASP K    27                                                      
REMARK 465     HIS K    28                                                      
REMARK 465     MET K    29                                                      
REMARK 465     ILE K    30                                                      
REMARK 465     SER K    31                                                      
REMARK 465     ASP K    32                                                      
REMARK 465     GLY K    33                                                      
REMARK 465     PHE K    34                                                      
REMARK 465     LEU K    35                                                      
REMARK 465     THR K    36                                                      
REMARK 465     ILE K    37                                                      
REMARK 465     SER K    38                                                      
REMARK 465     GLU K    39                                                      
REMARK 465     GLU K    40                                                      
REMARK 465     GLU K    41                                                      
REMARK 465     LYS K    42                                                      
REMARK 465     VAL K    43                                                      
REMARK 465     ARG K    44                                                      
REMARK 465     ASN K    45                                                      
REMARK 465     GLU K    46                                                      
REMARK 465     PRO K    47                                                      
REMARK 465     THR K    48                                                      
REMARK 465     GLN K    49                                                      
REMARK 465     GLN K    50                                                      
REMARK 465     GLN K    51                                                      
REMARK 465     ARG K    52                                                      
REMARK 465     ALA K    53                                                      
REMARK 465     ALA K    54                                                      
REMARK 465     MET K    55                                                      
REMARK 465     LEU K    56                                                      
REMARK 465     ILE K    57                                                      
REMARK 465     LYS K    58                                                      
REMARK 465     MET K    59                                                      
REMARK 465     ILE K    60                                                      
REMARK 465     LEU K    61                                                      
REMARK 465     LYS K    62                                                      
REMARK 465     LYS K    63                                                      
REMARK 465     ASP K    64                                                      
REMARK 465     ASN K    65                                                      
REMARK 465     ASP K    66                                                      
REMARK 465     SER K    67                                                      
REMARK 465     TYR K    68                                                      
REMARK 465     VAL K    69                                                      
REMARK 465     SER K    70                                                      
REMARK 465     PHE K    71                                                      
REMARK 465     TYR K    72                                                      
REMARK 465     ASN K    73                                                      
REMARK 465     ALA K    74                                                      
REMARK 465     LEU K    75                                                      
REMARK 465     LEU K    76                                                      
REMARK 465     HIS K    77                                                      
REMARK 465     GLU K    78                                                      
REMARK 465     GLY K    79                                                      
REMARK 465     TYR K    80                                                      
REMARK 465     LYS K    81                                                      
REMARK 465     ASP K    82                                                      
REMARK 465     LEU K    83                                                      
REMARK 465     ALA K    84                                                      
REMARK 465     ALA K    85                                                      
REMARK 465     LEU K    86                                                      
REMARK 465     LEU K    87                                                      
REMARK 465     HIS K    88                                                      
REMARK 465     ASP K    89                                                      
REMARK 465     GLY K    90                                                      
REMARK 465     ILE K    91                                                      
REMARK 465     PRO K    92                                                      
REMARK 465     VAL K    93                                                      
REMARK 465     VAL K    94                                                      
REMARK 465     SER K    95                                                      
REMARK 465     SER K    96                                                      
REMARK 465     SER K    97                                                      
REMARK 465     SER K    98                                                      
REMARK 465     GLY K    99                                                      
REMARK 465     LYS K   100                                                      
REMARK 465     ASP K   101                                                      
REMARK 465     SER K   102                                                      
REMARK 465     VAL K   103                                                      
REMARK 465     SER K   104                                                      
REMARK 465     MET L     0                                                      
REMARK 465     MET M     1                                                      
REMARK 465     ASP M     2                                                      
REMARK 465     ALA M     3                                                      
REMARK 465     LYS M     4                                                      
REMARK 465     ALA M     5                                                      
REMARK 465     ARG M     6                                                      
REMARK 465     ASN M     7                                                      
REMARK 465     CYS M     8                                                      
REMARK 465     LEU M     9                                                      
REMARK 465     LEU M    10                                                      
REMARK 465     GLN M    11                                                      
REMARK 465     HIS M    12                                                      
REMARK 465     ARG M    13                                                      
REMARK 465     GLU M    14                                                      
REMARK 465     ALA M    15                                                      
REMARK 465     LEU M    16                                                      
REMARK 465     GLU M    17                                                      
REMARK 465     LYS M    18                                                      
REMARK 465     ASP M    19                                                      
REMARK 465     ILE M    20                                                      
REMARK 465     LYS M    21                                                      
REMARK 465     THR M    22                                                      
REMARK 465     SER M    23                                                      
REMARK 465     TYR M    24                                                      
REMARK 465     ILE M    25                                                      
REMARK 465     MET M    26                                                      
REMARK 465     ASP M    27                                                      
REMARK 465     HIS M    28                                                      
REMARK 465     MET M    29                                                      
REMARK 465     ILE M    30                                                      
REMARK 465     SER M    31                                                      
REMARK 465     ASP M    32                                                      
REMARK 465     GLY M    33                                                      
REMARK 465     PHE M    34                                                      
REMARK 465     LEU M    35                                                      
REMARK 465     THR M    36                                                      
REMARK 465     ILE M    37                                                      
REMARK 465     SER M    38                                                      
REMARK 465     GLU M    39                                                      
REMARK 465     GLU M    40                                                      
REMARK 465     GLU M    41                                                      
REMARK 465     LYS M    42                                                      
REMARK 465     VAL M    43                                                      
REMARK 465     ARG M    44                                                      
REMARK 465     ASN M    45                                                      
REMARK 465     GLU M    46                                                      
REMARK 465     PRO M    47                                                      
REMARK 465     THR M    48                                                      
REMARK 465     GLN M    49                                                      
REMARK 465     GLN M    50                                                      
REMARK 465     GLN M    51                                                      
REMARK 465     ARG M    52                                                      
REMARK 465     ALA M    53                                                      
REMARK 465     ALA M    54                                                      
REMARK 465     MET M    55                                                      
REMARK 465     LEU M    56                                                      
REMARK 465     ILE M    57                                                      
REMARK 465     LYS M    58                                                      
REMARK 465     MET M    59                                                      
REMARK 465     ILE M    60                                                      
REMARK 465     LEU M    61                                                      
REMARK 465     LYS M    62                                                      
REMARK 465     LYS M    63                                                      
REMARK 465     ASP M    64                                                      
REMARK 465     ASN M    65                                                      
REMARK 465     ASP M    66                                                      
REMARK 465     SER M    67                                                      
REMARK 465     TYR M    68                                                      
REMARK 465     VAL M    69                                                      
REMARK 465     SER M    70                                                      
REMARK 465     PHE M    71                                                      
REMARK 465     TYR M    72                                                      
REMARK 465     ASN M    73                                                      
REMARK 465     ALA M    74                                                      
REMARK 465     LEU M    75                                                      
REMARK 465     LEU M    76                                                      
REMARK 465     HIS M    77                                                      
REMARK 465     GLU M    78                                                      
REMARK 465     GLY M    79                                                      
REMARK 465     TYR M    80                                                      
REMARK 465     LYS M    81                                                      
REMARK 465     ASP M    82                                                      
REMARK 465     LEU M    83                                                      
REMARK 465     ALA M    84                                                      
REMARK 465     ALA M    85                                                      
REMARK 465     LEU M    86                                                      
REMARK 465     LEU M    87                                                      
REMARK 465     HIS M    88                                                      
REMARK 465     ASP M    89                                                      
REMARK 465     GLY M    90                                                      
REMARK 465     ILE M    91                                                      
REMARK 465     PRO M    92                                                      
REMARK 465     VAL M    93                                                      
REMARK 465     VAL M    94                                                      
REMARK 465     SER M    95                                                      
REMARK 465     SER M    96                                                      
REMARK 465     SER M    97                                                      
REMARK 465     SER M    98                                                      
REMARK 465     GLY M    99                                                      
REMARK 465     LYS M   100                                                      
REMARK 465     ASP M   101                                                      
REMARK 465     SER M   102                                                      
REMARK 465     VAL M   103                                                      
REMARK 465     SER M   104                                                      
REMARK 465     MET N     0                                                      
REMARK 465     PRO O    92                                                      
REMARK 465     VAL O    93                                                      
REMARK 465     VAL O    94                                                      
REMARK 465     SER O    95                                                      
REMARK 465     SER O    96                                                      
REMARK 465     SER O    97                                                      
REMARK 465     SER O    98                                                      
REMARK 465     GLY O    99                                                      
REMARK 465     LYS O   100                                                      
REMARK 465     ASP O   101                                                      
REMARK 465     SER O   102                                                      
REMARK 465     PRO P    92                                                      
REMARK 465     VAL P    93                                                      
REMARK 465     VAL P    94                                                      
REMARK 465     SER P    95                                                      
REMARK 465     SER P    96                                                      
REMARK 465     SER P    97                                                      
REMARK 465     SER P    98                                                      
REMARK 465     GLY P    99                                                      
REMARK 465     LYS P   100                                                      
REMARK 465     ASP P   101                                                      
REMARK 465     SER P   102                                                      
REMARK 465     PRO Q    92                                                      
REMARK 465     VAL Q    93                                                      
REMARK 465     VAL Q    94                                                      
REMARK 465     SER Q    95                                                      
REMARK 465     SER Q    96                                                      
REMARK 465     SER Q    97                                                      
REMARK 465     SER Q    98                                                      
REMARK 465     GLY Q    99                                                      
REMARK 465     LYS Q   100                                                      
REMARK 465     ASP Q   101                                                      
REMARK 465     SER Q   102                                                      
REMARK 465     PRO R    92                                                      
REMARK 465     VAL R    93                                                      
REMARK 465     VAL R    94                                                      
REMARK 465     SER R    95                                                      
REMARK 465     SER R    96                                                      
REMARK 465     SER R    97                                                      
REMARK 465     SER R    98                                                      
REMARK 465     GLY R    99                                                      
REMARK 465     LYS R   100                                                      
REMARK 465     ASP R   101                                                      
REMARK 465     SER R   102                                                      
REMARK 465     LYS S    97                                                      
REMARK 465     LEU S    98                                                      
REMARK 465     SER S    99                                                      
REMARK 465     LYS S   100                                                      
REMARK 465     LYS T    97                                                      
REMARK 465     LEU T    98                                                      
REMARK 465     SER T    99                                                      
REMARK 465     LYS T   100                                                      
REMARK 465     LYS U    97                                                      
REMARK 465     LEU U    98                                                      
REMARK 465     SER U    99                                                      
REMARK 465     LYS U   100                                                      
REMARK 465     LYS V    97                                                      
REMARK 465     LEU V    98                                                      
REMARK 465     SER V    99                                                      
REMARK 465     LYS V   100                                                      
REMARK 465     SER W    96                                                      
REMARK 465     SER W    97                                                      
REMARK 465     SER W    98                                                      
REMARK 465     GLY W    99                                                      
REMARK 465     LYS W   100                                                      
REMARK 465     ASP W   101                                                      
REMARK 465     SER W   102                                                      
REMARK 465     VAL X    93                                                      
REMARK 465     VAL X    94                                                      
REMARK 465     SER X    95                                                      
REMARK 465     SER X    96                                                      
REMARK 465     SER X    97                                                      
REMARK 465     SER X    98                                                      
REMARK 465     GLY X    99                                                      
REMARK 465     LYS X   100                                                      
REMARK 465     ASP X   101                                                      
REMARK 465     SER X   102                                                      
REMARK 465     ALA Y    96                                                      
REMARK 465     LYS Y    97                                                      
REMARK 465     LEU Y    98                                                      
REMARK 465     SER Y    99                                                      
REMARK 465     LYS Y   100                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ALA S  96    CB                                                  
REMARK 470     ALA T  96    CB                                                  
REMARK 470     ALA U  96    CB                                                  
REMARK 470     ALA V  96    CB                                                  
REMARK 470     VAL Y  28    CG1  CG2                                            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    TRP E   483     CB   LEU E   487              1.82            
REMARK 500   O    TRP C   483     CB   LEU C   487              1.82            
REMARK 500   O    TRP G   483     CB   LEU G   487              1.82            
REMARK 500   O    TRP A   483     CB   LEU A   487              1.82            
REMARK 500   O    TRP I   483     CB   LEU I   487              1.82            
REMARK 500   O    TRP K   483     CB   LEU K   487              1.82            
REMARK 500   O    TRP M   483     CB   LEU M   487              1.82            
REMARK 500   OD2  ASP S    27     CB   ARG V    13              1.93            
REMARK 500   OD1  ASP G   209     CE   LYS O    62              1.94            
REMARK 500   CZ   TYR I   862     CB   HIS I   881              1.95            
REMARK 500   O    ASP A  1146     CG2  VAL A  1180              1.95            
REMARK 500   O    ASP C  1146     CG2  VAL C  1180              1.95            
REMARK 500   CZ   TYR E   862     CB   HIS E   881              1.96            
REMARK 500   CZ   TYR K   862     CB   HIS K   881              1.96            
REMARK 500   CZ   TYR C   862     CB   HIS C   881              1.96            
REMARK 500   CZ   TYR M   862     CB   HIS M   881              1.96            
REMARK 500   CZ   TYR G   862     CB   HIS G   881              1.96            
REMARK 500   CZ   TYR A   862     CB   HIS A   881              1.96            
REMARK 500   O    ILE G   510     OG1  THR G   514              1.96            
REMARK 500   O    ILE A   510     OG1  THR A   514              1.96            
REMARK 500   O    ILE K   510     OG1  THR K   514              1.96            
REMARK 500   O    ILE I   510     OG1  THR I   514              1.96            
REMARK 500   O    ILE E   510     OG1  THR E   514              1.96            
REMARK 500   O    ILE C   510     OG1  THR C   514              1.96            
REMARK 500   O    ILE M   510     OG1  THR M   514              1.96            
REMARK 500   OH   TYR C   845     O    VAL C   888              1.97            
REMARK 500   OH   TYR A   845     O    VAL A   888              1.97            
REMARK 500   OH   TYR E   845     O    VAL E   888              1.97            
REMARK 500   OH   TYR K   845     O    VAL K   888              1.97            
REMARK 500   OH   TYR I   845     O    VAL I   888              1.97            
REMARK 500   OH   TYR M   845     O    VAL M   888              1.97            
REMARK 500   OH   TYR G   845     O    VAL G   888              1.97            
REMARK 500   OD2  ASP Q    32     OG   SER Q    70              1.97            
REMARK 500   O    THR C   573     CB   TYR C   577              1.99            
REMARK 500   O    THR G   573     CB   TYR G   577              1.99            
REMARK 500   O    THR E   573     CB   TYR E   577              1.99            
REMARK 500   O    THR I   573     CB   TYR I   577              1.99            
REMARK 500   O    THR M   573     CB   TYR M   577              1.99            
REMARK 500   O    THR K   573     CB   TYR K   577              1.99            
REMARK 500   O    THR A   573     CB   TYR A   577              1.99            
REMARK 500   O    ASP M  1146     CG2  VAL M  1180              1.99            
REMARK 500   O    PRO M   559     N    PRO M   561              2.00            
REMARK 500   O    PRO C   559     N    PRO C   561              2.00            
REMARK 500   O    PRO G   559     N    PRO G   561              2.00            
REMARK 500   O    PRO I   559     N    PRO I   561              2.00            
REMARK 500   O    PRO A   559     N    PRO A   561              2.00            
REMARK 500   O    PRO K   559     N    PRO K   561              2.00            
REMARK 500   O    PRO E   559     N    PRO E   561              2.00            
REMARK 500   O    LEU C   639     CG2  ILE C   653              2.01            
REMARK 500   O    LEU I   639     CG2  ILE I   653              2.01            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     209 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    TRP K1179   C     VAL K1180   N      -0.146                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO A 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO A 281   C   -  N   -  CD  ANGL. DEV. = -17.4 DEGREES          
REMARK 500    PRO A 561   C   -  N   -  CD  ANGL. DEV. = -21.9 DEGREES          
REMARK 500    PRO C 147   C   -  N   -  CD  ANGL. DEV. = -13.9 DEGREES          
REMARK 500    PRO C 281   C   -  N   -  CD  ANGL. DEV. = -17.4 DEGREES          
REMARK 500    PRO C 561   C   -  N   -  CD  ANGL. DEV. = -21.9 DEGREES          
REMARK 500    PRO E 147   C   -  N   -  CD  ANGL. DEV. = -14.0 DEGREES          
REMARK 500    PRO E 281   C   -  N   -  CD  ANGL. DEV. = -17.3 DEGREES          
REMARK 500    PRO E 561   C   -  N   -  CD  ANGL. DEV. = -21.9 DEGREES          
REMARK 500    PRO G 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO G 281   C   -  N   -  CD  ANGL. DEV. = -17.3 DEGREES          
REMARK 500    PRO G 561   C   -  N   -  CD  ANGL. DEV. = -21.8 DEGREES          
REMARK 500    PRO I 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO I 281   C   -  N   -  CD  ANGL. DEV. = -17.4 DEGREES          
REMARK 500    PRO I 561   C   -  N   -  CD  ANGL. DEV. = -21.8 DEGREES          
REMARK 500    PRO K 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO K 281   C   -  N   -  CD  ANGL. DEV. = -17.4 DEGREES          
REMARK 500    PRO K 561   C   -  N   -  CD  ANGL. DEV. = -21.9 DEGREES          
REMARK 500    PRO M 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO M 281   C   -  N   -  CD  ANGL. DEV. = -17.3 DEGREES          
REMARK 500    PRO M 561   C   -  N   -  CD  ANGL. DEV. = -22.0 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    THR A 128      151.49    -40.78                                   
REMARK 500    GLU A 146      141.51     66.57                                   
REMARK 500    PRO A 147      179.45    -33.26                                   
REMARK 500    GLU A 210        7.47     82.27                                   
REMARK 500    ASP A 244     -127.44     60.93                                   
REMARK 500    VAL A 245      120.64     98.89                                   
REMARK 500    SER A 285      -69.52   -137.59                                   
REMARK 500    LEU A 286     -178.21     80.00                                   
REMARK 500    LYS A 348        4.13     87.14                                   
REMARK 500    LEU A 424      106.35   -171.69                                   
REMARK 500    TYR A 467     -127.00   -113.41                                   
REMARK 500    LYS A 495        6.04     81.34                                   
REMARK 500    LEU A 503      -72.16   -103.48                                   
REMARK 500    LEU A 533     -111.99    -97.13                                   
REMARK 500    ARG A 557      -97.18    -16.98                                   
REMARK 500    GLN A 558      -72.56   -160.34                                   
REMARK 500    PRO A 559       60.36    -50.33                                   
REMARK 500    PHE A 560       63.67    -42.92                                   
REMARK 500    PRO A 561      132.25    -20.20                                   
REMARK 500    ASN A 562       87.51    -46.47                                   
REMARK 500    LEU A 568       61.95    -63.62                                   
REMARK 500    GLU A 572      -94.76     72.91                                   
REMARK 500    THR A 573      -65.73   -175.14                                   
REMARK 500    SER A 574      169.11     46.10                                   
REMARK 500    MET A 592       -8.19     89.53                                   
REMARK 500    THR A 604      110.33     76.21                                   
REMARK 500    CYS A 633     -154.15    -98.95                                   
REMARK 500    LYS A 637       -1.67     97.20                                   
REMARK 500    GLU A 645      -93.53    -42.10                                   
REMARK 500    ASP A 658     -176.92     80.46                                   
REMARK 500    LYS A 679       26.40     91.98                                   
REMARK 500    MET A 687      -68.11   -108.97                                   
REMARK 500    VAL A 692      -71.95   -122.25                                   
REMARK 500    GLU A 697      -27.28   -165.08                                   
REMARK 500    HIS A 712      -76.75    -80.08                                   
REMARK 500    CYS A 723      -28.27     81.17                                   
REMARK 500    ASN A 737      113.93   -168.24                                   
REMARK 500    ARG A 778      -55.48   -124.63                                   
REMARK 500    SER A 780       92.68   -164.75                                   
REMARK 500    LEU A 788      102.67   -163.82                                   
REMARK 500    GLU A 795     -129.02    -72.45                                   
REMARK 500    LYS A 802      -84.20   -109.17                                   
REMARK 500    CYS A 804       69.30   -105.10                                   
REMARK 500    LYS A 818     -102.91     52.89                                   
REMARK 500    LEU A 832      -78.24   -129.31                                   
REMARK 500    GLU A 834       91.57   -168.00                                   
REMARK 500    HIS A 839     -138.46     49.68                                   
REMARK 500    SER A 841     -122.68   -174.38                                   
REMARK 500    ASP A 847      107.87   -160.89                                   
REMARK 500    ASN A 852       12.45     53.06                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     720 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    ARG T  52         0.18    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG A1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER A 161   OG                                                     
REMARK 620 2 DTP A1301   O3G 136.1                                              
REMARK 620 3 DTP A1301   O2B  74.7  69.6                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM B 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS B  18   NE2                                                    
REMARK 620 2 HEM B 201   NA  107.7                                              
REMARK 620 3 HEM B 201   NB  112.2  88.0                                        
REMARK 620 4 HEM B 201   NC   73.0 173.7  86.0                                  
REMARK 620 5 HEM B 201   ND   68.1  93.7 178.1  92.3                            
REMARK 620 6 MET B  80   SD  149.0  88.5  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG C1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER C 161   OG                                                     
REMARK 620 2 DTP C1301   O3G 136.2                                              
REMARK 620 3 DTP C1301   O2B  74.8  69.7                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM D 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS D  18   NE2                                                    
REMARK 620 2 HEM D 201   NA  107.6                                              
REMARK 620 3 HEM D 201   NB  112.2  88.0                                        
REMARK 620 4 HEM D 201   NC   73.1 173.7  86.0                                  
REMARK 620 5 HEM D 201   ND   68.1  93.7 178.1  92.3                            
REMARK 620 6 MET D  80   SD  149.1  88.5  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG E1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER E 161   OG                                                     
REMARK 620 2 DTP E1301   O3G 136.2                                              
REMARK 620 3 DTP E1301   O2B  74.8  69.7                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM F 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS F  18   NE2                                                    
REMARK 620 2 HEM F 201   NA  107.7                                              
REMARK 620 3 HEM F 201   NB  112.2  88.0                                        
REMARK 620 4 HEM F 201   NC   73.0 173.6  85.9                                  
REMARK 620 5 HEM F 201   ND   68.1  93.8 178.0  92.3                            
REMARK 620 6 MET F  80   SD  149.0  88.5  94.2  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG G1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER G 161   OG                                                     
REMARK 620 2 DTP G1301   O3G 136.2                                              
REMARK 620 3 DTP G1301   O2B  74.8  69.7                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM H 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS H  18   NE2                                                    
REMARK 620 2 HEM H 201   NA  107.7                                              
REMARK 620 3 HEM H 201   NB  112.3  87.9                                        
REMARK 620 4 HEM H 201   NC   73.1 173.6  86.0                                  
REMARK 620 5 HEM H 201   ND   68.1  93.8 178.1  92.3                            
REMARK 620 6 MET H  80   SD  149.0  88.5  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG I1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER I 161   OG                                                     
REMARK 620 2 DTP I1301   O3G 136.2                                              
REMARK 620 3 DTP I1301   O2B  74.8  69.7                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM J 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS J  18   NE2                                                    
REMARK 620 2 HEM J 201   NA  107.6                                              
REMARK 620 3 HEM J 201   NB  112.3  87.9                                        
REMARK 620 4 HEM J 201   NC   73.1 173.6  86.0                                  
REMARK 620 5 HEM J 201   ND   68.1  93.7 178.1  92.4                            
REMARK 620 6 MET J  80   SD  149.1  88.5  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG K1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER K 161   OG                                                     
REMARK 620 2 DTP K1301   O3G 136.2                                              
REMARK 620 3 DTP K1301   O2B  74.7  69.7                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM L 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS L  18   NE2                                                    
REMARK 620 2 HEM L 201   NA  107.6                                              
REMARK 620 3 HEM L 201   NB  112.2  87.9                                        
REMARK 620 4 HEM L 201   NC   73.1 173.6  86.0                                  
REMARK 620 5 HEM L 201   ND   68.2  93.8 178.1  92.4                            
REMARK 620 6 MET L  80   SD  149.2  88.4  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG M1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER M 161   OG                                                     
REMARK 620 2 DTP M1301   O3G 136.2                                              
REMARK 620 3 DTP M1301   O2B  74.8  69.7                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM N 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS N  18   NE2                                                    
REMARK 620 2 HEM N 201   NA  107.6                                              
REMARK 620 3 HEM N 201   NB  112.2  87.9                                        
REMARK 620 4 HEM N 201   NC   73.2 173.7  86.0                                  
REMARK 620 5 HEM N 201   ND   68.1  93.8 178.1  92.3                            
REMARK 620 6 MET N  80   SD  149.1  88.4  94.2  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP A 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG A 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM B 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP C 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG C 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM D 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP E 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG E 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM F 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP G 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG G 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM H 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP I 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG I 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM J 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP K 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG K 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM L 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue DTP M 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG M 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue HEM N 201                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-6690   RELATED DB: EMDB                              
REMARK 900 APAF-1-CASPASE-9 HOLOENZYME                                          
DBREF  5WVE A    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  5WVE B    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  5WVE C    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  5WVE D    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  5WVE E    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  5WVE F    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  5WVE G    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  5WVE H    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  5WVE I    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  5WVE J    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  5WVE K    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  5WVE L    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  5WVE M    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  5WVE N    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  5WVE O    1   102  UNP    O14727   APAF_HUMAN       1    102             
DBREF  5WVE P    1   102  UNP    O14727   APAF_HUMAN       1    102             
DBREF  5WVE Q    1   102  UNP    O14727   APAF_HUMAN       1    102             
DBREF  5WVE R    1   102  UNP    O14727   APAF_HUMAN       1    102             
DBREF  5WVE S    1   100  UNP    A8K7U6   A8K7U6_HUMAN     1    100             
DBREF  5WVE T    1   100  UNP    A8K7U6   A8K7U6_HUMAN     1    100             
DBREF  5WVE U    1   100  UNP    A8K7U6   A8K7U6_HUMAN     1    100             
DBREF  5WVE V    1   100  UNP    A8K7U6   A8K7U6_HUMAN     1    100             
DBREF  5WVE W    1   102  UNP    O14727   APAF_HUMAN       1    102             
DBREF  5WVE X    1   102  UNP    O14727   APAF_HUMAN       1    102             
DBREF  5WVE Y    1   100  UNP    A8K7U6   A8K7U6_HUMAN     1    100             
SEQRES   1 A 1248  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 A 1248  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 A 1248  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 A 1248  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 A 1248  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 A 1248  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 A 1248  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 A 1248  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 A 1248  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 A 1248  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 A 1248  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 A 1248  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 A 1248  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 A 1248  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 A 1248  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 A 1248  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 A 1248  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 A 1248  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 A 1248  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 A 1248  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 A 1248  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 A 1248  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 A 1248  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 A 1248  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 A 1248  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 A 1248  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 A 1248  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 A 1248  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 A 1248  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 A 1248  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 A 1248  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 A 1248  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 A 1248  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 A 1248  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 A 1248  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 A 1248  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 A 1248  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 A 1248  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 A 1248  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 A 1248  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 A 1248  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 A 1248  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 A 1248  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 A 1248  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 A 1248  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 A 1248  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 A 1248  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 A 1248  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 A 1248  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 A 1248  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 A 1248  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 A 1248  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 A 1248  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 A 1248  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 A 1248  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 A 1248  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 A 1248  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 A 1248  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 A 1248  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 A 1248  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 A 1248  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 A 1248  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 A 1248  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 A 1248  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 A 1248  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 A 1248  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 A 1248  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 A 1248  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 A 1248  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 A 1248  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 A 1248  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 A 1248  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 A 1248  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 A 1248  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 A 1248  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 A 1248  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 A 1248  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 A 1248  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 A 1248  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 A 1248  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 A 1248  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 A 1248  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 A 1248  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 A 1248  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 A 1248  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 A 1248  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 A 1248  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 A 1248  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 A 1248  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 A 1248  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 A 1248  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 A 1248  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 A 1248  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 A 1248  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 A 1248  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 A 1248  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES   1 B  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 B  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 B  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 B  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 B  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 B  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 B  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 B  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 B  105  GLU                                                          
SEQRES   1 C 1248  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 C 1248  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 C 1248  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 C 1248  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 C 1248  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 C 1248  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 C 1248  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 C 1248  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 C 1248  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 C 1248  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 C 1248  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 C 1248  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 C 1248  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 C 1248  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 C 1248  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 C 1248  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 C 1248  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 C 1248  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 C 1248  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 C 1248  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 C 1248  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 C 1248  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 C 1248  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 C 1248  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 C 1248  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 C 1248  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 C 1248  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 C 1248  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 C 1248  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 C 1248  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 C 1248  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 C 1248  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 C 1248  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 C 1248  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 C 1248  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 C 1248  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 C 1248  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 C 1248  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 C 1248  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 C 1248  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 C 1248  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 C 1248  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 C 1248  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 C 1248  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 C 1248  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 C 1248  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 C 1248  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 C 1248  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 C 1248  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 C 1248  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 C 1248  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 C 1248  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 C 1248  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 C 1248  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 C 1248  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 C 1248  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 C 1248  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 C 1248  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 C 1248  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 C 1248  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 C 1248  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 C 1248  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 C 1248  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 C 1248  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 C 1248  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 C 1248  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 C 1248  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 C 1248  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 C 1248  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 C 1248  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 C 1248  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 C 1248  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 C 1248  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 C 1248  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 C 1248  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 C 1248  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 C 1248  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 C 1248  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 C 1248  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 C 1248  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 C 1248  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 C 1248  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 C 1248  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 C 1248  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 C 1248  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 C 1248  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 C 1248  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 C 1248  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 C 1248  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 C 1248  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 C 1248  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 C 1248  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 C 1248  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 C 1248  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 C 1248  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 C 1248  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES   1 D  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 D  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 D  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 D  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 D  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 D  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 D  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 D  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 D  105  GLU                                                          
SEQRES   1 E 1248  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 E 1248  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 E 1248  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 E 1248  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 E 1248  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 E 1248  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 E 1248  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 E 1248  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 E 1248  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 E 1248  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 E 1248  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 E 1248  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 E 1248  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 E 1248  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 E 1248  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 E 1248  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 E 1248  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 E 1248  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 E 1248  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 E 1248  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 E 1248  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 E 1248  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 E 1248  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 E 1248  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 E 1248  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 E 1248  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 E 1248  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 E 1248  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 E 1248  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 E 1248  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 E 1248  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 E 1248  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 E 1248  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 E 1248  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 E 1248  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 E 1248  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 E 1248  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 E 1248  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 E 1248  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 E 1248  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 E 1248  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 E 1248  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 E 1248  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 E 1248  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 E 1248  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 E 1248  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 E 1248  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 E 1248  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 E 1248  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 E 1248  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 E 1248  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 E 1248  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 E 1248  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 E 1248  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 E 1248  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 E 1248  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 E 1248  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 E 1248  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 E 1248  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 E 1248  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 E 1248  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 E 1248  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 E 1248  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 E 1248  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 E 1248  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 E 1248  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 E 1248  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 E 1248  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 E 1248  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 E 1248  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 E 1248  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 E 1248  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 E 1248  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 E 1248  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 E 1248  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 E 1248  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 E 1248  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 E 1248  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 E 1248  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 E 1248  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 E 1248  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 E 1248  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 E 1248  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 E 1248  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 E 1248  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 E 1248  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 E 1248  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 E 1248  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 E 1248  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 E 1248  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 E 1248  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 E 1248  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 E 1248  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 E 1248  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 E 1248  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 E 1248  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES   1 F  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 F  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 F  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 F  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 F  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 F  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 F  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 F  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 F  105  GLU                                                          
SEQRES   1 G 1248  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 G 1248  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 G 1248  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 G 1248  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 G 1248  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 G 1248  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 G 1248  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 G 1248  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 G 1248  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 G 1248  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 G 1248  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 G 1248  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 G 1248  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 G 1248  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 G 1248  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 G 1248  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 G 1248  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 G 1248  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 G 1248  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 G 1248  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 G 1248  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 G 1248  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 G 1248  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 G 1248  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 G 1248  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 G 1248  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 G 1248  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 G 1248  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 G 1248  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 G 1248  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 G 1248  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 G 1248  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 G 1248  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 G 1248  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 G 1248  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 G 1248  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 G 1248  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 G 1248  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 G 1248  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 G 1248  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 G 1248  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 G 1248  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 G 1248  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 G 1248  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 G 1248  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 G 1248  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 G 1248  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 G 1248  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 G 1248  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 G 1248  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 G 1248  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 G 1248  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 G 1248  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 G 1248  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 G 1248  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 G 1248  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 G 1248  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 G 1248  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 G 1248  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 G 1248  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 G 1248  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 G 1248  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 G 1248  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 G 1248  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 G 1248  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 G 1248  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 G 1248  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 G 1248  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 G 1248  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 G 1248  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 G 1248  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 G 1248  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 G 1248  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 G 1248  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 G 1248  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 G 1248  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 G 1248  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 G 1248  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 G 1248  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 G 1248  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 G 1248  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 G 1248  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 G 1248  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 G 1248  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 G 1248  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 G 1248  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 G 1248  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 G 1248  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 G 1248  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 G 1248  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 G 1248  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 G 1248  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 G 1248  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 G 1248  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 G 1248  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 G 1248  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES   1 H  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 H  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 H  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 H  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 H  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 H  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 H  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 H  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 H  105  GLU                                                          
SEQRES   1 I 1248  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 I 1248  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 I 1248  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 I 1248  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 I 1248  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 I 1248  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 I 1248  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 I 1248  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 I 1248  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 I 1248  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 I 1248  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 I 1248  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 I 1248  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 I 1248  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 I 1248  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 I 1248  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 I 1248  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 I 1248  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 I 1248  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 I 1248  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 I 1248  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 I 1248  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 I 1248  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 I 1248  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 I 1248  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 I 1248  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 I 1248  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 I 1248  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 I 1248  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 I 1248  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 I 1248  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 I 1248  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 I 1248  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 I 1248  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 I 1248  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 I 1248  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 I 1248  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 I 1248  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 I 1248  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 I 1248  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 I 1248  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 I 1248  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 I 1248  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 I 1248  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 I 1248  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 I 1248  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 I 1248  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 I 1248  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 I 1248  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 I 1248  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 I 1248  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 I 1248  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 I 1248  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 I 1248  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 I 1248  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 I 1248  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 I 1248  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 I 1248  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 I 1248  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 I 1248  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 I 1248  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 I 1248  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 I 1248  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 I 1248  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 I 1248  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 I 1248  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 I 1248  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 I 1248  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 I 1248  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 I 1248  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 I 1248  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 I 1248  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 I 1248  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 I 1248  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 I 1248  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 I 1248  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 I 1248  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 I 1248  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 I 1248  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 I 1248  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 I 1248  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 I 1248  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 I 1248  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 I 1248  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 I 1248  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 I 1248  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 I 1248  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 I 1248  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 I 1248  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 I 1248  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 I 1248  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 I 1248  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 I 1248  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 I 1248  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 I 1248  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 I 1248  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES   1 J  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 J  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 J  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 J  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 J  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 J  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 J  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 J  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 J  105  GLU                                                          
SEQRES   1 K 1248  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 K 1248  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 K 1248  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 K 1248  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 K 1248  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 K 1248  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 K 1248  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 K 1248  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 K 1248  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 K 1248  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 K 1248  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 K 1248  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 K 1248  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 K 1248  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 K 1248  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 K 1248  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 K 1248  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 K 1248  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 K 1248  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 K 1248  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 K 1248  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 K 1248  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 K 1248  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 K 1248  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 K 1248  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 K 1248  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 K 1248  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 K 1248  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 K 1248  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 K 1248  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 K 1248  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 K 1248  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 K 1248  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 K 1248  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 K 1248  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 K 1248  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 K 1248  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 K 1248  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 K 1248  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 K 1248  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 K 1248  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 K 1248  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 K 1248  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 K 1248  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 K 1248  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 K 1248  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 K 1248  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 K 1248  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 K 1248  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 K 1248  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 K 1248  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 K 1248  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 K 1248  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 K 1248  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 K 1248  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 K 1248  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 K 1248  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 K 1248  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 K 1248  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 K 1248  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 K 1248  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 K 1248  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 K 1248  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 K 1248  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 K 1248  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 K 1248  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 K 1248  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 K 1248  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 K 1248  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 K 1248  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 K 1248  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 K 1248  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 K 1248  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 K 1248  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 K 1248  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 K 1248  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 K 1248  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 K 1248  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 K 1248  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 K 1248  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 K 1248  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 K 1248  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 K 1248  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 K 1248  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 K 1248  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 K 1248  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 K 1248  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 K 1248  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 K 1248  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 K 1248  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 K 1248  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 K 1248  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 K 1248  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 K 1248  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 K 1248  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 K 1248  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES   1 L  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 L  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 L  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 L  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 L  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 L  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 L  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 L  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 L  105  GLU                                                          
SEQRES   1 M 1248  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 M 1248  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 M 1248  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 M 1248  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 M 1248  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 M 1248  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 M 1248  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 M 1248  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 M 1248  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 M 1248  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 M 1248  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 M 1248  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 M 1248  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 M 1248  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 M 1248  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 M 1248  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 M 1248  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 M 1248  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 M 1248  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 M 1248  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 M 1248  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 M 1248  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 M 1248  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 M 1248  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 M 1248  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 M 1248  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 M 1248  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 M 1248  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 M 1248  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 M 1248  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 M 1248  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 M 1248  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 M 1248  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 M 1248  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 M 1248  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 M 1248  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 M 1248  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 M 1248  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 M 1248  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 M 1248  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 M 1248  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 M 1248  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 M 1248  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 M 1248  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 M 1248  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 M 1248  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 M 1248  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 M 1248  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 M 1248  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 M 1248  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 M 1248  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 M 1248  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 M 1248  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 M 1248  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 M 1248  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 M 1248  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 M 1248  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 M 1248  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 M 1248  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 M 1248  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 M 1248  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 M 1248  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 M 1248  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 M 1248  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 M 1248  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 M 1248  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 M 1248  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 M 1248  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 M 1248  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 M 1248  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 M 1248  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 M 1248  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 M 1248  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 M 1248  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 M 1248  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 M 1248  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 M 1248  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 M 1248  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 M 1248  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 M 1248  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 M 1248  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 M 1248  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 M 1248  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 M 1248  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 M 1248  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 M 1248  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 M 1248  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 M 1248  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 M 1248  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 M 1248  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 M 1248  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 M 1248  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 M 1248  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 M 1248  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 M 1248  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 M 1248  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES   1 N  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 N  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 N  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 N  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 N  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 N  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 N  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 N  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 N  105  GLU                                                          
SEQRES   1 O  102  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 O  102  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 O  102  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 O  102  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 O  102  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 O  102  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 O  102  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 O  102  PRO VAL VAL SER SER SER SER GLY LYS ASP SER                  
SEQRES   1 P  102  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 P  102  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 P  102  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 P  102  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 P  102  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 P  102  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 P  102  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 P  102  PRO VAL VAL SER SER SER SER GLY LYS ASP SER                  
SEQRES   1 Q  102  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 Q  102  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 Q  102  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 Q  102  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 Q  102  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 Q  102  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 Q  102  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 Q  102  PRO VAL VAL SER SER SER SER GLY LYS ASP SER                  
SEQRES   1 R  102  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 R  102  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 R  102  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 R  102  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 R  102  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 R  102  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 R  102  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 R  102  PRO VAL VAL SER SER SER SER GLY LYS ASP SER                  
SEQRES   1 S  100  MET ASP GLU ALA ASP ARG ARG LEU LEU ARG ARG CYS ARG          
SEQRES   2 S  100  LEU ARG LEU VAL GLU GLU LEU GLN VAL ASP GLN LEU TRP          
SEQRES   3 S  100  ASP VAL LEU LEU SER ARG GLU LEU PHE ARG PRO HIS MET          
SEQRES   4 S  100  ILE GLU ASP ILE GLN ARG ALA GLY SER GLY SER ARG ARG          
SEQRES   5 S  100  ASP GLN ALA ARG GLN LEU ILE ILE ASP LEU GLU THR ARG          
SEQRES   6 S  100  GLY SER GLN ALA LEU PRO LEU PHE ILE SER CYS LEU GLU          
SEQRES   7 S  100  ASP THR GLY GLN ASP MET LEU ALA SER PHE LEU ARG THR          
SEQRES   8 S  100  ASN ARG GLN ALA ALA LYS LEU SER LYS                          
SEQRES   1 T  100  MET ASP GLU ALA ASP ARG ARG LEU LEU ARG ARG CYS ARG          
SEQRES   2 T  100  LEU ARG LEU VAL GLU GLU LEU GLN VAL ASP GLN LEU TRP          
SEQRES   3 T  100  ASP VAL LEU LEU SER ARG GLU LEU PHE ARG PRO HIS MET          
SEQRES   4 T  100  ILE GLU ASP ILE GLN ARG ALA GLY SER GLY SER ARG ARG          
SEQRES   5 T  100  ASP GLN ALA ARG GLN LEU ILE ILE ASP LEU GLU THR ARG          
SEQRES   6 T  100  GLY SER GLN ALA LEU PRO LEU PHE ILE SER CYS LEU GLU          
SEQRES   7 T  100  ASP THR GLY GLN ASP MET LEU ALA SER PHE LEU ARG THR          
SEQRES   8 T  100  ASN ARG GLN ALA ALA LYS LEU SER LYS                          
SEQRES   1 U  100  MET ASP GLU ALA ASP ARG ARG LEU LEU ARG ARG CYS ARG          
SEQRES   2 U  100  LEU ARG LEU VAL GLU GLU LEU GLN VAL ASP GLN LEU TRP          
SEQRES   3 U  100  ASP VAL LEU LEU SER ARG GLU LEU PHE ARG PRO HIS MET          
SEQRES   4 U  100  ILE GLU ASP ILE GLN ARG ALA GLY SER GLY SER ARG ARG          
SEQRES   5 U  100  ASP GLN ALA ARG GLN LEU ILE ILE ASP LEU GLU THR ARG          
SEQRES   6 U  100  GLY SER GLN ALA LEU PRO LEU PHE ILE SER CYS LEU GLU          
SEQRES   7 U  100  ASP THR GLY GLN ASP MET LEU ALA SER PHE LEU ARG THR          
SEQRES   8 U  100  ASN ARG GLN ALA ALA LYS LEU SER LYS                          
SEQRES   1 V  100  MET ASP GLU ALA ASP ARG ARG LEU LEU ARG ARG CYS ARG          
SEQRES   2 V  100  LEU ARG LEU VAL GLU GLU LEU GLN VAL ASP GLN LEU TRP          
SEQRES   3 V  100  ASP VAL LEU LEU SER ARG GLU LEU PHE ARG PRO HIS MET          
SEQRES   4 V  100  ILE GLU ASP ILE GLN ARG ALA GLY SER GLY SER ARG ARG          
SEQRES   5 V  100  ASP GLN ALA ARG GLN LEU ILE ILE ASP LEU GLU THR ARG          
SEQRES   6 V  100  GLY SER GLN ALA LEU PRO LEU PHE ILE SER CYS LEU GLU          
SEQRES   7 V  100  ASP THR GLY GLN ASP MET LEU ALA SER PHE LEU ARG THR          
SEQRES   8 V  100  ASN ARG GLN ALA ALA LYS LEU SER LYS                          
SEQRES   1 W  102  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 W  102  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 W  102  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 W  102  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 W  102  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 W  102  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 W  102  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 W  102  PRO VAL VAL SER SER SER SER GLY LYS ASP SER                  
SEQRES   1 X  102  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 X  102  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 X  102  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 X  102  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 X  102  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 X  102  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 X  102  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 X  102  PRO VAL VAL SER SER SER SER GLY LYS ASP SER                  
SEQRES   1 Y  100  MET ASP GLU ALA ASP ARG ARG LEU LEU ARG ARG CYS ARG          
SEQRES   2 Y  100  LEU ARG LEU VAL GLU GLU LEU GLN VAL ASP GLN LEU TRP          
SEQRES   3 Y  100  ASP VAL LEU LEU SER ARG GLU LEU PHE ARG PRO HIS MET          
SEQRES   4 Y  100  ILE GLU ASP ILE GLN ARG ALA GLY SER GLY SER ARG ARG          
SEQRES   5 Y  100  ASP GLN ALA ARG GLN LEU ILE ILE ASP LEU GLU THR ARG          
SEQRES   6 Y  100  GLY SER GLN ALA LEU PRO LEU PHE ILE SER CYS LEU GLU          
SEQRES   7 Y  100  ASP THR GLY GLN ASP MET LEU ALA SER PHE LEU ARG THR          
SEQRES   8 Y  100  ASN ARG GLN ALA ALA LYS LEU SER LYS                          
HET    DTP  A1301      30                                                       
HET     MG  A1302       1                                                       
HET    HEM  B 201      43                                                       
HET    DTP  C1301      30                                                       
HET     MG  C1302       1                                                       
HET    HEM  D 201      43                                                       
HET    DTP  E1301      30                                                       
HET     MG  E1302       1                                                       
HET    HEM  F 201      43                                                       
HET    DTP  G1301      30                                                       
HET     MG  G1302       1                                                       
HET    HEM  H 201      43                                                       
HET    DTP  I1301      30                                                       
HET     MG  I1302       1                                                       
HET    HEM  J 201      43                                                       
HET    DTP  K1301      30                                                       
HET     MG  K1302       1                                                       
HET    HEM  L 201      43                                                       
HET    DTP  M1301      30                                                       
HET     MG  M1302       1                                                       
HET    HEM  N 201      43                                                       
HETNAM     DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE                                
HETNAM      MG MAGNESIUM ION                                                    
HETNAM     HEM PROTOPORPHYRIN IX CONTAINING FE                                  
HETSYN     HEM HEME                                                             
FORMUL  26  DTP    7(C10 H16 N5 O12 P3)                                         
FORMUL  27   MG    7(MG 2+)                                                     
FORMUL  28  HEM    7(C34 H32 FE N4 O4)                                          
HELIX    1 AA1 THR A  107  GLY A  118  1                                  12    
HELIX    2 AA2 ARG A  129  LEU A  143  1                                  15    
HELIX    3 AA3 GLY A  159  ASP A  170  1                                  12    
HELIX    4 AA4 ASP A  170  PHE A  178  1                                   9    
HELIX    5 AA5 ASP A  191  ASP A  207  1                                  17    
HELIX    6 AA6 ASN A  219  ARG A  233  1                                  15    
HELIX    7 AA7 ASP A  247  ASP A  255  1                                   9    
HELIX    8 AA8 GLY A  287  ASN A  300  1                                  14    
HELIX    9 AA9 PRO A  307  LYS A  318  1                                  12    
HELIX   10 AB1 SER A  320  PHE A  334  1                                  15    
HELIX   11 AB2 ARG A  337  LYS A  348  1                                  12    
HELIX   12 AB3 ALA A  363  MET A  374  1                                  12    
HELIX   13 AB4 ARG A  376  LEU A  386  1                                  11    
HELIX   14 AB5 THR A  397  ASP A  405  1                                   9    
HELIX   15 AB6 GLU A  407  LYS A  421  1                                  15    
HELIX   16 AB7 HIS A  438  TYR A  467  1                                  30    
HELIX   17 AB8 ASP A  479  LYS A  495  1                                  17    
HELIX   18 AB9 MET A  496  MET A  504  1                                   9    
HELIX   19 AC1 SER A  506  GLY A  518  1                                  13    
HELIX   20 AC2 ALA A  520  LEU A  533  1                                  14    
HELIX   21 AC3 ASP A  534  LEU A  550  1                                  17    
HELIX   22 AC4 LEU A  550  LEU A  555  1                                   6    
HELIX   23 AC5 ASN A  562  GLY A  567  1                                   6    
HELIX   24 AC6 THR A  573  GLY A  591  1                                  19    
HELIX   25 AC7 ASN A  599  ILE A  603  5                                   5    
HELIX   26 AC8 PRO A  850  ASN A  852  5                                   3    
HELIX   27 AC9 THR A  911  LYS A  916  1                                   6    
HELIX   28 AD1 ASP B    2  CYS B   14  1                                  13    
HELIX   29 AD2 THR B   49  LYS B   55  1                                   7    
HELIX   30 AD3 LYS B   60  ASN B   70  1                                  11    
HELIX   31 AD4 ASN B   70  ILE B   75  1                                   6    
HELIX   32 AD5 LYS B   87  THR B  102  1                                  16    
HELIX   33 AD6 THR C  107  GLY C  118  1                                  12    
HELIX   34 AD7 ARG C  129  LEU C  143  1                                  15    
HELIX   35 AD8 GLY C  159  ASP C  170  1                                  12    
HELIX   36 AD9 ASP C  170  PHE C  178  1                                   9    
HELIX   37 AE1 ASP C  191  ASP C  207  1                                  17    
HELIX   38 AE2 ASN C  219  ARG C  233  1                                  15    
HELIX   39 AE3 ASP C  247  ASP C  255  1                                   9    
HELIX   40 AE4 GLY C  287  ASN C  300  1                                  14    
HELIX   41 AE5 PRO C  307  LYS C  318  1                                  12    
HELIX   42 AE6 SER C  320  PHE C  334  1                                  15    
HELIX   43 AE7 ARG C  337  LYS C  348  1                                  12    
HELIX   44 AE8 ALA C  363  MET C  374  1                                  12    
HELIX   45 AE9 ARG C  376  LEU C  386  1                                  11    
HELIX   46 AF1 THR C  397  ASP C  405  1                                   9    
HELIX   47 AF2 GLU C  407  LYS C  421  1                                  15    
HELIX   48 AF3 HIS C  438  TYR C  467  1                                  30    
HELIX   49 AF4 ASP C  479  LYS C  495  1                                  17    
HELIX   50 AF5 MET C  496  MET C  504  1                                   9    
HELIX   51 AF6 SER C  506  GLY C  518  1                                  13    
HELIX   52 AF7 ALA C  520  LEU C  533  1                                  14    
HELIX   53 AF8 ASP C  534  LEU C  550  1                                  17    
HELIX   54 AF9 LEU C  550  LEU C  555  1                                   6    
HELIX   55 AG1 ASN C  562  GLY C  567  1                                   6    
HELIX   56 AG2 THR C  573  GLY C  591  1                                  19    
HELIX   57 AG3 ASN C  599  ILE C  603  5                                   5    
HELIX   58 AG4 PRO C  850  ASN C  852  5                                   3    
HELIX   59 AG5 THR C  911  LYS C  916  1                                   6    
HELIX   60 AG6 ASP D    2  CYS D   14  1                                  13    
HELIX   61 AG7 THR D   49  LYS D   55  1                                   7    
HELIX   62 AG8 LYS D   60  ASN D   70  1                                  11    
HELIX   63 AG9 ASN D   70  ILE D   75  1                                   6    
HELIX   64 AH1 LYS D   87  THR D  102  1                                  16    
HELIX   65 AH2 THR E  107  GLY E  118  1                                  12    
HELIX   66 AH3 ARG E  129  LEU E  143  1                                  15    
HELIX   67 AH4 GLY E  159  ASP E  170  1                                  12    
HELIX   68 AH5 ASP E  170  PHE E  178  1                                   9    
HELIX   69 AH6 ASP E  191  ASP E  207  1                                  17    
HELIX   70 AH7 ASN E  219  ARG E  233  1                                  15    
HELIX   71 AH8 ASP E  247  ASP E  255  1                                   9    
HELIX   72 AH9 GLY E  287  ASN E  300  1                                  14    
HELIX   73 AI1 GLN E  309  LYS E  318  1                                  10    
HELIX   74 AI2 SER E  320  PHE E  334  1                                  15    
HELIX   75 AI3 ARG E  337  LYS E  348  1                                  12    
HELIX   76 AI4 ALA E  363  MET E  374  1                                  12    
HELIX   77 AI5 ARG E  376  LEU E  386  1                                  11    
HELIX   78 AI6 THR E  397  ASP E  405  1                                   9    
HELIX   79 AI7 GLU E  407  LYS E  421  1                                  15    
HELIX   80 AI8 HIS E  438  TYR E  467  1                                  30    
HELIX   81 AI9 ASP E  479  LYS E  495  1                                  17    
HELIX   82 AJ1 MET E  496  MET E  504  1                                   9    
HELIX   83 AJ2 SER E  506  GLY E  518  1                                  13    
HELIX   84 AJ3 ALA E  520  LEU E  533  1                                  14    
HELIX   85 AJ4 ASP E  534  LEU E  550  1                                  17    
HELIX   86 AJ5 LEU E  550  LEU E  555  1                                   6    
HELIX   87 AJ6 ASN E  562  GLY E  567  1                                   6    
HELIX   88 AJ7 THR E  573  GLY E  591  1                                  19    
HELIX   89 AJ8 ASN E  599  ILE E  603  5                                   5    
HELIX   90 AJ9 PRO E  850  ASN E  852  5                                   3    
HELIX   91 AK1 THR E  911  LYS E  916  1                                   6    
HELIX   92 AK2 ASP F    2  CYS F   14  1                                  13    
HELIX   93 AK3 THR F   49  LYS F   55  1                                   7    
HELIX   94 AK4 LYS F   60  ASN F   70  1                                  11    
HELIX   95 AK5 ASN F   70  ILE F   75  1                                   6    
HELIX   96 AK6 LYS F   87  THR F  102  1                                  16    
HELIX   97 AK7 THR G  107  GLY G  118  1                                  12    
HELIX   98 AK8 ARG G  129  LEU G  143  1                                  15    
HELIX   99 AK9 GLY G  159  ASP G  170  1                                  12    
HELIX  100 AL1 ASP G  170  PHE G  178  1                                   9    
HELIX  101 AL2 ASP G  191  ASP G  207  1                                  17    
HELIX  102 AL3 ASN G  219  ARG G  233  1                                  15    
HELIX  103 AL4 ASP G  247  ASP G  255  1                                   9    
HELIX  104 AL5 GLY G  287  ASN G  300  1                                  14    
HELIX  105 AL6 PRO G  307  LYS G  318  1                                  12    
HELIX  106 AL7 SER G  320  PHE G  334  1                                  15    
HELIX  107 AL8 ARG G  337  LYS G  348  1                                  12    
HELIX  108 AL9 ALA G  363  MET G  374  1                                  12    
HELIX  109 AM1 ARG G  376  LEU G  386  1                                  11    
HELIX  110 AM2 THR G  397  ASP G  405  1                                   9    
HELIX  111 AM3 GLU G  407  LYS G  421  1                                  15    
HELIX  112 AM4 HIS G  438  TYR G  467  1                                  30    
HELIX  113 AM5 ASP G  479  LYS G  495  1                                  17    
HELIX  114 AM6 MET G  496  MET G  504  1                                   9    
HELIX  115 AM7 SER G  506  GLY G  518  1                                  13    
HELIX  116 AM8 ALA G  520  LEU G  533  1                                  14    
HELIX  117 AM9 ASP G  534  LEU G  550  1                                  17    
HELIX  118 AN1 LEU G  550  LEU G  555  1                                   6    
HELIX  119 AN2 ASN G  562  GLY G  567  1                                   6    
HELIX  120 AN3 THR G  573  GLY G  591  1                                  19    
HELIX  121 AN4 ASN G  599  ILE G  603  5                                   5    
HELIX  122 AN5 PRO G  850  ASN G  852  5                                   3    
HELIX  123 AN6 THR G  911  LYS G  916  1                                   6    
HELIX  124 AN7 ASP H    2  CYS H   14  1                                  13    
HELIX  125 AN8 THR H   49  LYS H   55  1                                   7    
HELIX  126 AN9 LYS H   60  ASN H   70  1                                  11    
HELIX  127 AO1 ASN H   70  ILE H   75  1                                   6    
HELIX  128 AO2 LYS H   87  THR H  102  1                                  16    
HELIX  129 AO3 THR I  107  GLY I  118  1                                  12    
HELIX  130 AO4 ARG I  129  LEU I  143  1                                  15    
HELIX  131 AO5 GLY I  159  ASP I  170  1                                  12    
HELIX  132 AO6 ASP I  170  PHE I  178  1                                   9    
HELIX  133 AO7 ASP I  191  ASP I  207  1                                  17    
HELIX  134 AO8 ASN I  219  ARG I  233  1                                  15    
HELIX  135 AO9 ASP I  247  ASP I  255  1                                   9    
HELIX  136 AP1 GLY I  287  ASN I  300  1                                  14    
HELIX  137 AP2 PRO I  307  LYS I  318  1                                  12    
HELIX  138 AP3 SER I  320  PHE I  334  1                                  15    
HELIX  139 AP4 ARG I  337  LYS I  348  1                                  12    
HELIX  140 AP5 ALA I  363  MET I  374  1                                  12    
HELIX  141 AP6 ARG I  376  LEU I  386  1                                  11    
HELIX  142 AP7 THR I  397  ASP I  405  1                                   9    
HELIX  143 AP8 GLU I  407  LYS I  421  1                                  15    
HELIX  144 AP9 HIS I  438  TYR I  467  1                                  30    
HELIX  145 AQ1 ASP I  479  LYS I  495  1                                  17    
HELIX  146 AQ2 MET I  496  MET I  504  1                                   9    
HELIX  147 AQ3 SER I  506  GLY I  518  1                                  13    
HELIX  148 AQ4 ALA I  520  LEU I  533  1                                  14    
HELIX  149 AQ5 ASP I  534  LEU I  550  1                                  17    
HELIX  150 AQ6 LEU I  550  LEU I  555  1                                   6    
HELIX  151 AQ7 ASN I  562  GLY I  567  1                                   6    
HELIX  152 AQ8 THR I  573  GLY I  591  1                                  19    
HELIX  153 AQ9 ASN I  599  ILE I  603  5                                   5    
HELIX  154 AR1 PRO I  850  ASN I  852  5                                   3    
HELIX  155 AR2 THR I  911  LYS I  916  1                                   6    
HELIX  156 AR3 ASP J    2  CYS J   14  1                                  13    
HELIX  157 AR4 THR J   49  LYS J   55  1                                   7    
HELIX  158 AR5 LYS J   60  ASN J   70  1                                  11    
HELIX  159 AR6 ASN J   70  ILE J   75  1                                   6    
HELIX  160 AR7 LYS J   87  THR J  102  1                                  16    
HELIX  161 AR8 THR K  107  GLY K  118  1                                  12    
HELIX  162 AR9 ARG K  129  LEU K  143  1                                  15    
HELIX  163 AS1 GLY K  159  ASP K  170  1                                  12    
HELIX  164 AS2 ASP K  170  PHE K  178  1                                   9    
HELIX  165 AS3 ASP K  191  ASP K  207  1                                  17    
HELIX  166 AS4 ASN K  219  ARG K  233  1                                  15    
HELIX  167 AS5 ASP K  247  ASP K  255  1                                   9    
HELIX  168 AS6 GLY K  287  ASN K  300  1                                  14    
HELIX  169 AS7 PRO K  307  LYS K  318  1                                  12    
HELIX  170 AS8 SER K  320  PHE K  334  1                                  15    
HELIX  171 AS9 ARG K  337  LYS K  348  1                                  12    
HELIX  172 AT1 ALA K  363  MET K  374  1                                  12    
HELIX  173 AT2 ARG K  376  LEU K  386  1                                  11    
HELIX  174 AT3 THR K  397  ASP K  405  1                                   9    
HELIX  175 AT4 GLU K  407  LYS K  421  1                                  15    
HELIX  176 AT5 HIS K  438  TYR K  467  1                                  30    
HELIX  177 AT6 ASP K  479  LYS K  495  1                                  17    
HELIX  178 AT7 MET K  496  MET K  504  1                                   9    
HELIX  179 AT8 SER K  506  GLY K  518  1                                  13    
HELIX  180 AT9 ALA K  520  LEU K  533  1                                  14    
HELIX  181 AU1 ASP K  534  LEU K  550  1                                  17    
HELIX  182 AU2 LEU K  550  LEU K  555  1                                   6    
HELIX  183 AU3 ASN K  562  GLY K  567  1                                   6    
HELIX  184 AU4 THR K  573  GLY K  591  1                                  19    
HELIX  185 AU5 ASN K  599  ILE K  603  5                                   5    
HELIX  186 AU6 PRO K  850  ASN K  852  5                                   3    
HELIX  187 AU7 THR K  911  LYS K  916  1                                   6    
HELIX  188 AU8 ASP L    2  CYS L   14  1                                  13    
HELIX  189 AU9 THR L   49  LYS L   55  1                                   7    
HELIX  190 AV1 LYS L   60  ASN L   70  1                                  11    
HELIX  191 AV2 ASN L   70  ILE L   75  1                                   6    
HELIX  192 AV3 LYS L   87  THR L  102  1                                  16    
HELIX  193 AV4 THR M  107  GLY M  118  1                                  12    
HELIX  194 AV5 ARG M  129  LEU M  143  1                                  15    
HELIX  195 AV6 GLY M  159  ASP M  170  1                                  12    
HELIX  196 AV7 ASP M  170  PHE M  178  1                                   9    
HELIX  197 AV8 ASP M  191  ASP M  207  1                                  17    
HELIX  198 AV9 ASN M  219  ARG M  233  1                                  15    
HELIX  199 AW1 ASP M  247  ASP M  255  1                                   9    
HELIX  200 AW2 GLY M  287  ASN M  300  1                                  14    
HELIX  201 AW3 PRO M  307  LYS M  318  1                                  12    
HELIX  202 AW4 SER M  320  PHE M  334  1                                  15    
HELIX  203 AW5 ARG M  337  LYS M  348  1                                  12    
HELIX  204 AW6 ALA M  363  MET M  374  1                                  12    
HELIX  205 AW7 ARG M  376  LEU M  386  1                                  11    
HELIX  206 AW8 THR M  397  ASP M  405  1                                   9    
HELIX  207 AW9 GLU M  407  LYS M  421  1                                  15    
HELIX  208 AX1 HIS M  438  TYR M  467  1                                  30    
HELIX  209 AX2 ASP M  479  LYS M  495  1                                  17    
HELIX  210 AX3 MET M  496  MET M  504  1                                   9    
HELIX  211 AX4 SER M  506  GLY M  518  1                                  13    
HELIX  212 AX5 ALA M  520  LEU M  533  1                                  14    
HELIX  213 AX6 ASP M  534  LEU M  550  1                                  17    
HELIX  214 AX7 LEU M  550  LEU M  555  1                                   6    
HELIX  215 AX8 ASN M  562  GLY M  567  1                                   6    
HELIX  216 AX9 THR M  573  GLY M  591  1                                  19    
HELIX  217 AY1 ASN M  599  ILE M  603  5                                   5    
HELIX  218 AY2 PRO M  850  ASN M  852  5                                   3    
HELIX  219 AY3 THR M  911  LYS M  916  1                                   6    
HELIX  220 AY4 ASP N    2  CYS N   14  1                                  13    
HELIX  221 AY5 THR N   49  LYS N   55  1                                   7    
HELIX  222 AY6 LYS N   60  ASN N   70  1                                  11    
HELIX  223 AY7 ASN N   70  ILE N   75  1                                   6    
HELIX  224 AY8 LYS N   87  THR N  102  1                                  16    
HELIX  225 AY9 ASP O    2  LYS O   18  1                                  17    
HELIX  226 AZ1 LYS O   21  ASP O   32  1                                  12    
HELIX  227 AZ2 THR O   36  ASN O   45  1                                  10    
HELIX  228 AZ3 THR O   48  LEU O   61  1                                  14    
HELIX  229 AZ4 ASP O   64  GLU O   78  1                                  15    
HELIX  230 AZ5 TYR O   80  HIS O   88  1                                   9    
HELIX  231 AZ6 ASP O   89  ILE O   91  5                                   3    
HELIX  232 AZ7 ASP P    2  LYS P   18  1                                  17    
HELIX  233 AZ8 LYS P   21  ASP P   32  1                                  12    
HELIX  234 AZ9 THR P   36  ASN P   45  1                                  10    
HELIX  235 BA1 THR P   48  LYS P   62  1                                  15    
HELIX  236 BA2 ASP P   64  GLU P   78  1                                  15    
HELIX  237 BA3 TYR P   80  HIS P   88  1                                   9    
HELIX  238 BA4 ASP P   89  ILE P   91  5                                   3    
HELIX  239 BA5 ASP Q    2  LYS Q   18  1                                  17    
HELIX  240 BA6 LYS Q   21  GLY Q   33  1                                  13    
HELIX  241 BA7 THR Q   36  ASN Q   45  1                                  10    
HELIX  242 BA8 THR Q   48  LYS Q   62  1                                  15    
HELIX  243 BA9 ASP Q   64  GLU Q   78  1                                  15    
HELIX  244 BB1 TYR Q   80  HIS Q   88  1                                   9    
HELIX  245 BB2 ASP Q   89  ILE Q   91  5                                   3    
HELIX  246 BB3 ASP R    2  LYS R   18  1                                  17    
HELIX  247 BB4 LYS R   21  ASP R   32  1                                  12    
HELIX  248 BB5 THR R   36  ASN R   45  1                                  10    
HELIX  249 BB6 THR R   48  LYS R   62  1                                  15    
HELIX  250 BB7 ASP R   64  GLU R   78  1                                  15    
HELIX  251 BB8 TYR R   80  HIS R   88  1                                   9    
HELIX  252 BB9 ASP R   89  ILE R   91  5                                   3    
HELIX  253 BC1 ASP S    2  CYS S   12  1                                  11    
HELIX  254 BC2 CYS S   12  LEU S   20  1                                   9    
HELIX  255 BC3 LEU S   25  ARG S   32  1                                   8    
HELIX  256 BC4 ARG S   36  ARG S   45  1                                  10    
HELIX  257 BC5 SER S   50  GLU S   63  1                                  14    
HELIX  258 BC6 GLN S   68  ASP S   79  1                                  12    
HELIX  259 BC7 GLN S   82  ALA S   95  1                                  14    
HELIX  260 BC8 ASP T    2  CYS T   12  1                                  11    
HELIX  261 BC9 CYS T   12  LEU T   20  1                                   9    
HELIX  262 BD1 LEU T   25  ARG T   32  1                                   8    
HELIX  263 BD2 ARG T   36  ARG T   45  1                                  10    
HELIX  264 BD3 SER T   50  GLU T   63  1                                  14    
HELIX  265 BD4 GLN T   68  ASP T   79  1                                  12    
HELIX  266 BD5 GLN T   82  ALA T   95  1                                  14    
HELIX  267 BD6 ASP U    2  CYS U   12  1                                  11    
HELIX  268 BD7 CYS U   12  GLU U   18  1                                   7    
HELIX  269 BD8 LEU U   25  ARG U   32  1                                   8    
HELIX  270 BD9 ARG U   36  ARG U   45  1                                  10    
HELIX  271 BE1 SER U   50  GLU U   63  1                                  14    
HELIX  272 BE2 GLN U   68  ASP U   79  1                                  12    
HELIX  273 BE3 GLN U   82  ALA U   95  1                                  14    
HELIX  274 BE4 ASP V    2  CYS V   12  1                                  11    
HELIX  275 BE5 CYS V   12  LEU V   20  1                                   9    
HELIX  276 BE6 LEU V   25  ARG V   32  1                                   8    
HELIX  277 BE7 ARG V   36  ARG V   45  1                                  10    
HELIX  278 BE8 SER V   50  GLU V   63  1                                  14    
HELIX  279 BE9 GLN V   68  ASP V   79  1                                  12    
HELIX  280 BF1 GLN V   82  ALA V   95  1                                  14    
HELIX  281 BF2 ASP W    2  HIS W   12  1                                  11    
HELIX  282 BF3 HIS W   12  ILE W   20  1                                   9    
HELIX  283 BF4 LYS W   21  TYR W   24  5                                   4    
HELIX  284 BF5 ILE W   25  ASP W   32  1                                   8    
HELIX  285 BF6 THR W   36  ASN W   45  1                                  10    
HELIX  286 BF7 THR W   48  LEU W   61  1                                  14    
HELIX  287 BF8 ASP W   64  GLU W   78  1                                  15    
HELIX  288 BF9 TYR W   80  ASP W   89  1                                  10    
HELIX  289 BG1 ASP X    2  ILE X   20  1                                  19    
HELIX  290 BG2 LYS X   21  GLY X   33  1                                  13    
HELIX  291 BG3 THR X   36  GLU X   46  1                                  11    
HELIX  292 BG4 THR X   48  LYS X   62  1                                  15    
HELIX  293 BG5 ASP X   64  GLU X   78  1                                  15    
HELIX  294 BG6 TYR X   80  ASP X   89  1                                  10    
HELIX  295 BG7 ASP Y    2  CYS Y   12  1                                  11    
HELIX  296 BG8 CYS Y   12  LEU Y   20  1                                   9    
HELIX  297 BG9 LEU Y   25  ARG Y   32  1                                   8    
HELIX  298 BH1 ARG Y   36  ARG Y   45  1                                  10    
HELIX  299 BH2 SER Y   50  GLU Y   63  1                                  14    
HELIX  300 BH3 GLN Y   68  THR Y   80  1                                  13    
HELIX  301 BH4 GLN Y   82  GLN Y   94  1                                  13    
SHEET    1 AA1 5 VAL A 182  GLY A 188  0                                        
SHEET    2 AA1 5 LEU A 239  ASP A 244  1  O  ILE A 241   N  VAL A 185           
SHEET    3 AA1 5 ILE A 260  THR A 264  1  O  LEU A 261   N  LEU A 240           
SHEET    4 AA1 5 TRP A 149  HIS A 153  1  N  ILE A 152   O  THR A 264           
SHEET    5 AA1 5 LYS A 277  PRO A 281  1  O  TYR A 278   N  THR A 151           
SHEET    1 AA2 2 VAL A 395  PRO A 396  0                                        
SHEET    2 AA2 2 ARG A 434  TYR A 435 -1  O  TYR A 435   N  VAL A 395           
SHEET    1 AA3 4 LEU A 609  VAL A 611  0                                        
SHEET    2 AA3 4 ILE A 906  GLU A 910 -1  O  ILE A 906   N  VAL A 611           
SHEET    3 AA3 4 SER A 896  SER A 901 -1  N  PHE A 897   O  TRP A 909           
SHEET    4 AA3 4 VAL A 885  PHE A 890 -1  N  GLY A 887   O  SER A 900           
SHEET    1 AA4 4 ALA A 621  PHE A 623  0                                        
SHEET    2 AA4 4 ILE A 630  SER A 632 -1  O  ALA A 631   N  CYS A 622           
SHEET    3 AA4 4 GLN A 640  LYS A 643 -1  O  PHE A 642   N  ILE A 630           
SHEET    4 AA4 4 GLU A 648  GLU A 652 -1  O  LEU A 650   N  VAL A 641           
SHEET    1 AA5 4 VAL A 660  PHE A 665  0                                        
SHEET    2 AA5 4 PHE A 671  SER A 676 -1  O  CYS A 675   N  CYS A 662           
SHEET    3 AA5 4 VAL A 681  ASN A 685 -1  O  TRP A 684   N  ILE A 672           
SHEET    4 AA5 4 LEU A 691  TYR A 695 -1  O  TYR A 695   N  VAL A 681           
SHEET    1 AA6 4 VAL A 702  PHE A 707  0                                        
SHEET    2 AA6 4 LEU A 715  SER A 720 -1  O  GLY A 719   N  ASN A 703           
SHEET    3 AA6 4 LEU A 725  ASP A 729 -1  O  TRP A 728   N  LEU A 716           
SHEET    4 AA6 4 CYS A 735  MET A 739 -1  O  ASN A 737   N  LEU A 727           
SHEET    1 AA7 4 VAL A 746  CYS A 749  0                                        
SHEET    2 AA7 4 LEU A 757  SER A 762 -1  O  CYS A 761   N  HIS A 748           
SHEET    3 AA7 4 LYS A 768  ASP A 771 -1  O  TRP A 770   N  LEU A 758           
SHEET    4 AA7 4 ASN A 776  LYS A 779 -1  O  LYS A 779   N  LEU A 769           
SHEET    1 AA8 4 CYS A 804  TRP A 806  0                                        
SHEET    2 AA8 4 ILE A 813  ALA A 817 -1  O  MET A 814   N  SER A 805           
SHEET    3 AA8 4 LYS A 820  ASP A 825 -1  O  PHE A 822   N  VAL A 815           
SHEET    4 AA8 4 GLY A 830  GLY A 833 -1  O  GLY A 830   N  ASP A 825           
SHEET    1 AA9 3 LEU A 854  ALA A 858  0                                        
SHEET    2 AA9 3 VAL A 864  ASN A 868 -1  O  TRP A 867   N  ALA A 855           
SHEET    3 AA9 3 SER A 873  ALA A 876 -1  O  VAL A 875   N  LEU A 866           
SHEET    1 AB1 3 VAL A 928  PHE A 930  0                                        
SHEET    2 AB1 3 VAL A 935  VAL A 937 -1  O  MET A 936   N  VAL A 929           
SHEET    3 AB1 3 ILE A 949  ASN A 950 -1  O  ILE A 949   N  VAL A 937           
SHEET    1 AB2 2 LEU A 946  GLN A 947  0                                        
SHEET    2 AB2 2 TYR A 958  LEU A 959 -1  O  LEU A 959   N  LEU A 946           
SHEET    1 AB3 2 CYS A 967  LEU A 969  0                                        
SHEET    2 AB3 2 ILE A 976  PHE A 978 -1  O  ALA A 977   N  CYS A 968           
SHEET    1 AB4 2 ILE A 985  GLU A 986  0                                        
SHEET    2 AB4 2 SER A 998  ARG A 999 -1  O  ARG A 999   N  ILE A 985           
SHEET    1 AB5 4 ILE A1009  PHE A1011  0                                        
SHEET    2 AB5 4 LEU A1018  SER A1020 -1  O  ILE A1019   N  GLN A1010           
SHEET    3 AB5 4 ILE A1027  ASN A1031 -1  O  GLN A1028   N  SER A1020           
SHEET    4 AB5 4 LYS A1036  LEU A1040 -1  O  LEU A1040   N  ILE A1027           
SHEET    1 AB6 4 ASP A1049  LEU A1052  0                                        
SHEET    2 AB6 4 ARG A1057  TRP A1061 -1  O  TRP A1061   N  ASP A1049           
SHEET    3 AB6 4 VAL A1067  ASN A1071 -1  O  TRP A1070   N  LEU A1058           
SHEET    4 AB6 4 LYS A1079  PHE A1081 -1  O  PHE A1081   N  VAL A1067           
SHEET    1 AB7 4 SER A1090  ILE A1093  0                                        
SHEET    2 AB7 4 SER A1101  SER A1104 -1  O  SER A1102   N  ASP A1092           
SHEET    3 AB7 4 ALA A1109  TRP A1112 -1  O  TRP A1112   N  SER A1101           
SHEET    4 AB7 4 HIS A1121  LEU A1123 -1  O  HIS A1121   N  ILE A1111           
SHEET    1 AB8 2 CYS A1132  PHE A1135  0                                        
SHEET    2 AB8 2 LEU A1142  GLY A1145 -1  O  GLY A1145   N  CYS A1132           
SHEET    1 AB9 3 ASP A1182  PHE A1185  0                                        
SHEET    2 AB9 3 MET A1191  ALA A1195 -1  O  ILE A1193   N  CYS A1184           
SHEET    3 AB9 3 ILE A1199  ASN A1203 -1  O  TRP A1202   N  LEU A1192           
SHEET    1 AC1 2 VAL A1233  VAL A1235  0                                        
SHEET    2 AC1 2 LEU A1241  ILE A1243 -1  O  TYR A1242   N  THR A1234           
SHEET    1 AC2 5 VAL C 182  GLY C 188  0                                        
SHEET    2 AC2 5 LEU C 239  ASP C 244  1  O  ILE C 241   N  VAL C 185           
SHEET    3 AC2 5 ILE C 260  THR C 264  1  O  LEU C 261   N  LEU C 240           
SHEET    4 AC2 5 TRP C 149  HIS C 153  1  N  ILE C 152   O  THR C 264           
SHEET    5 AC2 5 LYS C 277  PRO C 281  1  O  TYR C 278   N  THR C 151           
SHEET    1 AC3 2 VAL C 395  PRO C 396  0                                        
SHEET    2 AC3 2 ARG C 434  TYR C 435 -1  O  TYR C 435   N  VAL C 395           
SHEET    1 AC4 4 LEU C 609  VAL C 611  0                                        
SHEET    2 AC4 4 ILE C 906  GLU C 910 -1  O  ILE C 906   N  VAL C 611           
SHEET    3 AC4 4 SER C 896  SER C 901 -1  N  PHE C 897   O  TRP C 909           
SHEET    4 AC4 4 VAL C 885  PHE C 890 -1  N  GLY C 887   O  SER C 900           
SHEET    1 AC5 4 ALA C 621  PHE C 623  0                                        
SHEET    2 AC5 4 ILE C 630  SER C 632 -1  O  ALA C 631   N  CYS C 622           
SHEET    3 AC5 4 GLN C 640  LYS C 643 -1  O  PHE C 642   N  ILE C 630           
SHEET    4 AC5 4 GLU C 648  GLU C 652 -1  O  LEU C 650   N  VAL C 641           
SHEET    1 AC6 4 VAL C 660  PHE C 665  0                                        
SHEET    2 AC6 4 PHE C 671  SER C 676 -1  O  CYS C 675   N  CYS C 662           
SHEET    3 AC6 4 VAL C 681  ASN C 685 -1  O  TRP C 684   N  ILE C 672           
SHEET    4 AC6 4 LEU C 691  TYR C 695 -1  O  TYR C 695   N  VAL C 681           
SHEET    1 AC7 4 VAL C 702  PHE C 707  0                                        
SHEET    2 AC7 4 LEU C 715  SER C 720 -1  O  GLY C 719   N  ASN C 703           
SHEET    3 AC7 4 LEU C 725  ASP C 729 -1  O  TRP C 728   N  LEU C 716           
SHEET    4 AC7 4 CYS C 735  MET C 739 -1  O  ASN C 737   N  LEU C 727           
SHEET    1 AC8 4 VAL C 746  CYS C 749  0                                        
SHEET    2 AC8 4 LEU C 757  SER C 762 -1  O  CYS C 761   N  HIS C 748           
SHEET    3 AC8 4 LYS C 768  ASP C 771 -1  O  TRP C 770   N  LEU C 758           
SHEET    4 AC8 4 ASN C 776  LYS C 779 -1  O  LYS C 779   N  LEU C 769           
SHEET    1 AC9 4 CYS C 804  TRP C 806  0                                        
SHEET    2 AC9 4 ILE C 813  ALA C 817 -1  O  MET C 814   N  SER C 805           
SHEET    3 AC9 4 LYS C 820  ASP C 825 -1  O  PHE C 822   N  VAL C 815           
SHEET    4 AC9 4 GLY C 830  GLY C 833 -1  O  GLY C 830   N  ASP C 825           
SHEET    1 AD1 3 LEU C 854  ALA C 858  0                                        
SHEET    2 AD1 3 VAL C 864  ASN C 868 -1  O  TRP C 867   N  ALA C 855           
SHEET    3 AD1 3 SER C 873  ALA C 876 -1  O  VAL C 875   N  LEU C 866           
SHEET    1 AD2 3 VAL C 928  PHE C 930  0                                        
SHEET    2 AD2 3 VAL C 935  VAL C 937 -1  O  MET C 936   N  VAL C 929           
SHEET    3 AD2 3 ILE C 949  ASN C 950 -1  O  ILE C 949   N  VAL C 937           
SHEET    1 AD3 2 LEU C 946  GLN C 947  0                                        
SHEET    2 AD3 2 TYR C 958  LEU C 959 -1  O  LEU C 959   N  LEU C 946           
SHEET    1 AD4 2 CYS C 967  LEU C 969  0                                        
SHEET    2 AD4 2 ILE C 976  PHE C 978 -1  O  ALA C 977   N  CYS C 968           
SHEET    1 AD5 2 ILE C 985  GLU C 986  0                                        
SHEET    2 AD5 2 SER C 998  ARG C 999 -1  O  ARG C 999   N  ILE C 985           
SHEET    1 AD6 4 ILE C1009  PHE C1011  0                                        
SHEET    2 AD6 4 LEU C1018  SER C1020 -1  O  ILE C1019   N  GLN C1010           
SHEET    3 AD6 4 ILE C1027  ASN C1031 -1  O  GLN C1028   N  SER C1020           
SHEET    4 AD6 4 LYS C1036  LEU C1040 -1  O  LEU C1040   N  ILE C1027           
SHEET    1 AD7 4 ASP C1049  LEU C1052  0                                        
SHEET    2 AD7 4 ARG C1057  TRP C1061 -1  O  TRP C1061   N  ASP C1049           
SHEET    3 AD7 4 VAL C1067  ASN C1071 -1  O  TRP C1070   N  LEU C1058           
SHEET    4 AD7 4 LYS C1079  PHE C1081 -1  O  PHE C1081   N  VAL C1067           
SHEET    1 AD8 4 SER C1090  ILE C1093  0                                        
SHEET    2 AD8 4 SER C1101  SER C1104 -1  O  SER C1102   N  ASP C1092           
SHEET    3 AD8 4 ALA C1109  TRP C1112 -1  O  TRP C1112   N  SER C1101           
SHEET    4 AD8 4 HIS C1121  LEU C1123 -1  O  HIS C1121   N  ILE C1111           
SHEET    1 AD9 2 CYS C1132  PHE C1135  0                                        
SHEET    2 AD9 2 LEU C1142  GLY C1145 -1  O  GLY C1145   N  CYS C1132           
SHEET    1 AE1 3 ASP C1182  PHE C1185  0                                        
SHEET    2 AE1 3 MET C1191  ALA C1195 -1  O  ILE C1193   N  CYS C1184           
SHEET    3 AE1 3 ILE C1199  ASN C1203 -1  O  TRP C1202   N  LEU C1192           
SHEET    1 AE2 2 VAL C1233  VAL C1235  0                                        
SHEET    2 AE2 2 LEU C1241  ILE C1243 -1  O  TYR C1242   N  THR C1234           
SHEET    1 AE3 5 VAL E 182  GLY E 188  0                                        
SHEET    2 AE3 5 LEU E 239  ASP E 244  1  O  ILE E 241   N  VAL E 185           
SHEET    3 AE3 5 ILE E 260  THR E 264  1  O  LEU E 261   N  LEU E 240           
SHEET    4 AE3 5 TRP E 149  HIS E 153  1  N  ILE E 152   O  THR E 264           
SHEET    5 AE3 5 LYS E 277  PRO E 281  1  O  TYR E 278   N  THR E 151           
SHEET    1 AE4 2 VAL E 395  PRO E 396  0                                        
SHEET    2 AE4 2 ARG E 434  TYR E 435 -1  O  TYR E 435   N  VAL E 395           
SHEET    1 AE5 4 LEU E 609  VAL E 611  0                                        
SHEET    2 AE5 4 ILE E 906  GLU E 910 -1  O  ILE E 906   N  VAL E 611           
SHEET    3 AE5 4 SER E 896  SER E 901 -1  N  PHE E 897   O  TRP E 909           
SHEET    4 AE5 4 VAL E 885  PHE E 890 -1  N  GLY E 887   O  SER E 900           
SHEET    1 AE6 4 ALA E 621  PHE E 623  0                                        
SHEET    2 AE6 4 ILE E 630  SER E 632 -1  O  ALA E 631   N  CYS E 622           
SHEET    3 AE6 4 GLN E 640  LYS E 643 -1  O  PHE E 642   N  ILE E 630           
SHEET    4 AE6 4 GLU E 648  GLU E 652 -1  O  LEU E 650   N  VAL E 641           
SHEET    1 AE7 4 VAL E 660  PHE E 665  0                                        
SHEET    2 AE7 4 PHE E 671  SER E 676 -1  O  CYS E 675   N  CYS E 662           
SHEET    3 AE7 4 VAL E 681  ASN E 685 -1  O  TRP E 684   N  ILE E 672           
SHEET    4 AE7 4 LEU E 691  TYR E 695 -1  O  TYR E 695   N  VAL E 681           
SHEET    1 AE8 4 VAL E 702  PHE E 707  0                                        
SHEET    2 AE8 4 LEU E 715  SER E 720 -1  O  GLY E 719   N  ASN E 703           
SHEET    3 AE8 4 LEU E 725  ASP E 729 -1  O  TRP E 728   N  LEU E 716           
SHEET    4 AE8 4 CYS E 735  MET E 739 -1  O  ASN E 737   N  LEU E 727           
SHEET    1 AE9 4 VAL E 746  CYS E 749  0                                        
SHEET    2 AE9 4 LEU E 757  SER E 762 -1  O  CYS E 761   N  HIS E 748           
SHEET    3 AE9 4 LYS E 768  ASP E 771 -1  O  TRP E 770   N  LEU E 758           
SHEET    4 AE9 4 ASN E 776  LYS E 779 -1  O  LYS E 779   N  LEU E 769           
SHEET    1 AF1 4 CYS E 804  TRP E 806  0                                        
SHEET    2 AF1 4 ILE E 813  ALA E 817 -1  O  MET E 814   N  SER E 805           
SHEET    3 AF1 4 LYS E 820  ASP E 825 -1  O  PHE E 822   N  VAL E 815           
SHEET    4 AF1 4 GLY E 830  GLY E 833 -1  O  GLY E 830   N  ASP E 825           
SHEET    1 AF2 3 LEU E 854  ALA E 858  0                                        
SHEET    2 AF2 3 VAL E 864  ASN E 868 -1  O  TRP E 867   N  ALA E 855           
SHEET    3 AF2 3 SER E 873  ALA E 876 -1  O  VAL E 875   N  LEU E 866           
SHEET    1 AF3 3 VAL E 928  PHE E 930  0                                        
SHEET    2 AF3 3 VAL E 935  VAL E 937 -1  O  MET E 936   N  VAL E 929           
SHEET    3 AF3 3 ILE E 949  ASN E 950 -1  O  ILE E 949   N  VAL E 937           
SHEET    1 AF4 2 LEU E 946  GLN E 947  0                                        
SHEET    2 AF4 2 TYR E 958  LEU E 959 -1  O  LEU E 959   N  LEU E 946           
SHEET    1 AF5 2 CYS E 967  LEU E 969  0                                        
SHEET    2 AF5 2 ILE E 976  PHE E 978 -1  O  ALA E 977   N  CYS E 968           
SHEET    1 AF6 2 ILE E 985  GLU E 986  0                                        
SHEET    2 AF6 2 SER E 998  ARG E 999 -1  O  ARG E 999   N  ILE E 985           
SHEET    1 AF7 4 ILE E1009  PHE E1011  0                                        
SHEET    2 AF7 4 LEU E1018  SER E1020 -1  O  ILE E1019   N  GLN E1010           
SHEET    3 AF7 4 ILE E1027  ASN E1031 -1  O  GLN E1028   N  SER E1020           
SHEET    4 AF7 4 LYS E1036  LEU E1040 -1  O  LEU E1040   N  ILE E1027           
SHEET    1 AF8 4 ASP E1049  LEU E1052  0                                        
SHEET    2 AF8 4 ARG E1057  TRP E1061 -1  O  TRP E1061   N  ASP E1049           
SHEET    3 AF8 4 VAL E1067  ASN E1071 -1  O  TRP E1070   N  LEU E1058           
SHEET    4 AF8 4 LYS E1079  PHE E1081 -1  O  PHE E1081   N  VAL E1067           
SHEET    1 AF9 4 SER E1090  ILE E1093  0                                        
SHEET    2 AF9 4 SER E1101  SER E1104 -1  O  SER E1102   N  ASP E1092           
SHEET    3 AF9 4 ALA E1109  TRP E1112 -1  O  TRP E1112   N  SER E1101           
SHEET    4 AF9 4 HIS E1121  LEU E1123 -1  O  HIS E1121   N  ILE E1111           
SHEET    1 AG1 2 CYS E1132  PHE E1135  0                                        
SHEET    2 AG1 2 LEU E1142  GLY E1145 -1  O  GLY E1145   N  CYS E1132           
SHEET    1 AG2 3 ASP E1182  PHE E1185  0                                        
SHEET    2 AG2 3 MET E1191  ALA E1195 -1  O  ILE E1193   N  CYS E1184           
SHEET    3 AG2 3 ILE E1199  ASN E1203 -1  O  TRP E1202   N  LEU E1192           
SHEET    1 AG3 2 VAL E1233  VAL E1235  0                                        
SHEET    2 AG3 2 LEU E1241  ILE E1243 -1  O  TYR E1242   N  THR E1234           
SHEET    1 AG4 5 VAL G 182  GLY G 188  0                                        
SHEET    2 AG4 5 LEU G 239  ASP G 244  1  O  ILE G 241   N  VAL G 185           
SHEET    3 AG4 5 ILE G 260  THR G 264  1  O  LEU G 261   N  LEU G 240           
SHEET    4 AG4 5 TRP G 149  HIS G 153  1  N  ILE G 152   O  THR G 264           
SHEET    5 AG4 5 LYS G 277  PRO G 281  1  O  TYR G 278   N  THR G 151           
SHEET    1 AG5 2 VAL G 395  PRO G 396  0                                        
SHEET    2 AG5 2 ARG G 434  TYR G 435 -1  O  TYR G 435   N  VAL G 395           
SHEET    1 AG6 4 LEU G 609  VAL G 611  0                                        
SHEET    2 AG6 4 ILE G 906  GLU G 910 -1  O  ILE G 906   N  VAL G 611           
SHEET    3 AG6 4 SER G 896  SER G 901 -1  N  PHE G 897   O  TRP G 909           
SHEET    4 AG6 4 VAL G 885  PHE G 890 -1  N  GLY G 887   O  SER G 900           
SHEET    1 AG7 4 ALA G 621  PHE G 623  0                                        
SHEET    2 AG7 4 ILE G 630  SER G 632 -1  O  ALA G 631   N  CYS G 622           
SHEET    3 AG7 4 GLN G 640  LYS G 643 -1  O  PHE G 642   N  ILE G 630           
SHEET    4 AG7 4 GLU G 648  GLU G 652 -1  O  LEU G 650   N  VAL G 641           
SHEET    1 AG8 4 VAL G 660  PHE G 665  0                                        
SHEET    2 AG8 4 PHE G 671  SER G 676 -1  O  CYS G 675   N  CYS G 662           
SHEET    3 AG8 4 VAL G 681  ASN G 685 -1  O  TRP G 684   N  ILE G 672           
SHEET    4 AG8 4 LEU G 691  TYR G 695 -1  O  TYR G 695   N  VAL G 681           
SHEET    1 AG9 4 VAL G 702  PHE G 707  0                                        
SHEET    2 AG9 4 LEU G 715  SER G 720 -1  O  GLY G 719   N  ASN G 703           
SHEET    3 AG9 4 LEU G 725  ASP G 729 -1  O  TRP G 728   N  LEU G 716           
SHEET    4 AG9 4 CYS G 735  MET G 739 -1  O  ASN G 737   N  LEU G 727           
SHEET    1 AH1 4 VAL G 746  CYS G 749  0                                        
SHEET    2 AH1 4 LEU G 757  SER G 762 -1  O  CYS G 761   N  HIS G 748           
SHEET    3 AH1 4 LYS G 768  ASP G 771 -1  O  TRP G 770   N  LEU G 758           
SHEET    4 AH1 4 ASN G 776  LYS G 779 -1  O  LYS G 779   N  LEU G 769           
SHEET    1 AH2 4 CYS G 804  TRP G 806  0                                        
SHEET    2 AH2 4 ILE G 813  ALA G 817 -1  O  MET G 814   N  SER G 805           
SHEET    3 AH2 4 LYS G 820  ASP G 825 -1  O  PHE G 822   N  VAL G 815           
SHEET    4 AH2 4 GLY G 830  GLY G 833 -1  O  GLY G 830   N  ASP G 825           
SHEET    1 AH3 3 LEU G 854  ALA G 858  0                                        
SHEET    2 AH3 3 VAL G 864  ASN G 868 -1  O  TRP G 867   N  ALA G 855           
SHEET    3 AH3 3 SER G 873  ALA G 876 -1  O  VAL G 875   N  LEU G 866           
SHEET    1 AH4 3 VAL G 928  PHE G 930  0                                        
SHEET    2 AH4 3 VAL G 935  VAL G 937 -1  O  MET G 936   N  VAL G 929           
SHEET    3 AH4 3 ILE G 949  ASN G 950 -1  O  ILE G 949   N  VAL G 937           
SHEET    1 AH5 2 LEU G 946  GLN G 947  0                                        
SHEET    2 AH5 2 TYR G 958  LEU G 959 -1  O  LEU G 959   N  LEU G 946           
SHEET    1 AH6 2 CYS G 967  LEU G 969  0                                        
SHEET    2 AH6 2 ILE G 976  PHE G 978 -1  O  ALA G 977   N  CYS G 968           
SHEET    1 AH7 2 ILE G 985  GLU G 986  0                                        
SHEET    2 AH7 2 SER G 998  ARG G 999 -1  O  ARG G 999   N  ILE G 985           
SHEET    1 AH8 4 ILE G1009  PHE G1011  0                                        
SHEET    2 AH8 4 LEU G1018  SER G1020 -1  O  ILE G1019   N  GLN G1010           
SHEET    3 AH8 4 ILE G1027  ASN G1031 -1  O  GLN G1028   N  SER G1020           
SHEET    4 AH8 4 LYS G1036  LEU G1040 -1  O  LEU G1040   N  ILE G1027           
SHEET    1 AH9 4 ASP G1049  LEU G1052  0                                        
SHEET    2 AH9 4 ARG G1057  TRP G1061 -1  O  TRP G1061   N  ASP G1049           
SHEET    3 AH9 4 VAL G1067  ASN G1071 -1  O  TRP G1070   N  LEU G1058           
SHEET    4 AH9 4 LYS G1079  PHE G1081 -1  O  PHE G1081   N  VAL G1067           
SHEET    1 AI1 4 SER G1090  ILE G1093  0                                        
SHEET    2 AI1 4 SER G1101  SER G1104 -1  O  SER G1102   N  ASP G1092           
SHEET    3 AI1 4 ALA G1109  TRP G1112 -1  O  TRP G1112   N  SER G1101           
SHEET    4 AI1 4 HIS G1121  LEU G1123 -1  O  HIS G1121   N  ILE G1111           
SHEET    1 AI2 2 CYS G1132  PHE G1135  0                                        
SHEET    2 AI2 2 LEU G1142  GLY G1145 -1  O  GLY G1145   N  CYS G1132           
SHEET    1 AI3 3 ASP G1182  PHE G1185  0                                        
SHEET    2 AI3 3 MET G1191  ALA G1195 -1  O  ILE G1193   N  CYS G1184           
SHEET    3 AI3 3 ILE G1199  ASN G1203 -1  O  TRP G1202   N  LEU G1192           
SHEET    1 AI4 2 VAL G1233  VAL G1235  0                                        
SHEET    2 AI4 2 LEU G1241  ILE G1243 -1  O  TYR G1242   N  THR G1234           
SHEET    1 AI5 5 VAL I 182  GLY I 188  0                                        
SHEET    2 AI5 5 LEU I 239  ASP I 244  1  O  ILE I 241   N  VAL I 185           
SHEET    3 AI5 5 ILE I 260  THR I 264  1  O  LEU I 261   N  LEU I 240           
SHEET    4 AI5 5 TRP I 149  HIS I 153  1  N  ILE I 152   O  THR I 264           
SHEET    5 AI5 5 LYS I 277  PRO I 281  1  O  TYR I 278   N  THR I 151           
SHEET    1 AI6 2 VAL I 395  PRO I 396  0                                        
SHEET    2 AI6 2 ARG I 434  TYR I 435 -1  O  TYR I 435   N  VAL I 395           
SHEET    1 AI7 4 LEU I 609  VAL I 611  0                                        
SHEET    2 AI7 4 ILE I 906  GLU I 910 -1  O  ILE I 906   N  VAL I 611           
SHEET    3 AI7 4 SER I 896  SER I 901 -1  N  PHE I 897   O  TRP I 909           
SHEET    4 AI7 4 VAL I 885  PHE I 890 -1  N  GLY I 887   O  SER I 900           
SHEET    1 AI8 4 ALA I 621  PHE I 623  0                                        
SHEET    2 AI8 4 ILE I 630  SER I 632 -1  O  ALA I 631   N  CYS I 622           
SHEET    3 AI8 4 GLN I 640  LYS I 643 -1  O  PHE I 642   N  ILE I 630           
SHEET    4 AI8 4 GLU I 648  GLU I 652 -1  O  LEU I 650   N  VAL I 641           
SHEET    1 AI9 4 VAL I 660  PHE I 665  0                                        
SHEET    2 AI9 4 PHE I 671  SER I 676 -1  O  CYS I 675   N  CYS I 662           
SHEET    3 AI9 4 VAL I 681  ASN I 685 -1  O  TRP I 684   N  ILE I 672           
SHEET    4 AI9 4 LEU I 691  TYR I 695 -1  O  TYR I 695   N  VAL I 681           
SHEET    1 AJ1 4 VAL I 702  PHE I 707  0                                        
SHEET    2 AJ1 4 LEU I 715  SER I 720 -1  O  GLY I 719   N  ASN I 703           
SHEET    3 AJ1 4 LEU I 725  ASP I 729 -1  O  TRP I 728   N  LEU I 716           
SHEET    4 AJ1 4 CYS I 735  MET I 739 -1  O  ASN I 737   N  LEU I 727           
SHEET    1 AJ2 4 VAL I 746  CYS I 749  0                                        
SHEET    2 AJ2 4 LEU I 757  SER I 762 -1  O  CYS I 761   N  HIS I 748           
SHEET    3 AJ2 4 LYS I 768  ASP I 771 -1  O  TRP I 770   N  LEU I 758           
SHEET    4 AJ2 4 ASN I 776  LYS I 779 -1  O  LYS I 779   N  LEU I 769           
SHEET    1 AJ3 4 CYS I 804  TRP I 806  0                                        
SHEET    2 AJ3 4 ILE I 813  ALA I 817 -1  O  MET I 814   N  SER I 805           
SHEET    3 AJ3 4 LYS I 820  ASP I 825 -1  O  PHE I 822   N  VAL I 815           
SHEET    4 AJ3 4 GLY I 830  GLY I 833 -1  O  GLY I 830   N  ASP I 825           
SHEET    1 AJ4 3 LEU I 854  ALA I 858  0                                        
SHEET    2 AJ4 3 VAL I 864  ASN I 868 -1  O  TRP I 867   N  ALA I 855           
SHEET    3 AJ4 3 SER I 873  ALA I 876 -1  O  VAL I 875   N  LEU I 866           
SHEET    1 AJ5 3 VAL I 928  PHE I 930  0                                        
SHEET    2 AJ5 3 VAL I 935  VAL I 937 -1  O  MET I 936   N  VAL I 929           
SHEET    3 AJ5 3 ILE I 949  ASN I 950 -1  O  ILE I 949   N  VAL I 937           
SHEET    1 AJ6 2 LEU I 946  GLN I 947  0                                        
SHEET    2 AJ6 2 TYR I 958  LEU I 959 -1  O  LEU I 959   N  LEU I 946           
SHEET    1 AJ7 2 CYS I 967  LEU I 969  0                                        
SHEET    2 AJ7 2 ILE I 976  PHE I 978 -1  O  ALA I 977   N  CYS I 968           
SHEET    1 AJ8 2 ILE I 985  GLU I 986  0                                        
SHEET    2 AJ8 2 SER I 998  ARG I 999 -1  O  ARG I 999   N  ILE I 985           
SHEET    1 AJ9 4 ILE I1009  PHE I1011  0                                        
SHEET    2 AJ9 4 LEU I1018  SER I1020 -1  O  ILE I1019   N  GLN I1010           
SHEET    3 AJ9 4 ILE I1027  ASN I1031 -1  O  GLN I1028   N  SER I1020           
SHEET    4 AJ9 4 LYS I1036  LEU I1040 -1  O  LEU I1040   N  ILE I1027           
SHEET    1 AK1 4 ASP I1049  LEU I1052  0                                        
SHEET    2 AK1 4 ARG I1057  TRP I1061 -1  O  TRP I1061   N  ASP I1049           
SHEET    3 AK1 4 VAL I1067  ASN I1071 -1  O  TRP I1070   N  LEU I1058           
SHEET    4 AK1 4 LYS I1079  PHE I1081 -1  O  PHE I1081   N  VAL I1067           
SHEET    1 AK2 4 SER I1090  ILE I1093  0                                        
SHEET    2 AK2 4 SER I1101  SER I1104 -1  O  SER I1102   N  ASP I1092           
SHEET    3 AK2 4 ALA I1109  TRP I1112 -1  O  TRP I1112   N  SER I1101           
SHEET    4 AK2 4 HIS I1121  LEU I1123 -1  O  HIS I1121   N  ILE I1111           
SHEET    1 AK3 2 CYS I1132  PHE I1135  0                                        
SHEET    2 AK3 2 LEU I1142  GLY I1145 -1  O  GLY I1145   N  CYS I1132           
SHEET    1 AK4 3 ASP I1182  PHE I1185  0                                        
SHEET    2 AK4 3 MET I1191  ALA I1195 -1  O  ILE I1193   N  CYS I1184           
SHEET    3 AK4 3 ILE I1199  ASN I1203 -1  O  TRP I1202   N  LEU I1192           
SHEET    1 AK5 2 VAL I1233  VAL I1235  0                                        
SHEET    2 AK5 2 LEU I1241  ILE I1243 -1  O  TYR I1242   N  THR I1234           
SHEET    1 AK6 5 VAL K 182  GLY K 188  0                                        
SHEET    2 AK6 5 LEU K 239  ASP K 244  1  O  ILE K 241   N  VAL K 185           
SHEET    3 AK6 5 ILE K 260  THR K 264  1  O  LEU K 261   N  LEU K 240           
SHEET    4 AK6 5 TRP K 149  HIS K 153  1  N  ILE K 152   O  THR K 264           
SHEET    5 AK6 5 LYS K 277  PRO K 281  1  O  TYR K 278   N  THR K 151           
SHEET    1 AK7 2 VAL K 395  PRO K 396  0                                        
SHEET    2 AK7 2 ARG K 434  TYR K 435 -1  O  TYR K 435   N  VAL K 395           
SHEET    1 AK8 4 LEU K 609  VAL K 611  0                                        
SHEET    2 AK8 4 ILE K 906  GLU K 910 -1  O  ILE K 906   N  VAL K 611           
SHEET    3 AK8 4 SER K 896  SER K 901 -1  N  PHE K 897   O  TRP K 909           
SHEET    4 AK8 4 VAL K 885  PHE K 890 -1  N  GLY K 887   O  SER K 900           
SHEET    1 AK9 4 ALA K 621  PHE K 623  0                                        
SHEET    2 AK9 4 ILE K 630  SER K 632 -1  O  ALA K 631   N  CYS K 622           
SHEET    3 AK9 4 GLN K 640  LYS K 643 -1  O  PHE K 642   N  ILE K 630           
SHEET    4 AK9 4 GLU K 648  GLU K 652 -1  O  LEU K 650   N  VAL K 641           
SHEET    1 AL1 4 VAL K 660  PHE K 665  0                                        
SHEET    2 AL1 4 PHE K 671  SER K 676 -1  O  CYS K 675   N  CYS K 662           
SHEET    3 AL1 4 VAL K 681  ASN K 685 -1  O  TRP K 684   N  ILE K 672           
SHEET    4 AL1 4 LEU K 691  TYR K 695 -1  O  TYR K 695   N  VAL K 681           
SHEET    1 AL2 4 VAL K 702  PHE K 707  0                                        
SHEET    2 AL2 4 LEU K 715  SER K 720 -1  O  GLY K 719   N  ASN K 703           
SHEET    3 AL2 4 LEU K 725  ASP K 729 -1  O  TRP K 728   N  LEU K 716           
SHEET    4 AL2 4 CYS K 735  MET K 739 -1  O  ASN K 737   N  LEU K 727           
SHEET    1 AL3 4 VAL K 746  CYS K 749  0                                        
SHEET    2 AL3 4 LEU K 757  SER K 762 -1  O  CYS K 761   N  HIS K 748           
SHEET    3 AL3 4 LYS K 768  ASP K 771 -1  O  TRP K 770   N  LEU K 758           
SHEET    4 AL3 4 ASN K 776  LYS K 779 -1  O  LYS K 779   N  LEU K 769           
SHEET    1 AL4 4 CYS K 804  TRP K 806  0                                        
SHEET    2 AL4 4 ILE K 813  ALA K 817 -1  O  MET K 814   N  SER K 805           
SHEET    3 AL4 4 LYS K 820  ASP K 825 -1  O  PHE K 822   N  VAL K 815           
SHEET    4 AL4 4 GLY K 830  GLY K 833 -1  O  GLY K 830   N  ASP K 825           
SHEET    1 AL5 3 LEU K 854  ALA K 858  0                                        
SHEET    2 AL5 3 VAL K 864  ASN K 868 -1  O  TRP K 867   N  ALA K 855           
SHEET    3 AL5 3 SER K 873  ALA K 876 -1  O  VAL K 875   N  LEU K 866           
SHEET    1 AL6 3 VAL K 928  PHE K 930  0                                        
SHEET    2 AL6 3 VAL K 935  VAL K 937 -1  O  MET K 936   N  VAL K 929           
SHEET    3 AL6 3 ILE K 949  ASN K 950 -1  O  ILE K 949   N  VAL K 937           
SHEET    1 AL7 2 LEU K 946  GLN K 947  0                                        
SHEET    2 AL7 2 TYR K 958  LEU K 959 -1  O  LEU K 959   N  LEU K 946           
SHEET    1 AL8 2 CYS K 967  LEU K 969  0                                        
SHEET    2 AL8 2 ILE K 976  PHE K 978 -1  O  ALA K 977   N  CYS K 968           
SHEET    1 AL9 2 ILE K 985  GLU K 986  0                                        
SHEET    2 AL9 2 SER K 998  ARG K 999 -1  O  ARG K 999   N  ILE K 985           
SHEET    1 AM1 4 ILE K1009  PHE K1011  0                                        
SHEET    2 AM1 4 LEU K1018  SER K1020 -1  O  ILE K1019   N  GLN K1010           
SHEET    3 AM1 4 ILE K1027  ASN K1031 -1  O  GLN K1028   N  SER K1020           
SHEET    4 AM1 4 LYS K1036  LEU K1040 -1  O  LEU K1040   N  ILE K1027           
SHEET    1 AM2 4 ASP K1049  LEU K1052  0                                        
SHEET    2 AM2 4 ARG K1057  TRP K1061 -1  O  TRP K1061   N  ASP K1049           
SHEET    3 AM2 4 VAL K1067  ASN K1071 -1  O  TRP K1070   N  LEU K1058           
SHEET    4 AM2 4 LYS K1079  PHE K1081 -1  O  PHE K1081   N  VAL K1067           
SHEET    1 AM3 4 SER K1090  ILE K1093  0                                        
SHEET    2 AM3 4 SER K1101  SER K1104 -1  O  SER K1102   N  ASP K1092           
SHEET    3 AM3 4 ALA K1109  TRP K1112 -1  O  TRP K1112   N  SER K1101           
SHEET    4 AM3 4 HIS K1121  LEU K1123 -1  O  HIS K1121   N  ILE K1111           
SHEET    1 AM4 2 CYS K1132  PHE K1135  0                                        
SHEET    2 AM4 2 LEU K1142  GLY K1145 -1  O  GLY K1145   N  CYS K1132           
SHEET    1 AM5 3 ASP K1182  PHE K1185  0                                        
SHEET    2 AM5 3 MET K1191  ALA K1195 -1  O  ILE K1193   N  CYS K1184           
SHEET    3 AM5 3 ILE K1199  ASN K1203 -1  O  TRP K1202   N  LEU K1192           
SHEET    1 AM6 2 VAL K1233  VAL K1235  0                                        
SHEET    2 AM6 2 LEU K1241  ILE K1243 -1  O  TYR K1242   N  THR K1234           
SHEET    1 AM7 5 VAL M 182  GLY M 188  0                                        
SHEET    2 AM7 5 LEU M 239  ASP M 244  1  O  ILE M 241   N  VAL M 185           
SHEET    3 AM7 5 ILE M 260  THR M 264  1  O  LEU M 261   N  LEU M 240           
SHEET    4 AM7 5 TRP M 149  HIS M 153  1  N  ILE M 152   O  THR M 264           
SHEET    5 AM7 5 LYS M 277  PRO M 281  1  O  TYR M 278   N  THR M 151           
SHEET    1 AM8 2 VAL M 395  PRO M 396  0                                        
SHEET    2 AM8 2 ARG M 434  TYR M 435 -1  O  TYR M 435   N  VAL M 395           
SHEET    1 AM9 4 LEU M 609  VAL M 611  0                                        
SHEET    2 AM9 4 ILE M 906  GLU M 910 -1  O  ILE M 906   N  VAL M 611           
SHEET    3 AM9 4 SER M 896  SER M 901 -1  N  PHE M 897   O  TRP M 909           
SHEET    4 AM9 4 VAL M 885  PHE M 890 -1  N  GLY M 887   O  SER M 900           
SHEET    1 AN1 4 ALA M 621  PHE M 623  0                                        
SHEET    2 AN1 4 ILE M 630  SER M 632 -1  O  ALA M 631   N  CYS M 622           
SHEET    3 AN1 4 GLN M 640  LYS M 643 -1  O  PHE M 642   N  ILE M 630           
SHEET    4 AN1 4 GLU M 648  GLU M 652 -1  O  LEU M 650   N  VAL M 641           
SHEET    1 AN2 4 VAL M 660  PHE M 665  0                                        
SHEET    2 AN2 4 PHE M 671  SER M 676 -1  O  CYS M 675   N  CYS M 662           
SHEET    3 AN2 4 VAL M 681  ASN M 685 -1  O  TRP M 684   N  ILE M 672           
SHEET    4 AN2 4 LEU M 691  TYR M 695 -1  O  TYR M 695   N  VAL M 681           
SHEET    1 AN3 4 VAL M 702  PHE M 707  0                                        
SHEET    2 AN3 4 LEU M 715  SER M 720 -1  O  GLY M 719   N  ASN M 703           
SHEET    3 AN3 4 LEU M 725  ASP M 729 -1  O  TRP M 728   N  LEU M 716           
SHEET    4 AN3 4 CYS M 735  MET M 739 -1  O  ASN M 737   N  LEU M 727           
SHEET    1 AN4 4 VAL M 746  CYS M 749  0                                        
SHEET    2 AN4 4 LEU M 757  SER M 762 -1  O  CYS M 761   N  HIS M 748           
SHEET    3 AN4 4 LYS M 768  ASP M 771 -1  O  TRP M 770   N  LEU M 758           
SHEET    4 AN4 4 ASN M 776  LYS M 779 -1  O  LYS M 779   N  LEU M 769           
SHEET    1 AN5 4 CYS M 804  TRP M 806  0                                        
SHEET    2 AN5 4 ILE M 813  ALA M 817 -1  O  MET M 814   N  SER M 805           
SHEET    3 AN5 4 LYS M 820  ASP M 825 -1  O  PHE M 822   N  VAL M 815           
SHEET    4 AN5 4 GLY M 830  GLY M 833 -1  O  GLY M 830   N  ASP M 825           
SHEET    1 AN6 3 LEU M 854  ALA M 858  0                                        
SHEET    2 AN6 3 VAL M 864  ASN M 868 -1  O  TRP M 867   N  ALA M 855           
SHEET    3 AN6 3 SER M 873  ALA M 876 -1  O  VAL M 875   N  LEU M 866           
SHEET    1 AN7 3 VAL M 928  PHE M 930  0                                        
SHEET    2 AN7 3 VAL M 935  VAL M 937 -1  O  MET M 936   N  VAL M 929           
SHEET    3 AN7 3 ILE M 949  ASN M 950 -1  O  ILE M 949   N  VAL M 937           
SHEET    1 AN8 2 LEU M 946  GLN M 947  0                                        
SHEET    2 AN8 2 TYR M 958  LEU M 959 -1  O  LEU M 959   N  LEU M 946           
SHEET    1 AN9 2 CYS M 967  LEU M 969  0                                        
SHEET    2 AN9 2 ILE M 976  PHE M 978 -1  O  ALA M 977   N  CYS M 968           
SHEET    1 AO1 2 ILE M 985  GLU M 986  0                                        
SHEET    2 AO1 2 SER M 998  ARG M 999 -1  O  ARG M 999   N  ILE M 985           
SHEET    1 AO2 4 ILE M1009  PHE M1011  0                                        
SHEET    2 AO2 4 LEU M1018  SER M1020 -1  O  ILE M1019   N  GLN M1010           
SHEET    3 AO2 4 ILE M1027  ASN M1031 -1  O  GLN M1028   N  SER M1020           
SHEET    4 AO2 4 LYS M1036  LEU M1040 -1  O  LEU M1040   N  ILE M1027           
SHEET    1 AO3 4 ASP M1049  LEU M1052  0                                        
SHEET    2 AO3 4 ARG M1057  TRP M1061 -1  O  TRP M1061   N  ASP M1049           
SHEET    3 AO3 4 VAL M1067  ASN M1071 -1  O  TRP M1070   N  LEU M1058           
SHEET    4 AO3 4 LYS M1079  PHE M1081 -1  O  PHE M1081   N  VAL M1067           
SHEET    1 AO4 4 SER M1090  ILE M1093  0                                        
SHEET    2 AO4 4 SER M1101  SER M1104 -1  O  SER M1102   N  ASP M1092           
SHEET    3 AO4 4 ALA M1109  TRP M1112 -1  O  TRP M1112   N  SER M1101           
SHEET    4 AO4 4 HIS M1121  LEU M1123 -1  O  HIS M1121   N  ILE M1111           
SHEET    1 AO5 2 CYS M1132  PHE M1135  0                                        
SHEET    2 AO5 2 LEU M1142  GLY M1145 -1  O  GLY M1145   N  CYS M1132           
SHEET    1 AO6 3 ASP M1182  PHE M1185  0                                        
SHEET    2 AO6 3 MET M1191  ALA M1195 -1  O  ILE M1193   N  CYS M1184           
SHEET    3 AO6 3 ILE M1199  ASN M1203 -1  O  TRP M1202   N  LEU M1192           
SHEET    1 AO7 2 VAL M1233  VAL M1235  0                                        
SHEET    2 AO7 2 LEU M1241  ILE M1243 -1  O  TYR M1242   N  THR M1234           
SSBOND   1 CYS A  633    CYS A  663                          1555   1555  2.20  
SSBOND   2 CYS A  675    CYS A  705                          1555   1555  2.02  
SSBOND   3 CYS A  704    CYS A  749                          1555   1555  1.90  
SSBOND   4 CYS A  761    CYS A  804                          1555   1555  2.05  
SSBOND   5 CYS A  803    CYS A  846                          1555   1555  2.09  
SSBOND   6 CYS C  633    CYS C  663                          1555   1555  2.20  
SSBOND   7 CYS C  675    CYS C  705                          1555   1555  2.02  
SSBOND   8 CYS C  704    CYS C  749                          1555   1555  1.90  
SSBOND   9 CYS C  761    CYS C  804                          1555   1555  2.05  
SSBOND  10 CYS C  803    CYS C  846                          1555   1555  2.10  
SSBOND  11 CYS E  633    CYS E  663                          1555   1555  2.20  
SSBOND  12 CYS E  675    CYS E  705                          1555   1555  2.02  
SSBOND  13 CYS E  704    CYS E  749                          1555   1555  1.89  
SSBOND  14 CYS E  761    CYS E  804                          1555   1555  2.05  
SSBOND  15 CYS E  803    CYS E  846                          1555   1555  2.09  
SSBOND  16 CYS G  633    CYS G  663                          1555   1555  2.20  
SSBOND  17 CYS G  675    CYS G  705                          1555   1555  2.02  
SSBOND  18 CYS G  704    CYS G  749                          1555   1555  1.89  
SSBOND  19 CYS G  761    CYS G  804                          1555   1555  2.05  
SSBOND  20 CYS G  803    CYS G  846                          1555   1555  2.09  
SSBOND  21 CYS I  633    CYS I  663                          1555   1555  2.20  
SSBOND  22 CYS I  675    CYS I  705                          1555   1555  2.02  
SSBOND  23 CYS I  704    CYS I  749                          1555   1555  1.89  
SSBOND  24 CYS I  761    CYS I  804                          1555   1555  2.05  
SSBOND  25 CYS I  803    CYS I  846                          1555   1555  2.09  
SSBOND  26 CYS K  633    CYS K  663                          1555   1555  2.19  
SSBOND  27 CYS K  675    CYS K  705                          1555   1555  2.02  
SSBOND  28 CYS K  704    CYS K  749                          1555   1555  1.89  
SSBOND  29 CYS K  761    CYS K  804                          1555   1555  2.05  
SSBOND  30 CYS K  803    CYS K  846                          1555   1555  2.09  
SSBOND  31 CYS M  633    CYS M  663                          1555   1555  2.20  
SSBOND  32 CYS M  675    CYS M  705                          1555   1555  2.02  
SSBOND  33 CYS M  704    CYS M  749                          1555   1555  1.89  
SSBOND  34 CYS M  761    CYS M  804                          1555   1555  2.05  
SSBOND  35 CYS M  803    CYS M  846                          1555   1555  2.10  
LINK         OG  SER A 141                 CD1 LEU W  10     1555   1555  1.49  
LINK         OG  SER A 161                MG    MG A1302     1555   1555  2.43  
LINK         NE2 HIS B  18                FE   HEM B 201     1555   1555  2.37  
LINK         SD  MET B  80                FE   HEM B 201     1555   1555  2.44  
LINK         OG  SER C 161                MG    MG C1302     1555   1555  2.43  
LINK         NE2 HIS D  18                FE   HEM D 201     1555   1555  2.37  
LINK         SD  MET D  80                FE   HEM D 201     1555   1555  2.44  
LINK         OG  SER E 161                MG    MG E1302     1555   1555  2.43  
LINK         NE2 HIS F  18                FE   HEM F 201     1555   1555  2.37  
LINK         SD  MET F  80                FE   HEM F 201     1555   1555  2.44  
LINK         OG  SER G 161                MG    MG G1302     1555   1555  2.43  
LINK         NE2 HIS H  18                FE   HEM H 201     1555   1555  2.37  
LINK         SD  MET H  80                FE   HEM H 201     1555   1555  2.44  
LINK         OG  SER I 161                MG    MG I1302     1555   1555  2.43  
LINK         NE2 HIS J  18                FE   HEM J 201     1555   1555  2.37  
LINK         SD  MET J  80                FE   HEM J 201     1555   1555  2.44  
LINK         OG  SER K 161                MG    MG K1302     1555   1555  2.44  
LINK         NE2 HIS L  18                FE   HEM L 201     1555   1555  2.37  
LINK         SD  MET L  80                FE   HEM L 201     1555   1555  2.44  
LINK         OG  SER M 161                MG    MG M1302     1555   1555  2.43  
LINK         NE2 HIS N  18                FE   HEM N 201     1555   1555  2.37  
LINK         SD  MET N  80                FE   HEM N 201     1555   1555  2.44  
LINK         O3G DTP A1301                MG    MG A1302     1555   1555  2.44  
LINK         O2B DTP A1301                MG    MG A1302     1555   1555  2.17  
LINK         O3G DTP C1301                MG    MG C1302     1555   1555  2.44  
LINK         O2B DTP C1301                MG    MG C1302     1555   1555  2.17  
LINK         O3G DTP E1301                MG    MG E1302     1555   1555  2.44  
LINK         O2B DTP E1301                MG    MG E1302     1555   1555  2.17  
LINK         O3G DTP G1301                MG    MG G1302     1555   1555  2.43  
LINK         O2B DTP G1301                MG    MG G1302     1555   1555  2.17  
LINK         O3G DTP I1301                MG    MG I1302     1555   1555  2.43  
LINK         O2B DTP I1301                MG    MG I1302     1555   1555  2.17  
LINK         O3G DTP K1301                MG    MG K1302     1555   1555  2.43  
LINK         O2B DTP K1301                MG    MG K1302     1555   1555  2.17  
LINK         O3G DTP M1301                MG    MG M1302     1555   1555  2.43  
LINK         O2B DTP M1301                MG    MG M1302     1555   1555  2.17  
SITE     1 AC1 13 VAL A 125  PHE A 126  VAL A 127  GLY A 159                    
SITE     2 AC1 13 LYS A 160  SER A 161  VAL A 162  ASP A 244                    
SITE     3 AC1 13 ARG A 265  PRO A 321  SER A 325  TYR A 359                    
SITE     4 AC1 13  MG A1302                                                     
SITE     1 AC2  3 SER A 161  ASP A 243  DTP A1301                               
SITE     1 AC3 22 LYS B  13  CYS B  14  CYS B  17  HIS B  18                    
SITE     2 AC3 22 THR B  28  GLY B  29  PRO B  30  LEU B  32                    
SITE     3 AC3 22 ARG B  38  THR B  40  GLY B  41  TYR B  48                    
SITE     4 AC3 22 THR B  49  ASN B  52  TRP B  59  TYR B  67                    
SITE     5 AC3 22 THR B  78  LYS B  79  MET B  80  ILE B  81                    
SITE     6 AC3 22 PHE B  82  LEU B  94                                          
SITE     1 AC4 13 VAL C 125  PHE C 126  VAL C 127  GLY C 159                    
SITE     2 AC4 13 LYS C 160  SER C 161  VAL C 162  ASP C 244                    
SITE     3 AC4 13 ARG C 265  PRO C 321  SER C 325  TYR C 359                    
SITE     4 AC4 13  MG C1302                                                     
SITE     1 AC5  3 SER C 161  ASP C 243  DTP C1301                               
SITE     1 AC6 22 LYS D  13  CYS D  14  CYS D  17  HIS D  18                    
SITE     2 AC6 22 THR D  28  GLY D  29  PRO D  30  LEU D  32                    
SITE     3 AC6 22 ARG D  38  THR D  40  GLY D  41  TYR D  48                    
SITE     4 AC6 22 THR D  49  ASN D  52  TRP D  59  TYR D  67                    
SITE     5 AC6 22 THR D  78  LYS D  79  MET D  80  ILE D  81                    
SITE     6 AC6 22 PHE D  82  LEU D  94                                          
SITE     1 AC7 13 VAL E 125  PHE E 126  VAL E 127  GLY E 159                    
SITE     2 AC7 13 LYS E 160  SER E 161  VAL E 162  ASP E 244                    
SITE     3 AC7 13 ARG E 265  PRO E 321  SER E 325  TYR E 359                    
SITE     4 AC7 13  MG E1302                                                     
SITE     1 AC8  3 SER E 161  ASP E 243  DTP E1301                               
SITE     1 AC9 22 LYS F  13  CYS F  14  CYS F  17  HIS F  18                    
SITE     2 AC9 22 THR F  28  GLY F  29  PRO F  30  LEU F  32                    
SITE     3 AC9 22 ARG F  38  THR F  40  GLY F  41  TYR F  48                    
SITE     4 AC9 22 THR F  49  ASN F  52  TRP F  59  TYR F  67                    
SITE     5 AC9 22 THR F  78  LYS F  79  MET F  80  ILE F  81                    
SITE     6 AC9 22 PHE F  82  LEU F  94                                          
SITE     1 AD1 13 VAL G 125  PHE G 126  VAL G 127  GLY G 159                    
SITE     2 AD1 13 LYS G 160  SER G 161  VAL G 162  ASP G 244                    
SITE     3 AD1 13 ARG G 265  PRO G 321  SER G 325  TYR G 359                    
SITE     4 AD1 13  MG G1302                                                     
SITE     1 AD2  3 SER G 161  ASP G 243  DTP G1301                               
SITE     1 AD3 22 LYS H  13  CYS H  14  CYS H  17  HIS H  18                    
SITE     2 AD3 22 THR H  28  GLY H  29  PRO H  30  LEU H  32                    
SITE     3 AD3 22 ARG H  38  THR H  40  GLY H  41  TYR H  48                    
SITE     4 AD3 22 THR H  49  ASN H  52  TRP H  59  TYR H  67                    
SITE     5 AD3 22 THR H  78  LYS H  79  MET H  80  ILE H  81                    
SITE     6 AD3 22 PHE H  82  LEU H  94                                          
SITE     1 AD4 13 VAL I 125  PHE I 126  VAL I 127  GLY I 159                    
SITE     2 AD4 13 LYS I 160  SER I 161  VAL I 162  ASP I 244                    
SITE     3 AD4 13 ARG I 265  PRO I 321  SER I 325  TYR I 359                    
SITE     4 AD4 13  MG I1302                                                     
SITE     1 AD5  3 SER I 161  ASP I 243  DTP I1301                               
SITE     1 AD6 22 LYS J  13  CYS J  14  CYS J  17  HIS J  18                    
SITE     2 AD6 22 THR J  28  GLY J  29  PRO J  30  LEU J  32                    
SITE     3 AD6 22 ARG J  38  THR J  40  GLY J  41  TYR J  48                    
SITE     4 AD6 22 THR J  49  ASN J  52  TRP J  59  TYR J  67                    
SITE     5 AD6 22 THR J  78  LYS J  79  MET J  80  ILE J  81                    
SITE     6 AD6 22 PHE J  82  LEU J  94                                          
SITE     1 AD7 13 VAL K 125  PHE K 126  VAL K 127  GLY K 159                    
SITE     2 AD7 13 LYS K 160  SER K 161  VAL K 162  ASP K 244                    
SITE     3 AD7 13 ARG K 265  PRO K 321  SER K 325  TYR K 359                    
SITE     4 AD7 13  MG K1302                                                     
SITE     1 AD8  3 SER K 161  ASP K 243  DTP K1301                               
SITE     1 AD9 22 LYS L  13  CYS L  14  CYS L  17  HIS L  18                    
SITE     2 AD9 22 THR L  28  GLY L  29  PRO L  30  LEU L  32                    
SITE     3 AD9 22 ARG L  38  THR L  40  GLY L  41  TYR L  48                    
SITE     4 AD9 22 THR L  49  ASN L  52  TRP L  59  TYR L  67                    
SITE     5 AD9 22 THR L  78  LYS L  79  MET L  80  ILE L  81                    
SITE     6 AD9 22 PHE L  82  LEU L  94                                          
SITE     1 AE1 13 VAL M 125  PHE M 126  VAL M 127  GLY M 159                    
SITE     2 AE1 13 LYS M 160  SER M 161  VAL M 162  ASP M 244                    
SITE     3 AE1 13 ARG M 265  PRO M 321  SER M 325  TYR M 359                    
SITE     4 AE1 13  MG M1302                                                     
SITE     1 AE2  3 SER M 161  ASP M 243  DTP M1301                               
SITE     1 AE3 22 LYS N  13  CYS N  14  CYS N  17  HIS N  18                    
SITE     2 AE3 22 THR N  28  GLY N  29  PRO N  30  LEU N  32                    
SITE     3 AE3 22 ARG N  38  THR N  40  GLY N  41  TYR N  48                    
SITE     4 AE3 22 THR N  49  ASN N  52  TRP N  59  TYR N  67                    
SITE     5 AE3 22 THR N  78  LYS N  79  MET N  80  ILE N  81                    
SITE     6 AE3 22 PHE N  82  LEU N  94                                          
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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