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Database: PDB
Entry: 5XEU
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Original site: 5XEU 
HEADER    CYTOSOLIC PROTEIN                       06-APR-17   5XEU              
TITLE     CRYSTAL STRUCTURE OF HCP2 FROM SALMONELLA TYPHIMURIUM                 
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: HCP1 FAMILY TYPE VI SECRETION SYSTEM EFFECTOR;             
COMPND   3 CHAIN: A, B, C, D, E, F;                                             
COMPND   4 SYNONYM: PUTATIVE CYTOPLASMIC PROTEIN USSDB7A,SCIM PROTEIN;          
COMPND   5 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SALMONELLA TYPHIMURIUM;                         
SOURCE   3 ORGANISM_TAXID: 90371;                                               
SOURCE   4 GENE: SCIM, BKC11_01435, BLM41_12410, DD95_17705, SEETMRM10961_1365; 
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PET28A                                    
KEYWDS    HEXAMERIC, CYTOSOLIC PROTEIN                                          
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    Q.P.LIN,Z.Q.GAO,H.ZHANG                                               
REVDAT   1   16-AUG-17 5XEU    0                                                
JRNL        AUTH   Q.P.LIN,Z.Q.GAO,Z.GENG,H.ZHANG,Y.H.DONG                      
JRNL        TITL   CRYSTAL STRUCTURE OF THE PUTATIVE CYTOPLASMIC PROTEIN        
JRNL        TITL 2 STM0279 (HCP2) FROM SALMONELLA TYPHIMURIUM                   
JRNL        REF    ACTA CRYSTALLOGR F STRUCT     V.  73   463 2017              
JRNL        REF  2 BIOL COMMUN                                                  
JRNL        REFN                   ESSN 2053-230X                               
JRNL        PMID   28777089                                                     
JRNL        DOI    10.1107/S2053230X17010512                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (1.10.1_2155: ???)                            
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.00                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 32.80                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.6                           
REMARK   3   NUMBER OF REFLECTIONS             : 20970                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.239                           
REMARK   3   R VALUE            (WORKING SET) : 0.238                           
REMARK   3   FREE R VALUE                     : 0.280                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.030                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 1055                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 27.7766 -  5.7268    0.93     2849   157  0.2254 0.2623        
REMARK   3     2  5.7268 -  4.5520    0.95     2908   122  0.1878 0.2660        
REMARK   3     3  4.5520 -  3.9785    0.93     2834   166  0.2164 0.2467        
REMARK   3     4  3.9785 -  3.6156    0.93     2786   151  0.2711 0.3124        
REMARK   3     5  3.6156 -  3.3569    0.93     2828   151  0.2870 0.3437        
REMARK   3     6  3.3569 -  3.1593    0.95     2851   142  0.2990 0.3075        
REMARK   3     7  3.1593 -  3.0012    0.95     2860   131  0.3053 0.3185        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : NULL                                          
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : NULL             
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 47.940           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.009           6047                                  
REMARK   3   ANGLE     :  1.091           8164                                  
REMARK   3   CHIRALITY :  0.060            911                                  
REMARK   3   PLANARITY :  0.006           1031                                  
REMARK   3   DIHEDRAL  : 18.896           3545                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 5XEU COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 10-APR-17.                  
REMARK 100 THE DEPOSITION ID IS D_1300003399.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 24-MAR-17                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 5.6                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : SSRF                               
REMARK 200  BEAMLINE                       : BL19U1                             
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9792                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS3 S 6M              
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-3000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-3000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 21754                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.000                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.1                               
REMARK 200  DATA REDUNDANCY                : 2.700                              
REMARK 200  R MERGE                    (I) : 0.07200                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 16.2000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.00                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.05                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.5                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.70                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.53000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 1Y12                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 51.52                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.54                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 2.2M AMMONIUM SULFATE, 0.1M AMMONIUM     
REMARK 280  ACETATE, PH 5.6, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y,-Z                                                 
REMARK 290       3555   X+1/2,Y+1/2,Z                                           
REMARK 290       4555   -X+1/2,Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       51.32250            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       73.89300            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       51.32250            
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       73.89300            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 11470 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 33640 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -85.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     GLN A    36                                                      
REMARK 465     GLU A    37                                                      
REMARK 465     SER A    38                                                      
REMARK 465     THR A    39                                                      
REMARK 465     MET A    40                                                      
REMARK 465     HIS A    41                                                      
REMARK 465     ALA A    42                                                      
REMARK 465     GLY A    43                                                      
REMARK 465     SER A    44                                                      
REMARK 465     GLY A    45                                                      
REMARK 465     LEU A    46                                                      
REMARK 465     GLY A    47                                                      
REMARK 465     SER A    48                                                      
REMARK 465     GLY A    49                                                      
REMARK 465     LYS A    50                                                      
REMARK 465     GLY A    90                                                      
REMARK 465     GLY A    91                                                      
REMARK 465     ASN A    92                                                      
REMARK 465     PRO A    93                                                      
REMARK 465     GLY A   116                                                      
REMARK 465     GLY A   117                                                      
REMARK 465     GLU A   118                                                      
REMARK 465     ILE A   119                                                      
REMARK 465     ASN A   140                                                      
REMARK 465     GLN A   141                                                      
REMARK 465     GLN A   142                                                      
REMARK 465     GLY A   143                                                      
REMARK 465     GLY A   144                                                      
REMARK 465     SER A   145                                                      
REMARK 465     GLY A   146                                                      
REMARK 465     ILE A   161                                                      
REMARK 465     MET B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     GLN B    36                                                      
REMARK 465     GLU B    37                                                      
REMARK 465     SER B    38                                                      
REMARK 465     THR B    39                                                      
REMARK 465     MET B    40                                                      
REMARK 465     HIS B    41                                                      
REMARK 465     ALA B    42                                                      
REMARK 465     GLY B    43                                                      
REMARK 465     SER B    44                                                      
REMARK 465     GLY B    45                                                      
REMARK 465     LEU B    46                                                      
REMARK 465     GLY B    47                                                      
REMARK 465     SER B    48                                                      
REMARK 465     GLY B    49                                                      
REMARK 465     LYS B    50                                                      
REMARK 465     GLY B    90                                                      
REMARK 465     GLY B    91                                                      
REMARK 465     ASN B    92                                                      
REMARK 465     PRO B    93                                                      
REMARK 465     LEU B    94                                                      
REMARK 465     GLY B   116                                                      
REMARK 465     GLY B   117                                                      
REMARK 465     GLU B   118                                                      
REMARK 465     ILE B   119                                                      
REMARK 465     ASN B   140                                                      
REMARK 465     GLN B   141                                                      
REMARK 465     GLN B   142                                                      
REMARK 465     GLY B   143                                                      
REMARK 465     GLY B   144                                                      
REMARK 465     SER B   145                                                      
REMARK 465     ILE B   161                                                      
REMARK 465     MET C     1                                                      
REMARK 465     SER C     2                                                      
REMARK 465     GLN C    36                                                      
REMARK 465     GLU C    37                                                      
REMARK 465     SER C    38                                                      
REMARK 465     THR C    39                                                      
REMARK 465     MET C    40                                                      
REMARK 465     HIS C    41                                                      
REMARK 465     ALA C    42                                                      
REMARK 465     GLY C    43                                                      
REMARK 465     SER C    44                                                      
REMARK 465     GLY C    45                                                      
REMARK 465     LEU C    46                                                      
REMARK 465     GLY C    47                                                      
REMARK 465     SER C    48                                                      
REMARK 465     GLY C    49                                                      
REMARK 465     LYS C    50                                                      
REMARK 465     GLY C    90                                                      
REMARK 465     GLY C    91                                                      
REMARK 465     ASN C    92                                                      
REMARK 465     PRO C    93                                                      
REMARK 465     GLY C   116                                                      
REMARK 465     GLY C   117                                                      
REMARK 465     GLU C   118                                                      
REMARK 465     ILE C   119                                                      
REMARK 465     ASN C   140                                                      
REMARK 465     GLN C   141                                                      
REMARK 465     GLN C   142                                                      
REMARK 465     GLY C   143                                                      
REMARK 465     GLY C   144                                                      
REMARK 465     SER C   145                                                      
REMARK 465     ILE C   161                                                      
REMARK 465     MET D     1                                                      
REMARK 465     SER D     2                                                      
REMARK 465     GLN D    36                                                      
REMARK 465     GLU D    37                                                      
REMARK 465     SER D    38                                                      
REMARK 465     THR D    39                                                      
REMARK 465     MET D    40                                                      
REMARK 465     HIS D    41                                                      
REMARK 465     ALA D    42                                                      
REMARK 465     GLY D    43                                                      
REMARK 465     SER D    44                                                      
REMARK 465     GLY D    45                                                      
REMARK 465     LEU D    46                                                      
REMARK 465     GLY D    47                                                      
REMARK 465     SER D    48                                                      
REMARK 465     GLY D    49                                                      
REMARK 465     LYS D    50                                                      
REMARK 465     GLY D    90                                                      
REMARK 465     GLY D    91                                                      
REMARK 465     ASN D    92                                                      
REMARK 465     PRO D    93                                                      
REMARK 465     LEU D    94                                                      
REMARK 465     GLY D   116                                                      
REMARK 465     GLY D   117                                                      
REMARK 465     GLU D   118                                                      
REMARK 465     ILE D   119                                                      
REMARK 465     GLN D   141                                                      
REMARK 465     GLN D   142                                                      
REMARK 465     GLY D   143                                                      
REMARK 465     GLY D   144                                                      
REMARK 465     SER D   145                                                      
REMARK 465     ILE D   161                                                      
REMARK 465     MET E     1                                                      
REMARK 465     SER E     2                                                      
REMARK 465     GLN E    36                                                      
REMARK 465     GLU E    37                                                      
REMARK 465     SER E    38                                                      
REMARK 465     THR E    39                                                      
REMARK 465     MET E    40                                                      
REMARK 465     HIS E    41                                                      
REMARK 465     ALA E    42                                                      
REMARK 465     GLY E    43                                                      
REMARK 465     SER E    44                                                      
REMARK 465     GLY E    45                                                      
REMARK 465     LEU E    46                                                      
REMARK 465     GLY E    47                                                      
REMARK 465     SER E    48                                                      
REMARK 465     GLY E    49                                                      
REMARK 465     LYS E    50                                                      
REMARK 465     GLY E    90                                                      
REMARK 465     GLY E    91                                                      
REMARK 465     ASN E    92                                                      
REMARK 465     PRO E    93                                                      
REMARK 465     GLY E   116                                                      
REMARK 465     GLY E   117                                                      
REMARK 465     GLU E   118                                                      
REMARK 465     ILE E   119                                                      
REMARK 465     GLN E   139                                                      
REMARK 465     ASN E   140                                                      
REMARK 465     GLN E   141                                                      
REMARK 465     GLN E   142                                                      
REMARK 465     GLY E   143                                                      
REMARK 465     GLY E   144                                                      
REMARK 465     SER E   145                                                      
REMARK 465     ILE E   161                                                      
REMARK 465     MET F     1                                                      
REMARK 465     SER F     2                                                      
REMARK 465     GLN F    36                                                      
REMARK 465     GLU F    37                                                      
REMARK 465     SER F    38                                                      
REMARK 465     THR F    39                                                      
REMARK 465     MET F    40                                                      
REMARK 465     HIS F    41                                                      
REMARK 465     ALA F    42                                                      
REMARK 465     GLY F    43                                                      
REMARK 465     SER F    44                                                      
REMARK 465     GLY F    45                                                      
REMARK 465     LEU F    46                                                      
REMARK 465     GLY F    47                                                      
REMARK 465     SER F    48                                                      
REMARK 465     GLY F    49                                                      
REMARK 465     LYS F    50                                                      
REMARK 465     GLY F    90                                                      
REMARK 465     GLY F    91                                                      
REMARK 465     ASN F    92                                                      
REMARK 465     PRO F    93                                                      
REMARK 465     GLY F   116                                                      
REMARK 465     GLY F   117                                                      
REMARK 465     GLU F   118                                                      
REMARK 465     ILE F   119                                                      
REMARK 465     GLN F   139                                                      
REMARK 465     ASN F   140                                                      
REMARK 465     GLN F   141                                                      
REMARK 465     GLN F   142                                                      
REMARK 465     GLY F   143                                                      
REMARK 465     GLY F   144                                                      
REMARK 465     SER F   145                                                      
REMARK 465     ILE F   161                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     MET A  17    SD   CE                                             
REMARK 470     LYS A  20    CD   CE   NZ                                        
REMARK 470     LYS A  22    CG   CD   CE   NZ                                   
REMARK 470     ASN A  23    OD1  ND2                                            
REMARK 470     ASN A  33    OD1  ND2                                            
REMARK 470     HIS A  35    ND1  CD2  CE1  NE2                                  
REMARK 470     VAL A  51    CG1  CG2                                            
REMARK 470     THR A  54    CG2                                                 
REMARK 470     LYS A  71    CG   CD   CE   NZ                                   
REMARK 470     LYS A  77    CG   CD   CE   NZ                                   
REMARK 470     THR A 102    CG2                                                 
REMARK 470     MET A 108    SD   CE                                             
REMARK 470     ARG A 122    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER A 130    OG                                                  
REMARK 470     ILE A 149    CG2  CD1                                            
REMARK 470     LYS A 159    CG   CD   CE   NZ                                   
REMARK 470     TYR B   3    N                                                   
REMARK 470     LYS B  20    CD   CE   NZ                                        
REMARK 470     LYS B  22    CG   CD   CE   NZ                                   
REMARK 470     ASN B  23    OD1  ND2                                            
REMARK 470     HIS B  35    ND1  CD2  CE1  NE2                                  
REMARK 470     VAL B  51    CG1  CG2                                            
REMARK 470     LYS B  71    CG   CD   CE   NZ                                   
REMARK 470     LYS B  77    CG   CD   CE   NZ                                   
REMARK 470     MET B 108    SD   CE                                             
REMARK 470     ARG B 122    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER B 130    OG                                                  
REMARK 470     ILE B 149    CG2  CD1                                            
REMARK 470     LYS B 159    CG   CD   CE   NZ                                   
REMARK 470     MET C  17    SD   CE                                             
REMARK 470     LYS C  20    CD   CE   NZ                                        
REMARK 470     LYS C  22    CG   CD   CE   NZ                                   
REMARK 470     ASN C  23    OD1  ND2                                            
REMARK 470     GLU C  24    CG   CD   OE1  OE2                                  
REMARK 470     HIS C  35    ND1  CD2  CE1  NE2                                  
REMARK 470     VAL C  51    CG1  CG2                                            
REMARK 470     THR C  54    CG2                                                 
REMARK 470     LYS C  71    CG   CD   CE   NZ                                   
REMARK 470     LYS C  77    CG   CD   CE   NZ                                   
REMARK 470     THR C 102    CG2                                                 
REMARK 470     MET C 108    SD   CE                                             
REMARK 470     ARG C 122    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER C 130    OG                                                  
REMARK 470     THR C 131    CG2                                                 
REMARK 470     ILE C 149    CG2  CD1                                            
REMARK 470     LYS C 159    CG   CD   CE   NZ                                   
REMARK 470     MET D  17    SD   CE                                             
REMARK 470     LYS D  20    CD   CE   NZ                                        
REMARK 470     LYS D  22    CG   CD   CE   NZ                                   
REMARK 470     ASN D  23    OD1  ND2                                            
REMARK 470     ASN D  33    OD1  ND2                                            
REMARK 470     HIS D  35    ND1  CD2  CE1  NE2                                  
REMARK 470     VAL D  51    CG1  CG2                                            
REMARK 470     THR D  54    CG2                                                 
REMARK 470     LYS D  71    CG   CD   CE   NZ                                   
REMARK 470     LYS D  77    CG   CD   CE   NZ                                   
REMARK 470     THR D 102    CG2                                                 
REMARK 470     MET D 108    SD   CE                                             
REMARK 470     ARG D 122    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER D 130    OG                                                  
REMARK 470     THR D 131    CG2                                                 
REMARK 470     ILE D 149    CG2  CD1                                            
REMARK 470     LYS D 159    CG   CD   CE   NZ                                   
REMARK 470     MET E  17    SD   CE                                             
REMARK 470     LYS E  20    CD   CE   NZ                                        
REMARK 470     LYS E  22    CG   CD   CE   NZ                                   
REMARK 470     ASN E  23    OD1  ND2                                            
REMARK 470     ASN E  33    OD1  ND2                                            
REMARK 470     HIS E  35    ND1  CD2  CE1  NE2                                  
REMARK 470     VAL E  51    CG1  CG2                                            
REMARK 470     THR E  54    CG2                                                 
REMARK 470     LYS E  71    CG   CD   CE   NZ                                   
REMARK 470     LYS E  77    CG   CD   CE   NZ                                   
REMARK 470     MET E 108    SD   CE                                             
REMARK 470     SER E 130    OG                                                  
REMARK 470     THR E 131    CG2                                                 
REMARK 470     ILE E 149    CG2  CD1                                            
REMARK 470     LYS E 159    CG   CD   CE   NZ                                   
REMARK 470     MET F  17    SD   CE                                             
REMARK 470     LYS F  20    CD   CE   NZ                                        
REMARK 470     LYS F  22    CG   CD   CE   NZ                                   
REMARK 470     ASN F  23    OD1  ND2                                            
REMARK 470     ASN F  33    OD1  ND2                                            
REMARK 470     HIS F  35    ND1  CD2  CE1  NE2                                  
REMARK 470     VAL F  51    CG1  CG2                                            
REMARK 470     THR F  54    CG2                                                 
REMARK 470     LYS F  71    CG   CD   CE   NZ                                   
REMARK 470     LYS F  77    CG   CD   CE   NZ                                   
REMARK 470     THR F 102    CG2                                                 
REMARK 470     MET F 108    SD   CE                                             
REMARK 470     ARG F 122    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER F 130    OG                                                  
REMARK 470     THR F 131    CG2                                                 
REMARK 470     ILE F 149    CG2  CD1                                            
REMARK 470     LYS F 159    CG   CD   CE   NZ                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    ASP E   154     O    ALA E   157              1.94            
REMARK 500   CE1  PHE A   101     CG2  VAL A   132              1.98            
REMARK 500   OG   SER A    66     OE2  GLU A   123              2.15            
REMARK 500   OD2  ASP B   103     NZ   LYS B   156              2.17            
REMARK 500   OG1  THR C   102     OG1  THR C   131              2.17            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ALA E 157   CB  -  CA  -  C   ANGL. DEV. =  12.5 DEGREES          
REMARK 500    ALA E 157   N   -  CA  -  C   ANGL. DEV. = -17.2 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    MET A  17       61.00   -152.46                                   
REMARK 500    LYS A  20       -5.56    -59.30                                   
REMARK 500    HIS A  21      106.46   -176.72                                   
REMARK 500    TYR A  96       -4.34   -148.56                                   
REMARK 500    SER A 112      151.94    179.60                                   
REMARK 500    TYR A 153      142.87    177.59                                   
REMARK 500    ALA A 157      104.05   -164.24                                   
REMARK 500    ASN A 158       68.99    -68.51                                   
REMARK 500    ASP B  10      104.90    -53.12                                   
REMARK 500    HIS B  21       66.94   -155.58                                   
REMARK 500    TRP B  30      149.62   -173.28                                   
REMARK 500    ASP B 103       42.76     86.41                                   
REMARK 500    GLU B 123      109.07   -160.24                                   
REMARK 500    LYS B 159      -99.44   -118.82                                   
REMARK 500    ASP C  18      174.78    -58.51                                   
REMARK 500    ASN C  23       55.74     36.86                                   
REMARK 500    TYR C  61     -179.44    -68.14                                   
REMARK 500    LYS C  88     -160.60    -72.23                                   
REMARK 500    TYR C  96      -21.00   -160.72                                   
REMARK 500    ASP C 103      109.39     72.74                                   
REMARK 500    ALA C 107      -63.40   -101.89                                   
REMARK 500    SER C 114      138.24   -172.97                                   
REMARK 500    GLU C 123      101.09   -165.00                                   
REMARK 500    LEU C 127      147.00   -178.60                                   
REMARK 500    ASN C 158      115.62    -34.18                                   
REMARK 500    TRP D  32      156.52    177.74                                   
REMARK 500    ASP D 103       77.34     44.89                                   
REMARK 500    ALA D 107      -75.26    -59.16                                   
REMARK 500    SER D 110       89.78   -153.49                                   
REMARK 500    SER D 112      175.69    170.10                                   
REMARK 500    SER D 114     -167.23   -170.45                                   
REMARK 500    TYR D 153      141.58    177.28                                   
REMARK 500    ASN D 158       66.39    -42.68                                   
REMARK 500    HIS E  21      105.73    175.35                                   
REMARK 500    ILE E  62      105.09    -59.69                                   
REMARK 500    LEU E 127      118.42   -160.67                                   
REMARK 500    SER E 130      -62.71   -123.84                                   
REMARK 500    TYR E 136      109.70   -174.03                                   
REMARK 500    GLU F  15       10.22   -160.50                                   
REMARK 500    HIS F  21      103.07   -164.46                                   
REMARK 500    ASN F  23       65.27     38.80                                   
REMARK 500    SER F  29      140.73   -177.88                                   
REMARK 500    ARG F  31      146.37   -178.06                                   
REMARK 500    VAL F  53      151.96    -47.87                                   
REMARK 500    ASN F  55     -166.61    -69.08                                   
REMARK 500    ASP F 103       83.47     66.49                                   
REMARK 500    GLU F 123      100.04   -161.59                                   
REMARK 500    TYR F 153      146.72   -172.85                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  5XEU A    1   161  UNP    H9L4J8   H9L4J8_SALTM     1    161             
DBREF  5XEU B    1   161  UNP    H9L4J8   H9L4J8_SALTM     1    161             
DBREF  5XEU C    1   161  UNP    H9L4J8   H9L4J8_SALTM     1    161             
DBREF  5XEU D    1   161  UNP    H9L4J8   H9L4J8_SALTM     1    161             
DBREF  5XEU E    1   161  UNP    H9L4J8   H9L4J8_SALTM     1    161             
DBREF  5XEU F    1   161  UNP    H9L4J8   H9L4J8_SALTM     1    161             
SEQRES   1 A  161  MET SER TYR ASP ILE PHE LEU LYS ILE ASP GLY ILE ASP          
SEQRES   2 A  161  GLY GLU SER MET ASP ASP LYS HIS LYS ASN GLU ILE GLU          
SEQRES   3 A  161  VAL LEU SER TRP ARG TRP ASN ILE HIS GLN GLU SER THR          
SEQRES   4 A  161  MET HIS ALA GLY SER GLY LEU GLY SER GLY LYS VAL SER          
SEQRES   5 A  161  VAL THR ASN LEU SER PHE GLU HIS TYR ILE ASP ARG ALA          
SEQRES   6 A  161  SER PRO ASN LEU PHE LYS TYR CYS SER SER GLY LYS HIS          
SEQRES   7 A  161  ILE PRO GLN ALA ILE LEU VAL MET ARG LYS ALA GLY GLY          
SEQRES   8 A  161  ASN PRO LEU GLU TYR LEU LYS TYR THR PHE THR ASP LEU          
SEQRES   9 A  161  ILE ILE ALA MET VAL SER PRO SER GLY SER GLN GLY GLY          
SEQRES  10 A  161  GLU ILE ALA SER ARG GLU SER ILE GLU LEU SER PHE SER          
SEQRES  11 A  161  THR VAL LYS GLN GLU TYR VAL VAL GLN ASN GLN GLN GLY          
SEQRES  12 A  161  GLY SER GLY GLY THR ILE THR ALA GLY TYR ASP PHE LYS          
SEQRES  13 A  161  ALA ASN LYS GLU ILE                                          
SEQRES   1 B  161  MET SER TYR ASP ILE PHE LEU LYS ILE ASP GLY ILE ASP          
SEQRES   2 B  161  GLY GLU SER MET ASP ASP LYS HIS LYS ASN GLU ILE GLU          
SEQRES   3 B  161  VAL LEU SER TRP ARG TRP ASN ILE HIS GLN GLU SER THR          
SEQRES   4 B  161  MET HIS ALA GLY SER GLY LEU GLY SER GLY LYS VAL SER          
SEQRES   5 B  161  VAL THR ASN LEU SER PHE GLU HIS TYR ILE ASP ARG ALA          
SEQRES   6 B  161  SER PRO ASN LEU PHE LYS TYR CYS SER SER GLY LYS HIS          
SEQRES   7 B  161  ILE PRO GLN ALA ILE LEU VAL MET ARG LYS ALA GLY GLY          
SEQRES   8 B  161  ASN PRO LEU GLU TYR LEU LYS TYR THR PHE THR ASP LEU          
SEQRES   9 B  161  ILE ILE ALA MET VAL SER PRO SER GLY SER GLN GLY GLY          
SEQRES  10 B  161  GLU ILE ALA SER ARG GLU SER ILE GLU LEU SER PHE SER          
SEQRES  11 B  161  THR VAL LYS GLN GLU TYR VAL VAL GLN ASN GLN GLN GLY          
SEQRES  12 B  161  GLY SER GLY GLY THR ILE THR ALA GLY TYR ASP PHE LYS          
SEQRES  13 B  161  ALA ASN LYS GLU ILE                                          
SEQRES   1 C  161  MET SER TYR ASP ILE PHE LEU LYS ILE ASP GLY ILE ASP          
SEQRES   2 C  161  GLY GLU SER MET ASP ASP LYS HIS LYS ASN GLU ILE GLU          
SEQRES   3 C  161  VAL LEU SER TRP ARG TRP ASN ILE HIS GLN GLU SER THR          
SEQRES   4 C  161  MET HIS ALA GLY SER GLY LEU GLY SER GLY LYS VAL SER          
SEQRES   5 C  161  VAL THR ASN LEU SER PHE GLU HIS TYR ILE ASP ARG ALA          
SEQRES   6 C  161  SER PRO ASN LEU PHE LYS TYR CYS SER SER GLY LYS HIS          
SEQRES   7 C  161  ILE PRO GLN ALA ILE LEU VAL MET ARG LYS ALA GLY GLY          
SEQRES   8 C  161  ASN PRO LEU GLU TYR LEU LYS TYR THR PHE THR ASP LEU          
SEQRES   9 C  161  ILE ILE ALA MET VAL SER PRO SER GLY SER GLN GLY GLY          
SEQRES  10 C  161  GLU ILE ALA SER ARG GLU SER ILE GLU LEU SER PHE SER          
SEQRES  11 C  161  THR VAL LYS GLN GLU TYR VAL VAL GLN ASN GLN GLN GLY          
SEQRES  12 C  161  GLY SER GLY GLY THR ILE THR ALA GLY TYR ASP PHE LYS          
SEQRES  13 C  161  ALA ASN LYS GLU ILE                                          
SEQRES   1 D  161  MET SER TYR ASP ILE PHE LEU LYS ILE ASP GLY ILE ASP          
SEQRES   2 D  161  GLY GLU SER MET ASP ASP LYS HIS LYS ASN GLU ILE GLU          
SEQRES   3 D  161  VAL LEU SER TRP ARG TRP ASN ILE HIS GLN GLU SER THR          
SEQRES   4 D  161  MET HIS ALA GLY SER GLY LEU GLY SER GLY LYS VAL SER          
SEQRES   5 D  161  VAL THR ASN LEU SER PHE GLU HIS TYR ILE ASP ARG ALA          
SEQRES   6 D  161  SER PRO ASN LEU PHE LYS TYR CYS SER SER GLY LYS HIS          
SEQRES   7 D  161  ILE PRO GLN ALA ILE LEU VAL MET ARG LYS ALA GLY GLY          
SEQRES   8 D  161  ASN PRO LEU GLU TYR LEU LYS TYR THR PHE THR ASP LEU          
SEQRES   9 D  161  ILE ILE ALA MET VAL SER PRO SER GLY SER GLN GLY GLY          
SEQRES  10 D  161  GLU ILE ALA SER ARG GLU SER ILE GLU LEU SER PHE SER          
SEQRES  11 D  161  THR VAL LYS GLN GLU TYR VAL VAL GLN ASN GLN GLN GLY          
SEQRES  12 D  161  GLY SER GLY GLY THR ILE THR ALA GLY TYR ASP PHE LYS          
SEQRES  13 D  161  ALA ASN LYS GLU ILE                                          
SEQRES   1 E  161  MET SER TYR ASP ILE PHE LEU LYS ILE ASP GLY ILE ASP          
SEQRES   2 E  161  GLY GLU SER MET ASP ASP LYS HIS LYS ASN GLU ILE GLU          
SEQRES   3 E  161  VAL LEU SER TRP ARG TRP ASN ILE HIS GLN GLU SER THR          
SEQRES   4 E  161  MET HIS ALA GLY SER GLY LEU GLY SER GLY LYS VAL SER          
SEQRES   5 E  161  VAL THR ASN LEU SER PHE GLU HIS TYR ILE ASP ARG ALA          
SEQRES   6 E  161  SER PRO ASN LEU PHE LYS TYR CYS SER SER GLY LYS HIS          
SEQRES   7 E  161  ILE PRO GLN ALA ILE LEU VAL MET ARG LYS ALA GLY GLY          
SEQRES   8 E  161  ASN PRO LEU GLU TYR LEU LYS TYR THR PHE THR ASP LEU          
SEQRES   9 E  161  ILE ILE ALA MET VAL SER PRO SER GLY SER GLN GLY GLY          
SEQRES  10 E  161  GLU ILE ALA SER ARG GLU SER ILE GLU LEU SER PHE SER          
SEQRES  11 E  161  THR VAL LYS GLN GLU TYR VAL VAL GLN ASN GLN GLN GLY          
SEQRES  12 E  161  GLY SER GLY GLY THR ILE THR ALA GLY TYR ASP PHE LYS          
SEQRES  13 E  161  ALA ASN LYS GLU ILE                                          
SEQRES   1 F  161  MET SER TYR ASP ILE PHE LEU LYS ILE ASP GLY ILE ASP          
SEQRES   2 F  161  GLY GLU SER MET ASP ASP LYS HIS LYS ASN GLU ILE GLU          
SEQRES   3 F  161  VAL LEU SER TRP ARG TRP ASN ILE HIS GLN GLU SER THR          
SEQRES   4 F  161  MET HIS ALA GLY SER GLY LEU GLY SER GLY LYS VAL SER          
SEQRES   5 F  161  VAL THR ASN LEU SER PHE GLU HIS TYR ILE ASP ARG ALA          
SEQRES   6 F  161  SER PRO ASN LEU PHE LYS TYR CYS SER SER GLY LYS HIS          
SEQRES   7 F  161  ILE PRO GLN ALA ILE LEU VAL MET ARG LYS ALA GLY GLY          
SEQRES   8 F  161  ASN PRO LEU GLU TYR LEU LYS TYR THR PHE THR ASP LEU          
SEQRES   9 F  161  ILE ILE ALA MET VAL SER PRO SER GLY SER GLN GLY GLY          
SEQRES  10 F  161  GLU ILE ALA SER ARG GLU SER ILE GLU LEU SER PHE SER          
SEQRES  11 F  161  THR VAL LYS GLN GLU TYR VAL VAL GLN ASN GLN GLN GLY          
SEQRES  12 F  161  GLY SER GLY GLY THR ILE THR ALA GLY TYR ASP PHE LYS          
SEQRES  13 F  161  ALA ASN LYS GLU ILE                                          
HELIX    1 AA1 ARG A   64  GLY A   76  1                                  13    
HELIX    2 AA2 ARG B   64  GLY B   76  1                                  13    
HELIX    3 AA3 ARG C   64  GLY C   76  1                                  13    
HELIX    4 AA4 ARG D   64  SER D   75  1                                  12    
HELIX    5 AA5 ALA E   65  GLY E   76  1                                  12    
HELIX    6 AA6 ARG F   64  GLY F   76  1                                  13    
SHEET    1 AA113 ALA A 151  ASP A 154  0                                        
SHEET    2 AA113 THR A 131  TYR A 136 -1  N  GLN A 134   O  ALA A 151           
SHEET    3 AA113 LEU A  97  THR A 102 -1  N  LYS A  98   O  GLU A 135           
SHEET    4 AA113 GLN A  81  ARG A  87 -1  N  LEU A  84   O  TYR A  99           
SHEET    5 AA113 ASP A   4  ILE A   9 -1  N  PHE A   6   O  VAL A  85           
SHEET    6 AA113 ILE A  25  ARG A  31 -1  O  ILE A  25   N  LEU A   7           
SHEET    7 AA113 LEU A  56  TYR A  61 -1  O  GLU A  59   N  LEU A  28           
SHEET    8 AA113 SER A 121  SER A 128 -1  O  GLU A 123   N  HIS A  60           
SHEET    9 AA113 ILE A 105  SER A 114 -1  N  ILE A 105   O  SER A 128           
SHEET   10 AA113 SER D  29  ARG D  31 -1  O  TRP D  30   N  GLY A 113           
SHEET   11 AA113 LEU D  56  TYR D  61 -1  O  GLU D  59   N  SER D  29           
SHEET   12 AA113 ARG D 122  VAL D 138 -1  O  LEU D 127   N  LEU D  56           
SHEET   13 AA113 GLY D 147  ASP D 154 -1  O  GLY D 147   N  VAL D 138           
SHEET    1 AA219 GLY B 147  ASP B 154  0                                        
SHEET    2 AA219 THR B 131  VAL B 138 -1  N  GLN B 134   O  ALA B 151           
SHEET    3 AA219 LEU B  97  SER B 114 -1  N  LYS B  98   O  GLU B 135           
SHEET    4 AA219 ARG B 122  SER B 128 -1  O  ARG B 122   N  SER B 112           
SHEET    5 AA219 LEU B  56  TYR B  61 -1  N  LEU B  56   O  LEU B 127           
SHEET    6 AA219 ILE B  25  ARG B  31 -1  N  LEU B  28   O  GLU B  59           
SHEET    7 AA219 ASP B   4  ILE B   9 -1  N  LEU B   7   O  ILE B  25           
SHEET    8 AA219 ILE B  79  ARG B  87 -1  O  VAL B  85   N  PHE B   6           
SHEET    9 AA219 LEU B  97  SER B 114 -1  O  TYR B  99   N  LEU B  84           
SHEET   10 AA219 SER F  29  ARG F  31 -1  O  TRP F  30   N  GLY B 113           
SHEET   11 AA219 LEU F  56  TYR F  61 -1  O  SER F  57   N  ARG F  31           
SHEET   12 AA219 ARG F 122  VAL F 137 -1  O  ILE F 125   N  PHE F  58           
SHEET   13 AA219 GLU F  95  GLY F 113 -1  N  THR F 100   O  LYS F 133           
SHEET   14 AA219 ILE C  25  ARG C  31 -1  N  TRP C  30   O  GLY F 113           
SHEET   15 AA219 ASP C   4  ILE C   9 -1  N  LEU C   7   O  ILE C  25           
SHEET   16 AA219 ILE C  79  ARG C  87 -1  O  ILE C  83   N  LYS C   8           
SHEET   17 AA219 GLU C  95  SER C 114 -1  O  TYR C  99   N  LEU C  84           
SHEET   18 AA219 ARG C 122  TYR C 136 -1  O  GLU C 126   N  MET C 108           
SHEET   19 AA219 ILE C 149  ASP C 154 -1  O  ILE C 149   N  TYR C 136           
SHEET    1 AA3 6 ILE D  25  GLU D  26  0                                        
SHEET    2 AA3 6 ASP D   4  ILE D   9 -1  N  LEU D   7   O  ILE D  25           
SHEET    3 AA3 6 ILE D  79  ARG D  87 -1  O  ILE D  83   N  LYS D   8           
SHEET    4 AA3 6 LEU D  97  SER D 114 -1  O  LEU D 104   N  ILE D  79           
SHEET    5 AA3 6 ARG D 122  VAL D 138 -1  O  GLU D 135   N  LYS D  98           
SHEET    6 AA3 6 GLY D 147  ASP D 154 -1  O  GLY D 147   N  VAL D 138           
SHEET    1 AA4 9 GLY D 147  ASP D 154  0                                        
SHEET    2 AA4 9 ARG D 122  VAL D 138 -1  N  VAL D 138   O  GLY D 147           
SHEET    3 AA4 9 LEU D  97  SER D 114 -1  N  LYS D  98   O  GLU D 135           
SHEET    4 AA4 9 ILE B  25  ARG B  31 -1  N  TRP B  30   O  GLY D 113           
SHEET    5 AA4 9 LEU B  56  TYR B  61 -1  O  GLU B  59   N  LEU B  28           
SHEET    6 AA4 9 ARG B 122  SER B 128 -1  O  LEU B 127   N  LEU B  56           
SHEET    7 AA4 9 LEU B  97  SER B 114 -1  N  SER B 112   O  ARG B 122           
SHEET    8 AA4 9 THR B 131  VAL B 138 -1  O  GLU B 135   N  LYS B  98           
SHEET    9 AA4 9 GLY B 147  ASP B 154 -1  O  ALA B 151   N  GLN B 134           
SHEET    1 AA5 8 ILE C 149  ASP C 154  0                                        
SHEET    2 AA5 8 ARG C 122  TYR C 136 -1  N  TYR C 136   O  ILE C 149           
SHEET    3 AA5 8 LEU C  56  HIS C  60 -1  N  PHE C  58   O  ILE C 125           
SHEET    4 AA5 8 ILE C  25  ARG C  31 -1  N  LEU C  28   O  GLU C  59           
SHEET    5 AA5 8 GLU F  95  GLY F 113 -1  O  GLY F 113   N  TRP C  30           
SHEET    6 AA5 8 ILE F  79  ARG F  87 -1  N  ILE F  79   O  LEU F 104           
SHEET    7 AA5 8 ASP F   4  ILE F   9 -1  N  ASP F   4   O  ARG F  87           
SHEET    8 AA5 8 ILE F  25  GLU F  26 -1  O  ILE F  25   N  LEU F   7           
SHEET    1 AA6 6 THR F 148  ASP F 154  0                                        
SHEET    2 AA6 6 ARG F 122  VAL F 137 -1  N  GLN F 134   O  ALA F 151           
SHEET    3 AA6 6 GLU F  95  GLY F 113 -1  N  THR F 100   O  LYS F 133           
SHEET    4 AA6 6 ILE F  79  ARG F  87 -1  N  ILE F  79   O  LEU F 104           
SHEET    5 AA6 6 ASP F   4  ILE F   9 -1  N  ASP F   4   O  ARG F  87           
SHEET    6 AA6 6 ILE F  25  GLU F  26 -1  O  ILE F  25   N  LEU F   7           
SHEET    1 AA717 ALA E 151  ASP E 154  0                                        
SHEET    2 AA717 THR E 131  TYR E 136 -1  N  VAL E 132   O  TYR E 153           
SHEET    3 AA717 GLU E  95  SER E 114 -1  N  THR E 100   O  LYS E 133           
SHEET    4 AA717 ARG E 122  SER E 128 -1  O  SER E 128   N  ILE E 105           
SHEET    5 AA717 SER E  57  TYR E  61 -1  N  PHE E  58   O  ILE E 125           
SHEET    6 AA717 ILE E  25  ARG E  31 -1  N  ARG E  31   O  SER E  57           
SHEET    7 AA717 ASP E   4  ILE E   9 -1  N  LEU E   7   O  ILE E  25           
SHEET    8 AA717 HIS E  78  ARG E  87 -1  O  VAL E  85   N  PHE E   6           
SHEET    9 AA717 GLU E  95  SER E 114 -1  O  TYR E  99   N  LEU E  84           
SHEET   10 AA717 ILE A  25  ARG A  31 -1  N  TRP A  30   O  GLY E 113           
SHEET   11 AA717 LEU A  56  TYR A  61 -1  O  GLU A  59   N  LEU A  28           
SHEET   12 AA717 SER A 121  SER A 128 -1  O  GLU A 123   N  HIS A  60           
SHEET   13 AA717 ILE A 105  SER A 114 -1  N  ILE A 105   O  SER A 128           
SHEET   14 AA717 SER D  29  ARG D  31 -1  O  TRP D  30   N  GLY A 113           
SHEET   15 AA717 LEU D  56  TYR D  61 -1  O  GLU D  59   N  SER D  29           
SHEET   16 AA717 ARG D 122  VAL D 138 -1  O  LEU D 127   N  LEU D  56           
SHEET   17 AA717 GLY D 147  ASP D 154 -1  O  GLY D 147   N  VAL D 138           
SHEET    1 AA8 9 ALA E 151  ASP E 154  0                                        
SHEET    2 AA8 9 THR E 131  TYR E 136 -1  N  VAL E 132   O  TYR E 153           
SHEET    3 AA8 9 GLU E  95  SER E 114 -1  N  THR E 100   O  LYS E 133           
SHEET    4 AA8 9 ARG E 122  SER E 128 -1  O  SER E 128   N  ILE E 105           
SHEET    5 AA8 9 SER E  57  TYR E  61 -1  N  PHE E  58   O  ILE E 125           
SHEET    6 AA8 9 ILE E  25  ARG E  31 -1  N  ARG E  31   O  SER E  57           
SHEET    7 AA8 9 GLU C  95  SER C 114 -1  N  GLY C 113   O  TRP E  30           
SHEET    8 AA8 9 ARG C 122  TYR C 136 -1  O  GLU C 126   N  MET C 108           
SHEET    9 AA8 9 ILE C 149  ASP C 154 -1  O  ILE C 149   N  TYR C 136           
CRYST1  102.645  147.786   85.687  90.00 123.74  90.00 C 1 2 1      24          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.009742  0.000000  0.006507        0.00000                         
SCALE2      0.000000  0.006767  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.014034        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system