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Database: PDB
Entry: 5Y3R
LinkDB: 5Y3R
Original site: 5Y3R 
HEADER    DNA BINDING PROTEIN                     29-JUL-17   5Y3R              
TITLE     CRYO-EM STRUCTURE OF HUMAN DNA-PK HOLOENZYME                          
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6;                
COMPND   3 CHAIN: A;                                                            
COMPND   4 FRAGMENT: UNP RESIDUES 34-534;                                       
COMPND   5 SYNONYM: 5'-DEOXYRIBOSE-5-PHOSPHATE LYASE KU70,5'-DRP LYASE KU70,70  
COMPND   6 KDA SUBUNIT OF KU ANTIGEN,ATP-DEPENDENT DNA HELICASE 2 SUBUNIT 1,ATP-
COMPND   7 DEPENDENT DNA HELICASE II 70 KDA SUBUNIT,CTC BOX-BINDING FACTOR 75   
COMPND   8 KDA SUBUNIT,CTCBF,DNA REPAIR PROTEIN XRCC6,LUPUS KU AUTOANTIGEN      
COMPND   9 PROTEIN P70,KU70,THYROID-LUPUS AUTOANTIGEN,TLAA,X-RAY REPAIR         
COMPND  10 COMPLEMENTING DEFECTIVE REPAIR IN CHINESE HAMSTER CELLS 6;           
COMPND  11 EC: 3.6.4.-,4.2.99.-;                                                
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 2;                                                           
COMPND  14 MOLECULE: X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5;                
COMPND  15 CHAIN: B;                                                            
COMPND  16 FRAGMENT: UNP RESIDUES 6-541;                                        
COMPND  17 SYNONYM: 86 KDA SUBUNIT OF KU ANTIGEN,ATP-DEPENDENT DNA HELICASE 2   
COMPND  18 SUBUNIT 2,ATP-DEPENDENT DNA HELICASE II 80 KDA SUBUNIT,CTC BOX-      
COMPND  19 BINDING FACTOR 85 KDA SUBUNIT,CTCBF,DNA REPAIR PROTEIN XRCC5,KU80,   
COMPND  20 KU86,LUPUS KU AUTOANTIGEN PROTEIN P86,NUCLEAR FACTOR IV,THYROID-LUPUS
COMPND  21 AUTOANTIGEN,TLAA,X-RAY REPAIR COMPLEMENTING DEFECTIVE REPAIR IN      
COMPND  22 CHINESE HAMSTER CELLS 5 (DOUBLE-STRAND-BREAK REJOINING);             
COMPND  23 EC: 3.6.4.-;                                                         
COMPND  24 ENGINEERED: YES;                                                     
COMPND  25 MOL_ID: 3;                                                           
COMPND  26 MOLECULE: PRKDC-HELIX;                                               
COMPND  27 CHAIN: K;                                                            
COMPND  28 ENGINEERED: YES;                                                     
COMPND  29 MOL_ID: 4;                                                           
COMPND  30 MOLECULE: DNA (34-MER);                                              
COMPND  31 CHAIN: D;                                                            
COMPND  32 ENGINEERED: YES;                                                     
COMPND  33 MOL_ID: 5;                                                           
COMPND  34 MOLECULE: DNA (36-MER);                                              
COMPND  35 CHAIN: E;                                                            
COMPND  36 ENGINEERED: YES;                                                     
COMPND  37 MOL_ID: 6;                                                           
COMPND  38 MOLECULE: DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT;            
COMPND  39 CHAIN: C;                                                            
COMPND  40 FRAGMENT: UNP RESIDUES 10-4128;                                      
COMPND  41 SYNONYM: DNA-PKCS,DNPK1,P460;                                        
COMPND  42 EC: 2.7.11.1;                                                        
COMPND  43 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: XRCC6, G22P1;                                                  
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: XRCC5, G22P2;                                                  
SOURCE  13 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_TAXID: 9606;                                                
SOURCE  18 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  19 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  20 MOL_ID: 4;                                                           
SOURCE  21 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  22 ORGANISM_TAXID: 9606;                                                
SOURCE  23 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  24 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  25 MOL_ID: 5;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_TAXID: 9606;                                                
SOURCE  28 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  29 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  30 MOL_ID: 6;                                                           
SOURCE  31 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  32 ORGANISM_COMMON: HUMAN;                                              
SOURCE  33 ORGANISM_TAXID: 9606;                                                
SOURCE  34 GENE: PRKDC, HYRC, HYRC1;                                            
SOURCE  35 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  36 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  37 EXPRESSION_SYSTEM_CELL_LINE: HEK293F;                                
SOURCE  38 EXPRESSION_SYSTEM_ORGAN: KIDNEY                                      
KEYWDS    CRYO-EM STRUCTURE, DNA-PK, DNAPKCS, ACTIVATION, NHEJ, DNA BINDING     
KEYWDS   2 PROTEIN                                                              
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    X.YIN,M.LIU,Y.TIAN,J.WANG,Y.XU                                        
REVDAT   4   09-OCT-19 5Y3R    1       CRYST1 SCALE                             
REVDAT   3   13-JUN-18 5Y3R    1       SOURCE                                   
REVDAT   2   15-NOV-17 5Y3R    1       JRNL                                     
REVDAT   1   06-SEP-17 5Y3R    0                                                
JRNL        AUTH   X.YIN,M.LIU,Y.TIAN,J.WANG,Y.XU                               
JRNL        TITL   CRYO-EM STRUCTURE OF HUMAN DNA-PK HOLOENZYME                 
JRNL        REF    CELL RES.                     V.  27  1341 2017              
JRNL        REFN                   ISSN 1748-7838                               
JRNL        PMID   28840859                                                     
JRNL        DOI    10.1038/CR.2017.110                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    6.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION, CTFFIND3, RELION, RELION,         
REMARK   3                            RELION                                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 6.600                          
REMARK   3   NUMBER OF PARTICLES               : 53451                          
REMARK   3   CTF CORRECTION METHOD             : NONE                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5Y3R COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 01-AUG-17.                  
REMARK 100 THE DEPOSITION ID IS D_1300004603.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : PRKDC-HELIX                       
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.60                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.40                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 3496                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : 1700.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 4700.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 50.00                          
REMARK 245   ILLUMINATION MODE                 : OTHER                          
REMARK 245   NOMINAL MAGNIFICATION             : 18000                          
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, K, D, E, C                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ILE A   223                                                      
REMARK 465     ALA A   224                                                      
REMARK 465     GLU A   225                                                      
REMARK 465     ASP A   226                                                      
REMARK 465     GLU A   227                                                      
REMARK 465     ASP A   228                                                      
REMARK 465     LEU A   229                                                      
REMARK 465     ARG A   230                                                      
REMARK 465     LYS B   171                                                      
REMARK 465     GLU B   172                                                      
REMARK 465     ASP B   173                                                      
REMARK 465     GLY B   174                                                      
REMARK 465     SER B   175                                                      
REMARK 465     GLY B   176                                                      
REMARK 465     ASP B   177                                                      
REMARK 465     ARG B   178                                                      
REMARK 465     GLY B   179                                                      
REMARK 465     ASP B   180                                                      
REMARK 465     PRO C   498                                                      
REMARK 465     LYS C   499                                                      
REMARK 465     GLY C   500                                                      
REMARK 465     PRO C   501                                                      
REMARK 465     GLU C   502                                                      
REMARK 465     SER C   503                                                      
REMARK 465     GLU C   504                                                      
REMARK 465     SER C   505                                                      
REMARK 465     GLU C   506                                                      
REMARK 465     ASP C   507                                                      
REMARK 465     HIS C   508                                                      
REMARK 465     ARG C   509                                                      
REMARK 465     ALA C   510                                                      
REMARK 465     SER C   511                                                      
REMARK 465     GLY C   512                                                      
REMARK 465     GLU C   513                                                      
REMARK 465     VAL C   514                                                      
REMARK 465     ARG C   515                                                      
REMARK 465     THR C   516                                                      
REMARK 465     GLY C   517                                                      
REMARK 465     LYS C   518                                                      
REMARK 465     TRP C   519                                                      
REMARK 465     LYS C   520                                                      
REMARK 465     VAL C   521                                                      
REMARK 465     PRO C   522                                                      
REMARK 465     THR C   523                                                      
REMARK 465     TYR C   524                                                      
REMARK 465     PHE C   683                                                      
REMARK 465     GLU C   684                                                      
REMARK 465     GLY C   685                                                      
REMARK 465     VAL C   686                                                      
REMARK 465     SER C   687                                                      
REMARK 465     PRO C   688                                                      
REMARK 465     LYS C   689                                                      
REMARK 465     SER C   690                                                      
REMARK 465     LEU C   691                                                      
REMARK 465     LYS C   692                                                      
REMARK 465     HIS C   693                                                      
REMARK 465     SER C   694                                                      
REMARK 465     PRO C   695                                                      
REMARK 465     GLU C   696                                                      
REMARK 465     ASP C   697                                                      
REMARK 465     PRO C   698                                                      
REMARK 465     GLU C   699                                                      
REMARK 465     LYS C   810                                                      
REMARK 465     ASN C   811                                                      
REMARK 465     ASN C   812                                                      
REMARK 465     TRP C   813                                                      
REMARK 465     GLU C   814                                                      
REMARK 465     VAL C   815                                                      
REMARK 465     SER C   816                                                      
REMARK 465     ALA C   817                                                      
REMARK 465     LEU C   818                                                      
REMARK 465     SER C   819                                                      
REMARK 465     ARG C   820                                                      
REMARK 465     ALA C   821                                                      
REMARK 465     ALA C   822                                                      
REMARK 465     GLN C   823                                                      
REMARK 465     LYS C   824                                                      
REMARK 465     GLY C   825                                                      
REMARK 465     PHE C   826                                                      
REMARK 465     ASN C   827                                                      
REMARK 465     LYS C   828                                                      
REMARK 465     VAL C   829                                                      
REMARK 465     VAL C   830                                                      
REMARK 465     LEU C   831                                                      
REMARK 465     LYS C   832                                                      
REMARK 465     HIS C   833                                                      
REMARK 465     LEU C   834                                                      
REMARK 465     LYS C   835                                                      
REMARK 465     LYS C   836                                                      
REMARK 465     THR C   837                                                      
REMARK 465     LYS C   838                                                      
REMARK 465     ASN C   839                                                      
REMARK 465     LEU C   840                                                      
REMARK 465     SER C   841                                                      
REMARK 465     SER C   842                                                      
REMARK 465     ASN C   843                                                      
REMARK 465     GLU C   844                                                      
REMARK 465     ALA C   845                                                      
REMARK 465     THR C  1181                                                      
REMARK 465     GLU C  1182                                                      
REMARK 465     CYS C  1183                                                      
REMARK 465     ARG C  1184                                                      
REMARK 465     HIS C  1185                                                      
REMARK 465     LYS C  1186                                                      
REMARK 465     SER C  1187                                                      
REMARK 465     ILE C  1188                                                      
REMARK 465     GLU C  1189                                                      
REMARK 465     LEU C  1190                                                      
REMARK 465     PHE C  1191                                                      
REMARK 465     TYR C  1192                                                      
REMARK 465     LYS C  1193                                                      
REMARK 465     PHE C  1194                                                      
REMARK 465     VAL C  1195                                                      
REMARK 465     PRO C  1196                                                      
REMARK 465     LEU C  1197                                                      
REMARK 465     LEU C  1198                                                      
REMARK 465     PRO C  1199                                                      
REMARK 465     GLY C  1200                                                      
REMARK 465     ASN C  1201                                                      
REMARK 465     ARG C  1202                                                      
REMARK 465     SER C  1203                                                      
REMARK 465     PRO C  1204                                                      
REMARK 465     ASN C  1205                                                      
REMARK 465     LEU C  1206                                                      
REMARK 465     TRP C  1207                                                      
REMARK 465     LEU C  1208                                                      
REMARK 465     LYS C  1209                                                      
REMARK 465     ASP C  1210                                                      
REMARK 465     VAL C  1211                                                      
REMARK 465     LEU C  1212                                                      
REMARK 465     ALA C  1309                                                      
REMARK 465     GLU C  1310                                                      
REMARK 465     LYS C  1311                                                      
REMARK 465     CYS C  1312                                                      
REMARK 465     PHE C  1313                                                      
REMARK 465     GLY C  1314                                                      
REMARK 465     THR C  1315                                                      
REMARK 465     GLY C  1316                                                      
REMARK 465     ALA C  1317                                                      
REMARK 465     ALA C  1318                                                      
REMARK 465     GLY C  1319                                                      
REMARK 465     ASN C  1320                                                      
REMARK 465     ARG C  1321                                                      
REMARK 465     THR C  1322                                                      
REMARK 465     ARG C  1527                                                      
REMARK 465     LEU C  1528                                                      
REMARK 465     VAL C  1529                                                      
REMARK 465     SER C  1530                                                      
REMARK 465     LEU C  1531                                                      
REMARK 465     LEU C  1532                                                      
REMARK 465     LEU C  1533                                                      
REMARK 465     ASN C  1534                                                      
REMARK 465     PRO C  1535                                                      
REMARK 465     ALA C  1536                                                      
REMARK 465     VAL C  1537                                                      
REMARK 465     LEU C  1538                                                      
REMARK 465     SER C  1539                                                      
REMARK 465     THR C  1540                                                      
REMARK 465     ALA C  1541                                                      
REMARK 465     SER C  1542                                                      
REMARK 465     LEU C  1543                                                      
REMARK 465     GLY C  1544                                                      
REMARK 465     SER C  1545                                                      
REMARK 465     SER C  1546                                                      
REMARK 465     GLN C  1547                                                      
REMARK 465     ASN C  1610                                                      
REMARK 465     GLN C  1611                                                      
REMARK 465     LYS C  1612                                                      
REMARK 465     HIS C  1613                                                      
REMARK 465     GLN C  1614                                                      
REMARK 465     GLY C  1615                                                      
REMARK 465     LEU C  1616                                                      
REMARK 465     LYS C  1617                                                      
REMARK 465     LEU C  1618                                                      
REMARK 465     ALA C  1619                                                      
REMARK 465     THR C  1620                                                      
REMARK 465     THR C  1621                                                      
REMARK 465     ILE C  1622                                                      
REMARK 465     LEU C  1623                                                      
REMARK 465     GLN C  1624                                                      
REMARK 465     HIS C  1625                                                      
REMARK 465     TRP C  1626                                                      
REMARK 465     LYS C  1627                                                      
REMARK 465     LYS C  1628                                                      
REMARK 465     CYS C  1629                                                      
REMARK 465     VAL C  1659                                                      
REMARK 465     SER C  1660                                                      
REMARK 465     PHE C  1661                                                      
REMARK 465     ASN C  1662                                                      
REMARK 465     THR C  1663                                                      
REMARK 465     SER C  1664                                                      
REMARK 465     HIS C  1665                                                      
REMARK 465     GLY C  1666                                                      
REMARK 465     SER C  1667                                                      
REMARK 465     PHE C  1668                                                      
REMARK 465     PRO C  1669                                                      
REMARK 465     GLU C  1670                                                      
REMARK 465     GLU C  1764                                                      
REMARK 465     VAL C  1765                                                      
REMARK 465     LEU C  1766                                                      
REMARK 465     CYS C  1767                                                      
REMARK 465     ARG C  1768                                                      
REMARK 465     GLU C  1769                                                      
REMARK 465     GLN C  1770                                                      
REMARK 465     GLN C  1771                                                      
REMARK 465     HIS C  1772                                                      
REMARK 465     VAL C  1773                                                      
REMARK 465     MET C  1774                                                      
REMARK 465     GLU C  1775                                                      
REMARK 465     GLU C  1776                                                      
REMARK 465     LEU C  1777                                                      
REMARK 465     PHE C  1778                                                      
REMARK 465     GLN C  1779                                                      
REMARK 465     SER C  1780                                                      
REMARK 465     SER C  1781                                                      
REMARK 465     PHE C  1782                                                      
REMARK 465     ARG C  1783                                                      
REMARK 465     ARG C  1784                                                      
REMARK 465     ILE C  1785                                                      
REMARK 465     ALA C  1786                                                      
REMARK 465     ARG C  1787                                                      
REMARK 465     ARG C  1788                                                      
REMARK 465     GLY C  1789                                                      
REMARK 465     SER C  1790                                                      
REMARK 465     CYS C  1791                                                      
REMARK 465     VAL C  1792                                                      
REMARK 465     THR C  1793                                                      
REMARK 465     GLN C  1794                                                      
REMARK 465     VAL C  1795                                                      
REMARK 465     GLY C  1796                                                      
REMARK 465     LEU C  1797                                                      
REMARK 465     SER C  1823                                                      
REMARK 465     LEU C  1824                                                      
REMARK 465     LEU C  1825                                                      
REMARK 465     THR C  1826                                                      
REMARK 465     LEU C  1827                                                      
REMARK 465     LEU C  1828                                                      
REMARK 465     TRP C  1829                                                      
REMARK 465     HIS C  1830                                                      
REMARK 465     CYS C  1831                                                      
REMARK 465     SER C  1832                                                      
REMARK 465     LEU C  1833                                                      
REMARK 465     ASP C  1834                                                      
REMARK 465     ALA C  1835                                                      
REMARK 465     LEU C  1836                                                      
REMARK 465     ARG C  1837                                                      
REMARK 465     GLU C  1838                                                      
REMARK 465     PHE C  1839                                                      
REMARK 465     PHE C  1840                                                      
REMARK 465     SER C  1841                                                      
REMARK 465     THR C  1842                                                      
REMARK 465     ILE C  1843                                                      
REMARK 465     VAL C  1844                                                      
REMARK 465     VAL C  1845                                                      
REMARK 465     ASP C  1846                                                      
REMARK 465     ALA C  1847                                                      
REMARK 465     ILE C  1848                                                      
REMARK 465     ASP C  1849                                                      
REMARK 465     VAL C  1850                                                      
REMARK 465     LEU C  1851                                                      
REMARK 465     LYS C  1852                                                      
REMARK 465     SER C  1853                                                      
REMARK 465     ARG C  1854                                                      
REMARK 465     PHE C  1855                                                      
REMARK 465     PHE C  2577                                                      
REMARK 465     GLU C  2578                                                      
REMARK 465     HIS C  2579                                                      
REMARK 465     PRO C  2580                                                      
REMARK 465     LEU C  2581                                                      
REMARK 465     SER C  2582                                                      
REMARK 465     GLU C  2583                                                      
REMARK 465     CYS C  2584                                                      
REMARK 465     GLU C  2585                                                      
REMARK 465     PHE C  2586                                                      
REMARK 465     GLN C  2587                                                      
REMARK 465     GLU C  2588                                                      
REMARK 465     TYR C  2589                                                      
REMARK 465     THR C  2590                                                      
REMARK 465     ILE C  2591                                                      
REMARK 465     ASP C  2592                                                      
REMARK 465     SER C  2593                                                      
REMARK 465     ASP C  2594                                                      
REMARK 465     TRP C  2595                                                      
REMARK 465     ARG C  2596                                                      
REMARK 465     PHE C  2597                                                      
REMARK 465     ARG C  2598                                                      
REMARK 465     SER C  2599                                                      
REMARK 465     THR C  2600                                                      
REMARK 465     VAL C  2601                                                      
REMARK 465     LEU C  2602                                                      
REMARK 465     THR C  2603                                                      
REMARK 465     PRO C  2604                                                      
REMARK 465     MET C  2605                                                      
REMARK 465     PHE C  2606                                                      
REMARK 465     VAL C  2607                                                      
REMARK 465     GLU C  2608                                                      
REMARK 465     THR C  2609                                                      
REMARK 465     GLN C  2610                                                      
REMARK 465     ALA C  2611                                                      
REMARK 465     SER C  2612                                                      
REMARK 465     GLN C  2613                                                      
REMARK 465     GLY C  2614                                                      
REMARK 465     THR C  2615                                                      
REMARK 465     LEU C  2616                                                      
REMARK 465     GLN C  2617                                                      
REMARK 465     THR C  2618                                                      
REMARK 465     ARG C  2619                                                      
REMARK 465     THR C  2620                                                      
REMARK 465     GLN C  2621                                                      
REMARK 465     GLU C  2622                                                      
REMARK 465     GLY C  2623                                                      
REMARK 465     SER C  2624                                                      
REMARK 465     LEU C  2625                                                      
REMARK 465     SER C  2626                                                      
REMARK 465     ALA C  2627                                                      
REMARK 465     ARG C  2628                                                      
REMARK 465     TRP C  2629                                                      
REMARK 465     PRO C  2630                                                      
REMARK 465     VAL C  2631                                                      
REMARK 465     ALA C  2632                                                      
REMARK 465     GLY C  2633                                                      
REMARK 465     GLN C  2634                                                      
REMARK 465     ILE C  2635                                                      
REMARK 465     ARG C  2636                                                      
REMARK 465     ALA C  2637                                                      
REMARK 465     THR C  2638                                                      
REMARK 465     GLN C  2639                                                      
REMARK 465     GLN C  2640                                                      
REMARK 465     GLN C  2641                                                      
REMARK 465     HIS C  2642                                                      
REMARK 465     ASP C  2643                                                      
REMARK 465     PHE C  2644                                                      
REMARK 465     THR C  2645                                                      
REMARK 465     LEU C  2646                                                      
REMARK 465     THR C  2647                                                      
REMARK 465     GLN C  2648                                                      
REMARK 465     THR C  2649                                                      
REMARK 465     ALA C  2650                                                      
REMARK 465     ASP C  2651                                                      
REMARK 465     GLY C  2652                                                      
REMARK 465     ARG C  2653                                                      
REMARK 465     SER C  2654                                                      
REMARK 465     SER C  2655                                                      
REMARK 465     PHE C  2656                                                      
REMARK 465     ASP C  2657                                                      
REMARK 465     TRP C  2658                                                      
REMARK 465     LEU C  2659                                                      
REMARK 465     THR C  2660                                                      
REMARK 465     GLY C  2661                                                      
REMARK 465     SER C  2662                                                      
REMARK 465     SER C  2663                                                      
REMARK 465     THR C  2664                                                      
REMARK 465     ASP C  2665                                                      
REMARK 465     PRO C  2666                                                      
REMARK 465     LEU C  2667                                                      
REMARK 465     VAL C  2668                                                      
REMARK 465     ASP C  2669                                                      
REMARK 465     HIS C  2670                                                      
REMARK 465     THR C  2671                                                      
REMARK 465     SER C  2672                                                      
REMARK 465     PRO C  2673                                                      
REMARK 465     SER C  2674                                                      
REMARK 465     SER C  2675                                                      
REMARK 465     ASP C  2676                                                      
REMARK 465     SER C  2677                                                      
REMARK 465     LEU C  2678                                                      
REMARK 465     LEU C  2679                                                      
REMARK 465     PHE C  2680                                                      
REMARK 465     ALA C  2681                                                      
REMARK 465     HIS C  2682                                                      
REMARK 465     LYS C  2683                                                      
REMARK 465     ARG C  2684                                                      
REMARK 465     SER C  2685                                                      
REMARK 465     GLU C  2686                                                      
REMARK 465     ARG C  2687                                                      
REMARK 465     LEU C  2688                                                      
REMARK 465     GLN C  2689                                                      
REMARK 465     ARG C  2690                                                      
REMARK 465     ALA C  2691                                                      
REMARK 465     PRO C  2692                                                      
REMARK 465     LEU C  2693                                                      
REMARK 465     LYS C  2694                                                      
REMARK 465     SER C  2695                                                      
REMARK 465     VAL C  2696                                                      
REMARK 465     GLY C  2697                                                      
REMARK 465     PRO C  2698                                                      
REMARK 465     ASP C  2699                                                      
REMARK 465     PHE C  2700                                                      
REMARK 465     GLY C  2701                                                      
REMARK 465     LYS C  2702                                                      
REMARK 465     LYS C  2703                                                      
REMARK 465     ARG C  2704                                                      
REMARK 465     LEU C  2705                                                      
REMARK 465     GLY C  2706                                                      
REMARK 465     LEU C  2707                                                      
REMARK 465     PRO C  2708                                                      
REMARK 465     GLY C  2709                                                      
REMARK 465     ASP C  2710                                                      
REMARK 465     GLU C  2711                                                      
REMARK 465     VAL C  2712                                                      
REMARK 465     ASP C  2713                                                      
REMARK 465     ASN C  2714                                                      
REMARK 465     LYS C  2715                                                      
REMARK 465     VAL C  2716                                                      
REMARK 465     LYS C  2717                                                      
REMARK 465     GLY C  2718                                                      
REMARK 465     ALA C  2719                                                      
REMARK 465     ALA C  2720                                                      
REMARK 465     GLY C  2721                                                      
REMARK 465     ARG C  2722                                                      
REMARK 465     THR C  2723                                                      
REMARK 465     ASP C  2724                                                      
REMARK 465     LEU C  2725                                                      
REMARK 465     LEU C  2726                                                      
REMARK 465     ARG C  2727                                                      
REMARK 465     LEU C  2728                                                      
REMARK 465     ARG C  2729                                                      
REMARK 465     ARG C  2730                                                      
REMARK 465     ARG C  2731                                                      
REMARK 465     PHE C  2732                                                      
REMARK 465     MET C  2733                                                      
REMARK 465     ARG C  2734                                                      
REMARK 465     ASP C  2735                                                      
REMARK 465     GLN C  2736                                                      
REMARK 465     GLU C  2737                                                      
REMARK 465     LYS C  2738                                                      
REMARK 465     LEU C  2739                                                      
REMARK 465     SER C  2740                                                      
REMARK 465     LEU C  2741                                                      
REMARK 465     MET C  2742                                                      
REMARK 465     TYR C  2743                                                      
REMARK 465     ALA C  2744                                                      
REMARK 465     ARG C  2745                                                      
REMARK 465     LYS C  2746                                                      
REMARK 465     GLY C  2747                                                      
REMARK 465     VAL C  2748                                                      
REMARK 465     ALA C  2749                                                      
REMARK 465     GLU C  2750                                                      
REMARK 465     GLN C  2751                                                      
REMARK 465     LYS C  2752                                                      
REMARK 465     ARG C  2753                                                      
REMARK 465     GLU C  2754                                                      
REMARK 465     LYS C  2755                                                      
REMARK 465     GLU C  2756                                                      
REMARK 465     ILE C  2757                                                      
REMARK 465     LYS C  2758                                                      
REMARK 465     SER C  2759                                                      
REMARK 465     GLU C  2760                                                      
REMARK 465     LEU C  2761                                                      
REMARK 465     LYS C  2762                                                      
REMARK 465     MET C  2763                                                      
REMARK 465     LYS C  2764                                                      
REMARK 465     GLN C  2765                                                      
REMARK 465     ASP C  2766                                                      
REMARK 465     ALA C  2767                                                      
REMARK 465     GLN C  2768                                                      
REMARK 465     VAL C  2769                                                      
REMARK 465     VAL C  2770                                                      
REMARK 465     LEU C  2771                                                      
REMARK 465     TYR C  2772                                                      
REMARK 465     ARG C  2773                                                      
REMARK 465     LEU C  3200                                                      
REMARK 465     PRO C  3201                                                      
REMARK 465     GLU C  3202                                                      
REMARK 465     ASP C  3203                                                      
REMARK 465     ASN C  3204                                                      
REMARK 465     SER C  3205                                                      
REMARK 465     MET C  3206                                                      
REMARK 465     ASN C  3207                                                      
REMARK 465     VAL C  3208                                                      
REMARK 465     ASP C  3209                                                      
REMARK 465     GLN C  3210                                                      
REMARK 465     ASP C  3211                                                      
REMARK 465     GLY C  3212                                                      
REMARK 465     ASP C  3213                                                      
REMARK 465     PRO C  3214                                                      
REMARK 465     SER C  3215                                                      
REMARK 465     ASP C  3216                                                      
REMARK 465     ARG C  3217                                                      
REMARK 465     MET C  3218                                                      
REMARK 465     GLU C  3219                                                      
REMARK 465     VAL C  3220                                                      
REMARK 465     GLN C  3221                                                      
REMARK 465     GLU C  3222                                                      
REMARK 465     GLN C  3223                                                      
REMARK 465     GLU C  3224                                                      
REMARK 465     GLU C  3225                                                      
REMARK 465     ASP C  3226                                                      
REMARK 465     LEU C  3360                                                      
REMARK 465     GLU C  3361                                                      
REMARK 465     LEU C  3362                                                      
REMARK 465     SER C  3363                                                      
REMARK 465     GLY C  3364                                                      
REMARK 465     SER C  3365                                                      
REMARK 465     SER C  3366                                                      
REMARK 465     SER C  3367                                                      
REMARK 465     GLU C  3368                                                      
REMARK 465     ASP C  3369                                                      
REMARK 465     SER C  3370                                                      
REMARK 465     GLU C  3371                                                      
REMARK 465     LYS C  3372                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   N2    DG D     9     O2    DC E    27              1.89            
REMARK 500   O2    DC D    11     N2    DG E    25              1.90            
REMARK 500   O    PHE C  3904     OG   SER C  3907              1.91            
REMARK 500   O    LEU C  2364     OG1  THR C  2368              1.91            
REMARK 500   O    ASP C  3181     OG1  THR C  3184              1.92            
REMARK 500   O    ILE C  2237     OG1  THR C  2240              1.93            
REMARK 500   O    ILE C   443     OH   TYR C   449              1.93            
REMARK 500   O    TRP C  2994     OG   SER C  2998              1.94            
REMARK 500   O    MET C  2281     OH   TYR C  2329              1.95            
REMARK 500   OH   TYR A    71     OD2  ASP A   109              1.96            
REMARK 500   O    GLN C    16     OG   SER C    20              1.96            
REMARK 500   N2    DG D     1     O2    DC E    35              1.96            
REMARK 500   O    PHE C   620     NH1  ARG C   659              1.96            
REMARK 500   O    SER C  3537     OG   SER C  3541              1.97            
REMARK 500   N2    DG D    10     O2    DC E    26              1.98            
REMARK 500   O    ALA C    52     OG1  THR C    55              1.98            
REMARK 500   O    ARG A   247     NH2  ARG A   488              1.98            
REMARK 500   O    SER A   184     OG1  THR A   188              1.98            
REMARK 500   O    LEU C   534     OG   SER C   537              1.98            
REMARK 500   NH1  ARG C  2522     OG   SER C  2526              1.98            
REMARK 500   O    ASP C  3411     OG1  THR C  3415              1.99            
REMARK 500   O    HIS C  2225     N    ARG C  2228              1.99            
REMARK 500   O    SER B   226     OG   SER B   230              2.00            
REMARK 500   O    ASN C  2305     OG   SER C  2308              2.00            
REMARK 500   O    LEU C  3329     OG1  THR C  3333              2.00            
REMARK 500   O    ALA C  2095     OG1  THR C  2098              2.00            
REMARK 500   O    GLN B   450     NZ   LYS B   532              2.01            
REMARK 500   O    ALA C  3862     OG1  THR C  3865              2.01            
REMARK 500   N    LEU B   343     O    ILE B   392              2.01            
REMARK 500   O    PHE B   167     OG   SER B   226              2.01            
REMARK 500   OD1  ASN C  1946     OG   SER C  1950              2.01            
REMARK 500   NE2  GLN C  3130     OD2  ASP C  3181              2.02            
REMARK 500   O    VAL C  2242     NZ   LYS C  2246              2.02            
REMARK 500   O    ALA C  2989     N    PHE C  2993              2.02            
REMARK 500   O    PRO C   986     NH1  ARG C  2776              2.02            
REMARK 500   O    GLU C  2406     OG1  THR C  2409              2.02            
REMARK 500   O    CYS C    10     N    ARG C    14              2.02            
REMARK 500   O    LEU C  2235     N    ILE C  2238              2.03            
REMARK 500   OE1  GLU C  2180     OH   TYR C  2184              2.03            
REMARK 500   O    ASN C  2830     OG1  THR C  2833              2.03            
REMARK 500   O    LEU C  3283     N    CYS C  3286              2.03            
REMARK 500   O    THR C  1481     OG   SER C  1485              2.03            
REMARK 500   O    PHE C  1699     OG1  THR C  1703              2.03            
REMARK 500   OG   SER A   319     OE1  GLN A   326              2.03            
REMARK 500   O    ARG C   364     N    LEU C   368              2.04            
REMARK 500   O    SER C  1861     OG1  THR C  1865              2.04            
REMARK 500   O    LEU C  1678     OG1  THR C  1682              2.04            
REMARK 500   O    ARG A   254     OH   TYR B   433              2.04            
REMARK 500   OG   SER C  3083     OE1  GLU C  3085              2.04            
REMARK 500   OG1  THR A   316     O    VAL B   278              2.04            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     293 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500     DT D   0   O3'    DT D   0   C3'    -0.037                       
REMARK 500     DG D   2   O3'    DG D   2   C3'    -0.056                       
REMARK 500     DC E  26   O3'    DC E  26   C3'    -0.043                       
REMARK 500     DT E  37   O3'    DT E  37   C3'    -0.043                       
REMARK 500     DA E  38   O3'    DA E  38   C3'    -0.047                       
REMARK 500     DA E  39   O3'    DA E  39   C3'    -0.051                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A 153   CA  -  CB  -  CG  ANGL. DEV. = -14.5 DEGREES          
REMARK 500    LEU B 476   CA  -  CB  -  CG  ANGL. DEV. = -14.8 DEGREES          
REMARK 500     DG D   2   O4' -  C4' -  C3' ANGL. DEV. =  -3.1 DEGREES          
REMARK 500     DT D   5   O4' -  C4' -  C3' ANGL. DEV. =  -2.5 DEGREES          
REMARK 500     DC D  12   O4' -  C1' -  N1  ANGL. DEV. =   2.2 DEGREES          
REMARK 500     DA E  17   O4' -  C1' -  N9  ANGL. DEV. =   4.0 DEGREES          
REMARK 500     DA E  36   O3' -  P   -  OP1 ANGL. DEV. =   7.2 DEGREES          
REMARK 500     DA E  36   C3' -  C2' -  C1' ANGL. DEV. =  -6.0 DEGREES          
REMARK 500     DA E  39   O4' -  C4' -  C3' ANGL. DEV. =  -3.0 DEGREES          
REMARK 500     DA E  41   C3' -  C2' -  C1' ANGL. DEV. =  -5.1 DEGREES          
REMARK 500     DA E  44   O4' -  C4' -  C3' ANGL. DEV. =  -3.6 DEGREES          
REMARK 500     DA E  44   O4' -  C1' -  N9  ANGL. DEV. =   2.7 DEGREES          
REMARK 500     DG E  45   O4' -  C1' -  N9  ANGL. DEV. =   2.2 DEGREES          
REMARK 500    LEU C  66   CA  -  CB  -  CG  ANGL. DEV. = -13.9 DEGREES          
REMARK 500    LEU C 313   CA  -  CB  -  CG  ANGL. DEV. = -14.9 DEGREES          
REMARK 500    PRO C 473   C   -  N   -  CA  ANGL. DEV. =  14.6 DEGREES          
REMARK 500    PRO C 473   C   -  N   -  CD  ANGL. DEV. = -13.5 DEGREES          
REMARK 500    LEU C 634   CA  -  CB  -  CG  ANGL. DEV. =  14.5 DEGREES          
REMARK 500    ARG C 659   NE  -  CZ  -  NH2 ANGL. DEV. =   3.1 DEGREES          
REMARK 500    LEU C 734   CA  -  CB  -  CG  ANGL. DEV. = -20.2 DEGREES          
REMARK 500    LEU C1025   CA  -  CB  -  CG  ANGL. DEV. = -18.3 DEGREES          
REMARK 500    LEU C1165   CA  -  CB  -  CG  ANGL. DEV. =  17.9 DEGREES          
REMARK 500    LEU C1257   CA  -  CB  -  CG  ANGL. DEV. = -18.6 DEGREES          
REMARK 500    LEU C1259   CA  -  CB  -  CG  ANGL. DEV. =  14.8 DEGREES          
REMARK 500    LEU C2276   CA  -  CB  -  CG  ANGL. DEV. = -15.1 DEGREES          
REMARK 500    LEU C2323   CA  -  CB  -  CG  ANGL. DEV. = -20.9 DEGREES          
REMARK 500    PRO C2373   C   -  N   -  CA  ANGL. DEV. =  -9.0 DEGREES          
REMARK 500    ARG C2427   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.5 DEGREES          
REMARK 500    LEU C2557   CA  -  CB  -  CG  ANGL. DEV. = -15.2 DEGREES          
REMARK 500    LEU C2884   CA  -  CB  -  CG  ANGL. DEV. = -18.3 DEGREES          
REMARK 500    LEU C2939   CA  -  CB  -  CG  ANGL. DEV. = -14.9 DEGREES          
REMARK 500    ARG C3125   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.5 DEGREES          
REMARK 500    LEU C3463   CA  -  CB  -  CG  ANGL. DEV. = -14.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER A  45      -78.46   -102.47                                   
REMARK 500    LYS A  46      -67.90   -138.19                                   
REMARK 500    GLU A  56      -73.21   -101.38                                   
REMARK 500    GLU A  91      -74.01    -76.29                                   
REMARK 500    LEU A 105      -63.99   -109.94                                   
REMARK 500    GLN A 128      -70.50    -51.68                                   
REMARK 500    GLN A 132      -76.08    -53.11                                   
REMARK 500    SER A 139      -65.49   -144.49                                   
REMARK 500    LEU A 143      -74.10    -59.86                                   
REMARK 500    VAL A 149      -71.80    -61.06                                   
REMARK 500    SER A 162      -66.57   -132.24                                   
REMARK 500    HIS A 176      150.23    178.61                                   
REMARK 500    THR A 188      -73.64    -96.57                                   
REMARK 500    LYS A 206       73.43     67.36                                   
REMARK 500    PHE A 211      151.66    178.73                                   
REMARK 500    SER A 214      -78.76   -120.95                                   
REMARK 500    LEU A 215     -131.43     41.70                                   
REMARK 500    ARG A 218      -56.21   -137.88                                   
REMARK 500    LEU A 243      -74.58    -49.32                                   
REMARK 500    ARG A 252      -76.04   -119.67                                   
REMARK 500    LEU A 256      -89.05   -125.89                                   
REMARK 500    LEU A 263      -71.42    -75.51                                   
REMARK 500    LYS A 279       68.56     63.49                                   
REMARK 500    ARG A 290     -131.58     37.97                                   
REMARK 500    ASN A 293      -13.01     72.24                                   
REMARK 500    SER A 306      -75.61   -103.77                                   
REMARK 500    PHE A 340      -62.80   -121.52                                   
REMARK 500    ASP A 341      -79.19   -119.05                                   
REMARK 500    ASP A 342      153.49    170.76                                   
REMARK 500    LYS A 357      -80.24   -101.52                                   
REMARK 500    HIS A 360      157.90    177.98                                   
REMARK 500    TYR A 361      156.59    176.03                                   
REMARK 500    LEU A 362     -166.07   -164.76                                   
REMARK 500    SER A 373      -62.60   -142.61                                   
REMARK 500    SER A 383      -72.10    -57.29                                   
REMARK 500    PRO A 402     -176.50    -58.42                                   
REMARK 500    ARG A 404       65.51     38.79                                   
REMARK 500    ASN A 405     -153.35     51.01                                   
REMARK 500    ILE A 406      171.40    158.41                                   
REMARK 500    LYS A 424       49.27     72.63                                   
REMARK 500    MET A 446      134.22   -174.16                                   
REMARK 500    TYR A 473     -148.16     57.90                                   
REMARK 500    ARG A 474      176.45    172.50                                   
REMARK 500    ASN A 480       76.77   -115.74                                   
REMARK 500    ALA A 492      -71.44    -54.32                                   
REMARK 500    PRO A 500      179.37    -59.51                                   
REMARK 500    LYS A 516      -74.13    -92.30                                   
REMARK 500    LEU A 528      -71.13    -52.30                                   
REMARK 500    ASN B  66      159.44    178.39                                   
REMARK 500    ASP B  72      -18.23     80.07                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     569 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ARG A   35     ASP A   36                 -141.92                    
REMARK 500 ILE A  102     TYR A  103                  148.41                    
REMARK 500 ASP A  109     ASN A  110                  145.58                    
REMARK 500 LYS A  206     LYS A  207                  135.38                    
REMARK 500 VAL A  268     ILE A  269                  149.74                    
REMARK 500 GLN A  278     LYS A  279                 -147.38                    
REMARK 500 LYS A  282     PRO A  283                  145.72                    
REMARK 500 HIS A  359     HIS A  360                 -138.32                    
REMARK 500 PRO A  364     SER A  365                  141.43                    
REMARK 500 SER A  365     LEU A  366                  141.48                    
REMARK 500 ILE A  406     PRO A  407                  139.05                    
REMARK 500 VAL A  504     ASP A  505                  149.67                    
REMARK 500 LEU B  234     CYS B  235                 -143.71                    
REMARK 500 PRO B  248     CYS B  249                  149.55                    
REMARK 500 PHE B  314     ARG B  315                  137.68                    
REMARK 500 ALA B  367     ARG B  368                 -144.35                    
REMARK 500 ASP B  369     ASP B  370                 -133.71                    
REMARK 500 LEU B  476     PHE B  477                 -144.01                    
REMARK 500 PRO B  485     ARG B  486                 -146.71                    
REMARK 500 ILE B  508     GLN B  509                 -148.61                    
REMARK 500 LEU C  143     MET C  144                 -146.31                    
REMARK 500 PHE C  156     TYR C  157                  145.09                    
REMARK 500 SER C  187     GLU C  188                 -149.02                    
REMARK 500 ILE C  260     ASP C  261                 -144.35                    
REMARK 500 LYS C  374     VAL C  375                 -143.95                    
REMARK 500 ARG C  406     VAL C  407                 -136.97                    
REMARK 500 GLN C  442     ILE C  443                 -130.64                    
REMARK 500 VAL C  474     LEU C  475                 -149.60                    
REMARK 500 ASP C  538     GLN C  539                 -147.26                    
REMARK 500 GLU C  567     PHE C  568                 -144.23                    
REMARK 500 LEU C  634     PRO C  635                  143.22                    
REMARK 500 GLN C  638     ALA C  639                 -142.95                    
REMARK 500 GLU C  643     PRO C  644                 -148.41                    
REMARK 500 PHE C  649     SER C  650                 -146.55                    
REMARK 500 LEU C  655     GLN C  656                 -142.76                    
REMARK 500 SER C  657     THR C  658                 -136.84                    
REMARK 500 LEU C  669     LEU C  670                  140.19                    
REMARK 500 VAL C  708     LYS C  709                 -140.39                    
REMARK 500 PHE C  710     GLY C  711                 -143.73                    
REMARK 500 PRO C  787     TYR C  788                 -146.72                    
REMARK 500 LEU C  805     SER C  806                  125.74                    
REMARK 500 ASN C  867     LYS C  868                 -133.84                    
REMARK 500 ARG C  899     GLU C  900                  142.72                    
REMARK 500 LEU C  919     THR C  920                  146.24                    
REMARK 500 PRO C  949     GLU C  950                  146.33                    
REMARK 500 ALA C  955     PRO C  956                 -141.83                    
REMARK 500 ILE C 1013     LEU C 1014                  147.77                    
REMARK 500 GLN C 1043     ILE C 1044                 -147.22                    
REMARK 500 LYS C 1051     SER C 1052                  147.63                    
REMARK 500 GLU C 1092     GLU C 1093                  130.42                    
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     109 NON CIS, NON-TRANS OMEGA OUTLIERS.            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-6803   RELATED DB: EMDB                              
REMARK 900 CRYO-EM STRUCTURE OF HUMAN DNA-PK HOLOENZYME                         
DBREF  5Y3R A   34   534  UNP    P12956   XRCC6_HUMAN     34    534             
DBREF  5Y3R B    6   541  UNP    P13010   XRCC5_HUMAN      6    541             
DBREF  5Y3R K   11    25  PDB    5Y3R     5Y3R            11     25             
DBREF  5Y3R D  -15    18  PDB    5Y3R     5Y3R           -15     18             
DBREF  5Y3R E   16    51  PDB    5Y3R     5Y3R            16     51             
DBREF  5Y3R C   10  4128  UNP    P78527   PRKDC_HUMAN     10   4128             
SEQRES   1 A  501  GLY ARG ASP SER LEU ILE PHE LEU VAL ASP ALA SER LYS          
SEQRES   2 A  501  ALA MET PHE GLU SER GLN SER GLU ASP GLU LEU THR PRO          
SEQRES   3 A  501  PHE ASP MET SER ILE GLN CYS ILE GLN SER VAL TYR ILE          
SEQRES   4 A  501  SER LYS ILE ILE SER SER ASP ARG ASP LEU LEU ALA VAL          
SEQRES   5 A  501  VAL PHE TYR GLY THR GLU LYS ASP LYS ASN SER VAL ASN          
SEQRES   6 A  501  PHE LYS ASN ILE TYR VAL LEU GLN GLU LEU ASP ASN PRO          
SEQRES   7 A  501  GLY ALA LYS ARG ILE LEU GLU LEU ASP GLN PHE LYS GLY          
SEQRES   8 A  501  GLN GLN GLY GLN LYS ARG PHE GLN ASP MET MET GLY HIS          
SEQRES   9 A  501  GLY SER ASP TYR SER LEU SER GLU VAL LEU TRP VAL CYS          
SEQRES  10 A  501  ALA ASN LEU PHE SER ASP VAL GLN PHE LYS MET SER HIS          
SEQRES  11 A  501  LYS ARG ILE MET LEU PHE THR ASN GLU ASP ASN PRO HIS          
SEQRES  12 A  501  GLY ASN ASP SER ALA LYS ALA SER ARG ALA ARG THR LYS          
SEQRES  13 A  501  ALA GLY ASP LEU ARG ASP THR GLY ILE PHE LEU ASP LEU          
SEQRES  14 A  501  MET HIS LEU LYS LYS PRO GLY GLY PHE ASP ILE SER LEU          
SEQRES  15 A  501  PHE TYR ARG ASP ILE ILE SER ILE ALA GLU ASP GLU ASP          
SEQRES  16 A  501  LEU ARG VAL HIS PHE GLU GLU SER SER LYS LEU GLU ASP          
SEQRES  17 A  501  LEU LEU ARG LYS VAL ARG ALA LYS GLU THR ARG LYS ARG          
SEQRES  18 A  501  ALA LEU SER ARG LEU LYS LEU LYS LEU ASN LYS ASP ILE          
SEQRES  19 A  501  VAL ILE SER VAL GLY ILE TYR ASN LEU VAL GLN LYS ALA          
SEQRES  20 A  501  LEU LYS PRO PRO PRO ILE LYS LEU TYR ARG GLU THR ASN          
SEQRES  21 A  501  GLU PRO VAL LYS THR LYS THR ARG THR PHE ASN THR SER          
SEQRES  22 A  501  THR GLY GLY LEU LEU LEU PRO SER ASP THR LYS ARG SER          
SEQRES  23 A  501  GLN ILE TYR GLY SER ARG GLN ILE ILE LEU GLU LYS GLU          
SEQRES  24 A  501  GLU THR GLU GLU LEU LYS ARG PHE ASP ASP PRO GLY LEU          
SEQRES  25 A  501  MET LEU MET GLY PHE LYS PRO LEU VAL LEU LEU LYS LYS          
SEQRES  26 A  501  HIS HIS TYR LEU ARG PRO SER LEU PHE VAL TYR PRO GLU          
SEQRES  27 A  501  GLU SER LEU VAL ILE GLY SER SER THR LEU PHE SER ALA          
SEQRES  28 A  501  LEU LEU ILE LYS CYS LEU GLU LYS GLU VAL ALA ALA LEU          
SEQRES  29 A  501  CYS ARG TYR THR PRO ARG ARG ASN ILE PRO PRO TYR PHE          
SEQRES  30 A  501  VAL ALA LEU VAL PRO GLN GLU GLU GLU LEU ASP ASP GLN          
SEQRES  31 A  501  LYS ILE GLN VAL THR PRO PRO GLY PHE GLN LEU VAL PHE          
SEQRES  32 A  501  LEU PRO PHE ALA ASP ASP LYS ARG LYS MET PRO PHE THR          
SEQRES  33 A  501  GLU LYS ILE MET ALA THR PRO GLU GLN VAL GLY LYS MET          
SEQRES  34 A  501  LYS ALA ILE VAL GLU LYS LEU ARG PHE THR TYR ARG SER          
SEQRES  35 A  501  ASP SER PHE GLU ASN PRO VAL LEU GLN GLN HIS PHE ARG          
SEQRES  36 A  501  ASN LEU GLU ALA LEU ALA LEU ASP LEU MET GLU PRO GLU          
SEQRES  37 A  501  GLN ALA VAL ASP LEU THR LEU PRO LYS VAL GLU ALA MET          
SEQRES  38 A  501  ASN LYS ARG LEU GLY SER LEU VAL ASP GLU PHE LYS GLU          
SEQRES  39 A  501  LEU VAL TYR PRO PRO ASP TYR                                  
SEQRES   1 B  536  ASN LYS ALA ALA VAL VAL LEU CYS MET ASP VAL GLY PHE          
SEQRES   2 B  536  THR MET SER ASN SER ILE PRO GLY ILE GLU SER PRO PHE          
SEQRES   3 B  536  GLU GLN ALA LYS LYS VAL ILE THR MET PHE VAL GLN ARG          
SEQRES   4 B  536  GLN VAL PHE ALA GLU ASN LYS ASP GLU ILE ALA LEU VAL          
SEQRES   5 B  536  LEU PHE GLY THR ASP GLY THR ASP ASN PRO LEU SER GLY          
SEQRES   6 B  536  GLY ASP GLN TYR GLN ASN ILE THR VAL HIS ARG HIS LEU          
SEQRES   7 B  536  MET LEU PRO ASP PHE ASP LEU LEU GLU ASP ILE GLU SER          
SEQRES   8 B  536  LYS ILE GLN PRO GLY SER GLN GLN ALA ASP PHE LEU ASP          
SEQRES   9 B  536  ALA LEU ILE VAL SER MET ASP VAL ILE GLN HIS GLU THR          
SEQRES  10 B  536  ILE GLY LYS LYS PHE GLU LYS ARG HIS ILE GLU ILE PHE          
SEQRES  11 B  536  THR ASP LEU SER SER ARG PHE SER LYS SER GLN LEU ASP          
SEQRES  12 B  536  ILE ILE ILE HIS SER LEU LYS LYS CYS ASP ILE SER LEU          
SEQRES  13 B  536  GLN PHE PHE LEU PRO PHE SER LEU GLY LYS GLU ASP GLY          
SEQRES  14 B  536  SER GLY ASP ARG GLY ASP GLY PRO PHE ARG LEU GLY GLY          
SEQRES  15 B  536  HIS GLY PRO SER PHE PRO LEU LYS GLY ILE THR GLU GLN          
SEQRES  16 B  536  GLN LYS GLU GLY LEU GLU ILE VAL LYS MET VAL MET ILE          
SEQRES  17 B  536  SER LEU GLU GLY GLU ASP GLY LEU ASP GLU ILE TYR SER          
SEQRES  18 B  536  PHE SER GLU SER LEU ARG LYS LEU CYS VAL PHE LYS LYS          
SEQRES  19 B  536  ILE GLU ARG HIS SER ILE HIS TRP PRO CYS ARG LEU THR          
SEQRES  20 B  536  ILE GLY SER ASN LEU SER ILE ARG ILE ALA ALA TYR LYS          
SEQRES  21 B  536  SER ILE LEU GLN GLU ARG VAL LYS LYS THR TRP THR VAL          
SEQRES  22 B  536  VAL ASP ALA LYS THR LEU LYS LYS GLU ASP ILE GLN LYS          
SEQRES  23 B  536  GLU THR VAL TYR CYS LEU ASN ASP ASP ASP GLU THR GLU          
SEQRES  24 B  536  VAL LEU LYS GLU ASP ILE ILE GLN GLY PHE ARG TYR GLY          
SEQRES  25 B  536  SER ASP ILE VAL PRO PHE SER LYS VAL ASP GLU GLU GLN          
SEQRES  26 B  536  MET LYS TYR LYS SER GLU GLY LYS CYS PHE SER VAL LEU          
SEQRES  27 B  536  GLY PHE CYS LYS SER SER GLN VAL GLN ARG ARG PHE PHE          
SEQRES  28 B  536  MET GLY ASN GLN VAL LEU LYS VAL PHE ALA ALA ARG ASP          
SEQRES  29 B  536  ASP GLU ALA ALA ALA VAL ALA LEU SER SER LEU ILE HIS          
SEQRES  30 B  536  ALA LEU ASP ASP LEU ASP MET VAL ALA ILE VAL ARG TYR          
SEQRES  31 B  536  ALA TYR ASP LYS ARG ALA ASN PRO GLN VAL GLY VAL ALA          
SEQRES  32 B  536  PHE PRO HIS ILE LYS HIS ASN TYR GLU CYS LEU VAL TYR          
SEQRES  33 B  536  VAL GLN LEU PRO PHE MET GLU ASP LEU ARG GLN TYR MET          
SEQRES  34 B  536  PHE SER SER LEU LYS ASN SER LYS LYS TYR ALA PRO THR          
SEQRES  35 B  536  GLU ALA GLN LEU ASN ALA VAL ASP ALA LEU ILE ASP SER          
SEQRES  36 B  536  MET SER LEU ALA LYS LYS ASP GLU LYS THR ASP THR LEU          
SEQRES  37 B  536  GLU ASP LEU PHE PRO THR THR LYS ILE PRO ASN PRO ARG          
SEQRES  38 B  536  PHE GLN ARG LEU PHE GLN CYS LEU LEU HIS ARG ALA LEU          
SEQRES  39 B  536  HIS PRO ARG GLU PRO LEU PRO PRO ILE GLN GLN HIS ILE          
SEQRES  40 B  536  TRP ASN MET LEU ASN PRO PRO ALA GLU VAL THR THR LYS          
SEQRES  41 B  536  SER GLN ILE PRO LEU SER LYS ILE LYS THR LEU PHE PRO          
SEQRES  42 B  536  LEU ILE GLU                                                  
SEQRES   1 K   15  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA          
SEQRES   2 K   15  ALA ALA                                                      
SEQRES   1 D   34   DT  DA  DA  DA  DA  DA  DC  DT  DA  DT  DT  DA  DT          
SEQRES   2 D   34   DT  DA  DT  DG  DG  DT  DA  DT  DT  DA  DT  DG  DG          
SEQRES   3 D   34   DC  DC  DT  DT  DG  DG  DG  DC                              
SEQRES   1 E   36   DC  DA  DG  DC  DT  DA  DA  DT  DG  DG  DC  DC  DA          
SEQRES   2 E   36   DT  DA  DA  DT  DA  DC  DC  DA  DT  DA  DA  DT  DA          
SEQRES   3 E   36   DA  DT  DA  DG  DT  DT  DT  DT  DT  DA                      
SEQRES   1 C 4119  CYS SER LEU LEU ARG LEU GLN GLU THR LEU SER ALA ALA          
SEQRES   2 C 4119  ASP ARG CYS GLY ALA ALA LEU ALA GLY HIS GLN LEU ILE          
SEQRES   3 C 4119  ARG GLY LEU GLY GLN GLU CYS VAL LEU SER SER SER PRO          
SEQRES   4 C 4119  ALA VAL LEU ALA LEU GLN THR SER LEU VAL PHE SER ARG          
SEQRES   5 C 4119  ASP PHE GLY LEU LEU VAL PHE VAL ARG LYS SER LEU ASN          
SEQRES   6 C 4119  SER ILE GLU PHE ARG GLU CYS ARG GLU GLU ILE LEU LYS          
SEQRES   7 C 4119  PHE LEU CYS ILE PHE LEU GLU LYS MET GLY GLN LYS ILE          
SEQRES   8 C 4119  ALA PRO TYR SER VAL GLU ILE LYS ASN THR CYS THR SER          
SEQRES   9 C 4119  VAL TYR THR LYS ASP ARG ALA ALA LYS CYS LYS ILE PRO          
SEQRES  10 C 4119  ALA LEU ASP LEU LEU ILE LYS LEU LEU GLN THR PHE ARG          
SEQRES  11 C 4119  SER SER ARG LEU MET ASP GLU PHE LYS ILE GLY GLU LEU          
SEQRES  12 C 4119  PHE SER LYS PHE TYR GLY GLU LEU ALA LEU LYS LYS LYS          
SEQRES  13 C 4119  ILE PRO ASP THR VAL LEU GLU LYS VAL TYR GLU LEU LEU          
SEQRES  14 C 4119  GLY LEU LEU GLY GLU VAL HIS PRO SER GLU MET ILE ASN          
SEQRES  15 C 4119  ASN ALA GLU ASN LEU PHE ARG ALA PHE LEU GLY GLU LEU          
SEQRES  16 C 4119  LYS THR GLN MET THR SER ALA VAL ARG GLU PRO LYS LEU          
SEQRES  17 C 4119  PRO VAL LEU ALA GLY CYS LEU LYS GLY LEU SER SER LEU          
SEQRES  18 C 4119  LEU CYS ASN PHE THR LYS SER MET GLU GLU ASP PRO GLN          
SEQRES  19 C 4119  THR SER ARG GLU ILE PHE ASN PHE VAL LEU LYS ALA ILE          
SEQRES  20 C 4119  ARG PRO GLN ILE ASP LEU LYS ARG TYR ALA VAL PRO SER          
SEQRES  21 C 4119  ALA GLY LEU ARG LEU PHE ALA LEU HIS ALA SER GLN PHE          
SEQRES  22 C 4119  SER THR CYS LEU LEU ASP ASN TYR VAL SER LEU PHE GLU          
SEQRES  23 C 4119  VAL LEU LEU LYS TRP CYS ALA HIS THR ASN VAL GLU LEU          
SEQRES  24 C 4119  LYS LYS ALA ALA LEU SER ALA LEU GLU SER PHE LEU LYS          
SEQRES  25 C 4119  GLN VAL SER ASN MET VAL ALA LYS ASN ALA GLU MET HIS          
SEQRES  26 C 4119  LYS ASN LYS LEU GLN TYR PHE MET GLU GLN PHE TYR GLY          
SEQRES  27 C 4119  ILE ILE ARG ASN VAL ASP SER ASN ASN LYS GLU LEU SER          
SEQRES  28 C 4119  ILE ALA ILE ARG GLY TYR GLY LEU PHE ALA GLY PRO CYS          
SEQRES  29 C 4119  LYS VAL ILE ASN ALA LYS ASP VAL ASP PHE MET TYR VAL          
SEQRES  30 C 4119  GLU LEU ILE GLN ARG CYS LYS GLN MET PHE LEU THR GLN          
SEQRES  31 C 4119  THR ASP THR GLY ASP ASP ARG VAL TYR GLN MET PRO SER          
SEQRES  32 C 4119  PHE LEU GLN SER VAL ALA SER VAL LEU LEU TYR LEU ASP          
SEQRES  33 C 4119  THR VAL PRO GLU VAL TYR THR PRO VAL LEU GLU HIS LEU          
SEQRES  34 C 4119  VAL VAL MET GLN ILE ASP SER PHE PRO GLN TYR SER PRO          
SEQRES  35 C 4119  LYS MET GLN LEU VAL CYS CYS ARG ALA ILE VAL LYS VAL          
SEQRES  36 C 4119  PHE LEU ALA LEU ALA ALA LYS GLY PRO VAL LEU ARG ASN          
SEQRES  37 C 4119  CYS ILE SER THR VAL VAL HIS GLN GLY LEU ILE ARG ILE          
SEQRES  38 C 4119  CYS SER LYS PRO VAL VAL LEU PRO LYS GLY PRO GLU SER          
SEQRES  39 C 4119  GLU SER GLU ASP HIS ARG ALA SER GLY GLU VAL ARG THR          
SEQRES  40 C 4119  GLY LYS TRP LYS VAL PRO THR TYR LYS ASP TYR VAL ASP          
SEQRES  41 C 4119  LEU PHE ARG HIS LEU LEU SER SER ASP GLN MET MET ASP          
SEQRES  42 C 4119  SER ILE LEU ALA ASP GLU ALA PHE PHE SER VAL ASN SER          
SEQRES  43 C 4119  SER SER GLU SER LEU ASN HIS LEU LEU TYR ASP GLU PHE          
SEQRES  44 C 4119  VAL LYS SER VAL LEU LYS ILE VAL GLU LYS LEU ASP LEU          
SEQRES  45 C 4119  THR LEU GLU ILE GLN THR VAL GLY GLU GLN GLU ASN GLY          
SEQRES  46 C 4119  ASP GLU ALA PRO GLY VAL TRP MET ILE PRO THR SER ASP          
SEQRES  47 C 4119  PRO ALA ALA ASN LEU HIS PRO ALA LYS PRO LYS ASP PHE          
SEQRES  48 C 4119  SER ALA PHE ILE ASN LEU VAL GLU PHE CYS ARG GLU ILE          
SEQRES  49 C 4119  LEU PRO GLU LYS GLN ALA GLU PHE PHE GLU PRO TRP VAL          
SEQRES  50 C 4119  TYR SER PHE SER TYR GLU LEU ILE LEU GLN SER THR ARG          
SEQRES  51 C 4119  LEU PRO LEU ILE SER GLY PHE TYR LYS LEU LEU SER ILE          
SEQRES  52 C 4119  THR VAL ARG ASN ALA LYS LYS ILE LYS TYR PHE GLU GLY          
SEQRES  53 C 4119  VAL SER PRO LYS SER LEU LYS HIS SER PRO GLU ASP PRO          
SEQRES  54 C 4119  GLU LYS TYR SER CYS PHE ALA LEU PHE VAL LYS PHE GLY          
SEQRES  55 C 4119  LYS GLU VAL ALA VAL LYS MET LYS GLN TYR LYS ASP GLU          
SEQRES  56 C 4119  LEU LEU ALA SER CYS LEU THR PHE LEU LEU SER LEU PRO          
SEQRES  57 C 4119  HIS ASN ILE ILE GLU LEU ASP VAL ARG ALA TYR VAL PRO          
SEQRES  58 C 4119  ALA LEU GLN MET ALA PHE LYS LEU GLY LEU SER TYR THR          
SEQRES  59 C 4119  PRO LEU ALA GLU VAL GLY LEU ASN ALA LEU GLU GLU TRP          
SEQRES  60 C 4119  SER ILE TYR ILE ASP ARG HIS VAL MET GLN PRO TYR TYR          
SEQRES  61 C 4119  LYS ASP ILE LEU PRO CYS LEU ASP GLY TYR LEU LYS THR          
SEQRES  62 C 4119  SER ALA LEU SER ASP GLU THR LYS ASN ASN TRP GLU VAL          
SEQRES  63 C 4119  SER ALA LEU SER ARG ALA ALA GLN LYS GLY PHE ASN LYS          
SEQRES  64 C 4119  VAL VAL LEU LYS HIS LEU LYS LYS THR LYS ASN LEU SER          
SEQRES  65 C 4119  SER ASN GLU ALA ILE SER LEU GLU GLU ILE ARG ILE ARG          
SEQRES  66 C 4119  VAL VAL GLN MET LEU GLY SER LEU GLY GLY GLN ILE ASN          
SEQRES  67 C 4119  LYS ASN LEU LEU THR VAL THR SER SER ASP GLU MET MET          
SEQRES  68 C 4119  LYS SER TYR VAL ALA TRP ASP ARG GLU LYS ARG LEU SER          
SEQRES  69 C 4119  PHE ALA VAL PRO PHE ARG GLU MET LYS PRO VAL ILE PHE          
SEQRES  70 C 4119  LEU ASP VAL PHE LEU PRO ARG VAL THR GLU LEU ALA LEU          
SEQRES  71 C 4119  THR ALA SER ASP ARG GLN THR LYS VAL ALA ALA CYS GLU          
SEQRES  72 C 4119  LEU LEU HIS SER MET VAL MET PHE MET LEU GLY LYS ALA          
SEQRES  73 C 4119  THR GLN MET PRO GLU GLY GLY GLN GLY ALA PRO PRO MET          
SEQRES  74 C 4119  TYR GLN LEU TYR LYS ARG THR PHE PRO VAL LEU LEU ARG          
SEQRES  75 C 4119  LEU ALA CYS ASP VAL ASP GLN VAL THR ARG GLN LEU TYR          
SEQRES  76 C 4119  GLU PRO LEU VAL MET GLN LEU ILE HIS TRP PHE THR ASN          
SEQRES  77 C 4119  ASN LYS LYS PHE GLU SER GLN ASP THR VAL ALA LEU LEU          
SEQRES  78 C 4119  GLU ALA ILE LEU ASP GLY ILE VAL ASP PRO VAL ASP SER          
SEQRES  79 C 4119  THR LEU ARG ASP PHE CYS GLY ARG CYS ILE ARG GLU PHE          
SEQRES  80 C 4119  LEU LYS TRP SER ILE LYS GLN ILE THR PRO GLN GLN GLN          
SEQRES  81 C 4119  GLU LYS SER PRO VAL ASN THR LYS SER LEU PHE LYS ARG          
SEQRES  82 C 4119  LEU TYR SER LEU ALA LEU HIS PRO ASN ALA PHE LYS ARG          
SEQRES  83 C 4119  LEU GLY ALA SER LEU ALA PHE ASN ASN ILE TYR ARG GLU          
SEQRES  84 C 4119  PHE ARG GLU GLU GLU SER LEU VAL GLU GLN PHE VAL PHE          
SEQRES  85 C 4119  GLU ALA LEU VAL ILE TYR MET GLU SER LEU ALA LEU ALA          
SEQRES  86 C 4119  HIS ALA ASP GLU LYS SER LEU GLY THR ILE GLN GLN CYS          
SEQRES  87 C 4119  CYS ASP ALA ILE ASP HIS LEU CYS ARG ILE ILE GLU LYS          
SEQRES  88 C 4119  LYS HIS VAL SER LEU ASN LYS ALA LYS LYS ARG ARG LEU          
SEQRES  89 C 4119  PRO ARG GLY PHE PRO PRO SER ALA SER LEU CYS LEU LEU          
SEQRES  90 C 4119  ASP LEU VAL LYS TRP LEU LEU ALA HIS CYS GLY ARG PRO          
SEQRES  91 C 4119  GLN THR GLU CYS ARG HIS LYS SER ILE GLU LEU PHE TYR          
SEQRES  92 C 4119  LYS PHE VAL PRO LEU LEU PRO GLY ASN ARG SER PRO ASN          
SEQRES  93 C 4119  LEU TRP LEU LYS ASP VAL LEU LYS GLU GLU GLY VAL SER          
SEQRES  94 C 4119  PHE LEU ILE ASN THR PHE GLU GLY GLY GLY CYS GLY GLN          
SEQRES  95 C 4119  PRO SER GLY ILE LEU ALA GLN PRO THR LEU LEU TYR LEU          
SEQRES  96 C 4119  ARG GLY PRO PHE SER LEU GLN ALA THR LEU CYS TRP LEU          
SEQRES  97 C 4119  ASP LEU LEU LEU ALA ALA LEU GLU CYS TYR ASN THR PHE          
SEQRES  98 C 4119  ILE GLY GLU ARG THR VAL GLY ALA LEU GLN VAL LEU GLY          
SEQRES  99 C 4119  THR GLU ALA GLN SER SER LEU LEU LYS ALA VAL ALA PHE          
SEQRES 100 C 4119  PHE LEU GLU SER ILE ALA MET HIS ASP ILE ILE ALA ALA          
SEQRES 101 C 4119  GLU LYS CYS PHE GLY THR GLY ALA ALA GLY ASN ARG THR          
SEQRES 102 C 4119  SER PRO GLN GLU GLY GLU ARG TYR ASN TYR SER LYS CYS          
SEQRES 103 C 4119  THR VAL VAL VAL ARG ILE MET GLU PHE THR THR THR LEU          
SEQRES 104 C 4119  LEU ASN THR SER PRO GLU GLY TRP LYS LEU LEU LYS LYS          
SEQRES 105 C 4119  ASP LEU CYS ASN THR HIS LEU MET ARG VAL LEU VAL GLN          
SEQRES 106 C 4119  THR LEU CYS GLU PRO ALA SER ILE GLY PHE ASN ILE GLY          
SEQRES 107 C 4119  ASP VAL GLN VAL MET ALA HIS LEU PRO ASP VAL CYS VAL          
SEQRES 108 C 4119  ASN LEU MET LYS ALA LEU LYS MET SER PRO TYR LYS ASP          
SEQRES 109 C 4119  ILE LEU GLU THR HIS LEU ARG GLU LYS ILE THR ALA GLN          
SEQRES 110 C 4119  SER ILE GLU GLU LEU CYS ALA VAL ASN LEU TYR GLY PRO          
SEQRES 111 C 4119  ASP ALA GLN VAL ASP ARG SER ARG LEU ALA ALA VAL VAL          
SEQRES 112 C 4119  SER ALA CYS LYS GLN LEU HIS ARG ALA GLY LEU LEU HIS          
SEQRES 113 C 4119  ASN ILE LEU PRO SER GLN SER THR ASP LEU HIS HIS SER          
SEQRES 114 C 4119  VAL GLY THR GLU LEU LEU SER LEU VAL TYR LYS GLY ILE          
SEQRES 115 C 4119  ALA PRO GLY ASP GLU ARG GLN CYS LEU PRO SER LEU ASP          
SEQRES 116 C 4119  LEU SER CYS LYS GLN LEU ALA SER GLY LEU LEU GLU LEU          
SEQRES 117 C 4119  ALA PHE ALA PHE GLY GLY LEU CYS GLU ARG LEU VAL SER          
SEQRES 118 C 4119  LEU LEU LEU ASN PRO ALA VAL LEU SER THR ALA SER LEU          
SEQRES 119 C 4119  GLY SER SER GLN GLY SER VAL ILE HIS PHE SER HIS GLY          
SEQRES 120 C 4119  GLU TYR PHE TYR SER LEU PHE SER GLU THR ILE ASN THR          
SEQRES 121 C 4119  GLU LEU LEU LYS ASN LEU ASP LEU ALA VAL LEU GLU LEU          
SEQRES 122 C 4119  MET GLN SER SER VAL ASP ASN THR LYS MET VAL SER ALA          
SEQRES 123 C 4119  VAL LEU ASN GLY MET LEU ASP GLN SER PHE ARG GLU ARG          
SEQRES 124 C 4119  ALA ASN GLN LYS HIS GLN GLY LEU LYS LEU ALA THR THR          
SEQRES 125 C 4119  ILE LEU GLN HIS TRP LYS LYS CYS ASP SER TRP TRP ALA          
SEQRES 126 C 4119  LYS ASP SER PRO LEU GLU THR LYS MET ALA VAL LEU ALA          
SEQRES 127 C 4119  LEU LEU ALA LYS ILE LEU GLN ILE ASP SER SER VAL SER          
SEQRES 128 C 4119  PHE ASN THR SER HIS GLY SER PHE PRO GLU VAL PHE THR          
SEQRES 129 C 4119  THR TYR ILE SER LEU LEU ALA ASP THR LYS LEU ASP LEU          
SEQRES 130 C 4119  HIS LEU LYS GLY GLN ALA VAL THR LEU LEU PRO PHE PHE          
SEQRES 131 C 4119  THR SER LEU THR GLY GLY SER LEU GLU GLU LEU ARG ARG          
SEQRES 132 C 4119  VAL LEU GLU GLN LEU ILE VAL ALA HIS PHE PRO MET GLN          
SEQRES 133 C 4119  SER ARG GLU PHE PRO PRO GLY THR PRO ARG PHE ASN ASN          
SEQRES 134 C 4119  TYR VAL ASP CYS MET LYS LYS PHE LEU ASP ALA LEU GLU          
SEQRES 135 C 4119  LEU SER GLN SER PRO MET LEU LEU GLU LEU MET THR GLU          
SEQRES 136 C 4119  VAL LEU CYS ARG GLU GLN GLN HIS VAL MET GLU GLU LEU          
SEQRES 137 C 4119  PHE GLN SER SER PHE ARG ARG ILE ALA ARG ARG GLY SER          
SEQRES 138 C 4119  CYS VAL THR GLN VAL GLY LEU LEU GLU SER VAL TYR GLU          
SEQRES 139 C 4119  MET PHE ARG LYS ASP ASP PRO ARG LEU SER PHE THR ARG          
SEQRES 140 C 4119  GLN SER PHE VAL ASP ARG SER LEU LEU THR LEU LEU TRP          
SEQRES 141 C 4119  HIS CYS SER LEU ASP ALA LEU ARG GLU PHE PHE SER THR          
SEQRES 142 C 4119  ILE VAL VAL ASP ALA ILE ASP VAL LEU LYS SER ARG PHE          
SEQRES 143 C 4119  THR LYS LEU ASN GLU SER THR PHE ASP THR GLN ILE THR          
SEQRES 144 C 4119  LYS LYS MET GLY TYR TYR LYS ILE LEU ASP VAL MET TYR          
SEQRES 145 C 4119  SER ARG LEU PRO LYS ASP ASP VAL HIS ALA LYS GLU SER          
SEQRES 146 C 4119  LYS ILE ASN GLN VAL PHE HIS GLY SER CYS ILE THR GLU          
SEQRES 147 C 4119  GLY ASN GLU LEU THR LYS THR LEU ILE LYS LEU CYS TYR          
SEQRES 148 C 4119  ASP ALA PHE THR GLU ASN MET ALA GLY GLU ASN GLN LEU          
SEQRES 149 C 4119  LEU GLU ARG ARG ARG LEU TYR HIS CYS ALA ALA TYR ASN          
SEQRES 150 C 4119  CYS ALA ILE SER VAL ILE CYS CYS VAL PHE ASN GLU LEU          
SEQRES 151 C 4119  LYS PHE TYR GLN GLY PHE LEU PHE SER GLU LYS PRO GLU          
SEQRES 152 C 4119  LYS ASN LEU LEU ILE PHE GLU ASN LEU ILE ASP LEU LYS          
SEQRES 153 C 4119  ARG ARG TYR ASN PHE PRO VAL GLU VAL GLU VAL PRO MET          
SEQRES 154 C 4119  GLU ARG LYS LYS LYS TYR ILE GLU ILE ARG LYS GLU ALA          
SEQRES 155 C 4119  ARG GLU ALA ALA ASN GLY ASP SER ASP GLY PRO SER TYR          
SEQRES 156 C 4119  MET SER SER LEU SER TYR LEU ALA ASP SER THR LEU SER          
SEQRES 157 C 4119  GLU GLU MET SER GLN PHE ASP PHE SER THR GLY VAL GLN          
SEQRES 158 C 4119  SER TYR SER TYR SER SER GLN ASP PRO ARG PRO ALA THR          
SEQRES 159 C 4119  GLY ARG PHE ARG ARG ARG GLU GLN ARG ASP PRO THR VAL          
SEQRES 160 C 4119  HIS ASP ASP VAL LEU GLU LEU GLU MET ASP GLU LEU ASN          
SEQRES 161 C 4119  ARG HIS GLU CYS MET ALA PRO LEU THR ALA LEU VAL LYS          
SEQRES 162 C 4119  HIS MET HIS ARG SER LEU GLY PRO PRO GLN GLY GLU GLU          
SEQRES 163 C 4119  ASP SER VAL PRO ARG ASP LEU PRO SER TRP MET LYS PHE          
SEQRES 164 C 4119  LEU HIS GLY LYS LEU GLY ASN PRO ILE VAL PRO LEU ASN          
SEQRES 165 C 4119  ILE ARG LEU PHE LEU ALA LYS LEU VAL ILE ASN THR GLU          
SEQRES 166 C 4119  GLU VAL PHE ARG PRO TYR ALA LYS HIS TRP LEU SER PRO          
SEQRES 167 C 4119  LEU LEU GLN LEU ALA ALA SER GLU ASN ASN GLY GLY GLU          
SEQRES 168 C 4119  GLY ILE HIS TYR MET VAL VAL GLU ILE VAL ALA THR ILE          
SEQRES 169 C 4119  LEU SER TRP THR GLY LEU ALA THR PRO THR GLY VAL PRO          
SEQRES 170 C 4119  LYS ASP GLU VAL LEU ALA ASN ARG LEU LEU ASN PHE LEU          
SEQRES 171 C 4119  MET LYS HIS VAL PHE HIS PRO LYS ARG ALA VAL PHE ARG          
SEQRES 172 C 4119  HIS ASN LEU GLU ILE ILE LYS THR LEU VAL GLU CYS TRP          
SEQRES 173 C 4119  LYS ASP CYS LEU SER ILE PRO TYR ARG LEU ILE PHE GLU          
SEQRES 174 C 4119  LYS PHE SER GLY LYS ASP PRO ASN SER LYS ASP ASN SER          
SEQRES 175 C 4119  VAL GLY ILE GLN LEU LEU GLY ILE VAL MET ALA ASN ASP          
SEQRES 176 C 4119  LEU PRO PRO TYR ASP PRO GLN CYS GLY ILE GLN SER SER          
SEQRES 177 C 4119  GLU TYR PHE GLN ALA LEU VAL ASN ASN MET SER PHE VAL          
SEQRES 178 C 4119  ARG TYR LYS GLU VAL TYR ALA ALA ALA ALA GLU VAL LEU          
SEQRES 179 C 4119  GLY LEU ILE LEU ARG TYR VAL MET GLU ARG LYS ASN ILE          
SEQRES 180 C 4119  LEU GLU GLU SER LEU CYS GLU LEU VAL ALA LYS GLN LEU          
SEQRES 181 C 4119  LYS GLN HIS GLN ASN THR MET GLU ASP LYS PHE ILE VAL          
SEQRES 182 C 4119  CYS LEU ASN LYS VAL THR LYS SER PHE PRO PRO LEU ALA          
SEQRES 183 C 4119  ASP ARG PHE MET ASN ALA VAL PHE PHE LEU LEU PRO LYS          
SEQRES 184 C 4119  PHE HIS GLY VAL LEU LYS THR LEU CYS LEU GLU VAL VAL          
SEQRES 185 C 4119  LEU CYS ARG VAL GLU GLY MET THR GLU LEU TYR PHE GLN          
SEQRES 186 C 4119  LEU LYS SER LYS ASP PHE VAL GLN VAL MET ARG HIS ARG          
SEQRES 187 C 4119  ASP ASP GLU ARG GLN LYS VAL CYS LEU ASP ILE ILE TYR          
SEQRES 188 C 4119  LYS MET MET PRO LYS LEU LYS PRO VAL GLU LEU ARG GLU          
SEQRES 189 C 4119  LEU LEU ASN PRO VAL VAL GLU PHE VAL SER HIS PRO SER          
SEQRES 190 C 4119  THR THR CYS ARG GLU GLN MET TYR ASN ILE LEU MET TRP          
SEQRES 191 C 4119  ILE HIS ASP ASN TYR ARG ASP PRO GLU SER GLU THR ASP          
SEQRES 192 C 4119  ASN ASP SER GLN GLU ILE PHE LYS LEU ALA LYS ASP VAL          
SEQRES 193 C 4119  LEU ILE GLN GLY LEU ILE ASP GLU ASN PRO GLY LEU GLN          
SEQRES 194 C 4119  LEU ILE ILE ARG ASN PHE TRP SER HIS GLU THR ARG LEU          
SEQRES 195 C 4119  PRO SER ASN THR LEU ASP ARG LEU LEU ALA LEU ASN SER          
SEQRES 196 C 4119  LEU TYR SER PRO LYS ILE GLU VAL HIS PHE LEU SER LEU          
SEQRES 197 C 4119  ALA THR ASN PHE LEU LEU GLU MET THR SER MET SER PRO          
SEQRES 198 C 4119  ASP TYR PRO ASN PRO MET PHE GLU HIS PRO LEU SER GLU          
SEQRES 199 C 4119  CYS GLU PHE GLN GLU TYR THR ILE ASP SER ASP TRP ARG          
SEQRES 200 C 4119  PHE ARG SER THR VAL LEU THR PRO MET PHE VAL GLU THR          
SEQRES 201 C 4119  GLN ALA SER GLN GLY THR LEU GLN THR ARG THR GLN GLU          
SEQRES 202 C 4119  GLY SER LEU SER ALA ARG TRP PRO VAL ALA GLY GLN ILE          
SEQRES 203 C 4119  ARG ALA THR GLN GLN GLN HIS ASP PHE THR LEU THR GLN          
SEQRES 204 C 4119  THR ALA ASP GLY ARG SER SER PHE ASP TRP LEU THR GLY          
SEQRES 205 C 4119  SER SER THR ASP PRO LEU VAL ASP HIS THR SER PRO SER          
SEQRES 206 C 4119  SER ASP SER LEU LEU PHE ALA HIS LYS ARG SER GLU ARG          
SEQRES 207 C 4119  LEU GLN ARG ALA PRO LEU LYS SER VAL GLY PRO ASP PHE          
SEQRES 208 C 4119  GLY LYS LYS ARG LEU GLY LEU PRO GLY ASP GLU VAL ASP          
SEQRES 209 C 4119  ASN LYS VAL LYS GLY ALA ALA GLY ARG THR ASP LEU LEU          
SEQRES 210 C 4119  ARG LEU ARG ARG ARG PHE MET ARG ASP GLN GLU LYS LEU          
SEQRES 211 C 4119  SER LEU MET TYR ALA ARG LYS GLY VAL ALA GLU GLN LYS          
SEQRES 212 C 4119  ARG GLU LYS GLU ILE LYS SER GLU LEU LYS MET LYS GLN          
SEQRES 213 C 4119  ASP ALA GLN VAL VAL LEU TYR ARG SER TYR ARG HIS GLY          
SEQRES 214 C 4119  ASP LEU PRO ASP ILE GLN ILE LYS HIS SER SER LEU ILE          
SEQRES 215 C 4119  THR PRO LEU GLN ALA VAL ALA GLN ARG ASP PRO ILE ILE          
SEQRES 216 C 4119  ALA LYS GLN LEU PHE SER SER LEU PHE SER GLY ILE LEU          
SEQRES 217 C 4119  LYS GLU MET ASP LYS PHE LYS THR LEU SER GLU LYS ASN          
SEQRES 218 C 4119  ASN ILE THR GLN LYS LEU LEU GLN ASP PHE ASN ARG PHE          
SEQRES 219 C 4119  LEU ASN THR THR PHE SER PHE PHE PRO PRO PHE VAL SER          
SEQRES 220 C 4119  CYS ILE GLN ASP ILE SER CYS GLN HIS ALA ALA LEU LEU          
SEQRES 221 C 4119  SER LEU ASP PRO ALA ALA VAL SER ALA GLY CYS LEU ALA          
SEQRES 222 C 4119  SER LEU GLN GLN PRO VAL GLY ILE ARG LEU LEU GLU GLU          
SEQRES 223 C 4119  ALA LEU LEU ARG LEU LEU PRO ALA GLU LEU PRO ALA LYS          
SEQRES 224 C 4119  ARG VAL ARG GLY LYS ALA ARG LEU PRO PRO ASP VAL LEU          
SEQRES 225 C 4119  ARG TRP VAL GLU LEU ALA LYS LEU TYR ARG SER ILE GLY          
SEQRES 226 C 4119  GLU TYR ASP VAL LEU ARG GLY ILE PHE THR SER GLU ILE          
SEQRES 227 C 4119  GLY THR LYS GLN ILE THR GLN SER ALA LEU LEU ALA GLU          
SEQRES 228 C 4119  ALA ARG SER ASP TYR SER GLU ALA ALA LYS GLN TYR ASP          
SEQRES 229 C 4119  GLU ALA LEU ASN LYS GLN ASP TRP VAL ASP GLY GLU PRO          
SEQRES 230 C 4119  THR GLU ALA GLU LYS ASP PHE TRP GLU LEU ALA SER LEU          
SEQRES 231 C 4119  ASP CYS TYR ASN HIS LEU ALA GLU TRP LYS SER LEU GLU          
SEQRES 232 C 4119  TYR CYS SER THR ALA SER ILE ASP SER GLU ASN PRO PRO          
SEQRES 233 C 4119  ASP LEU ASN LYS ILE TRP SER GLU PRO PHE TYR GLN GLU          
SEQRES 234 C 4119  THR TYR LEU PRO TYR MET ILE ARG SER LYS LEU LYS LEU          
SEQRES 235 C 4119  LEU LEU GLN GLY GLU ALA ASP GLN SER LEU LEU THR PHE          
SEQRES 236 C 4119  ILE ASP LYS ALA MET HIS GLY GLU LEU GLN LYS ALA ILE          
SEQRES 237 C 4119  LEU GLU LEU HIS TYR SER GLN GLU LEU SER LEU LEU TYR          
SEQRES 238 C 4119  LEU LEU GLN ASP ASP VAL ASP ARG ALA LYS TYR TYR ILE          
SEQRES 239 C 4119  GLN ASN GLY ILE GLN SER PHE MET GLN ASN TYR SER SER          
SEQRES 240 C 4119  ILE ASP VAL LEU LEU HIS GLN SER ARG LEU THR LYS LEU          
SEQRES 241 C 4119  GLN SER VAL GLN ALA LEU THR GLU ILE GLN GLU PHE ILE          
SEQRES 242 C 4119  SER PHE ILE SER LYS GLN GLY ASN LEU SER SER GLN VAL          
SEQRES 243 C 4119  PRO LEU LYS ARG LEU LEU ASN THR TRP THR ASN ARG TYR          
SEQRES 244 C 4119  PRO ASP ALA LYS MET ASP PRO MET ASN ILE TRP ASP ASP          
SEQRES 245 C 4119  ILE ILE THR ASN ARG CYS PHE PHE LEU SER LYS ILE GLU          
SEQRES 246 C 4119  GLU LYS LEU THR PRO LEU PRO GLU ASP ASN SER MET ASN          
SEQRES 247 C 4119  VAL ASP GLN ASP GLY ASP PRO SER ASP ARG MET GLU VAL          
SEQRES 248 C 4119  GLN GLU GLN GLU GLU ASP ILE SER SER LEU ILE ARG SER          
SEQRES 249 C 4119  CYS LYS PHE SER MET LYS MET LYS MET ILE ASP SER ALA          
SEQRES 250 C 4119  ARG LYS GLN ASN ASN PHE SER LEU ALA MET LYS LEU LEU          
SEQRES 251 C 4119  LYS GLU LEU HIS LYS GLU SER LYS THR ARG ASP ASP TRP          
SEQRES 252 C 4119  LEU VAL SER TRP VAL GLN SER TYR CYS ARG LEU SER HIS          
SEQRES 253 C 4119  CYS ARG SER ARG SER GLN GLY CYS SER GLU GLN VAL LEU          
SEQRES 254 C 4119  THR VAL LEU LYS THR VAL SER LEU LEU ASP GLU ASN ASN          
SEQRES 255 C 4119  VAL SER SER TYR LEU SER LYS ASN ILE LEU ALA PHE ARG          
SEQRES 256 C 4119  ASP GLN ASN ILE LEU LEU GLY THR THR TYR ARG ILE ILE          
SEQRES 257 C 4119  ALA ASN ALA LEU SER SER GLU PRO ALA CYS LEU ALA GLU          
SEQRES 258 C 4119  ILE GLU GLU ASP LYS ALA ARG ARG ILE LEU GLU LEU SER          
SEQRES 259 C 4119  GLY SER SER SER GLU ASP SER GLU LYS VAL ILE ALA GLY          
SEQRES 260 C 4119  LEU TYR GLN ARG ALA PHE GLN HIS LEU SER GLU ALA VAL          
SEQRES 261 C 4119  GLN ALA ALA GLU GLU GLU ALA GLN PRO PRO SER TRP SER          
SEQRES 262 C 4119  CYS GLY PRO ALA ALA GLY VAL ILE ASP ALA TYR MET THR          
SEQRES 263 C 4119  LEU ALA ASP PHE CYS ASP GLN GLN LEU ARG LYS GLU GLU          
SEQRES 264 C 4119  GLU ASN ALA SER VAL ILE ASP SER ALA GLU LEU GLN ALA          
SEQRES 265 C 4119  TYR PRO ALA LEU VAL VAL GLU LYS MET LEU LYS ALA LEU          
SEQRES 266 C 4119  LYS LEU ASN SER ASN GLU ALA ARG LEU LYS PHE PRO ARG          
SEQRES 267 C 4119  LEU LEU GLN ILE ILE GLU ARG TYR PRO GLU GLU THR LEU          
SEQRES 268 C 4119  SER LEU MET THR LYS GLU ILE SER SER VAL PRO CYS TRP          
SEQRES 269 C 4119  GLN PHE ILE SER TRP ILE SER HIS MET VAL ALA LEU LEU          
SEQRES 270 C 4119  ASP LYS ASP GLN ALA VAL ALA VAL GLN HIS SER VAL GLU          
SEQRES 271 C 4119  GLU ILE THR ASP ASN TYR PRO GLN ALA ILE VAL TYR PRO          
SEQRES 272 C 4119  PHE ILE ILE SER SER GLU SER TYR SER PHE LYS ASP THR          
SEQRES 273 C 4119  SER THR GLY HIS LYS ASN LYS GLU PHE VAL ALA ARG ILE          
SEQRES 274 C 4119  LYS SER LYS LEU ASP GLN GLY GLY VAL ILE GLN ASP PHE          
SEQRES 275 C 4119  ILE ASN ALA LEU ASP GLN LEU SER ASN PRO GLU LEU LEU          
SEQRES 276 C 4119  PHE LYS ASP TRP SER ASN ASP VAL ARG ALA GLU LEU ALA          
SEQRES 277 C 4119  LYS THR PRO VAL ASN LYS LYS ASN ILE GLU LYS MET TYR          
SEQRES 278 C 4119  GLU ARG MET TYR ALA ALA LEU GLY ASP PRO LYS ALA PRO          
SEQRES 279 C 4119  GLY LEU GLY ALA PHE ARG ARG LYS PHE ILE GLN THR PHE          
SEQRES 280 C 4119  GLY LYS GLU PHE ASP LYS HIS PHE GLY LYS GLY GLY SER          
SEQRES 281 C 4119  LYS LEU LEU ARG MET LYS LEU SER ASP PHE ASN ASP ILE          
SEQRES 282 C 4119  THR ASN MET LEU LEU LEU LYS MET ASN LYS ASP SER LYS          
SEQRES 283 C 4119  PRO PRO GLY ASN LEU LYS GLU CYS SER PRO TRP MET SER          
SEQRES 284 C 4119  ASP PHE LYS VAL GLU PHE LEU ARG ASN GLU LEU GLU ILE          
SEQRES 285 C 4119  PRO GLY GLN TYR ASP GLY ARG GLY LYS PRO LEU PRO GLU          
SEQRES 286 C 4119  TYR HIS VAL ARG ILE ALA GLY PHE ASP GLU ARG VAL THR          
SEQRES 287 C 4119  VAL MET ALA SER LEU ARG ARG PRO LYS ARG ILE ILE ILE          
SEQRES 288 C 4119  ARG GLY HIS ASP GLU ARG GLU HIS PRO PHE LEU VAL LYS          
SEQRES 289 C 4119  GLY GLY GLU ASP LEU ARG GLN ASP GLN ARG VAL GLU GLN          
SEQRES 290 C 4119  LEU PHE GLN VAL MET ASN GLY ILE LEU ALA GLN ASP SER          
SEQRES 291 C 4119  ALA CYS SER GLN ARG ALA LEU GLN LEU ARG THR TYR SER          
SEQRES 292 C 4119  VAL VAL PRO MET THR SER ARG LEU GLY LEU ILE GLU TRP          
SEQRES 293 C 4119  LEU GLU ASN THR VAL THR LEU LYS ASP LEU LEU LEU ASN          
SEQRES 294 C 4119  THR MET SER GLN GLU GLU LYS ALA ALA TYR LEU SER ASP          
SEQRES 295 C 4119  PRO ARG ALA PRO PRO CYS GLU TYR LYS ASP TRP LEU THR          
SEQRES 296 C 4119  LYS MET SER GLY LYS HIS ASP VAL GLY ALA TYR MET LEU          
SEQRES 297 C 4119  MET TYR LYS GLY ALA ASN ARG THR GLU THR VAL THR SER          
SEQRES 298 C 4119  PHE ARG LYS ARG GLU SER LYS VAL PRO ALA ASP LEU LEU          
SEQRES 299 C 4119  LYS ARG ALA PHE VAL ARG MET SER THR SER PRO GLU ALA          
SEQRES 300 C 4119  PHE LEU ALA LEU ARG SER HIS PHE ALA SER SER HIS ALA          
SEQRES 301 C 4119  LEU ILE CYS ILE SER HIS TRP ILE LEU GLY ILE GLY ASP          
SEQRES 302 C 4119  ARG HIS LEU ASN ASN PHE MET VAL ALA MET GLU THR GLY          
SEQRES 303 C 4119  GLY VAL ILE GLY ILE ASP PHE GLY HIS ALA PHE GLY SER          
SEQRES 304 C 4119  ALA THR GLN PHE LEU PRO VAL PRO GLU LEU MET PRO PHE          
SEQRES 305 C 4119  ARG LEU THR ARG GLN PHE ILE ASN LEU MET LEU PRO MET          
SEQRES 306 C 4119  LYS GLU THR GLY LEU MET TYR SER ILE MET VAL HIS ALA          
SEQRES 307 C 4119  LEU ARG ALA PHE ARG SER ASP PRO GLY LEU LEU THR ASN          
SEQRES 308 C 4119  THR MET ASP VAL PHE VAL LYS GLU PRO SER PHE ASP TRP          
SEQRES 309 C 4119  LYS ASN PHE GLU GLN LYS MET LEU LYS LYS GLY GLY SER          
SEQRES 310 C 4119  TRP ILE GLN GLU ILE ASN VAL ALA GLU LYS ASN TRP TYR          
SEQRES 311 C 4119  PRO ARG GLN LYS ILE CYS TYR ALA LYS ARG LYS LEU ALA          
SEQRES 312 C 4119  GLY ALA ASN PRO ALA VAL ILE THR CYS ASP GLU LEU LEU          
SEQRES 313 C 4119  LEU GLY HIS GLU LYS ALA PRO ALA PHE ARG ASP TYR VAL          
SEQRES 314 C 4119  ALA VAL ALA ARG GLY SER LYS ASP HIS ASN ILE ARG ALA          
SEQRES 315 C 4119  GLN GLU PRO GLU SER GLY LEU SER GLU GLU THR GLN VAL          
SEQRES 316 C 4119  LYS CYS LEU MET ASP GLN ALA THR ASP PRO ASN ILE LEU          
SEQRES 317 C 4119  GLY ARG THR TRP GLU GLY TRP GLU PRO TRP MET                  
HELIX    1 AA1 THR A   58  SER A   77  1                                  20    
HELIX    2 AA2 GLY A  112  ASP A  120  1                                   9    
HELIX    3 AA3 GLN A  121  LYS A  123  5                                   3    
HELIX    4 AA4 GLY A  124  GLY A  136  1                                  13    
HELIX    5 AA5 SER A  142  SER A  155  1                                  14    
HELIX    6 AA6 ASP A  179  THR A  196  1                                  18    
HELIX    7 AA7 LYS A  207  PHE A  211  5                                   5    
HELIX    8 AA8 LEU A  239  ALA A  248  1                                  10    
HELIX    9 AA9 GLU A  330  LYS A  338  1                                   9    
HELIX   10 AB1 VAL A  354  LEU A  356  5                                   3    
HELIX   11 AB2 SER A  379  LYS A  392  1                                  14    
HELIX   12 AB3 PHE A  439  ARG A  444  1                                   6    
HELIX   13 AB4 THR A  455  ARG A  470  1                                  16    
HELIX   14 AB5 ASN A  480  ASP A  496  1                                  17    
HELIX   15 AB6 LYS A  510  LEU A  518  1                                   9    
HELIX   16 AB7 LEU A  521  TYR A  530  1                                  10    
HELIX   17 AB8 SER B   29  PHE B   47  1                                  19    
HELIX   18 AB9 ASP B   87  ILE B   98  1                                  12    
HELIX   19 AC1 ASP B  106  ILE B  123  1                                  18    
HELIX   20 AC2 GLN B  146  CYS B  157  1                                  12    
HELIX   21 AC3 PRO B  193  THR B  198  5                                   6    
HELIX   22 AC4 GLU B  199  GLU B  216  1                                  18    
HELIX   23 AC5 GLY B  217  ASP B  222  5                                   6    
HELIX   24 AC6 SER B  228  LYS B  233  1                                   6    
HELIX   25 AC7 LEU B  234  LYS B  238  5                                   5    
HELIX   26 AC8 LYS B  285  ILE B  289  5                                   5    
HELIX   27 AC9 LYS B  325  LYS B  332  1                                   8    
HELIX   28 AD1 GLU B  371  ASP B  386  1                                  16    
HELIX   29 AD2 PHE B  426  LEU B  430  5                                   5    
HELIX   30 AD3 THR B  447  MET B  461  1                                  15    
HELIX   31 AD4 ASN B  484  HIS B  500  1                                  17    
HELIX   32 AD5 GLN B  510  ASN B  517  1                                   8    
HELIX   33 AD6 PRO B  519  PHE B  537  1                                  19    
HELIX   34 AD7 ALA K   12  ALA K   25  1                                  14    
HELIX   35 AD8 SER C   11  ASP C   23  1                                  13    
HELIX   36 AD9 ARG C   24  ALA C   27  5                                   4    
HELIX   37 AE1 ALA C   28  SER C   45  1                                  18    
HELIX   38 AE2 ALA C   49  LEU C   73  1                                  25    
HELIX   39 AE3 SER C   75  GLU C   94  1                                  20    
HELIX   40 AE4 ILE C  100  ALA C  121  1                                  22    
HELIX   41 AE5 ILE C  125  ARG C  139  1                                  15    
HELIX   42 AE6 PHE C  147  ALA C  161  1                                  15    
HELIX   43 AE7 LEU C  171  LEU C  177  1                                   7    
HELIX   44 AE8 PRO C  186  MET C  208  1                                  23    
HELIX   45 AE9 LYS C  216  ASN C  233  1                                  18    
HELIX   46 AF1 GLU C  239  VAL C  252  1                                  14    
HELIX   47 AF2 ASP C  261  LEU C  274  1                                  14    
HELIX   48 AF3 LEU C  286  THR C  304  1                                  19    
HELIX   49 AF4 LYS C  309  ASN C  330  1                                  22    
HELIX   50 AF5 LYS C  335  ASN C  355  1                                  21    
HELIX   51 AF6 LEU C  359  GLY C  371  1                                  13    
HELIX   52 AF7 VAL C  386  LEU C  397  1                                  12    
HELIX   53 AF8 THR C  398  ASP C  401  5                                   4    
HELIX   54 AF9 TYR C  408  LEU C  424  1                                  17    
HELIX   55 AG1 TYR C  431  ILE C  443  1                                  13    
HELIX   56 AG2 LYS C  452  GLY C  472  1                                  21    
HELIX   57 AG3 VAL C  474  ILE C  490  1                                  17    
HELIX   58 AG4 ASP C  529  MET C  540  1                                  12    
HELIX   59 AG5 ILE C  544  TYR C  565  1                                  22    
HELIX   60 AG6 GLU C  567  GLU C  584  1                                  18    
HELIX   61 AG7 GLN C  586  ALA C  597  1                                  12    
HELIX   62 AG8 SER C  606  SER C  621  1                                  16    
HELIX   63 AG9 GLN C  638  PHE C  649  1                                  12    
HELIX   64 AH1 SER C  650  GLU C  652  5                                   3    
HELIX   65 AH2 THR C  658  TYR C  667  1                                  10    
HELIX   66 AH3 LEU C  670  TYR C  682  1                                  13    
HELIX   67 AH4 TYR C  701  PHE C  710  1                                  10    
HELIX   68 AH5 PHE C  710  TYR C  721  1                                  12    
HELIX   69 AH6 LEU C  725  LEU C  736  1                                  12    
HELIX   70 AH7 LEU C  736  ILE C  741  1                                   6    
HELIX   71 AH8 PRO C  750  THR C  763  1                                  14    
HELIX   72 AH9 GLU C  767  HIS C  783  1                                  17    
HELIX   73 AI1 TYR C  788  LEU C  805  1                                  18    
HELIX   74 AI2 SER C  847  GLY C  863  1                                  17    
HELIX   75 AI3 LYS C  868  SER C  875  1                                   8    
HELIX   76 AI4 TYR C  883  GLU C  889  1                                   7    
HELIX   77 AI5 VAL C  909  LEU C  919  1                                  11    
HELIX   78 AI6 ALA C  921  ARG C  924  5                                   4    
HELIX   79 AI7 GLN C  925  THR C  946  1                                  22    
HELIX   80 AI8 GLU C  950  PHE C  966  1                                  17    
HELIX   81 AI9 PHE C  966  ASP C  977  1                                  12    
HELIX   82 AJ1 ASP C  977  ASN C  998  1                                  22    
HELIX   83 AJ2 PHE C 1001  ILE C 1013  1                                  13    
HELIX   84 AJ3 ASP C 1022  LYS C 1042  1                                  21    
HELIX   85 AJ4 THR C 1045  LYS C 1051  1                                   7    
HELIX   86 AJ5 ASN C 1055  HIS C 1069  1                                  15    
HELIX   87 AJ6 ALA C 1072  LYS C 1074  5                                   3    
HELIX   88 AJ7 ARG C 1075  ARG C 1090  1                                  16    
HELIX   89 AJ8 VAL C 1096  ALA C 1116  1                                  21    
HELIX   90 AJ9 GLY C 1122  HIS C 1133  1                                  12    
HELIX   91 AK1 ALA C 1148  PHE C 1157  1                                  10    
HELIX   92 AK2 CYS C 1164  CYS C 1176  1                                  13    
HELIX   93 AK3 GLY C 1216  PHE C 1219  5                                   4    
HELIX   94 AK4 LEU C 1220  GLY C 1227  1                                   8    
HELIX   95 AK5 ALA C 1237  ARG C 1245  1                                   9    
HELIX   96 AK6 PRO C 1247  GLN C 1251  5                                   5    
HELIX   97 AK7 TRP C 1256  PHE C 1270  1                                  15    
HELIX   98 AK8 ALA C 1278  LEU C 1282  5                                   5    
HELIX   99 AK9 LYS C 1292  ALA C 1308  1                                  17    
HELIX  100 AL1 PRO C 1324  THR C 1351  1                                  28    
HELIX  101 AL2 CYS C 1364  VAL C 1373  1                                  10    
HELIX  102 AL3 LEU C 1376  ILE C 1382  1                                   7    
HELIX  103 AL4 PHE C 1384  VAL C 1389  5                                   6    
HELIX  104 AL5 HIS C 1394  LEU C 1406  1                                  13    
HELIX  105 AL6 TYR C 1411  LYS C 1422  1                                  12    
HELIX  106 AL7 THR C 1424  GLY C 1438  1                                  15    
HELIX  107 AL8 ALA C 1441  GLY C 1462  1                                  22    
HELIX  108 AL9 THR C 1473  LEU C 1486  1                                  14    
HELIX  109 AM1 VAL C 1487  LYS C 1489  5                                   3    
HELIX  110 AM2 PRO C 1493  LYS C 1508  1                                  16    
HELIX  111 AM3 GLY C 1513  CYS C 1525  1                                  13    
HELIX  112 AM4 SER C 1549  TYR C 1560  1                                  12    
HELIX  113 AM5 TYR C 1560  THR C 1566  1                                   7    
HELIX  114 AM6 THR C 1566  LEU C 1577  1                                  12    
HELIX  115 AM7 LEU C 1580  THR C 1590  1                                  11    
HELIX  116 AM8 MET C 1592  ALA C 1609  1                                  18    
HELIX  117 AM9 LYS C 1635  LEU C 1646  1                                  12    
HELIX  118 AN1 LEU C 1646  ASP C 1656  1                                  11    
HELIX  119 AN2 PHE C 1672  LEU C 1696  1                                  25    
HELIX  120 AN3 LEU C 1710  ILE C 1718  1                                   9    
HELIX  121 AN4 MET C 1724  PHE C 1729  1                                   6    
HELIX  122 AN5 TYR C 1739  SER C 1755  1                                  17    
HELIX  123 AN6 TYR C 1802  LYS C 1807  1                                   6    
HELIX  124 AN7 SER C 1813  ASP C 1821  1                                   9    
HELIX  125 AN8 LYS C 1857  GLY C 1872  1                                  16    
HELIX  126 AN9 ASP C 1878  LYS C 1892  1                                  15    
HELIX  127 AO1 LYS C 1895  THR C 1912  1                                  18    
HELIX  128 AO2 LYS C 1913  ALA C 1928  1                                  16    
HELIX  129 AO3 LEU C 1934  VAL C 1951  1                                  18    
HELIX  130 AO4 PHE C 1956  PHE C 1965  1                                  10    
HELIX  131 AO5 PHE C 1978  GLU C 1999  1                                  22    
HELIX  132 AO6 ALA C 2014  GLY C 2021  1                                   8    
HELIX  133 AO7 THR C 2035  GLN C 2042  1                                   8    
HELIX  134 AO8 GLN C 2042  SER C 2056  1                                  15    
HELIX  135 AO9 ASP C 2058  GLY C 2064  1                                   7    
HELIX  136 AP1 ARG C 2072  VAL C 2076  5                                   5    
HELIX  137 AP2 MET C 2085  ARG C 2090  1                                   6    
HELIX  138 AP3 CYS C 2093  LEU C 2108  1                                  16    
HELIX  139 AP4 SER C 2117  ASP C 2121  5                                   5    
HELIX  140 AP5 ILE C 2137  ILE C 2151  1                                  15    
HELIX  141 AP6 VAL C 2156  SER C 2166  1                                  11    
HELIX  142 AP7 LEU C 2169  SER C 2174  1                                   6    
HELIX  143 AP8 GLU C 2180  THR C 2192  1                                  13    
HELIX  144 AP9 ILE C 2193  TRP C 2196  5                                   4    
HELIX  145 AQ1 THR C 2197  GLY C 2198  5                                   2    
HELIX  146 AQ2 LEU C 2199  VAL C 2205  1                                   7    
HELIX  147 AQ3 VAL C 2210  VAL C 2230  1                                  21    
HELIX  148 AQ4 ARG C 2232  LYS C 2246  1                                  15    
HELIX  149 AQ5 PRO C 2252  SER C 2261  1                                  10    
HELIX  150 AQ6 ASP C 2269  ALA C 2282  1                                  14    
HELIX  151 AQ7 GLU C 2298  PHE C 2309  1                                  12    
HELIX  152 AQ8 GLU C 2314  GLU C 2332  1                                  19    
HELIX  153 AQ9 ASN C 2335  MET C 2356  1                                  22    
HELIX  154 AR1 GLU C 2357  LYS C 2369  1                                  13    
HELIX  155 AR2 ALA C 2375  LEU C 2393  1                                  19    
HELIX  156 AR3 LEU C 2398  THR C 2409  1                                  12    
HELIX  157 AR4 TYR C 2412  GLN C 2414  5                                   3    
HELIX  158 AR5 LEU C 2415  PHE C 2420  1                                   6    
HELIX  159 AR6 VAL C 2421  ARG C 2427  5                                   7    
HELIX  160 AR7 GLU C 2430  GLN C 2432  5                                   3    
HELIX  161 AR8 LYS C 2433  ILE C 2439  1                                   7    
HELIX  162 AR9 VAL C 2449  ASN C 2456  1                                   8    
HELIX  163 AS1 THR C 2467  TYR C 2484  1                                  18    
HELIX  164 AS2 ASP C 2492  GLY C 2509  1                                  18    
HELIX  165 AS3 PRO C 2515  THR C 2529  1                                  15    
HELIX  166 AS4 THR C 2535  ASN C 2543  1                                   9    
HELIX  167 AS5 SER C 2544  ILE C 2550  5                                   7    
HELIX  168 AS6 HIS C 2553  SER C 2567  1                                  15    
HELIX  169 AS7 TYR C 2775  ILE C 2783  1                                   9    
HELIX  170 AS8 LEU C 2790  ASP C 2801  1                                  12    
HELIX  171 AS9 LYS C 2806  GLY C 2815  1                                  10    
HELIX  172 AT1 LYS C 2818  PHE C 2823  1                                   6    
HELIX  173 AT2 LEU C 2826  THR C 2847  1                                  22    
HELIX  174 AT3 PHE C 2851  CYS C 2863  1                                  13    
HELIX  175 AT4 ALA C 2866  LEU C 2871  1                                   6    
HELIX  176 AT5 PRO C 2873  ALA C 2878  1                                   6    
HELIX  177 AT6 ALA C 2882  LEU C 2884  5                                   3    
HELIX  178 AT7 GLN C 2885  ALA C 2896  1                                  12    
HELIX  179 AT8 LEU C 2900  GLU C 2904  5                                   5    
HELIX  180 AT9 ARG C 2911  VAL C 2924  1                                  14    
HELIX  181 AU1 ALA C 2927  ASP C 2937  1                                  11    
HELIX  182 AU2 ASP C 2937  ILE C 2942  1                                   6    
HELIX  183 AU3 SER C 2945  LEU C 2958  1                                  14    
HELIX  184 AU4 SER C 2963  ALA C 2975  1                                  13    
HELIX  185 AU5 ASN C 2977  VAL C 2982  1                                   6    
HELIX  186 AU6 ALA C 2989  GLU C 3007  1                                  19    
HELIX  187 AU7 TRP C 3008  ILE C 3019  1                                  12    
HELIX  188 AU8 PRO C 3024  LYS C 3029  1                                   6    
HELIX  189 AU9 TYR C 3036  THR C 3039  5                                   4    
HELIX  190 AV1 TYR C 3040  LEU C 3053  1                                  14    
HELIX  191 AV2 ASP C 3058  ALA C 3068  1                                  11    
HELIX  192 AV3 HIS C 3070  LYS C 3075  1                                   6    
HELIX  193 AV4 ALA C 3076  SER C 3083  1                                   8    
HELIX  194 AV5 GLN C 3084  ASP C 3094  1                                  11    
HELIX  195 AV6 ASP C 3097  SER C 3116  1                                  20    
HELIX  196 AV7 ARG C 3125  LEU C 3151  1                                  27    
HELIX  197 AV8 LEU C 3161  TYR C 3168  1                                   8    
HELIX  198 AV9 PRO C 3175  LEU C 3197  1                                  23    
HELIX  199 AW1 SER C 3228  ASN C 3250  1                                  23    
HELIX  200 AW2 PHE C 3252  SER C 3266  1                                  15    
HELIX  201 AW3 THR C 3268  ARG C 3289  1                                  22    
HELIX  202 AW4 GLU C 3295  LYS C 3302  1                                   8    
HELIX  203 AW5 ASP C 3308  VAL C 3312  5                                   5    
HELIX  204 AW6 SER C 3317  ARG C 3335  1                                  19    
HELIX  205 AW7 ASN C 3339  GLU C 3344  1                                   6    
HELIX  206 AW8 CYS C 3347  ARG C 3358  1                                  12    
HELIX  207 AW9 ILE C 3374  CYS C 3403  1                                  30    
HELIX  208 AX1 GLY C 3408  ASN C 3430  1                                  23    
HELIX  209 AX2 SER C 3432  GLN C 3440  1                                   9    
HELIX  210 AX3 TYR C 3442  GLU C 3448  1                                   7    
HELIX  211 AX4 LYS C 3449  LEU C 3451  5                                   3    
HELIX  212 AX5 SER C 3458  ILE C 3472  1                                  15    
HELIX  213 AX6 GLU C 3477  VAL C 3490  1                                  14    
HELIX  214 AX7 PRO C 3491  SER C 3497  5                                   7    
HELIX  215 AX8 TRP C 3498  LEU C 3506  1                                   9    
HELIX  216 AX9 HIS C 3516  TYR C 3525  1                                  10    
HELIX  217 AY1 TYR C 3531  LYS C 3543  1                                  13    
HELIX  218 AY2 GLY C 3548  GLN C 3564  1                                  17    
HELIX  219 AY3 GLY C 3566  ASP C 3576  1                                  11    
HELIX  220 AY4 PRO C 3581  LEU C 3596  1                                  16    
HELIX  221 AY5 ASN C 3602  ARG C 3612  1                                  11    
HELIX  222 AY6 ALA C 3622  ARG C 3629  1                                   8    
HELIX  223 AY7 ARG C 3630  PHE C 3636  1                                   7    
HELIX  224 AY8 LYS C 3638  LYS C 3655  1                                  18    
HELIX  225 AY9 ASP C 3658  ASP C 3673  1                                  16    
HELIX  226 AZ1 GLU C 3682  MET C 3687  1                                   6    
HELIX  227 AZ2 GLU C 3693  GLU C 3698  1                                   6    
HELIX  228 AZ3 ARG C 3759  ASP C 3778  1                                  20    
HELIX  229 AZ4 ASP C 3778  ARG C 3784  1                                   7    
HELIX  230 AZ5 LEU C 3812  GLU C 3824  1                                  13    
HELIX  231 AZ6 ARG C 3833  SER C 3847  1                                  15    
HELIX  232 AZ7 LYS C 3860  SER C 3891  1                                  32    
HELIX  233 AZ8 SER C 3893  LEU C 3918  1                                  26    
HELIX  234 AZ9 GLY C 3947  PHE C 3952  1                                   6    
HELIX  235 BA1 THR C 3964  LEU C 3972  1                                   9    
HELIX  236 BA2 LYS C 3975  ARG C 3992  1                                  18    
HELIX  237 BA3 PRO C 3995  GLU C 4008  1                                  14    
HELIX  238 BA4 TRP C 4013  LYS C 4023  1                                  11    
HELIX  239 BA5 SER C 4026  LYS C 4036  1                                  11    
HELIX  240 BA6 ARG C 4041  ALA C 4054  1                                  14    
HELIX  241 BA7 VAL C 4058  HIS C 4068  1                                  11    
HELIX  242 BA8 ALA C 4073  ALA C 4081  1                                   9    
HELIX  243 BA9 HIS C 4087  GLU C 4093  1                                   7    
HELIX  244 BB1 GLU C 4100  ALA C 4111  1                                  12    
HELIX  245 BB2 ASP C 4113  GLY C 4118  1                                   6    
SHEET    1 AA1 5 ILE A 102  ASP A 109  0                                        
SHEET    2 AA1 5 LEU A  82  TYR A  88 -1  N  PHE A  87   O  TYR A 103           
SHEET    3 AA1 5 SER A  37  VAL A  42  1  N  LEU A  38   O  LEU A  82           
SHEET    4 AA1 5 ARG A 165  PHE A 169  1  O  ARG A 165   N  ILE A  39           
SHEET    5 AA1 5 PHE A 199  ASP A 201  1  O  PHE A 199   N  ILE A 166           
SHEET    1 AA2 3 ARG A 258  LYS A 262  0                                        
SHEET    2 AA2 3 VAL A 268  GLY A 272 -1  O  ILE A 269   N  LEU A 261           
SHEET    3 AA2 3 TYR A 369  PRO A 370 -1  O  TYR A 369   N  GLY A 272           
SHEET    1 AA3 4 GLU A 294  PRO A 295  0                                        
SHEET    2 AA3 4 ILE A 286  TYR A 289 -1  N  TYR A 289   O  GLU A 294           
SHEET    3 AA3 4 ILE B 311  TYR B 316 -1  O  GLY B 313   N  ILE A 286           
SHEET    4 AA3 4 ASP B 319  VAL B 321 -1  O  VAL B 321   N  PHE B 314           
SHEET    1 AA4 2 THR A 302  PHE A 303  0                                        
SHEET    2 AA4 2 LEU A 310  LEU A 311 -1  O  LEU A 311   N  THR A 302           
SHEET    1 AA5 2 ARG A 318  ILE A 321  0                                        
SHEET    2 AA5 2 GLN A 326  LEU A 329 -1  O  ILE A 327   N  GLN A 320           
SHEET    1 AA6 4 LEU A 347  PRO A 352  0                                        
SHEET    2 AA6 4 VAL A 394  TYR A 400 -1  O  LEU A 397   N  MET A 348           
SHEET    3 AA6 4 TYR A 409  GLN A 416 -1  O  VAL A 411   N  CYS A 398           
SHEET    4 AA6 4 GLY A 431  PHE A 436 -1  O  VAL A 435   N  ALA A 412           
SHEET    1 AA7 5 THR B  78  VAL B  79  0                                        
SHEET    2 AA7 5 LYS B  51  PHE B  59 -1  N  LEU B  58   O  THR B  78           
SHEET    3 AA7 5 LYS B   7  ASP B  15  1  N  MET B  14   O  PHE B  59           
SHEET    4 AA7 5 LYS B 129  PHE B 135  1  O  PHE B 135   N  CYS B  13           
SHEET    5 AA7 5 ILE B 159  PHE B 164  1  O  SER B 160   N  ILE B 132           
SHEET    1 AA8 8 TRP B 247  ILE B 253  0                                        
SHEET    2 AA8 8 LEU B 257  ALA B 263 -1  O  LEU B 257   N  ILE B 253           
SHEET    3 AA8 8 MET B 357  ALA B 366 -1  O  PHE B 365   N  ALA B 262           
SHEET    4 AA8 8 CYS B 418  GLN B 423 -1  O  TYR B 421   N  LEU B 362           
SHEET    5 AA8 8 VAL B 405  HIS B 411 -1  N  VAL B 407   O  VAL B 422           
SHEET    6 AA8 8 MET B 389  ALA B 396 -1  N  ALA B 391   O  ALA B 408           
SHEET    7 AA8 8 CYS B 339  LYS B 347 -1  N  LEU B 343   O  ILE B 392           
SHEET    8 AA8 8 TRP B 247  ILE B 253  1  N  THR B 252   O  VAL B 342           
SHEET    1 AA9 2 TYR B 295  CYS B 296  0                                        
SHEET    2 AA9 2 GLU B 304  VAL B 305 -1  O  VAL B 305   N  TYR B 295           
SHEET    1 AB1 2 ALA B 464  ASP B 467  0                                        
SHEET    2 AB1 2 THR B 472  ASP B 475 -1  O  GLU B 474   N  LYS B 465           
SHEET    1 AB2 5 THR C3727  VAL C3728  0                                        
SHEET    2 AB2 5 LYS C3736  ARG C3741 -1  O  ARG C3737   N  THR C3727           
SHEET    3 AB2 5 GLU C3747  LYS C3753 -1  O  HIS C3748   N  ILE C3740           
SHEET    4 AB2 5 LEU C3800  ILE C3803 -1  O  GLY C3801   N  LYS C3753           
SHEET    5 AB2 5 VAL C3793  THR C3797 -1  N  VAL C3794   O  LEU C3802           
SHEET    1 AB3 3 THR C3809  THR C3811  0                                        
SHEET    2 AB3 3 PHE C3928  ALA C3931 -1  O  VAL C3930   N  VAL C3810           
SHEET    3 AB3 3 GLY C3936  GLY C3939 -1  O  ILE C3938   N  MET C3929           
CISPEP   1 SER C  492    LYS C  493          0        -9.01                     
CISPEP   2 LEU C 1975    LEU C 1976          0        -7.07                     
CISPEP   3 PHE C 2066    ARG C 2067          0        -5.45                     
CISPEP   4 GLU C 2070    GLN C 2071          0         7.55                     
CISPEP   5 LEU C 3151    SER C 3152          0        -3.16                     
CISPEP   6 SER C 3152    SER C 3153          0        -2.10                     
CISPEP   7 LEU C 3578    SER C 3579          0        16.51                     
CISPEP   8 MET C 3974    LYS C 3975          0        22.02                     
CISPEP   9 GLU C 4069    LYS C 4070          0         9.11                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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