HEADER TRANSPORT PROTEIN 02-OCT-17 5YI5
TITLE HUMAN FERRITIN MUTANT - E-HELIX DELETION
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: FERRITIN HEAVY CHAIN;
COMPND 3 CHAIN: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U,
COMPND 4 V, W, X;
COMPND 5 SYNONYM: FERRITIN H SUBUNIT,CELL PROLIFERATION-INDUCING GENE 15
COMPND 6 PROTEIN;
COMPND 7 EC: 1.16.3.1;
COMPND 8 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: FTH1, FTH, FTHL6, OK/SW-CL.84, PIG15;
SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS FERRITIN, CAGE, DRUG DELIVERY, TRANSPORT PROTEIN
EXPDTA ELECTRON MICROSCOPY
AUTHOR S.G.LEE,H.R.YOON,B.J.AHN,H.JEONG,J.HYUN,Y.JUNG,H.KIM
REVDAT 4 27-MAR-24 5YI5 1 REMARK
REVDAT 3 06-NOV-19 5YI5 1 CRYST1
REVDAT 2 14-MAR-18 5YI5 1 JRNL
REVDAT 1 21-FEB-18 5YI5 0
JRNL AUTH B.AHN,S.G.LEE,H.R.YOON,J.M.LEE,H.J.OH,H.M.KIM,Y.JUNG
JRNL TITL FOUR-FOLD CHANNEL-NICKED HUMAN FERRITIN NANOCAGES FOR ACTIVE
JRNL TITL 2 DRUG LOADING AND PH-RESPONSIVE DRUG RELEASE
JRNL REF ANGEW. CHEM. INT. ED. ENGL. V. 57 2909 2018
JRNL REFN ESSN 1521-3773
JRNL PMID 29359486
JRNL DOI 10.1002/ANIE.201800516
REMARK 2
REMARK 2 RESOLUTION. 3.00 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : RELION, CTFFIND, UCSF CHIMERA, RELION,
REMARK 3 RELION, RELION, RELION, PHENIX
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : 4Y08
REMARK 3 REFINEMENT SPACE : REAL
REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : 29.560
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.000
REMARK 3 NUMBER OF PARTICLES : 429135
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: RELION2.0 PROGRAM WAS USED FOR THE RECONSTRUCTION
REMARK 4
REMARK 4 5YI5 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 06-OCT-17.
REMARK 100 THE DEPOSITION ID IS D_1300005316.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : HUMAN FERRITIN E-HELIX DELETION
REMARK 245 MUTANT
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.05
REMARK 245 SAMPLE SUPPORT DETAILS : THE GRID WAS COATED WITH
REMARK 245 GRAPHENE OXIDE PRIOR TO USE
REMARK 245 SAMPLE VITRIFICATION DETAILS : BLOT FOR 9 SECONDS BEFORE
REMARK 245 PLUNGING
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.20
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : FEI FALCON II (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : 0.00
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 200.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : 47000
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 24-MERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,
REMARK 350 AND CHAINS: K, L, M, N, O, P, Q, R, S,
REMARK 350 AND CHAINS: T, U, V, W, X
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 THR A 2
REMARK 465 THR A 3
REMARK 465 ALA A 4
REMARK 465 SER A 5
REMARK 465 MET B 1
REMARK 465 THR B 2
REMARK 465 THR B 3
REMARK 465 ALA B 4
REMARK 465 SER B 5
REMARK 465 MET C 1
REMARK 465 THR C 2
REMARK 465 THR C 3
REMARK 465 ALA C 4
REMARK 465 SER C 5
REMARK 465 MET D 1
REMARK 465 THR D 2
REMARK 465 THR D 3
REMARK 465 ALA D 4
REMARK 465 SER D 5
REMARK 465 MET E 1
REMARK 465 THR E 2
REMARK 465 THR E 3
REMARK 465 ALA E 4
REMARK 465 SER E 5
REMARK 465 MET F 1
REMARK 465 THR F 2
REMARK 465 THR F 3
REMARK 465 ALA F 4
REMARK 465 SER F 5
REMARK 465 MET G 1
REMARK 465 THR G 2
REMARK 465 THR G 3
REMARK 465 ALA G 4
REMARK 465 SER G 5
REMARK 465 MET H 1
REMARK 465 THR H 2
REMARK 465 THR H 3
REMARK 465 ALA H 4
REMARK 465 SER H 5
REMARK 465 MET I 1
REMARK 465 THR I 2
REMARK 465 THR I 3
REMARK 465 ALA I 4
REMARK 465 SER I 5
REMARK 465 MET J 1
REMARK 465 THR J 2
REMARK 465 THR J 3
REMARK 465 ALA J 4
REMARK 465 SER J 5
REMARK 465 MET K 1
REMARK 465 THR K 2
REMARK 465 THR K 3
REMARK 465 ALA K 4
REMARK 465 SER K 5
REMARK 465 MET L 1
REMARK 465 THR L 2
REMARK 465 THR L 3
REMARK 465 ALA L 4
REMARK 465 SER L 5
REMARK 465 MET M 1
REMARK 465 THR M 2
REMARK 465 THR M 3
REMARK 465 ALA M 4
REMARK 465 SER M 5
REMARK 465 MET N 1
REMARK 465 THR N 2
REMARK 465 THR N 3
REMARK 465 ALA N 4
REMARK 465 SER N 5
REMARK 465 MET O 1
REMARK 465 THR O 2
REMARK 465 THR O 3
REMARK 465 ALA O 4
REMARK 465 SER O 5
REMARK 465 MET P 1
REMARK 465 THR P 2
REMARK 465 THR P 3
REMARK 465 ALA P 4
REMARK 465 SER P 5
REMARK 465 MET Q 1
REMARK 465 THR Q 2
REMARK 465 THR Q 3
REMARK 465 ALA Q 4
REMARK 465 SER Q 5
REMARK 465 MET R 1
REMARK 465 THR R 2
REMARK 465 THR R 3
REMARK 465 ALA R 4
REMARK 465 SER R 5
REMARK 465 MET S 1
REMARK 465 THR S 2
REMARK 465 THR S 3
REMARK 465 ALA S 4
REMARK 465 SER S 5
REMARK 465 MET T 1
REMARK 465 THR T 2
REMARK 465 THR T 3
REMARK 465 ALA T 4
REMARK 465 SER T 5
REMARK 465 MET U 1
REMARK 465 THR U 2
REMARK 465 THR U 3
REMARK 465 ALA U 4
REMARK 465 SER U 5
REMARK 465 MET V 1
REMARK 465 THR V 2
REMARK 465 THR V 3
REMARK 465 ALA V 4
REMARK 465 SER V 5
REMARK 465 MET W 1
REMARK 465 THR W 2
REMARK 465 THR W 3
REMARK 465 ALA W 4
REMARK 465 SER W 5
REMARK 465 MET X 1
REMARK 465 THR X 2
REMARK 465 THR X 3
REMARK 465 ALA X 4
REMARK 465 SER X 5
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 GLN A 15 CG CD OE1 NE2
REMARK 470 GLN B 15 CG CD OE1 NE2
REMARK 470 GLN C 15 CG CD OE1 NE2
REMARK 470 GLN D 15 CG CD OE1 NE2
REMARK 470 GLN E 15 CG CD OE1 NE2
REMARK 470 GLN F 15 CG CD OE1 NE2
REMARK 470 GLN G 15 CG CD OE1 NE2
REMARK 470 GLN H 15 CG CD OE1 NE2
REMARK 470 GLN I 15 CG CD OE1 NE2
REMARK 470 GLN J 15 CG CD OE1 NE2
REMARK 470 GLN K 15 CG CD OE1 NE2
REMARK 470 GLN L 15 CG CD OE1 NE2
REMARK 470 GLN M 15 CG CD OE1 NE2
REMARK 470 GLN N 15 CG CD OE1 NE2
REMARK 470 GLN O 15 CG CD OE1 NE2
REMARK 470 GLN P 15 CG CD OE1 NE2
REMARK 470 GLN Q 15 CG CD OE1 NE2
REMARK 470 GLN R 15 CG CD OE1 NE2
REMARK 470 GLN S 15 CG CD OE1 NE2
REMARK 470 GLN T 15 CG CD OE1 NE2
REMARK 470 GLN U 15 CG CD OE1 NE2
REMARK 470 GLN V 15 CG CD OE1 NE2
REMARK 470 GLN W 15 CG CD OE1 NE2
REMARK 470 GLN X 15 CG CD OE1 NE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 VAL A 47 -63.75 -126.66
REMARK 500 GLU A 95 -17.19 76.98
REMARK 500 TYR A 138 -64.88 -127.65
REMARK 500 THR A 175 -61.87 -126.74
REMARK 500 VAL B 47 -63.77 -126.71
REMARK 500 GLU B 95 -17.27 77.06
REMARK 500 TYR B 138 -64.82 -127.62
REMARK 500 THR B 175 -61.86 -126.76
REMARK 500 VAL C 47 -63.73 -126.68
REMARK 500 GLU C 95 -17.19 76.99
REMARK 500 TYR C 138 -64.85 -127.61
REMARK 500 THR C 175 -61.91 -126.74
REMARK 500 VAL D 47 -63.72 -126.68
REMARK 500 GLU D 95 -17.22 76.98
REMARK 500 TYR D 138 -64.86 -127.66
REMARK 500 THR D 175 -61.92 -126.75
REMARK 500 VAL E 47 -63.77 -126.74
REMARK 500 GLU E 95 -17.18 76.97
REMARK 500 TYR E 138 -64.90 -127.61
REMARK 500 THR E 175 -61.79 -126.79
REMARK 500 VAL F 47 -63.74 -126.66
REMARK 500 GLU F 95 -17.24 76.98
REMARK 500 TYR F 138 -64.82 -127.72
REMARK 500 THR F 175 -61.89 -126.75
REMARK 500 VAL G 47 -63.75 -126.75
REMARK 500 GLU G 95 -17.14 76.91
REMARK 500 TYR G 138 -64.84 -127.70
REMARK 500 THR G 175 -61.90 -126.74
REMARK 500 VAL H 47 -63.74 -126.69
REMARK 500 GLU H 95 -17.25 77.01
REMARK 500 TYR H 138 -64.86 -127.68
REMARK 500 THR H 175 -61.91 -126.77
REMARK 500 VAL I 47 -63.82 -126.69
REMARK 500 GLU I 95 -17.22 76.93
REMARK 500 TYR I 138 -64.77 -127.65
REMARK 500 THR I 175 -61.84 -126.81
REMARK 500 VAL J 47 -63.79 -126.68
REMARK 500 GLU J 95 -17.16 76.92
REMARK 500 TYR J 138 -64.83 -127.67
REMARK 500 THR J 175 -61.87 -126.75
REMARK 500 VAL K 47 -63.79 -126.65
REMARK 500 GLU K 95 -17.20 77.00
REMARK 500 TYR K 138 -64.82 -127.66
REMARK 500 THR K 175 -61.80 -126.80
REMARK 500 VAL L 47 -63.78 -126.72
REMARK 500 GLU L 95 -17.17 76.95
REMARK 500 TYR L 138 -64.88 -127.66
REMARK 500 THR L 175 -61.86 -126.74
REMARK 500 VAL M 47 -63.75 -126.68
REMARK 500 GLU M 95 -17.17 76.99
REMARK 500
REMARK 500 THIS ENTRY HAS 96 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-6714 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-6830 RELATED DB: EMDB
REMARK 900 HUMAN FERRITIN MUTANT - E-HELIX DELETION
DBREF 5YI5 A 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 B 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 C 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 D 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 E 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 F 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 G 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 H 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 I 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 J 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 K 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 L 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 M 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 N 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 O 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 P 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 Q 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 R 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 S 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 T 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 U 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 V 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 W 1 177 UNP P02794 FRIH_HUMAN 1 177
DBREF 5YI5 X 1 177 UNP P02794 FRIH_HUMAN 1 177
SEQRES 1 A 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 A 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 A 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 A 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 A 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 A 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 A 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 A 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 A 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 A 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 A 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 A 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 A 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 A 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 B 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 B 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 B 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 B 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 B 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 B 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 B 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 B 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 B 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 B 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 B 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 B 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 B 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 B 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 C 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 C 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 C 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 C 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 C 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 C 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 C 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 C 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 C 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 C 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 C 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 C 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 C 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 C 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 D 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 D 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 D 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 D 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 D 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 D 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 D 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 D 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 D 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 D 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 D 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 D 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 D 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 D 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 E 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 E 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 E 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 E 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 E 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 E 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 E 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 E 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 E 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 E 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 E 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 E 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 E 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 E 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 F 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 F 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 F 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 F 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 F 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 F 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 F 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 F 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 F 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 F 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 F 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 F 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 F 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 F 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 G 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 G 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 G 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 G 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 G 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 G 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 G 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 G 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 G 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 G 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 G 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 G 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 G 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 G 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 H 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 H 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 H 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 H 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 H 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 H 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 H 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 H 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 H 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 H 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 H 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 H 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 H 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 H 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 I 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 I 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 I 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 I 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 I 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 I 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 I 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 I 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 I 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 I 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 I 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 I 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 I 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 I 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 J 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 J 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 J 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 J 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 J 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 J 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 J 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 J 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 J 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 J 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 J 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 J 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 J 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 J 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 K 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 K 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 K 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 K 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 K 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 K 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 K 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 K 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 K 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 K 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 K 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 K 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 K 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 K 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 L 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 L 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 L 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 L 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 L 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 L 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 L 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 L 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 L 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 L 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 L 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 L 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 L 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 L 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 M 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 M 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 M 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 M 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 M 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 M 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 M 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 M 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 M 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 M 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 M 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 M 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 M 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 M 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 N 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 N 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 N 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 N 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 N 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 N 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 N 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 N 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 N 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 N 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 N 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 N 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 N 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 N 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 O 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 O 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 O 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 O 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 O 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 O 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 O 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 O 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 O 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 O 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 O 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 O 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 O 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 O 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 P 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 P 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 P 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 P 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 P 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 P 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 P 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 P 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 P 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 P 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 P 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 P 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 P 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 P 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 Q 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 Q 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 Q 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 Q 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 Q 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 Q 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 Q 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 Q 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 Q 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 Q 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 Q 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 Q 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 Q 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 Q 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 R 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 R 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 R 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 R 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 R 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 R 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 R 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 R 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 R 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 R 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 R 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 R 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 R 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 R 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 S 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 S 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 S 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 S 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 S 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 S 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 S 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 S 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 S 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 S 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 S 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 S 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 S 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 S 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 T 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 T 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 T 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 T 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 T 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 T 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 T 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 T 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 T 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 T 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 T 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 T 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 T 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 T 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 U 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 U 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 U 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 U 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 U 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 U 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 U 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 U 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 U 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 U 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 U 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 U 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 U 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 U 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 V 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 V 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 V 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 V 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 V 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 V 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 V 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 V 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 V 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 V 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 V 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 V 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 V 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 V 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 W 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 W 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 W 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 W 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 W 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 W 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 W 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 W 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 W 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 W 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 W 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 W 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 W 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 W 177 LEU PHE ASP LYS HIS THR LEU GLY
SEQRES 1 X 177 MET THR THR ALA SER THR SER GLN VAL ARG GLN ASN TYR
SEQRES 2 X 177 HIS GLN ASP SER GLU ALA ALA ILE ASN ARG GLN ILE ASN
SEQRES 3 X 177 LEU GLU LEU TYR ALA SER TYR VAL TYR LEU SER MET SER
SEQRES 4 X 177 TYR TYR PHE ASP ARG ASP ASP VAL ALA LEU LYS ASN PHE
SEQRES 5 X 177 ALA LYS TYR PHE LEU HIS GLN SER HIS GLU GLU ARG GLU
SEQRES 6 X 177 HIS ALA GLU LYS LEU MET LYS LEU GLN ASN GLN ARG GLY
SEQRES 7 X 177 GLY ARG ILE PHE LEU GLN ASP ILE LYS LYS PRO ASP CYS
SEQRES 8 X 177 ASP ASP TRP GLU SER GLY LEU ASN ALA MET GLU CYS ALA
SEQRES 9 X 177 LEU HIS LEU GLU LYS ASN VAL ASN GLN SER LEU LEU GLU
SEQRES 10 X 177 LEU HIS LYS LEU ALA THR ASP LYS ASN ASP PRO HIS LEU
SEQRES 11 X 177 CYS ASP PHE ILE GLU THR HIS TYR LEU ASN GLU GLN VAL
SEQRES 12 X 177 LYS ALA ILE LYS GLU LEU GLY ASP HIS VAL THR ASN LEU
SEQRES 13 X 177 ARG LYS MET GLY ALA PRO GLU SER GLY LEU ALA GLU TYR
SEQRES 14 X 177 LEU PHE ASP LYS HIS THR LEU GLY
HELIX 1 AA1 ASP A 16 PHE A 42 1 27
HELIX 2 AA2 LEU A 49 ARG A 77 1 29
HELIX 3 AA3 SER A 96 LYS A 125 1 30
HELIX 4 AA4 ASP A 127 TYR A 138 1 12
HELIX 5 AA5 TYR A 138 GLY A 160 1 23
HELIX 6 AA6 SER A 164 GLY A 177 1 14
HELIX 7 AA7 ASP B 16 PHE B 42 1 27
HELIX 8 AA8 LEU B 49 ARG B 77 1 29
HELIX 9 AA9 SER B 96 LYS B 125 1 30
HELIX 10 AB1 ASP B 127 TYR B 138 1 12
HELIX 11 AB2 TYR B 138 GLY B 160 1 23
HELIX 12 AB3 SER B 164 GLY B 177 1 14
HELIX 13 AB4 ASP C 16 PHE C 42 1 27
HELIX 14 AB5 LEU C 49 ARG C 77 1 29
HELIX 15 AB6 SER C 96 LYS C 125 1 30
HELIX 16 AB7 ASP C 127 TYR C 138 1 12
HELIX 17 AB8 TYR C 138 GLY C 160 1 23
HELIX 18 AB9 SER C 164 GLY C 177 1 14
HELIX 19 AC1 ASP D 16 PHE D 42 1 27
HELIX 20 AC2 LEU D 49 ARG D 77 1 29
HELIX 21 AC3 SER D 96 LYS D 125 1 30
HELIX 22 AC4 ASP D 127 TYR D 138 1 12
HELIX 23 AC5 TYR D 138 GLY D 160 1 23
HELIX 24 AC6 SER D 164 GLY D 177 1 14
HELIX 25 AC7 ASP E 16 PHE E 42 1 27
HELIX 26 AC8 LEU E 49 ARG E 77 1 29
HELIX 27 AC9 SER E 96 LYS E 125 1 30
HELIX 28 AD1 ASP E 127 TYR E 138 1 12
HELIX 29 AD2 TYR E 138 GLY E 160 1 23
HELIX 30 AD3 SER E 164 GLY E 177 1 14
HELIX 31 AD4 ASP F 16 PHE F 42 1 27
HELIX 32 AD5 LEU F 49 ARG F 77 1 29
HELIX 33 AD6 SER F 96 LYS F 125 1 30
HELIX 34 AD7 ASP F 127 TYR F 138 1 12
HELIX 35 AD8 TYR F 138 GLY F 160 1 23
HELIX 36 AD9 SER F 164 GLY F 177 1 14
HELIX 37 AE1 ASP G 16 PHE G 42 1 27
HELIX 38 AE2 LEU G 49 ARG G 77 1 29
HELIX 39 AE3 SER G 96 LYS G 125 1 30
HELIX 40 AE4 ASP G 127 TYR G 138 1 12
HELIX 41 AE5 TYR G 138 GLY G 160 1 23
HELIX 42 AE6 SER G 164 GLY G 177 1 14
HELIX 43 AE7 ASP H 16 PHE H 42 1 27
HELIX 44 AE8 LEU H 49 ARG H 77 1 29
HELIX 45 AE9 SER H 96 LYS H 125 1 30
HELIX 46 AF1 ASP H 127 TYR H 138 1 12
HELIX 47 AF2 TYR H 138 GLY H 160 1 23
HELIX 48 AF3 SER H 164 GLY H 177 1 14
HELIX 49 AF4 ASP I 16 PHE I 42 1 27
HELIX 50 AF5 LEU I 49 ARG I 77 1 29
HELIX 51 AF6 SER I 96 LYS I 125 1 30
HELIX 52 AF7 ASP I 127 TYR I 138 1 12
HELIX 53 AF8 TYR I 138 GLY I 160 1 23
HELIX 54 AF9 SER I 164 GLY I 177 1 14
HELIX 55 AG1 ASP J 16 PHE J 42 1 27
HELIX 56 AG2 LEU J 49 ARG J 77 1 29
HELIX 57 AG3 SER J 96 LYS J 125 1 30
HELIX 58 AG4 ASP J 127 TYR J 138 1 12
HELIX 59 AG5 TYR J 138 GLY J 160 1 23
HELIX 60 AG6 SER J 164 GLY J 177 1 14
HELIX 61 AG7 ASP K 16 PHE K 42 1 27
HELIX 62 AG8 LEU K 49 ARG K 77 1 29
HELIX 63 AG9 SER K 96 LYS K 125 1 30
HELIX 64 AH1 ASP K 127 TYR K 138 1 12
HELIX 65 AH2 TYR K 138 GLY K 160 1 23
HELIX 66 AH3 SER K 164 GLY K 177 1 14
HELIX 67 AH4 ASP L 16 PHE L 42 1 27
HELIX 68 AH5 LEU L 49 ARG L 77 1 29
HELIX 69 AH6 SER L 96 LYS L 125 1 30
HELIX 70 AH7 ASP L 127 TYR L 138 1 12
HELIX 71 AH8 TYR L 138 GLY L 160 1 23
HELIX 72 AH9 SER L 164 GLY L 177 1 14
HELIX 73 AI1 ASP M 16 PHE M 42 1 27
HELIX 74 AI2 LEU M 49 ARG M 77 1 29
HELIX 75 AI3 SER M 96 LYS M 125 1 30
HELIX 76 AI4 ASP M 127 TYR M 138 1 12
HELIX 77 AI5 TYR M 138 GLY M 160 1 23
HELIX 78 AI6 SER M 164 GLY M 177 1 14
HELIX 79 AI7 ASP N 16 PHE N 42 1 27
HELIX 80 AI8 LEU N 49 ARG N 77 1 29
HELIX 81 AI9 SER N 96 LYS N 125 1 30
HELIX 82 AJ1 ASP N 127 TYR N 138 1 12
HELIX 83 AJ2 TYR N 138 GLY N 160 1 23
HELIX 84 AJ3 SER N 164 GLY N 177 1 14
HELIX 85 AJ4 ASP O 16 PHE O 42 1 27
HELIX 86 AJ5 LEU O 49 ARG O 77 1 29
HELIX 87 AJ6 SER O 96 LYS O 125 1 30
HELIX 88 AJ7 ASP O 127 TYR O 138 1 12
HELIX 89 AJ8 TYR O 138 GLY O 160 1 23
HELIX 90 AJ9 SER O 164 GLY O 177 1 14
HELIX 91 AK1 ASP P 16 PHE P 42 1 27
HELIX 92 AK2 LEU P 49 ARG P 77 1 29
HELIX 93 AK3 SER P 96 LYS P 125 1 30
HELIX 94 AK4 ASP P 127 TYR P 138 1 12
HELIX 95 AK5 TYR P 138 GLY P 160 1 23
HELIX 96 AK6 SER P 164 GLY P 177 1 14
HELIX 97 AK7 ASP Q 16 PHE Q 42 1 27
HELIX 98 AK8 LEU Q 49 ARG Q 77 1 29
HELIX 99 AK9 SER Q 96 LYS Q 125 1 30
HELIX 100 AL1 ASP Q 127 TYR Q 138 1 12
HELIX 101 AL2 TYR Q 138 GLY Q 160 1 23
HELIX 102 AL3 SER Q 164 GLY Q 177 1 14
HELIX 103 AL4 ASP R 16 PHE R 42 1 27
HELIX 104 AL5 LEU R 49 ARG R 77 1 29
HELIX 105 AL6 SER R 96 LYS R 125 1 30
HELIX 106 AL7 ASP R 127 TYR R 138 1 12
HELIX 107 AL8 TYR R 138 GLY R 160 1 23
HELIX 108 AL9 SER R 164 GLY R 177 1 14
HELIX 109 AM1 ASP S 16 PHE S 42 1 27
HELIX 110 AM2 LEU S 49 ARG S 77 1 29
HELIX 111 AM3 SER S 96 LYS S 125 1 30
HELIX 112 AM4 ASP S 127 TYR S 138 1 12
HELIX 113 AM5 TYR S 138 GLY S 160 1 23
HELIX 114 AM6 SER S 164 GLY S 177 1 14
HELIX 115 AM7 ASP T 16 PHE T 42 1 27
HELIX 116 AM8 LEU T 49 ARG T 77 1 29
HELIX 117 AM9 SER T 96 LYS T 125 1 30
HELIX 118 AN1 ASP T 127 TYR T 138 1 12
HELIX 119 AN2 TYR T 138 GLY T 160 1 23
HELIX 120 AN3 SER T 164 GLY T 177 1 14
HELIX 121 AN4 ASP U 16 PHE U 42 1 27
HELIX 122 AN5 LEU U 49 ARG U 77 1 29
HELIX 123 AN6 SER U 96 LYS U 125 1 30
HELIX 124 AN7 ASP U 127 TYR U 138 1 12
HELIX 125 AN8 TYR U 138 GLY U 160 1 23
HELIX 126 AN9 SER U 164 GLY U 177 1 14
HELIX 127 AO1 ASP V 16 PHE V 42 1 27
HELIX 128 AO2 LEU V 49 ARG V 77 1 29
HELIX 129 AO3 SER V 96 LYS V 125 1 30
HELIX 130 AO4 ASP V 127 TYR V 138 1 12
HELIX 131 AO5 TYR V 138 GLY V 160 1 23
HELIX 132 AO6 SER V 164 GLY V 177 1 14
HELIX 133 AO7 ASP W 16 PHE W 42 1 27
HELIX 134 AO8 LEU W 49 ARG W 77 1 29
HELIX 135 AO9 SER W 96 LYS W 125 1 30
HELIX 136 AP1 ASP W 127 TYR W 138 1 12
HELIX 137 AP2 TYR W 138 GLY W 160 1 23
HELIX 138 AP3 SER W 164 GLY W 177 1 14
HELIX 139 AP4 ASP X 16 PHE X 42 1 27
HELIX 140 AP5 LEU X 49 ARG X 77 1 29
HELIX 141 AP6 SER X 96 LYS X 125 1 30
HELIX 142 AP7 ASP X 127 TYR X 138 1 12
HELIX 143 AP8 TYR X 138 GLY X 160 1 23
HELIX 144 AP9 SER X 164 GLY X 177 1 14
CISPEP 1 ALA A 161 PRO A 162 0 -5.89
CISPEP 2 ALA B 161 PRO B 162 0 -5.88
CISPEP 3 ALA C 161 PRO C 162 0 -5.93
CISPEP 4 ALA D 161 PRO D 162 0 -5.91
CISPEP 5 ALA E 161 PRO E 162 0 -5.92
CISPEP 6 ALA F 161 PRO F 162 0 -5.92
CISPEP 7 ALA G 161 PRO G 162 0 -5.91
CISPEP 8 ALA H 161 PRO H 162 0 -5.90
CISPEP 9 ALA I 161 PRO I 162 0 -5.85
CISPEP 10 ALA J 161 PRO J 162 0 -5.95
CISPEP 11 ALA K 161 PRO K 162 0 -5.91
CISPEP 12 ALA L 161 PRO L 162 0 -5.91
CISPEP 13 ALA M 161 PRO M 162 0 -5.93
CISPEP 14 ALA N 161 PRO N 162 0 -5.94
CISPEP 15 ALA O 161 PRO O 162 0 -5.93
CISPEP 16 ALA P 161 PRO P 162 0 -5.96
CISPEP 17 ALA Q 161 PRO Q 162 0 -5.81
CISPEP 18 ALA R 161 PRO R 162 0 -5.87
CISPEP 19 ALA S 161 PRO S 162 0 -5.84
CISPEP 20 ALA T 161 PRO T 162 0 -5.89
CISPEP 21 ALA U 161 PRO U 162 0 -5.86
CISPEP 22 ALA V 161 PRO V 162 0 -5.87
CISPEP 23 ALA W 161 PRO W 162 0 -5.96
CISPEP 24 ALA X 161 PRO X 162 0 -5.91
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
