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Database: PDB
Entry: 5YKG
LinkDB: 5YKG
Original site: 5YKG 
HEADER    MEMBRANE PROTEIN                        14-OCT-17   5YKG              
TITLE     STRUCTURE OF PANCREATIC ATP-SENSITIVE POTASSIUM CHANNEL BOUND WITH    
TITLE    2 GLIBENCLAMIDE AND ATPGAMMAS (CLASS2 AT 4.57A)                        
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 11;       
COMPND   3 CHAIN: A, C, E, G;                                                   
COMPND   4 SYNONYM: INWARD RECTIFIER K(+) CHANNEL KIR6.2,POTASSIUM CHANNEL,     
COMPND   5 INWARDLY RECTIFYING SUBFAMILY J MEMBER 11;                           
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 ISOFORM X2;     
COMPND   9 CHAIN: B, D, F, H;                                                   
COMPND  10 SYNONYM: SUR1;                                                       
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE   3 ORGANISM_COMMON: MOUSE;                                              
SOURCE   4 ORGANISM_TAXID: 10090;                                               
SOURCE   5 GENE: KCNJ11;                                                        
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: MESOCRICETUS AURATUS;                           
SOURCE  11 ORGANISM_COMMON: GOLDEN HAMSTER;                                     
SOURCE  12 ORGANISM_TAXID: 10036;                                               
SOURCE  13 GENE: ABCC8;                                                         
SOURCE  14 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  15 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    KATP, CHANNEL, GLIBENCLAMIDE, SULFONYLUREA, MEMBRANE PROTEIN          
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    L.CHEN,J.X.WU                                                         
REVDAT   2   13-JUN-18 5YKG    1       JRNL                                     
REVDAT   1   18-APR-18 5YKG    0                                                
JRNL        AUTH   J.X.WU,D.DING,M.WANG,Y.KANG,X.ZENG,L.CHEN                    
JRNL        TITL   LIGAND BINDING AND CONFORMATIONAL CHANGES OF SUR1 SUBUNIT IN 
JRNL        TITL 2 PANCREATIC ATP-SENSITIVE POTASSIUM CHANNELS.                 
JRNL        REF    PROTEIN CELL                  V.   9   553 2018              
JRNL        REFN                   ESSN 1674-8018                               
JRNL        PMID   29594720                                                     
JRNL        DOI    10.1007/S13238-018-0530-Y                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.57 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION                                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.570                          
REMARK   3   NUMBER OF PARTICLES               : 40340                          
REMARK   3   CTF CORRECTION METHOD             : NONE                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 5YKG COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 18-OCT-17.                  
REMARK 100 THE DEPOSITION ID IS D_1300005440.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : KATP                              
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 QUANTUM (4K X 4K)     
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 50.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     LEU A     2                                                      
REMARK 465     SER A     3                                                      
REMARK 465     ARG A     4                                                      
REMARK 465     LYS A     5                                                      
REMARK 465     GLY A     6                                                      
REMARK 465     ILE A     7                                                      
REMARK 465     ILE A     8                                                      
REMARK 465     PRO A     9                                                      
REMARK 465     GLU A    10                                                      
REMARK 465     GLU A    11                                                      
REMARK 465     TYR A    12                                                      
REMARK 465     VAL A    13                                                      
REMARK 465     LEU A    14                                                      
REMARK 465     THR A    15                                                      
REMARK 465     ARG A    16                                                      
REMARK 465     LEU A    17                                                      
REMARK 465     ALA A    18                                                      
REMARK 465     GLU A    19                                                      
REMARK 465     ASP A    20                                                      
REMARK 465     PRO A    21                                                      
REMARK 465     ALA A    22                                                      
REMARK 465     GLU A    23                                                      
REMARK 465     PRO A    24                                                      
REMARK 465     ARG A    25                                                      
REMARK 465     TYR A    26                                                      
REMARK 465     ARG A    27                                                      
REMARK 465     THR A    28                                                      
REMARK 465     ARG A    29                                                      
REMARK 465     GLU A    30                                                      
REMARK 465     ARG A    31                                                      
REMARK 465     ASP A   357                                                      
REMARK 465     ALA A   358                                                      
REMARK 465     LEU A   359                                                      
REMARK 465     THR A   360                                                      
REMARK 465     LEU A   361                                                      
REMARK 465     ALA A   362                                                      
REMARK 465     SER A   363                                                      
REMARK 465     SER A   364                                                      
REMARK 465     ARG A   365                                                      
REMARK 465     GLY A   366                                                      
REMARK 465     PRO A   367                                                      
REMARK 465     LEU A   368                                                      
REMARK 465     ARG A   369                                                      
REMARK 465     LYS A   370                                                      
REMARK 465     ARG A   371                                                      
REMARK 465     SER A   372                                                      
REMARK 465     VAL A   373                                                      
REMARK 465     ALA A   374                                                      
REMARK 465     VAL A   375                                                      
REMARK 465     ALA A   376                                                      
REMARK 465     LYS A   377                                                      
REMARK 465     ALA A   378                                                      
REMARK 465     LYS A   379                                                      
REMARK 465     PRO A   380                                                      
REMARK 465     LYS A   381                                                      
REMARK 465     PHE A   382                                                      
REMARK 465     SER A   383                                                      
REMARK 465     ILE A   384                                                      
REMARK 465     SER A   385                                                      
REMARK 465     PRO A   386                                                      
REMARK 465     ASP A   387                                                      
REMARK 465     SER A   388                                                      
REMARK 465     LEU A   389                                                      
REMARK 465     SER A   390                                                      
REMARK 465     MET B     1                                                      
REMARK 465     PRO B     2                                                      
REMARK 465     LEU B     3                                                      
REMARK 465     ALA B     4                                                      
REMARK 465     PHE B     5                                                      
REMARK 465     CYS B     6                                                      
REMARK 465     GLY B     7                                                      
REMARK 465     THR B     8                                                      
REMARK 465     GLU B     9                                                      
REMARK 465     ASN B    10                                                      
REMARK 465     HIS B    11                                                      
REMARK 465     SER B    12                                                      
REMARK 465     ALA B    13                                                      
REMARK 465     ALA B    14                                                      
REMARK 465     TYR B    15                                                      
REMARK 465     ARG B    16                                                      
REMARK 465     VAL B    17                                                      
REMARK 465     ASP B    18                                                      
REMARK 465     GLN B    19                                                      
REMARK 465     GLY B    20                                                      
REMARK 465     VAL B    21                                                      
REMARK 465     LEU B    22                                                      
REMARK 465     ASN B    23                                                      
REMARK 465     SER B    53                                                      
REMARK 465     GLN B    54                                                      
REMARK 465     SER B    55                                                      
REMARK 465     SER B    56                                                      
REMARK 465     LYS B    57                                                      
REMARK 465     VAL B    58                                                      
REMARK 465     HIS B    59                                                      
REMARK 465     ILE B    60                                                      
REMARK 465     HIS B    61                                                      
REMARK 465     HIS B    62                                                      
REMARK 465     GLY B    97                                                      
REMARK 465     VAL B    98                                                      
REMARK 465     THR B    99                                                      
REMARK 465     GLU B   100                                                      
REMARK 465     SER B   101                                                      
REMARK 465     ARG B   102                                                      
REMARK 465     ALA B   161                                                      
REMARK 465     ILE B   162                                                      
REMARK 465     GLY B   163                                                      
REMARK 465     PHE B   164                                                      
REMARK 465     SER B   165                                                      
REMARK 465     GLN B   166                                                      
REMARK 465     THR B   278                                                      
REMARK 465     GLN B   279                                                      
REMARK 465     SER B   280                                                      
REMARK 465     PRO B   281                                                      
REMARK 465     GLN B   282                                                      
REMARK 465     GLU B   330                                                      
REMARK 465     ASN B   331                                                      
REMARK 465     HIS B   332                                                      
REMARK 465     VAL B   333                                                      
REMARK 465     PHE B   334                                                      
REMARK 465     GLN B   335                                                      
REMARK 465     PRO B   336                                                      
REMARK 465     LYS B   337                                                      
REMARK 465     THR B   338                                                      
REMARK 465     GLN B   339                                                      
REMARK 465     PHE B   340                                                      
REMARK 465     LEU B   341                                                      
REMARK 465     GLY B   342                                                      
REMARK 465     VAL B   343                                                      
REMARK 465     TYR B   344                                                      
REMARK 465     PHE B   345                                                      
REMARK 465     VAL B   346                                                      
REMARK 465     SER B   347                                                      
REMARK 465     SER B   348                                                      
REMARK 465     GLN B   349                                                      
REMARK 465     GLU B   350                                                      
REMARK 465     PHE B   351                                                      
REMARK 465     LEU B   352                                                      
REMARK 465     GLY B   353                                                      
REMARK 465     LEU B   407                                                      
REMARK 465     SER B   408                                                      
REMARK 465     MET B   409                                                      
REMARK 465     GLY B   410                                                      
REMARK 465     ALA B   617                                                      
REMARK 465     GLU B   618                                                      
REMARK 465     ILE B   619                                                      
REMARK 465     ARG B   620                                                      
REMARK 465     GLU B   621                                                      
REMARK 465     GLU B   622                                                      
REMARK 465     GLN B   623                                                      
REMARK 465     CYS B   624                                                      
REMARK 465     ALA B   625                                                      
REMARK 465     PRO B   626                                                      
REMARK 465     ARG B   627                                                      
REMARK 465     GLU B   628                                                      
REMARK 465     PRO B   629                                                      
REMARK 465     ALA B   630                                                      
REMARK 465     PRO B   631                                                      
REMARK 465     GLN B   632                                                      
REMARK 465     GLY B   633                                                      
REMARK 465     GLN B   634                                                      
REMARK 465     ALA B   635                                                      
REMARK 465     GLY B   636                                                      
REMARK 465     LYS B   637                                                      
REMARK 465     TYR B   638                                                      
REMARK 465     GLN B   639                                                      
REMARK 465     ALA B   640                                                      
REMARK 465     VAL B   641                                                      
REMARK 465     PRO B   642                                                      
REMARK 465     LEU B   643                                                      
REMARK 465     LYS B   644                                                      
REMARK 465     VAL B   645                                                      
REMARK 465     VAL B   646                                                      
REMARK 465     ASN B   647                                                      
REMARK 465     ARG B   648                                                      
REMARK 465     LYS B   649                                                      
REMARK 465     ARG B   650                                                      
REMARK 465     PRO B   651                                                      
REMARK 465     ALA B   652                                                      
REMARK 465     ARG B   653                                                      
REMARK 465     GLU B   654                                                      
REMARK 465     GLU B   655                                                      
REMARK 465     VAL B   656                                                      
REMARK 465     ARG B   657                                                      
REMARK 465     ASP B   658                                                      
REMARK 465     LEU B   659                                                      
REMARK 465     LEU B   660                                                      
REMARK 465     GLY B   661                                                      
REMARK 465     PRO B   662                                                      
REMARK 465     LEU B   663                                                      
REMARK 465     GLN B   664                                                      
REMARK 465     ARG B   665                                                      
REMARK 465     LEU B   666                                                      
REMARK 465     ALA B   667                                                      
REMARK 465     PRO B   668                                                      
REMARK 465     SER B   669                                                      
REMARK 465     MET B   670                                                      
REMARK 465     ASP B   671                                                      
REMARK 465     GLY B   672                                                      
REMARK 465     ASP B   673                                                      
REMARK 465     ALA B   674                                                      
REMARK 465     ASP B   675                                                      
REMARK 465     ASN B   676                                                      
REMARK 465     PHE B   677                                                      
REMARK 465     ASN B   740                                                      
REMARK 465     SER B   741                                                      
REMARK 465     ASN B   742                                                      
REMARK 465     LEU B   743                                                      
REMARK 465     PRO B   744                                                      
REMARK 465     ASP B   745                                                      
REMARK 465     SER B   746                                                      
REMARK 465     GLU B   747                                                      
REMARK 465     GLY B   748                                                      
REMARK 465     GLU B   749                                                      
REMARK 465     ASP B   750                                                      
REMARK 465     PRO B   751                                                      
REMARK 465     SER B   752                                                      
REMARK 465     SER B   753                                                      
REMARK 465     PRO B   754                                                      
REMARK 465     GLU B   755                                                      
REMARK 465     ARG B   756                                                      
REMARK 465     GLU B   757                                                      
REMARK 465     THR B   758                                                      
REMARK 465     ALA B   759                                                      
REMARK 465     ALA B   760                                                      
REMARK 465     GLY B   761                                                      
REMARK 465     SER B   762                                                      
REMARK 465     ASP B   763                                                      
REMARK 465     ILE B   764                                                      
REMARK 465     ARG B   765                                                      
REMARK 465     SER B   766                                                      
REMARK 465     ARG B   767                                                      
REMARK 465     CYS B   922                                                      
REMARK 465     GLN B   923                                                      
REMARK 465     LEU B   924                                                      
REMARK 465     PHE B   925                                                      
REMARK 465     GLU B   926                                                      
REMARK 465     HIS B   927                                                      
REMARK 465     TRP B   928                                                      
REMARK 465     LYS B   929                                                      
REMARK 465     THR B   930                                                      
REMARK 465     LEU B   931                                                      
REMARK 465     MET B   932                                                      
REMARK 465     ASN B   933                                                      
REMARK 465     ARG B   934                                                      
REMARK 465     GLN B   935                                                      
REMARK 465     ASP B   936                                                      
REMARK 465     GLN B   937                                                      
REMARK 465     GLU B   938                                                      
REMARK 465     LEU B   939                                                      
REMARK 465     GLU B   940                                                      
REMARK 465     LYS B   941                                                      
REMARK 465     GLU B   942                                                      
REMARK 465     THR B   943                                                      
REMARK 465     VAL B   944                                                      
REMARK 465     MET B   945                                                      
REMARK 465     GLU B   946                                                      
REMARK 465     ARG B   947                                                      
REMARK 465     LYS B   948                                                      
REMARK 465     ALA B   949                                                      
REMARK 465     SER B   950                                                      
REMARK 465     GLU B   951                                                      
REMARK 465     PRO B   952                                                      
REMARK 465     SER B   953                                                      
REMARK 465     GLN B   954                                                      
REMARK 465     GLY B   955                                                      
REMARK 465     LEU B   956                                                      
REMARK 465     PRO B   957                                                      
REMARK 465     ARG B   958                                                      
REMARK 465     ALA B   959                                                      
REMARK 465     MET B   960                                                      
REMARK 465     SER B   961                                                      
REMARK 465     SER B   962                                                      
REMARK 465     ARG B   963                                                      
REMARK 465     ASP B   964                                                      
REMARK 465     GLY B   965                                                      
REMARK 465     LEU B   966                                                      
REMARK 465     LEU B   967                                                      
REMARK 465     LEU B   968                                                      
REMARK 465     ASP B   969                                                      
REMARK 465     GLU B   970                                                      
REMARK 465     GLU B   971                                                      
REMARK 465     GLU B   972                                                      
REMARK 465     GLU B   973                                                      
REMARK 465     GLU B   974                                                      
REMARK 465     GLU B   975                                                      
REMARK 465     GLU B   976                                                      
REMARK 465     ALA B   977                                                      
REMARK 465     ALA B   978                                                      
REMARK 465     GLU B   979                                                      
REMARK 465     SER B   980                                                      
REMARK 465     GLU B   981                                                      
REMARK 465     GLU B   982                                                      
REMARK 465     ASP B   983                                                      
REMARK 465     ASP B   984                                                      
REMARK 465     ASN B   985                                                      
REMARK 465     LEU B   986                                                      
REMARK 465     SER B   987                                                      
REMARK 465     SER B   988                                                      
REMARK 465     VAL B   989                                                      
REMARK 465     LEU B   990                                                      
REMARK 465     HIS B   991                                                      
REMARK 465     GLN B   992                                                      
REMARK 465     ARG B   993                                                      
REMARK 465     ALA B   994                                                      
REMARK 465     LYS B   995                                                      
REMARK 465     ALA B  1041                                                      
REMARK 465     LEU B  1042                                                      
REMARK 465     VAL B  1043                                                      
REMARK 465     LEU B  1044                                                      
REMARK 465     SER B  1045                                                      
REMARK 465     PRO B  1046                                                      
REMARK 465     ALA B  1047                                                      
REMARK 465     ALA B  1048                                                      
REMARK 465     ARG B  1049                                                      
REMARK 465     ASN B  1050                                                      
REMARK 465     CYS B  1051                                                      
REMARK 465     SER B  1052                                                      
REMARK 465     LEU B  1053                                                      
REMARK 465     SER B  1054                                                      
REMARK 465     GLN B  1055                                                      
REMARK 465     GLU B  1056                                                      
REMARK 465     CYS B  1057                                                      
REMARK 465     ASP B  1058                                                      
REMARK 465     LEU B  1059                                                      
REMARK 465     GLU B  1322                                                      
REMARK 465     ALA B  1323                                                      
REMARK 465     GLU B  1324                                                      
REMARK 465     SER B  1325                                                      
REMARK 465     TYR B  1326                                                      
REMARK 465     GLU B  1327                                                      
REMARK 465     GLY B  1328                                                      
REMARK 465     LEU B  1329                                                      
REMARK 465     LEU B  1330                                                      
REMARK 465     ALA B  1331                                                      
REMARK 465     ALA B  1580                                                      
REMARK 465     ASP B  1581                                                      
REMARK 465     LYS B  1582                                                      
REMARK 465     MET C     1                                                      
REMARK 465     LEU C     2                                                      
REMARK 465     SER C     3                                                      
REMARK 465     ARG C     4                                                      
REMARK 465     LYS C     5                                                      
REMARK 465     GLY C     6                                                      
REMARK 465     ILE C     7                                                      
REMARK 465     ILE C     8                                                      
REMARK 465     PRO C     9                                                      
REMARK 465     GLU C    10                                                      
REMARK 465     GLU C    11                                                      
REMARK 465     TYR C    12                                                      
REMARK 465     VAL C    13                                                      
REMARK 465     LEU C    14                                                      
REMARK 465     THR C    15                                                      
REMARK 465     ARG C    16                                                      
REMARK 465     LEU C    17                                                      
REMARK 465     ALA C    18                                                      
REMARK 465     GLU C    19                                                      
REMARK 465     ASP C    20                                                      
REMARK 465     PRO C    21                                                      
REMARK 465     ALA C    22                                                      
REMARK 465     GLU C    23                                                      
REMARK 465     PRO C    24                                                      
REMARK 465     ARG C    25                                                      
REMARK 465     TYR C    26                                                      
REMARK 465     ARG C    27                                                      
REMARK 465     THR C    28                                                      
REMARK 465     ARG C    29                                                      
REMARK 465     GLU C    30                                                      
REMARK 465     ARG C    31                                                      
REMARK 465     ASP C   357                                                      
REMARK 465     ALA C   358                                                      
REMARK 465     LEU C   359                                                      
REMARK 465     THR C   360                                                      
REMARK 465     LEU C   361                                                      
REMARK 465     ALA C   362                                                      
REMARK 465     SER C   363                                                      
REMARK 465     SER C   364                                                      
REMARK 465     ARG C   365                                                      
REMARK 465     GLY C   366                                                      
REMARK 465     PRO C   367                                                      
REMARK 465     LEU C   368                                                      
REMARK 465     ARG C   369                                                      
REMARK 465     LYS C   370                                                      
REMARK 465     ARG C   371                                                      
REMARK 465     SER C   372                                                      
REMARK 465     VAL C   373                                                      
REMARK 465     ALA C   374                                                      
REMARK 465     VAL C   375                                                      
REMARK 465     ALA C   376                                                      
REMARK 465     LYS C   377                                                      
REMARK 465     ALA C   378                                                      
REMARK 465     LYS C   379                                                      
REMARK 465     PRO C   380                                                      
REMARK 465     LYS C   381                                                      
REMARK 465     PHE C   382                                                      
REMARK 465     SER C   383                                                      
REMARK 465     ILE C   384                                                      
REMARK 465     SER C   385                                                      
REMARK 465     PRO C   386                                                      
REMARK 465     ASP C   387                                                      
REMARK 465     SER C   388                                                      
REMARK 465     LEU C   389                                                      
REMARK 465     SER C   390                                                      
REMARK 465     MET D     1                                                      
REMARK 465     PRO D     2                                                      
REMARK 465     LEU D     3                                                      
REMARK 465     ALA D     4                                                      
REMARK 465     PHE D     5                                                      
REMARK 465     CYS D     6                                                      
REMARK 465     GLY D     7                                                      
REMARK 465     THR D     8                                                      
REMARK 465     GLU D     9                                                      
REMARK 465     ASN D    10                                                      
REMARK 465     HIS D    11                                                      
REMARK 465     SER D    12                                                      
REMARK 465     ALA D    13                                                      
REMARK 465     ALA D    14                                                      
REMARK 465     TYR D    15                                                      
REMARK 465     ARG D    16                                                      
REMARK 465     VAL D    17                                                      
REMARK 465     ASP D    18                                                      
REMARK 465     GLN D    19                                                      
REMARK 465     GLY D    20                                                      
REMARK 465     VAL D    21                                                      
REMARK 465     LEU D    22                                                      
REMARK 465     ASN D    23                                                      
REMARK 465     SER D    53                                                      
REMARK 465     GLN D    54                                                      
REMARK 465     SER D    55                                                      
REMARK 465     SER D    56                                                      
REMARK 465     LYS D    57                                                      
REMARK 465     VAL D    58                                                      
REMARK 465     HIS D    59                                                      
REMARK 465     ILE D    60                                                      
REMARK 465     HIS D    61                                                      
REMARK 465     HIS D    62                                                      
REMARK 465     GLY D    97                                                      
REMARK 465     VAL D    98                                                      
REMARK 465     THR D    99                                                      
REMARK 465     GLU D   100                                                      
REMARK 465     SER D   101                                                      
REMARK 465     ARG D   102                                                      
REMARK 465     ALA D   161                                                      
REMARK 465     ILE D   162                                                      
REMARK 465     GLY D   163                                                      
REMARK 465     PHE D   164                                                      
REMARK 465     SER D   165                                                      
REMARK 465     GLN D   166                                                      
REMARK 465     THR D   278                                                      
REMARK 465     GLN D   279                                                      
REMARK 465     SER D   280                                                      
REMARK 465     PRO D   281                                                      
REMARK 465     GLN D   282                                                      
REMARK 465     GLU D   330                                                      
REMARK 465     ASN D   331                                                      
REMARK 465     HIS D   332                                                      
REMARK 465     VAL D   333                                                      
REMARK 465     PHE D   334                                                      
REMARK 465     GLN D   335                                                      
REMARK 465     PRO D   336                                                      
REMARK 465     LYS D   337                                                      
REMARK 465     THR D   338                                                      
REMARK 465     GLN D   339                                                      
REMARK 465     PHE D   340                                                      
REMARK 465     LEU D   341                                                      
REMARK 465     GLY D   342                                                      
REMARK 465     VAL D   343                                                      
REMARK 465     TYR D   344                                                      
REMARK 465     PHE D   345                                                      
REMARK 465     VAL D   346                                                      
REMARK 465     SER D   347                                                      
REMARK 465     SER D   348                                                      
REMARK 465     GLN D   349                                                      
REMARK 465     GLU D   350                                                      
REMARK 465     PHE D   351                                                      
REMARK 465     LEU D   352                                                      
REMARK 465     GLY D   353                                                      
REMARK 465     LEU D   407                                                      
REMARK 465     SER D   408                                                      
REMARK 465     MET D   409                                                      
REMARK 465     GLY D   410                                                      
REMARK 465     ALA D   617                                                      
REMARK 465     GLU D   618                                                      
REMARK 465     ILE D   619                                                      
REMARK 465     ARG D   620                                                      
REMARK 465     GLU D   621                                                      
REMARK 465     GLU D   622                                                      
REMARK 465     GLN D   623                                                      
REMARK 465     CYS D   624                                                      
REMARK 465     ALA D   625                                                      
REMARK 465     PRO D   626                                                      
REMARK 465     ARG D   627                                                      
REMARK 465     GLU D   628                                                      
REMARK 465     PRO D   629                                                      
REMARK 465     ALA D   630                                                      
REMARK 465     PRO D   631                                                      
REMARK 465     GLN D   632                                                      
REMARK 465     GLY D   633                                                      
REMARK 465     GLN D   634                                                      
REMARK 465     ALA D   635                                                      
REMARK 465     GLY D   636                                                      
REMARK 465     LYS D   637                                                      
REMARK 465     TYR D   638                                                      
REMARK 465     GLN D   639                                                      
REMARK 465     ALA D   640                                                      
REMARK 465     VAL D   641                                                      
REMARK 465     PRO D   642                                                      
REMARK 465     LEU D   643                                                      
REMARK 465     LYS D   644                                                      
REMARK 465     VAL D   645                                                      
REMARK 465     VAL D   646                                                      
REMARK 465     ASN D   647                                                      
REMARK 465     ARG D   648                                                      
REMARK 465     LYS D   649                                                      
REMARK 465     ARG D   650                                                      
REMARK 465     PRO D   651                                                      
REMARK 465     ALA D   652                                                      
REMARK 465     ARG D   653                                                      
REMARK 465     GLU D   654                                                      
REMARK 465     GLU D   655                                                      
REMARK 465     VAL D   656                                                      
REMARK 465     ARG D   657                                                      
REMARK 465     ASP D   658                                                      
REMARK 465     LEU D   659                                                      
REMARK 465     LEU D   660                                                      
REMARK 465     GLY D   661                                                      
REMARK 465     PRO D   662                                                      
REMARK 465     LEU D   663                                                      
REMARK 465     GLN D   664                                                      
REMARK 465     ARG D   665                                                      
REMARK 465     LEU D   666                                                      
REMARK 465     ALA D   667                                                      
REMARK 465     PRO D   668                                                      
REMARK 465     SER D   669                                                      
REMARK 465     MET D   670                                                      
REMARK 465     ASP D   671                                                      
REMARK 465     GLY D   672                                                      
REMARK 465     ASP D   673                                                      
REMARK 465     ALA D   674                                                      
REMARK 465     ASP D   675                                                      
REMARK 465     ASN D   676                                                      
REMARK 465     PHE D   677                                                      
REMARK 465     ASN D   740                                                      
REMARK 465     SER D   741                                                      
REMARK 465     ASN D   742                                                      
REMARK 465     LEU D   743                                                      
REMARK 465     PRO D   744                                                      
REMARK 465     ASP D   745                                                      
REMARK 465     SER D   746                                                      
REMARK 465     GLU D   747                                                      
REMARK 465     GLY D   748                                                      
REMARK 465     GLU D   749                                                      
REMARK 465     ASP D   750                                                      
REMARK 465     PRO D   751                                                      
REMARK 465     SER D   752                                                      
REMARK 465     SER D   753                                                      
REMARK 465     PRO D   754                                                      
REMARK 465     GLU D   755                                                      
REMARK 465     ARG D   756                                                      
REMARK 465     GLU D   757                                                      
REMARK 465     THR D   758                                                      
REMARK 465     ALA D   759                                                      
REMARK 465     ALA D   760                                                      
REMARK 465     GLY D   761                                                      
REMARK 465     SER D   762                                                      
REMARK 465     ASP D   763                                                      
REMARK 465     ILE D   764                                                      
REMARK 465     ARG D   765                                                      
REMARK 465     SER D   766                                                      
REMARK 465     ARG D   767                                                      
REMARK 465     CYS D   922                                                      
REMARK 465     GLN D   923                                                      
REMARK 465     LEU D   924                                                      
REMARK 465     PHE D   925                                                      
REMARK 465     GLU D   926                                                      
REMARK 465     HIS D   927                                                      
REMARK 465     TRP D   928                                                      
REMARK 465     LYS D   929                                                      
REMARK 465     THR D   930                                                      
REMARK 465     LEU D   931                                                      
REMARK 465     MET D   932                                                      
REMARK 465     ASN D   933                                                      
REMARK 465     ARG D   934                                                      
REMARK 465     GLN D   935                                                      
REMARK 465     ASP D   936                                                      
REMARK 465     GLN D   937                                                      
REMARK 465     GLU D   938                                                      
REMARK 465     LEU D   939                                                      
REMARK 465     GLU D   940                                                      
REMARK 465     LYS D   941                                                      
REMARK 465     GLU D   942                                                      
REMARK 465     THR D   943                                                      
REMARK 465     VAL D   944                                                      
REMARK 465     MET D   945                                                      
REMARK 465     GLU D   946                                                      
REMARK 465     ARG D   947                                                      
REMARK 465     LYS D   948                                                      
REMARK 465     ALA D   949                                                      
REMARK 465     SER D   950                                                      
REMARK 465     GLU D   951                                                      
REMARK 465     PRO D   952                                                      
REMARK 465     SER D   953                                                      
REMARK 465     GLN D   954                                                      
REMARK 465     GLY D   955                                                      
REMARK 465     LEU D   956                                                      
REMARK 465     PRO D   957                                                      
REMARK 465     ARG D   958                                                      
REMARK 465     ALA D   959                                                      
REMARK 465     MET D   960                                                      
REMARK 465     SER D   961                                                      
REMARK 465     SER D   962                                                      
REMARK 465     ARG D   963                                                      
REMARK 465     ASP D   964                                                      
REMARK 465     GLY D   965                                                      
REMARK 465     LEU D   966                                                      
REMARK 465     LEU D   967                                                      
REMARK 465     LEU D   968                                                      
REMARK 465     ASP D   969                                                      
REMARK 465     GLU D   970                                                      
REMARK 465     GLU D   971                                                      
REMARK 465     GLU D   972                                                      
REMARK 465     GLU D   973                                                      
REMARK 465     GLU D   974                                                      
REMARK 465     GLU D   975                                                      
REMARK 465     GLU D   976                                                      
REMARK 465     ALA D   977                                                      
REMARK 465     ALA D   978                                                      
REMARK 465     GLU D   979                                                      
REMARK 465     SER D   980                                                      
REMARK 465     GLU D   981                                                      
REMARK 465     GLU D   982                                                      
REMARK 465     ASP D   983                                                      
REMARK 465     ASP D   984                                                      
REMARK 465     ASN D   985                                                      
REMARK 465     LEU D   986                                                      
REMARK 465     SER D   987                                                      
REMARK 465     SER D   988                                                      
REMARK 465     VAL D   989                                                      
REMARK 465     LEU D   990                                                      
REMARK 465     HIS D   991                                                      
REMARK 465     GLN D   992                                                      
REMARK 465     ARG D   993                                                      
REMARK 465     ALA D   994                                                      
REMARK 465     LYS D   995                                                      
REMARK 465     ALA D  1041                                                      
REMARK 465     LEU D  1042                                                      
REMARK 465     VAL D  1043                                                      
REMARK 465     LEU D  1044                                                      
REMARK 465     SER D  1045                                                      
REMARK 465     PRO D  1046                                                      
REMARK 465     ALA D  1047                                                      
REMARK 465     ALA D  1048                                                      
REMARK 465     ARG D  1049                                                      
REMARK 465     ASN D  1050                                                      
REMARK 465     CYS D  1051                                                      
REMARK 465     SER D  1052                                                      
REMARK 465     LEU D  1053                                                      
REMARK 465     SER D  1054                                                      
REMARK 465     GLN D  1055                                                      
REMARK 465     GLU D  1056                                                      
REMARK 465     CYS D  1057                                                      
REMARK 465     ASP D  1058                                                      
REMARK 465     LEU D  1059                                                      
REMARK 465     GLU D  1322                                                      
REMARK 465     ALA D  1323                                                      
REMARK 465     GLU D  1324                                                      
REMARK 465     SER D  1325                                                      
REMARK 465     TYR D  1326                                                      
REMARK 465     GLU D  1327                                                      
REMARK 465     GLY D  1328                                                      
REMARK 465     LEU D  1329                                                      
REMARK 465     LEU D  1330                                                      
REMARK 465     ALA D  1331                                                      
REMARK 465     ALA D  1580                                                      
REMARK 465     ASP D  1581                                                      
REMARK 465     LYS D  1582                                                      
REMARK 465     MET E     1                                                      
REMARK 465     LEU E     2                                                      
REMARK 465     SER E     3                                                      
REMARK 465     ARG E     4                                                      
REMARK 465     LYS E     5                                                      
REMARK 465     GLY E     6                                                      
REMARK 465     ILE E     7                                                      
REMARK 465     ILE E     8                                                      
REMARK 465     PRO E     9                                                      
REMARK 465     GLU E    10                                                      
REMARK 465     GLU E    11                                                      
REMARK 465     TYR E    12                                                      
REMARK 465     VAL E    13                                                      
REMARK 465     LEU E    14                                                      
REMARK 465     THR E    15                                                      
REMARK 465     ARG E    16                                                      
REMARK 465     LEU E    17                                                      
REMARK 465     ALA E    18                                                      
REMARK 465     GLU E    19                                                      
REMARK 465     ASP E    20                                                      
REMARK 465     PRO E    21                                                      
REMARK 465     ALA E    22                                                      
REMARK 465     GLU E    23                                                      
REMARK 465     PRO E    24                                                      
REMARK 465     ARG E    25                                                      
REMARK 465     TYR E    26                                                      
REMARK 465     ARG E    27                                                      
REMARK 465     THR E    28                                                      
REMARK 465     ARG E    29                                                      
REMARK 465     GLU E    30                                                      
REMARK 465     ARG E    31                                                      
REMARK 465     ASP E   357                                                      
REMARK 465     ALA E   358                                                      
REMARK 465     LEU E   359                                                      
REMARK 465     THR E   360                                                      
REMARK 465     LEU E   361                                                      
REMARK 465     ALA E   362                                                      
REMARK 465     SER E   363                                                      
REMARK 465     SER E   364                                                      
REMARK 465     ARG E   365                                                      
REMARK 465     GLY E   366                                                      
REMARK 465     PRO E   367                                                      
REMARK 465     LEU E   368                                                      
REMARK 465     ARG E   369                                                      
REMARK 465     LYS E   370                                                      
REMARK 465     ARG E   371                                                      
REMARK 465     SER E   372                                                      
REMARK 465     VAL E   373                                                      
REMARK 465     ALA E   374                                                      
REMARK 465     VAL E   375                                                      
REMARK 465     ALA E   376                                                      
REMARK 465     LYS E   377                                                      
REMARK 465     ALA E   378                                                      
REMARK 465     LYS E   379                                                      
REMARK 465     PRO E   380                                                      
REMARK 465     LYS E   381                                                      
REMARK 465     PHE E   382                                                      
REMARK 465     SER E   383                                                      
REMARK 465     ILE E   384                                                      
REMARK 465     SER E   385                                                      
REMARK 465     PRO E   386                                                      
REMARK 465     ASP E   387                                                      
REMARK 465     SER E   388                                                      
REMARK 465     LEU E   389                                                      
REMARK 465     SER E   390                                                      
REMARK 465     MET F     1                                                      
REMARK 465     PRO F     2                                                      
REMARK 465     LEU F     3                                                      
REMARK 465     ALA F     4                                                      
REMARK 465     PHE F     5                                                      
REMARK 465     CYS F     6                                                      
REMARK 465     GLY F     7                                                      
REMARK 465     THR F     8                                                      
REMARK 465     GLU F     9                                                      
REMARK 465     ASN F    10                                                      
REMARK 465     HIS F    11                                                      
REMARK 465     SER F    12                                                      
REMARK 465     ALA F    13                                                      
REMARK 465     ALA F    14                                                      
REMARK 465     TYR F    15                                                      
REMARK 465     ARG F    16                                                      
REMARK 465     VAL F    17                                                      
REMARK 465     ASP F    18                                                      
REMARK 465     GLN F    19                                                      
REMARK 465     GLY F    20                                                      
REMARK 465     VAL F    21                                                      
REMARK 465     LEU F    22                                                      
REMARK 465     ASN F    23                                                      
REMARK 465     SER F    53                                                      
REMARK 465     GLN F    54                                                      
REMARK 465     SER F    55                                                      
REMARK 465     SER F    56                                                      
REMARK 465     LYS F    57                                                      
REMARK 465     VAL F    58                                                      
REMARK 465     HIS F    59                                                      
REMARK 465     ILE F    60                                                      
REMARK 465     HIS F    61                                                      
REMARK 465     HIS F    62                                                      
REMARK 465     GLY F    97                                                      
REMARK 465     VAL F    98                                                      
REMARK 465     THR F    99                                                      
REMARK 465     GLU F   100                                                      
REMARK 465     SER F   101                                                      
REMARK 465     ARG F   102                                                      
REMARK 465     ALA F   161                                                      
REMARK 465     ILE F   162                                                      
REMARK 465     GLY F   163                                                      
REMARK 465     PHE F   164                                                      
REMARK 465     SER F   165                                                      
REMARK 465     GLN F   166                                                      
REMARK 465     THR F   278                                                      
REMARK 465     GLN F   279                                                      
REMARK 465     SER F   280                                                      
REMARK 465     PRO F   281                                                      
REMARK 465     GLN F   282                                                      
REMARK 465     GLU F   330                                                      
REMARK 465     ASN F   331                                                      
REMARK 465     HIS F   332                                                      
REMARK 465     VAL F   333                                                      
REMARK 465     PHE F   334                                                      
REMARK 465     GLN F   335                                                      
REMARK 465     PRO F   336                                                      
REMARK 465     LYS F   337                                                      
REMARK 465     THR F   338                                                      
REMARK 465     GLN F   339                                                      
REMARK 465     PHE F   340                                                      
REMARK 465     LEU F   341                                                      
REMARK 465     GLY F   342                                                      
REMARK 465     VAL F   343                                                      
REMARK 465     TYR F   344                                                      
REMARK 465     PHE F   345                                                      
REMARK 465     VAL F   346                                                      
REMARK 465     SER F   347                                                      
REMARK 465     SER F   348                                                      
REMARK 465     GLN F   349                                                      
REMARK 465     GLU F   350                                                      
REMARK 465     PHE F   351                                                      
REMARK 465     LEU F   352                                                      
REMARK 465     GLY F   353                                                      
REMARK 465     LEU F   407                                                      
REMARK 465     SER F   408                                                      
REMARK 465     MET F   409                                                      
REMARK 465     GLY F   410                                                      
REMARK 465     ALA F   617                                                      
REMARK 465     GLU F   618                                                      
REMARK 465     ILE F   619                                                      
REMARK 465     ARG F   620                                                      
REMARK 465     GLU F   621                                                      
REMARK 465     GLU F   622                                                      
REMARK 465     GLN F   623                                                      
REMARK 465     CYS F   624                                                      
REMARK 465     ALA F   625                                                      
REMARK 465     PRO F   626                                                      
REMARK 465     ARG F   627                                                      
REMARK 465     GLU F   628                                                      
REMARK 465     PRO F   629                                                      
REMARK 465     ALA F   630                                                      
REMARK 465     PRO F   631                                                      
REMARK 465     GLN F   632                                                      
REMARK 465     GLY F   633                                                      
REMARK 465     GLN F   634                                                      
REMARK 465     ALA F   635                                                      
REMARK 465     GLY F   636                                                      
REMARK 465     LYS F   637                                                      
REMARK 465     TYR F   638                                                      
REMARK 465     GLN F   639                                                      
REMARK 465     ALA F   640                                                      
REMARK 465     VAL F   641                                                      
REMARK 465     PRO F   642                                                      
REMARK 465     LEU F   643                                                      
REMARK 465     LYS F   644                                                      
REMARK 465     VAL F   645                                                      
REMARK 465     VAL F   646                                                      
REMARK 465     ASN F   647                                                      
REMARK 465     ARG F   648                                                      
REMARK 465     LYS F   649                                                      
REMARK 465     ARG F   650                                                      
REMARK 465     PRO F   651                                                      
REMARK 465     ALA F   652                                                      
REMARK 465     ARG F   653                                                      
REMARK 465     GLU F   654                                                      
REMARK 465     GLU F   655                                                      
REMARK 465     VAL F   656                                                      
REMARK 465     ARG F   657                                                      
REMARK 465     ASP F   658                                                      
REMARK 465     LEU F   659                                                      
REMARK 465     LEU F   660                                                      
REMARK 465     GLY F   661                                                      
REMARK 465     PRO F   662                                                      
REMARK 465     LEU F   663                                                      
REMARK 465     GLN F   664                                                      
REMARK 465     ARG F   665                                                      
REMARK 465     LEU F   666                                                      
REMARK 465     ALA F   667                                                      
REMARK 465     PRO F   668                                                      
REMARK 465     SER F   669                                                      
REMARK 465     MET F   670                                                      
REMARK 465     ASP F   671                                                      
REMARK 465     GLY F   672                                                      
REMARK 465     ASP F   673                                                      
REMARK 465     ALA F   674                                                      
REMARK 465     ASP F   675                                                      
REMARK 465     ASN F   676                                                      
REMARK 465     PHE F   677                                                      
REMARK 465     ASN F   740                                                      
REMARK 465     SER F   741                                                      
REMARK 465     ASN F   742                                                      
REMARK 465     LEU F   743                                                      
REMARK 465     PRO F   744                                                      
REMARK 465     ASP F   745                                                      
REMARK 465     SER F   746                                                      
REMARK 465     GLU F   747                                                      
REMARK 465     GLY F   748                                                      
REMARK 465     GLU F   749                                                      
REMARK 465     ASP F   750                                                      
REMARK 465     PRO F   751                                                      
REMARK 465     SER F   752                                                      
REMARK 465     SER F   753                                                      
REMARK 465     PRO F   754                                                      
REMARK 465     GLU F   755                                                      
REMARK 465     ARG F   756                                                      
REMARK 465     GLU F   757                                                      
REMARK 465     THR F   758                                                      
REMARK 465     ALA F   759                                                      
REMARK 465     ALA F   760                                                      
REMARK 465     GLY F   761                                                      
REMARK 465     SER F   762                                                      
REMARK 465     ASP F   763                                                      
REMARK 465     ILE F   764                                                      
REMARK 465     ARG F   765                                                      
REMARK 465     SER F   766                                                      
REMARK 465     ARG F   767                                                      
REMARK 465     CYS F   922                                                      
REMARK 465     GLN F   923                                                      
REMARK 465     LEU F   924                                                      
REMARK 465     PHE F   925                                                      
REMARK 465     GLU F   926                                                      
REMARK 465     HIS F   927                                                      
REMARK 465     TRP F   928                                                      
REMARK 465     LYS F   929                                                      
REMARK 465     THR F   930                                                      
REMARK 465     LEU F   931                                                      
REMARK 465     MET F   932                                                      
REMARK 465     ASN F   933                                                      
REMARK 465     ARG F   934                                                      
REMARK 465     GLN F   935                                                      
REMARK 465     ASP F   936                                                      
REMARK 465     GLN F   937                                                      
REMARK 465     GLU F   938                                                      
REMARK 465     LEU F   939                                                      
REMARK 465     GLU F   940                                                      
REMARK 465     LYS F   941                                                      
REMARK 465     GLU F   942                                                      
REMARK 465     THR F   943                                                      
REMARK 465     VAL F   944                                                      
REMARK 465     MET F   945                                                      
REMARK 465     GLU F   946                                                      
REMARK 465     ARG F   947                                                      
REMARK 465     LYS F   948                                                      
REMARK 465     ALA F   949                                                      
REMARK 465     SER F   950                                                      
REMARK 465     GLU F   951                                                      
REMARK 465     PRO F   952                                                      
REMARK 465     SER F   953                                                      
REMARK 465     GLN F   954                                                      
REMARK 465     GLY F   955                                                      
REMARK 465     LEU F   956                                                      
REMARK 465     PRO F   957                                                      
REMARK 465     ARG F   958                                                      
REMARK 465     ALA F   959                                                      
REMARK 465     MET F   960                                                      
REMARK 465     SER F   961                                                      
REMARK 465     SER F   962                                                      
REMARK 465     ARG F   963                                                      
REMARK 465     ASP F   964                                                      
REMARK 465     GLY F   965                                                      
REMARK 465     LEU F   966                                                      
REMARK 465     LEU F   967                                                      
REMARK 465     LEU F   968                                                      
REMARK 465     ASP F   969                                                      
REMARK 465     GLU F   970                                                      
REMARK 465     GLU F   971                                                      
REMARK 465     GLU F   972                                                      
REMARK 465     GLU F   973                                                      
REMARK 465     GLU F   974                                                      
REMARK 465     GLU F   975                                                      
REMARK 465     GLU F   976                                                      
REMARK 465     ALA F   977                                                      
REMARK 465     ALA F   978                                                      
REMARK 465     GLU F   979                                                      
REMARK 465     SER F   980                                                      
REMARK 465     GLU F   981                                                      
REMARK 465     GLU F   982                                                      
REMARK 465     ASP F   983                                                      
REMARK 465     ASP F   984                                                      
REMARK 465     ASN F   985                                                      
REMARK 465     LEU F   986                                                      
REMARK 465     SER F   987                                                      
REMARK 465     SER F   988                                                      
REMARK 465     VAL F   989                                                      
REMARK 465     LEU F   990                                                      
REMARK 465     HIS F   991                                                      
REMARK 465     GLN F   992                                                      
REMARK 465     ARG F   993                                                      
REMARK 465     ALA F   994                                                      
REMARK 465     LYS F   995                                                      
REMARK 465     ALA F  1041                                                      
REMARK 465     LEU F  1042                                                      
REMARK 465     VAL F  1043                                                      
REMARK 465     LEU F  1044                                                      
REMARK 465     SER F  1045                                                      
REMARK 465     PRO F  1046                                                      
REMARK 465     ALA F  1047                                                      
REMARK 465     ALA F  1048                                                      
REMARK 465     ARG F  1049                                                      
REMARK 465     ASN F  1050                                                      
REMARK 465     CYS F  1051                                                      
REMARK 465     SER F  1052                                                      
REMARK 465     LEU F  1053                                                      
REMARK 465     SER F  1054                                                      
REMARK 465     GLN F  1055                                                      
REMARK 465     GLU F  1056                                                      
REMARK 465     CYS F  1057                                                      
REMARK 465     ASP F  1058                                                      
REMARK 465     LEU F  1059                                                      
REMARK 465     GLU F  1322                                                      
REMARK 465     ALA F  1323                                                      
REMARK 465     GLU F  1324                                                      
REMARK 465     SER F  1325                                                      
REMARK 465     TYR F  1326                                                      
REMARK 465     GLU F  1327                                                      
REMARK 465     GLY F  1328                                                      
REMARK 465     LEU F  1329                                                      
REMARK 465     LEU F  1330                                                      
REMARK 465     ALA F  1331                                                      
REMARK 465     ALA F  1580                                                      
REMARK 465     ASP F  1581                                                      
REMARK 465     LYS F  1582                                                      
REMARK 465     MET G     1                                                      
REMARK 465     LEU G     2                                                      
REMARK 465     SER G     3                                                      
REMARK 465     ARG G     4                                                      
REMARK 465     LYS G     5                                                      
REMARK 465     GLY G     6                                                      
REMARK 465     ILE G     7                                                      
REMARK 465     ILE G     8                                                      
REMARK 465     PRO G     9                                                      
REMARK 465     GLU G    10                                                      
REMARK 465     GLU G    11                                                      
REMARK 465     TYR G    12                                                      
REMARK 465     VAL G    13                                                      
REMARK 465     LEU G    14                                                      
REMARK 465     THR G    15                                                      
REMARK 465     ARG G    16                                                      
REMARK 465     LEU G    17                                                      
REMARK 465     ALA G    18                                                      
REMARK 465     GLU G    19                                                      
REMARK 465     ASP G    20                                                      
REMARK 465     PRO G    21                                                      
REMARK 465     ALA G    22                                                      
REMARK 465     GLU G    23                                                      
REMARK 465     PRO G    24                                                      
REMARK 465     ARG G    25                                                      
REMARK 465     TYR G    26                                                      
REMARK 465     ARG G    27                                                      
REMARK 465     THR G    28                                                      
REMARK 465     ARG G    29                                                      
REMARK 465     GLU G    30                                                      
REMARK 465     ARG G    31                                                      
REMARK 465     ASP G   357                                                      
REMARK 465     ALA G   358                                                      
REMARK 465     LEU G   359                                                      
REMARK 465     THR G   360                                                      
REMARK 465     LEU G   361                                                      
REMARK 465     ALA G   362                                                      
REMARK 465     SER G   363                                                      
REMARK 465     SER G   364                                                      
REMARK 465     ARG G   365                                                      
REMARK 465     GLY G   366                                                      
REMARK 465     PRO G   367                                                      
REMARK 465     LEU G   368                                                      
REMARK 465     ARG G   369                                                      
REMARK 465     LYS G   370                                                      
REMARK 465     ARG G   371                                                      
REMARK 465     SER G   372                                                      
REMARK 465     VAL G   373                                                      
REMARK 465     ALA G   374                                                      
REMARK 465     VAL G   375                                                      
REMARK 465     ALA G   376                                                      
REMARK 465     LYS G   377                                                      
REMARK 465     ALA G   378                                                      
REMARK 465     LYS G   379                                                      
REMARK 465     PRO G   380                                                      
REMARK 465     LYS G   381                                                      
REMARK 465     PHE G   382                                                      
REMARK 465     SER G   383                                                      
REMARK 465     ILE G   384                                                      
REMARK 465     SER G   385                                                      
REMARK 465     PRO G   386                                                      
REMARK 465     ASP G   387                                                      
REMARK 465     SER G   388                                                      
REMARK 465     LEU G   389                                                      
REMARK 465     SER G   390                                                      
REMARK 465     MET H     1                                                      
REMARK 465     PRO H     2                                                      
REMARK 465     LEU H     3                                                      
REMARK 465     ALA H     4                                                      
REMARK 465     PHE H     5                                                      
REMARK 465     CYS H     6                                                      
REMARK 465     GLY H     7                                                      
REMARK 465     THR H     8                                                      
REMARK 465     GLU H     9                                                      
REMARK 465     ASN H    10                                                      
REMARK 465     HIS H    11                                                      
REMARK 465     SER H    12                                                      
REMARK 465     ALA H    13                                                      
REMARK 465     ALA H    14                                                      
REMARK 465     TYR H    15                                                      
REMARK 465     ARG H    16                                                      
REMARK 465     VAL H    17                                                      
REMARK 465     ASP H    18                                                      
REMARK 465     GLN H    19                                                      
REMARK 465     GLY H    20                                                      
REMARK 465     VAL H    21                                                      
REMARK 465     LEU H    22                                                      
REMARK 465     ASN H    23                                                      
REMARK 465     SER H    53                                                      
REMARK 465     GLN H    54                                                      
REMARK 465     SER H    55                                                      
REMARK 465     SER H    56                                                      
REMARK 465     LYS H    57                                                      
REMARK 465     VAL H    58                                                      
REMARK 465     HIS H    59                                                      
REMARK 465     ILE H    60                                                      
REMARK 465     HIS H    61                                                      
REMARK 465     HIS H    62                                                      
REMARK 465     GLY H    97                                                      
REMARK 465     VAL H    98                                                      
REMARK 465     THR H    99                                                      
REMARK 465     GLU H   100                                                      
REMARK 465     SER H   101                                                      
REMARK 465     ARG H   102                                                      
REMARK 465     ALA H   161                                                      
REMARK 465     ILE H   162                                                      
REMARK 465     GLY H   163                                                      
REMARK 465     PHE H   164                                                      
REMARK 465     SER H   165                                                      
REMARK 465     GLN H   166                                                      
REMARK 465     THR H   278                                                      
REMARK 465     GLN H   279                                                      
REMARK 465     SER H   280                                                      
REMARK 465     PRO H   281                                                      
REMARK 465     GLN H   282                                                      
REMARK 465     GLU H   330                                                      
REMARK 465     ASN H   331                                                      
REMARK 465     HIS H   332                                                      
REMARK 465     VAL H   333                                                      
REMARK 465     PHE H   334                                                      
REMARK 465     GLN H   335                                                      
REMARK 465     PRO H   336                                                      
REMARK 465     LYS H   337                                                      
REMARK 465     THR H   338                                                      
REMARK 465     GLN H   339                                                      
REMARK 465     PHE H   340                                                      
REMARK 465     LEU H   341                                                      
REMARK 465     GLY H   342                                                      
REMARK 465     VAL H   343                                                      
REMARK 465     TYR H   344                                                      
REMARK 465     PHE H   345                                                      
REMARK 465     VAL H   346                                                      
REMARK 465     SER H   347                                                      
REMARK 465     SER H   348                                                      
REMARK 465     GLN H   349                                                      
REMARK 465     GLU H   350                                                      
REMARK 465     PHE H   351                                                      
REMARK 465     LEU H   352                                                      
REMARK 465     GLY H   353                                                      
REMARK 465     LEU H   407                                                      
REMARK 465     SER H   408                                                      
REMARK 465     MET H   409                                                      
REMARK 465     GLY H   410                                                      
REMARK 465     ALA H   617                                                      
REMARK 465     GLU H   618                                                      
REMARK 465     ILE H   619                                                      
REMARK 465     ARG H   620                                                      
REMARK 465     GLU H   621                                                      
REMARK 465     GLU H   622                                                      
REMARK 465     GLN H   623                                                      
REMARK 465     CYS H   624                                                      
REMARK 465     ALA H   625                                                      
REMARK 465     PRO H   626                                                      
REMARK 465     ARG H   627                                                      
REMARK 465     GLU H   628                                                      
REMARK 465     PRO H   629                                                      
REMARK 465     ALA H   630                                                      
REMARK 465     PRO H   631                                                      
REMARK 465     GLN H   632                                                      
REMARK 465     GLY H   633                                                      
REMARK 465     GLN H   634                                                      
REMARK 465     ALA H   635                                                      
REMARK 465     GLY H   636                                                      
REMARK 465     LYS H   637                                                      
REMARK 465     TYR H   638                                                      
REMARK 465     GLN H   639                                                      
REMARK 465     ALA H   640                                                      
REMARK 465     VAL H   641                                                      
REMARK 465     PRO H   642                                                      
REMARK 465     LEU H   643                                                      
REMARK 465     LYS H   644                                                      
REMARK 465     VAL H   645                                                      
REMARK 465     VAL H   646                                                      
REMARK 465     ASN H   647                                                      
REMARK 465     ARG H   648                                                      
REMARK 465     LYS H   649                                                      
REMARK 465     ARG H   650                                                      
REMARK 465     PRO H   651                                                      
REMARK 465     ALA H   652                                                      
REMARK 465     ARG H   653                                                      
REMARK 465     GLU H   654                                                      
REMARK 465     GLU H   655                                                      
REMARK 465     VAL H   656                                                      
REMARK 465     ARG H   657                                                      
REMARK 465     ASP H   658                                                      
REMARK 465     LEU H   659                                                      
REMARK 465     LEU H   660                                                      
REMARK 465     GLY H   661                                                      
REMARK 465     PRO H   662                                                      
REMARK 465     LEU H   663                                                      
REMARK 465     GLN H   664                                                      
REMARK 465     ARG H   665                                                      
REMARK 465     LEU H   666                                                      
REMARK 465     ALA H   667                                                      
REMARK 465     PRO H   668                                                      
REMARK 465     SER H   669                                                      
REMARK 465     MET H   670                                                      
REMARK 465     ASP H   671                                                      
REMARK 465     GLY H   672                                                      
REMARK 465     ASP H   673                                                      
REMARK 465     ALA H   674                                                      
REMARK 465     ASP H   675                                                      
REMARK 465     ASN H   676                                                      
REMARK 465     PHE H   677                                                      
REMARK 465     ASN H   740                                                      
REMARK 465     SER H   741                                                      
REMARK 465     ASN H   742                                                      
REMARK 465     LEU H   743                                                      
REMARK 465     PRO H   744                                                      
REMARK 465     ASP H   745                                                      
REMARK 465     SER H   746                                                      
REMARK 465     GLU H   747                                                      
REMARK 465     GLY H   748                                                      
REMARK 465     GLU H   749                                                      
REMARK 465     ASP H   750                                                      
REMARK 465     PRO H   751                                                      
REMARK 465     SER H   752                                                      
REMARK 465     SER H   753                                                      
REMARK 465     PRO H   754                                                      
REMARK 465     GLU H   755                                                      
REMARK 465     ARG H   756                                                      
REMARK 465     GLU H   757                                                      
REMARK 465     THR H   758                                                      
REMARK 465     ALA H   759                                                      
REMARK 465     ALA H   760                                                      
REMARK 465     GLY H   761                                                      
REMARK 465     SER H   762                                                      
REMARK 465     ASP H   763                                                      
REMARK 465     ILE H   764                                                      
REMARK 465     ARG H   765                                                      
REMARK 465     SER H   766                                                      
REMARK 465     ARG H   767                                                      
REMARK 465     CYS H   922                                                      
REMARK 465     GLN H   923                                                      
REMARK 465     LEU H   924                                                      
REMARK 465     PHE H   925                                                      
REMARK 465     GLU H   926                                                      
REMARK 465     HIS H   927                                                      
REMARK 465     TRP H   928                                                      
REMARK 465     LYS H   929                                                      
REMARK 465     THR H   930                                                      
REMARK 465     LEU H   931                                                      
REMARK 465     MET H   932                                                      
REMARK 465     ASN H   933                                                      
REMARK 465     ARG H   934                                                      
REMARK 465     GLN H   935                                                      
REMARK 465     ASP H   936                                                      
REMARK 465     GLN H   937                                                      
REMARK 465     GLU H   938                                                      
REMARK 465     LEU H   939                                                      
REMARK 465     GLU H   940                                                      
REMARK 465     LYS H   941                                                      
REMARK 465     GLU H   942                                                      
REMARK 465     THR H   943                                                      
REMARK 465     VAL H   944                                                      
REMARK 465     MET H   945                                                      
REMARK 465     GLU H   946                                                      
REMARK 465     ARG H   947                                                      
REMARK 465     LYS H   948                                                      
REMARK 465     ALA H   949                                                      
REMARK 465     SER H   950                                                      
REMARK 465     GLU H   951                                                      
REMARK 465     PRO H   952                                                      
REMARK 465     SER H   953                                                      
REMARK 465     GLN H   954                                                      
REMARK 465     GLY H   955                                                      
REMARK 465     LEU H   956                                                      
REMARK 465     PRO H   957                                                      
REMARK 465     ARG H   958                                                      
REMARK 465     ALA H   959                                                      
REMARK 465     MET H   960                                                      
REMARK 465     SER H   961                                                      
REMARK 465     SER H   962                                                      
REMARK 465     ARG H   963                                                      
REMARK 465     ASP H   964                                                      
REMARK 465     GLY H   965                                                      
REMARK 465     LEU H   966                                                      
REMARK 465     LEU H   967                                                      
REMARK 465     LEU H   968                                                      
REMARK 465     ASP H   969                                                      
REMARK 465     GLU H   970                                                      
REMARK 465     GLU H   971                                                      
REMARK 465     GLU H   972                                                      
REMARK 465     GLU H   973                                                      
REMARK 465     GLU H   974                                                      
REMARK 465     GLU H   975                                                      
REMARK 465     GLU H   976                                                      
REMARK 465     ALA H   977                                                      
REMARK 465     ALA H   978                                                      
REMARK 465     GLU H   979                                                      
REMARK 465     SER H   980                                                      
REMARK 465     GLU H   981                                                      
REMARK 465     GLU H   982                                                      
REMARK 465     ASP H   983                                                      
REMARK 465     ASP H   984                                                      
REMARK 465     ASN H   985                                                      
REMARK 465     LEU H   986                                                      
REMARK 465     SER H   987                                                      
REMARK 465     SER H   988                                                      
REMARK 465     VAL H   989                                                      
REMARK 465     LEU H   990                                                      
REMARK 465     HIS H   991                                                      
REMARK 465     GLN H   992                                                      
REMARK 465     ARG H   993                                                      
REMARK 465     ALA H   994                                                      
REMARK 465     LYS H   995                                                      
REMARK 465     ALA H  1041                                                      
REMARK 465     LEU H  1042                                                      
REMARK 465     VAL H  1043                                                      
REMARK 465     LEU H  1044                                                      
REMARK 465     SER H  1045                                                      
REMARK 465     PRO H  1046                                                      
REMARK 465     ALA H  1047                                                      
REMARK 465     ALA H  1048                                                      
REMARK 465     ARG H  1049                                                      
REMARK 465     ASN H  1050                                                      
REMARK 465     CYS H  1051                                                      
REMARK 465     SER H  1052                                                      
REMARK 465     LEU H  1053                                                      
REMARK 465     SER H  1054                                                      
REMARK 465     GLN H  1055                                                      
REMARK 465     GLU H  1056                                                      
REMARK 465     CYS H  1057                                                      
REMARK 465     ASP H  1058                                                      
REMARK 465     LEU H  1059                                                      
REMARK 465     GLU H  1322                                                      
REMARK 465     ALA H  1323                                                      
REMARK 465     GLU H  1324                                                      
REMARK 465     SER H  1325                                                      
REMARK 465     TYR H  1326                                                      
REMARK 465     GLU H  1327                                                      
REMARK 465     GLY H  1328                                                      
REMARK 465     LEU H  1329                                                      
REMARK 465     LEU H  1330                                                      
REMARK 465     ALA H  1331                                                      
REMARK 465     ALA H  1580                                                      
REMARK 465     ASP H  1581                                                      
REMARK 465     LYS H  1582                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU A  51    CG   CD   OE1  OE2                                  
REMARK 470     ARG A  54    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE A  55    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP A  99    CG   OD1  OD2                                       
REMARK 470     GLU A 104    CG   CD   OE1  OE2                                  
REMARK 470     THR A 106    OG1  CG2                                            
REMARK 470     GLU A 126    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 140    CG   CD   OE1  OE2                                  
REMARK 470     HIS A 175    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ARG A 176    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 177    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 179    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 192    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     CYS A 197    SG                                                  
REMARK 470     ILE A 211    CG1  CG2  CD1                                       
REMARK 470     LYS A 222    CG   CD   CE   NZ                                   
REMARK 470     GLU A 227    CG   CD   OE1  OE2                                  
REMARK 470     MET A 240    CG   SD   CE                                        
REMARK 470     ASN A 242    CB   CG   OD1  ND2                                  
REMARK 470     VAL A 244    CG1  CG2                                            
REMARK 470     LEU A 255    CG   CD1  CD2                                       
REMARK 470     ASP A 274    CG   OD1  OD2                                       
REMARK 470     HIS A 276    CG   ND1  CD2  CE1  NE2                             
REMARK 470     HIS A 278    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU A 282    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 322    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 353    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER A 354    OG                                                  
REMARK 470     LEU A 355    CG   CD1  CD2                                       
REMARK 470     LEU A 356    CG   CD1  CD2                                       
REMARK 470     ASP B  29    CG   OD1  OD2                                       
REMARK 470     LEU B  47    CG   CD1  CD2                                       
REMARK 470     ASP B  96    CG   OD1  OD2                                       
REMARK 470     HIS B 105    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU B 128    CG   CD   OE1  OE2                                  
REMARK 470     ILE B 141    CG1  CG2  CD1                                       
REMARK 470     CYS B 170    SG                                                  
REMARK 470     ARG B 194    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR B 195    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     PHE B 197    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE B 198    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS B 199    CG   CD   CE   NZ                                   
REMARK 470     ARG B 202    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B 203    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 208    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 209    CG   OD1  OD2                                       
REMARK 470     LEU B 210    CG   CD1  CD2                                       
REMARK 470     GLN B 211    CG   CD   OE1  NE2                                  
REMARK 470     ASP B 212    CG   OD1  OD2                                       
REMARK 470     LEU B 213    CG   CD1  CD2                                       
REMARK 470     PHE B 221    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG B 285    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B 310    CG   OD1  OD2                                       
REMARK 470     PHE B 314    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU B 411    CG   CD   OE1  OE2                                  
REMARK 470     MET B 412    CG   SD   CE                                        
REMARK 470     ASP B 424    CG   OD1  OD2                                       
REMARK 470     LEU B 469    CG   CD1  CD2                                       
REMARK 470     ASP B 691    CG   OD1  OD2                                       
REMARK 470     ASP B 905    CG   OD1  OD2                                       
REMARK 470     ARG B 910    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B 916    CG   OD1  OD2                                       
REMARK 470     GLU B 921    CG   CD   OE1  OE2                                  
REMARK 470     TRP B 998    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP B 998    CZ3  CH2                                            
REMARK 470     PHE B1164    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU B1456    CG   CD   OE1  OE2                                  
REMARK 470     ARG B1579    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C  51    CG   CD   OE1  OE2                                  
REMARK 470     ARG C  54    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE C  55    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP C  99    CG   OD1  OD2                                       
REMARK 470     GLU C 104    CG   CD   OE1  OE2                                  
REMARK 470     THR C 106    OG1  CG2                                            
REMARK 470     GLU C 126    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 140    CG   CD   OE1  OE2                                  
REMARK 470     HIS C 175    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ARG C 176    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C 177    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 179    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 192    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     CYS C 197    SG                                                  
REMARK 470     ILE C 211    CG1  CG2  CD1                                       
REMARK 470     LYS C 222    CG   CD   CE   NZ                                   
REMARK 470     GLU C 227    CG   CD   OE1  OE2                                  
REMARK 470     MET C 240    CG   SD   CE                                        
REMARK 470     ASN C 242    CB   CG   OD1  ND2                                  
REMARK 470     VAL C 244    CG1  CG2                                            
REMARK 470     LEU C 255    CG   CD1  CD2                                       
REMARK 470     ASP C 274    CG   OD1  OD2                                       
REMARK 470     HIS C 276    CG   ND1  CD2  CE1  NE2                             
REMARK 470     HIS C 278    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU C 282    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 322    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 353    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER C 354    OG                                                  
REMARK 470     LEU C 355    CG   CD1  CD2                                       
REMARK 470     LEU C 356    CG   CD1  CD2                                       
REMARK 470     ASP D  29    CG   OD1  OD2                                       
REMARK 470     LEU D  47    CG   CD1  CD2                                       
REMARK 470     ASP D  96    CG   OD1  OD2                                       
REMARK 470     HIS D 105    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU D 128    CG   CD   OE1  OE2                                  
REMARK 470     ILE D 141    CG1  CG2  CD1                                       
REMARK 470     CYS D 170    SG                                                  
REMARK 470     ARG D 194    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR D 195    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     PHE D 197    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE D 198    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS D 199    CG   CD   CE   NZ                                   
REMARK 470     ARG D 202    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D 203    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 208    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 209    CG   OD1  OD2                                       
REMARK 470     LEU D 210    CG   CD1  CD2                                       
REMARK 470     GLN D 211    CG   CD   OE1  NE2                                  
REMARK 470     ASP D 212    CG   OD1  OD2                                       
REMARK 470     LEU D 213    CG   CD1  CD2                                       
REMARK 470     PHE D 221    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG D 285    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP D 310    CG   OD1  OD2                                       
REMARK 470     PHE D 314    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU D 411    CG   CD   OE1  OE2                                  
REMARK 470     MET D 412    CG   SD   CE                                        
REMARK 470     ASP D 424    CG   OD1  OD2                                       
REMARK 470     LEU D 469    CG   CD1  CD2                                       
REMARK 470     ASP D 691    CG   OD1  OD2                                       
REMARK 470     ASP D 905    CG   OD1  OD2                                       
REMARK 470     ARG D 910    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP D 916    CG   OD1  OD2                                       
REMARK 470     GLU D 921    CG   CD   OE1  OE2                                  
REMARK 470     TRP D 998    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP D 998    CZ3  CH2                                            
REMARK 470     PHE D1164    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU D1456    CG   CD   OE1  OE2                                  
REMARK 470     ARG D1579    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E  51    CG   CD   OE1  OE2                                  
REMARK 470     ARG E  54    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE E  55    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP E  99    CG   OD1  OD2                                       
REMARK 470     GLU E 104    CG   CD   OE1  OE2                                  
REMARK 470     THR E 106    OG1  CG2                                            
REMARK 470     GLU E 126    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 140    CG   CD   OE1  OE2                                  
REMARK 470     HIS E 175    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ARG E 176    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E 177    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E 179    CG   CD   OE1  OE2                                  
REMARK 470     ARG E 192    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     CYS E 197    SG                                                  
REMARK 470     ILE E 211    CG1  CG2  CD1                                       
REMARK 470     LYS E 222    CG   CD   CE   NZ                                   
REMARK 470     GLU E 227    CG   CD   OE1  OE2                                  
REMARK 470     MET E 240    CG   SD   CE                                        
REMARK 470     ASN E 242    CB   CG   OD1  ND2                                  
REMARK 470     VAL E 244    CG1  CG2                                            
REMARK 470     LEU E 255    CG   CD1  CD2                                       
REMARK 470     ASP E 274    CG   OD1  OD2                                       
REMARK 470     HIS E 276    CG   ND1  CD2  CE1  NE2                             
REMARK 470     HIS E 278    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU E 282    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 322    CG   CD   OE1  OE2                                  
REMARK 470     ARG E 353    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER E 354    OG                                                  
REMARK 470     LEU E 355    CG   CD1  CD2                                       
REMARK 470     LEU E 356    CG   CD1  CD2                                       
REMARK 470     ASP F  29    CG   OD1  OD2                                       
REMARK 470     LEU F  47    CG   CD1  CD2                                       
REMARK 470     ASP F  96    CG   OD1  OD2                                       
REMARK 470     HIS F 105    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU F 128    CG   CD   OE1  OE2                                  
REMARK 470     ILE F 141    CG1  CG2  CD1                                       
REMARK 470     CYS F 170    SG                                                  
REMARK 470     ARG F 194    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR F 195    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     PHE F 197    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE F 198    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS F 199    CG   CD   CE   NZ                                   
REMARK 470     ARG F 202    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU F 203    CG   CD   OE1  OE2                                  
REMARK 470     GLU F 208    CG   CD   OE1  OE2                                  
REMARK 470     ASP F 209    CG   OD1  OD2                                       
REMARK 470     LEU F 210    CG   CD1  CD2                                       
REMARK 470     GLN F 211    CG   CD   OE1  NE2                                  
REMARK 470     ASP F 212    CG   OD1  OD2                                       
REMARK 470     LEU F 213    CG   CD1  CD2                                       
REMARK 470     PHE F 221    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG F 285    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP F 310    CG   OD1  OD2                                       
REMARK 470     PHE F 314    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU F 411    CG   CD   OE1  OE2                                  
REMARK 470     MET F 412    CG   SD   CE                                        
REMARK 470     ASP F 424    CG   OD1  OD2                                       
REMARK 470     LEU F 469    CG   CD1  CD2                                       
REMARK 470     ASP F 691    CG   OD1  OD2                                       
REMARK 470     ASP F 905    CG   OD1  OD2                                       
REMARK 470     ARG F 910    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP F 916    CG   OD1  OD2                                       
REMARK 470     GLU F 921    CG   CD   OE1  OE2                                  
REMARK 470     TRP F 998    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP F 998    CZ3  CH2                                            
REMARK 470     PHE F1164    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU F1456    CG   CD   OE1  OE2                                  
REMARK 470     ARG F1579    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G  51    CG   CD   OE1  OE2                                  
REMARK 470     ARG G  54    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE G  55    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP G  99    CG   OD1  OD2                                       
REMARK 470     GLU G 104    CG   CD   OE1  OE2                                  
REMARK 470     THR G 106    OG1  CG2                                            
REMARK 470     GLU G 126    CG   CD   OE1  OE2                                  
REMARK 470     GLU G 140    CG   CD   OE1  OE2                                  
REMARK 470     HIS G 175    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ARG G 176    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG G 177    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G 179    CG   CD   OE1  OE2                                  
REMARK 470     ARG G 192    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     CYS G 197    SG                                                  
REMARK 470     ILE G 211    CG1  CG2  CD1                                       
REMARK 470     LYS G 222    CG   CD   CE   NZ                                   
REMARK 470     GLU G 227    CG   CD   OE1  OE2                                  
REMARK 470     MET G 240    CG   SD   CE                                        
REMARK 470     ASN G 242    CB   CG   OD1  ND2                                  
REMARK 470     VAL G 244    CG1  CG2                                            
REMARK 470     LEU G 255    CG   CD1  CD2                                       
REMARK 470     ASP G 274    CG   OD1  OD2                                       
REMARK 470     HIS G 276    CG   ND1  CD2  CE1  NE2                             
REMARK 470     HIS G 278    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU G 282    CG   CD   OE1  OE2                                  
REMARK 470     GLU G 322    CG   CD   OE1  OE2                                  
REMARK 470     ARG G 353    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER G 354    OG                                                  
REMARK 470     LEU G 355    CG   CD1  CD2                                       
REMARK 470     LEU G 356    CG   CD1  CD2                                       
REMARK 470     ASP H  29    CG   OD1  OD2                                       
REMARK 470     LEU H  47    CG   CD1  CD2                                       
REMARK 470     ASP H  96    CG   OD1  OD2                                       
REMARK 470     HIS H 105    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU H 128    CG   CD   OE1  OE2                                  
REMARK 470     ILE H 141    CG1  CG2  CD1                                       
REMARK 470     CYS H 170    SG                                                  
REMARK 470     ARG H 194    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR H 195    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     PHE H 197    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE H 198    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS H 199    CG   CD   CE   NZ                                   
REMARK 470     ARG H 202    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H 203    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 208    CG   CD   OE1  OE2                                  
REMARK 470     ASP H 209    CG   OD1  OD2                                       
REMARK 470     LEU H 210    CG   CD1  CD2                                       
REMARK 470     GLN H 211    CG   CD   OE1  NE2                                  
REMARK 470     ASP H 212    CG   OD1  OD2                                       
REMARK 470     LEU H 213    CG   CD1  CD2                                       
REMARK 470     PHE H 221    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG H 285    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP H 310    CG   OD1  OD2                                       
REMARK 470     PHE H 314    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU H 411    CG   CD   OE1  OE2                                  
REMARK 470     MET H 412    CG   SD   CE                                        
REMARK 470     ASP H 424    CG   OD1  OD2                                       
REMARK 470     LEU H 469    CG   CD1  CD2                                       
REMARK 470     ASP H 691    CG   OD1  OD2                                       
REMARK 470     ASP H 905    CG   OD1  OD2                                       
REMARK 470     ARG H 910    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP H 916    CG   OD1  OD2                                       
REMARK 470     GLU H 921    CG   CD   OE1  OE2                                  
REMARK 470     TRP H 998    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP H 998    CZ3  CH2                                            
REMARK 470     PHE H1164    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU H1456    CG   CD   OE1  OE2                                  
REMARK 470     ARG H1579    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    GLU A  51       11.96     59.60                                   
REMARK 500    ASN A 242     -162.29   -117.90                                   
REMARK 500    VAL A 244      -34.50    -34.89                                   
REMARK 500    VAL A 252      -58.29   -123.64                                   
REMARK 500    GLU A 322     -165.57    -77.30                                   
REMARK 500    PHE B 198     -178.06    -62.24                                   
REMARK 500    LYS B 205       78.10     58.10                                   
REMARK 500    PRO B 206      141.88    -39.85                                   
REMARK 500    ASP B 212     -154.30    -78.20                                   
REMARK 500    PHE B 685      108.15   -160.38                                   
REMARK 500    TRP B 688       50.92    -93.86                                   
REMARK 500    ARG B 826       -5.44     72.90                                   
REMARK 500    ASP B 855       72.03     52.29                                   
REMARK 500    ILE B 873      -60.64    -99.83                                   
REMARK 500    THR B 888     -169.59   -165.72                                   
REMARK 500    LYS B1320       31.29    -93.91                                   
REMARK 500    ARG B1394       46.85     39.67                                   
REMARK 500    LEU B1471       14.17     57.34                                   
REMARK 500    SER B1501        1.31     82.37                                   
REMARK 500    ARG B1531       74.55     63.51                                   
REMARK 500    LYS B1553     -166.31    -79.32                                   
REMARK 500    GLU C  51       11.96     59.60                                   
REMARK 500    ASN C 242     -162.29   -117.90                                   
REMARK 500    VAL C 244      -34.50    -34.89                                   
REMARK 500    VAL C 252      -58.29   -123.64                                   
REMARK 500    GLU C 322     -165.57    -77.30                                   
REMARK 500    PHE D 198     -178.06    -62.24                                   
REMARK 500    LYS D 205       78.10     58.10                                   
REMARK 500    PRO D 206      141.88    -39.85                                   
REMARK 500    ASP D 212     -154.30    -78.20                                   
REMARK 500    PHE D 685      108.15   -160.38                                   
REMARK 500    TRP D 688       50.92    -93.86                                   
REMARK 500    ARG D 826       -5.44     72.90                                   
REMARK 500    ASP D 855       72.03     52.29                                   
REMARK 500    ILE D 873      -60.64    -99.83                                   
REMARK 500    THR D 888     -169.59   -165.72                                   
REMARK 500    LYS D1320       31.29    -93.91                                   
REMARK 500    ARG D1394       46.85     39.67                                   
REMARK 500    LEU D1471       14.17     57.34                                   
REMARK 500    SER D1501        1.31     82.37                                   
REMARK 500    ARG D1531       74.55     63.51                                   
REMARK 500    LYS D1553     -166.31    -79.32                                   
REMARK 500    GLU E  51       11.96     59.60                                   
REMARK 500    ASN E 242     -162.29   -117.90                                   
REMARK 500    VAL E 244      -34.50    -34.89                                   
REMARK 500    VAL E 252      -58.29   -123.64                                   
REMARK 500    GLU E 322     -165.57    -77.30                                   
REMARK 500    PHE F 198     -178.06    -62.24                                   
REMARK 500    LYS F 205       78.10     58.10                                   
REMARK 500    PRO F 206      141.88    -39.85                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      84 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue AGS A 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GBM B 2001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue AGS B 2002                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue AGS C 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GBM D 2001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue AGS D 2002                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue AGS E 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GBM F 2001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue AGS F 2002                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue AGS G 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GBM H 2001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue AGS H 2002                
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-6689   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-8470   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-6833   RELATED DB: EMDB                              
REMARK 900 STRUCTURE OF PANCREATIC ATP-SENSITIVE POTASSIUM CHANNEL BOUND WITH   
REMARK 900 GLIBENCLAMIDE AND ATPGAMMAS (CLASS2 AT 4.57A)                        
DBREF  5YKG A    1   390  UNP    Q61743   KCJ11_MOUSE      1    390             
DBREF1 5YKG B    1  1582  UNP                  A0A1U7R319_MESAU                 
DBREF2 5YKG B     A0A1U7R319                          1        1582             
DBREF  5YKG C    1   390  UNP    Q61743   KCJ11_MOUSE      1    390             
DBREF1 5YKG D    1  1582  UNP                  A0A1U7R319_MESAU                 
DBREF2 5YKG D     A0A1U7R319                          1        1582             
DBREF  5YKG E    1   390  UNP    Q61743   KCJ11_MOUSE      1    390             
DBREF1 5YKG F    1  1582  UNP                  A0A1U7R319_MESAU                 
DBREF2 5YKG F     A0A1U7R319                          1        1582             
DBREF  5YKG G    1   390  UNP    Q61743   KCJ11_MOUSE      1    390             
DBREF1 5YKG H    1  1582  UNP                  A0A1U7R319_MESAU                 
DBREF2 5YKG H     A0A1U7R319                          1        1582             
SEQRES   1 A  390  MET LEU SER ARG LYS GLY ILE ILE PRO GLU GLU TYR VAL          
SEQRES   2 A  390  LEU THR ARG LEU ALA GLU ASP PRO ALA GLU PRO ARG TYR          
SEQRES   3 A  390  ARG THR ARG GLU ARG ARG ALA ARG PHE VAL SER LYS LYS          
SEQRES   4 A  390  GLY ASN CYS ASN VAL ALA HIS LYS ASN ILE ARG GLU GLN          
SEQRES   5 A  390  GLY ARG PHE LEU GLN ASP VAL PHE THR THR LEU VAL ASP          
SEQRES   6 A  390  LEU LYS TRP PRO HIS THR LEU LEU ILE PHE THR MET SER          
SEQRES   7 A  390  PHE LEU CYS SER TRP LEU LEU PHE ALA MET VAL TRP TRP          
SEQRES   8 A  390  LEU ILE ALA PHE ALA HIS GLY ASP LEU ALA PRO GLY GLU          
SEQRES   9 A  390  GLY THR ASN VAL PRO CYS VAL THR SER ILE HIS SER PHE          
SEQRES  10 A  390  SER SER ALA PHE LEU PHE SER ILE GLU VAL GLN VAL THR          
SEQRES  11 A  390  ILE GLY PHE GLY GLY ARG MET VAL THR GLU GLU CYS PRO          
SEQRES  12 A  390  LEU ALA ILE LEU ILE LEU ILE VAL GLN ASN ILE VAL GLY          
SEQRES  13 A  390  LEU MET ILE ASN ALA ILE MET LEU GLY CYS ILE PHE MET          
SEQRES  14 A  390  LYS THR ALA GLN ALA HIS ARG ARG ALA GLU THR LEU ILE          
SEQRES  15 A  390  PHE SER LYS HIS ALA VAL ILE THR LEU ARG HIS GLY ARG          
SEQRES  16 A  390  LEU CYS PHE MET LEU ARG VAL GLY ASP LEU ARG LYS SER          
SEQRES  17 A  390  MET ILE ILE SER ALA THR ILE HIS MET GLN VAL VAL ARG          
SEQRES  18 A  390  LYS THR THR SER PRO GLU GLY GLU VAL VAL PRO LEU HIS          
SEQRES  19 A  390  GLN VAL ASP ILE PRO MET GLU ASN GLY VAL GLY GLY ASN          
SEQRES  20 A  390  GLY ILE PHE LEU VAL ALA PRO LEU ILE ILE TYR HIS VAL          
SEQRES  21 A  390  ILE ASP SER ASN SER PRO LEU TYR ASP LEU ALA PRO SER          
SEQRES  22 A  390  ASP LEU HIS HIS HIS GLN ASP LEU GLU ILE ILE VAL ILE          
SEQRES  23 A  390  LEU GLU GLY VAL VAL GLU THR THR GLY ILE THR THR GLN          
SEQRES  24 A  390  ALA ARG THR SER TYR LEU ALA ASP GLU ILE LEU TRP GLY          
SEQRES  25 A  390  GLN ARG PHE VAL PRO ILE VAL ALA GLU GLU ASP GLY ARG          
SEQRES  26 A  390  TYR SER VAL ASP TYR SER LYS PHE GLY ASN THR ILE LYS          
SEQRES  27 A  390  VAL PRO THR PRO LEU CYS THR ALA ARG GLN LEU ASP GLU          
SEQRES  28 A  390  ASP ARG SER LEU LEU ASP ALA LEU THR LEU ALA SER SER          
SEQRES  29 A  390  ARG GLY PRO LEU ARG LYS ARG SER VAL ALA VAL ALA LYS          
SEQRES  30 A  390  ALA LYS PRO LYS PHE SER ILE SER PRO ASP SER LEU SER          
SEQRES   1 B 1582  MET PRO LEU ALA PHE CYS GLY THR GLU ASN HIS SER ALA          
SEQRES   2 B 1582  ALA TYR ARG VAL ASP GLN GLY VAL LEU ASN ASN GLY CYS          
SEQRES   3 B 1582  PHE VAL ASP ALA LEU ASN VAL VAL PRO HIS VAL PHE LEU          
SEQRES   4 B 1582  LEU PHE ILE THR PHE PRO ILE LEU PHE ILE GLY TRP GLY          
SEQRES   5 B 1582  SER GLN SER SER LYS VAL HIS ILE HIS HIS SER THR TRP          
SEQRES   6 B 1582  LEU HIS PHE PRO GLY HIS ASN LEU ARG TRP ILE LEU THR          
SEQRES   7 B 1582  PHE ILE LEU LEU PHE VAL LEU VAL CYS GLU ILE ALA GLU          
SEQRES   8 B 1582  GLY ILE LEU SER ASP GLY VAL THR GLU SER ARG HIS LEU          
SEQRES   9 B 1582  HIS LEU TYR MET PRO ALA GLY MET ALA PHE MET ALA ALA          
SEQRES  10 B 1582  ILE THR SER VAL VAL TYR TYR HIS ASN ILE GLU THR SER          
SEQRES  11 B 1582  ASN PHE PRO LYS LEU LEU ILE ALA LEU LEU ILE TYR TRP          
SEQRES  12 B 1582  THR LEU ALA PHE ILE THR LYS THR ILE LYS PHE VAL LYS          
SEQRES  13 B 1582  PHE TYR ASP HIS ALA ILE GLY PHE SER GLN LEU ARG PHE          
SEQRES  14 B 1582  CYS LEU THR GLY LEU LEU VAL ILE LEU TYR GLY MET LEU          
SEQRES  15 B 1582  LEU LEU VAL GLU VAL ASN VAL ILE ARG VAL ARG ARG TYR          
SEQRES  16 B 1582  ILE PHE PHE LYS THR PRO ARG GLU VAL LYS PRO PRO GLU          
SEQRES  17 B 1582  ASP LEU GLN ASP LEU GLY VAL ARG PHE LEU GLN PRO PHE          
SEQRES  18 B 1582  VAL ASN LEU LEU SER LYS GLY THR TYR TRP TRP MET ASN          
SEQRES  19 B 1582  ALA PHE ILE LYS THR ALA HIS LYS LYS PRO ILE ASP LEU          
SEQRES  20 B 1582  ARG ALA ILE GLY LYS LEU PRO ILE ALA MET ARG ALA LEU          
SEQRES  21 B 1582  THR ASN TYR GLN ARG LEU CYS VAL ALA PHE ASP ALA GLN          
SEQRES  22 B 1582  ALA ARG LYS ASP THR GLN SER PRO GLN GLY ALA ARG ALA          
SEQRES  23 B 1582  ILE TRP ARG ALA LEU CYS HIS ALA PHE GLY ARG ARG LEU          
SEQRES  24 B 1582  ILE LEU SER SER THR PHE ARG ILE LEU ALA ASP LEU LEU          
SEQRES  25 B 1582  GLY PHE ALA GLY PRO LEU CYS ILE PHE GLY ILE VAL ASP          
SEQRES  26 B 1582  HIS LEU GLY LYS GLU ASN HIS VAL PHE GLN PRO LYS THR          
SEQRES  27 B 1582  GLN PHE LEU GLY VAL TYR PHE VAL SER SER GLN GLU PHE          
SEQRES  28 B 1582  LEU GLY ASN ALA TYR VAL LEU ALA VAL LEU LEU PHE LEU          
SEQRES  29 B 1582  ALA LEU LEU LEU GLN ARG THR PHE LEU GLN ALA SER TYR          
SEQRES  30 B 1582  TYR VAL ALA ILE GLU THR GLY ILE ASN LEU ARG GLY ALA          
SEQRES  31 B 1582  ILE GLN THR LYS ILE TYR ASN LYS ILE MET HIS LEU SER          
SEQRES  32 B 1582  THR SER ASN LEU SER MET GLY GLU MET THR ALA GLY GLN          
SEQRES  33 B 1582  ILE CYS ASN LEU VAL ALA ILE ASP THR ASN GLN LEU MET          
SEQRES  34 B 1582  TRP PHE PHE PHE LEU CYS PRO ASN LEU TRP ALA MET PRO          
SEQRES  35 B 1582  VAL GLN ILE ILE VAL GLY VAL ILE LEU LEU TYR TYR ILE          
SEQRES  36 B 1582  LEU GLY VAL SER ALA LEU ILE GLY ALA ALA VAL ILE ILE          
SEQRES  37 B 1582  LEU LEU ALA PRO VAL GLN TYR PHE VAL ALA THR LYS LEU          
SEQRES  38 B 1582  SER GLN ALA GLN ARG SER THR LEU GLU HIS SER ASN GLU          
SEQRES  39 B 1582  ARG LEU LYS GLN THR ASN GLU MET LEU ARG GLY MET LYS          
SEQRES  40 B 1582  LEU LEU LYS LEU TYR ALA TRP GLU SER ILE PHE CYS SER          
SEQRES  41 B 1582  ARG VAL GLU VAL THR ARG ARG LYS GLU MET THR SER LEU          
SEQRES  42 B 1582  ARG ALA PHE ALA VAL TYR THR SER ILE SER ILE PHE MET          
SEQRES  43 B 1582  ASN THR ALA ILE PRO ILE ALA ALA VAL LEU ILE THR PHE          
SEQRES  44 B 1582  VAL GLY HIS VAL SER PHE PHE LYS GLU SER ASP LEU SER          
SEQRES  45 B 1582  PRO SER VAL ALA PHE ALA SER LEU SER LEU PHE HIS ILE          
SEQRES  46 B 1582  LEU VAL THR PRO LEU PHE LEU LEU SER SER VAL VAL ARG          
SEQRES  47 B 1582  SER THR VAL LYS ALA LEU VAL SER VAL GLN LYS LEU SER          
SEQRES  48 B 1582  GLU PHE LEU SER SER ALA GLU ILE ARG GLU GLU GLN CYS          
SEQRES  49 B 1582  ALA PRO ARG GLU PRO ALA PRO GLN GLY GLN ALA GLY LYS          
SEQRES  50 B 1582  TYR GLN ALA VAL PRO LEU LYS VAL VAL ASN ARG LYS ARG          
SEQRES  51 B 1582  PRO ALA ARG GLU GLU VAL ARG ASP LEU LEU GLY PRO LEU          
SEQRES  52 B 1582  GLN ARG LEU ALA PRO SER MET ASP GLY ASP ALA ASP ASN          
SEQRES  53 B 1582  PHE CYS VAL GLN ILE ILE GLY GLY PHE PHE THR TRP THR          
SEQRES  54 B 1582  PRO ASP GLY ILE PRO THR LEU SER ASN ILE THR ILE ARG          
SEQRES  55 B 1582  ILE PRO ARG GLY GLN LEU THR MET ILE VAL GLY GLN VAL          
SEQRES  56 B 1582  GLY CYS GLY LYS SER SER LEU LEU LEU ALA THR LEU GLY          
SEQRES  57 B 1582  GLU MET GLN LYS VAL SER GLY ALA VAL PHE TRP ASN SER          
SEQRES  58 B 1582  ASN LEU PRO ASP SER GLU GLY GLU ASP PRO SER SER PRO          
SEQRES  59 B 1582  GLU ARG GLU THR ALA ALA GLY SER ASP ILE ARG SER ARG          
SEQRES  60 B 1582  GLY PRO VAL ALA TYR ALA SER GLN LYS PRO TRP LEU LEU          
SEQRES  61 B 1582  ASN ALA THR VAL GLU GLU ASN ILE THR PHE GLU SER PRO          
SEQRES  62 B 1582  PHE ASN LYS GLN ARG TYR LYS MET VAL ILE GLU ALA CYS          
SEQRES  63 B 1582  SER LEU GLN PRO ASP ILE ASP ILE LEU PRO HIS GLY ASP          
SEQRES  64 B 1582  GLN THR GLN ILE GLY GLU ARG GLY ILE ASN LEU SER GLY          
SEQRES  65 B 1582  GLY GLN ARG GLN ARG ILE SER VAL ALA ARG ALA LEU TYR          
SEQRES  66 B 1582  GLN GLN THR ASN VAL VAL PHE LEU ASP ASP PRO PHE SER          
SEQRES  67 B 1582  ALA LEU ASP VAL HIS LEU SER ASP HIS LEU MET GLN ALA          
SEQRES  68 B 1582  GLY ILE LEU GLU LEU LEU ARG ASP ASP LYS ARG THR VAL          
SEQRES  69 B 1582  VAL LEU VAL THR HIS LYS LEU GLN TYR LEU PRO HIS ALA          
SEQRES  70 B 1582  ASP TRP ILE ILE ALA MET LYS ASP GLY THR ILE GLN ARG          
SEQRES  71 B 1582  GLU GLY THR LEU LYS ASP PHE GLN ARG SER GLU CYS GLN          
SEQRES  72 B 1582  LEU PHE GLU HIS TRP LYS THR LEU MET ASN ARG GLN ASP          
SEQRES  73 B 1582  GLN GLU LEU GLU LYS GLU THR VAL MET GLU ARG LYS ALA          
SEQRES  74 B 1582  SER GLU PRO SER GLN GLY LEU PRO ARG ALA MET SER SER          
SEQRES  75 B 1582  ARG ASP GLY LEU LEU LEU ASP GLU GLU GLU GLU GLU GLU          
SEQRES  76 B 1582  GLU ALA ALA GLU SER GLU GLU ASP ASP ASN LEU SER SER          
SEQRES  77 B 1582  VAL LEU HIS GLN ARG ALA LYS ILE PRO TRP ARG ALA CYS          
SEQRES  78 B 1582  THR LYS TYR LEU SER SER ALA GLY ILE LEU LEU LEU SER          
SEQRES  79 B 1582  LEU LEU VAL PHE SER GLN LEU LEU LYS HIS MET VAL LEU          
SEQRES  80 B 1582  VAL ALA ILE ASP TYR TRP LEU ALA LYS TRP THR ASP SER          
SEQRES  81 B 1582  ALA LEU VAL LEU SER PRO ALA ALA ARG ASN CYS SER LEU          
SEQRES  82 B 1582  SER GLN GLU CYS ASP LEU ASP GLN SER VAL TYR ALA MET          
SEQRES  83 B 1582  VAL PHE THR LEU LEU CYS SER LEU GLY ILE VAL LEU CYS          
SEQRES  84 B 1582  LEU VAL THR SER VAL THR VAL GLU TRP THR GLY LEU LYS          
SEQRES  85 B 1582  VAL ALA LYS ARG LEU HIS ARG SER LEU LEU ASN ARG ILE          
SEQRES  86 B 1582  ILE LEU ALA PRO MET ARG PHE PHE GLU THR THR PRO LEU          
SEQRES  87 B 1582  GLY SER ILE LEU ASN ARG PHE SER SER ASP CYS ASN THR          
SEQRES  88 B 1582  ILE ASP GLN HIS ILE PRO SER THR LEU GLU CYS LEU SER          
SEQRES  89 B 1582  ARG SER THR LEU LEU CYS VAL SER ALA LEU THR VAL ILE          
SEQRES  90 B 1582  SER TYR VAL THR PRO VAL PHE LEU VAL ALA LEU LEU PRO          
SEQRES  91 B 1582  LEU ALA VAL VAL CYS TYR PHE ILE GLN LYS TYR PHE ARG          
SEQRES  92 B 1582  VAL ALA SER ARG ASP LEU GLN GLN LEU ASP ASP THR THR          
SEQRES  93 B 1582  GLN LEU PRO LEU LEU SER HIS PHE ALA GLU THR VAL GLU          
SEQRES  94 B 1582  GLY LEU THR THR ILE ARG ALA PHE ARG TYR GLU ALA ARG          
SEQRES  95 B 1582  PHE GLN GLN LYS LEU LEU GLU TYR THR ASP SER ASN ASN          
SEQRES  96 B 1582  ILE ALA SER LEU PHE LEU THR ALA ALA ASN ARG TRP LEU          
SEQRES  97 B 1582  GLU VAL ARG MET GLU TYR ILE GLY ALA CYS VAL VAL LEU          
SEQRES  98 B 1582  ILE ALA ALA ALA THR SER ILE SER ASN SER LEU HIS ARG          
SEQRES  99 B 1582  GLU LEU SER ALA GLY LEU VAL GLY LEU GLY LEU THR TYR          
SEQRES 100 B 1582  ALA LEU MET VAL SER ASN TYR LEU ASN TRP MET VAL ARG          
SEQRES 101 B 1582  ASN LEU ALA ASP MET GLU ILE GLN LEU GLY ALA VAL LYS          
SEQRES 102 B 1582  ARG ILE HIS ALA LEU LEU LYS THR GLU ALA GLU SER TYR          
SEQRES 103 B 1582  GLU GLY LEU LEU ALA PRO SER LEU ILE PRO LYS ASN TRP          
SEQRES 104 B 1582  PRO ASP GLN GLY LYS ILE GLN ILE GLN ASN LEU SER VAL          
SEQRES 105 B 1582  ARG TYR ASP SER SER LEU LYS PRO VAL LEU LYS HIS VAL          
SEQRES 106 B 1582  ASN ALA LEU ILE SER PRO GLY GLN LYS ILE GLY ILE CYS          
SEQRES 107 B 1582  GLY ARG THR GLY SER GLY LYS SER SER PHE SER LEU ALA          
SEQRES 108 B 1582  PHE PHE ARG MET VAL ASP MET PHE GLU GLY ARG ILE ILE          
SEQRES 109 B 1582  ILE ASP GLY ILE ASP ILE ALA LYS LEU PRO LEU HIS THR          
SEQRES 110 B 1582  LEU ARG SER ARG LEU SER ILE ILE LEU GLN ASP PRO VAL          
SEQRES 111 B 1582  LEU PHE SER GLY THR ILE ARG PHE ASN LEU ASP PRO GLU          
SEQRES 112 B 1582  LYS LYS CYS SER ASP SER THR LEU TRP GLU ALA LEU GLU          
SEQRES 113 B 1582  ILE ALA GLN LEU LYS LEU VAL VAL LYS ALA LEU PRO GLY          
SEQRES 114 B 1582  GLY LEU ASP ALA ILE ILE THR GLU GLY GLY GLU ASN PHE          
SEQRES 115 B 1582  SER GLN GLY GLN ARG GLN LEU PHE CYS LEU ALA ARG ALA          
SEQRES 116 B 1582  PHE VAL ARG LYS THR SER ILE PHE ILE MET ASP GLU ALA          
SEQRES 117 B 1582  THR ALA SER ILE ASP MET ALA THR GLU ASN ILE LEU GLN          
SEQRES 118 B 1582  LYS VAL VAL MET THR ALA PHE ALA ASP ARG THR VAL VAL          
SEQRES 119 B 1582  THR ILE ALA HIS ARG VAL HIS THR ILE LEU SER ALA ASP          
SEQRES 120 B 1582  LEU VAL MET VAL LEU LYS ARG GLY ALA ILE LEU GLU PHE          
SEQRES 121 B 1582  ASP LYS PRO GLU THR LEU LEU SER GLN LYS ASP SER VAL          
SEQRES 122 B 1582  PHE ALA SER PHE VAL ARG ALA ASP LYS                          
SEQRES   1 C  390  MET LEU SER ARG LYS GLY ILE ILE PRO GLU GLU TYR VAL          
SEQRES   2 C  390  LEU THR ARG LEU ALA GLU ASP PRO ALA GLU PRO ARG TYR          
SEQRES   3 C  390  ARG THR ARG GLU ARG ARG ALA ARG PHE VAL SER LYS LYS          
SEQRES   4 C  390  GLY ASN CYS ASN VAL ALA HIS LYS ASN ILE ARG GLU GLN          
SEQRES   5 C  390  GLY ARG PHE LEU GLN ASP VAL PHE THR THR LEU VAL ASP          
SEQRES   6 C  390  LEU LYS TRP PRO HIS THR LEU LEU ILE PHE THR MET SER          
SEQRES   7 C  390  PHE LEU CYS SER TRP LEU LEU PHE ALA MET VAL TRP TRP          
SEQRES   8 C  390  LEU ILE ALA PHE ALA HIS GLY ASP LEU ALA PRO GLY GLU          
SEQRES   9 C  390  GLY THR ASN VAL PRO CYS VAL THR SER ILE HIS SER PHE          
SEQRES  10 C  390  SER SER ALA PHE LEU PHE SER ILE GLU VAL GLN VAL THR          
SEQRES  11 C  390  ILE GLY PHE GLY GLY ARG MET VAL THR GLU GLU CYS PRO          
SEQRES  12 C  390  LEU ALA ILE LEU ILE LEU ILE VAL GLN ASN ILE VAL GLY          
SEQRES  13 C  390  LEU MET ILE ASN ALA ILE MET LEU GLY CYS ILE PHE MET          
SEQRES  14 C  390  LYS THR ALA GLN ALA HIS ARG ARG ALA GLU THR LEU ILE          
SEQRES  15 C  390  PHE SER LYS HIS ALA VAL ILE THR LEU ARG HIS GLY ARG          
SEQRES  16 C  390  LEU CYS PHE MET LEU ARG VAL GLY ASP LEU ARG LYS SER          
SEQRES  17 C  390  MET ILE ILE SER ALA THR ILE HIS MET GLN VAL VAL ARG          
SEQRES  18 C  390  LYS THR THR SER PRO GLU GLY GLU VAL VAL PRO LEU HIS          
SEQRES  19 C  390  GLN VAL ASP ILE PRO MET GLU ASN GLY VAL GLY GLY ASN          
SEQRES  20 C  390  GLY ILE PHE LEU VAL ALA PRO LEU ILE ILE TYR HIS VAL          
SEQRES  21 C  390  ILE ASP SER ASN SER PRO LEU TYR ASP LEU ALA PRO SER          
SEQRES  22 C  390  ASP LEU HIS HIS HIS GLN ASP LEU GLU ILE ILE VAL ILE          
SEQRES  23 C  390  LEU GLU GLY VAL VAL GLU THR THR GLY ILE THR THR GLN          
SEQRES  24 C  390  ALA ARG THR SER TYR LEU ALA ASP GLU ILE LEU TRP GLY          
SEQRES  25 C  390  GLN ARG PHE VAL PRO ILE VAL ALA GLU GLU ASP GLY ARG          
SEQRES  26 C  390  TYR SER VAL ASP TYR SER LYS PHE GLY ASN THR ILE LYS          
SEQRES  27 C  390  VAL PRO THR PRO LEU CYS THR ALA ARG GLN LEU ASP GLU          
SEQRES  28 C  390  ASP ARG SER LEU LEU ASP ALA LEU THR LEU ALA SER SER          
SEQRES  29 C  390  ARG GLY PRO LEU ARG LYS ARG SER VAL ALA VAL ALA LYS          
SEQRES  30 C  390  ALA LYS PRO LYS PHE SER ILE SER PRO ASP SER LEU SER          
SEQRES   1 D 1582  MET PRO LEU ALA PHE CYS GLY THR GLU ASN HIS SER ALA          
SEQRES   2 D 1582  ALA TYR ARG VAL ASP GLN GLY VAL LEU ASN ASN GLY CYS          
SEQRES   3 D 1582  PHE VAL ASP ALA LEU ASN VAL VAL PRO HIS VAL PHE LEU          
SEQRES   4 D 1582  LEU PHE ILE THR PHE PRO ILE LEU PHE ILE GLY TRP GLY          
SEQRES   5 D 1582  SER GLN SER SER LYS VAL HIS ILE HIS HIS SER THR TRP          
SEQRES   6 D 1582  LEU HIS PHE PRO GLY HIS ASN LEU ARG TRP ILE LEU THR          
SEQRES   7 D 1582  PHE ILE LEU LEU PHE VAL LEU VAL CYS GLU ILE ALA GLU          
SEQRES   8 D 1582  GLY ILE LEU SER ASP GLY VAL THR GLU SER ARG HIS LEU          
SEQRES   9 D 1582  HIS LEU TYR MET PRO ALA GLY MET ALA PHE MET ALA ALA          
SEQRES  10 D 1582  ILE THR SER VAL VAL TYR TYR HIS ASN ILE GLU THR SER          
SEQRES  11 D 1582  ASN PHE PRO LYS LEU LEU ILE ALA LEU LEU ILE TYR TRP          
SEQRES  12 D 1582  THR LEU ALA PHE ILE THR LYS THR ILE LYS PHE VAL LYS          
SEQRES  13 D 1582  PHE TYR ASP HIS ALA ILE GLY PHE SER GLN LEU ARG PHE          
SEQRES  14 D 1582  CYS LEU THR GLY LEU LEU VAL ILE LEU TYR GLY MET LEU          
SEQRES  15 D 1582  LEU LEU VAL GLU VAL ASN VAL ILE ARG VAL ARG ARG TYR          
SEQRES  16 D 1582  ILE PHE PHE LYS THR PRO ARG GLU VAL LYS PRO PRO GLU          
SEQRES  17 D 1582  ASP LEU GLN ASP LEU GLY VAL ARG PHE LEU GLN PRO PHE          
SEQRES  18 D 1582  VAL ASN LEU LEU SER LYS GLY THR TYR TRP TRP MET ASN          
SEQRES  19 D 1582  ALA PHE ILE LYS THR ALA HIS LYS LYS PRO ILE ASP LEU          
SEQRES  20 D 1582  ARG ALA ILE GLY LYS LEU PRO ILE ALA MET ARG ALA LEU          
SEQRES  21 D 1582  THR ASN TYR GLN ARG LEU CYS VAL ALA PHE ASP ALA GLN          
SEQRES  22 D 1582  ALA ARG LYS ASP THR GLN SER PRO GLN GLY ALA ARG ALA          
SEQRES  23 D 1582  ILE TRP ARG ALA LEU CYS HIS ALA PHE GLY ARG ARG LEU          
SEQRES  24 D 1582  ILE LEU SER SER THR PHE ARG ILE LEU ALA ASP LEU LEU          
SEQRES  25 D 1582  GLY PHE ALA GLY PRO LEU CYS ILE PHE GLY ILE VAL ASP          
SEQRES  26 D 1582  HIS LEU GLY LYS GLU ASN HIS VAL PHE GLN PRO LYS THR          
SEQRES  27 D 1582  GLN PHE LEU GLY VAL TYR PHE VAL SER SER GLN GLU PHE          
SEQRES  28 D 1582  LEU GLY ASN ALA TYR VAL LEU ALA VAL LEU LEU PHE LEU          
SEQRES  29 D 1582  ALA LEU LEU LEU GLN ARG THR PHE LEU GLN ALA SER TYR          
SEQRES  30 D 1582  TYR VAL ALA ILE GLU THR GLY ILE ASN LEU ARG GLY ALA          
SEQRES  31 D 1582  ILE GLN THR LYS ILE TYR ASN LYS ILE MET HIS LEU SER          
SEQRES  32 D 1582  THR SER ASN LEU SER MET GLY GLU MET THR ALA GLY GLN          
SEQRES  33 D 1582  ILE CYS ASN LEU VAL ALA ILE ASP THR ASN GLN LEU MET          
SEQRES  34 D 1582  TRP PHE PHE PHE LEU CYS PRO ASN LEU TRP ALA MET PRO          
SEQRES  35 D 1582  VAL GLN ILE ILE VAL GLY VAL ILE LEU LEU TYR TYR ILE          
SEQRES  36 D 1582  LEU GLY VAL SER ALA LEU ILE GLY ALA ALA VAL ILE ILE          
SEQRES  37 D 1582  LEU LEU ALA PRO VAL GLN TYR PHE VAL ALA THR LYS LEU          
SEQRES  38 D 1582  SER GLN ALA GLN ARG SER THR LEU GLU HIS SER ASN GLU          
SEQRES  39 D 1582  ARG LEU LYS GLN THR ASN GLU MET LEU ARG GLY MET LYS          
SEQRES  40 D 1582  LEU LEU LYS LEU TYR ALA TRP GLU SER ILE PHE CYS SER          
SEQRES  41 D 1582  ARG VAL GLU VAL THR ARG ARG LYS GLU MET THR SER LEU          
SEQRES  42 D 1582  ARG ALA PHE ALA VAL TYR THR SER ILE SER ILE PHE MET          
SEQRES  43 D 1582  ASN THR ALA ILE PRO ILE ALA ALA VAL LEU ILE THR PHE          
SEQRES  44 D 1582  VAL GLY HIS VAL SER PHE PHE LYS GLU SER ASP LEU SER          
SEQRES  45 D 1582  PRO SER VAL ALA PHE ALA SER LEU SER LEU PHE HIS ILE          
SEQRES  46 D 1582  LEU VAL THR PRO LEU PHE LEU LEU SER SER VAL VAL ARG          
SEQRES  47 D 1582  SER THR VAL LYS ALA LEU VAL SER VAL GLN LYS LEU SER          
SEQRES  48 D 1582  GLU PHE LEU SER SER ALA GLU ILE ARG GLU GLU GLN CYS          
SEQRES  49 D 1582  ALA PRO ARG GLU PRO ALA PRO GLN GLY GLN ALA GLY LYS          
SEQRES  50 D 1582  TYR GLN ALA VAL PRO LEU LYS VAL VAL ASN ARG LYS ARG          
SEQRES  51 D 1582  PRO ALA ARG GLU GLU VAL ARG ASP LEU LEU GLY PRO LEU          
SEQRES  52 D 1582  GLN ARG LEU ALA PRO SER MET ASP GLY ASP ALA ASP ASN          
SEQRES  53 D 1582  PHE CYS VAL GLN ILE ILE GLY GLY PHE PHE THR TRP THR          
SEQRES  54 D 1582  PRO ASP GLY ILE PRO THR LEU SER ASN ILE THR ILE ARG          
SEQRES  55 D 1582  ILE PRO ARG GLY GLN LEU THR MET ILE VAL GLY GLN VAL          
SEQRES  56 D 1582  GLY CYS GLY LYS SER SER LEU LEU LEU ALA THR LEU GLY          
SEQRES  57 D 1582  GLU MET GLN LYS VAL SER GLY ALA VAL PHE TRP ASN SER          
SEQRES  58 D 1582  ASN LEU PRO ASP SER GLU GLY GLU ASP PRO SER SER PRO          
SEQRES  59 D 1582  GLU ARG GLU THR ALA ALA GLY SER ASP ILE ARG SER ARG          
SEQRES  60 D 1582  GLY PRO VAL ALA TYR ALA SER GLN LYS PRO TRP LEU LEU          
SEQRES  61 D 1582  ASN ALA THR VAL GLU GLU ASN ILE THR PHE GLU SER PRO          
SEQRES  62 D 1582  PHE ASN LYS GLN ARG TYR LYS MET VAL ILE GLU ALA CYS          
SEQRES  63 D 1582  SER LEU GLN PRO ASP ILE ASP ILE LEU PRO HIS GLY ASP          
SEQRES  64 D 1582  GLN THR GLN ILE GLY GLU ARG GLY ILE ASN LEU SER GLY          
SEQRES  65 D 1582  GLY GLN ARG GLN ARG ILE SER VAL ALA ARG ALA LEU TYR          
SEQRES  66 D 1582  GLN GLN THR ASN VAL VAL PHE LEU ASP ASP PRO PHE SER          
SEQRES  67 D 1582  ALA LEU ASP VAL HIS LEU SER ASP HIS LEU MET GLN ALA          
SEQRES  68 D 1582  GLY ILE LEU GLU LEU LEU ARG ASP ASP LYS ARG THR VAL          
SEQRES  69 D 1582  VAL LEU VAL THR HIS LYS LEU GLN TYR LEU PRO HIS ALA          
SEQRES  70 D 1582  ASP TRP ILE ILE ALA MET LYS ASP GLY THR ILE GLN ARG          
SEQRES  71 D 1582  GLU GLY THR LEU LYS ASP PHE GLN ARG SER GLU CYS GLN          
SEQRES  72 D 1582  LEU PHE GLU HIS TRP LYS THR LEU MET ASN ARG GLN ASP          
SEQRES  73 D 1582  GLN GLU LEU GLU LYS GLU THR VAL MET GLU ARG LYS ALA          
SEQRES  74 D 1582  SER GLU PRO SER GLN GLY LEU PRO ARG ALA MET SER SER          
SEQRES  75 D 1582  ARG ASP GLY LEU LEU LEU ASP GLU GLU GLU GLU GLU GLU          
SEQRES  76 D 1582  GLU ALA ALA GLU SER GLU GLU ASP ASP ASN LEU SER SER          
SEQRES  77 D 1582  VAL LEU HIS GLN ARG ALA LYS ILE PRO TRP ARG ALA CYS          
SEQRES  78 D 1582  THR LYS TYR LEU SER SER ALA GLY ILE LEU LEU LEU SER          
SEQRES  79 D 1582  LEU LEU VAL PHE SER GLN LEU LEU LYS HIS MET VAL LEU          
SEQRES  80 D 1582  VAL ALA ILE ASP TYR TRP LEU ALA LYS TRP THR ASP SER          
SEQRES  81 D 1582  ALA LEU VAL LEU SER PRO ALA ALA ARG ASN CYS SER LEU          
SEQRES  82 D 1582  SER GLN GLU CYS ASP LEU ASP GLN SER VAL TYR ALA MET          
SEQRES  83 D 1582  VAL PHE THR LEU LEU CYS SER LEU GLY ILE VAL LEU CYS          
SEQRES  84 D 1582  LEU VAL THR SER VAL THR VAL GLU TRP THR GLY LEU LYS          
SEQRES  85 D 1582  VAL ALA LYS ARG LEU HIS ARG SER LEU LEU ASN ARG ILE          
SEQRES  86 D 1582  ILE LEU ALA PRO MET ARG PHE PHE GLU THR THR PRO LEU          
SEQRES  87 D 1582  GLY SER ILE LEU ASN ARG PHE SER SER ASP CYS ASN THR          
SEQRES  88 D 1582  ILE ASP GLN HIS ILE PRO SER THR LEU GLU CYS LEU SER          
SEQRES  89 D 1582  ARG SER THR LEU LEU CYS VAL SER ALA LEU THR VAL ILE          
SEQRES  90 D 1582  SER TYR VAL THR PRO VAL PHE LEU VAL ALA LEU LEU PRO          
SEQRES  91 D 1582  LEU ALA VAL VAL CYS TYR PHE ILE GLN LYS TYR PHE ARG          
SEQRES  92 D 1582  VAL ALA SER ARG ASP LEU GLN GLN LEU ASP ASP THR THR          
SEQRES  93 D 1582  GLN LEU PRO LEU LEU SER HIS PHE ALA GLU THR VAL GLU          
SEQRES  94 D 1582  GLY LEU THR THR ILE ARG ALA PHE ARG TYR GLU ALA ARG          
SEQRES  95 D 1582  PHE GLN GLN LYS LEU LEU GLU TYR THR ASP SER ASN ASN          
SEQRES  96 D 1582  ILE ALA SER LEU PHE LEU THR ALA ALA ASN ARG TRP LEU          
SEQRES  97 D 1582  GLU VAL ARG MET GLU TYR ILE GLY ALA CYS VAL VAL LEU          
SEQRES  98 D 1582  ILE ALA ALA ALA THR SER ILE SER ASN SER LEU HIS ARG          
SEQRES  99 D 1582  GLU LEU SER ALA GLY LEU VAL GLY LEU GLY LEU THR TYR          
SEQRES 100 D 1582  ALA LEU MET VAL SER ASN TYR LEU ASN TRP MET VAL ARG          
SEQRES 101 D 1582  ASN LEU ALA ASP MET GLU ILE GLN LEU GLY ALA VAL LYS          
SEQRES 102 D 1582  ARG ILE HIS ALA LEU LEU LYS THR GLU ALA GLU SER TYR          
SEQRES 103 D 1582  GLU GLY LEU LEU ALA PRO SER LEU ILE PRO LYS ASN TRP          
SEQRES 104 D 1582  PRO ASP GLN GLY LYS ILE GLN ILE GLN ASN LEU SER VAL          
SEQRES 105 D 1582  ARG TYR ASP SER SER LEU LYS PRO VAL LEU LYS HIS VAL          
SEQRES 106 D 1582  ASN ALA LEU ILE SER PRO GLY GLN LYS ILE GLY ILE CYS          
SEQRES 107 D 1582  GLY ARG THR GLY SER GLY LYS SER SER PHE SER LEU ALA          
SEQRES 108 D 1582  PHE PHE ARG MET VAL ASP MET PHE GLU GLY ARG ILE ILE          
SEQRES 109 D 1582  ILE ASP GLY ILE ASP ILE ALA LYS LEU PRO LEU HIS THR          
SEQRES 110 D 1582  LEU ARG SER ARG LEU SER ILE ILE LEU GLN ASP PRO VAL          
SEQRES 111 D 1582  LEU PHE SER GLY THR ILE ARG PHE ASN LEU ASP PRO GLU          
SEQRES 112 D 1582  LYS LYS CYS SER ASP SER THR LEU TRP GLU ALA LEU GLU          
SEQRES 113 D 1582  ILE ALA GLN LEU LYS LEU VAL VAL LYS ALA LEU PRO GLY          
SEQRES 114 D 1582  GLY LEU ASP ALA ILE ILE THR GLU GLY GLY GLU ASN PHE          
SEQRES 115 D 1582  SER GLN GLY GLN ARG GLN LEU PHE CYS LEU ALA ARG ALA          
SEQRES 116 D 1582  PHE VAL ARG LYS THR SER ILE PHE ILE MET ASP GLU ALA          
SEQRES 117 D 1582  THR ALA SER ILE ASP MET ALA THR GLU ASN ILE LEU GLN          
SEQRES 118 D 1582  LYS VAL VAL MET THR ALA PHE ALA ASP ARG THR VAL VAL          
SEQRES 119 D 1582  THR ILE ALA HIS ARG VAL HIS THR ILE LEU SER ALA ASP          
SEQRES 120 D 1582  LEU VAL MET VAL LEU LYS ARG GLY ALA ILE LEU GLU PHE          
SEQRES 121 D 1582  ASP LYS PRO GLU THR LEU LEU SER GLN LYS ASP SER VAL          
SEQRES 122 D 1582  PHE ALA SER PHE VAL ARG ALA ASP LYS                          
SEQRES   1 E  390  MET LEU SER ARG LYS GLY ILE ILE PRO GLU GLU TYR VAL          
SEQRES   2 E  390  LEU THR ARG LEU ALA GLU ASP PRO ALA GLU PRO ARG TYR          
SEQRES   3 E  390  ARG THR ARG GLU ARG ARG ALA ARG PHE VAL SER LYS LYS          
SEQRES   4 E  390  GLY ASN CYS ASN VAL ALA HIS LYS ASN ILE ARG GLU GLN          
SEQRES   5 E  390  GLY ARG PHE LEU GLN ASP VAL PHE THR THR LEU VAL ASP          
SEQRES   6 E  390  LEU LYS TRP PRO HIS THR LEU LEU ILE PHE THR MET SER          
SEQRES   7 E  390  PHE LEU CYS SER TRP LEU LEU PHE ALA MET VAL TRP TRP          
SEQRES   8 E  390  LEU ILE ALA PHE ALA HIS GLY ASP LEU ALA PRO GLY GLU          
SEQRES   9 E  390  GLY THR ASN VAL PRO CYS VAL THR SER ILE HIS SER PHE          
SEQRES  10 E  390  SER SER ALA PHE LEU PHE SER ILE GLU VAL GLN VAL THR          
SEQRES  11 E  390  ILE GLY PHE GLY GLY ARG MET VAL THR GLU GLU CYS PRO          
SEQRES  12 E  390  LEU ALA ILE LEU ILE LEU ILE VAL GLN ASN ILE VAL GLY          
SEQRES  13 E  390  LEU MET ILE ASN ALA ILE MET LEU GLY CYS ILE PHE MET          
SEQRES  14 E  390  LYS THR ALA GLN ALA HIS ARG ARG ALA GLU THR LEU ILE          
SEQRES  15 E  390  PHE SER LYS HIS ALA VAL ILE THR LEU ARG HIS GLY ARG          
SEQRES  16 E  390  LEU CYS PHE MET LEU ARG VAL GLY ASP LEU ARG LYS SER          
SEQRES  17 E  390  MET ILE ILE SER ALA THR ILE HIS MET GLN VAL VAL ARG          
SEQRES  18 E  390  LYS THR THR SER PRO GLU GLY GLU VAL VAL PRO LEU HIS          
SEQRES  19 E  390  GLN VAL ASP ILE PRO MET GLU ASN GLY VAL GLY GLY ASN          
SEQRES  20 E  390  GLY ILE PHE LEU VAL ALA PRO LEU ILE ILE TYR HIS VAL          
SEQRES  21 E  390  ILE ASP SER ASN SER PRO LEU TYR ASP LEU ALA PRO SER          
SEQRES  22 E  390  ASP LEU HIS HIS HIS GLN ASP LEU GLU ILE ILE VAL ILE          
SEQRES  23 E  390  LEU GLU GLY VAL VAL GLU THR THR GLY ILE THR THR GLN          
SEQRES  24 E  390  ALA ARG THR SER TYR LEU ALA ASP GLU ILE LEU TRP GLY          
SEQRES  25 E  390  GLN ARG PHE VAL PRO ILE VAL ALA GLU GLU ASP GLY ARG          
SEQRES  26 E  390  TYR SER VAL ASP TYR SER LYS PHE GLY ASN THR ILE LYS          
SEQRES  27 E  390  VAL PRO THR PRO LEU CYS THR ALA ARG GLN LEU ASP GLU          
SEQRES  28 E  390  ASP ARG SER LEU LEU ASP ALA LEU THR LEU ALA SER SER          
SEQRES  29 E  390  ARG GLY PRO LEU ARG LYS ARG SER VAL ALA VAL ALA LYS          
SEQRES  30 E  390  ALA LYS PRO LYS PHE SER ILE SER PRO ASP SER LEU SER          
SEQRES   1 F 1582  MET PRO LEU ALA PHE CYS GLY THR GLU ASN HIS SER ALA          
SEQRES   2 F 1582  ALA TYR ARG VAL ASP GLN GLY VAL LEU ASN ASN GLY CYS          
SEQRES   3 F 1582  PHE VAL ASP ALA LEU ASN VAL VAL PRO HIS VAL PHE LEU          
SEQRES   4 F 1582  LEU PHE ILE THR PHE PRO ILE LEU PHE ILE GLY TRP GLY          
SEQRES   5 F 1582  SER GLN SER SER LYS VAL HIS ILE HIS HIS SER THR TRP          
SEQRES   6 F 1582  LEU HIS PHE PRO GLY HIS ASN LEU ARG TRP ILE LEU THR          
SEQRES   7 F 1582  PHE ILE LEU LEU PHE VAL LEU VAL CYS GLU ILE ALA GLU          
SEQRES   8 F 1582  GLY ILE LEU SER ASP GLY VAL THR GLU SER ARG HIS LEU          
SEQRES   9 F 1582  HIS LEU TYR MET PRO ALA GLY MET ALA PHE MET ALA ALA          
SEQRES  10 F 1582  ILE THR SER VAL VAL TYR TYR HIS ASN ILE GLU THR SER          
SEQRES  11 F 1582  ASN PHE PRO LYS LEU LEU ILE ALA LEU LEU ILE TYR TRP          
SEQRES  12 F 1582  THR LEU ALA PHE ILE THR LYS THR ILE LYS PHE VAL LYS          
SEQRES  13 F 1582  PHE TYR ASP HIS ALA ILE GLY PHE SER GLN LEU ARG PHE          
SEQRES  14 F 1582  CYS LEU THR GLY LEU LEU VAL ILE LEU TYR GLY MET LEU          
SEQRES  15 F 1582  LEU LEU VAL GLU VAL ASN VAL ILE ARG VAL ARG ARG TYR          
SEQRES  16 F 1582  ILE PHE PHE LYS THR PRO ARG GLU VAL LYS PRO PRO GLU          
SEQRES  17 F 1582  ASP LEU GLN ASP LEU GLY VAL ARG PHE LEU GLN PRO PHE          
SEQRES  18 F 1582  VAL ASN LEU LEU SER LYS GLY THR TYR TRP TRP MET ASN          
SEQRES  19 F 1582  ALA PHE ILE LYS THR ALA HIS LYS LYS PRO ILE ASP LEU          
SEQRES  20 F 1582  ARG ALA ILE GLY LYS LEU PRO ILE ALA MET ARG ALA LEU          
SEQRES  21 F 1582  THR ASN TYR GLN ARG LEU CYS VAL ALA PHE ASP ALA GLN          
SEQRES  22 F 1582  ALA ARG LYS ASP THR GLN SER PRO GLN GLY ALA ARG ALA          
SEQRES  23 F 1582  ILE TRP ARG ALA LEU CYS HIS ALA PHE GLY ARG ARG LEU          
SEQRES  24 F 1582  ILE LEU SER SER THR PHE ARG ILE LEU ALA ASP LEU LEU          
SEQRES  25 F 1582  GLY PHE ALA GLY PRO LEU CYS ILE PHE GLY ILE VAL ASP          
SEQRES  26 F 1582  HIS LEU GLY LYS GLU ASN HIS VAL PHE GLN PRO LYS THR          
SEQRES  27 F 1582  GLN PHE LEU GLY VAL TYR PHE VAL SER SER GLN GLU PHE          
SEQRES  28 F 1582  LEU GLY ASN ALA TYR VAL LEU ALA VAL LEU LEU PHE LEU          
SEQRES  29 F 1582  ALA LEU LEU LEU GLN ARG THR PHE LEU GLN ALA SER TYR          
SEQRES  30 F 1582  TYR VAL ALA ILE GLU THR GLY ILE ASN LEU ARG GLY ALA          
SEQRES  31 F 1582  ILE GLN THR LYS ILE TYR ASN LYS ILE MET HIS LEU SER          
SEQRES  32 F 1582  THR SER ASN LEU SER MET GLY GLU MET THR ALA GLY GLN          
SEQRES  33 F 1582  ILE CYS ASN LEU VAL ALA ILE ASP THR ASN GLN LEU MET          
SEQRES  34 F 1582  TRP PHE PHE PHE LEU CYS PRO ASN LEU TRP ALA MET PRO          
SEQRES  35 F 1582  VAL GLN ILE ILE VAL GLY VAL ILE LEU LEU TYR TYR ILE          
SEQRES  36 F 1582  LEU GLY VAL SER ALA LEU ILE GLY ALA ALA VAL ILE ILE          
SEQRES  37 F 1582  LEU LEU ALA PRO VAL GLN TYR PHE VAL ALA THR LYS LEU          
SEQRES  38 F 1582  SER GLN ALA GLN ARG SER THR LEU GLU HIS SER ASN GLU          
SEQRES  39 F 1582  ARG LEU LYS GLN THR ASN GLU MET LEU ARG GLY MET LYS          
SEQRES  40 F 1582  LEU LEU LYS LEU TYR ALA TRP GLU SER ILE PHE CYS SER          
SEQRES  41 F 1582  ARG VAL GLU VAL THR ARG ARG LYS GLU MET THR SER LEU          
SEQRES  42 F 1582  ARG ALA PHE ALA VAL TYR THR SER ILE SER ILE PHE MET          
SEQRES  43 F 1582  ASN THR ALA ILE PRO ILE ALA ALA VAL LEU ILE THR PHE          
SEQRES  44 F 1582  VAL GLY HIS VAL SER PHE PHE LYS GLU SER ASP LEU SER          
SEQRES  45 F 1582  PRO SER VAL ALA PHE ALA SER LEU SER LEU PHE HIS ILE          
SEQRES  46 F 1582  LEU VAL THR PRO LEU PHE LEU LEU SER SER VAL VAL ARG          
SEQRES  47 F 1582  SER THR VAL LYS ALA LEU VAL SER VAL GLN LYS LEU SER          
SEQRES  48 F 1582  GLU PHE LEU SER SER ALA GLU ILE ARG GLU GLU GLN CYS          
SEQRES  49 F 1582  ALA PRO ARG GLU PRO ALA PRO GLN GLY GLN ALA GLY LYS          
SEQRES  50 F 1582  TYR GLN ALA VAL PRO LEU LYS VAL VAL ASN ARG LYS ARG          
SEQRES  51 F 1582  PRO ALA ARG GLU GLU VAL ARG ASP LEU LEU GLY PRO LEU          
SEQRES  52 F 1582  GLN ARG LEU ALA PRO SER MET ASP GLY ASP ALA ASP ASN          
SEQRES  53 F 1582  PHE CYS VAL GLN ILE ILE GLY GLY PHE PHE THR TRP THR          
SEQRES  54 F 1582  PRO ASP GLY ILE PRO THR LEU SER ASN ILE THR ILE ARG          
SEQRES  55 F 1582  ILE PRO ARG GLY GLN LEU THR MET ILE VAL GLY GLN VAL          
SEQRES  56 F 1582  GLY CYS GLY LYS SER SER LEU LEU LEU ALA THR LEU GLY          
SEQRES  57 F 1582  GLU MET GLN LYS VAL SER GLY ALA VAL PHE TRP ASN SER          
SEQRES  58 F 1582  ASN LEU PRO ASP SER GLU GLY GLU ASP PRO SER SER PRO          
SEQRES  59 F 1582  GLU ARG GLU THR ALA ALA GLY SER ASP ILE ARG SER ARG          
SEQRES  60 F 1582  GLY PRO VAL ALA TYR ALA SER GLN LYS PRO TRP LEU LEU          
SEQRES  61 F 1582  ASN ALA THR VAL GLU GLU ASN ILE THR PHE GLU SER PRO          
SEQRES  62 F 1582  PHE ASN LYS GLN ARG TYR LYS MET VAL ILE GLU ALA CYS          
SEQRES  63 F 1582  SER LEU GLN PRO ASP ILE ASP ILE LEU PRO HIS GLY ASP          
SEQRES  64 F 1582  GLN THR GLN ILE GLY GLU ARG GLY ILE ASN LEU SER GLY          
SEQRES  65 F 1582  GLY GLN ARG GLN ARG ILE SER VAL ALA ARG ALA LEU TYR          
SEQRES  66 F 1582  GLN GLN THR ASN VAL VAL PHE LEU ASP ASP PRO PHE SER          
SEQRES  67 F 1582  ALA LEU ASP VAL HIS LEU SER ASP HIS LEU MET GLN ALA          
SEQRES  68 F 1582  GLY ILE LEU GLU LEU LEU ARG ASP ASP LYS ARG THR VAL          
SEQRES  69 F 1582  VAL LEU VAL THR HIS LYS LEU GLN TYR LEU PRO HIS ALA          
SEQRES  70 F 1582  ASP TRP ILE ILE ALA MET LYS ASP GLY THR ILE GLN ARG          
SEQRES  71 F 1582  GLU GLY THR LEU LYS ASP PHE GLN ARG SER GLU CYS GLN          
SEQRES  72 F 1582  LEU PHE GLU HIS TRP LYS THR LEU MET ASN ARG GLN ASP          
SEQRES  73 F 1582  GLN GLU LEU GLU LYS GLU THR VAL MET GLU ARG LYS ALA          
SEQRES  74 F 1582  SER GLU PRO SER GLN GLY LEU PRO ARG ALA MET SER SER          
SEQRES  75 F 1582  ARG ASP GLY LEU LEU LEU ASP GLU GLU GLU GLU GLU GLU          
SEQRES  76 F 1582  GLU ALA ALA GLU SER GLU GLU ASP ASP ASN LEU SER SER          
SEQRES  77 F 1582  VAL LEU HIS GLN ARG ALA LYS ILE PRO TRP ARG ALA CYS          
SEQRES  78 F 1582  THR LYS TYR LEU SER SER ALA GLY ILE LEU LEU LEU SER          
SEQRES  79 F 1582  LEU LEU VAL PHE SER GLN LEU LEU LYS HIS MET VAL LEU          
SEQRES  80 F 1582  VAL ALA ILE ASP TYR TRP LEU ALA LYS TRP THR ASP SER          
SEQRES  81 F 1582  ALA LEU VAL LEU SER PRO ALA ALA ARG ASN CYS SER LEU          
SEQRES  82 F 1582  SER GLN GLU CYS ASP LEU ASP GLN SER VAL TYR ALA MET          
SEQRES  83 F 1582  VAL PHE THR LEU LEU CYS SER LEU GLY ILE VAL LEU CYS          
SEQRES  84 F 1582  LEU VAL THR SER VAL THR VAL GLU TRP THR GLY LEU LYS          
SEQRES  85 F 1582  VAL ALA LYS ARG LEU HIS ARG SER LEU LEU ASN ARG ILE          
SEQRES  86 F 1582  ILE LEU ALA PRO MET ARG PHE PHE GLU THR THR PRO LEU          
SEQRES  87 F 1582  GLY SER ILE LEU ASN ARG PHE SER SER ASP CYS ASN THR          
SEQRES  88 F 1582  ILE ASP GLN HIS ILE PRO SER THR LEU GLU CYS LEU SER          
SEQRES  89 F 1582  ARG SER THR LEU LEU CYS VAL SER ALA LEU THR VAL ILE          
SEQRES  90 F 1582  SER TYR VAL THR PRO VAL PHE LEU VAL ALA LEU LEU PRO          
SEQRES  91 F 1582  LEU ALA VAL VAL CYS TYR PHE ILE GLN LYS TYR PHE ARG          
SEQRES  92 F 1582  VAL ALA SER ARG ASP LEU GLN GLN LEU ASP ASP THR THR          
SEQRES  93 F 1582  GLN LEU PRO LEU LEU SER HIS PHE ALA GLU THR VAL GLU          
SEQRES  94 F 1582  GLY LEU THR THR ILE ARG ALA PHE ARG TYR GLU ALA ARG          
SEQRES  95 F 1582  PHE GLN GLN LYS LEU LEU GLU TYR THR ASP SER ASN ASN          
SEQRES  96 F 1582  ILE ALA SER LEU PHE LEU THR ALA ALA ASN ARG TRP LEU          
SEQRES  97 F 1582  GLU VAL ARG MET GLU TYR ILE GLY ALA CYS VAL VAL LEU          
SEQRES  98 F 1582  ILE ALA ALA ALA THR SER ILE SER ASN SER LEU HIS ARG          
SEQRES  99 F 1582  GLU LEU SER ALA GLY LEU VAL GLY LEU GLY LEU THR TYR          
SEQRES 100 F 1582  ALA LEU MET VAL SER ASN TYR LEU ASN TRP MET VAL ARG          
SEQRES 101 F 1582  ASN LEU ALA ASP MET GLU ILE GLN LEU GLY ALA VAL LYS          
SEQRES 102 F 1582  ARG ILE HIS ALA LEU LEU LYS THR GLU ALA GLU SER TYR          
SEQRES 103 F 1582  GLU GLY LEU LEU ALA PRO SER LEU ILE PRO LYS ASN TRP          
SEQRES 104 F 1582  PRO ASP GLN GLY LYS ILE GLN ILE GLN ASN LEU SER VAL          
SEQRES 105 F 1582  ARG TYR ASP SER SER LEU LYS PRO VAL LEU LYS HIS VAL          
SEQRES 106 F 1582  ASN ALA LEU ILE SER PRO GLY GLN LYS ILE GLY ILE CYS          
SEQRES 107 F 1582  GLY ARG THR GLY SER GLY LYS SER SER PHE SER LEU ALA          
SEQRES 108 F 1582  PHE PHE ARG MET VAL ASP MET PHE GLU GLY ARG ILE ILE          
SEQRES 109 F 1582  ILE ASP GLY ILE ASP ILE ALA LYS LEU PRO LEU HIS THR          
SEQRES 110 F 1582  LEU ARG SER ARG LEU SER ILE ILE LEU GLN ASP PRO VAL          
SEQRES 111 F 1582  LEU PHE SER GLY THR ILE ARG PHE ASN LEU ASP PRO GLU          
SEQRES 112 F 1582  LYS LYS CYS SER ASP SER THR LEU TRP GLU ALA LEU GLU          
SEQRES 113 F 1582  ILE ALA GLN LEU LYS LEU VAL VAL LYS ALA LEU PRO GLY          
SEQRES 114 F 1582  GLY LEU ASP ALA ILE ILE THR GLU GLY GLY GLU ASN PHE          
SEQRES 115 F 1582  SER GLN GLY GLN ARG GLN LEU PHE CYS LEU ALA ARG ALA          
SEQRES 116 F 1582  PHE VAL ARG LYS THR SER ILE PHE ILE MET ASP GLU ALA          
SEQRES 117 F 1582  THR ALA SER ILE ASP MET ALA THR GLU ASN ILE LEU GLN          
SEQRES 118 F 1582  LYS VAL VAL MET THR ALA PHE ALA ASP ARG THR VAL VAL          
SEQRES 119 F 1582  THR ILE ALA HIS ARG VAL HIS THR ILE LEU SER ALA ASP          
SEQRES 120 F 1582  LEU VAL MET VAL LEU LYS ARG GLY ALA ILE LEU GLU PHE          
SEQRES 121 F 1582  ASP LYS PRO GLU THR LEU LEU SER GLN LYS ASP SER VAL          
SEQRES 122 F 1582  PHE ALA SER PHE VAL ARG ALA ASP LYS                          
SEQRES   1 G  390  MET LEU SER ARG LYS GLY ILE ILE PRO GLU GLU TYR VAL          
SEQRES   2 G  390  LEU THR ARG LEU ALA GLU ASP PRO ALA GLU PRO ARG TYR          
SEQRES   3 G  390  ARG THR ARG GLU ARG ARG ALA ARG PHE VAL SER LYS LYS          
SEQRES   4 G  390  GLY ASN CYS ASN VAL ALA HIS LYS ASN ILE ARG GLU GLN          
SEQRES   5 G  390  GLY ARG PHE LEU GLN ASP VAL PHE THR THR LEU VAL ASP          
SEQRES   6 G  390  LEU LYS TRP PRO HIS THR LEU LEU ILE PHE THR MET SER          
SEQRES   7 G  390  PHE LEU CYS SER TRP LEU LEU PHE ALA MET VAL TRP TRP          
SEQRES   8 G  390  LEU ILE ALA PHE ALA HIS GLY ASP LEU ALA PRO GLY GLU          
SEQRES   9 G  390  GLY THR ASN VAL PRO CYS VAL THR SER ILE HIS SER PHE          
SEQRES  10 G  390  SER SER ALA PHE LEU PHE SER ILE GLU VAL GLN VAL THR          
SEQRES  11 G  390  ILE GLY PHE GLY GLY ARG MET VAL THR GLU GLU CYS PRO          
SEQRES  12 G  390  LEU ALA ILE LEU ILE LEU ILE VAL GLN ASN ILE VAL GLY          
SEQRES  13 G  390  LEU MET ILE ASN ALA ILE MET LEU GLY CYS ILE PHE MET          
SEQRES  14 G  390  LYS THR ALA GLN ALA HIS ARG ARG ALA GLU THR LEU ILE          
SEQRES  15 G  390  PHE SER LYS HIS ALA VAL ILE THR LEU ARG HIS GLY ARG          
SEQRES  16 G  390  LEU CYS PHE MET LEU ARG VAL GLY ASP LEU ARG LYS SER          
SEQRES  17 G  390  MET ILE ILE SER ALA THR ILE HIS MET GLN VAL VAL ARG          
SEQRES  18 G  390  LYS THR THR SER PRO GLU GLY GLU VAL VAL PRO LEU HIS          
SEQRES  19 G  390  GLN VAL ASP ILE PRO MET GLU ASN GLY VAL GLY GLY ASN          
SEQRES  20 G  390  GLY ILE PHE LEU VAL ALA PRO LEU ILE ILE TYR HIS VAL          
SEQRES  21 G  390  ILE ASP SER ASN SER PRO LEU TYR ASP LEU ALA PRO SER          
SEQRES  22 G  390  ASP LEU HIS HIS HIS GLN ASP LEU GLU ILE ILE VAL ILE          
SEQRES  23 G  390  LEU GLU GLY VAL VAL GLU THR THR GLY ILE THR THR GLN          
SEQRES  24 G  390  ALA ARG THR SER TYR LEU ALA ASP GLU ILE LEU TRP GLY          
SEQRES  25 G  390  GLN ARG PHE VAL PRO ILE VAL ALA GLU GLU ASP GLY ARG          
SEQRES  26 G  390  TYR SER VAL ASP TYR SER LYS PHE GLY ASN THR ILE LYS          
SEQRES  27 G  390  VAL PRO THR PRO LEU CYS THR ALA ARG GLN LEU ASP GLU          
SEQRES  28 G  390  ASP ARG SER LEU LEU ASP ALA LEU THR LEU ALA SER SER          
SEQRES  29 G  390  ARG GLY PRO LEU ARG LYS ARG SER VAL ALA VAL ALA LYS          
SEQRES  30 G  390  ALA LYS PRO LYS PHE SER ILE SER PRO ASP SER LEU SER          
SEQRES   1 H 1582  MET PRO LEU ALA PHE CYS GLY THR GLU ASN HIS SER ALA          
SEQRES   2 H 1582  ALA TYR ARG VAL ASP GLN GLY VAL LEU ASN ASN GLY CYS          
SEQRES   3 H 1582  PHE VAL ASP ALA LEU ASN VAL VAL PRO HIS VAL PHE LEU          
SEQRES   4 H 1582  LEU PHE ILE THR PHE PRO ILE LEU PHE ILE GLY TRP GLY          
SEQRES   5 H 1582  SER GLN SER SER LYS VAL HIS ILE HIS HIS SER THR TRP          
SEQRES   6 H 1582  LEU HIS PHE PRO GLY HIS ASN LEU ARG TRP ILE LEU THR          
SEQRES   7 H 1582  PHE ILE LEU LEU PHE VAL LEU VAL CYS GLU ILE ALA GLU          
SEQRES   8 H 1582  GLY ILE LEU SER ASP GLY VAL THR GLU SER ARG HIS LEU          
SEQRES   9 H 1582  HIS LEU TYR MET PRO ALA GLY MET ALA PHE MET ALA ALA          
SEQRES  10 H 1582  ILE THR SER VAL VAL TYR TYR HIS ASN ILE GLU THR SER          
SEQRES  11 H 1582  ASN PHE PRO LYS LEU LEU ILE ALA LEU LEU ILE TYR TRP          
SEQRES  12 H 1582  THR LEU ALA PHE ILE THR LYS THR ILE LYS PHE VAL LYS          
SEQRES  13 H 1582  PHE TYR ASP HIS ALA ILE GLY PHE SER GLN LEU ARG PHE          
SEQRES  14 H 1582  CYS LEU THR GLY LEU LEU VAL ILE LEU TYR GLY MET LEU          
SEQRES  15 H 1582  LEU LEU VAL GLU VAL ASN VAL ILE ARG VAL ARG ARG TYR          
SEQRES  16 H 1582  ILE PHE PHE LYS THR PRO ARG GLU VAL LYS PRO PRO GLU          
SEQRES  17 H 1582  ASP LEU GLN ASP LEU GLY VAL ARG PHE LEU GLN PRO PHE          
SEQRES  18 H 1582  VAL ASN LEU LEU SER LYS GLY THR TYR TRP TRP MET ASN          
SEQRES  19 H 1582  ALA PHE ILE LYS THR ALA HIS LYS LYS PRO ILE ASP LEU          
SEQRES  20 H 1582  ARG ALA ILE GLY LYS LEU PRO ILE ALA MET ARG ALA LEU          
SEQRES  21 H 1582  THR ASN TYR GLN ARG LEU CYS VAL ALA PHE ASP ALA GLN          
SEQRES  22 H 1582  ALA ARG LYS ASP THR GLN SER PRO GLN GLY ALA ARG ALA          
SEQRES  23 H 1582  ILE TRP ARG ALA LEU CYS HIS ALA PHE GLY ARG ARG LEU          
SEQRES  24 H 1582  ILE LEU SER SER THR PHE ARG ILE LEU ALA ASP LEU LEU          
SEQRES  25 H 1582  GLY PHE ALA GLY PRO LEU CYS ILE PHE GLY ILE VAL ASP          
SEQRES  26 H 1582  HIS LEU GLY LYS GLU ASN HIS VAL PHE GLN PRO LYS THR          
SEQRES  27 H 1582  GLN PHE LEU GLY VAL TYR PHE VAL SER SER GLN GLU PHE          
SEQRES  28 H 1582  LEU GLY ASN ALA TYR VAL LEU ALA VAL LEU LEU PHE LEU          
SEQRES  29 H 1582  ALA LEU LEU LEU GLN ARG THR PHE LEU GLN ALA SER TYR          
SEQRES  30 H 1582  TYR VAL ALA ILE GLU THR GLY ILE ASN LEU ARG GLY ALA          
SEQRES  31 H 1582  ILE GLN THR LYS ILE TYR ASN LYS ILE MET HIS LEU SER          
SEQRES  32 H 1582  THR SER ASN LEU SER MET GLY GLU MET THR ALA GLY GLN          
SEQRES  33 H 1582  ILE CYS ASN LEU VAL ALA ILE ASP THR ASN GLN LEU MET          
SEQRES  34 H 1582  TRP PHE PHE PHE LEU CYS PRO ASN LEU TRP ALA MET PRO          
SEQRES  35 H 1582  VAL GLN ILE ILE VAL GLY VAL ILE LEU LEU TYR TYR ILE          
SEQRES  36 H 1582  LEU GLY VAL SER ALA LEU ILE GLY ALA ALA VAL ILE ILE          
SEQRES  37 H 1582  LEU LEU ALA PRO VAL GLN TYR PHE VAL ALA THR LYS LEU          
SEQRES  38 H 1582  SER GLN ALA GLN ARG SER THR LEU GLU HIS SER ASN GLU          
SEQRES  39 H 1582  ARG LEU LYS GLN THR ASN GLU MET LEU ARG GLY MET LYS          
SEQRES  40 H 1582  LEU LEU LYS LEU TYR ALA TRP GLU SER ILE PHE CYS SER          
SEQRES  41 H 1582  ARG VAL GLU VAL THR ARG ARG LYS GLU MET THR SER LEU          
SEQRES  42 H 1582  ARG ALA PHE ALA VAL TYR THR SER ILE SER ILE PHE MET          
SEQRES  43 H 1582  ASN THR ALA ILE PRO ILE ALA ALA VAL LEU ILE THR PHE          
SEQRES  44 H 1582  VAL GLY HIS VAL SER PHE PHE LYS GLU SER ASP LEU SER          
SEQRES  45 H 1582  PRO SER VAL ALA PHE ALA SER LEU SER LEU PHE HIS ILE          
SEQRES  46 H 1582  LEU VAL THR PRO LEU PHE LEU LEU SER SER VAL VAL ARG          
SEQRES  47 H 1582  SER THR VAL LYS ALA LEU VAL SER VAL GLN LYS LEU SER          
SEQRES  48 H 1582  GLU PHE LEU SER SER ALA GLU ILE ARG GLU GLU GLN CYS          
SEQRES  49 H 1582  ALA PRO ARG GLU PRO ALA PRO GLN GLY GLN ALA GLY LYS          
SEQRES  50 H 1582  TYR GLN ALA VAL PRO LEU LYS VAL VAL ASN ARG LYS ARG          
SEQRES  51 H 1582  PRO ALA ARG GLU GLU VAL ARG ASP LEU LEU GLY PRO LEU          
SEQRES  52 H 1582  GLN ARG LEU ALA PRO SER MET ASP GLY ASP ALA ASP ASN          
SEQRES  53 H 1582  PHE CYS VAL GLN ILE ILE GLY GLY PHE PHE THR TRP THR          
SEQRES  54 H 1582  PRO ASP GLY ILE PRO THR LEU SER ASN ILE THR ILE ARG          
SEQRES  55 H 1582  ILE PRO ARG GLY GLN LEU THR MET ILE VAL GLY GLN VAL          
SEQRES  56 H 1582  GLY CYS GLY LYS SER SER LEU LEU LEU ALA THR LEU GLY          
SEQRES  57 H 1582  GLU MET GLN LYS VAL SER GLY ALA VAL PHE TRP ASN SER          
SEQRES  58 H 1582  ASN LEU PRO ASP SER GLU GLY GLU ASP PRO SER SER PRO          
SEQRES  59 H 1582  GLU ARG GLU THR ALA ALA GLY SER ASP ILE ARG SER ARG          
SEQRES  60 H 1582  GLY PRO VAL ALA TYR ALA SER GLN LYS PRO TRP LEU LEU          
SEQRES  61 H 1582  ASN ALA THR VAL GLU GLU ASN ILE THR PHE GLU SER PRO          
SEQRES  62 H 1582  PHE ASN LYS GLN ARG TYR LYS MET VAL ILE GLU ALA CYS          
SEQRES  63 H 1582  SER LEU GLN PRO ASP ILE ASP ILE LEU PRO HIS GLY ASP          
SEQRES  64 H 1582  GLN THR GLN ILE GLY GLU ARG GLY ILE ASN LEU SER GLY          
SEQRES  65 H 1582  GLY GLN ARG GLN ARG ILE SER VAL ALA ARG ALA LEU TYR          
SEQRES  66 H 1582  GLN GLN THR ASN VAL VAL PHE LEU ASP ASP PRO PHE SER          
SEQRES  67 H 1582  ALA LEU ASP VAL HIS LEU SER ASP HIS LEU MET GLN ALA          
SEQRES  68 H 1582  GLY ILE LEU GLU LEU LEU ARG ASP ASP LYS ARG THR VAL          
SEQRES  69 H 1582  VAL LEU VAL THR HIS LYS LEU GLN TYR LEU PRO HIS ALA          
SEQRES  70 H 1582  ASP TRP ILE ILE ALA MET LYS ASP GLY THR ILE GLN ARG          
SEQRES  71 H 1582  GLU GLY THR LEU LYS ASP PHE GLN ARG SER GLU CYS GLN          
SEQRES  72 H 1582  LEU PHE GLU HIS TRP LYS THR LEU MET ASN ARG GLN ASP          
SEQRES  73 H 1582  GLN GLU LEU GLU LYS GLU THR VAL MET GLU ARG LYS ALA          
SEQRES  74 H 1582  SER GLU PRO SER GLN GLY LEU PRO ARG ALA MET SER SER          
SEQRES  75 H 1582  ARG ASP GLY LEU LEU LEU ASP GLU GLU GLU GLU GLU GLU          
SEQRES  76 H 1582  GLU ALA ALA GLU SER GLU GLU ASP ASP ASN LEU SER SER          
SEQRES  77 H 1582  VAL LEU HIS GLN ARG ALA LYS ILE PRO TRP ARG ALA CYS          
SEQRES  78 H 1582  THR LYS TYR LEU SER SER ALA GLY ILE LEU LEU LEU SER          
SEQRES  79 H 1582  LEU LEU VAL PHE SER GLN LEU LEU LYS HIS MET VAL LEU          
SEQRES  80 H 1582  VAL ALA ILE ASP TYR TRP LEU ALA LYS TRP THR ASP SER          
SEQRES  81 H 1582  ALA LEU VAL LEU SER PRO ALA ALA ARG ASN CYS SER LEU          
SEQRES  82 H 1582  SER GLN GLU CYS ASP LEU ASP GLN SER VAL TYR ALA MET          
SEQRES  83 H 1582  VAL PHE THR LEU LEU CYS SER LEU GLY ILE VAL LEU CYS          
SEQRES  84 H 1582  LEU VAL THR SER VAL THR VAL GLU TRP THR GLY LEU LYS          
SEQRES  85 H 1582  VAL ALA LYS ARG LEU HIS ARG SER LEU LEU ASN ARG ILE          
SEQRES  86 H 1582  ILE LEU ALA PRO MET ARG PHE PHE GLU THR THR PRO LEU          
SEQRES  87 H 1582  GLY SER ILE LEU ASN ARG PHE SER SER ASP CYS ASN THR          
SEQRES  88 H 1582  ILE ASP GLN HIS ILE PRO SER THR LEU GLU CYS LEU SER          
SEQRES  89 H 1582  ARG SER THR LEU LEU CYS VAL SER ALA LEU THR VAL ILE          
SEQRES  90 H 1582  SER TYR VAL THR PRO VAL PHE LEU VAL ALA LEU LEU PRO          
SEQRES  91 H 1582  LEU ALA VAL VAL CYS TYR PHE ILE GLN LYS TYR PHE ARG          
SEQRES  92 H 1582  VAL ALA SER ARG ASP LEU GLN GLN LEU ASP ASP THR THR          
SEQRES  93 H 1582  GLN LEU PRO LEU LEU SER HIS PHE ALA GLU THR VAL GLU          
SEQRES  94 H 1582  GLY LEU THR THR ILE ARG ALA PHE ARG TYR GLU ALA ARG          
SEQRES  95 H 1582  PHE GLN GLN LYS LEU LEU GLU TYR THR ASP SER ASN ASN          
SEQRES  96 H 1582  ILE ALA SER LEU PHE LEU THR ALA ALA ASN ARG TRP LEU          
SEQRES  97 H 1582  GLU VAL ARG MET GLU TYR ILE GLY ALA CYS VAL VAL LEU          
SEQRES  98 H 1582  ILE ALA ALA ALA THR SER ILE SER ASN SER LEU HIS ARG          
SEQRES  99 H 1582  GLU LEU SER ALA GLY LEU VAL GLY LEU GLY LEU THR TYR          
SEQRES 100 H 1582  ALA LEU MET VAL SER ASN TYR LEU ASN TRP MET VAL ARG          
SEQRES 101 H 1582  ASN LEU ALA ASP MET GLU ILE GLN LEU GLY ALA VAL LYS          
SEQRES 102 H 1582  ARG ILE HIS ALA LEU LEU LYS THR GLU ALA GLU SER TYR          
SEQRES 103 H 1582  GLU GLY LEU LEU ALA PRO SER LEU ILE PRO LYS ASN TRP          
SEQRES 104 H 1582  PRO ASP GLN GLY LYS ILE GLN ILE GLN ASN LEU SER VAL          
SEQRES 105 H 1582  ARG TYR ASP SER SER LEU LYS PRO VAL LEU LYS HIS VAL          
SEQRES 106 H 1582  ASN ALA LEU ILE SER PRO GLY GLN LYS ILE GLY ILE CYS          
SEQRES 107 H 1582  GLY ARG THR GLY SER GLY LYS SER SER PHE SER LEU ALA          
SEQRES 108 H 1582  PHE PHE ARG MET VAL ASP MET PHE GLU GLY ARG ILE ILE          
SEQRES 109 H 1582  ILE ASP GLY ILE ASP ILE ALA LYS LEU PRO LEU HIS THR          
SEQRES 110 H 1582  LEU ARG SER ARG LEU SER ILE ILE LEU GLN ASP PRO VAL          
SEQRES 111 H 1582  LEU PHE SER GLY THR ILE ARG PHE ASN LEU ASP PRO GLU          
SEQRES 112 H 1582  LYS LYS CYS SER ASP SER THR LEU TRP GLU ALA LEU GLU          
SEQRES 113 H 1582  ILE ALA GLN LEU LYS LEU VAL VAL LYS ALA LEU PRO GLY          
SEQRES 114 H 1582  GLY LEU ASP ALA ILE ILE THR GLU GLY GLY GLU ASN PHE          
SEQRES 115 H 1582  SER GLN GLY GLN ARG GLN LEU PHE CYS LEU ALA ARG ALA          
SEQRES 116 H 1582  PHE VAL ARG LYS THR SER ILE PHE ILE MET ASP GLU ALA          
SEQRES 117 H 1582  THR ALA SER ILE ASP MET ALA THR GLU ASN ILE LEU GLN          
SEQRES 118 H 1582  LYS VAL VAL MET THR ALA PHE ALA ASP ARG THR VAL VAL          
SEQRES 119 H 1582  THR ILE ALA HIS ARG VAL HIS THR ILE LEU SER ALA ASP          
SEQRES 120 H 1582  LEU VAL MET VAL LEU LYS ARG GLY ALA ILE LEU GLU PHE          
SEQRES 121 H 1582  ASP LYS PRO GLU THR LEU LEU SER GLN LYS ASP SER VAL          
SEQRES 122 H 1582  PHE ALA SER PHE VAL ARG ALA ASP LYS                          
HET    AGS  A 401      31                                                       
HET    GBM  B2001      33                                                       
HET    AGS  B2002      31                                                       
HET    AGS  C 401      31                                                       
HET    GBM  D2001      33                                                       
HET    AGS  D2002      31                                                       
HET    AGS  E 401      31                                                       
HET    GBM  F2001      33                                                       
HET    AGS  F2002      31                                                       
HET    AGS  G 401      31                                                       
HET    GBM  H2001      33                                                       
HET    AGS  H2002      31                                                       
HETNAM     AGS PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER                       
HETNAM     GBM 5-CHLORO-N-(2-{4-[(CYCLOHEXYLCARBAMOYL)                          
HETNAM   2 GBM  SULFAMOYL]PHENYL}ETHYL)-2-METHOXYBENZAMIDE                      
HETSYN     AGS ATP-GAMMA-S; ADENOSINE 5'-(3-THIOTRIPHOSPHATE);                  
HETSYN   2 AGS  ADENOSINE 5'-(GAMMA-THIOTRIPHOSPHATE); ADENOSINE-5'-            
HETSYN   3 AGS  DIPHOSPHATE MONOTHIOPHOSPHATE                                   
HETSYN     GBM GLIBENCLAMIDE, GLYBURIDE                                         
FORMUL   9  AGS    8(C10 H16 N5 O12 P3 S)                                       
FORMUL  10  GBM    4(C23 H28 CL N3 O5 S)                                        
HELIX    1 AA1 ASP A   58  ASP A   65  1                                   8    
HELIX    2 AA2 LYS A   67  GLY A   98  1                                  32    
HELIX    3 AA3 SER A  116  VAL A  129  1                                  14    
HELIX    4 AA4 CYS A  142  ALA A  172  1                                  31    
HELIX    5 AA5 SER A  265  LEU A  270  5                                   6    
HELIX    6 AA6 THR A  345  LEU A  356  1                                  12    
HELIX    7 AA7 GLY B   25  GLY B   52  1                                  28    
HELIX    8 AA8 GLY B   70  ASP B   96  1                                  27    
HELIX    9 AA9 HIS B  103  LEU B  106  5                                   4    
HELIX   10 AB1 TYR B  107  SER B  130  1                                  24    
HELIX   11 AB2 LYS B  134  ASP B  159  1                                  26    
HELIX   12 AB3 ARG B  168  ARG B  193  1                                  26    
HELIX   13 AB4 LEU B  225  TYR B  230  1                                   6    
HELIX   14 AB5 TRP B  232  LYS B  243  1                                  12    
HELIX   15 AB6 ARG B  258  ARG B  275  1                                  18    
HELIX   16 AB7 ALA B  284  LYS B  329  1                                  46    
HELIX   17 AB8 ALA B  355  LEU B  402  1                                  48    
HELIX   18 AB9 MET B  412  ILE B  423  1                                  12    
HELIX   19 AC1 ILE B  423  GLY B  457  1                                  35    
HELIX   20 AC2 GLY B  457  LEU B  503  1                                  47    
HELIX   21 AC3 GLY B  505  TYR B  512  1                                   8    
HELIX   22 AC4 TRP B  514  VAL B  560  1                                  47    
HELIX   23 AC5 SER B  572  SER B  615  1                                  44    
HELIX   24 AC6 GLY B  718  LEU B  727  1                                  10    
HELIX   25 AC7 THR B  783  PHE B  790  1                                   8    
HELIX   26 AC8 LYS B  796  CYS B  806  1                                  11    
HELIX   27 AC9 LEU B  808  LEU B  815  1                                   8    
HELIX   28 AD1 SER B  831  GLN B  846  1                                  16    
HELIX   29 AD2 ASP B  861  GLY B  872  1                                  12    
HELIX   30 AD3 TYR B  893  ALA B  897  5                                   5    
HELIX   31 AD4 LEU B  914  ARG B  919  1                                   6    
HELIX   32 AD5 PRO B  997  SER B 1007  1                                  11    
HELIX   33 AD6 GLY B 1009  ASP B 1039  1                                  31    
HELIX   34 AD7 GLN B 1061  LEU B 1107  1                                  47    
HELIX   35 AD8 PRO B 1109  THR B 1116  1                                   8    
HELIX   36 AD9 PRO B 1117  SER B 1127  1                                  11    
HELIX   37 AE1 SER B 1127  THR B 1161  1                                  35    
HELIX   38 AE2 THR B 1161  GLY B 1210  1                                  50    
HELIX   39 AE3 GLY B 1210  ARG B 1218  1                                   9    
HELIX   40 AE4 TYR B 1219  SER B 1271  1                                  53    
HELIX   41 AE5 SER B 1277  LEU B 1289  1                                  13    
HELIX   42 AE6 MET B 1290  LYS B 1320  1                                  31    
HELIX   43 AE7 GLY B 1384  PHE B 1393  1                                  10    
HELIX   44 AE8 PRO B 1414  SER B 1420  1                                   7    
HELIX   45 AE9 THR B 1435  ASP B 1441  1                                   7    
HELIX   46 AF1 SER B 1447  ALA B 1458  1                                  12    
HELIX   47 AF2 LEU B 1460  ALA B 1466  1                                   7    
HELIX   48 AF3 SER B 1483  LYS B 1499  1                                  17    
HELIX   49 AF4 ASP B 1513  PHE B 1528  1                                  16    
HELIX   50 AF5 ARG B 1539  ALA B 1546  1                                   8    
HELIX   51 AF6 LYS B 1562  LYS B 1570  1                                   9    
HELIX   52 AF7 ASP C   58  ASP C   65  1                                   8    
HELIX   53 AF8 LYS C   67  GLY C   98  1                                  32    
HELIX   54 AF9 SER C  116  VAL C  129  1                                  14    
HELIX   55 AG1 CYS C  142  ALA C  172  1                                  31    
HELIX   56 AG2 SER C  265  LEU C  270  5                                   6    
HELIX   57 AG3 THR C  345  LEU C  356  1                                  12    
HELIX   58 AG4 GLY D   25  GLY D   52  1                                  28    
HELIX   59 AG5 GLY D   70  ASP D   96  1                                  27    
HELIX   60 AG6 HIS D  103  LEU D  106  5                                   4    
HELIX   61 AG7 TYR D  107  SER D  130  1                                  24    
HELIX   62 AG8 LYS D  134  ASP D  159  1                                  26    
HELIX   63 AG9 ARG D  168  ARG D  193  1                                  26    
HELIX   64 AH1 LEU D  225  TYR D  230  1                                   6    
HELIX   65 AH2 TRP D  232  LYS D  243  1                                  12    
HELIX   66 AH3 ARG D  258  ARG D  275  1                                  18    
HELIX   67 AH4 ALA D  284  LYS D  329  1                                  46    
HELIX   68 AH5 ALA D  355  LEU D  402  1                                  48    
HELIX   69 AH6 MET D  412  ILE D  423  1                                  12    
HELIX   70 AH7 ILE D  423  GLY D  457  1                                  35    
HELIX   71 AH8 GLY D  457  LEU D  503  1                                  47    
HELIX   72 AH9 GLY D  505  TYR D  512  1                                   8    
HELIX   73 AI1 TRP D  514  VAL D  560  1                                  47    
HELIX   74 AI2 SER D  572  SER D  615  1                                  44    
HELIX   75 AI3 GLY D  718  LEU D  727  1                                  10    
HELIX   76 AI4 THR D  783  PHE D  790  1                                   8    
HELIX   77 AI5 LYS D  796  CYS D  806  1                                  11    
HELIX   78 AI6 LEU D  808  LEU D  815  1                                   8    
HELIX   79 AI7 SER D  831  GLN D  846  1                                  16    
HELIX   80 AI8 ASP D  861  GLY D  872  1                                  12    
HELIX   81 AI9 TYR D  893  ALA D  897  5                                   5    
HELIX   82 AJ1 LEU D  914  ARG D  919  1                                   6    
HELIX   83 AJ2 PRO D  997  SER D 1007  1                                  11    
HELIX   84 AJ3 GLY D 1009  ASP D 1039  1                                  31    
HELIX   85 AJ4 GLN D 1061  LEU D 1107  1                                  47    
HELIX   86 AJ5 PRO D 1109  THR D 1116  1                                   8    
HELIX   87 AJ6 PRO D 1117  SER D 1127  1                                  11    
HELIX   88 AJ7 SER D 1127  THR D 1161  1                                  35    
HELIX   89 AJ8 THR D 1161  GLY D 1210  1                                  50    
HELIX   90 AJ9 GLY D 1210  ARG D 1218  1                                   9    
HELIX   91 AK1 TYR D 1219  SER D 1271  1                                  53    
HELIX   92 AK2 SER D 1277  LEU D 1289  1                                  13    
HELIX   93 AK3 MET D 1290  LYS D 1320  1                                  31    
HELIX   94 AK4 GLY D 1384  PHE D 1393  1                                  10    
HELIX   95 AK5 PRO D 1414  SER D 1420  1                                   7    
HELIX   96 AK6 THR D 1435  ASP D 1441  1                                   7    
HELIX   97 AK7 SER D 1447  ALA D 1458  1                                  12    
HELIX   98 AK8 LEU D 1460  ALA D 1466  1                                   7    
HELIX   99 AK9 SER D 1483  LYS D 1499  1                                  17    
HELIX  100 AL1 ASP D 1513  PHE D 1528  1                                  16    
HELIX  101 AL2 ARG D 1539  ALA D 1546  1                                   8    
HELIX  102 AL3 LYS D 1562  LYS D 1570  1                                   9    
HELIX  103 AL4 ASP E   58  ASP E   65  1                                   8    
HELIX  104 AL5 LYS E   67  GLY E   98  1                                  32    
HELIX  105 AL6 SER E  116  VAL E  129  1                                  14    
HELIX  106 AL7 CYS E  142  ALA E  172  1                                  31    
HELIX  107 AL8 SER E  265  LEU E  270  5                                   6    
HELIX  108 AL9 THR E  345  LEU E  356  1                                  12    
HELIX  109 AM1 GLY F   25  GLY F   52  1                                  28    
HELIX  110 AM2 GLY F   70  ASP F   96  1                                  27    
HELIX  111 AM3 HIS F  103  LEU F  106  5                                   4    
HELIX  112 AM4 TYR F  107  SER F  130  1                                  24    
HELIX  113 AM5 LYS F  134  ASP F  159  1                                  26    
HELIX  114 AM6 ARG F  168  ARG F  193  1                                  26    
HELIX  115 AM7 LEU F  225  TYR F  230  1                                   6    
HELIX  116 AM8 TRP F  232  LYS F  243  1                                  12    
HELIX  117 AM9 ARG F  258  ARG F  275  1                                  18    
HELIX  118 AN1 ALA F  284  LYS F  329  1                                  46    
HELIX  119 AN2 ALA F  355  LEU F  402  1                                  48    
HELIX  120 AN3 MET F  412  ILE F  423  1                                  12    
HELIX  121 AN4 ILE F  423  GLY F  457  1                                  35    
HELIX  122 AN5 GLY F  457  LEU F  503  1                                  47    
HELIX  123 AN6 GLY F  505  TYR F  512  1                                   8    
HELIX  124 AN7 TRP F  514  VAL F  560  1                                  47    
HELIX  125 AN8 SER F  572  SER F  615  1                                  44    
HELIX  126 AN9 GLY F  718  LEU F  727  1                                  10    
HELIX  127 AO1 THR F  783  PHE F  790  1                                   8    
HELIX  128 AO2 LYS F  796  CYS F  806  1                                  11    
HELIX  129 AO3 LEU F  808  LEU F  815  1                                   8    
HELIX  130 AO4 SER F  831  GLN F  846  1                                  16    
HELIX  131 AO5 ASP F  861  GLY F  872  1                                  12    
HELIX  132 AO6 TYR F  893  ALA F  897  5                                   5    
HELIX  133 AO7 LEU F  914  ARG F  919  1                                   6    
HELIX  134 AO8 PRO F  997  SER F 1007  1                                  11    
HELIX  135 AO9 GLY F 1009  ASP F 1039  1                                  31    
HELIX  136 AP1 GLN F 1061  LEU F 1107  1                                  47    
HELIX  137 AP2 PRO F 1109  THR F 1116  1                                   8    
HELIX  138 AP3 PRO F 1117  SER F 1127  1                                  11    
HELIX  139 AP4 SER F 1127  THR F 1161  1                                  35    
HELIX  140 AP5 THR F 1161  GLY F 1210  1                                  50    
HELIX  141 AP6 GLY F 1210  ARG F 1218  1                                   9    
HELIX  142 AP7 TYR F 1219  SER F 1271  1                                  53    
HELIX  143 AP8 SER F 1277  LEU F 1289  1                                  13    
HELIX  144 AP9 MET F 1290  LYS F 1320  1                                  31    
HELIX  145 AQ1 GLY F 1384  PHE F 1393  1                                  10    
HELIX  146 AQ2 PRO F 1414  SER F 1420  1                                   7    
HELIX  147 AQ3 THR F 1435  ASP F 1441  1                                   7    
HELIX  148 AQ4 SER F 1447  ALA F 1458  1                                  12    
HELIX  149 AQ5 LEU F 1460  ALA F 1466  1                                   7    
HELIX  150 AQ6 SER F 1483  LYS F 1499  1                                  17    
HELIX  151 AQ7 ASP F 1513  PHE F 1528  1                                  16    
HELIX  152 AQ8 ARG F 1539  ALA F 1546  1                                   8    
HELIX  153 AQ9 LYS F 1562  LYS F 1570  1                                   9    
HELIX  154 AR1 ASP G   58  ASP G   65  1                                   8    
HELIX  155 AR2 LYS G   67  GLY G   98  1                                  32    
HELIX  156 AR3 SER G  116  VAL G  129  1                                  14    
HELIX  157 AR4 CYS G  142  ALA G  172  1                                  31    
HELIX  158 AR5 SER G  265  LEU G  270  5                                   6    
HELIX  159 AR6 THR G  345  LEU G  356  1                                  12    
HELIX  160 AR7 GLY H   25  GLY H   52  1                                  28    
HELIX  161 AR8 GLY H   70  ASP H   96  1                                  27    
HELIX  162 AR9 HIS H  103  LEU H  106  5                                   4    
HELIX  163 AS1 TYR H  107  SER H  130  1                                  24    
HELIX  164 AS2 LYS H  134  ASP H  159  1                                  26    
HELIX  165 AS3 ARG H  168  ARG H  193  1                                  26    
HELIX  166 AS4 LEU H  225  TYR H  230  1                                   6    
HELIX  167 AS5 TRP H  232  LYS H  243  1                                  12    
HELIX  168 AS6 ARG H  258  ARG H  275  1                                  18    
HELIX  169 AS7 ALA H  284  LYS H  329  1                                  46    
HELIX  170 AS8 ALA H  355  LEU H  402  1                                  48    
HELIX  171 AS9 MET H  412  ILE H  423  1                                  12    
HELIX  172 AT1 ILE H  423  GLY H  457  1                                  35    
HELIX  173 AT2 GLY H  457  LEU H  503  1                                  47    
HELIX  174 AT3 GLY H  505  TYR H  512  1                                   8    
HELIX  175 AT4 TRP H  514  VAL H  560  1                                  47    
HELIX  176 AT5 SER H  572  SER H  615  1                                  44    
HELIX  177 AT6 GLY H  718  LEU H  727  1                                  10    
HELIX  178 AT7 THR H  783  PHE H  790  1                                   8    
HELIX  179 AT8 LYS H  796  CYS H  806  1                                  11    
HELIX  180 AT9 LEU H  808  LEU H  815  1                                   8    
HELIX  181 AU1 SER H  831  GLN H  846  1                                  16    
HELIX  182 AU2 ASP H  861  GLY H  872  1                                  12    
HELIX  183 AU3 TYR H  893  ALA H  897  5                                   5    
HELIX  184 AU4 LEU H  914  ARG H  919  1                                   6    
HELIX  185 AU5 PRO H  997  SER H 1007  1                                  11    
HELIX  186 AU6 GLY H 1009  ASP H 1039  1                                  31    
HELIX  187 AU7 GLN H 1061  LEU H 1107  1                                  47    
HELIX  188 AU8 PRO H 1109  THR H 1116  1                                   8    
HELIX  189 AU9 PRO H 1117  SER H 1127  1                                  11    
HELIX  190 AV1 SER H 1127  THR H 1161  1                                  35    
HELIX  191 AV2 THR H 1161  GLY H 1210  1                                  50    
HELIX  192 AV3 GLY H 1210  ARG H 1218  1                                   9    
HELIX  193 AV4 TYR H 1219  SER H 1271  1                                  53    
HELIX  194 AV5 SER H 1277  LEU H 1289  1                                  13    
HELIX  195 AV6 MET H 1290  LYS H 1320  1                                  31    
HELIX  196 AV7 GLY H 1384  PHE H 1393  1                                  10    
HELIX  197 AV8 PRO H 1414  SER H 1420  1                                   7    
HELIX  198 AV9 THR H 1435  ASP H 1441  1                                   7    
HELIX  199 AW1 SER H 1447  ALA H 1458  1                                  12    
HELIX  200 AW2 LEU H 1460  ALA H 1466  1                                   7    
HELIX  201 AW3 SER H 1483  LYS H 1499  1                                  17    
HELIX  202 AW4 ASP H 1513  PHE H 1528  1                                  16    
HELIX  203 AW5 ARG H 1539  ALA H 1546  1                                   8    
HELIX  204 AW6 LYS H 1562  LYS H 1570  1                                   9    
SHEET    1 AA1 3 ALA A  45  LYS A  47  0                                        
SHEET    2 AA1 3 TYR C 326  ASP C 329  1  O  VAL C 328   N  LYS A  47           
SHEET    3 AA1 3 VAL C 319  GLU C 321 -1  N  ALA C 320   O  SER C 327           
SHEET    1 AA2 3 VAL A 188  ARG A 192  0                                        
SHEET    2 AA2 3 ARG A 195  LEU A 200 -1  O  MET A 199   N  VAL A 188           
SHEET    3 AA2 3 ILE A 257  VAL A 260 -1  O  HIS A 259   N  PHE A 198           
SHEET    1 AA3 4 VAL A 236  ILE A 238  0                                        
SHEET    2 AA3 4 ILE A 210  VAL A 220 -1  N  MET A 217   O  ILE A 238           
SHEET    3 AA3 4 GLU A 282  VAL A 291 -1  O  VAL A 290   N  ILE A 211           
SHEET    4 AA3 4 THR A 297  TYR A 304 -1  O  ALA A 300   N  LEU A 287           
SHEET    1 AA4 2 THR A 223  THR A 224  0                                        
SHEET    2 AA4 2 VAL A 230  VAL A 231 -1  O  VAL A 231   N  THR A 223           
SHEET    1 AA5 2 GLN A 313  PHE A 315  0                                        
SHEET    2 AA5 2 THR A 336  LYS A 338 -1  O  ILE A 337   N  ARG A 314           
SHEET    1 AA6 3 VAL A 319  GLU A 321  0                                        
SHEET    2 AA6 3 TYR A 326  ASP A 329 -1  O  SER A 327   N  ALA A 320           
SHEET    3 AA6 3 ALA G  45  LYS G  47  1  O  LYS G  47   N  VAL A 328           
SHEET    1 AA7 3 ILE B 701  ILE B 703  0                                        
SHEET    2 AA7 3 VAL B 679  ILE B 682 -1  N  VAL B 679   O  ILE B 703           
SHEET    3 AA7 3 ALA B 736  PHE B 738 -1  O  ALA B 736   N  ILE B 682           
SHEET    1 AA8 2 PHE B 685  PHE B 686  0                                        
SHEET    2 AA8 2 LEU B 696  SER B 697 -1  O  LEU B 696   N  PHE B 686           
SHEET    1 AA9 6 ALA B 771  ALA B 773  0                                        
SHEET    2 AA9 6 VAL B 850  ASP B 854  1  O  ASP B 854   N  ALA B 773           
SHEET    3 AA9 6 THR B 883  VAL B 887  1  O  VAL B 885   N  VAL B 851           
SHEET    4 AA9 6 THR B 709  GLY B 713  1  N  THR B 709   O  VAL B 884           
SHEET    5 AA9 6 TRP B 899  LYS B 904  1  O  ILE B 901   N  VAL B 712           
SHEET    6 AA9 6 THR B 907  THR B 913 -1  O  THR B 907   N  LYS B 904           
SHEET    1 AB1 3 VAL B1365  ILE B1369  0                                        
SHEET    2 AB1 3 ILE B1345  ARG B1353 -1  N  LEU B1350   O  VAL B1365           
SHEET    3 AB1 3 MET B1398  ILE B1405 -1  O  GLU B1400   N  SER B1351           
SHEET    1 AB2 6 SER B1423  ILE B1425  0                                        
SHEET    2 AB2 6 PHE B1503  ASP B1506  1  O  ASP B1506   N  ILE B1425           
SHEET    3 AB2 6 VAL B1533  ILE B1536  1  O  VAL B1534   N  PHE B1503           
SHEET    4 AB2 6 ILE B1375  ILE B1377  1  N  ILE B1375   O  VAL B1533           
SHEET    5 AB2 6 LEU B1548  LEU B1552  1  O  LEU B1548   N  GLY B1376           
SHEET    6 AB2 6 ILE B1557  PHE B1560 -1  O  PHE B1560   N  VAL B1549           
SHEET    1 AB3 3 ALA C  45  LYS C  47  0                                        
SHEET    2 AB3 3 TYR E 326  ASP E 329  1  O  VAL E 328   N  LYS C  47           
SHEET    3 AB3 3 VAL E 319  GLU E 321 -1  N  ALA E 320   O  SER E 327           
SHEET    1 AB4 3 VAL C 188  ARG C 192  0                                        
SHEET    2 AB4 3 ARG C 195  LEU C 200 -1  O  MET C 199   N  VAL C 188           
SHEET    3 AB4 3 ILE C 257  VAL C 260 -1  O  HIS C 259   N  PHE C 198           
SHEET    1 AB5 4 VAL C 236  ILE C 238  0                                        
SHEET    2 AB5 4 ILE C 210  VAL C 220 -1  N  MET C 217   O  ILE C 238           
SHEET    3 AB5 4 GLU C 282  VAL C 291 -1  O  VAL C 290   N  ILE C 211           
SHEET    4 AB5 4 THR C 297  TYR C 304 -1  O  ALA C 300   N  LEU C 287           
SHEET    1 AB6 2 THR C 223  THR C 224  0                                        
SHEET    2 AB6 2 VAL C 230  VAL C 231 -1  O  VAL C 231   N  THR C 223           
SHEET    1 AB7 2 GLN C 313  PHE C 315  0                                        
SHEET    2 AB7 2 THR C 336  LYS C 338 -1  O  ILE C 337   N  ARG C 314           
SHEET    1 AB8 3 ILE D 701  ILE D 703  0                                        
SHEET    2 AB8 3 VAL D 679  ILE D 682 -1  N  VAL D 679   O  ILE D 703           
SHEET    3 AB8 3 ALA D 736  PHE D 738 -1  O  ALA D 736   N  ILE D 682           
SHEET    1 AB9 2 PHE D 685  PHE D 686  0                                        
SHEET    2 AB9 2 LEU D 696  SER D 697 -1  O  LEU D 696   N  PHE D 686           
SHEET    1 AC1 6 ALA D 771  ALA D 773  0                                        
SHEET    2 AC1 6 VAL D 850  ASP D 854  1  O  ASP D 854   N  ALA D 773           
SHEET    3 AC1 6 THR D 883  VAL D 887  1  O  VAL D 885   N  VAL D 851           
SHEET    4 AC1 6 THR D 709  GLY D 713  1  N  THR D 709   O  VAL D 884           
SHEET    5 AC1 6 TRP D 899  LYS D 904  1  O  ILE D 901   N  VAL D 712           
SHEET    6 AC1 6 THR D 907  THR D 913 -1  O  THR D 907   N  LYS D 904           
SHEET    1 AC2 3 VAL D1365  ILE D1369  0                                        
SHEET    2 AC2 3 ILE D1345  ARG D1353 -1  N  LEU D1350   O  VAL D1365           
SHEET    3 AC2 3 MET D1398  ILE D1405 -1  O  GLU D1400   N  SER D1351           
SHEET    1 AC3 6 SER D1423  ILE D1425  0                                        
SHEET    2 AC3 6 PHE D1503  ASP D1506  1  O  ASP D1506   N  ILE D1425           
SHEET    3 AC3 6 VAL D1533  ILE D1536  1  O  VAL D1534   N  PHE D1503           
SHEET    4 AC3 6 ILE D1375  ILE D1377  1  N  ILE D1375   O  VAL D1533           
SHEET    5 AC3 6 LEU D1548  LEU D1552  1  O  LEU D1548   N  GLY D1376           
SHEET    6 AC3 6 ILE D1557  PHE D1560 -1  O  PHE D1560   N  VAL D1549           
SHEET    1 AC4 3 ALA E  45  LYS E  47  0                                        
SHEET    2 AC4 3 TYR G 326  ASP G 329  1  O  VAL G 328   N  LYS E  47           
SHEET    3 AC4 3 VAL G 319  GLU G 321 -1  N  ALA G 320   O  SER G 327           
SHEET    1 AC5 3 VAL E 188  ARG E 192  0                                        
SHEET    2 AC5 3 ARG E 195  LEU E 200 -1  O  MET E 199   N  VAL E 188           
SHEET    3 AC5 3 ILE E 257  VAL E 260 -1  O  HIS E 259   N  PHE E 198           
SHEET    1 AC6 4 VAL E 236  ILE E 238  0                                        
SHEET    2 AC6 4 ILE E 210  VAL E 220 -1  N  MET E 217   O  ILE E 238           
SHEET    3 AC6 4 GLU E 282  VAL E 291 -1  O  VAL E 290   N  ILE E 211           
SHEET    4 AC6 4 THR E 297  TYR E 304 -1  O  ALA E 300   N  LEU E 287           
SHEET    1 AC7 2 THR E 223  THR E 224  0                                        
SHEET    2 AC7 2 VAL E 230  VAL E 231 -1  O  VAL E 231   N  THR E 223           
SHEET    1 AC8 2 GLN E 313  PHE E 315  0                                        
SHEET    2 AC8 2 THR E 336  LYS E 338 -1  O  ILE E 337   N  ARG E 314           
SHEET    1 AC9 3 ILE F 701  ILE F 703  0                                        
SHEET    2 AC9 3 VAL F 679  ILE F 682 -1  N  VAL F 679   O  ILE F 703           
SHEET    3 AC9 3 ALA F 736  PHE F 738 -1  O  ALA F 736   N  ILE F 682           
SHEET    1 AD1 2 PHE F 685  PHE F 686  0                                        
SHEET    2 AD1 2 LEU F 696  SER F 697 -1  O  LEU F 696   N  PHE F 686           
SHEET    1 AD2 6 ALA F 771  ALA F 773  0                                        
SHEET    2 AD2 6 VAL F 850  ASP F 854  1  O  ASP F 854   N  ALA F 773           
SHEET    3 AD2 6 THR F 883  VAL F 887  1  O  VAL F 885   N  VAL F 851           
SHEET    4 AD2 6 THR F 709  GLY F 713  1  N  THR F 709   O  VAL F 884           
SHEET    5 AD2 6 TRP F 899  LYS F 904  1  O  ILE F 901   N  VAL F 712           
SHEET    6 AD2 6 THR F 907  THR F 913 -1  O  THR F 907   N  LYS F 904           
SHEET    1 AD3 3 VAL F1365  ILE F1369  0                                        
SHEET    2 AD3 3 ILE F1345  ARG F1353 -1  N  LEU F1350   O  VAL F1365           
SHEET    3 AD3 3 MET F1398  ILE F1405 -1  O  GLU F1400   N  SER F1351           
SHEET    1 AD4 6 SER F1423  ILE F1425  0                                        
SHEET    2 AD4 6 PHE F1503  ASP F1506  1  O  ASP F1506   N  ILE F1425           
SHEET    3 AD4 6 VAL F1533  ILE F1536  1  O  VAL F1534   N  PHE F1503           
SHEET    4 AD4 6 ILE F1375  ILE F1377  1  N  ILE F1375   O  VAL F1533           
SHEET    5 AD4 6 LEU F1548  LEU F1552  1  O  LEU F1548   N  GLY F1376           
SHEET    6 AD4 6 ILE F1557  PHE F1560 -1  O  PHE F1560   N  VAL F1549           
SHEET    1 AD5 3 VAL G 188  ARG G 192  0                                        
SHEET    2 AD5 3 ARG G 195  LEU G 200 -1  O  MET G 199   N  VAL G 188           
SHEET    3 AD5 3 ILE G 257  VAL G 260 -1  O  HIS G 259   N  PHE G 198           
SHEET    1 AD6 4 VAL G 236  ILE G 238  0                                        
SHEET    2 AD6 4 ILE G 210  VAL G 220 -1  N  MET G 217   O  ILE G 238           
SHEET    3 AD6 4 GLU G 282  VAL G 291 -1  O  VAL G 290   N  ILE G 211           
SHEET    4 AD6 4 THR G 297  TYR G 304 -1  O  ALA G 300   N  LEU G 287           
SHEET    1 AD7 2 THR G 223  THR G 224  0                                        
SHEET    2 AD7 2 VAL G 230  VAL G 231 -1  O  VAL G 231   N  THR G 223           
SHEET    1 AD8 2 GLN G 313  PHE G 315  0                                        
SHEET    2 AD8 2 THR G 336  LYS G 338 -1  O  ILE G 337   N  ARG G 314           
SHEET    1 AD9 3 ILE H 701  ILE H 703  0                                        
SHEET    2 AD9 3 VAL H 679  ILE H 682 -1  N  VAL H 679   O  ILE H 703           
SHEET    3 AD9 3 ALA H 736  PHE H 738 -1  O  ALA H 736   N  ILE H 682           
SHEET    1 AE1 2 PHE H 685  PHE H 686  0                                        
SHEET    2 AE1 2 LEU H 696  SER H 697 -1  O  LEU H 696   N  PHE H 686           
SHEET    1 AE2 6 ALA H 771  ALA H 773  0                                        
SHEET    2 AE2 6 VAL H 850  ASP H 854  1  O  ASP H 854   N  ALA H 773           
SHEET    3 AE2 6 THR H 883  VAL H 887  1  O  VAL H 885   N  VAL H 851           
SHEET    4 AE2 6 THR H 709  GLY H 713  1  N  THR H 709   O  VAL H 884           
SHEET    5 AE2 6 TRP H 899  LYS H 904  1  O  ILE H 901   N  VAL H 712           
SHEET    6 AE2 6 THR H 907  THR H 913 -1  O  THR H 907   N  LYS H 904           
SHEET    1 AE3 3 VAL H1365  ILE H1369  0                                        
SHEET    2 AE3 3 ILE H1345  ARG H1353 -1  N  LEU H1350   O  VAL H1365           
SHEET    3 AE3 3 MET H1398  ILE H1405 -1  O  GLU H1400   N  SER H1351           
SHEET    1 AE4 6 SER H1423  ILE H1425  0                                        
SHEET    2 AE4 6 PHE H1503  ASP H1506  1  O  ASP H1506   N  ILE H1425           
SHEET    3 AE4 6 VAL H1533  ILE H1536  1  O  VAL H1534   N  PHE H1503           
SHEET    4 AE4 6 ILE H1375  ILE H1377  1  N  ILE H1375   O  VAL H1533           
SHEET    5 AE4 6 LEU H1548  LEU H1552  1  O  LEU H1548   N  GLY H1376           
SHEET    6 AE4 6 ILE H1557  PHE H1560 -1  O  PHE H1560   N  VAL H1549           
SSBOND   1 CYS A  110    CYS A  142                          1555   1555  2.03  
SSBOND   2 CYS C  110    CYS C  142                          1555   1555  2.03  
SSBOND   3 CYS E  110    CYS E  142                          1555   1555  2.03  
SSBOND   4 CYS G  110    CYS G  142                          1555   1555  2.03  
SITE     1 AC1  8 ILE A 182  PHE A 183  LYS A 185  TYR A 330                    
SITE     2 AC1  8 PHE A 333  GLY A 334  ASN G  48  ARG G  50                    
SITE     1 AC2  9 ARG B 306  TYR B 377  ILE B 381  PHE B 433                    
SITE     2 AC2  9 LEU B 434  ASN B 437  LEU B 592  THR B1242                    
SITE     3 AC2  9 ARG B1246                                                     
SITE     1 AC3  9 THR B 404  TRP B 688  GLY B 716  CYS B 717                    
SITE     2 AC3  9 GLY B 718  LYS B 719  SER B 720  SER B 721                    
SITE     3 AC3  9 GLN B 775                                                     
SITE     1 AC4  8 ASN A  48  ARG A  50  ILE C 182  PHE C 183                    
SITE     2 AC4  8 LYS C 185  TYR C 330  PHE C 333  GLY C 334                    
SITE     1 AC5  9 ARG D 306  TYR D 377  ILE D 381  PHE D 433                    
SITE     2 AC5  9 LEU D 434  ASN D 437  LEU D 592  THR D1242                    
SITE     3 AC5  9 ARG D1246                                                     
SITE     1 AC6  9 THR D 404  TRP D 688  GLY D 716  CYS D 717                    
SITE     2 AC6  9 GLY D 718  LYS D 719  SER D 720  SER D 721                    
SITE     3 AC6  9 GLN D 775                                                     
SITE     1 AC7  8 ASN C  48  ARG C  50  ILE E 182  PHE E 183                    
SITE     2 AC7  8 LYS E 185  TYR E 330  PHE E 333  GLY E 334                    
SITE     1 AC8  9 ARG F 306  TYR F 377  ILE F 381  PHE F 433                    
SITE     2 AC8  9 LEU F 434  ASN F 437  LEU F 592  THR F1242                    
SITE     3 AC8  9 ARG F1246                                                     
SITE     1 AC9  9 THR F 404  TRP F 688  GLY F 716  CYS F 717                    
SITE     2 AC9  9 GLY F 718  LYS F 719  SER F 720  SER F 721                    
SITE     3 AC9  9 GLN F 775                                                     
SITE     1 AD1  8 ASN E  48  ARG E  50  ILE G 182  PHE G 183                    
SITE     2 AD1  8 LYS G 185  TYR G 330  PHE G 333  GLY G 334                    
SITE     1 AD2  9 ARG H 306  TYR H 377  ILE H 381  PHE H 433                    
SITE     2 AD2  9 LEU H 434  ASN H 437  LEU H 592  THR H1242                    
SITE     3 AD2  9 ARG H1246                                                     
SITE     1 AD3  9 THR H 404  TRP H 688  GLY H 716  CYS H 717                    
SITE     2 AD3  9 GLY H 718  LYS H 719  SER H 720  SER H 721                    
SITE     3 AD3  9 GLN H 775                                                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.003038  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.003038  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.003038        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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