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Entry: 5YOY
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HEADER    IMMUNE SYSTEM                           31-OCT-17   5YOY              
TITLE     CRYSTAL STRUCTURE OF THE HUMAN TUMOR NECROSIS FACTOR IN COMPLEX WITH  
TITLE    2 GOLIMUMAB FV                                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TUMOR NECROSIS FACTOR;                                     
COMPND   3 CHAIN: A, B, C, J, K, L;                                             
COMPND   4 SYNONYM: CACHECTIN,TNF-ALPHA,TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY
COMPND   5 MEMBER 2,TNF-A;                                                      
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: GOLIMUMAB LIGHT CHAIN VARIABLE REGION;                     
COMPND   9 CHAIN: D, E, F, M, N, O;                                             
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: GOLIMUMAB HEAVY CHAIN VARIABLE REGION;                     
COMPND  13 CHAIN: G, H, I, P, Q, R;                                             
COMPND  14 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: TNF, TNFA, TNFSF2;                                             
SOURCE   6 EXPRESSION_SYSTEM: BREVIBACILLUS CHOSHINENSIS;                       
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 54911;                                      
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_TAXID: 9606;                                                
SOURCE  11 EXPRESSION_SYSTEM: BREVIBACILLUS CHOSHINENSIS;                       
SOURCE  12 EXPRESSION_SYSTEM_TAXID: 54911;                                      
SOURCE  13 MOL_ID: 3;                                                           
SOURCE  14 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  15 ORGANISM_TAXID: 9606;                                                
SOURCE  16 EXPRESSION_SYSTEM: BREVIBACILLUS CHOSHINENSIS;                       
SOURCE  17 EXPRESSION_SYSTEM_TAXID: 54911                                       
KEYWDS    CYTOKINE, ANTIBODY, IMMUNE SYSTEM                                     
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    M.ONO,S.HORITA,Y.SATO,Y.NOMURA,S.IWATA,N.NOMURA                       
REVDAT   3   14-NOV-18 5YOY    1       REMARK                                   
REVDAT   2   20-JUN-18 5YOY    1       JRNL                                     
REVDAT   1   09-MAY-18 5YOY    0                                                
JRNL        AUTH   M.ONO,S.HORITA,Y.SATO,Y.NOMURA,S.IWATA,N.NOMURA              
JRNL        TITL   STRUCTURAL BASIS FOR TUMOR NECROSIS FACTOR BLOCKADE WITH THE 
JRNL        TITL 2 THERAPEUTIC ANTIBODY GOLIMUMAB                               
JRNL        REF    PROTEIN SCI.                  V.  27  1038 2018              
JRNL        REFN                   ESSN 1469-896X                               
JRNL        PMID   29575262                                                     
JRNL        DOI    10.1002/PRO.3407                                             
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.73 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX DEV_2210                                      
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.73                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 46.25                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.370                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.1                           
REMARK   3   NUMBER OF REFLECTIONS             : 77902                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.192                           
REMARK   3   R VALUE            (WORKING SET) : 0.190                           
REMARK   3   FREE R VALUE                     : 0.234                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.050                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 3936                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 46.2568 -  8.2665    0.95     2726   136  0.1699 0.2051        
REMARK   3     2  8.2665 -  6.5673    0.98     2681   160  0.1716 0.2140        
REMARK   3     3  6.5673 -  5.7389    0.94     2605   141  0.1741 0.2550        
REMARK   3     4  5.7389 -  5.2150    0.97     2683   130  0.1548 0.1995        
REMARK   3     5  5.2150 -  4.8416    0.97     2674   113  0.1408 0.1707        
REMARK   3     6  4.8416 -  4.5564    0.98     2662   145  0.1335 0.1783        
REMARK   3     7  4.5564 -  4.3284    0.97     2632   152  0.1376 0.1483        
REMARK   3     8  4.3284 -  4.1401    0.94     2539   157  0.1523 0.1946        
REMARK   3     9  4.1401 -  3.9808    0.97     2655   120  0.1674 0.2334        
REMARK   3    10  3.9808 -  3.8435    0.98     2663   149  0.1790 0.2277        
REMARK   3    11  3.8435 -  3.7234    0.98     2655   148  0.1899 0.2315        
REMARK   3    12  3.7234 -  3.6170    0.98     2664   149  0.1916 0.2496        
REMARK   3    13  3.6170 -  3.5218    0.98     2676   119  0.1928 0.2090        
REMARK   3    14  3.5218 -  3.4359    0.98     2667   155  0.2109 0.2602        
REMARK   3    15  3.4359 -  3.3579    0.98     2687   133  0.2231 0.2771        
REMARK   3    16  3.3579 -  3.2864    0.98     2657   127  0.2366 0.3039        
REMARK   3    17  3.2864 -  3.2207    0.98     2665   141  0.2331 0.2774        
REMARK   3    18  3.2207 -  3.1599    0.95     2567   127  0.2463 0.3113        
REMARK   3    19  3.1599 -  3.1035    0.97     2637   146  0.2470 0.3178        
REMARK   3    20  3.1035 -  3.0509    0.98     2600   161  0.2578 0.2546        
REMARK   3    21  3.0509 -  3.0017    0.99     2725   139  0.2653 0.3118        
REMARK   3    22  3.0017 -  2.9555    0.99     2649   137  0.2748 0.3138        
REMARK   3    23  2.9555 -  2.9121    0.98     2648   154  0.2954 0.3277        
REMARK   3    24  2.9121 -  2.8711    0.98     2659   152  0.3085 0.3526        
REMARK   3    25  2.8711 -  2.8323    0.98     2615   143  0.3230 0.3643        
REMARK   3    26  2.8323 -  2.7955    0.98     2711   128  0.3170 0.3340        
REMARK   3    27  2.7955 -  2.7606    0.99     2639   142  0.3441 0.3444        
REMARK   3    28  2.7606 -  2.7273    0.87     2325   132  0.3543 0.3991        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.430            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 25.880           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 77.83                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.003          18480                                  
REMARK   3   ANGLE     :  0.672          25132                                  
REMARK   3   CHIRALITY :  0.047           2714                                  
REMARK   3   PLANARITY :  0.005           3266                                  
REMARK   3   DIHEDRAL  : 14.068          10964                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 140                                        
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 6 THROUGH 22 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 223.8106-423.4674 263.8461              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1467 T22:   1.5449                                     
REMARK   3      T33:   0.4908 T12:  -0.2144                                     
REMARK   3      T13:  -0.0077 T23:  -0.1370                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.4107 L22:   6.4380                                     
REMARK   3      L33:   6.3688 L12:  -4.0906                                     
REMARK   3      L13:   1.4592 L23:  -0.3218                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.4323 S12:   4.4586 S13:  -1.9731                       
REMARK   3      S21:  -1.6975 S22:   0.7952 S23:  -0.0385                       
REMARK   3      S31:   0.5167 S32:   0.2854 S33:   0.5684                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 23 THROUGH 32 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 234.1807-416.2948 266.4538              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0663 T22:   1.5317                                     
REMARK   3      T33:   0.7542 T12:  -0.4090                                     
REMARK   3      T13:  -0.1203 T23:   0.1729                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3297 L22:   6.9400                                     
REMARK   3      L33:   2.6055 L12:   1.3280                                     
REMARK   3      L13:  -2.4147 L23:  -2.1726                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4720 S12:   1.0689 S13:  -0.1637                       
REMARK   3      S21:  -1.2822 S22:  -0.7131 S23:  -0.3239                       
REMARK   3      S31:  -0.0082 S32:   1.1472 S33:   1.2183                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 33 THROUGH 75 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 226.9420-417.3419 273.2406              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7637 T22:   0.7877                                     
REMARK   3      T33:   0.4341 T12:  -0.2973                                     
REMARK   3      T13:  -0.0806 T23:   0.1388                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.9132 L22:   2.4207                                     
REMARK   3      L33:   4.2985 L12:   0.3159                                     
REMARK   3      L13:   0.8551 L23:  -0.0974                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6497 S12:   1.4803 S13:   0.2294                       
REMARK   3      S21:  -0.8810 S22:   0.4116 S23:   0.1818                       
REMARK   3      S31:  -0.6999 S32:   0.5217 S33:   0.2353                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 76 THROUGH 98 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 221.0608-410.4442 279.5708              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9014 T22:   0.5787                                     
REMARK   3      T33:   0.7398 T12:  -0.1148                                     
REMARK   3      T13:  -0.2507 T23:   0.1077                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.5437 L22:   4.7605                                     
REMARK   3      L33:   8.7910 L12:   3.8161                                     
REMARK   3      L13:  -1.9004 L23:   2.8091                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2759 S12:   0.8085 S13:   1.8715                       
REMARK   3      S21:  -0.6934 S22:  -0.4412 S23:   0.9239                       
REMARK   3      S31:  -1.9585 S32:  -0.3587 S33:   0.6957                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 99 THROUGH 126 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 237.4574-419.7152 286.8970              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5389 T22:   0.7140                                     
REMARK   3      T33:   0.4174 T12:  -0.1917                                     
REMARK   3      T13:   0.0095 T23:  -0.0207                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.4657 L22:   2.2356                                     
REMARK   3      L33:   5.5734 L12:   0.5784                                     
REMARK   3      L13:   3.6712 L23:  -0.5716                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3619 S12:  -1.4782 S13:  -0.2402                       
REMARK   3      S21:  -0.1012 S22:   0.1532 S23:  -0.3263                       
REMARK   3      S31:  -0.5326 S32:   0.1120 S33:   0.3329                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 127 THROUGH 136 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 219.2177-411.2056 271.7682              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0683 T22:   0.9178                                     
REMARK   3      T33:   0.6864 T12:  -0.1093                                     
REMARK   3      T13:  -0.3240 T23:   0.1188                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.0172 L22:   3.5192                                     
REMARK   3      L33:   4.9739 L12:  -1.5933                                     
REMARK   3      L13:   4.7568 L23:  -1.4679                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.2263 S12:   0.1612 S13:   2.1007                       
REMARK   3      S21:  -0.5501 S22:  -0.0116 S23:   0.6290                       
REMARK   3      S31:  -0.9165 S32:  -0.1194 S33:   1.1350                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 137 THROUGH 159 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 230.6663-420.2124 274.2422              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8291 T22:   0.7858                                     
REMARK   3      T33:   0.4890 T12:  -0.2800                                     
REMARK   3      T13:   0.0014 T23:  -0.0072                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1599 L22:   4.5401                                     
REMARK   3      L33:   6.6882 L12:   3.7113                                     
REMARK   3      L13:   2.7765 L23:   1.9877                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4532 S12:   0.8782 S13:  -0.1873                       
REMARK   3      S21:  -0.9322 S22:   0.5287 S23:  -0.1773                       
REMARK   3      S31:  -0.3710 S32:   0.4746 S33:  -0.0115                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 6 THROUGH 22 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 206.8902-419.9091 284.3099              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8305 T22:   0.8257                                     
REMARK   3      T33:   0.7117 T12:   0.0319                                     
REMARK   3      T13:  -0.1973 T23:   0.0554                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.9131 L22:   8.9899                                     
REMARK   3      L33:   4.4025 L12:   2.4114                                     
REMARK   3      L13:   1.8322 L23:   6.2649                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.0425 S12:   0.3425 S13:   1.0670                       
REMARK   3      S21:  -0.6682 S22:  -0.1558 S23:   1.1306                       
REMARK   3      S31:  -1.6121 S32:  -2.1179 S33:   1.4367                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 23 THROUGH 32 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 210.3764-417.0785 294.7976              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6731 T22:   0.9358                                     
REMARK   3      T33:   1.1103 T12:   0.1196                                     
REMARK   3      T13:  -0.0139 T23:  -0.2124                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.3435 L22:   7.4115                                     
REMARK   3      L33:   3.6255 L12:   4.5415                                     
REMARK   3      L13:   3.2438 L23:   5.1901                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1446 S12:  -0.6309 S13:   1.5093                       
REMARK   3      S21:  -0.5751 S22:  -0.4956 S23:   0.5241                       
REMARK   3      S31:  -1.0275 S32:  -2.5337 S33:   0.4882                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 33 THROUGH 67 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 210.3176-425.4742 287.5055              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5156 T22:   0.5713                                     
REMARK   3      T33:   0.5157 T12:  -0.0293                                     
REMARK   3      T13:  -0.0494 T23:  -0.0263                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.7770 L22:   3.3436                                     
REMARK   3      L33:   7.5697 L12:   3.1462                                     
REMARK   3      L13:   2.5351 L23:   1.8482                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2631 S12:   0.2807 S13:   0.5695                       
REMARK   3      S21:  -0.2657 S22:  -0.0631 S23:   0.9029                       
REMARK   3      S31:  -0.1293 S32:  -1.1735 S33:   0.2360                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 68 THROUGH 75 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 233.1549-424.8698 305.6816              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8780 T22:   0.5507                                     
REMARK   3      T33:   0.6298 T12:  -0.0294                                     
REMARK   3      T13:  -0.0254 T23:  -0.0303                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1319 L22:   2.0434                                     
REMARK   3      L33:   2.0510 L12:   2.0608                                     
REMARK   3      L13:   2.1112 L23:   2.0171                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4155 S12:  -0.5246 S13:  -1.4888                       
REMARK   3      S21:  -0.3847 S22:   0.4327 S23:  -2.0946                       
REMARK   3      S31:   1.3988 S32:  -0.3539 S33:  -0.4038                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 76 THROUGH 98 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 214.7538-435.8385 293.8675              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6754 T22:   0.5624                                     
REMARK   3      T33:   0.5623 T12:  -0.1809                                     
REMARK   3      T13:   0.1308 T23:  -0.0506                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.1121 L22:   2.4729                                     
REMARK   3      L33:   3.7096 L12:   1.5119                                     
REMARK   3      L13:   3.1018 L23:   2.4367                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0049 S12:  -1.2057 S13:   0.3087                       
REMARK   3      S21:   0.5610 S22:  -0.3790 S23:   0.7933                       
REMARK   3      S31:   0.5035 S32:  -0.9688 S33:   0.3486                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 99 THROUGH 112 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 239.6626-419.0647 304.4465              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8179 T22:   0.6186                                     
REMARK   3      T33:   0.6898 T12:  -0.0831                                     
REMARK   3      T13:  -0.0090 T23:  -0.1140                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.7038 L22:   5.9689                                     
REMARK   3      L33:   9.3749 L12:   6.1991                                     
REMARK   3      L13:   7.9886 L23:   7.3736                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0266 S12:   0.7717 S13:  -1.2409                       
REMARK   3      S21:   0.0263 S22:   0.7917 S23:  -1.5438                       
REMARK   3      S31:   0.1855 S32:   0.5229 S33:  -0.9120                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 113 THROUGH 126 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 222.7449-427.0076 288.4890              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7686 T22:   0.6025                                     
REMARK   3      T33:   0.3217 T12:  -0.2079                                     
REMARK   3      T13:   0.0597 T23:  -0.0238                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.0206 L22:   6.3647                                     
REMARK   3      L33:   4.5571 L12:   5.9055                                     
REMARK   3      L13:   6.0154 L23:   3.4893                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.1648 S12:   0.8466 S13:   0.1231                       
REMARK   3      S21:  -1.0583 S22:   0.8680 S23:   0.0741                       
REMARK   3      S31:  -0.5863 S32:   0.4920 S33:   0.4133                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 127 THROUGH 136 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 208.0252-433.1749 291.3468              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7715 T22:   0.6890                                     
REMARK   3      T33:   0.5812 T12:  -0.2007                                     
REMARK   3      T13:  -0.0060 T23:   0.0445                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.7231 L22:   3.2598                                     
REMARK   3      L33:   9.7161 L12:   3.1808                                     
REMARK   3      L13:   5.9086 L23:   5.4132                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.0852 S12:  -0.1220 S13:  -0.0021                       
REMARK   3      S21:   1.4256 S22:  -0.8826 S23:  -0.1031                       
REMARK   3      S31:   1.4329 S32:  -0.9584 S33:  -0.3086                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 137 THROUGH 159 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 217.5671-421.8483 290.5519              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5909 T22:   0.4348                                     
REMARK   3      T33:   0.3892 T12:  -0.0230                                     
REMARK   3      T13:  -0.0035 T23:   0.0158                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.4266 L22:   4.8674                                     
REMARK   3      L33:   8.3461 L12:   5.0396                                     
REMARK   3      L13:   4.9722 L23:   3.9250                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.7275 S12:   0.3634 S13:   0.4479                       
REMARK   3      S21:  -0.5973 S22:   0.4346 S23:   0.5459                       
REMARK   3      S31:  -0.9757 S32:  -0.4700 S33:   0.2013                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 6 THROUGH 53 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 221.1844-445.9109 276.4929              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3667 T22:   0.7803                                     
REMARK   3      T33:   1.0688 T12:  -0.3945                                     
REMARK   3      T13:  -0.3985 T23:   0.0547                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.5393 L22:   8.7036                                     
REMARK   3      L33:   8.2442 L12:  -2.3638                                     
REMARK   3      L13:   4.4203 L23:  -2.0251                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.7003 S12:   0.0576 S13:  -1.8500                       
REMARK   3      S21:   1.1750 S22:   0.3510 S23:   0.4190                       
REMARK   3      S31:   1.3660 S32:  -0.7027 S33:  -1.0844                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 54 THROUGH 136 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 234.7230-434.8589 280.6817              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6265 T22:   0.6882                                     
REMARK   3      T33:   0.4081 T12:  -0.1176                                     
REMARK   3      T13:   0.1076 T23:  -0.0256                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.9096 L22:   1.6814                                     
REMARK   3      L33:   5.5899 L12:  -1.2358                                     
REMARK   3      L13:   3.4681 L23:  -2.1159                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0188 S12:   0.9624 S13:  -0.3417                       
REMARK   3      S21:  -0.2233 S22:  -0.0123 S23:  -0.0542                       
REMARK   3      S31:   0.1004 S32:   0.9139 S33:  -0.0690                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 137 THROUGH 159 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 227.5651-439.0577 283.2196              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8377 T22:   0.6414                                     
REMARK   3      T33:   0.4413 T12:  -0.2479                                     
REMARK   3      T13:   0.0086 T23:   0.0490                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.5843 L22:   2.2366                                     
REMARK   3      L33:   5.8286 L12:  -3.1052                                     
REMARK   3      L13:   6.0800 L23:  -1.9550                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0047 S12:  -0.5391 S13:  -0.5324                       
REMARK   3      S21:   0.0329 S22:   0.3659 S23:   0.3976                       
REMARK   3      S31:   0.5297 S32:  -0.6692 S33:  -0.4967                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 1 THROUGH 25 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 216.9165-414.9264 329.5358              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7412 T22:   0.4877                                     
REMARK   3      T33:   0.5352 T12:   0.0871                                     
REMARK   3      T13:   0.1338 T23:  -0.0257                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0274 L22:   2.5333                                     
REMARK   3      L33:   5.4714 L12:   0.7065                                     
REMARK   3      L13:   1.0283 L23:  -1.4680                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0863 S12:  -0.1821 S13:  -0.2956                       
REMARK   3      S21:   0.4559 S22:  -0.1051 S23:   0.3806                       
REMARK   3      S31:  -0.1035 S32:  -0.8859 S33:   0.1798                       
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 26 THROUGH 32 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 217.8442-417.8720 311.8343              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5847 T22:   0.6401                                     
REMARK   3      T33:   0.4424 T12:   0.0705                                     
REMARK   3      T13:   0.0401 T23:  -0.0201                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.3119 L22:   5.8828                                     
REMARK   3      L33:   9.1081 L12:  -5.5708                                     
REMARK   3      L13:  -6.8940 L23:   7.2698                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.4052 S12:   2.4478 S13:   0.2281                       
REMARK   3      S21:  -0.9028 S22:  -1.5079 S23:   0.0107                       
REMARK   3      S31:  -0.0448 S32:  -1.5794 S33:   0.0704                       
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 33 THROUGH 48 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 229.3887-410.1286 326.6029              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8234 T22:   0.2739                                     
REMARK   3      T33:   0.3899 T12:  -0.0417                                     
REMARK   3      T13:   0.0203 T23:   0.0122                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.1472 L22:   4.4310                                     
REMARK   3      L33:   4.0602 L12:   4.2907                                     
REMARK   3      L13:  -1.4978 L23:   0.9793                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.9231 S12:  -0.5701 S13:   0.3292                       
REMARK   3      S21:   0.8243 S22:  -0.4204 S23:  -0.1027                       
REMARK   3      S31:  -0.9705 S32:   0.2529 S33:  -0.4927                       
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 49 THROUGH 75 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 226.6884-420.6339 324.4166              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6501 T22:   0.3218                                     
REMARK   3      T33:   0.3512 T12:  -0.0002                                     
REMARK   3      T13:   0.0816 T23:   0.0607                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4141 L22:   4.1363                                     
REMARK   3      L33:   2.1366 L12:   0.7250                                     
REMARK   3      L13:   0.8789 L23:   2.3932                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0077 S12:  -0.0473 S13:  -0.0820                       
REMARK   3      S21:   0.1963 S22:  -0.1616 S23:   0.1790                       
REMARK   3      S31:   0.7283 S32:   0.1136 S33:   0.0116                       
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 76 THROUGH 84 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 228.6330-415.6994 338.4910              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6712 T22:   0.4564                                     
REMARK   3      T33:   0.4588 T12:   0.0450                                     
REMARK   3      T13:   0.1469 T23:   0.0045                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.5284 L22:   3.6831                                     
REMARK   3      L33:   5.1983 L12:   0.0840                                     
REMARK   3      L13:   3.5111 L23:  -0.8742                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3940 S12:  -0.2161 S13:   0.2408                       
REMARK   3      S21:   0.6909 S22:   1.3137 S23:  -0.4522                       
REMARK   3      S31:  -0.3012 S32:  -0.7485 S33:  -0.2289                       
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 85 THROUGH 103 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 221.4715-409.1030 318.0764              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6215 T22:   0.3059                                     
REMARK   3      T33:   0.3532 T12:  -0.0486                                     
REMARK   3      T13:   0.0024 T23:   0.0545                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6875 L22:   8.0334                                     
REMARK   3      L33:   2.9061 L12:  -1.5184                                     
REMARK   3      L13:  -0.7117 L23:   4.6190                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0155 S12:   0.1747 S13:   0.0250                       
REMARK   3      S21:  -0.0779 S22:  -0.3395 S23:   0.5486                       
REMARK   3      S31:  -0.8442 S32:  -0.3717 S33:   0.2572                       
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 104 THROUGH 108 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 220.6145-409.7545 340.5305              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1585 T22:   0.7629                                     
REMARK   3      T33:   0.6447 T12:   0.0163                                     
REMARK   3      T13:  -0.0048 T23:  -0.1244                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.0641 L22:   2.9035                                     
REMARK   3      L33:   5.3849 L12:  -1.4810                                     
REMARK   3      L13:  -0.6035 L23:   3.7570                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4562 S12:  -1.7698 S13:   1.9269                       
REMARK   3      S21:   0.7065 S22:   0.0448 S23:   0.3555                       
REMARK   3      S31:  -0.1554 S32:   1.3875 S33:  -1.0624                       
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 1 THROUGH 18 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 258.3802-463.9353 293.8358              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7873 T22:   0.8343                                     
REMARK   3      T33:   1.1175 T12:   0.0950                                     
REMARK   3      T13:   0.1137 T23:  -0.2998                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.1413 L22:   6.6231                                     
REMARK   3      L33:   5.2996 L12:  -3.4618                                     
REMARK   3      L13:  -4.6941 L23:   3.1114                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0444 S12:   1.4530 S13:  -1.7603                       
REMARK   3      S21:  -0.0221 S22:   0.3397 S23:  -1.3118                       
REMARK   3      S31:   0.4352 S32:   1.0138 S33:  -0.2001                       
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 19 THROUGH 25 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 255.7021-460.6592 290.2426              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0070 T22:   0.9406                                     
REMARK   3      T33:   0.9707 T12:  -0.1052                                     
REMARK   3      T13:   0.3815 T23:  -0.2595                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4918 L22:   6.4180                                     
REMARK   3      L33:   8.0183 L12:  -5.1973                                     
REMARK   3      L13:   5.6263 L23:  -6.0381                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6116 S12:   1.4029 S13:  -1.2568                       
REMARK   3      S21:  -1.1948 S22:  -0.0050 S23:  -0.9263                       
REMARK   3      S31:   1.0352 S32:   0.8683 S33:   0.5050                       
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 26 THROUGH 38 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 249.8751-452.9487 294.2220              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5167 T22:   0.7271                                     
REMARK   3      T33:   0.5596 T12:   0.0026                                     
REMARK   3      T13:   0.0825 T23:  -0.0332                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.3132 L22:   9.6345                                     
REMARK   3      L33:   4.3649 L12:  -0.7581                                     
REMARK   3      L13:   6.0587 L23:   0.7968                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3486 S12:   0.7226 S13:  -1.0554                       
REMARK   3      S21:  -0.2416 S22:   0.6107 S23:   0.2538                       
REMARK   3      S31:  -0.0483 S32:   0.4000 S33:  -0.2149                       
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 39 THROUGH 48 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 259.7921-454.4704 305.9940              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6751 T22:   0.8096                                     
REMARK   3      T33:   0.7624 T12:   0.1383                                     
REMARK   3      T13:  -0.0383 T23:  -0.1316                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.4191 L22:   9.0864                                     
REMARK   3      L33:   5.0429 L12:   3.3434                                     
REMARK   3      L13:  -3.0171 L23:  -6.6675                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.7032 S12:  -0.4132 S13:  -0.5315                       
REMARK   3      S21:   0.0417 S22:  -0.6840 S23:  -1.4513                       
REMARK   3      S31:   0.9610 S32:   3.2206 S33:  -0.0808                       
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 49 THROUGH 61 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 261.2556-446.6978 296.3060              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7263 T22:   1.0171                                     
REMARK   3      T33:   0.8590 T12:   0.0315                                     
REMARK   3      T13:   0.2090 T23:  -0.2891                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.7984 L22:   5.4457                                     
REMARK   3      L33:   5.2298 L12:   3.2947                                     
REMARK   3      L13:   1.7791 L23:  -1.8413                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6648 S12:  -0.4366 S13:   0.1623                       
REMARK   3      S21:  -0.2458 S22:   0.4380 S23:  -1.2041                       
REMARK   3      S31:  -0.6269 S32:   1.4193 S33:  -1.0117                       
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 62 THROUGH 84 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 262.5482-456.3701 294.0003              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7429 T22:   1.0919                                     
REMARK   3      T33:   0.9224 T12:   0.0021                                     
REMARK   3      T13:   0.1829 T23:  -0.3069                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.0169 L22:   8.1143                                     
REMARK   3      L33:   2.8788 L12:   1.9304                                     
REMARK   3      L13:  -3.0326 L23:  -2.9289                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3004 S12:   0.7330 S13:  -0.0715                       
REMARK   3      S21:  -0.4451 S22:   0.1761 S23:  -1.4648                       
REMARK   3      S31:   0.4569 S32:   1.2844 S33:   0.0499                       
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 85 THROUGH 90 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 253.2472-457.6704 299.4898              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6234 T22:   0.6334                                     
REMARK   3      T33:   0.9094 T12:   0.0195                                     
REMARK   3      T13:   0.0947 T23:  -0.2329                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.2104 L22:   6.4576                                     
REMARK   3      L33:   7.6211 L12:  -6.3439                                     
REMARK   3      L13:   6.8579 L23:  -6.9737                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1281 S12:   0.5212 S13:  -0.7413                       
REMARK   3      S21:  -0.9919 S22:   0.3404 S23:  -1.0031                       
REMARK   3      S31:   0.7685 S32:   0.5240 S33:  -0.4501                       
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 91 THROUGH 103 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 244.3664-455.1996 298.3692              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7553 T22:   0.6420                                     
REMARK   3      T33:   0.5655 T12:   0.0005                                     
REMARK   3      T13:   0.0909 T23:  -0.0385                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.7880 L22:   8.3925                                     
REMARK   3      L33:   3.0877 L12:  -4.2125                                     
REMARK   3      L13:  -3.2858 L23:   2.4328                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0743 S12:   0.0400 S13:  -0.6088                       
REMARK   3      S21:  -1.4098 S22:   0.6406 S23:   0.1275                       
REMARK   3      S31:   0.8021 S32:   0.0418 S33:  -0.5346                       
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 104 THROUGH 108 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 266.0939-468.0101 300.9747              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4419 T22:   0.9644                                     
REMARK   3      T33:   1.3337 T12:   0.3846                                     
REMARK   3      T13:  -0.0310 T23:  -0.3291                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.7421 L22:   6.8882                                     
REMARK   3      L33:   3.0461 L12:  -0.5995                                     
REMARK   3      L13:  -2.5871 L23:   2.5602                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.9120 S12:  -2.3433 S13:   1.3530                       
REMARK   3      S21:   2.2018 S22:   0.8252 S23:  -1.7134                       
REMARK   3      S31:  -0.2576 S32:   0.1972 S33:   0.1238                       
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 1 THROUGH 7 )                     
REMARK   3    ORIGIN FOR THE GROUP (A): 252.3303-399.8167 268.3076              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1362 T22:   1.0598                                     
REMARK   3      T33:   0.6269 T12:  -0.2003                                     
REMARK   3      T13:   0.0374 T23:  -0.0062                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.7744 L22:   2.9717                                     
REMARK   3      L33:   3.9299 L12:  -1.7756                                     
REMARK   3      L13:  -4.1867 L23:  -1.0174                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2497 S12:   0.2881 S13:   0.8611                       
REMARK   3      S21:  -2.5812 S22:   0.0102 S23:  -0.2211                       
REMARK   3      S31:  -0.5303 S32:   0.8707 S33:  -0.3820                       
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 8 THROUGH 18 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 260.6822-382.5997 278.2654              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7135 T22:   1.1180                                     
REMARK   3      T33:   1.2154 T12:  -0.5898                                     
REMARK   3      T13:   0.5180 T23:  -0.0315                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.1274 L22:   5.3371                                     
REMARK   3      L33:   1.1068 L12:   5.1790                                     
REMARK   3      L13:   1.8770 L23:   2.1036                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0432 S12:   0.7584 S13:  -0.4021                       
REMARK   3      S21:  -1.5357 S22:   0.9310 S23:  -1.2544                       
REMARK   3      S31:  -1.1399 S32:   0.2951 S33:  -1.1496                       
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 19 THROUGH 25 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 252.2920-391.8770 274.8727              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4219 T22:   1.2164                                     
REMARK   3      T33:   1.1987 T12:  -0.4565                                     
REMARK   3      T13:   0.1818 T23:   0.3866                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.4534 L22:   3.9060                                     
REMARK   3      L33:   4.7839 L12:   5.0361                                     
REMARK   3      L13:   6.0394 L23:   4.2430                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.7105 S12:   2.2794 S13:   1.9850                       
REMARK   3      S21:  -2.3813 S22:   1.9484 S23:   0.7079                       
REMARK   3      S31:  -2.4423 S32:   0.4872 S33:  -0.2551                       
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 26 THROUGH 32 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 244.9705-404.5266 274.8290              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3878 T22:   1.0193                                     
REMARK   3      T33:   0.6249 T12:  -0.5406                                     
REMARK   3      T13:   0.1254 T23:   0.2747                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.8540 L22:   2.6490                                     
REMARK   3      L33:   3.8604 L12:  -1.1224                                     
REMARK   3      L13:  -2.8713 L23:  -1.6203                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0639 S12:   0.9285 S13:   0.8958                       
REMARK   3      S21:  -1.0701 S22:  -0.3777 S23:   0.1957                       
REMARK   3      S31:   0.8993 S32:   0.4916 S33:  -0.0219                       
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 33 THROUGH 48 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 263.1609-399.1415 282.0662              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9710 T22:   1.4418                                     
REMARK   3      T33:   0.7995 T12:  -0.7087                                     
REMARK   3      T13:   0.3939 T23:  -0.2240                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.9009 L22:   7.6658                                     
REMARK   3      L33:   3.5008 L12:   0.1882                                     
REMARK   3      L13:  -4.2418 L23:  -1.9020                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1194 S12:  -0.5612 S13:   0.5159                       
REMARK   3      S21:   0.2854 S22:   0.0704 S23:  -1.1728                       
REMARK   3      S31:  -0.2459 S32:   1.1963 S33:  -0.0988                       
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 49 THROUGH 61 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 255.3198-397.6758 289.6112              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1710 T22:   1.4537                                     
REMARK   3      T33:   0.7276 T12:  -0.5069                                     
REMARK   3      T13:   0.2657 T23:  -0.2086                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.2759 L22:   7.7799                                     
REMARK   3      L33:   4.7465 L12:   5.0782                                     
REMARK   3      L13:   5.9553 L23:   5.3627                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6530 S12:  -0.9006 S13:  -0.4518                       
REMARK   3      S21:   0.3297 S22:  -0.2222 S23:  -0.5944                       
REMARK   3      S31:  -0.7554 S32:  -0.5346 S33:  -0.4319                       
REMARK   3   TLS GROUP : 42                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 62 THROUGH 67 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 250.9634-393.8548 283.9115              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.8187 T22:   0.9040                                     
REMARK   3      T33:   1.0230 T12:  -0.3630                                     
REMARK   3      T13:   0.3768 T23:  -0.1013                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.8950 L22:   8.4621                                     
REMARK   3      L33:   8.3831 L12:   8.0804                                     
REMARK   3      L13:   6.8231 L23:   7.1726                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.0739 S12:   1.7900 S13:   2.2649                       
REMARK   3      S21:   1.6179 S22:   0.8375 S23:   1.4592                       
REMARK   3      S31:  -0.9497 S32:   1.5016 S33:   0.1620                       
REMARK   3   TLS GROUP : 43                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 68 THROUGH 75 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 250.0930-393.3316 278.7109              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3816 T22:   0.8585                                     
REMARK   3      T33:   1.1102 T12:  -0.3797                                     
REMARK   3      T13:   0.1928 T23:   0.1117                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.9101 L22:   9.1858                                     
REMARK   3      L33:   9.5316 L12:   7.9916                                     
REMARK   3      L13:   8.0676 L23:   7.7357                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.1828 S12:   0.7859 S13:   2.1641                       
REMARK   3      S21:  -1.0323 S22:   0.8842 S23:   1.8959                       
REMARK   3      S31:  -2.1477 S32:   0.2629 S33:   0.5058                       
REMARK   3   TLS GROUP : 44                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 76 THROUGH 84 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 264.6795-386.5760 285.4220              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4864 T22:   1.4677                                     
REMARK   3      T33:   1.0985 T12:  -0.7261                                     
REMARK   3      T13:   0.2251 T23:  -0.0635                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.4995 L22:   5.3452                                     
REMARK   3      L33:   3.8462 L12:  -6.1982                                     
REMARK   3      L13:  -3.7716 L23:   3.7371                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.2280 S12:   0.2294 S13:  -0.9173                       
REMARK   3      S21:   0.5979 S22:  -0.0905 S23:   0.2289                       
REMARK   3      S31:  -1.9858 S32:   2.0564 S33:   1.1864                       
REMARK   3   TLS GROUP : 45                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 85 THROUGH 90 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 259.0745-399.2782 276.4056              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2842 T22:   0.9424                                     
REMARK   3      T33:  -0.1084 T12:  -1.5160                                     
REMARK   3      T13:   1.3360 T23:   0.3919                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.7780 L22:   4.5172                                     
REMARK   3      L33:   0.0987 L12:   3.7170                                     
REMARK   3      L13:  -0.3612 L23:  -0.4318                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6884 S12:   0.1635 S13:   1.8853                       
REMARK   3      S21:   0.4465 S22:   0.1109 S23:   0.1661                       
REMARK   3      S31:  -1.3346 S32:   1.1650 S33:  -0.5529                       
REMARK   3   TLS GROUP : 46                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 91 THROUGH 103 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 254.7630-406.6362 272.7438              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9797 T22:   1.0051                                     
REMARK   3      T33:   0.5522 T12:  -0.4601                                     
REMARK   3      T13:   0.1813 T23:  -0.0899                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.4178 L22:   3.0396                                     
REMARK   3      L33:   0.8818 L12:   1.9619                                     
REMARK   3      L13:  -0.0567 L23:  -0.8140                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1660 S12:   0.2660 S13:  -0.0112                       
REMARK   3      S21:   0.0645 S22:   0.2165 S23:  -0.4951                       
REMARK   3      S31:  -0.9303 S32:   0.0601 S33:  -0.5088                       
REMARK   3   TLS GROUP : 47                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 104 THROUGH 108 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 267.0889-383.8980 276.2207              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.8106 T22:   1.2411                                     
REMARK   3      T33:   0.9193 T12:  -0.5696                                     
REMARK   3      T13:   0.3635 T23:  -0.3716                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.4481 L22:   1.9958                                     
REMARK   3      L33:   3.9341 L12:  -3.9932                                     
REMARK   3      L13:   2.4099 L23:  -6.5698                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.9644 S12:   0.7554 S13:  -0.6890                       
REMARK   3      S21:   2.2568 S22:  -0.9158 S23:  -1.1296                       
REMARK   3      S31:   1.7113 S32:  -1.4105 S33:  -0.3370                       
REMARK   3   TLS GROUP : 48                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 1 THROUGH 17 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 234.6101-390.1909 319.4458              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8736 T22:   0.3552                                     
REMARK   3      T33:   0.4719 T12:  -0.0932                                     
REMARK   3      T13:   0.1545 T23:   0.0469                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.8262 L22:   8.4096                                     
REMARK   3      L33:   3.0935 L12:  -3.6753                                     
REMARK   3      L13:   1.4376 L23:   2.8126                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2163 S12:  -0.3469 S13:   0.4557                       
REMARK   3      S21:   0.1177 S22:   0.2324 S23:   0.1998                       
REMARK   3      S31:  -0.8833 S32:   0.1212 S33:   0.2076                       
REMARK   3   TLS GROUP : 49                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 18 THROUGH 25 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 238.1685-393.2192 315.1974              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1959 T22:   0.2911                                     
REMARK   3      T33:   0.6282 T12:  -0.0545                                     
REMARK   3      T13:   0.1267 T23:   0.0107                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.7006 L22:   7.4409                                     
REMARK   3      L33:   0.2783 L12:  -6.4315                                     
REMARK   3      L13:  -1.2597 L23:   1.4084                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.5232 S12:  -0.4613 S13:  -0.0832                       
REMARK   3      S21:   0.3278 S22:   0.1115 S23:  -0.0031                       
REMARK   3      S31:  -1.0356 S32:   0.6215 S33:  -0.3665                       
REMARK   3   TLS GROUP : 50                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 26 THROUGH 39 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 236.1640-403.1344 314.0266              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6850 T22:   0.3514                                     
REMARK   3      T33:   0.3397 T12:  -0.0520                                     
REMARK   3      T13:  -0.0134 T23:  -0.0126                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.0713 L22:   2.8731                                     
REMARK   3      L33:   0.7514 L12:  -1.4453                                     
REMARK   3      L13:   0.7957 L23:  -0.2024                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3083 S12:   0.2780 S13:  -0.1617                       
REMARK   3      S21:   0.2298 S22:   0.1365 S23:  -0.0883                       
REMARK   3      S31:  -0.2631 S32:   0.0645 S33:   0.1724                       
REMARK   3   TLS GROUP : 51                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 40 THROUGH 51 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 224.7595-400.1124 317.9290              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7573 T22:   0.2880                                     
REMARK   3      T33:   0.4849 T12:   0.0176                                     
REMARK   3      T13:   0.0066 T23:   0.0303                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.5827 L22:   3.3568                                     
REMARK   3      L33:   3.4193 L12:   0.6158                                     
REMARK   3      L13:   0.7530 L23:   3.3860                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.5241 S12:   0.1450 S13:   0.4230                       
REMARK   3      S21:   0.2254 S22:  -0.3736 S23:   0.4903                       
REMARK   3      S31:  -0.6614 S32:  -0.8871 S33:   0.0676                       
REMARK   3   TLS GROUP : 52                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 52 THROUGH 60 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 231.6174-402.9388 303.5085              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8852 T22:   0.5124                                     
REMARK   3      T33:   0.4986 T12:  -0.0088                                     
REMARK   3      T13:  -0.1298 T23:   0.1207                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.7249 L22:   3.9780                                     
REMARK   3      L33:   2.9101 L12:  -1.6172                                     
REMARK   3      L13:  -4.0797 L23:   1.0413                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2889 S12:   1.4450 S13:   0.4728                       
REMARK   3      S21:  -1.0115 S22:   0.2397 S23:  -0.4921                       
REMARK   3      S31:  -0.0117 S32:  -0.7574 S33:  -0.0643                       
REMARK   3   TLS GROUP : 53                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 61 THROUGH 83 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 232.3505-394.5277 309.4351              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8893 T22:   0.3624                                     
REMARK   3      T33:   0.4969 T12:   0.0098                                     
REMARK   3      T13:   0.0616 T23:   0.0546                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.9696 L22:   4.2054                                     
REMARK   3      L33:   3.4005 L12:  -0.9050                                     
REMARK   3      L13:   0.3335 L23:  -0.6055                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1948 S12:   0.4306 S13:   0.4435                       
REMARK   3      S21:  -0.5188 S22:  -0.0989 S23:  -0.0526                       
REMARK   3      S31:  -0.6295 S32:  -0.0283 S33:  -0.0991                       
REMARK   3   TLS GROUP : 54                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 84 THROUGH 99 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 227.0350-394.1485 317.8202              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9206 T22:   0.4042                                     
REMARK   3      T33:   0.5386 T12:  -0.0720                                     
REMARK   3      T13:   0.0826 T23:   0.0283                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.0918 L22:   6.2033                                     
REMARK   3      L33:   6.3830 L12:  -7.2299                                     
REMARK   3      L13:  -4.5572 L23:   4.0243                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0918 S12:   0.3443 S13:  -0.1621                       
REMARK   3      S21:   0.4986 S22:  -0.2692 S23:   0.7232                       
REMARK   3      S31:  -0.5821 S32:  -0.4205 S33:   0.1233                       
REMARK   3   TLS GROUP : 55                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 100 THROUGH 119 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 231.4120-411.0244 312.9409              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6417 T22:   0.3113                                     
REMARK   3      T33:   0.3610 T12:   0.0064                                     
REMARK   3      T13:   0.0104 T23:   0.0474                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.2118 L22:   5.2245                                     
REMARK   3      L33:   9.4891 L12:   4.4453                                     
REMARK   3      L13:   4.4479 L23:   6.2187                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1148 S12:   0.3481 S13:   0.0467                       
REMARK   3      S21:   0.4771 S22:  -0.0117 S23:   0.1158                       
REMARK   3      S31:   0.4014 S32:   0.6034 S33:   0.0932                       
REMARK   3   TLS GROUP : 56                                                     
REMARK   3    SELECTION: CHAIN 'G' AND (RESID 120 THROUGH 126 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 226.5169-386.3115 323.5951              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.6552 T22:  -0.1909                                     
REMARK   3      T33:   0.5641 T12:  -0.0622                                     
REMARK   3      T13:   0.2916 T23:  -0.2900                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1555 L22:   0.5420                                     
REMARK   3      L33:   0.5339 L12:  -1.1672                                     
REMARK   3      L13:  -0.6870 L23:   0.0756                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3287 S12:  -0.1434 S13:   0.7598                       
REMARK   3      S21:   0.3244 S22:  -0.2272 S23:   0.4701                       
REMARK   3      S31:   0.5086 S32:  -0.3593 S33:   1.2842                       
REMARK   3   TLS GROUP : 57                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 1 THROUGH 39 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 246.7662-450.1462 317.3106              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6797 T22:   0.4572                                     
REMARK   3      T33:   0.5276 T12:   0.0822                                     
REMARK   3      T13:  -0.0035 T23:  -0.0648                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.8175 L22:   8.2319                                     
REMARK   3      L33:   3.9412 L12:   2.0131                                     
REMARK   3      L13:   0.0415 L23:  -1.2558                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0809 S12:  -0.1089 S13:   0.0586                       
REMARK   3      S21:   0.9458 S22:  -0.1963 S23:  -0.0068                       
REMARK   3      S31:   0.0754 S32:   0.2429 S33:   0.1027                       
REMARK   3   TLS GROUP : 58                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 40 THROUGH 51 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 245.0481-457.4245 307.9266              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0680 T22:   0.5817                                     
REMARK   3      T33:   0.7327 T12:  -0.0545                                     
REMARK   3      T13:  -0.0298 T23:  -0.1934                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.0829 L22:   9.1954                                     
REMARK   3      L33:   5.7615 L12:  -6.2408                                     
REMARK   3      L13:   5.3482 L23:  -6.7677                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.5829 S12:   0.3941 S13:  -1.3862                       
REMARK   3      S21:  -1.0620 S22:   0.3248 S23:   1.6705                       
REMARK   3      S31:   0.6734 S32:   1.1002 S33:  -0.5650                       
REMARK   3   TLS GROUP : 59                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 52 THROUGH 60 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 237.0377-443.3665 307.9345              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6566 T22:   0.5085                                     
REMARK   3      T33:   0.6667 T12:  -0.1125                                     
REMARK   3      T13:   0.1467 T23:   0.0904                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.1430 L22:   4.4342                                     
REMARK   3      L33:   9.4866 L12:   5.2479                                     
REMARK   3      L13:   7.6968 L23:   6.4677                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.0799 S12:   1.1425 S13:   0.7757                       
REMARK   3      S21:  -0.8458 S22:   0.7144 S23:  -0.0150                       
REMARK   3      S31:  -0.7327 S32:   0.2869 S33:   0.3220                       
REMARK   3   TLS GROUP : 60                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 61 THROUGH 83 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 238.9566-449.6571 315.7733              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6651 T22:   0.3724                                     
REMARK   3      T33:   0.6150 T12:   0.0723                                     
REMARK   3      T13:   0.2060 T23:  -0.0155                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.4502 L22:   6.6592                                     
REMARK   3      L33:   8.4612 L12:   2.7420                                     
REMARK   3      L13:   1.2721 L23:  -1.3370                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4269 S12:  -0.5085 S13:   0.0744                       
REMARK   3      S21:   1.5066 S22:  -0.2977 S23:   0.4240                       
REMARK   3      S31:   0.4287 S32:  -0.2909 S33:  -0.1110                       
REMARK   3   TLS GROUP : 61                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 84 THROUGH 99 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 243.6171-458.2032 314.2169              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0090 T22:   0.4398                                     
REMARK   3      T33:   0.6683 T12:   0.0730                                     
REMARK   3      T13:   0.1100 T23:  -0.0607                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.3967 L22:   9.0327                                     
REMARK   3      L33:   9.5087 L12:   7.1659                                     
REMARK   3      L13:  -4.7662 L23:  -8.6296                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1143 S12:   0.4477 S13:  -0.5927                       
REMARK   3      S21:   0.7748 S22:   0.3594 S23:   0.4048                       
REMARK   3      S31:   0.6770 S32:  -0.2767 S33:  -0.5190                       
REMARK   3   TLS GROUP : 62                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 100 THROUGH 109 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 242.7082-442.7447 297.5738              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6726 T22:   0.5962                                     
REMARK   3      T33:   0.4283 T12:  -0.0771                                     
REMARK   3      T13:   0.0394 T23:   0.0237                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.8473 L22:   6.4694                                     
REMARK   3      L33:   2.1574 L12:   0.9150                                     
REMARK   3      L13:  -2.5090 L23:   0.9092                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.8509 S12:  -0.4443 S13:  -0.1342                       
REMARK   3      S21:   1.1695 S22:  -0.5975 S23:   0.1995                       
REMARK   3      S31:   0.3169 S32:   0.3207 S33:  -0.0723                       
REMARK   3   TLS GROUP : 63                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 110 THROUGH 119 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 252.2898-447.3249 306.2746              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5709 T22:   0.5685                                     
REMARK   3      T33:   0.5216 T12:  -0.2181                                     
REMARK   3      T13:   0.0533 T23:  -0.1447                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.6890 L22:   3.8202                                     
REMARK   3      L33:   2.9380 L12:  -4.2131                                     
REMARK   3      L13:   2.1024 L23:   0.0724                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2121 S12:   0.5321 S13:   0.4081                       
REMARK   3      S21:  -0.1319 S22:  -0.7013 S23:  -0.4427                       
REMARK   3      S31:   0.5653 S32:   2.2547 S33:   0.6697                       
REMARK   3   TLS GROUP : 64                                                     
REMARK   3    SELECTION: CHAIN 'H' AND (RESID 120 THROUGH 126 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 245.1206-464.8290 321.2458              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1951 T22:   0.4523                                     
REMARK   3      T33:   0.7092 T12:  -0.0402                                     
REMARK   3      T13:   0.1596 T23:   0.0372                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.8260 L22:   4.3722                                     
REMARK   3      L33:   4.0568 L12:   5.4568                                     
REMARK   3      L13:  -3.6616 L23:  -2.5912                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1846 S12:  -0.3989 S13:  -1.0672                       
REMARK   3      S21:   1.7500 S22:  -1.6349 S23:  -1.1510                       
REMARK   3      S31:   1.0900 S32:   0.3337 S33:   1.2783                       
REMARK   3   TLS GROUP : 65                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 1 THROUGH 39 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 270.8801-415.9757 279.5179              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8012 T22:   1.3966                                     
REMARK   3      T33:   0.6632 T12:  -0.5100                                     
REMARK   3      T13:   0.1145 T23:  -0.2241                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.8684 L22:   2.5507                                     
REMARK   3      L33:   2.2224 L12:  -0.9752                                     
REMARK   3      L13:   2.5145 L23:  -0.8112                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3818 S12:  -0.7785 S13:  -0.2762                       
REMARK   3      S21:  -0.2907 S22:   0.1885 S23:  -0.8021                       
REMARK   3      S31:  -0.2330 S32:   1.3945 S33:  -0.5704                       
REMARK   3   TLS GROUP : 66                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 40 THROUGH 51 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 264.2452-409.1569 272.1646              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9806 T22:   1.0943                                     
REMARK   3      T33:   0.4748 T12:  -0.3973                                     
REMARK   3      T13:   0.1566 T23:  -0.1141                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.0319 L22:   5.9583                                     
REMARK   3      L33:   3.7947 L12:  -1.6343                                     
REMARK   3      L13:   2.8720 L23:   2.5036                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0573 S12:   0.6790 S13:   0.4494                       
REMARK   3      S21:  -0.8164 S22:   0.0593 S23:  -0.4780                       
REMARK   3      S31:  -0.1901 S32:   0.0522 S33:   0.0190                       
REMARK   3   TLS GROUP : 67                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 52 THROUGH 60 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 257.1669-422.3345 278.0501              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8612 T22:   1.1905                                     
REMARK   3      T33:   0.6322 T12:  -0.3653                                     
REMARK   3      T13:   0.0842 T23:  -0.1758                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.4039 L22:   3.5224                                     
REMARK   3      L33:   6.3251 L12:   1.0716                                     
REMARK   3      L13:  -2.4692 L23:  -4.6631                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2989 S12:  -0.5759 S13:  -0.8138                       
REMARK   3      S21:  -0.2821 S22:  -0.2136 S23:   0.4465                       
REMARK   3      S31:   0.6016 S32:  -0.1424 S33:  -0.2957                       
REMARK   3   TLS GROUP : 68                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 61 THROUGH 73 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 264.3892-419.9130 270.6224              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8618 T22:   1.2192                                     
REMARK   3      T33:   0.7212 T12:  -0.4843                                     
REMARK   3      T13:   0.1839 T23:  -0.1718                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.6759 L22:   8.4878                                     
REMARK   3      L33:   7.9618 L12:  -4.2210                                     
REMARK   3      L13:   3.2005 L23:   0.1771                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1041 S12:   0.8566 S13:  -1.0861                       
REMARK   3      S21:  -1.2583 S22:   0.3972 S23:   0.4960                       
REMARK   3      S31:   0.3809 S32:  -0.7450 S33:  -0.2866                       
REMARK   3   TLS GROUP : 69                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 74 THROUGH 83 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 270.0142-422.8430 280.4510              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7901 T22:   1.1717                                     
REMARK   3      T33:   0.5561 T12:  -0.2460                                     
REMARK   3      T13:   0.0203 T23:  -0.1442                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.0414 L22:   9.4110                                     
REMARK   3      L33:   2.5698 L12:  -1.5518                                     
REMARK   3      L13:  -3.2866 L23:  -2.9353                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.5402 S12:  -1.4213 S13:  -0.7310                       
REMARK   3      S21:  -0.4684 S22:   0.6365 S23:   0.2864                       
REMARK   3      S31:  -0.2898 S32:   1.6063 S33:  -1.1488                       
REMARK   3   TLS GROUP : 70                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 84 THROUGH 99 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 269.6105-412.3257 271.1754              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9403 T22:   1.4256                                     
REMARK   3      T33:   0.5799 T12:  -0.5560                                     
REMARK   3      T13:   0.1362 T23:  -0.1245                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.9821 L22:   8.0755                                     
REMARK   3      L33:   4.6901 L12:   0.3614                                     
REMARK   3      L13:  -4.9138 L23:   3.0429                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0766 S12:  -0.0109 S13:   0.2025                       
REMARK   3      S21:  -1.1170 S22:   0.4643 S23:  -0.2772                       
REMARK   3      S31:  -0.6023 S32:  -0.1745 S33:  -0.5917                       
REMARK   3   TLS GROUP : 71                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 100 THROUGH 109 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 249.6335-414.0030 281.4413              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5429 T22:   0.7983                                     
REMARK   3      T33:   0.5446 T12:  -0.2703                                     
REMARK   3      T13:   0.0648 T23:   0.0112                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.7479 L22:   6.4052                                     
REMARK   3      L33:   1.0628 L12:  -0.0652                                     
REMARK   3      L13:  -2.3334 L23:   0.8296                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1666 S12:  -0.3443 S13:  -0.9308                       
REMARK   3      S21:  -1.0827 S22:   0.5656 S23:  -0.2735                       
REMARK   3      S31:  -0.9248 S32:   1.3973 S33:  -0.7171                       
REMARK   3   TLS GROUP : 72                                                     
REMARK   3    SELECTION: CHAIN 'I' AND (RESID 110 THROUGH 125 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 267.1878-409.2550 279.0724              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8623 T22:   1.3991                                     
REMARK   3      T33:   0.7480 T12:  -0.6242                                     
REMARK   3      T13:   0.1639 T23:  -0.4226                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9213 L22:   0.8885                                     
REMARK   3      L33:   0.1693 L12:  -0.8716                                     
REMARK   3      L13:   0.3858 L23:  -0.4035                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.1093 S12:  -1.0312 S13:   0.6694                       
REMARK   3      S21:  -0.1333 S22:  -0.4169 S23:  -0.6233                       
REMARK   3      S31:  -0.7359 S32:   0.9182 S33:  -0.1201                       
REMARK   3   TLS GROUP : 73                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 6 THROUGH 22 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 224.4792-428.7090 250.7685              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0716 T22:   1.5652                                     
REMARK   3      T33:   0.7668 T12:   0.1761                                     
REMARK   3      T13:   0.2334 T23:  -0.3688                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.8613 L22:   8.2503                                     
REMARK   3      L33:   8.6012 L12:   4.5388                                     
REMARK   3      L13:  -1.8512 L23:  -0.0458                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.5002 S12:  -4.2637 S13:   1.2598                       
REMARK   3      S21:   1.3358 S22:   0.5240 S23:   1.2243                       
REMARK   3      S31:  -2.2835 S32:  -0.5785 S33:   0.5836                       
REMARK   3   TLS GROUP : 74                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 23 THROUGH 44 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 228.7994-434.7847 252.4536              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1322 T22:   1.5814                                     
REMARK   3      T33:   0.6646 T12:  -0.1472                                     
REMARK   3      T13:   0.2673 T23:  -0.0080                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.7603 L22:   5.3638                                     
REMARK   3      L33:   4.9677 L12:  -0.8468                                     
REMARK   3      L13:   2.6973 L23:  -3.8982                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1383 S12:  -2.1862 S13:   0.1695                       
REMARK   3      S21:   0.5373 S22:  -0.3790 S23:   0.1099                       
REMARK   3      S31:  -0.3927 S32:   0.9107 S33:   0.3331                       
REMARK   3   TLS GROUP : 75                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 45 THROUGH 67 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 228.5775-434.2531 242.4701              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5935 T22:   0.6393                                     
REMARK   3      T33:   0.5782 T12:  -0.0170                                     
REMARK   3      T13:   0.1146 T23:   0.0162                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3652 L22:   2.9839                                     
REMARK   3      L33:   2.2229 L12:  -2.2728                                     
REMARK   3      L13:  -0.9335 L23:  -0.0484                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2221 S12:  -0.5389 S13:  -0.9730                       
REMARK   3      S21:   0.2027 S22:  -0.0055 S23:   0.7544                       
REMARK   3      S31:   0.3784 S32:  -0.4779 S33:   0.1853                       
REMARK   3   TLS GROUP : 76                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 68 THROUGH 75 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 252.7840-439.8536 234.0893              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8322 T22:   0.8926                                     
REMARK   3      T33:   0.4848 T12:   0.2195                                     
REMARK   3      T13:   0.0869 T23:   0.0995                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.3214 L22:  -0.0021                                     
REMARK   3      L33:   0.6441 L12:  -0.1262                                     
REMARK   3      L13:   2.4716 L23:  -0.0161                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6268 S12:   1.1688 S13:  -0.3833                       
REMARK   3      S21:   0.2800 S22:   0.2570 S23:   0.7215                       
REMARK   3      S31:   0.4855 S32:   1.2934 S33:   0.2478                       
REMARK   3   TLS GROUP : 77                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 76 THROUGH 98 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 228.5716-441.9282 235.7763              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8651 T22:   0.6856                                     
REMARK   3      T33:   0.8988 T12:  -0.0353                                     
REMARK   3      T13:   0.1273 T23:  -0.0764                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1943 L22:   4.8931                                     
REMARK   3      L33:   6.2668 L12:  -1.0250                                     
REMARK   3      L13:  -0.5708 L23:   0.1298                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2223 S12:  -0.7131 S13:  -1.9099                       
REMARK   3      S21:  -0.2265 S22:  -0.5574 S23:   0.8837                       
REMARK   3      S31:   1.4841 S32:  -0.3931 S33:   0.6202                       
REMARK   3   TLS GROUP : 78                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 99 THROUGH 112 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 259.2186-434.0368 234.2178              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6276 T22:   0.8733                                     
REMARK   3      T33:   0.6941 T12:   0.1382                                     
REMARK   3      T13:  -0.0295 T23:   0.0911                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1546 L22:   4.6144                                     
REMARK   3      L33:   4.5668 L12:  -0.8123                                     
REMARK   3      L13:  -0.3257 L23:   1.5088                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2015 S12:   0.8881 S13:   0.0292                       
REMARK   3      S21:  -0.1515 S22:  -0.2151 S23:  -1.0382                       
REMARK   3      S31:   0.2675 S32:   0.3575 S33:   0.3513                       
REMARK   3   TLS GROUP : 79                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 113 THROUGH 126 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 235.0161-430.5747 236.6962              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5478 T22:   0.5640                                     
REMARK   3      T33:   0.4035 T12:   0.0824                                     
REMARK   3      T13:   0.1585 T23:   0.0464                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.8724 L22:   1.6106                                     
REMARK   3      L33:   2.2349 L12:  -1.7297                                     
REMARK   3      L13:   2.2267 L23:   0.0818                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2833 S12:   0.0008 S13:   0.0160                       
REMARK   3      S21:  -0.0126 S22:  -0.3192 S23:   0.1941                       
REMARK   3      S31:   0.4275 S32:  -0.0737 S33:   0.0963                       
REMARK   3   TLS GROUP : 80                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 127 THROUGH 136 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 223.6356-441.1136 241.6915              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9070 T22:   0.7877                                     
REMARK   3      T33:   0.8915 T12:  -0.1003                                     
REMARK   3      T13:   0.1670 T23:   0.0145                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6139 L22:   5.3932                                     
REMARK   3      L33:   3.0518 L12:   2.9319                                     
REMARK   3      L13:  -2.0968 L23:  -0.6221                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6967 S12:  -1.0919 S13:  -1.6903                       
REMARK   3      S21:  -0.5601 S22:  -0.0760 S23:   0.5943                       
REMARK   3      S31:   0.2729 S32:  -0.5509 S33:   0.6358                       
REMARK   3   TLS GROUP : 81                                                     
REMARK   3    SELECTION: CHAIN 'J' AND (RESID 137 THROUGH 158 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 235.9016-431.9113 244.3114              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6919 T22:   0.7354                                     
REMARK   3      T33:   0.4509 T12:   0.0273                                     
REMARK   3      T13:   0.2320 T23:   0.0055                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.0399 L22:   3.8959                                     
REMARK   3      L33:   2.2653 L12:  -1.9459                                     
REMARK   3      L13:   1.5074 L23:  -0.1639                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0406 S12:  -1.2183 S13:   0.4641                       
REMARK   3      S21:   0.6031 S22:  -0.1418 S23:   0.1331                       
REMARK   3      S31:   0.2679 S32:  -0.2645 S33:   0.1069                       
REMARK   3   TLS GROUP : 82                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 6 THROUGH 22 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 217.0430-431.8507 226.9128              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9386 T22:   0.6729                                     
REMARK   3      T33:   1.1044 T12:  -0.1058                                     
REMARK   3      T13:   0.2623 T23:  -0.0562                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.8803 L22:   6.8790                                     
REMARK   3      L33:   7.0613 L12:   2.3869                                     
REMARK   3      L13:   6.2344 L23:  -0.7975                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -2.8869 S12:  -1.5803 S13:  -2.3048                       
REMARK   3      S21:   0.7989 S22:   0.7284 S23:   2.8602                       
REMARK   3      S31:   0.6038 S32:  -0.3563 S33:   2.1839                       
REMARK   3   TLS GROUP : 83                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 23 THROUGH 32 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 225.3942-435.1562 217.0609              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8643 T22:   0.9826                                     
REMARK   3      T33:   1.0828 T12:   0.0878                                     
REMARK   3      T13:   0.0230 T23:  -0.3083                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.9946 L22:   7.0248                                     
REMARK   3      L33:   5.3016 L12:  -3.9237                                     
REMARK   3      L13:  -0.8861 L23:   4.3346                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6142 S12:   2.0201 S13:  -1.9887                       
REMARK   3      S21:   0.4878 S22:  -1.2029 S23:   1.2843                       
REMARK   3      S31:   0.8356 S32:  -1.2282 S33:   0.8168                       
REMARK   3   TLS GROUP : 84                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 33 THROUGH 53 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 215.9889-426.3805 221.5049              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5761 T22:   1.3265                                     
REMARK   3      T33:   0.8725 T12:   0.1048                                     
REMARK   3      T13:  -0.0670 T23:  -0.3648                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.7892 L22:   9.8167                                     
REMARK   3      L33:   8.1009 L12:  -6.2095                                     
REMARK   3      L13:   1.5408 L23:  -2.0801                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0241 S12:   0.1715 S13:  -0.7005                       
REMARK   3      S21:  -0.9829 S22:  -0.3449 S23:   1.9853                       
REMARK   3      S31:   0.4364 S32:  -0.5932 S33:   0.3234                       
REMARK   3   TLS GROUP : 85                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 54 THROUGH 67 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 230.5099-427.1732 226.5445              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6644 T22:   0.6207                                     
REMARK   3      T33:   0.5706 T12:   0.1860                                     
REMARK   3      T13:   0.0849 T23:  -0.0348                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.4571 L22:   4.7903                                     
REMARK   3      L33:   4.4567 L12:  -3.7895                                     
REMARK   3      L13:  -3.5457 L23:   4.1999                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.9754 S12:   0.8232 S13:  -0.4499                       
REMARK   3      S21:   0.9429 S22:  -0.0149 S23:   0.6938                       
REMARK   3      S31:   0.3100 S32:  -0.6647 S33:   1.1837                       
REMARK   3   TLS GROUP : 86                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 68 THROUGH 75 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 250.5374-427.1829 216.8124              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8841 T22:   0.4381                                     
REMARK   3      T33:   0.7473 T12:   0.0390                                     
REMARK   3      T13:   0.0921 T23:  -0.0588                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.6348 L22:   5.7073                                     
REMARK   3      L33:   5.8379 L12:  -6.5820                                     
REMARK   3      L13:  -6.5121 L23:   5.7207                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1460 S12:  -0.2975 S13:   1.9817                       
REMARK   3      S21:   1.4937 S22:   0.7140 S23:  -1.7529                       
REMARK   3      S31:  -0.4707 S32:   0.0902 S33:  -0.9039                       
REMARK   3   TLS GROUP : 87                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 76 THROUGH 98 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 228.6729-416.3637 219.8904              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8665 T22:   0.6815                                     
REMARK   3      T33:   0.6133 T12:   0.1637                                     
REMARK   3      T13:   0.0025 T23:  -0.0096                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.4100 L22:   5.9960                                     
REMARK   3      L33:   3.9978 L12:  -1.3266                                     
REMARK   3      L13:  -3.4064 L23:   1.9549                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2022 S12:   1.1550 S13:   0.5743                       
REMARK   3      S21:  -0.9738 S22:  -0.3581 S23:   0.7294                       
REMARK   3      S31:  -0.4245 S32:  -0.5499 S33:   0.2122                       
REMARK   3   TLS GROUP : 88                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 99 THROUGH 112 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 255.8266-432.8781 220.6427              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7619 T22:   0.6041                                     
REMARK   3      T33:   0.7737 T12:   0.0721                                     
REMARK   3      T13:   0.0125 T23:  -0.0882                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.0008 L22:   9.6242                                     
REMARK   3      L33:   8.3612 L12:  -6.8243                                     
REMARK   3      L13:  -6.5590 L23:   5.9302                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6004 S12:  -0.9580 S13:   0.9131                       
REMARK   3      S21:   0.7140 S22:   0.7611 S23:  -0.2984                       
REMARK   3      S31:   0.1672 S32:   0.5558 S33:  -0.2842                       
REMARK   3   TLS GROUP : 89                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 113 THROUGH 126 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 233.6526-425.0569 227.9611              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6428 T22:   0.5502                                     
REMARK   3      T33:   0.4895 T12:   0.1083                                     
REMARK   3      T13:   0.1047 T23:  -0.0936                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.0431 L22:   4.3050                                     
REMARK   3      L33:   5.4301 L12:  -5.5927                                     
REMARK   3      L13:  -6.0971 L23:   4.8621                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0588 S12:  -0.5616 S13:  -0.2407                       
REMARK   3      S21:  -0.3297 S22:   0.0345 S23:   0.2453                       
REMARK   3      S31:   0.2401 S32:  -0.2803 S33:   0.0011                       
REMARK   3   TLS GROUP : 90                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 127 THROUGH 150 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 230.2110-427.9710 219.9453              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6911 T22:   0.6187                                     
REMARK   3      T33:   0.4525 T12:   0.0238                                     
REMARK   3      T13:  -0.0838 T23:  -0.1287                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.2642 L22:   4.5663                                     
REMARK   3      L33:   3.3124 L12:  -2.9274                                     
REMARK   3      L13:  -2.9313 L23:   1.8145                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0042 S12:   0.4949 S13:   0.0467                       
REMARK   3      S21:  -0.5662 S22:  -0.4191 S23:   0.5308                       
REMARK   3      S31:   0.2716 S32:  -0.9295 S33:   0.3649                       
REMARK   3   TLS GROUP : 91                                                     
REMARK   3    SELECTION: CHAIN 'K' AND (RESID 151 THROUGH 158 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 220.4042-424.3588 229.5475              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6336 T22:   0.8072                                     
REMARK   3      T33:   0.7603 T12:   0.1552                                     
REMARK   3      T13:   0.0635 T23:  -0.1188                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.4236 L22:   8.6148                                     
REMARK   3      L33:   3.8302 L12:  -0.8827                                     
REMARK   3      L13:  -3.2633 L23:   3.2239                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.5921 S12:   1.1583 S13:   0.1816                       
REMARK   3      S21:   0.1910 S22:  -1.0940 S23:   0.8365                       
REMARK   3      S31:  -0.5610 S32:  -1.5284 S33:   0.4965                       
REMARK   3   TLS GROUP : 92                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 6 THROUGH 32 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 228.1681-406.3074 233.6980              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9664 T22:   0.6579                                     
REMARK   3      T33:   0.9646 T12:   0.2066                                     
REMARK   3      T13:   0.0841 T23:   0.0736                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.0188 L22:   5.8540                                     
REMARK   3      L33:   6.9568 L12:   5.9390                                     
REMARK   3      L13:  -6.0521 L23:  -3.7098                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1821 S12:   1.2369 S13:   1.8091                       
REMARK   3      S21:  -0.4320 S22:   0.6398 S23:   1.0311                       
REMARK   3      S31:   0.0517 S32:  -0.9370 S33:  -0.3973                       
REMARK   3   TLS GROUP : 93                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 33 THROUGH 53 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 224.7275-406.7312 242.0215              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6918 T22:   0.6725                                     
REMARK   3      T33:   0.7314 T12:   0.0979                                     
REMARK   3      T13:   0.2469 T23:  -0.1227                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.3356 L22:   7.1734                                     
REMARK   3      L33:   8.0313 L12:  -3.5249                                     
REMARK   3      L13:   0.8085 L23:   0.5482                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1232 S12:  -0.5812 S13:   0.3371                       
REMARK   3      S21:   0.6239 S22:   0.0953 S23:   0.7325                       
REMARK   3      S31:  -0.4351 S32:  -0.5044 S33:   0.0748                       
REMARK   3   TLS GROUP : 94                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 54 THROUGH 126 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 242.7537-417.9488 238.7804              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7737 T22:   0.6205                                     
REMARK   3      T33:   0.3914 T12:   0.1497                                     
REMARK   3      T13:   0.0657 T23:   0.0656                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.1725 L22:   2.3568                                     
REMARK   3      L33:   3.4782 L12:   1.0238                                     
REMARK   3      L13:  -2.8474 L23:  -0.4197                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3018 S12:  -1.0412 S13:  -0.4035                       
REMARK   3      S21:   0.5749 S22:  -0.0573 S23:  -0.0652                       
REMARK   3      S31:   0.3030 S32:   0.3091 S33:   0.3723                       
REMARK   3   TLS GROUP : 95                                                     
REMARK   3    SELECTION: CHAIN 'L' AND (RESID 127 THROUGH 158 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 234.7351-412.3135 238.4283              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7862 T22:   0.4732                                     
REMARK   3      T33:   0.4398 T12:   0.1896                                     
REMARK   3      T13:   0.1084 T23:   0.0727                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.0469 L22:   1.7128                                     
REMARK   3      L33:   4.5724 L12:   0.7752                                     
REMARK   3      L13:  -2.5473 L23:   1.4300                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2425 S12:  -0.4664 S13:   0.3958                       
REMARK   3      S21:   0.3267 S22:   0.1898 S23:   0.2312                       
REMARK   3      S31:  -0.0700 S32:  -0.3359 S33:  -0.0060                       
REMARK   3   TLS GROUP : 96                                                     
REMARK   3    SELECTION: CHAIN 'M' AND (RESID 1 THROUGH 7 )                     
REMARK   3    ORIGIN FOR THE GROUP (A): 238.4438-441.2919 196.4952              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6081 T22:   0.5680                                     
REMARK   3      T33:   0.5927 T12:  -0.1977                                     
REMARK   3      T13:   0.0626 T23:  -0.1203                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.5949 L22:   8.5790                                     
REMARK   3      L33:   3.0139 L12:   4.1575                                     
REMARK   3      L13:  -3.2335 L23:  -4.9282                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1280 S12:   0.7622 S13:  -0.4761                       
REMARK   3      S21:   0.2034 S22:  -0.1990 S23:   0.1155                       
REMARK   3      S31:  -1.8123 S32:   0.1584 S33:  -0.1331                       
REMARK   3   TLS GROUP : 97                                                     
REMARK   3    SELECTION: CHAIN 'M' AND (RESID 8 THROUGH 18 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 252.4264-435.6029 180.9932              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8777 T22:   0.6353                                     
REMARK   3      T33:   0.5043 T12:  -0.0704                                     
REMARK   3      T13:   0.0059 T23:   0.1194                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.7017 L22:   4.7963                                     
REMARK   3      L33:   6.3159 L12:   3.3458                                     
REMARK   3      L13:  -5.9419 L23:  -4.6975                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.3542 S12:   2.2175 S13:  -0.0772                       
REMARK   3      S21:  -1.3816 S22:   0.9503 S23:  -0.1603                       
REMARK   3      S31:   1.0876 S32:  -0.5365 S33:   0.4480                       
REMARK   3   TLS GROUP : 98                                                     
REMARK   3    SELECTION: CHAIN 'M' AND (RESID 19 THROUGH 25 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 244.2118-434.6804 190.9720              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9255 T22:   0.5187                                     
REMARK   3      T33:   0.4979 T12:  -0.0415                                     
REMARK   3      T13:  -0.0922 T23:  -0.0902                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.5438 L22:   4.2782                                     
REMARK   3      L33:   5.8496 L12:   3.1817                                     
REMARK   3      L13:  -0.9945 L23:  -4.0885                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.8183 S12:   0.4553 S13:   0.9927                       
REMARK   3      S21:  -1.2021 S22:   0.0923 S23:   0.6567                       
REMARK   3      S31:  -0.8584 S32:  -0.7216 S33:   0.6172                       
REMARK   3   TLS GROUP : 99                                                     
REMARK   3    SELECTION: CHAIN 'M' AND (RESID 26 THROUGH 38 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 245.7216-437.0987 200.9818              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7176 T22:   0.2699                                     
REMARK   3      T33:   0.3635 T12:  -0.0014                                     
REMARK   3      T13:   0.0558 T23:   0.0105                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.6871 L22:   1.0407                                     
REMARK   3      L33:   8.2473 L12:  -0.8458                                     
REMARK   3      L13:  -6.0320 L23:   1.8282                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0070 S12:   0.3494 S13:   0.1477                       
REMARK   3      S21:  -0.0446 S22:   0.0771 S23:   0.3584                       
REMARK   3      S31:   0.0581 S32:  -0.5771 S33:  -0.0703                       
REMARK   3   TLS GROUP : 100                                                    
REMARK   3    SELECTION: CHAIN 'M' AND (RESID 39 THROUGH 48 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 258.7769-443.3554 195.6767              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8439 T22:   0.5663                                     
REMARK   3      T33:   0.4752 T12:   0.1517                                     
REMARK   3      T13:   0.1378 T23:   0.1064                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.6688 L22:   1.2572                                     
REMARK   3      L33:   4.3965 L12:   3.2394                                     
REMARK   3      L13:   6.1660 L23:   2.2919                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.2214 S12:   1.3498 S13:   0.3669                       
REMARK   3      S21:  -0.4880 S22:  -0.7900 S23:  -1.4232                       
REMARK   3      S31:   0.7733 S32:   1.7572 S33:  -0.3772                       
REMARK   3   TLS GROUP : 101                                                    
REMARK   3    SELECTION: CHAIN 'M' AND (RESID 49 THROUGH 67 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 255.7135-431.1843 198.4645              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6589 T22:   0.3373                                     
REMARK   3      T33:   0.3545 T12:   0.0105                                     
REMARK   3      T13:   0.0265 T23:   0.0530                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.0974 L22:   5.5959                                     
REMARK   3      L33:   5.3514 L12:  -3.7912                                     
REMARK   3      L13:  -3.8340 L23:   5.4612                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3860 S12:  -0.3968 S13:   0.1993                       
REMARK   3      S21:   0.4182 S22:   0.3306 S23:  -0.0112                       
REMARK   3      S31:   0.4304 S32:   0.2720 S33:   0.0327                       
REMARK   3   TLS GROUP : 102                                                    
REMARK   3    SELECTION: CHAIN 'M' AND (RESID 68 THROUGH 84 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 253.7353-434.1718 189.3900              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7120 T22:   0.4163                                     
REMARK   3      T33:   0.2976 T12:   0.0143                                     
REMARK   3      T13:   0.0222 T23:  -0.0360                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.6174 L22:   4.5521                                     
REMARK   3      L33:   5.2149 L12:  -0.8523                                     
REMARK   3      L13:  -4.1754 L23:   0.6638                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5277 S12:   0.1450 S13:   0.6766                       
REMARK   3      S21:  -0.2455 S22:   0.4519 S23:  -0.4399                       
REMARK   3      S31:   0.3152 S32:  -0.1950 S33:   0.2552                       
REMARK   3   TLS GROUP : 103                                                    
REMARK   3    SELECTION: CHAIN 'M' AND (RESID 85 THROUGH 103 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 245.1833-442.9054 200.6290              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6933 T22:   0.3227                                     
REMARK   3      T33:   0.3868 T12:  -0.0736                                     
REMARK   3      T13:   0.0544 T23:  -0.0104                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.1844 L22:   6.6305                                     
REMARK   3      L33:   3.8888 L12:  -5.1454                                     
REMARK   3      L13:  -1.6099 L23:   2.9902                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5112 S12:   0.0462 S13:  -0.6244                       
REMARK   3      S21:   0.2294 S22:  -0.0035 S23:   0.7088                       
REMARK   3      S31:   0.8386 S32:  -0.2733 S33:   0.7108                       
REMARK   3   TLS GROUP : 104                                                    
REMARK   3    SELECTION: CHAIN 'M' AND (RESID 104 THROUGH 108 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 253.9364-441.5287 180.1057              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0401 T22:   0.4878                                     
REMARK   3      T33:   0.6011 T12:   0.0021                                     
REMARK   3      T13:  -0.0017 T23:  -0.1063                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3887 L22:   1.7580                                     
REMARK   3      L33:   5.1543 L12:  -0.6703                                     
REMARK   3      L13:   2.7524 L23:  -2.5456                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6091 S12:   0.5572 S13:  -1.8643                       
REMARK   3      S21:   0.7120 S22:  -0.7129 S23:  -0.8021                       
REMARK   3      S31:   2.5206 S32:   0.6022 S33:   0.0764                       
REMARK   3   TLS GROUP : 105                                                    
REMARK   3    SELECTION: CHAIN 'N' AND (RESID 1 THROUGH 7 )                     
REMARK   3    ORIGIN FOR THE GROUP (A): 256.4658-390.3985 233.4875              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7254 T22:   0.7152                                     
REMARK   3      T33:   0.6463 T12:   0.0624                                     
REMARK   3      T13:   0.0980 T23:  -0.0982                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.0079 L22:   2.2710                                     
REMARK   3      L33:   3.7172 L12:   1.3612                                     
REMARK   3      L13:   3.7903 L23:   0.8660                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3972 S12:  -1.3527 S13:  -0.0400                       
REMARK   3      S21:   0.6769 S22:   0.1032 S23:  -0.3842                       
REMARK   3      S31:   0.3465 S32:   0.0105 S33:   0.3932                       
REMARK   3   TLS GROUP : 106                                                    
REMARK   3    SELECTION: CHAIN 'N' AND (RESID 8 THROUGH 25 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 271.7300-388.2567 240.7963              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.5632 T22:   1.1002                                     
REMARK   3      T33:   1.0581 T12:   0.2116                                     
REMARK   3      T13:  -0.3473 T23:  -0.4380                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.2768 L22:   7.0075                                     
REMARK   3      L33:   5.6962 L12:  -0.1162                                     
REMARK   3      L13:   2.4774 L23:   1.4828                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1672 S12:  -0.6907 S13:   0.5503                       
REMARK   3      S21:   2.4354 S22:   0.8375 S23:  -1.3699                       
REMARK   3      S31:  -0.4996 S32:   1.1037 S33:  -0.2306                       
REMARK   3   TLS GROUP : 107                                                    
REMARK   3    SELECTION: CHAIN 'N' AND (RESID 26 THROUGH 38 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 260.6817-398.8858 234.0055              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8894 T22:   0.5046                                     
REMARK   3      T33:   0.5428 T12:   0.1549                                     
REMARK   3      T13:   0.0853 T23:  -0.1773                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.7617 L22:   4.6350                                     
REMARK   3      L33:   2.6095 L12:   0.6228                                     
REMARK   3      L13:  -1.3211 L23:   0.6192                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4559 S12:  -0.5169 S13:   0.5660                       
REMARK   3      S21:   0.4835 S22:   0.2058 S23:   0.1836                       
REMARK   3      S31:   0.1660 S32:   0.0223 S33:   0.2336                       
REMARK   3   TLS GROUP : 108                                                    
REMARK   3    SELECTION: CHAIN 'N' AND (RESID 39 THROUGH 48 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 274.6859-397.3794 227.6356              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6707 T22:   0.7626                                     
REMARK   3      T33:   0.6438 T12:  -0.0185                                     
REMARK   3      T13:  -0.1011 T23:  -0.1124                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.5310 L22:   7.5540                                     
REMARK   3      L33:   2.0410 L12:   2.8910                                     
REMARK   3      L13:  -1.2200 L23:   2.9211                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.8681 S12:  -1.0448 S13:   0.5111                       
REMARK   3      S21:   0.1011 S22:   0.4302 S23:  -1.2724                       
REMARK   3      S31:  -0.4826 S32:   1.7249 S33:   0.4793                       
REMARK   3   TLS GROUP : 109                                                    
REMARK   3    SELECTION: CHAIN 'N' AND (RESID 49 THROUGH 61 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 271.9011-405.0710 237.1545              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3505 T22:   0.8082                                     
REMARK   3      T33:   0.8082 T12:   0.2033                                     
REMARK   3      T13:  -0.3335 T23:  -0.2574                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.2184 L22:   7.1371                                     
REMARK   3      L33:   6.7459 L12:  -1.6869                                     
REMARK   3      L13:   1.8581 L23:   1.2404                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3964 S12:  -0.4118 S13:   0.1297                       
REMARK   3      S21:   2.5351 S22:   1.2460 S23:  -1.4541                       
REMARK   3      S31:   0.7177 S32:   1.6662 S33:  -0.8792                       
REMARK   3   TLS GROUP : 110                                                    
REMARK   3    SELECTION: CHAIN 'N' AND (RESID 62 THROUGH 75 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 265.4765-397.3554 241.4290              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4502 T22:   0.8837                                     
REMARK   3      T33:   0.7528 T12:   0.1895                                     
REMARK   3      T13:  -0.1748 T23:  -0.2831                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9002 L22:   8.8543                                     
REMARK   3      L33:   8.1048 L12:  -2.4878                                     
REMARK   3      L13:   3.1474 L23:   0.0189                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5859 S12:  -2.2733 S13:   1.0081                       
REMARK   3      S21:   2.3412 S22:   1.3690 S23:  -0.7251                       
REMARK   3      S31:   0.1801 S32:   0.8759 S33:  -0.4646                       
REMARK   3   TLS GROUP : 111                                                    
REMARK   3    SELECTION: CHAIN 'N' AND (RESID 76 THROUGH 90 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 274.5107-393.4530 234.4395              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8968 T22:   0.7351                                     
REMARK   3      T33:   0.7622 T12:   0.0945                                     
REMARK   3      T13:  -0.2468 T23:  -0.2096                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.5853 L22:   8.0101                                     
REMARK   3      L33:   7.9462 L12:   5.1610                                     
REMARK   3      L13:   1.1990 L23:  -0.0215                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.4078 S12:  -0.4398 S13:   0.5028                       
REMARK   3      S21:   0.5050 S22:   0.4506 S23:  -0.7987                       
REMARK   3      S31:  -0.9878 S32:   1.2014 S33:   0.7783                       
REMARK   3   TLS GROUP : 112                                                    
REMARK   3    SELECTION: CHAIN 'N' AND (RESID 91 THROUGH 103 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 257.4662-396.7138 227.9879              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7023 T22:   0.4972                                     
REMARK   3      T33:   0.4627 T12:   0.1896                                     
REMARK   3      T13:  -0.0084 T23:  -0.0734                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.1078 L22:   8.2525                                     
REMARK   3      L33:   7.6577 L12:   6.8966                                     
REMARK   3      L13:  -2.0685 L23:  -1.8386                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4631 S12:  -0.2667 S13:   1.0209                       
REMARK   3      S21:   0.3002 S22:   0.5625 S23:   0.5816                       
REMARK   3      S31:  -0.9096 S32:  -0.4894 S33:  -0.1888                       
REMARK   3   TLS GROUP : 113                                                    
REMARK   3    SELECTION: CHAIN 'N' AND (RESID 104 THROUGH 108 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 278.3345-383.6584 235.3650              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.9342 T22:   0.7522                                     
REMARK   3      T33:   1.3926 T12:  -0.2486                                     
REMARK   3      T13:  -0.7374 T23:  -1.2678                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8734 L22:   5.3514                                     
REMARK   3      L33:   6.1169 L12:   3.1670                                     
REMARK   3      L13:   3.3917 L23:   5.7243                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3374 S12:   1.3756 S13:  -1.2233                       
REMARK   3      S21:  -1.3544 S22:  -0.8362 S23:   0.7767                       
REMARK   3      S31:   1.6762 S32:  -0.6185 S33:  -1.9565                       
REMARK   3   TLS GROUP : 114                                                    
REMARK   3    SELECTION: CHAIN 'O' AND (RESID 1 THROUGH 25 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 258.4744-461.4459 254.8791              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4407 T22:   0.9797                                     
REMARK   3      T33:   0.8267 T12:   0.2919                                     
REMARK   3      T13:   0.1075 T23:   0.2799                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.6300 L22:   2.8661                                     
REMARK   3      L33:   5.4368 L12:  -0.1328                                     
REMARK   3      L13:  -1.2001 L23:   3.7336                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.8753 S12:  -0.6704 S13:  -0.9480                       
REMARK   3      S21:   1.3139 S22:   0.9350 S23:   0.7423                       
REMARK   3      S31:   2.2135 S32:  -0.1250 S33:  -0.1395                       
REMARK   3   TLS GROUP : 115                                                    
REMARK   3    SELECTION: CHAIN 'O' AND (RESID 26 THROUGH 48 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 262.2054-450.9263 250.3891              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9971 T22:   0.9270                                     
REMARK   3      T33:   0.4179 T12:   0.3564                                     
REMARK   3      T13:   0.0769 T23:   0.1301                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0332 L22:   8.3366                                     
REMARK   3      L33:   4.0615 L12:  -1.4214                                     
REMARK   3      L13:   2.0638 L23:  -5.0434                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1780 S12:  -0.1432 S13:   0.1708                       
REMARK   3      S21:  -0.1656 S22:  -0.0380 S23:  -0.3952                       
REMARK   3      S31:   0.9121 S32:   0.4060 S33:   0.0752                       
REMARK   3   TLS GROUP : 116                                                    
REMARK   3    SELECTION: CHAIN 'O' AND (RESID 49 THROUGH 67 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 262.4174-455.1121 241.5970              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3803 T22:   0.9133                                     
REMARK   3      T33:   0.6570 T12:   0.4012                                     
REMARK   3      T13:  -0.1445 T23:  -0.0045                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.3567 L22:   3.2873                                     
REMARK   3      L33:   8.2131 L12:  -1.7228                                     
REMARK   3      L13:  -6.1119 L23:   4.2724                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1408 S12:   0.3592 S13:  -0.6389                       
REMARK   3      S21:  -0.0968 S22:   0.1328 S23:   0.0692                       
REMARK   3      S31:   0.9883 S32:   0.5754 S33:  -0.1046                       
REMARK   3   TLS GROUP : 117                                                    
REMARK   3    SELECTION: CHAIN 'O' AND (RESID 68 THROUGH 83 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 263.2535-462.0010 248.1762              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.4134 T22:   1.1007                                     
REMARK   3      T33:   0.8722 T12:   0.4549                                     
REMARK   3      T13:   0.1125 T23:   0.1200                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7740 L22:   2.5603                                     
REMARK   3      L33:   2.8386 L12:   1.3461                                     
REMARK   3      L13:  -0.2706 L23:  -1.2400                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.5923 S12:   0.3773 S13:   0.2300                       
REMARK   3      S21:   0.5365 S22:   1.2184 S23:  -0.4092                       
REMARK   3      S31:   1.4308 S32:   0.8545 S33:   0.2150                       
REMARK   3   TLS GROUP : 118                                                    
REMARK   3    SELECTION: CHAIN 'O' AND (RESID 84 THROUGH 103 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): 258.8389-448.0138 255.1572              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1125 T22:   0.9111                                     
REMARK   3      T33:   0.4648 T12:   0.4810                                     
REMARK   3      T13:   0.1057 T23:   0.1535                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.2112 L22:   6.8499                                     
REMARK   3      L33:   4.9432 L12:  -0.8097                                     
REMARK   3      L13:   4.2148 L23:  -4.2791                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2531 S12:  -0.6244 S13:  -0.2361                       
REMARK   3      S21:   0.0545 S22:   0.4937 S23:   0.1075                       
REMARK   3      S31:   0.8242 S32:  -0.0356 S33:  -0.1416                       
REMARK   3   TLS GROUP : 119                                                    
REMARK   3    SELECTION: CHAIN 'O' AND (RESID 104 THROUGH 108 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 269.3257-467.0269 258.1026              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.9848 T22:   1.1792                                     
REMARK   3      T33:   0.9576 T12:   0.2656                                     
REMARK   3      T13:  -0.3315 T23:   0.1568                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.7012 L22:   6.7565                                     
REMARK   3      L33:   0.9208 L12:  -0.7599                                     
REMARK   3      L13:  -0.4999 L23:   2.4732                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   2.7626 S12:   1.0395 S13:  -1.0129                       
REMARK   3      S21:  -1.1082 S22:  -2.5459 S23:  -0.6736                       
REMARK   3      S31:  -2.5134 S32:   0.1300 S33:   0.3798                       
REMARK   3   TLS GROUP : 120                                                    
REMARK   3    SELECTION: CHAIN 'P' AND (RESID 1 THROUGH 17 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 257.5271-461.8650 204.9319              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1056 T22:   0.4041                                     
REMARK   3      T33:   0.6662 T12:   0.0341                                     
REMARK   3      T13:   0.2382 T23:   0.0920                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.8239 L22:   4.1409                                     
REMARK   3      L33:   5.3785 L12:  -0.1379                                     
REMARK   3      L13:   2.8323 L23:   3.9458                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.7830 S12:  -0.4232 S13:  -1.3655                       
REMARK   3      S21:  -1.2783 S22:   0.5853 S23:  -0.6461                       
REMARK   3      S31:   0.4105 S32:   0.0243 S33:  -0.1535                       
REMARK   3   TLS GROUP : 121                                                    
REMARK   3    SELECTION: CHAIN 'P' AND (RESID 18 THROUGH 39 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 257.4487-452.0339 210.4331              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8326 T22:   0.3554                                     
REMARK   3      T33:   0.3910 T12:   0.0004                                     
REMARK   3      T13:   0.1415 T23:   0.0292                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.2180 L22:   4.2451                                     
REMARK   3      L33:   3.5216 L12:   3.9690                                     
REMARK   3      L13:   2.3504 L23:   2.3765                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1833 S12:  -0.0506 S13:  -0.4707                       
REMARK   3      S21:  -0.0630 S22:   0.2294 S23:  -0.2723                       
REMARK   3      S31:   0.1909 S32:   0.1626 S33:  -0.1003                       
REMARK   3   TLS GROUP : 122                                                    
REMARK   3    SELECTION: CHAIN 'P' AND (RESID 40 THROUGH 51 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 248.0907-451.8976 202.1886              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8517 T22:   0.2846                                     
REMARK   3      T33:   0.4617 T12:  -0.0880                                     
REMARK   3      T13:   0.0768 T23:   0.0434                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.0554 L22:   4.5363                                     
REMARK   3      L33:   3.8900 L12:  -2.1128                                     
REMARK   3      L13:  -1.9389 L23:   1.3056                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0652 S12:   0.5535 S13:   0.5679                       
REMARK   3      S21:   0.3744 S22:  -0.4491 S23:   0.9406                       
REMARK   3      S31:   2.5977 S32:  -1.1590 S33:   0.6916                       
REMARK   3   TLS GROUP : 123                                                    
REMARK   3    SELECTION: CHAIN 'P' AND (RESID 52 THROUGH 60 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 248.1750-449.1207 218.1549              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2588 T22:   0.5101                                     
REMARK   3      T33:   0.5973 T12:  -0.0272                                     
REMARK   3      T13:   0.1954 T23:   0.1171                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.7260 L22:   5.6090                                     
REMARK   3      L33:   5.4601 L12:   6.6078                                     
REMARK   3      L13:   6.6516 L23:   3.5647                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.5532 S12:  -0.3103 S13:   0.7431                       
REMARK   3      S21:   1.5793 S22:  -1.1743 S23:   0.4906                       
REMARK   3      S31:   1.7241 S32:  -0.0092 S33:   0.2897                       
REMARK   3   TLS GROUP : 124                                                    
REMARK   3    SELECTION: CHAIN 'P' AND (RESID 61 THROUGH 83 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 251.2395-457.4978 213.0760              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8490 T22:   0.4434                                     
REMARK   3      T33:   0.4555 T12:   0.0114                                     
REMARK   3      T13:   0.1200 T23:   0.0599                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.2038 L22:   6.9889                                     
REMARK   3      L33:   3.7888 L12:   3.7140                                     
REMARK   3      L13:   3.6901 L23:   3.9427                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4368 S12:  -0.3923 S13:  -0.6802                       
REMARK   3      S21:  -0.1365 S22:   0.3276 S23:  -0.2283                       
REMARK   3      S31:   0.3761 S32:  -0.2757 S33:   0.0953                       
REMARK   3   TLS GROUP : 125                                                    
REMARK   3    SELECTION: CHAIN 'P' AND (RESID 84 THROUGH 99 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 250.0514-457.7735 203.1654              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8314 T22:   0.4207                                     
REMARK   3      T33:   0.5102 T12:   0.0327                                     
REMARK   3      T13:  -0.0687 T23:   0.0845                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.0206 L22:   7.8909                                     
REMARK   3      L33:   5.8536 L12:   5.4627                                     
REMARK   3      L13:  -0.7080 L23:   2.8007                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.7046 S12:  -0.0824 S13:  -0.5857                       
REMARK   3      S21:  -1.1724 S22:   0.0546 S23:  -0.0457                       
REMARK   3      S31:   0.6233 S32:  -0.4822 S33:   0.7107                       
REMARK   3   TLS GROUP : 126                                                    
REMARK   3    SELECTION: CHAIN 'P' AND (RESID 100 THROUGH 119 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 252.0524-441.0255 209.4831              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6168 T22:   0.3171                                     
REMARK   3      T33:   0.3923 T12:  -0.0194                                     
REMARK   3      T13:   0.1017 T23:  -0.0017                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.2870 L22:   7.0747                                     
REMARK   3      L33:   8.9357 L12:  -6.1597                                     
REMARK   3      L13:  -4.7579 L23:   5.0693                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0335 S12:  -0.4140 S13:  -0.3276                       
REMARK   3      S21:  -0.0829 S22:   0.1566 S23:  -0.1475                       
REMARK   3      S31:  -0.2036 S32:   0.2397 S33:  -0.0006                       
REMARK   3   TLS GROUP : 127                                                    
REMARK   3    SELECTION: CHAIN 'P' AND (RESID 120 THROUGH 126 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 252.0586-465.9538 197.8455              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3783 T22:  -0.1099                                     
REMARK   3      T33:   0.7354 T12:  -0.2148                                     
REMARK   3      T13:   0.3131 T23:  -0.0688                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.8111 L22:   5.2487                                     
REMARK   3      L33:   1.6641 L12:   2.0689                                     
REMARK   3      L13:  -0.0278 L23:   1.8544                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2676 S12:   0.0869 S13:  -1.1288                       
REMARK   3      S21:   0.2727 S22:  -0.1783 S23:   0.4843                       
REMARK   3      S31:   0.1097 S32:  -0.1519 S33:  -0.9629                       
REMARK   3   TLS GROUP : 128                                                    
REMARK   3    SELECTION: CHAIN 'Q' AND (RESID 1 THROUGH 39 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 267.7903-401.7313 211.8625              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6149 T22:   0.3595                                     
REMARK   3      T33:   0.4783 T12:   0.0371                                     
REMARK   3      T13:   0.0233 T23:  -0.0717                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.4485 L22:   3.5557                                     
REMARK   3      L33:   3.1605 L12:   0.6333                                     
REMARK   3      L13:  -0.9154 L23:   0.0731                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1315 S12:   0.0363 S13:   0.1714                       
REMARK   3      S21:  -0.9178 S22:  -0.0444 S23:  -0.6133                       
REMARK   3      S31:  -0.2811 S32:   0.3053 S33:  -0.0619                       
REMARK   3   TLS GROUP : 129                                                    
REMARK   3    SELECTION: CHAIN 'Q' AND (RESID 40 THROUGH 51 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 262.2526-394.5192 219.6181              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7592 T22:   0.5105                                     
REMARK   3      T33:   0.6455 T12:   0.0404                                     
REMARK   3      T13:   0.0312 T23:  -0.1167                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.3523 L22:   6.4419                                     
REMARK   3      L33:   8.1439 L12:   4.8830                                     
REMARK   3      L13:  -1.0504 L23:  -2.4408                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3063 S12:  -0.6962 S13:   0.9742                       
REMARK   3      S21:   2.0087 S22:  -0.0860 S23:   0.5868                       
REMARK   3      S31:  -0.1209 S32:   0.7794 S33:  -0.1078                       
REMARK   3   TLS GROUP : 130                                                    
REMARK   3    SELECTION: CHAIN 'Q' AND (RESID 52 THROUGH 60 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 255.0293-408.4379 216.3026              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5808 T22:   0.5030                                     
REMARK   3      T33:   0.3983 T12:   0.1117                                     
REMARK   3      T13:  -0.1239 T23:   0.0725                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.6285 L22:   9.3043                                     
REMARK   3      L33:   5.6380 L12:  -3.9517                                     
REMARK   3      L13:  -2.5504 L23:  -2.3452                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.7490 S12:  -0.1653 S13:   0.7202                       
REMARK   3      S21:   0.3841 S22:   0.1460 S23:  -0.3640                       
REMARK   3      S31:  -0.1850 S32:  -1.0858 S33:   0.2438                       
REMARK   3   TLS GROUP : 131                                                    
REMARK   3    SELECTION: CHAIN 'Q' AND (RESID 61 THROUGH 83 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 260.0991-402.2488 209.9860              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7156 T22:   0.3303                                     
REMARK   3      T33:   0.4326 T12:  -0.0588                                     
REMARK   3      T13:   0.0738 T23:  -0.0338                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.2178 L22:   2.3396                                     
REMARK   3      L33:   6.0829 L12:  -1.0773                                     
REMARK   3      L13:   1.5596 L23:  -2.4172                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1672 S12:   0.2120 S13:   0.0658                       
REMARK   3      S21:  -0.5964 S22:   0.0998 S23:  -0.0294                       
REMARK   3      S31:  -0.1823 S32:   0.1754 S33:  -0.2136                       
REMARK   3   TLS GROUP : 132                                                    
REMARK   3    SELECTION: CHAIN 'Q' AND (RESID 84 THROUGH 99 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 263.5431-393.6509 213.3815              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9240 T22:   0.3954                                     
REMARK   3      T33:   0.5543 T12:  -0.0056                                     
REMARK   3      T13:   0.0824 T23:  -0.0549                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.4276 L22:   4.6989                                     
REMARK   3      L33:   9.1094 L12:  -3.6926                                     
REMARK   3      L13:   3.4674 L23:  -6.2231                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0970 S12:  -0.1797 S13:   0.4385                       
REMARK   3      S21:   0.3577 S22:   0.5407 S23:   0.1876                       
REMARK   3      S31:  -0.8103 S32:   0.1740 S33:  -0.3860                       
REMARK   3   TLS GROUP : 133                                                    
REMARK   3    SELECTION: CHAIN 'Q' AND (RESID 100 THROUGH 119 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 262.2797-406.6634 226.0045              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6259 T22:   0.4851                                     
REMARK   3      T33:   0.4877 T12:   0.1995                                     
REMARK   3      T13:  -0.0174 T23:  -0.0841                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.4440 L22:   4.1171                                     
REMARK   3      L33:   6.5552 L12:   3.9219                                     
REMARK   3      L13:  -5.6749 L23:  -2.8791                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0858 S12:  -0.6245 S13:   0.2781                       
REMARK   3      S21:   0.1398 S22:   0.0529 S23:  -0.2340                       
REMARK   3      S31:   0.0425 S32:   0.5039 S33:  -0.1701                       
REMARK   3   TLS GROUP : 134                                                    
REMARK   3    SELECTION: CHAIN 'Q' AND (RESID 120 THROUGH 126 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 267.8905-387.0533 207.6852              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2783 T22:   0.3826                                     
REMARK   3      T33:   0.7003 T12:  -0.1500                                     
REMARK   3      T13:   0.1274 T23:  -0.1379                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.9863 L22:   9.6735                                     
REMARK   3      L33:   2.1215 L12:  -2.2022                                     
REMARK   3      L13:   2.2422 L23:  -0.6068                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1094 S12:  -0.0146 S13:   0.5557                       
REMARK   3      S21:   0.2525 S22:  -0.0179 S23:   0.4242                       
REMARK   3      S31:  -1.5824 S32:   0.6220 S33:   0.2841                       
REMARK   3   TLS GROUP : 135                                                    
REMARK   3    SELECTION: CHAIN 'R' AND (RESID 1 THROUGH 17 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): 277.5991-435.9762 261.6018              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0412 T22:   1.2401                                     
REMARK   3      T33:   1.0276 T12:   0.2737                                     
REMARK   3      T13:  -0.1178 T23:   0.1339                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.8117 L22:   5.7623                                     
REMARK   3      L33:   7.1203 L12:   3.0903                                     
REMARK   3      L13:   3.2955 L23:   5.9976                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5391 S12:  -0.0813 S13:   0.3346                       
REMARK   3      S21:   1.3322 S22:  -0.3826 S23:  -0.4589                       
REMARK   3      S31:   1.4686 S32:   1.5758 S33:   0.6468                       
REMARK   3   TLS GROUP : 136                                                    
REMARK   3    SELECTION: CHAIN 'R' AND (RESID 18 THROUGH 39 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 271.7227-435.2863 252.0792              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9546 T22:   0.9497                                     
REMARK   3      T33:   0.8669 T12:   0.3516                                     
REMARK   3      T13:  -0.1089 T23:   0.2015                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.6534 L22:   0.1237                                     
REMARK   3      L33:   4.1415 L12:   0.4412                                     
REMARK   3      L13:   1.3347 L23:  -0.6556                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0077 S12:   0.6257 S13:   0.8492                       
REMARK   3      S21:   0.4545 S22:  -0.2354 S23:  -0.6343                       
REMARK   3      S31:   0.0225 S32:   1.1082 S33:   0.3068                       
REMARK   3   TLS GROUP : 137                                                    
REMARK   3    SELECTION: CHAIN 'R' AND (RESID 40 THROUGH 60 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 263.1995-436.5436 256.2513              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7378 T22:   0.8038                                     
REMARK   3      T33:   0.6157 T12:   0.3540                                     
REMARK   3      T13:  -0.0673 T23:  -0.0327                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.3016 L22:   3.4714                                     
REMARK   3      L33:   4.3906 L12:   1.9924                                     
REMARK   3      L13:  -1.8828 L23:   2.4966                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5098 S12:  -0.1657 S13:   0.5265                       
REMARK   3      S21:   1.1027 S22:  -0.2734 S23:  -0.2554                       
REMARK   3      S31:  -0.3773 S32:  -0.0501 S33:   0.7576                       
REMARK   3   TLS GROUP : 138                                                    
REMARK   3    SELECTION: CHAIN 'R' AND (RESID 61 THROUGH 99 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): 268.9452-433.9028 260.3070              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0733 T22:   0.7569                                     
REMARK   3      T33:   0.7482 T12:   0.2550                                     
REMARK   3      T13:  -0.2085 T23:  -0.0392                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.9535 L22:   6.2312                                     
REMARK   3      L33:   4.6231 L12:  -0.1578                                     
REMARK   3      L13:   3.0453 L23:  -0.2389                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6513 S12:  -0.8799 S13:   0.6705                       
REMARK   3      S21:   1.5341 S22:   0.1592 S23:  -0.3549                       
REMARK   3      S31:  -0.2084 S32:   0.5294 S33:   0.4423                       
REMARK   3   TLS GROUP : 139                                                    
REMARK   3    SELECTION: CHAIN 'R' AND (RESID 100 THROUGH 119 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 261.9535-440.6709 246.8421              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7012 T22:   0.7631                                     
REMARK   3      T33:   0.5136 T12:   0.2076                                     
REMARK   3      T13:   0.1071 T23:   0.1408                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.3892 L22:   4.4829                                     
REMARK   3      L33:   5.5102 L12:  -1.6445                                     
REMARK   3      L13:   4.4623 L23:  -0.7588                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0774 S12:   0.2983 S13:   0.2426                       
REMARK   3      S21:   0.5642 S22:  -0.1000 S23:  -0.3474                       
REMARK   3      S31:   0.0457 S32:   0.6822 S33:  -0.0532                       
REMARK   3   TLS GROUP : 140                                                    
REMARK   3    SELECTION: CHAIN 'R' AND (RESID 120 THROUGH 126 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): 276.0140-440.6632 270.3653              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.8753 T22:   1.2668                                     
REMARK   3      T33:   0.9441 T12:   0.5519                                     
REMARK   3      T13:  -0.4395 T23:  -0.1375                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.6938 L22:   1.7556                                     
REMARK   3      L33:   1.1920 L12:  -0.1876                                     
REMARK   3      L13:   0.7325 L23:   1.3401                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3086 S12:  -0.2759 S13:   0.1323                       
REMARK   3      S21:   1.1783 S22:   0.1616 S23:   0.6075                       
REMARK   3      S31:  -0.1220 S32:   1.5617 S33:  -0.2260                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : 3                                           
REMARK   3   NCS GROUP : 1                                                      
REMARK   3    NCS OPERATOR : 1                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN G AND (RESSEQ 1:12 OR RESSEQ 14:39   
REMARK   3                          OR (RESID 40 AND (NAME O OR NAME N OR       
REMARK   3                          NAME CA )) OR (RESID 41 AND (NAME O OR      
REMARK   3                          NAME N OR NAME C OR NAME CB OR NAME CG ))   
REMARK   3                          OR RESSEQ 42:44 OR (RESID 45 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME CB OR NAME CG OR NAME    
REMARK   3                          CD2 OR NAME C OR NAME O )) OR RESSEQ 46:    
REMARK   3                          52 OR (RESID 53 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD1 OR NAME CE1 OR NAME CZ OR NAME     
REMARK   3                          OH )) OR (RESID 54 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME OD2)) OR RESSEQ 55:59 OR (RESID     
REMARK   3                          60 AND (NAME N OR NAME CA OR NAME C OR      
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD1    
REMARK   3                          OR NAME CE1 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          RESSEQ 61 OR (RESID 62 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD1)) OR RESSEQ 63:67 OR    
REMARK   3                          (RESID 68 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ )) OR RESSEQ     
REMARK   3                          69:80 OR (RESID 81 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1)) OR RESSEQ 82:86 OR RESSEQ     
REMARK   3                          88:94 OR (RESID 95 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME CB OR NAME CG OR NAME CZ OR NAME    
REMARK   3                          OH OR NAME C OR NAME O )) OR RESSEQ 96:     
REMARK   3                          107 OR (RESID 108 AND (NAME O OR NAME N     
REMARK   3                          OR NAME CA OR NAME C OR NAME CB OR NAME     
REMARK   3                          CG OR NAME CD2 OR NAME CE2 OR NAME CZ OR    
REMARK   3                          NAME OH )) OR (RESID 109 AND (NAME O OR     
REMARK   3                          NAME N OR NAME CA OR NAME C OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD1 OR NAME CE1 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR (RESID 110 AND (NAME    
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1 OR NAME CE1 OR    
REMARK   3                          NAME CZ OR NAME OH )) OR (RESID 111 AND     
REMARK   3                          (NAME O OR NAME N OR NAME CA OR NAME C OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD2 OR NAME      
REMARK   3                          CE2 OR NAME CZ OR NAME OH )) OR RESSEQ      
REMARK   3                          112:124))                                   
REMARK   3     SELECTION          : (CHAIN H AND (RESSEQ 1:12 OR RESSEQ 14:39   
REMARK   3                          OR (RESID 40 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C )) OR (RESID 41 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD )  
REMARK   3                          ) OR RESSEQ 42:44 OR (RESID 45 AND (NAME    
REMARK   3                          N OR NAME CA OR NAME CB OR NAME CG OR       
REMARK   3                          NAME CD2 OR NAME C OR NAME O )) OR RESSEQ   
REMARK   3                          46:52 OR (RESID 53 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1 OR NAME CE1 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR (RESID 54 AND (NAME N OR      
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD2)) OR RESSEQ 55:59 OR    
REMARK   3                          (RESID 60 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 61 OR (RESID 62 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD1)) OR RESSEQ 63:67 OR    
REMARK   3                          (RESID 68 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ )) OR RESSEQ     
REMARK   3                          69:80 OR (RESID 81 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1)) OR RESSEQ 82:86 OR RESSEQ     
REMARK   3                          88:94 OR (RESID 95 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME CB OR NAME CG OR NAME CZ OR NAME    
REMARK   3                          OH OR NAME C OR NAME O )) OR RESSEQ 96:     
REMARK   3                          107 OR (RESID 108 AND (NAME O OR NAME N     
REMARK   3                          OR NAME CA OR NAME C OR NAME CB OR NAME     
REMARK   3                          CG OR NAME CD2 OR NAME CE2 OR NAME CZ OR    
REMARK   3                          NAME OH )) OR (RESID 109 AND (NAME O OR     
REMARK   3                          NAME N OR NAME CA OR NAME C OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD1 OR NAME CE1 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR (RESID 110 AND (NAME    
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1 OR NAME CE1 OR    
REMARK   3                          NAME CZ OR NAME OH )) OR (RESID 111 AND     
REMARK   3                          (NAME O OR NAME N OR NAME CA OR NAME C OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD2 OR NAME      
REMARK   3                          CE2 OR NAME CZ OR NAME OH )) OR RESSEQ      
REMARK   3                          112:124))                                   
REMARK   3     ATOM PAIRS NUMBER  : 3306                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 2                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN G AND (RESSEQ 1:12 OR RESSEQ 14:39   
REMARK   3                          OR (RESID 40 AND (NAME O OR NAME N OR       
REMARK   3                          NAME CA )) OR (RESID 41 AND (NAME O OR      
REMARK   3                          NAME N OR NAME C OR NAME CB OR NAME CG ))   
REMARK   3                          OR RESSEQ 42:44 OR (RESID 45 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME CB OR NAME CG OR NAME    
REMARK   3                          CD2 OR NAME C OR NAME O )) OR RESSEQ 46:    
REMARK   3                          52 OR (RESID 53 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD1 OR NAME CE1 OR NAME CZ OR NAME     
REMARK   3                          OH )) OR (RESID 54 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME OD2)) OR RESSEQ 55:59 OR (RESID     
REMARK   3                          60 AND (NAME N OR NAME CA OR NAME C OR      
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD1    
REMARK   3                          OR NAME CE1 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          RESSEQ 61 OR (RESID 62 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD1)) OR RESSEQ 63:67 OR    
REMARK   3                          (RESID 68 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ )) OR RESSEQ     
REMARK   3                          69:80 OR (RESID 81 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1)) OR RESSEQ 82:86 OR RESSEQ     
REMARK   3                          88:94 OR (RESID 95 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME CB OR NAME CG OR NAME CZ OR NAME    
REMARK   3                          OH OR NAME C OR NAME O )) OR RESSEQ 96:     
REMARK   3                          107 OR (RESID 108 AND (NAME O OR NAME N     
REMARK   3                          OR NAME CA OR NAME C OR NAME CB OR NAME     
REMARK   3                          CG OR NAME CD2 OR NAME CE2 OR NAME CZ OR    
REMARK   3                          NAME OH )) OR (RESID 109 AND (NAME O OR     
REMARK   3                          NAME N OR NAME CA OR NAME C OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD1 OR NAME CE1 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR (RESID 110 AND (NAME    
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1 OR NAME CE1 OR    
REMARK   3                          NAME CZ OR NAME OH )) OR (RESID 111 AND     
REMARK   3                          (NAME O OR NAME N OR NAME CA OR NAME C OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD2 OR NAME      
REMARK   3                          CE2 OR NAME CZ OR NAME OH )) OR RESSEQ      
REMARK   3                          112:124))                                   
REMARK   3     SELECTION          : (CHAIN I AND (RESSEQ 1:12 OR RESSEQ 14:39   
REMARK   3                          OR (RESID 40 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C )) OR (RESID 41 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD )  
REMARK   3                          ) OR RESSEQ 42:44 OR (RESID 45 AND (NAME    
REMARK   3                          N OR NAME CA OR NAME CB OR NAME CG OR       
REMARK   3                          NAME CD2 OR NAME C OR NAME O )) OR RESSEQ   
REMARK   3                          46:52 OR (RESID 53 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1 OR NAME CE1 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR (RESID 54 AND (NAME N OR      
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD2)) OR RESSEQ 55:59 OR    
REMARK   3                          (RESID 60 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 61 OR (RESID 62 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD1)) OR RESSEQ 63:67 OR    
REMARK   3                          (RESID 68 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ )) OR RESSEQ     
REMARK   3                          69:80 OR (RESID 81 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1)) OR RESSEQ 82:86 OR RESSEQ     
REMARK   3                          88:94 OR (RESID 95 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME CB OR NAME CG OR NAME CZ OR NAME    
REMARK   3                          OH OR NAME C OR NAME O )) OR RESSEQ 96:     
REMARK   3                          107 OR (RESID 108 AND (NAME O OR NAME N     
REMARK   3                          OR NAME CA OR NAME C OR NAME CB OR NAME     
REMARK   3                          CG OR NAME CD2 OR NAME CE2 OR NAME CZ OR    
REMARK   3                          NAME OH )) OR (RESID 109 AND (NAME O OR     
REMARK   3                          NAME N OR NAME CA OR NAME C OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD1 OR NAME CE1 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR (RESID 110 AND (NAME    
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1 OR NAME CE1 OR    
REMARK   3                          NAME CZ OR NAME OH )) OR (RESID 111 AND     
REMARK   3                          (NAME O OR NAME N OR NAME CA OR NAME C OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD2 OR NAME      
REMARK   3                          CE2 OR NAME CZ OR NAME OH )) OR RESSEQ      
REMARK   3                          112:124))                                   
REMARK   3     ATOM PAIRS NUMBER  : 3306                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 3                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN G AND (RESSEQ 1:12 OR RESSEQ 14:39   
REMARK   3                          OR (RESID 40 AND (NAME O OR NAME N OR       
REMARK   3                          NAME CA )) OR (RESID 41 AND (NAME O OR      
REMARK   3                          NAME N OR NAME C OR NAME CB OR NAME CG ))   
REMARK   3                          OR RESSEQ 42:44 OR (RESID 45 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME CB OR NAME CG OR NAME    
REMARK   3                          CD2 OR NAME C OR NAME O )) OR RESSEQ 46:    
REMARK   3                          52 OR (RESID 53 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD1 OR NAME CE1 OR NAME CZ OR NAME     
REMARK   3                          OH )) OR (RESID 54 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME OD2)) OR RESSEQ 55:59 OR (RESID     
REMARK   3                          60 AND (NAME N OR NAME CA OR NAME C OR      
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD1    
REMARK   3                          OR NAME CE1 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          RESSEQ 61 OR (RESID 62 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD1)) OR RESSEQ 63:67 OR    
REMARK   3                          (RESID 68 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ )) OR RESSEQ     
REMARK   3                          69:80 OR (RESID 81 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1)) OR RESSEQ 82:86 OR RESSEQ     
REMARK   3                          88:94 OR (RESID 95 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME CB OR NAME CG OR NAME CZ OR NAME    
REMARK   3                          OH OR NAME C OR NAME O )) OR RESSEQ 96:     
REMARK   3                          107 OR (RESID 108 AND (NAME O OR NAME N     
REMARK   3                          OR NAME CA OR NAME C OR NAME CB OR NAME     
REMARK   3                          CG OR NAME CD2 OR NAME CE2 OR NAME CZ OR    
REMARK   3                          NAME OH )) OR (RESID 109 AND (NAME O OR     
REMARK   3                          NAME N OR NAME CA OR NAME C OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD1 OR NAME CE1 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR (RESID 110 AND (NAME    
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1 OR NAME CE1 OR    
REMARK   3                          NAME CZ OR NAME OH )) OR (RESID 111 AND     
REMARK   3                          (NAME O OR NAME N OR NAME CA OR NAME C OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD2 OR NAME      
REMARK   3                          CE2 OR NAME CZ OR NAME OH )) OR RESSEQ      
REMARK   3                          112:124))                                   
REMARK   3     SELECTION          : (CHAIN P AND (RESSEQ 1:12 OR RESSEQ 14:39   
REMARK   3                          OR (RESID 40 AND (NAME O OR NAME N OR       
REMARK   3                          NAME CA )) OR (RESID 41 AND (NAME O OR      
REMARK   3                          NAME N OR NAME C OR NAME CB OR NAME CG ))   
REMARK   3                          OR RESSEQ 42:44 OR (RESID 45 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME CB OR NAME CG OR NAME    
REMARK   3                          CD2 OR NAME C OR NAME O )) OR RESSEQ 46:    
REMARK   3                          52 OR (RESID 53 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD1 OR NAME CE1 OR NAME CZ OR NAME     
REMARK   3                          OH )) OR (RESID 54 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME OD2)) OR RESSEQ 55:59 OR (RESID     
REMARK   3                          60 AND (NAME N OR NAME CA OR NAME C OR      
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD1    
REMARK   3                          OR NAME CE1 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          RESSEQ 61 OR (RESID 62 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD1)) OR RESSEQ 63:67 OR    
REMARK   3                          (RESID 68 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ )) OR RESSEQ     
REMARK   3                          69:80 OR (RESID 81 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1)) OR RESSEQ 82:86 OR RESSEQ     
REMARK   3                          88:94 OR (RESID 95 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME CB OR NAME CG OR NAME CZ OR NAME    
REMARK   3                          OH OR NAME C OR NAME O )) OR RESSEQ 96:     
REMARK   3                          107 OR (RESID 108 AND (NAME O OR NAME N     
REMARK   3                          OR NAME CA OR NAME C OR NAME CB OR NAME     
REMARK   3                          CG OR NAME CD2 OR NAME CE2 OR NAME CZ OR    
REMARK   3                          NAME OH )) OR (RESID 109 AND (NAME O OR     
REMARK   3                          NAME N OR NAME CA OR NAME C OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD1 OR NAME CE1 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR (RESID 110 AND (NAME    
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1 OR NAME CE1 OR    
REMARK   3                          NAME CZ OR NAME OH )) OR (RESID 111 AND     
REMARK   3                          (NAME O OR NAME N OR NAME CA OR NAME C OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD2 OR NAME      
REMARK   3                          CE2 OR NAME CZ OR NAME OH )) OR RESSEQ      
REMARK   3                          112:124))                                   
REMARK   3     ATOM PAIRS NUMBER  : 3306                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 4                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN G AND (RESSEQ 1:12 OR RESSEQ 14:39   
REMARK   3                          OR (RESID 40 AND (NAME O OR NAME N OR       
REMARK   3                          NAME CA )) OR (RESID 41 AND (NAME O OR      
REMARK   3                          NAME N OR NAME C OR NAME CB OR NAME CG ))   
REMARK   3                          OR RESSEQ 42:44 OR (RESID 45 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME CB OR NAME CG OR NAME    
REMARK   3                          CD2 OR NAME C OR NAME O )) OR RESSEQ 46:    
REMARK   3                          52 OR (RESID 53 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD1 OR NAME CE1 OR NAME CZ OR NAME     
REMARK   3                          OH )) OR (RESID 54 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME OD2)) OR RESSEQ 55:59 OR (RESID     
REMARK   3                          60 AND (NAME N OR NAME CA OR NAME C OR      
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD1    
REMARK   3                          OR NAME CE1 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          RESSEQ 61 OR (RESID 62 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD1)) OR RESSEQ 63:67 OR    
REMARK   3                          (RESID 68 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ )) OR RESSEQ     
REMARK   3                          69:80 OR (RESID 81 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1)) OR RESSEQ 82:86 OR RESSEQ     
REMARK   3                          88:94 OR (RESID 95 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME CB OR NAME CG OR NAME CZ OR NAME    
REMARK   3                          OH OR NAME C OR NAME O )) OR RESSEQ 96:     
REMARK   3                          107 OR (RESID 108 AND (NAME O OR NAME N     
REMARK   3                          OR NAME CA OR NAME C OR NAME CB OR NAME     
REMARK   3                          CG OR NAME CD2 OR NAME CE2 OR NAME CZ OR    
REMARK   3                          NAME OH )) OR (RESID 109 AND (NAME O OR     
REMARK   3                          NAME N OR NAME CA OR NAME C OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD1 OR NAME CE1 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR (RESID 110 AND (NAME    
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1 OR NAME CE1 OR    
REMARK   3                          NAME CZ OR NAME OH )) OR (RESID 111 AND     
REMARK   3                          (NAME O OR NAME N OR NAME CA OR NAME C OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD2 OR NAME      
REMARK   3                          CE2 OR NAME CZ OR NAME OH )) OR RESSEQ      
REMARK   3                          112:124))                                   
REMARK   3     SELECTION          : (CHAIN Q AND (RESSEQ 1:12 OR RESSEQ 14:39   
REMARK   3                          OR (RESID 40 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C )) OR (RESID 41 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD )  
REMARK   3                          ) OR RESSEQ 42:44 OR (RESID 45 AND (NAME    
REMARK   3                          N OR NAME CA OR NAME CB OR NAME CG OR       
REMARK   3                          NAME CD2 OR NAME C OR NAME O )) OR RESSEQ   
REMARK   3                          46:52 OR (RESID 53 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1 OR NAME CE1 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR (RESID 54 AND (NAME N OR      
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD2)) OR RESSEQ 55:59 OR    
REMARK   3                          (RESID 60 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 61 OR (RESID 62 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD1)) OR RESSEQ 63:67 OR    
REMARK   3                          (RESID 68 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ )) OR RESSEQ     
REMARK   3                          69:80 OR (RESID 81 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1)) OR RESSEQ 82:86 OR RESSEQ     
REMARK   3                          88:94 OR (RESID 95 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME CB OR NAME CG OR NAME CZ OR NAME    
REMARK   3                          OH OR NAME C OR NAME O )) OR RESSEQ 96:     
REMARK   3                          107 OR (RESID 108 AND (NAME O OR NAME N     
REMARK   3                          OR NAME CA OR NAME C OR NAME CB OR NAME     
REMARK   3                          CG OR NAME CD2 OR NAME CE2 OR NAME CZ OR    
REMARK   3                          NAME OH )) OR (RESID 109 AND (NAME O OR     
REMARK   3                          NAME N OR NAME CA OR NAME C OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD1 OR NAME CE1 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR (RESID 110 AND (NAME    
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1 OR NAME CE1 OR    
REMARK   3                          NAME CZ OR NAME OH )) OR (RESID 111 AND     
REMARK   3                          (NAME O OR NAME N OR NAME CA OR NAME C OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD2 OR NAME      
REMARK   3                          CE2 OR NAME CZ OR NAME OH )) OR RESSEQ      
REMARK   3                          112:124))                                   
REMARK   3     ATOM PAIRS NUMBER  : 3306                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 5                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN G AND (RESSEQ 1:12 OR RESSEQ 14:39   
REMARK   3                          OR (RESID 40 AND (NAME O OR NAME N OR       
REMARK   3                          NAME CA )) OR (RESID 41 AND (NAME O OR      
REMARK   3                          NAME N OR NAME C OR NAME CB OR NAME CG ))   
REMARK   3                          OR RESSEQ 42:44 OR (RESID 45 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME CB OR NAME CG OR NAME    
REMARK   3                          CD2 OR NAME C OR NAME O )) OR RESSEQ 46:    
REMARK   3                          52 OR (RESID 53 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD1 OR NAME CE1 OR NAME CZ OR NAME     
REMARK   3                          OH )) OR (RESID 54 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME OD2)) OR RESSEQ 55:59 OR (RESID     
REMARK   3                          60 AND (NAME N OR NAME CA OR NAME C OR      
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD1    
REMARK   3                          OR NAME CE1 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          RESSEQ 61 OR (RESID 62 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD1)) OR RESSEQ 63:67 OR    
REMARK   3                          (RESID 68 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ )) OR RESSEQ     
REMARK   3                          69:80 OR (RESID 81 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1)) OR RESSEQ 82:86 OR RESSEQ     
REMARK   3                          88:94 OR (RESID 95 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME CB OR NAME CG OR NAME CZ OR NAME    
REMARK   3                          OH OR NAME C OR NAME O )) OR RESSEQ 96:     
REMARK   3                          107 OR (RESID 108 AND (NAME O OR NAME N     
REMARK   3                          OR NAME CA OR NAME C OR NAME CB OR NAME     
REMARK   3                          CG OR NAME CD2 OR NAME CE2 OR NAME CZ OR    
REMARK   3                          NAME OH )) OR (RESID 109 AND (NAME O OR     
REMARK   3                          NAME N OR NAME CA OR NAME C OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD1 OR NAME CE1 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR (RESID 110 AND (NAME    
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1 OR NAME CE1 OR    
REMARK   3                          NAME CZ OR NAME OH )) OR (RESID 111 AND     
REMARK   3                          (NAME O OR NAME N OR NAME CA OR NAME C OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD2 OR NAME      
REMARK   3                          CE2 OR NAME CZ OR NAME OH )) OR RESSEQ      
REMARK   3                          112:124))                                   
REMARK   3     SELECTION          : (CHAIN R AND (RESSEQ 1:12 OR RESSEQ 14:39   
REMARK   3                          OR (RESID 40 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C )) OR (RESID 41 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD )  
REMARK   3                          ) OR RESSEQ 42:44 OR (RESID 45 AND (NAME    
REMARK   3                          N OR NAME CA OR NAME CB OR NAME CG OR       
REMARK   3                          NAME CD2 OR NAME C OR NAME O )) OR RESSEQ   
REMARK   3                          46:52 OR (RESID 53 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1 OR NAME CE1 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR (RESID 54 AND (NAME N OR      
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD2)) OR RESSEQ 55:59 OR    
REMARK   3                          (RESID 60 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 61 OR (RESID 62 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME OD1)) OR RESSEQ 63:67 OR    
REMARK   3                          (RESID 68 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1 OR NAME CE1 OR NAME CZ )) OR RESSEQ     
REMARK   3                          69:80 OR (RESID 81 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD1)) OR RESSEQ 82:86 OR RESSEQ     
REMARK   3                          88:94 OR (RESID 95 AND (NAME N OR NAME CA   
REMARK   3                          OR NAME CB OR NAME CG OR NAME CZ OR NAME    
REMARK   3                          OH OR NAME C OR NAME O )) OR RESSEQ 96:     
REMARK   3                          107 OR (RESID 108 AND (NAME O OR NAME N     
REMARK   3                          OR NAME CA OR NAME C OR NAME CB OR NAME     
REMARK   3                          CG OR NAME CD2 OR NAME CE2 OR NAME CZ OR    
REMARK   3                          NAME OH )) OR (RESID 109 AND (NAME O OR     
REMARK   3                          NAME N OR NAME CA OR NAME C OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD1 OR NAME CE1 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR (RESID 110 AND (NAME    
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1 OR NAME CE1 OR    
REMARK   3                          NAME CZ OR NAME OH )) OR (RESID 111 AND     
REMARK   3                          (NAME O OR NAME N OR NAME CA OR NAME C OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD2 OR NAME      
REMARK   3                          CE2 OR NAME CZ OR NAME OH )) OR RESSEQ      
REMARK   3                          112:124))                                   
REMARK   3     ATOM PAIRS NUMBER  : 3306                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3   NCS GROUP : 2                                                      
REMARK   3    NCS OPERATOR : 1                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN A AND (RESSEQ 11:24 OR (RESID 26     
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME CD1)) OR    
REMARK   3                          RESSEQ 27:28 OR (RESID 29 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2)) OR RESSEQ 33:35 OR    
REMARK   3                          (RESID 36 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1)) OR RESSEQ 37:44 OR (RESID 45 AND      
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME OD1)) OR         
REMARK   3                          RESSEQ 46:55 OR (RESID 56 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2 OR NAME CE2 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR RESSEQ 57:58 OR         
REMARK   3                          (RESID 59 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 60:62 OR (RESID 63 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR RESSEQ 64:74    
REMARK   3                          OR (RESID 75 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 76:85 OR RESSEQ 90:    
REMARK   3                          92 OR (RESID 93 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 94:102 OR RESSEQ 104:  
REMARK   3                          114 OR (RESID 115 AND (NAME N OR NAME CA    
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD2 OR NAME CE2 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR RESSEQ 116:118 OR (RESID      
REMARK   3                          119 AND (NAME N OR NAME CA OR NAME C OR     
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD2    
REMARK   3                          OR NAME CE2 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          (RESID 120 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2)) OR RESSEQ 121:123 OR (RESID 124 AND   
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD1 OR NAME      
REMARK   3                          CE1 OR NAME CZ )) OR RESSEQ 125:130 OR      
REMARK   3                          RESSEQ 132:141 OR (RESID 142 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR (RESID 143      
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME OD2)) OR    
REMARK   3                          RESSEQ 144:145 OR RESSEQ 147:150 OR         
REMARK   3                          (RESID 151 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 152:156 OR (RESID 157 AND (NAME   
REMARK   3                          N OR NAME CA OR NAME C OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME CD2)) OR RESSEQ      
REMARK   3                          158))                                       
REMARK   3     SELECTION          : (CHAIN B AND (RESSEQ 11:24 OR (RESID 26     
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME CD1)) OR    
REMARK   3                          RESSEQ 27:28 OR (RESID 29 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2)) OR RESSEQ 33:35 OR    
REMARK   3                          (RESID 36 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1)) OR RESSEQ 37:44 OR (RESID 45 AND      
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME OD1)) OR         
REMARK   3                          RESSEQ 46:55 OR (RESID 56 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2 OR NAME CE2 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR RESSEQ 57:58 OR         
REMARK   3                          (RESID 59 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 60:62 OR (RESID 63 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR RESSEQ 64:74    
REMARK   3                          OR (RESID 75 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 76:85 OR RESSEQ 90:    
REMARK   3                          92 OR (RESID 93 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 94:102 OR RESSEQ 104:  
REMARK   3                          114 OR (RESID 115 AND (NAME N OR NAME CA    
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD2 OR NAME CE2 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR RESSEQ 116:118 OR (RESID      
REMARK   3                          119 AND (NAME N OR NAME CA OR NAME C OR     
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD2    
REMARK   3                          OR NAME CE2 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          (RESID 120 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2)) OR RESSEQ 121:123 OR (RESID 124 AND   
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD1 OR NAME      
REMARK   3                          CE1 OR NAME CZ )) OR RESSEQ 125:130 OR      
REMARK   3                          RESSEQ 132:141 OR (RESID 142 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR (RESID 143      
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME OD2)) OR    
REMARK   3                          RESSEQ 144:145 OR RESSEQ 147:150 OR         
REMARK   3                          (RESID 151 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 152:156 OR (RESID 157 AND (NAME   
REMARK   3                          N OR NAME CA OR NAME C OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME CD2)) OR RESSEQ      
REMARK   3                          158))                                       
REMARK   3     ATOM PAIRS NUMBER  : 3735                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 2                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN A AND (RESSEQ 11:24 OR (RESID 26     
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME CD1)) OR    
REMARK   3                          RESSEQ 27:28 OR (RESID 29 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2)) OR RESSEQ 33:35 OR    
REMARK   3                          (RESID 36 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1)) OR RESSEQ 37:44 OR (RESID 45 AND      
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME OD1)) OR         
REMARK   3                          RESSEQ 46:55 OR (RESID 56 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2 OR NAME CE2 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR RESSEQ 57:58 OR         
REMARK   3                          (RESID 59 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 60:62 OR (RESID 63 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR RESSEQ 64:74    
REMARK   3                          OR (RESID 75 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 76:85 OR RESSEQ 90:    
REMARK   3                          92 OR (RESID 93 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 94:102 OR RESSEQ 104:  
REMARK   3                          114 OR (RESID 115 AND (NAME N OR NAME CA    
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD2 OR NAME CE2 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR RESSEQ 116:118 OR (RESID      
REMARK   3                          119 AND (NAME N OR NAME CA OR NAME C OR     
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD2    
REMARK   3                          OR NAME CE2 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          (RESID 120 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2)) OR RESSEQ 121:123 OR (RESID 124 AND   
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD1 OR NAME      
REMARK   3                          CE1 OR NAME CZ )) OR RESSEQ 125:130 OR      
REMARK   3                          RESSEQ 132:141 OR (RESID 142 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR (RESID 143      
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME OD2)) OR    
REMARK   3                          RESSEQ 144:145 OR RESSEQ 147:150 OR         
REMARK   3                          (RESID 151 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 152:156 OR (RESID 157 AND (NAME   
REMARK   3                          N OR NAME CA OR NAME C OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME CD2)) OR RESSEQ      
REMARK   3                          158))                                       
REMARK   3     SELECTION          : (CHAIN C AND (RESSEQ 11:24 OR (RESID 26     
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME CD1)) OR    
REMARK   3                          RESSEQ 27:28 OR (RESID 29 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2)) OR RESSEQ 33:35 OR    
REMARK   3                          (RESID 36 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1)) OR RESSEQ 37:44 OR (RESID 45 AND      
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME OD1)) OR         
REMARK   3                          RESSEQ 46:55 OR (RESID 56 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2 OR NAME CE2 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR RESSEQ 57:58 OR         
REMARK   3                          (RESID 59 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 60:62 OR (RESID 63 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR RESSEQ 64:74    
REMARK   3                          OR (RESID 75 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 76:85 OR RESSEQ 90:    
REMARK   3                          92 OR (RESID 93 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 94:102 OR RESSEQ 104:  
REMARK   3                          114 OR (RESID 115 AND (NAME N OR NAME CA    
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD2 OR NAME CE2 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR RESSEQ 116:118 OR (RESID      
REMARK   3                          119 AND (NAME N OR NAME CA OR NAME C OR     
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD2    
REMARK   3                          OR NAME CE2 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          (RESID 120 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2)) OR RESSEQ 121:123 OR (RESID 124 AND   
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD1 OR NAME      
REMARK   3                          CE1 OR NAME CZ )) OR RESSEQ 125:130 OR      
REMARK   3                          RESSEQ 132:141 OR (RESID 142 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR (RESID 143      
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME OD2)) OR    
REMARK   3                          RESSEQ 144:145 OR RESSEQ 147:150 OR         
REMARK   3                          (RESID 151 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 152:156 OR (RESID 157 AND (NAME   
REMARK   3                          O OR NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CD1)) OR RESSEQ 158)  
REMARK   3                          )                                           
REMARK   3     ATOM PAIRS NUMBER  : 3735                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 3                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN A AND (RESSEQ 11:24 OR (RESID 26     
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME CD1)) OR    
REMARK   3                          RESSEQ 27:28 OR (RESID 29 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2)) OR RESSEQ 33:35 OR    
REMARK   3                          (RESID 36 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1)) OR RESSEQ 37:44 OR (RESID 45 AND      
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME OD1)) OR         
REMARK   3                          RESSEQ 46:55 OR (RESID 56 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2 OR NAME CE2 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR RESSEQ 57:58 OR         
REMARK   3                          (RESID 59 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 60:62 OR (RESID 63 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR RESSEQ 64:74    
REMARK   3                          OR (RESID 75 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 76:85 OR RESSEQ 90:    
REMARK   3                          92 OR (RESID 93 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 94:102 OR RESSEQ 104:  
REMARK   3                          114 OR (RESID 115 AND (NAME N OR NAME CA    
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD2 OR NAME CE2 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR RESSEQ 116:118 OR (RESID      
REMARK   3                          119 AND (NAME N OR NAME CA OR NAME C OR     
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD2    
REMARK   3                          OR NAME CE2 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          (RESID 120 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2)) OR RESSEQ 121:123 OR (RESID 124 AND   
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD1 OR NAME      
REMARK   3                          CE1 OR NAME CZ )) OR RESSEQ 125:130 OR      
REMARK   3                          RESSEQ 132:141 OR (RESID 142 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR (RESID 143      
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME OD2)) OR    
REMARK   3                          RESSEQ 144:145 OR RESSEQ 147:150 OR         
REMARK   3                          (RESID 151 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 152:156 OR (RESID 157 AND (NAME   
REMARK   3                          N OR NAME CA OR NAME C OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME CD2)) OR RESSEQ      
REMARK   3                          158))                                       
REMARK   3     SELECTION          : (CHAIN J AND (RESSEQ 11:24 OR (RESID 26     
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME CD1)) OR    
REMARK   3                          RESSEQ 27:28 OR (RESID 29 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2)) OR RESSEQ 33:35 OR    
REMARK   3                          (RESID 36 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1)) OR RESSEQ 37:44 OR (RESID 45 AND      
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME OD1)) OR         
REMARK   3                          RESSEQ 46:55 OR (RESID 56 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2 OR NAME CE2 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR RESSEQ 57:58 OR         
REMARK   3                          (RESID 59 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 60:62 OR (RESID 63 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR RESSEQ 64:74    
REMARK   3                          OR (RESID 75 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 76:85 OR RESSEQ 90:    
REMARK   3                          92 OR (RESID 93 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 94:102 OR RESSEQ 104:  
REMARK   3                          114 OR (RESID 115 AND (NAME N OR NAME CA    
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD2 OR NAME CE2 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR RESSEQ 116:118 OR (RESID      
REMARK   3                          119 AND (NAME N OR NAME CA OR NAME C OR     
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD2    
REMARK   3                          OR NAME CE2 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          (RESID 120 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2)) OR RESSEQ 121:123 OR (RESID 124 AND   
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD1 OR NAME      
REMARK   3                          CE1 OR NAME CZ )) OR RESSEQ 125:130 OR      
REMARK   3                          RESSEQ 132:141 OR (RESID 142 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR (RESID 143      
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME OD2)) OR    
REMARK   3                          RESSEQ 144:145 OR RESSEQ 147:150 OR         
REMARK   3                          (RESID 151 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 152:156 OR (RESID 157 AND (NAME   
REMARK   3                          N OR NAME CA OR NAME C OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME CD2)) OR RESSEQ      
REMARK   3                          158))                                       
REMARK   3     ATOM PAIRS NUMBER  : 3735                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 4                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN A AND (RESSEQ 11:24 OR (RESID 26     
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME CD1)) OR    
REMARK   3                          RESSEQ 27:28 OR (RESID 29 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2)) OR RESSEQ 33:35 OR    
REMARK   3                          (RESID 36 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1)) OR RESSEQ 37:44 OR (RESID 45 AND      
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME OD1)) OR         
REMARK   3                          RESSEQ 46:55 OR (RESID 56 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2 OR NAME CE2 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR RESSEQ 57:58 OR         
REMARK   3                          (RESID 59 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 60:62 OR (RESID 63 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR RESSEQ 64:74    
REMARK   3                          OR (RESID 75 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 76:85 OR RESSEQ 90:    
REMARK   3                          92 OR (RESID 93 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 94:102 OR RESSEQ 104:  
REMARK   3                          114 OR (RESID 115 AND (NAME N OR NAME CA    
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD2 OR NAME CE2 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR RESSEQ 116:118 OR (RESID      
REMARK   3                          119 AND (NAME N OR NAME CA OR NAME C OR     
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD2    
REMARK   3                          OR NAME CE2 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          (RESID 120 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2)) OR RESSEQ 121:123 OR (RESID 124 AND   
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD1 OR NAME      
REMARK   3                          CE1 OR NAME CZ )) OR RESSEQ 125:130 OR      
REMARK   3                          RESSEQ 132:141 OR (RESID 142 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR (RESID 143      
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME OD2)) OR    
REMARK   3                          RESSEQ 144:145 OR RESSEQ 147:150 OR         
REMARK   3                          (RESID 151 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 152:156 OR (RESID 157 AND (NAME   
REMARK   3                          N OR NAME CA OR NAME C OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME CD2)) OR RESSEQ      
REMARK   3                          158))                                       
REMARK   3     SELECTION          : (CHAIN K AND (RESSEQ 11:24 OR (RESID 26     
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME CD1)) OR    
REMARK   3                          RESSEQ 27:28 OR (RESID 29 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2)) OR RESSEQ 33:35 OR    
REMARK   3                          (RESID 36 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1)) OR RESSEQ 37:44 OR (RESID 45 AND      
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME OD1)) OR         
REMARK   3                          RESSEQ 46:55 OR (RESID 56 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2 OR NAME CE2 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR RESSEQ 57:58 OR         
REMARK   3                          (RESID 59 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 60:62 OR (RESID 63 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR RESSEQ 64:74    
REMARK   3                          OR (RESID 75 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 76:85 OR RESSEQ 90:    
REMARK   3                          92 OR (RESID 93 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 94:102 OR RESSEQ 104:  
REMARK   3                          114 OR (RESID 115 AND (NAME N OR NAME CA    
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD2 OR NAME CE2 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR RESSEQ 116:118 OR (RESID      
REMARK   3                          119 AND (NAME N OR NAME CA OR NAME C OR     
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD2    
REMARK   3                          OR NAME CE2 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          (RESID 120 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2)) OR RESSEQ 121:123 OR (RESID 124 AND   
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD1 OR NAME      
REMARK   3                          CE1 OR NAME CZ )) OR RESSEQ 125:130 OR      
REMARK   3                          RESSEQ 132:141 OR (RESID 142 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR (RESID 143      
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME OD2)) OR    
REMARK   3                          RESSEQ 144:145 OR RESSEQ 147:150 OR         
REMARK   3                          (RESID 151 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 152:156 OR (RESID 157 AND (NAME   
REMARK   3                          N OR NAME CA OR NAME C OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME CD2)) OR RESSEQ      
REMARK   3                          158))                                       
REMARK   3     ATOM PAIRS NUMBER  : 3735                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 5                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN A AND (RESSEQ 11:24 OR (RESID 26     
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME CD1)) OR    
REMARK   3                          RESSEQ 27:28 OR (RESID 29 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2)) OR RESSEQ 33:35 OR    
REMARK   3                          (RESID 36 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1)) OR RESSEQ 37:44 OR (RESID 45 AND      
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME OD1)) OR         
REMARK   3                          RESSEQ 46:55 OR (RESID 56 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2 OR NAME CE2 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR RESSEQ 57:58 OR         
REMARK   3                          (RESID 59 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 60:62 OR (RESID 63 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR RESSEQ 64:74    
REMARK   3                          OR (RESID 75 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 76:85 OR RESSEQ 90:    
REMARK   3                          92 OR (RESID 93 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 94:102 OR RESSEQ 104:  
REMARK   3                          114 OR (RESID 115 AND (NAME N OR NAME CA    
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD2 OR NAME CE2 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR RESSEQ 116:118 OR (RESID      
REMARK   3                          119 AND (NAME N OR NAME CA OR NAME C OR     
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD2    
REMARK   3                          OR NAME CE2 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          (RESID 120 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2)) OR RESSEQ 121:123 OR (RESID 124 AND   
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD1 OR NAME      
REMARK   3                          CE1 OR NAME CZ )) OR RESSEQ 125:130 OR      
REMARK   3                          RESSEQ 132:141 OR (RESID 142 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR (RESID 143      
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME OD2)) OR    
REMARK   3                          RESSEQ 144:145 OR RESSEQ 147:150 OR         
REMARK   3                          (RESID 151 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 152:156 OR (RESID 157 AND (NAME   
REMARK   3                          N OR NAME CA OR NAME C OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME CD2)) OR RESSEQ      
REMARK   3                          158))                                       
REMARK   3     SELECTION          : (CHAIN L AND (RESSEQ 11:24 OR (RESID 26     
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME CD1)) OR    
REMARK   3                          RESSEQ 27:28 OR (RESID 29 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2)) OR RESSEQ 33:35 OR    
REMARK   3                          (RESID 36 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD1)) OR RESSEQ 37:44 OR (RESID 45 AND      
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME OD1)) OR         
REMARK   3                          RESSEQ 46:55 OR (RESID 56 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME C OR NAME O OR NAME CB OR   
REMARK   3                          NAME CG OR NAME CD2 OR NAME CE2 OR NAME     
REMARK   3                          CZ OR NAME OH )) OR RESSEQ 57:58 OR         
REMARK   3                          (RESID 59 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 60:62 OR (RESID 63 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR RESSEQ 64:74    
REMARK   3                          OR (RESID 75 AND (NAME N OR NAME CA OR      
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 76:85 OR RESSEQ 90:    
REMARK   3                          92 OR (RESID 93 AND (NAME N OR NAME CA OR   
REMARK   3                          NAME C OR NAME O OR NAME CB OR NAME CG OR   
REMARK   3                          NAME CD2)) OR RESSEQ 94:102 OR RESSEQ 104:  
REMARK   3                          114 OR (RESID 115 AND (NAME N OR NAME CA    
REMARK   3                          OR NAME C OR NAME O OR NAME CB OR NAME CG   
REMARK   3                          OR NAME CD2 OR NAME CE2 OR NAME CZ OR       
REMARK   3                          NAME OH )) OR RESSEQ 116:118 OR (RESID      
REMARK   3                          119 AND (NAME N OR NAME CA OR NAME C OR     
REMARK   3                          NAME O OR NAME CB OR NAME CG OR NAME CD2    
REMARK   3                          OR NAME CE2 OR NAME CZ OR NAME OH )) OR     
REMARK   3                          (RESID 120 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2)) OR RESSEQ 121:123 OR (RESID 124 AND   
REMARK   3                          (NAME N OR NAME CA OR NAME C OR NAME O OR   
REMARK   3                          NAME CB OR NAME CG OR NAME CD1 OR NAME      
REMARK   3                          CE1 OR NAME CZ )) OR RESSEQ 125:130 OR      
REMARK   3                          RESSEQ 132:141 OR (RESID 142 AND (NAME N    
REMARK   3                          OR NAME CA OR NAME C OR NAME O OR NAME CB   
REMARK   3                          OR NAME CG OR NAME CD2)) OR (RESID 143      
REMARK   3                          AND (NAME N OR NAME CA OR NAME C OR NAME    
REMARK   3                          O OR NAME CB OR NAME CG OR NAME OD2)) OR    
REMARK   3                          RESSEQ 144:145 OR RESSEQ 147:150 OR         
REMARK   3                          (RESID 151 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          CD2 OR NAME CE2 OR NAME CZ OR NAME OH ))    
REMARK   3                          OR RESSEQ 152:156 OR (RESID 157 AND (NAME   
REMARK   3                          N OR NAME CA OR NAME C OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME CD2)) OR RESSEQ      
REMARK   3                          158))                                       
REMARK   3     ATOM PAIRS NUMBER  : 3735                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3   NCS GROUP : 3                                                      
REMARK   3    NCS OPERATOR : 1                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN D AND (RESSEQ 1:10 OR (RESID 11      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD2 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 12:17 OR RESSEQ 19:29 OR (RESID 30   
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 31:48 OR (RESID 49      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 50:61 OR (RESID 62      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 63:69 OR (RESID 70 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME OD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 71:80 OR   
REMARK   3                          (RESID 82 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME OD1 OR NAME C OR      
REMARK   3                          NAME O )) OR (RESID 83 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 84:85 OR   
REMARK   3                          (RESID 86 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CZ OR NAME OH OR      
REMARK   3                          NAME C OR NAME O )) OR (RESID 87 AND        
REMARK   3                          (NAME N OR NAME CA OR NAME CB OR NAME CG    
REMARK   3                          OR NAME CZ OR NAME OH OR NAME C OR NAME O   
REMARK   3                          )) OR RESSEQ 88:103 OR RESSEQ 105 OR        
REMARK   3                          (RESID 106 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          OD1)) OR RESSEQ 107))                       
REMARK   3     SELECTION          : (CHAIN E AND (RESSEQ 1:10 OR (RESID 11      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD2 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 12:17 OR RESSEQ 19:29 OR (RESID 30   
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 31:48 OR (RESID 49      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 50:61 OR (RESID 62      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 63:69 OR (RESID 70 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME OD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 71:80 OR   
REMARK   3                          (RESID 82 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME OD1 OR NAME C OR      
REMARK   3                          NAME O )) OR (RESID 83 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 84:85 OR   
REMARK   3                          (RESID 86 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CZ OR NAME OH OR      
REMARK   3                          NAME C OR NAME O )) OR (RESID 87 AND        
REMARK   3                          (NAME N OR NAME CA OR NAME CB OR NAME CG    
REMARK   3                          OR NAME CZ OR NAME OH OR NAME C OR NAME O   
REMARK   3                          )) OR RESSEQ 88:103 OR RESSEQ 105 OR        
REMARK   3                          (RESID 106 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          OD1)) OR RESSEQ 107))                       
REMARK   3     ATOM PAIRS NUMBER  : 2851                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 2                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN D AND (RESSEQ 1:10 OR (RESID 11      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD2 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 12:17 OR RESSEQ 19:29 OR (RESID 30   
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 31:48 OR (RESID 49      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 50:61 OR (RESID 62      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 63:69 OR (RESID 70 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME OD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 71:80 OR   
REMARK   3                          (RESID 82 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME OD1 OR NAME C OR      
REMARK   3                          NAME O )) OR (RESID 83 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 84:85 OR   
REMARK   3                          (RESID 86 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CZ OR NAME OH OR      
REMARK   3                          NAME C OR NAME O )) OR (RESID 87 AND        
REMARK   3                          (NAME N OR NAME CA OR NAME CB OR NAME CG    
REMARK   3                          OR NAME CZ OR NAME OH OR NAME C OR NAME O   
REMARK   3                          )) OR RESSEQ 88:103 OR RESSEQ 105 OR        
REMARK   3                          (RESID 106 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          OD1)) OR RESSEQ 107))                       
REMARK   3     SELECTION          : (CHAIN F AND (RESSEQ 1:10 OR (RESID 11      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD2 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 12:17 OR RESSEQ 19:29 OR (RESID 30   
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 31:48 OR (RESID 49      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 50:61 OR (RESID 62      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 63:69 OR (RESID 70 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME OD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 71:80 OR   
REMARK   3                          (RESID 82 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME OD1 OR NAME C OR      
REMARK   3                          NAME O )) OR (RESID 83 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 84:85 OR   
REMARK   3                          (RESID 86 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CZ OR NAME OH OR      
REMARK   3                          NAME C OR NAME O )) OR (RESID 87 AND        
REMARK   3                          (NAME N OR NAME CA OR NAME CB OR NAME CG    
REMARK   3                          OR NAME CZ OR NAME OH OR NAME C OR NAME O   
REMARK   3                          )) OR RESSEQ 88:103 OR RESSEQ 105 OR        
REMARK   3                          (RESID 106 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          OD1)) OR RESSEQ 107))                       
REMARK   3     ATOM PAIRS NUMBER  : 2851                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 3                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN D AND (RESSEQ 1:10 OR (RESID 11      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD2 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 12:17 OR RESSEQ 19:29 OR (RESID 30   
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 31:48 OR (RESID 49      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 50:61 OR (RESID 62      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 63:69 OR (RESID 70 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME OD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 71:80 OR   
REMARK   3                          (RESID 82 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME OD1 OR NAME C OR      
REMARK   3                          NAME O )) OR (RESID 83 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 84:85 OR   
REMARK   3                          (RESID 86 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CZ OR NAME OH OR      
REMARK   3                          NAME C OR NAME O )) OR (RESID 87 AND        
REMARK   3                          (NAME N OR NAME CA OR NAME CB OR NAME CG    
REMARK   3                          OR NAME CZ OR NAME OH OR NAME C OR NAME O   
REMARK   3                          )) OR RESSEQ 88:103 OR RESSEQ 105 OR        
REMARK   3                          (RESID 106 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          OD1)) OR RESSEQ 107))                       
REMARK   3     SELECTION          : (CHAIN M AND (RESSEQ 1:10 OR (RESID 11      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD2 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 12:17 OR RESSEQ 19:29 OR (RESID 30   
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 31:48 OR (RESID 49      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 50:61 OR (RESID 62      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 63:69 OR (RESID 70 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME OD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 71:80 OR   
REMARK   3                          (RESID 82 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME OD1 OR NAME C OR      
REMARK   3                          NAME O )) OR (RESID 83 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 84:85 OR   
REMARK   3                          (RESID 86 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CZ OR NAME OH OR      
REMARK   3                          NAME C OR NAME O )) OR (RESID 87 AND        
REMARK   3                          (NAME N OR NAME CA OR NAME CB OR NAME CG    
REMARK   3                          OR NAME CZ OR NAME OH OR NAME C OR NAME O   
REMARK   3                          )) OR RESSEQ 88:103 OR RESSEQ 105 OR        
REMARK   3                          (RESID 106 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          OD1)) OR RESSEQ 107))                       
REMARK   3     ATOM PAIRS NUMBER  : 2851                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 4                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN D AND (RESSEQ 1:10 OR (RESID 11      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD2 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 12:17 OR RESSEQ 19:29 OR (RESID 30   
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 31:48 OR (RESID 49      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 50:61 OR (RESID 62      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 63:69 OR (RESID 70 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME OD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 71:80 OR   
REMARK   3                          (RESID 82 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME OD1 OR NAME C OR      
REMARK   3                          NAME O )) OR (RESID 83 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 84:85 OR   
REMARK   3                          (RESID 86 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CZ OR NAME OH OR      
REMARK   3                          NAME C OR NAME O )) OR (RESID 87 AND        
REMARK   3                          (NAME N OR NAME CA OR NAME CB OR NAME CG    
REMARK   3                          OR NAME CZ OR NAME OH OR NAME C OR NAME O   
REMARK   3                          )) OR RESSEQ 88:103 OR RESSEQ 105 OR        
REMARK   3                          (RESID 106 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          OD1)) OR RESSEQ 107))                       
REMARK   3     SELECTION          : (CHAIN N AND (RESSEQ 1:10 OR (RESID 11      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD2 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 12:17 OR RESSEQ 19:29 OR (RESID 30   
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 31:48 OR (RESID 49      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 50:61 OR (RESID 62      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 63:69 OR (RESID 70 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME OD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 71:80 OR   
REMARK   3                          (RESID 82 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME OD1 OR NAME C OR      
REMARK   3                          NAME O )) OR (RESID 83 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 84:85 OR   
REMARK   3                          (RESID 86 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CZ OR NAME OH OR      
REMARK   3                          NAME C OR NAME O )) OR (RESID 87 AND        
REMARK   3                          (NAME N OR NAME CA OR NAME CB OR NAME CG    
REMARK   3                          OR NAME CZ OR NAME OH OR NAME C OR NAME O   
REMARK   3                          )) OR RESSEQ 88:103 OR RESSEQ 105 OR        
REMARK   3                          (RESID 106 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          OD1)) OR RESSEQ 107))                       
REMARK   3     ATOM PAIRS NUMBER  : 2851                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3    NCS OPERATOR : 5                                                  
REMARK   3     REFERENCE SELECTION: (CHAIN D AND (RESSEQ 1:10 OR (RESID 11      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD2 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 12:17 OR RESSEQ 19:29 OR (RESID 30   
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 31:48 OR (RESID 49      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 50:61 OR (RESID 62      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 63:69 OR (RESID 70 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME OD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 71:80 OR   
REMARK   3                          (RESID 82 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME OD1 OR NAME C OR      
REMARK   3                          NAME O )) OR (RESID 83 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 84:85 OR   
REMARK   3                          (RESID 86 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CZ OR NAME OH OR      
REMARK   3                          NAME C OR NAME O )) OR (RESID 87 AND        
REMARK   3                          (NAME N OR NAME CA OR NAME CB OR NAME CG    
REMARK   3                          OR NAME CZ OR NAME OH OR NAME C OR NAME O   
REMARK   3                          )) OR RESSEQ 88:103 OR RESSEQ 105 OR        
REMARK   3                          (RESID 106 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          OD1)) OR RESSEQ 107))                       
REMARK   3     SELECTION          : (CHAIN O AND (RESSEQ 1:10 OR (RESID 11      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD2 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 12:17 OR RESSEQ 19:29 OR (RESID 30   
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 31:48 OR (RESID 49      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CZ OR NAME OH OR NAME C OR       
REMARK   3                          NAME O )) OR RESSEQ 50:61 OR (RESID 62      
REMARK   3                          AND (NAME N OR NAME CA OR NAME CB OR NAME   
REMARK   3                          CG OR NAME CD1 OR NAME C OR NAME O )) OR    
REMARK   3                          RESSEQ 63:69 OR (RESID 70 AND (NAME N OR    
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME OD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 71:80 OR   
REMARK   3                          (RESID 82 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME OD1 OR NAME C OR      
REMARK   3                          NAME O )) OR (RESID 83 AND (NAME N OR       
REMARK   3                          NAME CA OR NAME CB OR NAME CG OR NAME CD2   
REMARK   3                          OR NAME C OR NAME O )) OR RESSEQ 84:85 OR   
REMARK   3                          (RESID 86 AND (NAME N OR NAME CA OR NAME    
REMARK   3                          CB OR NAME CG OR NAME CZ OR NAME OH OR      
REMARK   3                          NAME C OR NAME O )) OR (RESID 87 AND        
REMARK   3                          (NAME N OR NAME CA OR NAME CB OR NAME CG    
REMARK   3                          OR NAME CZ OR NAME OH OR NAME C OR NAME O   
REMARK   3                          )) OR RESSEQ 88:103 OR RESSEQ 105 OR        
REMARK   3                          (RESID 106 AND (NAME N OR NAME CA OR NAME   
REMARK   3                          C OR NAME O OR NAME CB OR NAME CG OR NAME   
REMARK   3                          OD1)) OR RESSEQ 107))                       
REMARK   3     ATOM PAIRS NUMBER  : 2851                                        
REMARK   3     RMSD               : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 5YOY COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 01-NOV-17.                  
REMARK 100 THE DEPOSITION ID IS D_1300005643.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 08-OCT-16                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : SPRING-8                           
REMARK 200  BEAMLINE                       : BL41XU                             
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0                                
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS3 6M                
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XSCALE                             
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 77915                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.730                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 46.250                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000                             
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.1                               
REMARK 200  DATA REDUNDANCY                : 3.428                              
REMARK 200  R MERGE                    (I) : 0.10700                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 9.4700                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.73                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.80                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 92.8                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.52                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.98800                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 1.480                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 1A8M, 5B8C                                           
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 58.47                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.96                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M SODIUM ACETATE TRIHYDRATE PH 4.6,   
REMARK 280  1.4M SODIUM CHLORIDE, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE    
REMARK 280  293K                                                                
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y+1/2,-Z                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       42.65000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I             
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: J, K, L, M, N, O, P, Q, R             
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ASP A    -7                                                      
REMARK 465     TYR A    -6                                                      
REMARK 465     LYS A    -5                                                      
REMARK 465     ASP A    -4                                                      
REMARK 465     ASP A    -3                                                      
REMARK 465     ASP A    -2                                                      
REMARK 465     ASP A    -1                                                      
REMARK 465     LYS A     0                                                      
REMARK 465     VAL A     1                                                      
REMARK 465     ARG A     2                                                      
REMARK 465     SER A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     SER A     5                                                      
REMARK 465     GLU A   160                                                      
REMARK 465     ASN A   161                                                      
REMARK 465     LEU A   162                                                      
REMARK 465     TYR A   163                                                      
REMARK 465     PHE A   164                                                      
REMARK 465     GLN A   165                                                      
REMARK 465     ASP B    -7                                                      
REMARK 465     TYR B    -6                                                      
REMARK 465     LYS B    -5                                                      
REMARK 465     ASP B    -4                                                      
REMARK 465     ASP B    -3                                                      
REMARK 465     ASP B    -2                                                      
REMARK 465     ASP B    -1                                                      
REMARK 465     LYS B     0                                                      
REMARK 465     VAL B     1                                                      
REMARK 465     ARG B     2                                                      
REMARK 465     SER B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     SER B     5                                                      
REMARK 465     GLU B   160                                                      
REMARK 465     ASN B   161                                                      
REMARK 465     LEU B   162                                                      
REMARK 465     TYR B   163                                                      
REMARK 465     PHE B   164                                                      
REMARK 465     GLN B   165                                                      
REMARK 465     ASP C    -7                                                      
REMARK 465     TYR C    -6                                                      
REMARK 465     LYS C    -5                                                      
REMARK 465     ASP C    -4                                                      
REMARK 465     ASP C    -3                                                      
REMARK 465     ASP C    -2                                                      
REMARK 465     ASP C    -1                                                      
REMARK 465     LYS C     0                                                      
REMARK 465     VAL C     1                                                      
REMARK 465     ARG C     2                                                      
REMARK 465     SER C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     SER C     5                                                      
REMARK 465     GLU C   160                                                      
REMARK 465     ASN C   161                                                      
REMARK 465     LEU C   162                                                      
REMARK 465     TYR C   163                                                      
REMARK 465     PHE C   164                                                      
REMARK 465     GLN C   165                                                      
REMARK 465     ALA D    -2                                                      
REMARK 465     GLY D    -1                                                      
REMARK 465     SER D     0                                                      
REMARK 465     THR D   109                                                      
REMARK 465     SER D   110                                                      
REMARK 465     GLU D   111                                                      
REMARK 465     ASN D   112                                                      
REMARK 465     LEU D   113                                                      
REMARK 465     TYR D   114                                                      
REMARK 465     PHE D   115                                                      
REMARK 465     GLN D   116                                                      
REMARK 465     ALA E    -2                                                      
REMARK 465     GLY E    -1                                                      
REMARK 465     SER E     0                                                      
REMARK 465     THR E   109                                                      
REMARK 465     SER E   110                                                      
REMARK 465     GLU E   111                                                      
REMARK 465     ASN E   112                                                      
REMARK 465     LEU E   113                                                      
REMARK 465     TYR E   114                                                      
REMARK 465     PHE E   115                                                      
REMARK 465     GLN E   116                                                      
REMARK 465     ALA F    -2                                                      
REMARK 465     GLY F    -1                                                      
REMARK 465     SER F     0                                                      
REMARK 465     THR F   109                                                      
REMARK 465     SER F   110                                                      
REMARK 465     GLU F   111                                                      
REMARK 465     ASN F   112                                                      
REMARK 465     LEU F   113                                                      
REMARK 465     TYR F   114                                                      
REMARK 465     PHE F   115                                                      
REMARK 465     GLN F   116                                                      
REMARK 465     SER G    -2                                                      
REMARK 465     LYS G    -1                                                      
REMARK 465     LEU G     0                                                      
REMARK 465     SER H    -2                                                      
REMARK 465     LYS H    -1                                                      
REMARK 465     LEU H     0                                                      
REMARK 465     SER I    -2                                                      
REMARK 465     LYS I    -1                                                      
REMARK 465     LEU I     0                                                      
REMARK 465     SER I   126                                                      
REMARK 465     ASP J    -7                                                      
REMARK 465     TYR J    -6                                                      
REMARK 465     LYS J    -5                                                      
REMARK 465     ASP J    -4                                                      
REMARK 465     ASP J    -3                                                      
REMARK 465     ASP J    -2                                                      
REMARK 465     ASP J    -1                                                      
REMARK 465     LYS J     0                                                      
REMARK 465     VAL J     1                                                      
REMARK 465     ARG J     2                                                      
REMARK 465     SER J     3                                                      
REMARK 465     SER J     4                                                      
REMARK 465     SER J     5                                                      
REMARK 465     SER J   159                                                      
REMARK 465     GLU J   160                                                      
REMARK 465     ASN J   161                                                      
REMARK 465     LEU J   162                                                      
REMARK 465     TYR J   163                                                      
REMARK 465     PHE J   164                                                      
REMARK 465     GLN J   165                                                      
REMARK 465     ASP K    -7                                                      
REMARK 465     TYR K    -6                                                      
REMARK 465     LYS K    -5                                                      
REMARK 465     ASP K    -4                                                      
REMARK 465     ASP K    -3                                                      
REMARK 465     ASP K    -2                                                      
REMARK 465     ASP K    -1                                                      
REMARK 465     LYS K     0                                                      
REMARK 465     VAL K     1                                                      
REMARK 465     ARG K     2                                                      
REMARK 465     SER K     3                                                      
REMARK 465     SER K     4                                                      
REMARK 465     SER K     5                                                      
REMARK 465     SER K   159                                                      
REMARK 465     GLU K   160                                                      
REMARK 465     ASN K   161                                                      
REMARK 465     LEU K   162                                                      
REMARK 465     TYR K   163                                                      
REMARK 465     PHE K   164                                                      
REMARK 465     GLN K   165                                                      
REMARK 465     ASP L    -7                                                      
REMARK 465     TYR L    -6                                                      
REMARK 465     LYS L    -5                                                      
REMARK 465     ASP L    -4                                                      
REMARK 465     ASP L    -3                                                      
REMARK 465     ASP L    -2                                                      
REMARK 465     ASP L    -1                                                      
REMARK 465     LYS L     0                                                      
REMARK 465     VAL L     1                                                      
REMARK 465     ARG L     2                                                      
REMARK 465     SER L     3                                                      
REMARK 465     SER L     4                                                      
REMARK 465     SER L     5                                                      
REMARK 465     SER L   159                                                      
REMARK 465     GLU L   160                                                      
REMARK 465     ASN L   161                                                      
REMARK 465     LEU L   162                                                      
REMARK 465     TYR L   163                                                      
REMARK 465     PHE L   164                                                      
REMARK 465     GLN L   165                                                      
REMARK 465     ALA M    -2                                                      
REMARK 465     GLY M    -1                                                      
REMARK 465     SER M     0                                                      
REMARK 465     THR M   109                                                      
REMARK 465     SER M   110                                                      
REMARK 465     GLU M   111                                                      
REMARK 465     ASN M   112                                                      
REMARK 465     LEU M   113                                                      
REMARK 465     TYR M   114                                                      
REMARK 465     PHE M   115                                                      
REMARK 465     GLN M   116                                                      
REMARK 465     ALA N    -2                                                      
REMARK 465     GLY N    -1                                                      
REMARK 465     SER N     0                                                      
REMARK 465     THR N   109                                                      
REMARK 465     SER N   110                                                      
REMARK 465     GLU N   111                                                      
REMARK 465     ASN N   112                                                      
REMARK 465     LEU N   113                                                      
REMARK 465     TYR N   114                                                      
REMARK 465     PHE N   115                                                      
REMARK 465     GLN N   116                                                      
REMARK 465     ALA O    -2                                                      
REMARK 465     GLY O    -1                                                      
REMARK 465     SER O     0                                                      
REMARK 465     THR O   109                                                      
REMARK 465     SER O   110                                                      
REMARK 465     GLU O   111                                                      
REMARK 465     ASN O   112                                                      
REMARK 465     LEU O   113                                                      
REMARK 465     TYR O   114                                                      
REMARK 465     PHE O   115                                                      
REMARK 465     GLN O   116                                                      
REMARK 465     SER P    -2                                                      
REMARK 465     LYS P    -1                                                      
REMARK 465     LEU P     0                                                      
REMARK 465     SER Q    -2                                                      
REMARK 465     LYS Q    -1                                                      
REMARK 465     LEU Q     0                                                      
REMARK 465     SER R    -2                                                      
REMARK 465     LYS R    -1                                                      
REMARK 465     LEU R     0                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OD1  ASN K    30     O    HOH K   201              1.90            
REMARK 500   O    TRP B    28     O    HOH B   201              1.91            
REMARK 500   OE1  GLU G    46     O    HOH G   201              2.00            
REMARK 500   OG   SER D    65     O    HOH D   201              2.03            
REMARK 500   N    GLU N     1     O    HOH N   201              2.09            
REMARK 500   O    HOH A   201     O    HOH A   202              2.09            
REMARK 500   O    SER K   147     O    HOH K   202              2.11            
REMARK 500   O    HOH F   201     O    HOH I   201              2.17            
REMARK 500   O    VAL C    85     O    HOH C   201              2.18            
REMARK 500   O    GLU D     1     O    HOH D   202              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A  34       34.14     74.18                                   
REMARK 500    LEU A  37       92.26   -164.59                                   
REMARK 500    THR A  89     -147.93   -136.35                                   
REMARK 500    THR A 158      -86.53    -87.19                                   
REMARK 500    ARG B  31        7.14    -66.05                                   
REMARK 500    ASN B  34       31.92     75.13                                   
REMARK 500    LEU B  37       89.45   -165.36                                   
REMARK 500    SER B  86        6.13     57.06                                   
REMARK 500    PRO C   8     -173.82    -67.43                                   
REMARK 500    SER C   9       46.71    -82.85                                   
REMARK 500    ASP C  10       15.14     59.67                                   
REMARK 500    ASN C  34       32.54     71.15                                   
REMARK 500    LEU C  37       89.29   -165.11                                   
REMARK 500    TYR D  30     -122.77     56.31                                   
REMARK 500    ALA D  51      -52.38     71.35                                   
REMARK 500    ALA D  84     -169.58   -161.08                                   
REMARK 500    TYR E  30     -122.96     55.76                                   
REMARK 500    ALA E  51      -51.57     70.94                                   
REMARK 500    ALA E  84     -168.93   -160.71                                   
REMARK 500    TYR F  30     -123.96     57.08                                   
REMARK 500    ALA F  51      -52.88     71.83                                   
REMARK 500    ALA F  84     -168.20   -161.81                                   
REMARK 500    TYR G 111     -144.05     58.62                                   
REMARK 500    TYR H 111     -145.63     57.40                                   
REMARK 500    VAL H 124       78.57   -108.84                                   
REMARK 500    SER H 125     -166.22    -78.42                                   
REMARK 500    TYR I 111     -146.01     59.24                                   
REMARK 500    ASP J  10       85.07    -64.51                                   
REMARK 500    ASN J  34       32.67     70.94                                   
REMARK 500    LEU J  37       89.80   -165.28                                   
REMARK 500    ASN K  34       34.52     74.15                                   
REMARK 500    LEU K  37       88.06   -167.17                                   
REMARK 500    LYS L  11      128.82   -179.41                                   
REMARK 500    LEU L  37       89.31   -165.36                                   
REMARK 500    TYR M  30     -121.68     57.87                                   
REMARK 500    ALA M  51      -52.07     72.31                                   
REMARK 500    ALA M  84     -168.30   -161.78                                   
REMARK 500    TYR N  30     -124.46     55.57                                   
REMARK 500    ALA N  51      -51.47     70.48                                   
REMARK 500    ALA N  84     -167.95   -161.01                                   
REMARK 500    TYR O  30     -123.06     56.57                                   
REMARK 500    ALA O  51      -53.27     71.43                                   
REMARK 500    TYR P 111     -145.10     58.83                                   
REMARK 500    TYR Q 111     -146.89     57.14                                   
REMARK 500    VAL Q 124       73.06   -108.67                                   
REMARK 500    TYR R 111     -144.41     59.63                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 AUTHORS STATE THAT 158THR/159SER ARE DUE TO RISTRICTION ENZYME, AND  
REMARK 999 160GLU/161ASN/162LEU/163TYR/164PHE/165GLN ARE DUE TO PROTEASE        
REMARK 999 CLEAVAGE.                                                            
DBREF  5YOY A    1   157  UNP    P01375   TNFA_HUMAN      77    233             
DBREF  5YOY B    1   157  UNP    P01375   TNFA_HUMAN      77    233             
DBREF  5YOY C    1   157  UNP    P01375   TNFA_HUMAN      77    233             
DBREF  5YOY D   -2   116  PDB    5YOY     5YOY            -2    116             
DBREF  5YOY E   -2   116  PDB    5YOY     5YOY            -2    116             
DBREF  5YOY F   -2   116  PDB    5YOY     5YOY            -2    116             
DBREF  5YOY G   -2   126  PDB    5YOY     5YOY            -2    126             
DBREF  5YOY H   -2   126  PDB    5YOY     5YOY            -2    126             
DBREF  5YOY I   -2   126  PDB    5YOY     5YOY            -2    126             
DBREF  5YOY J    1   157  UNP    P01375   TNFA_HUMAN      77    233             
DBREF  5YOY K    1   157  UNP    P01375   TNFA_HUMAN      77    233             
DBREF  5YOY L    1   157  UNP    P01375   TNFA_HUMAN      77    233             
DBREF  5YOY M   -2   116  PDB    5YOY     5YOY            -2    116             
DBREF  5YOY N   -2   116  PDB    5YOY     5YOY            -2    116             
DBREF  5YOY O   -2   116  PDB    5YOY     5YOY            -2    116             
DBREF  5YOY P   -2   126  PDB    5YOY     5YOY            -2    126             
DBREF  5YOY Q   -2   126  PDB    5YOY     5YOY            -2    126             
DBREF  5YOY R   -2   126  PDB    5YOY     5YOY            -2    126             
SEQADV 5YOY ASP A   -7  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY TYR A   -6  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS A   -5  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP A   -4  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP A   -3  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP A   -2  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP A   -1  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS A    0  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY THR A  158  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY SER A  159  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLU A  160  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASN A  161  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY LEU A  162  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY TYR A  163  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY PHE A  164  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLN A  165  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASP B   -7  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY TYR B   -6  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS B   -5  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP B   -4  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP B   -3  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP B   -2  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP B   -1  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS B    0  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY THR B  158  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY SER B  159  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLU B  160  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASN B  161  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY LEU B  162  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY TYR B  163  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY PHE B  164  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLN B  165  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASP C   -7  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY TYR C   -6  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS C   -5  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP C   -4  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP C   -3  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP C   -2  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP C   -1  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS C    0  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY THR C  158  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY SER C  159  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLU C  160  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASN C  161  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY LEU C  162  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY TYR C  163  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY PHE C  164  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLN C  165  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASP J   -7  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY TYR J   -6  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS J   -5  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP J   -4  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP J   -3  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP J   -2  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP J   -1  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS J    0  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY THR J  158  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY SER J  159  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLU J  160  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASN J  161  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY LEU J  162  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY TYR J  163  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY PHE J  164  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLN J  165  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASP K   -7  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY TYR K   -6  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS K   -5  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP K   -4  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP K   -3  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP K   -2  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP K   -1  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS K    0  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY THR K  158  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY SER K  159  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLU K  160  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASN K  161  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY LEU K  162  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY TYR K  163  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY PHE K  164  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLN K  165  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASP L   -7  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY TYR L   -6  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS L   -5  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP L   -4  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP L   -3  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP L   -2  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY ASP L   -1  UNP  P01375              EXPRESSION TAG                 
SEQADV 5YOY LYS L    0  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY THR L  158  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY SER L  159  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLU L  160  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY ASN L  161  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY LEU L  162  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY TYR L  163  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY PHE L  164  UNP  P01375              CLONING ARTIFACT               
SEQADV 5YOY GLN L  165  UNP  P01375              CLONING ARTIFACT               
SEQRES   1 A  173  ASP TYR LYS ASP ASP ASP ASP LYS VAL ARG SER SER SER          
SEQRES   2 A  173  ARG THR PRO SER ASP LYS PRO VAL ALA HIS VAL VAL ALA          
SEQRES   3 A  173  ASN PRO GLN ALA GLU GLY GLN LEU GLN TRP LEU ASN ARG          
SEQRES   4 A  173  ARG ALA ASN ALA LEU LEU ALA ASN GLY VAL GLU LEU ARG          
SEQRES   5 A  173  ASP ASN GLN LEU VAL VAL PRO SER GLU GLY LEU TYR LEU          
SEQRES   6 A  173  ILE TYR SER GLN VAL LEU PHE LYS GLY GLN GLY CYS PRO          
SEQRES   7 A  173  SER THR HIS VAL LEU LEU THR HIS THR ILE SER ARG ILE          
SEQRES   8 A  173  ALA VAL SER TYR GLN THR LYS VAL ASN LEU LEU SER ALA          
SEQRES   9 A  173  ILE LYS SER PRO CYS GLN ARG GLU THR PRO GLU GLY ALA          
SEQRES  10 A  173  GLU ALA LYS PRO TRP TYR GLU PRO ILE TYR LEU GLY GLY          
SEQRES  11 A  173  VAL PHE GLN LEU GLU LYS GLY ASP ARG LEU SER ALA GLU          
SEQRES  12 A  173  ILE ASN ARG PRO ASP TYR LEU ASP PHE ALA GLU SER GLY          
SEQRES  13 A  173  GLN VAL TYR PHE GLY ILE ILE ALA LEU THR SER GLU ASN          
SEQRES  14 A  173  LEU TYR PHE GLN                                              
SEQRES   1 B  173  ASP TYR LYS ASP ASP ASP ASP LYS VAL ARG SER SER SER          
SEQRES   2 B  173  ARG THR PRO SER ASP LYS PRO VAL ALA HIS VAL VAL ALA          
SEQRES   3 B  173  ASN PRO GLN ALA GLU GLY GLN LEU GLN TRP LEU ASN ARG          
SEQRES   4 B  173  ARG ALA ASN ALA LEU LEU ALA ASN GLY VAL GLU LEU ARG          
SEQRES   5 B  173  ASP ASN GLN LEU VAL VAL PRO SER GLU GLY LEU TYR LEU          
SEQRES   6 B  173  ILE TYR SER GLN VAL LEU PHE LYS GLY GLN GLY CYS PRO          
SEQRES   7 B  173  SER THR HIS VAL LEU LEU THR HIS THR ILE SER ARG ILE          
SEQRES   8 B  173  ALA VAL SER TYR GLN THR LYS VAL ASN LEU LEU SER ALA          
SEQRES   9 B  173  ILE LYS SER PRO CYS GLN ARG GLU THR PRO GLU GLY ALA          
SEQRES  10 B  173  GLU ALA LYS PRO TRP TYR GLU PRO ILE TYR LEU GLY GLY          
SEQRES  11 B  173  VAL PHE GLN LEU GLU LYS GLY ASP ARG LEU SER ALA GLU          
SEQRES  12 B  173  ILE ASN ARG PRO ASP TYR LEU ASP PHE ALA GLU SER GLY          
SEQRES  13 B  173  GLN VAL TYR PHE GLY ILE ILE ALA LEU THR SER GLU ASN          
SEQRES  14 B  173  LEU TYR PHE GLN                                              
SEQRES   1 C  173  ASP TYR LYS ASP ASP ASP ASP LYS VAL ARG SER SER SER          
SEQRES   2 C  173  ARG THR PRO SER ASP LYS PRO VAL ALA HIS VAL VAL ALA          
SEQRES   3 C  173  ASN PRO GLN ALA GLU GLY GLN LEU GLN TRP LEU ASN ARG          
SEQRES   4 C  173  ARG ALA ASN ALA LEU LEU ALA ASN GLY VAL GLU LEU ARG          
SEQRES   5 C  173  ASP ASN GLN LEU VAL VAL PRO SER GLU GLY LEU TYR LEU          
SEQRES   6 C  173  ILE TYR SER GLN VAL LEU PHE LYS GLY GLN GLY CYS PRO          
SEQRES   7 C  173  SER THR HIS VAL LEU LEU THR HIS THR ILE SER ARG ILE          
SEQRES   8 C  173  ALA VAL SER TYR GLN THR LYS VAL ASN LEU LEU SER ALA          
SEQRES   9 C  173  ILE LYS SER PRO CYS GLN ARG GLU THR PRO GLU GLY ALA          
SEQRES  10 C  173  GLU ALA LYS PRO TRP TYR GLU PRO ILE TYR LEU GLY GLY          
SEQRES  11 C  173  VAL PHE GLN LEU GLU LYS GLY ASP ARG LEU SER ALA GLU          
SEQRES  12 C  173  ILE ASN ARG PRO ASP TYR LEU ASP PHE ALA GLU SER GLY          
SEQRES  13 C  173  GLN VAL TYR PHE GLY ILE ILE ALA LEU THR SER GLU ASN          
SEQRES  14 C  173  LEU TYR PHE GLN                                              
SEQRES   1 D  119  ALA GLY SER GLU ILE VAL LEU THR GLN SER PRO ALA THR          
SEQRES   2 D  119  LEU SER LEU SER PRO GLY GLU ARG ALA THR LEU SER CYS          
SEQRES   3 D  119  ARG ALA SER GLN SER VAL TYR SER TYR LEU ALA TRP TYR          
SEQRES   4 D  119  GLN GLN LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR          
SEQRES   5 D  119  ASP ALA SER ASN ARG ALA THR GLY ILE PRO ALA ARG PHE          
SEQRES   6 D  119  SER GLY SER GLY SER GLY THR ASP PHE THR LEU THR ILE          
SEQRES   7 D  119  SER SER LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS          
SEQRES   8 D  119  GLN GLN ARG SER ASN TRP PRO PRO PHE THR PHE GLY PRO          
SEQRES   9 D  119  GLY THR LYS VAL ASP ILE LYS THR SER GLU ASN LEU TYR          
SEQRES  10 D  119  PHE GLN                                                      
SEQRES   1 E  119  ALA GLY SER GLU ILE VAL LEU THR GLN SER PRO ALA THR          
SEQRES   2 E  119  LEU SER LEU SER PRO GLY GLU ARG ALA THR LEU SER CYS          
SEQRES   3 E  119  ARG ALA SER GLN SER VAL TYR SER TYR LEU ALA TRP TYR          
SEQRES   4 E  119  GLN GLN LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR          
SEQRES   5 E  119  ASP ALA SER ASN ARG ALA THR GLY ILE PRO ALA ARG PHE          
SEQRES   6 E  119  SER GLY SER GLY SER GLY THR ASP PHE THR LEU THR ILE          
SEQRES   7 E  119  SER SER LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS          
SEQRES   8 E  119  GLN GLN ARG SER ASN TRP PRO PRO PHE THR PHE GLY PRO          
SEQRES   9 E  119  GLY THR LYS VAL ASP ILE LYS THR SER GLU ASN LEU TYR          
SEQRES  10 E  119  PHE GLN                                                      
SEQRES   1 F  119  ALA GLY SER GLU ILE VAL LEU THR GLN SER PRO ALA THR          
SEQRES   2 F  119  LEU SER LEU SER PRO GLY GLU ARG ALA THR LEU SER CYS          
SEQRES   3 F  119  ARG ALA SER GLN SER VAL TYR SER TYR LEU ALA TRP TYR          
SEQRES   4 F  119  GLN GLN LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR          
SEQRES   5 F  119  ASP ALA SER ASN ARG ALA THR GLY ILE PRO ALA ARG PHE          
SEQRES   6 F  119  SER GLY SER GLY SER GLY THR ASP PHE THR LEU THR ILE          
SEQRES   7 F  119  SER SER LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS          
SEQRES   8 F  119  GLN GLN ARG SER ASN TRP PRO PRO PHE THR PHE GLY PRO          
SEQRES   9 F  119  GLY THR LYS VAL ASP ILE LYS THR SER GLU ASN LEU TYR          
SEQRES  10 F  119  PHE GLN                                                      
SEQRES   1 G  129  SER LYS LEU GLN VAL GLN LEU VAL GLU SER GLY GLY GLY          
SEQRES   2 G  129  VAL VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS ALA          
SEQRES   3 G  129  ALA SER GLY PHE ILE PHE SER SER TYR ALA MET HIS TRP          
SEQRES   4 G  129  VAL ARG GLN ALA PRO GLY ASN GLY LEU GLU TRP VAL ALA          
SEQRES   5 G  129  PHE MET SER TYR ASP GLY SER ASN LYS LYS TYR ALA ASP          
SEQRES   6 G  129  SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SER          
SEQRES   7 G  129  LYS ASN THR LEU TYR LEU GLN MET ASN SER LEU ARG ALA          
SEQRES   8 G  129  GLU ASP THR ALA VAL TYR TYR CYS ALA ARG ASP ARG GLY          
SEQRES   9 G  129  ILE ALA ALA GLY GLY ASN TYR TYR TYR TYR GLY MET ASP          
SEQRES  10 G  129  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER              
SEQRES   1 H  129  SER LYS LEU GLN VAL GLN LEU VAL GLU SER GLY GLY GLY          
SEQRES   2 H  129  VAL VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS ALA          
SEQRES   3 H  129  ALA SER GLY PHE ILE PHE SER SER TYR ALA MET HIS TRP          
SEQRES   4 H  129  VAL ARG GLN ALA PRO GLY ASN GLY LEU GLU TRP VAL ALA          
SEQRES   5 H  129  PHE MET SER TYR ASP GLY SER ASN LYS LYS TYR ALA ASP          
SEQRES   6 H  129  SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SER          
SEQRES   7 H  129  LYS ASN THR LEU TYR LEU GLN MET ASN SER LEU ARG ALA          
SEQRES   8 H  129  GLU ASP THR ALA VAL TYR TYR CYS ALA ARG ASP ARG GLY          
SEQRES   9 H  129  ILE ALA ALA GLY GLY ASN TYR TYR TYR TYR GLY MET ASP          
SEQRES  10 H  129  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER              
SEQRES   1 I  129  SER LYS LEU GLN VAL GLN LEU VAL GLU SER GLY GLY GLY          
SEQRES   2 I  129  VAL VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS ALA          
SEQRES   3 I  129  ALA SER GLY PHE ILE PHE SER SER TYR ALA MET HIS TRP          
SEQRES   4 I  129  VAL ARG GLN ALA PRO GLY ASN GLY LEU GLU TRP VAL ALA          
SEQRES   5 I  129  PHE MET SER TYR ASP GLY SER ASN LYS LYS TYR ALA ASP          
SEQRES   6 I  129  SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SER          
SEQRES   7 I  129  LYS ASN THR LEU TYR LEU GLN MET ASN SER LEU ARG ALA          
SEQRES   8 I  129  GLU ASP THR ALA VAL TYR TYR CYS ALA ARG ASP ARG GLY          
SEQRES   9 I  129  ILE ALA ALA GLY GLY ASN TYR TYR TYR TYR GLY MET ASP          
SEQRES  10 I  129  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER              
SEQRES   1 J  173  ASP TYR LYS ASP ASP ASP ASP LYS VAL ARG SER SER SER          
SEQRES   2 J  173  ARG THR PRO SER ASP LYS PRO VAL ALA HIS VAL VAL ALA          
SEQRES   3 J  173  ASN PRO GLN ALA GLU GLY GLN LEU GLN TRP LEU ASN ARG          
SEQRES   4 J  173  ARG ALA ASN ALA LEU LEU ALA ASN GLY VAL GLU LEU ARG          
SEQRES   5 J  173  ASP ASN GLN LEU VAL VAL PRO SER GLU GLY LEU TYR LEU          
SEQRES   6 J  173  ILE TYR SER GLN VAL LEU PHE LYS GLY GLN GLY CYS PRO          
SEQRES   7 J  173  SER THR HIS VAL LEU LEU THR HIS THR ILE SER ARG ILE          
SEQRES   8 J  173  ALA VAL SER TYR GLN THR LYS VAL ASN LEU LEU SER ALA          
SEQRES   9 J  173  ILE LYS SER PRO CYS GLN ARG GLU THR PRO GLU GLY ALA          
SEQRES  10 J  173  GLU ALA LYS PRO TRP TYR GLU PRO ILE TYR LEU GLY GLY          
SEQRES  11 J  173  VAL PHE GLN LEU GLU LYS GLY ASP ARG LEU SER ALA GLU          
SEQRES  12 J  173  ILE ASN ARG PRO ASP TYR LEU ASP PHE ALA GLU SER GLY          
SEQRES  13 J  173  GLN VAL TYR PHE GLY ILE ILE ALA LEU THR SER GLU ASN          
SEQRES  14 J  173  LEU TYR PHE GLN                                              
SEQRES   1 K  173  ASP TYR LYS ASP ASP ASP ASP LYS VAL ARG SER SER SER          
SEQRES   2 K  173  ARG THR PRO SER ASP LYS PRO VAL ALA HIS VAL VAL ALA          
SEQRES   3 K  173  ASN PRO GLN ALA GLU GLY GLN LEU GLN TRP LEU ASN ARG          
SEQRES   4 K  173  ARG ALA ASN ALA LEU LEU ALA ASN GLY VAL GLU LEU ARG          
SEQRES   5 K  173  ASP ASN GLN LEU VAL VAL PRO SER GLU GLY LEU TYR LEU          
SEQRES   6 K  173  ILE TYR SER GLN VAL LEU PHE LYS GLY GLN GLY CYS PRO          
SEQRES   7 K  173  SER THR HIS VAL LEU LEU THR HIS THR ILE SER ARG ILE          
SEQRES   8 K  173  ALA VAL SER TYR GLN THR LYS VAL ASN LEU LEU SER ALA          
SEQRES   9 K  173  ILE LYS SER PRO CYS GLN ARG GLU THR PRO GLU GLY ALA          
SEQRES  10 K  173  GLU ALA LYS PRO TRP TYR GLU PRO ILE TYR LEU GLY GLY          
SEQRES  11 K  173  VAL PHE GLN LEU GLU LYS GLY ASP ARG LEU SER ALA GLU          
SEQRES  12 K  173  ILE ASN ARG PRO ASP TYR LEU ASP PHE ALA GLU SER GLY          
SEQRES  13 K  173  GLN VAL TYR PHE GLY ILE ILE ALA LEU THR SER GLU ASN          
SEQRES  14 K  173  LEU TYR PHE GLN                                              
SEQRES   1 L  173  ASP TYR LYS ASP ASP ASP ASP LYS VAL ARG SER SER SER          
SEQRES   2 L  173  ARG THR PRO SER ASP LYS PRO VAL ALA HIS VAL VAL ALA          
SEQRES   3 L  173  ASN PRO GLN ALA GLU GLY GLN LEU GLN TRP LEU ASN ARG          
SEQRES   4 L  173  ARG ALA ASN ALA LEU LEU ALA ASN GLY VAL GLU LEU ARG          
SEQRES   5 L  173  ASP ASN GLN LEU VAL VAL PRO SER GLU GLY LEU TYR LEU          
SEQRES   6 L  173  ILE TYR SER GLN VAL LEU PHE LYS GLY GLN GLY CYS PRO          
SEQRES   7 L  173  SER THR HIS VAL LEU LEU THR HIS THR ILE SER ARG ILE          
SEQRES   8 L  173  ALA VAL SER TYR GLN THR LYS VAL ASN LEU LEU SER ALA          
SEQRES   9 L  173  ILE LYS SER PRO CYS GLN ARG GLU THR PRO GLU GLY ALA          
SEQRES  10 L  173  GLU ALA LYS PRO TRP TYR GLU PRO ILE TYR LEU GLY GLY          
SEQRES  11 L  173  VAL PHE GLN LEU GLU LYS GLY ASP ARG LEU SER ALA GLU          
SEQRES  12 L  173  ILE ASN ARG PRO ASP TYR LEU ASP PHE ALA GLU SER GLY          
SEQRES  13 L  173  GLN VAL TYR PHE GLY ILE ILE ALA LEU THR SER GLU ASN          
SEQRES  14 L  173  LEU TYR PHE GLN                                              
SEQRES   1 M  119  ALA GLY SER GLU ILE VAL LEU THR GLN SER PRO ALA THR          
SEQRES   2 M  119  LEU SER LEU SER PRO GLY GLU ARG ALA THR LEU SER CYS          
SEQRES   3 M  119  ARG ALA SER GLN SER VAL TYR SER TYR LEU ALA TRP TYR          
SEQRES   4 M  119  GLN GLN LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR          
SEQRES   5 M  119  ASP ALA SER ASN ARG ALA THR GLY ILE PRO ALA ARG PHE          
SEQRES   6 M  119  SER GLY SER GLY SER GLY THR ASP PHE THR LEU THR ILE          
SEQRES   7 M  119  SER SER LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS          
SEQRES   8 M  119  GLN GLN ARG SER ASN TRP PRO PRO PHE THR PHE GLY PRO          
SEQRES   9 M  119  GLY THR LYS VAL ASP ILE LYS THR SER GLU ASN LEU TYR          
SEQRES  10 M  119  PHE GLN                                                      
SEQRES   1 N  119  ALA GLY SER GLU ILE VAL LEU THR GLN SER PRO ALA THR          
SEQRES   2 N  119  LEU SER LEU SER PRO GLY GLU ARG ALA THR LEU SER CYS          
SEQRES   3 N  119  ARG ALA SER GLN SER VAL TYR SER TYR LEU ALA TRP TYR          
SEQRES   4 N  119  GLN GLN LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR          
SEQRES   5 N  119  ASP ALA SER ASN ARG ALA THR GLY ILE PRO ALA ARG PHE          
SEQRES   6 N  119  SER GLY SER GLY SER GLY THR ASP PHE THR LEU THR ILE          
SEQRES   7 N  119  SER SER LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS          
SEQRES   8 N  119  GLN GLN ARG SER ASN TRP PRO PRO PHE THR PHE GLY PRO          
SEQRES   9 N  119  GLY THR LYS VAL ASP ILE LYS THR SER GLU ASN LEU TYR          
SEQRES  10 N  119  PHE GLN                                                      
SEQRES   1 O  119  ALA GLY SER GLU ILE VAL LEU THR GLN SER PRO ALA THR          
SEQRES   2 O  119  LEU SER LEU SER PRO GLY GLU ARG ALA THR LEU SER CYS          
SEQRES   3 O  119  ARG ALA SER GLN SER VAL TYR SER TYR LEU ALA TRP TYR          
SEQRES   4 O  119  GLN GLN LYS PRO GLY GLN ALA PRO ARG LEU LEU ILE TYR          
SEQRES   5 O  119  ASP ALA SER ASN ARG ALA THR GLY ILE PRO ALA ARG PHE          
SEQRES   6 O  119  SER GLY SER GLY SER GLY THR ASP PHE THR LEU THR ILE          
SEQRES   7 O  119  SER SER LEU GLU PRO GLU ASP PHE ALA VAL TYR TYR CYS          
SEQRES   8 O  119  GLN GLN ARG SER ASN TRP PRO PRO PHE THR PHE GLY PRO          
SEQRES   9 O  119  GLY THR LYS VAL ASP ILE LYS THR SER GLU ASN LEU TYR          
SEQRES  10 O  119  PHE GLN                                                      
SEQRES   1 P  129  SER LYS LEU GLN VAL GLN LEU VAL GLU SER GLY GLY GLY          
SEQRES   2 P  129  VAL VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS ALA          
SEQRES   3 P  129  ALA SER GLY PHE ILE PHE SER SER TYR ALA MET HIS TRP          
SEQRES   4 P  129  VAL ARG GLN ALA PRO GLY ASN GLY LEU GLU TRP VAL ALA          
SEQRES   5 P  129  PHE MET SER TYR ASP GLY SER ASN LYS LYS TYR ALA ASP          
SEQRES   6 P  129  SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SER          
SEQRES   7 P  129  LYS ASN THR LEU TYR LEU GLN MET ASN SER LEU ARG ALA          
SEQRES   8 P  129  GLU ASP THR ALA VAL TYR TYR CYS ALA ARG ASP ARG GLY          
SEQRES   9 P  129  ILE ALA ALA GLY GLY ASN TYR TYR TYR TYR GLY MET ASP          
SEQRES  10 P  129  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER              
SEQRES   1 Q  129  SER LYS LEU GLN VAL GLN LEU VAL GLU SER GLY GLY GLY          
SEQRES   2 Q  129  VAL VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS ALA          
SEQRES   3 Q  129  ALA SER GLY PHE ILE PHE SER SER TYR ALA MET HIS TRP          
SEQRES   4 Q  129  VAL ARG GLN ALA PRO GLY ASN GLY LEU GLU TRP VAL ALA          
SEQRES   5 Q  129  PHE MET SER TYR ASP GLY SER ASN LYS LYS TYR ALA ASP          
SEQRES   6 Q  129  SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SER          
SEQRES   7 Q  129  LYS ASN THR LEU TYR LEU GLN MET ASN SER LEU ARG ALA          
SEQRES   8 Q  129  GLU ASP THR ALA VAL TYR TYR CYS ALA ARG ASP ARG GLY          
SEQRES   9 Q  129  ILE ALA ALA GLY GLY ASN TYR TYR TYR TYR GLY MET ASP          
SEQRES  10 Q  129  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER              
SEQRES   1 R  129  SER LYS LEU GLN VAL GLN LEU VAL GLU SER GLY GLY GLY          
SEQRES   2 R  129  VAL VAL GLN PRO GLY ARG SER LEU ARG LEU SER CYS ALA          
SEQRES   3 R  129  ALA SER GLY PHE ILE PHE SER SER TYR ALA MET HIS TRP          
SEQRES   4 R  129  VAL ARG GLN ALA PRO GLY ASN GLY LEU GLU TRP VAL ALA          
SEQRES   5 R  129  PHE MET SER TYR ASP GLY SER ASN LYS LYS TYR ALA ASP          
SEQRES   6 R  129  SER VAL LYS GLY ARG PHE THR ILE SER ARG ASP ASN SER          
SEQRES   7 R  129  LYS ASN THR LEU TYR LEU GLN MET ASN SER LEU ARG ALA          
SEQRES   8 R  129  GLU ASP THR ALA VAL TYR TYR CYS ALA ARG ASP ARG GLY          
SEQRES   9 R  129  ILE ALA ALA GLY GLY ASN TYR TYR TYR TYR GLY MET ASP          
SEQRES  10 R  129  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER              
FORMUL  19  HOH   *86(H2 O)                                                     
HELIX    1 AA1 ARG A  138  LEU A  142  5                                   5    
HELIX    2 AA2 GLU A  146  GLN A  149  5                                   4    
HELIX    3 AA3 ARG B  138  LEU B  142  5                                   5    
HELIX    4 AA4 GLU B  146  GLN B  149  5                                   4    
HELIX    5 AA5 ARG C  138  LEU C  142  5                                   5    
HELIX    6 AA6 GLU C  146  GLN C  149  5                                   4    
HELIX    7 AA7 GLU D   79  PHE D   83  5                                   5    
HELIX    8 AA8 GLU F   79  PHE F   83  5                                   5    
HELIX    9 AA9 ILE G   28  TYR G   32  5                                   5    
HELIX   10 AB1 ARG G   87  THR G   91  5                                   5    
HELIX   11 AB2 ILE H   28  TYR H   32  5                                   5    
HELIX   12 AB3 ARG H   87  THR H   91  5                                   5    
HELIX   13 AB4 ILE I   28  TYR I   32  5                                   5    
HELIX   14 AB5 ARG I   87  THR I   91  5                                   5    
HELIX   15 AB6 ARG J  138  LEU J  142  5                                   5    
HELIX   16 AB7 GLU J  146  GLN J  149  5                                   4    
HELIX   17 AB8 ARG K  138  LEU K  142  5                                   5    
HELIX   18 AB9 GLU K  146  GLN K  149  5                                   4    
HELIX   19 AC1 ARG L  138  LEU L  142  5                                   5    
HELIX   20 AC2 GLU L  146  GLN L  149  5                                   4    
HELIX   21 AC3 GLU M   79  PHE M   83  5                                   5    
HELIX   22 AC4 GLU O   79  PHE O   83  5                                   5    
HELIX   23 AC5 ILE P   28  TYR P   32  5                                   5    
HELIX   24 AC6 ARG P   87  THR P   91  5                                   5    
HELIX   25 AC7 ILE Q   28  TYR Q   32  5                                   5    
HELIX   26 AC8 ARG Q   87  THR Q   91  5                                   5    
HELIX   27 AC9 ILE R   28  TYR R   32  5                                   5    
HELIX   28 AD1 ARG R   87  THR R   91  5                                   5    
SHEET    1 AA1 5 TRP A  28  LEU A  29  0                                        
SHEET    2 AA1 5 VAL A  13  ALA A  18 -1  N  VAL A  17   O  LEU A  29           
SHEET    3 AA1 5 TYR A 151  ALA A 156 -1  O  PHE A 152   N  VAL A  16           
SHEET    4 AA1 5 GLY A  54  GLN A  67 -1  N  TYR A  59   O  GLY A 153           
SHEET    5 AA1 5 PRO A 113  LEU A 126 -1  O  GLY A 122   N  ILE A  58           
SHEET    1 AA2 6 LEU A  36  ALA A  38  0                                        
SHEET    2 AA2 6 VAL A  13  ALA A  18 -1  N  HIS A  15   O  LEU A  36           
SHEET    3 AA2 6 TYR A 151  ALA A 156 -1  O  PHE A 152   N  VAL A  16           
SHEET    4 AA2 6 GLY A  54  GLN A  67 -1  N  TYR A  59   O  GLY A 153           
SHEET    5 AA2 6 ALA I 103  ALA I 104 -1  O  ALA I 103   N  GLN A  67           
SHEET    6 AA2 6 TYR I 108  TYR I 109 -1  O  TYR I 108   N  ALA I 104           
SHEET    1 AA3 5 GLU A  42  ARG A  44  0                                        
SHEET    2 AA3 5 GLN A  47  VAL A  49 -1  O  VAL A  49   N  GLU A  42           
SHEET    3 AA3 5 ARG A 131  ILE A 136 -1  O  LEU A 132   N  LEU A  48           
SHEET    4 AA3 5 LEU A  76  ILE A  83 -1  N  THR A  79   O  GLU A 135           
SHEET    5 AA3 5 VAL A  91  LYS A  98 -1  O  LEU A  93   N  ILE A  80           
SHEET    1 AA4 5 TRP B  28  LEU B  29  0                                        
SHEET    2 AA4 5 VAL B  13  ALA B  18 -1  N  VAL B  17   O  LEU B  29           
SHEET    3 AA4 5 TYR B 151  ALA B 156 -1  O  PHE B 152   N  VAL B  16           
SHEET    4 AA4 5 GLY B  54  GLN B  67 -1  N  TYR B  59   O  GLY B 153           
SHEET    5 AA4 5 PRO B 113  LEU B 126 -1  O  GLY B 122   N  ILE B  58           
SHEET    1 AA5 6 LEU B  36  ALA B  38  0                                        
SHEET    2 AA5 6 VAL B  13  ALA B  18 -1  N  HIS B  15   O  LEU B  36           
SHEET    3 AA5 6 TYR B 151  ALA B 156 -1  O  PHE B 152   N  VAL B  16           
SHEET    4 AA5 6 GLY B  54  GLN B  67 -1  N  TYR B  59   O  GLY B 153           
SHEET    5 AA5 6 ALA G 103  ALA G 104 -1  O  ALA G 103   N  GLN B  67           
SHEET    6 AA5 6 TYR G 108  TYR G 109 -1  O  TYR G 108   N  ALA G 104           
SHEET    1 AA6 5 GLU B  42  ARG B  44  0                                        
SHEET    2 AA6 5 GLN B  47  VAL B  49 -1  O  VAL B  49   N  GLU B  42           
SHEET    3 AA6 5 ARG B 131  ILE B 136 -1  O  LEU B 132   N  LEU B  48           
SHEET    4 AA6 5 LEU B  76  ILE B  83 -1  N  THR B  79   O  GLU B 135           
SHEET    5 AA6 5 VAL B  91  LYS B  98 -1  O  LEU B  93   N  ILE B  80           
SHEET    1 AA7 5 TRP C  28  LEU C  29  0                                        
SHEET    2 AA7 5 VAL C  13  ALA C  18 -1  N  VAL C  17   O  LEU C  29           
SHEET    3 AA7 5 TYR C 151  THR C 158 -1  O  PHE C 152   N  VAL C  16           
SHEET    4 AA7 5 GLY C  54  GLN C  67 -1  N  LEU C  55   O  LEU C 157           
SHEET    5 AA7 5 PRO C 113  LEU C 126 -1  O  GLY C 122   N  ILE C  58           
SHEET    1 AA8 6 LEU C  36  ALA C  38  0                                        
SHEET    2 AA8 6 VAL C  13  ALA C  18 -1  N  HIS C  15   O  LEU C  36           
SHEET    3 AA8 6 TYR C 151  THR C 158 -1  O  PHE C 152   N  VAL C  16           
SHEET    4 AA8 6 GLY C  54  GLN C  67 -1  N  LEU C  55   O  LEU C 157           
SHEET    5 AA8 6 ALA H 103  ALA H 104 -1  O  ALA H 103   N  GLN C  67           
SHEET    6 AA8 6 TYR H 108  TYR H 109 -1  O  TYR H 108   N  ALA H 104           
SHEET    1 AA9 5 GLU C  42  ARG C  44  0                                        
SHEET    2 AA9 5 GLN C  47  VAL C  49 -1  O  VAL C  49   N  GLU C  42           
SHEET    3 AA9 5 ARG C 131  ILE C 136 -1  O  LEU C 132   N  LEU C  48           
SHEET    4 AA9 5 VAL C  74  ILE C  83 -1  N  THR C  79   O  GLU C 135           
SHEET    5 AA9 5 VAL C  91  CYS C 101 -1  O  LYS C  98   N  LEU C  76           
SHEET    1 AB1 4 LEU D   4  SER D   7  0                                        
SHEET    2 AB1 4 ALA D  19  ALA D  25 -1  O  ARG D  24   N  THR D   5           
SHEET    3 AB1 4 ASP D  70  ILE D  75 -1  O  LEU D  73   N  LEU D  21           
SHEET    4 AB1 4 PHE D  62  SER D  67 -1  N  SER D  63   O  THR D  74           
SHEET    1 AB2 6 THR D  10  SER D  12  0                                        
SHEET    2 AB2 6 THR D 103  ASP D 106  1  O  LYS D 104   N  LEU D  11           
SHEET    3 AB2 6 VAL D  85  GLN D  90 -1  N  TYR D  86   O  THR D 103           
SHEET    4 AB2 6 LEU D  33  GLN D  38 -1  N  TYR D  36   O  TYR D  87           
SHEET    5 AB2 6 ARG D  45  TYR D  49 -1  O  LEU D  47   N  TRP D  35           
SHEET    6 AB2 6 ASN D  53  ARG D  54 -1  O  ASN D  53   N  TYR D  49           
SHEET    1 AB3 4 LEU E   4  SER E   7  0                                        
SHEET    2 AB3 4 ALA E  19  ALA E  25 -1  O  SER E  22   N  SER E   7           
SHEET    3 AB3 4 ASP E  70  ILE E  75 -1  O  LEU E  73   N  LEU E  21           
SHEET    4 AB3 4 PHE E  62  SER E  67 -1  N  SER E  63   O  THR E  74           
SHEET    1 AB4 6 THR E  10  SER E  12  0                                        
SHEET    2 AB4 6 THR E 103  ASP E 106  1  O  LYS E 104   N  LEU E  11           
SHEET    3 AB4 6 VAL E  85  GLN E  90 -1  N  TYR E  86   O  THR E 103           
SHEET    4 AB4 6 LEU E  33  GLN E  38 -1  N  TYR E  36   O  TYR E  87           
SHEET    5 AB4 6 ARG E  45  TYR E  49 -1  O  ARG E  45   N  GLN E  37           
SHEET    6 AB4 6 ASN E  53  ARG E  54 -1  O  ASN E  53   N  TYR E  49           
SHEET    1 AB5 4 LEU F   4  SER F   7  0                                        
SHEET    2 AB5 4 ALA F  19  ALA F  25 -1  O  ARG F  24   N  THR F   5           
SHEET    3 AB5 4 ASP F  70  ILE F  75 -1  O  LEU F  73   N  LEU F  21           
SHEET    4 AB5 4 PHE F  62  SER F  67 -1  N  SER F  63   O  THR F  74           
SHEET    1 AB6 6 THR F  10  SER F  12  0                                        
SHEET    2 AB6 6 THR F 103  ASP F 106  1  O  LYS F 104   N  LEU F  11           
SHEET    3 AB6 6 VAL F  85  GLN F  90 -1  N  TYR F  86   O  THR F 103           
SHEET    4 AB6 6 LEU F  33  GLN F  38 -1  N  TYR F  36   O  TYR F  87           
SHEET    5 AB6 6 ARG F  45  TYR F  49 -1  O  ARG F  45   N  GLN F  37           
SHEET    6 AB6 6 ASN F  53  ARG F  54 -1  O  ASN F  53   N  TYR F  49           
SHEET    1 AB7 4 GLN G   3  SER G   7  0                                        
SHEET    2 AB7 4 LEU G  18  SER G  25 -1  O  ALA G  23   N  VAL G   5           
SHEET    3 AB7 4 THR G  78  MET G  83 -1  O  MET G  83   N  LEU G  18           
SHEET    4 AB7 4 PHE G  68  ASP G  73 -1  N  ASP G  73   O  THR G  78           
SHEET    1 AB8 6 VAL G  11  VAL G  12  0                                        
SHEET    2 AB8 6 THR G 120  VAL G 124  1  O  THR G 123   N  VAL G  12           
SHEET    3 AB8 6 ALA G  92  ASP G  99 -1  N  TYR G  94   O  THR G 120           
SHEET    4 AB8 6 ALA G  33  GLN G  39 -1  N  VAL G  37   O  TYR G  95           
SHEET    5 AB8 6 LEU G  45  MET G  51 -1  O  VAL G  48   N  TRP G  36           
SHEET    6 AB8 6 LYS G  58  TYR G  60 -1  O  LYS G  59   N  PHE G  50           
SHEET    1 AB9 4 GLN H   3  SER H   7  0                                        
SHEET    2 AB9 4 LEU H  18  SER H  25 -1  O  SER H  21   N  SER H   7           
SHEET    3 AB9 4 THR H  78  MET H  83 -1  O  MET H  83   N  LEU H  18           
SHEET    4 AB9 4 PHE H  68  ASP H  73 -1  N  SER H  71   O  TYR H  80           
SHEET    1 AC1 6 GLY H  10  VAL H  12  0                                        
SHEET    2 AC1 6 THR H 120  VAL H 124  1  O  THR H 123   N  GLY H  10           
SHEET    3 AC1 6 ALA H  92  ASP H  99 -1  N  TYR H  94   O  THR H 120           
SHEET    4 AC1 6 ALA H  33  GLN H  39 -1  N  VAL H  37   O  TYR H  95           
SHEET    5 AC1 6 LEU H  45  MET H  51 -1  O  GLU H  46   N  ARG H  38           
SHEET    6 AC1 6 LYS H  58  TYR H  60 -1  O  LYS H  59   N  PHE H  50           
SHEET    1 AC2 4 GLN I   3  SER I   7  0                                        
SHEET    2 AC2 4 LEU I  18  SER I  25 -1  O  SER I  21   N  SER I   7           
SHEET    3 AC2 4 THR I  78  MET I  83 -1  O  LEU I  81   N  LEU I  20           
SHEET    4 AC2 4 PHE I  68  ASP I  73 -1  N  SER I  71   O  TYR I  80           
SHEET    1 AC3 6 GLY I  10  VAL I  12  0                                        
SHEET    2 AC3 6 THR I 120  VAL I 124  1  O  THR I 123   N  GLY I  10           
SHEET    3 AC3 6 ALA I  92  ASP I  99 -1  N  TYR I  94   O  THR I 120           
SHEET    4 AC3 6 ALA I  33  GLN I  39 -1  N  VAL I  37   O  TYR I  95           
SHEET    5 AC3 6 LEU I  45  MET I  51 -1  O  VAL I  48   N  TRP I  36           
SHEET    6 AC3 6 LYS I  58  TYR I  60 -1  O  LYS I  59   N  PHE I  50           
SHEET    1 AC4 5 TRP J  28  LEU J  29  0                                        
SHEET    2 AC4 5 VAL J  13  ALA J  18 -1  N  VAL J  17   O  LEU J  29           
SHEET    3 AC4 5 TYR J 151  ALA J 156 -1  O  PHE J 152   N  VAL J  16           
SHEET    4 AC4 5 GLY J  54  GLN J  67 -1  N  TYR J  59   O  GLY J 153           
SHEET    5 AC4 5 PRO J 113  LEU J 126 -1  O  GLY J 122   N  ILE J  58           
SHEET    1 AC5 6 LEU J  36  ALA J  38  0                                        
SHEET    2 AC5 6 VAL J  13  ALA J  18 -1  N  HIS J  15   O  LEU J  36           
SHEET    3 AC5 6 TYR J 151  ALA J 156 -1  O  PHE J 152   N  VAL J  16           
SHEET    4 AC5 6 GLY J  54  GLN J  67 -1  N  TYR J  59   O  GLY J 153           
SHEET    5 AC5 6 ALA R 103  ALA R 104 -1  O  ALA R 103   N  GLN J  67           
SHEET    6 AC5 6 TYR R 108  TYR R 109 -1  O  TYR R 108   N  ALA R 104           
SHEET    1 AC6 5 GLU J  42  ARG J  44  0                                        
SHEET    2 AC6 5 GLN J  47  VAL J  49 -1  O  VAL J  49   N  GLU J  42           
SHEET    3 AC6 5 ARG J 131  ILE J 136 -1  O  LEU J 132   N  LEU J  48           
SHEET    4 AC6 5 LEU J  76  ILE J  83 -1  N  THR J  79   O  GLU J 135           
SHEET    5 AC6 5 LYS J  90  LYS J  98 -1  O  LEU J  93   N  ILE J  80           
SHEET    1 AC7 5 TRP K  28  LEU K  29  0                                        
SHEET    2 AC7 5 VAL K  13  ALA K  18 -1  N  VAL K  17   O  LEU K  29           
SHEET    3 AC7 5 TYR K 151  ALA K 156 -1  O  PHE K 152   N  VAL K  16           
SHEET    4 AC7 5 GLY K  54  GLN K  67 -1  N  TYR K  59   O  GLY K 153           
SHEET    5 AC7 5 PRO K 113  LEU K 126 -1  O  GLY K 122   N  ILE K  58           
SHEET    1 AC8 6 LEU K  36  ALA K  38  0                                        
SHEET    2 AC8 6 VAL K  13  ALA K  18 -1  N  HIS K  15   O  LEU K  36           
SHEET    3 AC8 6 TYR K 151  ALA K 156 -1  O  PHE K 152   N  VAL K  16           
SHEET    4 AC8 6 GLY K  54  GLN K  67 -1  N  TYR K  59   O  GLY K 153           
SHEET    5 AC8 6 ALA P 103  ALA P 104 -1  O  ALA P 103   N  GLN K  67           
SHEET    6 AC8 6 TYR P 108  TYR P 109 -1  O  TYR P 108   N  ALA P 104           
SHEET    1 AC9 5 GLU K  42  ARG K  44  0                                        
SHEET    2 AC9 5 GLN K  47  VAL K  49 -1  O  VAL K  49   N  GLU K  42           
SHEET    3 AC9 5 ARG K 131  ILE K 136 -1  O  LEU K 132   N  LEU K  48           
SHEET    4 AC9 5 VAL K  74  ILE K  83 -1  N  THR K  79   O  GLU K 135           
SHEET    5 AC9 5 LYS K  90  CYS K 101 -1  O  VAL K  91   N  ARG K  82           
SHEET    1 AD1 5 TRP L  28  LEU L  29  0                                        
SHEET    2 AD1 5 VAL L  13  ALA L  18 -1  N  VAL L  17   O  LEU L  29           
SHEET    3 AD1 5 TYR L 151  ALA L 156 -1  O  PHE L 152   N  VAL L  16           
SHEET    4 AD1 5 GLY L  54  GLN L  67 -1  N  TYR L  59   O  GLY L 153           
SHEET    5 AD1 5 PRO L 113  LEU L 126 -1  O  GLY L 122   N  ILE L  58           
SHEET    1 AD2 6 LEU L  36  ALA L  38  0                                        
SHEET    2 AD2 6 VAL L  13  ALA L  18 -1  N  HIS L  15   O  LEU L  36           
SHEET    3 AD2 6 TYR L 151  ALA L 156 -1  O  PHE L 152   N  VAL L  16           
SHEET    4 AD2 6 GLY L  54  GLN L  67 -1  N  TYR L  59   O  GLY L 153           
SHEET    5 AD2 6 ALA Q 103  ALA Q 104 -1  O  ALA Q 103   N  GLN L  67           
SHEET    6 AD2 6 TYR Q 108  TYR Q 109 -1  O  TYR Q 108   N  ALA Q 104           
SHEET    1 AD3 5 GLU L  42  ARG L  44  0                                        
SHEET    2 AD3 5 GLN L  47  VAL L  49 -1  O  VAL L  49   N  GLU L  42           
SHEET    3 AD3 5 ARG L 131  ILE L 136 -1  O  LEU L 132   N  LEU L  48           
SHEET    4 AD3 5 VAL L  74  ILE L  83 -1  N  THR L  79   O  GLU L 135           
SHEET    5 AD3 5 LYS L  90  CYS L 101 -1  O  LYS L  98   N  LEU L  76           
SHEET    1 AD4 4 LEU M   4  SER M   7  0                                        
SHEET    2 AD4 4 ALA M  19  ALA M  25 -1  O  ARG M  24   N  THR M   5           
SHEET    3 AD4 4 ASP M  70  ILE M  75 -1  O  LEU M  73   N  LEU M  21           
SHEET    4 AD4 4 PHE M  62  SER M  67 -1  N  SER M  63   O  THR M  74           
SHEET    1 AD5 6 THR M  10  LEU M  13  0                                        
SHEET    2 AD5 6 THR M 103  ILE M 107  1  O  ASP M 106   N  LEU M  11           
SHEET    3 AD5 6 VAL M  85  GLN M  90 -1  N  TYR M  86   O  THR M 103           
SHEET    4 AD5 6 LEU M  33  GLN M  38 -1  N  TYR M  36   O  TYR M  87           
SHEET    5 AD5 6 ARG M  45  TYR M  49 -1  O  LEU M  47   N  TRP M  35           
SHEET    6 AD5 6 ASN M  53  ARG M  54 -1  O  ASN M  53   N  TYR M  49           
SHEET    1 AD6 4 LEU N   4  SER N   7  0                                        
SHEET    2 AD6 4 ALA N  19  ALA N  25 -1  O  ARG N  24   N  THR N   5           
SHEET    3 AD6 4 ASP N  70  ILE N  75 -1  O  LEU N  73   N  LEU N  21           
SHEET    4 AD6 4 PHE N  62  SER N  67 -1  N  SER N  63   O  THR N  74           
SHEET    1 AD7 6 THR N  10  SER N  12  0                                        
SHEET    2 AD7 6 THR N 103  ASP N 106  1  O  LYS N 104   N  LEU N  11           
SHEET    3 AD7 6 VAL N  85  GLN N  90 -1  N  TYR N  86   O  THR N 103           
SHEET    4 AD7 6 LEU N  33  GLN N  38 -1  N  TYR N  36   O  TYR N  87           
SHEET    5 AD7 6 ARG N  45  TYR N  49 -1  O  ARG N  45   N  GLN N  37           
SHEET    6 AD7 6 ASN N  53  ARG N  54 -1  O  ASN N  53   N  TYR N  49           
SHEET    1 AD8 4 LEU O   4  SER O   7  0                                        
SHEET    2 AD8 4 ALA O  19  ALA O  25 -1  O  ARG O  24   N  THR O   5           
SHEET    3 AD8 4 ASP O  70  ILE O  75 -1  O  LEU O  73   N  LEU O  21           
SHEET    4 AD8 4 PHE O  62  SER O  67 -1  N  SER O  63   O  THR O  74           
SHEET    1 AD9 6 THR O  10  SER O  12  0                                        
SHEET    2 AD9 6 THR O 103  ASP O 106  1  O  LYS O 104   N  LEU O  11           
SHEET    3 AD9 6 VAL O  85  GLN O  90 -1  N  TYR O  86   O  THR O 103           
SHEET    4 AD9 6 LEU O  33  GLN O  38 -1  N  TYR O  36   O  TYR O  87           
SHEET    5 AD9 6 ARG O  45  TYR O  49 -1  O  ARG O  45   N  GLN O  37           
SHEET    6 AD9 6 ASN O  53  ARG O  54 -1  O  ASN O  53   N  TYR O  49           
SHEET    1 AE1 4 GLN P   3  SER P   7  0                                        
SHEET    2 AE1 4 LEU P  18  SER P  25 -1  O  SER P  25   N  GLN P   3           
SHEET    3 AE1 4 THR P  78  MET P  83 -1  O  MET P  83   N  LEU P  18           
SHEET    4 AE1 4 PHE P  68  ASP P  73 -1  N  SER P  71   O  TYR P  80           
SHEET    1 AE2 6 GLY P  10  VAL P  12  0                                        
SHEET    2 AE2 6 THR P 120  VAL P 124  1  O  THR P 123   N  VAL P  12           
SHEET    3 AE2 6 ALA P  92  ASP P  99 -1  N  TYR P  94   O  THR P 120           
SHEET    4 AE2 6 ALA P  33  GLN P  39 -1  N  VAL P  37   O  TYR P  95           
SHEET    5 AE2 6 LEU P  45  MET P  51 -1  O  VAL P  48   N  TRP P  36           
SHEET    6 AE2 6 LYS P  58  TYR P  60 -1  O  LYS P  59   N  PHE P  50           
SHEET    1 AE3 4 GLN Q   3  SER Q   7  0                                        
SHEET    2 AE3 4 LEU Q  18  SER Q  25 -1  O  SER Q  21   N  SER Q   7           
SHEET    3 AE3 4 THR Q  78  MET Q  83 -1  O  MET Q  83   N  LEU Q  18           
SHEET    4 AE3 4 PHE Q  68  ASP Q  73 -1  N  ASP Q  73   O  THR Q  78           
SHEET    1 AE4 6 GLY Q  10  VAL Q  11  0                                        
SHEET    2 AE4 6 THR Q 120  THR Q 123  1  O  THR Q 123   N  GLY Q  10           
SHEET    3 AE4 6 ALA Q  92  ASP Q  99 -1  N  TYR Q  94   O  THR Q 120           
SHEET    4 AE4 6 ALA Q  33  GLN Q  39 -1  N  VAL Q  37   O  TYR Q  95           
SHEET    5 AE4 6 LEU Q  45  MET Q  51 -1  O  VAL Q  48   N  TRP Q  36           
SHEET    6 AE4 6 LYS Q  58  TYR Q  60 -1  O  LYS Q  59   N  PHE Q  50           
SHEET    1 AE5 4 GLN R   3  SER R   7  0                                        
SHEET    2 AE5 4 LEU R  18  SER R  25 -1  O  SER R  21   N  SER R   7           
SHEET    3 AE5 4 THR R  78  MET R  83 -1  O  MET R  83   N  LEU R  18           
SHEET    4 AE5 4 PHE R  68  ASP R  73 -1  N  SER R  71   O  TYR R  80           
SHEET    1 AE6 6 GLY R  10  VAL R  12  0                                        
SHEET    2 AE6 6 THR R 120  VAL R 124  1  O  THR R 123   N  VAL R  12           
SHEET    3 AE6 6 ALA R  92  ASP R  99 -1  N  ALA R  92   O  VAL R 122           
SHEET    4 AE6 6 ALA R  33  GLN R  39 -1  N  VAL R  37   O  TYR R  95           
SHEET    5 AE6 6 LEU R  45  MET R  51 -1  O  VAL R  48   N  TRP R  36           
SHEET    6 AE6 6 LYS R  58  TYR R  60 -1  O  LYS R  59   N  PHE R  50           
SSBOND   1 CYS A   69    CYS A  101                          1555   1555  2.03  
SSBOND   2 CYS B   69    CYS B  101                          1555   1555  2.04  
SSBOND   3 CYS C   69    CYS C  101                          1555   1555  2.05  
SSBOND   4 CYS D   23    CYS D   88                          1555   1555  2.04  
SSBOND   5 CYS E   23    CYS E   88                          1555   1555  2.04  
SSBOND   6 CYS F   23    CYS F   88                          1555   1555  2.04  
SSBOND   7 CYS G   22    CYS G   96                          1555   1555  2.04  
SSBOND   8 CYS H   22    CYS H   96                          1555   1555  2.05  
SSBOND   9 CYS I   22    CYS I   96                          1555   1555  2.03  
SSBOND  10 CYS J   69    CYS J  101                          1555   1555  2.03  
SSBOND  11 CYS K   69    CYS K  101                          1555   1555  2.04  
SSBOND  12 CYS L   69    CYS L  101                          1555   1555  2.05  
SSBOND  13 CYS M   23    CYS M   88                          1555   1555  2.04  
SSBOND  14 CYS N   23    CYS N   88                          1555   1555  2.04  
SSBOND  15 CYS O   23    CYS O   88                          1555   1555  2.04  
SSBOND  16 CYS P   22    CYS P   96                          1555   1555  2.03  
SSBOND  17 CYS Q   22    CYS Q   96                          1555   1555  2.04  
SSBOND  18 CYS R   22    CYS R   96                          1555   1555  2.04  
CISPEP   1 SER D    7    PRO D    8          0        -0.25                     
CISPEP   2 TRP D   94    PRO D   95          0        -8.59                     
CISPEP   3 SER E    7    PRO E    8          0         0.30                     
CISPEP   4 TRP E   94    PRO E   95          0        -7.84                     
CISPEP   5 SER F    7    PRO F    8          0        -0.02                     
CISPEP   6 TRP F   94    PRO F   95          0        -8.35                     
CISPEP   7 SER M    7    PRO M    8          0        -0.43                     
CISPEP   8 TRP M   94    PRO M   95          0        -8.00                     
CISPEP   9 SER N    7    PRO N    8          0         0.92                     
CISPEP  10 TRP N   94    PRO N   95          0        -8.31                     
CISPEP  11 SER O    7    PRO O    8          0         0.75                     
CISPEP  12 TRP O   94    PRO O   95          0        -8.94                     
CRYST1  133.640   85.300  135.960  90.00 101.61  90.00 P 1 21 1     12          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.007483  0.000000  0.001537        0.00000                         
SCALE2      0.000000  0.011723  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.007509        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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