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Database: PDB
Entry: 5YTU
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HEADER    OXIDOREDUCTASE                          20-NOV-17   5YTU              
TITLE     STRUCTURE OF HUMAN SOD1 COMPLEXED WITH ISOPROTERANOL IN C2221 SPACE   
TITLE    2 GROUP                                                                
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: SUPEROXIDE DISMUTASE [CU-ZN];                              
COMPND   3 CHAIN: A, H, B, C, D, E, F, G, I, J;                                 
COMPND   4 SYNONYM: SUPEROXIDE DISMUTASE 1,HSOD1;                               
COMPND   5 EC: 1.15.1.1;                                                        
COMPND   6 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: SOD1;                                                          
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21 STAR;                                 
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PETM11                                    
KEYWDS    ISOPROTERANOL, COMPLEX, DIMER STABILIZER, OXIDOREDUCTASE              
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    R.MANJULA,B.PADMANABHAN                                               
REVDAT   1   21-NOV-18 5YTU    0                                                
JRNL        AUTH   R.MANJULA,G.S.A.WRIGHT,R.W.STRANGE,B.PADMANABHAN             
JRNL        TITL   ASSESSMENT OF LIGAND BINDING AT A SITE RELEVANT TO SOD1      
JRNL        TITL 2 OXIDATION AND AGGREGATION                                    
JRNL        REF    FEBS LETT.                    V. 592  1725 2018              
JRNL        REFN                   ISSN 1873-3468                               
JRNL        PMID   29679384                                                     
JRNL        DOI    10.1002/1873-3468.13055                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    1.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.7.0029                                      
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,              
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN                             
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.90                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 20.00                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 96.9                           
REMARK   3   NUMBER OF REFLECTIONS             : 174966                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.181                           
REMARK   3   R VALUE            (WORKING SET) : 0.179                           
REMARK   3   FREE R VALUE                     : 0.221                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 9181                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 1.90                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 1.95                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 10409                        
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 78.98                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2820                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 528                          
REMARK   3   BIN FREE R VALUE                    : 0.3280                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 10859                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 54                                      
REMARK   3   SOLVENT ATOMS            : 1631                                    
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 36.72                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 1.26000                                              
REMARK   3    B22 (A**2) : 0.43000                                              
REMARK   3    B33 (A**2) : -1.69000                                             
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): 0.112         
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.117         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.081         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 2.774         
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.965                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.945                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 11273 ; 0.014 ; 0.019       
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 15259 ; 1.536 ; 1.946       
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  1540 ; 6.537 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   470 ;41.089 ;25.681       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  1796 ;13.996 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    37 ;16.179 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  1690 ; 0.110 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  8660 ; 0.007 ; 0.021       
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL                              
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : NULL                                                 
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 5YTU COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 21-NOV-17.                  
REMARK 100 THE DEPOSITION ID IS D_1300005909.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 22-NOV-15                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : ESRF                               
REMARK 200  BEAMLINE                       : BM14                               
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.95372                            
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 225 MM CCD               
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-3000                           
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 184956                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.900                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 95.9                               
REMARK 200  DATA REDUNDANCY                : 5.400                              
REMARK 200  R MERGE                    (I) : 0.07800                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 20.4700                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.90                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.93                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 62.1                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.10                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.74000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 1.000                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: MOLREP                                                
REMARK 200 STARTING MODEL: 4A7S                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 61.30                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.18                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: SODIUM CITRATE, PH 6.0, VAPOR            
REMARK 280  DIFFUSION, HANGING DROP, TEMPERATURE 300K                           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 2 2 21                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,-Y,Z+1/2                                             
REMARK 290       3555   -X,Y,-Z+1/2                                             
REMARK 290       4555   X,-Y,-Z                                                 
REMARK 290       5555   X+1/2,Y+1/2,Z                                           
REMARK 290       6555   -X+1/2,-Y+1/2,Z+1/2                                     
REMARK 290       7555   -X+1/2,Y+1/2,-Z+1/2                                     
REMARK 290       8555   X+1/2,-Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       72.38550            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       72.38550            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000       82.26050            
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000      101.89550            
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   6 -1.000000  0.000000  0.000000       82.26050            
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000      101.89550            
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       72.38550            
REMARK 290   SMTRY1   7 -1.000000  0.000000  0.000000       82.26050            
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000      101.89550            
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       72.38550            
REMARK 290   SMTRY1   8  1.000000  0.000000  0.000000       82.26050            
REMARK 290   SMTRY2   8  0.000000 -1.000000  0.000000      101.89550            
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5                                           
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 2190 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 14290 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -13.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, H                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 1730 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 14090 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -12.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, C                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 1630 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 13810 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -14.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, E                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 4                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 1430 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 12690 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -12.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: F, G                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 5                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 1430 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 13830 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -11.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: I, J                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 375                                                                      
REMARK 375 SPECIAL POSITION                                                     
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS            
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL          
REMARK 375 POSITIONS.                                                           
REMARK 375                                                                      
REMARK 375 ATOM RES CSSEQI                                                      
REMARK 375      HOH F 474  LIES ON A SPECIAL POSITION.                          
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -26                                                      
REMARK 465     LYS A   -25                                                      
REMARK 465     HIS A   -24                                                      
REMARK 465     HIS A   -23                                                      
REMARK 465     HIS A   -22                                                      
REMARK 465     HIS A   -21                                                      
REMARK 465     HIS A   -20                                                      
REMARK 465     HIS A   -19                                                      
REMARK 465     PRO A   -18                                                      
REMARK 465     MET A   -17                                                      
REMARK 465     SER A   -16                                                      
REMARK 465     ASP A   -15                                                      
REMARK 465     TYR A   -14                                                      
REMARK 465     ASP A   -13                                                      
REMARK 465     ILE A   -12                                                      
REMARK 465     PRO A   -11                                                      
REMARK 465     THR A   -10                                                      
REMARK 465     THR A    -9                                                      
REMARK 465     GLU A    -8                                                      
REMARK 465     ASN A    -7                                                      
REMARK 465     LEU A    -6                                                      
REMARK 465     TYR A    -5                                                      
REMARK 465     PHE A    -4                                                      
REMARK 465     GLN A    -3                                                      
REMARK 465     GLY A    -2                                                      
REMARK 465     ALA A    -1                                                      
REMARK 465     MET H   -26                                                      
REMARK 465     LYS H   -25                                                      
REMARK 465     HIS H   -24                                                      
REMARK 465     HIS H   -23                                                      
REMARK 465     HIS H   -22                                                      
REMARK 465     HIS H   -21                                                      
REMARK 465     HIS H   -20                                                      
REMARK 465     HIS H   -19                                                      
REMARK 465     PRO H   -18                                                      
REMARK 465     MET H   -17                                                      
REMARK 465     SER H   -16                                                      
REMARK 465     ASP H   -15                                                      
REMARK 465     TYR H   -14                                                      
REMARK 465     ASP H   -13                                                      
REMARK 465     ILE H   -12                                                      
REMARK 465     PRO H   -11                                                      
REMARK 465     THR H   -10                                                      
REMARK 465     THR H    -9                                                      
REMARK 465     GLU H    -8                                                      
REMARK 465     ASN H    -7                                                      
REMARK 465     LEU H    -6                                                      
REMARK 465     TYR H    -5                                                      
REMARK 465     PHE H    -4                                                      
REMARK 465     GLN H    -3                                                      
REMARK 465     GLY H    -2                                                      
REMARK 465     ALA H    -1                                                      
REMARK 465     MET B   -26                                                      
REMARK 465     LYS B   -25                                                      
REMARK 465     HIS B   -24                                                      
REMARK 465     HIS B   -23                                                      
REMARK 465     HIS B   -22                                                      
REMARK 465     HIS B   -21                                                      
REMARK 465     HIS B   -20                                                      
REMARK 465     HIS B   -19                                                      
REMARK 465     PRO B   -18                                                      
REMARK 465     MET B   -17                                                      
REMARK 465     SER B   -16                                                      
REMARK 465     ASP B   -15                                                      
REMARK 465     TYR B   -14                                                      
REMARK 465     ASP B   -13                                                      
REMARK 465     ILE B   -12                                                      
REMARK 465     PRO B   -11                                                      
REMARK 465     THR B   -10                                                      
REMARK 465     THR B    -9                                                      
REMARK 465     GLU B    -8                                                      
REMARK 465     ASN B    -7                                                      
REMARK 465     LEU B    -6                                                      
REMARK 465     TYR B    -5                                                      
REMARK 465     PHE B    -4                                                      
REMARK 465     GLN B    -3                                                      
REMARK 465     GLY B    -2                                                      
REMARK 465     ALA B    -1                                                      
REMARK 465     MET C   -26                                                      
REMARK 465     LYS C   -25                                                      
REMARK 465     HIS C   -24                                                      
REMARK 465     HIS C   -23                                                      
REMARK 465     HIS C   -22                                                      
REMARK 465     HIS C   -21                                                      
REMARK 465     HIS C   -20                                                      
REMARK 465     HIS C   -19                                                      
REMARK 465     PRO C   -18                                                      
REMARK 465     MET C   -17                                                      
REMARK 465     SER C   -16                                                      
REMARK 465     ASP C   -15                                                      
REMARK 465     TYR C   -14                                                      
REMARK 465     ASP C   -13                                                      
REMARK 465     ILE C   -12                                                      
REMARK 465     PRO C   -11                                                      
REMARK 465     THR C   -10                                                      
REMARK 465     THR C    -9                                                      
REMARK 465     GLU C    -8                                                      
REMARK 465     ASN C    -7                                                      
REMARK 465     LEU C    -6                                                      
REMARK 465     TYR C    -5                                                      
REMARK 465     PHE C    -4                                                      
REMARK 465     GLN C    -3                                                      
REMARK 465     GLY C    -2                                                      
REMARK 465     ALA C    -1                                                      
REMARK 465     MET D   -26                                                      
REMARK 465     LYS D   -25                                                      
REMARK 465     HIS D   -24                                                      
REMARK 465     HIS D   -23                                                      
REMARK 465     HIS D   -22                                                      
REMARK 465     HIS D   -21                                                      
REMARK 465     HIS D   -20                                                      
REMARK 465     HIS D   -19                                                      
REMARK 465     PRO D   -18                                                      
REMARK 465     MET D   -17                                                      
REMARK 465     SER D   -16                                                      
REMARK 465     ASP D   -15                                                      
REMARK 465     TYR D   -14                                                      
REMARK 465     ASP D   -13                                                      
REMARK 465     ILE D   -12                                                      
REMARK 465     PRO D   -11                                                      
REMARK 465     THR D   -10                                                      
REMARK 465     THR D    -9                                                      
REMARK 465     GLU D    -8                                                      
REMARK 465     ASN D    -7                                                      
REMARK 465     LEU D    -6                                                      
REMARK 465     TYR D    -5                                                      
REMARK 465     PHE D    -4                                                      
REMARK 465     GLN D    -3                                                      
REMARK 465     GLY D    -2                                                      
REMARK 465     ALA D    -1                                                      
REMARK 465     MET E   -26                                                      
REMARK 465     LYS E   -25                                                      
REMARK 465     HIS E   -24                                                      
REMARK 465     HIS E   -23                                                      
REMARK 465     HIS E   -22                                                      
REMARK 465     HIS E   -21                                                      
REMARK 465     HIS E   -20                                                      
REMARK 465     HIS E   -19                                                      
REMARK 465     PRO E   -18                                                      
REMARK 465     MET E   -17                                                      
REMARK 465     SER E   -16                                                      
REMARK 465     ASP E   -15                                                      
REMARK 465     TYR E   -14                                                      
REMARK 465     ASP E   -13                                                      
REMARK 465     ILE E   -12                                                      
REMARK 465     PRO E   -11                                                      
REMARK 465     THR E   -10                                                      
REMARK 465     THR E    -9                                                      
REMARK 465     GLU E    -8                                                      
REMARK 465     ASN E    -7                                                      
REMARK 465     LEU E    -6                                                      
REMARK 465     TYR E    -5                                                      
REMARK 465     PHE E    -4                                                      
REMARK 465     GLN E    -3                                                      
REMARK 465     GLY E    -2                                                      
REMARK 465     MET F   -26                                                      
REMARK 465     LYS F   -25                                                      
REMARK 465     HIS F   -24                                                      
REMARK 465     HIS F   -23                                                      
REMARK 465     HIS F   -22                                                      
REMARK 465     HIS F   -21                                                      
REMARK 465     HIS F   -20                                                      
REMARK 465     HIS F   -19                                                      
REMARK 465     PRO F   -18                                                      
REMARK 465     MET F   -17                                                      
REMARK 465     SER F   -16                                                      
REMARK 465     ASP F   -15                                                      
REMARK 465     TYR F   -14                                                      
REMARK 465     ASP F   -13                                                      
REMARK 465     ILE F   -12                                                      
REMARK 465     PRO F   -11                                                      
REMARK 465     THR F   -10                                                      
REMARK 465     THR F    -9                                                      
REMARK 465     GLU F    -8                                                      
REMARK 465     ASN F    -7                                                      
REMARK 465     LEU F    -6                                                      
REMARK 465     TYR F    -5                                                      
REMARK 465     PHE F    -4                                                      
REMARK 465     GLN F    -3                                                      
REMARK 465     GLY F    -2                                                      
REMARK 465     ALA F    -1                                                      
REMARK 465     MET G   -26                                                      
REMARK 465     LYS G   -25                                                      
REMARK 465     HIS G   -24                                                      
REMARK 465     HIS G   -23                                                      
REMARK 465     HIS G   -22                                                      
REMARK 465     HIS G   -21                                                      
REMARK 465     HIS G   -20                                                      
REMARK 465     HIS G   -19                                                      
REMARK 465     PRO G   -18                                                      
REMARK 465     MET G   -17                                                      
REMARK 465     SER G   -16                                                      
REMARK 465     ASP G   -15                                                      
REMARK 465     TYR G   -14                                                      
REMARK 465     ASP G   -13                                                      
REMARK 465     ILE G   -12                                                      
REMARK 465     PRO G   -11                                                      
REMARK 465     THR G   -10                                                      
REMARK 465     THR G    -9                                                      
REMARK 465     GLU G    -8                                                      
REMARK 465     ASN G    -7                                                      
REMARK 465     LEU G    -6                                                      
REMARK 465     TYR G    -5                                                      
REMARK 465     PHE G    -4                                                      
REMARK 465     GLN G    -3                                                      
REMARK 465     GLY G    -2                                                      
REMARK 465     ALA G    -1                                                      
REMARK 465     MET G     0                                                      
REMARK 465     LEU G    67                                                      
REMARK 465     SER G    68                                                      
REMARK 465     ARG G    69                                                      
REMARK 465     LYS G    70                                                      
REMARK 465     HIS G    71                                                      
REMARK 465     GLY G    72                                                      
REMARK 465     GLY G    73                                                      
REMARK 465     PRO G    74                                                      
REMARK 465     LYS G    75                                                      
REMARK 465     ASP G    76                                                      
REMARK 465     GLU G    77                                                      
REMARK 465     GLU G    78                                                      
REMARK 465     LEU G   126                                                      
REMARK 465     GLY G   127                                                      
REMARK 465     LYS G   128                                                      
REMARK 465     GLY G   129                                                      
REMARK 465     GLY G   130                                                      
REMARK 465     ASN G   131                                                      
REMARK 465     GLU G   132                                                      
REMARK 465     GLU G   133                                                      
REMARK 465     SER G   134                                                      
REMARK 465     THR G   135                                                      
REMARK 465     LYS G   136                                                      
REMARK 465     THR G   137                                                      
REMARK 465     GLY G   138                                                      
REMARK 465     ASN G   139                                                      
REMARK 465     ALA G   140                                                      
REMARK 465     GLY G   141                                                      
REMARK 465     MET I   -26                                                      
REMARK 465     LYS I   -25                                                      
REMARK 465     HIS I   -24                                                      
REMARK 465     HIS I   -23                                                      
REMARK 465     HIS I   -22                                                      
REMARK 465     HIS I   -21                                                      
REMARK 465     HIS I   -20                                                      
REMARK 465     HIS I   -19                                                      
REMARK 465     PRO I   -18                                                      
REMARK 465     MET I   -17                                                      
REMARK 465     SER I   -16                                                      
REMARK 465     ASP I   -15                                                      
REMARK 465     TYR I   -14                                                      
REMARK 465     ASP I   -13                                                      
REMARK 465     ILE I   -12                                                      
REMARK 465     PRO I   -11                                                      
REMARK 465     THR I   -10                                                      
REMARK 465     THR I    -9                                                      
REMARK 465     GLU I    -8                                                      
REMARK 465     ASN I    -7                                                      
REMARK 465     LEU I    -6                                                      
REMARK 465     TYR I    -5                                                      
REMARK 465     PHE I    -4                                                      
REMARK 465     GLN I    -3                                                      
REMARK 465     GLY I    -2                                                      
REMARK 465     ALA I    -1                                                      
REMARK 465     MET I     0                                                      
REMARK 465     ALA I     1                                                      
REMARK 465     MET J   -26                                                      
REMARK 465     LYS J   -25                                                      
REMARK 465     HIS J   -24                                                      
REMARK 465     HIS J   -23                                                      
REMARK 465     HIS J   -22                                                      
REMARK 465     HIS J   -21                                                      
REMARK 465     HIS J   -20                                                      
REMARK 465     HIS J   -19                                                      
REMARK 465     PRO J   -18                                                      
REMARK 465     MET J   -17                                                      
REMARK 465     SER J   -16                                                      
REMARK 465     ASP J   -15                                                      
REMARK 465     TYR J   -14                                                      
REMARK 465     ASP J   -13                                                      
REMARK 465     ILE J   -12                                                      
REMARK 465     PRO J   -11                                                      
REMARK 465     THR J   -10                                                      
REMARK 465     THR J    -9                                                      
REMARK 465     GLU J    -8                                                      
REMARK 465     ASN J    -7                                                      
REMARK 465     LEU J    -6                                                      
REMARK 465     TYR J    -5                                                      
REMARK 465     PHE J    -4                                                      
REMARK 465     GLN J    -3                                                      
REMARK 465     GLY J    -2                                                      
REMARK 465     ALA J    -1                                                      
REMARK 465     MET J     0                                                      
REMARK 465     ALA J     1                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     MET B   0    CG   SD   CE                                        
REMARK 470     MET C   0    CG   SD   CE                                        
REMARK 470     MET D   0    CG   SD   CE                                        
REMARK 470     ARG E  69    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E  70    CG   CD   CE   NZ                                   
REMARK 470     LYS E  75    CG   CD   CE   NZ                                   
REMARK 470     GLU E  77    CG   CD   OE1  OE2                                  
REMARK 470     LEU E 126    CG   CD1  CD2                                       
REMARK 470     LYS E 128    CG   CD   CE   NZ                                   
REMARK 470     GLU E 132    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 133    CG   CD   OE1  OE2                                  
REMARK 470     THR E 137    OG1  CG2                                            
REMARK 470     MET F   0    CG   SD   CE                                        
REMARK 470     LYS F  23    CG   CD   CE   NZ                                   
REMARK 470     LYS G  23    CG   CD   CE   NZ                                   
REMARK 470     GLU G  24    CG   CD   OE1  OE2                                  
REMARK 470     ASN G  26    CG   OD1  ND2                                       
REMARK 470     ARG G  79    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I  24    CG   CD   OE1  OE2                                  
REMARK 470     LYS I  30    CG   CD   CE   NZ                                   
REMARK 470     LYS I  36    CG   CD   CE   NZ                                   
REMARK 470     LYS J  23    CG   CD   CE   NZ                                   
REMARK 470     SER J  68    OG                                                  
REMARK 470     LYS J  70    CG   CD   CE   NZ                                   
REMARK 470     GLU J 132    CG   CD   OE1  OE2                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    HOH C   397     O    HOH C   431              1.72            
REMARK 500   SG   CYS E   111     S4   S4P E   202              1.73            
REMARK 500   O    HOH A   336     O    HOH A   348              1.88            
REMARK 500   O    HOH A   411     O    HOH A   439              1.94            
REMARK 500   O    HOH A   354     O    HOH A   450              1.97            
REMARK 500   O    HOH B   347     O    HOH B   415              1.98            
REMARK 500   O    HOH B   464     O    HOH B   504              2.03            
REMARK 500   O    HOH A   461     O    HOH A   469              2.03            
REMARK 500   O    HOH A   451     O    HOH A   525              2.07            
REMARK 500   O    HOH B   323     O    HOH B   332              2.10            
REMARK 500   SG   CYS I     6     O    HOH I   317              2.12            
REMARK 500   O    HOH C   441     O    HOH E   358              2.13            
REMARK 500   O    HOH F   311     O    HOH F   347              2.15            
REMARK 500   O    HOH E   337     O    HOH E   342              2.17            
REMARK 500   O    HOH B   418     O    HOH B   444              2.17            
REMARK 500   O    HOH A   385     O    HOH A   511              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   O    HOH A   380     O    HOH D   414     3455     2.09            
REMARK 500   O    HOH C   431     O    HOH F   457     8555     2.14            
REMARK 500   O    HOH A   498     O    HOH H   431     4555     2.14            
REMARK 500   O    HOH C   351     O    HOH I   370     7455     2.16            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ARG C 115   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.0 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASP C  90     -167.32    -79.62                                   
REMARK 500    LYS E  75       30.97    -81.86                                   
REMARK 500    GLU E  78       78.01   -104.54                                   
REMARK 500    ASP E  90     -178.48    -68.80                                   
REMARK 500    LYS E 128       45.98    -97.55                                   
REMARK 500    ASN E 131      159.54    175.98                                   
REMARK 500    ASN F  26       12.00     57.82                                   
REMARK 500    THR G   2      -64.82     86.14                                   
REMARK 500    ASN G  26       30.47   -142.02                                   
REMARK 500    ASN G  65       76.36     58.62                                   
REMARK 500    ASP I  90     -179.50    -69.61                                   
REMARK 500    ASN J  26      -31.58     67.39                                   
REMARK 500    SER J  68       57.18     37.05                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 525                                                                      
REMARK 525 SOLVENT                                                              
REMARK 525                                                                      
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT                    
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST                  
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT                 
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE                       
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;                             
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE                  
REMARK 525 NUMBER; I=INSERTION CODE):                                           
REMARK 525                                                                      
REMARK 525  M RES CSSEQI                                                        
REMARK 525    HOH A 542        DISTANCE =  5.93 ANGSTROMS                       
REMARK 525    HOH A 543        DISTANCE =  6.35 ANGSTROMS                       
REMARK 525    HOH A 544        DISTANCE =  6.47 ANGSTROMS                       
REMARK 525    HOH H 470        DISTANCE =  6.46 ANGSTROMS                       
REMARK 525    HOH B 527        DISTANCE =  6.50 ANGSTROMS                       
REMARK 525    HOH B 528        DISTANCE =  7.18 ANGSTROMS                       
REMARK 525    HOH C 465        DISTANCE =  6.65 ANGSTROMS                       
REMARK 525    HOH D 540        DISTANCE =  7.03 ANGSTROMS                       
REMARK 525    HOH D 541        DISTANCE =  7.06 ANGSTROMS                       
REMARK 525    HOH F 478        DISTANCE =  6.93 ANGSTROMS                       
REMARK 525    HOH I 399        DISTANCE =  6.04 ANGSTROMS                       
REMARK 525    HOH I 400        DISTANCE =  6.24 ANGSTROMS                       
REMARK 525    HOH I 401        DISTANCE =  6.42 ANGSTROMS                       
REMARK 525    HOH J 398        DISTANCE =  6.53 ANGSTROMS                       
REMARK 525    HOH J 399        DISTANCE =  7.58 ANGSTROMS                       
REMARK 525    HOH J 400        DISTANCE =  7.98 ANGSTROMS                       
REMARK 610                                                                      
REMARK 610 MISSING HETEROATOM                                                   
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 610 I=INSERTION CODE):                                                   
REMARK 610   M RES C SSEQI                                                      
REMARK 610     5FW A  201                                                       
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN A 202  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS A  63   ND1                                                    
REMARK 620 2 HIS A  71   ND1 106.9                                              
REMARK 620 3 HIS A  80   ND1 112.1 126.1                                        
REMARK 620 4 ASP A  83   OD1 101.8  92.3 113.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN H 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS H  63   ND1                                                    
REMARK 620 2 HIS H  71   ND1 102.2                                              
REMARK 620 3 HIS H  80   ND1 109.7 123.8                                        
REMARK 620 4 ASP H  83   OD1 102.8  91.0 123.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS B  63   ND1                                                    
REMARK 620 2 HIS B  71   ND1 103.8                                              
REMARK 620 3 HIS B  80   ND1 113.6 124.0                                        
REMARK 620 4 ASP B  83   OD1 106.0  92.5 114.0                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN C 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS C  63   ND1                                                    
REMARK 620 2 HIS C  71   ND1 105.0                                              
REMARK 620 3 HIS C  80   ND1 116.1 120.4                                        
REMARK 620 4 ASP C  83   OD1 105.1  83.2 121.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN D 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS D  63   ND1                                                    
REMARK 620 2 HIS D  71   ND1 109.0                                              
REMARK 620 3 HIS D  80   ND1 110.1 124.3                                        
REMARK 620 4 ASP D  83   OD1 104.6  93.0 113.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN E 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS E  63   ND1                                                    
REMARK 620 2 HIS E  71   ND1 104.9                                              
REMARK 620 3 HIS E  80   ND1 113.9 119.5                                        
REMARK 620 4 ASP E  83   OD1 109.7 100.3 107.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN F 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS F  63   ND1                                                    
REMARK 620 2 HIS F  71   ND1 103.8                                              
REMARK 620 3 HIS F  80   ND1 110.0 126.5                                        
REMARK 620 4 ASP F  83   OD1 108.8  96.6 109.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN I 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS I  63   ND1                                                    
REMARK 620 2 HIS I  71   ND1 107.3                                              
REMARK 620 3 HIS I  80   ND1 110.6 119.2                                        
REMARK 620 4 ASP I  83   OD1 106.6  96.4 115.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN J 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS J  63   ND1                                                    
REMARK 620 2 HIS J  71   ND1  98.2                                              
REMARK 620 3 HIS J  80   ND1 113.0 121.9                                        
REMARK 620 4 ASP J  83   OD1 108.6 111.0 103.9                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 5FW A 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN A 202                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue TAM A 203                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue S4P A 204                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN H 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL H 202                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GOL B 202                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN C 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue S4P C 202                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN D 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN E 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue S4P E 202                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN F 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN I 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN J 201                  
DBREF  5YTU A    0   153  UNP    P00441   SODC_HUMAN       1    154             
DBREF  5YTU H    0   153  UNP    P00441   SODC_HUMAN       1    154             
DBREF  5YTU B    0   153  UNP    P00441   SODC_HUMAN       1    154             
DBREF  5YTU C    0   153  UNP    P00441   SODC_HUMAN       1    154             
DBREF  5YTU D    0   153  UNP    P00441   SODC_HUMAN       1    154             
DBREF  5YTU E    0   153  UNP    P00441   SODC_HUMAN       1    154             
DBREF  5YTU F    0   153  UNP    P00441   SODC_HUMAN       1    154             
DBREF  5YTU G    0   153  UNP    P00441   SODC_HUMAN       1    154             
DBREF  5YTU I    0   153  UNP    P00441   SODC_HUMAN       1    154             
DBREF  5YTU J    0   153  UNP    P00441   SODC_HUMAN       1    154             
SEQADV 5YTU MET A  -26  UNP  P00441              INITIATING METHIONINE          
SEQADV 5YTU LYS A  -25  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS A  -24  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS A  -23  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS A  -22  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS A  -21  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS A  -20  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS A  -19  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO A  -18  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET A  -17  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU SER A  -16  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP A  -15  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR A  -14  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP A  -13  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ILE A  -12  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO A  -11  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR A  -10  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR A   -9  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLU A   -8  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASN A   -7  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU LEU A   -6  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR A   -5  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PHE A   -4  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLN A   -3  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLY A   -2  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ALA A   -1  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET H  -26  UNP  P00441              INITIATING METHIONINE          
SEQADV 5YTU LYS H  -25  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS H  -24  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS H  -23  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS H  -22  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS H  -21  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS H  -20  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS H  -19  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO H  -18  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET H  -17  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU SER H  -16  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP H  -15  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR H  -14  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP H  -13  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ILE H  -12  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO H  -11  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR H  -10  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR H   -9  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLU H   -8  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASN H   -7  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU LEU H   -6  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR H   -5  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PHE H   -4  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLN H   -3  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLY H   -2  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ALA H   -1  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET B  -26  UNP  P00441              INITIATING METHIONINE          
SEQADV 5YTU LYS B  -25  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS B  -24  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS B  -23  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS B  -22  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS B  -21  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS B  -20  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS B  -19  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO B  -18  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET B  -17  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU SER B  -16  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP B  -15  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR B  -14  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP B  -13  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ILE B  -12  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO B  -11  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR B  -10  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR B   -9  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLU B   -8  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASN B   -7  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU LEU B   -6  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR B   -5  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PHE B   -4  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLN B   -3  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLY B   -2  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ALA B   -1  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET C  -26  UNP  P00441              INITIATING METHIONINE          
SEQADV 5YTU LYS C  -25  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS C  -24  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS C  -23  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS C  -22  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS C  -21  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS C  -20  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS C  -19  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO C  -18  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET C  -17  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU SER C  -16  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP C  -15  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR C  -14  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP C  -13  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ILE C  -12  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO C  -11  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR C  -10  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR C   -9  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLU C   -8  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASN C   -7  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU LEU C   -6  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR C   -5  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PHE C   -4  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLN C   -3  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLY C   -2  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ALA C   -1  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET D  -26  UNP  P00441              INITIATING METHIONINE          
SEQADV 5YTU LYS D  -25  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS D  -24  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS D  -23  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS D  -22  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS D  -21  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS D  -20  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS D  -19  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO D  -18  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET D  -17  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU SER D  -16  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP D  -15  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR D  -14  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP D  -13  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ILE D  -12  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO D  -11  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR D  -10  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR D   -9  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLU D   -8  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASN D   -7  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU LEU D   -6  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR D   -5  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PHE D   -4  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLN D   -3  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLY D   -2  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ALA D   -1  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET E  -26  UNP  P00441              INITIATING METHIONINE          
SEQADV 5YTU LYS E  -25  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS E  -24  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS E  -23  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS E  -22  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS E  -21  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS E  -20  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS E  -19  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO E  -18  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET E  -17  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU SER E  -16  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP E  -15  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR E  -14  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP E  -13  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ILE E  -12  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO E  -11  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR E  -10  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR E   -9  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLU E   -8  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASN E   -7  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU LEU E   -6  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR E   -5  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PHE E   -4  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLN E   -3  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLY E   -2  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ALA E   -1  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET F  -26  UNP  P00441              INITIATING METHIONINE          
SEQADV 5YTU LYS F  -25  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS F  -24  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS F  -23  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS F  -22  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS F  -21  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS F  -20  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS F  -19  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO F  -18  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET F  -17  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU SER F  -16  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP F  -15  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR F  -14  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP F  -13  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ILE F  -12  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO F  -11  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR F  -10  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR F   -9  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLU F   -8  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASN F   -7  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU LEU F   -6  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR F   -5  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PHE F   -4  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLN F   -3  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLY F   -2  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ALA F   -1  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET G  -26  UNP  P00441              INITIATING METHIONINE          
SEQADV 5YTU LYS G  -25  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS G  -24  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS G  -23  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS G  -22  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS G  -21  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS G  -20  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS G  -19  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO G  -18  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET G  -17  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU SER G  -16  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP G  -15  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR G  -14  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP G  -13  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ILE G  -12  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO G  -11  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR G  -10  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR G   -9  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLU G   -8  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASN G   -7  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU LEU G   -6  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR G   -5  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PHE G   -4  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLN G   -3  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLY G   -2  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ALA G   -1  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET I  -26  UNP  P00441              INITIATING METHIONINE          
SEQADV 5YTU LYS I  -25  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS I  -24  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS I  -23  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS I  -22  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS I  -21  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS I  -20  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS I  -19  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO I  -18  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET I  -17  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU SER I  -16  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP I  -15  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR I  -14  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP I  -13  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ILE I  -12  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO I  -11  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR I  -10  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR I   -9  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLU I   -8  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASN I   -7  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU LEU I   -6  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR I   -5  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PHE I   -4  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLN I   -3  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLY I   -2  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ALA I   -1  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET J  -26  UNP  P00441              INITIATING METHIONINE          
SEQADV 5YTU LYS J  -25  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS J  -24  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS J  -23  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS J  -22  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS J  -21  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS J  -20  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU HIS J  -19  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO J  -18  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU MET J  -17  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU SER J  -16  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP J  -15  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR J  -14  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASP J  -13  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ILE J  -12  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PRO J  -11  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR J  -10  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU THR J   -9  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLU J   -8  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ASN J   -7  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU LEU J   -6  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU TYR J   -5  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU PHE J   -4  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLN J   -3  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU GLY J   -2  UNP  P00441              EXPRESSION TAG                 
SEQADV 5YTU ALA J   -1  UNP  P00441              EXPRESSION TAG                 
SEQRES   1 A  180  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 A  180  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 A  180  MET ALA THR LYS ALA VAL CYS VAL LEU LYS GLY ASP GLY          
SEQRES   4 A  180  PRO VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER          
SEQRES   5 A  180  ASN GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU          
SEQRES   6 A  180  THR GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY          
SEQRES   7 A  180  ASP ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE          
SEQRES   8 A  180  ASN PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU          
SEQRES   9 A  180  GLU ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP          
SEQRES  10 A  180  LYS ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL          
SEQRES  11 A  180  ILE SER LEU SER GLY ASP HIS CYS ILE ILE GLY ARG THR          
SEQRES  12 A  180  LEU VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY          
SEQRES  13 A  180  GLY ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER          
SEQRES  14 A  180  ARG LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                  
SEQRES   1 H  180  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 H  180  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 H  180  MET ALA THR LYS ALA VAL CYS VAL LEU LYS GLY ASP GLY          
SEQRES   4 H  180  PRO VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER          
SEQRES   5 H  180  ASN GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU          
SEQRES   6 H  180  THR GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY          
SEQRES   7 H  180  ASP ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE          
SEQRES   8 H  180  ASN PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU          
SEQRES   9 H  180  GLU ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP          
SEQRES  10 H  180  LYS ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL          
SEQRES  11 H  180  ILE SER LEU SER GLY ASP HIS CYS ILE ILE GLY ARG THR          
SEQRES  12 H  180  LEU VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY          
SEQRES  13 H  180  GLY ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER          
SEQRES  14 H  180  ARG LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                  
SEQRES   1 B  180  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 B  180  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 B  180  MET ALA THR LYS ALA VAL CYS VAL LEU LYS GLY ASP GLY          
SEQRES   4 B  180  PRO VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER          
SEQRES   5 B  180  ASN GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU          
SEQRES   6 B  180  THR GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY          
SEQRES   7 B  180  ASP ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE          
SEQRES   8 B  180  ASN PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU          
SEQRES   9 B  180  GLU ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP          
SEQRES  10 B  180  LYS ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL          
SEQRES  11 B  180  ILE SER LEU SER GLY ASP HIS CYS ILE ILE GLY ARG THR          
SEQRES  12 B  180  LEU VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY          
SEQRES  13 B  180  GLY ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER          
SEQRES  14 B  180  ARG LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                  
SEQRES   1 C  180  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 C  180  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 C  180  MET ALA THR LYS ALA VAL CYS VAL LEU LYS GLY ASP GLY          
SEQRES   4 C  180  PRO VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER          
SEQRES   5 C  180  ASN GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU          
SEQRES   6 C  180  THR GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY          
SEQRES   7 C  180  ASP ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE          
SEQRES   8 C  180  ASN PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU          
SEQRES   9 C  180  GLU ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP          
SEQRES  10 C  180  LYS ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL          
SEQRES  11 C  180  ILE SER LEU SER GLY ASP HIS CYS ILE ILE GLY ARG THR          
SEQRES  12 C  180  LEU VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY          
SEQRES  13 C  180  GLY ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER          
SEQRES  14 C  180  ARG LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                  
SEQRES   1 D  180  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 D  180  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 D  180  MET ALA THR LYS ALA VAL CYS VAL LEU LYS GLY ASP GLY          
SEQRES   4 D  180  PRO VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER          
SEQRES   5 D  180  ASN GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU          
SEQRES   6 D  180  THR GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY          
SEQRES   7 D  180  ASP ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE          
SEQRES   8 D  180  ASN PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU          
SEQRES   9 D  180  GLU ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP          
SEQRES  10 D  180  LYS ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL          
SEQRES  11 D  180  ILE SER LEU SER GLY ASP HIS CYS ILE ILE GLY ARG THR          
SEQRES  12 D  180  LEU VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY          
SEQRES  13 D  180  GLY ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER          
SEQRES  14 D  180  ARG LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                  
SEQRES   1 E  180  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 E  180  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 E  180  MET ALA THR LYS ALA VAL CYS VAL LEU LYS GLY ASP GLY          
SEQRES   4 E  180  PRO VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER          
SEQRES   5 E  180  ASN GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU          
SEQRES   6 E  180  THR GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY          
SEQRES   7 E  180  ASP ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE          
SEQRES   8 E  180  ASN PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU          
SEQRES   9 E  180  GLU ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP          
SEQRES  10 E  180  LYS ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL          
SEQRES  11 E  180  ILE SER LEU SER GLY ASP HIS CYS ILE ILE GLY ARG THR          
SEQRES  12 E  180  LEU VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY          
SEQRES  13 E  180  GLY ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER          
SEQRES  14 E  180  ARG LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                  
SEQRES   1 F  180  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 F  180  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 F  180  MET ALA THR LYS ALA VAL CYS VAL LEU LYS GLY ASP GLY          
SEQRES   4 F  180  PRO VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER          
SEQRES   5 F  180  ASN GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU          
SEQRES   6 F  180  THR GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY          
SEQRES   7 F  180  ASP ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE          
SEQRES   8 F  180  ASN PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU          
SEQRES   9 F  180  GLU ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP          
SEQRES  10 F  180  LYS ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL          
SEQRES  11 F  180  ILE SER LEU SER GLY ASP HIS CYS ILE ILE GLY ARG THR          
SEQRES  12 F  180  LEU VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY          
SEQRES  13 F  180  GLY ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER          
SEQRES  14 F  180  ARG LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                  
SEQRES   1 G  180  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 G  180  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 G  180  MET ALA THR LYS ALA VAL CYS VAL LEU LYS GLY ASP GLY          
SEQRES   4 G  180  PRO VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER          
SEQRES   5 G  180  ASN GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU          
SEQRES   6 G  180  THR GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY          
SEQRES   7 G  180  ASP ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE          
SEQRES   8 G  180  ASN PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU          
SEQRES   9 G  180  GLU ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP          
SEQRES  10 G  180  LYS ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL          
SEQRES  11 G  180  ILE SER LEU SER GLY ASP HIS CYS ILE ILE GLY ARG THR          
SEQRES  12 G  180  LEU VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY          
SEQRES  13 G  180  GLY ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER          
SEQRES  14 G  180  ARG LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                  
SEQRES   1 I  180  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 I  180  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 I  180  MET ALA THR LYS ALA VAL CYS VAL LEU LYS GLY ASP GLY          
SEQRES   4 I  180  PRO VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER          
SEQRES   5 I  180  ASN GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU          
SEQRES   6 I  180  THR GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY          
SEQRES   7 I  180  ASP ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE          
SEQRES   8 I  180  ASN PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU          
SEQRES   9 I  180  GLU ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP          
SEQRES  10 I  180  LYS ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL          
SEQRES  11 I  180  ILE SER LEU SER GLY ASP HIS CYS ILE ILE GLY ARG THR          
SEQRES  12 I  180  LEU VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY          
SEQRES  13 I  180  GLY ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER          
SEQRES  14 I  180  ARG LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                  
SEQRES   1 J  180  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 J  180  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 J  180  MET ALA THR LYS ALA VAL CYS VAL LEU LYS GLY ASP GLY          
SEQRES   4 J  180  PRO VAL GLN GLY ILE ILE ASN PHE GLU GLN LYS GLU SER          
SEQRES   5 J  180  ASN GLY PRO VAL LYS VAL TRP GLY SER ILE LYS GLY LEU          
SEQRES   6 J  180  THR GLU GLY LEU HIS GLY PHE HIS VAL HIS GLU PHE GLY          
SEQRES   7 J  180  ASP ASN THR ALA GLY CYS THR SER ALA GLY PRO HIS PHE          
SEQRES   8 J  180  ASN PRO LEU SER ARG LYS HIS GLY GLY PRO LYS ASP GLU          
SEQRES   9 J  180  GLU ARG HIS VAL GLY ASP LEU GLY ASN VAL THR ALA ASP          
SEQRES  10 J  180  LYS ASP GLY VAL ALA ASP VAL SER ILE GLU ASP SER VAL          
SEQRES  11 J  180  ILE SER LEU SER GLY ASP HIS CYS ILE ILE GLY ARG THR          
SEQRES  12 J  180  LEU VAL VAL HIS GLU LYS ALA ASP ASP LEU GLY LYS GLY          
SEQRES  13 J  180  GLY ASN GLU GLU SER THR LYS THR GLY ASN ALA GLY SER          
SEQRES  14 J  180  ARG LEU ALA CYS GLY VAL ILE GLY ILE ALA GLN                  
HET    5FW  A 201      10                                                       
HET     ZN  A 202       1                                                       
HET    TAM  A 203      11                                                       
HET    S4P  A 204       4                                                       
HET     ZN  H 201       1                                                       
HET    GOL  H 202       6                                                       
HET     ZN  B 201       1                                                       
HET    GOL  B 202       6                                                       
HET     ZN  C 201       1                                                       
HET    S4P  C 202       4                                                       
HET     ZN  D 201       1                                                       
HET     ZN  E 201       1                                                       
HET    S4P  E 202       4                                                       
HET     ZN  F 201       1                                                       
HET     ZN  I 201       1                                                       
HET     ZN  J 201       1                                                       
HETNAM     5FW ISOPRENALINE                                                     
HETNAM      ZN ZINC ION                                                         
HETNAM     TAM TRIS(HYDROXYETHYL)AMINOMETHANE                                   
HETNAM     S4P DIHYDROGEN TETRASULFIDE                                          
HETNAM     GOL GLYCEROL                                                         
HETSYN     S4P TETRASULFANE                                                     
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL                                    
FORMUL  11  5FW    C11 H17 N O3                                                 
FORMUL  12   ZN    9(ZN 2+)                                                     
FORMUL  13  TAM    C7 H17 N O3                                                  
FORMUL  14  S4P    3(H2 S4)                                                     
FORMUL  16  GOL    2(C3 H8 O3)                                                  
FORMUL  27  HOH   *1631(H2 O)                                                   
HELIX    1 AA1 ALA A   55  GLY A   61  5                                   7    
HELIX    2 AA2 SER A  107  CYS A  111  5                                   5    
HELIX    3 AA3 GLU A  133  GLY A  138  1                                   6    
HELIX    4 AA4 ALA H   55  GLY H   61  5                                   7    
HELIX    5 AA5 ASN H  131  THR H  137  1                                   7    
HELIX    6 AA6 ALA B   55  GLY B   61  5                                   7    
HELIX    7 AA7 SER B  107  CYS B  111  5                                   5    
HELIX    8 AA8 GLU B  133  GLY B  138  1                                   6    
HELIX    9 AA9 ALA C   55  GLY C   61  5                                   7    
HELIX   10 AB1 ASN C  131  THR C  135  5                                   5    
HELIX   11 AB2 ALA D   55  GLY D   61  5                                   7    
HELIX   12 AB3 SER D  107  CYS D  111  5                                   5    
HELIX   13 AB4 GLU D  133  GLY D  138  1                                   6    
HELIX   14 AB5 ALA E   55  GLY E   61  5                                   7    
HELIX   15 AB6 ASN E  131  THR E  135  5                                   5    
HELIX   16 AB7 ALA F   55  GLY F   61  5                                   7    
HELIX   17 AB8 GLU F  133  GLY F  138  1                                   6    
HELIX   18 AB9 ALA G   55  GLY G   61  5                                   7    
HELIX   19 AC1 SER G  107  CYS G  111  5                                   5    
HELIX   20 AC2 ALA I   55  GLY I   61  5                                   7    
HELIX   21 AC3 SER I  107  CYS I  111  5                                   5    
HELIX   22 AC4 GLU I  133  GLY I  138  1                                   6    
HELIX   23 AC5 ALA J   55  GLY J   61  5                                   7    
HELIX   24 AC6 ASN J  131  THR J  137  1                                   7    
SHEET    1 AA1 5 ALA A  95  ASP A 101  0                                        
SHEET    2 AA1 5 VAL A  29  LYS A  36 -1  N  VAL A  29   O  ASP A 101           
SHEET    3 AA1 5 GLN A  15  GLU A  21 -1  N  ASN A  19   O  TRP A  32           
SHEET    4 AA1 5 LYS A   3  LEU A   8 -1  N  CYS A   6   O  ILE A  18           
SHEET    5 AA1 5 GLY A 150  ILE A 151 -1  O  GLY A 150   N  VAL A   5           
SHEET    1 AA2 4 ASP A  83  ALA A  89  0                                        
SHEET    2 AA2 4 GLY A  41  HIS A  48 -1  N  GLY A  41   O  ALA A  89           
SHEET    3 AA2 4 THR A 116  HIS A 120 -1  O  THR A 116   N  HIS A  48           
SHEET    4 AA2 4 ARG A 143  VAL A 148 -1  O  ALA A 145   N  VAL A 119           
SHEET    1 AA3 5 ALA H  95  ASP H 101  0                                        
SHEET    2 AA3 5 VAL H  29  LYS H  36 -1  N  VAL H  29   O  ASP H 101           
SHEET    3 AA3 5 GLN H  15  GLU H  21 -1  N  GLN H  15   O  LYS H  36           
SHEET    4 AA3 5 LYS H   3  LEU H   8 -1  N  LEU H   8   O  GLY H  16           
SHEET    5 AA3 5 GLY H 150  ILE H 151 -1  O  GLY H 150   N  VAL H   5           
SHEET    1 AA4 4 ASP H  83  ALA H  89  0                                        
SHEET    2 AA4 4 GLY H  41  HIS H  48 -1  N  GLY H  41   O  ALA H  89           
SHEET    3 AA4 4 THR H 116  HIS H 120 -1  O  THR H 116   N  HIS H  48           
SHEET    4 AA4 4 ARG H 143  VAL H 148 -1  O  GLY H 147   N  LEU H 117           
SHEET    1 AA5 5 ALA B  95  ASP B 101  0                                        
SHEET    2 AA5 5 VAL B  29  LYS B  36 -1  N  VAL B  31   O  ILE B  99           
SHEET    3 AA5 5 GLN B  15  GLU B  21 -1  N  ASN B  19   O  TRP B  32           
SHEET    4 AA5 5 LYS B   3  LEU B   8 -1  N  CYS B   6   O  ILE B  18           
SHEET    5 AA5 5 GLY B 150  ILE B 151 -1  O  GLY B 150   N  VAL B   5           
SHEET    1 AA6 4 ASP B  83  ALA B  89  0                                        
SHEET    2 AA6 4 GLY B  41  HIS B  48 -1  N  GLY B  41   O  ALA B  89           
SHEET    3 AA6 4 THR B 116  HIS B 120 -1  O  THR B 116   N  HIS B  48           
SHEET    4 AA6 4 ARG B 143  VAL B 148 -1  O  ALA B 145   N  VAL B 119           
SHEET    1 AA7 5 ALA C  95  ASP C 101  0                                        
SHEET    2 AA7 5 VAL C  29  LYS C  36 -1  N  VAL C  29   O  ASP C 101           
SHEET    3 AA7 5 GLN C  15  GLU C  21 -1  N  ASN C  19   O  TRP C  32           
SHEET    4 AA7 5 LYS C   3  LEU C   8 -1  N  LEU C   8   O  GLY C  16           
SHEET    5 AA7 5 GLY C 150  ILE C 151 -1  O  GLY C 150   N  VAL C   5           
SHEET    1 AA8 4 ASP C  83  ALA C  89  0                                        
SHEET    2 AA8 4 GLY C  41  HIS C  48 -1  N  GLY C  41   O  ALA C  89           
SHEET    3 AA8 4 THR C 116  HIS C 120 -1  O  THR C 116   N  HIS C  48           
SHEET    4 AA8 4 ARG C 143  VAL C 148 -1  O  GLY C 147   N  LEU C 117           
SHEET    1 AA9 5 ALA D  95  ASP D 101  0                                        
SHEET    2 AA9 5 VAL D  29  LYS D  36 -1  N  VAL D  31   O  ILE D  99           
SHEET    3 AA9 5 GLN D  15  GLU D  21 -1  N  ASN D  19   O  TRP D  32           
SHEET    4 AA9 5 LYS D   3  LEU D   8 -1  N  LEU D   8   O  GLY D  16           
SHEET    5 AA9 5 GLY D 150  ILE D 151 -1  O  GLY D 150   N  VAL D   5           
SHEET    1 AB1 4 ASP D  83  ALA D  89  0                                        
SHEET    2 AB1 4 GLY D  41  HIS D  48 -1  N  GLY D  41   O  ALA D  89           
SHEET    3 AB1 4 THR D 116  HIS D 120 -1  O  THR D 116   N  HIS D  48           
SHEET    4 AB1 4 ARG D 143  VAL D 148 -1  O  ALA D 145   N  VAL D 119           
SHEET    1 AB2 5 ALA E  95  ASP E 101  0                                        
SHEET    2 AB2 5 VAL E  29  LYS E  36 -1  N  VAL E  29   O  ASP E 101           
SHEET    3 AB2 5 GLN E  15  GLU E  21 -1  N  ASN E  19   O  TRP E  32           
SHEET    4 AB2 5 LYS E   3  LEU E   8 -1  N  LEU E   8   O  GLY E  16           
SHEET    5 AB2 5 GLY E 150  ILE E 151 -1  O  GLY E 150   N  VAL E   5           
SHEET    1 AB3 4 ASP E  83  ALA E  89  0                                        
SHEET    2 AB3 4 GLY E  41  HIS E  48 -1  N  GLY E  41   O  ALA E  89           
SHEET    3 AB3 4 THR E 116  HIS E 120 -1  O  THR E 116   N  HIS E  48           
SHEET    4 AB3 4 ARG E 143  VAL E 148 -1  O  GLY E 147   N  LEU E 117           
SHEET    1 AB4 5 ALA F  95  ASP F 101  0                                        
SHEET    2 AB4 5 VAL F  29  LYS F  36 -1  N  VAL F  31   O  ILE F  99           
SHEET    3 AB4 5 GLN F  15  GLU F  21 -1  N  ASN F  19   O  TRP F  32           
SHEET    4 AB4 5 LYS F   3  LYS F   9 -1  N  ALA F   4   O  PHE F  20           
SHEET    5 AB4 5 GLY F 150  ILE F 151 -1  O  GLY F 150   N  VAL F   5           
SHEET    1 AB5 4 ASP F  83  ALA F  89  0                                        
SHEET    2 AB5 4 GLY F  41  HIS F  48 -1  N  HIS F  43   O  VAL F  87           
SHEET    3 AB5 4 THR F 116  HIS F 120 -1  O  THR F 116   N  HIS F  48           
SHEET    4 AB5 4 ARG F 143  VAL F 148 -1  O  ALA F 145   N  VAL F 119           
SHEET    1 AB6 5 ALA G  95  ASP G 101  0                                        
SHEET    2 AB6 5 VAL G  29  LYS G  36 -1  N  VAL G  31   O  ILE G  99           
SHEET    3 AB6 5 GLN G  15  GLN G  22 -1  N  ASN G  19   O  TRP G  32           
SHEET    4 AB6 5 LYS G   3  LEU G   8 -1  N  ALA G   4   O  PHE G  20           
SHEET    5 AB6 5 GLY G 150  ILE G 151 -1  O  GLY G 150   N  VAL G   5           
SHEET    1 AB7 4 ASP G  83  ALA G  89  0                                        
SHEET    2 AB7 4 GLY G  41  HIS G  48 -1  N  GLY G  41   O  ALA G  89           
SHEET    3 AB7 4 THR G 116  HIS G 120 -1  O  THR G 116   N  HIS G  48           
SHEET    4 AB7 4 ARG G 143  VAL G 148 -1  O  ALA G 145   N  VAL G 119           
SHEET    1 AB8 5 ALA I  95  ASP I 101  0                                        
SHEET    2 AB8 5 VAL I  29  LYS I  36 -1  N  VAL I  29   O  ASP I 101           
SHEET    3 AB8 5 GLN I  15  GLU I  21 -1  N  GLN I  15   O  LYS I  36           
SHEET    4 AB8 5 LYS I   3  LYS I   9 -1  N  LEU I   8   O  GLY I  16           
SHEET    5 AB8 5 GLY I 150  ALA I 152 -1  O  GLY I 150   N  VAL I   5           
SHEET    1 AB9 4 ASP I  83  ALA I  89  0                                        
SHEET    2 AB9 4 GLY I  41  HIS I  48 -1  N  GLY I  41   O  ALA I  89           
SHEET    3 AB9 4 THR I 116  HIS I 120 -1  O  THR I 116   N  HIS I  48           
SHEET    4 AB9 4 ARG I 143  VAL I 148 -1  O  LEU I 144   N  VAL I 119           
SHEET    1 AC1 5 ALA J  95  ASP J 101  0                                        
SHEET    2 AC1 5 VAL J  29  LYS J  36 -1  N  VAL J  29   O  ASP J 101           
SHEET    3 AC1 5 GLN J  15  GLU J  21 -1  N  ASN J  19   O  TRP J  32           
SHEET    4 AC1 5 LYS J   3  LYS J   9 -1  N  LEU J   8   O  GLY J  16           
SHEET    5 AC1 5 GLY J 150  ILE J 151 -1  O  GLY J 150   N  VAL J   5           
SHEET    1 AC2 4 ASP J  83  ALA J  89  0                                        
SHEET    2 AC2 4 GLY J  41  HIS J  48 -1  N  GLY J  41   O  ALA J  89           
SHEET    3 AC2 4 THR J 116  HIS J 120 -1  O  THR J 116   N  HIS J  48           
SHEET    4 AC2 4 ARG J 143  VAL J 148 -1  O  LEU J 144   N  VAL J 119           
SSBOND   1 CYS A   57    CYS A  146                          1555   1555  2.22  
SSBOND   2 CYS H   57    CYS H  146                          1555   1555  2.23  
SSBOND   3 CYS B   57    CYS B  146                          1555   1555  2.21  
SSBOND   4 CYS C   57    CYS C  146                          1555   1555  2.20  
SSBOND   5 CYS D   57    CYS D  146                          1555   1555  2.20  
SSBOND   6 CYS E   57    CYS E  146                          1555   1555  2.18  
SSBOND   7 CYS F   57    CYS F  146                          1555   1555  2.13  
SSBOND   8 CYS G   57    CYS G  146                          1555   1555  2.19  
SSBOND   9 CYS I   57    CYS I  146                          1555   1555  2.13  
SSBOND  10 CYS J   57    CYS J  146                          1555   1555  2.12  
LINK         ND1 HIS A  63                ZN    ZN A 202     1555   1555  2.04  
LINK         ND1 HIS A  71                ZN    ZN A 202     1555   1555  2.18  
LINK         ND1 HIS A  80                ZN    ZN A 202     1555   1555  2.02  
LINK         OD1 ASP A  83                ZN    ZN A 202     1555   1555  1.88  
LINK         ND1 HIS H  63                ZN    ZN H 201     1555   1555  2.25  
LINK         ND1 HIS H  71                ZN    ZN H 201     1555   1555  2.23  
LINK         ND1 HIS H  80                ZN    ZN H 201     1555   1555  2.01  
LINK         OD1 ASP H  83                ZN    ZN H 201     1555   1555  1.82  
LINK         ND1 HIS B  63                ZN    ZN B 201     1555   1555  2.08  
LINK         ND1 HIS B  71                ZN    ZN B 201     1555   1555  2.20  
LINK         ND1 HIS B  80                ZN    ZN B 201     1555   1555  2.03  
LINK         OD1 ASP B  83                ZN    ZN B 201     1555   1555  1.94  
LINK         ND1 HIS C  63                ZN    ZN C 201     1555   1555  2.14  
LINK         ND1 HIS C  71                ZN    ZN C 201     1555   1555  2.35  
LINK         ND1 HIS C  80                ZN    ZN C 201     1555   1555  1.98  
LINK         OD1 ASP C  83                ZN    ZN C 201     1555   1555  1.90  
LINK         ND1 HIS D  63                ZN    ZN D 201     1555   1555  2.05  
LINK         ND1 HIS D  71                ZN    ZN D 201     1555   1555  2.12  
LINK         ND1 HIS D  80                ZN    ZN D 201     1555   1555  2.05  
LINK         OD1 ASP D  83                ZN    ZN D 201     1555   1555  1.95  
LINK         ND1 HIS E  63                ZN    ZN E 201     1555   1555  2.08  
LINK         ND1 HIS E  71                ZN    ZN E 201     1555   1555  2.45  
LINK         ND1 HIS E  80                ZN    ZN E 201     1555   1555  2.04  
LINK         OD1 ASP E  83                ZN    ZN E 201     1555   1555  2.23  
LINK         ND1 HIS F  63                ZN    ZN F 201     1555   1555  2.16  
LINK         ND1 HIS F  71                ZN    ZN F 201     1555   1555  2.06  
LINK         ND1 HIS F  80                ZN    ZN F 201     1555   1555  2.07  
LINK         OD1 ASP F  83                ZN    ZN F 201     1555   1555  1.96  
LINK         ND1 HIS I  63                ZN    ZN I 201     1555   1555  2.12  
LINK         ND1 HIS I  71                ZN    ZN I 201     1555   1555  2.21  
LINK         ND1 HIS I  80                ZN    ZN I 201     1555   1555  2.07  
LINK         OD1 ASP I  83                ZN    ZN I 201     1555   1555  2.01  
LINK         ND1 HIS J  63                ZN    ZN J 201     1555   1555  2.11  
LINK         ND1 HIS J  71                ZN    ZN J 201     1555   1555  2.54  
LINK         ND1 HIS J  80                ZN    ZN J 201     1555   1555  2.21  
LINK         OD1 ASP J  83                ZN    ZN J 201     1555   1555  2.10  
SITE     1 AC1  7 ASP A  11  PRO A  13  HOH A 339  HOH A 381                    
SITE     2 AC1  7 LYS H   9  GLY H  10  GLN H  15                               
SITE     1 AC2  4 HIS A  63  HIS A  71  HIS A  80  ASP A  83                    
SITE     1 AC3 12 HIS A  48  HIS A  63  HIS A 120  GLY A 141                    
SITE     2 AC3 12 SER A 142  ARG A 143  HOH A 335  HOH A 361                    
SITE     3 AC3 12 HOH A 391  HOH A 396  HOH A 399  HOH A 485                    
SITE     1 AC4  5 CYS A 111  ILE A 113  HOH A 514  CYS H 111                    
SITE     2 AC4  5 ILE H 113                                                     
SITE     1 AC5  4 HIS H  63  HIS H  71  HIS H  80  ASP H  83                    
SITE     1 AC6  4 LYS H  30  TRP H  32  HOH H 302  HOH H 442                    
SITE     1 AC7  4 HIS B  63  HIS B  71  HIS B  80  ASP B  83                    
SITE     1 AC8  9 LEU B  38  THR B  39  GLU B  40  LYS B  91                    
SITE     2 AC8  9 GLY B  93  HOH B 302  ASP G  11  GLY G  12                    
SITE     3 AC8  9 PRO G  13                                                     
SITE     1 AC9  5 HIS C  63  HIS C  71  HIS C  80  ASP C  83                    
SITE     2 AC9  5 LYS C 136                                                     
SITE     1 AD1  7 CYS B 111  ILE B 113  HOH B 337  HOH B 488                    
SITE     2 AD1  7 CYS C 111  HOH C 339  HOH C 450                               
SITE     1 AD2  4 HIS D  63  HIS D  71  HIS D  80  ASP D  83                    
SITE     1 AD3  4 HIS E  63  HIS E  71  HIS E  80  ASP E  83                    
SITE     1 AD4  4 CYS D 111  ILE D 113  CYS E 111  HOH E 309                    
SITE     1 AD5  4 HIS F  63  HIS F  71  HIS F  80  ASP F  83                    
SITE     1 AD6  4 HIS I  63  HIS I  71  HIS I  80  ASP I  83                    
SITE     1 AD7  4 HIS J  63  HIS J  71  HIS J  80  ASP J  83                    
CRYST1  164.521  203.791  144.771  90.00  90.00  90.00 C 2 2 21     80          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.006078  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.004907  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.006907        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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