HEADER TRANSPORT PROTEIN 18-NOV-17 6BO9
TITLE CRYO-EM STRUCTURE OF HUMAN TRPV6 IN AMPHIPOLS
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V
COMPND 3 MEMBER 6;
COMPND 4 CHAIN: A, B, C, D;
COMPND 5 SYNONYM: TRPV6,CAT-LIKE,CAT-L,CALCIUM TRANSPORT PROTEIN 1,CAT1,
COMPND 6 EPITHELIAL CALCIUM CHANNEL 2,ECAC2;
COMPND 7 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: TRPV6, ECAC2;
SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606
KEYWDS ION CHANNEL, MEMBRANE PROTEIN, TRANSPORT PROTEIN
EXPDTA ELECTRON MICROSCOPY
AUTHOR L.L.MCGOLDRICK,A.K.SINGH,K.SAOTOME,M.V.YELSHANSKAYA,E.C.TWOMEY,
AUTHOR 2 R.A.GRASSUCCI,A.I.SOBOLEVSKY
REVDAT 7 13-MAR-24 6BO9 1 REMARK
REVDAT 6 18-DEC-19 6BO9 1 SCALE
REVDAT 5 04-DEC-19 6BO9 1 REMARK
REVDAT 4 24-JAN-18 6BO9 1 JRNL
REVDAT 3 17-JAN-18 6BO9 1 REMARK
REVDAT 2 03-JAN-18 6BO9 1 JRNL
REVDAT 1 20-DEC-17 6BO9 0
JRNL AUTH L.L.MCGOLDRICK,A.K.SINGH,K.SAOTOME,M.V.YELSHANSKAYA,
JRNL AUTH 2 E.C.TWOMEY,R.A.GRASSUCCI,A.I.SOBOLEVSKY
JRNL TITL OPENING OF THE HUMAN EPITHELIAL CALCIUM CHANNEL TRPV6.
JRNL REF NATURE V. 553 233 2018
JRNL REFN ESSN 1476-4687
JRNL PMID 29258289
JRNL DOI 10.1038/NATURE25182
REMARK 2
REMARK 2 RESOLUTION. 4.00 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : RELION
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : REAL
REMARK 3 REFINEMENT PROTOCOL : OTHER
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.000
REMARK 3 NUMBER OF PARTICLES : 65259
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 6BO9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 20-NOV-17.
REMARK 100 THE DEPOSITION ID IS D_1000231195.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : TRPV6 ION CHANNEL IN OPEN
REMARK 245 STATES
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.30
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 8.00
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TECNAI F30
REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 6700.00
REMARK 245 ILLUMINATION MODE : SPOT SCAN
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 GLY A 2
REMARK 465 LEU A 3
REMARK 465 SER A 4
REMARK 465 LEU A 5
REMARK 465 PRO A 6
REMARK 465 LYS A 7
REMARK 465 GLU A 8
REMARK 465 LYS A 9
REMARK 465 GLY A 10
REMARK 465 LEU A 11
REMARK 465 ILE A 12
REMARK 465 LEU A 13
REMARK 465 CYS A 14
REMARK 465 LEU A 15
REMARK 465 TRP A 16
REMARK 465 SER A 17
REMARK 465 LYS A 18
REMARK 465 PHE A 19
REMARK 465 CYS A 20
REMARK 465 ARG A 21
REMARK 465 TRP A 22
REMARK 465 PHE A 23
REMARK 465 GLN A 24
REMARK 465 ARG A 25
REMARK 465 ARG A 26
REMARK 465 GLU A 27
REMARK 465 ASP A 406
REMARK 465 ILE A 407
REMARK 465 PHE A 408
REMARK 465 ARG A 409
REMARK 465 MET A 410
REMARK 465 GLY A 411
REMARK 465 VAL A 412
REMARK 465 THR A 413
REMARK 465 ARG A 414
REMARK 465 PHE A 415
REMARK 465 PHE A 416
REMARK 465 GLY A 417
REMARK 465 GLN A 418
REMARK 465 THR A 419
REMARK 465 ILE A 420
REMARK 465 LEU A 421
REMARK 465 GLY A 422
REMARK 465 GLY A 423
REMARK 465 LEU A 639
REMARK 465 ASN A 640
REMARK 465 ARG A 641
REMARK 465 GLN A 642
REMARK 465 ARG A 643
REMARK 465 ILE A 644
REMARK 465 GLN A 645
REMARK 465 ARG A 646
REMARK 465 TYR A 647
REMARK 465 ALA A 648
REMARK 465 GLN A 649
REMARK 465 ALA A 650
REMARK 465 PHE A 651
REMARK 465 HIS A 652
REMARK 465 THR A 653
REMARK 465 ARG A 654
REMARK 465 GLY A 655
REMARK 465 SER A 656
REMARK 465 GLU A 657
REMARK 465 ASP A 658
REMARK 465 LEU A 659
REMARK 465 ASP A 660
REMARK 465 LYS A 661
REMARK 465 ASP A 662
REMARK 465 SER A 663
REMARK 465 VAL A 664
REMARK 465 GLU A 665
REMARK 465 LYS A 666
REMARK 465 LEU A 667
REMARK 465 GLU A 668
REMARK 465 LEU A 669
REMARK 465 GLY A 670
REMARK 465 CYS A 671
REMARK 465 PRO A 672
REMARK 465 PHE A 673
REMARK 465 SER A 674
REMARK 465 PRO A 675
REMARK 465 HIS A 676
REMARK 465 LEU A 677
REMARK 465 SER A 678
REMARK 465 LEU A 679
REMARK 465 PRO A 680
REMARK 465 MET A 681
REMARK 465 PRO A 682
REMARK 465 SER A 683
REMARK 465 VAL A 684
REMARK 465 SER A 685
REMARK 465 ARG A 686
REMARK 465 SER A 687
REMARK 465 THR A 688
REMARK 465 SER A 689
REMARK 465 ARG A 690
REMARK 465 SER A 691
REMARK 465 SER A 692
REMARK 465 ALA A 693
REMARK 465 ASN A 694
REMARK 465 TRP A 695
REMARK 465 GLU A 696
REMARK 465 ARG A 697
REMARK 465 LEU A 698
REMARK 465 ARG A 699
REMARK 465 GLN A 700
REMARK 465 GLY A 701
REMARK 465 THR A 702
REMARK 465 LEU A 703
REMARK 465 ARG A 704
REMARK 465 ARG A 705
REMARK 465 ASP A 706
REMARK 465 LEU A 707
REMARK 465 ARG A 708
REMARK 465 GLY A 709
REMARK 465 ILE A 710
REMARK 465 ILE A 711
REMARK 465 ASN A 712
REMARK 465 ARG A 713
REMARK 465 GLY A 714
REMARK 465 LEU A 715
REMARK 465 GLU A 716
REMARK 465 ASP A 717
REMARK 465 GLY A 718
REMARK 465 GLU A 719
REMARK 465 SER A 720
REMARK 465 TRP A 721
REMARK 465 GLU A 722
REMARK 465 TYR A 723
REMARK 465 GLN A 724
REMARK 465 ILE A 725
REMARK 465 LEU A 726
REMARK 465 VAL A 727
REMARK 465 PRO A 728
REMARK 465 ARG A 729
REMARK 465 GLY A 730
REMARK 465 SER A 731
REMARK 465 ALA A 732
REMARK 465 ALA A 733
REMARK 465 ALA A 734
REMARK 465 TRP A 735
REMARK 465 SER A 736
REMARK 465 HIS A 737
REMARK 465 PRO A 738
REMARK 465 GLN A 739
REMARK 465 PHE A 740
REMARK 465 GLU A 741
REMARK 465 LYS A 742
REMARK 465 MET B 1
REMARK 465 GLY B 2
REMARK 465 LEU B 3
REMARK 465 SER B 4
REMARK 465 LEU B 5
REMARK 465 PRO B 6
REMARK 465 LYS B 7
REMARK 465 GLU B 8
REMARK 465 LYS B 9
REMARK 465 GLY B 10
REMARK 465 LEU B 11
REMARK 465 ILE B 12
REMARK 465 LEU B 13
REMARK 465 CYS B 14
REMARK 465 LEU B 15
REMARK 465 TRP B 16
REMARK 465 SER B 17
REMARK 465 LYS B 18
REMARK 465 PHE B 19
REMARK 465 CYS B 20
REMARK 465 ARG B 21
REMARK 465 TRP B 22
REMARK 465 PHE B 23
REMARK 465 GLN B 24
REMARK 465 ARG B 25
REMARK 465 ARG B 26
REMARK 465 GLU B 27
REMARK 465 ASP B 406
REMARK 465 ILE B 407
REMARK 465 PHE B 408
REMARK 465 ARG B 409
REMARK 465 MET B 410
REMARK 465 GLY B 411
REMARK 465 VAL B 412
REMARK 465 THR B 413
REMARK 465 ARG B 414
REMARK 465 PHE B 415
REMARK 465 PHE B 416
REMARK 465 GLY B 417
REMARK 465 GLN B 418
REMARK 465 THR B 419
REMARK 465 ILE B 420
REMARK 465 LEU B 421
REMARK 465 GLY B 422
REMARK 465 GLY B 423
REMARK 465 LEU B 639
REMARK 465 ASN B 640
REMARK 465 ARG B 641
REMARK 465 GLN B 642
REMARK 465 ARG B 643
REMARK 465 ILE B 644
REMARK 465 GLN B 645
REMARK 465 ARG B 646
REMARK 465 TYR B 647
REMARK 465 ALA B 648
REMARK 465 GLN B 649
REMARK 465 ALA B 650
REMARK 465 PHE B 651
REMARK 465 HIS B 652
REMARK 465 THR B 653
REMARK 465 ARG B 654
REMARK 465 GLY B 655
REMARK 465 SER B 656
REMARK 465 GLU B 657
REMARK 465 ASP B 658
REMARK 465 LEU B 659
REMARK 465 ASP B 660
REMARK 465 LYS B 661
REMARK 465 ASP B 662
REMARK 465 SER B 663
REMARK 465 VAL B 664
REMARK 465 GLU B 665
REMARK 465 LYS B 666
REMARK 465 LEU B 667
REMARK 465 GLU B 668
REMARK 465 LEU B 669
REMARK 465 GLY B 670
REMARK 465 CYS B 671
REMARK 465 PRO B 672
REMARK 465 PHE B 673
REMARK 465 SER B 674
REMARK 465 PRO B 675
REMARK 465 HIS B 676
REMARK 465 LEU B 677
REMARK 465 SER B 678
REMARK 465 LEU B 679
REMARK 465 PRO B 680
REMARK 465 MET B 681
REMARK 465 PRO B 682
REMARK 465 SER B 683
REMARK 465 VAL B 684
REMARK 465 SER B 685
REMARK 465 ARG B 686
REMARK 465 SER B 687
REMARK 465 THR B 688
REMARK 465 SER B 689
REMARK 465 ARG B 690
REMARK 465 SER B 691
REMARK 465 SER B 692
REMARK 465 ALA B 693
REMARK 465 ASN B 694
REMARK 465 TRP B 695
REMARK 465 GLU B 696
REMARK 465 ARG B 697
REMARK 465 LEU B 698
REMARK 465 ARG B 699
REMARK 465 GLN B 700
REMARK 465 GLY B 701
REMARK 465 THR B 702
REMARK 465 LEU B 703
REMARK 465 ARG B 704
REMARK 465 ARG B 705
REMARK 465 ASP B 706
REMARK 465 LEU B 707
REMARK 465 ARG B 708
REMARK 465 GLY B 709
REMARK 465 ILE B 710
REMARK 465 ILE B 711
REMARK 465 ASN B 712
REMARK 465 ARG B 713
REMARK 465 GLY B 714
REMARK 465 LEU B 715
REMARK 465 GLU B 716
REMARK 465 ASP B 717
REMARK 465 GLY B 718
REMARK 465 GLU B 719
REMARK 465 SER B 720
REMARK 465 TRP B 721
REMARK 465 GLU B 722
REMARK 465 TYR B 723
REMARK 465 GLN B 724
REMARK 465 ILE B 725
REMARK 465 LEU B 726
REMARK 465 VAL B 727
REMARK 465 PRO B 728
REMARK 465 ARG B 729
REMARK 465 GLY B 730
REMARK 465 SER B 731
REMARK 465 ALA B 732
REMARK 465 ALA B 733
REMARK 465 ALA B 734
REMARK 465 TRP B 735
REMARK 465 SER B 736
REMARK 465 HIS B 737
REMARK 465 PRO B 738
REMARK 465 GLN B 739
REMARK 465 PHE B 740
REMARK 465 GLU B 741
REMARK 465 LYS B 742
REMARK 465 MET C 1
REMARK 465 GLY C 2
REMARK 465 LEU C 3
REMARK 465 SER C 4
REMARK 465 LEU C 5
REMARK 465 PRO C 6
REMARK 465 LYS C 7
REMARK 465 GLU C 8
REMARK 465 LYS C 9
REMARK 465 GLY C 10
REMARK 465 LEU C 11
REMARK 465 ILE C 12
REMARK 465 LEU C 13
REMARK 465 CYS C 14
REMARK 465 LEU C 15
REMARK 465 TRP C 16
REMARK 465 SER C 17
REMARK 465 LYS C 18
REMARK 465 PHE C 19
REMARK 465 CYS C 20
REMARK 465 ARG C 21
REMARK 465 TRP C 22
REMARK 465 PHE C 23
REMARK 465 GLN C 24
REMARK 465 ARG C 25
REMARK 465 ARG C 26
REMARK 465 GLU C 27
REMARK 465 ASP C 406
REMARK 465 ILE C 407
REMARK 465 PHE C 408
REMARK 465 ARG C 409
REMARK 465 MET C 410
REMARK 465 GLY C 411
REMARK 465 VAL C 412
REMARK 465 THR C 413
REMARK 465 ARG C 414
REMARK 465 PHE C 415
REMARK 465 PHE C 416
REMARK 465 GLY C 417
REMARK 465 GLN C 418
REMARK 465 THR C 419
REMARK 465 ILE C 420
REMARK 465 LEU C 421
REMARK 465 GLY C 422
REMARK 465 GLY C 423
REMARK 465 LEU C 639
REMARK 465 ASN C 640
REMARK 465 ARG C 641
REMARK 465 GLN C 642
REMARK 465 ARG C 643
REMARK 465 ILE C 644
REMARK 465 GLN C 645
REMARK 465 ARG C 646
REMARK 465 TYR C 647
REMARK 465 ALA C 648
REMARK 465 GLN C 649
REMARK 465 ALA C 650
REMARK 465 PHE C 651
REMARK 465 HIS C 652
REMARK 465 THR C 653
REMARK 465 ARG C 654
REMARK 465 GLY C 655
REMARK 465 SER C 656
REMARK 465 GLU C 657
REMARK 465 ASP C 658
REMARK 465 LEU C 659
REMARK 465 ASP C 660
REMARK 465 LYS C 661
REMARK 465 ASP C 662
REMARK 465 SER C 663
REMARK 465 VAL C 664
REMARK 465 GLU C 665
REMARK 465 LYS C 666
REMARK 465 LEU C 667
REMARK 465 GLU C 668
REMARK 465 LEU C 669
REMARK 465 GLY C 670
REMARK 465 CYS C 671
REMARK 465 PRO C 672
REMARK 465 PHE C 673
REMARK 465 SER C 674
REMARK 465 PRO C 675
REMARK 465 HIS C 676
REMARK 465 LEU C 677
REMARK 465 SER C 678
REMARK 465 LEU C 679
REMARK 465 PRO C 680
REMARK 465 MET C 681
REMARK 465 PRO C 682
REMARK 465 SER C 683
REMARK 465 VAL C 684
REMARK 465 SER C 685
REMARK 465 ARG C 686
REMARK 465 SER C 687
REMARK 465 THR C 688
REMARK 465 SER C 689
REMARK 465 ARG C 690
REMARK 465 SER C 691
REMARK 465 SER C 692
REMARK 465 ALA C 693
REMARK 465 ASN C 694
REMARK 465 TRP C 695
REMARK 465 GLU C 696
REMARK 465 ARG C 697
REMARK 465 LEU C 698
REMARK 465 ARG C 699
REMARK 465 GLN C 700
REMARK 465 GLY C 701
REMARK 465 THR C 702
REMARK 465 LEU C 703
REMARK 465 ARG C 704
REMARK 465 ARG C 705
REMARK 465 ASP C 706
REMARK 465 LEU C 707
REMARK 465 ARG C 708
REMARK 465 GLY C 709
REMARK 465 ILE C 710
REMARK 465 ILE C 711
REMARK 465 ASN C 712
REMARK 465 ARG C 713
REMARK 465 GLY C 714
REMARK 465 LEU C 715
REMARK 465 GLU C 716
REMARK 465 ASP C 717
REMARK 465 GLY C 718
REMARK 465 GLU C 719
REMARK 465 SER C 720
REMARK 465 TRP C 721
REMARK 465 GLU C 722
REMARK 465 TYR C 723
REMARK 465 GLN C 724
REMARK 465 ILE C 725
REMARK 465 LEU C 726
REMARK 465 VAL C 727
REMARK 465 PRO C 728
REMARK 465 ARG C 729
REMARK 465 GLY C 730
REMARK 465 SER C 731
REMARK 465 ALA C 732
REMARK 465 ALA C 733
REMARK 465 ALA C 734
REMARK 465 TRP C 735
REMARK 465 SER C 736
REMARK 465 HIS C 737
REMARK 465 PRO C 738
REMARK 465 GLN C 739
REMARK 465 PHE C 740
REMARK 465 GLU C 741
REMARK 465 LYS C 742
REMARK 465 MET D 1
REMARK 465 GLY D 2
REMARK 465 LEU D 3
REMARK 465 SER D 4
REMARK 465 LEU D 5
REMARK 465 PRO D 6
REMARK 465 LYS D 7
REMARK 465 GLU D 8
REMARK 465 LYS D 9
REMARK 465 GLY D 10
REMARK 465 LEU D 11
REMARK 465 ILE D 12
REMARK 465 LEU D 13
REMARK 465 CYS D 14
REMARK 465 LEU D 15
REMARK 465 TRP D 16
REMARK 465 SER D 17
REMARK 465 LYS D 18
REMARK 465 PHE D 19
REMARK 465 CYS D 20
REMARK 465 ARG D 21
REMARK 465 TRP D 22
REMARK 465 PHE D 23
REMARK 465 GLN D 24
REMARK 465 ARG D 25
REMARK 465 ARG D 26
REMARK 465 GLU D 27
REMARK 465 ASP D 406
REMARK 465 ILE D 407
REMARK 465 PHE D 408
REMARK 465 ARG D 409
REMARK 465 MET D 410
REMARK 465 GLY D 411
REMARK 465 VAL D 412
REMARK 465 THR D 413
REMARK 465 ARG D 414
REMARK 465 PHE D 415
REMARK 465 PHE D 416
REMARK 465 GLY D 417
REMARK 465 GLN D 418
REMARK 465 THR D 419
REMARK 465 ILE D 420
REMARK 465 LEU D 421
REMARK 465 GLY D 422
REMARK 465 GLY D 423
REMARK 465 LEU D 639
REMARK 465 ASN D 640
REMARK 465 ARG D 641
REMARK 465 GLN D 642
REMARK 465 ARG D 643
REMARK 465 ILE D 644
REMARK 465 GLN D 645
REMARK 465 ARG D 646
REMARK 465 TYR D 647
REMARK 465 ALA D 648
REMARK 465 GLN D 649
REMARK 465 ALA D 650
REMARK 465 PHE D 651
REMARK 465 HIS D 652
REMARK 465 THR D 653
REMARK 465 ARG D 654
REMARK 465 GLY D 655
REMARK 465 SER D 656
REMARK 465 GLU D 657
REMARK 465 ASP D 658
REMARK 465 LEU D 659
REMARK 465 ASP D 660
REMARK 465 LYS D 661
REMARK 465 ASP D 662
REMARK 465 SER D 663
REMARK 465 VAL D 664
REMARK 465 GLU D 665
REMARK 465 LYS D 666
REMARK 465 LEU D 667
REMARK 465 GLU D 668
REMARK 465 LEU D 669
REMARK 465 GLY D 670
REMARK 465 CYS D 671
REMARK 465 PRO D 672
REMARK 465 PHE D 673
REMARK 465 SER D 674
REMARK 465 PRO D 675
REMARK 465 HIS D 676
REMARK 465 LEU D 677
REMARK 465 SER D 678
REMARK 465 LEU D 679
REMARK 465 PRO D 680
REMARK 465 MET D 681
REMARK 465 PRO D 682
REMARK 465 SER D 683
REMARK 465 VAL D 684
REMARK 465 SER D 685
REMARK 465 ARG D 686
REMARK 465 SER D 687
REMARK 465 THR D 688
REMARK 465 SER D 689
REMARK 465 ARG D 690
REMARK 465 SER D 691
REMARK 465 SER D 692
REMARK 465 ALA D 693
REMARK 465 ASN D 694
REMARK 465 TRP D 695
REMARK 465 GLU D 696
REMARK 465 ARG D 697
REMARK 465 LEU D 698
REMARK 465 ARG D 699
REMARK 465 GLN D 700
REMARK 465 GLY D 701
REMARK 465 THR D 702
REMARK 465 LEU D 703
REMARK 465 ARG D 704
REMARK 465 ARG D 705
REMARK 465 ASP D 706
REMARK 465 LEU D 707
REMARK 465 ARG D 708
REMARK 465 GLY D 709
REMARK 465 ILE D 710
REMARK 465 ILE D 711
REMARK 465 ASN D 712
REMARK 465 ARG D 713
REMARK 465 GLY D 714
REMARK 465 LEU D 715
REMARK 465 GLU D 716
REMARK 465 ASP D 717
REMARK 465 GLY D 718
REMARK 465 GLU D 719
REMARK 465 SER D 720
REMARK 465 TRP D 721
REMARK 465 GLU D 722
REMARK 465 TYR D 723
REMARK 465 GLN D 724
REMARK 465 ILE D 725
REMARK 465 LEU D 726
REMARK 465 VAL D 727
REMARK 465 PRO D 728
REMARK 465 ARG D 729
REMARK 465 GLY D 730
REMARK 465 SER D 731
REMARK 465 ALA D 732
REMARK 465 ALA D 733
REMARK 465 ALA D 734
REMARK 465 TRP D 735
REMARK 465 SER D 736
REMARK 465 HIS D 737
REMARK 465 PRO D 738
REMARK 465 GLN D 739
REMARK 465 PHE D 740
REMARK 465 GLU D 741
REMARK 465 LYS D 742
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 LEU A 372 CA - CB - CG ANGL. DEV. = 19.2 DEGREES
REMARK 500 LEU B 372 CA - CB - CG ANGL. DEV. = 19.2 DEGREES
REMARK 500 LEU C 372 CA - CB - CG ANGL. DEV. = 19.2 DEGREES
REMARK 500 LEU D 372 CA - CB - CG ANGL. DEV. = 19.2 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 MET A 78 17.57 -142.95
REMARK 500 TYR A 89 47.64 -93.17
REMARK 500 GLU A 113 -18.42 74.15
REMARK 500 ASN A 127 46.77 -87.25
REMARK 500 GLN A 128 -19.98 69.78
REMARK 500 ASN A 129 160.03 176.23
REMARK 500 ARG A 140 63.18 63.00
REMARK 500 PRO A 231 44.50 -85.63
REMARK 500 LEU A 232 -9.36 69.09
REMARK 500 TRP A 268 150.86 -46.76
REMARK 500 SER A 286 -165.22 -127.24
REMARK 500 GLN A 290 71.92 55.18
REMARK 500 TYR A 324 -11.73 74.79
REMARK 500 LEU A 352 70.53 55.97
REMARK 500 ASN A 358 156.04 -47.28
REMARK 500 ASN A 365 -52.36 -122.07
REMARK 500 THR A 366 56.75 -92.98
REMARK 500 LEU A 368 144.58 -172.36
REMARK 500 GLN A 369 24.26 -144.36
REMARK 500 GLN A 370 -51.45 -120.18
REMARK 500 LYS A 371 -1.37 68.09
REMARK 500 LEU A 372 86.26 59.86
REMARK 500 LEU A 373 156.88 -44.58
REMARK 500 THR A 379 83.02 60.56
REMARK 500 PRO A 380 0.34 -60.45
REMARK 500 SER A 448 -60.37 -91.04
REMARK 500 GLN A 473 131.68 -29.93
REMARK 500 MET A 474 6.25 80.60
REMARK 500 ILE A 486 -64.32 -91.04
REMARK 500 TYR A 547 -3.26 67.80
REMARK 500 CYS A 611 -2.37 73.65
REMARK 500 LEU A 612 -9.56 -143.18
REMARK 500 ARG A 621 -9.86 69.69
REMARK 500 GLN A 637 -162.25 -75.93
REMARK 500 MET B 78 17.53 -142.89
REMARK 500 TYR B 89 47.61 -93.19
REMARK 500 GLU B 113 -18.40 74.09
REMARK 500 ASN B 127 46.78 -87.23
REMARK 500 GLN B 128 -20.01 69.80
REMARK 500 ASN B 129 160.04 176.26
REMARK 500 ARG B 140 63.16 63.08
REMARK 500 PRO B 231 44.42 -85.47
REMARK 500 LEU B 232 -9.30 69.04
REMARK 500 TRP B 268 150.98 -46.86
REMARK 500 SER B 286 -165.23 -127.13
REMARK 500 GLN B 290 71.92 55.18
REMARK 500 TYR B 324 -11.78 74.80
REMARK 500 LEU B 352 70.58 55.95
REMARK 500 ASN B 358 156.08 -47.29
REMARK 500 ASN B 365 -52.35 -122.12
REMARK 500
REMARK 500 THIS ENTRY HAS 138 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 ASN A 129 MET A 130 144.37
REMARK 500 ASN B 129 MET B 130 144.35
REMARK 500 ASN C 129 MET C 130 144.34
REMARK 500 ASN D 129 MET D 130 144.35
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-7121 RELATED DB: EMDB
REMARK 900 CRYO-EM STRUCTURE OF HUMAN TRPV6 IN AMPHIPOLS
REMARK 900 RELATED ID: EMD-7122 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-7120 RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-7123 RELATED DB: EMDB
DBREF 6BO9 A 1 725 UNP Q9H1D0 TRPV6_HUMAN 41 765
DBREF 6BO9 B 1 725 UNP Q9H1D0 TRPV6_HUMAN 41 765
DBREF 6BO9 C 1 725 UNP Q9H1D0 TRPV6_HUMAN 41 765
DBREF 6BO9 D 1 725 UNP Q9H1D0 TRPV6_HUMAN 41 765
SEQADV 6BO9 LEU A 726 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 VAL A 727 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PRO A 728 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ARG A 729 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLY A 730 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 SER A 731 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA A 732 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA A 733 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA A 734 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 TRP A 735 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 SER A 736 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 HIS A 737 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PRO A 738 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLN A 739 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PHE A 740 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLU A 741 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 LYS A 742 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 LEU B 726 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 VAL B 727 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PRO B 728 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ARG B 729 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLY B 730 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 SER B 731 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA B 732 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA B 733 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA B 734 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 TRP B 735 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 SER B 736 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 HIS B 737 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PRO B 738 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLN B 739 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PHE B 740 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLU B 741 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 LYS B 742 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 LEU C 726 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 VAL C 727 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PRO C 728 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ARG C 729 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLY C 730 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 SER C 731 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA C 732 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA C 733 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA C 734 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 TRP C 735 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 SER C 736 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 HIS C 737 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PRO C 738 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLN C 739 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PHE C 740 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLU C 741 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 LYS C 742 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 LEU D 726 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 VAL D 727 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PRO D 728 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ARG D 729 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLY D 730 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 SER D 731 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA D 732 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA D 733 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 ALA D 734 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 TRP D 735 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 SER D 736 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 HIS D 737 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PRO D 738 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLN D 739 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 PHE D 740 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 GLU D 741 UNP Q9H1D0 EXPRESSION TAG
SEQADV 6BO9 LYS D 742 UNP Q9H1D0 EXPRESSION TAG
SEQRES 1 A 742 MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU
SEQRES 2 A 742 CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG
SEQRES 3 A 742 GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU
SEQRES 4 A 742 GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA
SEQRES 5 A 742 ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU
SEQRES 6 A 742 LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET
SEQRES 7 A 742 GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN
SEQRES 8 A 742 LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU
SEQRES 9 A 742 LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY
SEQRES 10 A 742 GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET
SEQRES 11 A 742 ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL
SEQRES 12 A 742 SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO
SEQRES 13 A 742 CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE
SEQRES 14 A 742 ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU
SEQRES 15 A 742 ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU
SEQRES 16 A 742 GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN
SEQRES 17 A 742 LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER
SEQRES 18 A 742 TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU
SEQRES 19 A 742 VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA
SEQRES 20 A 742 GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET
SEQRES 21 A 742 GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU
SEQRES 22 A 742 THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER
SEQRES 23 A 742 GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR
SEQRES 24 A 742 LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO
SEQRES 25 A 742 VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY
SEQRES 26 A 742 ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU
SEQRES 27 A 742 TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO
SEQRES 28 A 742 LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP
SEQRES 29 A 742 ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR
SEQRES 30 A 742 MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU
SEQRES 31 A 742 VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU
SEQRES 32 A 742 VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE
SEQRES 33 A 742 GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE
SEQRES 34 A 742 ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET
SEQRES 35 A 742 ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER
SEQRES 36 A 742 PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET TYR PHE
SEQRES 37 A 742 ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET
SEQRES 38 A 742 ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS
SEQRES 39 A 742 TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA
SEQRES 40 A 742 PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU
SEQRES 41 A 742 GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR
SEQRES 42 A 742 PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN
SEQRES 43 A 742 TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR
SEQRES 44 A 742 ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN
SEQRES 45 A 742 LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL
SEQRES 46 A 742 ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL
SEQRES 47 A 742 ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS
SEQRES 48 A 742 LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY
SEQRES 49 A 742 LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN
SEQRES 50 A 742 ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA
SEQRES 51 A 742 PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER
SEQRES 52 A 742 VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS
SEQRES 53 A 742 LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER
SEQRES 54 A 742 ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR
SEQRES 55 A 742 LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU
SEQRES 56 A 742 GLU ASP GLY GLU SER TRP GLU TYR GLN ILE LEU VAL PRO
SEQRES 57 A 742 ARG GLY SER ALA ALA ALA TRP SER HIS PRO GLN PHE GLU
SEQRES 58 A 742 LYS
SEQRES 1 B 742 MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU
SEQRES 2 B 742 CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG
SEQRES 3 B 742 GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU
SEQRES 4 B 742 GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA
SEQRES 5 B 742 ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU
SEQRES 6 B 742 LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET
SEQRES 7 B 742 GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN
SEQRES 8 B 742 LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU
SEQRES 9 B 742 LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY
SEQRES 10 B 742 GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET
SEQRES 11 B 742 ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL
SEQRES 12 B 742 SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO
SEQRES 13 B 742 CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE
SEQRES 14 B 742 ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU
SEQRES 15 B 742 ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU
SEQRES 16 B 742 GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN
SEQRES 17 B 742 LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER
SEQRES 18 B 742 TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU
SEQRES 19 B 742 VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA
SEQRES 20 B 742 GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET
SEQRES 21 B 742 GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU
SEQRES 22 B 742 THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER
SEQRES 23 B 742 GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR
SEQRES 24 B 742 LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO
SEQRES 25 B 742 VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY
SEQRES 26 B 742 ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU
SEQRES 27 B 742 TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO
SEQRES 28 B 742 LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP
SEQRES 29 B 742 ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR
SEQRES 30 B 742 MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU
SEQRES 31 B 742 VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU
SEQRES 32 B 742 VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE
SEQRES 33 B 742 GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE
SEQRES 34 B 742 ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET
SEQRES 35 B 742 ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER
SEQRES 36 B 742 PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET TYR PHE
SEQRES 37 B 742 ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET
SEQRES 38 B 742 ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS
SEQRES 39 B 742 TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA
SEQRES 40 B 742 PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU
SEQRES 41 B 742 GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR
SEQRES 42 B 742 PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN
SEQRES 43 B 742 TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR
SEQRES 44 B 742 ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN
SEQRES 45 B 742 LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL
SEQRES 46 B 742 ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL
SEQRES 47 B 742 ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS
SEQRES 48 B 742 LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY
SEQRES 49 B 742 LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN
SEQRES 50 B 742 ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA
SEQRES 51 B 742 PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER
SEQRES 52 B 742 VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS
SEQRES 53 B 742 LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER
SEQRES 54 B 742 ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR
SEQRES 55 B 742 LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU
SEQRES 56 B 742 GLU ASP GLY GLU SER TRP GLU TYR GLN ILE LEU VAL PRO
SEQRES 57 B 742 ARG GLY SER ALA ALA ALA TRP SER HIS PRO GLN PHE GLU
SEQRES 58 B 742 LYS
SEQRES 1 C 742 MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU
SEQRES 2 C 742 CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG
SEQRES 3 C 742 GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU
SEQRES 4 C 742 GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA
SEQRES 5 C 742 ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU
SEQRES 6 C 742 LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET
SEQRES 7 C 742 GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN
SEQRES 8 C 742 LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU
SEQRES 9 C 742 LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY
SEQRES 10 C 742 GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET
SEQRES 11 C 742 ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL
SEQRES 12 C 742 SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO
SEQRES 13 C 742 CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE
SEQRES 14 C 742 ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU
SEQRES 15 C 742 ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU
SEQRES 16 C 742 GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN
SEQRES 17 C 742 LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER
SEQRES 18 C 742 TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU
SEQRES 19 C 742 VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA
SEQRES 20 C 742 GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET
SEQRES 21 C 742 GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU
SEQRES 22 C 742 THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER
SEQRES 23 C 742 GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR
SEQRES 24 C 742 LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO
SEQRES 25 C 742 VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY
SEQRES 26 C 742 ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU
SEQRES 27 C 742 TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO
SEQRES 28 C 742 LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP
SEQRES 29 C 742 ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR
SEQRES 30 C 742 MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU
SEQRES 31 C 742 VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU
SEQRES 32 C 742 VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE
SEQRES 33 C 742 GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE
SEQRES 34 C 742 ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET
SEQRES 35 C 742 ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER
SEQRES 36 C 742 PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET TYR PHE
SEQRES 37 C 742 ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET
SEQRES 38 C 742 ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS
SEQRES 39 C 742 TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA
SEQRES 40 C 742 PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU
SEQRES 41 C 742 GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR
SEQRES 42 C 742 PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN
SEQRES 43 C 742 TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR
SEQRES 44 C 742 ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN
SEQRES 45 C 742 LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL
SEQRES 46 C 742 ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL
SEQRES 47 C 742 ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS
SEQRES 48 C 742 LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY
SEQRES 49 C 742 LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN
SEQRES 50 C 742 ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA
SEQRES 51 C 742 PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER
SEQRES 52 C 742 VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS
SEQRES 53 C 742 LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER
SEQRES 54 C 742 ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR
SEQRES 55 C 742 LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU
SEQRES 56 C 742 GLU ASP GLY GLU SER TRP GLU TYR GLN ILE LEU VAL PRO
SEQRES 57 C 742 ARG GLY SER ALA ALA ALA TRP SER HIS PRO GLN PHE GLU
SEQRES 58 C 742 LYS
SEQRES 1 D 742 MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU
SEQRES 2 D 742 CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG
SEQRES 3 D 742 GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU
SEQRES 4 D 742 GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA
SEQRES 5 D 742 ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU
SEQRES 6 D 742 LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET
SEQRES 7 D 742 GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN
SEQRES 8 D 742 LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU
SEQRES 9 D 742 LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY
SEQRES 10 D 742 GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET
SEQRES 11 D 742 ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL
SEQRES 12 D 742 SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO
SEQRES 13 D 742 CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE
SEQRES 14 D 742 ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU
SEQRES 15 D 742 ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU
SEQRES 16 D 742 GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN
SEQRES 17 D 742 LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER
SEQRES 18 D 742 TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU
SEQRES 19 D 742 VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA
SEQRES 20 D 742 GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET
SEQRES 21 D 742 GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU
SEQRES 22 D 742 THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER
SEQRES 23 D 742 GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR
SEQRES 24 D 742 LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO
SEQRES 25 D 742 VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY
SEQRES 26 D 742 ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU
SEQRES 27 D 742 TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO
SEQRES 28 D 742 LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP
SEQRES 29 D 742 ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR
SEQRES 30 D 742 MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU
SEQRES 31 D 742 VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU
SEQRES 32 D 742 VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE
SEQRES 33 D 742 GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE
SEQRES 34 D 742 ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET
SEQRES 35 D 742 ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER
SEQRES 36 D 742 PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET TYR PHE
SEQRES 37 D 742 ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET
SEQRES 38 D 742 ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS
SEQRES 39 D 742 TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA
SEQRES 40 D 742 PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU
SEQRES 41 D 742 GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR
SEQRES 42 D 742 PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN
SEQRES 43 D 742 TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR
SEQRES 44 D 742 ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN
SEQRES 45 D 742 LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL
SEQRES 46 D 742 ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL
SEQRES 47 D 742 ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS
SEQRES 48 D 742 LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY
SEQRES 49 D 742 LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN
SEQRES 50 D 742 ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA
SEQRES 51 D 742 PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER
SEQRES 52 D 742 VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS
SEQRES 53 D 742 LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER
SEQRES 54 D 742 ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR
SEQRES 55 D 742 LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU
SEQRES 56 D 742 GLU ASP GLY GLU SER TRP GLU TYR GLN ILE LEU VAL PRO
SEQRES 57 D 742 ARG GLY SER ALA ALA ALA TRP SER HIS PRO GLN PHE GLU
SEQRES 58 D 742 LYS
HELIX 1 AA1 TRP A 29 SER A 47 1 19
HELIX 2 AA2 SER A 47 ASP A 55 1 9
HELIX 3 AA3 ASP A 57 LYS A 66 1 10
HELIX 4 AA4 THR A 81 TYR A 89 1 9
HELIX 5 AA5 ASN A 91 ALA A 102 1 12
HELIX 6 AA6 THR A 119 ASN A 127 1 9
HELIX 7 AA7 ASN A 131 ARG A 139 1 9
HELIX 8 AA8 HIS A 165 VAL A 173 1 9
HELIX 9 AA9 SER A 175 HIS A 185 1 11
HELIX 10 AB1 THR A 198 LEU A 205 1 8
HELIX 11 AB2 LYS A 209 LEU A 220 1 12
HELIX 12 AB3 SER A 221 ARG A 224 5 4
HELIX 13 AB4 THR A 242 GLY A 251 1 10
HELIX 14 AB5 ASN A 252 LYS A 264 1 13
HELIX 15 AB6 SER A 291 THR A 299 1 9
HELIX 16 AB7 LYS A 301 ASP A 309 5 9
HELIX 17 AB8 GLN A 310 ARG A 323 1 14
HELIX 18 AB9 GLY A 325 TYR A 349 1 25
HELIX 19 AC1 PRO A 380 GLU A 403 1 24
HELIX 20 AC2 PHE A 425 SER A 446 1 22
HELIX 21 AC3 GLU A 450 ASN A 464 1 15
HELIX 22 AC4 VAL A 465 PHE A 472 5 8
HELIX 23 AC5 PRO A 477 PHE A 487 1 11
HELIX 24 AC6 PHE A 493 PHE A 512 1 20
HELIX 25 AC7 LEU A 520 TYR A 524 5 5
HELIX 26 AC8 ASP A 525 LEU A 538 1 14
HELIX 27 AC9 PRO A 552 ALA A 566 1 15
HELIX 28 AD1 LEU A 568 GLU A 588 1 21
HELIX 29 AD2 GLU A 588 ARG A 606 1 19
HELIX 30 AD3 TRP B 29 SER B 47 1 19
HELIX 31 AD4 SER B 47 ASP B 55 1 9
HELIX 32 AD5 ASP B 57 LYS B 66 1 10
HELIX 33 AD6 THR B 81 TYR B 89 1 9
HELIX 34 AD7 ASN B 91 ALA B 102 1 12
HELIX 35 AD8 THR B 119 ASN B 127 1 9
HELIX 36 AD9 ASN B 131 ARG B 139 1 9
HELIX 37 AE1 HIS B 165 VAL B 173 1 9
HELIX 38 AE2 SER B 175 HIS B 185 1 11
HELIX 39 AE3 THR B 198 LEU B 205 1 8
HELIX 40 AE4 LYS B 209 LEU B 220 1 12
HELIX 41 AE5 SER B 221 ARG B 224 5 4
HELIX 42 AE6 THR B 242 GLY B 251 1 10
HELIX 43 AE7 ASN B 252 LYS B 264 1 13
HELIX 44 AE8 SER B 291 THR B 299 1 9
HELIX 45 AE9 LYS B 301 ASP B 309 5 9
HELIX 46 AF1 GLN B 310 ARG B 323 1 14
HELIX 47 AF2 GLY B 325 TYR B 349 1 25
HELIX 48 AF3 PRO B 380 GLU B 403 1 24
HELIX 49 AF4 PHE B 425 SER B 446 1 22
HELIX 50 AF5 GLU B 450 ASN B 464 1 15
HELIX 51 AF6 VAL B 465 PHE B 472 5 8
HELIX 52 AF7 PRO B 477 PHE B 487 1 11
HELIX 53 AF8 PHE B 493 PHE B 512 1 20
HELIX 54 AF9 LEU B 520 TYR B 524 5 5
HELIX 55 AG1 ASP B 525 LEU B 538 1 14
HELIX 56 AG2 PRO B 552 ALA B 566 1 15
HELIX 57 AG3 LEU B 568 GLU B 588 1 21
HELIX 58 AG4 GLU B 588 ARG B 606 1 19
HELIX 59 AG5 TRP C 29 SER C 47 1 19
HELIX 60 AG6 SER C 47 ASP C 55 1 9
HELIX 61 AG7 ASP C 57 LYS C 66 1 10
HELIX 62 AG8 THR C 81 TYR C 89 1 9
HELIX 63 AG9 ASN C 91 ALA C 102 1 12
HELIX 64 AH1 THR C 119 ASN C 127 1 9
HELIX 65 AH2 ASN C 131 ARG C 139 1 9
HELIX 66 AH3 HIS C 165 VAL C 173 1 9
HELIX 67 AH4 SER C 175 HIS C 185 1 11
HELIX 68 AH5 THR C 198 LEU C 205 1 8
HELIX 69 AH6 LYS C 209 LEU C 220 1 12
HELIX 70 AH7 SER C 221 ARG C 224 5 4
HELIX 71 AH8 THR C 242 GLY C 251 1 10
HELIX 72 AH9 ASN C 252 LYS C 264 1 13
HELIX 73 AI1 SER C 291 THR C 299 1 9
HELIX 74 AI2 LYS C 301 ASP C 309 5 9
HELIX 75 AI3 GLN C 310 ARG C 323 1 14
HELIX 76 AI4 GLY C 325 TYR C 349 1 25
HELIX 77 AI5 PRO C 380 GLU C 403 1 24
HELIX 78 AI6 PHE C 425 SER C 446 1 22
HELIX 79 AI7 GLU C 450 ASN C 464 1 15
HELIX 80 AI8 VAL C 465 PHE C 472 5 8
HELIX 81 AI9 PRO C 477 PHE C 487 1 11
HELIX 82 AJ1 PHE C 493 PHE C 512 1 20
HELIX 83 AJ2 LEU C 520 TYR C 524 5 5
HELIX 84 AJ3 ASP C 525 LEU C 538 1 14
HELIX 85 AJ4 PRO C 552 ALA C 566 1 15
HELIX 86 AJ5 LEU C 568 GLU C 588 1 21
HELIX 87 AJ6 GLU C 588 ARG C 606 1 19
HELIX 88 AJ7 TRP D 29 SER D 47 1 19
HELIX 89 AJ8 SER D 47 ASP D 55 1 9
HELIX 90 AJ9 ASP D 57 LYS D 66 1 10
HELIX 91 AK1 THR D 81 TYR D 89 1 9
HELIX 92 AK2 ASN D 91 ALA D 102 1 12
HELIX 93 AK3 THR D 119 ASN D 127 1 9
HELIX 94 AK4 ASN D 131 ARG D 139 1 9
HELIX 95 AK5 HIS D 165 VAL D 173 1 9
HELIX 96 AK6 SER D 175 HIS D 185 1 11
HELIX 97 AK7 THR D 198 LEU D 205 1 8
HELIX 98 AK8 LYS D 209 LEU D 220 1 12
HELIX 99 AK9 SER D 221 ARG D 224 5 4
HELIX 100 AL1 THR D 242 GLY D 251 1 10
HELIX 101 AL2 ASN D 252 LYS D 264 1 13
HELIX 102 AL3 SER D 291 THR D 299 1 9
HELIX 103 AL4 LYS D 301 ASP D 309 5 9
HELIX 104 AL5 GLN D 310 ARG D 323 1 14
HELIX 105 AL6 GLY D 325 TYR D 349 1 25
HELIX 106 AL7 PRO D 380 GLU D 403 1 24
HELIX 107 AL8 PHE D 425 SER D 446 1 22
HELIX 108 AL9 GLU D 450 ASN D 464 1 15
HELIX 109 AM1 VAL D 465 PHE D 472 5 8
HELIX 110 AM2 PRO D 477 PHE D 487 1 11
HELIX 111 AM3 PHE D 493 PHE D 512 1 20
HELIX 112 AM4 LEU D 520 TYR D 524 5 5
HELIX 113 AM5 ASP D 525 LEU D 538 1 14
HELIX 114 AM6 PRO D 552 ALA D 566 1 15
HELIX 115 AM7 LEU D 568 GLU D 588 1 21
HELIX 116 AM8 GLU D 588 ARG D 606 1 19
SHEET 1 AA1 3 THR A 269 TYR A 270 0
SHEET 2 AA1 3 LEU A 273 TYR A 278 -1 O LEU A 273 N TYR A 270
SHEET 3 AA1 3 LEU A 631 GLU A 634 -1 O VAL A 633 N THR A 276
SHEET 1 AA2 3 THR B 269 TYR B 270 0
SHEET 2 AA2 3 LEU B 273 TYR B 278 -1 O LEU B 273 N TYR B 270
SHEET 3 AA2 3 LEU B 631 GLU B 634 -1 O VAL B 633 N THR B 276
SHEET 1 AA3 3 THR C 269 TYR C 270 0
SHEET 2 AA3 3 LEU C 273 TYR C 278 -1 O LEU C 273 N TYR C 270
SHEET 3 AA3 3 LEU C 631 GLU C 634 -1 O VAL C 633 N THR C 276
SHEET 1 AA4 3 THR D 269 TYR D 270 0
SHEET 2 AA4 3 LEU D 273 TYR D 278 -1 O LEU D 273 N TYR D 270
SHEET 3 AA4 3 LEU D 631 GLU D 634 -1 O VAL D 633 N THR D 276
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END