GenomeNet

Database: PDB
Entry: 6BQV
LinkDB: 6BQV
Original site: 6BQV 
HEADER    MEMBRANE PROTEIN                        28-NOV-17   6BQV              
TITLE     HUMAN TRPM4 ION CHANNEL IN LIPID NANODISCS IN A CALCIUM-BOUND STATE   
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M    
COMPND   3 MEMBER 4;                                                            
COMPND   4 CHAIN: A, B, C, D;                                                   
COMPND   5 SYNONYM: HTRPM4, CALCIUM-ACTIVATED NON-SELECTIVE CATION CHANNEL 1,   
COMPND   6 LONG TRANSIENT RECEPTOR POTENTIAL CHANNEL 4, LTRPC4, MELASTATIN-4;   
COMPND   7 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: TRPM4, LTRPC4;                                                 
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    TRPM4, TRPM CHANNEL, TRP CHANNEL, MEMBRANE PROTEIN                    
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    H.E.AUTZEN,A.G.MYASNIKOV,M.G.CAMPBELL,D.ASARNOW,D.JULIUS,Y.CHENG      
REVDAT   5   18-DEC-19 6BQV    1       REMARK                                   
REVDAT   4   22-AUG-18 6BQV    1       REMARK                                   
REVDAT   3   24-JAN-18 6BQV    1       JRNL                                     
REVDAT   2   17-JAN-18 6BQV    1       REMARK                                   
REVDAT   1   20-DEC-17 6BQV    0                                                
JRNL        AUTH   H.E.AUTZEN,A.G.MYASNIKOV,M.G.CAMPBELL,D.ASARNOW,D.JULIUS,    
JRNL        AUTH 2 Y.CHENG                                                      
JRNL        TITL   STRUCTURE OF THE HUMAN TRPM4 ION CHANNEL IN A LIPID          
JRNL        TITL 2 NANODISC.                                                    
JRNL        REF    SCIENCE                       V. 359   228 2018              
JRNL        REFN                   ESSN 1095-9203                               
JRNL        PMID   29217581                                                     
JRNL        DOI    10.1126/SCIENCE.AAR4510                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.10 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : SERIALEM, GCTF, PHENIX, CRYOSPARC,        
REMARK   3                            RELION, RELION                            
REMARK   3   RECONSTRUCTION SCHEMA  : FOURIER SPACE                             
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : AB INITIO MODEL                     
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.100                          
REMARK   3   NUMBER OF PARTICLES               : 45346                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6BQV COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 29-NOV-17.                  
REMARK 100 THE DEPOSITION ID IS D_1000231263.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : HUMAN TRPM4 ION CHANNEL           
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 2.20                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.40                              
REMARK 245   SAMPLE DETAILS                 : HUMAN TRPM4 ION CHANNEL IN        
REMARK 245  LIPID NANODISCS IN A CALCIUM-BOUND STATE                            
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 2954                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : 500.00                         
REMARK 245   MAXIMUM DEFOCUS (NM)              : 1500.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 62.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 22500                          
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     SER A    -3                                                      
REMARK 465     GLY A    -2                                                      
REMARK 465     ARG A    -1                                                      
REMARK 465     SER A     0                                                      
REMARK 465     GLY A     1                                                      
REMARK 465     VAL A     2                                                      
REMARK 465     VAL A     3                                                      
REMARK 465     PRO A     4                                                      
REMARK 465     GLU A     5                                                      
REMARK 465     LYS A     6                                                      
REMARK 465     GLU A     7                                                      
REMARK 465     GLN A     8                                                      
REMARK 465     SER A     9                                                      
REMARK 465     TRP A    10                                                      
REMARK 465     ILE A    11                                                      
REMARK 465     PRO A    12                                                      
REMARK 465     LYS A    13                                                      
REMARK 465     ILE A    14                                                      
REMARK 465     PHE A    15                                                      
REMARK 465     LYS A    16                                                      
REMARK 465     LYS A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     THR A    19                                                      
REMARK 465     CYS A    20                                                      
REMARK 465     THR A    21                                                      
REMARK 465     THR A    22                                                      
REMARK 465     PHE A    23                                                      
REMARK 465     ILE A    24                                                      
REMARK 465     VAL A    25                                                      
REMARK 465     ASP A    26                                                      
REMARK 465     SER A    27                                                      
REMARK 465     THR A    28                                                      
REMARK 465     ASP A    29                                                      
REMARK 465     PRO A    30                                                      
REMARK 465     GLY A    31                                                      
REMARK 465     GLY A    32                                                      
REMARK 465     THR A    33                                                      
REMARK 465     LEU A    34                                                      
REMARK 465     CYS A    35                                                      
REMARK 465     GLN A    36                                                      
REMARK 465     CYS A    37                                                      
REMARK 465     GLY A    38                                                      
REMARK 465     ARG A    39                                                      
REMARK 465     PRO A    40                                                      
REMARK 465     ARG A    41                                                      
REMARK 465     THR A    42                                                      
REMARK 465     ALA A    43                                                      
REMARK 465     HIS A    44                                                      
REMARK 465     PRO A    45                                                      
REMARK 465     ALA A    46                                                      
REMARK 465     VAL A    47                                                      
REMARK 465     ALA A    48                                                      
REMARK 465     MET A    49                                                      
REMARK 465     GLU A    50                                                      
REMARK 465     ASP A    51                                                      
REMARK 465     ALA A    52                                                      
REMARK 465     PHE A    53                                                      
REMARK 465     GLY A    54                                                      
REMARK 465     ALA A    55                                                      
REMARK 465     ALA A    56                                                      
REMARK 465     VAL A    57                                                      
REMARK 465     VAL A    58                                                      
REMARK 465     THR A    59                                                      
REMARK 465     VAL A    60                                                      
REMARK 465     TRP A    61                                                      
REMARK 465     ASP A    62                                                      
REMARK 465     SER A    63                                                      
REMARK 465     ASP A    64                                                      
REMARK 465     ALA A    65                                                      
REMARK 465     HIS A    66                                                      
REMARK 465     THR A    67                                                      
REMARK 465     THR A    68                                                      
REMARK 465     GLU A    69                                                      
REMARK 465     LYS A    70                                                      
REMARK 465     PRO A    71                                                      
REMARK 465     THR A    72                                                      
REMARK 465     ASP A    73                                                      
REMARK 465     ALA A    74                                                      
REMARK 465     TYR A    75                                                      
REMARK 465     GLY A    76                                                      
REMARK 465     GLU A    77                                                      
REMARK 465     LEU A    78                                                      
REMARK 465     ASP A    79                                                      
REMARK 465     PHE A    80                                                      
REMARK 465     LYS A    86                                                      
REMARK 465     ARG A   214                                                      
REMARK 465     GLY A   215                                                      
REMARK 465     ASP A   216                                                      
REMARK 465     PRO A   217                                                      
REMARK 465     GLU A   218                                                      
REMARK 465     ASP A   219                                                      
REMARK 465     GLY A   220                                                      
REMARK 465     GLY A   238                                                      
REMARK 465     THR A   239                                                      
REMARK 465     HIS A   240                                                      
REMARK 465     GLY A   241                                                      
REMARK 465     CYS A   242                                                      
REMARK 465     ALA A   320                                                      
REMARK 465     PRO A   321                                                      
REMARK 465     GLY A   322                                                      
REMARK 465     SER A   323                                                      
REMARK 465     GLY A   324                                                      
REMARK 465     GLY A   325                                                      
REMARK 465     ALA A   326                                                      
REMARK 465     ARG A   327                                                      
REMARK 465     GLN A   328                                                      
REMARK 465     SER A   387                                                      
REMARK 465     SER A   388                                                      
REMARK 465     HIS A   482                                                      
REMARK 465     SER A   483                                                      
REMARK 465     ALA A   484                                                      
REMARK 465     GLY A   485                                                      
REMARK 465     THR A   486                                                      
REMARK 465     LYS A   487                                                      
REMARK 465     ALA A   488                                                      
REMARK 465     PRO A   489                                                      
REMARK 465     ALA A   490                                                      
REMARK 465     LEU A   491                                                      
REMARK 465     LYS A   492                                                      
REMARK 465     GLY A   493                                                      
REMARK 465     GLY A   494                                                      
REMARK 465     ALA A   495                                                      
REMARK 465     ALA A   496                                                      
REMARK 465     GLU A   497                                                      
REMARK 465     LEU A   498                                                      
REMARK 465     ARG A   499                                                      
REMARK 465     PRO A   500                                                      
REMARK 465     PRO A   501                                                      
REMARK 465     ASP A   502                                                      
REMARK 465     LYS A   513                                                      
REMARK 465     MET A   514                                                      
REMARK 465     CYS A   515                                                      
REMARK 465     ALA A   516                                                      
REMARK 465     PRO A   517                                                      
REMARK 465     ARG A   518                                                      
REMARK 465     TYR A   519                                                      
REMARK 465     PRO A   520                                                      
REMARK 465     SER A   521                                                      
REMARK 465     GLY A   522                                                      
REMARK 465     GLY A   523                                                      
REMARK 465     ALA A   524                                                      
REMARK 465     TRP A   525                                                      
REMARK 465     ASP A   526                                                      
REMARK 465     PRO A   527                                                      
REMARK 465     HIS A   528                                                      
REMARK 465     PRO A   529                                                      
REMARK 465     GLY A   530                                                      
REMARK 465     GLN A   531                                                      
REMARK 465     GLY A   532                                                      
REMARK 465     PHE A   533                                                      
REMARK 465     GLY A   534                                                      
REMARK 465     GLU A   535                                                      
REMARK 465     SER A   536                                                      
REMARK 465     MET A   537                                                      
REMARK 465     TYR A   538                                                      
REMARK 465     LEU A   539                                                      
REMARK 465     LEU A   540                                                      
REMARK 465     SER A   541                                                      
REMARK 465     ASP A   542                                                      
REMARK 465     LYS A   543                                                      
REMARK 465     ALA A   544                                                      
REMARK 465     THR A   545                                                      
REMARK 465     SER A   546                                                      
REMARK 465     PRO A   547                                                      
REMARK 465     LEU A   548                                                      
REMARK 465     SER A   549                                                      
REMARK 465     LEU A   550                                                      
REMARK 465     ASP A   551                                                      
REMARK 465     ALA A   552                                                      
REMARK 465     GLY A   553                                                      
REMARK 465     LEU A   554                                                      
REMARK 465     GLY A   555                                                      
REMARK 465     GLN A   556                                                      
REMARK 465     ALA A   557                                                      
REMARK 465     LYS A   712                                                      
REMARK 465     SER A   713                                                      
REMARK 465     GLU A   714                                                      
REMARK 465     GLU A   715                                                      
REMARK 465     GLU A   716                                                      
REMARK 465     PRO A   717                                                      
REMARK 465     THR A   718                                                      
REMARK 465     ARG A   719                                                      
REMARK 465     GLU A   720                                                      
REMARK 465     GLU A   721                                                      
REMARK 465     LEU A   722                                                      
REMARK 465     GLU A   723                                                      
REMARK 465     PHE A   724                                                      
REMARK 465     ASP A   725                                                      
REMARK 465     MET A   726                                                      
REMARK 465     ASP A   727                                                      
REMARK 465     SER A   728                                                      
REMARK 465     VAL A   729                                                      
REMARK 465     ILE A   730                                                      
REMARK 465     ASN A   731                                                      
REMARK 465     GLY A   732                                                      
REMARK 465     GLU A   733                                                      
REMARK 465     GLY A   734                                                      
REMARK 465     PRO A   735                                                      
REMARK 465     VAL A   736                                                      
REMARK 465     GLY A   737                                                      
REMARK 465     THR A   738                                                      
REMARK 465     ALA A   739                                                      
REMARK 465     ASP A   740                                                      
REMARK 465     PRO A   741                                                      
REMARK 465     ALA A   742                                                      
REMARK 465     GLU A   743                                                      
REMARK 465     LYS A   744                                                      
REMARK 465     THR A   745                                                      
REMARK 465     PRO A   746                                                      
REMARK 465     LEU A   747                                                      
REMARK 465     GLY A   748                                                      
REMARK 465     VAL A   749                                                      
REMARK 465     PRO A   750                                                      
REMARK 465     ARG A   751                                                      
REMARK 465     GLN A   752                                                      
REMARK 465     SER A   753                                                      
REMARK 465     GLY A   754                                                      
REMARK 465     ARG A   755                                                      
REMARK 465     PRO A   756                                                      
REMARK 465     GLY A   757                                                      
REMARK 465     CYS A   758                                                      
REMARK 465     CYS A   759                                                      
REMARK 465     GLY A   760                                                      
REMARK 465     GLY A   761                                                      
REMARK 465     ARG A   762                                                      
REMARK 465     CYS A   763                                                      
REMARK 465     GLY A   764                                                      
REMARK 465     GLY A   765                                                      
REMARK 465     ARG A   766                                                      
REMARK 465     GLY A   836                                                      
REMARK 465     GLY A   837                                                      
REMARK 465     GLY A   838                                                      
REMARK 465     SER A   839                                                      
REMARK 465     LEU A   840                                                      
REMARK 465     ALA A   841                                                      
REMARK 465     ARG A  1095                                                      
REMARK 465     PRO A  1096                                                      
REMARK 465     ARG A  1097                                                      
REMARK 465     SER A  1098                                                      
REMARK 465     PRO A  1099                                                      
REMARK 465     GLN A  1100                                                      
REMARK 465     PRO A  1101                                                      
REMARK 465     SER A  1102                                                      
REMARK 465     SER A  1103                                                      
REMARK 465     PRO A  1104                                                      
REMARK 465     ALA A  1105                                                      
REMARK 465     LEU A  1106                                                      
REMARK 465     GLU A  1176                                                      
REMARK 465     ARG A  1177                                                      
REMARK 465     GLU A  1178                                                      
REMARK 465     VAL A  1179                                                      
REMARK 465     GLN A  1180                                                      
REMARK 465     GLN A  1181                                                      
REMARK 465     CYS A  1182                                                      
REMARK 465     SER A  1183                                                      
REMARK 465     ARG A  1184                                                      
REMARK 465     VAL A  1185                                                      
REMARK 465     LEU A  1186                                                      
REMARK 465     GLY A  1187                                                      
REMARK 465     TRP A  1188                                                      
REMARK 465     VAL A  1189                                                      
REMARK 465     ALA A  1190                                                      
REMARK 465     GLU A  1191                                                      
REMARK 465     ALA A  1192                                                      
REMARK 465     LEU A  1193                                                      
REMARK 465     SER A  1194                                                      
REMARK 465     ARG A  1195                                                      
REMARK 465     SER A  1196                                                      
REMARK 465     ALA A  1197                                                      
REMARK 465     LEU A  1198                                                      
REMARK 465     LEU A  1199                                                      
REMARK 465     PRO A  1200                                                      
REMARK 465     PRO A  1201                                                      
REMARK 465     GLY A  1202                                                      
REMARK 465     GLY A  1203                                                      
REMARK 465     PRO A  1204                                                      
REMARK 465     PRO A  1205                                                      
REMARK 465     PRO A  1206                                                      
REMARK 465     PRO A  1207                                                      
REMARK 465     ASP A  1208                                                      
REMARK 465     LEU A  1209                                                      
REMARK 465     PRO A  1210                                                      
REMARK 465     GLY A  1211                                                      
REMARK 465     SER A  1212                                                      
REMARK 465     LYS A  1213                                                      
REMARK 465     ASP A  1214                                                      
REMARK 465     SER B    -3                                                      
REMARK 465     GLY B    -2                                                      
REMARK 465     ARG B    -1                                                      
REMARK 465     SER B     0                                                      
REMARK 465     GLY B     1                                                      
REMARK 465     VAL B     2                                                      
REMARK 465     VAL B     3                                                      
REMARK 465     PRO B     4                                                      
REMARK 465     GLU B     5                                                      
REMARK 465     LYS B     6                                                      
REMARK 465     GLU B     7                                                      
REMARK 465     GLN B     8                                                      
REMARK 465     SER B     9                                                      
REMARK 465     TRP B    10                                                      
REMARK 465     ILE B    11                                                      
REMARK 465     PRO B    12                                                      
REMARK 465     LYS B    13                                                      
REMARK 465     ILE B    14                                                      
REMARK 465     PHE B    15                                                      
REMARK 465     LYS B    16                                                      
REMARK 465     LYS B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     THR B    19                                                      
REMARK 465     CYS B    20                                                      
REMARK 465     THR B    21                                                      
REMARK 465     THR B    22                                                      
REMARK 465     PHE B    23                                                      
REMARK 465     ILE B    24                                                      
REMARK 465     VAL B    25                                                      
REMARK 465     ASP B    26                                                      
REMARK 465     SER B    27                                                      
REMARK 465     THR B    28                                                      
REMARK 465     ASP B    29                                                      
REMARK 465     PRO B    30                                                      
REMARK 465     GLY B    31                                                      
REMARK 465     GLY B    32                                                      
REMARK 465     THR B    33                                                      
REMARK 465     LEU B    34                                                      
REMARK 465     CYS B    35                                                      
REMARK 465     GLN B    36                                                      
REMARK 465     CYS B    37                                                      
REMARK 465     GLY B    38                                                      
REMARK 465     ARG B    39                                                      
REMARK 465     PRO B    40                                                      
REMARK 465     ARG B    41                                                      
REMARK 465     THR B    42                                                      
REMARK 465     ALA B    43                                                      
REMARK 465     HIS B    44                                                      
REMARK 465     PRO B    45                                                      
REMARK 465     ALA B    46                                                      
REMARK 465     VAL B    47                                                      
REMARK 465     ALA B    48                                                      
REMARK 465     MET B    49                                                      
REMARK 465     GLU B    50                                                      
REMARK 465     ASP B    51                                                      
REMARK 465     ALA B    52                                                      
REMARK 465     PHE B    53                                                      
REMARK 465     GLY B    54                                                      
REMARK 465     ALA B    55                                                      
REMARK 465     ALA B    56                                                      
REMARK 465     VAL B    57                                                      
REMARK 465     VAL B    58                                                      
REMARK 465     THR B    59                                                      
REMARK 465     VAL B    60                                                      
REMARK 465     TRP B    61                                                      
REMARK 465     ASP B    62                                                      
REMARK 465     SER B    63                                                      
REMARK 465     ASP B    64                                                      
REMARK 465     ALA B    65                                                      
REMARK 465     HIS B    66                                                      
REMARK 465     THR B    67                                                      
REMARK 465     THR B    68                                                      
REMARK 465     GLU B    69                                                      
REMARK 465     LYS B    70                                                      
REMARK 465     PRO B    71                                                      
REMARK 465     THR B    72                                                      
REMARK 465     ASP B    73                                                      
REMARK 465     ALA B    74                                                      
REMARK 465     TYR B    75                                                      
REMARK 465     GLY B    76                                                      
REMARK 465     GLU B    77                                                      
REMARK 465     LEU B    78                                                      
REMARK 465     ASP B    79                                                      
REMARK 465     PHE B    80                                                      
REMARK 465     LYS B    86                                                      
REMARK 465     ARG B   214                                                      
REMARK 465     GLY B   215                                                      
REMARK 465     ASP B   216                                                      
REMARK 465     PRO B   217                                                      
REMARK 465     GLU B   218                                                      
REMARK 465     ASP B   219                                                      
REMARK 465     GLY B   220                                                      
REMARK 465     GLY B   238                                                      
REMARK 465     THR B   239                                                      
REMARK 465     HIS B   240                                                      
REMARK 465     GLY B   241                                                      
REMARK 465     CYS B   242                                                      
REMARK 465     ALA B   320                                                      
REMARK 465     PRO B   321                                                      
REMARK 465     GLY B   322                                                      
REMARK 465     SER B   323                                                      
REMARK 465     GLY B   324                                                      
REMARK 465     GLY B   325                                                      
REMARK 465     ALA B   326                                                      
REMARK 465     ARG B   327                                                      
REMARK 465     GLN B   328                                                      
REMARK 465     SER B   387                                                      
REMARK 465     SER B   388                                                      
REMARK 465     HIS B   482                                                      
REMARK 465     SER B   483                                                      
REMARK 465     ALA B   484                                                      
REMARK 465     GLY B   485                                                      
REMARK 465     THR B   486                                                      
REMARK 465     LYS B   487                                                      
REMARK 465     ALA B   488                                                      
REMARK 465     PRO B   489                                                      
REMARK 465     ALA B   490                                                      
REMARK 465     LEU B   491                                                      
REMARK 465     LYS B   492                                                      
REMARK 465     GLY B   493                                                      
REMARK 465     GLY B   494                                                      
REMARK 465     ALA B   495                                                      
REMARK 465     ALA B   496                                                      
REMARK 465     GLU B   497                                                      
REMARK 465     LEU B   498                                                      
REMARK 465     ARG B   499                                                      
REMARK 465     PRO B   500                                                      
REMARK 465     PRO B   501                                                      
REMARK 465     ASP B   502                                                      
REMARK 465     LYS B   513                                                      
REMARK 465     MET B   514                                                      
REMARK 465     CYS B   515                                                      
REMARK 465     ALA B   516                                                      
REMARK 465     PRO B   517                                                      
REMARK 465     ARG B   518                                                      
REMARK 465     TYR B   519                                                      
REMARK 465     PRO B   520                                                      
REMARK 465     SER B   521                                                      
REMARK 465     GLY B   522                                                      
REMARK 465     GLY B   523                                                      
REMARK 465     ALA B   524                                                      
REMARK 465     TRP B   525                                                      
REMARK 465     ASP B   526                                                      
REMARK 465     PRO B   527                                                      
REMARK 465     HIS B   528                                                      
REMARK 465     PRO B   529                                                      
REMARK 465     GLY B   530                                                      
REMARK 465     GLN B   531                                                      
REMARK 465     GLY B   532                                                      
REMARK 465     PHE B   533                                                      
REMARK 465     GLY B   534                                                      
REMARK 465     GLU B   535                                                      
REMARK 465     SER B   536                                                      
REMARK 465     MET B   537                                                      
REMARK 465     TYR B   538                                                      
REMARK 465     LEU B   539                                                      
REMARK 465     LEU B   540                                                      
REMARK 465     SER B   541                                                      
REMARK 465     ASP B   542                                                      
REMARK 465     LYS B   543                                                      
REMARK 465     ALA B   544                                                      
REMARK 465     THR B   545                                                      
REMARK 465     SER B   546                                                      
REMARK 465     PRO B   547                                                      
REMARK 465     LEU B   548                                                      
REMARK 465     SER B   549                                                      
REMARK 465     LEU B   550                                                      
REMARK 465     ASP B   551                                                      
REMARK 465     ALA B   552                                                      
REMARK 465     GLY B   553                                                      
REMARK 465     LEU B   554                                                      
REMARK 465     GLY B   555                                                      
REMARK 465     GLN B   556                                                      
REMARK 465     ALA B   557                                                      
REMARK 465     LYS B   712                                                      
REMARK 465     SER B   713                                                      
REMARK 465     GLU B   714                                                      
REMARK 465     GLU B   715                                                      
REMARK 465     GLU B   716                                                      
REMARK 465     PRO B   717                                                      
REMARK 465     THR B   718                                                      
REMARK 465     ARG B   719                                                      
REMARK 465     GLU B   720                                                      
REMARK 465     GLU B   721                                                      
REMARK 465     LEU B   722                                                      
REMARK 465     GLU B   723                                                      
REMARK 465     PHE B   724                                                      
REMARK 465     ASP B   725                                                      
REMARK 465     MET B   726                                                      
REMARK 465     ASP B   727                                                      
REMARK 465     SER B   728                                                      
REMARK 465     VAL B   729                                                      
REMARK 465     ILE B   730                                                      
REMARK 465     ASN B   731                                                      
REMARK 465     GLY B   732                                                      
REMARK 465     GLU B   733                                                      
REMARK 465     GLY B   734                                                      
REMARK 465     PRO B   735                                                      
REMARK 465     VAL B   736                                                      
REMARK 465     GLY B   737                                                      
REMARK 465     THR B   738                                                      
REMARK 465     ALA B   739                                                      
REMARK 465     ASP B   740                                                      
REMARK 465     PRO B   741                                                      
REMARK 465     ALA B   742                                                      
REMARK 465     GLU B   743                                                      
REMARK 465     LYS B   744                                                      
REMARK 465     THR B   745                                                      
REMARK 465     PRO B   746                                                      
REMARK 465     LEU B   747                                                      
REMARK 465     GLY B   748                                                      
REMARK 465     VAL B   749                                                      
REMARK 465     PRO B   750                                                      
REMARK 465     ARG B   751                                                      
REMARK 465     GLN B   752                                                      
REMARK 465     SER B   753                                                      
REMARK 465     GLY B   754                                                      
REMARK 465     ARG B   755                                                      
REMARK 465     PRO B   756                                                      
REMARK 465     GLY B   757                                                      
REMARK 465     CYS B   758                                                      
REMARK 465     CYS B   759                                                      
REMARK 465     GLY B   760                                                      
REMARK 465     GLY B   761                                                      
REMARK 465     ARG B   762                                                      
REMARK 465     CYS B   763                                                      
REMARK 465     GLY B   764                                                      
REMARK 465     GLY B   765                                                      
REMARK 465     ARG B   766                                                      
REMARK 465     GLY B   836                                                      
REMARK 465     GLY B   837                                                      
REMARK 465     GLY B   838                                                      
REMARK 465     SER B   839                                                      
REMARK 465     LEU B   840                                                      
REMARK 465     ALA B   841                                                      
REMARK 465     ARG B  1095                                                      
REMARK 465     PRO B  1096                                                      
REMARK 465     ARG B  1097                                                      
REMARK 465     SER B  1098                                                      
REMARK 465     PRO B  1099                                                      
REMARK 465     GLN B  1100                                                      
REMARK 465     PRO B  1101                                                      
REMARK 465     SER B  1102                                                      
REMARK 465     SER B  1103                                                      
REMARK 465     PRO B  1104                                                      
REMARK 465     ALA B  1105                                                      
REMARK 465     LEU B  1106                                                      
REMARK 465     GLU B  1176                                                      
REMARK 465     ARG B  1177                                                      
REMARK 465     GLU B  1178                                                      
REMARK 465     VAL B  1179                                                      
REMARK 465     GLN B  1180                                                      
REMARK 465     GLN B  1181                                                      
REMARK 465     CYS B  1182                                                      
REMARK 465     SER B  1183                                                      
REMARK 465     ARG B  1184                                                      
REMARK 465     VAL B  1185                                                      
REMARK 465     LEU B  1186                                                      
REMARK 465     GLY B  1187                                                      
REMARK 465     TRP B  1188                                                      
REMARK 465     VAL B  1189                                                      
REMARK 465     ALA B  1190                                                      
REMARK 465     GLU B  1191                                                      
REMARK 465     ALA B  1192                                                      
REMARK 465     LEU B  1193                                                      
REMARK 465     SER B  1194                                                      
REMARK 465     ARG B  1195                                                      
REMARK 465     SER B  1196                                                      
REMARK 465     ALA B  1197                                                      
REMARK 465     LEU B  1198                                                      
REMARK 465     LEU B  1199                                                      
REMARK 465     PRO B  1200                                                      
REMARK 465     PRO B  1201                                                      
REMARK 465     GLY B  1202                                                      
REMARK 465     GLY B  1203                                                      
REMARK 465     PRO B  1204                                                      
REMARK 465     PRO B  1205                                                      
REMARK 465     PRO B  1206                                                      
REMARK 465     PRO B  1207                                                      
REMARK 465     ASP B  1208                                                      
REMARK 465     LEU B  1209                                                      
REMARK 465     PRO B  1210                                                      
REMARK 465     GLY B  1211                                                      
REMARK 465     SER B  1212                                                      
REMARK 465     LYS B  1213                                                      
REMARK 465     ASP B  1214                                                      
REMARK 465     SER C    -3                                                      
REMARK 465     GLY C    -2                                                      
REMARK 465     ARG C    -1                                                      
REMARK 465     SER C     0                                                      
REMARK 465     GLY C     1                                                      
REMARK 465     VAL C     2                                                      
REMARK 465     VAL C     3                                                      
REMARK 465     PRO C     4                                                      
REMARK 465     GLU C     5                                                      
REMARK 465     LYS C     6                                                      
REMARK 465     GLU C     7                                                      
REMARK 465     GLN C     8                                                      
REMARK 465     SER C     9                                                      
REMARK 465     TRP C    10                                                      
REMARK 465     ILE C    11                                                      
REMARK 465     PRO C    12                                                      
REMARK 465     LYS C    13                                                      
REMARK 465     ILE C    14                                                      
REMARK 465     PHE C    15                                                      
REMARK 465     LYS C    16                                                      
REMARK 465     LYS C    17                                                      
REMARK 465     LYS C    18                                                      
REMARK 465     THR C    19                                                      
REMARK 465     CYS C    20                                                      
REMARK 465     THR C    21                                                      
REMARK 465     THR C    22                                                      
REMARK 465     PHE C    23                                                      
REMARK 465     ILE C    24                                                      
REMARK 465     VAL C    25                                                      
REMARK 465     ASP C    26                                                      
REMARK 465     SER C    27                                                      
REMARK 465     THR C    28                                                      
REMARK 465     ASP C    29                                                      
REMARK 465     PRO C    30                                                      
REMARK 465     GLY C    31                                                      
REMARK 465     GLY C    32                                                      
REMARK 465     THR C    33                                                      
REMARK 465     LEU C    34                                                      
REMARK 465     CYS C    35                                                      
REMARK 465     GLN C    36                                                      
REMARK 465     CYS C    37                                                      
REMARK 465     GLY C    38                                                      
REMARK 465     ARG C    39                                                      
REMARK 465     PRO C    40                                                      
REMARK 465     ARG C    41                                                      
REMARK 465     THR C    42                                                      
REMARK 465     ALA C    43                                                      
REMARK 465     HIS C    44                                                      
REMARK 465     PRO C    45                                                      
REMARK 465     ALA C    46                                                      
REMARK 465     VAL C    47                                                      
REMARK 465     ALA C    48                                                      
REMARK 465     MET C    49                                                      
REMARK 465     GLU C    50                                                      
REMARK 465     ASP C    51                                                      
REMARK 465     ALA C    52                                                      
REMARK 465     PHE C    53                                                      
REMARK 465     GLY C    54                                                      
REMARK 465     ALA C    55                                                      
REMARK 465     ALA C    56                                                      
REMARK 465     VAL C    57                                                      
REMARK 465     VAL C    58                                                      
REMARK 465     THR C    59                                                      
REMARK 465     VAL C    60                                                      
REMARK 465     TRP C    61                                                      
REMARK 465     ASP C    62                                                      
REMARK 465     SER C    63                                                      
REMARK 465     ASP C    64                                                      
REMARK 465     ALA C    65                                                      
REMARK 465     HIS C    66                                                      
REMARK 465     THR C    67                                                      
REMARK 465     THR C    68                                                      
REMARK 465     GLU C    69                                                      
REMARK 465     LYS C    70                                                      
REMARK 465     PRO C    71                                                      
REMARK 465     THR C    72                                                      
REMARK 465     ASP C    73                                                      
REMARK 465     ALA C    74                                                      
REMARK 465     TYR C    75                                                      
REMARK 465     GLY C    76                                                      
REMARK 465     GLU C    77                                                      
REMARK 465     LEU C    78                                                      
REMARK 465     ASP C    79                                                      
REMARK 465     PHE C    80                                                      
REMARK 465     LYS C    86                                                      
REMARK 465     ARG C   214                                                      
REMARK 465     GLY C   215                                                      
REMARK 465     ASP C   216                                                      
REMARK 465     PRO C   217                                                      
REMARK 465     GLU C   218                                                      
REMARK 465     ASP C   219                                                      
REMARK 465     GLY C   220                                                      
REMARK 465     GLY C   238                                                      
REMARK 465     THR C   239                                                      
REMARK 465     HIS C   240                                                      
REMARK 465     GLY C   241                                                      
REMARK 465     CYS C   242                                                      
REMARK 465     ALA C   320                                                      
REMARK 465     PRO C   321                                                      
REMARK 465     GLY C   322                                                      
REMARK 465     SER C   323                                                      
REMARK 465     GLY C   324                                                      
REMARK 465     GLY C   325                                                      
REMARK 465     ALA C   326                                                      
REMARK 465     ARG C   327                                                      
REMARK 465     GLN C   328                                                      
REMARK 465     SER C   387                                                      
REMARK 465     SER C   388                                                      
REMARK 465     HIS C   482                                                      
REMARK 465     SER C   483                                                      
REMARK 465     ALA C   484                                                      
REMARK 465     GLY C   485                                                      
REMARK 465     THR C   486                                                      
REMARK 465     LYS C   487                                                      
REMARK 465     ALA C   488                                                      
REMARK 465     PRO C   489                                                      
REMARK 465     ALA C   490                                                      
REMARK 465     LEU C   491                                                      
REMARK 465     LYS C   492                                                      
REMARK 465     GLY C   493                                                      
REMARK 465     GLY C   494                                                      
REMARK 465     ALA C   495                                                      
REMARK 465     ALA C   496                                                      
REMARK 465     GLU C   497                                                      
REMARK 465     LEU C   498                                                      
REMARK 465     ARG C   499                                                      
REMARK 465     PRO C   500                                                      
REMARK 465     PRO C   501                                                      
REMARK 465     ASP C   502                                                      
REMARK 465     LYS C   513                                                      
REMARK 465     MET C   514                                                      
REMARK 465     CYS C   515                                                      
REMARK 465     ALA C   516                                                      
REMARK 465     PRO C   517                                                      
REMARK 465     ARG C   518                                                      
REMARK 465     TYR C   519                                                      
REMARK 465     PRO C   520                                                      
REMARK 465     SER C   521                                                      
REMARK 465     GLY C   522                                                      
REMARK 465     GLY C   523                                                      
REMARK 465     ALA C   524                                                      
REMARK 465     TRP C   525                                                      
REMARK 465     ASP C   526                                                      
REMARK 465     PRO C   527                                                      
REMARK 465     HIS C   528                                                      
REMARK 465     PRO C   529                                                      
REMARK 465     GLY C   530                                                      
REMARK 465     GLN C   531                                                      
REMARK 465     GLY C   532                                                      
REMARK 465     PHE C   533                                                      
REMARK 465     GLY C   534                                                      
REMARK 465     GLU C   535                                                      
REMARK 465     SER C   536                                                      
REMARK 465     MET C   537                                                      
REMARK 465     TYR C   538                                                      
REMARK 465     LEU C   539                                                      
REMARK 465     LEU C   540                                                      
REMARK 465     SER C   541                                                      
REMARK 465     ASP C   542                                                      
REMARK 465     LYS C   543                                                      
REMARK 465     ALA C   544                                                      
REMARK 465     THR C   545                                                      
REMARK 465     SER C   546                                                      
REMARK 465     PRO C   547                                                      
REMARK 465     LEU C   548                                                      
REMARK 465     SER C   549                                                      
REMARK 465     LEU C   550                                                      
REMARK 465     ASP C   551                                                      
REMARK 465     ALA C   552                                                      
REMARK 465     GLY C   553                                                      
REMARK 465     LEU C   554                                                      
REMARK 465     GLY C   555                                                      
REMARK 465     GLN C   556                                                      
REMARK 465     ALA C   557                                                      
REMARK 465     LYS C   712                                                      
REMARK 465     SER C   713                                                      
REMARK 465     GLU C   714                                                      
REMARK 465     GLU C   715                                                      
REMARK 465     GLU C   716                                                      
REMARK 465     PRO C   717                                                      
REMARK 465     THR C   718                                                      
REMARK 465     ARG C   719                                                      
REMARK 465     GLU C   720                                                      
REMARK 465     GLU C   721                                                      
REMARK 465     LEU C   722                                                      
REMARK 465     GLU C   723                                                      
REMARK 465     PHE C   724                                                      
REMARK 465     ASP C   725                                                      
REMARK 465     MET C   726                                                      
REMARK 465     ASP C   727                                                      
REMARK 465     SER C   728                                                      
REMARK 465     VAL C   729                                                      
REMARK 465     ILE C   730                                                      
REMARK 465     ASN C   731                                                      
REMARK 465     GLY C   732                                                      
REMARK 465     GLU C   733                                                      
REMARK 465     GLY C   734                                                      
REMARK 465     PRO C   735                                                      
REMARK 465     VAL C   736                                                      
REMARK 465     GLY C   737                                                      
REMARK 465     THR C   738                                                      
REMARK 465     ALA C   739                                                      
REMARK 465     ASP C   740                                                      
REMARK 465     PRO C   741                                                      
REMARK 465     ALA C   742                                                      
REMARK 465     GLU C   743                                                      
REMARK 465     LYS C   744                                                      
REMARK 465     THR C   745                                                      
REMARK 465     PRO C   746                                                      
REMARK 465     LEU C   747                                                      
REMARK 465     GLY C   748                                                      
REMARK 465     VAL C   749                                                      
REMARK 465     PRO C   750                                                      
REMARK 465     ARG C   751                                                      
REMARK 465     GLN C   752                                                      
REMARK 465     SER C   753                                                      
REMARK 465     GLY C   754                                                      
REMARK 465     ARG C   755                                                      
REMARK 465     PRO C   756                                                      
REMARK 465     GLY C   757                                                      
REMARK 465     CYS C   758                                                      
REMARK 465     CYS C   759                                                      
REMARK 465     GLY C   760                                                      
REMARK 465     GLY C   761                                                      
REMARK 465     ARG C   762                                                      
REMARK 465     CYS C   763                                                      
REMARK 465     GLY C   764                                                      
REMARK 465     GLY C   765                                                      
REMARK 465     ARG C   766                                                      
REMARK 465     GLY C   836                                                      
REMARK 465     GLY C   837                                                      
REMARK 465     GLY C   838                                                      
REMARK 465     SER C   839                                                      
REMARK 465     LEU C   840                                                      
REMARK 465     ALA C   841                                                      
REMARK 465     ARG C  1095                                                      
REMARK 465     PRO C  1096                                                      
REMARK 465     ARG C  1097                                                      
REMARK 465     SER C  1098                                                      
REMARK 465     PRO C  1099                                                      
REMARK 465     GLN C  1100                                                      
REMARK 465     PRO C  1101                                                      
REMARK 465     SER C  1102                                                      
REMARK 465     SER C  1103                                                      
REMARK 465     PRO C  1104                                                      
REMARK 465     ALA C  1105                                                      
REMARK 465     LEU C  1106                                                      
REMARK 465     GLU C  1176                                                      
REMARK 465     ARG C  1177                                                      
REMARK 465     GLU C  1178                                                      
REMARK 465     VAL C  1179                                                      
REMARK 465     GLN C  1180                                                      
REMARK 465     GLN C  1181                                                      
REMARK 465     CYS C  1182                                                      
REMARK 465     SER C  1183                                                      
REMARK 465     ARG C  1184                                                      
REMARK 465     VAL C  1185                                                      
REMARK 465     LEU C  1186                                                      
REMARK 465     GLY C  1187                                                      
REMARK 465     TRP C  1188                                                      
REMARK 465     VAL C  1189                                                      
REMARK 465     ALA C  1190                                                      
REMARK 465     GLU C  1191                                                      
REMARK 465     ALA C  1192                                                      
REMARK 465     LEU C  1193                                                      
REMARK 465     SER C  1194                                                      
REMARK 465     ARG C  1195                                                      
REMARK 465     SER C  1196                                                      
REMARK 465     ALA C  1197                                                      
REMARK 465     LEU C  1198                                                      
REMARK 465     LEU C  1199                                                      
REMARK 465     PRO C  1200                                                      
REMARK 465     PRO C  1201                                                      
REMARK 465     GLY C  1202                                                      
REMARK 465     GLY C  1203                                                      
REMARK 465     PRO C  1204                                                      
REMARK 465     PRO C  1205                                                      
REMARK 465     PRO C  1206                                                      
REMARK 465     PRO C  1207                                                      
REMARK 465     ASP C  1208                                                      
REMARK 465     LEU C  1209                                                      
REMARK 465     PRO C  1210                                                      
REMARK 465     GLY C  1211                                                      
REMARK 465     SER C  1212                                                      
REMARK 465     LYS C  1213                                                      
REMARK 465     ASP C  1214                                                      
REMARK 465     SER D    -3                                                      
REMARK 465     GLY D    -2                                                      
REMARK 465     ARG D    -1                                                      
REMARK 465     SER D     0                                                      
REMARK 465     GLY D     1                                                      
REMARK 465     VAL D     2                                                      
REMARK 465     VAL D     3                                                      
REMARK 465     PRO D     4                                                      
REMARK 465     GLU D     5                                                      
REMARK 465     LYS D     6                                                      
REMARK 465     GLU D     7                                                      
REMARK 465     GLN D     8                                                      
REMARK 465     SER D     9                                                      
REMARK 465     TRP D    10                                                      
REMARK 465     ILE D    11                                                      
REMARK 465     PRO D    12                                                      
REMARK 465     LYS D    13                                                      
REMARK 465     ILE D    14                                                      
REMARK 465     PHE D    15                                                      
REMARK 465     LYS D    16                                                      
REMARK 465     LYS D    17                                                      
REMARK 465     LYS D    18                                                      
REMARK 465     THR D    19                                                      
REMARK 465     CYS D    20                                                      
REMARK 465     THR D    21                                                      
REMARK 465     THR D    22                                                      
REMARK 465     PHE D    23                                                      
REMARK 465     ILE D    24                                                      
REMARK 465     VAL D    25                                                      
REMARK 465     ASP D    26                                                      
REMARK 465     SER D    27                                                      
REMARK 465     THR D    28                                                      
REMARK 465     ASP D    29                                                      
REMARK 465     PRO D    30                                                      
REMARK 465     GLY D    31                                                      
REMARK 465     GLY D    32                                                      
REMARK 465     THR D    33                                                      
REMARK 465     LEU D    34                                                      
REMARK 465     CYS D    35                                                      
REMARK 465     GLN D    36                                                      
REMARK 465     CYS D    37                                                      
REMARK 465     GLY D    38                                                      
REMARK 465     ARG D    39                                                      
REMARK 465     PRO D    40                                                      
REMARK 465     ARG D    41                                                      
REMARK 465     THR D    42                                                      
REMARK 465     ALA D    43                                                      
REMARK 465     HIS D    44                                                      
REMARK 465     PRO D    45                                                      
REMARK 465     ALA D    46                                                      
REMARK 465     VAL D    47                                                      
REMARK 465     ALA D    48                                                      
REMARK 465     MET D    49                                                      
REMARK 465     GLU D    50                                                      
REMARK 465     ASP D    51                                                      
REMARK 465     ALA D    52                                                      
REMARK 465     PHE D    53                                                      
REMARK 465     GLY D    54                                                      
REMARK 465     ALA D    55                                                      
REMARK 465     ALA D    56                                                      
REMARK 465     VAL D    57                                                      
REMARK 465     VAL D    58                                                      
REMARK 465     THR D    59                                                      
REMARK 465     VAL D    60                                                      
REMARK 465     TRP D    61                                                      
REMARK 465     ASP D    62                                                      
REMARK 465     SER D    63                                                      
REMARK 465     ASP D    64                                                      
REMARK 465     ALA D    65                                                      
REMARK 465     HIS D    66                                                      
REMARK 465     THR D    67                                                      
REMARK 465     THR D    68                                                      
REMARK 465     GLU D    69                                                      
REMARK 465     LYS D    70                                                      
REMARK 465     PRO D    71                                                      
REMARK 465     THR D    72                                                      
REMARK 465     ASP D    73                                                      
REMARK 465     ALA D    74                                                      
REMARK 465     TYR D    75                                                      
REMARK 465     GLY D    76                                                      
REMARK 465     GLU D    77                                                      
REMARK 465     LEU D    78                                                      
REMARK 465     ASP D    79                                                      
REMARK 465     PHE D    80                                                      
REMARK 465     LYS D    86                                                      
REMARK 465     ARG D   214                                                      
REMARK 465     GLY D   215                                                      
REMARK 465     ASP D   216                                                      
REMARK 465     PRO D   217                                                      
REMARK 465     GLU D   218                                                      
REMARK 465     ASP D   219                                                      
REMARK 465     GLY D   220                                                      
REMARK 465     GLY D   238                                                      
REMARK 465     THR D   239                                                      
REMARK 465     HIS D   240                                                      
REMARK 465     GLY D   241                                                      
REMARK 465     CYS D   242                                                      
REMARK 465     ALA D   320                                                      
REMARK 465     PRO D   321                                                      
REMARK 465     GLY D   322                                                      
REMARK 465     SER D   323                                                      
REMARK 465     GLY D   324                                                      
REMARK 465     GLY D   325                                                      
REMARK 465     ALA D   326                                                      
REMARK 465     ARG D   327                                                      
REMARK 465     GLN D   328                                                      
REMARK 465     SER D   387                                                      
REMARK 465     SER D   388                                                      
REMARK 465     HIS D   482                                                      
REMARK 465     SER D   483                                                      
REMARK 465     ALA D   484                                                      
REMARK 465     GLY D   485                                                      
REMARK 465     THR D   486                                                      
REMARK 465     LYS D   487                                                      
REMARK 465     ALA D   488                                                      
REMARK 465     PRO D   489                                                      
REMARK 465     ALA D   490                                                      
REMARK 465     LEU D   491                                                      
REMARK 465     LYS D   492                                                      
REMARK 465     GLY D   493                                                      
REMARK 465     GLY D   494                                                      
REMARK 465     ALA D   495                                                      
REMARK 465     ALA D   496                                                      
REMARK 465     GLU D   497                                                      
REMARK 465     LEU D   498                                                      
REMARK 465     ARG D   499                                                      
REMARK 465     PRO D   500                                                      
REMARK 465     PRO D   501                                                      
REMARK 465     ASP D   502                                                      
REMARK 465     LYS D   513                                                      
REMARK 465     MET D   514                                                      
REMARK 465     CYS D   515                                                      
REMARK 465     ALA D   516                                                      
REMARK 465     PRO D   517                                                      
REMARK 465     ARG D   518                                                      
REMARK 465     TYR D   519                                                      
REMARK 465     PRO D   520                                                      
REMARK 465     SER D   521                                                      
REMARK 465     GLY D   522                                                      
REMARK 465     GLY D   523                                                      
REMARK 465     ALA D   524                                                      
REMARK 465     TRP D   525                                                      
REMARK 465     ASP D   526                                                      
REMARK 465     PRO D   527                                                      
REMARK 465     HIS D   528                                                      
REMARK 465     PRO D   529                                                      
REMARK 465     GLY D   530                                                      
REMARK 465     GLN D   531                                                      
REMARK 465     GLY D   532                                                      
REMARK 465     PHE D   533                                                      
REMARK 465     GLY D   534                                                      
REMARK 465     GLU D   535                                                      
REMARK 465     SER D   536                                                      
REMARK 465     MET D   537                                                      
REMARK 465     TYR D   538                                                      
REMARK 465     LEU D   539                                                      
REMARK 465     LEU D   540                                                      
REMARK 465     SER D   541                                                      
REMARK 465     ASP D   542                                                      
REMARK 465     LYS D   543                                                      
REMARK 465     ALA D   544                                                      
REMARK 465     THR D   545                                                      
REMARK 465     SER D   546                                                      
REMARK 465     PRO D   547                                                      
REMARK 465     LEU D   548                                                      
REMARK 465     SER D   549                                                      
REMARK 465     LEU D   550                                                      
REMARK 465     ASP D   551                                                      
REMARK 465     ALA D   552                                                      
REMARK 465     GLY D   553                                                      
REMARK 465     LEU D   554                                                      
REMARK 465     GLY D   555                                                      
REMARK 465     GLN D   556                                                      
REMARK 465     ALA D   557                                                      
REMARK 465     LYS D   712                                                      
REMARK 465     SER D   713                                                      
REMARK 465     GLU D   714                                                      
REMARK 465     GLU D   715                                                      
REMARK 465     GLU D   716                                                      
REMARK 465     PRO D   717                                                      
REMARK 465     THR D   718                                                      
REMARK 465     ARG D   719                                                      
REMARK 465     GLU D   720                                                      
REMARK 465     GLU D   721                                                      
REMARK 465     LEU D   722                                                      
REMARK 465     GLU D   723                                                      
REMARK 465     PHE D   724                                                      
REMARK 465     ASP D   725                                                      
REMARK 465     MET D   726                                                      
REMARK 465     ASP D   727                                                      
REMARK 465     SER D   728                                                      
REMARK 465     VAL D   729                                                      
REMARK 465     ILE D   730                                                      
REMARK 465     ASN D   731                                                      
REMARK 465     GLY D   732                                                      
REMARK 465     GLU D   733                                                      
REMARK 465     GLY D   734                                                      
REMARK 465     PRO D   735                                                      
REMARK 465     VAL D   736                                                      
REMARK 465     GLY D   737                                                      
REMARK 465     THR D   738                                                      
REMARK 465     ALA D   739                                                      
REMARK 465     ASP D   740                                                      
REMARK 465     PRO D   741                                                      
REMARK 465     ALA D   742                                                      
REMARK 465     GLU D   743                                                      
REMARK 465     LYS D   744                                                      
REMARK 465     THR D   745                                                      
REMARK 465     PRO D   746                                                      
REMARK 465     LEU D   747                                                      
REMARK 465     GLY D   748                                                      
REMARK 465     VAL D   749                                                      
REMARK 465     PRO D   750                                                      
REMARK 465     ARG D   751                                                      
REMARK 465     GLN D   752                                                      
REMARK 465     SER D   753                                                      
REMARK 465     GLY D   754                                                      
REMARK 465     ARG D   755                                                      
REMARK 465     PRO D   756                                                      
REMARK 465     GLY D   757                                                      
REMARK 465     CYS D   758                                                      
REMARK 465     CYS D   759                                                      
REMARK 465     GLY D   760                                                      
REMARK 465     GLY D   761                                                      
REMARK 465     ARG D   762                                                      
REMARK 465     CYS D   763                                                      
REMARK 465     GLY D   764                                                      
REMARK 465     GLY D   765                                                      
REMARK 465     ARG D   766                                                      
REMARK 465     GLY D   836                                                      
REMARK 465     GLY D   837                                                      
REMARK 465     GLY D   838                                                      
REMARK 465     SER D   839                                                      
REMARK 465     LEU D   840                                                      
REMARK 465     ALA D   841                                                      
REMARK 465     ARG D  1095                                                      
REMARK 465     PRO D  1096                                                      
REMARK 465     ARG D  1097                                                      
REMARK 465     SER D  1098                                                      
REMARK 465     PRO D  1099                                                      
REMARK 465     GLN D  1100                                                      
REMARK 465     PRO D  1101                                                      
REMARK 465     SER D  1102                                                      
REMARK 465     SER D  1103                                                      
REMARK 465     PRO D  1104                                                      
REMARK 465     ALA D  1105                                                      
REMARK 465     LEU D  1106                                                      
REMARK 465     GLU D  1176                                                      
REMARK 465     ARG D  1177                                                      
REMARK 465     GLU D  1178                                                      
REMARK 465     VAL D  1179                                                      
REMARK 465     GLN D  1180                                                      
REMARK 465     GLN D  1181                                                      
REMARK 465     CYS D  1182                                                      
REMARK 465     SER D  1183                                                      
REMARK 465     ARG D  1184                                                      
REMARK 465     VAL D  1185                                                      
REMARK 465     LEU D  1186                                                      
REMARK 465     GLY D  1187                                                      
REMARK 465     TRP D  1188                                                      
REMARK 465     VAL D  1189                                                      
REMARK 465     ALA D  1190                                                      
REMARK 465     GLU D  1191                                                      
REMARK 465     ALA D  1192                                                      
REMARK 465     LEU D  1193                                                      
REMARK 465     SER D  1194                                                      
REMARK 465     ARG D  1195                                                      
REMARK 465     SER D  1196                                                      
REMARK 465     ALA D  1197                                                      
REMARK 465     LEU D  1198                                                      
REMARK 465     LEU D  1199                                                      
REMARK 465     PRO D  1200                                                      
REMARK 465     PRO D  1201                                                      
REMARK 465     GLY D  1202                                                      
REMARK 465     GLY D  1203                                                      
REMARK 465     PRO D  1204                                                      
REMARK 465     PRO D  1205                                                      
REMARK 465     PRO D  1206                                                      
REMARK 465     PRO D  1207                                                      
REMARK 465     ASP D  1208                                                      
REMARK 465     LEU D  1209                                                      
REMARK 465     PRO D  1210                                                      
REMARK 465     GLY D  1211                                                      
REMARK 465     SER D  1212                                                      
REMARK 465     LYS D  1213                                                      
REMARK 465     ASP D  1214                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ARG A  85    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS A  87    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU A 158    CG   CD1  CD2                                       
REMARK 470     VAL A 194    CG1  CG2                                            
REMARK 470     LEU A 200    CG   CD1  CD2                                       
REMARK 470     ILE A 201    CG1  CG2  CD1                                       
REMARK 470     ASN A 202    CG   OD1  ND2                                       
REMARK 470     LYS A 204    CG   CD   CE   NZ                                   
REMARK 470     SER A 206    OG                                                  
REMARK 470     PHE A 207    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG A 210    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP A 236    CG   OD1  OD2                                       
REMARK 470     GLU A 389    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 664    NH1  NH2                                            
REMARK 470     THR A 688    CG2                                                 
REMARK 470     ILE A 690    CG2                                                 
REMARK 470     LEU A 695    CG   CD1  CD2                                       
REMARK 470     LEU A 702    CD1  CD2                                            
REMARK 470     ILE A 703    CG2                                                 
REMARK 470     ARG A 706    NH1  NH2                                            
REMARK 470     SER A 842    OG                                                  
REMARK 470     HIS A 849    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU A1107    CG   CD   OE1  OE2                                  
REMARK 470     HIS A1108    CG   ND1  CD2  CE1  NE2                             
REMARK 470     PHE A1109    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG A1110    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B  85    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS B  87    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU B 158    CG   CD1  CD2                                       
REMARK 470     VAL B 194    CG1  CG2                                            
REMARK 470     LEU B 200    CG   CD1  CD2                                       
REMARK 470     ILE B 201    CG1  CG2  CD1                                       
REMARK 470     ASN B 202    CG   OD1  ND2                                       
REMARK 470     LYS B 204    CG   CD   CE   NZ                                   
REMARK 470     SER B 206    OG                                                  
REMARK 470     PHE B 207    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG B 210    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B 236    CG   OD1  OD2                                       
REMARK 470     GLU B 389    CG   CD   OE1  OE2                                  
REMARK 470     ARG B 664    NH1  NH2                                            
REMARK 470     THR B 688    CG2                                                 
REMARK 470     ILE B 690    CG2                                                 
REMARK 470     LEU B 695    CG   CD1  CD2                                       
REMARK 470     LEU B 702    CD1  CD2                                            
REMARK 470     ILE B 703    CG2                                                 
REMARK 470     ARG B 706    NH1  NH2                                            
REMARK 470     SER B 842    OG                                                  
REMARK 470     HIS B 849    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU B1107    CG   CD   OE1  OE2                                  
REMARK 470     HIS B1108    CG   ND1  CD2  CE1  NE2                             
REMARK 470     PHE B1109    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG B1110    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C  85    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS C  87    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU C 158    CG   CD1  CD2                                       
REMARK 470     VAL C 194    CG1  CG2                                            
REMARK 470     LEU C 200    CG   CD1  CD2                                       
REMARK 470     ILE C 201    CG1  CG2  CD1                                       
REMARK 470     ASN C 202    CG   OD1  ND2                                       
REMARK 470     LYS C 204    CG   CD   CE   NZ                                   
REMARK 470     SER C 206    OG                                                  
REMARK 470     PHE C 207    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG C 210    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP C 236    CG   OD1  OD2                                       
REMARK 470     GLU C 389    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 664    NH1  NH2                                            
REMARK 470     THR C 688    CG2                                                 
REMARK 470     ILE C 690    CG2                                                 
REMARK 470     LEU C 695    CG   CD1  CD2                                       
REMARK 470     LEU C 702    CD1  CD2                                            
REMARK 470     ILE C 703    CG2                                                 
REMARK 470     ARG C 706    NH1  NH2                                            
REMARK 470     SER C 842    OG                                                  
REMARK 470     HIS C 849    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU C1107    CG   CD   OE1  OE2                                  
REMARK 470     HIS C1108    CG   ND1  CD2  CE1  NE2                             
REMARK 470     PHE C1109    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG C1110    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG D  85    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS D  87    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU D 158    CG   CD1  CD2                                       
REMARK 470     VAL D 194    CG1  CG2                                            
REMARK 470     LEU D 200    CG   CD1  CD2                                       
REMARK 470     ILE D 201    CG1  CG2  CD1                                       
REMARK 470     ASN D 202    CG   OD1  ND2                                       
REMARK 470     LYS D 204    CG   CD   CE   NZ                                   
REMARK 470     SER D 206    OG                                                  
REMARK 470     PHE D 207    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG D 210    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP D 236    CG   OD1  OD2                                       
REMARK 470     GLU D 389    CG   CD   OE1  OE2                                  
REMARK 470     ARG D 664    NH1  NH2                                            
REMARK 470     THR D 688    CG2                                                 
REMARK 470     ILE D 690    CG2                                                 
REMARK 470     LEU D 695    CG   CD1  CD2                                       
REMARK 470     LEU D 702    CD1  CD2                                            
REMARK 470     ILE D 703    CG2                                                 
REMARK 470     ARG D 706    NH1  NH2                                            
REMARK 470     SER D 842    OG                                                  
REMARK 470     HIS D 849    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU D1107    CG   CD   OE1  OE2                                  
REMARK 470     HIS D1108    CG   ND1  CD2  CE1  NE2                             
REMARK 470     PHE D1109    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG D1110    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   NH2  ARG B  1166     CG   HIS D  1164              1.22            
REMARK 500   CG   HIS A  1164     NH2  ARG C  1166              1.26            
REMARK 500   CG   HIS C  1164     NH2  ARG D  1166              1.32            
REMARK 500   NH2  ARG A  1166     CG   HIS B  1164              1.35            
REMARK 500   OD2  ASP B   172     CZ   PHE D   414              1.46            
REMARK 500   CZ   PHE A   414     OD2  ASP C   172              1.48            
REMARK 500   CD1  LEU A   472     CD   PRO A   604              1.48            
REMARK 500   CD1  LEU B   472     CD   PRO B   604              1.48            
REMARK 500   CD1  LEU C   472     CD   PRO C   604              1.48            
REMARK 500   CD1  LEU D   472     CD   PRO D   604              1.48            
REMARK 500   CZ   PHE C   414     OD2  ASP D   172              1.52            
REMARK 500   OD2  ASP A   172     CZ   PHE B   414              1.54            
REMARK 500   O    ASP B   172     CE1  PHE D   414              1.58            
REMARK 500   CE1  PHE A   414     O    ASP C   172              1.59            
REMARK 500   CD1  LEU B   463     CE2  TRP B   565              1.63            
REMARK 500   CD1  LEU C   463     CE2  TRP C   565              1.63            
REMARK 500   CD1  LEU D   463     CE2  TRP D   565              1.63            
REMARK 500   CD1  LEU A   463     CE2  TRP A   565              1.63            
REMARK 500   NH2  ARG B  1166     ND1  HIS D  1164              1.63            
REMARK 500   CE1  PHE C   414     O    ASP D   172              1.65            
REMARK 500   ND1  HIS A  1164     NH2  ARG C  1166              1.66            
REMARK 500   O    ASP A   172     CE1  PHE B   414              1.67            
REMARK 500   ND1  HIS C  1164     NH2  ARG D  1166              1.71            
REMARK 500   NH2  ARG A  1166     ND1  HIS B  1164              1.74            
REMARK 500   NH2  ARG B  1166     CD2  HIS D  1164              1.79            
REMARK 500   CD2  HIS A  1164     NH2  ARG C  1166              1.83            
REMARK 500   NH2  ARG A  1166     CD2  HIS B  1164              1.85            
REMARK 500   CD2  HIS C  1164     NH2  ARG D  1166              1.85            
REMARK 500   OD1  ASP B   172     O    PHE D   414              1.89            
REMARK 500   CD1  LEU A   463     NE1  TRP A   565              1.89            
REMARK 500   CD1  LEU D   463     NE1  TRP D   565              1.89            
REMARK 500   CD1  LEU B   463     NE1  TRP B   565              1.89            
REMARK 500   CD1  LEU C   463     NE1  TRP C   565              1.89            
REMARK 500   OD1  ASP A   172     O    PHE B   414              1.91            
REMARK 500   O    PHE C   414     OD1  ASP D   172              1.93            
REMARK 500   O    PHE A   414     OD1  ASP C   172              1.94            
REMARK 500   NH2  ARG D   830     CD   PRO D  1073              1.95            
REMARK 500   NH2  ARG C   830     CD   PRO C  1073              1.95            
REMARK 500   NH2  ARG A   830     CD   PRO A  1073              1.95            
REMARK 500   NH2  ARG B   830     CD   PRO B  1073              1.95            
REMARK 500   OD2  ASP B   172     CE2  PHE D   414              1.95            
REMARK 500   NH1  ARG A   139     CE2  PHE B   414              1.98            
REMARK 500   CE2  PHE A   414     OD2  ASP C   172              1.99            
REMARK 500   CE2  PHE C   414     NH1  ARG D   139              2.00            
REMARK 500   CD1  LEU D   463     CD2  TRP D   565              2.03            
REMARK 500   CD1  LEU A   463     CD2  TRP A   565              2.03            
REMARK 500   CD1  LEU B   463     CD2  TRP B   565              2.03            
REMARK 500   CD1  LEU C   463     CD2  TRP C   565              2.03            
REMARK 500   CE2  PHE C   414     OD2  ASP D   172              2.05            
REMARK 500   CE2  PHE A   414     NH1  ARG C   139              2.05            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      86 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A1023   CA  -  CB  -  CG  ANGL. DEV. =  20.1 DEGREES          
REMARK 500    LEU A1038   CA  -  CB  -  CG  ANGL. DEV. =  16.4 DEGREES          
REMARK 500    LEU A1056   CA  -  CB  -  CG  ANGL. DEV. =  14.8 DEGREES          
REMARK 500    PRO A1077   C   -  N   -  CA  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    LEU B1023   CA  -  CB  -  CG  ANGL. DEV. =  20.1 DEGREES          
REMARK 500    LEU B1038   CA  -  CB  -  CG  ANGL. DEV. =  16.4 DEGREES          
REMARK 500    LEU B1056   CA  -  CB  -  CG  ANGL. DEV. =  14.8 DEGREES          
REMARK 500    PRO B1077   C   -  N   -  CA  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    LEU C1023   CA  -  CB  -  CG  ANGL. DEV. =  20.1 DEGREES          
REMARK 500    LEU C1038   CA  -  CB  -  CG  ANGL. DEV. =  16.4 DEGREES          
REMARK 500    LEU C1056   CA  -  CB  -  CG  ANGL. DEV. =  14.8 DEGREES          
REMARK 500    PRO C1077   C   -  N   -  CA  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    LEU D1023   CA  -  CB  -  CG  ANGL. DEV. =  20.2 DEGREES          
REMARK 500    LEU D1038   CA  -  CB  -  CG  ANGL. DEV. =  16.4 DEGREES          
REMARK 500    LEU D1056   CA  -  CB  -  CG  ANGL. DEV. =  14.9 DEGREES          
REMARK 500    PRO D1077   C   -  N   -  CA  ANGL. DEV. =  14.0 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    THR A  97      -72.48    -63.65                                   
REMARK 500    ALA A 151       69.03     62.33                                   
REMARK 500    LYS A 182       72.16     59.27                                   
REMARK 500    THR A 199       73.88     56.56                                   
REMARK 500    LYS A 204       -8.88     70.03                                   
REMARK 500    GLN A 222       54.13   -117.82                                   
REMARK 500    THR A 318     -165.42    -78.46                                   
REMARK 500    LYS A 358      -12.05     69.93                                   
REMARK 500    LEU A 360       45.26    -89.44                                   
REMARK 500    SER A 370      -10.23     72.01                                   
REMARK 500    ALA A 392       70.51     57.89                                   
REMARK 500    ASP A 395       -8.73     73.31                                   
REMARK 500    GLU A 396      -17.67     70.31                                   
REMARK 500    ARG A 437       67.99     33.72                                   
REMARK 500    LEU A 455       34.01    -92.27                                   
REMARK 500    ILE A 473      -50.87   -125.57                                   
REMARK 500    TRP A 681       42.23    -94.34                                   
REMARK 500    MET A 684       18.15   -145.75                                   
REMARK 500    ALA A 685       78.08     59.30                                   
REMARK 500    SER A 686       -8.17    -52.07                                   
REMARK 500    TYR A 704       49.31    -93.77                                   
REMARK 500    LEU A 707     -161.32    -78.96                                   
REMARK 500    ILE A 708      123.36    -32.05                                   
REMARK 500    ALA A 850       -3.48     67.46                                   
REMARK 500    LEU A 860       46.99    -82.07                                   
REMARK 500    LEU A 887       31.35    -94.25                                   
REMARK 500    SER A 957       59.02    -99.54                                   
REMARK 500    HIS A 990       71.13     58.44                                   
REMARK 500    ILE A1033      -52.47   -127.31                                   
REMARK 500    PRO A1077      -51.91    -22.47                                   
REMARK 500    GLU A1167       20.20    -77.29                                   
REMARK 500    THR B  97      -72.50    -63.65                                   
REMARK 500    ALA B 151       69.02     62.33                                   
REMARK 500    LYS B 182       72.13     59.28                                   
REMARK 500    THR B 199       73.90     56.57                                   
REMARK 500    LYS B 204       -8.87     70.01                                   
REMARK 500    GLN B 222       54.12   -117.85                                   
REMARK 500    THR B 318     -165.42    -78.49                                   
REMARK 500    LYS B 358      -12.06     69.92                                   
REMARK 500    LEU B 360       45.20    -89.45                                   
REMARK 500    SER B 370      -10.26     72.08                                   
REMARK 500    ALA B 392       70.51     57.90                                   
REMARK 500    ASP B 395       -8.75     73.27                                   
REMARK 500    GLU B 396      -17.68     70.35                                   
REMARK 500    ARG B 437       67.99     33.73                                   
REMARK 500    LEU B 455       33.98    -92.27                                   
REMARK 500    ILE B 473      -50.84   -125.53                                   
REMARK 500    TRP B 681       42.27    -94.33                                   
REMARK 500    MET B 684       18.08   -145.73                                   
REMARK 500    ALA B 685       78.04     59.37                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     124 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ALA A  392     TYR A  393                 -145.41                    
REMARK 500 LEU A  707     ILE A  708                 -131.41                    
REMARK 500 ALA B  392     TYR B  393                 -145.46                    
REMARK 500 LEU B  707     ILE B  708                 -131.40                    
REMARK 500 ALA C  392     TYR C  393                 -145.43                    
REMARK 500 LEU C  707     ILE C  708                 -131.43                    
REMARK 500 ALA D  392     TYR D  393                 -145.42                    
REMARK 500 LEU D  707     ILE D  708                 -131.35                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-7133   RELATED DB: EMDB                              
REMARK 900 HUMAN TRPM4 ION CHANNEL IN LIPID NANODISCS IN A CALCIUM-BOUND STATE  
REMARK 900 RELATED ID: EMD-7132   RELATED DB: EMDB                              
REMARK 900 HUMAN TRPM4 ION CHANNEL IN LIPID NANODISCS IN A CALCIUM-FREE STATE   
DBREF  6BQV A    2  1214  UNP    Q8TD43   TRPM4_HUMAN      2   1214             
DBREF  6BQV B    2  1214  UNP    Q8TD43   TRPM4_HUMAN      2   1214             
DBREF  6BQV C    2  1214  UNP    Q8TD43   TRPM4_HUMAN      2   1214             
DBREF  6BQV D    2  1214  UNP    Q8TD43   TRPM4_HUMAN      2   1214             
SEQADV 6BQV SER A   -3  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV GLY A   -2  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV ARG A   -1  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV SER A    0  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV GLY A    1  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV SER B   -3  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV GLY B   -2  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV ARG B   -1  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV SER B    0  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV GLY B    1  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV SER C   -3  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV GLY C   -2  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV ARG C   -1  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV SER C    0  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV GLY C    1  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV SER D   -3  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV GLY D   -2  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV ARG D   -1  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV SER D    0  UNP  Q8TD43              EXPRESSION TAG                 
SEQADV 6BQV GLY D    1  UNP  Q8TD43              EXPRESSION TAG                 
SEQRES   1 A 1218  SER GLY ARG SER GLY VAL VAL PRO GLU LYS GLU GLN SER          
SEQRES   2 A 1218  TRP ILE PRO LYS ILE PHE LYS LYS LYS THR CYS THR THR          
SEQRES   3 A 1218  PHE ILE VAL ASP SER THR ASP PRO GLY GLY THR LEU CYS          
SEQRES   4 A 1218  GLN CYS GLY ARG PRO ARG THR ALA HIS PRO ALA VAL ALA          
SEQRES   5 A 1218  MET GLU ASP ALA PHE GLY ALA ALA VAL VAL THR VAL TRP          
SEQRES   6 A 1218  ASP SER ASP ALA HIS THR THR GLU LYS PRO THR ASP ALA          
SEQRES   7 A 1218  TYR GLY GLU LEU ASP PHE THR GLY ALA GLY ARG LYS HIS          
SEQRES   8 A 1218  SER ASN PHE LEU ARG LEU SER ASP ARG THR ASP PRO ALA          
SEQRES   9 A 1218  ALA VAL TYR SER LEU VAL THR ARG THR TRP GLY PHE ARG          
SEQRES  10 A 1218  ALA PRO ASN LEU VAL VAL SER VAL LEU GLY GLY SER GLY          
SEQRES  11 A 1218  GLY PRO VAL LEU GLN THR TRP LEU GLN ASP LEU LEU ARG          
SEQRES  12 A 1218  ARG GLY LEU VAL ARG ALA ALA GLN SER THR GLY ALA TRP          
SEQRES  13 A 1218  ILE VAL THR GLY GLY LEU HIS THR GLY ILE GLY ARG HIS          
SEQRES  14 A 1218  VAL GLY VAL ALA VAL ARG ASP HIS GLN MET ALA SER THR          
SEQRES  15 A 1218  GLY GLY THR LYS VAL VAL ALA MET GLY VAL ALA PRO TRP          
SEQRES  16 A 1218  GLY VAL VAL ARG ASN ARG ASP THR LEU ILE ASN PRO LYS          
SEQRES  17 A 1218  GLY SER PHE PRO ALA ARG TYR ARG TRP ARG GLY ASP PRO          
SEQRES  18 A 1218  GLU ASP GLY VAL GLN PHE PRO LEU ASP TYR ASN TYR SER          
SEQRES  19 A 1218  ALA PHE PHE LEU VAL ASP ASP GLY THR HIS GLY CYS LEU          
SEQRES  20 A 1218  GLY GLY GLU ASN ARG PHE ARG LEU ARG LEU GLU SER TYR          
SEQRES  21 A 1218  ILE SER GLN GLN LYS THR GLY VAL GLY GLY THR GLY ILE          
SEQRES  22 A 1218  ASP ILE PRO VAL LEU LEU LEU LEU ILE ASP GLY ASP GLU          
SEQRES  23 A 1218  LYS MET LEU THR ARG ILE GLU ASN ALA THR GLN ALA GLN          
SEQRES  24 A 1218  LEU PRO CYS LEU LEU VAL ALA GLY SER GLY GLY ALA ALA          
SEQRES  25 A 1218  ASP CYS LEU ALA GLU THR LEU GLU ASP THR LEU ALA PRO          
SEQRES  26 A 1218  GLY SER GLY GLY ALA ARG GLN GLY GLU ALA ARG ASP ARG          
SEQRES  27 A 1218  ILE ARG ARG PHE PHE PRO LYS GLY ASP LEU GLU VAL LEU          
SEQRES  28 A 1218  GLN ALA GLN VAL GLU ARG ILE MET THR ARG LYS GLU LEU          
SEQRES  29 A 1218  LEU THR VAL TYR SER SER GLU ASP GLY SER GLU GLU PHE          
SEQRES  30 A 1218  GLU THR ILE VAL LEU LYS ALA LEU VAL LYS ALA CYS GLY          
SEQRES  31 A 1218  SER SER GLU ALA SER ALA TYR LEU ASP GLU LEU ARG LEU          
SEQRES  32 A 1218  ALA VAL ALA TRP ASN ARG VAL ASP ILE ALA GLN SER GLU          
SEQRES  33 A 1218  LEU PHE ARG GLY ASP ILE GLN TRP ARG SER PHE HIS LEU          
SEQRES  34 A 1218  GLU ALA SER LEU MET ASP ALA LEU LEU ASN ASP ARG PRO          
SEQRES  35 A 1218  GLU PHE VAL ARG LEU LEU ILE SER HIS GLY LEU SER LEU          
SEQRES  36 A 1218  GLY HIS PHE LEU THR PRO MET ARG LEU ALA GLN LEU TYR          
SEQRES  37 A 1218  SER ALA ALA PRO SER ASN SER LEU ILE ARG ASN LEU LEU          
SEQRES  38 A 1218  ASP GLN ALA SER HIS SER ALA GLY THR LYS ALA PRO ALA          
SEQRES  39 A 1218  LEU LYS GLY GLY ALA ALA GLU LEU ARG PRO PRO ASP VAL          
SEQRES  40 A 1218  GLY HIS VAL LEU ARG MET LEU LEU GLY LYS MET CYS ALA          
SEQRES  41 A 1218  PRO ARG TYR PRO SER GLY GLY ALA TRP ASP PRO HIS PRO          
SEQRES  42 A 1218  GLY GLN GLY PHE GLY GLU SER MET TYR LEU LEU SER ASP          
SEQRES  43 A 1218  LYS ALA THR SER PRO LEU SER LEU ASP ALA GLY LEU GLY          
SEQRES  44 A 1218  GLN ALA PRO TRP SER ASP LEU LEU LEU TRP ALA LEU LEU          
SEQRES  45 A 1218  LEU ASN ARG ALA GLN MET ALA MET TYR PHE TRP GLU MET          
SEQRES  46 A 1218  GLY SER ASN ALA VAL SER SER ALA LEU GLY ALA CYS LEU          
SEQRES  47 A 1218  LEU LEU ARG VAL MET ALA ARG LEU GLU PRO ASP ALA GLU          
SEQRES  48 A 1218  GLU ALA ALA ARG ARG LYS ASP LEU ALA PHE LYS PHE GLU          
SEQRES  49 A 1218  GLY MET GLY VAL ASP LEU PHE GLY GLU CYS TYR ARG SER          
SEQRES  50 A 1218  SER GLU VAL ARG ALA ALA ARG LEU LEU LEU ARG ARG CYS          
SEQRES  51 A 1218  PRO LEU TRP GLY ASP ALA THR CYS LEU GLN LEU ALA MET          
SEQRES  52 A 1218  GLN ALA ASP ALA ARG ALA PHE PHE ALA GLN ASP GLY VAL          
SEQRES  53 A 1218  GLN SER LEU LEU THR GLN LYS TRP TRP GLY ASP MET ALA          
SEQRES  54 A 1218  SER THR THR PRO ILE TRP ALA LEU VAL LEU ALA PHE PHE          
SEQRES  55 A 1218  CYS PRO PRO LEU ILE TYR THR ARG LEU ILE THR PHE ARG          
SEQRES  56 A 1218  LYS SER GLU GLU GLU PRO THR ARG GLU GLU LEU GLU PHE          
SEQRES  57 A 1218  ASP MET ASP SER VAL ILE ASN GLY GLU GLY PRO VAL GLY          
SEQRES  58 A 1218  THR ALA ASP PRO ALA GLU LYS THR PRO LEU GLY VAL PRO          
SEQRES  59 A 1218  ARG GLN SER GLY ARG PRO GLY CYS CYS GLY GLY ARG CYS          
SEQRES  60 A 1218  GLY GLY ARG ARG CYS LEU ARG ARG TRP PHE HIS PHE TRP          
SEQRES  61 A 1218  GLY ALA PRO VAL THR ILE PHE MET GLY ASN VAL VAL SER          
SEQRES  62 A 1218  TYR LEU LEU PHE LEU LEU LEU PHE SER ARG VAL LEU LEU          
SEQRES  63 A 1218  VAL ASP PHE GLN PRO ALA PRO PRO GLY SER LEU GLU LEU          
SEQRES  64 A 1218  LEU LEU TYR PHE TRP ALA PHE THR LEU LEU CYS GLU GLU          
SEQRES  65 A 1218  LEU ARG GLN GLY LEU SER GLY GLY GLY GLY SER LEU ALA          
SEQRES  66 A 1218  SER GLY GLY PRO GLY PRO GLY HIS ALA SER LEU SER GLN          
SEQRES  67 A 1218  ARG LEU ARG LEU TYR LEU ALA ASP SER TRP ASN GLN CYS          
SEQRES  68 A 1218  ASP LEU VAL ALA LEU THR CYS PHE LEU LEU GLY VAL GLY          
SEQRES  69 A 1218  CYS ARG LEU THR PRO GLY LEU TYR HIS LEU GLY ARG THR          
SEQRES  70 A 1218  VAL LEU CYS ILE ASP PHE MET VAL PHE THR VAL ARG LEU          
SEQRES  71 A 1218  LEU HIS ILE PHE THR VAL ASN LYS GLN LEU GLY PRO LYS          
SEQRES  72 A 1218  ILE VAL ILE VAL SER LYS MET MET LYS ASP VAL PHE PHE          
SEQRES  73 A 1218  PHE LEU PHE PHE LEU GLY VAL TRP LEU VAL ALA TYR GLY          
SEQRES  74 A 1218  VAL ALA THR GLU GLY LEU LEU ARG PRO ARG ASP SER ASP          
SEQRES  75 A 1218  PHE PRO SER ILE LEU ARG ARG VAL PHE TYR ARG PRO TYR          
SEQRES  76 A 1218  LEU GLN ILE PHE GLY GLN ILE PRO GLN GLU ASP MET ASP          
SEQRES  77 A 1218  VAL ALA LEU MET GLU HIS SER ASN CYS SER SER GLU PRO          
SEQRES  78 A 1218  GLY PHE TRP ALA HIS PRO PRO GLY ALA GLN ALA GLY THR          
SEQRES  79 A 1218  CYS VAL SER GLN TYR ALA ASN TRP LEU VAL VAL LEU LEU          
SEQRES  80 A 1218  LEU VAL ILE PHE LEU LEU VAL ALA ASN ILE LEU LEU VAL          
SEQRES  81 A 1218  ASN LEU LEU ILE ALA MET PHE SER TYR THR PHE GLY LYS          
SEQRES  82 A 1218  VAL GLN GLY ASN SER ASP LEU TYR TRP LYS ALA GLN ARG          
SEQRES  83 A 1218  TYR ARG LEU ILE ARG GLU PHE HIS SER ARG PRO ALA LEU          
SEQRES  84 A 1218  ALA PRO PRO PHE ILE VAL ILE SER HIS LEU ARG LEU LEU          
SEQRES  85 A 1218  LEU ARG GLN LEU CYS ARG ARG PRO ARG SER PRO GLN PRO          
SEQRES  86 A 1218  SER SER PRO ALA LEU GLU HIS PHE ARG VAL TYR LEU SER          
SEQRES  87 A 1218  LYS GLU ALA GLU ARG LYS LEU LEU THR TRP GLU SER VAL          
SEQRES  88 A 1218  HIS LYS GLU ASN PHE LEU LEU ALA ARG ALA ARG ASP LYS          
SEQRES  89 A 1218  ARG GLU SER ASP SER GLU ARG LEU LYS ARG THR SER GLN          
SEQRES  90 A 1218  LYS VAL ASP LEU ALA LEU LYS GLN LEU GLY HIS ILE ARG          
SEQRES  91 A 1218  GLU TYR GLU GLN ARG LEU LYS VAL LEU GLU ARG GLU VAL          
SEQRES  92 A 1218  GLN GLN CYS SER ARG VAL LEU GLY TRP VAL ALA GLU ALA          
SEQRES  93 A 1218  LEU SER ARG SER ALA LEU LEU PRO PRO GLY GLY PRO PRO          
SEQRES  94 A 1218  PRO PRO ASP LEU PRO GLY SER LYS ASP                          
SEQRES   1 B 1218  SER GLY ARG SER GLY VAL VAL PRO GLU LYS GLU GLN SER          
SEQRES   2 B 1218  TRP ILE PRO LYS ILE PHE LYS LYS LYS THR CYS THR THR          
SEQRES   3 B 1218  PHE ILE VAL ASP SER THR ASP PRO GLY GLY THR LEU CYS          
SEQRES   4 B 1218  GLN CYS GLY ARG PRO ARG THR ALA HIS PRO ALA VAL ALA          
SEQRES   5 B 1218  MET GLU ASP ALA PHE GLY ALA ALA VAL VAL THR VAL TRP          
SEQRES   6 B 1218  ASP SER ASP ALA HIS THR THR GLU LYS PRO THR ASP ALA          
SEQRES   7 B 1218  TYR GLY GLU LEU ASP PHE THR GLY ALA GLY ARG LYS HIS          
SEQRES   8 B 1218  SER ASN PHE LEU ARG LEU SER ASP ARG THR ASP PRO ALA          
SEQRES   9 B 1218  ALA VAL TYR SER LEU VAL THR ARG THR TRP GLY PHE ARG          
SEQRES  10 B 1218  ALA PRO ASN LEU VAL VAL SER VAL LEU GLY GLY SER GLY          
SEQRES  11 B 1218  GLY PRO VAL LEU GLN THR TRP LEU GLN ASP LEU LEU ARG          
SEQRES  12 B 1218  ARG GLY LEU VAL ARG ALA ALA GLN SER THR GLY ALA TRP          
SEQRES  13 B 1218  ILE VAL THR GLY GLY LEU HIS THR GLY ILE GLY ARG HIS          
SEQRES  14 B 1218  VAL GLY VAL ALA VAL ARG ASP HIS GLN MET ALA SER THR          
SEQRES  15 B 1218  GLY GLY THR LYS VAL VAL ALA MET GLY VAL ALA PRO TRP          
SEQRES  16 B 1218  GLY VAL VAL ARG ASN ARG ASP THR LEU ILE ASN PRO LYS          
SEQRES  17 B 1218  GLY SER PHE PRO ALA ARG TYR ARG TRP ARG GLY ASP PRO          
SEQRES  18 B 1218  GLU ASP GLY VAL GLN PHE PRO LEU ASP TYR ASN TYR SER          
SEQRES  19 B 1218  ALA PHE PHE LEU VAL ASP ASP GLY THR HIS GLY CYS LEU          
SEQRES  20 B 1218  GLY GLY GLU ASN ARG PHE ARG LEU ARG LEU GLU SER TYR          
SEQRES  21 B 1218  ILE SER GLN GLN LYS THR GLY VAL GLY GLY THR GLY ILE          
SEQRES  22 B 1218  ASP ILE PRO VAL LEU LEU LEU LEU ILE ASP GLY ASP GLU          
SEQRES  23 B 1218  LYS MET LEU THR ARG ILE GLU ASN ALA THR GLN ALA GLN          
SEQRES  24 B 1218  LEU PRO CYS LEU LEU VAL ALA GLY SER GLY GLY ALA ALA          
SEQRES  25 B 1218  ASP CYS LEU ALA GLU THR LEU GLU ASP THR LEU ALA PRO          
SEQRES  26 B 1218  GLY SER GLY GLY ALA ARG GLN GLY GLU ALA ARG ASP ARG          
SEQRES  27 B 1218  ILE ARG ARG PHE PHE PRO LYS GLY ASP LEU GLU VAL LEU          
SEQRES  28 B 1218  GLN ALA GLN VAL GLU ARG ILE MET THR ARG LYS GLU LEU          
SEQRES  29 B 1218  LEU THR VAL TYR SER SER GLU ASP GLY SER GLU GLU PHE          
SEQRES  30 B 1218  GLU THR ILE VAL LEU LYS ALA LEU VAL LYS ALA CYS GLY          
SEQRES  31 B 1218  SER SER GLU ALA SER ALA TYR LEU ASP GLU LEU ARG LEU          
SEQRES  32 B 1218  ALA VAL ALA TRP ASN ARG VAL ASP ILE ALA GLN SER GLU          
SEQRES  33 B 1218  LEU PHE ARG GLY ASP ILE GLN TRP ARG SER PHE HIS LEU          
SEQRES  34 B 1218  GLU ALA SER LEU MET ASP ALA LEU LEU ASN ASP ARG PRO          
SEQRES  35 B 1218  GLU PHE VAL ARG LEU LEU ILE SER HIS GLY LEU SER LEU          
SEQRES  36 B 1218  GLY HIS PHE LEU THR PRO MET ARG LEU ALA GLN LEU TYR          
SEQRES  37 B 1218  SER ALA ALA PRO SER ASN SER LEU ILE ARG ASN LEU LEU          
SEQRES  38 B 1218  ASP GLN ALA SER HIS SER ALA GLY THR LYS ALA PRO ALA          
SEQRES  39 B 1218  LEU LYS GLY GLY ALA ALA GLU LEU ARG PRO PRO ASP VAL          
SEQRES  40 B 1218  GLY HIS VAL LEU ARG MET LEU LEU GLY LYS MET CYS ALA          
SEQRES  41 B 1218  PRO ARG TYR PRO SER GLY GLY ALA TRP ASP PRO HIS PRO          
SEQRES  42 B 1218  GLY GLN GLY PHE GLY GLU SER MET TYR LEU LEU SER ASP          
SEQRES  43 B 1218  LYS ALA THR SER PRO LEU SER LEU ASP ALA GLY LEU GLY          
SEQRES  44 B 1218  GLN ALA PRO TRP SER ASP LEU LEU LEU TRP ALA LEU LEU          
SEQRES  45 B 1218  LEU ASN ARG ALA GLN MET ALA MET TYR PHE TRP GLU MET          
SEQRES  46 B 1218  GLY SER ASN ALA VAL SER SER ALA LEU GLY ALA CYS LEU          
SEQRES  47 B 1218  LEU LEU ARG VAL MET ALA ARG LEU GLU PRO ASP ALA GLU          
SEQRES  48 B 1218  GLU ALA ALA ARG ARG LYS ASP LEU ALA PHE LYS PHE GLU          
SEQRES  49 B 1218  GLY MET GLY VAL ASP LEU PHE GLY GLU CYS TYR ARG SER          
SEQRES  50 B 1218  SER GLU VAL ARG ALA ALA ARG LEU LEU LEU ARG ARG CYS          
SEQRES  51 B 1218  PRO LEU TRP GLY ASP ALA THR CYS LEU GLN LEU ALA MET          
SEQRES  52 B 1218  GLN ALA ASP ALA ARG ALA PHE PHE ALA GLN ASP GLY VAL          
SEQRES  53 B 1218  GLN SER LEU LEU THR GLN LYS TRP TRP GLY ASP MET ALA          
SEQRES  54 B 1218  SER THR THR PRO ILE TRP ALA LEU VAL LEU ALA PHE PHE          
SEQRES  55 B 1218  CYS PRO PRO LEU ILE TYR THR ARG LEU ILE THR PHE ARG          
SEQRES  56 B 1218  LYS SER GLU GLU GLU PRO THR ARG GLU GLU LEU GLU PHE          
SEQRES  57 B 1218  ASP MET ASP SER VAL ILE ASN GLY GLU GLY PRO VAL GLY          
SEQRES  58 B 1218  THR ALA ASP PRO ALA GLU LYS THR PRO LEU GLY VAL PRO          
SEQRES  59 B 1218  ARG GLN SER GLY ARG PRO GLY CYS CYS GLY GLY ARG CYS          
SEQRES  60 B 1218  GLY GLY ARG ARG CYS LEU ARG ARG TRP PHE HIS PHE TRP          
SEQRES  61 B 1218  GLY ALA PRO VAL THR ILE PHE MET GLY ASN VAL VAL SER          
SEQRES  62 B 1218  TYR LEU LEU PHE LEU LEU LEU PHE SER ARG VAL LEU LEU          
SEQRES  63 B 1218  VAL ASP PHE GLN PRO ALA PRO PRO GLY SER LEU GLU LEU          
SEQRES  64 B 1218  LEU LEU TYR PHE TRP ALA PHE THR LEU LEU CYS GLU GLU          
SEQRES  65 B 1218  LEU ARG GLN GLY LEU SER GLY GLY GLY GLY SER LEU ALA          
SEQRES  66 B 1218  SER GLY GLY PRO GLY PRO GLY HIS ALA SER LEU SER GLN          
SEQRES  67 B 1218  ARG LEU ARG LEU TYR LEU ALA ASP SER TRP ASN GLN CYS          
SEQRES  68 B 1218  ASP LEU VAL ALA LEU THR CYS PHE LEU LEU GLY VAL GLY          
SEQRES  69 B 1218  CYS ARG LEU THR PRO GLY LEU TYR HIS LEU GLY ARG THR          
SEQRES  70 B 1218  VAL LEU CYS ILE ASP PHE MET VAL PHE THR VAL ARG LEU          
SEQRES  71 B 1218  LEU HIS ILE PHE THR VAL ASN LYS GLN LEU GLY PRO LYS          
SEQRES  72 B 1218  ILE VAL ILE VAL SER LYS MET MET LYS ASP VAL PHE PHE          
SEQRES  73 B 1218  PHE LEU PHE PHE LEU GLY VAL TRP LEU VAL ALA TYR GLY          
SEQRES  74 B 1218  VAL ALA THR GLU GLY LEU LEU ARG PRO ARG ASP SER ASP          
SEQRES  75 B 1218  PHE PRO SER ILE LEU ARG ARG VAL PHE TYR ARG PRO TYR          
SEQRES  76 B 1218  LEU GLN ILE PHE GLY GLN ILE PRO GLN GLU ASP MET ASP          
SEQRES  77 B 1218  VAL ALA LEU MET GLU HIS SER ASN CYS SER SER GLU PRO          
SEQRES  78 B 1218  GLY PHE TRP ALA HIS PRO PRO GLY ALA GLN ALA GLY THR          
SEQRES  79 B 1218  CYS VAL SER GLN TYR ALA ASN TRP LEU VAL VAL LEU LEU          
SEQRES  80 B 1218  LEU VAL ILE PHE LEU LEU VAL ALA ASN ILE LEU LEU VAL          
SEQRES  81 B 1218  ASN LEU LEU ILE ALA MET PHE SER TYR THR PHE GLY LYS          
SEQRES  82 B 1218  VAL GLN GLY ASN SER ASP LEU TYR TRP LYS ALA GLN ARG          
SEQRES  83 B 1218  TYR ARG LEU ILE ARG GLU PHE HIS SER ARG PRO ALA LEU          
SEQRES  84 B 1218  ALA PRO PRO PHE ILE VAL ILE SER HIS LEU ARG LEU LEU          
SEQRES  85 B 1218  LEU ARG GLN LEU CYS ARG ARG PRO ARG SER PRO GLN PRO          
SEQRES  86 B 1218  SER SER PRO ALA LEU GLU HIS PHE ARG VAL TYR LEU SER          
SEQRES  87 B 1218  LYS GLU ALA GLU ARG LYS LEU LEU THR TRP GLU SER VAL          
SEQRES  88 B 1218  HIS LYS GLU ASN PHE LEU LEU ALA ARG ALA ARG ASP LYS          
SEQRES  89 B 1218  ARG GLU SER ASP SER GLU ARG LEU LYS ARG THR SER GLN          
SEQRES  90 B 1218  LYS VAL ASP LEU ALA LEU LYS GLN LEU GLY HIS ILE ARG          
SEQRES  91 B 1218  GLU TYR GLU GLN ARG LEU LYS VAL LEU GLU ARG GLU VAL          
SEQRES  92 B 1218  GLN GLN CYS SER ARG VAL LEU GLY TRP VAL ALA GLU ALA          
SEQRES  93 B 1218  LEU SER ARG SER ALA LEU LEU PRO PRO GLY GLY PRO PRO          
SEQRES  94 B 1218  PRO PRO ASP LEU PRO GLY SER LYS ASP                          
SEQRES   1 C 1218  SER GLY ARG SER GLY VAL VAL PRO GLU LYS GLU GLN SER          
SEQRES   2 C 1218  TRP ILE PRO LYS ILE PHE LYS LYS LYS THR CYS THR THR          
SEQRES   3 C 1218  PHE ILE VAL ASP SER THR ASP PRO GLY GLY THR LEU CYS          
SEQRES   4 C 1218  GLN CYS GLY ARG PRO ARG THR ALA HIS PRO ALA VAL ALA          
SEQRES   5 C 1218  MET GLU ASP ALA PHE GLY ALA ALA VAL VAL THR VAL TRP          
SEQRES   6 C 1218  ASP SER ASP ALA HIS THR THR GLU LYS PRO THR ASP ALA          
SEQRES   7 C 1218  TYR GLY GLU LEU ASP PHE THR GLY ALA GLY ARG LYS HIS          
SEQRES   8 C 1218  SER ASN PHE LEU ARG LEU SER ASP ARG THR ASP PRO ALA          
SEQRES   9 C 1218  ALA VAL TYR SER LEU VAL THR ARG THR TRP GLY PHE ARG          
SEQRES  10 C 1218  ALA PRO ASN LEU VAL VAL SER VAL LEU GLY GLY SER GLY          
SEQRES  11 C 1218  GLY PRO VAL LEU GLN THR TRP LEU GLN ASP LEU LEU ARG          
SEQRES  12 C 1218  ARG GLY LEU VAL ARG ALA ALA GLN SER THR GLY ALA TRP          
SEQRES  13 C 1218  ILE VAL THR GLY GLY LEU HIS THR GLY ILE GLY ARG HIS          
SEQRES  14 C 1218  VAL GLY VAL ALA VAL ARG ASP HIS GLN MET ALA SER THR          
SEQRES  15 C 1218  GLY GLY THR LYS VAL VAL ALA MET GLY VAL ALA PRO TRP          
SEQRES  16 C 1218  GLY VAL VAL ARG ASN ARG ASP THR LEU ILE ASN PRO LYS          
SEQRES  17 C 1218  GLY SER PHE PRO ALA ARG TYR ARG TRP ARG GLY ASP PRO          
SEQRES  18 C 1218  GLU ASP GLY VAL GLN PHE PRO LEU ASP TYR ASN TYR SER          
SEQRES  19 C 1218  ALA PHE PHE LEU VAL ASP ASP GLY THR HIS GLY CYS LEU          
SEQRES  20 C 1218  GLY GLY GLU ASN ARG PHE ARG LEU ARG LEU GLU SER TYR          
SEQRES  21 C 1218  ILE SER GLN GLN LYS THR GLY VAL GLY GLY THR GLY ILE          
SEQRES  22 C 1218  ASP ILE PRO VAL LEU LEU LEU LEU ILE ASP GLY ASP GLU          
SEQRES  23 C 1218  LYS MET LEU THR ARG ILE GLU ASN ALA THR GLN ALA GLN          
SEQRES  24 C 1218  LEU PRO CYS LEU LEU VAL ALA GLY SER GLY GLY ALA ALA          
SEQRES  25 C 1218  ASP CYS LEU ALA GLU THR LEU GLU ASP THR LEU ALA PRO          
SEQRES  26 C 1218  GLY SER GLY GLY ALA ARG GLN GLY GLU ALA ARG ASP ARG          
SEQRES  27 C 1218  ILE ARG ARG PHE PHE PRO LYS GLY ASP LEU GLU VAL LEU          
SEQRES  28 C 1218  GLN ALA GLN VAL GLU ARG ILE MET THR ARG LYS GLU LEU          
SEQRES  29 C 1218  LEU THR VAL TYR SER SER GLU ASP GLY SER GLU GLU PHE          
SEQRES  30 C 1218  GLU THR ILE VAL LEU LYS ALA LEU VAL LYS ALA CYS GLY          
SEQRES  31 C 1218  SER SER GLU ALA SER ALA TYR LEU ASP GLU LEU ARG LEU          
SEQRES  32 C 1218  ALA VAL ALA TRP ASN ARG VAL ASP ILE ALA GLN SER GLU          
SEQRES  33 C 1218  LEU PHE ARG GLY ASP ILE GLN TRP ARG SER PHE HIS LEU          
SEQRES  34 C 1218  GLU ALA SER LEU MET ASP ALA LEU LEU ASN ASP ARG PRO          
SEQRES  35 C 1218  GLU PHE VAL ARG LEU LEU ILE SER HIS GLY LEU SER LEU          
SEQRES  36 C 1218  GLY HIS PHE LEU THR PRO MET ARG LEU ALA GLN LEU TYR          
SEQRES  37 C 1218  SER ALA ALA PRO SER ASN SER LEU ILE ARG ASN LEU LEU          
SEQRES  38 C 1218  ASP GLN ALA SER HIS SER ALA GLY THR LYS ALA PRO ALA          
SEQRES  39 C 1218  LEU LYS GLY GLY ALA ALA GLU LEU ARG PRO PRO ASP VAL          
SEQRES  40 C 1218  GLY HIS VAL LEU ARG MET LEU LEU GLY LYS MET CYS ALA          
SEQRES  41 C 1218  PRO ARG TYR PRO SER GLY GLY ALA TRP ASP PRO HIS PRO          
SEQRES  42 C 1218  GLY GLN GLY PHE GLY GLU SER MET TYR LEU LEU SER ASP          
SEQRES  43 C 1218  LYS ALA THR SER PRO LEU SER LEU ASP ALA GLY LEU GLY          
SEQRES  44 C 1218  GLN ALA PRO TRP SER ASP LEU LEU LEU TRP ALA LEU LEU          
SEQRES  45 C 1218  LEU ASN ARG ALA GLN MET ALA MET TYR PHE TRP GLU MET          
SEQRES  46 C 1218  GLY SER ASN ALA VAL SER SER ALA LEU GLY ALA CYS LEU          
SEQRES  47 C 1218  LEU LEU ARG VAL MET ALA ARG LEU GLU PRO ASP ALA GLU          
SEQRES  48 C 1218  GLU ALA ALA ARG ARG LYS ASP LEU ALA PHE LYS PHE GLU          
SEQRES  49 C 1218  GLY MET GLY VAL ASP LEU PHE GLY GLU CYS TYR ARG SER          
SEQRES  50 C 1218  SER GLU VAL ARG ALA ALA ARG LEU LEU LEU ARG ARG CYS          
SEQRES  51 C 1218  PRO LEU TRP GLY ASP ALA THR CYS LEU GLN LEU ALA MET          
SEQRES  52 C 1218  GLN ALA ASP ALA ARG ALA PHE PHE ALA GLN ASP GLY VAL          
SEQRES  53 C 1218  GLN SER LEU LEU THR GLN LYS TRP TRP GLY ASP MET ALA          
SEQRES  54 C 1218  SER THR THR PRO ILE TRP ALA LEU VAL LEU ALA PHE PHE          
SEQRES  55 C 1218  CYS PRO PRO LEU ILE TYR THR ARG LEU ILE THR PHE ARG          
SEQRES  56 C 1218  LYS SER GLU GLU GLU PRO THR ARG GLU GLU LEU GLU PHE          
SEQRES  57 C 1218  ASP MET ASP SER VAL ILE ASN GLY GLU GLY PRO VAL GLY          
SEQRES  58 C 1218  THR ALA ASP PRO ALA GLU LYS THR PRO LEU GLY VAL PRO          
SEQRES  59 C 1218  ARG GLN SER GLY ARG PRO GLY CYS CYS GLY GLY ARG CYS          
SEQRES  60 C 1218  GLY GLY ARG ARG CYS LEU ARG ARG TRP PHE HIS PHE TRP          
SEQRES  61 C 1218  GLY ALA PRO VAL THR ILE PHE MET GLY ASN VAL VAL SER          
SEQRES  62 C 1218  TYR LEU LEU PHE LEU LEU LEU PHE SER ARG VAL LEU LEU          
SEQRES  63 C 1218  VAL ASP PHE GLN PRO ALA PRO PRO GLY SER LEU GLU LEU          
SEQRES  64 C 1218  LEU LEU TYR PHE TRP ALA PHE THR LEU LEU CYS GLU GLU          
SEQRES  65 C 1218  LEU ARG GLN GLY LEU SER GLY GLY GLY GLY SER LEU ALA          
SEQRES  66 C 1218  SER GLY GLY PRO GLY PRO GLY HIS ALA SER LEU SER GLN          
SEQRES  67 C 1218  ARG LEU ARG LEU TYR LEU ALA ASP SER TRP ASN GLN CYS          
SEQRES  68 C 1218  ASP LEU VAL ALA LEU THR CYS PHE LEU LEU GLY VAL GLY          
SEQRES  69 C 1218  CYS ARG LEU THR PRO GLY LEU TYR HIS LEU GLY ARG THR          
SEQRES  70 C 1218  VAL LEU CYS ILE ASP PHE MET VAL PHE THR VAL ARG LEU          
SEQRES  71 C 1218  LEU HIS ILE PHE THR VAL ASN LYS GLN LEU GLY PRO LYS          
SEQRES  72 C 1218  ILE VAL ILE VAL SER LYS MET MET LYS ASP VAL PHE PHE          
SEQRES  73 C 1218  PHE LEU PHE PHE LEU GLY VAL TRP LEU VAL ALA TYR GLY          
SEQRES  74 C 1218  VAL ALA THR GLU GLY LEU LEU ARG PRO ARG ASP SER ASP          
SEQRES  75 C 1218  PHE PRO SER ILE LEU ARG ARG VAL PHE TYR ARG PRO TYR          
SEQRES  76 C 1218  LEU GLN ILE PHE GLY GLN ILE PRO GLN GLU ASP MET ASP          
SEQRES  77 C 1218  VAL ALA LEU MET GLU HIS SER ASN CYS SER SER GLU PRO          
SEQRES  78 C 1218  GLY PHE TRP ALA HIS PRO PRO GLY ALA GLN ALA GLY THR          
SEQRES  79 C 1218  CYS VAL SER GLN TYR ALA ASN TRP LEU VAL VAL LEU LEU          
SEQRES  80 C 1218  LEU VAL ILE PHE LEU LEU VAL ALA ASN ILE LEU LEU VAL          
SEQRES  81 C 1218  ASN LEU LEU ILE ALA MET PHE SER TYR THR PHE GLY LYS          
SEQRES  82 C 1218  VAL GLN GLY ASN SER ASP LEU TYR TRP LYS ALA GLN ARG          
SEQRES  83 C 1218  TYR ARG LEU ILE ARG GLU PHE HIS SER ARG PRO ALA LEU          
SEQRES  84 C 1218  ALA PRO PRO PHE ILE VAL ILE SER HIS LEU ARG LEU LEU          
SEQRES  85 C 1218  LEU ARG GLN LEU CYS ARG ARG PRO ARG SER PRO GLN PRO          
SEQRES  86 C 1218  SER SER PRO ALA LEU GLU HIS PHE ARG VAL TYR LEU SER          
SEQRES  87 C 1218  LYS GLU ALA GLU ARG LYS LEU LEU THR TRP GLU SER VAL          
SEQRES  88 C 1218  HIS LYS GLU ASN PHE LEU LEU ALA ARG ALA ARG ASP LYS          
SEQRES  89 C 1218  ARG GLU SER ASP SER GLU ARG LEU LYS ARG THR SER GLN          
SEQRES  90 C 1218  LYS VAL ASP LEU ALA LEU LYS GLN LEU GLY HIS ILE ARG          
SEQRES  91 C 1218  GLU TYR GLU GLN ARG LEU LYS VAL LEU GLU ARG GLU VAL          
SEQRES  92 C 1218  GLN GLN CYS SER ARG VAL LEU GLY TRP VAL ALA GLU ALA          
SEQRES  93 C 1218  LEU SER ARG SER ALA LEU LEU PRO PRO GLY GLY PRO PRO          
SEQRES  94 C 1218  PRO PRO ASP LEU PRO GLY SER LYS ASP                          
SEQRES   1 D 1218  SER GLY ARG SER GLY VAL VAL PRO GLU LYS GLU GLN SER          
SEQRES   2 D 1218  TRP ILE PRO LYS ILE PHE LYS LYS LYS THR CYS THR THR          
SEQRES   3 D 1218  PHE ILE VAL ASP SER THR ASP PRO GLY GLY THR LEU CYS          
SEQRES   4 D 1218  GLN CYS GLY ARG PRO ARG THR ALA HIS PRO ALA VAL ALA          
SEQRES   5 D 1218  MET GLU ASP ALA PHE GLY ALA ALA VAL VAL THR VAL TRP          
SEQRES   6 D 1218  ASP SER ASP ALA HIS THR THR GLU LYS PRO THR ASP ALA          
SEQRES   7 D 1218  TYR GLY GLU LEU ASP PHE THR GLY ALA GLY ARG LYS HIS          
SEQRES   8 D 1218  SER ASN PHE LEU ARG LEU SER ASP ARG THR ASP PRO ALA          
SEQRES   9 D 1218  ALA VAL TYR SER LEU VAL THR ARG THR TRP GLY PHE ARG          
SEQRES  10 D 1218  ALA PRO ASN LEU VAL VAL SER VAL LEU GLY GLY SER GLY          
SEQRES  11 D 1218  GLY PRO VAL LEU GLN THR TRP LEU GLN ASP LEU LEU ARG          
SEQRES  12 D 1218  ARG GLY LEU VAL ARG ALA ALA GLN SER THR GLY ALA TRP          
SEQRES  13 D 1218  ILE VAL THR GLY GLY LEU HIS THR GLY ILE GLY ARG HIS          
SEQRES  14 D 1218  VAL GLY VAL ALA VAL ARG ASP HIS GLN MET ALA SER THR          
SEQRES  15 D 1218  GLY GLY THR LYS VAL VAL ALA MET GLY VAL ALA PRO TRP          
SEQRES  16 D 1218  GLY VAL VAL ARG ASN ARG ASP THR LEU ILE ASN PRO LYS          
SEQRES  17 D 1218  GLY SER PHE PRO ALA ARG TYR ARG TRP ARG GLY ASP PRO          
SEQRES  18 D 1218  GLU ASP GLY VAL GLN PHE PRO LEU ASP TYR ASN TYR SER          
SEQRES  19 D 1218  ALA PHE PHE LEU VAL ASP ASP GLY THR HIS GLY CYS LEU          
SEQRES  20 D 1218  GLY GLY GLU ASN ARG PHE ARG LEU ARG LEU GLU SER TYR          
SEQRES  21 D 1218  ILE SER GLN GLN LYS THR GLY VAL GLY GLY THR GLY ILE          
SEQRES  22 D 1218  ASP ILE PRO VAL LEU LEU LEU LEU ILE ASP GLY ASP GLU          
SEQRES  23 D 1218  LYS MET LEU THR ARG ILE GLU ASN ALA THR GLN ALA GLN          
SEQRES  24 D 1218  LEU PRO CYS LEU LEU VAL ALA GLY SER GLY GLY ALA ALA          
SEQRES  25 D 1218  ASP CYS LEU ALA GLU THR LEU GLU ASP THR LEU ALA PRO          
SEQRES  26 D 1218  GLY SER GLY GLY ALA ARG GLN GLY GLU ALA ARG ASP ARG          
SEQRES  27 D 1218  ILE ARG ARG PHE PHE PRO LYS GLY ASP LEU GLU VAL LEU          
SEQRES  28 D 1218  GLN ALA GLN VAL GLU ARG ILE MET THR ARG LYS GLU LEU          
SEQRES  29 D 1218  LEU THR VAL TYR SER SER GLU ASP GLY SER GLU GLU PHE          
SEQRES  30 D 1218  GLU THR ILE VAL LEU LYS ALA LEU VAL LYS ALA CYS GLY          
SEQRES  31 D 1218  SER SER GLU ALA SER ALA TYR LEU ASP GLU LEU ARG LEU          
SEQRES  32 D 1218  ALA VAL ALA TRP ASN ARG VAL ASP ILE ALA GLN SER GLU          
SEQRES  33 D 1218  LEU PHE ARG GLY ASP ILE GLN TRP ARG SER PHE HIS LEU          
SEQRES  34 D 1218  GLU ALA SER LEU MET ASP ALA LEU LEU ASN ASP ARG PRO          
SEQRES  35 D 1218  GLU PHE VAL ARG LEU LEU ILE SER HIS GLY LEU SER LEU          
SEQRES  36 D 1218  GLY HIS PHE LEU THR PRO MET ARG LEU ALA GLN LEU TYR          
SEQRES  37 D 1218  SER ALA ALA PRO SER ASN SER LEU ILE ARG ASN LEU LEU          
SEQRES  38 D 1218  ASP GLN ALA SER HIS SER ALA GLY THR LYS ALA PRO ALA          
SEQRES  39 D 1218  LEU LYS GLY GLY ALA ALA GLU LEU ARG PRO PRO ASP VAL          
SEQRES  40 D 1218  GLY HIS VAL LEU ARG MET LEU LEU GLY LYS MET CYS ALA          
SEQRES  41 D 1218  PRO ARG TYR PRO SER GLY GLY ALA TRP ASP PRO HIS PRO          
SEQRES  42 D 1218  GLY GLN GLY PHE GLY GLU SER MET TYR LEU LEU SER ASP          
SEQRES  43 D 1218  LYS ALA THR SER PRO LEU SER LEU ASP ALA GLY LEU GLY          
SEQRES  44 D 1218  GLN ALA PRO TRP SER ASP LEU LEU LEU TRP ALA LEU LEU          
SEQRES  45 D 1218  LEU ASN ARG ALA GLN MET ALA MET TYR PHE TRP GLU MET          
SEQRES  46 D 1218  GLY SER ASN ALA VAL SER SER ALA LEU GLY ALA CYS LEU          
SEQRES  47 D 1218  LEU LEU ARG VAL MET ALA ARG LEU GLU PRO ASP ALA GLU          
SEQRES  48 D 1218  GLU ALA ALA ARG ARG LYS ASP LEU ALA PHE LYS PHE GLU          
SEQRES  49 D 1218  GLY MET GLY VAL ASP LEU PHE GLY GLU CYS TYR ARG SER          
SEQRES  50 D 1218  SER GLU VAL ARG ALA ALA ARG LEU LEU LEU ARG ARG CYS          
SEQRES  51 D 1218  PRO LEU TRP GLY ASP ALA THR CYS LEU GLN LEU ALA MET          
SEQRES  52 D 1218  GLN ALA ASP ALA ARG ALA PHE PHE ALA GLN ASP GLY VAL          
SEQRES  53 D 1218  GLN SER LEU LEU THR GLN LYS TRP TRP GLY ASP MET ALA          
SEQRES  54 D 1218  SER THR THR PRO ILE TRP ALA LEU VAL LEU ALA PHE PHE          
SEQRES  55 D 1218  CYS PRO PRO LEU ILE TYR THR ARG LEU ILE THR PHE ARG          
SEQRES  56 D 1218  LYS SER GLU GLU GLU PRO THR ARG GLU GLU LEU GLU PHE          
SEQRES  57 D 1218  ASP MET ASP SER VAL ILE ASN GLY GLU GLY PRO VAL GLY          
SEQRES  58 D 1218  THR ALA ASP PRO ALA GLU LYS THR PRO LEU GLY VAL PRO          
SEQRES  59 D 1218  ARG GLN SER GLY ARG PRO GLY CYS CYS GLY GLY ARG CYS          
SEQRES  60 D 1218  GLY GLY ARG ARG CYS LEU ARG ARG TRP PHE HIS PHE TRP          
SEQRES  61 D 1218  GLY ALA PRO VAL THR ILE PHE MET GLY ASN VAL VAL SER          
SEQRES  62 D 1218  TYR LEU LEU PHE LEU LEU LEU PHE SER ARG VAL LEU LEU          
SEQRES  63 D 1218  VAL ASP PHE GLN PRO ALA PRO PRO GLY SER LEU GLU LEU          
SEQRES  64 D 1218  LEU LEU TYR PHE TRP ALA PHE THR LEU LEU CYS GLU GLU          
SEQRES  65 D 1218  LEU ARG GLN GLY LEU SER GLY GLY GLY GLY SER LEU ALA          
SEQRES  66 D 1218  SER GLY GLY PRO GLY PRO GLY HIS ALA SER LEU SER GLN          
SEQRES  67 D 1218  ARG LEU ARG LEU TYR LEU ALA ASP SER TRP ASN GLN CYS          
SEQRES  68 D 1218  ASP LEU VAL ALA LEU THR CYS PHE LEU LEU GLY VAL GLY          
SEQRES  69 D 1218  CYS ARG LEU THR PRO GLY LEU TYR HIS LEU GLY ARG THR          
SEQRES  70 D 1218  VAL LEU CYS ILE ASP PHE MET VAL PHE THR VAL ARG LEU          
SEQRES  71 D 1218  LEU HIS ILE PHE THR VAL ASN LYS GLN LEU GLY PRO LYS          
SEQRES  72 D 1218  ILE VAL ILE VAL SER LYS MET MET LYS ASP VAL PHE PHE          
SEQRES  73 D 1218  PHE LEU PHE PHE LEU GLY VAL TRP LEU VAL ALA TYR GLY          
SEQRES  74 D 1218  VAL ALA THR GLU GLY LEU LEU ARG PRO ARG ASP SER ASP          
SEQRES  75 D 1218  PHE PRO SER ILE LEU ARG ARG VAL PHE TYR ARG PRO TYR          
SEQRES  76 D 1218  LEU GLN ILE PHE GLY GLN ILE PRO GLN GLU ASP MET ASP          
SEQRES  77 D 1218  VAL ALA LEU MET GLU HIS SER ASN CYS SER SER GLU PRO          
SEQRES  78 D 1218  GLY PHE TRP ALA HIS PRO PRO GLY ALA GLN ALA GLY THR          
SEQRES  79 D 1218  CYS VAL SER GLN TYR ALA ASN TRP LEU VAL VAL LEU LEU          
SEQRES  80 D 1218  LEU VAL ILE PHE LEU LEU VAL ALA ASN ILE LEU LEU VAL          
SEQRES  81 D 1218  ASN LEU LEU ILE ALA MET PHE SER TYR THR PHE GLY LYS          
SEQRES  82 D 1218  VAL GLN GLY ASN SER ASP LEU TYR TRP LYS ALA GLN ARG          
SEQRES  83 D 1218  TYR ARG LEU ILE ARG GLU PHE HIS SER ARG PRO ALA LEU          
SEQRES  84 D 1218  ALA PRO PRO PHE ILE VAL ILE SER HIS LEU ARG LEU LEU          
SEQRES  85 D 1218  LEU ARG GLN LEU CYS ARG ARG PRO ARG SER PRO GLN PRO          
SEQRES  86 D 1218  SER SER PRO ALA LEU GLU HIS PHE ARG VAL TYR LEU SER          
SEQRES  87 D 1218  LYS GLU ALA GLU ARG LYS LEU LEU THR TRP GLU SER VAL          
SEQRES  88 D 1218  HIS LYS GLU ASN PHE LEU LEU ALA ARG ALA ARG ASP LYS          
SEQRES  89 D 1218  ARG GLU SER ASP SER GLU ARG LEU LYS ARG THR SER GLN          
SEQRES  90 D 1218  LYS VAL ASP LEU ALA LEU LYS GLN LEU GLY HIS ILE ARG          
SEQRES  91 D 1218  GLU TYR GLU GLN ARG LEU LYS VAL LEU GLU ARG GLU VAL          
SEQRES  92 D 1218  GLN GLN CYS SER ARG VAL LEU GLY TRP VAL ALA GLU ALA          
SEQRES  93 D 1218  LEU SER ARG SER ALA LEU LEU PRO PRO GLY GLY PRO PRO          
SEQRES  94 D 1218  PRO PRO ASP LEU PRO GLY SER LYS ASP                          
HET     CA  A1300       1                                                       
HET    Y01  A1301      35                                                       
HET    Y01  A1302      35                                                       
HET    Y01  A1303      35                                                       
HET     CA  B1300       1                                                       
HET    Y01  B1301      35                                                       
HET    Y01  B1302      35                                                       
HET    Y01  B1303      35                                                       
HET     CA  C1300       1                                                       
HET    Y01  C1301      35                                                       
HET    Y01  C1302      35                                                       
HET    Y01  C1303      35                                                       
HET     CA  D1300       1                                                       
HET    Y01  D1301      35                                                       
HET    Y01  D1302      35                                                       
HET    Y01  D1303      35                                                       
HETNAM      CA CALCIUM ION                                                      
HETNAM     Y01 CHOLESTEROL HEMISUCCINATE                                        
FORMUL   5   CA    4(CA 2+)                                                     
FORMUL   6  Y01    12(C31 H50 O4)                                               
HELIX    1 AA1 PRO A   99  ARG A  108  1                                  10    
HELIX    2 AA2 GLN A  131  ARG A  140  1                                  10    
HELIX    3 AA3 GLY A  141  GLY A  150  1                                  10    
HELIX    4 AA4 GLY A  161  SER A  177  1                                  17    
HELIX    5 AA5 GLY A  244  GLN A  260  1                                  17    
HELIX    6 AA6 ASP A  281  ALA A  294  1                                  14    
HELIX    7 AA7 ALA A  307  GLU A  316  1                                  10    
HELIX    8 AA8 GLU A  330  PHE A  339  1                                  10    
HELIX    9 AA9 ASP A  343  LYS A  358  1                                  16    
HELIX   10 AB1 GLU A  372  GLY A  386  1                                  15    
HELIX   11 AB2 LEU A  397  TRP A  403  1                                   7    
HELIX   12 AB3 ARG A  405  ARG A  415  1                                  11    
HELIX   13 AB4 ARG A  421  ASN A  435  1                                  15    
HELIX   14 AB5 ARG A  437  HIS A  447  1                                  11    
HELIX   15 AB6 THR A  456  ALA A  466  1                                  11    
HELIX   16 AB7 ILE A  473  SER A  481  1                                   9    
HELIX   17 AB8 GLY A  504  LEU A  510  1                                   7    
HELIX   18 AB9 TRP A  559  LEU A  569  1                                  11    
HELIX   19 AC1 ARG A  571  TRP A  579  1                                   9    
HELIX   20 AC2 ASN A  584  LEU A  602  1                                  19    
HELIX   21 AC3 GLU A  607  SER A  634  1                                  28    
HELIX   22 AC4 SER A  634  LEU A  643  1                                  10    
HELIX   23 AC5 THR A  653  ALA A  661  1                                   9    
HELIX   24 AC6 ALA A  663  ALA A  668  1                                   6    
HELIX   25 AC7 GLN A  669  TRP A  681  1                                  13    
HELIX   26 AC8 PRO A  689  PHE A  698  1                                  10    
HELIX   27 AC9 CYS A  699  THR A  705  5                                   7    
HELIX   28 AD1 CYS A  768  GLY A  777  1                                  10    
HELIX   29 AD2 ALA A  778  ASP A  804  1                                  27    
HELIX   30 AD3 GLY A  811  ARG A  830  1                                  20    
HELIX   31 AD4 SER A  851  LEU A  860  1                                  10    
HELIX   32 AD5 ASP A  862  THR A  884  1                                  23    
HELIX   33 AD6 LEU A  887  PHE A  910  1                                  24    
HELIX   34 AD7 LEU A  916  VAL A  921  1                                   6    
HELIX   35 AD8 MET A  926  LEU A  952  1                                  27    
HELIX   36 AD9 ASP A  958  VAL A  966  1                                   9    
HELIX   37 AE1 PHE A  967  GLN A  973  1                                   7    
HELIX   38 AE2 ILE A  974  GLY A  976  5                                   3    
HELIX   39 AE3 PRO A  979  ASP A  984  1                                   6    
HELIX   40 AE4 VAL A  985  MET A  988  5                                   4    
HELIX   41 AE5 ALA A 1016  ALA A 1031  1                                  16    
HELIX   42 AE6 ILE A 1033  SER A 1071  1                                  39    
HELIX   43 AE7 ARG A 1086  ARG A 1094  1                                   9    
HELIX   44 AE8 SER A 1114  GLU A 1142  1                                  29    
HELIX   45 AE9 SER A 1143  GLU A 1167  1                                  25    
HELIX   46 AF1 GLU A 1167  LEU A 1175  1                                   9    
HELIX   47 AF2 PRO B   99  ARG B  108  1                                  10    
HELIX   48 AF3 GLN B  131  ARG B  140  1                                  10    
HELIX   49 AF4 GLY B  141  GLY B  150  1                                  10    
HELIX   50 AF5 GLY B  161  SER B  177  1                                  17    
HELIX   51 AF6 GLY B  244  GLN B  260  1                                  17    
HELIX   52 AF7 ASP B  281  ALA B  294  1                                  14    
HELIX   53 AF8 ALA B  307  GLU B  316  1                                  10    
HELIX   54 AF9 GLU B  330  PHE B  339  1                                  10    
HELIX   55 AG1 ASP B  343  LYS B  358  1                                  16    
HELIX   56 AG2 GLU B  372  GLY B  386  1                                  15    
HELIX   57 AG3 LEU B  397  TRP B  403  1                                   7    
HELIX   58 AG4 ARG B  405  ARG B  415  1                                  11    
HELIX   59 AG5 ARG B  421  ASN B  435  1                                  15    
HELIX   60 AG6 ARG B  437  HIS B  447  1                                  11    
HELIX   61 AG7 THR B  456  ALA B  466  1                                  11    
HELIX   62 AG8 ILE B  473  SER B  481  1                                   9    
HELIX   63 AG9 GLY B  504  LEU B  510  1                                   7    
HELIX   64 AH1 TRP B  559  LEU B  569  1                                  11    
HELIX   65 AH2 ARG B  571  TRP B  579  1                                   9    
HELIX   66 AH3 ASN B  584  LEU B  602  1                                  19    
HELIX   67 AH4 GLU B  607  SER B  634  1                                  28    
HELIX   68 AH5 SER B  634  LEU B  643  1                                  10    
HELIX   69 AH6 THR B  653  ALA B  661  1                                   9    
HELIX   70 AH7 ALA B  663  ALA B  668  1                                   6    
HELIX   71 AH8 GLN B  669  TRP B  681  1                                  13    
HELIX   72 AH9 PRO B  689  PHE B  698  1                                  10    
HELIX   73 AI1 CYS B  699  THR B  705  5                                   7    
HELIX   74 AI2 CYS B  768  GLY B  777  1                                  10    
HELIX   75 AI3 ALA B  778  ASP B  804  1                                  27    
HELIX   76 AI4 GLY B  811  ARG B  830  1                                  20    
HELIX   77 AI5 SER B  851  LEU B  860  1                                  10    
HELIX   78 AI6 ASP B  862  THR B  884  1                                  23    
HELIX   79 AI7 LEU B  887  PHE B  910  1                                  24    
HELIX   80 AI8 LEU B  916  VAL B  921  1                                   6    
HELIX   81 AI9 MET B  926  LEU B  952  1                                  27    
HELIX   82 AJ1 ASP B  958  VAL B  966  1                                   9    
HELIX   83 AJ2 PHE B  967  GLN B  973  1                                   7    
HELIX   84 AJ3 ILE B  974  GLY B  976  5                                   3    
HELIX   85 AJ4 PRO B  979  ASP B  984  1                                   6    
HELIX   86 AJ5 VAL B  985  MET B  988  5                                   4    
HELIX   87 AJ6 ALA B 1016  ALA B 1031  1                                  16    
HELIX   88 AJ7 ILE B 1033  SER B 1071  1                                  39    
HELIX   89 AJ8 ARG B 1086  ARG B 1094  1                                   9    
HELIX   90 AJ9 SER B 1114  GLU B 1142  1                                  29    
HELIX   91 AK1 SER B 1143  GLU B 1167  1                                  25    
HELIX   92 AK2 GLU B 1167  LEU B 1175  1                                   9    
HELIX   93 AK3 PRO C   99  ARG C  108  1                                  10    
HELIX   94 AK4 GLN C  131  ARG C  140  1                                  10    
HELIX   95 AK5 GLY C  141  GLY C  150  1                                  10    
HELIX   96 AK6 GLY C  161  SER C  177  1                                  17    
HELIX   97 AK7 GLY C  244  GLN C  260  1                                  17    
HELIX   98 AK8 ASP C  281  ALA C  294  1                                  14    
HELIX   99 AK9 ALA C  307  GLU C  316  1                                  10    
HELIX  100 AL1 GLU C  330  PHE C  339  1                                  10    
HELIX  101 AL2 ASP C  343  LYS C  358  1                                  16    
HELIX  102 AL3 GLU C  372  GLY C  386  1                                  15    
HELIX  103 AL4 LEU C  397  TRP C  403  1                                   7    
HELIX  104 AL5 ARG C  405  ARG C  415  1                                  11    
HELIX  105 AL6 ARG C  421  ASN C  435  1                                  15    
HELIX  106 AL7 ARG C  437  HIS C  447  1                                  11    
HELIX  107 AL8 THR C  456  ALA C  466  1                                  11    
HELIX  108 AL9 ILE C  473  SER C  481  1                                   9    
HELIX  109 AM1 GLY C  504  LEU C  510  1                                   7    
HELIX  110 AM2 TRP C  559  LEU C  569  1                                  11    
HELIX  111 AM3 ARG C  571  TRP C  579  1                                   9    
HELIX  112 AM4 ASN C  584  LEU C  602  1                                  19    
HELIX  113 AM5 GLU C  607  SER C  634  1                                  28    
HELIX  114 AM6 SER C  634  LEU C  643  1                                  10    
HELIX  115 AM7 THR C  653  ALA C  661  1                                   9    
HELIX  116 AM8 ALA C  663  ALA C  668  1                                   6    
HELIX  117 AM9 GLN C  669  TRP C  681  1                                  13    
HELIX  118 AN1 PRO C  689  PHE C  698  1                                  10    
HELIX  119 AN2 CYS C  699  THR C  705  5                                   7    
HELIX  120 AN3 CYS C  768  GLY C  777  1                                  10    
HELIX  121 AN4 ALA C  778  ASP C  804  1                                  27    
HELIX  122 AN5 GLY C  811  ARG C  830  1                                  20    
HELIX  123 AN6 SER C  851  LEU C  860  1                                  10    
HELIX  124 AN7 ASP C  862  THR C  884  1                                  23    
HELIX  125 AN8 LEU C  887  PHE C  910  1                                  24    
HELIX  126 AN9 LEU C  916  VAL C  921  1                                   6    
HELIX  127 AO1 MET C  926  LEU C  952  1                                  27    
HELIX  128 AO2 ASP C  958  VAL C  966  1                                   9    
HELIX  129 AO3 PHE C  967  GLN C  973  1                                   7    
HELIX  130 AO4 ILE C  974  GLY C  976  5                                   3    
HELIX  131 AO5 PRO C  979  ASP C  984  1                                   6    
HELIX  132 AO6 VAL C  985  MET C  988  5                                   4    
HELIX  133 AO7 ALA C 1016  ALA C 1031  1                                  16    
HELIX  134 AO8 ILE C 1033  SER C 1071  1                                  39    
HELIX  135 AO9 ARG C 1086  ARG C 1094  1                                   9    
HELIX  136 AP1 SER C 1114  GLU C 1142  1                                  29    
HELIX  137 AP2 SER C 1143  GLU C 1167  1                                  25    
HELIX  138 AP3 GLU C 1167  LEU C 1175  1                                   9    
HELIX  139 AP4 PRO D   99  ARG D  108  1                                  10    
HELIX  140 AP5 GLN D  131  ARG D  140  1                                  10    
HELIX  141 AP6 GLY D  141  GLY D  150  1                                  10    
HELIX  142 AP7 GLY D  161  SER D  177  1                                  17    
HELIX  143 AP8 GLY D  244  GLN D  260  1                                  17    
HELIX  144 AP9 ASP D  281  ALA D  294  1                                  14    
HELIX  145 AQ1 ALA D  307  GLU D  316  1                                  10    
HELIX  146 AQ2 GLU D  330  PHE D  339  1                                  10    
HELIX  147 AQ3 ASP D  343  LYS D  358  1                                  16    
HELIX  148 AQ4 GLU D  372  GLY D  386  1                                  15    
HELIX  149 AQ5 LEU D  397  TRP D  403  1                                   7    
HELIX  150 AQ6 ARG D  405  ARG D  415  1                                  11    
HELIX  151 AQ7 ARG D  421  ASN D  435  1                                  15    
HELIX  152 AQ8 ARG D  437  HIS D  447  1                                  11    
HELIX  153 AQ9 THR D  456  ALA D  466  1                                  11    
HELIX  154 AR1 ILE D  473  SER D  481  1                                   9    
HELIX  155 AR2 GLY D  504  LEU D  510  1                                   7    
HELIX  156 AR3 TRP D  559  LEU D  569  1                                  11    
HELIX  157 AR4 ARG D  571  TRP D  579  1                                   9    
HELIX  158 AR5 ASN D  584  LEU D  602  1                                  19    
HELIX  159 AR6 GLU D  607  SER D  634  1                                  28    
HELIX  160 AR7 SER D  634  LEU D  643  1                                  10    
HELIX  161 AR8 THR D  653  ALA D  661  1                                   9    
HELIX  162 AR9 ALA D  663  ALA D  668  1                                   6    
HELIX  163 AS1 GLN D  669  TRP D  681  1                                  13    
HELIX  164 AS2 PRO D  689  PHE D  698  1                                  10    
HELIX  165 AS3 CYS D  699  THR D  705  5                                   7    
HELIX  166 AS4 CYS D  768  GLY D  777  1                                  10    
HELIX  167 AS5 ALA D  778  ASP D  804  1                                  27    
HELIX  168 AS6 GLY D  811  ARG D  830  1                                  20    
HELIX  169 AS7 SER D  851  LEU D  860  1                                  10    
HELIX  170 AS8 ASP D  862  THR D  884  1                                  23    
HELIX  171 AS9 LEU D  887  PHE D  910  1                                  24    
HELIX  172 AT1 LEU D  916  VAL D  921  1                                   6    
HELIX  173 AT2 MET D  926  LEU D  952  1                                  27    
HELIX  174 AT3 ASP D  958  VAL D  966  1                                   9    
HELIX  175 AT4 PHE D  967  GLN D  973  1                                   7    
HELIX  176 AT5 ILE D  974  GLY D  976  5                                   3    
HELIX  177 AT6 PRO D  979  ASP D  984  1                                   6    
HELIX  178 AT7 VAL D  985  MET D  988  5                                   4    
HELIX  179 AT8 ALA D 1016  ALA D 1031  1                                  16    
HELIX  180 AT9 ILE D 1033  SER D 1071  1                                  39    
HELIX  181 AU1 ARG D 1086  ARG D 1094  1                                   9    
HELIX  182 AU2 SER D 1114  GLU D 1142  1                                  29    
HELIX  183 AU3 SER D 1143  GLU D 1167  1                                  25    
HELIX  184 AU4 GLU D 1167  LEU D 1175  1                                   9    
SHEET    1 AA1 2 ASN A  89  LEU A  93  0                                        
SHEET    2 AA1 2 ALA A 231  VAL A 235  1  O  LEU A 234   N  LEU A  91           
SHEET    1 AA2 6 ALA A 185  GLY A 187  0                                        
SHEET    2 AA2 6 TRP A 152  THR A 155  1  N  THR A 155   O  MET A 186           
SHEET    3 AA2 6 VAL A 118  LEU A 122  1  N  VAL A 121   O  VAL A 154           
SHEET    4 AA2 6 VAL A 273  LEU A 277  1  O  LEU A 276   N  SER A 120           
SHEET    5 AA2 6 CYS A 298  VAL A 301  1  O  LEU A 299   N  LEU A 275           
SHEET    6 AA2 6 LEU A 361  TYR A 364  1  O  TYR A 364   N  LEU A 300           
SHEET    1 AA3 2 LYS A 261  THR A 262  0                                        
SHEET    2 AA3 2 ILE A 269  ASP A 270 -1  O  ILE A 269   N  THR A 262           
SHEET    1 AA4 2 TRP A1000  ALA A1001  0                                        
SHEET    2 AA4 2 VAL A1012  SER A1013 -1  O  VAL A1012   N  ALA A1001           
SHEET    1 AA5 2 ASN B  89  LEU B  93  0                                        
SHEET    2 AA5 2 ALA B 231  VAL B 235  1  O  LEU B 234   N  LEU B  91           
SHEET    1 AA6 6 ALA B 185  GLY B 187  0                                        
SHEET    2 AA6 6 TRP B 152  THR B 155  1  N  THR B 155   O  MET B 186           
SHEET    3 AA6 6 VAL B 118  LEU B 122  1  N  VAL B 121   O  VAL B 154           
SHEET    4 AA6 6 VAL B 273  LEU B 277  1  O  LEU B 276   N  SER B 120           
SHEET    5 AA6 6 CYS B 298  VAL B 301  1  O  LEU B 299   N  LEU B 275           
SHEET    6 AA6 6 LEU B 361  TYR B 364  1  O  TYR B 364   N  LEU B 300           
SHEET    1 AA7 2 LYS B 261  THR B 262  0                                        
SHEET    2 AA7 2 ILE B 269  ASP B 270 -1  O  ILE B 269   N  THR B 262           
SHEET    1 AA8 2 TRP B1000  ALA B1001  0                                        
SHEET    2 AA8 2 VAL B1012  SER B1013 -1  O  VAL B1012   N  ALA B1001           
SHEET    1 AA9 2 ASN C  89  LEU C  93  0                                        
SHEET    2 AA9 2 ALA C 231  VAL C 235  1  O  LEU C 234   N  LEU C  91           
SHEET    1 AB1 6 ALA C 185  GLY C 187  0                                        
SHEET    2 AB1 6 TRP C 152  THR C 155  1  N  THR C 155   O  MET C 186           
SHEET    3 AB1 6 VAL C 118  LEU C 122  1  N  VAL C 121   O  VAL C 154           
SHEET    4 AB1 6 VAL C 273  LEU C 277  1  O  LEU C 276   N  SER C 120           
SHEET    5 AB1 6 CYS C 298  VAL C 301  1  O  LEU C 299   N  LEU C 275           
SHEET    6 AB1 6 LEU C 361  TYR C 364  1  O  TYR C 364   N  LEU C 300           
SHEET    1 AB2 2 LYS C 261  THR C 262  0                                        
SHEET    2 AB2 2 ILE C 269  ASP C 270 -1  O  ILE C 269   N  THR C 262           
SHEET    1 AB3 2 TRP C1000  ALA C1001  0                                        
SHEET    2 AB3 2 VAL C1012  SER C1013 -1  O  VAL C1012   N  ALA C1001           
SHEET    1 AB4 2 ASN D  89  LEU D  93  0                                        
SHEET    2 AB4 2 ALA D 231  VAL D 235  1  O  LEU D 234   N  LEU D  91           
SHEET    1 AB5 6 ALA D 185  GLY D 187  0                                        
SHEET    2 AB5 6 TRP D 152  THR D 155  1  N  THR D 155   O  MET D 186           
SHEET    3 AB5 6 VAL D 118  LEU D 122  1  N  VAL D 121   O  VAL D 154           
SHEET    4 AB5 6 VAL D 273  LEU D 277  1  O  LEU D 276   N  SER D 120           
SHEET    5 AB5 6 CYS D 298  VAL D 301  1  O  LEU D 299   N  LEU D 275           
SHEET    6 AB5 6 LEU D 361  TYR D 364  1  O  TYR D 364   N  LEU D 300           
SHEET    1 AB6 2 LYS D 261  THR D 262  0                                        
SHEET    2 AB6 2 ILE D 269  ASP D 270 -1  O  ILE D 269   N  THR D 262           
SHEET    1 AB7 2 TRP D1000  ALA D1001  0                                        
SHEET    2 AB7 2 VAL D1012  SER D1013 -1  O  VAL D1012   N  ALA D1001           
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system