GenomeNet

Database: PDB
Entry: 6C3O
LinkDB: 6C3O
Original site: 6C3O 
HEADER    TRANSPORT PROTEIN                       10-JAN-18   6C3O              
TITLE     CRYO-EM STRUCTURE OF HUMAN KATP BOUND TO ATP AND ADP IN QUATREFOIL    
TITLE    2 FORM                                                                 
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 11;       
COMPND   3 CHAIN: A, C, B, D;                                                   
COMPND   4 SYNONYM: IKATP,INWARD RECTIFIER K(+) CHANNEL KIR6.2,POTASSIUM        
COMPND   5 CHANNEL,INWARDLY RECTIFYING SUBFAMILY J MEMBER 11;                   
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8;                
COMPND   9 CHAIN: E, H, G, F;                                                   
COMPND  10 SYNONYM: SULFONYLUREA RECEPTOR 1;                                    
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: KCNJ11;                                                        
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: ABCC8, HRINS, SUR, SUR1;                                       
SOURCE  13 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    ATP-DEPENDENT POTASSIUM CHANNEL KIR6.2 SUR1 ATP ADP, TRANSPORT        
KEYWDS   2 PROTEIN                                                              
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    K.P.K.LEE,J.CHEN,R.MACKINNON                                          
REVDAT   1   31-JAN-18 6C3O    0                                                
JRNL        AUTH   K.P.K.LEE,J.CHEN,R.MACKINNON                                 
JRNL        TITL   MOLECULAR STRUCTURE OF HUMAN KATP IN COMPLEX WITH ATP AND    
JRNL        TITL 2 ADP                                                          
JRNL        REF    ELIFE                         V.   6       2017              
JRNL        REFN                   ESSN 2050-084X                               
JRNL        PMID   29286281                                                     
JRNL        DOI    10.7554/ELIFE.32481                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : EMAN2, SERIALEM, CTFFIND, CRYOSPARC,      
REMARK   3                            RELION, RELION, RELION                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.900                          
REMARK   3   NUMBER OF PARTICLES               : 47282                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6C3O COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 12-JAN-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000231904.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : QUATREFOIL FORM OF HUMAN KATP     
REMARK 245                                    IN COMPLEX WITH ATP AND ADP       
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.45                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 1.18                           
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, B, D, E, H, G, F                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     SER A    -5                                                      
REMARK 465     ALA A    -4                                                      
REMARK 465     SER A    -3                                                      
REMARK 465     ALA A    -2                                                      
REMARK 465     SER A    -1                                                      
REMARK 465     ALA A     0                                                      
REMARK 465     MET A     1                                                      
REMARK 465     LEU A     2                                                      
REMARK 465     SER A     3                                                      
REMARK 465     ARG A     4                                                      
REMARK 465     LYS A     5                                                      
REMARK 465     GLY A     6                                                      
REMARK 465     ILE A     7                                                      
REMARK 465     ILE A     8                                                      
REMARK 465     PRO A     9                                                      
REMARK 465     GLU A    10                                                      
REMARK 465     GLU A    11                                                      
REMARK 465     TYR A    12                                                      
REMARK 465     VAL A    13                                                      
REMARK 465     LEU A    14                                                      
REMARK 465     THR A    15                                                      
REMARK 465     ARG A    16                                                      
REMARK 465     LEU A    17                                                      
REMARK 465     ALA A    18                                                      
REMARK 465     GLU A    19                                                      
REMARK 465     ASP A    20                                                      
REMARK 465     PRO A    21                                                      
REMARK 465     ALA A    22                                                      
REMARK 465     GLU A    23                                                      
REMARK 465     PRO A    24                                                      
REMARK 465     ARG A    25                                                      
REMARK 465     TYR A    26                                                      
REMARK 465     ARG A    27                                                      
REMARK 465     ALA A    28                                                      
REMARK 465     ARG A    29                                                      
REMARK 465     GLN A    30                                                      
REMARK 465     ARG A    31                                                      
REMARK 465     THR A   360                                                      
REMARK 465     LEU A   361                                                      
REMARK 465     ALA A   362                                                      
REMARK 465     SER A   363                                                      
REMARK 465     ALA A   364                                                      
REMARK 465     ARG A   365                                                      
REMARK 465     GLY A   366                                                      
REMARK 465     PRO A   367                                                      
REMARK 465     LEU A   368                                                      
REMARK 465     ARG A   369                                                      
REMARK 465     LYS A   370                                                      
REMARK 465     ARG A   371                                                      
REMARK 465     SER A   372                                                      
REMARK 465     VAL A   373                                                      
REMARK 465     PRO A   374                                                      
REMARK 465     MET A   375                                                      
REMARK 465     ALA A   376                                                      
REMARK 465     LYS A   377                                                      
REMARK 465     ALA A   378                                                      
REMARK 465     LYS A   379                                                      
REMARK 465     PRO A   380                                                      
REMARK 465     LYS A   381                                                      
REMARK 465     PHE A   382                                                      
REMARK 465     SER A   383                                                      
REMARK 465     ILE A   384                                                      
REMARK 465     SER A   385                                                      
REMARK 465     PRO A   386                                                      
REMARK 465     ASP A   387                                                      
REMARK 465     SER A   388                                                      
REMARK 465     LEU A   389                                                      
REMARK 465     SER A   390                                                      
REMARK 465     SER A   391                                                      
REMARK 465     ASN A   392                                                      
REMARK 465     SER A   393                                                      
REMARK 465     LEU A   394                                                      
REMARK 465     GLU A   395                                                      
REMARK 465     VAL A   396                                                      
REMARK 465     LEU A   397                                                      
REMARK 465     PHE A   398                                                      
REMARK 465     GLN A   399                                                      
REMARK 465     GLY A   400                                                      
REMARK 465     SER C    -5                                                      
REMARK 465     ALA C    -4                                                      
REMARK 465     SER C    -3                                                      
REMARK 465     ALA C    -2                                                      
REMARK 465     SER C    -1                                                      
REMARK 465     ALA C     0                                                      
REMARK 465     MET C     1                                                      
REMARK 465     LEU C     2                                                      
REMARK 465     SER C     3                                                      
REMARK 465     ARG C     4                                                      
REMARK 465     LYS C     5                                                      
REMARK 465     GLY C     6                                                      
REMARK 465     ILE C     7                                                      
REMARK 465     ILE C     8                                                      
REMARK 465     PRO C     9                                                      
REMARK 465     GLU C    10                                                      
REMARK 465     GLU C    11                                                      
REMARK 465     TYR C    12                                                      
REMARK 465     VAL C    13                                                      
REMARK 465     LEU C    14                                                      
REMARK 465     THR C    15                                                      
REMARK 465     ARG C    16                                                      
REMARK 465     LEU C    17                                                      
REMARK 465     ALA C    18                                                      
REMARK 465     GLU C    19                                                      
REMARK 465     ASP C    20                                                      
REMARK 465     PRO C    21                                                      
REMARK 465     ALA C    22                                                      
REMARK 465     GLU C    23                                                      
REMARK 465     PRO C    24                                                      
REMARK 465     ARG C    25                                                      
REMARK 465     TYR C    26                                                      
REMARK 465     ARG C    27                                                      
REMARK 465     ALA C    28                                                      
REMARK 465     ARG C    29                                                      
REMARK 465     GLN C    30                                                      
REMARK 465     ARG C    31                                                      
REMARK 465     THR C   360                                                      
REMARK 465     LEU C   361                                                      
REMARK 465     ALA C   362                                                      
REMARK 465     SER C   363                                                      
REMARK 465     ALA C   364                                                      
REMARK 465     ARG C   365                                                      
REMARK 465     GLY C   366                                                      
REMARK 465     PRO C   367                                                      
REMARK 465     LEU C   368                                                      
REMARK 465     ARG C   369                                                      
REMARK 465     LYS C   370                                                      
REMARK 465     ARG C   371                                                      
REMARK 465     SER C   372                                                      
REMARK 465     VAL C   373                                                      
REMARK 465     PRO C   374                                                      
REMARK 465     MET C   375                                                      
REMARK 465     ALA C   376                                                      
REMARK 465     LYS C   377                                                      
REMARK 465     ALA C   378                                                      
REMARK 465     LYS C   379                                                      
REMARK 465     PRO C   380                                                      
REMARK 465     LYS C   381                                                      
REMARK 465     PHE C   382                                                      
REMARK 465     SER C   383                                                      
REMARK 465     ILE C   384                                                      
REMARK 465     SER C   385                                                      
REMARK 465     PRO C   386                                                      
REMARK 465     ASP C   387                                                      
REMARK 465     SER C   388                                                      
REMARK 465     LEU C   389                                                      
REMARK 465     SER C   390                                                      
REMARK 465     SER C   391                                                      
REMARK 465     ASN C   392                                                      
REMARK 465     SER C   393                                                      
REMARK 465     LEU C   394                                                      
REMARK 465     GLU C   395                                                      
REMARK 465     VAL C   396                                                      
REMARK 465     LEU C   397                                                      
REMARK 465     PHE C   398                                                      
REMARK 465     GLN C   399                                                      
REMARK 465     GLY C   400                                                      
REMARK 465     SER B    -5                                                      
REMARK 465     ALA B    -4                                                      
REMARK 465     SER B    -3                                                      
REMARK 465     ALA B    -2                                                      
REMARK 465     SER B    -1                                                      
REMARK 465     ALA B     0                                                      
REMARK 465     MET B     1                                                      
REMARK 465     LEU B     2                                                      
REMARK 465     SER B     3                                                      
REMARK 465     ARG B     4                                                      
REMARK 465     LYS B     5                                                      
REMARK 465     GLY B     6                                                      
REMARK 465     ILE B     7                                                      
REMARK 465     ILE B     8                                                      
REMARK 465     PRO B     9                                                      
REMARK 465     GLU B    10                                                      
REMARK 465     GLU B    11                                                      
REMARK 465     TYR B    12                                                      
REMARK 465     VAL B    13                                                      
REMARK 465     LEU B    14                                                      
REMARK 465     THR B    15                                                      
REMARK 465     ARG B    16                                                      
REMARK 465     LEU B    17                                                      
REMARK 465     ALA B    18                                                      
REMARK 465     GLU B    19                                                      
REMARK 465     ASP B    20                                                      
REMARK 465     PRO B    21                                                      
REMARK 465     ALA B    22                                                      
REMARK 465     GLU B    23                                                      
REMARK 465     PRO B    24                                                      
REMARK 465     ARG B    25                                                      
REMARK 465     TYR B    26                                                      
REMARK 465     ARG B    27                                                      
REMARK 465     ALA B    28                                                      
REMARK 465     ARG B    29                                                      
REMARK 465     GLN B    30                                                      
REMARK 465     ARG B    31                                                      
REMARK 465     THR B   360                                                      
REMARK 465     LEU B   361                                                      
REMARK 465     ALA B   362                                                      
REMARK 465     SER B   363                                                      
REMARK 465     ALA B   364                                                      
REMARK 465     ARG B   365                                                      
REMARK 465     GLY B   366                                                      
REMARK 465     PRO B   367                                                      
REMARK 465     LEU B   368                                                      
REMARK 465     ARG B   369                                                      
REMARK 465     LYS B   370                                                      
REMARK 465     ARG B   371                                                      
REMARK 465     SER B   372                                                      
REMARK 465     VAL B   373                                                      
REMARK 465     PRO B   374                                                      
REMARK 465     MET B   375                                                      
REMARK 465     ALA B   376                                                      
REMARK 465     LYS B   377                                                      
REMARK 465     ALA B   378                                                      
REMARK 465     LYS B   379                                                      
REMARK 465     PRO B   380                                                      
REMARK 465     LYS B   381                                                      
REMARK 465     PHE B   382                                                      
REMARK 465     SER B   383                                                      
REMARK 465     ILE B   384                                                      
REMARK 465     SER B   385                                                      
REMARK 465     PRO B   386                                                      
REMARK 465     ASP B   387                                                      
REMARK 465     SER B   388                                                      
REMARK 465     LEU B   389                                                      
REMARK 465     SER B   390                                                      
REMARK 465     SER B   391                                                      
REMARK 465     ASN B   392                                                      
REMARK 465     SER B   393                                                      
REMARK 465     LEU B   394                                                      
REMARK 465     GLU B   395                                                      
REMARK 465     VAL B   396                                                      
REMARK 465     LEU B   397                                                      
REMARK 465     PHE B   398                                                      
REMARK 465     GLN B   399                                                      
REMARK 465     GLY B   400                                                      
REMARK 465     SER D    -5                                                      
REMARK 465     ALA D    -4                                                      
REMARK 465     SER D    -3                                                      
REMARK 465     ALA D    -2                                                      
REMARK 465     SER D    -1                                                      
REMARK 465     ALA D     0                                                      
REMARK 465     MET D     1                                                      
REMARK 465     LEU D     2                                                      
REMARK 465     SER D     3                                                      
REMARK 465     ARG D     4                                                      
REMARK 465     LYS D     5                                                      
REMARK 465     GLY D     6                                                      
REMARK 465     ILE D     7                                                      
REMARK 465     ILE D     8                                                      
REMARK 465     PRO D     9                                                      
REMARK 465     GLU D    10                                                      
REMARK 465     GLU D    11                                                      
REMARK 465     TYR D    12                                                      
REMARK 465     VAL D    13                                                      
REMARK 465     LEU D    14                                                      
REMARK 465     THR D    15                                                      
REMARK 465     ARG D    16                                                      
REMARK 465     LEU D    17                                                      
REMARK 465     ALA D    18                                                      
REMARK 465     GLU D    19                                                      
REMARK 465     ASP D    20                                                      
REMARK 465     PRO D    21                                                      
REMARK 465     ALA D    22                                                      
REMARK 465     GLU D    23                                                      
REMARK 465     PRO D    24                                                      
REMARK 465     ARG D    25                                                      
REMARK 465     TYR D    26                                                      
REMARK 465     ARG D    27                                                      
REMARK 465     ALA D    28                                                      
REMARK 465     ARG D    29                                                      
REMARK 465     GLN D    30                                                      
REMARK 465     ARG D    31                                                      
REMARK 465     THR D   360                                                      
REMARK 465     LEU D   361                                                      
REMARK 465     ALA D   362                                                      
REMARK 465     SER D   363                                                      
REMARK 465     ALA D   364                                                      
REMARK 465     ARG D   365                                                      
REMARK 465     GLY D   366                                                      
REMARK 465     PRO D   367                                                      
REMARK 465     LEU D   368                                                      
REMARK 465     ARG D   369                                                      
REMARK 465     LYS D   370                                                      
REMARK 465     ARG D   371                                                      
REMARK 465     SER D   372                                                      
REMARK 465     VAL D   373                                                      
REMARK 465     PRO D   374                                                      
REMARK 465     MET D   375                                                      
REMARK 465     ALA D   376                                                      
REMARK 465     LYS D   377                                                      
REMARK 465     ALA D   378                                                      
REMARK 465     LYS D   379                                                      
REMARK 465     PRO D   380                                                      
REMARK 465     LYS D   381                                                      
REMARK 465     PHE D   382                                                      
REMARK 465     SER D   383                                                      
REMARK 465     ILE D   384                                                      
REMARK 465     SER D   385                                                      
REMARK 465     PRO D   386                                                      
REMARK 465     ASP D   387                                                      
REMARK 465     SER D   388                                                      
REMARK 465     LEU D   389                                                      
REMARK 465     SER D   390                                                      
REMARK 465     SER D   391                                                      
REMARK 465     ASN D   392                                                      
REMARK 465     SER D   393                                                      
REMARK 465     LEU D   394                                                      
REMARK 465     GLU D   395                                                      
REMARK 465     VAL D   396                                                      
REMARK 465     LEU D   397                                                      
REMARK 465     PHE D   398                                                      
REMARK 465     GLN D   399                                                      
REMARK 465     GLY D   400                                                      
REMARK 465     MET E     1                                                      
REMARK 465     SER E    53                                                      
REMARK 465     GLN E    54                                                      
REMARK 465     SER E    55                                                      
REMARK 465     SER E    56                                                      
REMARK 465     LYS E    57                                                      
REMARK 465     VAL E    58                                                      
REMARK 465     HIS E    59                                                      
REMARK 465     ILE E    60                                                      
REMARK 465     HIS E    61                                                      
REMARK 465     HIS E    62                                                      
REMARK 465     SER E    63                                                      
REMARK 465     THR E    64                                                      
REMARK 465     TRP E    65                                                      
REMARK 465     LEU E    66                                                      
REMARK 465     HIS E    67                                                      
REMARK 465     ARG E   193                                                      
REMARK 465     ARG E   194                                                      
REMARK 465     TYR E   195                                                      
REMARK 465     ILE E   196                                                      
REMARK 465     PHE E   197                                                      
REMARK 465     PHE E   198                                                      
REMARK 465     LYS E   199                                                      
REMARK 465     THR E   200                                                      
REMARK 465     PRO E   201                                                      
REMARK 465     ARG E   202                                                      
REMARK 465     GLU E   203                                                      
REMARK 465     VAL E   204                                                      
REMARK 465     LYS E   205                                                      
REMARK 465     PRO E   206                                                      
REMARK 465     PRO E   207                                                      
REMARK 465     GLU E   208                                                      
REMARK 465     ASP E   209                                                      
REMARK 465     LEU E   210                                                      
REMARK 465     GLN E   211                                                      
REMARK 465     ASP E   212                                                      
REMARK 465     LEU E   213                                                      
REMARK 465     GLY E   214                                                      
REMARK 465     VAL E   215                                                      
REMARK 465     ARG E   216                                                      
REMARK 465     PHE E   217                                                      
REMARK 465     LEU E   218                                                      
REMARK 465     GLN E   219                                                      
REMARK 465     PRO E   220                                                      
REMARK 465     PHE E   221                                                      
REMARK 465     VAL E   222                                                      
REMARK 465     ASN E   223                                                      
REMARK 465     LEU E   224                                                      
REMARK 465     LEU E   225                                                      
REMARK 465     SER E   226                                                      
REMARK 465     LYS E   227                                                      
REMARK 465     GLY E   228                                                      
REMARK 465     THR E   229                                                      
REMARK 465     TYR E   230                                                      
REMARK 465     TRP E   231                                                      
REMARK 465     TRP E   232                                                      
REMARK 465     MET E   233                                                      
REMARK 465     ASN E   234                                                      
REMARK 465     ALA E   235                                                      
REMARK 465     PHE E   236                                                      
REMARK 465     ILE E   237                                                      
REMARK 465     LYS E   238                                                      
REMARK 465     THR E   239                                                      
REMARK 465     ALA E   240                                                      
REMARK 465     HIS E   241                                                      
REMARK 465     LYS E   242                                                      
REMARK 465     LYS E   243                                                      
REMARK 465     PRO E   244                                                      
REMARK 465     ILE E   245                                                      
REMARK 465     ASP E   246                                                      
REMARK 465     LEU E   247                                                      
REMARK 465     ARG E   248                                                      
REMARK 465     ALA E   249                                                      
REMARK 465     ILE E   250                                                      
REMARK 465     GLY E   251                                                      
REMARK 465     LYS E   252                                                      
REMARK 465     LEU E   253                                                      
REMARK 465     PRO E   254                                                      
REMARK 465     ILE E   255                                                      
REMARK 465     ALA E   256                                                      
REMARK 465     MET E   257                                                      
REMARK 465     ARG E   258                                                      
REMARK 465     ALA E   259                                                      
REMARK 465     LEU E   260                                                      
REMARK 465     THR E   261                                                      
REMARK 465     ILE E   278                                                      
REMARK 465     GLN E   279                                                      
REMARK 465     GLY E   280                                                      
REMARK 465     THR E   281                                                      
REMARK 465     GLN E   282                                                      
REMARK 465     GLY E   283                                                      
REMARK 465     ALA E   284                                                      
REMARK 465     ARG E   285                                                      
REMARK 465     GLU E   330                                                      
REMARK 465     ASN E   331                                                      
REMARK 465     ASP E   332                                                      
REMARK 465     VAL E   333                                                      
REMARK 465     PHE E   334                                                      
REMARK 465     GLN E   335                                                      
REMARK 465     PRO E   336                                                      
REMARK 465     LYS E   337                                                      
REMARK 465     THR E   338                                                      
REMARK 465     GLN E   339                                                      
REMARK 465     PHE E   340                                                      
REMARK 465     LEU E   341                                                      
REMARK 465     GLY E   342                                                      
REMARK 465     VAL E   343                                                      
REMARK 465     TYR E   344                                                      
REMARK 465     PHE E   345                                                      
REMARK 465     VAL E   346                                                      
REMARK 465     SER E   347                                                      
REMARK 465     SER E   348                                                      
REMARK 465     GLN E   349                                                      
REMARK 465     GLU E   350                                                      
REMARK 465     PHE E   351                                                      
REMARK 465     LEU E   352                                                      
REMARK 465     SER E   564                                                      
REMARK 465     PHE E   565                                                      
REMARK 465     PHE E   566                                                      
REMARK 465     LYS E   567                                                      
REMARK 465     GLU E   568                                                      
REMARK 465     ALA E   569                                                      
REMARK 465     ASP E   570                                                      
REMARK 465     PHE E   571                                                      
REMARK 465     SER E   572                                                      
REMARK 465     GLU E   621                                                      
REMARK 465     GLU E   622                                                      
REMARK 465     GLN E   623                                                      
REMARK 465     CYS E   624                                                      
REMARK 465     ALA E   625                                                      
REMARK 465     PRO E   626                                                      
REMARK 465     HIS E   627                                                      
REMARK 465     GLU E   628                                                      
REMARK 465     PRO E   629                                                      
REMARK 465     THR E   630                                                      
REMARK 465     PRO E   631                                                      
REMARK 465     GLN E   632                                                      
REMARK 465     GLY E   633                                                      
REMARK 465     PRO E   634                                                      
REMARK 465     ALA E   635                                                      
REMARK 465     SER E   636                                                      
REMARK 465     LYS E   637                                                      
REMARK 465     TYR E   638                                                      
REMARK 465     GLN E   639                                                      
REMARK 465     ALA E   640                                                      
REMARK 465     VAL E   641                                                      
REMARK 465     PRO E   642                                                      
REMARK 465     LEU E   643                                                      
REMARK 465     ARG E   644                                                      
REMARK 465     VAL E   645                                                      
REMARK 465     VAL E   646                                                      
REMARK 465     ASN E   647                                                      
REMARK 465     ARG E   648                                                      
REMARK 465     LYS E   649                                                      
REMARK 465     ARG E   650                                                      
REMARK 465     PRO E   651                                                      
REMARK 465     ALA E   652                                                      
REMARK 465     ARG E   653                                                      
REMARK 465     GLU E   654                                                      
REMARK 465     ASP E   655                                                      
REMARK 465     CYS E   656                                                      
REMARK 465     ARG E   657                                                      
REMARK 465     GLY E   658                                                      
REMARK 465     LEU E   659                                                      
REMARK 465     THR E   660                                                      
REMARK 465     GLY E   661                                                      
REMARK 465     PRO E   662                                                      
REMARK 465     LEU E   663                                                      
REMARK 465     GLN E   664                                                      
REMARK 465     SER E   665                                                      
REMARK 465     LEU E   666                                                      
REMARK 465     VAL E   667                                                      
REMARK 465     PRO E   668                                                      
REMARK 465     SER E   669                                                      
REMARK 465     ALA E   670                                                      
REMARK 465     ASP E   671                                                      
REMARK 465     GLY E   672                                                      
REMARK 465     ASP E   673                                                      
REMARK 465     ALA E   674                                                      
REMARK 465     ASP E   675                                                      
REMARK 465     ASN E   676                                                      
REMARK 465     SER E   741                                                      
REMARK 465     LEU E   742                                                      
REMARK 465     PRO E   743                                                      
REMARK 465     ASP E   744                                                      
REMARK 465     SER E   745                                                      
REMARK 465     GLU E   746                                                      
REMARK 465     ILE E   747                                                      
REMARK 465     GLY E   748                                                      
REMARK 465     GLU E   749                                                      
REMARK 465     ASP E   750                                                      
REMARK 465     PRO E   751                                                      
REMARK 465     SER E   752                                                      
REMARK 465     PRO E   753                                                      
REMARK 465     GLU E   754                                                      
REMARK 465     ARG E   755                                                      
REMARK 465     GLU E   756                                                      
REMARK 465     THR E   757                                                      
REMARK 465     ALA E   758                                                      
REMARK 465     THR E   759                                                      
REMARK 465     ASP E   760                                                      
REMARK 465     LEU E   761                                                      
REMARK 465     ASP E   762                                                      
REMARK 465     ILE E   763                                                      
REMARK 465     ARG E   764                                                      
REMARK 465     LYS E   765                                                      
REMARK 465     MET E   931                                                      
REMARK 465     ASN E   932                                                      
REMARK 465     ARG E   933                                                      
REMARK 465     GLN E   934                                                      
REMARK 465     ASP E   935                                                      
REMARK 465     GLN E   936                                                      
REMARK 465     GLU E   937                                                      
REMARK 465     LEU E   938                                                      
REMARK 465     GLU E   939                                                      
REMARK 465     LYS E   940                                                      
REMARK 465     GLU E   941                                                      
REMARK 465     THR E   942                                                      
REMARK 465     VAL E   943                                                      
REMARK 465     THR E   944                                                      
REMARK 465     GLU E   945                                                      
REMARK 465     ARG E   946                                                      
REMARK 465     LYS E   947                                                      
REMARK 465     ALA E   948                                                      
REMARK 465     THR E   949                                                      
REMARK 465     GLU E   950                                                      
REMARK 465     PRO E   951                                                      
REMARK 465     PRO E   952                                                      
REMARK 465     GLN E   953                                                      
REMARK 465     GLY E   954                                                      
REMARK 465     LEU E   955                                                      
REMARK 465     SER E   956                                                      
REMARK 465     ARG E   957                                                      
REMARK 465     ALA E   958                                                      
REMARK 465     MET E   959                                                      
REMARK 465     SER E   960                                                      
REMARK 465     SER E   961                                                      
REMARK 465     ARG E   962                                                      
REMARK 465     ASP E   963                                                      
REMARK 465     GLY E   964                                                      
REMARK 465     LEU E   965                                                      
REMARK 465     LEU E   966                                                      
REMARK 465     GLN E   967                                                      
REMARK 465     ASP E   968                                                      
REMARK 465     GLU E   969                                                      
REMARK 465     GLU E   970                                                      
REMARK 465     GLU E   971                                                      
REMARK 465     GLU E   972                                                      
REMARK 465     GLU E   973                                                      
REMARK 465     GLU E   974                                                      
REMARK 465     GLU E   975                                                      
REMARK 465     ALA E   976                                                      
REMARK 465     ALA E   977                                                      
REMARK 465     GLU E   978                                                      
REMARK 465     SER E   979                                                      
REMARK 465     GLU E   980                                                      
REMARK 465     GLU E   981                                                      
REMARK 465     ASP E   982                                                      
REMARK 465     ASP E   983                                                      
REMARK 465     ASN E   984                                                      
REMARK 465     LEU E   985                                                      
REMARK 465     SER E   986                                                      
REMARK 465     SER E   987                                                      
REMARK 465     MET E   988                                                      
REMARK 465     LEU E   989                                                      
REMARK 465     HIS E   990                                                      
REMARK 465     GLN E   991                                                      
REMARK 465     ARG E   992                                                      
REMARK 465     ALA E   993                                                      
REMARK 465     SER E  1039                                                      
REMARK 465     ALA E  1040                                                      
REMARK 465     LEU E  1041                                                      
REMARK 465     THR E  1042                                                      
REMARK 465     LEU E  1043                                                      
REMARK 465     THR E  1044                                                      
REMARK 465     PRO E  1045                                                      
REMARK 465     ALA E  1046                                                      
REMARK 465     ALA E  1047                                                      
REMARK 465     ARG E  1048                                                      
REMARK 465     ASN E  1049                                                      
REMARK 465     CYS E  1050                                                      
REMARK 465     SER E  1051                                                      
REMARK 465     LEU E  1052                                                      
REMARK 465     SER E  1053                                                      
REMARK 465     GLN E  1054                                                      
REMARK 465     GLU E  1055                                                      
REMARK 465     CYS E  1056                                                      
REMARK 465     THR E  1057                                                      
REMARK 465     LEU E  1058                                                      
REMARK 465     ASP E  1059                                                      
REMARK 465     GLN E  1060                                                      
REMARK 465     MET H     1                                                      
REMARK 465     SER H    53                                                      
REMARK 465     GLN H    54                                                      
REMARK 465     SER H    55                                                      
REMARK 465     SER H    56                                                      
REMARK 465     LYS H    57                                                      
REMARK 465     VAL H    58                                                      
REMARK 465     HIS H    59                                                      
REMARK 465     ILE H    60                                                      
REMARK 465     HIS H    61                                                      
REMARK 465     HIS H    62                                                      
REMARK 465     SER H    63                                                      
REMARK 465     THR H    64                                                      
REMARK 465     TRP H    65                                                      
REMARK 465     LEU H    66                                                      
REMARK 465     HIS H    67                                                      
REMARK 465     ARG H   193                                                      
REMARK 465     ARG H   194                                                      
REMARK 465     TYR H   195                                                      
REMARK 465     ILE H   196                                                      
REMARK 465     PHE H   197                                                      
REMARK 465     PHE H   198                                                      
REMARK 465     LYS H   199                                                      
REMARK 465     THR H   200                                                      
REMARK 465     PRO H   201                                                      
REMARK 465     ARG H   202                                                      
REMARK 465     GLU H   203                                                      
REMARK 465     VAL H   204                                                      
REMARK 465     LYS H   205                                                      
REMARK 465     PRO H   206                                                      
REMARK 465     PRO H   207                                                      
REMARK 465     GLU H   208                                                      
REMARK 465     ASP H   209                                                      
REMARK 465     LEU H   210                                                      
REMARK 465     GLN H   211                                                      
REMARK 465     ASP H   212                                                      
REMARK 465     LEU H   213                                                      
REMARK 465     GLY H   214                                                      
REMARK 465     VAL H   215                                                      
REMARK 465     ARG H   216                                                      
REMARK 465     PHE H   217                                                      
REMARK 465     LEU H   218                                                      
REMARK 465     GLN H   219                                                      
REMARK 465     PRO H   220                                                      
REMARK 465     PHE H   221                                                      
REMARK 465     VAL H   222                                                      
REMARK 465     ASN H   223                                                      
REMARK 465     LEU H   224                                                      
REMARK 465     LEU H   225                                                      
REMARK 465     SER H   226                                                      
REMARK 465     LYS H   227                                                      
REMARK 465     GLY H   228                                                      
REMARK 465     THR H   229                                                      
REMARK 465     TYR H   230                                                      
REMARK 465     TRP H   231                                                      
REMARK 465     TRP H   232                                                      
REMARK 465     MET H   233                                                      
REMARK 465     ASN H   234                                                      
REMARK 465     ALA H   235                                                      
REMARK 465     PHE H   236                                                      
REMARK 465     ILE H   237                                                      
REMARK 465     LYS H   238                                                      
REMARK 465     THR H   239                                                      
REMARK 465     ALA H   240                                                      
REMARK 465     HIS H   241                                                      
REMARK 465     LYS H   242                                                      
REMARK 465     LYS H   243                                                      
REMARK 465     PRO H   244                                                      
REMARK 465     ILE H   245                                                      
REMARK 465     ASP H   246                                                      
REMARK 465     LEU H   247                                                      
REMARK 465     ARG H   248                                                      
REMARK 465     ALA H   249                                                      
REMARK 465     ILE H   250                                                      
REMARK 465     GLY H   251                                                      
REMARK 465     LYS H   252                                                      
REMARK 465     LEU H   253                                                      
REMARK 465     PRO H   254                                                      
REMARK 465     ILE H   255                                                      
REMARK 465     ALA H   256                                                      
REMARK 465     MET H   257                                                      
REMARK 465     ARG H   258                                                      
REMARK 465     ALA H   259                                                      
REMARK 465     LEU H   260                                                      
REMARK 465     THR H   261                                                      
REMARK 465     ILE H   278                                                      
REMARK 465     GLN H   279                                                      
REMARK 465     GLY H   280                                                      
REMARK 465     THR H   281                                                      
REMARK 465     GLN H   282                                                      
REMARK 465     GLY H   283                                                      
REMARK 465     ALA H   284                                                      
REMARK 465     ARG H   285                                                      
REMARK 465     GLU H   330                                                      
REMARK 465     ASN H   331                                                      
REMARK 465     ASP H   332                                                      
REMARK 465     VAL H   333                                                      
REMARK 465     PHE H   334                                                      
REMARK 465     GLN H   335                                                      
REMARK 465     PRO H   336                                                      
REMARK 465     LYS H   337                                                      
REMARK 465     THR H   338                                                      
REMARK 465     GLN H   339                                                      
REMARK 465     PHE H   340                                                      
REMARK 465     LEU H   341                                                      
REMARK 465     GLY H   342                                                      
REMARK 465     VAL H   343                                                      
REMARK 465     TYR H   344                                                      
REMARK 465     PHE H   345                                                      
REMARK 465     VAL H   346                                                      
REMARK 465     SER H   347                                                      
REMARK 465     SER H   348                                                      
REMARK 465     GLN H   349                                                      
REMARK 465     GLU H   350                                                      
REMARK 465     PHE H   351                                                      
REMARK 465     LEU H   352                                                      
REMARK 465     SER H   564                                                      
REMARK 465     PHE H   565                                                      
REMARK 465     PHE H   566                                                      
REMARK 465     LYS H   567                                                      
REMARK 465     GLU H   568                                                      
REMARK 465     ALA H   569                                                      
REMARK 465     ASP H   570                                                      
REMARK 465     PHE H   571                                                      
REMARK 465     SER H   572                                                      
REMARK 465     GLU H   621                                                      
REMARK 465     GLU H   622                                                      
REMARK 465     GLN H   623                                                      
REMARK 465     CYS H   624                                                      
REMARK 465     ALA H   625                                                      
REMARK 465     PRO H   626                                                      
REMARK 465     HIS H   627                                                      
REMARK 465     GLU H   628                                                      
REMARK 465     PRO H   629                                                      
REMARK 465     THR H   630                                                      
REMARK 465     PRO H   631                                                      
REMARK 465     GLN H   632                                                      
REMARK 465     GLY H   633                                                      
REMARK 465     PRO H   634                                                      
REMARK 465     ALA H   635                                                      
REMARK 465     SER H   636                                                      
REMARK 465     LYS H   637                                                      
REMARK 465     TYR H   638                                                      
REMARK 465     GLN H   639                                                      
REMARK 465     ALA H   640                                                      
REMARK 465     VAL H   641                                                      
REMARK 465     PRO H   642                                                      
REMARK 465     LEU H   643                                                      
REMARK 465     ARG H   644                                                      
REMARK 465     VAL H   645                                                      
REMARK 465     VAL H   646                                                      
REMARK 465     ASN H   647                                                      
REMARK 465     ARG H   648                                                      
REMARK 465     LYS H   649                                                      
REMARK 465     ARG H   650                                                      
REMARK 465     PRO H   651                                                      
REMARK 465     ALA H   652                                                      
REMARK 465     ARG H   653                                                      
REMARK 465     GLU H   654                                                      
REMARK 465     ASP H   655                                                      
REMARK 465     CYS H   656                                                      
REMARK 465     ARG H   657                                                      
REMARK 465     GLY H   658                                                      
REMARK 465     LEU H   659                                                      
REMARK 465     THR H   660                                                      
REMARK 465     GLY H   661                                                      
REMARK 465     PRO H   662                                                      
REMARK 465     LEU H   663                                                      
REMARK 465     GLN H   664                                                      
REMARK 465     SER H   665                                                      
REMARK 465     LEU H   666                                                      
REMARK 465     VAL H   667                                                      
REMARK 465     PRO H   668                                                      
REMARK 465     SER H   669                                                      
REMARK 465     ALA H   670                                                      
REMARK 465     ASP H   671                                                      
REMARK 465     GLY H   672                                                      
REMARK 465     ASP H   673                                                      
REMARK 465     ALA H   674                                                      
REMARK 465     ASP H   675                                                      
REMARK 465     ASN H   676                                                      
REMARK 465     SER H   741                                                      
REMARK 465     LEU H   742                                                      
REMARK 465     PRO H   743                                                      
REMARK 465     ASP H   744                                                      
REMARK 465     SER H   745                                                      
REMARK 465     GLU H   746                                                      
REMARK 465     ILE H   747                                                      
REMARK 465     GLY H   748                                                      
REMARK 465     GLU H   749                                                      
REMARK 465     ASP H   750                                                      
REMARK 465     PRO H   751                                                      
REMARK 465     SER H   752                                                      
REMARK 465     PRO H   753                                                      
REMARK 465     GLU H   754                                                      
REMARK 465     ARG H   755                                                      
REMARK 465     GLU H   756                                                      
REMARK 465     THR H   757                                                      
REMARK 465     ALA H   758                                                      
REMARK 465     THR H   759                                                      
REMARK 465     ASP H   760                                                      
REMARK 465     LEU H   761                                                      
REMARK 465     ASP H   762                                                      
REMARK 465     ILE H   763                                                      
REMARK 465     ARG H   764                                                      
REMARK 465     LYS H   765                                                      
REMARK 465     MET H   931                                                      
REMARK 465     ASN H   932                                                      
REMARK 465     ARG H   933                                                      
REMARK 465     GLN H   934                                                      
REMARK 465     ASP H   935                                                      
REMARK 465     GLN H   936                                                      
REMARK 465     GLU H   937                                                      
REMARK 465     LEU H   938                                                      
REMARK 465     GLU H   939                                                      
REMARK 465     LYS H   940                                                      
REMARK 465     GLU H   941                                                      
REMARK 465     THR H   942                                                      
REMARK 465     VAL H   943                                                      
REMARK 465     THR H   944                                                      
REMARK 465     GLU H   945                                                      
REMARK 465     ARG H   946                                                      
REMARK 465     LYS H   947                                                      
REMARK 465     ALA H   948                                                      
REMARK 465     THR H   949                                                      
REMARK 465     GLU H   950                                                      
REMARK 465     PRO H   951                                                      
REMARK 465     PRO H   952                                                      
REMARK 465     GLN H   953                                                      
REMARK 465     GLY H   954                                                      
REMARK 465     LEU H   955                                                      
REMARK 465     SER H   956                                                      
REMARK 465     ARG H   957                                                      
REMARK 465     ALA H   958                                                      
REMARK 465     MET H   959                                                      
REMARK 465     SER H   960                                                      
REMARK 465     SER H   961                                                      
REMARK 465     ARG H   962                                                      
REMARK 465     ASP H   963                                                      
REMARK 465     GLY H   964                                                      
REMARK 465     LEU H   965                                                      
REMARK 465     LEU H   966                                                      
REMARK 465     GLN H   967                                                      
REMARK 465     ASP H   968                                                      
REMARK 465     GLU H   969                                                      
REMARK 465     GLU H   970                                                      
REMARK 465     GLU H   971                                                      
REMARK 465     GLU H   972                                                      
REMARK 465     GLU H   973                                                      
REMARK 465     GLU H   974                                                      
REMARK 465     GLU H   975                                                      
REMARK 465     ALA H   976                                                      
REMARK 465     ALA H   977                                                      
REMARK 465     GLU H   978                                                      
REMARK 465     SER H   979                                                      
REMARK 465     GLU H   980                                                      
REMARK 465     GLU H   981                                                      
REMARK 465     ASP H   982                                                      
REMARK 465     ASP H   983                                                      
REMARK 465     ASN H   984                                                      
REMARK 465     LEU H   985                                                      
REMARK 465     SER H   986                                                      
REMARK 465     SER H   987                                                      
REMARK 465     MET H   988                                                      
REMARK 465     LEU H   989                                                      
REMARK 465     HIS H   990                                                      
REMARK 465     GLN H   991                                                      
REMARK 465     ARG H   992                                                      
REMARK 465     ALA H   993                                                      
REMARK 465     SER H  1039                                                      
REMARK 465     ALA H  1040                                                      
REMARK 465     LEU H  1041                                                      
REMARK 465     THR H  1042                                                      
REMARK 465     LEU H  1043                                                      
REMARK 465     THR H  1044                                                      
REMARK 465     PRO H  1045                                                      
REMARK 465     ALA H  1046                                                      
REMARK 465     ALA H  1047                                                      
REMARK 465     ARG H  1048                                                      
REMARK 465     ASN H  1049                                                      
REMARK 465     CYS H  1050                                                      
REMARK 465     SER H  1051                                                      
REMARK 465     LEU H  1052                                                      
REMARK 465     SER H  1053                                                      
REMARK 465     GLN H  1054                                                      
REMARK 465     GLU H  1055                                                      
REMARK 465     CYS H  1056                                                      
REMARK 465     THR H  1057                                                      
REMARK 465     LEU H  1058                                                      
REMARK 465     ASP H  1059                                                      
REMARK 465     GLN H  1060                                                      
REMARK 465     MET G     1                                                      
REMARK 465     SER G    53                                                      
REMARK 465     GLN G    54                                                      
REMARK 465     SER G    55                                                      
REMARK 465     SER G    56                                                      
REMARK 465     LYS G    57                                                      
REMARK 465     VAL G    58                                                      
REMARK 465     HIS G    59                                                      
REMARK 465     ILE G    60                                                      
REMARK 465     HIS G    61                                                      
REMARK 465     HIS G    62                                                      
REMARK 465     SER G    63                                                      
REMARK 465     THR G    64                                                      
REMARK 465     TRP G    65                                                      
REMARK 465     LEU G    66                                                      
REMARK 465     HIS G    67                                                      
REMARK 465     ARG G   193                                                      
REMARK 465     ARG G   194                                                      
REMARK 465     TYR G   195                                                      
REMARK 465     ILE G   196                                                      
REMARK 465     PHE G   197                                                      
REMARK 465     PHE G   198                                                      
REMARK 465     LYS G   199                                                      
REMARK 465     THR G   200                                                      
REMARK 465     PRO G   201                                                      
REMARK 465     ARG G   202                                                      
REMARK 465     GLU G   203                                                      
REMARK 465     VAL G   204                                                      
REMARK 465     LYS G   205                                                      
REMARK 465     PRO G   206                                                      
REMARK 465     PRO G   207                                                      
REMARK 465     GLU G   208                                                      
REMARK 465     ASP G   209                                                      
REMARK 465     LEU G   210                                                      
REMARK 465     GLN G   211                                                      
REMARK 465     ASP G   212                                                      
REMARK 465     LEU G   213                                                      
REMARK 465     GLY G   214                                                      
REMARK 465     VAL G   215                                                      
REMARK 465     ARG G   216                                                      
REMARK 465     PHE G   217                                                      
REMARK 465     LEU G   218                                                      
REMARK 465     GLN G   219                                                      
REMARK 465     PRO G   220                                                      
REMARK 465     PHE G   221                                                      
REMARK 465     VAL G   222                                                      
REMARK 465     ASN G   223                                                      
REMARK 465     LEU G   224                                                      
REMARK 465     LEU G   225                                                      
REMARK 465     SER G   226                                                      
REMARK 465     LYS G   227                                                      
REMARK 465     GLY G   228                                                      
REMARK 465     THR G   229                                                      
REMARK 465     TYR G   230                                                      
REMARK 465     TRP G   231                                                      
REMARK 465     TRP G   232                                                      
REMARK 465     MET G   233                                                      
REMARK 465     ASN G   234                                                      
REMARK 465     ALA G   235                                                      
REMARK 465     PHE G   236                                                      
REMARK 465     ILE G   237                                                      
REMARK 465     LYS G   238                                                      
REMARK 465     THR G   239                                                      
REMARK 465     ALA G   240                                                      
REMARK 465     HIS G   241                                                      
REMARK 465     LYS G   242                                                      
REMARK 465     LYS G   243                                                      
REMARK 465     PRO G   244                                                      
REMARK 465     ILE G   245                                                      
REMARK 465     ASP G   246                                                      
REMARK 465     LEU G   247                                                      
REMARK 465     ARG G   248                                                      
REMARK 465     ALA G   249                                                      
REMARK 465     ILE G   250                                                      
REMARK 465     GLY G   251                                                      
REMARK 465     LYS G   252                                                      
REMARK 465     LEU G   253                                                      
REMARK 465     PRO G   254                                                      
REMARK 465     ILE G   255                                                      
REMARK 465     ALA G   256                                                      
REMARK 465     MET G   257                                                      
REMARK 465     ARG G   258                                                      
REMARK 465     ALA G   259                                                      
REMARK 465     LEU G   260                                                      
REMARK 465     THR G   261                                                      
REMARK 465     ILE G   278                                                      
REMARK 465     GLN G   279                                                      
REMARK 465     GLY G   280                                                      
REMARK 465     THR G   281                                                      
REMARK 465     GLN G   282                                                      
REMARK 465     GLY G   283                                                      
REMARK 465     ALA G   284                                                      
REMARK 465     ARG G   285                                                      
REMARK 465     GLU G   330                                                      
REMARK 465     ASN G   331                                                      
REMARK 465     ASP G   332                                                      
REMARK 465     VAL G   333                                                      
REMARK 465     PHE G   334                                                      
REMARK 465     GLN G   335                                                      
REMARK 465     PRO G   336                                                      
REMARK 465     LYS G   337                                                      
REMARK 465     THR G   338                                                      
REMARK 465     GLN G   339                                                      
REMARK 465     PHE G   340                                                      
REMARK 465     LEU G   341                                                      
REMARK 465     GLY G   342                                                      
REMARK 465     VAL G   343                                                      
REMARK 465     TYR G   344                                                      
REMARK 465     PHE G   345                                                      
REMARK 465     VAL G   346                                                      
REMARK 465     SER G   347                                                      
REMARK 465     SER G   348                                                      
REMARK 465     GLN G   349                                                      
REMARK 465     GLU G   350                                                      
REMARK 465     PHE G   351                                                      
REMARK 465     LEU G   352                                                      
REMARK 465     SER G   564                                                      
REMARK 465     PHE G   565                                                      
REMARK 465     PHE G   566                                                      
REMARK 465     LYS G   567                                                      
REMARK 465     GLU G   568                                                      
REMARK 465     ALA G   569                                                      
REMARK 465     ASP G   570                                                      
REMARK 465     PHE G   571                                                      
REMARK 465     SER G   572                                                      
REMARK 465     GLU G   621                                                      
REMARK 465     GLU G   622                                                      
REMARK 465     GLN G   623                                                      
REMARK 465     CYS G   624                                                      
REMARK 465     ALA G   625                                                      
REMARK 465     PRO G   626                                                      
REMARK 465     HIS G   627                                                      
REMARK 465     GLU G   628                                                      
REMARK 465     PRO G   629                                                      
REMARK 465     THR G   630                                                      
REMARK 465     PRO G   631                                                      
REMARK 465     GLN G   632                                                      
REMARK 465     GLY G   633                                                      
REMARK 465     PRO G   634                                                      
REMARK 465     ALA G   635                                                      
REMARK 465     SER G   636                                                      
REMARK 465     LYS G   637                                                      
REMARK 465     TYR G   638                                                      
REMARK 465     GLN G   639                                                      
REMARK 465     ALA G   640                                                      
REMARK 465     VAL G   641                                                      
REMARK 465     PRO G   642                                                      
REMARK 465     LEU G   643                                                      
REMARK 465     ARG G   644                                                      
REMARK 465     VAL G   645                                                      
REMARK 465     VAL G   646                                                      
REMARK 465     ASN G   647                                                      
REMARK 465     ARG G   648                                                      
REMARK 465     LYS G   649                                                      
REMARK 465     ARG G   650                                                      
REMARK 465     PRO G   651                                                      
REMARK 465     ALA G   652                                                      
REMARK 465     ARG G   653                                                      
REMARK 465     GLU G   654                                                      
REMARK 465     ASP G   655                                                      
REMARK 465     CYS G   656                                                      
REMARK 465     ARG G   657                                                      
REMARK 465     GLY G   658                                                      
REMARK 465     LEU G   659                                                      
REMARK 465     THR G   660                                                      
REMARK 465     GLY G   661                                                      
REMARK 465     PRO G   662                                                      
REMARK 465     LEU G   663                                                      
REMARK 465     GLN G   664                                                      
REMARK 465     SER G   665                                                      
REMARK 465     LEU G   666                                                      
REMARK 465     VAL G   667                                                      
REMARK 465     PRO G   668                                                      
REMARK 465     SER G   669                                                      
REMARK 465     ALA G   670                                                      
REMARK 465     ASP G   671                                                      
REMARK 465     GLY G   672                                                      
REMARK 465     ASP G   673                                                      
REMARK 465     ALA G   674                                                      
REMARK 465     ASP G   675                                                      
REMARK 465     ASN G   676                                                      
REMARK 465     SER G   741                                                      
REMARK 465     LEU G   742                                                      
REMARK 465     PRO G   743                                                      
REMARK 465     ASP G   744                                                      
REMARK 465     SER G   745                                                      
REMARK 465     GLU G   746                                                      
REMARK 465     ILE G   747                                                      
REMARK 465     GLY G   748                                                      
REMARK 465     GLU G   749                                                      
REMARK 465     ASP G   750                                                      
REMARK 465     PRO G   751                                                      
REMARK 465     SER G   752                                                      
REMARK 465     PRO G   753                                                      
REMARK 465     GLU G   754                                                      
REMARK 465     ARG G   755                                                      
REMARK 465     GLU G   756                                                      
REMARK 465     THR G   757                                                      
REMARK 465     ALA G   758                                                      
REMARK 465     THR G   759                                                      
REMARK 465     ASP G   760                                                      
REMARK 465     LEU G   761                                                      
REMARK 465     ASP G   762                                                      
REMARK 465     ILE G   763                                                      
REMARK 465     ARG G   764                                                      
REMARK 465     LYS G   765                                                      
REMARK 465     MET G   931                                                      
REMARK 465     ASN G   932                                                      
REMARK 465     ARG G   933                                                      
REMARK 465     GLN G   934                                                      
REMARK 465     ASP G   935                                                      
REMARK 465     GLN G   936                                                      
REMARK 465     GLU G   937                                                      
REMARK 465     LEU G   938                                                      
REMARK 465     GLU G   939                                                      
REMARK 465     LYS G   940                                                      
REMARK 465     GLU G   941                                                      
REMARK 465     THR G   942                                                      
REMARK 465     VAL G   943                                                      
REMARK 465     THR G   944                                                      
REMARK 465     GLU G   945                                                      
REMARK 465     ARG G   946                                                      
REMARK 465     LYS G   947                                                      
REMARK 465     ALA G   948                                                      
REMARK 465     THR G   949                                                      
REMARK 465     GLU G   950                                                      
REMARK 465     PRO G   951                                                      
REMARK 465     PRO G   952                                                      
REMARK 465     GLN G   953                                                      
REMARK 465     GLY G   954                                                      
REMARK 465     LEU G   955                                                      
REMARK 465     SER G   956                                                      
REMARK 465     ARG G   957                                                      
REMARK 465     ALA G   958                                                      
REMARK 465     MET G   959                                                      
REMARK 465     SER G   960                                                      
REMARK 465     SER G   961                                                      
REMARK 465     ARG G   962                                                      
REMARK 465     ASP G   963                                                      
REMARK 465     GLY G   964                                                      
REMARK 465     LEU G   965                                                      
REMARK 465     LEU G   966                                                      
REMARK 465     GLN G   967                                                      
REMARK 465     ASP G   968                                                      
REMARK 465     GLU G   969                                                      
REMARK 465     GLU G   970                                                      
REMARK 465     GLU G   971                                                      
REMARK 465     GLU G   972                                                      
REMARK 465     GLU G   973                                                      
REMARK 465     GLU G   974                                                      
REMARK 465     GLU G   975                                                      
REMARK 465     ALA G   976                                                      
REMARK 465     ALA G   977                                                      
REMARK 465     GLU G   978                                                      
REMARK 465     SER G   979                                                      
REMARK 465     GLU G   980                                                      
REMARK 465     GLU G   981                                                      
REMARK 465     ASP G   982                                                      
REMARK 465     ASP G   983                                                      
REMARK 465     ASN G   984                                                      
REMARK 465     LEU G   985                                                      
REMARK 465     SER G   986                                                      
REMARK 465     SER G   987                                                      
REMARK 465     MET G   988                                                      
REMARK 465     LEU G   989                                                      
REMARK 465     HIS G   990                                                      
REMARK 465     GLN G   991                                                      
REMARK 465     ARG G   992                                                      
REMARK 465     ALA G   993                                                      
REMARK 465     SER G  1039                                                      
REMARK 465     ALA G  1040                                                      
REMARK 465     LEU G  1041                                                      
REMARK 465     THR G  1042                                                      
REMARK 465     LEU G  1043                                                      
REMARK 465     THR G  1044                                                      
REMARK 465     PRO G  1045                                                      
REMARK 465     ALA G  1046                                                      
REMARK 465     ALA G  1047                                                      
REMARK 465     ARG G  1048                                                      
REMARK 465     ASN G  1049                                                      
REMARK 465     CYS G  1050                                                      
REMARK 465     SER G  1051                                                      
REMARK 465     LEU G  1052                                                      
REMARK 465     SER G  1053                                                      
REMARK 465     GLN G  1054                                                      
REMARK 465     GLU G  1055                                                      
REMARK 465     CYS G  1056                                                      
REMARK 465     THR G  1057                                                      
REMARK 465     LEU G  1058                                                      
REMARK 465     ASP G  1059                                                      
REMARK 465     GLN G  1060                                                      
REMARK 465     MET F     1                                                      
REMARK 465     SER F    53                                                      
REMARK 465     GLN F    54                                                      
REMARK 465     SER F    55                                                      
REMARK 465     SER F    56                                                      
REMARK 465     LYS F    57                                                      
REMARK 465     VAL F    58                                                      
REMARK 465     HIS F    59                                                      
REMARK 465     ILE F    60                                                      
REMARK 465     HIS F    61                                                      
REMARK 465     HIS F    62                                                      
REMARK 465     SER F    63                                                      
REMARK 465     THR F    64                                                      
REMARK 465     TRP F    65                                                      
REMARK 465     LEU F    66                                                      
REMARK 465     HIS F    67                                                      
REMARK 465     ARG F   193                                                      
REMARK 465     ARG F   194                                                      
REMARK 465     TYR F   195                                                      
REMARK 465     ILE F   196                                                      
REMARK 465     PHE F   197                                                      
REMARK 465     PHE F   198                                                      
REMARK 465     LYS F   199                                                      
REMARK 465     THR F   200                                                      
REMARK 465     PRO F   201                                                      
REMARK 465     ARG F   202                                                      
REMARK 465     GLU F   203                                                      
REMARK 465     VAL F   204                                                      
REMARK 465     LYS F   205                                                      
REMARK 465     PRO F   206                                                      
REMARK 465     PRO F   207                                                      
REMARK 465     GLU F   208                                                      
REMARK 465     ASP F   209                                                      
REMARK 465     LEU F   210                                                      
REMARK 465     GLN F   211                                                      
REMARK 465     ASP F   212                                                      
REMARK 465     LEU F   213                                                      
REMARK 465     GLY F   214                                                      
REMARK 465     VAL F   215                                                      
REMARK 465     ARG F   216                                                      
REMARK 465     PHE F   217                                                      
REMARK 465     LEU F   218                                                      
REMARK 465     GLN F   219                                                      
REMARK 465     PRO F   220                                                      
REMARK 465     PHE F   221                                                      
REMARK 465     VAL F   222                                                      
REMARK 465     ASN F   223                                                      
REMARK 465     LEU F   224                                                      
REMARK 465     LEU F   225                                                      
REMARK 465     SER F   226                                                      
REMARK 465     LYS F   227                                                      
REMARK 465     GLY F   228                                                      
REMARK 465     THR F   229                                                      
REMARK 465     TYR F   230                                                      
REMARK 465     TRP F   231                                                      
REMARK 465     TRP F   232                                                      
REMARK 465     MET F   233                                                      
REMARK 465     ASN F   234                                                      
REMARK 465     ALA F   235                                                      
REMARK 465     PHE F   236                                                      
REMARK 465     ILE F   237                                                      
REMARK 465     LYS F   238                                                      
REMARK 465     THR F   239                                                      
REMARK 465     ALA F   240                                                      
REMARK 465     HIS F   241                                                      
REMARK 465     LYS F   242                                                      
REMARK 465     LYS F   243                                                      
REMARK 465     PRO F   244                                                      
REMARK 465     ILE F   245                                                      
REMARK 465     ASP F   246                                                      
REMARK 465     LEU F   247                                                      
REMARK 465     ARG F   248                                                      
REMARK 465     ALA F   249                                                      
REMARK 465     ILE F   250                                                      
REMARK 465     GLY F   251                                                      
REMARK 465     LYS F   252                                                      
REMARK 465     LEU F   253                                                      
REMARK 465     PRO F   254                                                      
REMARK 465     ILE F   255                                                      
REMARK 465     ALA F   256                                                      
REMARK 465     MET F   257                                                      
REMARK 465     ARG F   258                                                      
REMARK 465     ALA F   259                                                      
REMARK 465     LEU F   260                                                      
REMARK 465     THR F   261                                                      
REMARK 465     ILE F   278                                                      
REMARK 465     GLN F   279                                                      
REMARK 465     GLY F   280                                                      
REMARK 465     THR F   281                                                      
REMARK 465     GLN F   282                                                      
REMARK 465     GLY F   283                                                      
REMARK 465     ALA F   284                                                      
REMARK 465     ARG F   285                                                      
REMARK 465     GLU F   330                                                      
REMARK 465     ASN F   331                                                      
REMARK 465     ASP F   332                                                      
REMARK 465     VAL F   333                                                      
REMARK 465     PHE F   334                                                      
REMARK 465     GLN F   335                                                      
REMARK 465     PRO F   336                                                      
REMARK 465     LYS F   337                                                      
REMARK 465     THR F   338                                                      
REMARK 465     GLN F   339                                                      
REMARK 465     PHE F   340                                                      
REMARK 465     LEU F   341                                                      
REMARK 465     GLY F   342                                                      
REMARK 465     VAL F   343                                                      
REMARK 465     TYR F   344                                                      
REMARK 465     PHE F   345                                                      
REMARK 465     VAL F   346                                                      
REMARK 465     SER F   347                                                      
REMARK 465     SER F   348                                                      
REMARK 465     GLN F   349                                                      
REMARK 465     GLU F   350                                                      
REMARK 465     PHE F   351                                                      
REMARK 465     LEU F   352                                                      
REMARK 465     SER F   564                                                      
REMARK 465     PHE F   565                                                      
REMARK 465     PHE F   566                                                      
REMARK 465     LYS F   567                                                      
REMARK 465     GLU F   568                                                      
REMARK 465     ALA F   569                                                      
REMARK 465     ASP F   570                                                      
REMARK 465     PHE F   571                                                      
REMARK 465     SER F   572                                                      
REMARK 465     GLU F   621                                                      
REMARK 465     GLU F   622                                                      
REMARK 465     GLN F   623                                                      
REMARK 465     CYS F   624                                                      
REMARK 465     ALA F   625                                                      
REMARK 465     PRO F   626                                                      
REMARK 465     HIS F   627                                                      
REMARK 465     GLU F   628                                                      
REMARK 465     PRO F   629                                                      
REMARK 465     THR F   630                                                      
REMARK 465     PRO F   631                                                      
REMARK 465     GLN F   632                                                      
REMARK 465     GLY F   633                                                      
REMARK 465     PRO F   634                                                      
REMARK 465     ALA F   635                                                      
REMARK 465     SER F   636                                                      
REMARK 465     LYS F   637                                                      
REMARK 465     TYR F   638                                                      
REMARK 465     GLN F   639                                                      
REMARK 465     ALA F   640                                                      
REMARK 465     VAL F   641                                                      
REMARK 465     PRO F   642                                                      
REMARK 465     LEU F   643                                                      
REMARK 465     ARG F   644                                                      
REMARK 465     VAL F   645                                                      
REMARK 465     VAL F   646                                                      
REMARK 465     ASN F   647                                                      
REMARK 465     ARG F   648                                                      
REMARK 465     LYS F   649                                                      
REMARK 465     ARG F   650                                                      
REMARK 465     PRO F   651                                                      
REMARK 465     ALA F   652                                                      
REMARK 465     ARG F   653                                                      
REMARK 465     GLU F   654                                                      
REMARK 465     ASP F   655                                                      
REMARK 465     CYS F   656                                                      
REMARK 465     ARG F   657                                                      
REMARK 465     GLY F   658                                                      
REMARK 465     LEU F   659                                                      
REMARK 465     THR F   660                                                      
REMARK 465     GLY F   661                                                      
REMARK 465     PRO F   662                                                      
REMARK 465     LEU F   663                                                      
REMARK 465     GLN F   664                                                      
REMARK 465     SER F   665                                                      
REMARK 465     LEU F   666                                                      
REMARK 465     VAL F   667                                                      
REMARK 465     PRO F   668                                                      
REMARK 465     SER F   669                                                      
REMARK 465     ALA F   670                                                      
REMARK 465     ASP F   671                                                      
REMARK 465     GLY F   672                                                      
REMARK 465     ASP F   673                                                      
REMARK 465     ALA F   674                                                      
REMARK 465     ASP F   675                                                      
REMARK 465     ASN F   676                                                      
REMARK 465     SER F   741                                                      
REMARK 465     LEU F   742                                                      
REMARK 465     PRO F   743                                                      
REMARK 465     ASP F   744                                                      
REMARK 465     SER F   745                                                      
REMARK 465     GLU F   746                                                      
REMARK 465     ILE F   747                                                      
REMARK 465     GLY F   748                                                      
REMARK 465     GLU F   749                                                      
REMARK 465     ASP F   750                                                      
REMARK 465     PRO F   751                                                      
REMARK 465     SER F   752                                                      
REMARK 465     PRO F   753                                                      
REMARK 465     GLU F   754                                                      
REMARK 465     ARG F   755                                                      
REMARK 465     GLU F   756                                                      
REMARK 465     THR F   757                                                      
REMARK 465     ALA F   758                                                      
REMARK 465     THR F   759                                                      
REMARK 465     ASP F   760                                                      
REMARK 465     LEU F   761                                                      
REMARK 465     ASP F   762                                                      
REMARK 465     ILE F   763                                                      
REMARK 465     ARG F   764                                                      
REMARK 465     LYS F   765                                                      
REMARK 465     MET F   931                                                      
REMARK 465     ASN F   932                                                      
REMARK 465     ARG F   933                                                      
REMARK 465     GLN F   934                                                      
REMARK 465     ASP F   935                                                      
REMARK 465     GLN F   936                                                      
REMARK 465     GLU F   937                                                      
REMARK 465     LEU F   938                                                      
REMARK 465     GLU F   939                                                      
REMARK 465     LYS F   940                                                      
REMARK 465     GLU F   941                                                      
REMARK 465     THR F   942                                                      
REMARK 465     VAL F   943                                                      
REMARK 465     THR F   944                                                      
REMARK 465     GLU F   945                                                      
REMARK 465     ARG F   946                                                      
REMARK 465     LYS F   947                                                      
REMARK 465     ALA F   948                                                      
REMARK 465     THR F   949                                                      
REMARK 465     GLU F   950                                                      
REMARK 465     PRO F   951                                                      
REMARK 465     PRO F   952                                                      
REMARK 465     GLN F   953                                                      
REMARK 465     GLY F   954                                                      
REMARK 465     LEU F   955                                                      
REMARK 465     SER F   956                                                      
REMARK 465     ARG F   957                                                      
REMARK 465     ALA F   958                                                      
REMARK 465     MET F   959                                                      
REMARK 465     SER F   960                                                      
REMARK 465     SER F   961                                                      
REMARK 465     ARG F   962                                                      
REMARK 465     ASP F   963                                                      
REMARK 465     GLY F   964                                                      
REMARK 465     LEU F   965                                                      
REMARK 465     LEU F   966                                                      
REMARK 465     GLN F   967                                                      
REMARK 465     ASP F   968                                                      
REMARK 465     GLU F   969                                                      
REMARK 465     GLU F   970                                                      
REMARK 465     GLU F   971                                                      
REMARK 465     GLU F   972                                                      
REMARK 465     GLU F   973                                                      
REMARK 465     GLU F   974                                                      
REMARK 465     GLU F   975                                                      
REMARK 465     ALA F   976                                                      
REMARK 465     ALA F   977                                                      
REMARK 465     GLU F   978                                                      
REMARK 465     SER F   979                                                      
REMARK 465     GLU F   980                                                      
REMARK 465     GLU F   981                                                      
REMARK 465     ASP F   982                                                      
REMARK 465     ASP F   983                                                      
REMARK 465     ASN F   984                                                      
REMARK 465     LEU F   985                                                      
REMARK 465     SER F   986                                                      
REMARK 465     SER F   987                                                      
REMARK 465     MET F   988                                                      
REMARK 465     LEU F   989                                                      
REMARK 465     HIS F   990                                                      
REMARK 465     GLN F   991                                                      
REMARK 465     ARG F   992                                                      
REMARK 465     ALA F   993                                                      
REMARK 465     SER F  1039                                                      
REMARK 465     ALA F  1040                                                      
REMARK 465     LEU F  1041                                                      
REMARK 465     THR F  1042                                                      
REMARK 465     LEU F  1043                                                      
REMARK 465     THR F  1044                                                      
REMARK 465     PRO F  1045                                                      
REMARK 465     ALA F  1046                                                      
REMARK 465     ALA F  1047                                                      
REMARK 465     ARG F  1048                                                      
REMARK 465     ASN F  1049                                                      
REMARK 465     CYS F  1050                                                      
REMARK 465     SER F  1051                                                      
REMARK 465     LEU F  1052                                                      
REMARK 465     SER F  1053                                                      
REMARK 465     GLN F  1054                                                      
REMARK 465     GLU F  1055                                                      
REMARK 465     CYS F  1056                                                      
REMARK 465     THR F  1057                                                      
REMARK 465     LEU F  1058                                                      
REMARK 465     ASP F  1059                                                      
REMARK 465     GLN F  1060                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ARG A  50    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A  51    CG   CD   OE1  OE2                                  
REMARK 470     GLN A  52    CG   CD   OE1  NE2                                  
REMARK 470     ARG A  54    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 104    CG   CD   OE1  OE2                                  
REMARK 470     THR A 106    OG1  CG2                                            
REMARK 470     HIS A 175    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS A 207    CG   CD   CE   NZ                                   
REMARK 470     ASP A 262    CG   OD1  OD2                                       
REMARK 470     VAL A 316    CG1  CG2                                            
REMARK 470     GLU A 322    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 323    CG   OD1  OD2                                       
REMARK 470     ASP A 352    CG   OD1  OD2                                       
REMARK 470     HIS A 353    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER A 354    OG                                                  
REMARK 470     LEU A 355    CG   CD1  CD2                                       
REMARK 470     LEU A 356    CG   CD1  CD2                                       
REMARK 470     GLU A 357    CG   CD   OE1  OE2                                  
REMARK 470     LEU A 359    CG   CD1  CD2                                       
REMARK 470     ARG C  50    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C  51    CG   CD   OE1  OE2                                  
REMARK 470     GLN C  52    CG   CD   OE1  NE2                                  
REMARK 470     ARG C  54    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 104    CG   CD   OE1  OE2                                  
REMARK 470     THR C 106    OG1  CG2                                            
REMARK 470     HIS C 175    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS C 207    CG   CD   CE   NZ                                   
REMARK 470     ASP C 262    CG   OD1  OD2                                       
REMARK 470     VAL C 316    CG1  CG2                                            
REMARK 470     GLU C 322    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 323    CG   OD1  OD2                                       
REMARK 470     ASP C 352    CG   OD1  OD2                                       
REMARK 470     HIS C 353    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER C 354    OG                                                  
REMARK 470     LEU C 355    CG   CD1  CD2                                       
REMARK 470     LEU C 356    CG   CD1  CD2                                       
REMARK 470     GLU C 357    CG   CD   OE1  OE2                                  
REMARK 470     LEU C 359    CG   CD1  CD2                                       
REMARK 470     ARG B  50    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B  51    CG   CD   OE1  OE2                                  
REMARK 470     GLN B  52    CG   CD   OE1  NE2                                  
REMARK 470     ARG B  54    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B 104    CG   CD   OE1  OE2                                  
REMARK 470     THR B 106    OG1  CG2                                            
REMARK 470     HIS B 175    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS B 207    CG   CD   CE   NZ                                   
REMARK 470     ASP B 262    CG   OD1  OD2                                       
REMARK 470     VAL B 316    CG1  CG2                                            
REMARK 470     GLU B 322    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 323    CG   OD1  OD2                                       
REMARK 470     ASP B 352    CG   OD1  OD2                                       
REMARK 470     HIS B 353    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER B 354    OG                                                  
REMARK 470     LEU B 355    CG   CD1  CD2                                       
REMARK 470     LEU B 356    CG   CD1  CD2                                       
REMARK 470     GLU B 357    CG   CD   OE1  OE2                                  
REMARK 470     LEU B 359    CG   CD1  CD2                                       
REMARK 470     ARG D  50    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D  51    CG   CD   OE1  OE2                                  
REMARK 470     GLN D  52    CG   CD   OE1  NE2                                  
REMARK 470     ARG D  54    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D 104    CG   CD   OE1  OE2                                  
REMARK 470     THR D 106    OG1  CG2                                            
REMARK 470     HIS D 175    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS D 207    CG   CD   CE   NZ                                   
REMARK 470     ASP D 262    CG   OD1  OD2                                       
REMARK 470     VAL D 316    CG1  CG2                                            
REMARK 470     GLU D 322    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 323    CG   OD1  OD2                                       
REMARK 470     ASP D 352    CG   OD1  OD2                                       
REMARK 470     HIS D 353    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER D 354    OG                                                  
REMARK 470     LEU D 355    CG   CD1  CD2                                       
REMARK 470     LEU D 356    CG   CD1  CD2                                       
REMARK 470     GLU D 357    CG   CD   OE1  OE2                                  
REMARK 470     LEU D 359    CG   CD1  CD2                                       
REMARK 470     SER E   8    OG                                                  
REMARK 470     GLU E   9    CG   CD   OE1  OE2                                  
REMARK 470     ASN E  10    CG   OD1  ND2                                       
REMARK 470     HIS E  11    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER E  12    OG                                                  
REMARK 470     TYR E  15    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN E  19    CG   CD   OE1  NE2                                  
REMARK 470     ASN E  72    CG   OD1  ND2                                       
REMARK 470     LEU E  73    CG   CD1  CD2                                       
REMARK 470     ILE E  76    CG1  CG2  CD1                                       
REMARK 470     MET E  80    CG   SD   CE                                        
REMARK 470     VAL E  86    CG1  CG2                                            
REMARK 470     GLU E  91    CG   CD   OE1  OE2                                  
REMARK 470     VAL E  98    CG1  CG2                                            
REMARK 470     THR E  99    OG1  CG2                                            
REMARK 470     GLU E 100    CG   CD   OE1  OE2                                  
REMARK 470     MET E 115    CG   SD   CE                                        
REMARK 470     ASN E 131    CG   OD1  ND2                                       
REMARK 470     ASP E 159    CG   OD1  OD2                                       
REMARK 470     HIS E 160    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE E 162    CG1  CG2  CD1                                       
REMARK 470     PHE E 164    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN E 166    CG   CD   OE1  NE2                                  
REMARK 470     LEU E 167    CG   CD1  CD2                                       
REMARK 470     ILE E 190    CG1  CG2  CD1                                       
REMARK 470     ARG E 191    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL E 192    CG1  CG2                                            
REMARK 470     ASN E 262    CG   OD1  ND2                                       
REMARK 470     TYR E 263    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN E 264    CG   CD   OE1  NE2                                  
REMARK 470     ARG E 265    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU E 266    CG   CD1  CD2                                       
REMARK 470     CYS E 267    SG                                                  
REMARK 470     GLU E 268    CG   CD   OE1  OE2                                  
REMARK 470     PHE E 270    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP E 271    CG   OD1  OD2                                       
REMARK 470     GLN E 273    CG   CD   OE1  NE2                                  
REMARK 470     VAL E 274    CG1  CG2                                            
REMARK 470     ARG E 275    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E 276    CG   CD   CE   NZ                                   
REMARK 470     ASP E 277    CG   OD1  OD2                                       
REMARK 470     ARG E 486    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E 523    CG   CD   OE1  OE2                                  
REMARK 470     VAL E 587    CG1  CG2                                            
REMARK 470     THR E 588    OG1  CG2                                            
REMARK 470     PHE E 591    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG E 620    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP E 691    CG   OD1  OD2                                       
REMARK 470     ILE E 693    CG1  CG2  CD1                                       
REMARK 470     ARG E 705    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN E 731    CG   CD   OE1  NE2                                  
REMARK 470     SER E 740    OG                                                  
REMARK 470     ARG E 766    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E 784    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 785    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 790    CG   CD   OE1  OE2                                  
REMARK 470     SER E 791    OG                                                  
REMARK 470     GLN E 796    CG   CD   OE1  NE2                                  
REMARK 470     ARG E 797    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP E 812    CG   OD1  OD2                                       
REMARK 470     GLU E 824    CG   CD   OE1  OE2                                  
REMARK 470     ARG E 825    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN E 828    CG   OD1  ND2                                       
REMARK 470     ASP E 879    CG   OD1  OD2                                       
REMARK 470     LYS E 880    CG   CD   CE   NZ                                   
REMARK 470     LYS E 903    CG   CD   CE   NZ                                   
REMARK 470     ASP E 904    CG   OD1  OD2                                       
REMARK 470     ARG E 909    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E 910    CG   CD   OE1  OE2                                  
REMARK 470     THR E 912    OG1  CG2                                            
REMARK 470     LEU E 913    CG   CD1  CD2                                       
REMARK 470     LYS E 914    CG   CD   CE   NZ                                   
REMARK 470     PHE E 916    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN E 917    CG   CD   OE1  NE2                                  
REMARK 470     SER E 919    OG                                                  
REMARK 470     GLU E 920    CG   CD   OE1  OE2                                  
REMARK 470     PHE E 924    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TRP E 927    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP E 927    CZ3  CH2                                            
REMARK 470     LYS E 928    CG   CD   CE   NZ                                   
REMARK 470     THR E 929    OG1  CG2                                            
REMARK 470     LEU E 930    CG   CD1  CD2                                       
REMARK 470     GLU E 994    CG   CD   OE1  OE2                                  
REMARK 470     ILE E 995    CG1  CG2  CD1                                       
REMARK 470     TRP E 997    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP E 997    CZ3  CH2                                            
REMARK 470     ARG E 998    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E1002    CG   CD   CE   NZ                                   
REMARK 470     SER E1013    OG                                                  
REMARK 470     THR E1061    OG1  CG2                                            
REMARK 470     GLU E1086    CG   CD   OE1  OE2                                  
REMARK 470     ARG E1095    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E1103    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E1113    CG   CD   OE1  OE2                                  
REMARK 470     SER E1276    OG                                                  
REMARK 470     LYS E1319    CG   CD   CE   NZ                                   
REMARK 470     GLU E1321    CG   CD   OE1  OE2                                  
REMARK 470     GLU E1323    CG   CD   OE1  OE2                                  
REMARK 470     SER E1324    OG                                                  
REMARK 470     GLU E1326    CG   CD   OE1  OE2                                  
REMARK 470     LEU E1328    CG   CD1  CD2                                       
REMARK 470     LEU E1329    CG   CD1  CD2                                       
REMARK 470     SER E1332    OG                                                  
REMARK 470     LEU E1333    CG   CD1  CD2                                       
REMARK 470     LYS E1336    CG   CD   CE   NZ                                   
REMARK 470     ASP E1340    CG   OD1  OD2                                       
REMARK 470     GLN E1341    CG   CD   OE1  NE2                                  
REMARK 470     GLN E1345    CG   CD   OE1  NE2                                  
REMARK 470     ASP E1354    CG   OD1  OD2                                       
REMARK 470     LYS E1358    CG   CD   CE   NZ                                   
REMARK 470     GLN E1372    CG   CD   OE1  NE2                                  
REMARK 470     LYS E1373    CG   CD   CE   NZ                                   
REMARK 470     GLU E1442    CG   CD   OE1  OE2                                  
REMARK 470     ARG E1443    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E1444    CG   CD   CE   NZ                                   
REMARK 470     GLU E1476    CG   CD   OE1  OE2                                  
REMARK 470     LYS E1498    CG   CD   CE   NZ                                   
REMARK 470     GLU E1506    CG   CD   OE1  OE2                                  
REMARK 470     THR E1508    OG1  CG2                                            
REMARK 470     ARG E1530    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS E1537    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS E1552    CG   CD   CE   NZ                                   
REMARK 470     ARG E1553    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E1558    CG   CD   OE1  OE2                                  
REMARK 470     LYS E1561    CG   CD   CE   NZ                                   
REMARK 470     GLU E1563    CG   CD   OE1  OE2                                  
REMARK 470     LYS E1581    CG   CD   CE   NZ                                   
REMARK 470     SER H   8    OG                                                  
REMARK 470     GLU H   9    CG   CD   OE1  OE2                                  
REMARK 470     ASN H  10    CG   OD1  ND2                                       
REMARK 470     HIS H  11    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER H  12    OG                                                  
REMARK 470     TYR H  15    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN H  19    CG   CD   OE1  NE2                                  
REMARK 470     ASN H  72    CG   OD1  ND2                                       
REMARK 470     LEU H  73    CG   CD1  CD2                                       
REMARK 470     ILE H  76    CG1  CG2  CD1                                       
REMARK 470     MET H  80    CG   SD   CE                                        
REMARK 470     VAL H  86    CG1  CG2                                            
REMARK 470     GLU H  91    CG   CD   OE1  OE2                                  
REMARK 470     VAL H  98    CG1  CG2                                            
REMARK 470     THR H  99    OG1  CG2                                            
REMARK 470     GLU H 100    CG   CD   OE1  OE2                                  
REMARK 470     MET H 115    CG   SD   CE                                        
REMARK 470     ASN H 131    CG   OD1  ND2                                       
REMARK 470     ASP H 159    CG   OD1  OD2                                       
REMARK 470     HIS H 160    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE H 162    CG1  CG2  CD1                                       
REMARK 470     PHE H 164    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN H 166    CG   CD   OE1  NE2                                  
REMARK 470     LEU H 167    CG   CD1  CD2                                       
REMARK 470     ILE H 190    CG1  CG2  CD1                                       
REMARK 470     ARG H 191    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL H 192    CG1  CG2                                            
REMARK 470     ASN H 262    CG   OD1  ND2                                       
REMARK 470     TYR H 263    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN H 264    CG   CD   OE1  NE2                                  
REMARK 470     ARG H 265    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU H 266    CG   CD1  CD2                                       
REMARK 470     CYS H 267    SG                                                  
REMARK 470     GLU H 268    CG   CD   OE1  OE2                                  
REMARK 470     PHE H 270    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP H 271    CG   OD1  OD2                                       
REMARK 470     GLN H 273    CG   CD   OE1  NE2                                  
REMARK 470     VAL H 274    CG1  CG2                                            
REMARK 470     ARG H 275    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS H 276    CG   CD   CE   NZ                                   
REMARK 470     ASP H 277    CG   OD1  OD2                                       
REMARK 470     ARG H 486    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H 523    CG   CD   OE1  OE2                                  
REMARK 470     VAL H 587    CG1  CG2                                            
REMARK 470     THR H 588    OG1  CG2                                            
REMARK 470     PHE H 591    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG H 620    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP H 691    CG   OD1  OD2                                       
REMARK 470     ILE H 693    CG1  CG2  CD1                                       
REMARK 470     ARG H 705    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN H 731    CG   CD   OE1  NE2                                  
REMARK 470     SER H 740    OG                                                  
REMARK 470     ARG H 766    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H 784    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 785    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 790    CG   CD   OE1  OE2                                  
REMARK 470     SER H 791    OG                                                  
REMARK 470     GLN H 796    CG   CD   OE1  NE2                                  
REMARK 470     ARG H 797    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP H 812    CG   OD1  OD2                                       
REMARK 470     GLU H 824    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 825    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN H 828    CG   OD1  ND2                                       
REMARK 470     ASP H 879    CG   OD1  OD2                                       
REMARK 470     LYS H 880    CG   CD   CE   NZ                                   
REMARK 470     LYS H 903    CG   CD   CE   NZ                                   
REMARK 470     ASP H 904    CG   OD1  OD2                                       
REMARK 470     ARG H 909    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H 910    CG   CD   OE1  OE2                                  
REMARK 470     THR H 912    OG1  CG2                                            
REMARK 470     LEU H 913    CG   CD1  CD2                                       
REMARK 470     LYS H 914    CG   CD   CE   NZ                                   
REMARK 470     PHE H 916    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN H 917    CG   CD   OE1  NE2                                  
REMARK 470     SER H 919    OG                                                  
REMARK 470     GLU H 920    CG   CD   OE1  OE2                                  
REMARK 470     PHE H 924    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TRP H 927    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP H 927    CZ3  CH2                                            
REMARK 470     LYS H 928    CG   CD   CE   NZ                                   
REMARK 470     THR H 929    OG1  CG2                                            
REMARK 470     LEU H 930    CG   CD1  CD2                                       
REMARK 470     GLU H 994    CG   CD   OE1  OE2                                  
REMARK 470     ILE H 995    CG1  CG2  CD1                                       
REMARK 470     TRP H 997    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP H 997    CZ3  CH2                                            
REMARK 470     ARG H 998    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS H1002    CG   CD   CE   NZ                                   
REMARK 470     SER H1013    OG                                                  
REMARK 470     THR H1061    OG1  CG2                                            
REMARK 470     GLU H1086    CG   CD   OE1  OE2                                  
REMARK 470     ARG H1095    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG H1103    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H1113    CG   CD   OE1  OE2                                  
REMARK 470     SER H1276    OG                                                  
REMARK 470     LYS H1319    CG   CD   CE   NZ                                   
REMARK 470     GLU H1321    CG   CD   OE1  OE2                                  
REMARK 470     GLU H1323    CG   CD   OE1  OE2                                  
REMARK 470     SER H1324    OG                                                  
REMARK 470     GLU H1326    CG   CD   OE1  OE2                                  
REMARK 470     LEU H1328    CG   CD1  CD2                                       
REMARK 470     LEU H1329    CG   CD1  CD2                                       
REMARK 470     SER H1332    OG                                                  
REMARK 470     LEU H1333    CG   CD1  CD2                                       
REMARK 470     LYS H1336    CG   CD   CE   NZ                                   
REMARK 470     ASP H1340    CG   OD1  OD2                                       
REMARK 470     GLN H1341    CG   CD   OE1  NE2                                  
REMARK 470     GLN H1345    CG   CD   OE1  NE2                                  
REMARK 470     ASP H1354    CG   OD1  OD2                                       
REMARK 470     LYS H1358    CG   CD   CE   NZ                                   
REMARK 470     GLN H1372    CG   CD   OE1  NE2                                  
REMARK 470     LYS H1373    CG   CD   CE   NZ                                   
REMARK 470     GLU H1442    CG   CD   OE1  OE2                                  
REMARK 470     ARG H1443    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS H1444    CG   CD   CE   NZ                                   
REMARK 470     GLU H1476    CG   CD   OE1  OE2                                  
REMARK 470     LYS H1498    CG   CD   CE   NZ                                   
REMARK 470     GLU H1506    CG   CD   OE1  OE2                                  
REMARK 470     THR H1508    OG1  CG2                                            
REMARK 470     ARG H1530    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS H1537    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS H1552    CG   CD   CE   NZ                                   
REMARK 470     ARG H1553    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H1558    CG   CD   OE1  OE2                                  
REMARK 470     LYS H1561    CG   CD   CE   NZ                                   
REMARK 470     GLU H1563    CG   CD   OE1  OE2                                  
REMARK 470     LYS H1581    CG   CD   CE   NZ                                   
REMARK 470     SER G   8    OG                                                  
REMARK 470     GLU G   9    CG   CD   OE1  OE2                                  
REMARK 470     ASN G  10    CG   OD1  ND2                                       
REMARK 470     HIS G  11    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER G  12    OG                                                  
REMARK 470     TYR G  15    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN G  19    CG   CD   OE1  NE2                                  
REMARK 470     ASN G  72    CG   OD1  ND2                                       
REMARK 470     LEU G  73    CG   CD1  CD2                                       
REMARK 470     ILE G  76    CG1  CG2  CD1                                       
REMARK 470     MET G  80    CG   SD   CE                                        
REMARK 470     VAL G  86    CG1  CG2                                            
REMARK 470     GLU G  91    CG   CD   OE1  OE2                                  
REMARK 470     VAL G  98    CG1  CG2                                            
REMARK 470     THR G  99    OG1  CG2                                            
REMARK 470     GLU G 100    CG   CD   OE1  OE2                                  
REMARK 470     MET G 115    CG   SD   CE                                        
REMARK 470     ASN G 131    CG   OD1  ND2                                       
REMARK 470     ASP G 159    CG   OD1  OD2                                       
REMARK 470     HIS G 160    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE G 162    CG1  CG2  CD1                                       
REMARK 470     PHE G 164    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN G 166    CG   CD   OE1  NE2                                  
REMARK 470     LEU G 167    CG   CD1  CD2                                       
REMARK 470     ILE G 190    CG1  CG2  CD1                                       
REMARK 470     ARG G 191    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL G 192    CG1  CG2                                            
REMARK 470     ASN G 262    CG   OD1  ND2                                       
REMARK 470     TYR G 263    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN G 264    CG   CD   OE1  NE2                                  
REMARK 470     ARG G 265    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU G 266    CG   CD1  CD2                                       
REMARK 470     CYS G 267    SG                                                  
REMARK 470     GLU G 268    CG   CD   OE1  OE2                                  
REMARK 470     PHE G 270    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP G 271    CG   OD1  OD2                                       
REMARK 470     GLN G 273    CG   CD   OE1  NE2                                  
REMARK 470     VAL G 274    CG1  CG2                                            
REMARK 470     ARG G 275    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G 276    CG   CD   CE   NZ                                   
REMARK 470     ASP G 277    CG   OD1  OD2                                       
REMARK 470     ARG G 486    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G 523    CG   CD   OE1  OE2                                  
REMARK 470     VAL G 587    CG1  CG2                                            
REMARK 470     THR G 588    OG1  CG2                                            
REMARK 470     PHE G 591    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG G 620    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP G 691    CG   OD1  OD2                                       
REMARK 470     ILE G 693    CG1  CG2  CD1                                       
REMARK 470     ARG G 705    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN G 731    CG   CD   OE1  NE2                                  
REMARK 470     SER G 740    OG                                                  
REMARK 470     ARG G 766    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G 784    CG   CD   OE1  OE2                                  
REMARK 470     GLU G 785    CG   CD   OE1  OE2                                  
REMARK 470     GLU G 790    CG   CD   OE1  OE2                                  
REMARK 470     SER G 791    OG                                                  
REMARK 470     GLN G 796    CG   CD   OE1  NE2                                  
REMARK 470     ARG G 797    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP G 812    CG   OD1  OD2                                       
REMARK 470     GLU G 824    CG   CD   OE1  OE2                                  
REMARK 470     ARG G 825    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN G 828    CG   OD1  ND2                                       
REMARK 470     ASP G 879    CG   OD1  OD2                                       
REMARK 470     LYS G 880    CG   CD   CE   NZ                                   
REMARK 470     LYS G 903    CG   CD   CE   NZ                                   
REMARK 470     ASP G 904    CG   OD1  OD2                                       
REMARK 470     ARG G 909    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G 910    CG   CD   OE1  OE2                                  
REMARK 470     THR G 912    OG1  CG2                                            
REMARK 470     LEU G 913    CG   CD1  CD2                                       
REMARK 470     LYS G 914    CG   CD   CE   NZ                                   
REMARK 470     PHE G 916    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN G 917    CG   CD   OE1  NE2                                  
REMARK 470     SER G 919    OG                                                  
REMARK 470     GLU G 920    CG   CD   OE1  OE2                                  
REMARK 470     PHE G 924    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TRP G 927    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP G 927    CZ3  CH2                                            
REMARK 470     LYS G 928    CG   CD   CE   NZ                                   
REMARK 470     THR G 929    OG1  CG2                                            
REMARK 470     LEU G 930    CG   CD1  CD2                                       
REMARK 470     GLU G 994    CG   CD   OE1  OE2                                  
REMARK 470     ILE G 995    CG1  CG2  CD1                                       
REMARK 470     TRP G 997    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP G 997    CZ3  CH2                                            
REMARK 470     ARG G 998    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G1002    CG   CD   CE   NZ                                   
REMARK 470     SER G1013    OG                                                  
REMARK 470     THR G1061    OG1  CG2                                            
REMARK 470     GLU G1086    CG   CD   OE1  OE2                                  
REMARK 470     ARG G1095    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG G1103    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G1113    CG   CD   OE1  OE2                                  
REMARK 470     SER G1276    OG                                                  
REMARK 470     LYS G1319    CG   CD   CE   NZ                                   
REMARK 470     GLU G1321    CG   CD   OE1  OE2                                  
REMARK 470     GLU G1323    CG   CD   OE1  OE2                                  
REMARK 470     SER G1324    OG                                                  
REMARK 470     GLU G1326    CG   CD   OE1  OE2                                  
REMARK 470     LEU G1328    CG   CD1  CD2                                       
REMARK 470     LEU G1329    CG   CD1  CD2                                       
REMARK 470     SER G1332    OG                                                  
REMARK 470     LEU G1333    CG   CD1  CD2                                       
REMARK 470     LYS G1336    CG   CD   CE   NZ                                   
REMARK 470     ASP G1340    CG   OD1  OD2                                       
REMARK 470     GLN G1341    CG   CD   OE1  NE2                                  
REMARK 470     GLN G1345    CG   CD   OE1  NE2                                  
REMARK 470     ASP G1354    CG   OD1  OD2                                       
REMARK 470     LYS G1358    CG   CD   CE   NZ                                   
REMARK 470     GLN G1372    CG   CD   OE1  NE2                                  
REMARK 470     LYS G1373    CG   CD   CE   NZ                                   
REMARK 470     GLU G1442    CG   CD   OE1  OE2                                  
REMARK 470     ARG G1443    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G1444    CG   CD   CE   NZ                                   
REMARK 470     GLU G1476    CG   CD   OE1  OE2                                  
REMARK 470     LYS G1498    CG   CD   CE   NZ                                   
REMARK 470     GLU G1506    CG   CD   OE1  OE2                                  
REMARK 470     THR G1508    OG1  CG2                                            
REMARK 470     ARG G1530    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS G1537    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS G1552    CG   CD   CE   NZ                                   
REMARK 470     ARG G1553    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G1558    CG   CD   OE1  OE2                                  
REMARK 470     LYS G1561    CG   CD   CE   NZ                                   
REMARK 470     GLU G1563    CG   CD   OE1  OE2                                  
REMARK 470     LYS G1581    CG   CD   CE   NZ                                   
REMARK 470     SER F   8    OG                                                  
REMARK 470     GLU F   9    CG   CD   OE1  OE2                                  
REMARK 470     ASN F  10    CG   OD1  ND2                                       
REMARK 470     HIS F  11    CG   ND1  CD2  CE1  NE2                             
REMARK 470     SER F  12    OG                                                  
REMARK 470     TYR F  15    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN F  19    CG   CD   OE1  NE2                                  
REMARK 470     ASN F  72    CG   OD1  ND2                                       
REMARK 470     LEU F  73    CG   CD1  CD2                                       
REMARK 470     ILE F  76    CG1  CG2  CD1                                       
REMARK 470     MET F  80    CG   SD   CE                                        
REMARK 470     VAL F  86    CG1  CG2                                            
REMARK 470     GLU F  91    CG   CD   OE1  OE2                                  
REMARK 470     VAL F  98    CG1  CG2                                            
REMARK 470     THR F  99    OG1  CG2                                            
REMARK 470     GLU F 100    CG   CD   OE1  OE2                                  
REMARK 470     MET F 115    CG   SD   CE                                        
REMARK 470     ASN F 131    CG   OD1  ND2                                       
REMARK 470     ASP F 159    CG   OD1  OD2                                       
REMARK 470     HIS F 160    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE F 162    CG1  CG2  CD1                                       
REMARK 470     PHE F 164    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN F 166    CG   CD   OE1  NE2                                  
REMARK 470     LEU F 167    CG   CD1  CD2                                       
REMARK 470     ILE F 190    CG1  CG2  CD1                                       
REMARK 470     ARG F 191    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL F 192    CG1  CG2                                            
REMARK 470     ASN F 262    CG   OD1  ND2                                       
REMARK 470     TYR F 263    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN F 264    CG   CD   OE1  NE2                                  
REMARK 470     ARG F 265    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU F 266    CG   CD1  CD2                                       
REMARK 470     CYS F 267    SG                                                  
REMARK 470     GLU F 268    CG   CD   OE1  OE2                                  
REMARK 470     PHE F 270    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP F 271    CG   OD1  OD2                                       
REMARK 470     GLN F 273    CG   CD   OE1  NE2                                  
REMARK 470     VAL F 274    CG1  CG2                                            
REMARK 470     ARG F 275    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS F 276    CG   CD   CE   NZ                                   
REMARK 470     ASP F 277    CG   OD1  OD2                                       
REMARK 470     ARG F 486    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU F 523    CG   CD   OE1  OE2                                  
REMARK 470     VAL F 587    CG1  CG2                                            
REMARK 470     THR F 588    OG1  CG2                                            
REMARK 470     PHE F 591    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG F 620    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP F 691    CG   OD1  OD2                                       
REMARK 470     ILE F 693    CG1  CG2  CD1                                       
REMARK 470     ARG F 705    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN F 731    CG   CD   OE1  NE2                                  
REMARK 470     SER F 740    OG                                                  
REMARK 470     ARG F 766    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU F 784    CG   CD   OE1  OE2                                  
REMARK 470     GLU F 785    CG   CD   OE1  OE2                                  
REMARK 470     GLU F 790    CG   CD   OE1  OE2                                  
REMARK 470     SER F 791    OG                                                  
REMARK 470     GLN F 796    CG   CD   OE1  NE2                                  
REMARK 470     ARG F 797    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP F 812    CG   OD1  OD2                                       
REMARK 470     GLU F 824    CG   CD   OE1  OE2                                  
REMARK 470     ARG F 825    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN F 828    CG   OD1  ND2                                       
REMARK 470     ASP F 879    CG   OD1  OD2                                       
REMARK 470     LYS F 880    CG   CD   CE   NZ                                   
REMARK 470     LYS F 903    CG   CD   CE   NZ                                   
REMARK 470     ASP F 904    CG   OD1  OD2                                       
REMARK 470     ARG F 909    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU F 910    CG   CD   OE1  OE2                                  
REMARK 470     THR F 912    OG1  CG2                                            
REMARK 470     LEU F 913    CG   CD1  CD2                                       
REMARK 470     LYS F 914    CG   CD   CE   NZ                                   
REMARK 470     PHE F 916    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN F 917    CG   CD   OE1  NE2                                  
REMARK 470     SER F 919    OG                                                  
REMARK 470     GLU F 920    CG   CD   OE1  OE2                                  
REMARK 470     PHE F 924    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TRP F 927    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP F 927    CZ3  CH2                                            
REMARK 470     LYS F 928    CG   CD   CE   NZ                                   
REMARK 470     THR F 929    OG1  CG2                                            
REMARK 470     LEU F 930    CG   CD1  CD2                                       
REMARK 470     GLU F 994    CG   CD   OE1  OE2                                  
REMARK 470     ILE F 995    CG1  CG2  CD1                                       
REMARK 470     TRP F 997    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP F 997    CZ3  CH2                                            
REMARK 470     ARG F 998    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS F1002    CG   CD   CE   NZ                                   
REMARK 470     SER F1013    OG                                                  
REMARK 470     THR F1061    OG1  CG2                                            
REMARK 470     GLU F1086    CG   CD   OE1  OE2                                  
REMARK 470     ARG F1095    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG F1103    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU F1113    CG   CD   OE1  OE2                                  
REMARK 470     SER F1276    OG                                                  
REMARK 470     LYS F1319    CG   CD   CE   NZ                                   
REMARK 470     GLU F1321    CG   CD   OE1  OE2                                  
REMARK 470     GLU F1323    CG   CD   OE1  OE2                                  
REMARK 470     SER F1324    OG                                                  
REMARK 470     GLU F1326    CG   CD   OE1  OE2                                  
REMARK 470     LEU F1328    CG   CD1  CD2                                       
REMARK 470     LEU F1329    CG   CD1  CD2                                       
REMARK 470     SER F1332    OG                                                  
REMARK 470     LEU F1333    CG   CD1  CD2                                       
REMARK 470     LYS F1336    CG   CD   CE   NZ                                   
REMARK 470     ASP F1340    CG   OD1  OD2                                       
REMARK 470     GLN F1341    CG   CD   OE1  NE2                                  
REMARK 470     GLN F1345    CG   CD   OE1  NE2                                  
REMARK 470     ASP F1354    CG   OD1  OD2                                       
REMARK 470     LYS F1358    CG   CD   CE   NZ                                   
REMARK 470     GLN F1372    CG   CD   OE1  NE2                                  
REMARK 470     LYS F1373    CG   CD   CE   NZ                                   
REMARK 470     GLU F1442    CG   CD   OE1  OE2                                  
REMARK 470     ARG F1443    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS F1444    CG   CD   CE   NZ                                   
REMARK 470     GLU F1476    CG   CD   OE1  OE2                                  
REMARK 470     LYS F1498    CG   CD   CE   NZ                                   
REMARK 470     GLU F1506    CG   CD   OE1  OE2                                  
REMARK 470     THR F1508    OG1  CG2                                            
REMARK 470     ARG F1530    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS F1537    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS F1552    CG   CD   CE   NZ                                   
REMARK 470     ARG F1553    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU F1558    CG   CD   OE1  OE2                                  
REMARK 470     LYS F1561    CG   CD   CE   NZ                                   
REMARK 470     GLU F1563    CG   CD   OE1  OE2                                  
REMARK 470     LYS F1581    CG   CD   CE   NZ                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   ND1  HIS H   888     OD1  ASP H  1512              1.66            
REMARK 500   ND1  HIS F   888     OD1  ASP F  1512              1.66            
REMARK 500   ND1  HIS G   888     OD1  ASP G  1512              1.66            
REMARK 500   ND1  HIS E   888     OD1  ASP E  1512              1.66            
REMARK 500   OD1  ASP H   424     OG   SER H   606              2.01            
REMARK 500   OD1  ASP G   424     OG   SER G   606              2.01            
REMARK 500   OD1  ASP F   424     OG   SER F   606              2.01            
REMARK 500   OD1  ASP E   424     OG   SER E   606              2.01            
REMARK 500   O    ALA H   309     NE2  GLN H   369              2.08            
REMARK 500   O    ALA E   309     NE2  GLN E   369              2.08            
REMARK 500   O    ALA F   309     NE2  GLN F   369              2.08            
REMARK 500   O    ALA G   309     NE2  GLN G   369              2.08            
REMARK 500   OD1  ASP G   865     OH   TYR G   892              2.11            
REMARK 500   OD1  ASP E   865     OH   TYR E   892              2.11            
REMARK 500   OD1  ASP H   865     OH   TYR H   892              2.11            
REMARK 500   OD1  ASP F   865     OH   TYR F   892              2.11            
REMARK 500   OG   SER D   113     O    GLY D   135              2.12            
REMARK 500   OG   SER C   113     O    GLY C   135              2.12            
REMARK 500   OG   SER A   113     O    GLY A   135              2.12            
REMARK 500   OG   SER B   113     O    GLY B   135              2.12            
REMARK 500   OG   SER A   119     OE2  GLU B   140              2.17            
REMARK 500   O    ALA G   117     OG   SER G   120              2.17            
REMARK 500   O    ALA H   117     OG   SER H   120              2.17            
REMARK 500   O    VAL G  1429     NH1  ARG G  1493              2.17            
REMARK 500   OD2  ASP H    29     ND1  HIS H   105              2.17            
REMARK 500   O    ALA E   117     OG   SER E   120              2.17            
REMARK 500   O    ALA F   117     OG   SER F   120              2.17            
REMARK 500   OD2  ASP F    29     ND1  HIS F   105              2.17            
REMARK 500   OD2  ASP E    29     ND1  HIS E   105              2.17            
REMARK 500   O    VAL H  1429     NH1  ARG H  1493              2.17            
REMARK 500   O    VAL F  1429     NH1  ARG F  1493              2.17            
REMARK 500   OD2  ASP G    29     ND1  HIS G   105              2.17            
REMARK 500   O    VAL E  1429     NH1  ARG E  1493              2.18            
REMARK 500   NH2  ARG A   136     O    VAL B   138              2.18            
REMARK 500   O    ALA E   380     OG1  THR E   383              2.18            
REMARK 500   O    ALA F   380     OG1  THR F   383              2.18            
REMARK 500   O    ALA H   380     OG1  THR H   383              2.18            
REMARK 500   O    ALA G   380     OG1  THR G   383              2.18            
REMARK 500   O    PHE D    75     OG   SER D    78              2.19            
REMARK 500   O    PHE C    75     OG   SER C    78              2.19            
REMARK 500   O    PHE B    75     OG   SER B    78              2.19            
REMARK 500   O    PHE A    75     OG   SER A    78              2.19            
REMARK 500   OG   SER G  1482     O3A  ATP G  2004              2.19            
REMARK 500   OG   SER E  1482     O3A  ATP E  2004              2.19            
REMARK 500   OG   SER F  1482     O3A  ATP F  2004              2.19            
REMARK 500   OG   SER H  1482     O3A  ATP H  2004              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    HIS A 175       -4.35     66.82                                   
REMARK 500    SER A 273       -3.89     66.89                                   
REMARK 500    ASP A 323       80.20    -68.00                                   
REMARK 500    HIS C 175       -4.42     66.90                                   
REMARK 500    SER C 273       -3.92     66.95                                   
REMARK 500    ASP C 323       80.09    -67.97                                   
REMARK 500    HIS B 175       -4.43     66.98                                   
REMARK 500    SER B 273       -3.93     66.94                                   
REMARK 500    ASP B 323       80.14    -68.02                                   
REMARK 500    HIS D 175       -4.43     66.95                                   
REMARK 500    SER D 273       -3.93     66.96                                   
REMARK 500    ASP D 323       80.09    -68.04                                   
REMARK 500    CYS E   6       30.10   -141.10                                   
REMARK 500    GLU E   9     -168.03   -128.40                                   
REMARK 500    ASN E 131      -65.62    -94.82                                   
REMARK 500    PHE E 132      144.73   -173.29                                   
REMARK 500    LEU E 136        4.25    -66.58                                   
REMARK 500    MET E 409      -64.34    -93.99                                   
REMARK 500    GLU E 411      -53.27   -123.29                                   
REMARK 500    LEU E 456       -0.36     58.25                                   
REMARK 500    LEU E 461       72.01   -100.82                                   
REMARK 500    CYS E 678     -161.50    -79.54                                   
REMARK 500    PHE E 851      116.55   -162.07                                   
REMARK 500    TYR E 892       51.76    -94.80                                   
REMARK 500    PRO E 894       39.84    -77.55                                   
REMARK 500    SER E1276      177.39    177.39                                   
REMARK 500    ASP E1340     -163.09    -78.46                                   
REMARK 500    PRO E1370     -173.32    -67.16                                   
REMARK 500    GLN E1372       -9.65     72.43                                   
REMARK 500    ARG E1393       15.83     55.84                                   
REMARK 500    THR E1397       59.06     36.34                                   
REMARK 500    ASP E1405       55.83     33.64                                   
REMARK 500    ARG E1443       33.14    -94.32                                   
REMARK 500    LYS E1444       76.46   -117.01                                   
REMARK 500    CYS E1445      117.02   -161.86                                   
REMARK 500    LYS E1498       33.61    -94.90                                   
REMARK 500    LYS E1569       -9.89     70.98                                   
REMARK 500    CYS H   6       30.15   -141.17                                   
REMARK 500    GLU H   9     -168.04   -128.40                                   
REMARK 500    ASN H 131      -65.70    -94.82                                   
REMARK 500    PHE H 132      144.77   -173.21                                   
REMARK 500    LEU H 136        4.24    -66.55                                   
REMARK 500    MET H 409      -64.30    -94.09                                   
REMARK 500    GLU H 411      -53.36   -123.25                                   
REMARK 500    LEU H 456       -0.52     58.32                                   
REMARK 500    LEU H 461       71.97   -100.77                                   
REMARK 500    CYS H 678     -161.48    -79.57                                   
REMARK 500    PHE H 851      116.47   -162.14                                   
REMARK 500    TYR H 892       51.60    -94.82                                   
REMARK 500    PRO H 894       39.82    -77.49                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     112 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                               K A 504   K                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR A 130   O                                                      
REMARK 620 2 THR A 130   OG1  59.9                                              
REMARK 620 3 THR C 130   O   103.7 162.7                                        
REMARK 620 4 THR C 130   OG1 161.5 138.5  58.3                                  
REMARK 620 5 THR B 130   O    66.5 105.4  69.3 100.5                            
REMARK 620 6 THR B 130   OG1  99.4  81.0 108.7  84.1  60.8                      
REMARK 620 7 THR D 130   O    68.9 101.0  65.8 103.6 103.9 164.2                
REMARK 620 8 THR D 130   OG1 108.2  83.6  97.9  80.4 163.3 135.6  60.0          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                               K A 503   K                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ILE A 131   O                                                      
REMARK 620 2 GLY A 132   O    62.1                                              
REMARK 620 3 ILE C 131   O   131.9 157.9                                        
REMARK 620 4 GLY C 132   O   158.1 113.0  60.9                                  
REMARK 620 5 ILE B 131   O    77.8 120.9  81.0  88.6                            
REMARK 620 6 GLY B 132   O    84.3  70.7 122.8  74.2  63.5                      
REMARK 620 7 ILE D 131   O    80.8  88.1  79.1 121.0 127.8 158.0                
REMARK 620 8 GLY D 132   O   123.4  73.8  84.3  70.8 158.7 113.6  63.3          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                               K A 502   K                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 PHE A 133   O                                                      
REMARK 620 2 PHE C 133   O    96.3                                              
REMARK 620 3 PHE B 133   O    60.9  63.4                                        
REMARK 620 4 PHE D 133   O    63.0  61.7  91.5                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG E2002  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER E 720   OG                                                     
REMARK 620 2 GLN E 774   OE1  78.3                                              
REMARK 620 3 ATP E2004   O3A 123.8 151.6                                        
REMARK 620 4 ATP E2004   O1B  73.0 150.2  57.3                                  
REMARK 620 5 ATP E2004   O3B 140.5 121.8  54.4  78.4                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG H2002  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER H 720   OG                                                     
REMARK 620 2 GLN H 774   OE1  78.3                                              
REMARK 620 3 ATP H2004   O3A 123.8 151.5                                        
REMARK 620 4 ATP H2004   O3B 140.5 121.8  54.4                                  
REMARK 620 5 ATP H2004   O1B  73.0 150.2  57.3  78.4                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG G2002  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER G 720   OG                                                     
REMARK 620 2 GLN G 774   OE1  78.3                                              
REMARK 620 3 ATP G2004   O3A 123.8 151.5                                        
REMARK 620 4 ATP G2004   O3B 140.6 121.8  54.4                                  
REMARK 620 5 ATP G2004   O1B  73.0 150.2  57.2  78.4                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG F2002  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER F 720   OG                                                     
REMARK 620 2 GLN F 774   OE1  78.3                                              
REMARK 620 3 ATP F2004   O3A 123.8 151.5                                        
REMARK 620 4 ATP F2004   O1B  73.0 150.2  57.3                                  
REMARK 620 5 ATP F2004   O3B 140.6 121.8  54.4  78.4                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG E2003  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ADP E2001   O1B                                                    
REMARK 620 2 ADP E2001   O1A 115.5                                              
REMARK 620 3 ADP E2001   O3A  75.3  60.0                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG H2003  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ADP H2001   O1B                                                    
REMARK 620 2 ADP H2001   O1A 115.5                                              
REMARK 620 3 ADP H2001   O3A  75.3  60.0                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG G2003  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ADP G2001   O1B                                                    
REMARK 620 2 ADP G2001   O1A 115.5                                              
REMARK 620 3 ADP G2001   O3A  75.4  60.0                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG F2003  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ADP F2001   O1B                                                    
REMARK 620 2 ADP F2001   O1A 115.5                                              
REMARK 620 3 ADP F2001   O3A  75.3  60.0                                        
REMARK 620 N                    1     2                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP A 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue K A 502                   
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue K A 503                   
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue K A 504                   
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP C 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP B 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP D 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP E 2001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG E 2002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG E 2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP E 2004                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP H 2001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG H 2002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG H 2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP H 2004                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP G 2001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG G 2002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG G 2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP G 2004                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP F 2001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG F 2002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG F 2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP F 2004                
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-7338   RELATED DB: EMDB                              
REMARK 900 CRYO-EM STRUCTURE OF HUMAN KATP BOUND TO ATP AND ADP IN QUATREFOIL   
REMARK 900 FORM                                                                 
DBREF  6C3O A    1   390  UNP    Q14654   KCJ11_HUMAN      1    390             
DBREF  6C3O C    1   390  UNP    Q14654   KCJ11_HUMAN      1    390             
DBREF  6C3O B    1   390  UNP    Q14654   KCJ11_HUMAN      1    390             
DBREF  6C3O D    1   390  UNP    Q14654   KCJ11_HUMAN      1    390             
DBREF  6C3O E    1  1581  UNP    Q09428   ABCC8_HUMAN      1   1581             
DBREF  6C3O H    1  1581  UNP    Q09428   ABCC8_HUMAN      1   1581             
DBREF  6C3O G    1  1581  UNP    Q09428   ABCC8_HUMAN      1   1581             
DBREF  6C3O F    1  1581  UNP    Q09428   ABCC8_HUMAN      1   1581             
SEQADV 6C3O SER A   -5  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA A   -4  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER A   -3  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA A   -2  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER A   -1  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA A    0  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER A  391  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ASN A  392  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER A  393  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O LEU A  394  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLU A  395  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O VAL A  396  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O LEU A  397  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O PHE A  398  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLN A  399  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLY A  400  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER C   -5  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA C   -4  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER C   -3  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA C   -2  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER C   -1  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA C    0  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER C  391  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ASN C  392  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER C  393  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O LEU C  394  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLU C  395  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O VAL C  396  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O LEU C  397  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O PHE C  398  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLN C  399  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLY C  400  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER B   -5  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA B   -4  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER B   -3  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA B   -2  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER B   -1  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA B    0  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER B  391  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ASN B  392  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER B  393  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O LEU B  394  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLU B  395  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O VAL B  396  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O LEU B  397  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O PHE B  398  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLN B  399  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLY B  400  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER D   -5  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA D   -4  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER D   -3  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA D   -2  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER D   -1  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ALA D    0  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER D  391  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O ASN D  392  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O SER D  393  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O LEU D  394  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLU D  395  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O VAL D  396  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O LEU D  397  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O PHE D  398  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLN D  399  UNP  Q14654              EXPRESSION TAG                 
SEQADV 6C3O GLY D  400  UNP  Q14654              EXPRESSION TAG                 
SEQRES   1 A  406  SER ALA SER ALA SER ALA MET LEU SER ARG LYS GLY ILE          
SEQRES   2 A  406  ILE PRO GLU GLU TYR VAL LEU THR ARG LEU ALA GLU ASP          
SEQRES   3 A  406  PRO ALA GLU PRO ARG TYR ARG ALA ARG GLN ARG ARG ALA          
SEQRES   4 A  406  ARG PHE VAL SER LYS LYS GLY ASN CYS ASN VAL ALA HIS          
SEQRES   5 A  406  LYS ASN ILE ARG GLU GLN GLY ARG PHE LEU GLN ASP VAL          
SEQRES   6 A  406  PHE THR THR LEU VAL ASP LEU LYS TRP PRO HIS THR LEU          
SEQRES   7 A  406  LEU ILE PHE THR MET SER PHE LEU CYS SER TRP LEU LEU          
SEQRES   8 A  406  PHE ALA MET ALA TRP TRP LEU ILE ALA PHE ALA HIS GLY          
SEQRES   9 A  406  ASP LEU ALA PRO SER GLU GLY THR ALA GLU PRO CYS VAL          
SEQRES  10 A  406  THR SER ILE HIS SER PHE SER SER ALA PHE LEU PHE SER          
SEQRES  11 A  406  ILE GLU VAL GLN VAL THR ILE GLY PHE GLY GLY ARG MET          
SEQRES  12 A  406  VAL THR GLU GLU CYS PRO LEU ALA ILE LEU ILE LEU ILE          
SEQRES  13 A  406  VAL GLN ASN ILE VAL GLY LEU MET ILE ASN ALA ILE MET          
SEQRES  14 A  406  LEU GLY CYS ILE PHE MET LYS THR ALA GLN ALA HIS ARG          
SEQRES  15 A  406  ARG ALA GLU THR LEU ILE PHE SER LYS HIS ALA VAL ILE          
SEQRES  16 A  406  ALA LEU ARG HIS GLY ARG LEU CYS PHE MET LEU ARG VAL          
SEQRES  17 A  406  GLY ASP LEU ARG LYS SER MET ILE ILE SER ALA THR ILE          
SEQRES  18 A  406  HIS MET GLN VAL VAL ARG LYS THR THR SER PRO GLU GLY          
SEQRES  19 A  406  GLU VAL VAL PRO LEU HIS GLN VAL ASP ILE PRO MET GLU          
SEQRES  20 A  406  ASN GLY VAL GLY GLY ASN SER ILE PHE LEU VAL ALA PRO          
SEQRES  21 A  406  LEU ILE ILE TYR HIS VAL ILE ASP ALA ASN SER PRO LEU          
SEQRES  22 A  406  TYR ASP LEU ALA PRO SER ASP LEU HIS HIS HIS GLN ASP          
SEQRES  23 A  406  LEU GLU ILE ILE VAL ILE LEU GLU GLY VAL VAL GLU THR          
SEQRES  24 A  406  THR GLY ILE THR THR GLN ALA ARG THR SER TYR LEU ALA          
SEQRES  25 A  406  ASP GLU ILE LEU TRP GLY GLN ARG PHE VAL PRO ILE VAL          
SEQRES  26 A  406  ALA GLU GLU ASP GLY ARG TYR SER VAL ASP TYR SER LYS          
SEQRES  27 A  406  PHE GLY ASN THR ILE LYS VAL PRO THR PRO LEU CYS THR          
SEQRES  28 A  406  ALA ARG GLN LEU ASP GLU ASP HIS SER LEU LEU GLU ALA          
SEQRES  29 A  406  LEU THR LEU ALA SER ALA ARG GLY PRO LEU ARG LYS ARG          
SEQRES  30 A  406  SER VAL PRO MET ALA LYS ALA LYS PRO LYS PHE SER ILE          
SEQRES  31 A  406  SER PRO ASP SER LEU SER SER ASN SER LEU GLU VAL LEU          
SEQRES  32 A  406  PHE GLN GLY                                                  
SEQRES   1 C  406  SER ALA SER ALA SER ALA MET LEU SER ARG LYS GLY ILE          
SEQRES   2 C  406  ILE PRO GLU GLU TYR VAL LEU THR ARG LEU ALA GLU ASP          
SEQRES   3 C  406  PRO ALA GLU PRO ARG TYR ARG ALA ARG GLN ARG ARG ALA          
SEQRES   4 C  406  ARG PHE VAL SER LYS LYS GLY ASN CYS ASN VAL ALA HIS          
SEQRES   5 C  406  LYS ASN ILE ARG GLU GLN GLY ARG PHE LEU GLN ASP VAL          
SEQRES   6 C  406  PHE THR THR LEU VAL ASP LEU LYS TRP PRO HIS THR LEU          
SEQRES   7 C  406  LEU ILE PHE THR MET SER PHE LEU CYS SER TRP LEU LEU          
SEQRES   8 C  406  PHE ALA MET ALA TRP TRP LEU ILE ALA PHE ALA HIS GLY          
SEQRES   9 C  406  ASP LEU ALA PRO SER GLU GLY THR ALA GLU PRO CYS VAL          
SEQRES  10 C  406  THR SER ILE HIS SER PHE SER SER ALA PHE LEU PHE SER          
SEQRES  11 C  406  ILE GLU VAL GLN VAL THR ILE GLY PHE GLY GLY ARG MET          
SEQRES  12 C  406  VAL THR GLU GLU CYS PRO LEU ALA ILE LEU ILE LEU ILE          
SEQRES  13 C  406  VAL GLN ASN ILE VAL GLY LEU MET ILE ASN ALA ILE MET          
SEQRES  14 C  406  LEU GLY CYS ILE PHE MET LYS THR ALA GLN ALA HIS ARG          
SEQRES  15 C  406  ARG ALA GLU THR LEU ILE PHE SER LYS HIS ALA VAL ILE          
SEQRES  16 C  406  ALA LEU ARG HIS GLY ARG LEU CYS PHE MET LEU ARG VAL          
SEQRES  17 C  406  GLY ASP LEU ARG LYS SER MET ILE ILE SER ALA THR ILE          
SEQRES  18 C  406  HIS MET GLN VAL VAL ARG LYS THR THR SER PRO GLU GLY          
SEQRES  19 C  406  GLU VAL VAL PRO LEU HIS GLN VAL ASP ILE PRO MET GLU          
SEQRES  20 C  406  ASN GLY VAL GLY GLY ASN SER ILE PHE LEU VAL ALA PRO          
SEQRES  21 C  406  LEU ILE ILE TYR HIS VAL ILE ASP ALA ASN SER PRO LEU          
SEQRES  22 C  406  TYR ASP LEU ALA PRO SER ASP LEU HIS HIS HIS GLN ASP          
SEQRES  23 C  406  LEU GLU ILE ILE VAL ILE LEU GLU GLY VAL VAL GLU THR          
SEQRES  24 C  406  THR GLY ILE THR THR GLN ALA ARG THR SER TYR LEU ALA          
SEQRES  25 C  406  ASP GLU ILE LEU TRP GLY GLN ARG PHE VAL PRO ILE VAL          
SEQRES  26 C  406  ALA GLU GLU ASP GLY ARG TYR SER VAL ASP TYR SER LYS          
SEQRES  27 C  406  PHE GLY ASN THR ILE LYS VAL PRO THR PRO LEU CYS THR          
SEQRES  28 C  406  ALA ARG GLN LEU ASP GLU ASP HIS SER LEU LEU GLU ALA          
SEQRES  29 C  406  LEU THR LEU ALA SER ALA ARG GLY PRO LEU ARG LYS ARG          
SEQRES  30 C  406  SER VAL PRO MET ALA LYS ALA LYS PRO LYS PHE SER ILE          
SEQRES  31 C  406  SER PRO ASP SER LEU SER SER ASN SER LEU GLU VAL LEU          
SEQRES  32 C  406  PHE GLN GLY                                                  
SEQRES   1 B  406  SER ALA SER ALA SER ALA MET LEU SER ARG LYS GLY ILE          
SEQRES   2 B  406  ILE PRO GLU GLU TYR VAL LEU THR ARG LEU ALA GLU ASP          
SEQRES   3 B  406  PRO ALA GLU PRO ARG TYR ARG ALA ARG GLN ARG ARG ALA          
SEQRES   4 B  406  ARG PHE VAL SER LYS LYS GLY ASN CYS ASN VAL ALA HIS          
SEQRES   5 B  406  LYS ASN ILE ARG GLU GLN GLY ARG PHE LEU GLN ASP VAL          
SEQRES   6 B  406  PHE THR THR LEU VAL ASP LEU LYS TRP PRO HIS THR LEU          
SEQRES   7 B  406  LEU ILE PHE THR MET SER PHE LEU CYS SER TRP LEU LEU          
SEQRES   8 B  406  PHE ALA MET ALA TRP TRP LEU ILE ALA PHE ALA HIS GLY          
SEQRES   9 B  406  ASP LEU ALA PRO SER GLU GLY THR ALA GLU PRO CYS VAL          
SEQRES  10 B  406  THR SER ILE HIS SER PHE SER SER ALA PHE LEU PHE SER          
SEQRES  11 B  406  ILE GLU VAL GLN VAL THR ILE GLY PHE GLY GLY ARG MET          
SEQRES  12 B  406  VAL THR GLU GLU CYS PRO LEU ALA ILE LEU ILE LEU ILE          
SEQRES  13 B  406  VAL GLN ASN ILE VAL GLY LEU MET ILE ASN ALA ILE MET          
SEQRES  14 B  406  LEU GLY CYS ILE PHE MET LYS THR ALA GLN ALA HIS ARG          
SEQRES  15 B  406  ARG ALA GLU THR LEU ILE PHE SER LYS HIS ALA VAL ILE          
SEQRES  16 B  406  ALA LEU ARG HIS GLY ARG LEU CYS PHE MET LEU ARG VAL          
SEQRES  17 B  406  GLY ASP LEU ARG LYS SER MET ILE ILE SER ALA THR ILE          
SEQRES  18 B  406  HIS MET GLN VAL VAL ARG LYS THR THR SER PRO GLU GLY          
SEQRES  19 B  406  GLU VAL VAL PRO LEU HIS GLN VAL ASP ILE PRO MET GLU          
SEQRES  20 B  406  ASN GLY VAL GLY GLY ASN SER ILE PHE LEU VAL ALA PRO          
SEQRES  21 B  406  LEU ILE ILE TYR HIS VAL ILE ASP ALA ASN SER PRO LEU          
SEQRES  22 B  406  TYR ASP LEU ALA PRO SER ASP LEU HIS HIS HIS GLN ASP          
SEQRES  23 B  406  LEU GLU ILE ILE VAL ILE LEU GLU GLY VAL VAL GLU THR          
SEQRES  24 B  406  THR GLY ILE THR THR GLN ALA ARG THR SER TYR LEU ALA          
SEQRES  25 B  406  ASP GLU ILE LEU TRP GLY GLN ARG PHE VAL PRO ILE VAL          
SEQRES  26 B  406  ALA GLU GLU ASP GLY ARG TYR SER VAL ASP TYR SER LYS          
SEQRES  27 B  406  PHE GLY ASN THR ILE LYS VAL PRO THR PRO LEU CYS THR          
SEQRES  28 B  406  ALA ARG GLN LEU ASP GLU ASP HIS SER LEU LEU GLU ALA          
SEQRES  29 B  406  LEU THR LEU ALA SER ALA ARG GLY PRO LEU ARG LYS ARG          
SEQRES  30 B  406  SER VAL PRO MET ALA LYS ALA LYS PRO LYS PHE SER ILE          
SEQRES  31 B  406  SER PRO ASP SER LEU SER SER ASN SER LEU GLU VAL LEU          
SEQRES  32 B  406  PHE GLN GLY                                                  
SEQRES   1 D  406  SER ALA SER ALA SER ALA MET LEU SER ARG LYS GLY ILE          
SEQRES   2 D  406  ILE PRO GLU GLU TYR VAL LEU THR ARG LEU ALA GLU ASP          
SEQRES   3 D  406  PRO ALA GLU PRO ARG TYR ARG ALA ARG GLN ARG ARG ALA          
SEQRES   4 D  406  ARG PHE VAL SER LYS LYS GLY ASN CYS ASN VAL ALA HIS          
SEQRES   5 D  406  LYS ASN ILE ARG GLU GLN GLY ARG PHE LEU GLN ASP VAL          
SEQRES   6 D  406  PHE THR THR LEU VAL ASP LEU LYS TRP PRO HIS THR LEU          
SEQRES   7 D  406  LEU ILE PHE THR MET SER PHE LEU CYS SER TRP LEU LEU          
SEQRES   8 D  406  PHE ALA MET ALA TRP TRP LEU ILE ALA PHE ALA HIS GLY          
SEQRES   9 D  406  ASP LEU ALA PRO SER GLU GLY THR ALA GLU PRO CYS VAL          
SEQRES  10 D  406  THR SER ILE HIS SER PHE SER SER ALA PHE LEU PHE SER          
SEQRES  11 D  406  ILE GLU VAL GLN VAL THR ILE GLY PHE GLY GLY ARG MET          
SEQRES  12 D  406  VAL THR GLU GLU CYS PRO LEU ALA ILE LEU ILE LEU ILE          
SEQRES  13 D  406  VAL GLN ASN ILE VAL GLY LEU MET ILE ASN ALA ILE MET          
SEQRES  14 D  406  LEU GLY CYS ILE PHE MET LYS THR ALA GLN ALA HIS ARG          
SEQRES  15 D  406  ARG ALA GLU THR LEU ILE PHE SER LYS HIS ALA VAL ILE          
SEQRES  16 D  406  ALA LEU ARG HIS GLY ARG LEU CYS PHE MET LEU ARG VAL          
SEQRES  17 D  406  GLY ASP LEU ARG LYS SER MET ILE ILE SER ALA THR ILE          
SEQRES  18 D  406  HIS MET GLN VAL VAL ARG LYS THR THR SER PRO GLU GLY          
SEQRES  19 D  406  GLU VAL VAL PRO LEU HIS GLN VAL ASP ILE PRO MET GLU          
SEQRES  20 D  406  ASN GLY VAL GLY GLY ASN SER ILE PHE LEU VAL ALA PRO          
SEQRES  21 D  406  LEU ILE ILE TYR HIS VAL ILE ASP ALA ASN SER PRO LEU          
SEQRES  22 D  406  TYR ASP LEU ALA PRO SER ASP LEU HIS HIS HIS GLN ASP          
SEQRES  23 D  406  LEU GLU ILE ILE VAL ILE LEU GLU GLY VAL VAL GLU THR          
SEQRES  24 D  406  THR GLY ILE THR THR GLN ALA ARG THR SER TYR LEU ALA          
SEQRES  25 D  406  ASP GLU ILE LEU TRP GLY GLN ARG PHE VAL PRO ILE VAL          
SEQRES  26 D  406  ALA GLU GLU ASP GLY ARG TYR SER VAL ASP TYR SER LYS          
SEQRES  27 D  406  PHE GLY ASN THR ILE LYS VAL PRO THR PRO LEU CYS THR          
SEQRES  28 D  406  ALA ARG GLN LEU ASP GLU ASP HIS SER LEU LEU GLU ALA          
SEQRES  29 D  406  LEU THR LEU ALA SER ALA ARG GLY PRO LEU ARG LYS ARG          
SEQRES  30 D  406  SER VAL PRO MET ALA LYS ALA LYS PRO LYS PHE SER ILE          
SEQRES  31 D  406  SER PRO ASP SER LEU SER SER ASN SER LEU GLU VAL LEU          
SEQRES  32 D  406  PHE GLN GLY                                                  
SEQRES   1 E 1581  MET PRO LEU ALA PHE CYS GLY SER GLU ASN HIS SER ALA          
SEQRES   2 E 1581  ALA TYR ARG VAL ASP GLN GLY VAL LEU ASN ASN GLY CYS          
SEQRES   3 E 1581  PHE VAL ASP ALA LEU ASN VAL VAL PRO HIS VAL PHE LEU          
SEQRES   4 E 1581  LEU PHE ILE THR PHE PRO ILE LEU PHE ILE GLY TRP GLY          
SEQRES   5 E 1581  SER GLN SER SER LYS VAL HIS ILE HIS HIS SER THR TRP          
SEQRES   6 E 1581  LEU HIS PHE PRO GLY HIS ASN LEU ARG TRP ILE LEU THR          
SEQRES   7 E 1581  PHE MET LEU LEU PHE VAL LEU VAL CYS GLU ILE ALA GLU          
SEQRES   8 E 1581  GLY ILE LEU SER ASP GLY VAL THR GLU SER HIS HIS LEU          
SEQRES   9 E 1581  HIS LEU TYR MET PRO ALA GLY MET ALA PHE MET ALA ALA          
SEQRES  10 E 1581  VAL THR SER VAL VAL TYR TYR HIS ASN ILE GLU THR SER          
SEQRES  11 E 1581  ASN PHE PRO LYS LEU LEU ILE ALA LEU LEU VAL TYR TRP          
SEQRES  12 E 1581  THR LEU ALA PHE ILE THR LYS THR ILE LYS PHE VAL LYS          
SEQRES  13 E 1581  PHE LEU ASP HIS ALA ILE GLY PHE SER GLN LEU ARG PHE          
SEQRES  14 E 1581  CYS LEU THR GLY LEU LEU VAL ILE LEU TYR GLY MET LEU          
SEQRES  15 E 1581  LEU LEU VAL GLU VAL ASN VAL ILE ARG VAL ARG ARG TYR          
SEQRES  16 E 1581  ILE PHE PHE LYS THR PRO ARG GLU VAL LYS PRO PRO GLU          
SEQRES  17 E 1581  ASP LEU GLN ASP LEU GLY VAL ARG PHE LEU GLN PRO PHE          
SEQRES  18 E 1581  VAL ASN LEU LEU SER LYS GLY THR TYR TRP TRP MET ASN          
SEQRES  19 E 1581  ALA PHE ILE LYS THR ALA HIS LYS LYS PRO ILE ASP LEU          
SEQRES  20 E 1581  ARG ALA ILE GLY LYS LEU PRO ILE ALA MET ARG ALA LEU          
SEQRES  21 E 1581  THR ASN TYR GLN ARG LEU CYS GLU ALA PHE ASP ALA GLN          
SEQRES  22 E 1581  VAL ARG LYS ASP ILE GLN GLY THR GLN GLY ALA ARG ALA          
SEQRES  23 E 1581  ILE TRP GLN ALA LEU SER HIS ALA PHE GLY ARG ARG LEU          
SEQRES  24 E 1581  VAL LEU SER SER THR PHE ARG ILE LEU ALA ASP LEU LEU          
SEQRES  25 E 1581  GLY PHE ALA GLY PRO LEU CYS ILE PHE GLY ILE VAL ASP          
SEQRES  26 E 1581  HIS LEU GLY LYS GLU ASN ASP VAL PHE GLN PRO LYS THR          
SEQRES  27 E 1581  GLN PHE LEU GLY VAL TYR PHE VAL SER SER GLN GLU PHE          
SEQRES  28 E 1581  LEU ALA ASN ALA TYR VAL LEU ALA VAL LEU LEU PHE LEU          
SEQRES  29 E 1581  ALA LEU LEU LEU GLN ARG THR PHE LEU GLN ALA SER TYR          
SEQRES  30 E 1581  TYR VAL ALA ILE GLU THR GLY ILE ASN LEU ARG GLY ALA          
SEQRES  31 E 1581  ILE GLN THR LYS ILE TYR ASN LYS ILE MET HIS LEU SER          
SEQRES  32 E 1581  THR SER ASN LEU SER MET GLY GLU MET THR ALA GLY GLN          
SEQRES  33 E 1581  ILE CYS ASN LEU VAL ALA ILE ASP THR ASN GLN LEU MET          
SEQRES  34 E 1581  TRP PHE PHE PHE LEU CYS PRO ASN LEU TRP ALA MET PRO          
SEQRES  35 E 1581  VAL GLN ILE ILE VAL GLY VAL ILE LEU LEU TYR TYR ILE          
SEQRES  36 E 1581  LEU GLY VAL SER ALA LEU ILE GLY ALA ALA VAL ILE ILE          
SEQRES  37 E 1581  LEU LEU ALA PRO VAL GLN TYR PHE VAL ALA THR LYS LEU          
SEQRES  38 E 1581  SER GLN ALA GLN ARG SER THR LEU GLU TYR SER ASN GLU          
SEQRES  39 E 1581  ARG LEU LYS GLN THR ASN GLU MET LEU ARG GLY ILE LYS          
SEQRES  40 E 1581  LEU LEU LYS LEU TYR ALA TRP GLU ASN ILE PHE ARG THR          
SEQRES  41 E 1581  ARG VAL GLU THR THR ARG ARG LYS GLU MET THR SER LEU          
SEQRES  42 E 1581  ARG ALA PHE ALA ILE TYR THR SER ILE SER ILE PHE MET          
SEQRES  43 E 1581  ASN THR ALA ILE PRO ILE ALA ALA VAL LEU ILE THR PHE          
SEQRES  44 E 1581  VAL GLY HIS VAL SER PHE PHE LYS GLU ALA ASP PHE SER          
SEQRES  45 E 1581  PRO SER VAL ALA PHE ALA SER LEU SER LEU PHE HIS ILE          
SEQRES  46 E 1581  LEU VAL THR PRO LEU PHE LEU LEU SER SER VAL VAL ARG          
SEQRES  47 E 1581  SER THR VAL LYS ALA LEU VAL SER VAL GLN LYS LEU SER          
SEQRES  48 E 1581  GLU PHE LEU SER SER ALA GLU ILE ARG GLU GLU GLN CYS          
SEQRES  49 E 1581  ALA PRO HIS GLU PRO THR PRO GLN GLY PRO ALA SER LYS          
SEQRES  50 E 1581  TYR GLN ALA VAL PRO LEU ARG VAL VAL ASN ARG LYS ARG          
SEQRES  51 E 1581  PRO ALA ARG GLU ASP CYS ARG GLY LEU THR GLY PRO LEU          
SEQRES  52 E 1581  GLN SER LEU VAL PRO SER ALA ASP GLY ASP ALA ASP ASN          
SEQRES  53 E 1581  CYS CYS VAL GLN ILE MET GLY GLY TYR PHE THR TRP THR          
SEQRES  54 E 1581  PRO ASP GLY ILE PRO THR LEU SER ASN ILE THR ILE ARG          
SEQRES  55 E 1581  ILE PRO ARG GLY GLN LEU THR MET ILE VAL GLY GLN VAL          
SEQRES  56 E 1581  GLY CYS GLY LYS SER SER LEU LEU LEU ALA ALA LEU GLY          
SEQRES  57 E 1581  GLU MET GLN LYS VAL SER GLY ALA VAL PHE TRP SER SER          
SEQRES  58 E 1581  LEU PRO ASP SER GLU ILE GLY GLU ASP PRO SER PRO GLU          
SEQRES  59 E 1581  ARG GLU THR ALA THR ASP LEU ASP ILE ARG LYS ARG GLY          
SEQRES  60 E 1581  PRO VAL ALA TYR ALA SER GLN LYS PRO TRP LEU LEU ASN          
SEQRES  61 E 1581  ALA THR VAL GLU GLU ASN ILE ILE PHE GLU SER PRO PHE          
SEQRES  62 E 1581  ASN LYS GLN ARG TYR LYS MET VAL ILE GLU ALA CYS SER          
SEQRES  63 E 1581  LEU GLN PRO ASP ILE ASP ILE LEU PRO HIS GLY ASP GLN          
SEQRES  64 E 1581  THR GLN ILE GLY GLU ARG GLY ILE ASN LEU SER GLY GLY          
SEQRES  65 E 1581  GLN ARG GLN ARG ILE SER VAL ALA ARG ALA LEU TYR GLN          
SEQRES  66 E 1581  HIS ALA ASN VAL VAL PHE LEU ASP ASP PRO PHE SER ALA          
SEQRES  67 E 1581  LEU ASP ILE HIS LEU SER ASP HIS LEU MET GLN ALA GLY          
SEQRES  68 E 1581  ILE LEU GLU LEU LEU ARG ASP ASP LYS ARG THR VAL VAL          
SEQRES  69 E 1581  LEU VAL THR HIS LYS LEU GLN TYR LEU PRO HIS ALA ASP          
SEQRES  70 E 1581  TRP ILE ILE ALA MET LYS ASP GLY THR ILE GLN ARG GLU          
SEQRES  71 E 1581  GLY THR LEU LYS ASP PHE GLN ARG SER GLU CYS GLN LEU          
SEQRES  72 E 1581  PHE GLU HIS TRP LYS THR LEU MET ASN ARG GLN ASP GLN          
SEQRES  73 E 1581  GLU LEU GLU LYS GLU THR VAL THR GLU ARG LYS ALA THR          
SEQRES  74 E 1581  GLU PRO PRO GLN GLY LEU SER ARG ALA MET SER SER ARG          
SEQRES  75 E 1581  ASP GLY LEU LEU GLN ASP GLU GLU GLU GLU GLU GLU GLU          
SEQRES  76 E 1581  ALA ALA GLU SER GLU GLU ASP ASP ASN LEU SER SER MET          
SEQRES  77 E 1581  LEU HIS GLN ARG ALA GLU ILE PRO TRP ARG ALA CYS ALA          
SEQRES  78 E 1581  LYS TYR LEU SER SER ALA GLY ILE LEU LEU LEU SER LEU          
SEQRES  79 E 1581  LEU VAL PHE SER GLN LEU LEU LYS HIS MET VAL LEU VAL          
SEQRES  80 E 1581  ALA ILE ASP TYR TRP LEU ALA LYS TRP THR ASP SER ALA          
SEQRES  81 E 1581  LEU THR LEU THR PRO ALA ALA ARG ASN CYS SER LEU SER          
SEQRES  82 E 1581  GLN GLU CYS THR LEU ASP GLN THR VAL TYR ALA MET VAL          
SEQRES  83 E 1581  PHE THR VAL LEU CYS SER LEU GLY ILE VAL LEU CYS LEU          
SEQRES  84 E 1581  VAL THR SER VAL THR VAL GLU TRP THR GLY LEU LYS VAL          
SEQRES  85 E 1581  ALA LYS ARG LEU HIS ARG SER LEU LEU ASN ARG ILE ILE          
SEQRES  86 E 1581  LEU ALA PRO MET ARG PHE PHE GLU THR THR PRO LEU GLY          
SEQRES  87 E 1581  SER ILE LEU ASN ARG PHE SER SER ASP CYS ASN THR ILE          
SEQRES  88 E 1581  ASP GLN HIS ILE PRO SER THR LEU GLU CYS LEU SER ARG          
SEQRES  89 E 1581  SER THR LEU LEU CYS VAL SER ALA LEU ALA VAL ILE SER          
SEQRES  90 E 1581  TYR VAL THR PRO VAL PHE LEU VAL ALA LEU LEU PRO LEU          
SEQRES  91 E 1581  ALA ILE VAL CYS TYR PHE ILE GLN LYS TYR PHE ARG VAL          
SEQRES  92 E 1581  ALA SER ARG ASP LEU GLN GLN LEU ASP ASP THR THR GLN          
SEQRES  93 E 1581  LEU PRO LEU LEU SER HIS PHE ALA GLU THR VAL GLU GLY          
SEQRES  94 E 1581  LEU THR THR ILE ARG ALA PHE ARG TYR GLU ALA ARG PHE          
SEQRES  95 E 1581  GLN GLN LYS LEU LEU GLU TYR THR ASP SER ASN ASN ILE          
SEQRES  96 E 1581  ALA SER LEU PHE LEU THR ALA ALA ASN ARG TRP LEU GLU          
SEQRES  97 E 1581  VAL ARG MET GLU TYR ILE GLY ALA CYS VAL VAL LEU ILE          
SEQRES  98 E 1581  ALA ALA VAL THR SER ILE SER ASN SER LEU HIS ARG GLU          
SEQRES  99 E 1581  LEU SER ALA GLY LEU VAL GLY LEU GLY LEU THR TYR ALA          
SEQRES 100 E 1581  LEU MET VAL SER ASN TYR LEU ASN TRP MET VAL ARG ASN          
SEQRES 101 E 1581  LEU ALA ASP MET GLU LEU GLN LEU GLY ALA VAL LYS ARG          
SEQRES 102 E 1581  ILE HIS GLY LEU LEU LYS THR GLU ALA GLU SER TYR GLU          
SEQRES 103 E 1581  GLY LEU LEU ALA PRO SER LEU ILE PRO LYS ASN TRP PRO          
SEQRES 104 E 1581  ASP GLN GLY LYS ILE GLN ILE GLN ASN LEU SER VAL ARG          
SEQRES 105 E 1581  TYR ASP SER SER LEU LYS PRO VAL LEU LYS HIS VAL ASN          
SEQRES 106 E 1581  ALA LEU ILE ALA PRO GLY GLN LYS ILE GLY ILE CYS GLY          
SEQRES 107 E 1581  ARG THR GLY SER GLY LYS SER SER PHE SER LEU ALA PHE          
SEQRES 108 E 1581  PHE ARG MET VAL ASP THR PHE GLU GLY HIS ILE ILE ILE          
SEQRES 109 E 1581  ASP GLY ILE ASP ILE ALA LYS LEU PRO LEU HIS THR LEU          
SEQRES 110 E 1581  ARG SER ARG LEU SER ILE ILE LEU GLN ASP PRO VAL LEU          
SEQRES 111 E 1581  PHE SER GLY THR ILE ARG PHE ASN LEU ASP PRO GLU ARG          
SEQRES 112 E 1581  LYS CYS SER ASP SER THR LEU TRP GLU ALA LEU GLU ILE          
SEQRES 113 E 1581  ALA GLN LEU LYS LEU VAL VAL LYS ALA LEU PRO GLY GLY          
SEQRES 114 E 1581  LEU ASP ALA ILE ILE THR GLU GLY GLY GLU ASN PHE SER          
SEQRES 115 E 1581  GLN GLY GLN ARG GLN LEU PHE CYS LEU ALA ARG ALA PHE          
SEQRES 116 E 1581  VAL ARG LYS THR SER ILE PHE ILE MET ASP GLU ALA THR          
SEQRES 117 E 1581  ALA SER ILE ASP MET ALA THR GLU ASN ILE LEU GLN LYS          
SEQRES 118 E 1581  VAL VAL MET THR ALA PHE ALA ASP ARG THR VAL VAL THR          
SEQRES 119 E 1581  ILE ALA HIS ARG VAL HIS THR ILE LEU SER ALA ASP LEU          
SEQRES 120 E 1581  VAL ILE VAL LEU LYS ARG GLY ALA ILE LEU GLU PHE ASP          
SEQRES 121 E 1581  LYS PRO GLU LYS LEU LEU SER ARG LYS ASP SER VAL PHE          
SEQRES 122 E 1581  ALA SER PHE VAL ARG ALA ASP LYS                              
SEQRES   1 H 1581  MET PRO LEU ALA PHE CYS GLY SER GLU ASN HIS SER ALA          
SEQRES   2 H 1581  ALA TYR ARG VAL ASP GLN GLY VAL LEU ASN ASN GLY CYS          
SEQRES   3 H 1581  PHE VAL ASP ALA LEU ASN VAL VAL PRO HIS VAL PHE LEU          
SEQRES   4 H 1581  LEU PHE ILE THR PHE PRO ILE LEU PHE ILE GLY TRP GLY          
SEQRES   5 H 1581  SER GLN SER SER LYS VAL HIS ILE HIS HIS SER THR TRP          
SEQRES   6 H 1581  LEU HIS PHE PRO GLY HIS ASN LEU ARG TRP ILE LEU THR          
SEQRES   7 H 1581  PHE MET LEU LEU PHE VAL LEU VAL CYS GLU ILE ALA GLU          
SEQRES   8 H 1581  GLY ILE LEU SER ASP GLY VAL THR GLU SER HIS HIS LEU          
SEQRES   9 H 1581  HIS LEU TYR MET PRO ALA GLY MET ALA PHE MET ALA ALA          
SEQRES  10 H 1581  VAL THR SER VAL VAL TYR TYR HIS ASN ILE GLU THR SER          
SEQRES  11 H 1581  ASN PHE PRO LYS LEU LEU ILE ALA LEU LEU VAL TYR TRP          
SEQRES  12 H 1581  THR LEU ALA PHE ILE THR LYS THR ILE LYS PHE VAL LYS          
SEQRES  13 H 1581  PHE LEU ASP HIS ALA ILE GLY PHE SER GLN LEU ARG PHE          
SEQRES  14 H 1581  CYS LEU THR GLY LEU LEU VAL ILE LEU TYR GLY MET LEU          
SEQRES  15 H 1581  LEU LEU VAL GLU VAL ASN VAL ILE ARG VAL ARG ARG TYR          
SEQRES  16 H 1581  ILE PHE PHE LYS THR PRO ARG GLU VAL LYS PRO PRO GLU          
SEQRES  17 H 1581  ASP LEU GLN ASP LEU GLY VAL ARG PHE LEU GLN PRO PHE          
SEQRES  18 H 1581  VAL ASN LEU LEU SER LYS GLY THR TYR TRP TRP MET ASN          
SEQRES  19 H 1581  ALA PHE ILE LYS THR ALA HIS LYS LYS PRO ILE ASP LEU          
SEQRES  20 H 1581  ARG ALA ILE GLY LYS LEU PRO ILE ALA MET ARG ALA LEU          
SEQRES  21 H 1581  THR ASN TYR GLN ARG LEU CYS GLU ALA PHE ASP ALA GLN          
SEQRES  22 H 1581  VAL ARG LYS ASP ILE GLN GLY THR GLN GLY ALA ARG ALA          
SEQRES  23 H 1581  ILE TRP GLN ALA LEU SER HIS ALA PHE GLY ARG ARG LEU          
SEQRES  24 H 1581  VAL LEU SER SER THR PHE ARG ILE LEU ALA ASP LEU LEU          
SEQRES  25 H 1581  GLY PHE ALA GLY PRO LEU CYS ILE PHE GLY ILE VAL ASP          
SEQRES  26 H 1581  HIS LEU GLY LYS GLU ASN ASP VAL PHE GLN PRO LYS THR          
SEQRES  27 H 1581  GLN PHE LEU GLY VAL TYR PHE VAL SER SER GLN GLU PHE          
SEQRES  28 H 1581  LEU ALA ASN ALA TYR VAL LEU ALA VAL LEU LEU PHE LEU          
SEQRES  29 H 1581  ALA LEU LEU LEU GLN ARG THR PHE LEU GLN ALA SER TYR          
SEQRES  30 H 1581  TYR VAL ALA ILE GLU THR GLY ILE ASN LEU ARG GLY ALA          
SEQRES  31 H 1581  ILE GLN THR LYS ILE TYR ASN LYS ILE MET HIS LEU SER          
SEQRES  32 H 1581  THR SER ASN LEU SER MET GLY GLU MET THR ALA GLY GLN          
SEQRES  33 H 1581  ILE CYS ASN LEU VAL ALA ILE ASP THR ASN GLN LEU MET          
SEQRES  34 H 1581  TRP PHE PHE PHE LEU CYS PRO ASN LEU TRP ALA MET PRO          
SEQRES  35 H 1581  VAL GLN ILE ILE VAL GLY VAL ILE LEU LEU TYR TYR ILE          
SEQRES  36 H 1581  LEU GLY VAL SER ALA LEU ILE GLY ALA ALA VAL ILE ILE          
SEQRES  37 H 1581  LEU LEU ALA PRO VAL GLN TYR PHE VAL ALA THR LYS LEU          
SEQRES  38 H 1581  SER GLN ALA GLN ARG SER THR LEU GLU TYR SER ASN GLU          
SEQRES  39 H 1581  ARG LEU LYS GLN THR ASN GLU MET LEU ARG GLY ILE LYS          
SEQRES  40 H 1581  LEU LEU LYS LEU TYR ALA TRP GLU ASN ILE PHE ARG THR          
SEQRES  41 H 1581  ARG VAL GLU THR THR ARG ARG LYS GLU MET THR SER LEU          
SEQRES  42 H 1581  ARG ALA PHE ALA ILE TYR THR SER ILE SER ILE PHE MET          
SEQRES  43 H 1581  ASN THR ALA ILE PRO ILE ALA ALA VAL LEU ILE THR PHE          
SEQRES  44 H 1581  VAL GLY HIS VAL SER PHE PHE LYS GLU ALA ASP PHE SER          
SEQRES  45 H 1581  PRO SER VAL ALA PHE ALA SER LEU SER LEU PHE HIS ILE          
SEQRES  46 H 1581  LEU VAL THR PRO LEU PHE LEU LEU SER SER VAL VAL ARG          
SEQRES  47 H 1581  SER THR VAL LYS ALA LEU VAL SER VAL GLN LYS LEU SER          
SEQRES  48 H 1581  GLU PHE LEU SER SER ALA GLU ILE ARG GLU GLU GLN CYS          
SEQRES  49 H 1581  ALA PRO HIS GLU PRO THR PRO GLN GLY PRO ALA SER LYS          
SEQRES  50 H 1581  TYR GLN ALA VAL PRO LEU ARG VAL VAL ASN ARG LYS ARG          
SEQRES  51 H 1581  PRO ALA ARG GLU ASP CYS ARG GLY LEU THR GLY PRO LEU          
SEQRES  52 H 1581  GLN SER LEU VAL PRO SER ALA ASP GLY ASP ALA ASP ASN          
SEQRES  53 H 1581  CYS CYS VAL GLN ILE MET GLY GLY TYR PHE THR TRP THR          
SEQRES  54 H 1581  PRO ASP GLY ILE PRO THR LEU SER ASN ILE THR ILE ARG          
SEQRES  55 H 1581  ILE PRO ARG GLY GLN LEU THR MET ILE VAL GLY GLN VAL          
SEQRES  56 H 1581  GLY CYS GLY LYS SER SER LEU LEU LEU ALA ALA LEU GLY          
SEQRES  57 H 1581  GLU MET GLN LYS VAL SER GLY ALA VAL PHE TRP SER SER          
SEQRES  58 H 1581  LEU PRO ASP SER GLU ILE GLY GLU ASP PRO SER PRO GLU          
SEQRES  59 H 1581  ARG GLU THR ALA THR ASP LEU ASP ILE ARG LYS ARG GLY          
SEQRES  60 H 1581  PRO VAL ALA TYR ALA SER GLN LYS PRO TRP LEU LEU ASN          
SEQRES  61 H 1581  ALA THR VAL GLU GLU ASN ILE ILE PHE GLU SER PRO PHE          
SEQRES  62 H 1581  ASN LYS GLN ARG TYR LYS MET VAL ILE GLU ALA CYS SER          
SEQRES  63 H 1581  LEU GLN PRO ASP ILE ASP ILE LEU PRO HIS GLY ASP GLN          
SEQRES  64 H 1581  THR GLN ILE GLY GLU ARG GLY ILE ASN LEU SER GLY GLY          
SEQRES  65 H 1581  GLN ARG GLN ARG ILE SER VAL ALA ARG ALA LEU TYR GLN          
SEQRES  66 H 1581  HIS ALA ASN VAL VAL PHE LEU ASP ASP PRO PHE SER ALA          
SEQRES  67 H 1581  LEU ASP ILE HIS LEU SER ASP HIS LEU MET GLN ALA GLY          
SEQRES  68 H 1581  ILE LEU GLU LEU LEU ARG ASP ASP LYS ARG THR VAL VAL          
SEQRES  69 H 1581  LEU VAL THR HIS LYS LEU GLN TYR LEU PRO HIS ALA ASP          
SEQRES  70 H 1581  TRP ILE ILE ALA MET LYS ASP GLY THR ILE GLN ARG GLU          
SEQRES  71 H 1581  GLY THR LEU LYS ASP PHE GLN ARG SER GLU CYS GLN LEU          
SEQRES  72 H 1581  PHE GLU HIS TRP LYS THR LEU MET ASN ARG GLN ASP GLN          
SEQRES  73 H 1581  GLU LEU GLU LYS GLU THR VAL THR GLU ARG LYS ALA THR          
SEQRES  74 H 1581  GLU PRO PRO GLN GLY LEU SER ARG ALA MET SER SER ARG          
SEQRES  75 H 1581  ASP GLY LEU LEU GLN ASP GLU GLU GLU GLU GLU GLU GLU          
SEQRES  76 H 1581  ALA ALA GLU SER GLU GLU ASP ASP ASN LEU SER SER MET          
SEQRES  77 H 1581  LEU HIS GLN ARG ALA GLU ILE PRO TRP ARG ALA CYS ALA          
SEQRES  78 H 1581  LYS TYR LEU SER SER ALA GLY ILE LEU LEU LEU SER LEU          
SEQRES  79 H 1581  LEU VAL PHE SER GLN LEU LEU LYS HIS MET VAL LEU VAL          
SEQRES  80 H 1581  ALA ILE ASP TYR TRP LEU ALA LYS TRP THR ASP SER ALA          
SEQRES  81 H 1581  LEU THR LEU THR PRO ALA ALA ARG ASN CYS SER LEU SER          
SEQRES  82 H 1581  GLN GLU CYS THR LEU ASP GLN THR VAL TYR ALA MET VAL          
SEQRES  83 H 1581  PHE THR VAL LEU CYS SER LEU GLY ILE VAL LEU CYS LEU          
SEQRES  84 H 1581  VAL THR SER VAL THR VAL GLU TRP THR GLY LEU LYS VAL          
SEQRES  85 H 1581  ALA LYS ARG LEU HIS ARG SER LEU LEU ASN ARG ILE ILE          
SEQRES  86 H 1581  LEU ALA PRO MET ARG PHE PHE GLU THR THR PRO LEU GLY          
SEQRES  87 H 1581  SER ILE LEU ASN ARG PHE SER SER ASP CYS ASN THR ILE          
SEQRES  88 H 1581  ASP GLN HIS ILE PRO SER THR LEU GLU CYS LEU SER ARG          
SEQRES  89 H 1581  SER THR LEU LEU CYS VAL SER ALA LEU ALA VAL ILE SER          
SEQRES  90 H 1581  TYR VAL THR PRO VAL PHE LEU VAL ALA LEU LEU PRO LEU          
SEQRES  91 H 1581  ALA ILE VAL CYS TYR PHE ILE GLN LYS TYR PHE ARG VAL          
SEQRES  92 H 1581  ALA SER ARG ASP LEU GLN GLN LEU ASP ASP THR THR GLN          
SEQRES  93 H 1581  LEU PRO LEU LEU SER HIS PHE ALA GLU THR VAL GLU GLY          
SEQRES  94 H 1581  LEU THR THR ILE ARG ALA PHE ARG TYR GLU ALA ARG PHE          
SEQRES  95 H 1581  GLN GLN LYS LEU LEU GLU TYR THR ASP SER ASN ASN ILE          
SEQRES  96 H 1581  ALA SER LEU PHE LEU THR ALA ALA ASN ARG TRP LEU GLU          
SEQRES  97 H 1581  VAL ARG MET GLU TYR ILE GLY ALA CYS VAL VAL LEU ILE          
SEQRES  98 H 1581  ALA ALA VAL THR SER ILE SER ASN SER LEU HIS ARG GLU          
SEQRES  99 H 1581  LEU SER ALA GLY LEU VAL GLY LEU GLY LEU THR TYR ALA          
SEQRES 100 H 1581  LEU MET VAL SER ASN TYR LEU ASN TRP MET VAL ARG ASN          
SEQRES 101 H 1581  LEU ALA ASP MET GLU LEU GLN LEU GLY ALA VAL LYS ARG          
SEQRES 102 H 1581  ILE HIS GLY LEU LEU LYS THR GLU ALA GLU SER TYR GLU          
SEQRES 103 H 1581  GLY LEU LEU ALA PRO SER LEU ILE PRO LYS ASN TRP PRO          
SEQRES 104 H 1581  ASP GLN GLY LYS ILE GLN ILE GLN ASN LEU SER VAL ARG          
SEQRES 105 H 1581  TYR ASP SER SER LEU LYS PRO VAL LEU LYS HIS VAL ASN          
SEQRES 106 H 1581  ALA LEU ILE ALA PRO GLY GLN LYS ILE GLY ILE CYS GLY          
SEQRES 107 H 1581  ARG THR GLY SER GLY LYS SER SER PHE SER LEU ALA PHE          
SEQRES 108 H 1581  PHE ARG MET VAL ASP THR PHE GLU GLY HIS ILE ILE ILE          
SEQRES 109 H 1581  ASP GLY ILE ASP ILE ALA LYS LEU PRO LEU HIS THR LEU          
SEQRES 110 H 1581  ARG SER ARG LEU SER ILE ILE LEU GLN ASP PRO VAL LEU          
SEQRES 111 H 1581  PHE SER GLY THR ILE ARG PHE ASN LEU ASP PRO GLU ARG          
SEQRES 112 H 1581  LYS CYS SER ASP SER THR LEU TRP GLU ALA LEU GLU ILE          
SEQRES 113 H 1581  ALA GLN LEU LYS LEU VAL VAL LYS ALA LEU PRO GLY GLY          
SEQRES 114 H 1581  LEU ASP ALA ILE ILE THR GLU GLY GLY GLU ASN PHE SER          
SEQRES 115 H 1581  GLN GLY GLN ARG GLN LEU PHE CYS LEU ALA ARG ALA PHE          
SEQRES 116 H 1581  VAL ARG LYS THR SER ILE PHE ILE MET ASP GLU ALA THR          
SEQRES 117 H 1581  ALA SER ILE ASP MET ALA THR GLU ASN ILE LEU GLN LYS          
SEQRES 118 H 1581  VAL VAL MET THR ALA PHE ALA ASP ARG THR VAL VAL THR          
SEQRES 119 H 1581  ILE ALA HIS ARG VAL HIS THR ILE LEU SER ALA ASP LEU          
SEQRES 120 H 1581  VAL ILE VAL LEU LYS ARG GLY ALA ILE LEU GLU PHE ASP          
SEQRES 121 H 1581  LYS PRO GLU LYS LEU LEU SER ARG LYS ASP SER VAL PHE          
SEQRES 122 H 1581  ALA SER PHE VAL ARG ALA ASP LYS                              
SEQRES   1 G 1581  MET PRO LEU ALA PHE CYS GLY SER GLU ASN HIS SER ALA          
SEQRES   2 G 1581  ALA TYR ARG VAL ASP GLN GLY VAL LEU ASN ASN GLY CYS          
SEQRES   3 G 1581  PHE VAL ASP ALA LEU ASN VAL VAL PRO HIS VAL PHE LEU          
SEQRES   4 G 1581  LEU PHE ILE THR PHE PRO ILE LEU PHE ILE GLY TRP GLY          
SEQRES   5 G 1581  SER GLN SER SER LYS VAL HIS ILE HIS HIS SER THR TRP          
SEQRES   6 G 1581  LEU HIS PHE PRO GLY HIS ASN LEU ARG TRP ILE LEU THR          
SEQRES   7 G 1581  PHE MET LEU LEU PHE VAL LEU VAL CYS GLU ILE ALA GLU          
SEQRES   8 G 1581  GLY ILE LEU SER ASP GLY VAL THR GLU SER HIS HIS LEU          
SEQRES   9 G 1581  HIS LEU TYR MET PRO ALA GLY MET ALA PHE MET ALA ALA          
SEQRES  10 G 1581  VAL THR SER VAL VAL TYR TYR HIS ASN ILE GLU THR SER          
SEQRES  11 G 1581  ASN PHE PRO LYS LEU LEU ILE ALA LEU LEU VAL TYR TRP          
SEQRES  12 G 1581  THR LEU ALA PHE ILE THR LYS THR ILE LYS PHE VAL LYS          
SEQRES  13 G 1581  PHE LEU ASP HIS ALA ILE GLY PHE SER GLN LEU ARG PHE          
SEQRES  14 G 1581  CYS LEU THR GLY LEU LEU VAL ILE LEU TYR GLY MET LEU          
SEQRES  15 G 1581  LEU LEU VAL GLU VAL ASN VAL ILE ARG VAL ARG ARG TYR          
SEQRES  16 G 1581  ILE PHE PHE LYS THR PRO ARG GLU VAL LYS PRO PRO GLU          
SEQRES  17 G 1581  ASP LEU GLN ASP LEU GLY VAL ARG PHE LEU GLN PRO PHE          
SEQRES  18 G 1581  VAL ASN LEU LEU SER LYS GLY THR TYR TRP TRP MET ASN          
SEQRES  19 G 1581  ALA PHE ILE LYS THR ALA HIS LYS LYS PRO ILE ASP LEU          
SEQRES  20 G 1581  ARG ALA ILE GLY LYS LEU PRO ILE ALA MET ARG ALA LEU          
SEQRES  21 G 1581  THR ASN TYR GLN ARG LEU CYS GLU ALA PHE ASP ALA GLN          
SEQRES  22 G 1581  VAL ARG LYS ASP ILE GLN GLY THR GLN GLY ALA ARG ALA          
SEQRES  23 G 1581  ILE TRP GLN ALA LEU SER HIS ALA PHE GLY ARG ARG LEU          
SEQRES  24 G 1581  VAL LEU SER SER THR PHE ARG ILE LEU ALA ASP LEU LEU          
SEQRES  25 G 1581  GLY PHE ALA GLY PRO LEU CYS ILE PHE GLY ILE VAL ASP          
SEQRES  26 G 1581  HIS LEU GLY LYS GLU ASN ASP VAL PHE GLN PRO LYS THR          
SEQRES  27 G 1581  GLN PHE LEU GLY VAL TYR PHE VAL SER SER GLN GLU PHE          
SEQRES  28 G 1581  LEU ALA ASN ALA TYR VAL LEU ALA VAL LEU LEU PHE LEU          
SEQRES  29 G 1581  ALA LEU LEU LEU GLN ARG THR PHE LEU GLN ALA SER TYR          
SEQRES  30 G 1581  TYR VAL ALA ILE GLU THR GLY ILE ASN LEU ARG GLY ALA          
SEQRES  31 G 1581  ILE GLN THR LYS ILE TYR ASN LYS ILE MET HIS LEU SER          
SEQRES  32 G 1581  THR SER ASN LEU SER MET GLY GLU MET THR ALA GLY GLN          
SEQRES  33 G 1581  ILE CYS ASN LEU VAL ALA ILE ASP THR ASN GLN LEU MET          
SEQRES  34 G 1581  TRP PHE PHE PHE LEU CYS PRO ASN LEU TRP ALA MET PRO          
SEQRES  35 G 1581  VAL GLN ILE ILE VAL GLY VAL ILE LEU LEU TYR TYR ILE          
SEQRES  36 G 1581  LEU GLY VAL SER ALA LEU ILE GLY ALA ALA VAL ILE ILE          
SEQRES  37 G 1581  LEU LEU ALA PRO VAL GLN TYR PHE VAL ALA THR LYS LEU          
SEQRES  38 G 1581  SER GLN ALA GLN ARG SER THR LEU GLU TYR SER ASN GLU          
SEQRES  39 G 1581  ARG LEU LYS GLN THR ASN GLU MET LEU ARG GLY ILE LYS          
SEQRES  40 G 1581  LEU LEU LYS LEU TYR ALA TRP GLU ASN ILE PHE ARG THR          
SEQRES  41 G 1581  ARG VAL GLU THR THR ARG ARG LYS GLU MET THR SER LEU          
SEQRES  42 G 1581  ARG ALA PHE ALA ILE TYR THR SER ILE SER ILE PHE MET          
SEQRES  43 G 1581  ASN THR ALA ILE PRO ILE ALA ALA VAL LEU ILE THR PHE          
SEQRES  44 G 1581  VAL GLY HIS VAL SER PHE PHE LYS GLU ALA ASP PHE SER          
SEQRES  45 G 1581  PRO SER VAL ALA PHE ALA SER LEU SER LEU PHE HIS ILE          
SEQRES  46 G 1581  LEU VAL THR PRO LEU PHE LEU LEU SER SER VAL VAL ARG          
SEQRES  47 G 1581  SER THR VAL LYS ALA LEU VAL SER VAL GLN LYS LEU SER          
SEQRES  48 G 1581  GLU PHE LEU SER SER ALA GLU ILE ARG GLU GLU GLN CYS          
SEQRES  49 G 1581  ALA PRO HIS GLU PRO THR PRO GLN GLY PRO ALA SER LYS          
SEQRES  50 G 1581  TYR GLN ALA VAL PRO LEU ARG VAL VAL ASN ARG LYS ARG          
SEQRES  51 G 1581  PRO ALA ARG GLU ASP CYS ARG GLY LEU THR GLY PRO LEU          
SEQRES  52 G 1581  GLN SER LEU VAL PRO SER ALA ASP GLY ASP ALA ASP ASN          
SEQRES  53 G 1581  CYS CYS VAL GLN ILE MET GLY GLY TYR PHE THR TRP THR          
SEQRES  54 G 1581  PRO ASP GLY ILE PRO THR LEU SER ASN ILE THR ILE ARG          
SEQRES  55 G 1581  ILE PRO ARG GLY GLN LEU THR MET ILE VAL GLY GLN VAL          
SEQRES  56 G 1581  GLY CYS GLY LYS SER SER LEU LEU LEU ALA ALA LEU GLY          
SEQRES  57 G 1581  GLU MET GLN LYS VAL SER GLY ALA VAL PHE TRP SER SER          
SEQRES  58 G 1581  LEU PRO ASP SER GLU ILE GLY GLU ASP PRO SER PRO GLU          
SEQRES  59 G 1581  ARG GLU THR ALA THR ASP LEU ASP ILE ARG LYS ARG GLY          
SEQRES  60 G 1581  PRO VAL ALA TYR ALA SER GLN LYS PRO TRP LEU LEU ASN          
SEQRES  61 G 1581  ALA THR VAL GLU GLU ASN ILE ILE PHE GLU SER PRO PHE          
SEQRES  62 G 1581  ASN LYS GLN ARG TYR LYS MET VAL ILE GLU ALA CYS SER          
SEQRES  63 G 1581  LEU GLN PRO ASP ILE ASP ILE LEU PRO HIS GLY ASP GLN          
SEQRES  64 G 1581  THR GLN ILE GLY GLU ARG GLY ILE ASN LEU SER GLY GLY          
SEQRES  65 G 1581  GLN ARG GLN ARG ILE SER VAL ALA ARG ALA LEU TYR GLN          
SEQRES  66 G 1581  HIS ALA ASN VAL VAL PHE LEU ASP ASP PRO PHE SER ALA          
SEQRES  67 G 1581  LEU ASP ILE HIS LEU SER ASP HIS LEU MET GLN ALA GLY          
SEQRES  68 G 1581  ILE LEU GLU LEU LEU ARG ASP ASP LYS ARG THR VAL VAL          
SEQRES  69 G 1581  LEU VAL THR HIS LYS LEU GLN TYR LEU PRO HIS ALA ASP          
SEQRES  70 G 1581  TRP ILE ILE ALA MET LYS ASP GLY THR ILE GLN ARG GLU          
SEQRES  71 G 1581  GLY THR LEU LYS ASP PHE GLN ARG SER GLU CYS GLN LEU          
SEQRES  72 G 1581  PHE GLU HIS TRP LYS THR LEU MET ASN ARG GLN ASP GLN          
SEQRES  73 G 1581  GLU LEU GLU LYS GLU THR VAL THR GLU ARG LYS ALA THR          
SEQRES  74 G 1581  GLU PRO PRO GLN GLY LEU SER ARG ALA MET SER SER ARG          
SEQRES  75 G 1581  ASP GLY LEU LEU GLN ASP GLU GLU GLU GLU GLU GLU GLU          
SEQRES  76 G 1581  ALA ALA GLU SER GLU GLU ASP ASP ASN LEU SER SER MET          
SEQRES  77 G 1581  LEU HIS GLN ARG ALA GLU ILE PRO TRP ARG ALA CYS ALA          
SEQRES  78 G 1581  LYS TYR LEU SER SER ALA GLY ILE LEU LEU LEU SER LEU          
SEQRES  79 G 1581  LEU VAL PHE SER GLN LEU LEU LYS HIS MET VAL LEU VAL          
SEQRES  80 G 1581  ALA ILE ASP TYR TRP LEU ALA LYS TRP THR ASP SER ALA          
SEQRES  81 G 1581  LEU THR LEU THR PRO ALA ALA ARG ASN CYS SER LEU SER          
SEQRES  82 G 1581  GLN GLU CYS THR LEU ASP GLN THR VAL TYR ALA MET VAL          
SEQRES  83 G 1581  PHE THR VAL LEU CYS SER LEU GLY ILE VAL LEU CYS LEU          
SEQRES  84 G 1581  VAL THR SER VAL THR VAL GLU TRP THR GLY LEU LYS VAL          
SEQRES  85 G 1581  ALA LYS ARG LEU HIS ARG SER LEU LEU ASN ARG ILE ILE          
SEQRES  86 G 1581  LEU ALA PRO MET ARG PHE PHE GLU THR THR PRO LEU GLY          
SEQRES  87 G 1581  SER ILE LEU ASN ARG PHE SER SER ASP CYS ASN THR ILE          
SEQRES  88 G 1581  ASP GLN HIS ILE PRO SER THR LEU GLU CYS LEU SER ARG          
SEQRES  89 G 1581  SER THR LEU LEU CYS VAL SER ALA LEU ALA VAL ILE SER          
SEQRES  90 G 1581  TYR VAL THR PRO VAL PHE LEU VAL ALA LEU LEU PRO LEU          
SEQRES  91 G 1581  ALA ILE VAL CYS TYR PHE ILE GLN LYS TYR PHE ARG VAL          
SEQRES  92 G 1581  ALA SER ARG ASP LEU GLN GLN LEU ASP ASP THR THR GLN          
SEQRES  93 G 1581  LEU PRO LEU LEU SER HIS PHE ALA GLU THR VAL GLU GLY          
SEQRES  94 G 1581  LEU THR THR ILE ARG ALA PHE ARG TYR GLU ALA ARG PHE          
SEQRES  95 G 1581  GLN GLN LYS LEU LEU GLU TYR THR ASP SER ASN ASN ILE          
SEQRES  96 G 1581  ALA SER LEU PHE LEU THR ALA ALA ASN ARG TRP LEU GLU          
SEQRES  97 G 1581  VAL ARG MET GLU TYR ILE GLY ALA CYS VAL VAL LEU ILE          
SEQRES  98 G 1581  ALA ALA VAL THR SER ILE SER ASN SER LEU HIS ARG GLU          
SEQRES  99 G 1581  LEU SER ALA GLY LEU VAL GLY LEU GLY LEU THR TYR ALA          
SEQRES 100 G 1581  LEU MET VAL SER ASN TYR LEU ASN TRP MET VAL ARG ASN          
SEQRES 101 G 1581  LEU ALA ASP MET GLU LEU GLN LEU GLY ALA VAL LYS ARG          
SEQRES 102 G 1581  ILE HIS GLY LEU LEU LYS THR GLU ALA GLU SER TYR GLU          
SEQRES 103 G 1581  GLY LEU LEU ALA PRO SER LEU ILE PRO LYS ASN TRP PRO          
SEQRES 104 G 1581  ASP GLN GLY LYS ILE GLN ILE GLN ASN LEU SER VAL ARG          
SEQRES 105 G 1581  TYR ASP SER SER LEU LYS PRO VAL LEU LYS HIS VAL ASN          
SEQRES 106 G 1581  ALA LEU ILE ALA PRO GLY GLN LYS ILE GLY ILE CYS GLY          
SEQRES 107 G 1581  ARG THR GLY SER GLY LYS SER SER PHE SER LEU ALA PHE          
SEQRES 108 G 1581  PHE ARG MET VAL ASP THR PHE GLU GLY HIS ILE ILE ILE          
SEQRES 109 G 1581  ASP GLY ILE ASP ILE ALA LYS LEU PRO LEU HIS THR LEU          
SEQRES 110 G 1581  ARG SER ARG LEU SER ILE ILE LEU GLN ASP PRO VAL LEU          
SEQRES 111 G 1581  PHE SER GLY THR ILE ARG PHE ASN LEU ASP PRO GLU ARG          
SEQRES 112 G 1581  LYS CYS SER ASP SER THR LEU TRP GLU ALA LEU GLU ILE          
SEQRES 113 G 1581  ALA GLN LEU LYS LEU VAL VAL LYS ALA LEU PRO GLY GLY          
SEQRES 114 G 1581  LEU ASP ALA ILE ILE THR GLU GLY GLY GLU ASN PHE SER          
SEQRES 115 G 1581  GLN GLY GLN ARG GLN LEU PHE CYS LEU ALA ARG ALA PHE          
SEQRES 116 G 1581  VAL ARG LYS THR SER ILE PHE ILE MET ASP GLU ALA THR          
SEQRES 117 G 1581  ALA SER ILE ASP MET ALA THR GLU ASN ILE LEU GLN LYS          
SEQRES 118 G 1581  VAL VAL MET THR ALA PHE ALA ASP ARG THR VAL VAL THR          
SEQRES 119 G 1581  ILE ALA HIS ARG VAL HIS THR ILE LEU SER ALA ASP LEU          
SEQRES 120 G 1581  VAL ILE VAL LEU LYS ARG GLY ALA ILE LEU GLU PHE ASP          
SEQRES 121 G 1581  LYS PRO GLU LYS LEU LEU SER ARG LYS ASP SER VAL PHE          
SEQRES 122 G 1581  ALA SER PHE VAL ARG ALA ASP LYS                              
SEQRES   1 F 1581  MET PRO LEU ALA PHE CYS GLY SER GLU ASN HIS SER ALA          
SEQRES   2 F 1581  ALA TYR ARG VAL ASP GLN GLY VAL LEU ASN ASN GLY CYS          
SEQRES   3 F 1581  PHE VAL ASP ALA LEU ASN VAL VAL PRO HIS VAL PHE LEU          
SEQRES   4 F 1581  LEU PHE ILE THR PHE PRO ILE LEU PHE ILE GLY TRP GLY          
SEQRES   5 F 1581  SER GLN SER SER LYS VAL HIS ILE HIS HIS SER THR TRP          
SEQRES   6 F 1581  LEU HIS PHE PRO GLY HIS ASN LEU ARG TRP ILE LEU THR          
SEQRES   7 F 1581  PHE MET LEU LEU PHE VAL LEU VAL CYS GLU ILE ALA GLU          
SEQRES   8 F 1581  GLY ILE LEU SER ASP GLY VAL THR GLU SER HIS HIS LEU          
SEQRES   9 F 1581  HIS LEU TYR MET PRO ALA GLY MET ALA PHE MET ALA ALA          
SEQRES  10 F 1581  VAL THR SER VAL VAL TYR TYR HIS ASN ILE GLU THR SER          
SEQRES  11 F 1581  ASN PHE PRO LYS LEU LEU ILE ALA LEU LEU VAL TYR TRP          
SEQRES  12 F 1581  THR LEU ALA PHE ILE THR LYS THR ILE LYS PHE VAL LYS          
SEQRES  13 F 1581  PHE LEU ASP HIS ALA ILE GLY PHE SER GLN LEU ARG PHE          
SEQRES  14 F 1581  CYS LEU THR GLY LEU LEU VAL ILE LEU TYR GLY MET LEU          
SEQRES  15 F 1581  LEU LEU VAL GLU VAL ASN VAL ILE ARG VAL ARG ARG TYR          
SEQRES  16 F 1581  ILE PHE PHE LYS THR PRO ARG GLU VAL LYS PRO PRO GLU          
SEQRES  17 F 1581  ASP LEU GLN ASP LEU GLY VAL ARG PHE LEU GLN PRO PHE          
SEQRES  18 F 1581  VAL ASN LEU LEU SER LYS GLY THR TYR TRP TRP MET ASN          
SEQRES  19 F 1581  ALA PHE ILE LYS THR ALA HIS LYS LYS PRO ILE ASP LEU          
SEQRES  20 F 1581  ARG ALA ILE GLY LYS LEU PRO ILE ALA MET ARG ALA LEU          
SEQRES  21 F 1581  THR ASN TYR GLN ARG LEU CYS GLU ALA PHE ASP ALA GLN          
SEQRES  22 F 1581  VAL ARG LYS ASP ILE GLN GLY THR GLN GLY ALA ARG ALA          
SEQRES  23 F 1581  ILE TRP GLN ALA LEU SER HIS ALA PHE GLY ARG ARG LEU          
SEQRES  24 F 1581  VAL LEU SER SER THR PHE ARG ILE LEU ALA ASP LEU LEU          
SEQRES  25 F 1581  GLY PHE ALA GLY PRO LEU CYS ILE PHE GLY ILE VAL ASP          
SEQRES  26 F 1581  HIS LEU GLY LYS GLU ASN ASP VAL PHE GLN PRO LYS THR          
SEQRES  27 F 1581  GLN PHE LEU GLY VAL TYR PHE VAL SER SER GLN GLU PHE          
SEQRES  28 F 1581  LEU ALA ASN ALA TYR VAL LEU ALA VAL LEU LEU PHE LEU          
SEQRES  29 F 1581  ALA LEU LEU LEU GLN ARG THR PHE LEU GLN ALA SER TYR          
SEQRES  30 F 1581  TYR VAL ALA ILE GLU THR GLY ILE ASN LEU ARG GLY ALA          
SEQRES  31 F 1581  ILE GLN THR LYS ILE TYR ASN LYS ILE MET HIS LEU SER          
SEQRES  32 F 1581  THR SER ASN LEU SER MET GLY GLU MET THR ALA GLY GLN          
SEQRES  33 F 1581  ILE CYS ASN LEU VAL ALA ILE ASP THR ASN GLN LEU MET          
SEQRES  34 F 1581  TRP PHE PHE PHE LEU CYS PRO ASN LEU TRP ALA MET PRO          
SEQRES  35 F 1581  VAL GLN ILE ILE VAL GLY VAL ILE LEU LEU TYR TYR ILE          
SEQRES  36 F 1581  LEU GLY VAL SER ALA LEU ILE GLY ALA ALA VAL ILE ILE          
SEQRES  37 F 1581  LEU LEU ALA PRO VAL GLN TYR PHE VAL ALA THR LYS LEU          
SEQRES  38 F 1581  SER GLN ALA GLN ARG SER THR LEU GLU TYR SER ASN GLU          
SEQRES  39 F 1581  ARG LEU LYS GLN THR ASN GLU MET LEU ARG GLY ILE LYS          
SEQRES  40 F 1581  LEU LEU LYS LEU TYR ALA TRP GLU ASN ILE PHE ARG THR          
SEQRES  41 F 1581  ARG VAL GLU THR THR ARG ARG LYS GLU MET THR SER LEU          
SEQRES  42 F 1581  ARG ALA PHE ALA ILE TYR THR SER ILE SER ILE PHE MET          
SEQRES  43 F 1581  ASN THR ALA ILE PRO ILE ALA ALA VAL LEU ILE THR PHE          
SEQRES  44 F 1581  VAL GLY HIS VAL SER PHE PHE LYS GLU ALA ASP PHE SER          
SEQRES  45 F 1581  PRO SER VAL ALA PHE ALA SER LEU SER LEU PHE HIS ILE          
SEQRES  46 F 1581  LEU VAL THR PRO LEU PHE LEU LEU SER SER VAL VAL ARG          
SEQRES  47 F 1581  SER THR VAL LYS ALA LEU VAL SER VAL GLN LYS LEU SER          
SEQRES  48 F 1581  GLU PHE LEU SER SER ALA GLU ILE ARG GLU GLU GLN CYS          
SEQRES  49 F 1581  ALA PRO HIS GLU PRO THR PRO GLN GLY PRO ALA SER LYS          
SEQRES  50 F 1581  TYR GLN ALA VAL PRO LEU ARG VAL VAL ASN ARG LYS ARG          
SEQRES  51 F 1581  PRO ALA ARG GLU ASP CYS ARG GLY LEU THR GLY PRO LEU          
SEQRES  52 F 1581  GLN SER LEU VAL PRO SER ALA ASP GLY ASP ALA ASP ASN          
SEQRES  53 F 1581  CYS CYS VAL GLN ILE MET GLY GLY TYR PHE THR TRP THR          
SEQRES  54 F 1581  PRO ASP GLY ILE PRO THR LEU SER ASN ILE THR ILE ARG          
SEQRES  55 F 1581  ILE PRO ARG GLY GLN LEU THR MET ILE VAL GLY GLN VAL          
SEQRES  56 F 1581  GLY CYS GLY LYS SER SER LEU LEU LEU ALA ALA LEU GLY          
SEQRES  57 F 1581  GLU MET GLN LYS VAL SER GLY ALA VAL PHE TRP SER SER          
SEQRES  58 F 1581  LEU PRO ASP SER GLU ILE GLY GLU ASP PRO SER PRO GLU          
SEQRES  59 F 1581  ARG GLU THR ALA THR ASP LEU ASP ILE ARG LYS ARG GLY          
SEQRES  60 F 1581  PRO VAL ALA TYR ALA SER GLN LYS PRO TRP LEU LEU ASN          
SEQRES  61 F 1581  ALA THR VAL GLU GLU ASN ILE ILE PHE GLU SER PRO PHE          
SEQRES  62 F 1581  ASN LYS GLN ARG TYR LYS MET VAL ILE GLU ALA CYS SER          
SEQRES  63 F 1581  LEU GLN PRO ASP ILE ASP ILE LEU PRO HIS GLY ASP GLN          
SEQRES  64 F 1581  THR GLN ILE GLY GLU ARG GLY ILE ASN LEU SER GLY GLY          
SEQRES  65 F 1581  GLN ARG GLN ARG ILE SER VAL ALA ARG ALA LEU TYR GLN          
SEQRES  66 F 1581  HIS ALA ASN VAL VAL PHE LEU ASP ASP PRO PHE SER ALA          
SEQRES  67 F 1581  LEU ASP ILE HIS LEU SER ASP HIS LEU MET GLN ALA GLY          
SEQRES  68 F 1581  ILE LEU GLU LEU LEU ARG ASP ASP LYS ARG THR VAL VAL          
SEQRES  69 F 1581  LEU VAL THR HIS LYS LEU GLN TYR LEU PRO HIS ALA ASP          
SEQRES  70 F 1581  TRP ILE ILE ALA MET LYS ASP GLY THR ILE GLN ARG GLU          
SEQRES  71 F 1581  GLY THR LEU LYS ASP PHE GLN ARG SER GLU CYS GLN LEU          
SEQRES  72 F 1581  PHE GLU HIS TRP LYS THR LEU MET ASN ARG GLN ASP GLN          
SEQRES  73 F 1581  GLU LEU GLU LYS GLU THR VAL THR GLU ARG LYS ALA THR          
SEQRES  74 F 1581  GLU PRO PRO GLN GLY LEU SER ARG ALA MET SER SER ARG          
SEQRES  75 F 1581  ASP GLY LEU LEU GLN ASP GLU GLU GLU GLU GLU GLU GLU          
SEQRES  76 F 1581  ALA ALA GLU SER GLU GLU ASP ASP ASN LEU SER SER MET          
SEQRES  77 F 1581  LEU HIS GLN ARG ALA GLU ILE PRO TRP ARG ALA CYS ALA          
SEQRES  78 F 1581  LYS TYR LEU SER SER ALA GLY ILE LEU LEU LEU SER LEU          
SEQRES  79 F 1581  LEU VAL PHE SER GLN LEU LEU LYS HIS MET VAL LEU VAL          
SEQRES  80 F 1581  ALA ILE ASP TYR TRP LEU ALA LYS TRP THR ASP SER ALA          
SEQRES  81 F 1581  LEU THR LEU THR PRO ALA ALA ARG ASN CYS SER LEU SER          
SEQRES  82 F 1581  GLN GLU CYS THR LEU ASP GLN THR VAL TYR ALA MET VAL          
SEQRES  83 F 1581  PHE THR VAL LEU CYS SER LEU GLY ILE VAL LEU CYS LEU          
SEQRES  84 F 1581  VAL THR SER VAL THR VAL GLU TRP THR GLY LEU LYS VAL          
SEQRES  85 F 1581  ALA LYS ARG LEU HIS ARG SER LEU LEU ASN ARG ILE ILE          
SEQRES  86 F 1581  LEU ALA PRO MET ARG PHE PHE GLU THR THR PRO LEU GLY          
SEQRES  87 F 1581  SER ILE LEU ASN ARG PHE SER SER ASP CYS ASN THR ILE          
SEQRES  88 F 1581  ASP GLN HIS ILE PRO SER THR LEU GLU CYS LEU SER ARG          
SEQRES  89 F 1581  SER THR LEU LEU CYS VAL SER ALA LEU ALA VAL ILE SER          
SEQRES  90 F 1581  TYR VAL THR PRO VAL PHE LEU VAL ALA LEU LEU PRO LEU          
SEQRES  91 F 1581  ALA ILE VAL CYS TYR PHE ILE GLN LYS TYR PHE ARG VAL          
SEQRES  92 F 1581  ALA SER ARG ASP LEU GLN GLN LEU ASP ASP THR THR GLN          
SEQRES  93 F 1581  LEU PRO LEU LEU SER HIS PHE ALA GLU THR VAL GLU GLY          
SEQRES  94 F 1581  LEU THR THR ILE ARG ALA PHE ARG TYR GLU ALA ARG PHE          
SEQRES  95 F 1581  GLN GLN LYS LEU LEU GLU TYR THR ASP SER ASN ASN ILE          
SEQRES  96 F 1581  ALA SER LEU PHE LEU THR ALA ALA ASN ARG TRP LEU GLU          
SEQRES  97 F 1581  VAL ARG MET GLU TYR ILE GLY ALA CYS VAL VAL LEU ILE          
SEQRES  98 F 1581  ALA ALA VAL THR SER ILE SER ASN SER LEU HIS ARG GLU          
SEQRES  99 F 1581  LEU SER ALA GLY LEU VAL GLY LEU GLY LEU THR TYR ALA          
SEQRES 100 F 1581  LEU MET VAL SER ASN TYR LEU ASN TRP MET VAL ARG ASN          
SEQRES 101 F 1581  LEU ALA ASP MET GLU LEU GLN LEU GLY ALA VAL LYS ARG          
SEQRES 102 F 1581  ILE HIS GLY LEU LEU LYS THR GLU ALA GLU SER TYR GLU          
SEQRES 103 F 1581  GLY LEU LEU ALA PRO SER LEU ILE PRO LYS ASN TRP PRO          
SEQRES 104 F 1581  ASP GLN GLY LYS ILE GLN ILE GLN ASN LEU SER VAL ARG          
SEQRES 105 F 1581  TYR ASP SER SER LEU LYS PRO VAL LEU LYS HIS VAL ASN          
SEQRES 106 F 1581  ALA LEU ILE ALA PRO GLY GLN LYS ILE GLY ILE CYS GLY          
SEQRES 107 F 1581  ARG THR GLY SER GLY LYS SER SER PHE SER LEU ALA PHE          
SEQRES 108 F 1581  PHE ARG MET VAL ASP THR PHE GLU GLY HIS ILE ILE ILE          
SEQRES 109 F 1581  ASP GLY ILE ASP ILE ALA LYS LEU PRO LEU HIS THR LEU          
SEQRES 110 F 1581  ARG SER ARG LEU SER ILE ILE LEU GLN ASP PRO VAL LEU          
SEQRES 111 F 1581  PHE SER GLY THR ILE ARG PHE ASN LEU ASP PRO GLU ARG          
SEQRES 112 F 1581  LYS CYS SER ASP SER THR LEU TRP GLU ALA LEU GLU ILE          
SEQRES 113 F 1581  ALA GLN LEU LYS LEU VAL VAL LYS ALA LEU PRO GLY GLY          
SEQRES 114 F 1581  LEU ASP ALA ILE ILE THR GLU GLY GLY GLU ASN PHE SER          
SEQRES 115 F 1581  GLN GLY GLN ARG GLN LEU PHE CYS LEU ALA ARG ALA PHE          
SEQRES 116 F 1581  VAL ARG LYS THR SER ILE PHE ILE MET ASP GLU ALA THR          
SEQRES 117 F 1581  ALA SER ILE ASP MET ALA THR GLU ASN ILE LEU GLN LYS          
SEQRES 118 F 1581  VAL VAL MET THR ALA PHE ALA ASP ARG THR VAL VAL THR          
SEQRES 119 F 1581  ILE ALA HIS ARG VAL HIS THR ILE LEU SER ALA ASP LEU          
SEQRES 120 F 1581  VAL ILE VAL LEU LYS ARG GLY ALA ILE LEU GLU PHE ASP          
SEQRES 121 F 1581  LYS PRO GLU LYS LEU LEU SER ARG LYS ASP SER VAL PHE          
SEQRES 122 F 1581  ALA SER PHE VAL ARG ALA ASP LYS                              
HET    ATP  A 501      31                                                       
HET      K  A 502       1                                                       
HET      K  A 503       1                                                       
HET      K  A 504       1                                                       
HET    ATP  C 501      31                                                       
HET    ATP  B 501      31                                                       
HET    ATP  D 501      31                                                       
HET    ADP  E2001      27                                                       
HET     MG  E2002       1                                                       
HET     MG  E2003       1                                                       
HET    ATP  E2004      31                                                       
HET    ADP  H2001      27                                                       
HET     MG  H2002       1                                                       
HET     MG  H2003       1                                                       
HET    ATP  H2004      31                                                       
HET    ADP  G2001      27                                                       
HET     MG  G2002       1                                                       
HET     MG  G2003       1                                                       
HET    ATP  G2004      31                                                       
HET    ADP  F2001      27                                                       
HET     MG  F2002       1                                                       
HET     MG  F2003       1                                                       
HET    ATP  F2004      31                                                       
HETNAM     ATP ADENOSINE-5'-TRIPHOSPHATE                                        
HETNAM       K POTASSIUM ION                                                    
HETNAM     ADP ADENOSINE-5'-DIPHOSPHATE                                         
HETNAM      MG MAGNESIUM ION                                                    
FORMUL   9  ATP    8(C10 H16 N5 O13 P3)                                         
FORMUL  10    K    3(K 1+)                                                      
FORMUL  16  ADP    4(C10 H15 N5 O10 P2)                                         
FORMUL  17   MG    8(MG 2+)                                                     
HELIX    1 AA1 LEU A   56  ASP A   65  1                                  10    
HELIX    2 AA2 LYS A   67  HIS A   97  1                                  31    
HELIX    3 AA3 SER A  116  VAL A  129  1                                  14    
HELIX    4 AA4 CYS A  142  ALA A  172  1                                  31    
HELIX    5 AA5 SER A  265  LEU A  270  5                                   6    
HELIX    6 AA6 THR A  345  ALA A  358  1                                  14    
HELIX    7 AA7 LEU C   56  ASP C   65  1                                  10    
HELIX    8 AA8 LYS C   67  HIS C   97  1                                  31    
HELIX    9 AA9 SER C  116  VAL C  129  1                                  14    
HELIX   10 AB1 CYS C  142  ALA C  172  1                                  31    
HELIX   11 AB2 SER C  265  LEU C  270  5                                   6    
HELIX   12 AB3 THR C  345  ALA C  358  1                                  14    
HELIX   13 AB4 LEU B   56  ASP B   65  1                                  10    
HELIX   14 AB5 LYS B   67  HIS B   97  1                                  31    
HELIX   15 AB6 SER B  116  VAL B  129  1                                  14    
HELIX   16 AB7 CYS B  142  ALA B  172  1                                  31    
HELIX   17 AB8 SER B  265  LEU B  270  5                                   6    
HELIX   18 AB9 THR B  345  ALA B  358  1                                  14    
HELIX   19 AC1 LEU D   56  ASP D   65  1                                  10    
HELIX   20 AC2 LYS D   67  HIS D   97  1                                  31    
HELIX   21 AC3 SER D  116  VAL D  129  1                                  14    
HELIX   22 AC4 CYS D  142  ALA D  172  1                                  31    
HELIX   23 AC5 SER D  265  LEU D  270  5                                   6    
HELIX   24 AC6 THR D  345  ALA D  358  1                                  14    
HELIX   25 AC7 GLY E   20  ASN E   23  5                                   4    
HELIX   26 AC8 ASN E   24  ASN E   32  1                                   9    
HELIX   27 AC9 ASN E   32  PHE E   44  1                                  13    
HELIX   28 AD1 PHE E   44  GLY E   52  1                                   9    
HELIX   29 AD2 GLY E   70  SER E   95  1                                  26    
HELIX   30 AD3 HIS E  103  LEU E  106  5                                   4    
HELIX   31 AD4 TYR E  107  GLU E  128  1                                  22    
HELIX   32 AD5 LEU E  136  HIS E  160  1                                  25    
HELIX   33 AD6 SER E  165  ARG E  191  1                                  27    
HELIX   34 AD7 TYR E  263  ASP E  277  1                                  15    
HELIX   35 AD8 ILE E  287  ALA E  315  1                                  29    
HELIX   36 AD9 GLY E  316  GLY E  328  1                                  13    
HELIX   37 AE1 ASN E  354  LEU E  402  1                                  49    
HELIX   38 AE2 SER E  403  MET E  409  1                                   7    
HELIX   39 AE3 THR E  413  ILE E  455  1                                  43    
HELIX   40 AE4 GLY E  463  GLY E  505  1                                  43    
HELIX   41 AE5 ILE E  506  TYR E  512  1                                   7    
HELIX   42 AE6 TRP E  514  GLY E  561  1                                  48    
HELIX   43 AE7 SER E  574  LEU E  614  1                                  41    
HELIX   44 AE8 SER E  720  ALA E  726  1                                   7    
HELIX   45 AE9 THR E  782  PHE E  789  1                                   8    
HELIX   46 AF1 ASN E  794  SER E  806  1                                  13    
HELIX   47 AF2 LEU E  807  ILE E  813  1                                   7    
HELIX   48 AF3 HIS E  816  THR E  820  5                                   5    
HELIX   49 AF4 SER E  830  GLN E  845  1                                  16    
HELIX   50 AF5 ASP E  860  ASP E  878  1                                  19    
HELIX   51 AF6 LYS E  889  LEU E  893  5                                   5    
HELIX   52 AF7 SER E  919  TRP E  927  1                                   9    
HELIX   53 AF8 LYS E  928  LEU E  930  5                                   3    
HELIX   54 AF9 ILE E  995  SER E 1006  1                                  12    
HELIX   55 AG1 ILE E 1009  TRP E 1036  1                                  28    
HELIX   56 AG2 VAL E 1062  ILE E 1105  1                                  44    
HELIX   57 AG3 PRO E 1108  THR E 1115  1                                   8    
HELIX   58 AG4 PRO E 1116  SER E 1126  1                                  11    
HELIX   59 AG5 SER E 1126  THR E 1160  1                                  35    
HELIX   60 AG6 PHE E 1163  GLU E 1208  1                                  46    
HELIX   61 AG7 GLY E 1209  ARG E 1217  1                                   9    
HELIX   62 AG8 TYR E 1218  ARG E 1273  1                                  56    
HELIX   63 AG9 ALA E 1277  LYS E 1319  1                                  43    
HELIX   64 AH1 GLY E 1383  ALA E 1390  1                                   8    
HELIX   65 AH2 PHE E 1391  ARG E 1393  5                                   3    
HELIX   66 AH3 PRO E 1413  ARG E 1420  1                                   8    
HELIX   67 AH4 ILE E 1435  ASP E 1440  1                                   6    
HELIX   68 AH5 SER E 1446  ILE E 1456  1                                  11    
HELIX   69 AH6 LEU E 1459  ALA E 1465  1                                   7    
HELIX   70 AH7 THR E 1475  GLU E 1479  5                                   5    
HELIX   71 AH8 SER E 1482  VAL E 1496  1                                  15    
HELIX   72 AH9 ASP E 1512  PHE E 1527  1                                  16    
HELIX   73 AI1 THR E 1541  ALA E 1545  5                                   5    
HELIX   74 AI2 LYS E 1561  LYS E 1569  1                                   9    
HELIX   75 AI3 SER E 1571  LYS E 1581  1                                  11    
HELIX   76 AI4 GLY H   20  ASN H   23  5                                   4    
HELIX   77 AI5 ASN H   24  ASN H   32  1                                   9    
HELIX   78 AI6 ASN H   32  PHE H   44  1                                  13    
HELIX   79 AI7 PHE H   44  GLY H   52  1                                   9    
HELIX   80 AI8 GLY H   70  SER H   95  1                                  26    
HELIX   81 AI9 HIS H  103  LEU H  106  5                                   4    
HELIX   82 AJ1 TYR H  107  GLU H  128  1                                  22    
HELIX   83 AJ2 LEU H  136  HIS H  160  1                                  25    
HELIX   84 AJ3 SER H  165  ARG H  191  1                                  27    
HELIX   85 AJ4 TYR H  263  ASP H  277  1                                  15    
HELIX   86 AJ5 ILE H  287  ALA H  315  1                                  29    
HELIX   87 AJ6 GLY H  316  GLY H  328  1                                  13    
HELIX   88 AJ7 ASN H  354  LEU H  402  1                                  49    
HELIX   89 AJ8 SER H  403  MET H  409  1                                   7    
HELIX   90 AJ9 THR H  413  ILE H  455  1                                  43    
HELIX   91 AK1 GLY H  463  GLY H  505  1                                  43    
HELIX   92 AK2 ILE H  506  TYR H  512  1                                   7    
HELIX   93 AK3 TRP H  514  GLY H  561  1                                  48    
HELIX   94 AK4 SER H  574  LEU H  614  1                                  41    
HELIX   95 AK5 SER H  720  ALA H  726  1                                   7    
HELIX   96 AK6 THR H  782  PHE H  789  1                                   8    
HELIX   97 AK7 ASN H  794  SER H  806  1                                  13    
HELIX   98 AK8 LEU H  807  ILE H  813  1                                   7    
HELIX   99 AK9 HIS H  816  THR H  820  5                                   5    
HELIX  100 AL1 SER H  830  GLN H  845  1                                  16    
HELIX  101 AL2 ASP H  860  ASP H  878  1                                  19    
HELIX  102 AL3 LYS H  889  LEU H  893  5                                   5    
HELIX  103 AL4 SER H  919  TRP H  927  1                                   9    
HELIX  104 AL5 LYS H  928  LEU H  930  5                                   3    
HELIX  105 AL6 ILE H  995  SER H 1006  1                                  12    
HELIX  106 AL7 ILE H 1009  TRP H 1036  1                                  28    
HELIX  107 AL8 VAL H 1062  ILE H 1105  1                                  44    
HELIX  108 AL9 PRO H 1108  THR H 1115  1                                   8    
HELIX  109 AM1 PRO H 1116  SER H 1126  1                                  11    
HELIX  110 AM2 SER H 1126  THR H 1160  1                                  35    
HELIX  111 AM3 PHE H 1163  GLU H 1208  1                                  46    
HELIX  112 AM4 GLY H 1209  ARG H 1217  1                                   9    
HELIX  113 AM5 TYR H 1218  ARG H 1273  1                                  56    
HELIX  114 AM6 ALA H 1277  LYS H 1319  1                                  43    
HELIX  115 AM7 GLY H 1383  ALA H 1390  1                                   8    
HELIX  116 AM8 PHE H 1391  ARG H 1393  5                                   3    
HELIX  117 AM9 PRO H 1413  ARG H 1420  1                                   8    
HELIX  118 AN1 ILE H 1435  ASP H 1440  1                                   6    
HELIX  119 AN2 SER H 1446  ILE H 1456  1                                  11    
HELIX  120 AN3 LEU H 1459  ALA H 1465  1                                   7    
HELIX  121 AN4 THR H 1475  GLU H 1479  5                                   5    
HELIX  122 AN5 SER H 1482  VAL H 1496  1                                  15    
HELIX  123 AN6 ASP H 1512  PHE H 1527  1                                  16    
HELIX  124 AN7 THR H 1541  ALA H 1545  5                                   5    
HELIX  125 AN8 LYS H 1561  LYS H 1569  1                                   9    
HELIX  126 AN9 SER H 1571  LYS H 1581  1                                  11    
HELIX  127 AO1 GLY G   20  ASN G   23  5                                   4    
HELIX  128 AO2 ASN G   24  ASN G   32  1                                   9    
HELIX  129 AO3 ASN G   32  PHE G   44  1                                  13    
HELIX  130 AO4 PHE G   44  GLY G   52  1                                   9    
HELIX  131 AO5 GLY G   70  SER G   95  1                                  26    
HELIX  132 AO6 HIS G  103  LEU G  106  5                                   4    
HELIX  133 AO7 TYR G  107  GLU G  128  1                                  22    
HELIX  134 AO8 LEU G  136  HIS G  160  1                                  25    
HELIX  135 AO9 SER G  165  ARG G  191  1                                  27    
HELIX  136 AP1 TYR G  263  ASP G  277  1                                  15    
HELIX  137 AP2 ILE G  287  ALA G  315  1                                  29    
HELIX  138 AP3 GLY G  316  GLY G  328  1                                  13    
HELIX  139 AP4 ASN G  354  LEU G  402  1                                  49    
HELIX  140 AP5 SER G  403  MET G  409  1                                   7    
HELIX  141 AP6 THR G  413  ILE G  455  1                                  43    
HELIX  142 AP7 GLY G  463  GLY G  505  1                                  43    
HELIX  143 AP8 ILE G  506  TYR G  512  1                                   7    
HELIX  144 AP9 TRP G  514  GLY G  561  1                                  48    
HELIX  145 AQ1 SER G  574  LEU G  614  1                                  41    
HELIX  146 AQ2 SER G  720  ALA G  726  1                                   7    
HELIX  147 AQ3 THR G  782  PHE G  789  1                                   8    
HELIX  148 AQ4 ASN G  794  SER G  806  1                                  13    
HELIX  149 AQ5 LEU G  807  ILE G  813  1                                   7    
HELIX  150 AQ6 HIS G  816  THR G  820  5                                   5    
HELIX  151 AQ7 SER G  830  GLN G  845  1                                  16    
HELIX  152 AQ8 ASP G  860  ASP G  878  1                                  19    
HELIX  153 AQ9 LYS G  889  LEU G  893  5                                   5    
HELIX  154 AR1 SER G  919  TRP G  927  1                                   9    
HELIX  155 AR2 LYS G  928  LEU G  930  5                                   3    
HELIX  156 AR3 ILE G  995  SER G 1006  1                                  12    
HELIX  157 AR4 ILE G 1009  TRP G 1036  1                                  28    
HELIX  158 AR5 VAL G 1062  ILE G 1105  1                                  44    
HELIX  159 AR6 PRO G 1108  THR G 1115  1                                   8    
HELIX  160 AR7 PRO G 1116  SER G 1126  1                                  11    
HELIX  161 AR8 SER G 1126  THR G 1160  1                                  35    
HELIX  162 AR9 PHE G 1163  GLU G 1208  1                                  46    
HELIX  163 AS1 GLY G 1209  ARG G 1217  1                                   9    
HELIX  164 AS2 TYR G 1218  ARG G 1273  1                                  56    
HELIX  165 AS3 ALA G 1277  LYS G 1319  1                                  43    
HELIX  166 AS4 GLY G 1383  ALA G 1390  1                                   8    
HELIX  167 AS5 PHE G 1391  ARG G 1393  5                                   3    
HELIX  168 AS6 PRO G 1413  ARG G 1420  1                                   8    
HELIX  169 AS7 ILE G 1435  ASP G 1440  1                                   6    
HELIX  170 AS8 SER G 1446  ILE G 1456  1                                  11    
HELIX  171 AS9 LEU G 1459  ALA G 1465  1                                   7    
HELIX  172 AT1 THR G 1475  GLU G 1479  5                                   5    
HELIX  173 AT2 SER G 1482  VAL G 1496  1                                  15    
HELIX  174 AT3 ASP G 1512  PHE G 1527  1                                  16    
HELIX  175 AT4 THR G 1541  ALA G 1545  5                                   5    
HELIX  176 AT5 LYS G 1561  LYS G 1569  1                                   9    
HELIX  177 AT6 SER G 1571  LYS G 1581  1                                  11    
HELIX  178 AT7 GLY F   20  ASN F   23  5                                   4    
HELIX  179 AT8 ASN F   24  ASN F   32  1                                   9    
HELIX  180 AT9 ASN F   32  PHE F   44  1                                  13    
HELIX  181 AU1 PHE F   44  GLY F   52  1                                   9    
HELIX  182 AU2 GLY F   70  SER F   95  1                                  26    
HELIX  183 AU3 HIS F  103  LEU F  106  5                                   4    
HELIX  184 AU4 TYR F  107  GLU F  128  1                                  22    
HELIX  185 AU5 LEU F  136  HIS F  160  1                                  25    
HELIX  186 AU6 SER F  165  ARG F  191  1                                  27    
HELIX  187 AU7 TYR F  263  ASP F  277  1                                  15    
HELIX  188 AU8 ILE F  287  ALA F  315  1                                  29    
HELIX  189 AU9 GLY F  316  GLY F  328  1                                  13    
HELIX  190 AV1 ASN F  354  LEU F  402  1                                  49    
HELIX  191 AV2 SER F  403  MET F  409  1                                   7    
HELIX  192 AV3 THR F  413  ILE F  455  1                                  43    
HELIX  193 AV4 GLY F  463  GLY F  505  1                                  43    
HELIX  194 AV5 ILE F  506  TYR F  512  1                                   7    
HELIX  195 AV6 TRP F  514  GLY F  561  1                                  48    
HELIX  196 AV7 SER F  574  LEU F  614  1                                  41    
HELIX  197 AV8 SER F  720  ALA F  726  1                                   7    
HELIX  198 AV9 THR F  782  PHE F  789  1                                   8    
HELIX  199 AW1 ASN F  794  SER F  806  1                                  13    
HELIX  200 AW2 LEU F  807  ILE F  813  1                                   7    
HELIX  201 AW3 HIS F  816  THR F  820  5                                   5    
HELIX  202 AW4 SER F  830  GLN F  845  1                                  16    
HELIX  203 AW5 ASP F  860  ASP F  878  1                                  19    
HELIX  204 AW6 LYS F  889  LEU F  893  5                                   5    
HELIX  205 AW7 SER F  919  TRP F  927  1                                   9    
HELIX  206 AW8 LYS F  928  LEU F  930  5                                   3    
HELIX  207 AW9 ILE F  995  SER F 1006  1                                  12    
HELIX  208 AX1 ILE F 1009  TRP F 1036  1                                  28    
HELIX  209 AX2 VAL F 1062  ILE F 1105  1                                  44    
HELIX  210 AX3 PRO F 1108  THR F 1115  1                                   8    
HELIX  211 AX4 PRO F 1116  SER F 1126  1                                  11    
HELIX  212 AX5 SER F 1126  THR F 1160  1                                  35    
HELIX  213 AX6 PHE F 1163  GLU F 1208  1                                  46    
HELIX  214 AX7 GLY F 1209  ARG F 1217  1                                   9    
HELIX  215 AX8 TYR F 1218  ARG F 1273  1                                  56    
HELIX  216 AX9 ALA F 1277  LYS F 1319  1                                  43    
HELIX  217 AY1 GLY F 1383  ALA F 1390  1                                   8    
HELIX  218 AY2 PHE F 1391  ARG F 1393  5                                   3    
HELIX  219 AY3 PRO F 1413  ARG F 1420  1                                   8    
HELIX  220 AY4 ILE F 1435  ASP F 1440  1                                   6    
HELIX  221 AY5 SER F 1446  ILE F 1456  1                                  11    
HELIX  222 AY6 LEU F 1459  ALA F 1465  1                                   7    
HELIX  223 AY7 THR F 1475  GLU F 1479  5                                   5    
HELIX  224 AY8 SER F 1482  VAL F 1496  1                                  15    
HELIX  225 AY9 ASP F 1512  PHE F 1527  1                                  16    
HELIX  226 AZ1 THR F 1541  ALA F 1545  5                                   5    
HELIX  227 AZ2 LYS F 1561  LYS F 1569  1                                   9    
HELIX  228 AZ3 SER F 1571  LYS F 1581  1                                  11    
SHEET    1 AA1 3 VAL A  44  LYS A  47  0                                        
SHEET    2 AA1 3 ARG D 325  ASP D 329  1  O  VAL D 328   N  ALA A  45           
SHEET    3 AA1 3 VAL D 319  GLU D 322 -1  N  GLU D 322   O  ARG D 325           
SHEET    1 AA2 3 LEU A 181  PHE A 183  0                                        
SHEET    2 AA2 3 ARG A 195  ASP A 204 -1  O  GLY A 203   N  ILE A 182           
SHEET    3 AA2 3 VAL A 188  ARG A 192 -1  N  VAL A 188   O  MET A 199           
SHEET    1 AA3 3 LEU A 181  PHE A 183  0                                        
SHEET    2 AA3 3 ARG A 195  ASP A 204 -1  O  GLY A 203   N  ILE A 182           
SHEET    3 AA3 3 LEU A 255  VAL A 260 -1  O  LEU A 255   N  VAL A 202           
SHEET    1 AA4 4 VAL A 230  ILE A 238  0                                        
SHEET    2 AA4 4 ILE A 210  THR A 224 -1  N  VAL A 219   O  VAL A 236           
SHEET    3 AA4 4 GLU A 282  VAL A 291 -1  O  VAL A 290   N  ILE A 211           
SHEET    4 AA4 4 THR A 297  LEU A 305 -1  O  THR A 302   N  VAL A 285           
SHEET    1 AA5 2 GLN A 313  PHE A 315  0                                        
SHEET    2 AA5 2 THR A 336  LYS A 338 -1  O  ILE A 337   N  ARG A 314           
SHEET    1 AA6 3 VAL A 319  GLU A 322  0                                        
SHEET    2 AA6 3 ARG A 325  ASP A 329 -1  O  ARG A 325   N  GLU A 322           
SHEET    3 AA6 3 VAL B  44  LYS B  47  1  O  ALA B  45   N  VAL A 328           
SHEET    1 AA7 3 VAL C  44  LYS C  47  0                                        
SHEET    2 AA7 3 ARG B 325  ASP B 329  1  O  VAL B 328   N  ALA C  45           
SHEET    3 AA7 3 VAL B 319  GLU B 322 -1  N  GLU B 322   O  ARG B 325           
SHEET    1 AA8 3 LEU C 181  PHE C 183  0                                        
SHEET    2 AA8 3 ARG C 195  ASP C 204 -1  O  GLY C 203   N  ILE C 182           
SHEET    3 AA8 3 VAL C 188  ARG C 192 -1  N  VAL C 188   O  MET C 199           
SHEET    1 AA9 3 LEU C 181  PHE C 183  0                                        
SHEET    2 AA9 3 ARG C 195  ASP C 204 -1  O  GLY C 203   N  ILE C 182           
SHEET    3 AA9 3 LEU C 255  VAL C 260 -1  O  LEU C 255   N  VAL C 202           
SHEET    1 AB1 4 VAL C 230  ILE C 238  0                                        
SHEET    2 AB1 4 ILE C 210  THR C 224 -1  N  VAL C 219   O  VAL C 236           
SHEET    3 AB1 4 GLU C 282  VAL C 291 -1  O  VAL C 290   N  ILE C 211           
SHEET    4 AB1 4 THR C 297  LEU C 305 -1  O  THR C 302   N  VAL C 285           
SHEET    1 AB2 2 GLN C 313  PHE C 315  0                                        
SHEET    2 AB2 2 THR C 336  LYS C 338 -1  O  ILE C 337   N  ARG C 314           
SHEET    1 AB3 3 VAL C 319  GLU C 322  0                                        
SHEET    2 AB3 3 ARG C 325  ASP C 329 -1  O  ARG C 325   N  GLU C 322           
SHEET    3 AB3 3 VAL D  44  LYS D  47  1  O  ALA D  45   N  TYR C 326           
SHEET    1 AB4 3 LEU B 181  PHE B 183  0                                        
SHEET    2 AB4 3 ARG B 195  ASP B 204 -1  O  GLY B 203   N  ILE B 182           
SHEET    3 AB4 3 VAL B 188  ARG B 192 -1  N  VAL B 188   O  MET B 199           
SHEET    1 AB5 3 LEU B 181  PHE B 183  0                                        
SHEET    2 AB5 3 ARG B 195  ASP B 204 -1  O  GLY B 203   N  ILE B 182           
SHEET    3 AB5 3 LEU B 255  VAL B 260 -1  O  LEU B 255   N  VAL B 202           
SHEET    1 AB6 4 VAL B 230  ILE B 238  0                                        
SHEET    2 AB6 4 ILE B 210  THR B 224 -1  N  VAL B 219   O  VAL B 236           
SHEET    3 AB6 4 GLU B 282  VAL B 291 -1  O  VAL B 290   N  ILE B 211           
SHEET    4 AB6 4 THR B 297  LEU B 305 -1  O  THR B 302   N  VAL B 285           
SHEET    1 AB7 2 GLN B 313  PHE B 315  0                                        
SHEET    2 AB7 2 THR B 336  LYS B 338 -1  O  ILE B 337   N  ARG B 314           
SHEET    1 AB8 3 LEU D 181  PHE D 183  0                                        
SHEET    2 AB8 3 ARG D 195  ASP D 204 -1  O  GLY D 203   N  ILE D 182           
SHEET    3 AB8 3 VAL D 188  ARG D 192 -1  N  VAL D 188   O  MET D 199           
SHEET    1 AB9 3 LEU D 181  PHE D 183  0                                        
SHEET    2 AB9 3 ARG D 195  ASP D 204 -1  O  GLY D 203   N  ILE D 182           
SHEET    3 AB9 3 LEU D 255  VAL D 260 -1  O  LEU D 255   N  VAL D 202           
SHEET    1 AC1 4 VAL D 230  ILE D 238  0                                        
SHEET    2 AC1 4 ILE D 210  THR D 224 -1  N  VAL D 219   O  VAL D 236           
SHEET    3 AC1 4 GLU D 282  VAL D 291 -1  O  VAL D 290   N  ILE D 211           
SHEET    4 AC1 4 THR D 297  LEU D 305 -1  O  THR D 302   N  VAL D 285           
SHEET    1 AC2 2 GLN D 313  PHE D 315  0                                        
SHEET    2 AC2 2 THR D 336  LYS D 338 -1  O  ILE D 337   N  ARG D 314           
SHEET    1 AC3 3 LEU E 696  ARG E 702  0                                        
SHEET    2 AC3 3 GLN E 680  PHE E 686 -1  N  PHE E 686   O  LEU E 696           
SHEET    3 AC3 3 LYS E 732  PHE E 738 -1  O  SER E 734   N  TYR E 685           
SHEET    1 AC4 5 VAL E 849  ASP E 853  0                                        
SHEET    2 AC4 5 THR E 882  VAL E 886  1  O  THR E 882   N  VAL E 850           
SHEET    3 AC4 5 LEU E 708  GLY E 713  1  N  THR E 709   O  VAL E 883           
SHEET    4 AC4 5 TRP E 898  LYS E 903  1  O  ILE E 900   N  VAL E 712           
SHEET    5 AC4 5 THR E 906  GLU E 910 -1  O  THR E 906   N  LYS E 903           
SHEET    1 AC5 4 ALA E1366  ILE E1368  0                                        
SHEET    2 AC5 4 ILE E1344  SER E1350 -1  N  ILE E1346   O  ALA E1366           
SHEET    3 AC5 4 GLU E1399  ILE E1404 -1  O  ILE E1403   N  GLN E1345           
SHEET    4 AC5 4 ILE E1407  ASP E1408 -1  O  ILE E1407   N  ILE E1404           
SHEET    1 AC6 6 SER E1422  ILE E1424  0                                        
SHEET    2 AC6 6 ILE E1501  ASP E1505  1  O  ASP E1505   N  ILE E1424           
SHEET    3 AC6 6 THR E1531  ILE E1535  1  O  VAL E1533   N  MET E1504           
SHEET    4 AC6 6 ILE E1374  CYS E1377  1  N  ILE E1374   O  VAL E1532           
SHEET    5 AC6 6 VAL E1548  LYS E1552  1  O  ILE E1549   N  GLY E1375           
SHEET    6 AC6 6 ALA E1555  ILE E1556 -1  O  ALA E1555   N  LYS E1552           
SHEET    1 AC7 2 GLY E1433  THR E1434  0                                        
SHEET    2 AC7 2 ILE E1473  ILE E1474 -1  O  ILE E1474   N  GLY E1433           
SHEET    1 AC8 3 LEU H 696  ARG H 702  0                                        
SHEET    2 AC8 3 GLN H 680  PHE H 686 -1  N  PHE H 686   O  LEU H 696           
SHEET    3 AC8 3 LYS H 732  PHE H 738 -1  O  SER H 734   N  TYR H 685           
SHEET    1 AC9 5 VAL H 849  ASP H 853  0                                        
SHEET    2 AC9 5 THR H 882  VAL H 886  1  O  THR H 882   N  VAL H 850           
SHEET    3 AC9 5 LEU H 708  GLY H 713  1  N  THR H 709   O  VAL H 883           
SHEET    4 AC9 5 TRP H 898  LYS H 903  1  O  ILE H 900   N  VAL H 712           
SHEET    5 AC9 5 THR H 906  GLU H 910 -1  O  THR H 906   N  LYS H 903           
SHEET    1 AD1 4 ALA H1366  ILE H1368  0                                        
SHEET    2 AD1 4 ILE H1344  SER H1350 -1  N  ILE H1346   O  ALA H1366           
SHEET    3 AD1 4 GLU H1399  ILE H1404 -1  O  ILE H1403   N  GLN H1345           
SHEET    4 AD1 4 ILE H1407  ASP H1408 -1  O  ILE H1407   N  ILE H1404           
SHEET    1 AD2 6 SER H1422  ILE H1424  0                                        
SHEET    2 AD2 6 ILE H1501  ASP H1505  1  O  ASP H1505   N  ILE H1424           
SHEET    3 AD2 6 THR H1531  ILE H1535  1  O  VAL H1533   N  MET H1504           
SHEET    4 AD2 6 ILE H1374  CYS H1377  1  N  ILE H1374   O  VAL H1532           
SHEET    5 AD2 6 VAL H1548  LYS H1552  1  O  ILE H1549   N  GLY H1375           
SHEET    6 AD2 6 ALA H1555  ILE H1556 -1  O  ALA H1555   N  LYS H1552           
SHEET    1 AD3 2 GLY H1433  THR H1434  0                                        
SHEET    2 AD3 2 ILE H1473  ILE H1474 -1  O  ILE H1474   N  GLY H1433           
SHEET    1 AD4 3 LEU G 696  ARG G 702  0                                        
SHEET    2 AD4 3 GLN G 680  PHE G 686 -1  N  PHE G 686   O  LEU G 696           
SHEET    3 AD4 3 LYS G 732  PHE G 738 -1  O  SER G 734   N  TYR G 685           
SHEET    1 AD5 5 VAL G 849  ASP G 853  0                                        
SHEET    2 AD5 5 THR G 882  VAL G 886  1  O  THR G 882   N  VAL G 850           
SHEET    3 AD5 5 LEU G 708  GLY G 713  1  N  THR G 709   O  VAL G 883           
SHEET    4 AD5 5 TRP G 898  LYS G 903  1  O  ILE G 900   N  VAL G 712           
SHEET    5 AD5 5 THR G 906  GLU G 910 -1  O  THR G 906   N  LYS G 903           
SHEET    1 AD6 4 ALA G1366  ILE G1368  0                                        
SHEET    2 AD6 4 ILE G1344  SER G1350 -1  N  ILE G1346   O  ALA G1366           
SHEET    3 AD6 4 GLU G1399  ILE G1404 -1  O  ILE G1403   N  GLN G1345           
SHEET    4 AD6 4 ILE G1407  ASP G1408 -1  O  ILE G1407   N  ILE G1404           
SHEET    1 AD7 6 SER G1422  ILE G1424  0                                        
SHEET    2 AD7 6 ILE G1501  ASP G1505  1  O  ASP G1505   N  ILE G1424           
SHEET    3 AD7 6 THR G1531  ILE G1535  1  O  VAL G1533   N  MET G1504           
SHEET    4 AD7 6 ILE G1374  CYS G1377  1  N  ILE G1374   O  VAL G1532           
SHEET    5 AD7 6 VAL G1548  LYS G1552  1  O  ILE G1549   N  GLY G1375           
SHEET    6 AD7 6 ALA G1555  ILE G1556 -1  O  ALA G1555   N  LYS G1552           
SHEET    1 AD8 2 GLY G1433  THR G1434  0                                        
SHEET    2 AD8 2 ILE G1473  ILE G1474 -1  O  ILE G1474   N  GLY G1433           
SHEET    1 AD9 3 LEU F 696  ARG F 702  0                                        
SHEET    2 AD9 3 GLN F 680  PHE F 686 -1  N  PHE F 686   O  LEU F 696           
SHEET    3 AD9 3 LYS F 732  PHE F 738 -1  O  SER F 734   N  TYR F 685           
SHEET    1 AE1 5 VAL F 849  ASP F 853  0                                        
SHEET    2 AE1 5 THR F 882  VAL F 886  1  O  THR F 882   N  VAL F 850           
SHEET    3 AE1 5 LEU F 708  GLY F 713  1  N  THR F 709   O  VAL F 883           
SHEET    4 AE1 5 TRP F 898  LYS F 903  1  O  ILE F 900   N  VAL F 712           
SHEET    5 AE1 5 THR F 906  GLU F 910 -1  O  THR F 906   N  LYS F 903           
SHEET    1 AE2 4 ALA F1366  ILE F1368  0                                        
SHEET    2 AE2 4 ILE F1344  SER F1350 -1  N  ILE F1346   O  ALA F1366           
SHEET    3 AE2 4 GLU F1399  ILE F1404 -1  O  ILE F1403   N  GLN F1345           
SHEET    4 AE2 4 ILE F1407  ASP F1408 -1  O  ILE F1407   N  ILE F1404           
SHEET    1 AE3 6 SER F1422  ILE F1424  0                                        
SHEET    2 AE3 6 ILE F1501  ASP F1505  1  O  ASP F1505   N  ILE F1424           
SHEET    3 AE3 6 THR F1531  ILE F1535  1  O  VAL F1533   N  MET F1504           
SHEET    4 AE3 6 ILE F1374  CYS F1377  1  N  ILE F1374   O  VAL F1532           
SHEET    5 AE3 6 VAL F1548  LYS F1552  1  O  ILE F1549   N  GLY F1375           
SHEET    6 AE3 6 ALA F1555  ILE F1556 -1  O  ALA F1555   N  LYS F1552           
SHEET    1 AE4 2 GLY F1433  THR F1434  0                                        
SHEET    2 AE4 2 ILE F1473  ILE F1474 -1  O  ILE F1474   N  GLY F1433           
SSBOND   1 CYS A  110    CYS A  142                          1555   1555  2.04  
SSBOND   2 CYS C  110    CYS C  142                          1555   1555  2.04  
SSBOND   3 CYS B  110    CYS B  142                          1555   1555  2.04  
SSBOND   4 CYS D  110    CYS D  142                          1555   1555  2.04  
SSBOND   5 CYS E    6    CYS E   26                          1555   1555  2.04  
SSBOND   6 CYS H    6    CYS H   26                          1555   1555  2.04  
SSBOND   7 CYS G    6    CYS G   26                          1555   1555  2.04  
SSBOND   8 CYS F    6    CYS F   26                          1555   1555  2.04  
LINK         O   THR A 130                 K     K A 504     1555   1555  2.87  
LINK         OG1 THR A 130                 K     K A 504     1555   1555  3.06  
LINK         O   ILE A 131                 K     K A 503     1555   1555  2.67  
LINK         O   GLY A 132                 K     K A 503     1555   1555  2.95  
LINK         O   PHE A 133                 K     K A 502     1555   1555  2.69  
LINK         O   THR C 130                 K     K A 504     1555   1555  2.96  
LINK         OG1 THR C 130                 K     K A 504     1555   1555  3.13  
LINK         O   ILE C 131                 K     K A 503     1555   1555  2.70  
LINK         O   GLY C 132                 K     K A 503     1555   1555  3.02  
LINK         O   PHE C 133                 K     K A 502     1555   1555  2.74  
LINK         O   THR B 130                 K     K A 504     1555   1555  2.80  
LINK         OG1 THR B 130                 K     K A 504     1555   1555  3.05  
LINK         O   ILE B 131                 K     K A 503     1555   1555  2.62  
LINK         O   GLY B 132                 K     K A 503     1555   1555  2.89  
LINK         O   PHE B 133                 K     K A 502     1555   1555  2.66  
LINK         O   THR D 130                 K     K A 504     1555   1555  2.84  
LINK         OG1 THR D 130                 K     K A 504     1555   1555  3.08  
LINK         O   ILE D 131                 K     K A 503     1555   1555  2.62  
LINK         O   GLY D 132                 K     K A 503     1555   1555  2.91  
LINK         O   PHE D 133                 K     K A 502     1555   1555  2.70  
LINK         OG  SER E 720                MG    MG E2002     1555   1555  2.70  
LINK         OE1 GLN E 774                MG    MG E2002     1555   1555  2.78  
LINK         OG  SER H 720                MG    MG H2002     1555   1555  2.70  
LINK         OE1 GLN H 774                MG    MG H2002     1555   1555  2.78  
LINK         OG  SER G 720                MG    MG G2002     1555   1555  2.70  
LINK         OE1 GLN G 774                MG    MG G2002     1555   1555  2.79  
LINK         OG  SER F 720                MG    MG F2002     1555   1555  2.70  
LINK         OE1 GLN F 774                MG    MG F2002     1555   1555  2.79  
LINK         O1B ADP E2001                MG    MG E2003     1555   1555  1.89  
LINK         O1A ADP E2001                MG    MG E2003     1555   1555  2.77  
LINK         O3A ADP E2001                MG    MG E2003     1555   1555  2.09  
LINK        MG    MG E2002                 O3A ATP E2004     1555   1555  2.96  
LINK        MG    MG E2002                 O1B ATP E2004     1555   1555  1.99  
LINK        MG    MG E2002                 O3B ATP E2004     1555   1555  1.99  
LINK         O1B ADP H2001                MG    MG H2003     1555   1555  1.89  
LINK         O1A ADP H2001                MG    MG H2003     1555   1555  2.77  
LINK         O3A ADP H2001                MG    MG H2003     1555   1555  2.09  
LINK        MG    MG H2002                 O3A ATP H2004     1555   1555  2.96  
LINK        MG    MG H2002                 O3B ATP H2004     1555   1555  1.99  
LINK        MG    MG H2002                 O1B ATP H2004     1555   1555  1.99  
LINK         O1B ADP G2001                MG    MG G2003     1555   1555  1.89  
LINK         O1A ADP G2001                MG    MG G2003     1555   1555  2.77  
LINK         O3A ADP G2001                MG    MG G2003     1555   1555  2.09  
LINK        MG    MG G2002                 O3A ATP G2004     1555   1555  2.96  
LINK        MG    MG G2002                 O3B ATP G2004     1555   1555  1.99  
LINK        MG    MG G2002                 O1B ATP G2004     1555   1555  1.99  
LINK         O1B ADP F2001                MG    MG F2003     1555   1555  1.89  
LINK         O1A ADP F2001                MG    MG F2003     1555   1555  2.77  
LINK         O3A ADP F2001                MG    MG F2003     1555   1555  2.09  
LINK        MG    MG F2002                 O3A ATP F2004     1555   1555  2.96  
LINK        MG    MG F2002                 O1B ATP F2004     1555   1555  1.98  
LINK        MG    MG F2002                 O3B ATP F2004     1555   1555  1.99  
SITE     1 AC1  9 PHE A 183  LYS A 185  TYR A 330  SER A 331                    
SITE     2 AC1  9 GLY A 334  ASN B  48  ILE B  49  ARG B  50                    
SITE     3 AC1  9 GLU B  51                                                     
SITE     1 AC2  7 PHE A 133  GLY A 134  PHE B 133  GLY B 134                    
SITE     2 AC2  7 PHE C 133  PHE D 133  GLY D 134                               
SITE     1 AC3  8 ILE A 131  GLY A 132  ILE B 131  GLY B 132                    
SITE     2 AC3  8 ILE C 131  GLY C 132  ILE D 131  GLY D 132                    
SITE     1 AC4  4 THR A 130  THR B 130  THR C 130  THR D 130                    
SITE     1 AC5 11 ILE C 182  PHE C 183  LYS C 185  TYR C 330                    
SITE     2 AC5 11 SER C 331  LYS C 332  PHE C 333  ASN D  48                    
SITE     3 AC5 11 ILE D  49  ARG D  50  GLU D  51                               
SITE     1 AC6 10 PHE B 183  LYS B 185  TYR B 330  SER B 331                    
SITE     2 AC6 10 LYS B 332  PHE B 333  ASN C  48  ILE C  49                    
SITE     3 AC6 10 ARG C  50  GLU C  51                                          
SITE     1 AC7 11 ASN A  48  ILE A  49  ARG A  50  GLU A  51                    
SITE     2 AC7 11 ILE D 182  PHE D 183  LYS D 185  TYR D 330                    
SITE     3 AC7 11 SER D 331  LYS D 332  PHE D 333                               
SITE     1 AC8 10 ARG E1110  TYR E1353  THR E1380  GLY E1381                    
SITE     2 AC8 10 SER E1382  GLY E1383  LYS E1384  SER E1385                    
SITE     3 AC8 10 SER E1386   MG E2003                                          
SITE     1 AC9  4 SER E 720  GLN E 774  SER E1482  ATP E2004                    
SITE     1 AD1  2 SER E1385  ADP E2001                                          
SITE     1 AD2 16 SER E 408  MET E 409  TRP E 688  VAL E 715                    
SITE     2 AD2 16 GLY E 716  CYS E 717  GLY E 718  LYS E 719                    
SITE     3 AD2 16 SER E 720  SER E 721  GLN E 774  ASP E 854                    
SITE     4 AD2 16 PHE E1481  SER E1482  GLY E1484   MG E2002                    
SITE     1 AD3 10 ARG H1110  TYR H1353  THR H1380  GLY H1381                    
SITE     2 AD3 10 SER H1382  GLY H1383  LYS H1384  SER H1385                    
SITE     3 AD3 10 SER H1386   MG H2003                                          
SITE     1 AD4  4 SER H 720  GLN H 774  SER H1482  ATP H2004                    
SITE     1 AD5  2 SER H1385  ADP H2001                                          
SITE     1 AD6 16 SER H 408  MET H 409  TRP H 688  VAL H 715                    
SITE     2 AD6 16 GLY H 716  CYS H 717  GLY H 718  LYS H 719                    
SITE     3 AD6 16 SER H 720  SER H 721  GLN H 774  ASP H 854                    
SITE     4 AD6 16 PHE H1481  SER H1482  GLY H1484   MG H2002                    
SITE     1 AD7 10 ARG G1110  TYR G1353  THR G1380  GLY G1381                    
SITE     2 AD7 10 SER G1382  GLY G1383  LYS G1384  SER G1385                    
SITE     3 AD7 10 SER G1386   MG G2003                                          
SITE     1 AD8  4 SER G 720  GLN G 774  SER G1482  ATP G2004                    
SITE     1 AD9  2 SER G1385  ADP G2001                                          
SITE     1 AE1 16 SER G 408  MET G 409  TRP G 688  VAL G 715                    
SITE     2 AE1 16 GLY G 716  CYS G 717  GLY G 718  LYS G 719                    
SITE     3 AE1 16 SER G 720  SER G 721  GLN G 774  ASP G 854                    
SITE     4 AE1 16 PHE G1481  SER G1482  GLY G1484   MG G2002                    
SITE     1 AE2 10 ARG F1110  TYR F1353  THR F1380  GLY F1381                    
SITE     2 AE2 10 SER F1382  GLY F1383  LYS F1384  SER F1385                    
SITE     3 AE2 10 SER F1386   MG F2003                                          
SITE     1 AE3  4 SER F 720  GLN F 774  SER F1482  ATP F2004                    
SITE     1 AE4  2 SER F1385  ADP F2001                                          
SITE     1 AE5 16 SER F 408  MET F 409  TRP F 688  VAL F 715                    
SITE     2 AE5 16 GLY F 716  CYS F 717  GLY F 718  LYS F 719                    
SITE     3 AE5 16 SER F 720  SER F 721  GLN F 774  ASP F 854                    
SITE     4 AE5 16 PHE F1481  SER F1482  GLY F1484   MG F2002                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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