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Database: PDB
Entry: 6CAJ
LinkDB: 6CAJ
Original site: 6CAJ 
HEADER    TRANSLATION                             31-JAN-18   6CAJ              
TITLE     ELECTRON CRYO-MICROSCOPY OF THE EUKARYOTIC TRANSLATION INITIATION     
TITLE    2 FACTOR 2B FROM HOMO SAPIENS                                          
CAVEAT     6CAJ    RESIDUES ILE 267 AND THR 272 IN CHAINS I, J ARE LINKED       
CAVEAT   2 6CAJ    TOGETHER IN THE MODEL BUT THERE ARE RESIDUES BETWEEN THEM    
CAVEAT   3 6CAJ    IN THE SEQUENCE                                              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON;      
COMPND   3 CHAIN: B, A;                                                         
COMPND   4 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT EPSILON;             
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA;        
COMPND   8 CHAIN: J, I;                                                         
COMPND   9 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT GAMMA;               
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA;        
COMPND  13 CHAIN: H, G;                                                         
COMPND  14 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT ALPHA;               
COMPND  15 ENGINEERED: YES;                                                     
COMPND  16 MOL_ID: 4;                                                           
COMPND  17 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA;         
COMPND  18 CHAIN: C, D;                                                         
COMPND  19 SYNONYM: S20I15,S20III15,EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT BETA;
COMPND  20 ENGINEERED: YES;                                                     
COMPND  21 MOL_ID: 5;                                                           
COMPND  22 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA;        
COMPND  23 CHAIN: F, E;                                                         
COMPND  24 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT DELTA;               
COMPND  25 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: EIF2B5, EIF2BE;                                                
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: EIF2B3;                                                        
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 GENE: EIF2B1, EIF2BA;                                                
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  24 ORGANISM_COMMON: HUMAN;                                              
SOURCE  25 ORGANISM_TAXID: 9606;                                                
SOURCE  26 GENE: EIF2B2, EIF2BB;                                                
SOURCE  27 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  28 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  29 MOL_ID: 5;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  31 ORGANISM_COMMON: HUMAN;                                              
SOURCE  32 ORGANISM_TAXID: 9606;                                                
SOURCE  33 GENE: EIF2B4, EIF2BD;                                                
SOURCE  34 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  35 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    GUANINE NUCLEOTIDE EXCHANGE FACTOR, TRANSLATION INITIATION, ISRIB-    
KEYWDS   2 BOUND, DECAMERIC COMPLEX, TRANSLATION                                
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    J.C.TSAI,L.E.MILLER-VEDAM,A.A.ANAND,P.JAISHANKAR,H.C.NGUYEN,          
AUTHOR   2 A.R.RENSLO,A.FROST,P.WALTER                                          
REVDAT   3   20-NOV-19 6CAJ    1       SEQADV HETSYN                            
REVDAT   2   20-FEB-19 6CAJ    1       REMARK                                   
REVDAT   1   11-APR-18 6CAJ    0                                                
JRNL        AUTH   J.C.TSAI,L.E.MILLER-VEDAM,A.A.ANAND,P.JAISHANKAR,H.C.NGUYEN, 
JRNL        AUTH 2 A.R.RENSLO,A.FROST,P.WALTER                                  
JRNL        TITL   STRUCTURE OF THE NUCLEOTIDE EXCHANGE FACTOR EIF2B REVEALS    
JRNL        TITL 2 MECHANISM OF MEMORY-ENHANCING MOLECULE.                      
JRNL        REF    SCIENCE                       V. 359       2018              
JRNL        REFN                   ESSN 1095-9203                               
JRNL        PMID   29599213                                                     
JRNL        DOI    10.1126/SCIENCE.AAQ0939                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.80 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : GAUTOMATCH, SERIALEM, GCTF, UCSF          
REMARK   3                            CHIMERA, RELION, FREALIGN, FREALIGN,      
REMARK   3                            PHENIX                                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 2.800                          
REMARK   3   NUMBER OF PARTICLES               : 202125                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6CAJ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 01-FEB-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000232379.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : TRANSLATION INITIATION FACTOR     
REMARK 245                                    EIF-2B DECAMER                    
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 1.63                           
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DECAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, J, H, C, F, A, I, G, D, E          
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     ALA B     3                                                      
REMARK 465     PRO B     4                                                      
REMARK 465     VAL B     5                                                      
REMARK 465     VAL B     6                                                      
REMARK 465     ALA B     7                                                      
REMARK 465     PRO B     8                                                      
REMARK 465     PRO B     9                                                      
REMARK 465     GLY B    10                                                      
REMARK 465     VAL B    11                                                      
REMARK 465     VAL B    12                                                      
REMARK 465     VAL B    13                                                      
REMARK 465     SER B    14                                                      
REMARK 465     ARG B    15                                                      
REMARK 465     ALA B    16                                                      
REMARK 465     ASN B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     ARG B    19                                                      
REMARK 465     SER B    20                                                      
REMARK 465     GLY B    21                                                      
REMARK 465     ALA B    22                                                      
REMARK 465     GLY B    23                                                      
REMARK 465     PRO B    24                                                      
REMARK 465     GLY B    25                                                      
REMARK 465     GLY B    26                                                      
REMARK 465     SER B    27                                                      
REMARK 465     GLY B    28                                                      
REMARK 465     GLY B    29                                                      
REMARK 465     GLY B    30                                                      
REMARK 465     GLY B    31                                                      
REMARK 465     ALA B    32                                                      
REMARK 465     ARG B    33                                                      
REMARK 465     GLY B    34                                                      
REMARK 465     ALA B    35                                                      
REMARK 465     GLU B    36                                                      
REMARK 465     GLU B    37                                                      
REMARK 465     GLU B    38                                                      
REMARK 465     PRO B    39                                                      
REMARK 465     PRO B    40                                                      
REMARK 465     GLU B   280                                                      
REMARK 465     GLU B   281                                                      
REMARK 465     ILE B   282                                                      
REMARK 465     LEU B   283                                                      
REMARK 465     GLY B   284                                                      
REMARK 465     ASP B   467                                                      
REMARK 465     ASP B   468                                                      
REMARK 465     SER B   469                                                      
REMARK 465     GLY B   470                                                      
REMARK 465     ALA B   471                                                      
REMARK 465     ASP B   472                                                      
REMARK 465     GLN B   473                                                      
REMARK 465     GLU B   474                                                      
REMARK 465     LYS B   475                                                      
REMARK 465     ASP B   476                                                      
REMARK 465     LYS B   477                                                      
REMARK 465     VAL B   478                                                      
REMARK 465     LYS B   479                                                      
REMARK 465     MET B   480                                                      
REMARK 465     LYS B   481                                                      
REMARK 465     GLY B   482                                                      
REMARK 465     TYR B   483                                                      
REMARK 465     ASN B   484                                                      
REMARK 465     PRO B   485                                                      
REMARK 465     ALA B   486                                                      
REMARK 465     GLU B   487                                                      
REMARK 465     VAL B   488                                                      
REMARK 465     GLY B   489                                                      
REMARK 465     ALA B   490                                                      
REMARK 465     ALA B   491                                                      
REMARK 465     GLY B   492                                                      
REMARK 465     LYS B   493                                                      
REMARK 465     GLY B   494                                                      
REMARK 465     TYR B   495                                                      
REMARK 465     LEU B   496                                                      
REMARK 465     TRP B   497                                                      
REMARK 465     LYS B   498                                                      
REMARK 465     ALA B   499                                                      
REMARK 465     ALA B   500                                                      
REMARK 465     GLY B   501                                                      
REMARK 465     MET B   502                                                      
REMARK 465     ASN B   503                                                      
REMARK 465     MET B   504                                                      
REMARK 465     GLU B   505                                                      
REMARK 465     GLU B   506                                                      
REMARK 465     GLU B   507                                                      
REMARK 465     GLU B   508                                                      
REMARK 465     GLU B   509                                                      
REMARK 465     LEU B   510                                                      
REMARK 465     GLN B   511                                                      
REMARK 465     GLN B   512                                                      
REMARK 465     ASN B   513                                                      
REMARK 465     LEU B   514                                                      
REMARK 465     TRP B   515                                                      
REMARK 465     GLY B   516                                                      
REMARK 465     LEU B   517                                                      
REMARK 465     LYS B   518                                                      
REMARK 465     ILE B   519                                                      
REMARK 465     ASN B   520                                                      
REMARK 465     MET B   521                                                      
REMARK 465     GLU B   522                                                      
REMARK 465     GLU B   523                                                      
REMARK 465     GLU B   524                                                      
REMARK 465     SER B   525                                                      
REMARK 465     GLU B   526                                                      
REMARK 465     SER B   527                                                      
REMARK 465     GLU B   528                                                      
REMARK 465     SER B   529                                                      
REMARK 465     GLU B   530                                                      
REMARK 465     GLN B   531                                                      
REMARK 465     SER B   532                                                      
REMARK 465     MET B   533                                                      
REMARK 465     ASP B   534                                                      
REMARK 465     SER B   535                                                      
REMARK 465     GLU B   536                                                      
REMARK 465     GLU B   537                                                      
REMARK 465     PRO B   538                                                      
REMARK 465     ASP B   539                                                      
REMARK 465     SER B   540                                                      
REMARK 465     ARG B   541                                                      
REMARK 465     GLY B   542                                                      
REMARK 465     GLY B   543                                                      
REMARK 465     SER B   544                                                      
REMARK 465     PRO B   545                                                      
REMARK 465     GLN B   546                                                      
REMARK 465     MET B   547                                                      
REMARK 465     ASP B   548                                                      
REMARK 465     ASP B   549                                                      
REMARK 465     ILE B   550                                                      
REMARK 465     LYS B   551                                                      
REMARK 465     VAL B   552                                                      
REMARK 465     PHE B   553                                                      
REMARK 465     GLN B   554                                                      
REMARK 465     ASN B   555                                                      
REMARK 465     GLU B   556                                                      
REMARK 465     VAL B   557                                                      
REMARK 465     LEU B   558                                                      
REMARK 465     GLY B   559                                                      
REMARK 465     THR B   560                                                      
REMARK 465     LEU B   561                                                      
REMARK 465     GLN B   562                                                      
REMARK 465     ARG B   563                                                      
REMARK 465     GLY B   564                                                      
REMARK 465     LYS B   565                                                      
REMARK 465     GLU B   566                                                      
REMARK 465     GLU B   567                                                      
REMARK 465     ASN B   568                                                      
REMARK 465     ILE B   569                                                      
REMARK 465     SER B   570                                                      
REMARK 465     CYS B   571                                                      
REMARK 465     ASP B   572                                                      
REMARK 465     ASN B   573                                                      
REMARK 465     LEU B   574                                                      
REMARK 465     VAL B   575                                                      
REMARK 465     LEU B   576                                                      
REMARK 465     GLU B   577                                                      
REMARK 465     ILE B   578                                                      
REMARK 465     ASN B   579                                                      
REMARK 465     SER B   580                                                      
REMARK 465     LEU B   581                                                      
REMARK 465     LYS B   582                                                      
REMARK 465     TYR B   583                                                      
REMARK 465     ALA B   584                                                      
REMARK 465     TYR B   585                                                      
REMARK 465     ASN B   586                                                      
REMARK 465     VAL B   587                                                      
REMARK 465     SER B   588                                                      
REMARK 465     LEU B   589                                                      
REMARK 465     LYS B   590                                                      
REMARK 465     GLU B   591                                                      
REMARK 465     VAL B   592                                                      
REMARK 465     MET B   593                                                      
REMARK 465     GLN B   594                                                      
REMARK 465     VAL B   595                                                      
REMARK 465     LEU B   596                                                      
REMARK 465     SER B   597                                                      
REMARK 465     HIS B   598                                                      
REMARK 465     VAL B   599                                                      
REMARK 465     VAL B   600                                                      
REMARK 465     LEU B   601                                                      
REMARK 465     GLU B   602                                                      
REMARK 465     PHE B   603                                                      
REMARK 465     PRO B   604                                                      
REMARK 465     LEU B   605                                                      
REMARK 465     GLN B   606                                                      
REMARK 465     GLN B   607                                                      
REMARK 465     MET B   608                                                      
REMARK 465     ASP B   609                                                      
REMARK 465     SER B   610                                                      
REMARK 465     PRO B   611                                                      
REMARK 465     LEU B   612                                                      
REMARK 465     ASP B   613                                                      
REMARK 465     SER B   614                                                      
REMARK 465     SER B   615                                                      
REMARK 465     ARG B   616                                                      
REMARK 465     TYR B   617                                                      
REMARK 465     CYS B   618                                                      
REMARK 465     ALA B   619                                                      
REMARK 465     LEU B   620                                                      
REMARK 465     LEU B   621                                                      
REMARK 465     LEU B   622                                                      
REMARK 465     PRO B   623                                                      
REMARK 465     LEU B   624                                                      
REMARK 465     LEU B   625                                                      
REMARK 465     LYS B   626                                                      
REMARK 465     ALA B   627                                                      
REMARK 465     TRP B   628                                                      
REMARK 465     SER B   629                                                      
REMARK 465     PRO B   630                                                      
REMARK 465     VAL B   631                                                      
REMARK 465     PHE B   632                                                      
REMARK 465     ARG B   633                                                      
REMARK 465     ASN B   634                                                      
REMARK 465     TYR B   635                                                      
REMARK 465     ILE B   636                                                      
REMARK 465     LYS B   637                                                      
REMARK 465     ARG B   638                                                      
REMARK 465     ALA B   639                                                      
REMARK 465     ALA B   640                                                      
REMARK 465     ASP B   641                                                      
REMARK 465     HIS B   642                                                      
REMARK 465     LEU B   643                                                      
REMARK 465     GLU B   644                                                      
REMARK 465     ALA B   645                                                      
REMARK 465     LEU B   646                                                      
REMARK 465     ALA B   647                                                      
REMARK 465     ALA B   648                                                      
REMARK 465     ILE B   649                                                      
REMARK 465     GLU B   650                                                      
REMARK 465     ASP B   651                                                      
REMARK 465     PHE B   652                                                      
REMARK 465     PHE B   653                                                      
REMARK 465     LEU B   654                                                      
REMARK 465     GLU B   655                                                      
REMARK 465     HIS B   656                                                      
REMARK 465     GLU B   657                                                      
REMARK 465     ALA B   658                                                      
REMARK 465     LEU B   659                                                      
REMARK 465     GLY B   660                                                      
REMARK 465     ILE B   661                                                      
REMARK 465     SER B   662                                                      
REMARK 465     MET B   663                                                      
REMARK 465     ALA B   664                                                      
REMARK 465     LYS B   665                                                      
REMARK 465     VAL B   666                                                      
REMARK 465     LEU B   667                                                      
REMARK 465     MET B   668                                                      
REMARK 465     ALA B   669                                                      
REMARK 465     PHE B   670                                                      
REMARK 465     TYR B   671                                                      
REMARK 465     GLN B   672                                                      
REMARK 465     LEU B   673                                                      
REMARK 465     GLU B   674                                                      
REMARK 465     ILE B   675                                                      
REMARK 465     LEU B   676                                                      
REMARK 465     ALA B   677                                                      
REMARK 465     GLU B   678                                                      
REMARK 465     GLU B   679                                                      
REMARK 465     THR B   680                                                      
REMARK 465     ILE B   681                                                      
REMARK 465     LEU B   682                                                      
REMARK 465     SER B   683                                                      
REMARK 465     TRP B   684                                                      
REMARK 465     PHE B   685                                                      
REMARK 465     SER B   686                                                      
REMARK 465     GLN B   687                                                      
REMARK 465     ARG B   688                                                      
REMARK 465     ASP B   689                                                      
REMARK 465     THR B   690                                                      
REMARK 465     THR B   691                                                      
REMARK 465     ASP B   692                                                      
REMARK 465     LYS B   693                                                      
REMARK 465     GLY B   694                                                      
REMARK 465     GLN B   695                                                      
REMARK 465     GLN B   696                                                      
REMARK 465     LEU B   697                                                      
REMARK 465     ARG B   698                                                      
REMARK 465     LYS B   699                                                      
REMARK 465     ASN B   700                                                      
REMARK 465     GLN B   701                                                      
REMARK 465     GLN B   702                                                      
REMARK 465     LEU B   703                                                      
REMARK 465     GLN B   704                                                      
REMARK 465     ARG B   705                                                      
REMARK 465     PHE B   706                                                      
REMARK 465     ILE B   707                                                      
REMARK 465     GLN B   708                                                      
REMARK 465     TRP B   709                                                      
REMARK 465     LEU B   710                                                      
REMARK 465     LYS B   711                                                      
REMARK 465     GLU B   712                                                      
REMARK 465     ALA B   713                                                      
REMARK 465     GLU B   714                                                      
REMARK 465     GLU B   715                                                      
REMARK 465     GLU B   716                                                      
REMARK 465     SER B   717                                                      
REMARK 465     SER B   718                                                      
REMARK 465     GLU B   719                                                      
REMARK 465     ASP B   720                                                      
REMARK 465     ASP B   721                                                      
REMARK 465     GLY J    13                                                      
REMARK 465     SER J    14                                                      
REMARK 465     ARG J    15                                                      
REMARK 465     MET J    16                                                      
REMARK 465     THR J    17                                                      
REMARK 465     ASP J    18                                                      
REMARK 465     LEU J    19                                                      
REMARK 465     THR J    20                                                      
REMARK 465     GLY J   135                                                      
REMARK 465     GLN J   136                                                      
REMARK 465     ASP J   137                                                      
REMARK 465     SER J   138                                                      
REMARK 465     ILE J   139                                                      
REMARK 465     GLU J   140                                                      
REMARK 465     PRO J   141                                                      
REMARK 465     VAL J   142                                                      
REMARK 465     PRO J   143                                                      
REMARK 465     GLY J   144                                                      
REMARK 465     GLN J   145                                                      
REMARK 465     LYS J   146                                                      
REMARK 465     GLY J   147                                                      
REMARK 465     LYS J   148                                                      
REMARK 465     LYS J   149                                                      
REMARK 465     LYS J   150                                                      
REMARK 465     ALA J   151                                                      
REMARK 465     VAL J   152                                                      
REMARK 465     GLU J   153                                                      
REMARK 465     GLN J   154                                                      
REMARK 465     PHE J   237                                                      
REMARK 465     SER J   238                                                      
REMARK 465     GLN J   244                                                      
REMARK 465     GLY J   245                                                      
REMARK 465     GLN J   246                                                      
REMARK 465     GLU J   247                                                      
REMARK 465     GLU J   248                                                      
REMARK 465     LYS J   249                                                      
REMARK 465     GLU J   250                                                      
REMARK 465     GLU J   251                                                      
REMARK 465     ASP J   252                                                      
REMARK 465     LEU J   253                                                      
REMARK 465     LYS J   254                                                      
REMARK 465     LYS J   255                                                      
REMARK 465     LYS J   256                                                      
REMARK 465     GLU J   257                                                      
REMARK 465     LYS J   268                                                      
REMARK 465     GLU J   269                                                      
REMARK 465     ALA J   270                                                      
REMARK 465     ASN J   271                                                      
REMARK 465     LEU J   293                                                      
REMARK 465     SER J   294                                                      
REMARK 465     ARG J   295                                                      
REMARK 465     SER J   296                                                      
REMARK 465     GLN J   297                                                      
REMARK 465     VAL J   298                                                      
REMARK 465     ARG J   299                                                      
REMARK 465     CYS J   300                                                      
REMARK 465     TYR J   301                                                      
REMARK 465     VAL J   302                                                      
REMARK 465     HIS J   303                                                      
REMARK 465     ILE J   304                                                      
REMARK 465     MET J   305                                                      
REMARK 465     LYS J   306                                                      
REMARK 465     GLU J   307                                                      
REMARK 465     GLY J   308                                                      
REMARK 465     LEU J   309                                                      
REMARK 465     CYS J   310                                                      
REMARK 465     SER J   311                                                      
REMARK 465     ARG J   312                                                      
REMARK 465     VAL J   313                                                      
REMARK 465     SER J   314                                                      
REMARK 465     THR J   315                                                      
REMARK 465     LEU J   316                                                      
REMARK 465     GLY J   317                                                      
REMARK 465     LEU J   318                                                      
REMARK 465     TYR J   319                                                      
REMARK 465     MET J   320                                                      
REMARK 465     GLU J   321                                                      
REMARK 465     ALA J   322                                                      
REMARK 465     ASN J   323                                                      
REMARK 465     ARG J   324                                                      
REMARK 465     GLN J   325                                                      
REMARK 465     VAL J   326                                                      
REMARK 465     PRO J   327                                                      
REMARK 465     LYS J   328                                                      
REMARK 465     LEU J   329                                                      
REMARK 465     LEU J   330                                                      
REMARK 465     SER J   331                                                      
REMARK 465     ALA J   332                                                      
REMARK 465     LEU J   333                                                      
REMARK 465     CYS J   334                                                      
REMARK 465     PRO J   335                                                      
REMARK 465     GLU J   336                                                      
REMARK 465     GLU J   337                                                      
REMARK 465     PRO J   338                                                      
REMARK 465     PRO J   339                                                      
REMARK 465     VAL J   340                                                      
REMARK 465     HIS J   341                                                      
REMARK 465     SER J   342                                                      
REMARK 465     SER J   343                                                      
REMARK 465     ALA J   344                                                      
REMARK 465     GLN J   345                                                      
REMARK 465     ILE J   346                                                      
REMARK 465     VAL J   347                                                      
REMARK 465     SER J   348                                                      
REMARK 465     LYS J   349                                                      
REMARK 465     HIS J   350                                                      
REMARK 465     LEU J   351                                                      
REMARK 465     VAL J   352                                                      
REMARK 465     GLY J   353                                                      
REMARK 465     VAL J   354                                                      
REMARK 465     ASP J   355                                                      
REMARK 465     SER J   356                                                      
REMARK 465     LEU J   357                                                      
REMARK 465     ILE J   358                                                      
REMARK 465     GLY J   359                                                      
REMARK 465     PRO J   360                                                      
REMARK 465     GLU J   361                                                      
REMARK 465     THR J   362                                                      
REMARK 465     GLN J   363                                                      
REMARK 465     ILE J   364                                                      
REMARK 465     GLY J   365                                                      
REMARK 465     GLU J   366                                                      
REMARK 465     LYS J   367                                                      
REMARK 465     SER J   368                                                      
REMARK 465     SER J   369                                                      
REMARK 465     ILE J   370                                                      
REMARK 465     LYS J   371                                                      
REMARK 465     ARG J   372                                                      
REMARK 465     SER J   373                                                      
REMARK 465     VAL J   374                                                      
REMARK 465     ILE J   375                                                      
REMARK 465     GLY J   376                                                      
REMARK 465     SER J   377                                                      
REMARK 465     SER J   378                                                      
REMARK 465     CYS J   379                                                      
REMARK 465     LEU J   380                                                      
REMARK 465     ILE J   381                                                      
REMARK 465     LYS J   382                                                      
REMARK 465     ASP J   383                                                      
REMARK 465     ARG J   384                                                      
REMARK 465     VAL J   385                                                      
REMARK 465     THR J   386                                                      
REMARK 465     ILE J   387                                                      
REMARK 465     THR J   388                                                      
REMARK 465     ASN J   389                                                      
REMARK 465     CYS J   390                                                      
REMARK 465     LEU J   391                                                      
REMARK 465     LEU J   392                                                      
REMARK 465     MET J   393                                                      
REMARK 465     ASN J   394                                                      
REMARK 465     SER J   395                                                      
REMARK 465     VAL J   396                                                      
REMARK 465     THR J   397                                                      
REMARK 465     VAL J   398                                                      
REMARK 465     GLU J   399                                                      
REMARK 465     GLU J   400                                                      
REMARK 465     GLY J   401                                                      
REMARK 465     SER J   402                                                      
REMARK 465     ASN J   403                                                      
REMARK 465     ILE J   404                                                      
REMARK 465     GLN J   405                                                      
REMARK 465     GLY J   406                                                      
REMARK 465     SER J   407                                                      
REMARK 465     VAL J   408                                                      
REMARK 465     ILE J   409                                                      
REMARK 465     CYS J   410                                                      
REMARK 465     ASN J   411                                                      
REMARK 465     ASN J   412                                                      
REMARK 465     ALA J   413                                                      
REMARK 465     VAL J   414                                                      
REMARK 465     ILE J   415                                                      
REMARK 465     GLU J   416                                                      
REMARK 465     LYS J   417                                                      
REMARK 465     GLY J   418                                                      
REMARK 465     ALA J   419                                                      
REMARK 465     ASP J   420                                                      
REMARK 465     ILE J   421                                                      
REMARK 465     LYS J   422                                                      
REMARK 465     ASP J   423                                                      
REMARK 465     CYS J   424                                                      
REMARK 465     LEU J   425                                                      
REMARK 465     ILE J   426                                                      
REMARK 465     GLY J   427                                                      
REMARK 465     SER J   428                                                      
REMARK 465     GLY J   429                                                      
REMARK 465     GLN J   430                                                      
REMARK 465     ARG J   431                                                      
REMARK 465     ILE J   432                                                      
REMARK 465     GLU J   433                                                      
REMARK 465     ALA J   434                                                      
REMARK 465     LYS J   435                                                      
REMARK 465     ALA J   436                                                      
REMARK 465     LYS J   437                                                      
REMARK 465     ARG J   438                                                      
REMARK 465     VAL J   439                                                      
REMARK 465     ASN J   440                                                      
REMARK 465     GLU J   441                                                      
REMARK 465     VAL J   442                                                      
REMARK 465     ILE J   443                                                      
REMARK 465     VAL J   444                                                      
REMARK 465     GLY J   445                                                      
REMARK 465     ASN J   446                                                      
REMARK 465     ASP J   447                                                      
REMARK 465     GLN J   448                                                      
REMARK 465     LEU J   449                                                      
REMARK 465     MET J   450                                                      
REMARK 465     GLU J   451                                                      
REMARK 465     ILE J   452                                                      
REMARK 465     MET H     1                                                      
REMARK 465     ASP H     2                                                      
REMARK 465     ASP H     3                                                      
REMARK 465     ASP H    37                                                      
REMARK 465     LYS H    38                                                      
REMARK 465     GLY H    39                                                      
REMARK 465     GLU H    40                                                      
REMARK 465     THR H    41                                                      
REMARK 465     ILE H    42                                                      
REMARK 465     GLN H    43                                                      
REMARK 465     LEU H    78                                                      
REMARK 465     ALA H    79                                                      
REMARK 465     SER H    80                                                      
REMARK 465     LEU H    81                                                      
REMARK 465     GLU H    82                                                      
REMARK 465     TYR H    83                                                      
REMARK 465     SER H    84                                                      
REMARK 465     ASP H    85                                                      
REMARK 465     TYR H    86                                                      
REMARK 465     SER H    87                                                      
REMARK 465     LYS H    88                                                      
REMARK 465     CYS H    89                                                      
REMARK 465     LYS H    90                                                      
REMARK 465     LYS H   253                                                      
REMARK 465     ALA H   254                                                      
REMARK 465     ASP H   255                                                      
REMARK 465     THR H   256                                                      
REMARK 465     LEU H   257                                                      
REMARK 465     LYS H   258                                                      
REMARK 465     VAL H   259                                                      
REMARK 465     ALA H   260                                                      
REMARK 465     GLN H   261                                                      
REMARK 465     THR H   262                                                      
REMARK 465     GLY H   263                                                      
REMARK 465     GLN H   264                                                      
REMARK 465     ASP H   265                                                      
REMARK 465     LEU H   266                                                      
REMARK 465     LYS H   267                                                      
REMARK 465     GLU H   268                                                      
REMARK 465     GLU H   269                                                      
REMARK 465     MET C   -16                                                      
REMARK 465     HIS C   -15                                                      
REMARK 465     HIS C   -14                                                      
REMARK 465     HIS C   -13                                                      
REMARK 465     HIS C   -12                                                      
REMARK 465     HIS C   -11                                                      
REMARK 465     HIS C   -10                                                      
REMARK 465     GLY C    -9                                                      
REMARK 465     GLY C    -8                                                      
REMARK 465     GLY C    -7                                                      
REMARK 465     SER C    -6                                                      
REMARK 465     GLU C    -5                                                      
REMARK 465     ASN C    -4                                                      
REMARK 465     LEU C    -3                                                      
REMARK 465     TYR C    -2                                                      
REMARK 465     PHE C    -1                                                      
REMARK 465     GLN C     0                                                      
REMARK 465     SER C     1                                                      
REMARK 465     PRO C     2                                                      
REMARK 465     GLY C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     ALA C     6                                                      
REMARK 465     LYS C     7                                                      
REMARK 465     ARG C    99                                                      
REMARK 465     SER C   100                                                      
REMARK 465     ASP C   101                                                      
REMARK 465     GLU C   102                                                      
REMARK 465     SER C   103                                                      
REMARK 465     ASP C   104                                                      
REMARK 465     GLN C   105                                                      
REMARK 465     GLN C   106                                                      
REMARK 465     GLU C   107                                                      
REMARK 465     SER C   108                                                      
REMARK 465     LEU C   109                                                      
REMARK 465     HIS C   110                                                      
REMARK 465     LYS C   111                                                      
REMARK 465     LEU C   112                                                      
REMARK 465     LEU C   113                                                      
REMARK 465     THR C   114                                                      
REMARK 465     SER C   115                                                      
REMARK 465     GLY C   116                                                      
REMARK 465     GLY C   117                                                      
REMARK 465     LEU C   118                                                      
REMARK 465     ASN C   119                                                      
REMARK 465     GLU C   120                                                      
REMARK 465     ASP C   121                                                      
REMARK 465     PHE C   122                                                      
REMARK 465     SER C   123                                                      
REMARK 465     PHE C   124                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ALA F     2                                                      
REMARK 465     ALA F     3                                                      
REMARK 465     VAL F     4                                                      
REMARK 465     ALA F     5                                                      
REMARK 465     VAL F     6                                                      
REMARK 465     ALA F     7                                                      
REMARK 465     VAL F     8                                                      
REMARK 465     ARG F     9                                                      
REMARK 465     GLU F    10                                                      
REMARK 465     ASP F    11                                                      
REMARK 465     SER F    12                                                      
REMARK 465     GLY F    13                                                      
REMARK 465     SER F    14                                                      
REMARK 465     GLY F    15                                                      
REMARK 465     MET F    16                                                      
REMARK 465     LYS F    17                                                      
REMARK 465     ALA F    18                                                      
REMARK 465     GLU F    19                                                      
REMARK 465     LEU F    20                                                      
REMARK 465     PRO F    21                                                      
REMARK 465     PRO F    22                                                      
REMARK 465     GLY F    23                                                      
REMARK 465     PRO F    24                                                      
REMARK 465     GLY F    25                                                      
REMARK 465     ALA F    26                                                      
REMARK 465     VAL F    27                                                      
REMARK 465     GLY F    28                                                      
REMARK 465     ARG F    29                                                      
REMARK 465     GLU F    30                                                      
REMARK 465     MET F    31                                                      
REMARK 465     THR F    32                                                      
REMARK 465     LYS F    33                                                      
REMARK 465     GLU F    34                                                      
REMARK 465     GLU F    35                                                      
REMARK 465     LYS F    36                                                      
REMARK 465     LEU F    37                                                      
REMARK 465     GLN F    38                                                      
REMARK 465     LEU F    39                                                      
REMARK 465     ARG F    40                                                      
REMARK 465     LYS F    41                                                      
REMARK 465     GLU F    42                                                      
REMARK 465     LYS F    43                                                      
REMARK 465     LYS F    44                                                      
REMARK 465     GLN F    45                                                      
REMARK 465     GLN F    46                                                      
REMARK 465     LYS F    47                                                      
REMARK 465     LYS F    48                                                      
REMARK 465     LYS F    49                                                      
REMARK 465     ARG F    50                                                      
REMARK 465     LYS F    51                                                      
REMARK 465     GLU F    52                                                      
REMARK 465     GLU F    53                                                      
REMARK 465     LYS F    54                                                      
REMARK 465     GLY F    55                                                      
REMARK 465     ALA F    56                                                      
REMARK 465     GLU F    57                                                      
REMARK 465     PRO F    58                                                      
REMARK 465     GLU F    59                                                      
REMARK 465     THR F    60                                                      
REMARK 465     GLY F    61                                                      
REMARK 465     SER F    62                                                      
REMARK 465     ALA F    63                                                      
REMARK 465     VAL F    64                                                      
REMARK 465     SER F    65                                                      
REMARK 465     ALA F    66                                                      
REMARK 465     ALA F    67                                                      
REMARK 465     GLN F    68                                                      
REMARK 465     CYS F    69                                                      
REMARK 465     GLN F    70                                                      
REMARK 465     VAL F    71                                                      
REMARK 465     GLY F    72                                                      
REMARK 465     PRO F    73                                                      
REMARK 465     THR F    74                                                      
REMARK 465     ARG F    75                                                      
REMARK 465     GLU F    76                                                      
REMARK 465     LEU F    77                                                      
REMARK 465     PRO F    78                                                      
REMARK 465     GLU F    79                                                      
REMARK 465     SER F    80                                                      
REMARK 465     GLY F    81                                                      
REMARK 465     ILE F    82                                                      
REMARK 465     GLN F    83                                                      
REMARK 465     LEU F    84                                                      
REMARK 465     GLY F    85                                                      
REMARK 465     THR F    86                                                      
REMARK 465     PRO F    87                                                      
REMARK 465     ARG F    88                                                      
REMARK 465     GLU F    89                                                      
REMARK 465     LYS F    90                                                      
REMARK 465     VAL F    91                                                      
REMARK 465     PRO F    92                                                      
REMARK 465     ALA F    93                                                      
REMARK 465     GLY F    94                                                      
REMARK 465     ARG F    95                                                      
REMARK 465     SER F    96                                                      
REMARK 465     LYS F    97                                                      
REMARK 465     ALA F    98                                                      
REMARK 465     GLU F    99                                                      
REMARK 465     LEU F   100                                                      
REMARK 465     ARG F   101                                                      
REMARK 465     ALA F   102                                                      
REMARK 465     GLU F   103                                                      
REMARK 465     ARG F   104                                                      
REMARK 465     ARG F   105                                                      
REMARK 465     ALA F   106                                                      
REMARK 465     LYS F   107                                                      
REMARK 465     GLN F   108                                                      
REMARK 465     GLU F   109                                                      
REMARK 465     ALA F   110                                                      
REMARK 465     GLU F   111                                                      
REMARK 465     ARG F   112                                                      
REMARK 465     ALA F   113                                                      
REMARK 465     LEU F   114                                                      
REMARK 465     LYS F   115                                                      
REMARK 465     GLN F   116                                                      
REMARK 465     ALA F   117                                                      
REMARK 465     ARG F   118                                                      
REMARK 465     LYS F   119                                                      
REMARK 465     GLY F   120                                                      
REMARK 465     GLU F   121                                                      
REMARK 465     GLN F   122                                                      
REMARK 465     GLY F   123                                                      
REMARK 465     GLY F   124                                                      
REMARK 465     PRO F   125                                                      
REMARK 465     PRO F   126                                                      
REMARK 465     PRO F   127                                                      
REMARK 465     LYS F   128                                                      
REMARK 465     ALA F   129                                                      
REMARK 465     SER F   130                                                      
REMARK 465     PRO F   131                                                      
REMARK 465     SER F   132                                                      
REMARK 465     THR F   133                                                      
REMARK 465     ALA F   134                                                      
REMARK 465     GLY F   135                                                      
REMARK 465     GLU F   136                                                      
REMARK 465     THR F   137                                                      
REMARK 465     PRO F   138                                                      
REMARK 465     SER F   139                                                      
REMARK 465     GLY F   140                                                      
REMARK 465     VAL F   141                                                      
REMARK 465     LYS F   142                                                      
REMARK 465     ARG F   143                                                      
REMARK 465     LEU F   144                                                      
REMARK 465     PRO F   145                                                      
REMARK 465     GLU F   146                                                      
REMARK 465     TYR F   147                                                      
REMARK 465     PRO F   148                                                      
REMARK 465     GLN F   149                                                      
REMARK 465     VAL F   150                                                      
REMARK 465     ASP F   151                                                      
REMARK 465     ASP F   152                                                      
REMARK 465     LEU F   153                                                      
REMARK 465     LEU F   154                                                      
REMARK 465     LEU F   155                                                      
REMARK 465     ARG F   156                                                      
REMARK 465     ARG F   157                                                      
REMARK 465     LEU F   158                                                      
REMARK 465     VAL F   159                                                      
REMARK 465     LYS F   160                                                      
REMARK 465     LYS F   161                                                      
REMARK 465     PRO F   162                                                      
REMARK 465     GLU F   163                                                      
REMARK 465     ARG F   164                                                      
REMARK 465     GLN F   165                                                      
REMARK 465     GLN F   523                                                      
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     PRO A     4                                                      
REMARK 465     VAL A     5                                                      
REMARK 465     VAL A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     PRO A     8                                                      
REMARK 465     PRO A     9                                                      
REMARK 465     GLY A    10                                                      
REMARK 465     VAL A    11                                                      
REMARK 465     VAL A    12                                                      
REMARK 465     VAL A    13                                                      
REMARK 465     SER A    14                                                      
REMARK 465     ARG A    15                                                      
REMARK 465     ALA A    16                                                      
REMARK 465     ASN A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     ARG A    19                                                      
REMARK 465     SER A    20                                                      
REMARK 465     GLY A    21                                                      
REMARK 465     ALA A    22                                                      
REMARK 465     GLY A    23                                                      
REMARK 465     PRO A    24                                                      
REMARK 465     GLY A    25                                                      
REMARK 465     GLY A    26                                                      
REMARK 465     SER A    27                                                      
REMARK 465     GLY A    28                                                      
REMARK 465     GLY A    29                                                      
REMARK 465     GLY A    30                                                      
REMARK 465     GLY A    31                                                      
REMARK 465     ALA A    32                                                      
REMARK 465     ARG A    33                                                      
REMARK 465     GLY A    34                                                      
REMARK 465     ALA A    35                                                      
REMARK 465     GLU A    36                                                      
REMARK 465     GLU A    37                                                      
REMARK 465     GLU A    38                                                      
REMARK 465     PRO A    39                                                      
REMARK 465     PRO A    40                                                      
REMARK 465     GLU A   280                                                      
REMARK 465     GLU A   281                                                      
REMARK 465     ILE A   282                                                      
REMARK 465     LEU A   283                                                      
REMARK 465     GLY A   284                                                      
REMARK 465     ASP A   467                                                      
REMARK 465     ASP A   468                                                      
REMARK 465     SER A   469                                                      
REMARK 465     GLY A   470                                                      
REMARK 465     ALA A   471                                                      
REMARK 465     ASP A   472                                                      
REMARK 465     GLN A   473                                                      
REMARK 465     GLU A   474                                                      
REMARK 465     LYS A   475                                                      
REMARK 465     ASP A   476                                                      
REMARK 465     LYS A   477                                                      
REMARK 465     VAL A   478                                                      
REMARK 465     LYS A   479                                                      
REMARK 465     MET A   480                                                      
REMARK 465     LYS A   481                                                      
REMARK 465     GLY A   482                                                      
REMARK 465     TYR A   483                                                      
REMARK 465     ASN A   484                                                      
REMARK 465     PRO A   485                                                      
REMARK 465     ALA A   486                                                      
REMARK 465     GLU A   487                                                      
REMARK 465     VAL A   488                                                      
REMARK 465     GLY A   489                                                      
REMARK 465     ALA A   490                                                      
REMARK 465     ALA A   491                                                      
REMARK 465     GLY A   492                                                      
REMARK 465     LYS A   493                                                      
REMARK 465     GLY A   494                                                      
REMARK 465     TYR A   495                                                      
REMARK 465     LEU A   496                                                      
REMARK 465     TRP A   497                                                      
REMARK 465     LYS A   498                                                      
REMARK 465     ALA A   499                                                      
REMARK 465     ALA A   500                                                      
REMARK 465     GLY A   501                                                      
REMARK 465     MET A   502                                                      
REMARK 465     ASN A   503                                                      
REMARK 465     MET A   504                                                      
REMARK 465     GLU A   505                                                      
REMARK 465     GLU A   506                                                      
REMARK 465     GLU A   507                                                      
REMARK 465     GLU A   508                                                      
REMARK 465     GLU A   509                                                      
REMARK 465     LEU A   510                                                      
REMARK 465     GLN A   511                                                      
REMARK 465     GLN A   512                                                      
REMARK 465     ASN A   513                                                      
REMARK 465     LEU A   514                                                      
REMARK 465     TRP A   515                                                      
REMARK 465     GLY A   516                                                      
REMARK 465     LEU A   517                                                      
REMARK 465     LYS A   518                                                      
REMARK 465     ILE A   519                                                      
REMARK 465     ASN A   520                                                      
REMARK 465     MET A   521                                                      
REMARK 465     GLU A   522                                                      
REMARK 465     GLU A   523                                                      
REMARK 465     GLU A   524                                                      
REMARK 465     SER A   525                                                      
REMARK 465     GLU A   526                                                      
REMARK 465     SER A   527                                                      
REMARK 465     GLU A   528                                                      
REMARK 465     SER A   529                                                      
REMARK 465     GLU A   530                                                      
REMARK 465     GLN A   531                                                      
REMARK 465     SER A   532                                                      
REMARK 465     MET A   533                                                      
REMARK 465     ASP A   534                                                      
REMARK 465     SER A   535                                                      
REMARK 465     GLU A   536                                                      
REMARK 465     GLU A   537                                                      
REMARK 465     PRO A   538                                                      
REMARK 465     ASP A   539                                                      
REMARK 465     SER A   540                                                      
REMARK 465     ARG A   541                                                      
REMARK 465     GLY A   542                                                      
REMARK 465     GLY A   543                                                      
REMARK 465     SER A   544                                                      
REMARK 465     PRO A   545                                                      
REMARK 465     GLN A   546                                                      
REMARK 465     MET A   547                                                      
REMARK 465     ASP A   548                                                      
REMARK 465     ASP A   549                                                      
REMARK 465     ILE A   550                                                      
REMARK 465     LYS A   551                                                      
REMARK 465     VAL A   552                                                      
REMARK 465     PHE A   553                                                      
REMARK 465     GLN A   554                                                      
REMARK 465     ASN A   555                                                      
REMARK 465     GLU A   556                                                      
REMARK 465     VAL A   557                                                      
REMARK 465     LEU A   558                                                      
REMARK 465     GLY A   559                                                      
REMARK 465     THR A   560                                                      
REMARK 465     LEU A   561                                                      
REMARK 465     GLN A   562                                                      
REMARK 465     ARG A   563                                                      
REMARK 465     GLY A   564                                                      
REMARK 465     LYS A   565                                                      
REMARK 465     GLU A   566                                                      
REMARK 465     GLU A   567                                                      
REMARK 465     ASN A   568                                                      
REMARK 465     ILE A   569                                                      
REMARK 465     SER A   570                                                      
REMARK 465     CYS A   571                                                      
REMARK 465     ASP A   572                                                      
REMARK 465     ASN A   573                                                      
REMARK 465     LEU A   574                                                      
REMARK 465     VAL A   575                                                      
REMARK 465     LEU A   576                                                      
REMARK 465     GLU A   577                                                      
REMARK 465     ILE A   578                                                      
REMARK 465     ASN A   579                                                      
REMARK 465     SER A   580                                                      
REMARK 465     LEU A   581                                                      
REMARK 465     LYS A   582                                                      
REMARK 465     TYR A   583                                                      
REMARK 465     ALA A   584                                                      
REMARK 465     TYR A   585                                                      
REMARK 465     ASN A   586                                                      
REMARK 465     VAL A   587                                                      
REMARK 465     SER A   588                                                      
REMARK 465     LEU A   589                                                      
REMARK 465     LYS A   590                                                      
REMARK 465     GLU A   591                                                      
REMARK 465     VAL A   592                                                      
REMARK 465     MET A   593                                                      
REMARK 465     GLN A   594                                                      
REMARK 465     VAL A   595                                                      
REMARK 465     LEU A   596                                                      
REMARK 465     SER A   597                                                      
REMARK 465     HIS A   598                                                      
REMARK 465     VAL A   599                                                      
REMARK 465     VAL A   600                                                      
REMARK 465     LEU A   601                                                      
REMARK 465     GLU A   602                                                      
REMARK 465     PHE A   603                                                      
REMARK 465     PRO A   604                                                      
REMARK 465     LEU A   605                                                      
REMARK 465     GLN A   606                                                      
REMARK 465     GLN A   607                                                      
REMARK 465     MET A   608                                                      
REMARK 465     ASP A   609                                                      
REMARK 465     SER A   610                                                      
REMARK 465     PRO A   611                                                      
REMARK 465     LEU A   612                                                      
REMARK 465     ASP A   613                                                      
REMARK 465     SER A   614                                                      
REMARK 465     SER A   615                                                      
REMARK 465     ARG A   616                                                      
REMARK 465     TYR A   617                                                      
REMARK 465     CYS A   618                                                      
REMARK 465     ALA A   619                                                      
REMARK 465     LEU A   620                                                      
REMARK 465     LEU A   621                                                      
REMARK 465     LEU A   622                                                      
REMARK 465     PRO A   623                                                      
REMARK 465     LEU A   624                                                      
REMARK 465     LEU A   625                                                      
REMARK 465     LYS A   626                                                      
REMARK 465     ALA A   627                                                      
REMARK 465     TRP A   628                                                      
REMARK 465     SER A   629                                                      
REMARK 465     PRO A   630                                                      
REMARK 465     VAL A   631                                                      
REMARK 465     PHE A   632                                                      
REMARK 465     ARG A   633                                                      
REMARK 465     ASN A   634                                                      
REMARK 465     TYR A   635                                                      
REMARK 465     ILE A   636                                                      
REMARK 465     LYS A   637                                                      
REMARK 465     ARG A   638                                                      
REMARK 465     ALA A   639                                                      
REMARK 465     ALA A   640                                                      
REMARK 465     ASP A   641                                                      
REMARK 465     HIS A   642                                                      
REMARK 465     LEU A   643                                                      
REMARK 465     GLU A   644                                                      
REMARK 465     ALA A   645                                                      
REMARK 465     LEU A   646                                                      
REMARK 465     ALA A   647                                                      
REMARK 465     ALA A   648                                                      
REMARK 465     ILE A   649                                                      
REMARK 465     GLU A   650                                                      
REMARK 465     ASP A   651                                                      
REMARK 465     PHE A   652                                                      
REMARK 465     PHE A   653                                                      
REMARK 465     LEU A   654                                                      
REMARK 465     GLU A   655                                                      
REMARK 465     HIS A   656                                                      
REMARK 465     GLU A   657                                                      
REMARK 465     ALA A   658                                                      
REMARK 465     LEU A   659                                                      
REMARK 465     GLY A   660                                                      
REMARK 465     ILE A   661                                                      
REMARK 465     SER A   662                                                      
REMARK 465     MET A   663                                                      
REMARK 465     ALA A   664                                                      
REMARK 465     LYS A   665                                                      
REMARK 465     VAL A   666                                                      
REMARK 465     LEU A   667                                                      
REMARK 465     MET A   668                                                      
REMARK 465     ALA A   669                                                      
REMARK 465     PHE A   670                                                      
REMARK 465     TYR A   671                                                      
REMARK 465     GLN A   672                                                      
REMARK 465     LEU A   673                                                      
REMARK 465     GLU A   674                                                      
REMARK 465     ILE A   675                                                      
REMARK 465     LEU A   676                                                      
REMARK 465     ALA A   677                                                      
REMARK 465     GLU A   678                                                      
REMARK 465     GLU A   679                                                      
REMARK 465     THR A   680                                                      
REMARK 465     ILE A   681                                                      
REMARK 465     LEU A   682                                                      
REMARK 465     SER A   683                                                      
REMARK 465     TRP A   684                                                      
REMARK 465     PHE A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     GLN A   687                                                      
REMARK 465     ARG A   688                                                      
REMARK 465     ASP A   689                                                      
REMARK 465     THR A   690                                                      
REMARK 465     THR A   691                                                      
REMARK 465     ASP A   692                                                      
REMARK 465     LYS A   693                                                      
REMARK 465     GLY A   694                                                      
REMARK 465     GLN A   695                                                      
REMARK 465     GLN A   696                                                      
REMARK 465     LEU A   697                                                      
REMARK 465     ARG A   698                                                      
REMARK 465     LYS A   699                                                      
REMARK 465     ASN A   700                                                      
REMARK 465     GLN A   701                                                      
REMARK 465     GLN A   702                                                      
REMARK 465     LEU A   703                                                      
REMARK 465     GLN A   704                                                      
REMARK 465     ARG A   705                                                      
REMARK 465     PHE A   706                                                      
REMARK 465     ILE A   707                                                      
REMARK 465     GLN A   708                                                      
REMARK 465     TRP A   709                                                      
REMARK 465     LEU A   710                                                      
REMARK 465     LYS A   711                                                      
REMARK 465     GLU A   712                                                      
REMARK 465     ALA A   713                                                      
REMARK 465     GLU A   714                                                      
REMARK 465     GLU A   715                                                      
REMARK 465     GLU A   716                                                      
REMARK 465     SER A   717                                                      
REMARK 465     SER A   718                                                      
REMARK 465     GLU A   719                                                      
REMARK 465     ASP A   720                                                      
REMARK 465     ASP A   721                                                      
REMARK 465     GLY I    13                                                      
REMARK 465     SER I    14                                                      
REMARK 465     ARG I    15                                                      
REMARK 465     MET I    16                                                      
REMARK 465     THR I    17                                                      
REMARK 465     ASP I    18                                                      
REMARK 465     LEU I    19                                                      
REMARK 465     THR I    20                                                      
REMARK 465     GLY I   135                                                      
REMARK 465     GLN I   136                                                      
REMARK 465     ASP I   137                                                      
REMARK 465     SER I   138                                                      
REMARK 465     ILE I   139                                                      
REMARK 465     GLU I   140                                                      
REMARK 465     PRO I   141                                                      
REMARK 465     VAL I   142                                                      
REMARK 465     PRO I   143                                                      
REMARK 465     GLY I   144                                                      
REMARK 465     GLN I   145                                                      
REMARK 465     LYS I   146                                                      
REMARK 465     GLY I   147                                                      
REMARK 465     LYS I   148                                                      
REMARK 465     LYS I   149                                                      
REMARK 465     LYS I   150                                                      
REMARK 465     ALA I   151                                                      
REMARK 465     VAL I   152                                                      
REMARK 465     GLU I   153                                                      
REMARK 465     GLN I   154                                                      
REMARK 465     PHE I   237                                                      
REMARK 465     SER I   238                                                      
REMARK 465     GLN I   244                                                      
REMARK 465     GLY I   245                                                      
REMARK 465     GLN I   246                                                      
REMARK 465     GLU I   247                                                      
REMARK 465     GLU I   248                                                      
REMARK 465     LYS I   249                                                      
REMARK 465     GLU I   250                                                      
REMARK 465     GLU I   251                                                      
REMARK 465     ASP I   252                                                      
REMARK 465     LEU I   253                                                      
REMARK 465     LYS I   254                                                      
REMARK 465     LYS I   255                                                      
REMARK 465     LYS I   256                                                      
REMARK 465     GLU I   257                                                      
REMARK 465     LYS I   268                                                      
REMARK 465     GLU I   269                                                      
REMARK 465     ALA I   270                                                      
REMARK 465     ASN I   271                                                      
REMARK 465     LEU I   293                                                      
REMARK 465     SER I   294                                                      
REMARK 465     ARG I   295                                                      
REMARK 465     SER I   296                                                      
REMARK 465     GLN I   297                                                      
REMARK 465     VAL I   298                                                      
REMARK 465     ARG I   299                                                      
REMARK 465     CYS I   300                                                      
REMARK 465     TYR I   301                                                      
REMARK 465     VAL I   302                                                      
REMARK 465     HIS I   303                                                      
REMARK 465     ILE I   304                                                      
REMARK 465     MET I   305                                                      
REMARK 465     LYS I   306                                                      
REMARK 465     GLU I   307                                                      
REMARK 465     GLY I   308                                                      
REMARK 465     LEU I   309                                                      
REMARK 465     CYS I   310                                                      
REMARK 465     SER I   311                                                      
REMARK 465     ARG I   312                                                      
REMARK 465     VAL I   313                                                      
REMARK 465     SER I   314                                                      
REMARK 465     THR I   315                                                      
REMARK 465     LEU I   316                                                      
REMARK 465     GLY I   317                                                      
REMARK 465     LEU I   318                                                      
REMARK 465     TYR I   319                                                      
REMARK 465     MET I   320                                                      
REMARK 465     GLU I   321                                                      
REMARK 465     ALA I   322                                                      
REMARK 465     ASN I   323                                                      
REMARK 465     ARG I   324                                                      
REMARK 465     GLN I   325                                                      
REMARK 465     VAL I   326                                                      
REMARK 465     PRO I   327                                                      
REMARK 465     LYS I   328                                                      
REMARK 465     LEU I   329                                                      
REMARK 465     LEU I   330                                                      
REMARK 465     SER I   331                                                      
REMARK 465     ALA I   332                                                      
REMARK 465     LEU I   333                                                      
REMARK 465     CYS I   334                                                      
REMARK 465     PRO I   335                                                      
REMARK 465     GLU I   336                                                      
REMARK 465     GLU I   337                                                      
REMARK 465     PRO I   338                                                      
REMARK 465     PRO I   339                                                      
REMARK 465     VAL I   340                                                      
REMARK 465     HIS I   341                                                      
REMARK 465     SER I   342                                                      
REMARK 465     SER I   343                                                      
REMARK 465     ALA I   344                                                      
REMARK 465     GLN I   345                                                      
REMARK 465     ILE I   346                                                      
REMARK 465     VAL I   347                                                      
REMARK 465     SER I   348                                                      
REMARK 465     LYS I   349                                                      
REMARK 465     HIS I   350                                                      
REMARK 465     LEU I   351                                                      
REMARK 465     VAL I   352                                                      
REMARK 465     GLY I   353                                                      
REMARK 465     VAL I   354                                                      
REMARK 465     ASP I   355                                                      
REMARK 465     SER I   356                                                      
REMARK 465     LEU I   357                                                      
REMARK 465     ILE I   358                                                      
REMARK 465     GLY I   359                                                      
REMARK 465     PRO I   360                                                      
REMARK 465     GLU I   361                                                      
REMARK 465     THR I   362                                                      
REMARK 465     GLN I   363                                                      
REMARK 465     ILE I   364                                                      
REMARK 465     GLY I   365                                                      
REMARK 465     GLU I   366                                                      
REMARK 465     LYS I   367                                                      
REMARK 465     SER I   368                                                      
REMARK 465     SER I   369                                                      
REMARK 465     ILE I   370                                                      
REMARK 465     LYS I   371                                                      
REMARK 465     ARG I   372                                                      
REMARK 465     SER I   373                                                      
REMARK 465     VAL I   374                                                      
REMARK 465     ILE I   375                                                      
REMARK 465     GLY I   376                                                      
REMARK 465     SER I   377                                                      
REMARK 465     SER I   378                                                      
REMARK 465     CYS I   379                                                      
REMARK 465     LEU I   380                                                      
REMARK 465     ILE I   381                                                      
REMARK 465     LYS I   382                                                      
REMARK 465     ASP I   383                                                      
REMARK 465     ARG I   384                                                      
REMARK 465     VAL I   385                                                      
REMARK 465     THR I   386                                                      
REMARK 465     ILE I   387                                                      
REMARK 465     THR I   388                                                      
REMARK 465     ASN I   389                                                      
REMARK 465     CYS I   390                                                      
REMARK 465     LEU I   391                                                      
REMARK 465     LEU I   392                                                      
REMARK 465     MET I   393                                                      
REMARK 465     ASN I   394                                                      
REMARK 465     SER I   395                                                      
REMARK 465     VAL I   396                                                      
REMARK 465     THR I   397                                                      
REMARK 465     VAL I   398                                                      
REMARK 465     GLU I   399                                                      
REMARK 465     GLU I   400                                                      
REMARK 465     GLY I   401                                                      
REMARK 465     SER I   402                                                      
REMARK 465     ASN I   403                                                      
REMARK 465     ILE I   404                                                      
REMARK 465     GLN I   405                                                      
REMARK 465     GLY I   406                                                      
REMARK 465     SER I   407                                                      
REMARK 465     VAL I   408                                                      
REMARK 465     ILE I   409                                                      
REMARK 465     CYS I   410                                                      
REMARK 465     ASN I   411                                                      
REMARK 465     ASN I   412                                                      
REMARK 465     ALA I   413                                                      
REMARK 465     VAL I   414                                                      
REMARK 465     ILE I   415                                                      
REMARK 465     GLU I   416                                                      
REMARK 465     LYS I   417                                                      
REMARK 465     GLY I   418                                                      
REMARK 465     ALA I   419                                                      
REMARK 465     ASP I   420                                                      
REMARK 465     ILE I   421                                                      
REMARK 465     LYS I   422                                                      
REMARK 465     ASP I   423                                                      
REMARK 465     CYS I   424                                                      
REMARK 465     LEU I   425                                                      
REMARK 465     ILE I   426                                                      
REMARK 465     GLY I   427                                                      
REMARK 465     SER I   428                                                      
REMARK 465     GLY I   429                                                      
REMARK 465     GLN I   430                                                      
REMARK 465     ARG I   431                                                      
REMARK 465     ILE I   432                                                      
REMARK 465     GLU I   433                                                      
REMARK 465     ALA I   434                                                      
REMARK 465     LYS I   435                                                      
REMARK 465     ALA I   436                                                      
REMARK 465     LYS I   437                                                      
REMARK 465     ARG I   438                                                      
REMARK 465     VAL I   439                                                      
REMARK 465     ASN I   440                                                      
REMARK 465     GLU I   441                                                      
REMARK 465     VAL I   442                                                      
REMARK 465     ILE I   443                                                      
REMARK 465     VAL I   444                                                      
REMARK 465     GLY I   445                                                      
REMARK 465     ASN I   446                                                      
REMARK 465     ASP I   447                                                      
REMARK 465     GLN I   448                                                      
REMARK 465     LEU I   449                                                      
REMARK 465     MET I   450                                                      
REMARK 465     GLU I   451                                                      
REMARK 465     ILE I   452                                                      
REMARK 465     MET G     1                                                      
REMARK 465     ASP G     2                                                      
REMARK 465     ASP G     3                                                      
REMARK 465     ASP G    37                                                      
REMARK 465     LYS G    38                                                      
REMARK 465     GLY G    39                                                      
REMARK 465     GLU G    40                                                      
REMARK 465     THR G    41                                                      
REMARK 465     ILE G    42                                                      
REMARK 465     GLN G    43                                                      
REMARK 465     LEU G    78                                                      
REMARK 465     ALA G    79                                                      
REMARK 465     SER G    80                                                      
REMARK 465     LEU G    81                                                      
REMARK 465     GLU G    82                                                      
REMARK 465     TYR G    83                                                      
REMARK 465     SER G    84                                                      
REMARK 465     ASP G    85                                                      
REMARK 465     TYR G    86                                                      
REMARK 465     SER G    87                                                      
REMARK 465     LYS G    88                                                      
REMARK 465     CYS G    89                                                      
REMARK 465     LYS G    90                                                      
REMARK 465     LYS G   253                                                      
REMARK 465     ALA G   254                                                      
REMARK 465     ASP G   255                                                      
REMARK 465     THR G   256                                                      
REMARK 465     LEU G   257                                                      
REMARK 465     LYS G   258                                                      
REMARK 465     VAL G   259                                                      
REMARK 465     ALA G   260                                                      
REMARK 465     GLN G   261                                                      
REMARK 465     THR G   262                                                      
REMARK 465     GLY G   263                                                      
REMARK 465     GLN G   264                                                      
REMARK 465     ASP G   265                                                      
REMARK 465     LEU G   266                                                      
REMARK 465     LYS G   267                                                      
REMARK 465     GLU G   268                                                      
REMARK 465     GLU G   269                                                      
REMARK 465     MET D   -16                                                      
REMARK 465     HIS D   -15                                                      
REMARK 465     HIS D   -14                                                      
REMARK 465     HIS D   -13                                                      
REMARK 465     HIS D   -12                                                      
REMARK 465     HIS D   -11                                                      
REMARK 465     HIS D   -10                                                      
REMARK 465     GLY D    -9                                                      
REMARK 465     GLY D    -8                                                      
REMARK 465     GLY D    -7                                                      
REMARK 465     SER D    -6                                                      
REMARK 465     GLU D    -5                                                      
REMARK 465     ASN D    -4                                                      
REMARK 465     LEU D    -3                                                      
REMARK 465     TYR D    -2                                                      
REMARK 465     PHE D    -1                                                      
REMARK 465     GLN D     0                                                      
REMARK 465     SER D     1                                                      
REMARK 465     PRO D     2                                                      
REMARK 465     GLY D     3                                                      
REMARK 465     SER D     4                                                      
REMARK 465     ALA D     5                                                      
REMARK 465     ALA D     6                                                      
REMARK 465     LYS D     7                                                      
REMARK 465     ARG D    99                                                      
REMARK 465     SER D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     GLU D   102                                                      
REMARK 465     SER D   103                                                      
REMARK 465     ASP D   104                                                      
REMARK 465     GLN D   105                                                      
REMARK 465     GLN D   106                                                      
REMARK 465     GLU D   107                                                      
REMARK 465     SER D   108                                                      
REMARK 465     LEU D   109                                                      
REMARK 465     HIS D   110                                                      
REMARK 465     LYS D   111                                                      
REMARK 465     LEU D   112                                                      
REMARK 465     LEU D   113                                                      
REMARK 465     THR D   114                                                      
REMARK 465     SER D   115                                                      
REMARK 465     GLY D   116                                                      
REMARK 465     GLY D   117                                                      
REMARK 465     LEU D   118                                                      
REMARK 465     ASN D   119                                                      
REMARK 465     GLU D   120                                                      
REMARK 465     ASP D   121                                                      
REMARK 465     PHE D   122                                                      
REMARK 465     SER D   123                                                      
REMARK 465     PHE D   124                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     VAL E     4                                                      
REMARK 465     ALA E     5                                                      
REMARK 465     VAL E     6                                                      
REMARK 465     ALA E     7                                                      
REMARK 465     VAL E     8                                                      
REMARK 465     ARG E     9                                                      
REMARK 465     GLU E    10                                                      
REMARK 465     ASP E    11                                                      
REMARK 465     SER E    12                                                      
REMARK 465     GLY E    13                                                      
REMARK 465     SER E    14                                                      
REMARK 465     GLY E    15                                                      
REMARK 465     MET E    16                                                      
REMARK 465     LYS E    17                                                      
REMARK 465     ALA E    18                                                      
REMARK 465     GLU E    19                                                      
REMARK 465     LEU E    20                                                      
REMARK 465     PRO E    21                                                      
REMARK 465     PRO E    22                                                      
REMARK 465     GLY E    23                                                      
REMARK 465     PRO E    24                                                      
REMARK 465     GLY E    25                                                      
REMARK 465     ALA E    26                                                      
REMARK 465     VAL E    27                                                      
REMARK 465     GLY E    28                                                      
REMARK 465     ARG E    29                                                      
REMARK 465     GLU E    30                                                      
REMARK 465     MET E    31                                                      
REMARK 465     THR E    32                                                      
REMARK 465     LYS E    33                                                      
REMARK 465     GLU E    34                                                      
REMARK 465     GLU E    35                                                      
REMARK 465     LYS E    36                                                      
REMARK 465     LEU E    37                                                      
REMARK 465     GLN E    38                                                      
REMARK 465     LEU E    39                                                      
REMARK 465     ARG E    40                                                      
REMARK 465     LYS E    41                                                      
REMARK 465     GLU E    42                                                      
REMARK 465     LYS E    43                                                      
REMARK 465     LYS E    44                                                      
REMARK 465     GLN E    45                                                      
REMARK 465     GLN E    46                                                      
REMARK 465     LYS E    47                                                      
REMARK 465     LYS E    48                                                      
REMARK 465     LYS E    49                                                      
REMARK 465     ARG E    50                                                      
REMARK 465     LYS E    51                                                      
REMARK 465     GLU E    52                                                      
REMARK 465     GLU E    53                                                      
REMARK 465     LYS E    54                                                      
REMARK 465     GLY E    55                                                      
REMARK 465     ALA E    56                                                      
REMARK 465     GLU E    57                                                      
REMARK 465     PRO E    58                                                      
REMARK 465     GLU E    59                                                      
REMARK 465     THR E    60                                                      
REMARK 465     GLY E    61                                                      
REMARK 465     SER E    62                                                      
REMARK 465     ALA E    63                                                      
REMARK 465     VAL E    64                                                      
REMARK 465     SER E    65                                                      
REMARK 465     ALA E    66                                                      
REMARK 465     ALA E    67                                                      
REMARK 465     GLN E    68                                                      
REMARK 465     CYS E    69                                                      
REMARK 465     GLN E    70                                                      
REMARK 465     VAL E    71                                                      
REMARK 465     GLY E    72                                                      
REMARK 465     PRO E    73                                                      
REMARK 465     THR E    74                                                      
REMARK 465     ARG E    75                                                      
REMARK 465     GLU E    76                                                      
REMARK 465     LEU E    77                                                      
REMARK 465     PRO E    78                                                      
REMARK 465     GLU E    79                                                      
REMARK 465     SER E    80                                                      
REMARK 465     GLY E    81                                                      
REMARK 465     ILE E    82                                                      
REMARK 465     GLN E    83                                                      
REMARK 465     LEU E    84                                                      
REMARK 465     GLY E    85                                                      
REMARK 465     THR E    86                                                      
REMARK 465     PRO E    87                                                      
REMARK 465     ARG E    88                                                      
REMARK 465     GLU E    89                                                      
REMARK 465     LYS E    90                                                      
REMARK 465     VAL E    91                                                      
REMARK 465     PRO E    92                                                      
REMARK 465     ALA E    93                                                      
REMARK 465     GLY E    94                                                      
REMARK 465     ARG E    95                                                      
REMARK 465     SER E    96                                                      
REMARK 465     LYS E    97                                                      
REMARK 465     ALA E    98                                                      
REMARK 465     GLU E    99                                                      
REMARK 465     LEU E   100                                                      
REMARK 465     ARG E   101                                                      
REMARK 465     ALA E   102                                                      
REMARK 465     GLU E   103                                                      
REMARK 465     ARG E   104                                                      
REMARK 465     ARG E   105                                                      
REMARK 465     ALA E   106                                                      
REMARK 465     LYS E   107                                                      
REMARK 465     GLN E   108                                                      
REMARK 465     GLU E   109                                                      
REMARK 465     ALA E   110                                                      
REMARK 465     GLU E   111                                                      
REMARK 465     ARG E   112                                                      
REMARK 465     ALA E   113                                                      
REMARK 465     LEU E   114                                                      
REMARK 465     LYS E   115                                                      
REMARK 465     GLN E   116                                                      
REMARK 465     ALA E   117                                                      
REMARK 465     ARG E   118                                                      
REMARK 465     LYS E   119                                                      
REMARK 465     GLY E   120                                                      
REMARK 465     GLU E   121                                                      
REMARK 465     GLN E   122                                                      
REMARK 465     GLY E   123                                                      
REMARK 465     GLY E   124                                                      
REMARK 465     PRO E   125                                                      
REMARK 465     PRO E   126                                                      
REMARK 465     PRO E   127                                                      
REMARK 465     LYS E   128                                                      
REMARK 465     ALA E   129                                                      
REMARK 465     SER E   130                                                      
REMARK 465     PRO E   131                                                      
REMARK 465     SER E   132                                                      
REMARK 465     THR E   133                                                      
REMARK 465     ALA E   134                                                      
REMARK 465     GLY E   135                                                      
REMARK 465     GLU E   136                                                      
REMARK 465     THR E   137                                                      
REMARK 465     PRO E   138                                                      
REMARK 465     SER E   139                                                      
REMARK 465     GLY E   140                                                      
REMARK 465     VAL E   141                                                      
REMARK 465     LYS E   142                                                      
REMARK 465     ARG E   143                                                      
REMARK 465     LEU E   144                                                      
REMARK 465     PRO E   145                                                      
REMARK 465     GLU E   146                                                      
REMARK 465     TYR E   147                                                      
REMARK 465     PRO E   148                                                      
REMARK 465     GLN E   149                                                      
REMARK 465     VAL E   150                                                      
REMARK 465     ASP E   151                                                      
REMARK 465     ASP E   152                                                      
REMARK 465     LEU E   153                                                      
REMARK 465     LEU E   154                                                      
REMARK 465     LEU E   155                                                      
REMARK 465     ARG E   156                                                      
REMARK 465     ARG E   157                                                      
REMARK 465     LEU E   158                                                      
REMARK 465     VAL E   159                                                      
REMARK 465     LYS E   160                                                      
REMARK 465     LYS E   161                                                      
REMARK 465     PRO E   162                                                      
REMARK 465     GLU E   163                                                      
REMARK 465     ARG E   164                                                      
REMARK 465     GLN E   165                                                      
REMARK 465     GLN E   523                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU B 126    CG   CD   OE1  OE2                                  
REMARK 470     LEU B 127    CG   CD1  CD2                                       
REMARK 470     ARG B 129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B 176    CG   CD   CE   NZ                                   
REMARK 470     ASN B 177    CG   OD1  ND2                                       
REMARK 470     VAL B 178    CG1  CG2                                            
REMARK 470     GLN B 219    CG   CD   OE1  NE2                                  
REMARK 470     LEU B 221    CG   CD1  CD2                                       
REMARK 470     ARG B 222    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 223    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER B 229    OG                                                  
REMARK 470     GLN B 232    CG   CD   OE1  NE2                                  
REMARK 470     SER B 234    OG                                                  
REMARK 470     SER B 235    OG                                                  
REMARK 470     ASP B 236    CG   OD1  OD2                                       
REMARK 470     ASN B 279    CG   OD1  ND2                                       
REMARK 470     LYS B 294    CG   CD   CE   NZ                                   
REMARK 470     GLU B 347    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 421    CG   CD   OE1  OE2                                  
REMARK 470     ARG B 422    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN B 434    CG   CD   OE1  NE2                                  
REMARK 470     ASN B 440    CG   OD1  ND2                                       
REMARK 470     ILE B 441    CG1  CG2  CD1                                       
REMARK 470     GLU B 445    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 455    CG   OD1  OD2                                       
REMARK 470     GLU B 457    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 458    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 460    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 461    CG   OD1  OD2                                       
REMARK 470     ASP B 462    CG   OD1  OD2                                       
REMARK 470     GLU B 464    CG   CD   OE1  OE2                                  
REMARK 470     SER J  21    OG                                                  
REMARK 470     SER J  22    OG                                                  
REMARK 470     ILE J  23    CG1  CG2  CD1                                       
REMARK 470     LYS J  25    CG   CD   CE   NZ                                   
REMARK 470     LEU J  28    CG   CD1  CD2                                       
REMARK 470     PRO J  29    CG   CD                                             
REMARK 470     VAL J  30    CG1  CG2                                            
REMARK 470     ASN J  32    CG   OD1  ND2                                       
REMARK 470     LYS J  33    CG   CD   CE   NZ                                   
REMARK 470     PRO J  34    CG   CD                                             
REMARK 470     LEU J  35    CG   CD1  CD2                                       
REMARK 470     THR J  55    OG1  CG2                                            
REMARK 470     THR J  56    OG1  CG2                                            
REMARK 470     ARG J  57    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP J  58    CG   OD1  OD2                                       
REMARK 470     VAL J  59    CG1  CG2                                            
REMARK 470     LYS J  61    CG   CD   CE   NZ                                   
REMARK 470     LEU J  63    CG   CD1  CD2                                       
REMARK 470     CYS J  64    SG                                                  
REMARK 470     GLU J  66    CG   CD   OE1  OE2                                  
REMARK 470     PHE J  67    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS J  68    CG   CD   CE   NZ                                   
REMARK 470     MET J  69    CG   SD   CE                                        
REMARK 470     LYS J  70    CG   CD   CE   NZ                                   
REMARK 470     MET J  71    CG   SD   CE                                        
REMARK 470     LYS J  72    CG   CD   CE   NZ                                   
REMARK 470     ASP J  80    CG   OD1  OD2                                       
REMARK 470     ASP J  81    CG   OD1  OD2                                       
REMARK 470     ASP J  83    CG   OD1  OD2                                       
REMARK 470     MET J  84    CG   SD   CE                                        
REMARK 470     ASP J 107    CG   OD1  OD2                                       
REMARK 470     LEU J 108    CG   CD1  CD2                                       
REMARK 470     ASP J 175    CG   OD1  OD2                                       
REMARK 470     ASP J 177    CG   OD1  OD2                                       
REMARK 470     GLU J 178    CG   CD   OE1  OE2                                  
REMARK 470     SER J 223    OG                                                  
REMARK 470     LYS J 235    CG   CD   CE   NZ                                   
REMARK 470     GLN J 236    CG   CD   OE1  NE2                                  
REMARK 470     LEU J 258    CG   CD1  CD2                                       
REMARK 470     LYS J 259    CG   CD   CE   NZ                                   
REMARK 470     SER J 260    OG                                                  
REMARK 470     LEU J 273    CG   CD1  CD2                                       
REMARK 470     ASN J 274    CG   OD1  ND2                                       
REMARK 470     LEU J 275    CG   CD1  CD2                                       
REMARK 470     PRO J 277    CG   CD                                             
REMARK 470     ASP J 279    CG   OD1  OD2                                       
REMARK 470     CYS J 281    SG                                                  
REMARK 470     TRP J 282    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP J 282    CZ3  CH2                                            
REMARK 470     ASN J 283    CG   OD1  ND2                                       
REMARK 470     CYS J 285    SG                                                  
REMARK 470     ARG J 286    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP J 288    CG   OD1  OD2                                       
REMARK 470     ARG J 289    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP J 290    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP J 290    CZ3  CH2                                            
REMARK 470     GLU J 291    CG   CD   OE1  OE2                                  
REMARK 470     ASP J 292    CG   OD1  OD2                                       
REMARK 470     LYS H   4    CG   CD   CE   NZ                                   
REMARK 470     GLU H   5    CG   CD   OE1  OE2                                  
REMARK 470     LEU H   6    CG   CD1  CD2                                       
REMARK 470     ILE H   7    CG1  CG2  CD1                                       
REMARK 470     GLU H   8    CG   CD   OE1  OE2                                  
REMARK 470     SER H  12    OG                                                  
REMARK 470     MET H  14    CG   SD   CE                                        
REMARK 470     LYS H  15    CG   CD   CE   NZ                                   
REMARK 470     GLU H  16    CG   CD   OE1  OE2                                  
REMARK 470     GLU H  32    CG   CD   OE1  OE2                                  
REMARK 470     PHE H  33    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU H  34    CG   CD1  CD2                                       
REMARK 470     LEU H  45    CG   CD1  CD2                                       
REMARK 470     ARG H  46    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN H  48    CG   OD1  ND2                                       
REMARK 470     LEU H  49    CG   CD1  CD2                                       
REMARK 470     THR H  50    OG1  CG2                                            
REMARK 470     SER H  51    OG                                                  
REMARK 470     THR H  55    OG1  CG2                                            
REMARK 470     LEU H  56    CG   CD1  CD2                                       
REMARK 470     CYS H  57    SG                                                  
REMARK 470     VAL H  59    CG1  CG2                                            
REMARK 470     ASP H  60    CG   OD1  OD2                                       
REMARK 470     LEU H  73    CG   CD1  CD2                                       
REMARK 470     PHE H  75    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ILE H  76    CG1  CG2  CD1                                       
REMARK 470     LYS H  91    CG   CD   CE   NZ                                   
REMARK 470     ILE H  92    CG1  CG2  CD1                                       
REMARK 470     ILE H  94    CG1  CG2  CD1                                       
REMARK 470     GLU H  95    CG   CD   OE1  OE2                                  
REMARK 470     ARG H  96    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H  98    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS H 110    CG   CD   CE   NZ                                   
REMARK 470     ARG H 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS H 145    CG   CD   CE   NZ                                   
REMARK 470     ARG H 147    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN H 172    CG   OD1  ND2                                       
REMARK 470     VAL H 173    CG1  CG2                                            
REMARK 470     ASN C 280    CG   OD1  ND2                                       
REMARK 470     GLU C 281    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 282    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 283    CG   OD1  OD2                                       
REMARK 470     ASP F 522    CG   OD1  OD2                                       
REMARK 470     GLU A 126    CG   CD   OE1  OE2                                  
REMARK 470     LEU A 127    CG   CD1  CD2                                       
REMARK 470     ARG A 129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 176    CG   CD   CE   NZ                                   
REMARK 470     ASN A 177    CG   OD1  ND2                                       
REMARK 470     VAL A 178    CG1  CG2                                            
REMARK 470     GLN A 219    CG   CD   OE1  NE2                                  
REMARK 470     LEU A 221    CG   CD1  CD2                                       
REMARK 470     ARG A 222    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 223    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER A 229    OG                                                  
REMARK 470     GLN A 232    CG   CD   OE1  NE2                                  
REMARK 470     SER A 234    OG                                                  
REMARK 470     SER A 235    OG                                                  
REMARK 470     ASP A 236    CG   OD1  OD2                                       
REMARK 470     ASN A 279    CG   OD1  ND2                                       
REMARK 470     LYS A 294    CG   CD   CE   NZ                                   
REMARK 470     GLU A 347    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 421    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 422    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN A 434    CG   CD   OE1  NE2                                  
REMARK 470     ASN A 440    CG   OD1  ND2                                       
REMARK 470     ILE A 441    CG1  CG2  CD1                                       
REMARK 470     GLU A 445    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 455    CG   OD1  OD2                                       
REMARK 470     GLU A 457    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 458    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 460    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 461    CG   OD1  OD2                                       
REMARK 470     ASP A 462    CG   OD1  OD2                                       
REMARK 470     GLU A 464    CG   CD   OE1  OE2                                  
REMARK 470     SER I  21    OG                                                  
REMARK 470     SER I  22    OG                                                  
REMARK 470     ILE I  23    CG1  CG2  CD1                                       
REMARK 470     LYS I  25    CG   CD   CE   NZ                                   
REMARK 470     LEU I  28    CG   CD1  CD2                                       
REMARK 470     PRO I  29    CG   CD                                             
REMARK 470     VAL I  30    CG1  CG2                                            
REMARK 470     ASN I  32    CG   OD1  ND2                                       
REMARK 470     LYS I  33    CG   CD   CE   NZ                                   
REMARK 470     PRO I  34    CG   CD                                             
REMARK 470     LEU I  35    CG   CD1  CD2                                       
REMARK 470     THR I  55    OG1  CG2                                            
REMARK 470     THR I  56    OG1  CG2                                            
REMARK 470     ARG I  57    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP I  58    CG   OD1  OD2                                       
REMARK 470     VAL I  59    CG1  CG2                                            
REMARK 470     LYS I  61    CG   CD   CE   NZ                                   
REMARK 470     LEU I  63    CG   CD1  CD2                                       
REMARK 470     CYS I  64    SG                                                  
REMARK 470     GLU I  66    CG   CD   OE1  OE2                                  
REMARK 470     PHE I  67    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS I  68    CG   CD   CE   NZ                                   
REMARK 470     MET I  69    CG   SD   CE                                        
REMARK 470     LYS I  70    CG   CD   CE   NZ                                   
REMARK 470     MET I  71    CG   SD   CE                                        
REMARK 470     LYS I  72    CG   CD   CE   NZ                                   
REMARK 470     ASP I  80    CG   OD1  OD2                                       
REMARK 470     ASP I  81    CG   OD1  OD2                                       
REMARK 470     ASP I  83    CG   OD1  OD2                                       
REMARK 470     MET I  84    CG   SD   CE                                        
REMARK 470     ASP I 107    CG   OD1  OD2                                       
REMARK 470     LEU I 108    CG   CD1  CD2                                       
REMARK 470     ASP I 175    CG   OD1  OD2                                       
REMARK 470     ASP I 177    CG   OD1  OD2                                       
REMARK 470     GLU I 178    CG   CD   OE1  OE2                                  
REMARK 470     SER I 223    OG                                                  
REMARK 470     LYS I 235    CG   CD   CE   NZ                                   
REMARK 470     GLN I 236    CG   CD   OE1  NE2                                  
REMARK 470     LEU I 258    CG   CD1  CD2                                       
REMARK 470     LYS I 259    CG   CD   CE   NZ                                   
REMARK 470     SER I 260    OG                                                  
REMARK 470     LEU I 273    CG   CD1  CD2                                       
REMARK 470     ASN I 274    CG   OD1  ND2                                       
REMARK 470     LEU I 275    CG   CD1  CD2                                       
REMARK 470     PRO I 277    CG   CD                                             
REMARK 470     ASP I 279    CG   OD1  OD2                                       
REMARK 470     CYS I 281    SG                                                  
REMARK 470     TRP I 282    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP I 282    CZ3  CH2                                            
REMARK 470     ASN I 283    CG   OD1  ND2                                       
REMARK 470     CYS I 285    SG                                                  
REMARK 470     ARG I 286    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP I 288    CG   OD1  OD2                                       
REMARK 470     ARG I 289    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP I 290    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP I 290    CZ3  CH2                                            
REMARK 470     GLU I 291    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 292    CG   OD1  OD2                                       
REMARK 470     LYS G   4    CG   CD   CE   NZ                                   
REMARK 470     GLU G   5    CG   CD   OE1  OE2                                  
REMARK 470     LEU G   6    CG   CD1  CD2                                       
REMARK 470     ILE G   7    CG1  CG2  CD1                                       
REMARK 470     GLU G   8    CG   CD   OE1  OE2                                  
REMARK 470     SER G  12    OG                                                  
REMARK 470     MET G  14    CG   SD   CE                                        
REMARK 470     LYS G  15    CG   CD   CE   NZ                                   
REMARK 470     GLU G  16    CG   CD   OE1  OE2                                  
REMARK 470     GLU G  32    CG   CD   OE1  OE2                                  
REMARK 470     PHE G  33    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU G  34    CG   CD1  CD2                                       
REMARK 470     LEU G  45    CG   CD1  CD2                                       
REMARK 470     ARG G  46    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN G  48    CG   OD1  ND2                                       
REMARK 470     LEU G  49    CG   CD1  CD2                                       
REMARK 470     THR G  50    OG1  CG2                                            
REMARK 470     SER G  51    OG                                                  
REMARK 470     THR G  55    OG1  CG2                                            
REMARK 470     LEU G  56    CG   CD1  CD2                                       
REMARK 470     CYS G  57    SG                                                  
REMARK 470     VAL G  59    CG1  CG2                                            
REMARK 470     ASP G  60    CG   OD1  OD2                                       
REMARK 470     LEU G  73    CG   CD1  CD2                                       
REMARK 470     PHE G  75    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ILE G  76    CG1  CG2  CD1                                       
REMARK 470     LYS G  91    CG   CD   CE   NZ                                   
REMARK 470     ILE G  92    CG1  CG2  CD1                                       
REMARK 470     ILE G  94    CG1  CG2  CD1                                       
REMARK 470     GLU G  95    CG   CD   OE1  OE2                                  
REMARK 470     ARG G  96    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G  98    CG   CD   OE1  OE2                                  
REMARK 470     ARG G 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G 110    CG   CD   CE   NZ                                   
REMARK 470     ARG G 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G 145    CG   CD   CE   NZ                                   
REMARK 470     ARG G 147    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN G 172    CG   OD1  ND2                                       
REMARK 470     VAL G 173    CG1  CG2                                            
REMARK 470     ASN D 280    CG   OD1  ND2                                       
REMARK 470     GLU D 281    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 282    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 283    CG   OD1  OD2                                       
REMARK 470     ASP E 522    CB   CG   OD1  OD2                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    ILE I   267     CB   THR I   272              2.06            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    PRO B  58       39.66    -91.60                                   
REMARK 500    ARG B 129       26.41   -141.09                                   
REMARK 500    ASN B 210       51.04     35.79                                   
REMARK 500    SER B 433       68.02     60.55                                   
REMARK 500    LEU J 104     -169.15   -125.72                                   
REMARK 500    SER J 223       75.40     61.43                                   
REMARK 500    LEU J 232       67.40     60.26                                   
REMARK 500    ASN J 274      -60.02   -147.39                                   
REMARK 500    ASP J 288       54.57    -92.59                                   
REMARK 500    GLN H 156       79.61   -108.44                                   
REMARK 500    ALA C 195       62.33   -113.82                                   
REMARK 500    ASP F 239       36.92    -98.76                                   
REMARK 500    ASN F 245       41.11     36.21                                   
REMARK 500    SER F 416     -159.86   -149.83                                   
REMARK 500    ASN F 475       65.99   -100.69                                   
REMARK 500    ASP F 498      -60.19    -92.29                                   
REMARK 500    PRO A  58       39.70    -91.69                                   
REMARK 500    ARG A 129       26.37   -141.05                                   
REMARK 500    ASN A 210       50.93     35.90                                   
REMARK 500    SER A 433       68.06     60.54                                   
REMARK 500    LEU I 104     -169.21   -125.70                                   
REMARK 500    SER I 223       75.48     61.37                                   
REMARK 500    LEU I 232       67.57     60.12                                   
REMARK 500    LEU I 273      -17.40   -158.47                                   
REMARK 500    ASP I 288       54.77    -92.74                                   
REMARK 500    GLN G 156       79.71   -108.52                                   
REMARK 500    ALA D 195       62.25   -113.87                                   
REMARK 500    ASP E 239       36.92    -98.80                                   
REMARK 500    ASN E 245       41.09     36.26                                   
REMARK 500    SER E 416     -159.84   -149.79                                   
REMARK 500    ASN E 475       66.07   -100.69                                   
REMARK 500    ASP E 498      -60.18    -92.32                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 GLN H  156     PRO H  157                  140.49                    
REMARK 500 ALA C  195     PRO C  196                  142.84                    
REMARK 500 GLN G  156     PRO G  157                  140.39                    
REMARK 500 ALA D  195     PRO D  196                  143.00                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue C7B C 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide PHE I 266 and THR I    
REMARK 800  272                                                                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide PHE I 266 and THR I    
REMARK 800  272                                                                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-7442   RELATED DB: EMDB                              
REMARK 900 ELECTRON CRYO-MICROSCOPY OF THE EUKARYOTIC TRANSLATION INITIATION    
REMARK 900 FACTOR 2B FROM HOMO SAPIENS                                          
REMARK 900 RELATED ID: EMD-7443   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-7444   RELATED DB: EMDB                              
REMARK 900 RELATED ID: 6CAJ   RELATED DB: PDB                                   
DBREF  6CAJ B    1   721  UNP    Q13144   EI2BE_HUMAN      1    721             
DBREF  6CAJ J    1   452  UNP    Q9NR50   EI2BG_HUMAN      1    452             
DBREF  6CAJ H    1   305  UNP    Q14232   EI2BA_HUMAN      1    305             
DBREF  6CAJ C    2   351  UNP    P49770   EI2BB_HUMAN      2    351             
DBREF  6CAJ F    1   523  UNP    Q9UI10   EI2BD_HUMAN      1    523             
DBREF  6CAJ A    1   721  UNP    Q13144   EI2BE_HUMAN      1    721             
DBREF  6CAJ I    1   452  UNP    Q9NR50   EI2BG_HUMAN      1    452             
DBREF  6CAJ G    1   305  UNP    Q14232   EI2BA_HUMAN      1    305             
DBREF  6CAJ D    2   351  UNP    P49770   EI2BB_HUMAN      2    351             
DBREF  6CAJ E    1   523  UNP    Q9UI10   EI2BD_HUMAN      1    523             
SEQADV 6CAJ VAL B  587  UNP  Q13144    ILE   587 VARIANT                        
SEQADV 6CAJ MET C  -16  UNP  P49770              INITIATING METHIONINE          
SEQADV 6CAJ HIS C  -15  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ HIS C  -14  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ HIS C  -13  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ HIS C  -12  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ HIS C  -11  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ HIS C  -10  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ GLY C   -9  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ GLY C   -8  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ GLY C   -7  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ SER C   -6  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ GLU C   -5  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ ASN C   -4  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ LEU C   -3  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ TYR C   -2  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ PHE C   -1  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ GLN C    0  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ SER C    1  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ VAL A  587  UNP  Q13144    ILE   587 VARIANT                        
SEQADV 6CAJ MET D  -16  UNP  P49770              INITIATING METHIONINE          
SEQADV 6CAJ HIS D  -15  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ HIS D  -14  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ HIS D  -13  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ HIS D  -12  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ HIS D  -11  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ HIS D  -10  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ GLY D   -9  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ GLY D   -8  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ GLY D   -7  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ SER D   -6  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ GLU D   -5  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ ASN D   -4  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ LEU D   -3  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ TYR D   -2  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ PHE D   -1  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ GLN D    0  UNP  P49770              EXPRESSION TAG                 
SEQADV 6CAJ SER D    1  UNP  P49770              EXPRESSION TAG                 
SEQRES   1 B  721  MET ALA ALA PRO VAL VAL ALA PRO PRO GLY VAL VAL VAL          
SEQRES   2 B  721  SER ARG ALA ASN LYS ARG SER GLY ALA GLY PRO GLY GLY          
SEQRES   3 B  721  SER GLY GLY GLY GLY ALA ARG GLY ALA GLU GLU GLU PRO          
SEQRES   4 B  721  PRO PRO PRO LEU GLN ALA VAL LEU VAL ALA ASP SER PHE          
SEQRES   5 B  721  ASP ARG ARG PHE PHE PRO ILE SER LYS ASP GLN PRO ARG          
SEQRES   6 B  721  VAL LEU LEU PRO LEU ALA ASN VAL ALA LEU ILE ASP TYR          
SEQRES   7 B  721  THR LEU GLU PHE LEU THR ALA THR GLY VAL GLN GLU THR          
SEQRES   8 B  721  PHE VAL PHE CYS CYS TRP LYS ALA ALA GLN ILE LYS GLU          
SEQRES   9 B  721  HIS LEU LEU LYS SER LYS TRP CYS ARG PRO THR SER LEU          
SEQRES  10 B  721  ASN VAL VAL ARG ILE ILE THR SER GLU LEU TYR ARG SER          
SEQRES  11 B  721  LEU GLY ASP VAL LEU ARG ASP VAL ASP ALA LYS ALA LEU          
SEQRES  12 B  721  VAL ARG SER ASP PHE LEU LEU VAL TYR GLY ASP VAL ILE          
SEQRES  13 B  721  SER ASN ILE ASN ILE THR ARG ALA LEU GLU GLU HIS ARG          
SEQRES  14 B  721  LEU ARG ARG LYS LEU GLU LYS ASN VAL SER VAL MET THR          
SEQRES  15 B  721  MET ILE PHE LYS GLU SER SER PRO SER HIS PRO THR ARG          
SEQRES  16 B  721  CYS HIS GLU ASP ASN VAL VAL VAL ALA VAL ASP SER THR          
SEQRES  17 B  721  THR ASN ARG VAL LEU HIS PHE GLN LYS THR GLN GLY LEU          
SEQRES  18 B  721  ARG ARG PHE ALA PHE PRO LEU SER LEU PHE GLN GLY SER          
SEQRES  19 B  721  SER ASP GLY VAL GLU VAL ARG TYR ASP LEU LEU ASP CYS          
SEQRES  20 B  721  HIS ILE SER ILE CYS SER PRO GLN VAL ALA GLN LEU PHE          
SEQRES  21 B  721  THR ASP ASN PHE ASP TYR GLN THR ARG ASP ASP PHE VAL          
SEQRES  22 B  721  ARG GLY LEU LEU VAL ASN GLU GLU ILE LEU GLY ASN GLN          
SEQRES  23 B  721  ILE HIS MET HIS VAL THR ALA LYS GLU TYR GLY ALA ARG          
SEQRES  24 B  721  VAL SER ASN LEU HIS MET TYR SER ALA VAL CYS ALA ASP          
SEQRES  25 B  721  VAL ILE ARG ARG TRP VAL TYR PRO LEU THR PRO GLU ALA          
SEQRES  26 B  721  ASN PHE THR ASP SER THR THR GLN SER CYS THR HIS SER          
SEQRES  27 B  721  ARG HIS ASN ILE TYR ARG GLY PRO GLU VAL SER LEU GLY          
SEQRES  28 B  721  HIS GLY SER ILE LEU GLU GLU ASN VAL LEU LEU GLY SER          
SEQRES  29 B  721  GLY THR VAL ILE GLY SER ASN CYS PHE ILE THR ASN SER          
SEQRES  30 B  721  VAL ILE GLY PRO GLY CYS HIS ILE GLY ASP ASN VAL VAL          
SEQRES  31 B  721  LEU ASP GLN THR TYR LEU TRP GLN GLY VAL ARG VAL ALA          
SEQRES  32 B  721  ALA GLY ALA GLN ILE HIS GLN SER LEU LEU CYS ASP ASN          
SEQRES  33 B  721  ALA GLU VAL LYS GLU ARG VAL THR LEU LYS PRO ARG SER          
SEQRES  34 B  721  VAL LEU THR SER GLN VAL VAL VAL GLY PRO ASN ILE THR          
SEQRES  35 B  721  LEU PRO GLU GLY SER VAL ILE SER LEU HIS PRO PRO ASP          
SEQRES  36 B  721  ALA GLU GLU ASP GLU ASP ASP GLY GLU PHE SER ASP ASP          
SEQRES  37 B  721  SER GLY ALA ASP GLN GLU LYS ASP LYS VAL LYS MET LYS          
SEQRES  38 B  721  GLY TYR ASN PRO ALA GLU VAL GLY ALA ALA GLY LYS GLY          
SEQRES  39 B  721  TYR LEU TRP LYS ALA ALA GLY MET ASN MET GLU GLU GLU          
SEQRES  40 B  721  GLU GLU LEU GLN GLN ASN LEU TRP GLY LEU LYS ILE ASN          
SEQRES  41 B  721  MET GLU GLU GLU SER GLU SER GLU SER GLU GLN SER MET          
SEQRES  42 B  721  ASP SER GLU GLU PRO ASP SER ARG GLY GLY SER PRO GLN          
SEQRES  43 B  721  MET ASP ASP ILE LYS VAL PHE GLN ASN GLU VAL LEU GLY          
SEQRES  44 B  721  THR LEU GLN ARG GLY LYS GLU GLU ASN ILE SER CYS ASP          
SEQRES  45 B  721  ASN LEU VAL LEU GLU ILE ASN SER LEU LYS TYR ALA TYR          
SEQRES  46 B  721  ASN VAL SER LEU LYS GLU VAL MET GLN VAL LEU SER HIS          
SEQRES  47 B  721  VAL VAL LEU GLU PHE PRO LEU GLN GLN MET ASP SER PRO          
SEQRES  48 B  721  LEU ASP SER SER ARG TYR CYS ALA LEU LEU LEU PRO LEU          
SEQRES  49 B  721  LEU LYS ALA TRP SER PRO VAL PHE ARG ASN TYR ILE LYS          
SEQRES  50 B  721  ARG ALA ALA ASP HIS LEU GLU ALA LEU ALA ALA ILE GLU          
SEQRES  51 B  721  ASP PHE PHE LEU GLU HIS GLU ALA LEU GLY ILE SER MET          
SEQRES  52 B  721  ALA LYS VAL LEU MET ALA PHE TYR GLN LEU GLU ILE LEU          
SEQRES  53 B  721  ALA GLU GLU THR ILE LEU SER TRP PHE SER GLN ARG ASP          
SEQRES  54 B  721  THR THR ASP LYS GLY GLN GLN LEU ARG LYS ASN GLN GLN          
SEQRES  55 B  721  LEU GLN ARG PHE ILE GLN TRP LEU LYS GLU ALA GLU GLU          
SEQRES  56 B  721  GLU SER SER GLU ASP ASP                                      
SEQRES   1 J  452  MET GLU PHE GLN ALA VAL VAL MET ALA VAL GLY GLY GLY          
SEQRES   2 J  452  SER ARG MET THR ASP LEU THR SER SER ILE PRO LYS PRO          
SEQRES   3 J  452  LEU LEU PRO VAL GLY ASN LYS PRO LEU ILE TRP TYR PRO          
SEQRES   4 J  452  LEU ASN LEU LEU GLU ARG VAL GLY PHE GLU GLU VAL ILE          
SEQRES   5 J  452  VAL VAL THR THR ARG ASP VAL GLN LYS ALA LEU CYS ALA          
SEQRES   6 J  452  GLU PHE LYS MET LYS MET LYS PRO ASP ILE VAL CYS ILE          
SEQRES   7 J  452  PRO ASP ASP ALA ASP MET GLY THR ALA ASP SER LEU ARG          
SEQRES   8 J  452  TYR ILE TYR PRO LYS LEU LYS THR ASP VAL LEU VAL LEU          
SEQRES   9 J  452  SER CYS ASP LEU ILE THR ASP VAL ALA LEU HIS GLU VAL          
SEQRES  10 J  452  VAL ASP LEU PHE ARG ALA TYR ASP ALA SER LEU ALA MET          
SEQRES  11 J  452  LEU MET ARG LYS GLY GLN ASP SER ILE GLU PRO VAL PRO          
SEQRES  12 J  452  GLY GLN LYS GLY LYS LYS LYS ALA VAL GLU GLN ARG ASP          
SEQRES  13 J  452  PHE ILE GLY VAL ASP SER THR GLY LYS ARG LEU LEU PHE          
SEQRES  14 J  452  MET ALA ASN GLU ALA ASP LEU ASP GLU GLU LEU VAL ILE          
SEQRES  15 J  452  LYS GLY SER ILE LEU GLN LYS HIS PRO ARG ILE ARG PHE          
SEQRES  16 J  452  HIS THR GLY LEU VAL ASP ALA HIS LEU TYR CYS LEU LYS          
SEQRES  17 J  452  LYS TYR ILE VAL ASP PHE LEU MET GLU ASN GLY SER ILE          
SEQRES  18 J  452  THR SER ILE ARG SER GLU LEU ILE PRO TYR LEU VAL ARG          
SEQRES  19 J  452  LYS GLN PHE SER SER ALA SER SER GLN GLN GLY GLN GLU          
SEQRES  20 J  452  GLU LYS GLU GLU ASP LEU LYS LYS LYS GLU LEU LYS SER          
SEQRES  21 J  452  LEU ASP ILE TYR SER PHE ILE LYS GLU ALA ASN THR LEU          
SEQRES  22 J  452  ASN LEU ALA PRO TYR ASP ALA CYS TRP ASN ALA CYS ARG          
SEQRES  23 J  452  GLY ASP ARG TRP GLU ASP LEU SER ARG SER GLN VAL ARG          
SEQRES  24 J  452  CYS TYR VAL HIS ILE MET LYS GLU GLY LEU CYS SER ARG          
SEQRES  25 J  452  VAL SER THR LEU GLY LEU TYR MET GLU ALA ASN ARG GLN          
SEQRES  26 J  452  VAL PRO LYS LEU LEU SER ALA LEU CYS PRO GLU GLU PRO          
SEQRES  27 J  452  PRO VAL HIS SER SER ALA GLN ILE VAL SER LYS HIS LEU          
SEQRES  28 J  452  VAL GLY VAL ASP SER LEU ILE GLY PRO GLU THR GLN ILE          
SEQRES  29 J  452  GLY GLU LYS SER SER ILE LYS ARG SER VAL ILE GLY SER          
SEQRES  30 J  452  SER CYS LEU ILE LYS ASP ARG VAL THR ILE THR ASN CYS          
SEQRES  31 J  452  LEU LEU MET ASN SER VAL THR VAL GLU GLU GLY SER ASN          
SEQRES  32 J  452  ILE GLN GLY SER VAL ILE CYS ASN ASN ALA VAL ILE GLU          
SEQRES  33 J  452  LYS GLY ALA ASP ILE LYS ASP CYS LEU ILE GLY SER GLY          
SEQRES  34 J  452  GLN ARG ILE GLU ALA LYS ALA LYS ARG VAL ASN GLU VAL          
SEQRES  35 J  452  ILE VAL GLY ASN ASP GLN LEU MET GLU ILE                      
SEQRES   1 H  305  MET ASP ASP LYS GLU LEU ILE GLU TYR PHE LYS SER GLN          
SEQRES   2 H  305  MET LYS GLU ASP PRO ASP MET ALA SER ALA VAL ALA ALA          
SEQRES   3 H  305  ILE ARG THR LEU LEU GLU PHE LEU LYS ARG ASP LYS GLY          
SEQRES   4 H  305  GLU THR ILE GLN GLY LEU ARG ALA ASN LEU THR SER ALA          
SEQRES   5 H  305  ILE GLU THR LEU CYS GLY VAL ASP SER SER VAL ALA VAL          
SEQRES   6 H  305  SER SER GLY GLY GLU LEU PHE LEU ARG PHE ILE SER LEU          
SEQRES   7 H  305  ALA SER LEU GLU TYR SER ASP TYR SER LYS CYS LYS LYS          
SEQRES   8 H  305  ILE MET ILE GLU ARG GLY GLU LEU PHE LEU ARG ARG ILE          
SEQRES   9 H  305  SER LEU SER ARG ASN LYS ILE ALA ASP LEU CYS HIS THR          
SEQRES  10 H  305  PHE ILE LYS ASP GLY ALA THR ILE LEU THR HIS ALA TYR          
SEQRES  11 H  305  SER ARG VAL VAL LEU ARG VAL LEU GLU ALA ALA VAL ALA          
SEQRES  12 H  305  ALA LYS LYS ARG PHE SER VAL TYR VAL THR GLU SER GLN          
SEQRES  13 H  305  PRO ASP LEU SER GLY LYS LYS MET ALA LYS ALA LEU CYS          
SEQRES  14 H  305  HIS LEU ASN VAL PRO VAL THR VAL VAL LEU ASP ALA ALA          
SEQRES  15 H  305  VAL GLY TYR ILE MET GLU LYS ALA ASP LEU VAL ILE VAL          
SEQRES  16 H  305  GLY ALA GLU GLY VAL VAL GLU ASN GLY GLY ILE ILE ASN          
SEQRES  17 H  305  LYS ILE GLY THR ASN GLN MET ALA VAL CYS ALA LYS ALA          
SEQRES  18 H  305  GLN ASN LYS PRO PHE TYR VAL VAL ALA GLU SER PHE LYS          
SEQRES  19 H  305  PHE VAL ARG LEU PHE PRO LEU ASN GLN GLN ASP VAL PRO          
SEQRES  20 H  305  ASP LYS PHE LYS TYR LYS ALA ASP THR LEU LYS VAL ALA          
SEQRES  21 H  305  GLN THR GLY GLN ASP LEU LYS GLU GLU HIS PRO TRP VAL          
SEQRES  22 H  305  ASP TYR THR ALA PRO SER LEU ILE THR LEU LEU PHE THR          
SEQRES  23 H  305  ASP LEU GLY VAL LEU THR PRO SER ALA VAL SER ASP GLU          
SEQRES  24 H  305  LEU ILE LYS LEU TYR LEU                                      
SEQRES   1 C  368  MET HIS HIS HIS HIS HIS HIS GLY GLY GLY SER GLU ASN          
SEQRES   2 C  368  LEU TYR PHE GLN SER PRO GLY SER ALA ALA LYS GLY SER          
SEQRES   3 C  368  GLU LEU SER GLU ARG ILE GLU SER PHE VAL GLU THR LEU          
SEQRES   4 C  368  LYS ARG GLY GLY GLY PRO ARG SER SER GLU GLU MET ALA          
SEQRES   5 C  368  ARG GLU THR LEU GLY LEU LEU ARG GLN ILE ILE THR ASP          
SEQRES   6 C  368  HIS ARG TRP SER ASN ALA GLY GLU LEU MET GLU LEU ILE          
SEQRES   7 C  368  ARG ARG GLU GLY ARG ARG MET THR ALA ALA GLN PRO SER          
SEQRES   8 C  368  GLU THR THR VAL GLY ASN MET VAL ARG ARG VAL LEU LYS          
SEQRES   9 C  368  ILE ILE ARG GLU GLU TYR GLY ARG LEU HIS GLY ARG SER          
SEQRES  10 C  368  ASP GLU SER ASP GLN GLN GLU SER LEU HIS LYS LEU LEU          
SEQRES  11 C  368  THR SER GLY GLY LEU ASN GLU ASP PHE SER PHE HIS TYR          
SEQRES  12 C  368  ALA GLN LEU GLN SER ASN ILE ILE GLU ALA ILE ASN GLU          
SEQRES  13 C  368  LEU LEU VAL GLU LEU GLU GLY THR MET GLU ASN ILE ALA          
SEQRES  14 C  368  ALA GLN ALA LEU GLU HIS ILE HIS SER ASN GLU VAL ILE          
SEQRES  15 C  368  MET THR ILE GLY PHE SER ARG THR VAL GLU ALA PHE LEU          
SEQRES  16 C  368  LYS GLU ALA ALA ARG LYS ARG LYS PHE HIS VAL ILE VAL          
SEQRES  17 C  368  ALA GLU CYS ALA PRO PHE CYS GLN GLY HIS GLU MET ALA          
SEQRES  18 C  368  VAL ASN LEU SER LYS ALA GLY ILE GLU THR THR VAL MET          
SEQRES  19 C  368  THR ASP ALA ALA ILE PHE ALA VAL MET SER ARG VAL ASN          
SEQRES  20 C  368  LYS VAL ILE ILE GLY THR LYS THR ILE LEU ALA ASN GLY          
SEQRES  21 C  368  ALA LEU ARG ALA VAL THR GLY THR HIS THR LEU ALA LEU          
SEQRES  22 C  368  ALA ALA LYS HIS HIS SER THR PRO LEU ILE VAL CYS ALA          
SEQRES  23 C  368  PRO MET PHE LYS LEU SER PRO GLN PHE PRO ASN GLU GLU          
SEQRES  24 C  368  ASP SER PHE HIS LYS PHE VAL ALA PRO GLU GLU VAL LEU          
SEQRES  25 C  368  PRO PHE THR GLU GLY ASP ILE LEU GLU LYS VAL SER VAL          
SEQRES  26 C  368  HIS CYS PRO VAL PHE ASP TYR VAL PRO PRO GLU LEU ILE          
SEQRES  27 C  368  THR LEU PHE ILE SER ASN ILE GLY GLY ASN ALA PRO SER          
SEQRES  28 C  368  TYR ILE TYR ARG LEU MET SER GLU LEU TYR HIS PRO ASP          
SEQRES  29 C  368  ASP HIS VAL LEU                                              
SEQRES   1 F  523  MET ALA ALA VAL ALA VAL ALA VAL ARG GLU ASP SER GLY          
SEQRES   2 F  523  SER GLY MET LYS ALA GLU LEU PRO PRO GLY PRO GLY ALA          
SEQRES   3 F  523  VAL GLY ARG GLU MET THR LYS GLU GLU LYS LEU GLN LEU          
SEQRES   4 F  523  ARG LYS GLU LYS LYS GLN GLN LYS LYS LYS ARG LYS GLU          
SEQRES   5 F  523  GLU LYS GLY ALA GLU PRO GLU THR GLY SER ALA VAL SER          
SEQRES   6 F  523  ALA ALA GLN CYS GLN VAL GLY PRO THR ARG GLU LEU PRO          
SEQRES   7 F  523  GLU SER GLY ILE GLN LEU GLY THR PRO ARG GLU LYS VAL          
SEQRES   8 F  523  PRO ALA GLY ARG SER LYS ALA GLU LEU ARG ALA GLU ARG          
SEQRES   9 F  523  ARG ALA LYS GLN GLU ALA GLU ARG ALA LEU LYS GLN ALA          
SEQRES  10 F  523  ARG LYS GLY GLU GLN GLY GLY PRO PRO PRO LYS ALA SER          
SEQRES  11 F  523  PRO SER THR ALA GLY GLU THR PRO SER GLY VAL LYS ARG          
SEQRES  12 F  523  LEU PRO GLU TYR PRO GLN VAL ASP ASP LEU LEU LEU ARG          
SEQRES  13 F  523  ARG LEU VAL LYS LYS PRO GLU ARG GLN GLN VAL PRO THR          
SEQRES  14 F  523  ARG LYS ASP TYR GLY SER LYS VAL SER LEU PHE SER HIS          
SEQRES  15 F  523  LEU PRO GLN TYR SER ARG GLN ASN SER LEU THR GLN PHE          
SEQRES  16 F  523  MET SER ILE PRO SER SER VAL ILE HIS PRO ALA MET VAL          
SEQRES  17 F  523  ARG LEU GLY LEU GLN TYR SER GLN GLY LEU VAL SER GLY          
SEQRES  18 F  523  SER ASN ALA ARG CYS ILE ALA LEU LEU ARG ALA LEU GLN          
SEQRES  19 F  523  GLN VAL ILE GLN ASP TYR THR THR PRO PRO ASN GLU GLU          
SEQRES  20 F  523  LEU SER ARG ASP LEU VAL ASN LYS LEU LYS PRO TYR MET          
SEQRES  21 F  523  SER PHE LEU THR GLN CYS ARG PRO LEU SER ALA SER MET          
SEQRES  22 F  523  HIS ASN ALA ILE LYS PHE LEU ASN LYS GLU ILE THR SER          
SEQRES  23 F  523  VAL GLY SER SER LYS ARG GLU GLU GLU ALA LYS SER GLU          
SEQRES  24 F  523  LEU ARG ALA ALA ILE ASP ARG TYR VAL GLN GLU LYS ILE          
SEQRES  25 F  523  VAL LEU ALA ALA GLN ALA ILE SER ARG PHE ALA TYR GLN          
SEQRES  26 F  523  LYS ILE SER ASN GLY ASP VAL ILE LEU VAL TYR GLY CYS          
SEQRES  27 F  523  SER SER LEU VAL SER ARG ILE LEU GLN GLU ALA TRP THR          
SEQRES  28 F  523  GLU GLY ARG ARG PHE ARG VAL VAL VAL VAL ASP SER ARG          
SEQRES  29 F  523  PRO TRP LEU GLU GLY ARG HIS THR LEU ARG SER LEU VAL          
SEQRES  30 F  523  HIS ALA GLY VAL PRO ALA SER TYR LEU LEU ILE PRO ALA          
SEQRES  31 F  523  ALA SER TYR VAL LEU PRO GLU VAL SER LYS VAL LEU LEU          
SEQRES  32 F  523  GLY ALA HIS ALA LEU LEU ALA ASN GLY SER VAL MET SER          
SEQRES  33 F  523  ARG VAL GLY THR ALA GLN LEU ALA LEU VAL ALA ARG ALA          
SEQRES  34 F  523  HIS ASN VAL PRO VAL LEU VAL CYS CYS GLU THR TYR LYS          
SEQRES  35 F  523  PHE CYS GLU ARG VAL GLN THR ASP ALA PHE VAL SER ASN          
SEQRES  36 F  523  GLU LEU ASP ASP PRO ASP ASP LEU GLN CYS LYS ARG GLY          
SEQRES  37 F  523  GLU HIS VAL ALA LEU ALA ASN TRP GLN ASN HIS ALA SER          
SEQRES  38 F  523  LEU ARG LEU LEU ASN LEU VAL TYR ASP VAL THR PRO PRO          
SEQRES  39 F  523  GLU LEU VAL ASP LEU VAL ILE THR GLU LEU GLY MET ILE          
SEQRES  40 F  523  PRO CYS SER SER VAL PRO VAL VAL LEU ARG VAL LYS SER          
SEQRES  41 F  523  SER ASP GLN                                                  
SEQRES   1 A  721  MET ALA ALA PRO VAL VAL ALA PRO PRO GLY VAL VAL VAL          
SEQRES   2 A  721  SER ARG ALA ASN LYS ARG SER GLY ALA GLY PRO GLY GLY          
SEQRES   3 A  721  SER GLY GLY GLY GLY ALA ARG GLY ALA GLU GLU GLU PRO          
SEQRES   4 A  721  PRO PRO PRO LEU GLN ALA VAL LEU VAL ALA ASP SER PHE          
SEQRES   5 A  721  ASP ARG ARG PHE PHE PRO ILE SER LYS ASP GLN PRO ARG          
SEQRES   6 A  721  VAL LEU LEU PRO LEU ALA ASN VAL ALA LEU ILE ASP TYR          
SEQRES   7 A  721  THR LEU GLU PHE LEU THR ALA THR GLY VAL GLN GLU THR          
SEQRES   8 A  721  PHE VAL PHE CYS CYS TRP LYS ALA ALA GLN ILE LYS GLU          
SEQRES   9 A  721  HIS LEU LEU LYS SER LYS TRP CYS ARG PRO THR SER LEU          
SEQRES  10 A  721  ASN VAL VAL ARG ILE ILE THR SER GLU LEU TYR ARG SER          
SEQRES  11 A  721  LEU GLY ASP VAL LEU ARG ASP VAL ASP ALA LYS ALA LEU          
SEQRES  12 A  721  VAL ARG SER ASP PHE LEU LEU VAL TYR GLY ASP VAL ILE          
SEQRES  13 A  721  SER ASN ILE ASN ILE THR ARG ALA LEU GLU GLU HIS ARG          
SEQRES  14 A  721  LEU ARG ARG LYS LEU GLU LYS ASN VAL SER VAL MET THR          
SEQRES  15 A  721  MET ILE PHE LYS GLU SER SER PRO SER HIS PRO THR ARG          
SEQRES  16 A  721  CYS HIS GLU ASP ASN VAL VAL VAL ALA VAL ASP SER THR          
SEQRES  17 A  721  THR ASN ARG VAL LEU HIS PHE GLN LYS THR GLN GLY LEU          
SEQRES  18 A  721  ARG ARG PHE ALA PHE PRO LEU SER LEU PHE GLN GLY SER          
SEQRES  19 A  721  SER ASP GLY VAL GLU VAL ARG TYR ASP LEU LEU ASP CYS          
SEQRES  20 A  721  HIS ILE SER ILE CYS SER PRO GLN VAL ALA GLN LEU PHE          
SEQRES  21 A  721  THR ASP ASN PHE ASP TYR GLN THR ARG ASP ASP PHE VAL          
SEQRES  22 A  721  ARG GLY LEU LEU VAL ASN GLU GLU ILE LEU GLY ASN GLN          
SEQRES  23 A  721  ILE HIS MET HIS VAL THR ALA LYS GLU TYR GLY ALA ARG          
SEQRES  24 A  721  VAL SER ASN LEU HIS MET TYR SER ALA VAL CYS ALA ASP          
SEQRES  25 A  721  VAL ILE ARG ARG TRP VAL TYR PRO LEU THR PRO GLU ALA          
SEQRES  26 A  721  ASN PHE THR ASP SER THR THR GLN SER CYS THR HIS SER          
SEQRES  27 A  721  ARG HIS ASN ILE TYR ARG GLY PRO GLU VAL SER LEU GLY          
SEQRES  28 A  721  HIS GLY SER ILE LEU GLU GLU ASN VAL LEU LEU GLY SER          
SEQRES  29 A  721  GLY THR VAL ILE GLY SER ASN CYS PHE ILE THR ASN SER          
SEQRES  30 A  721  VAL ILE GLY PRO GLY CYS HIS ILE GLY ASP ASN VAL VAL          
SEQRES  31 A  721  LEU ASP GLN THR TYR LEU TRP GLN GLY VAL ARG VAL ALA          
SEQRES  32 A  721  ALA GLY ALA GLN ILE HIS GLN SER LEU LEU CYS ASP ASN          
SEQRES  33 A  721  ALA GLU VAL LYS GLU ARG VAL THR LEU LYS PRO ARG SER          
SEQRES  34 A  721  VAL LEU THR SER GLN VAL VAL VAL GLY PRO ASN ILE THR          
SEQRES  35 A  721  LEU PRO GLU GLY SER VAL ILE SER LEU HIS PRO PRO ASP          
SEQRES  36 A  721  ALA GLU GLU ASP GLU ASP ASP GLY GLU PHE SER ASP ASP          
SEQRES  37 A  721  SER GLY ALA ASP GLN GLU LYS ASP LYS VAL LYS MET LYS          
SEQRES  38 A  721  GLY TYR ASN PRO ALA GLU VAL GLY ALA ALA GLY LYS GLY          
SEQRES  39 A  721  TYR LEU TRP LYS ALA ALA GLY MET ASN MET GLU GLU GLU          
SEQRES  40 A  721  GLU GLU LEU GLN GLN ASN LEU TRP GLY LEU LYS ILE ASN          
SEQRES  41 A  721  MET GLU GLU GLU SER GLU SER GLU SER GLU GLN SER MET          
SEQRES  42 A  721  ASP SER GLU GLU PRO ASP SER ARG GLY GLY SER PRO GLN          
SEQRES  43 A  721  MET ASP ASP ILE LYS VAL PHE GLN ASN GLU VAL LEU GLY          
SEQRES  44 A  721  THR LEU GLN ARG GLY LYS GLU GLU ASN ILE SER CYS ASP          
SEQRES  45 A  721  ASN LEU VAL LEU GLU ILE ASN SER LEU LYS TYR ALA TYR          
SEQRES  46 A  721  ASN VAL SER LEU LYS GLU VAL MET GLN VAL LEU SER HIS          
SEQRES  47 A  721  VAL VAL LEU GLU PHE PRO LEU GLN GLN MET ASP SER PRO          
SEQRES  48 A  721  LEU ASP SER SER ARG TYR CYS ALA LEU LEU LEU PRO LEU          
SEQRES  49 A  721  LEU LYS ALA TRP SER PRO VAL PHE ARG ASN TYR ILE LYS          
SEQRES  50 A  721  ARG ALA ALA ASP HIS LEU GLU ALA LEU ALA ALA ILE GLU          
SEQRES  51 A  721  ASP PHE PHE LEU GLU HIS GLU ALA LEU GLY ILE SER MET          
SEQRES  52 A  721  ALA LYS VAL LEU MET ALA PHE TYR GLN LEU GLU ILE LEU          
SEQRES  53 A  721  ALA GLU GLU THR ILE LEU SER TRP PHE SER GLN ARG ASP          
SEQRES  54 A  721  THR THR ASP LYS GLY GLN GLN LEU ARG LYS ASN GLN GLN          
SEQRES  55 A  721  LEU GLN ARG PHE ILE GLN TRP LEU LYS GLU ALA GLU GLU          
SEQRES  56 A  721  GLU SER SER GLU ASP ASP                                      
SEQRES   1 I  452  MET GLU PHE GLN ALA VAL VAL MET ALA VAL GLY GLY GLY          
SEQRES   2 I  452  SER ARG MET THR ASP LEU THR SER SER ILE PRO LYS PRO          
SEQRES   3 I  452  LEU LEU PRO VAL GLY ASN LYS PRO LEU ILE TRP TYR PRO          
SEQRES   4 I  452  LEU ASN LEU LEU GLU ARG VAL GLY PHE GLU GLU VAL ILE          
SEQRES   5 I  452  VAL VAL THR THR ARG ASP VAL GLN LYS ALA LEU CYS ALA          
SEQRES   6 I  452  GLU PHE LYS MET LYS MET LYS PRO ASP ILE VAL CYS ILE          
SEQRES   7 I  452  PRO ASP ASP ALA ASP MET GLY THR ALA ASP SER LEU ARG          
SEQRES   8 I  452  TYR ILE TYR PRO LYS LEU LYS THR ASP VAL LEU VAL LEU          
SEQRES   9 I  452  SER CYS ASP LEU ILE THR ASP VAL ALA LEU HIS GLU VAL          
SEQRES  10 I  452  VAL ASP LEU PHE ARG ALA TYR ASP ALA SER LEU ALA MET          
SEQRES  11 I  452  LEU MET ARG LYS GLY GLN ASP SER ILE GLU PRO VAL PRO          
SEQRES  12 I  452  GLY GLN LYS GLY LYS LYS LYS ALA VAL GLU GLN ARG ASP          
SEQRES  13 I  452  PHE ILE GLY VAL ASP SER THR GLY LYS ARG LEU LEU PHE          
SEQRES  14 I  452  MET ALA ASN GLU ALA ASP LEU ASP GLU GLU LEU VAL ILE          
SEQRES  15 I  452  LYS GLY SER ILE LEU GLN LYS HIS PRO ARG ILE ARG PHE          
SEQRES  16 I  452  HIS THR GLY LEU VAL ASP ALA HIS LEU TYR CYS LEU LYS          
SEQRES  17 I  452  LYS TYR ILE VAL ASP PHE LEU MET GLU ASN GLY SER ILE          
SEQRES  18 I  452  THR SER ILE ARG SER GLU LEU ILE PRO TYR LEU VAL ARG          
SEQRES  19 I  452  LYS GLN PHE SER SER ALA SER SER GLN GLN GLY GLN GLU          
SEQRES  20 I  452  GLU LYS GLU GLU ASP LEU LYS LYS LYS GLU LEU LYS SER          
SEQRES  21 I  452  LEU ASP ILE TYR SER PHE ILE LYS GLU ALA ASN THR LEU          
SEQRES  22 I  452  ASN LEU ALA PRO TYR ASP ALA CYS TRP ASN ALA CYS ARG          
SEQRES  23 I  452  GLY ASP ARG TRP GLU ASP LEU SER ARG SER GLN VAL ARG          
SEQRES  24 I  452  CYS TYR VAL HIS ILE MET LYS GLU GLY LEU CYS SER ARG          
SEQRES  25 I  452  VAL SER THR LEU GLY LEU TYR MET GLU ALA ASN ARG GLN          
SEQRES  26 I  452  VAL PRO LYS LEU LEU SER ALA LEU CYS PRO GLU GLU PRO          
SEQRES  27 I  452  PRO VAL HIS SER SER ALA GLN ILE VAL SER LYS HIS LEU          
SEQRES  28 I  452  VAL GLY VAL ASP SER LEU ILE GLY PRO GLU THR GLN ILE          
SEQRES  29 I  452  GLY GLU LYS SER SER ILE LYS ARG SER VAL ILE GLY SER          
SEQRES  30 I  452  SER CYS LEU ILE LYS ASP ARG VAL THR ILE THR ASN CYS          
SEQRES  31 I  452  LEU LEU MET ASN SER VAL THR VAL GLU GLU GLY SER ASN          
SEQRES  32 I  452  ILE GLN GLY SER VAL ILE CYS ASN ASN ALA VAL ILE GLU          
SEQRES  33 I  452  LYS GLY ALA ASP ILE LYS ASP CYS LEU ILE GLY SER GLY          
SEQRES  34 I  452  GLN ARG ILE GLU ALA LYS ALA LYS ARG VAL ASN GLU VAL          
SEQRES  35 I  452  ILE VAL GLY ASN ASP GLN LEU MET GLU ILE                      
SEQRES   1 G  305  MET ASP ASP LYS GLU LEU ILE GLU TYR PHE LYS SER GLN          
SEQRES   2 G  305  MET LYS GLU ASP PRO ASP MET ALA SER ALA VAL ALA ALA          
SEQRES   3 G  305  ILE ARG THR LEU LEU GLU PHE LEU LYS ARG ASP LYS GLY          
SEQRES   4 G  305  GLU THR ILE GLN GLY LEU ARG ALA ASN LEU THR SER ALA          
SEQRES   5 G  305  ILE GLU THR LEU CYS GLY VAL ASP SER SER VAL ALA VAL          
SEQRES   6 G  305  SER SER GLY GLY GLU LEU PHE LEU ARG PHE ILE SER LEU          
SEQRES   7 G  305  ALA SER LEU GLU TYR SER ASP TYR SER LYS CYS LYS LYS          
SEQRES   8 G  305  ILE MET ILE GLU ARG GLY GLU LEU PHE LEU ARG ARG ILE          
SEQRES   9 G  305  SER LEU SER ARG ASN LYS ILE ALA ASP LEU CYS HIS THR          
SEQRES  10 G  305  PHE ILE LYS ASP GLY ALA THR ILE LEU THR HIS ALA TYR          
SEQRES  11 G  305  SER ARG VAL VAL LEU ARG VAL LEU GLU ALA ALA VAL ALA          
SEQRES  12 G  305  ALA LYS LYS ARG PHE SER VAL TYR VAL THR GLU SER GLN          
SEQRES  13 G  305  PRO ASP LEU SER GLY LYS LYS MET ALA LYS ALA LEU CYS          
SEQRES  14 G  305  HIS LEU ASN VAL PRO VAL THR VAL VAL LEU ASP ALA ALA          
SEQRES  15 G  305  VAL GLY TYR ILE MET GLU LYS ALA ASP LEU VAL ILE VAL          
SEQRES  16 G  305  GLY ALA GLU GLY VAL VAL GLU ASN GLY GLY ILE ILE ASN          
SEQRES  17 G  305  LYS ILE GLY THR ASN GLN MET ALA VAL CYS ALA LYS ALA          
SEQRES  18 G  305  GLN ASN LYS PRO PHE TYR VAL VAL ALA GLU SER PHE LYS          
SEQRES  19 G  305  PHE VAL ARG LEU PHE PRO LEU ASN GLN GLN ASP VAL PRO          
SEQRES  20 G  305  ASP LYS PHE LYS TYR LYS ALA ASP THR LEU LYS VAL ALA          
SEQRES  21 G  305  GLN THR GLY GLN ASP LEU LYS GLU GLU HIS PRO TRP VAL          
SEQRES  22 G  305  ASP TYR THR ALA PRO SER LEU ILE THR LEU LEU PHE THR          
SEQRES  23 G  305  ASP LEU GLY VAL LEU THR PRO SER ALA VAL SER ASP GLU          
SEQRES  24 G  305  LEU ILE LYS LEU TYR LEU                                      
SEQRES   1 D  368  MET HIS HIS HIS HIS HIS HIS GLY GLY GLY SER GLU ASN          
SEQRES   2 D  368  LEU TYR PHE GLN SER PRO GLY SER ALA ALA LYS GLY SER          
SEQRES   3 D  368  GLU LEU SER GLU ARG ILE GLU SER PHE VAL GLU THR LEU          
SEQRES   4 D  368  LYS ARG GLY GLY GLY PRO ARG SER SER GLU GLU MET ALA          
SEQRES   5 D  368  ARG GLU THR LEU GLY LEU LEU ARG GLN ILE ILE THR ASP          
SEQRES   6 D  368  HIS ARG TRP SER ASN ALA GLY GLU LEU MET GLU LEU ILE          
SEQRES   7 D  368  ARG ARG GLU GLY ARG ARG MET THR ALA ALA GLN PRO SER          
SEQRES   8 D  368  GLU THR THR VAL GLY ASN MET VAL ARG ARG VAL LEU LYS          
SEQRES   9 D  368  ILE ILE ARG GLU GLU TYR GLY ARG LEU HIS GLY ARG SER          
SEQRES  10 D  368  ASP GLU SER ASP GLN GLN GLU SER LEU HIS LYS LEU LEU          
SEQRES  11 D  368  THR SER GLY GLY LEU ASN GLU ASP PHE SER PHE HIS TYR          
SEQRES  12 D  368  ALA GLN LEU GLN SER ASN ILE ILE GLU ALA ILE ASN GLU          
SEQRES  13 D  368  LEU LEU VAL GLU LEU GLU GLY THR MET GLU ASN ILE ALA          
SEQRES  14 D  368  ALA GLN ALA LEU GLU HIS ILE HIS SER ASN GLU VAL ILE          
SEQRES  15 D  368  MET THR ILE GLY PHE SER ARG THR VAL GLU ALA PHE LEU          
SEQRES  16 D  368  LYS GLU ALA ALA ARG LYS ARG LYS PHE HIS VAL ILE VAL          
SEQRES  17 D  368  ALA GLU CYS ALA PRO PHE CYS GLN GLY HIS GLU MET ALA          
SEQRES  18 D  368  VAL ASN LEU SER LYS ALA GLY ILE GLU THR THR VAL MET          
SEQRES  19 D  368  THR ASP ALA ALA ILE PHE ALA VAL MET SER ARG VAL ASN          
SEQRES  20 D  368  LYS VAL ILE ILE GLY THR LYS THR ILE LEU ALA ASN GLY          
SEQRES  21 D  368  ALA LEU ARG ALA VAL THR GLY THR HIS THR LEU ALA LEU          
SEQRES  22 D  368  ALA ALA LYS HIS HIS SER THR PRO LEU ILE VAL CYS ALA          
SEQRES  23 D  368  PRO MET PHE LYS LEU SER PRO GLN PHE PRO ASN GLU GLU          
SEQRES  24 D  368  ASP SER PHE HIS LYS PHE VAL ALA PRO GLU GLU VAL LEU          
SEQRES  25 D  368  PRO PHE THR GLU GLY ASP ILE LEU GLU LYS VAL SER VAL          
SEQRES  26 D  368  HIS CYS PRO VAL PHE ASP TYR VAL PRO PRO GLU LEU ILE          
SEQRES  27 D  368  THR LEU PHE ILE SER ASN ILE GLY GLY ASN ALA PRO SER          
SEQRES  28 D  368  TYR ILE TYR ARG LEU MET SER GLU LEU TYR HIS PRO ASP          
SEQRES  29 D  368  ASP HIS VAL LEU                                              
SEQRES   1 E  523  MET ALA ALA VAL ALA VAL ALA VAL ARG GLU ASP SER GLY          
SEQRES   2 E  523  SER GLY MET LYS ALA GLU LEU PRO PRO GLY PRO GLY ALA          
SEQRES   3 E  523  VAL GLY ARG GLU MET THR LYS GLU GLU LYS LEU GLN LEU          
SEQRES   4 E  523  ARG LYS GLU LYS LYS GLN GLN LYS LYS LYS ARG LYS GLU          
SEQRES   5 E  523  GLU LYS GLY ALA GLU PRO GLU THR GLY SER ALA VAL SER          
SEQRES   6 E  523  ALA ALA GLN CYS GLN VAL GLY PRO THR ARG GLU LEU PRO          
SEQRES   7 E  523  GLU SER GLY ILE GLN LEU GLY THR PRO ARG GLU LYS VAL          
SEQRES   8 E  523  PRO ALA GLY ARG SER LYS ALA GLU LEU ARG ALA GLU ARG          
SEQRES   9 E  523  ARG ALA LYS GLN GLU ALA GLU ARG ALA LEU LYS GLN ALA          
SEQRES  10 E  523  ARG LYS GLY GLU GLN GLY GLY PRO PRO PRO LYS ALA SER          
SEQRES  11 E  523  PRO SER THR ALA GLY GLU THR PRO SER GLY VAL LYS ARG          
SEQRES  12 E  523  LEU PRO GLU TYR PRO GLN VAL ASP ASP LEU LEU LEU ARG          
SEQRES  13 E  523  ARG LEU VAL LYS LYS PRO GLU ARG GLN GLN VAL PRO THR          
SEQRES  14 E  523  ARG LYS ASP TYR GLY SER LYS VAL SER LEU PHE SER HIS          
SEQRES  15 E  523  LEU PRO GLN TYR SER ARG GLN ASN SER LEU THR GLN PHE          
SEQRES  16 E  523  MET SER ILE PRO SER SER VAL ILE HIS PRO ALA MET VAL          
SEQRES  17 E  523  ARG LEU GLY LEU GLN TYR SER GLN GLY LEU VAL SER GLY          
SEQRES  18 E  523  SER ASN ALA ARG CYS ILE ALA LEU LEU ARG ALA LEU GLN          
SEQRES  19 E  523  GLN VAL ILE GLN ASP TYR THR THR PRO PRO ASN GLU GLU          
SEQRES  20 E  523  LEU SER ARG ASP LEU VAL ASN LYS LEU LYS PRO TYR MET          
SEQRES  21 E  523  SER PHE LEU THR GLN CYS ARG PRO LEU SER ALA SER MET          
SEQRES  22 E  523  HIS ASN ALA ILE LYS PHE LEU ASN LYS GLU ILE THR SER          
SEQRES  23 E  523  VAL GLY SER SER LYS ARG GLU GLU GLU ALA LYS SER GLU          
SEQRES  24 E  523  LEU ARG ALA ALA ILE ASP ARG TYR VAL GLN GLU LYS ILE          
SEQRES  25 E  523  VAL LEU ALA ALA GLN ALA ILE SER ARG PHE ALA TYR GLN          
SEQRES  26 E  523  LYS ILE SER ASN GLY ASP VAL ILE LEU VAL TYR GLY CYS          
SEQRES  27 E  523  SER SER LEU VAL SER ARG ILE LEU GLN GLU ALA TRP THR          
SEQRES  28 E  523  GLU GLY ARG ARG PHE ARG VAL VAL VAL VAL ASP SER ARG          
SEQRES  29 E  523  PRO TRP LEU GLU GLY ARG HIS THR LEU ARG SER LEU VAL          
SEQRES  30 E  523  HIS ALA GLY VAL PRO ALA SER TYR LEU LEU ILE PRO ALA          
SEQRES  31 E  523  ALA SER TYR VAL LEU PRO GLU VAL SER LYS VAL LEU LEU          
SEQRES  32 E  523  GLY ALA HIS ALA LEU LEU ALA ASN GLY SER VAL MET SER          
SEQRES  33 E  523  ARG VAL GLY THR ALA GLN LEU ALA LEU VAL ALA ARG ALA          
SEQRES  34 E  523  HIS ASN VAL PRO VAL LEU VAL CYS CYS GLU THR TYR LYS          
SEQRES  35 E  523  PHE CYS GLU ARG VAL GLN THR ASP ALA PHE VAL SER ASN          
SEQRES  36 E  523  GLU LEU ASP ASP PRO ASP ASP LEU GLN CYS LYS ARG GLY          
SEQRES  37 E  523  GLU HIS VAL ALA LEU ALA ASN TRP GLN ASN HIS ALA SER          
SEQRES  38 E  523  LEU ARG LEU LEU ASN LEU VAL TYR ASP VAL THR PRO PRO          
SEQRES  39 E  523  GLU LEU VAL ASP LEU VAL ILE THR GLU LEU GLY MET ILE          
SEQRES  40 E  523  PRO CYS SER SER VAL PRO VAL VAL LEU ARG VAL LYS SER          
SEQRES  41 E  523  SER ASP GLN                                                  
HET    C7B  C 401      60                                                       
HETNAM     C7B 2-(4-CHLORANYLPHENOXY)-~{N}-[4-[2-(4-CHLORANYLPHENOXY)           
HETNAM   2 C7B  ETHANOYLAMINO]CYCLOHEXYL]ETHANAMIDE                             
HETSYN     C7B ISRIB                                                            
FORMUL  11  C7B    C22 H24 CL2 N2 O4                                            
HELIX    1 AA1 PRO B   64  LEU B   68  5                                   5    
HELIX    2 AA2 ALA B   74  GLY B   87  1                                  14    
HELIX    3 AA3 LYS B   98  LYS B  108  1                                  11    
HELIX    4 AA4 SER B  109  ARG B  113  5                                   5    
HELIX    5 AA5 SER B  130  ALA B  142  1                                  13    
HELIX    6 AA6 ILE B  161  LYS B  176  1                                  16    
HELIX    7 AA7 LEU B  228  SER B  234  1                                   7    
HELIX    8 AA8 SER B  253  ASN B  263  1                                  11    
HELIX    9 AA9 THR B  268  VAL B  278  1                                  11    
HELIX   10 AB1 ASN B  302  ARG B  315  1                                  14    
HELIX   11 AB2 ARG B  339  ASN B  341  5                                   3    
HELIX   12 AB3 ILE J   36  VAL J   46  1                                  11    
HELIX   13 AB4 LEU J   63  LYS J   68  1                                   6    
HELIX   14 AB5 GLY J   85  ILE J   93  1                                   9    
HELIX   15 AB6 TYR J   94  LEU J   97  5                                   4    
HELIX   16 AB7 LEU J  114  TYR J  124  1                                  11    
HELIX   17 AB8 GLY J  184  HIS J  190  1                                   7    
HELIX   18 AB9 LYS J  208  ASN J  218  1                                  11    
HELIX   19 AC1 SER J  223  GLU J  227  5                                   5    
HELIX   20 AC2 ASN J  283  ASP J  288  1                                   6    
HELIX   21 AC3 GLU H    5  GLU H   16  1                                  12    
HELIX   22 AC4 ALA H   21  ARG H   36  1                                  16    
HELIX   23 AC5 LEU H   45  LEU H   56  1                                  12    
HELIX   24 AC6 SER H   62  SER H   77  1                                  16    
HELIX   25 AC7 ILE H   92  LEU H  106  1                                  15    
HELIX   26 AC8 LEU H  106  HIS H  116  1                                  11    
HELIX   27 AC9 SER H  131  ALA H  144  1                                  14    
HELIX   28 AD1 SER H  160  HIS H  170  1                                  11    
HELIX   29 AD2 LEU H  179  VAL H  183  5                                   5    
HELIX   30 AD3 GLY H  211  GLN H  222  1                                  12    
HELIX   31 AD4 PRO H  247  TYR H  252  1                                   6    
HELIX   32 AD5 ALA H  277  ILE H  281  5                                   5    
HELIX   33 AD6 PRO H  293  TYR H  304  1                                  12    
HELIX   34 AD7 SER C    9  GLY C   25  1                                  17    
HELIX   35 AD8 SER C   30  ASP C   48  1                                  19    
HELIX   36 AD9 ASN C   53  GLN C   72  1                                  20    
HELIX   37 AE1 GLU C   75  LEU C   96  1                                  22    
HELIX   38 AE2 TYR C  126  GLY C  146  1                                  21    
HELIX   39 AE3 GLY C  146  GLN C  154  1                                   9    
HELIX   40 AE4 ALA C  155  ILE C  159  5                                   5    
HELIX   41 AE5 SER C  171  ALA C  182  1                                  12    
HELIX   42 AE6 GLN C  199  LYS C  209  1                                  11    
HELIX   43 AE7 THR C  218  ALA C  220  5                                   3    
HELIX   44 AE8 ALA C  221  MET C  226  1                                   6    
HELIX   45 AE9 SER C  227  VAL C  229  5                                   3    
HELIX   46 AF1 GLY C  250  HIS C  261  1                                  12    
HELIX   47 AF2 PRO C  296  GLU C  304  5                                   9    
HELIX   48 AF3 PRO C  317  ILE C  321  5                                   5    
HELIX   49 AF4 ALA C  332  SER C  334  5                                   3    
HELIX   50 AF5 TYR C  335  TYR C  344  1                                  10    
HELIX   51 AF6 HIS C  345  HIS C  349  5                                   5    
HELIX   52 AF7 SER F  191  MET F  196  5                                   6    
HELIX   53 AF8 HIS F  204  GLN F  216  1                                  13    
HELIX   54 AF9 GLY F  221  ASP F  239  1                                  19    
HELIX   55 AG1 GLU F  247  ARG F  267  1                                  21    
HELIX   56 AG2 SER F  270  SER F  286  1                                  17    
HELIX   57 AG3 ARG F  292  GLN F  325  1                                  34    
HELIX   58 AG4 SER F  339  GLU F  352  1                                  14    
HELIX   59 AG5 GLU F  368  ALA F  379  1                                  12    
HELIX   60 AG6 ILE F  388  LEU F  395  1                                   8    
HELIX   61 AG7 THR F  420  HIS F  430  1                                  11    
HELIX   62 AG8 GLU F  439  PHE F  443  5                                   5    
HELIX   63 AG9 ASP F  459  LEU F  463  5                                   5    
HELIX   64 AH1 PRO F  508  SER F  510  5                                   3    
HELIX   65 AH2 SER F  511  SER F  520  1                                  10    
HELIX   66 AH3 PRO A   64  LEU A   68  5                                   5    
HELIX   67 AH4 ALA A   74  GLY A   87  1                                  14    
HELIX   68 AH5 LYS A   98  LYS A  108  1                                  11    
HELIX   69 AH6 SER A  109  ARG A  113  5                                   5    
HELIX   70 AH7 SER A  130  ALA A  142  1                                  13    
HELIX   71 AH8 ILE A  161  LYS A  176  1                                  16    
HELIX   72 AH9 LEU A  228  SER A  234  1                                   7    
HELIX   73 AI1 SER A  253  ASN A  263  1                                  11    
HELIX   74 AI2 THR A  268  VAL A  278  1                                  11    
HELIX   75 AI3 ASN A  302  ARG A  315  1                                  14    
HELIX   76 AI4 ARG A  339  ASN A  341  5                                   3    
HELIX   77 AI5 ILE I   36  VAL I   46  1                                  11    
HELIX   78 AI6 LEU I   63  LYS I   68  1                                   6    
HELIX   79 AI7 GLY I   85  ILE I   93  1                                   9    
HELIX   80 AI8 TYR I   94  LEU I   97  5                                   4    
HELIX   81 AI9 LEU I  114  TYR I  124  1                                  11    
HELIX   82 AJ1 GLY I  184  HIS I  190  1                                   7    
HELIX   83 AJ2 LYS I  208  ASN I  218  1                                  11    
HELIX   84 AJ3 SER I  223  GLU I  227  5                                   5    
HELIX   85 AJ4 ASN I  283  ASP I  288  1                                   6    
HELIX   86 AJ5 GLU G    5  GLU G   16  1                                  12    
HELIX   87 AJ6 ALA G   21  ARG G   36  1                                  16    
HELIX   88 AJ7 LEU G   45  LEU G   56  1                                  12    
HELIX   89 AJ8 SER G   62  SER G   77  1                                  16    
HELIX   90 AJ9 ILE G   92  LEU G  106  1                                  15    
HELIX   91 AK1 LEU G  106  HIS G  116  1                                  11    
HELIX   92 AK2 SER G  131  ALA G  144  1                                  14    
HELIX   93 AK3 SER G  160  HIS G  170  1                                  11    
HELIX   94 AK4 LEU G  179  VAL G  183  5                                   5    
HELIX   95 AK5 GLY G  211  GLN G  222  1                                  12    
HELIX   96 AK6 PRO G  247  TYR G  252  1                                   6    
HELIX   97 AK7 ALA G  277  ILE G  281  5                                   5    
HELIX   98 AK8 PRO G  293  TYR G  304  1                                  12    
HELIX   99 AK9 SER D    9  GLY D   25  1                                  17    
HELIX  100 AL1 SER D   30  ASP D   48  1                                  19    
HELIX  101 AL2 ASN D   53  GLN D   72  1                                  20    
HELIX  102 AL3 GLU D   75  LEU D   96  1                                  22    
HELIX  103 AL4 TYR D  126  GLY D  146  1                                  21    
HELIX  104 AL5 GLY D  146  GLN D  154  1                                   9    
HELIX  105 AL6 ALA D  155  ILE D  159  5                                   5    
HELIX  106 AL7 SER D  171  ALA D  182  1                                  12    
HELIX  107 AL8 GLN D  199  LYS D  209  1                                  11    
HELIX  108 AL9 THR D  218  ALA D  220  5                                   3    
HELIX  109 AM1 ALA D  221  MET D  226  1                                   6    
HELIX  110 AM2 SER D  227  VAL D  229  5                                   3    
HELIX  111 AM3 GLY D  250  HIS D  261  1                                  12    
HELIX  112 AM4 PRO D  296  GLU D  304  5                                   9    
HELIX  113 AM5 PRO D  317  ILE D  321  5                                   5    
HELIX  114 AM6 ALA D  332  SER D  334  5                                   3    
HELIX  115 AM7 TYR D  335  TYR D  344  1                                  10    
HELIX  116 AM8 HIS D  345  HIS D  349  5                                   5    
HELIX  117 AM9 SER E  191  MET E  196  5                                   6    
HELIX  118 AN1 HIS E  204  GLN E  216  1                                  13    
HELIX  119 AN2 GLY E  221  ASP E  239  1                                  19    
HELIX  120 AN3 GLU E  247  ARG E  267  1                                  21    
HELIX  121 AN4 SER E  270  SER E  286  1                                  17    
HELIX  122 AN5 ARG E  292  GLN E  325  1                                  34    
HELIX  123 AN6 SER E  339  GLU E  352  1                                  14    
HELIX  124 AN7 GLU E  368  ALA E  379  1                                  12    
HELIX  125 AN8 ILE E  388  LEU E  395  1                                   8    
HELIX  126 AN9 THR E  420  HIS E  430  1                                  11    
HELIX  127 AO1 GLU E  439  PHE E  443  5                                   5    
HELIX  128 AO2 ASP E  459  LEU E  463  5                                   5    
HELIX  129 AO3 PRO E  508  SER E  510  5                                   3    
HELIX  130 AO4 SER E  511  SER E  520  1                                  10    
SHEET    1 AA1 7 VAL B 119  ILE B 123  0                                        
SHEET    2 AA1 7 GLU B  90  PHE B  94  1  N  VAL B  93   O  ILE B 123           
SHEET    3 AA1 7 GLN B  44  VAL B  48  1  N  LEU B  47   O  PHE B  92           
SHEET    4 AA1 7 PHE B 148  TYR B 152  1  O  LEU B 149   N  VAL B  46           
SHEET    5 AA1 7 ILE B 251  CYS B 252 -1  O  CYS B 252   N  PHE B 148           
SHEET    6 AA1 7 SER B 179  GLU B 187 -1  N  THR B 182   O  ILE B 251           
SHEET    7 AA1 7 LEU B 244  ASP B 246 -1  O  LEU B 245   N  LYS B 186           
SHEET    1 AA2 7 VAL B 119  ILE B 123  0                                        
SHEET    2 AA2 7 GLU B  90  PHE B  94  1  N  VAL B  93   O  ILE B 123           
SHEET    3 AA2 7 GLN B  44  VAL B  48  1  N  LEU B  47   O  PHE B  92           
SHEET    4 AA2 7 PHE B 148  TYR B 152  1  O  LEU B 149   N  VAL B  46           
SHEET    5 AA2 7 ILE B 251  CYS B 252 -1  O  CYS B 252   N  PHE B 148           
SHEET    6 AA2 7 SER B 179  GLU B 187 -1  N  THR B 182   O  ILE B 251           
SHEET    7 AA2 7 GLN B 286  THR B 292  1  O  HIS B 288   N  MET B 181           
SHEET    1 AA3 2 VAL B 155  SER B 157  0                                        
SHEET    2 AA3 2 GLY B 297  ARG B 299 -1  O  ALA B 298   N  ILE B 156           
SHEET    1 AA4 3 ARG B 211  VAL B 212  0                                        
SHEET    2 AA4 3 VAL B 201  ASP B 206 -1  N  ASP B 206   O  ARG B 211           
SHEET    3 AA4 3 GLN B 216  LYS B 217 -1  O  GLN B 216   N  VAL B 202           
SHEET    1 AA5 6 ARG B 211  VAL B 212  0                                        
SHEET    2 AA5 6 VAL B 201  ASP B 206 -1  N  ASP B 206   O  ARG B 211           
SHEET    3 AA5 6 VAL B 238  ARG B 241 -1  O  ARG B 241   N  VAL B 203           
SHEET    4 AA5 6 ARG J 192  HIS J 196 -1  O  ILE J 193   N  VAL B 240           
SHEET    5 AA5 6 PHE J 157  ASP J 161 -1  N  VAL J 160   O  ARG J 194           
SHEET    6 AA5 6 LEU J 167  ALA J 171 -1  O  LEU J 168   N  GLY J 159           
SHEET    1 AA6 2 ARG B 223  PHE B 226  0                                        
SHEET    2 AA6 2 LEU J 180  LYS J 183 -1  O  LEU J 180   N  PHE B 226           
SHEET    1 AA7 8 THR B 336  HIS B 337  0                                        
SHEET    2 AA7 8 TYR B 343  ARG B 344 -1  O  ARG B 344   N  THR B 336           
SHEET    3 AA7 8 LEU B 361  LEU B 362  1  O  LEU B 362   N  TYR B 343           
SHEET    4 AA7 8 VAL B 378  ILE B 379  1  O  ILE B 379   N  LEU B 361           
SHEET    5 AA7 8 TYR B 395  LEU B 396  1  O  LEU B 396   N  VAL B 378           
SHEET    6 AA7 8 LEU B 412  LEU B 413  1  O  LEU B 413   N  TYR B 395           
SHEET    7 AA7 8 SER B 429  LEU B 431  1  O  LEU B 431   N  LEU B 412           
SHEET    8 AA7 8 SER B 447  ILE B 449  1  O  ILE B 449   N  VAL B 430           
SHEET    1 AA8 4 ILE B 355  LEU B 356  0                                        
SHEET    2 AA8 4 PHE B 373  THR B 375  1  O  ILE B 374   N  ILE B 355           
SHEET    3 AA8 4 VAL B 390  ASP B 392  1  O  LEU B 391   N  THR B 375           
SHEET    4 AA8 4 GLN B 407  HIS B 409  1  O  ILE B 408   N  VAL B 390           
SHEET    1 AA9 2 VAL B 367  ILE B 368  0                                        
SHEET    2 AA9 2 HIS B 384  ILE B 385  1  O  ILE B 385   N  VAL B 367           
SHEET    1 AB1 2 GLU B 418  VAL B 419  0                                        
SHEET    2 AB1 2 VAL B 436  VAL B 437  1  O  VAL B 437   N  GLU B 418           
SHEET    1 AB2 4 VAL J  76  ILE J  78  0                                        
SHEET    2 AB2 4 ILE J  52  VAL J  54  1  N  VAL J  53   O  VAL J  76           
SHEET    3 AB2 4 PHE J   3  MET J   8  1  N  VAL J   7   O  VAL J  54           
SHEET    4 AB2 4 ASP J 100  SER J 105  1  O  LEU J 104   N  VAL J   6           
SHEET    1 AB3 3 VAL J 200  ASP J 201  0                                        
SHEET    2 AB3 3 LEU J 128  ARG J 133 -1  N  ARG J 133   O  VAL J 200           
SHEET    3 AB3 3 ILE J 263  THR J 272  1  O  TYR J 264   N  LEU J 128           
SHEET    1 AB4 7 VAL H 175  VAL H 178  0                                        
SHEET    2 AB4 7 SER H 149  THR H 153  1  N  VAL H 152   O  VAL H 178           
SHEET    3 AB4 7 THR H 124  THR H 127  1  N  ILE H 125   O  TYR H 151           
SHEET    4 AB4 7 LEU H 192  VAL H 195  1  O  ILE H 194   N  LEU H 126           
SHEET    5 AB4 7 PHE H 226  VAL H 228  1  O  TYR H 227   N  VAL H 193           
SHEET    6 AB4 7 LEU H 283  THR H 286  1  O  LEU H 283   N  VAL H 228           
SHEET    7 AB4 7 GLY H 289  LEU H 291 -1  O  LEU H 291   N  LEU H 284           
SHEET    1 AB5 3 GLY H 199  VAL H 200  0                                        
SHEET    2 AB5 3 ILE H 206  LYS H 209 -1  O  ILE H 207   N  GLY H 199           
SHEET    3 AB5 3 VAL H 273  THR H 276 -1  O  THR H 276   N  ILE H 206           
SHEET    1 AB6 8 GLY C 329  ASN C 331  0                                        
SHEET    2 AB6 8 LEU C 323  SER C 326 -1  N  PHE C 324   O  ASN C 331           
SHEET    3 AB6 8 LEU C 265  CYS C 268  1  N  VAL C 267   O  ILE C 325           
SHEET    4 AB6 8 LYS C 231  ILE C 234  1  N  VAL C 232   O  ILE C 266           
SHEET    5 AB6 8 VAL C 164  ILE C 168  1  N  MET C 166   O  ILE C 233           
SHEET    6 AB6 8 HIS C 188  ALA C 192  1  O  ILE C 190   N  ILE C 165           
SHEET    7 AB6 8 THR C 214  MET C 217  1  O  THR C 215   N  VAL C 191           
SHEET    8 AB6 8 LEU F 482  LEU F 484  1  O  ARG F 483   N  VAL C 216           
SHEET    1 AB7 3 THR C 238  ILE C 239  0                                        
SHEET    2 AB7 3 LEU C 245  VAL C 248 -1  O  ARG C 246   N  THR C 238           
SHEET    3 AB7 3 PHE C 313  VAL C 316 -1  O  VAL C 316   N  LEU C 245           
SHEET    1 AB8 8 VAL C 306  SER C 307  0                                        
SHEET    2 AB8 8 ALA F 383  LEU F 387  1  O  ALA F 383   N  SER C 307           
SHEET    3 AB8 8 ARG F 357  ASP F 362  1  N  VAL F 360   O  SER F 384           
SHEET    4 AB8 8 VAL F 332  TYR F 336  1  N  ILE F 333   O  VAL F 359           
SHEET    5 AB8 8 LYS F 400  GLY F 404  1  O  LEU F 402   N  LEU F 334           
SHEET    6 AB8 8 VAL F 434  CYS F 437  1  O  LEU F 435   N  LEU F 403           
SHEET    7 AB8 8 LEU F 499  THR F 502  1  O  ILE F 501   N  VAL F 436           
SHEET    8 AB8 8 GLY F 505  ILE F 507 -1  O  ILE F 507   N  VAL F 500           
SHEET    1 AB9 3 ALA F 407  LEU F 408  0                                        
SHEET    2 AB9 3 VAL F 414  ARG F 417 -1  O  MET F 415   N  ALA F 407           
SHEET    3 AB9 3 TYR F 489  ASP F 490 -1  O  ASP F 490   N  SER F 416           
SHEET    1 AC1 7 VAL A 119  ILE A 123  0                                        
SHEET    2 AC1 7 GLU A  90  PHE A  94  1  N  VAL A  93   O  ILE A 123           
SHEET    3 AC1 7 GLN A  44  VAL A  48  1  N  LEU A  47   O  PHE A  92           
SHEET    4 AC1 7 PHE A 148  TYR A 152  1  O  LEU A 149   N  VAL A  46           
SHEET    5 AC1 7 ILE A 251  CYS A 252 -1  O  CYS A 252   N  PHE A 148           
SHEET    6 AC1 7 SER A 179  GLU A 187 -1  N  THR A 182   O  ILE A 251           
SHEET    7 AC1 7 LEU A 244  ASP A 246 -1  O  LEU A 245   N  LYS A 186           
SHEET    1 AC2 7 VAL A 119  ILE A 123  0                                        
SHEET    2 AC2 7 GLU A  90  PHE A  94  1  N  VAL A  93   O  ILE A 123           
SHEET    3 AC2 7 GLN A  44  VAL A  48  1  N  LEU A  47   O  PHE A  92           
SHEET    4 AC2 7 PHE A 148  TYR A 152  1  O  LEU A 149   N  VAL A  46           
SHEET    5 AC2 7 ILE A 251  CYS A 252 -1  O  CYS A 252   N  PHE A 148           
SHEET    6 AC2 7 SER A 179  GLU A 187 -1  N  THR A 182   O  ILE A 251           
SHEET    7 AC2 7 GLN A 286  THR A 292  1  O  HIS A 288   N  MET A 181           
SHEET    1 AC3 2 VAL A 155  SER A 157  0                                        
SHEET    2 AC3 2 GLY A 297  ARG A 299 -1  O  ALA A 298   N  ILE A 156           
SHEET    1 AC4 3 ARG A 211  VAL A 212  0                                        
SHEET    2 AC4 3 VAL A 201  ASP A 206 -1  N  ASP A 206   O  ARG A 211           
SHEET    3 AC4 3 GLN A 216  LYS A 217 -1  O  GLN A 216   N  VAL A 202           
SHEET    1 AC5 6 ARG A 211  VAL A 212  0                                        
SHEET    2 AC5 6 VAL A 201  ASP A 206 -1  N  ASP A 206   O  ARG A 211           
SHEET    3 AC5 6 VAL A 238  ARG A 241 -1  O  ARG A 241   N  VAL A 203           
SHEET    4 AC5 6 ARG I 192  HIS I 196 -1  O  ILE I 193   N  VAL A 240           
SHEET    5 AC5 6 PHE I 157  ASP I 161 -1  N  VAL I 160   O  ARG I 194           
SHEET    6 AC5 6 LEU I 167  ALA I 171 -1  O  LEU I 168   N  GLY I 159           
SHEET    1 AC6 2 ARG A 223  PHE A 226  0                                        
SHEET    2 AC6 2 LEU I 180  LYS I 183 -1  O  LEU I 180   N  PHE A 226           
SHEET    1 AC7 8 THR A 336  HIS A 337  0                                        
SHEET    2 AC7 8 TYR A 343  ARG A 344 -1  O  ARG A 344   N  THR A 336           
SHEET    3 AC7 8 LEU A 361  LEU A 362  1  O  LEU A 362   N  TYR A 343           
SHEET    4 AC7 8 VAL A 378  ILE A 379  1  O  ILE A 379   N  LEU A 361           
SHEET    5 AC7 8 TYR A 395  LEU A 396  1  O  LEU A 396   N  VAL A 378           
SHEET    6 AC7 8 LEU A 412  LEU A 413  1  O  LEU A 413   N  TYR A 395           
SHEET    7 AC7 8 SER A 429  LEU A 431  1  O  LEU A 431   N  LEU A 412           
SHEET    8 AC7 8 SER A 447  ILE A 449  1  O  ILE A 449   N  VAL A 430           
SHEET    1 AC8 4 ILE A 355  LEU A 356  0                                        
SHEET    2 AC8 4 PHE A 373  THR A 375  1  O  ILE A 374   N  ILE A 355           
SHEET    3 AC8 4 VAL A 390  ASP A 392  1  O  LEU A 391   N  THR A 375           
SHEET    4 AC8 4 GLN A 407  HIS A 409  1  O  ILE A 408   N  VAL A 390           
SHEET    1 AC9 2 VAL A 367  ILE A 368  0                                        
SHEET    2 AC9 2 HIS A 384  ILE A 385  1  O  ILE A 385   N  VAL A 367           
SHEET    1 AD1 2 GLU A 418  VAL A 419  0                                        
SHEET    2 AD1 2 VAL A 436  VAL A 437  1  O  VAL A 437   N  GLU A 418           
SHEET    1 AD2 4 VAL I  76  ILE I  78  0                                        
SHEET    2 AD2 4 ILE I  52  VAL I  54  1  N  VAL I  53   O  VAL I  76           
SHEET    3 AD2 4 PHE I   3  MET I   8  1  N  VAL I   7   O  VAL I  54           
SHEET    4 AD2 4 ASP I 100  SER I 105  1  O  LEU I 104   N  VAL I   6           
SHEET    1 AD3 3 VAL I 200  ASP I 201  0                                        
SHEET    2 AD3 3 LEU I 128  ARG I 133 -1  N  ARG I 133   O  VAL I 200           
SHEET    3 AD3 3 ILE I 263  PHE I 266  1  O  TYR I 264   N  LEU I 128           
SHEET    1 AD4 7 VAL G 175  VAL G 178  0                                        
SHEET    2 AD4 7 SER G 149  THR G 153  1  N  VAL G 152   O  VAL G 178           
SHEET    3 AD4 7 THR G 124  THR G 127  1  N  ILE G 125   O  TYR G 151           
SHEET    4 AD4 7 LEU G 192  VAL G 195  1  O  ILE G 194   N  LEU G 126           
SHEET    5 AD4 7 PHE G 226  VAL G 228  1  O  TYR G 227   N  VAL G 193           
SHEET    6 AD4 7 LEU G 283  THR G 286  1  O  LEU G 283   N  VAL G 228           
SHEET    7 AD4 7 GLY G 289  LEU G 291 -1  O  LEU G 291   N  LEU G 284           
SHEET    1 AD5 3 GLY G 199  VAL G 200  0                                        
SHEET    2 AD5 3 ILE G 206  LYS G 209 -1  O  ILE G 207   N  GLY G 199           
SHEET    3 AD5 3 VAL G 273  THR G 276 -1  O  THR G 276   N  ILE G 206           
SHEET    1 AD6 8 GLY D 329  ASN D 331  0                                        
SHEET    2 AD6 8 LEU D 323  SER D 326 -1  N  PHE D 324   O  ASN D 331           
SHEET    3 AD6 8 LEU D 265  CYS D 268  1  N  VAL D 267   O  ILE D 325           
SHEET    4 AD6 8 LYS D 231  ILE D 234  1  N  VAL D 232   O  ILE D 266           
SHEET    5 AD6 8 VAL D 164  ILE D 168  1  N  MET D 166   O  ILE D 233           
SHEET    6 AD6 8 HIS D 188  ALA D 192  1  O  ILE D 190   N  ILE D 165           
SHEET    7 AD6 8 THR D 214  MET D 217  1  O  THR D 215   N  VAL D 191           
SHEET    8 AD6 8 LEU E 482  LEU E 484  1  O  ARG E 483   N  VAL D 216           
SHEET    1 AD7 3 THR D 238  ILE D 239  0                                        
SHEET    2 AD7 3 LEU D 245  VAL D 248 -1  O  ARG D 246   N  THR D 238           
SHEET    3 AD7 3 PHE D 313  VAL D 316 -1  O  VAL D 316   N  LEU D 245           
SHEET    1 AD8 8 VAL D 306  SER D 307  0                                        
SHEET    2 AD8 8 ALA E 383  LEU E 387  1  O  ALA E 383   N  SER D 307           
SHEET    3 AD8 8 ARG E 357  ASP E 362  1  N  VAL E 360   O  SER E 384           
SHEET    4 AD8 8 VAL E 332  TYR E 336  1  N  ILE E 333   O  VAL E 359           
SHEET    5 AD8 8 LYS E 400  GLY E 404  1  O  LEU E 402   N  LEU E 334           
SHEET    6 AD8 8 VAL E 434  CYS E 437  1  O  LEU E 435   N  LEU E 403           
SHEET    7 AD8 8 LEU E 499  THR E 502  1  O  ILE E 501   N  VAL E 436           
SHEET    8 AD8 8 GLY E 505  ILE E 507 -1  O  ILE E 507   N  VAL E 500           
SHEET    1 AD9 3 ALA E 407  LEU E 408  0                                        
SHEET    2 AD9 3 VAL E 414  ARG E 417 -1  O  MET E 415   N  ALA E 407           
SHEET    3 AD9 3 TYR E 489  ASP E 490 -1  O  ASP E 490   N  SER E 416           
LINK         CD2 PHE I 266                 CG2 THR I 272     1555   1555  1.47  
LINK         CE2 PHE I 266                 CG2 THR I 272     1555   1555  1.47  
CISPEP   1 PHE B   57    PRO B   58          0        -6.83                     
CISPEP   2 TYR B  319    PRO B  320          0         6.83                     
CISPEP   3 GLY C   27    PRO C   28          0        -0.18                     
CISPEP   4 ARG F  364    PRO F  365          0        -6.29                     
CISPEP   5 PHE A   57    PRO A   58          0        -6.67                     
CISPEP   6 TYR A  319    PRO A  320          0         6.81                     
CISPEP   7 GLY D   27    PRO D   28          0        -0.24                     
CISPEP   8 ARG E  364    PRO E  365          0        -6.15                     
SITE     1 AC1 16 ASN C 162  VAL C 164  HIS C 188  ILE C 190                    
SITE     2 AC1 16 MET C 217  VAL C 225  ASN D 162  VAL D 164                    
SITE     3 AC1 16 HIS D 188  ILE D 190  MET D 217  VAL D 225                    
SITE     4 AC1 16 VAL E 177  LEU E 179  VAL F 177  LEU F 179                    
SITE     1 AC2  9 GLU I 116  LEU I 120  MET I 130  LEU I 131                    
SITE     2 AC2  9 MET I 132  LYS I 134  SER I 265  ILE I 267                    
SITE     3 AC2  9 LEU I 273                                                     
SITE     1 AC3  9 GLU I 116  LEU I 120  MET I 130  LEU I 131                    
SITE     2 AC3  9 MET I 132  LYS I 134  SER I 265  ILE I 267                    
SITE     3 AC3  9 LEU I 273                                                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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