GenomeNet

Database: PDB
Entry: 6CRI
LinkDB: 6CRI
Original site: 6CRI 
HEADER    VIRAL PROTEIN, PROTEIN TRANSPORT        18-MAR-18   6CRI              
TITLE     STRUCTURE OF THE CARGO BOUND AP-1:ARF1:TETHERIN-NEF STABLE CLOSED     
TITLE    2 TRIMER                                                               
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: BONE MARROW STROMAL ANTIGEN 2, PROTEIN NEF CHIMERA;        
COMPND   3 CHAIN: T, N, c, Y, d, Z;                                             
COMPND   4 FRAGMENT: TETHERIN UNP RESIDUES 2-26, NEF UNP RESIDUES 1-206;        
COMPND   5 SYNONYM: BST-2, HM1.24 ANTIGEN, TETHERIN;                            
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: AP-1 COMPLEX SUBUNIT BETA-1;                               
COMPND   9 CHAIN: B, I, J;                                                      
COMPND  10 SYNONYM: ADAPTOR PROTEIN COMPLEX AP-1 SUBUNIT BETA-1, ADAPTOR-RELATED
COMPND  11 PROTEIN COMPLEX 1 SUBUNIT BETA-1, BETA-1-ADAPTIN, BETA-ADAPTIN 1,    
COMPND  12 CLATHRIN ASSEMBLY PROTEIN COMPLEX 1 BETA LARGE CHAIN, GOLGI ADAPTOR  
COMPND  13 HA1/AP1 ADAPTIN BETA SUBUNIT;                                        
COMPND  14 ENGINEERED: YES;                                                     
COMPND  15 MUTATION: YES;                                                       
COMPND  16 MOL_ID: 3;                                                           
COMPND  17 MOLECULE: ADP-RIBOSYLATION FACTOR 1;                                 
COMPND  18 CHAIN: C, H, K, U, L, V;                                             
COMPND  19 SYNONYM: ARF1;                                                       
COMPND  20 ENGINEERED: YES;                                                     
COMPND  21 MUTATION: YES;                                                       
COMPND  22 MOL_ID: 4;                                                           
COMPND  23 MOLECULE: AP-1 COMPLEX SUBUNIT GAMMA-1;                              
COMPND  24 CHAIN: G, Q, R;                                                      
COMPND  25 SYNONYM: ADAPTOR PROTEIN COMPLEX AP-1 SUBUNIT GAMMA-1, ADAPTOR-      
COMPND  26 RELATED PROTEIN COMPLEX 1 SUBUNIT GAMMA-1, CLATHRIN ASSEMBLY PROTEIN 
COMPND  27 COMPLEX 1 GAMMA-1 LARGE CHAIN, GAMMA-ADAPTIN, GAMMA1-ADAPTIN, GOLGI  
COMPND  28 ADAPTOR HA1/AP1 ADAPTIN SUBUNIT GAMMA-1;                             
COMPND  29 ENGINEERED: YES;                                                     
COMPND  30 MOL_ID: 5;                                                           
COMPND  31 MOLECULE: AP-1 COMPLEX SUBUNIT MU-1;                                 
COMPND  32 CHAIN: M, W, X;                                                      
COMPND  33 SYNONYM: AP-MU CHAIN FAMILY MEMBER MU1A, ADAPTOR PROTEIN COMPLEX AP-1
COMPND  34 SUBUNIT MU-1, ADAPTOR-RELATED PROTEIN COMPLEX 1 SUBUNIT MU-1,        
COMPND  35 CLATHRIN ASSEMBLY PROTEIN COMPLEX 1 MU-1 MEDIUM CHAIN 1, CLATHRIN    
COMPND  36 COAT ASSEMBLY PROTEIN AP47, CLATHRIN COAT-ASSOCIATED PROTEIN AP47,   
COMPND  37 GOLGI ADAPTOR HA1/AP1 ADAPTIN MU-1 SUBUNIT, MU-ADAPTIN 1, MU1A-      
COMPND  38 ADAPTIN;                                                             
COMPND  39 ENGINEERED: YES;                                                     
COMPND  40 MOL_ID: 6;                                                           
COMPND  41 MOLECULE: AP-1 COMPLEX SUBUNIT SIGMA-3;                              
COMPND  42 CHAIN: S, a, b;                                                      
COMPND  43 SYNONYM: ADAPTOR PROTEIN COMPLEX AP-1 SUBUNIT SIGMA-1C, ADAPTOR-     
COMPND  44 RELATED PROTEIN COMPLEX 1 SUBUNIT SIGMA-1C, CLATHRIN ASSEMBLY PROTEIN
COMPND  45 COMPLEX 1 SIGMA-1C SMALL CHAIN, GOLGI ADAPTOR HA1/AP1 ADAPTIN SIGMA- 
COMPND  46 1C SUBUNIT, SIGMA 1C SUBUNIT OF AP-1 CLATHRIN, SIGMA-ADAPTIN 1C,     
COMPND  47 SIGMA1C-ADAPTIN;                                                     
COMPND  48 ENGINEERED: YES;                                                     
COMPND  49 MUTATION: YES                                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS, HUMAN IMMUNODEFICIENCY VIRUS 1;   
SOURCE   3 ORGANISM_COMMON: HUMAN, HIV-1;                                       
SOURCE   4 ORGANISM_TAXID: 9606, 11676;                                         
SOURCE   5 GENE: BST2, NEF;                                                     
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: AP1B1, ADTB1, BAM22, CLAPB2;                                   
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 GENE: ARF1;                                                          
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  24 ORGANISM_COMMON: MOUSE;                                              
SOURCE  25 ORGANISM_TAXID: 10090;                                               
SOURCE  26 GENE: AP1G1, ADTG, CLAPG1;                                           
SOURCE  27 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  28 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  29 MOL_ID: 5;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  31 ORGANISM_COMMON: MOUSE;                                              
SOURCE  32 ORGANISM_TAXID: 10090;                                               
SOURCE  33 GENE: AP1M1, CLTNM;                                                  
SOURCE  34 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  35 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  36 MOL_ID: 6;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  38 ORGANISM_COMMON: HUMAN;                                              
SOURCE  39 ORGANISM_TAXID: 9606;                                                
SOURCE  40 GENE: AP1S3;                                                         
SOURCE  41 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  42 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    AP, HIV, NEF, TRAFFICKING, VIRAL PROTEIN, PROTEIN TRANSPORT           
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    K.L.MORRIS,C.Z.BUFFALO,J.H.HURLEY                                     
REVDAT   3   18-DEC-19 6CRI    1       REMARK                                   
REVDAT   2   08-AUG-18 6CRI    1       JRNL                                     
REVDAT   1   01-AUG-18 6CRI    0                                                
JRNL        AUTH   K.L.MORRIS,C.Z.BUFFALO,C.M.STURZEL,E.HEUSINGER,F.KIRCHHOFF,  
JRNL        AUTH 2 X.REN,J.H.HURLEY                                             
JRNL        TITL   HIV-1 NEFS ARE CARGO-SENSITIVE AP-1 TRIMERIZATION SWITCHES   
JRNL        TITL 2 IN TETHERIN DOWNREGULATION.                                  
JRNL        REF    CELL                          V. 174   659 2018              
JRNL        REFN                   ISSN 1097-4172                               
JRNL        PMID   30053425                                                     
JRNL        DOI    10.1016/J.CELL.2018.07.004                                   
REMARK   2                                                                      
REMARK   2 RESOLUTION.    6.80 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION, RELION, RELION                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : CORRELATION COEFFICIENT             
REMARK   3   OVERALL ANISOTROPIC B VALUE  : 425.000                             
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 6.800                          
REMARK   3   NUMBER OF PARTICLES               : 11108                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6CRI COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 19-MAR-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000233260.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : STRUCTURE OF THE CARGO BOUND AP   
REMARK 245                                    -1:ARF1:TETHERIN-NEF STABLE       
REMARK 245                                    CLOSED TRIMER                     
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.07                              
REMARK 245   SAMPLE SUPPORT DETAILS         : UNSPECIFIED                       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 62.40                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 24-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: T, B, C, G, H, M, S, N, c, I,         
REMARK 350                    AND CHAINS: K, Q, U, W, a, Y, d, J, L,            
REMARK 350                    AND CHAINS: R, V, X, b, Z                         
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET T   -26                                                      
REMARK 465     SER T   -25                                                      
REMARK 465     TYR T   -24                                                      
REMARK 465     TYR T   -23                                                      
REMARK 465     HIS T   -22                                                      
REMARK 465     HIS T   -21                                                      
REMARK 465     HIS T   -20                                                      
REMARK 465     HIS T   -19                                                      
REMARK 465     HIS T   -18                                                      
REMARK 465     HIS T   -17                                                      
REMARK 465     ASP T   -16                                                      
REMARK 465     TYR T   -15                                                      
REMARK 465     ASP T   -14                                                      
REMARK 465     ILE T   -13                                                      
REMARK 465     PRO T   -12                                                      
REMARK 465     THR T   -11                                                      
REMARK 465     THR T   -10                                                      
REMARK 465     GLU T    -9                                                      
REMARK 465     ASN T    -8                                                      
REMARK 465     LEU T    -7                                                      
REMARK 465     TYR T    -6                                                      
REMARK 465     PHE T    -5                                                      
REMARK 465     GLN T    -4                                                      
REMARK 465     GLY T    -3                                                      
REMARK 465     ALA T    -2                                                      
REMARK 465     MET T    -1                                                      
REMARK 465     GLY T     0                                                      
REMARK 465     SER T     1                                                      
REMARK 465     ALA T     2                                                      
REMARK 465     SER T     3                                                      
REMARK 465     ASP T    17                                                      
REMARK 465     LYS T    18                                                      
REMARK 465     ARG T    19                                                      
REMARK 465     CYS T    20                                                      
REMARK 465     LYS T    21                                                      
REMARK 465     GLY T    22                                                      
REMARK 465     SER T    23                                                      
REMARK 465     ASP T    24                                                      
REMARK 465     GLU T    25                                                      
REMARK 465     ALA T    26                                                      
REMARK 465     SER T    27                                                      
REMARK 465     GLU T    28                                                      
REMARK 465     GLY T    29                                                      
REMARK 465     SER T    30                                                      
REMARK 465     GLY T    31                                                      
REMARK 465     MET T    32                                                      
REMARK 465     GLY T    33                                                      
REMARK 465     GLY T    34                                                      
REMARK 465     LYS T    35                                                      
REMARK 465     TRP T    36                                                      
REMARK 465     SER T    37                                                      
REMARK 465     LYS T    38                                                      
REMARK 465     SER T    39                                                      
REMARK 465     SER T    40                                                      
REMARK 465     VAL T    41                                                      
REMARK 465     ILE T    42                                                      
REMARK 465     GLY T    43                                                      
REMARK 465     TRP T    44                                                      
REMARK 465     PRO T    45                                                      
REMARK 465     ALA T    46                                                      
REMARK 465     VAL T    47                                                      
REMARK 465     ARG T    48                                                      
REMARK 465     GLU T    49                                                      
REMARK 465     ARG T    50                                                      
REMARK 465     MET T    51                                                      
REMARK 465     ARG T    52                                                      
REMARK 465     ARG T    53                                                      
REMARK 465     ALA T    54                                                      
REMARK 465     GLU T    55                                                      
REMARK 465     PRO T    56                                                      
REMARK 465     ALA T    57                                                      
REMARK 465     ALA T    58                                                      
REMARK 465     ASP T    59                                                      
REMARK 465     GLY T    60                                                      
REMARK 465     VAL T    61                                                      
REMARK 465     GLY T    62                                                      
REMARK 465     ALA T    63                                                      
REMARK 465     VAL T    64                                                      
REMARK 465     SER T    65                                                      
REMARK 465     ARG T    66                                                      
REMARK 465     ASP T    67                                                      
REMARK 465     LEU T    68                                                      
REMARK 465     GLU T    69                                                      
REMARK 465     LYS T    70                                                      
REMARK 465     HIS T    71                                                      
REMARK 465     GLY T    72                                                      
REMARK 465     ALA T    73                                                      
REMARK 465     ILE T    74                                                      
REMARK 465     THR T    75                                                      
REMARK 465     SER T    76                                                      
REMARK 465     SER T    77                                                      
REMARK 465     ASN T    78                                                      
REMARK 465     THR T    79                                                      
REMARK 465     ALA T    80                                                      
REMARK 465     ALA T    81                                                      
REMARK 465     ASN T    82                                                      
REMARK 465     ASN T    83                                                      
REMARK 465     ALA T    84                                                      
REMARK 465     ALA T    85                                                      
REMARK 465     CYS T    86                                                      
REMARK 465     ALA T    87                                                      
REMARK 465     TRP T    88                                                      
REMARK 465     LEU T    89                                                      
REMARK 465     GLU T    90                                                      
REMARK 465     ALA T    91                                                      
REMARK 465     GLN T    92                                                      
REMARK 465     GLU T    93                                                      
REMARK 465     GLU T    94                                                      
REMARK 465     GLU T    95                                                      
REMARK 465     GLU T    96                                                      
REMARK 465     VAL T    97                                                      
REMARK 465     GLY T    98                                                      
REMARK 465     PHE T    99                                                      
REMARK 465     PRO T   100                                                      
REMARK 465     VAL T   101                                                      
REMARK 465     THR T   102                                                      
REMARK 465     PRO T   103                                                      
REMARK 465     GLN T   104                                                      
REMARK 465     VAL T   105                                                      
REMARK 465     PRO T   106                                                      
REMARK 465     LEU T   107                                                      
REMARK 465     ARG T   108                                                      
REMARK 465     PRO T   109                                                      
REMARK 465     MET T   110                                                      
REMARK 465     THR T   111                                                      
REMARK 465     TYR T   112                                                      
REMARK 465     LYS T   113                                                      
REMARK 465     ALA T   114                                                      
REMARK 465     ALA T   115                                                      
REMARK 465     VAL T   116                                                      
REMARK 465     ASP T   117                                                      
REMARK 465     LEU T   118                                                      
REMARK 465     SER T   119                                                      
REMARK 465     HIS T   120                                                      
REMARK 465     PHE T   121                                                      
REMARK 465     LEU T   122                                                      
REMARK 465     LYS T   123                                                      
REMARK 465     GLU T   124                                                      
REMARK 465     LYS T   125                                                      
REMARK 465     GLY T   126                                                      
REMARK 465     GLY T   127                                                      
REMARK 465     LEU T   128                                                      
REMARK 465     GLU T   129                                                      
REMARK 465     GLY T   130                                                      
REMARK 465     LEU T   131                                                      
REMARK 465     ILE T   132                                                      
REMARK 465     HIS T   133                                                      
REMARK 465     SER T   134                                                      
REMARK 465     GLN T   135                                                      
REMARK 465     ARG T   136                                                      
REMARK 465     ARG T   137                                                      
REMARK 465     GLN T   138                                                      
REMARK 465     ASP T   139                                                      
REMARK 465     ILE T   140                                                      
REMARK 465     LEU T   141                                                      
REMARK 465     ASP T   142                                                      
REMARK 465     LEU T   143                                                      
REMARK 465     TRP T   144                                                      
REMARK 465     ILE T   145                                                      
REMARK 465     TYR T   146                                                      
REMARK 465     HIS T   147                                                      
REMARK 465     THR T   148                                                      
REMARK 465     GLN T   149                                                      
REMARK 465     GLY T   150                                                      
REMARK 465     TYR T   151                                                      
REMARK 465     PHE T   152                                                      
REMARK 465     PRO T   153                                                      
REMARK 465     ASP T   154                                                      
REMARK 465     TRP T   155                                                      
REMARK 465     GLN T   156                                                      
REMARK 465     ASN T   157                                                      
REMARK 465     TYR T   158                                                      
REMARK 465     THR T   159                                                      
REMARK 465     PRO T   160                                                      
REMARK 465     GLY T   161                                                      
REMARK 465     PRO T   162                                                      
REMARK 465     GLY T   163                                                      
REMARK 465     VAL T   164                                                      
REMARK 465     ARG T   165                                                      
REMARK 465     TYR T   166                                                      
REMARK 465     PRO T   167                                                      
REMARK 465     LEU T   168                                                      
REMARK 465     THR T   169                                                      
REMARK 465     PHE T   170                                                      
REMARK 465     GLY T   171                                                      
REMARK 465     TRP T   172                                                      
REMARK 465     CYS T   173                                                      
REMARK 465     TYR T   174                                                      
REMARK 465     LYS T   175                                                      
REMARK 465     LEU T   176                                                      
REMARK 465     VAL T   177                                                      
REMARK 465     PRO T   178                                                      
REMARK 465     VAL T   179                                                      
REMARK 465     GLU T   180                                                      
REMARK 465     PRO T   181                                                      
REMARK 465     ASP T   182                                                      
REMARK 465     LYS T   183                                                      
REMARK 465     VAL T   184                                                      
REMARK 465     GLU T   185                                                      
REMARK 465     GLU T   186                                                      
REMARK 465     ALA T   187                                                      
REMARK 465     ASN T   188                                                      
REMARK 465     LYS T   189                                                      
REMARK 465     GLY T   190                                                      
REMARK 465     GLU T   191                                                      
REMARK 465     ASN T   192                                                      
REMARK 465     THR T   193                                                      
REMARK 465     SER T   194                                                      
REMARK 465     LEU T   195                                                      
REMARK 465     LEU T   196                                                      
REMARK 465     HIS T   197                                                      
REMARK 465     PRO T   198                                                      
REMARK 465     VAL T   199                                                      
REMARK 465     SER T   200                                                      
REMARK 465     LEU T   201                                                      
REMARK 465     HIS T   202                                                      
REMARK 465     GLY T   203                                                      
REMARK 465     MET T   204                                                      
REMARK 465     ASP T   205                                                      
REMARK 465     ASP T   206                                                      
REMARK 465     PRO T   207                                                      
REMARK 465     GLU T   208                                                      
REMARK 465     ARG T   209                                                      
REMARK 465     GLU T   210                                                      
REMARK 465     VAL T   211                                                      
REMARK 465     LEU T   212                                                      
REMARK 465     GLU T   213                                                      
REMARK 465     TRP T   214                                                      
REMARK 465     ARG T   215                                                      
REMARK 465     PHE T   216                                                      
REMARK 465     ASP T   217                                                      
REMARK 465     SER T   218                                                      
REMARK 465     ARG T   219                                                      
REMARK 465     LEU T   220                                                      
REMARK 465     ALA T   221                                                      
REMARK 465     PHE T   222                                                      
REMARK 465     HIS T   223                                                      
REMARK 465     HIS T   224                                                      
REMARK 465     VAL T   225                                                      
REMARK 465     ALA T   226                                                      
REMARK 465     ARG T   227                                                      
REMARK 465     GLU T   228                                                      
REMARK 465     LEU T   229                                                      
REMARK 465     HIS T   230                                                      
REMARK 465     PRO T   231                                                      
REMARK 465     GLU T   232                                                      
REMARK 465     TYR T   233                                                      
REMARK 465     PHE T   234                                                      
REMARK 465     LYS T   235                                                      
REMARK 465     ASN T   236                                                      
REMARK 465     CYS T   237                                                      
REMARK 465     GLN H   180                                                      
REMARK 465     LYS H   181                                                      
REMARK 465     GLY M   139                                                      
REMARK 465     HIS M   140                                                      
REMARK 465     LYS M   141                                                      
REMARK 465     LEU M   142                                                      
REMARK 465     GLU M   143                                                      
REMARK 465     THR M   144                                                      
REMARK 465     GLY M   145                                                      
REMARK 465     MET N   -57                                                      
REMARK 465     SER N   -56                                                      
REMARK 465     TYR N   -55                                                      
REMARK 465     TYR N   -54                                                      
REMARK 465     HIS N   -53                                                      
REMARK 465     HIS N   -52                                                      
REMARK 465     HIS N   -51                                                      
REMARK 465     HIS N   -50                                                      
REMARK 465     HIS N   -49                                                      
REMARK 465     HIS N   -48                                                      
REMARK 465     ASP N   -47                                                      
REMARK 465     TYR N   -46                                                      
REMARK 465     ASP N   -45                                                      
REMARK 465     ILE N   -44                                                      
REMARK 465     PRO N   -43                                                      
REMARK 465     THR N   -42                                                      
REMARK 465     THR N   -41                                                      
REMARK 465     GLU N   -40                                                      
REMARK 465     ASN N   -39                                                      
REMARK 465     LEU N   -38                                                      
REMARK 465     TYR N   -37                                                      
REMARK 465     PHE N   -36                                                      
REMARK 465     GLN N   -35                                                      
REMARK 465     GLY N   -34                                                      
REMARK 465     ALA N   -33                                                      
REMARK 465     MET N   -32                                                      
REMARK 465     GLY N   -31                                                      
REMARK 465     SER N   -30                                                      
REMARK 465     ALA N   -29                                                      
REMARK 465     SER N   -28                                                      
REMARK 465     THR N   -27                                                      
REMARK 465     SER N   -26                                                      
REMARK 465     TYR N   -25                                                      
REMARK 465     ASP N   -24                                                      
REMARK 465     TYR N   -23                                                      
REMARK 465     CYS N   -22                                                      
REMARK 465     ARG N   -21                                                      
REMARK 465     VAL N   -20                                                      
REMARK 465     PRO N   -19                                                      
REMARK 465     MET N   -18                                                      
REMARK 465     GLU N   -17                                                      
REMARK 465     ASP N   -16                                                      
REMARK 465     GLY N   -15                                                      
REMARK 465     ASP N   -14                                                      
REMARK 465     LYS N   -13                                                      
REMARK 465     ARG N   -12                                                      
REMARK 465     CYS N   -11                                                      
REMARK 465     LYS N   -10                                                      
REMARK 465     GLY N    -9                                                      
REMARK 465     SER N    -8                                                      
REMARK 465     ASP N    -7                                                      
REMARK 465     GLU N    -6                                                      
REMARK 465     ALA N    -5                                                      
REMARK 465     SER N    -4                                                      
REMARK 465     GLU N    -3                                                      
REMARK 465     GLY N    -2                                                      
REMARK 465     SER N    -1                                                      
REMARK 465     GLY N     0                                                      
REMARK 465     MET N     1                                                      
REMARK 465     GLY N     2                                                      
REMARK 465     GLY N     3                                                      
REMARK 465     LYS N     4                                                      
REMARK 465     TRP N     5                                                      
REMARK 465     ALA N    27                                                      
REMARK 465     ASP N    28                                                      
REMARK 465     GLY N    29                                                      
REMARK 465     VAL N    30                                                      
REMARK 465     GLY N    31                                                      
REMARK 465     ALA N    32                                                      
REMARK 465     VAL N    33                                                      
REMARK 465     SER N    34                                                      
REMARK 465     ARG N    35                                                      
REMARK 465     ASP N    36                                                      
REMARK 465     LEU N    37                                                      
REMARK 465     GLU N    38                                                      
REMARK 465     LYS N    39                                                      
REMARK 465     HIS N    40                                                      
REMARK 465     GLY N    41                                                      
REMARK 465     ALA N    42                                                      
REMARK 465     ILE N    43                                                      
REMARK 465     THR N    44                                                      
REMARK 465     SER N    45                                                      
REMARK 465     SER N    46                                                      
REMARK 465     ASN N    47                                                      
REMARK 465     THR N    48                                                      
REMARK 465     ALA N    49                                                      
REMARK 465     ALA N    50                                                      
REMARK 465     ASN N    51                                                      
REMARK 465     ASN N    52                                                      
REMARK 465     ALA N    53                                                      
REMARK 465     ALA N    54                                                      
REMARK 465     CYS N    55                                                      
REMARK 465     ALA N    56                                                      
REMARK 465     TRP N    57                                                      
REMARK 465     LEU N    58                                                      
REMARK 465     GLU N    59                                                      
REMARK 465     ALA N    60                                                      
REMARK 465     GLN N    61                                                      
REMARK 465     GLU N    62                                                      
REMARK 465     GLU N    63                                                      
REMARK 465     GLU N   149                                                      
REMARK 465     PRO N   150                                                      
REMARK 465     ASP N   151                                                      
REMARK 465     LYS N   152                                                      
REMARK 465     VAL N   153                                                      
REMARK 465     GLU N   154                                                      
REMARK 465     GLU N   155                                                      
REMARK 465     ALA N   156                                                      
REMARK 465     ASN N   157                                                      
REMARK 465     VAL N   168                                                      
REMARK 465     SER N   169                                                      
REMARK 465     LEU N   170                                                      
REMARK 465     HIS N   171                                                      
REMARK 465     GLY N   172                                                      
REMARK 465     MET N   173                                                      
REMARK 465     ASP N   174                                                      
REMARK 465     ASP N   175                                                      
REMARK 465     PRO N   176                                                      
REMARK 465     GLU N   177                                                      
REMARK 465     ARG N   178                                                      
REMARK 465     GLU N   179                                                      
REMARK 465     ASN N   205                                                      
REMARK 465     CYS N   206                                                      
REMARK 465     MET c   -26                                                      
REMARK 465     SER c   -25                                                      
REMARK 465     TYR c   -24                                                      
REMARK 465     TYR c   -23                                                      
REMARK 465     HIS c   -22                                                      
REMARK 465     HIS c   -21                                                      
REMARK 465     HIS c   -20                                                      
REMARK 465     HIS c   -19                                                      
REMARK 465     HIS c   -18                                                      
REMARK 465     HIS c   -17                                                      
REMARK 465     ASP c   -16                                                      
REMARK 465     TYR c   -15                                                      
REMARK 465     ASP c   -14                                                      
REMARK 465     ILE c   -13                                                      
REMARK 465     PRO c   -12                                                      
REMARK 465     THR c   -11                                                      
REMARK 465     THR c   -10                                                      
REMARK 465     GLU c    -9                                                      
REMARK 465     ASN c    -8                                                      
REMARK 465     LEU c    -7                                                      
REMARK 465     TYR c    -6                                                      
REMARK 465     PHE c    -5                                                      
REMARK 465     GLN c    -4                                                      
REMARK 465     GLY c    -3                                                      
REMARK 465     ALA c    -2                                                      
REMARK 465     MET c    -1                                                      
REMARK 465     GLY c     0                                                      
REMARK 465     SER c     1                                                      
REMARK 465     ALA c     2                                                      
REMARK 465     SER c     3                                                      
REMARK 465     ASP c    17                                                      
REMARK 465     LYS c    18                                                      
REMARK 465     ARG c    19                                                      
REMARK 465     CYS c    20                                                      
REMARK 465     LYS c    21                                                      
REMARK 465     GLY c    22                                                      
REMARK 465     SER c    23                                                      
REMARK 465     ASP c    24                                                      
REMARK 465     GLU c    25                                                      
REMARK 465     ALA c    26                                                      
REMARK 465     SER c    27                                                      
REMARK 465     GLU c    28                                                      
REMARK 465     GLY c    29                                                      
REMARK 465     SER c    30                                                      
REMARK 465     GLY c    31                                                      
REMARK 465     MET c    32                                                      
REMARK 465     GLY c    33                                                      
REMARK 465     GLY c    34                                                      
REMARK 465     LYS c    35                                                      
REMARK 465     TRP c    36                                                      
REMARK 465     SER c    37                                                      
REMARK 465     LYS c    38                                                      
REMARK 465     SER c    39                                                      
REMARK 465     SER c    40                                                      
REMARK 465     VAL c    41                                                      
REMARK 465     ILE c    42                                                      
REMARK 465     GLY c    43                                                      
REMARK 465     TRP c    44                                                      
REMARK 465     PRO c    45                                                      
REMARK 465     ALA c    46                                                      
REMARK 465     VAL c    47                                                      
REMARK 465     ARG c    48                                                      
REMARK 465     GLU c    49                                                      
REMARK 465     ARG c    50                                                      
REMARK 465     MET c    51                                                      
REMARK 465     ARG c    52                                                      
REMARK 465     ARG c    53                                                      
REMARK 465     ALA c    54                                                      
REMARK 465     GLU c    55                                                      
REMARK 465     PRO c    56                                                      
REMARK 465     ALA c    57                                                      
REMARK 465     ALA c    58                                                      
REMARK 465     ASP c    59                                                      
REMARK 465     GLY c    60                                                      
REMARK 465     VAL c    61                                                      
REMARK 465     GLY c    62                                                      
REMARK 465     ALA c    63                                                      
REMARK 465     VAL c    64                                                      
REMARK 465     SER c    65                                                      
REMARK 465     ARG c    66                                                      
REMARK 465     ASP c    67                                                      
REMARK 465     LEU c    68                                                      
REMARK 465     GLU c    69                                                      
REMARK 465     LYS c    70                                                      
REMARK 465     HIS c    71                                                      
REMARK 465     GLY c    72                                                      
REMARK 465     ALA c    73                                                      
REMARK 465     ILE c    74                                                      
REMARK 465     THR c    75                                                      
REMARK 465     SER c    76                                                      
REMARK 465     SER c    77                                                      
REMARK 465     ASN c    78                                                      
REMARK 465     THR c    79                                                      
REMARK 465     ALA c    80                                                      
REMARK 465     ALA c    81                                                      
REMARK 465     ASN c    82                                                      
REMARK 465     ASN c    83                                                      
REMARK 465     ALA c    84                                                      
REMARK 465     ALA c    85                                                      
REMARK 465     CYS c    86                                                      
REMARK 465     ALA c    87                                                      
REMARK 465     TRP c    88                                                      
REMARK 465     LEU c    89                                                      
REMARK 465     GLU c    90                                                      
REMARK 465     ALA c    91                                                      
REMARK 465     GLN c    92                                                      
REMARK 465     GLU c    93                                                      
REMARK 465     GLU c    94                                                      
REMARK 465     GLU c    95                                                      
REMARK 465     GLU c    96                                                      
REMARK 465     VAL c    97                                                      
REMARK 465     GLY c    98                                                      
REMARK 465     PHE c    99                                                      
REMARK 465     PRO c   100                                                      
REMARK 465     VAL c   101                                                      
REMARK 465     THR c   102                                                      
REMARK 465     PRO c   103                                                      
REMARK 465     GLN c   104                                                      
REMARK 465     VAL c   105                                                      
REMARK 465     PRO c   106                                                      
REMARK 465     LEU c   107                                                      
REMARK 465     ARG c   108                                                      
REMARK 465     PRO c   109                                                      
REMARK 465     MET c   110                                                      
REMARK 465     THR c   111                                                      
REMARK 465     TYR c   112                                                      
REMARK 465     LYS c   113                                                      
REMARK 465     ALA c   114                                                      
REMARK 465     ALA c   115                                                      
REMARK 465     VAL c   116                                                      
REMARK 465     ASP c   117                                                      
REMARK 465     LEU c   118                                                      
REMARK 465     SER c   119                                                      
REMARK 465     HIS c   120                                                      
REMARK 465     PHE c   121                                                      
REMARK 465     LEU c   122                                                      
REMARK 465     LYS c   123                                                      
REMARK 465     GLU c   124                                                      
REMARK 465     LYS c   125                                                      
REMARK 465     GLY c   126                                                      
REMARK 465     GLY c   127                                                      
REMARK 465     LEU c   128                                                      
REMARK 465     GLU c   129                                                      
REMARK 465     GLY c   130                                                      
REMARK 465     LEU c   131                                                      
REMARK 465     ILE c   132                                                      
REMARK 465     HIS c   133                                                      
REMARK 465     SER c   134                                                      
REMARK 465     GLN c   135                                                      
REMARK 465     ARG c   136                                                      
REMARK 465     ARG c   137                                                      
REMARK 465     GLN c   138                                                      
REMARK 465     ASP c   139                                                      
REMARK 465     ILE c   140                                                      
REMARK 465     LEU c   141                                                      
REMARK 465     ASP c   142                                                      
REMARK 465     LEU c   143                                                      
REMARK 465     TRP c   144                                                      
REMARK 465     ILE c   145                                                      
REMARK 465     TYR c   146                                                      
REMARK 465     HIS c   147                                                      
REMARK 465     THR c   148                                                      
REMARK 465     GLN c   149                                                      
REMARK 465     GLY c   150                                                      
REMARK 465     TYR c   151                                                      
REMARK 465     PHE c   152                                                      
REMARK 465     PRO c   153                                                      
REMARK 465     ASP c   154                                                      
REMARK 465     TRP c   155                                                      
REMARK 465     GLN c   156                                                      
REMARK 465     ASN c   157                                                      
REMARK 465     TYR c   158                                                      
REMARK 465     THR c   159                                                      
REMARK 465     PRO c   160                                                      
REMARK 465     GLY c   161                                                      
REMARK 465     PRO c   162                                                      
REMARK 465     GLY c   163                                                      
REMARK 465     VAL c   164                                                      
REMARK 465     ARG c   165                                                      
REMARK 465     TYR c   166                                                      
REMARK 465     PRO c   167                                                      
REMARK 465     LEU c   168                                                      
REMARK 465     THR c   169                                                      
REMARK 465     PHE c   170                                                      
REMARK 465     GLY c   171                                                      
REMARK 465     TRP c   172                                                      
REMARK 465     CYS c   173                                                      
REMARK 465     TYR c   174                                                      
REMARK 465     LYS c   175                                                      
REMARK 465     LEU c   176                                                      
REMARK 465     VAL c   177                                                      
REMARK 465     PRO c   178                                                      
REMARK 465     VAL c   179                                                      
REMARK 465     GLU c   180                                                      
REMARK 465     PRO c   181                                                      
REMARK 465     ASP c   182                                                      
REMARK 465     LYS c   183                                                      
REMARK 465     VAL c   184                                                      
REMARK 465     GLU c   185                                                      
REMARK 465     GLU c   186                                                      
REMARK 465     ALA c   187                                                      
REMARK 465     ASN c   188                                                      
REMARK 465     LYS c   189                                                      
REMARK 465     GLY c   190                                                      
REMARK 465     GLU c   191                                                      
REMARK 465     ASN c   192                                                      
REMARK 465     THR c   193                                                      
REMARK 465     SER c   194                                                      
REMARK 465     LEU c   195                                                      
REMARK 465     LEU c   196                                                      
REMARK 465     HIS c   197                                                      
REMARK 465     PRO c   198                                                      
REMARK 465     VAL c   199                                                      
REMARK 465     SER c   200                                                      
REMARK 465     LEU c   201                                                      
REMARK 465     HIS c   202                                                      
REMARK 465     GLY c   203                                                      
REMARK 465     MET c   204                                                      
REMARK 465     ASP c   205                                                      
REMARK 465     ASP c   206                                                      
REMARK 465     PRO c   207                                                      
REMARK 465     GLU c   208                                                      
REMARK 465     ARG c   209                                                      
REMARK 465     GLU c   210                                                      
REMARK 465     VAL c   211                                                      
REMARK 465     LEU c   212                                                      
REMARK 465     GLU c   213                                                      
REMARK 465     TRP c   214                                                      
REMARK 465     ARG c   215                                                      
REMARK 465     PHE c   216                                                      
REMARK 465     ASP c   217                                                      
REMARK 465     SER c   218                                                      
REMARK 465     ARG c   219                                                      
REMARK 465     LEU c   220                                                      
REMARK 465     ALA c   221                                                      
REMARK 465     PHE c   222                                                      
REMARK 465     HIS c   223                                                      
REMARK 465     HIS c   224                                                      
REMARK 465     VAL c   225                                                      
REMARK 465     ALA c   226                                                      
REMARK 465     ARG c   227                                                      
REMARK 465     GLU c   228                                                      
REMARK 465     LEU c   229                                                      
REMARK 465     HIS c   230                                                      
REMARK 465     PRO c   231                                                      
REMARK 465     GLU c   232                                                      
REMARK 465     TYR c   233                                                      
REMARK 465     PHE c   234                                                      
REMARK 465     LYS c   235                                                      
REMARK 465     ASN c   236                                                      
REMARK 465     CYS c   237                                                      
REMARK 465     GLN U   180                                                      
REMARK 465     LYS U   181                                                      
REMARK 465     GLY W   139                                                      
REMARK 465     HIS W   140                                                      
REMARK 465     LYS W   141                                                      
REMARK 465     LEU W   142                                                      
REMARK 465     GLU W   143                                                      
REMARK 465     THR W   144                                                      
REMARK 465     GLY W   145                                                      
REMARK 465     MET Y   -57                                                      
REMARK 465     SER Y   -56                                                      
REMARK 465     TYR Y   -55                                                      
REMARK 465     TYR Y   -54                                                      
REMARK 465     HIS Y   -53                                                      
REMARK 465     HIS Y   -52                                                      
REMARK 465     HIS Y   -51                                                      
REMARK 465     HIS Y   -50                                                      
REMARK 465     HIS Y   -49                                                      
REMARK 465     HIS Y   -48                                                      
REMARK 465     ASP Y   -47                                                      
REMARK 465     TYR Y   -46                                                      
REMARK 465     ASP Y   -45                                                      
REMARK 465     ILE Y   -44                                                      
REMARK 465     PRO Y   -43                                                      
REMARK 465     THR Y   -42                                                      
REMARK 465     THR Y   -41                                                      
REMARK 465     GLU Y   -40                                                      
REMARK 465     ASN Y   -39                                                      
REMARK 465     LEU Y   -38                                                      
REMARK 465     TYR Y   -37                                                      
REMARK 465     PHE Y   -36                                                      
REMARK 465     GLN Y   -35                                                      
REMARK 465     GLY Y   -34                                                      
REMARK 465     ALA Y   -33                                                      
REMARK 465     MET Y   -32                                                      
REMARK 465     GLY Y   -31                                                      
REMARK 465     SER Y   -30                                                      
REMARK 465     ALA Y   -29                                                      
REMARK 465     SER Y   -28                                                      
REMARK 465     THR Y   -27                                                      
REMARK 465     SER Y   -26                                                      
REMARK 465     TYR Y   -25                                                      
REMARK 465     ASP Y   -24                                                      
REMARK 465     TYR Y   -23                                                      
REMARK 465     CYS Y   -22                                                      
REMARK 465     ARG Y   -21                                                      
REMARK 465     VAL Y   -20                                                      
REMARK 465     PRO Y   -19                                                      
REMARK 465     MET Y   -18                                                      
REMARK 465     GLU Y   -17                                                      
REMARK 465     ASP Y   -16                                                      
REMARK 465     GLY Y   -15                                                      
REMARK 465     ASP Y   -14                                                      
REMARK 465     LYS Y   -13                                                      
REMARK 465     ARG Y   -12                                                      
REMARK 465     CYS Y   -11                                                      
REMARK 465     LYS Y   -10                                                      
REMARK 465     GLY Y    -9                                                      
REMARK 465     SER Y    -8                                                      
REMARK 465     ASP Y    -7                                                      
REMARK 465     GLU Y    -6                                                      
REMARK 465     ALA Y    -5                                                      
REMARK 465     SER Y    -4                                                      
REMARK 465     GLU Y    -3                                                      
REMARK 465     GLY Y    -2                                                      
REMARK 465     SER Y    -1                                                      
REMARK 465     GLY Y     0                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     GLY Y     2                                                      
REMARK 465     GLY Y     3                                                      
REMARK 465     LYS Y     4                                                      
REMARK 465     TRP Y     5                                                      
REMARK 465     ALA Y    27                                                      
REMARK 465     ASP Y    28                                                      
REMARK 465     GLY Y    29                                                      
REMARK 465     VAL Y    30                                                      
REMARK 465     GLY Y    31                                                      
REMARK 465     ALA Y    32                                                      
REMARK 465     VAL Y    33                                                      
REMARK 465     SER Y    34                                                      
REMARK 465     ARG Y    35                                                      
REMARK 465     ASP Y    36                                                      
REMARK 465     LEU Y    37                                                      
REMARK 465     GLU Y    38                                                      
REMARK 465     LYS Y    39                                                      
REMARK 465     HIS Y    40                                                      
REMARK 465     GLY Y    41                                                      
REMARK 465     ALA Y    42                                                      
REMARK 465     ILE Y    43                                                      
REMARK 465     THR Y    44                                                      
REMARK 465     SER Y    45                                                      
REMARK 465     SER Y    46                                                      
REMARK 465     ASN Y    47                                                      
REMARK 465     THR Y    48                                                      
REMARK 465     ALA Y    49                                                      
REMARK 465     ALA Y    50                                                      
REMARK 465     ASN Y    51                                                      
REMARK 465     ASN Y    52                                                      
REMARK 465     ALA Y    53                                                      
REMARK 465     ALA Y    54                                                      
REMARK 465     CYS Y    55                                                      
REMARK 465     ALA Y    56                                                      
REMARK 465     TRP Y    57                                                      
REMARK 465     LEU Y    58                                                      
REMARK 465     GLU Y    59                                                      
REMARK 465     ALA Y    60                                                      
REMARK 465     GLN Y    61                                                      
REMARK 465     GLU Y    62                                                      
REMARK 465     GLU Y    63                                                      
REMARK 465     GLU Y   149                                                      
REMARK 465     PRO Y   150                                                      
REMARK 465     ASP Y   151                                                      
REMARK 465     LYS Y   152                                                      
REMARK 465     VAL Y   153                                                      
REMARK 465     GLU Y   154                                                      
REMARK 465     GLU Y   155                                                      
REMARK 465     ALA Y   156                                                      
REMARK 465     ASN Y   157                                                      
REMARK 465     VAL Y   168                                                      
REMARK 465     SER Y   169                                                      
REMARK 465     LEU Y   170                                                      
REMARK 465     HIS Y   171                                                      
REMARK 465     GLY Y   172                                                      
REMARK 465     MET Y   173                                                      
REMARK 465     ASP Y   174                                                      
REMARK 465     ASP Y   175                                                      
REMARK 465     PRO Y   176                                                      
REMARK 465     GLU Y   177                                                      
REMARK 465     ARG Y   178                                                      
REMARK 465     GLU Y   179                                                      
REMARK 465     ASN Y   205                                                      
REMARK 465     CYS Y   206                                                      
REMARK 465     MET d   -26                                                      
REMARK 465     SER d   -25                                                      
REMARK 465     TYR d   -24                                                      
REMARK 465     TYR d   -23                                                      
REMARK 465     HIS d   -22                                                      
REMARK 465     HIS d   -21                                                      
REMARK 465     HIS d   -20                                                      
REMARK 465     HIS d   -19                                                      
REMARK 465     HIS d   -18                                                      
REMARK 465     HIS d   -17                                                      
REMARK 465     ASP d   -16                                                      
REMARK 465     TYR d   -15                                                      
REMARK 465     ASP d   -14                                                      
REMARK 465     ILE d   -13                                                      
REMARK 465     PRO d   -12                                                      
REMARK 465     THR d   -11                                                      
REMARK 465     THR d   -10                                                      
REMARK 465     GLU d    -9                                                      
REMARK 465     ASN d    -8                                                      
REMARK 465     LEU d    -7                                                      
REMARK 465     TYR d    -6                                                      
REMARK 465     PHE d    -5                                                      
REMARK 465     GLN d    -4                                                      
REMARK 465     GLY d    -3                                                      
REMARK 465     ALA d    -2                                                      
REMARK 465     MET d    -1                                                      
REMARK 465     GLY d     0                                                      
REMARK 465     SER d     1                                                      
REMARK 465     ALA d     2                                                      
REMARK 465     SER d     3                                                      
REMARK 465     ASP d    17                                                      
REMARK 465     LYS d    18                                                      
REMARK 465     ARG d    19                                                      
REMARK 465     CYS d    20                                                      
REMARK 465     LYS d    21                                                      
REMARK 465     GLY d    22                                                      
REMARK 465     SER d    23                                                      
REMARK 465     ASP d    24                                                      
REMARK 465     GLU d    25                                                      
REMARK 465     ALA d    26                                                      
REMARK 465     SER d    27                                                      
REMARK 465     GLU d    28                                                      
REMARK 465     GLY d    29                                                      
REMARK 465     SER d    30                                                      
REMARK 465     GLY d    31                                                      
REMARK 465     MET d    32                                                      
REMARK 465     GLY d    33                                                      
REMARK 465     GLY d    34                                                      
REMARK 465     LYS d    35                                                      
REMARK 465     TRP d    36                                                      
REMARK 465     SER d    37                                                      
REMARK 465     LYS d    38                                                      
REMARK 465     SER d    39                                                      
REMARK 465     SER d    40                                                      
REMARK 465     VAL d    41                                                      
REMARK 465     ILE d    42                                                      
REMARK 465     GLY d    43                                                      
REMARK 465     TRP d    44                                                      
REMARK 465     PRO d    45                                                      
REMARK 465     ALA d    46                                                      
REMARK 465     VAL d    47                                                      
REMARK 465     ARG d    48                                                      
REMARK 465     GLU d    49                                                      
REMARK 465     ARG d    50                                                      
REMARK 465     MET d    51                                                      
REMARK 465     ARG d    52                                                      
REMARK 465     ARG d    53                                                      
REMARK 465     ALA d    54                                                      
REMARK 465     GLU d    55                                                      
REMARK 465     PRO d    56                                                      
REMARK 465     ALA d    57                                                      
REMARK 465     ALA d    58                                                      
REMARK 465     ASP d    59                                                      
REMARK 465     GLY d    60                                                      
REMARK 465     VAL d    61                                                      
REMARK 465     GLY d    62                                                      
REMARK 465     ALA d    63                                                      
REMARK 465     VAL d    64                                                      
REMARK 465     SER d    65                                                      
REMARK 465     ARG d    66                                                      
REMARK 465     ASP d    67                                                      
REMARK 465     LEU d    68                                                      
REMARK 465     GLU d    69                                                      
REMARK 465     LYS d    70                                                      
REMARK 465     HIS d    71                                                      
REMARK 465     GLY d    72                                                      
REMARK 465     ALA d    73                                                      
REMARK 465     ILE d    74                                                      
REMARK 465     THR d    75                                                      
REMARK 465     SER d    76                                                      
REMARK 465     SER d    77                                                      
REMARK 465     ASN d    78                                                      
REMARK 465     THR d    79                                                      
REMARK 465     ALA d    80                                                      
REMARK 465     ALA d    81                                                      
REMARK 465     ASN d    82                                                      
REMARK 465     ASN d    83                                                      
REMARK 465     ALA d    84                                                      
REMARK 465     ALA d    85                                                      
REMARK 465     CYS d    86                                                      
REMARK 465     ALA d    87                                                      
REMARK 465     TRP d    88                                                      
REMARK 465     LEU d    89                                                      
REMARK 465     GLU d    90                                                      
REMARK 465     ALA d    91                                                      
REMARK 465     GLN d    92                                                      
REMARK 465     GLU d    93                                                      
REMARK 465     GLU d    94                                                      
REMARK 465     GLU d    95                                                      
REMARK 465     GLU d    96                                                      
REMARK 465     VAL d    97                                                      
REMARK 465     GLY d    98                                                      
REMARK 465     PHE d    99                                                      
REMARK 465     PRO d   100                                                      
REMARK 465     VAL d   101                                                      
REMARK 465     THR d   102                                                      
REMARK 465     PRO d   103                                                      
REMARK 465     GLN d   104                                                      
REMARK 465     VAL d   105                                                      
REMARK 465     PRO d   106                                                      
REMARK 465     LEU d   107                                                      
REMARK 465     ARG d   108                                                      
REMARK 465     PRO d   109                                                      
REMARK 465     MET d   110                                                      
REMARK 465     THR d   111                                                      
REMARK 465     TYR d   112                                                      
REMARK 465     LYS d   113                                                      
REMARK 465     ALA d   114                                                      
REMARK 465     ALA d   115                                                      
REMARK 465     VAL d   116                                                      
REMARK 465     ASP d   117                                                      
REMARK 465     LEU d   118                                                      
REMARK 465     SER d   119                                                      
REMARK 465     HIS d   120                                                      
REMARK 465     PHE d   121                                                      
REMARK 465     LEU d   122                                                      
REMARK 465     LYS d   123                                                      
REMARK 465     GLU d   124                                                      
REMARK 465     LYS d   125                                                      
REMARK 465     GLY d   126                                                      
REMARK 465     GLY d   127                                                      
REMARK 465     LEU d   128                                                      
REMARK 465     GLU d   129                                                      
REMARK 465     GLY d   130                                                      
REMARK 465     LEU d   131                                                      
REMARK 465     ILE d   132                                                      
REMARK 465     HIS d   133                                                      
REMARK 465     SER d   134                                                      
REMARK 465     GLN d   135                                                      
REMARK 465     ARG d   136                                                      
REMARK 465     ARG d   137                                                      
REMARK 465     GLN d   138                                                      
REMARK 465     ASP d   139                                                      
REMARK 465     ILE d   140                                                      
REMARK 465     LEU d   141                                                      
REMARK 465     ASP d   142                                                      
REMARK 465     LEU d   143                                                      
REMARK 465     TRP d   144                                                      
REMARK 465     ILE d   145                                                      
REMARK 465     TYR d   146                                                      
REMARK 465     HIS d   147                                                      
REMARK 465     THR d   148                                                      
REMARK 465     GLN d   149                                                      
REMARK 465     GLY d   150                                                      
REMARK 465     TYR d   151                                                      
REMARK 465     PHE d   152                                                      
REMARK 465     PRO d   153                                                      
REMARK 465     ASP d   154                                                      
REMARK 465     TRP d   155                                                      
REMARK 465     GLN d   156                                                      
REMARK 465     ASN d   157                                                      
REMARK 465     TYR d   158                                                      
REMARK 465     THR d   159                                                      
REMARK 465     PRO d   160                                                      
REMARK 465     GLY d   161                                                      
REMARK 465     PRO d   162                                                      
REMARK 465     GLY d   163                                                      
REMARK 465     VAL d   164                                                      
REMARK 465     ARG d   165                                                      
REMARK 465     TYR d   166                                                      
REMARK 465     PRO d   167                                                      
REMARK 465     LEU d   168                                                      
REMARK 465     THR d   169                                                      
REMARK 465     PHE d   170                                                      
REMARK 465     GLY d   171                                                      
REMARK 465     TRP d   172                                                      
REMARK 465     CYS d   173                                                      
REMARK 465     TYR d   174                                                      
REMARK 465     LYS d   175                                                      
REMARK 465     LEU d   176                                                      
REMARK 465     VAL d   177                                                      
REMARK 465     PRO d   178                                                      
REMARK 465     VAL d   179                                                      
REMARK 465     GLU d   180                                                      
REMARK 465     PRO d   181                                                      
REMARK 465     ASP d   182                                                      
REMARK 465     LYS d   183                                                      
REMARK 465     VAL d   184                                                      
REMARK 465     GLU d   185                                                      
REMARK 465     GLU d   186                                                      
REMARK 465     ALA d   187                                                      
REMARK 465     ASN d   188                                                      
REMARK 465     LYS d   189                                                      
REMARK 465     GLY d   190                                                      
REMARK 465     GLU d   191                                                      
REMARK 465     ASN d   192                                                      
REMARK 465     THR d   193                                                      
REMARK 465     SER d   194                                                      
REMARK 465     LEU d   195                                                      
REMARK 465     LEU d   196                                                      
REMARK 465     HIS d   197                                                      
REMARK 465     PRO d   198                                                      
REMARK 465     VAL d   199                                                      
REMARK 465     SER d   200                                                      
REMARK 465     LEU d   201                                                      
REMARK 465     HIS d   202                                                      
REMARK 465     GLY d   203                                                      
REMARK 465     MET d   204                                                      
REMARK 465     ASP d   205                                                      
REMARK 465     ASP d   206                                                      
REMARK 465     PRO d   207                                                      
REMARK 465     GLU d   208                                                      
REMARK 465     ARG d   209                                                      
REMARK 465     GLU d   210                                                      
REMARK 465     VAL d   211                                                      
REMARK 465     LEU d   212                                                      
REMARK 465     GLU d   213                                                      
REMARK 465     TRP d   214                                                      
REMARK 465     ARG d   215                                                      
REMARK 465     PHE d   216                                                      
REMARK 465     ASP d   217                                                      
REMARK 465     SER d   218                                                      
REMARK 465     ARG d   219                                                      
REMARK 465     LEU d   220                                                      
REMARK 465     ALA d   221                                                      
REMARK 465     PHE d   222                                                      
REMARK 465     HIS d   223                                                      
REMARK 465     HIS d   224                                                      
REMARK 465     VAL d   225                                                      
REMARK 465     ALA d   226                                                      
REMARK 465     ARG d   227                                                      
REMARK 465     GLU d   228                                                      
REMARK 465     LEU d   229                                                      
REMARK 465     HIS d   230                                                      
REMARK 465     PRO d   231                                                      
REMARK 465     GLU d   232                                                      
REMARK 465     TYR d   233                                                      
REMARK 465     PHE d   234                                                      
REMARK 465     LYS d   235                                                      
REMARK 465     ASN d   236                                                      
REMARK 465     CYS d   237                                                      
REMARK 465     GLN V   180                                                      
REMARK 465     LYS V   181                                                      
REMARK 465     GLY X   139                                                      
REMARK 465     HIS X   140                                                      
REMARK 465     LYS X   141                                                      
REMARK 465     LEU X   142                                                      
REMARK 465     GLU X   143                                                      
REMARK 465     THR X   144                                                      
REMARK 465     GLY X   145                                                      
REMARK 465     MET Z   -57                                                      
REMARK 465     SER Z   -56                                                      
REMARK 465     TYR Z   -55                                                      
REMARK 465     TYR Z   -54                                                      
REMARK 465     HIS Z   -53                                                      
REMARK 465     HIS Z   -52                                                      
REMARK 465     HIS Z   -51                                                      
REMARK 465     HIS Z   -50                                                      
REMARK 465     HIS Z   -49                                                      
REMARK 465     HIS Z   -48                                                      
REMARK 465     ASP Z   -47                                                      
REMARK 465     TYR Z   -46                                                      
REMARK 465     ASP Z   -45                                                      
REMARK 465     ILE Z   -44                                                      
REMARK 465     PRO Z   -43                                                      
REMARK 465     THR Z   -42                                                      
REMARK 465     THR Z   -41                                                      
REMARK 465     GLU Z   -40                                                      
REMARK 465     ASN Z   -39                                                      
REMARK 465     LEU Z   -38                                                      
REMARK 465     TYR Z   -37                                                      
REMARK 465     PHE Z   -36                                                      
REMARK 465     GLN Z   -35                                                      
REMARK 465     GLY Z   -34                                                      
REMARK 465     ALA Z   -33                                                      
REMARK 465     MET Z   -32                                                      
REMARK 465     GLY Z   -31                                                      
REMARK 465     SER Z   -30                                                      
REMARK 465     ALA Z   -29                                                      
REMARK 465     SER Z   -28                                                      
REMARK 465     THR Z   -27                                                      
REMARK 465     SER Z   -26                                                      
REMARK 465     TYR Z   -25                                                      
REMARK 465     ASP Z   -24                                                      
REMARK 465     TYR Z   -23                                                      
REMARK 465     CYS Z   -22                                                      
REMARK 465     ARG Z   -21                                                      
REMARK 465     VAL Z   -20                                                      
REMARK 465     PRO Z   -19                                                      
REMARK 465     MET Z   -18                                                      
REMARK 465     GLU Z   -17                                                      
REMARK 465     ASP Z   -16                                                      
REMARK 465     GLY Z   -15                                                      
REMARK 465     ASP Z   -14                                                      
REMARK 465     LYS Z   -13                                                      
REMARK 465     ARG Z   -12                                                      
REMARK 465     CYS Z   -11                                                      
REMARK 465     LYS Z   -10                                                      
REMARK 465     GLY Z    -9                                                      
REMARK 465     SER Z    -8                                                      
REMARK 465     ASP Z    -7                                                      
REMARK 465     GLU Z    -6                                                      
REMARK 465     ALA Z    -5                                                      
REMARK 465     SER Z    -4                                                      
REMARK 465     GLU Z    -3                                                      
REMARK 465     GLY Z    -2                                                      
REMARK 465     SER Z    -1                                                      
REMARK 465     GLY Z     0                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     GLY Z     2                                                      
REMARK 465     GLY Z     3                                                      
REMARK 465     LYS Z     4                                                      
REMARK 465     TRP Z     5                                                      
REMARK 465     ALA Z    27                                                      
REMARK 465     ASP Z    28                                                      
REMARK 465     GLY Z    29                                                      
REMARK 465     VAL Z    30                                                      
REMARK 465     GLY Z    31                                                      
REMARK 465     ALA Z    32                                                      
REMARK 465     VAL Z    33                                                      
REMARK 465     SER Z    34                                                      
REMARK 465     ARG Z    35                                                      
REMARK 465     ASP Z    36                                                      
REMARK 465     LEU Z    37                                                      
REMARK 465     GLU Z    38                                                      
REMARK 465     LYS Z    39                                                      
REMARK 465     HIS Z    40                                                      
REMARK 465     GLY Z    41                                                      
REMARK 465     ALA Z    42                                                      
REMARK 465     ILE Z    43                                                      
REMARK 465     THR Z    44                                                      
REMARK 465     SER Z    45                                                      
REMARK 465     SER Z    46                                                      
REMARK 465     ASN Z    47                                                      
REMARK 465     THR Z    48                                                      
REMARK 465     ALA Z    49                                                      
REMARK 465     ALA Z    50                                                      
REMARK 465     ASN Z    51                                                      
REMARK 465     ASN Z    52                                                      
REMARK 465     ALA Z    53                                                      
REMARK 465     ALA Z    54                                                      
REMARK 465     CYS Z    55                                                      
REMARK 465     ALA Z    56                                                      
REMARK 465     TRP Z    57                                                      
REMARK 465     LEU Z    58                                                      
REMARK 465     GLU Z    59                                                      
REMARK 465     ALA Z    60                                                      
REMARK 465     GLN Z    61                                                      
REMARK 465     GLU Z    62                                                      
REMARK 465     GLU Z    63                                                      
REMARK 465     GLU Z   149                                                      
REMARK 465     PRO Z   150                                                      
REMARK 465     ASP Z   151                                                      
REMARK 465     LYS Z   152                                                      
REMARK 465     VAL Z   153                                                      
REMARK 465     GLU Z   154                                                      
REMARK 465     GLU Z   155                                                      
REMARK 465     ALA Z   156                                                      
REMARK 465     ASN Z   157                                                      
REMARK 465     VAL Z   168                                                      
REMARK 465     SER Z   169                                                      
REMARK 465     LEU Z   170                                                      
REMARK 465     HIS Z   171                                                      
REMARK 465     GLY Z   172                                                      
REMARK 465     MET Z   173                                                      
REMARK 465     ASP Z   174                                                      
REMARK 465     ASP Z   175                                                      
REMARK 465     PRO Z   176                                                      
REMARK 465     GLU Z   177                                                      
REMARK 465     ARG Z   178                                                      
REMARK 465     GLU Z   179                                                      
REMARK 465     ASN Z   205                                                      
REMARK 465     CYS Z   206                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU N  64    CG   CD   OE1  OE2                                  
REMARK 470     GLU Y  64    CG   CD   OE1  OE2                                  
REMARK 470     GLU Z  64    CG   CD   OE1  OE2                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    PHE M   385     OG1  THR M   413              2.19            
REMARK 500   O    PHE X   385     OG1  THR X   413              2.19            
REMARK 500   O    PHE W   385     OG1  THR W   413              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU B  50       33.36    -94.26                                   
REMARK 500    CYS B  57       59.22    -96.10                                   
REMARK 500    MET B  86       34.10    -90.68                                   
REMARK 500    LYS B 131       40.23   -103.97                                   
REMARK 500    ASN B 173       81.64     53.60                                   
REMARK 500    ALA B 294     -168.04   -100.83                                   
REMARK 500    ASN B 350       40.13   -140.75                                   
REMARK 500    LEU B 436       71.43     59.17                                   
REMARK 500    ASP B 437       -4.32    -59.82                                   
REMARK 500    ALA B 456       46.83    -86.79                                   
REMARK 500    GLU B 457      -34.22   -132.36                                   
REMARK 500    ASP B 475       34.56   -142.56                                   
REMARK 500    LEU B 542       48.74    -95.43                                   
REMARK 500    ARG G  18      -64.99    -96.50                                   
REMARK 500    LEU G  91      -60.70    -99.15                                   
REMARK 500    ASP G  98      -11.02     73.37                                   
REMARK 500    HIS G 235       -5.85     66.64                                   
REMARK 500    GLN G 469       98.27    -69.61                                   
REMARK 500    GLU G 495     -166.98   -125.25                                   
REMARK 500    GLU G 502       15.55     51.22                                   
REMARK 500    ASP G 503      -44.72   -131.55                                   
REMARK 500    SER G 520      -11.59     68.34                                   
REMARK 500    LEU G 581       34.56    -98.40                                   
REMARK 500    ASN H  60       39.51     37.39                                   
REMARK 500    MET M  45       37.21    -95.38                                   
REMARK 500    PHE M 120       -2.09     67.14                                   
REMARK 500    ASP M 250       34.78   -145.89                                   
REMARK 500    ASN M 309       49.96     35.43                                   
REMARK 500    SER M 322       74.37     50.33                                   
REMARK 500    SER S  41       35.25    -95.05                                   
REMARK 500    SER S  48       16.42     58.08                                   
REMARK 500    ALA S  63     -158.55   -147.40                                   
REMARK 500    PRO N 122       47.89    -80.77                                   
REMARK 500    GLN N 125       49.26    -91.30                                   
REMARK 500    LEU I  50       33.45    -94.23                                   
REMARK 500    CYS I  57       59.24    -96.05                                   
REMARK 500    MET I  86       34.09    -90.68                                   
REMARK 500    LYS I 131       40.17   -104.01                                   
REMARK 500    ASN I 173       81.67     53.55                                   
REMARK 500    ALA I 294     -168.06   -100.87                                   
REMARK 500    ASN I 350       40.15   -140.74                                   
REMARK 500    LEU I 436       71.39     59.23                                   
REMARK 500    ASP I 437       -4.29    -59.82                                   
REMARK 500    ALA I 456       46.81    -86.79                                   
REMARK 500    GLU I 457      -34.27   -132.35                                   
REMARK 500    ASP I 475       34.56   -142.58                                   
REMARK 500    LEU I 542       48.73    -95.45                                   
REMARK 500    ALA K 112       36.34    -98.07                                   
REMARK 500    GLN K 128       59.69    -93.72                                   
REMARK 500    ARG Q  18      -65.02    -96.46                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     107 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 VAL G  521     THR G  522                  149.16                    
REMARK 500 VAL Q  521     THR Q  522                  149.12                    
REMARK 500 VAL R  521     THR R  522                  149.14                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG C1002  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR C  31   OG1                                                    
REMARK 620 2 THR C  48   OG1 161.0                                              
REMARK 620 3 GTP C1001   O1G 124.6  64.0                                        
REMARK 620 4 GTP C1001   O3G 143.4  53.0  70.2                                  
REMARK 620 5 GTP C1001   O2B  66.7 131.0 101.2  78.0                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG H1002  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR H  31   OG1                                                    
REMARK 620 2 THR H  48   OG1 152.4                                              
REMARK 620 3 GTP H1001   O1G 145.0  60.2                                        
REMARK 620 4 GTP H1001   O2G 119.5  73.7  70.2                                  
REMARK 620 5 GTP H1001   O1B  67.2 137.3  78.0 101.2                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG K1002  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR K  31   OG1                                                    
REMARK 620 2 THR K  48   OG1 162.5                                              
REMARK 620 3 GTP K1001   O1G 125.2  63.9                                        
REMARK 620 4 GTP K1001   O3G 142.6  51.8  70.2                                  
REMARK 620 5 GTP K1001   O2B  66.0 129.8 101.2  78.0                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG U1002  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR U  31   OG1                                                    
REMARK 620 2 THR U  48   OG1 152.9                                              
REMARK 620 3 GTP U1001   O1G 143.4  60.5                                        
REMARK 620 4 GTP U1001   O2G 120.4  74.4  70.1                                  
REMARK 620 5 GTP U1001   O1B  65.8 137.5  78.0 101.2                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG L1002  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR L  31   OG1                                                    
REMARK 620 2 THR L  48   OG1 162.3                                              
REMARK 620 3 GTP L1001   O1G 123.4  62.3                                        
REMARK 620 4 GTP L1001   O3G 143.1  53.4  70.2                                  
REMARK 620 5 GTP L1001   O2B  66.0 131.3 101.2  78.0                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG V1002  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR V  31   OG1                                                    
REMARK 620 2 THR V  48   OG1 153.3                                              
REMARK 620 3 GTP V1001   O1G 141.9  60.7                                        
REMARK 620 4 GTP V1001   O2G 122.0  73.9  70.2                                  
REMARK 620 5 GTP V1001   O1B  64.6 137.8  78.0 101.2                            
REMARK 620 N                    1     2     3     4                             
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GTP C 1001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG C 1002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GTP H 1001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG H 1002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GTP K 1001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG K 1002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GTP U 1001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG U 1002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GTP L 1001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG L 1002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GTP V 1001                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG V 1002                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-7563   RELATED DB: EMDB                              
REMARK 900 STRUCTURE OF THE HIV-NEF TETHERIN CARGO BOUND AP-1:ARF1 STABLE       
REMARK 900 CLOSED TRIMER                                                        
REMARK 900 RELATED ID: 6CRI   RELATED DB: PDB                                   
REMARK 900 RELATED ID: EMD-7458   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-7457   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-7456   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-7455   RELATED DB: EMDB                              
DBREF  6CRI T    2    21  UNP    Q10589   BST2_HUMAN       2     21             
DBREF  6CRI T   32   237  UNP    Q90VU7   Q90VU7_9HIV1     1    206             
DBREF  6CRI B   14   583  UNP    Q10567   AP1B1_HUMAN     14    583             
DBREF  6CRI C   17   181  UNP    P84077   ARF1_HUMAN      17    181             
DBREF  6CRI G    4   588  UNP    P22892   AP1G1_MOUSE      4    588             
DBREF  6CRI H   17   181  UNP    P84077   ARF1_HUMAN      17    181             
DBREF  6CRI M    2   423  UNP    P35585   AP1M1_MOUSE      2    423             
DBREF  6CRI S    1   142  UNP    Q96PC3   AP1S3_HUMAN      1    142             
DBREF  6CRI N  -29   -10  UNP    Q10589   BST2_HUMAN       2     21             
DBREF  6CRI N    1   206  UNP    Q90VU7   Q90VU7_9HIV1     1    206             
DBREF  6CRI c    2    21  UNP    Q10589   BST2_HUMAN       2     21             
DBREF  6CRI c   32   237  UNP    Q90VU7   Q90VU7_9HIV1     1    206             
DBREF  6CRI I   14   583  UNP    Q10567   AP1B1_HUMAN     14    583             
DBREF  6CRI K   17   181  UNP    P84077   ARF1_HUMAN      17    181             
DBREF  6CRI Q    4   588  UNP    P22892   AP1G1_MOUSE      4    588             
DBREF  6CRI U   17   181  UNP    P84077   ARF1_HUMAN      17    181             
DBREF  6CRI W    2   423  UNP    P35585   AP1M1_MOUSE      2    423             
DBREF  6CRI a    1   142  UNP    Q96PC3   AP1S3_HUMAN      1    142             
DBREF  6CRI Y  -29   -10  UNP    Q10589   BST2_HUMAN       2     21             
DBREF  6CRI Y    1   206  UNP    Q90VU7   Q90VU7_9HIV1     1    206             
DBREF  6CRI d    2    21  UNP    Q10589   BST2_HUMAN       2     21             
DBREF  6CRI d   32   237  UNP    Q90VU7   Q90VU7_9HIV1     1    206             
DBREF  6CRI J   14   583  UNP    Q10567   AP1B1_HUMAN     14    583             
DBREF  6CRI L   17   181  UNP    P84077   ARF1_HUMAN      17    181             
DBREF  6CRI R    4   588  UNP    P22892   AP1G1_MOUSE      4    588             
DBREF  6CRI V   17   181  UNP    P84077   ARF1_HUMAN      17    181             
DBREF  6CRI X    2   423  UNP    P35585   AP1M1_MOUSE      2    423             
DBREF  6CRI b    1   142  UNP    Q96PC3   AP1S3_HUMAN      1    142             
DBREF  6CRI Z  -29   -10  UNP    Q10589   BST2_HUMAN       2     21             
DBREF  6CRI Z    1   206  UNP    Q90VU7   Q90VU7_9HIV1     1    206             
SEQADV 6CRI MET T  -26  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER T  -25  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR T  -24  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR T  -23  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS T  -22  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS T  -21  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS T  -20  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS T  -19  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS T  -18  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS T  -17  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP T  -16  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR T  -15  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP T  -14  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ILE T  -13  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PRO T  -12  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR T  -11  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR T  -10  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLU T   -9  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASN T   -8  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI LEU T   -7  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR T   -6  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PHE T   -5  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLN T   -4  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY T   -3  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ALA T   -2  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI MET T   -1  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY T    0  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER T    1  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY T   22  UNP  Q10589              LINKER                         
SEQADV 6CRI SER T   23  UNP  Q10589              LINKER                         
SEQADV 6CRI ASP T   24  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU T   25  UNP  Q10589              LINKER                         
SEQADV 6CRI ALA T   26  UNP  Q10589              LINKER                         
SEQADV 6CRI SER T   27  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU T   28  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY T   29  UNP  Q10589              LINKER                         
SEQADV 6CRI SER T   30  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY T   31  UNP  Q10589              LINKER                         
SEQADV 6CRI ARG B  359  UNP  Q10567    LYS   359 ENGINEERED MUTATION            
SEQADV 6CRI LYS B  476  UNP  Q10567    GLU   476 ENGINEERED MUTATION            
SEQADV 6CRI LEU C   71  UNP  P84077    GLN    71 ENGINEERED MUTATION            
SEQADV 6CRI LEU H   71  UNP  P84077    GLN    71 ENGINEERED MUTATION            
SEQADV 6CRI MET N  -57  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER N  -56  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR N  -55  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR N  -54  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS N  -53  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS N  -52  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS N  -51  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS N  -50  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS N  -49  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS N  -48  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP N  -47  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR N  -46  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP N  -45  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ILE N  -44  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PRO N  -43  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR N  -42  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR N  -41  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLU N  -40  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASN N  -39  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI LEU N  -38  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR N  -37  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PHE N  -36  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLN N  -35  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY N  -34  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ALA N  -33  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI MET N  -32  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY N  -31  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER N  -30  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY N   -9  UNP  Q10589              LINKER                         
SEQADV 6CRI SER N   -8  UNP  Q10589              LINKER                         
SEQADV 6CRI ASP N   -7  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU N   -6  UNP  Q10589              LINKER                         
SEQADV 6CRI ALA N   -5  UNP  Q10589              LINKER                         
SEQADV 6CRI SER N   -4  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU N   -3  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY N   -2  UNP  Q10589              LINKER                         
SEQADV 6CRI SER N   -1  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY N    0  UNP  Q10589              LINKER                         
SEQADV 6CRI MET c  -26  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER c  -25  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR c  -24  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR c  -23  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS c  -22  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS c  -21  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS c  -20  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS c  -19  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS c  -18  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS c  -17  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP c  -16  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR c  -15  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP c  -14  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ILE c  -13  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PRO c  -12  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR c  -11  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR c  -10  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLU c   -9  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASN c   -8  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI LEU c   -7  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR c   -6  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PHE c   -5  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLN c   -4  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY c   -3  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ALA c   -2  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI MET c   -1  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY c    0  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER c    1  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY c   22  UNP  Q10589              LINKER                         
SEQADV 6CRI SER c   23  UNP  Q10589              LINKER                         
SEQADV 6CRI ASP c   24  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU c   25  UNP  Q10589              LINKER                         
SEQADV 6CRI ALA c   26  UNP  Q10589              LINKER                         
SEQADV 6CRI SER c   27  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU c   28  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY c   29  UNP  Q10589              LINKER                         
SEQADV 6CRI SER c   30  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY c   31  UNP  Q10589              LINKER                         
SEQADV 6CRI ARG I  359  UNP  Q10567    LYS   359 ENGINEERED MUTATION            
SEQADV 6CRI LYS I  476  UNP  Q10567    GLU   476 ENGINEERED MUTATION            
SEQADV 6CRI LEU K   71  UNP  P84077    GLN    71 ENGINEERED MUTATION            
SEQADV 6CRI LEU U   71  UNP  P84077    GLN    71 ENGINEERED MUTATION            
SEQADV 6CRI MET Y  -57  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER Y  -56  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR Y  -55  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR Y  -54  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Y  -53  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Y  -52  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Y  -51  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Y  -50  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Y  -49  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Y  -48  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP Y  -47  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR Y  -46  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP Y  -45  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ILE Y  -44  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PRO Y  -43  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR Y  -42  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR Y  -41  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLU Y  -40  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASN Y  -39  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI LEU Y  -38  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR Y  -37  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PHE Y  -36  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLN Y  -35  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY Y  -34  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ALA Y  -33  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI MET Y  -32  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY Y  -31  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER Y  -30  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY Y   -9  UNP  Q10589              LINKER                         
SEQADV 6CRI SER Y   -8  UNP  Q10589              LINKER                         
SEQADV 6CRI ASP Y   -7  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU Y   -6  UNP  Q10589              LINKER                         
SEQADV 6CRI ALA Y   -5  UNP  Q10589              LINKER                         
SEQADV 6CRI SER Y   -4  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU Y   -3  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY Y   -2  UNP  Q10589              LINKER                         
SEQADV 6CRI SER Y   -1  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY Y    0  UNP  Q10589              LINKER                         
SEQADV 6CRI MET d  -26  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER d  -25  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR d  -24  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR d  -23  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS d  -22  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS d  -21  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS d  -20  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS d  -19  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS d  -18  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS d  -17  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP d  -16  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR d  -15  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP d  -14  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ILE d  -13  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PRO d  -12  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR d  -11  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR d  -10  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLU d   -9  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASN d   -8  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI LEU d   -7  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR d   -6  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PHE d   -5  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLN d   -4  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY d   -3  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ALA d   -2  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI MET d   -1  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY d    0  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER d    1  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY d   22  UNP  Q10589              LINKER                         
SEQADV 6CRI SER d   23  UNP  Q10589              LINKER                         
SEQADV 6CRI ASP d   24  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU d   25  UNP  Q10589              LINKER                         
SEQADV 6CRI ALA d   26  UNP  Q10589              LINKER                         
SEQADV 6CRI SER d   27  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU d   28  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY d   29  UNP  Q10589              LINKER                         
SEQADV 6CRI SER d   30  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY d   31  UNP  Q10589              LINKER                         
SEQADV 6CRI ARG J  359  UNP  Q10567    LYS   359 ENGINEERED MUTATION            
SEQADV 6CRI LYS J  476  UNP  Q10567    GLU   476 ENGINEERED MUTATION            
SEQADV 6CRI LEU L   71  UNP  P84077    GLN    71 ENGINEERED MUTATION            
SEQADV 6CRI LEU V   71  UNP  P84077    GLN    71 ENGINEERED MUTATION            
SEQADV 6CRI MET Z  -57  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER Z  -56  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR Z  -55  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR Z  -54  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Z  -53  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Z  -52  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Z  -51  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Z  -50  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Z  -49  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI HIS Z  -48  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP Z  -47  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR Z  -46  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASP Z  -45  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ILE Z  -44  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PRO Z  -43  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR Z  -42  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI THR Z  -41  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLU Z  -40  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ASN Z  -39  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI LEU Z  -38  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI TYR Z  -37  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI PHE Z  -36  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLN Z  -35  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY Z  -34  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI ALA Z  -33  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI MET Z  -32  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY Z  -31  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI SER Z  -30  UNP  Q10589              EXPRESSION TAG                 
SEQADV 6CRI GLY Z   -9  UNP  Q10589              LINKER                         
SEQADV 6CRI SER Z   -8  UNP  Q10589              LINKER                         
SEQADV 6CRI ASP Z   -7  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU Z   -6  UNP  Q10589              LINKER                         
SEQADV 6CRI ALA Z   -5  UNP  Q10589              LINKER                         
SEQADV 6CRI SER Z   -4  UNP  Q10589              LINKER                         
SEQADV 6CRI GLU Z   -3  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY Z   -2  UNP  Q10589              LINKER                         
SEQADV 6CRI SER Z   -1  UNP  Q10589              LINKER                         
SEQADV 6CRI GLY Z    0  UNP  Q10589              LINKER                         
SEQRES   1 T  264  MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP          
SEQRES   2 T  264  ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET          
SEQRES   3 T  264  GLY SER ALA SER THR SER TYR ASP TYR CYS ARG VAL PRO          
SEQRES   4 T  264  MET GLU ASP GLY ASP LYS ARG CYS LYS GLY SER ASP GLU          
SEQRES   5 T  264  ALA SER GLU GLY SER GLY MET GLY GLY LYS TRP SER LYS          
SEQRES   6 T  264  SER SER VAL ILE GLY TRP PRO ALA VAL ARG GLU ARG MET          
SEQRES   7 T  264  ARG ARG ALA GLU PRO ALA ALA ASP GLY VAL GLY ALA VAL          
SEQRES   8 T  264  SER ARG ASP LEU GLU LYS HIS GLY ALA ILE THR SER SER          
SEQRES   9 T  264  ASN THR ALA ALA ASN ASN ALA ALA CYS ALA TRP LEU GLU          
SEQRES  10 T  264  ALA GLN GLU GLU GLU GLU VAL GLY PHE PRO VAL THR PRO          
SEQRES  11 T  264  GLN VAL PRO LEU ARG PRO MET THR TYR LYS ALA ALA VAL          
SEQRES  12 T  264  ASP LEU SER HIS PHE LEU LYS GLU LYS GLY GLY LEU GLU          
SEQRES  13 T  264  GLY LEU ILE HIS SER GLN ARG ARG GLN ASP ILE LEU ASP          
SEQRES  14 T  264  LEU TRP ILE TYR HIS THR GLN GLY TYR PHE PRO ASP TRP          
SEQRES  15 T  264  GLN ASN TYR THR PRO GLY PRO GLY VAL ARG TYR PRO LEU          
SEQRES  16 T  264  THR PHE GLY TRP CYS TYR LYS LEU VAL PRO VAL GLU PRO          
SEQRES  17 T  264  ASP LYS VAL GLU GLU ALA ASN LYS GLY GLU ASN THR SER          
SEQRES  18 T  264  LEU LEU HIS PRO VAL SER LEU HIS GLY MET ASP ASP PRO          
SEQRES  19 T  264  GLU ARG GLU VAL LEU GLU TRP ARG PHE ASP SER ARG LEU          
SEQRES  20 T  264  ALA PHE HIS HIS VAL ALA ARG GLU LEU HIS PRO GLU TYR          
SEQRES  21 T  264  PHE LYS ASN CYS                                              
SEQRES   1 B  570  GLU ILE PHE GLU LEU LYS ALA GLU LEU ASN SER ASP LYS          
SEQRES   2 B  570  LYS GLU LYS LYS LYS GLU ALA VAL LYS LYS VAL ILE ALA          
SEQRES   3 B  570  SER MET THR VAL GLY LYS ASP VAL SER ALA LEU PHE PRO          
SEQRES   4 B  570  ASP VAL VAL ASN CYS MET GLN THR ASP ASN LEU GLU LEU          
SEQRES   5 B  570  LYS LYS LEU VAL TYR LEU TYR LEU MET ASN TYR ALA LYS          
SEQRES   6 B  570  SER GLN PRO ASP MET ALA ILE MET ALA VAL ASN THR PHE          
SEQRES   7 B  570  VAL LYS ASP CYS GLU ASP PRO ASN PRO LEU ILE ARG ALA          
SEQRES   8 B  570  LEU ALA VAL ARG THR MET GLY CYS ILE ARG VAL ASP LYS          
SEQRES   9 B  570  ILE THR GLU TYR LEU CYS GLU PRO LEU ARG LYS CYS LEU          
SEQRES  10 B  570  LYS ASP GLU ASP PRO TYR VAL ARG LYS THR ALA ALA VAL          
SEQRES  11 B  570  CYS VAL ALA LYS LEU HIS ASP ILE ASN ALA GLN LEU VAL          
SEQRES  12 B  570  GLU ASP GLN GLY PHE LEU ASP THR LEU LYS ASP LEU ILE          
SEQRES  13 B  570  SER ASP SER ASN PRO MET VAL VAL ALA ASN ALA VAL ALA          
SEQRES  14 B  570  ALA LEU SER GLU ILE ALA GLU SER HIS PRO SER SER ASN          
SEQRES  15 B  570  LEU LEU ASP LEU ASN PRO GLN SER ILE ASN LYS LEU LEU          
SEQRES  16 B  570  THR ALA LEU ASN GLU CYS THR GLU TRP GLY GLN ILE PHE          
SEQRES  17 B  570  ILE LEU ASP CYS LEU ALA ASN TYR MET PRO LYS ASP ASP          
SEQRES  18 B  570  ARG GLU ALA GLN SER ILE CYS GLU ARG VAL THR PRO ARG          
SEQRES  19 B  570  LEU SER HIS ALA ASN SER ALA VAL VAL LEU SER ALA VAL          
SEQRES  20 B  570  LYS VAL LEU MET LYS PHE MET GLU MET LEU SER LYS ASP          
SEQRES  21 B  570  LEU ASP TYR TYR GLY THR LEU LEU LYS LYS LEU ALA PRO          
SEQRES  22 B  570  PRO LEU VAL THR LEU LEU SER ALA GLU PRO GLU LEU GLN          
SEQRES  23 B  570  TYR VAL ALA LEU ARG ASN ILE ASN LEU ILE VAL GLN LYS          
SEQRES  24 B  570  ARG PRO GLU ILE LEU LYS HIS GLU MET LYS VAL PHE PHE          
SEQRES  25 B  570  VAL LYS TYR ASN ASP PRO ILE TYR VAL LYS LEU GLU LYS          
SEQRES  26 B  570  LEU ASP ILE MET ILE ARG LEU ALA SER GLN ALA ASN ILE          
SEQRES  27 B  570  ALA GLN VAL LEU ALA GLU LEU ARG GLU TYR ALA THR GLU          
SEQRES  28 B  570  VAL ASP VAL ASP PHE VAL ARG LYS ALA VAL ARG ALA ILE          
SEQRES  29 B  570  GLY ARG CYS ALA ILE LYS VAL GLU GLN SER ALA GLU ARG          
SEQRES  30 B  570  CYS VAL SER THR LEU LEU ASP LEU ILE GLN THR LYS VAL          
SEQRES  31 B  570  ASN TYR VAL VAL GLN GLU ALA ILE VAL VAL ILE LYS ASP          
SEQRES  32 B  570  ILE PHE ARG LYS TYR PRO ASN LYS TYR GLU SER VAL ILE          
SEQRES  33 B  570  ALA THR LEU CYS GLU ASN LEU ASP SER LEU ASP GLU PRO          
SEQRES  34 B  570  GLU ALA ARG ALA ALA MET ILE TRP ILE VAL GLY GLU TYR          
SEQRES  35 B  570  ALA GLU ARG ILE ASP ASN ALA ASP GLU LEU LEU GLU SER          
SEQRES  36 B  570  PHE LEU GLU GLY PHE HIS ASP LYS SER THR GLN VAL GLN          
SEQRES  37 B  570  LEU GLN LEU LEU THR ALA ILE VAL LYS LEU PHE LEU LYS          
SEQRES  38 B  570  LYS PRO THR GLU THR GLN GLU LEU VAL GLN GLN VAL LEU          
SEQRES  39 B  570  SER LEU ALA THR GLN ASP SER ASP ASN PRO ASP LEU ARG          
SEQRES  40 B  570  ASP ARG GLY TYR ILE TYR TRP ARG LEU LEU SER THR ASP          
SEQRES  41 B  570  PRO VAL ALA ALA LYS GLU VAL VAL LEU ALA GLU LYS PRO          
SEQRES  42 B  570  LEU ILE SER GLU GLU THR ASP LEU ILE GLU PRO THR LEU          
SEQRES  43 B  570  LEU ASP GLU LEU ILE CYS TYR ILE GLY THR LEU ALA SER          
SEQRES  44 B  570  VAL TYR HIS LYS PRO PRO SER ALA PHE VAL GLU                  
SEQRES   1 C  165  GLU MET ARG ILE LEU MET VAL GLY LEU ASP ALA ALA GLY          
SEQRES   2 C  165  LYS THR THR ILE LEU TYR LYS LEU LYS LEU GLY GLU ILE          
SEQRES   3 C  165  VAL THR THR ILE PRO THR ILE GLY PHE ASN VAL GLU THR          
SEQRES   4 C  165  VAL GLU TYR LYS ASN ILE SER PHE THR VAL TRP ASP VAL          
SEQRES   5 C  165  GLY GLY LEU ASP LYS ILE ARG PRO LEU TRP ARG HIS TYR          
SEQRES   6 C  165  PHE GLN ASN THR GLN GLY LEU ILE PHE VAL VAL ASP SER          
SEQRES   7 C  165  ASN ASP ARG GLU ARG VAL ASN GLU ALA ARG GLU GLU LEU          
SEQRES   8 C  165  MET ARG MET LEU ALA GLU ASP GLU LEU ARG ASP ALA VAL          
SEQRES   9 C  165  LEU LEU VAL PHE ALA ASN LYS GLN ASP LEU PRO ASN ALA          
SEQRES  10 C  165  MET ASN ALA ALA GLU ILE THR ASP LYS LEU GLY LEU HIS          
SEQRES  11 C  165  SER LEU ARG HIS ARG ASN TRP TYR ILE GLN ALA THR CYS          
SEQRES  12 C  165  ALA THR SER GLY ASP GLY LEU TYR GLU GLY LEU ASP TRP          
SEQRES  13 C  165  LEU SER ASN GLN LEU ARG ASN GLN LYS                          
SEQRES   1 G  585  PRO ILE ARG LEU ARG GLU LEU ILE ARG THR ILE ARG THR          
SEQRES   2 G  585  ALA ARG THR GLN ALA GLU GLU ARG GLU MET ILE GLN LYS          
SEQRES   3 G  585  GLU CYS ALA ALA ILE ARG SER SER PHE ARG GLU GLU ASP          
SEQRES   4 G  585  ASN THR TYR ARG CYS ARG ASN VAL ALA LYS LEU LEU TYR          
SEQRES   5 G  585  MET HIS MET LEU GLY TYR PRO ALA HIS PHE GLY GLN LEU          
SEQRES   6 G  585  GLU CYS LEU LYS LEU ILE ALA SER GLN LYS PHE THR ASP          
SEQRES   7 G  585  LYS ARG ILE GLY TYR LEU GLY ALA MET LEU LEU LEU ASP          
SEQRES   8 G  585  GLU ARG GLN ASP VAL HIS LEU LEU MET THR ASN CYS ILE          
SEQRES   9 G  585  LYS ASN ASP LEU ASN HIS SER THR GLN PHE VAL GLN GLY          
SEQRES  10 G  585  LEU ALA LEU CYS THR LEU GLY CYS MET GLY SER SER GLU          
SEQRES  11 G  585  MET CYS ARG ASP LEU ALA GLY GLU VAL GLU LYS LEU LEU          
SEQRES  12 G  585  LYS THR SER ASN SER TYR LEU ARG LYS LYS ALA ALA LEU          
SEQRES  13 G  585  CYS ALA VAL HIS VAL ILE ARG LYS VAL PRO GLU LEU MET          
SEQRES  14 G  585  GLU MET PHE LEU PRO ALA THR LYS ASN LEU LEU ASN GLU          
SEQRES  15 G  585  LYS ASN HIS GLY VAL LEU HIS THR SER VAL VAL LEU LEU          
SEQRES  16 G  585  THR GLU MET CYS GLU ARG SER PRO ASP MET LEU ALA HIS          
SEQRES  17 G  585  PHE ARG LYS LEU VAL PRO GLN LEU VAL ARG ILE LEU LYS          
SEQRES  18 G  585  ASN LEU ILE MET SER GLY TYR SER PRO GLU HIS ASP VAL          
SEQRES  19 G  585  SER GLY ILE SER ASP PRO PHE LEU GLN VAL ARG ILE LEU          
SEQRES  20 G  585  ARG LEU LEU ARG ILE LEU GLY ARG ASN ASP ASP ASP SER          
SEQRES  21 G  585  SER GLU ALA MET ASN ASP ILE LEU ALA GLN VAL ALA THR          
SEQRES  22 G  585  ASN THR GLU THR SER LYS ASN VAL GLY ASN ALA ILE LEU          
SEQRES  23 G  585  TYR GLU THR VAL LEU THR ILE MET ASP ILE LYS SER GLU          
SEQRES  24 G  585  SER GLY LEU ARG VAL LEU ALA ILE ASN ILE LEU GLY ARG          
SEQRES  25 G  585  PHE LEU LEU ASN ASN ASP LYS ASN ILE ARG TYR VAL ALA          
SEQRES  26 G  585  LEU THR SER LEU LEU LYS THR VAL GLN THR ASP HIS ASN          
SEQRES  27 G  585  ALA VAL GLN ARG HIS ARG SER THR ILE VAL ASP CYS LEU          
SEQRES  28 G  585  LYS ASP LEU ASP VAL SER ILE LYS ARG ARG ALA MET GLU          
SEQRES  29 G  585  LEU SER PHE ALA LEU VAL ASN GLY ASN ASN ILE ARG GLY          
SEQRES  30 G  585  MET MET LYS GLU LEU LEU TYR PHE LEU ASP SER CYS GLU          
SEQRES  31 G  585  PRO GLU PHE LYS ALA ASP CYS ALA SER GLY ILE PHE LEU          
SEQRES  32 G  585  ALA ALA GLU LYS TYR ALA PRO SER LYS ARG TRP HIS ILE          
SEQRES  33 G  585  ASP THR ILE MET ARG VAL LEU THR THR ALA GLY SER TYR          
SEQRES  34 G  585  VAL ARG ASP ASP ALA VAL PRO ASN LEU ILE GLN LEU ILE          
SEQRES  35 G  585  THR ASN SER VAL GLU MET HIS ALA TYR THR VAL GLN ARG          
SEQRES  36 G  585  LEU TYR LYS ALA ILE LEU GLY ASP TYR SER GLN GLN PRO          
SEQRES  37 G  585  LEU VAL GLN VAL ALA ALA TRP CYS ILE GLY GLU TYR GLY          
SEQRES  38 G  585  ASP LEU LEU VAL SER GLY GLN CYS GLU GLU GLU GLU PRO          
SEQRES  39 G  585  ILE GLN VAL THR GLU ASP GLU VAL LEU ASP ILE LEU GLU          
SEQRES  40 G  585  SER VAL LEU ILE SER ASN MET SER THR SER VAL THR ARG          
SEQRES  41 G  585  GLY TYR ALA LEU THR ALA ILE MET LYS LEU SER THR ARG          
SEQRES  42 G  585  PHE THR CYS THR VAL ASN ARG ILE LYS LYS VAL VAL SER          
SEQRES  43 G  585  ILE TYR GLY SER SER ILE ASP VAL GLU LEU GLN GLN ARG          
SEQRES  44 G  585  ALA VAL GLU TYR ASN ALA LEU PHE LYS LYS TYR ASP HIS          
SEQRES  45 G  585  MET ARG SER ALA LEU LEU GLU ARG MET PRO VAL MET GLU          
SEQRES   1 H  165  GLU MET ARG ILE LEU MET VAL GLY LEU ASP ALA ALA GLY          
SEQRES   2 H  165  LYS THR THR ILE LEU TYR LYS LEU LYS LEU GLY GLU ILE          
SEQRES   3 H  165  VAL THR THR ILE PRO THR ILE GLY PHE ASN VAL GLU THR          
SEQRES   4 H  165  VAL GLU TYR LYS ASN ILE SER PHE THR VAL TRP ASP VAL          
SEQRES   5 H  165  GLY GLY LEU ASP LYS ILE ARG PRO LEU TRP ARG HIS TYR          
SEQRES   6 H  165  PHE GLN ASN THR GLN GLY LEU ILE PHE VAL VAL ASP SER          
SEQRES   7 H  165  ASN ASP ARG GLU ARG VAL ASN GLU ALA ARG GLU GLU LEU          
SEQRES   8 H  165  MET ARG MET LEU ALA GLU ASP GLU LEU ARG ASP ALA VAL          
SEQRES   9 H  165  LEU LEU VAL PHE ALA ASN LYS GLN ASP LEU PRO ASN ALA          
SEQRES  10 H  165  MET ASN ALA ALA GLU ILE THR ASP LYS LEU GLY LEU HIS          
SEQRES  11 H  165  SER LEU ARG HIS ARG ASN TRP TYR ILE GLN ALA THR CYS          
SEQRES  12 H  165  ALA THR SER GLY ASP GLY LEU TYR GLU GLY LEU ASP TRP          
SEQRES  13 H  165  LEU SER ASN GLN LEU ARG ASN GLN LYS                          
SEQRES   1 M  422  SER ALA SER ALA VAL TYR VAL LEU ASP LEU LYS GLY LYS          
SEQRES   2 M  422  VAL LEU ILE CYS ARG ASN TYR ARG GLY ASP VAL ASP MET          
SEQRES   3 M  422  SER GLU VAL GLU HIS PHE MET PRO ILE LEU MET GLU LYS          
SEQRES   4 M  422  GLU GLU GLU GLY MET LEU SER PRO ILE LEU ALA HIS GLY          
SEQRES   5 M  422  GLY VAL ARG PHE MET TRP ILE LYS HIS ASN ASN LEU TYR          
SEQRES   6 M  422  LEU VAL ALA THR SER LYS LYS ASN ALA CYS VAL SER LEU          
SEQRES   7 M  422  VAL PHE SER PHE LEU TYR LYS VAL VAL GLN VAL PHE SER          
SEQRES   8 M  422  GLU TYR PHE LYS GLU LEU GLU GLU GLU SER ILE ARG ASP          
SEQRES   9 M  422  ASN PHE VAL ILE ILE TYR GLU LEU LEU ASP GLU LEU MET          
SEQRES  10 M  422  ASP PHE GLY TYR PRO GLN THR THR ASP SER LYS ILE LEU          
SEQRES  11 M  422  GLN GLU TYR ILE THR GLN GLU GLY HIS LYS LEU GLU THR          
SEQRES  12 M  422  GLY ALA PRO ARG PRO PRO ALA THR VAL THR ASN ALA VAL          
SEQRES  13 M  422  SER TRP ARG SER GLU GLY ILE LYS TYR ARG LYS ASN GLU          
SEQRES  14 M  422  VAL PHE LEU ASP VAL ILE GLU ALA VAL ASN LEU LEU VAL          
SEQRES  15 M  422  SER ALA ASN GLY ASN VAL LEU ARG SER GLU ILE VAL GLY          
SEQRES  16 M  422  SER ILE LYS MET ARG VAL PHE LEU SER GLY MET PRO GLU          
SEQRES  17 M  422  LEU ARG LEU GLY LEU ASN ASP LYS VAL LEU PHE ASP ASN          
SEQRES  18 M  422  THR GLY ARG GLY LYS SER LYS SER VAL GLU LEU GLU ASP          
SEQRES  19 M  422  VAL LYS PHE HIS GLN CYS VAL ARG LEU SER ARG PHE GLU          
SEQRES  20 M  422  ASN ASP ARG THR ILE SER PHE ILE PRO PRO ASP GLY GLU          
SEQRES  21 M  422  PHE GLU LEU MET SER TYR ARG LEU ASN THR HIS VAL LYS          
SEQRES  22 M  422  PRO LEU ILE TRP ILE GLU SER VAL ILE GLU LYS HIS SER          
SEQRES  23 M  422  HIS SER ARG ILE GLU TYR MET VAL LYS ALA LYS SER GLN          
SEQRES  24 M  422  PHE LYS ARG ARG SER THR ALA ASN ASN VAL GLU ILE HIS          
SEQRES  25 M  422  ILE PRO VAL PRO ASN ASP ALA ASP SER PRO LYS PHE LYS          
SEQRES  26 M  422  THR THR VAL GLY SER VAL LYS TRP VAL PRO GLU ASN SER          
SEQRES  27 M  422  GLU ILE VAL TRP SER VAL LYS SER PHE PRO GLY GLY LYS          
SEQRES  28 M  422  GLU TYR LEU MET ARG ALA HIS PHE GLY LEU PRO SER VAL          
SEQRES  29 M  422  GLU ALA GLU ASP LYS GLU GLY LYS PRO PRO ILE SER VAL          
SEQRES  30 M  422  LYS PHE GLU ILE PRO TYR PHE THR THR SER GLY ILE GLN          
SEQRES  31 M  422  VAL ARG TYR LEU LYS ILE ILE GLU LYS SER GLY TYR GLN          
SEQRES  32 M  422  ALA LEU PRO TRP VAL ARG TYR ILE THR GLN ASN GLY ASP          
SEQRES  33 M  422  TYR GLN LEU ARG THR GLN                                      
SEQRES   1 S  142  MET ILE HIS PHE ILE LEU LEU PHE SER ARG GLN GLY LYS          
SEQRES   2 S  142  LEU ARG LEU GLN LYS TRP TYR ILE THR LEU PRO ASP LYS          
SEQRES   3 S  142  GLU ARG LYS LYS ILE THR ARG GLU ILE VAL GLN ILE ILE          
SEQRES   4 S  142  LEU SER ARG GLY HIS ARG THR SER SER PHE VAL ASP TRP          
SEQRES   5 S  142  LYS GLU LEU LYS LEU VAL TYR LYS ARG TYR ALA SER LEU          
SEQRES   6 S  142  TYR PHE CYS CYS ALA ILE GLU ASN GLN ASP ASN GLU LEU          
SEQRES   7 S  142  LEU THR LEU GLU ILE VAL HIS ARG TYR VAL GLU LEU LEU          
SEQRES   8 S  142  ASP LYS TYR PHE GLY ASN VAL CYS GLU LEU ASP ILE ILE          
SEQRES   9 S  142  PHE ASN PHE GLU LYS ALA TYR PHE ILE LEU ASP GLU PHE          
SEQRES  10 S  142  ILE ILE GLY GLY GLU ILE GLN GLU THR SER LYS LYS ILE          
SEQRES  11 S  142  ALA VAL LYS ALA ILE GLU ASP SER ASP MET LEU GLN              
SEQRES   1 N  264  MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP          
SEQRES   2 N  264  ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET          
SEQRES   3 N  264  GLY SER ALA SER THR SER TYR ASP TYR CYS ARG VAL PRO          
SEQRES   4 N  264  MET GLU ASP GLY ASP LYS ARG CYS LYS GLY SER ASP GLU          
SEQRES   5 N  264  ALA SER GLU GLY SER GLY MET GLY GLY LYS TRP SER LYS          
SEQRES   6 N  264  SER SER VAL ILE GLY TRP PRO ALA VAL ARG GLU ARG MET          
SEQRES   7 N  264  ARG ARG ALA GLU PRO ALA ALA ASP GLY VAL GLY ALA VAL          
SEQRES   8 N  264  SER ARG ASP LEU GLU LYS HIS GLY ALA ILE THR SER SER          
SEQRES   9 N  264  ASN THR ALA ALA ASN ASN ALA ALA CYS ALA TRP LEU GLU          
SEQRES  10 N  264  ALA GLN GLU GLU GLU GLU VAL GLY PHE PRO VAL THR PRO          
SEQRES  11 N  264  GLN VAL PRO LEU ARG PRO MET THR TYR LYS ALA ALA VAL          
SEQRES  12 N  264  ASP LEU SER HIS PHE LEU LYS GLU LYS GLY GLY LEU GLU          
SEQRES  13 N  264  GLY LEU ILE HIS SER GLN ARG ARG GLN ASP ILE LEU ASP          
SEQRES  14 N  264  LEU TRP ILE TYR HIS THR GLN GLY TYR PHE PRO ASP TRP          
SEQRES  15 N  264  GLN ASN TYR THR PRO GLY PRO GLY VAL ARG TYR PRO LEU          
SEQRES  16 N  264  THR PHE GLY TRP CYS TYR LYS LEU VAL PRO VAL GLU PRO          
SEQRES  17 N  264  ASP LYS VAL GLU GLU ALA ASN LYS GLY GLU ASN THR SER          
SEQRES  18 N  264  LEU LEU HIS PRO VAL SER LEU HIS GLY MET ASP ASP PRO          
SEQRES  19 N  264  GLU ARG GLU VAL LEU GLU TRP ARG PHE ASP SER ARG LEU          
SEQRES  20 N  264  ALA PHE HIS HIS VAL ALA ARG GLU LEU HIS PRO GLU TYR          
SEQRES  21 N  264  PHE LYS ASN CYS                                              
SEQRES   1 c  264  MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP          
SEQRES   2 c  264  ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET          
SEQRES   3 c  264  GLY SER ALA SER THR SER TYR ASP TYR CYS ARG VAL PRO          
SEQRES   4 c  264  MET GLU ASP GLY ASP LYS ARG CYS LYS GLY SER ASP GLU          
SEQRES   5 c  264  ALA SER GLU GLY SER GLY MET GLY GLY LYS TRP SER LYS          
SEQRES   6 c  264  SER SER VAL ILE GLY TRP PRO ALA VAL ARG GLU ARG MET          
SEQRES   7 c  264  ARG ARG ALA GLU PRO ALA ALA ASP GLY VAL GLY ALA VAL          
SEQRES   8 c  264  SER ARG ASP LEU GLU LYS HIS GLY ALA ILE THR SER SER          
SEQRES   9 c  264  ASN THR ALA ALA ASN ASN ALA ALA CYS ALA TRP LEU GLU          
SEQRES  10 c  264  ALA GLN GLU GLU GLU GLU VAL GLY PHE PRO VAL THR PRO          
SEQRES  11 c  264  GLN VAL PRO LEU ARG PRO MET THR TYR LYS ALA ALA VAL          
SEQRES  12 c  264  ASP LEU SER HIS PHE LEU LYS GLU LYS GLY GLY LEU GLU          
SEQRES  13 c  264  GLY LEU ILE HIS SER GLN ARG ARG GLN ASP ILE LEU ASP          
SEQRES  14 c  264  LEU TRP ILE TYR HIS THR GLN GLY TYR PHE PRO ASP TRP          
SEQRES  15 c  264  GLN ASN TYR THR PRO GLY PRO GLY VAL ARG TYR PRO LEU          
SEQRES  16 c  264  THR PHE GLY TRP CYS TYR LYS LEU VAL PRO VAL GLU PRO          
SEQRES  17 c  264  ASP LYS VAL GLU GLU ALA ASN LYS GLY GLU ASN THR SER          
SEQRES  18 c  264  LEU LEU HIS PRO VAL SER LEU HIS GLY MET ASP ASP PRO          
SEQRES  19 c  264  GLU ARG GLU VAL LEU GLU TRP ARG PHE ASP SER ARG LEU          
SEQRES  20 c  264  ALA PHE HIS HIS VAL ALA ARG GLU LEU HIS PRO GLU TYR          
SEQRES  21 c  264  PHE LYS ASN CYS                                              
SEQRES   1 I  570  GLU ILE PHE GLU LEU LYS ALA GLU LEU ASN SER ASP LYS          
SEQRES   2 I  570  LYS GLU LYS LYS LYS GLU ALA VAL LYS LYS VAL ILE ALA          
SEQRES   3 I  570  SER MET THR VAL GLY LYS ASP VAL SER ALA LEU PHE PRO          
SEQRES   4 I  570  ASP VAL VAL ASN CYS MET GLN THR ASP ASN LEU GLU LEU          
SEQRES   5 I  570  LYS LYS LEU VAL TYR LEU TYR LEU MET ASN TYR ALA LYS          
SEQRES   6 I  570  SER GLN PRO ASP MET ALA ILE MET ALA VAL ASN THR PHE          
SEQRES   7 I  570  VAL LYS ASP CYS GLU ASP PRO ASN PRO LEU ILE ARG ALA          
SEQRES   8 I  570  LEU ALA VAL ARG THR MET GLY CYS ILE ARG VAL ASP LYS          
SEQRES   9 I  570  ILE THR GLU TYR LEU CYS GLU PRO LEU ARG LYS CYS LEU          
SEQRES  10 I  570  LYS ASP GLU ASP PRO TYR VAL ARG LYS THR ALA ALA VAL          
SEQRES  11 I  570  CYS VAL ALA LYS LEU HIS ASP ILE ASN ALA GLN LEU VAL          
SEQRES  12 I  570  GLU ASP GLN GLY PHE LEU ASP THR LEU LYS ASP LEU ILE          
SEQRES  13 I  570  SER ASP SER ASN PRO MET VAL VAL ALA ASN ALA VAL ALA          
SEQRES  14 I  570  ALA LEU SER GLU ILE ALA GLU SER HIS PRO SER SER ASN          
SEQRES  15 I  570  LEU LEU ASP LEU ASN PRO GLN SER ILE ASN LYS LEU LEU          
SEQRES  16 I  570  THR ALA LEU ASN GLU CYS THR GLU TRP GLY GLN ILE PHE          
SEQRES  17 I  570  ILE LEU ASP CYS LEU ALA ASN TYR MET PRO LYS ASP ASP          
SEQRES  18 I  570  ARG GLU ALA GLN SER ILE CYS GLU ARG VAL THR PRO ARG          
SEQRES  19 I  570  LEU SER HIS ALA ASN SER ALA VAL VAL LEU SER ALA VAL          
SEQRES  20 I  570  LYS VAL LEU MET LYS PHE MET GLU MET LEU SER LYS ASP          
SEQRES  21 I  570  LEU ASP TYR TYR GLY THR LEU LEU LYS LYS LEU ALA PRO          
SEQRES  22 I  570  PRO LEU VAL THR LEU LEU SER ALA GLU PRO GLU LEU GLN          
SEQRES  23 I  570  TYR VAL ALA LEU ARG ASN ILE ASN LEU ILE VAL GLN LYS          
SEQRES  24 I  570  ARG PRO GLU ILE LEU LYS HIS GLU MET LYS VAL PHE PHE          
SEQRES  25 I  570  VAL LYS TYR ASN ASP PRO ILE TYR VAL LYS LEU GLU LYS          
SEQRES  26 I  570  LEU ASP ILE MET ILE ARG LEU ALA SER GLN ALA ASN ILE          
SEQRES  27 I  570  ALA GLN VAL LEU ALA GLU LEU ARG GLU TYR ALA THR GLU          
SEQRES  28 I  570  VAL ASP VAL ASP PHE VAL ARG LYS ALA VAL ARG ALA ILE          
SEQRES  29 I  570  GLY ARG CYS ALA ILE LYS VAL GLU GLN SER ALA GLU ARG          
SEQRES  30 I  570  CYS VAL SER THR LEU LEU ASP LEU ILE GLN THR LYS VAL          
SEQRES  31 I  570  ASN TYR VAL VAL GLN GLU ALA ILE VAL VAL ILE LYS ASP          
SEQRES  32 I  570  ILE PHE ARG LYS TYR PRO ASN LYS TYR GLU SER VAL ILE          
SEQRES  33 I  570  ALA THR LEU CYS GLU ASN LEU ASP SER LEU ASP GLU PRO          
SEQRES  34 I  570  GLU ALA ARG ALA ALA MET ILE TRP ILE VAL GLY GLU TYR          
SEQRES  35 I  570  ALA GLU ARG ILE ASP ASN ALA ASP GLU LEU LEU GLU SER          
SEQRES  36 I  570  PHE LEU GLU GLY PHE HIS ASP LYS SER THR GLN VAL GLN          
SEQRES  37 I  570  LEU GLN LEU LEU THR ALA ILE VAL LYS LEU PHE LEU LYS          
SEQRES  38 I  570  LYS PRO THR GLU THR GLN GLU LEU VAL GLN GLN VAL LEU          
SEQRES  39 I  570  SER LEU ALA THR GLN ASP SER ASP ASN PRO ASP LEU ARG          
SEQRES  40 I  570  ASP ARG GLY TYR ILE TYR TRP ARG LEU LEU SER THR ASP          
SEQRES  41 I  570  PRO VAL ALA ALA LYS GLU VAL VAL LEU ALA GLU LYS PRO          
SEQRES  42 I  570  LEU ILE SER GLU GLU THR ASP LEU ILE GLU PRO THR LEU          
SEQRES  43 I  570  LEU ASP GLU LEU ILE CYS TYR ILE GLY THR LEU ALA SER          
SEQRES  44 I  570  VAL TYR HIS LYS PRO PRO SER ALA PHE VAL GLU                  
SEQRES   1 K  165  GLU MET ARG ILE LEU MET VAL GLY LEU ASP ALA ALA GLY          
SEQRES   2 K  165  LYS THR THR ILE LEU TYR LYS LEU LYS LEU GLY GLU ILE          
SEQRES   3 K  165  VAL THR THR ILE PRO THR ILE GLY PHE ASN VAL GLU THR          
SEQRES   4 K  165  VAL GLU TYR LYS ASN ILE SER PHE THR VAL TRP ASP VAL          
SEQRES   5 K  165  GLY GLY LEU ASP LYS ILE ARG PRO LEU TRP ARG HIS TYR          
SEQRES   6 K  165  PHE GLN ASN THR GLN GLY LEU ILE PHE VAL VAL ASP SER          
SEQRES   7 K  165  ASN ASP ARG GLU ARG VAL ASN GLU ALA ARG GLU GLU LEU          
SEQRES   8 K  165  MET ARG MET LEU ALA GLU ASP GLU LEU ARG ASP ALA VAL          
SEQRES   9 K  165  LEU LEU VAL PHE ALA ASN LYS GLN ASP LEU PRO ASN ALA          
SEQRES  10 K  165  MET ASN ALA ALA GLU ILE THR ASP LYS LEU GLY LEU HIS          
SEQRES  11 K  165  SER LEU ARG HIS ARG ASN TRP TYR ILE GLN ALA THR CYS          
SEQRES  12 K  165  ALA THR SER GLY ASP GLY LEU TYR GLU GLY LEU ASP TRP          
SEQRES  13 K  165  LEU SER ASN GLN LEU ARG ASN GLN LYS                          
SEQRES   1 Q  585  PRO ILE ARG LEU ARG GLU LEU ILE ARG THR ILE ARG THR          
SEQRES   2 Q  585  ALA ARG THR GLN ALA GLU GLU ARG GLU MET ILE GLN LYS          
SEQRES   3 Q  585  GLU CYS ALA ALA ILE ARG SER SER PHE ARG GLU GLU ASP          
SEQRES   4 Q  585  ASN THR TYR ARG CYS ARG ASN VAL ALA LYS LEU LEU TYR          
SEQRES   5 Q  585  MET HIS MET LEU GLY TYR PRO ALA HIS PHE GLY GLN LEU          
SEQRES   6 Q  585  GLU CYS LEU LYS LEU ILE ALA SER GLN LYS PHE THR ASP          
SEQRES   7 Q  585  LYS ARG ILE GLY TYR LEU GLY ALA MET LEU LEU LEU ASP          
SEQRES   8 Q  585  GLU ARG GLN ASP VAL HIS LEU LEU MET THR ASN CYS ILE          
SEQRES   9 Q  585  LYS ASN ASP LEU ASN HIS SER THR GLN PHE VAL GLN GLY          
SEQRES  10 Q  585  LEU ALA LEU CYS THR LEU GLY CYS MET GLY SER SER GLU          
SEQRES  11 Q  585  MET CYS ARG ASP LEU ALA GLY GLU VAL GLU LYS LEU LEU          
SEQRES  12 Q  585  LYS THR SER ASN SER TYR LEU ARG LYS LYS ALA ALA LEU          
SEQRES  13 Q  585  CYS ALA VAL HIS VAL ILE ARG LYS VAL PRO GLU LEU MET          
SEQRES  14 Q  585  GLU MET PHE LEU PRO ALA THR LYS ASN LEU LEU ASN GLU          
SEQRES  15 Q  585  LYS ASN HIS GLY VAL LEU HIS THR SER VAL VAL LEU LEU          
SEQRES  16 Q  585  THR GLU MET CYS GLU ARG SER PRO ASP MET LEU ALA HIS          
SEQRES  17 Q  585  PHE ARG LYS LEU VAL PRO GLN LEU VAL ARG ILE LEU LYS          
SEQRES  18 Q  585  ASN LEU ILE MET SER GLY TYR SER PRO GLU HIS ASP VAL          
SEQRES  19 Q  585  SER GLY ILE SER ASP PRO PHE LEU GLN VAL ARG ILE LEU          
SEQRES  20 Q  585  ARG LEU LEU ARG ILE LEU GLY ARG ASN ASP ASP ASP SER          
SEQRES  21 Q  585  SER GLU ALA MET ASN ASP ILE LEU ALA GLN VAL ALA THR          
SEQRES  22 Q  585  ASN THR GLU THR SER LYS ASN VAL GLY ASN ALA ILE LEU          
SEQRES  23 Q  585  TYR GLU THR VAL LEU THR ILE MET ASP ILE LYS SER GLU          
SEQRES  24 Q  585  SER GLY LEU ARG VAL LEU ALA ILE ASN ILE LEU GLY ARG          
SEQRES  25 Q  585  PHE LEU LEU ASN ASN ASP LYS ASN ILE ARG TYR VAL ALA          
SEQRES  26 Q  585  LEU THR SER LEU LEU LYS THR VAL GLN THR ASP HIS ASN          
SEQRES  27 Q  585  ALA VAL GLN ARG HIS ARG SER THR ILE VAL ASP CYS LEU          
SEQRES  28 Q  585  LYS ASP LEU ASP VAL SER ILE LYS ARG ARG ALA MET GLU          
SEQRES  29 Q  585  LEU SER PHE ALA LEU VAL ASN GLY ASN ASN ILE ARG GLY          
SEQRES  30 Q  585  MET MET LYS GLU LEU LEU TYR PHE LEU ASP SER CYS GLU          
SEQRES  31 Q  585  PRO GLU PHE LYS ALA ASP CYS ALA SER GLY ILE PHE LEU          
SEQRES  32 Q  585  ALA ALA GLU LYS TYR ALA PRO SER LYS ARG TRP HIS ILE          
SEQRES  33 Q  585  ASP THR ILE MET ARG VAL LEU THR THR ALA GLY SER TYR          
SEQRES  34 Q  585  VAL ARG ASP ASP ALA VAL PRO ASN LEU ILE GLN LEU ILE          
SEQRES  35 Q  585  THR ASN SER VAL GLU MET HIS ALA TYR THR VAL GLN ARG          
SEQRES  36 Q  585  LEU TYR LYS ALA ILE LEU GLY ASP TYR SER GLN GLN PRO          
SEQRES  37 Q  585  LEU VAL GLN VAL ALA ALA TRP CYS ILE GLY GLU TYR GLY          
SEQRES  38 Q  585  ASP LEU LEU VAL SER GLY GLN CYS GLU GLU GLU GLU PRO          
SEQRES  39 Q  585  ILE GLN VAL THR GLU ASP GLU VAL LEU ASP ILE LEU GLU          
SEQRES  40 Q  585  SER VAL LEU ILE SER ASN MET SER THR SER VAL THR ARG          
SEQRES  41 Q  585  GLY TYR ALA LEU THR ALA ILE MET LYS LEU SER THR ARG          
SEQRES  42 Q  585  PHE THR CYS THR VAL ASN ARG ILE LYS LYS VAL VAL SER          
SEQRES  43 Q  585  ILE TYR GLY SER SER ILE ASP VAL GLU LEU GLN GLN ARG          
SEQRES  44 Q  585  ALA VAL GLU TYR ASN ALA LEU PHE LYS LYS TYR ASP HIS          
SEQRES  45 Q  585  MET ARG SER ALA LEU LEU GLU ARG MET PRO VAL MET GLU          
SEQRES   1 U  165  GLU MET ARG ILE LEU MET VAL GLY LEU ASP ALA ALA GLY          
SEQRES   2 U  165  LYS THR THR ILE LEU TYR LYS LEU LYS LEU GLY GLU ILE          
SEQRES   3 U  165  VAL THR THR ILE PRO THR ILE GLY PHE ASN VAL GLU THR          
SEQRES   4 U  165  VAL GLU TYR LYS ASN ILE SER PHE THR VAL TRP ASP VAL          
SEQRES   5 U  165  GLY GLY LEU ASP LYS ILE ARG PRO LEU TRP ARG HIS TYR          
SEQRES   6 U  165  PHE GLN ASN THR GLN GLY LEU ILE PHE VAL VAL ASP SER          
SEQRES   7 U  165  ASN ASP ARG GLU ARG VAL ASN GLU ALA ARG GLU GLU LEU          
SEQRES   8 U  165  MET ARG MET LEU ALA GLU ASP GLU LEU ARG ASP ALA VAL          
SEQRES   9 U  165  LEU LEU VAL PHE ALA ASN LYS GLN ASP LEU PRO ASN ALA          
SEQRES  10 U  165  MET ASN ALA ALA GLU ILE THR ASP LYS LEU GLY LEU HIS          
SEQRES  11 U  165  SER LEU ARG HIS ARG ASN TRP TYR ILE GLN ALA THR CYS          
SEQRES  12 U  165  ALA THR SER GLY ASP GLY LEU TYR GLU GLY LEU ASP TRP          
SEQRES  13 U  165  LEU SER ASN GLN LEU ARG ASN GLN LYS                          
SEQRES   1 W  422  SER ALA SER ALA VAL TYR VAL LEU ASP LEU LYS GLY LYS          
SEQRES   2 W  422  VAL LEU ILE CYS ARG ASN TYR ARG GLY ASP VAL ASP MET          
SEQRES   3 W  422  SER GLU VAL GLU HIS PHE MET PRO ILE LEU MET GLU LYS          
SEQRES   4 W  422  GLU GLU GLU GLY MET LEU SER PRO ILE LEU ALA HIS GLY          
SEQRES   5 W  422  GLY VAL ARG PHE MET TRP ILE LYS HIS ASN ASN LEU TYR          
SEQRES   6 W  422  LEU VAL ALA THR SER LYS LYS ASN ALA CYS VAL SER LEU          
SEQRES   7 W  422  VAL PHE SER PHE LEU TYR LYS VAL VAL GLN VAL PHE SER          
SEQRES   8 W  422  GLU TYR PHE LYS GLU LEU GLU GLU GLU SER ILE ARG ASP          
SEQRES   9 W  422  ASN PHE VAL ILE ILE TYR GLU LEU LEU ASP GLU LEU MET          
SEQRES  10 W  422  ASP PHE GLY TYR PRO GLN THR THR ASP SER LYS ILE LEU          
SEQRES  11 W  422  GLN GLU TYR ILE THR GLN GLU GLY HIS LYS LEU GLU THR          
SEQRES  12 W  422  GLY ALA PRO ARG PRO PRO ALA THR VAL THR ASN ALA VAL          
SEQRES  13 W  422  SER TRP ARG SER GLU GLY ILE LYS TYR ARG LYS ASN GLU          
SEQRES  14 W  422  VAL PHE LEU ASP VAL ILE GLU ALA VAL ASN LEU LEU VAL          
SEQRES  15 W  422  SER ALA ASN GLY ASN VAL LEU ARG SER GLU ILE VAL GLY          
SEQRES  16 W  422  SER ILE LYS MET ARG VAL PHE LEU SER GLY MET PRO GLU          
SEQRES  17 W  422  LEU ARG LEU GLY LEU ASN ASP LYS VAL LEU PHE ASP ASN          
SEQRES  18 W  422  THR GLY ARG GLY LYS SER LYS SER VAL GLU LEU GLU ASP          
SEQRES  19 W  422  VAL LYS PHE HIS GLN CYS VAL ARG LEU SER ARG PHE GLU          
SEQRES  20 W  422  ASN ASP ARG THR ILE SER PHE ILE PRO PRO ASP GLY GLU          
SEQRES  21 W  422  PHE GLU LEU MET SER TYR ARG LEU ASN THR HIS VAL LYS          
SEQRES  22 W  422  PRO LEU ILE TRP ILE GLU SER VAL ILE GLU LYS HIS SER          
SEQRES  23 W  422  HIS SER ARG ILE GLU TYR MET VAL LYS ALA LYS SER GLN          
SEQRES  24 W  422  PHE LYS ARG ARG SER THR ALA ASN ASN VAL GLU ILE HIS          
SEQRES  25 W  422  ILE PRO VAL PRO ASN ASP ALA ASP SER PRO LYS PHE LYS          
SEQRES  26 W  422  THR THR VAL GLY SER VAL LYS TRP VAL PRO GLU ASN SER          
SEQRES  27 W  422  GLU ILE VAL TRP SER VAL LYS SER PHE PRO GLY GLY LYS          
SEQRES  28 W  422  GLU TYR LEU MET ARG ALA HIS PHE GLY LEU PRO SER VAL          
SEQRES  29 W  422  GLU ALA GLU ASP LYS GLU GLY LYS PRO PRO ILE SER VAL          
SEQRES  30 W  422  LYS PHE GLU ILE PRO TYR PHE THR THR SER GLY ILE GLN          
SEQRES  31 W  422  VAL ARG TYR LEU LYS ILE ILE GLU LYS SER GLY TYR GLN          
SEQRES  32 W  422  ALA LEU PRO TRP VAL ARG TYR ILE THR GLN ASN GLY ASP          
SEQRES  33 W  422  TYR GLN LEU ARG THR GLN                                      
SEQRES   1 a  142  MET ILE HIS PHE ILE LEU LEU PHE SER ARG GLN GLY LYS          
SEQRES   2 a  142  LEU ARG LEU GLN LYS TRP TYR ILE THR LEU PRO ASP LYS          
SEQRES   3 a  142  GLU ARG LYS LYS ILE THR ARG GLU ILE VAL GLN ILE ILE          
SEQRES   4 a  142  LEU SER ARG GLY HIS ARG THR SER SER PHE VAL ASP TRP          
SEQRES   5 a  142  LYS GLU LEU LYS LEU VAL TYR LYS ARG TYR ALA SER LEU          
SEQRES   6 a  142  TYR PHE CYS CYS ALA ILE GLU ASN GLN ASP ASN GLU LEU          
SEQRES   7 a  142  LEU THR LEU GLU ILE VAL HIS ARG TYR VAL GLU LEU LEU          
SEQRES   8 a  142  ASP LYS TYR PHE GLY ASN VAL CYS GLU LEU ASP ILE ILE          
SEQRES   9 a  142  PHE ASN PHE GLU LYS ALA TYR PHE ILE LEU ASP GLU PHE          
SEQRES  10 a  142  ILE ILE GLY GLY GLU ILE GLN GLU THR SER LYS LYS ILE          
SEQRES  11 a  142  ALA VAL LYS ALA ILE GLU ASP SER ASP MET LEU GLN              
SEQRES   1 Y  264  MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP          
SEQRES   2 Y  264  ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET          
SEQRES   3 Y  264  GLY SER ALA SER THR SER TYR ASP TYR CYS ARG VAL PRO          
SEQRES   4 Y  264  MET GLU ASP GLY ASP LYS ARG CYS LYS GLY SER ASP GLU          
SEQRES   5 Y  264  ALA SER GLU GLY SER GLY MET GLY GLY LYS TRP SER LYS          
SEQRES   6 Y  264  SER SER VAL ILE GLY TRP PRO ALA VAL ARG GLU ARG MET          
SEQRES   7 Y  264  ARG ARG ALA GLU PRO ALA ALA ASP GLY VAL GLY ALA VAL          
SEQRES   8 Y  264  SER ARG ASP LEU GLU LYS HIS GLY ALA ILE THR SER SER          
SEQRES   9 Y  264  ASN THR ALA ALA ASN ASN ALA ALA CYS ALA TRP LEU GLU          
SEQRES  10 Y  264  ALA GLN GLU GLU GLU GLU VAL GLY PHE PRO VAL THR PRO          
SEQRES  11 Y  264  GLN VAL PRO LEU ARG PRO MET THR TYR LYS ALA ALA VAL          
SEQRES  12 Y  264  ASP LEU SER HIS PHE LEU LYS GLU LYS GLY GLY LEU GLU          
SEQRES  13 Y  264  GLY LEU ILE HIS SER GLN ARG ARG GLN ASP ILE LEU ASP          
SEQRES  14 Y  264  LEU TRP ILE TYR HIS THR GLN GLY TYR PHE PRO ASP TRP          
SEQRES  15 Y  264  GLN ASN TYR THR PRO GLY PRO GLY VAL ARG TYR PRO LEU          
SEQRES  16 Y  264  THR PHE GLY TRP CYS TYR LYS LEU VAL PRO VAL GLU PRO          
SEQRES  17 Y  264  ASP LYS VAL GLU GLU ALA ASN LYS GLY GLU ASN THR SER          
SEQRES  18 Y  264  LEU LEU HIS PRO VAL SER LEU HIS GLY MET ASP ASP PRO          
SEQRES  19 Y  264  GLU ARG GLU VAL LEU GLU TRP ARG PHE ASP SER ARG LEU          
SEQRES  20 Y  264  ALA PHE HIS HIS VAL ALA ARG GLU LEU HIS PRO GLU TYR          
SEQRES  21 Y  264  PHE LYS ASN CYS                                              
SEQRES   1 d  264  MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP          
SEQRES   2 d  264  ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET          
SEQRES   3 d  264  GLY SER ALA SER THR SER TYR ASP TYR CYS ARG VAL PRO          
SEQRES   4 d  264  MET GLU ASP GLY ASP LYS ARG CYS LYS GLY SER ASP GLU          
SEQRES   5 d  264  ALA SER GLU GLY SER GLY MET GLY GLY LYS TRP SER LYS          
SEQRES   6 d  264  SER SER VAL ILE GLY TRP PRO ALA VAL ARG GLU ARG MET          
SEQRES   7 d  264  ARG ARG ALA GLU PRO ALA ALA ASP GLY VAL GLY ALA VAL          
SEQRES   8 d  264  SER ARG ASP LEU GLU LYS HIS GLY ALA ILE THR SER SER          
SEQRES   9 d  264  ASN THR ALA ALA ASN ASN ALA ALA CYS ALA TRP LEU GLU          
SEQRES  10 d  264  ALA GLN GLU GLU GLU GLU VAL GLY PHE PRO VAL THR PRO          
SEQRES  11 d  264  GLN VAL PRO LEU ARG PRO MET THR TYR LYS ALA ALA VAL          
SEQRES  12 d  264  ASP LEU SER HIS PHE LEU LYS GLU LYS GLY GLY LEU GLU          
SEQRES  13 d  264  GLY LEU ILE HIS SER GLN ARG ARG GLN ASP ILE LEU ASP          
SEQRES  14 d  264  LEU TRP ILE TYR HIS THR GLN GLY TYR PHE PRO ASP TRP          
SEQRES  15 d  264  GLN ASN TYR THR PRO GLY PRO GLY VAL ARG TYR PRO LEU          
SEQRES  16 d  264  THR PHE GLY TRP CYS TYR LYS LEU VAL PRO VAL GLU PRO          
SEQRES  17 d  264  ASP LYS VAL GLU GLU ALA ASN LYS GLY GLU ASN THR SER          
SEQRES  18 d  264  LEU LEU HIS PRO VAL SER LEU HIS GLY MET ASP ASP PRO          
SEQRES  19 d  264  GLU ARG GLU VAL LEU GLU TRP ARG PHE ASP SER ARG LEU          
SEQRES  20 d  264  ALA PHE HIS HIS VAL ALA ARG GLU LEU HIS PRO GLU TYR          
SEQRES  21 d  264  PHE LYS ASN CYS                                              
SEQRES   1 J  570  GLU ILE PHE GLU LEU LYS ALA GLU LEU ASN SER ASP LYS          
SEQRES   2 J  570  LYS GLU LYS LYS LYS GLU ALA VAL LYS LYS VAL ILE ALA          
SEQRES   3 J  570  SER MET THR VAL GLY LYS ASP VAL SER ALA LEU PHE PRO          
SEQRES   4 J  570  ASP VAL VAL ASN CYS MET GLN THR ASP ASN LEU GLU LEU          
SEQRES   5 J  570  LYS LYS LEU VAL TYR LEU TYR LEU MET ASN TYR ALA LYS          
SEQRES   6 J  570  SER GLN PRO ASP MET ALA ILE MET ALA VAL ASN THR PHE          
SEQRES   7 J  570  VAL LYS ASP CYS GLU ASP PRO ASN PRO LEU ILE ARG ALA          
SEQRES   8 J  570  LEU ALA VAL ARG THR MET GLY CYS ILE ARG VAL ASP LYS          
SEQRES   9 J  570  ILE THR GLU TYR LEU CYS GLU PRO LEU ARG LYS CYS LEU          
SEQRES  10 J  570  LYS ASP GLU ASP PRO TYR VAL ARG LYS THR ALA ALA VAL          
SEQRES  11 J  570  CYS VAL ALA LYS LEU HIS ASP ILE ASN ALA GLN LEU VAL          
SEQRES  12 J  570  GLU ASP GLN GLY PHE LEU ASP THR LEU LYS ASP LEU ILE          
SEQRES  13 J  570  SER ASP SER ASN PRO MET VAL VAL ALA ASN ALA VAL ALA          
SEQRES  14 J  570  ALA LEU SER GLU ILE ALA GLU SER HIS PRO SER SER ASN          
SEQRES  15 J  570  LEU LEU ASP LEU ASN PRO GLN SER ILE ASN LYS LEU LEU          
SEQRES  16 J  570  THR ALA LEU ASN GLU CYS THR GLU TRP GLY GLN ILE PHE          
SEQRES  17 J  570  ILE LEU ASP CYS LEU ALA ASN TYR MET PRO LYS ASP ASP          
SEQRES  18 J  570  ARG GLU ALA GLN SER ILE CYS GLU ARG VAL THR PRO ARG          
SEQRES  19 J  570  LEU SER HIS ALA ASN SER ALA VAL VAL LEU SER ALA VAL          
SEQRES  20 J  570  LYS VAL LEU MET LYS PHE MET GLU MET LEU SER LYS ASP          
SEQRES  21 J  570  LEU ASP TYR TYR GLY THR LEU LEU LYS LYS LEU ALA PRO          
SEQRES  22 J  570  PRO LEU VAL THR LEU LEU SER ALA GLU PRO GLU LEU GLN          
SEQRES  23 J  570  TYR VAL ALA LEU ARG ASN ILE ASN LEU ILE VAL GLN LYS          
SEQRES  24 J  570  ARG PRO GLU ILE LEU LYS HIS GLU MET LYS VAL PHE PHE          
SEQRES  25 J  570  VAL LYS TYR ASN ASP PRO ILE TYR VAL LYS LEU GLU LYS          
SEQRES  26 J  570  LEU ASP ILE MET ILE ARG LEU ALA SER GLN ALA ASN ILE          
SEQRES  27 J  570  ALA GLN VAL LEU ALA GLU LEU ARG GLU TYR ALA THR GLU          
SEQRES  28 J  570  VAL ASP VAL ASP PHE VAL ARG LYS ALA VAL ARG ALA ILE          
SEQRES  29 J  570  GLY ARG CYS ALA ILE LYS VAL GLU GLN SER ALA GLU ARG          
SEQRES  30 J  570  CYS VAL SER THR LEU LEU ASP LEU ILE GLN THR LYS VAL          
SEQRES  31 J  570  ASN TYR VAL VAL GLN GLU ALA ILE VAL VAL ILE LYS ASP          
SEQRES  32 J  570  ILE PHE ARG LYS TYR PRO ASN LYS TYR GLU SER VAL ILE          
SEQRES  33 J  570  ALA THR LEU CYS GLU ASN LEU ASP SER LEU ASP GLU PRO          
SEQRES  34 J  570  GLU ALA ARG ALA ALA MET ILE TRP ILE VAL GLY GLU TYR          
SEQRES  35 J  570  ALA GLU ARG ILE ASP ASN ALA ASP GLU LEU LEU GLU SER          
SEQRES  36 J  570  PHE LEU GLU GLY PHE HIS ASP LYS SER THR GLN VAL GLN          
SEQRES  37 J  570  LEU GLN LEU LEU THR ALA ILE VAL LYS LEU PHE LEU LYS          
SEQRES  38 J  570  LYS PRO THR GLU THR GLN GLU LEU VAL GLN GLN VAL LEU          
SEQRES  39 J  570  SER LEU ALA THR GLN ASP SER ASP ASN PRO ASP LEU ARG          
SEQRES  40 J  570  ASP ARG GLY TYR ILE TYR TRP ARG LEU LEU SER THR ASP          
SEQRES  41 J  570  PRO VAL ALA ALA LYS GLU VAL VAL LEU ALA GLU LYS PRO          
SEQRES  42 J  570  LEU ILE SER GLU GLU THR ASP LEU ILE GLU PRO THR LEU          
SEQRES  43 J  570  LEU ASP GLU LEU ILE CYS TYR ILE GLY THR LEU ALA SER          
SEQRES  44 J  570  VAL TYR HIS LYS PRO PRO SER ALA PHE VAL GLU                  
SEQRES   1 L  165  GLU MET ARG ILE LEU MET VAL GLY LEU ASP ALA ALA GLY          
SEQRES   2 L  165  LYS THR THR ILE LEU TYR LYS LEU LYS LEU GLY GLU ILE          
SEQRES   3 L  165  VAL THR THR ILE PRO THR ILE GLY PHE ASN VAL GLU THR          
SEQRES   4 L  165  VAL GLU TYR LYS ASN ILE SER PHE THR VAL TRP ASP VAL          
SEQRES   5 L  165  GLY GLY LEU ASP LYS ILE ARG PRO LEU TRP ARG HIS TYR          
SEQRES   6 L  165  PHE GLN ASN THR GLN GLY LEU ILE PHE VAL VAL ASP SER          
SEQRES   7 L  165  ASN ASP ARG GLU ARG VAL ASN GLU ALA ARG GLU GLU LEU          
SEQRES   8 L  165  MET ARG MET LEU ALA GLU ASP GLU LEU ARG ASP ALA VAL          
SEQRES   9 L  165  LEU LEU VAL PHE ALA ASN LYS GLN ASP LEU PRO ASN ALA          
SEQRES  10 L  165  MET ASN ALA ALA GLU ILE THR ASP LYS LEU GLY LEU HIS          
SEQRES  11 L  165  SER LEU ARG HIS ARG ASN TRP TYR ILE GLN ALA THR CYS          
SEQRES  12 L  165  ALA THR SER GLY ASP GLY LEU TYR GLU GLY LEU ASP TRP          
SEQRES  13 L  165  LEU SER ASN GLN LEU ARG ASN GLN LYS                          
SEQRES   1 R  585  PRO ILE ARG LEU ARG GLU LEU ILE ARG THR ILE ARG THR          
SEQRES   2 R  585  ALA ARG THR GLN ALA GLU GLU ARG GLU MET ILE GLN LYS          
SEQRES   3 R  585  GLU CYS ALA ALA ILE ARG SER SER PHE ARG GLU GLU ASP          
SEQRES   4 R  585  ASN THR TYR ARG CYS ARG ASN VAL ALA LYS LEU LEU TYR          
SEQRES   5 R  585  MET HIS MET LEU GLY TYR PRO ALA HIS PHE GLY GLN LEU          
SEQRES   6 R  585  GLU CYS LEU LYS LEU ILE ALA SER GLN LYS PHE THR ASP          
SEQRES   7 R  585  LYS ARG ILE GLY TYR LEU GLY ALA MET LEU LEU LEU ASP          
SEQRES   8 R  585  GLU ARG GLN ASP VAL HIS LEU LEU MET THR ASN CYS ILE          
SEQRES   9 R  585  LYS ASN ASP LEU ASN HIS SER THR GLN PHE VAL GLN GLY          
SEQRES  10 R  585  LEU ALA LEU CYS THR LEU GLY CYS MET GLY SER SER GLU          
SEQRES  11 R  585  MET CYS ARG ASP LEU ALA GLY GLU VAL GLU LYS LEU LEU          
SEQRES  12 R  585  LYS THR SER ASN SER TYR LEU ARG LYS LYS ALA ALA LEU          
SEQRES  13 R  585  CYS ALA VAL HIS VAL ILE ARG LYS VAL PRO GLU LEU MET          
SEQRES  14 R  585  GLU MET PHE LEU PRO ALA THR LYS ASN LEU LEU ASN GLU          
SEQRES  15 R  585  LYS ASN HIS GLY VAL LEU HIS THR SER VAL VAL LEU LEU          
SEQRES  16 R  585  THR GLU MET CYS GLU ARG SER PRO ASP MET LEU ALA HIS          
SEQRES  17 R  585  PHE ARG LYS LEU VAL PRO GLN LEU VAL ARG ILE LEU LYS          
SEQRES  18 R  585  ASN LEU ILE MET SER GLY TYR SER PRO GLU HIS ASP VAL          
SEQRES  19 R  585  SER GLY ILE SER ASP PRO PHE LEU GLN VAL ARG ILE LEU          
SEQRES  20 R  585  ARG LEU LEU ARG ILE LEU GLY ARG ASN ASP ASP ASP SER          
SEQRES  21 R  585  SER GLU ALA MET ASN ASP ILE LEU ALA GLN VAL ALA THR          
SEQRES  22 R  585  ASN THR GLU THR SER LYS ASN VAL GLY ASN ALA ILE LEU          
SEQRES  23 R  585  TYR GLU THR VAL LEU THR ILE MET ASP ILE LYS SER GLU          
SEQRES  24 R  585  SER GLY LEU ARG VAL LEU ALA ILE ASN ILE LEU GLY ARG          
SEQRES  25 R  585  PHE LEU LEU ASN ASN ASP LYS ASN ILE ARG TYR VAL ALA          
SEQRES  26 R  585  LEU THR SER LEU LEU LYS THR VAL GLN THR ASP HIS ASN          
SEQRES  27 R  585  ALA VAL GLN ARG HIS ARG SER THR ILE VAL ASP CYS LEU          
SEQRES  28 R  585  LYS ASP LEU ASP VAL SER ILE LYS ARG ARG ALA MET GLU          
SEQRES  29 R  585  LEU SER PHE ALA LEU VAL ASN GLY ASN ASN ILE ARG GLY          
SEQRES  30 R  585  MET MET LYS GLU LEU LEU TYR PHE LEU ASP SER CYS GLU          
SEQRES  31 R  585  PRO GLU PHE LYS ALA ASP CYS ALA SER GLY ILE PHE LEU          
SEQRES  32 R  585  ALA ALA GLU LYS TYR ALA PRO SER LYS ARG TRP HIS ILE          
SEQRES  33 R  585  ASP THR ILE MET ARG VAL LEU THR THR ALA GLY SER TYR          
SEQRES  34 R  585  VAL ARG ASP ASP ALA VAL PRO ASN LEU ILE GLN LEU ILE          
SEQRES  35 R  585  THR ASN SER VAL GLU MET HIS ALA TYR THR VAL GLN ARG          
SEQRES  36 R  585  LEU TYR LYS ALA ILE LEU GLY ASP TYR SER GLN GLN PRO          
SEQRES  37 R  585  LEU VAL GLN VAL ALA ALA TRP CYS ILE GLY GLU TYR GLY          
SEQRES  38 R  585  ASP LEU LEU VAL SER GLY GLN CYS GLU GLU GLU GLU PRO          
SEQRES  39 R  585  ILE GLN VAL THR GLU ASP GLU VAL LEU ASP ILE LEU GLU          
SEQRES  40 R  585  SER VAL LEU ILE SER ASN MET SER THR SER VAL THR ARG          
SEQRES  41 R  585  GLY TYR ALA LEU THR ALA ILE MET LYS LEU SER THR ARG          
SEQRES  42 R  585  PHE THR CYS THR VAL ASN ARG ILE LYS LYS VAL VAL SER          
SEQRES  43 R  585  ILE TYR GLY SER SER ILE ASP VAL GLU LEU GLN GLN ARG          
SEQRES  44 R  585  ALA VAL GLU TYR ASN ALA LEU PHE LYS LYS TYR ASP HIS          
SEQRES  45 R  585  MET ARG SER ALA LEU LEU GLU ARG MET PRO VAL MET GLU          
SEQRES   1 V  165  GLU MET ARG ILE LEU MET VAL GLY LEU ASP ALA ALA GLY          
SEQRES   2 V  165  LYS THR THR ILE LEU TYR LYS LEU LYS LEU GLY GLU ILE          
SEQRES   3 V  165  VAL THR THR ILE PRO THR ILE GLY PHE ASN VAL GLU THR          
SEQRES   4 V  165  VAL GLU TYR LYS ASN ILE SER PHE THR VAL TRP ASP VAL          
SEQRES   5 V  165  GLY GLY LEU ASP LYS ILE ARG PRO LEU TRP ARG HIS TYR          
SEQRES   6 V  165  PHE GLN ASN THR GLN GLY LEU ILE PHE VAL VAL ASP SER          
SEQRES   7 V  165  ASN ASP ARG GLU ARG VAL ASN GLU ALA ARG GLU GLU LEU          
SEQRES   8 V  165  MET ARG MET LEU ALA GLU ASP GLU LEU ARG ASP ALA VAL          
SEQRES   9 V  165  LEU LEU VAL PHE ALA ASN LYS GLN ASP LEU PRO ASN ALA          
SEQRES  10 V  165  MET ASN ALA ALA GLU ILE THR ASP LYS LEU GLY LEU HIS          
SEQRES  11 V  165  SER LEU ARG HIS ARG ASN TRP TYR ILE GLN ALA THR CYS          
SEQRES  12 V  165  ALA THR SER GLY ASP GLY LEU TYR GLU GLY LEU ASP TRP          
SEQRES  13 V  165  LEU SER ASN GLN LEU ARG ASN GLN LYS                          
SEQRES   1 X  422  SER ALA SER ALA VAL TYR VAL LEU ASP LEU LYS GLY LYS          
SEQRES   2 X  422  VAL LEU ILE CYS ARG ASN TYR ARG GLY ASP VAL ASP MET          
SEQRES   3 X  422  SER GLU VAL GLU HIS PHE MET PRO ILE LEU MET GLU LYS          
SEQRES   4 X  422  GLU GLU GLU GLY MET LEU SER PRO ILE LEU ALA HIS GLY          
SEQRES   5 X  422  GLY VAL ARG PHE MET TRP ILE LYS HIS ASN ASN LEU TYR          
SEQRES   6 X  422  LEU VAL ALA THR SER LYS LYS ASN ALA CYS VAL SER LEU          
SEQRES   7 X  422  VAL PHE SER PHE LEU TYR LYS VAL VAL GLN VAL PHE SER          
SEQRES   8 X  422  GLU TYR PHE LYS GLU LEU GLU GLU GLU SER ILE ARG ASP          
SEQRES   9 X  422  ASN PHE VAL ILE ILE TYR GLU LEU LEU ASP GLU LEU MET          
SEQRES  10 X  422  ASP PHE GLY TYR PRO GLN THR THR ASP SER LYS ILE LEU          
SEQRES  11 X  422  GLN GLU TYR ILE THR GLN GLU GLY HIS LYS LEU GLU THR          
SEQRES  12 X  422  GLY ALA PRO ARG PRO PRO ALA THR VAL THR ASN ALA VAL          
SEQRES  13 X  422  SER TRP ARG SER GLU GLY ILE LYS TYR ARG LYS ASN GLU          
SEQRES  14 X  422  VAL PHE LEU ASP VAL ILE GLU ALA VAL ASN LEU LEU VAL          
SEQRES  15 X  422  SER ALA ASN GLY ASN VAL LEU ARG SER GLU ILE VAL GLY          
SEQRES  16 X  422  SER ILE LYS MET ARG VAL PHE LEU SER GLY MET PRO GLU          
SEQRES  17 X  422  LEU ARG LEU GLY LEU ASN ASP LYS VAL LEU PHE ASP ASN          
SEQRES  18 X  422  THR GLY ARG GLY LYS SER LYS SER VAL GLU LEU GLU ASP          
SEQRES  19 X  422  VAL LYS PHE HIS GLN CYS VAL ARG LEU SER ARG PHE GLU          
SEQRES  20 X  422  ASN ASP ARG THR ILE SER PHE ILE PRO PRO ASP GLY GLU          
SEQRES  21 X  422  PHE GLU LEU MET SER TYR ARG LEU ASN THR HIS VAL LYS          
SEQRES  22 X  422  PRO LEU ILE TRP ILE GLU SER VAL ILE GLU LYS HIS SER          
SEQRES  23 X  422  HIS SER ARG ILE GLU TYR MET VAL LYS ALA LYS SER GLN          
SEQRES  24 X  422  PHE LYS ARG ARG SER THR ALA ASN ASN VAL GLU ILE HIS          
SEQRES  25 X  422  ILE PRO VAL PRO ASN ASP ALA ASP SER PRO LYS PHE LYS          
SEQRES  26 X  422  THR THR VAL GLY SER VAL LYS TRP VAL PRO GLU ASN SER          
SEQRES  27 X  422  GLU ILE VAL TRP SER VAL LYS SER PHE PRO GLY GLY LYS          
SEQRES  28 X  422  GLU TYR LEU MET ARG ALA HIS PHE GLY LEU PRO SER VAL          
SEQRES  29 X  422  GLU ALA GLU ASP LYS GLU GLY LYS PRO PRO ILE SER VAL          
SEQRES  30 X  422  LYS PHE GLU ILE PRO TYR PHE THR THR SER GLY ILE GLN          
SEQRES  31 X  422  VAL ARG TYR LEU LYS ILE ILE GLU LYS SER GLY TYR GLN          
SEQRES  32 X  422  ALA LEU PRO TRP VAL ARG TYR ILE THR GLN ASN GLY ASP          
SEQRES  33 X  422  TYR GLN LEU ARG THR GLN                                      
SEQRES   1 b  142  MET ILE HIS PHE ILE LEU LEU PHE SER ARG GLN GLY LYS          
SEQRES   2 b  142  LEU ARG LEU GLN LYS TRP TYR ILE THR LEU PRO ASP LYS          
SEQRES   3 b  142  GLU ARG LYS LYS ILE THR ARG GLU ILE VAL GLN ILE ILE          
SEQRES   4 b  142  LEU SER ARG GLY HIS ARG THR SER SER PHE VAL ASP TRP          
SEQRES   5 b  142  LYS GLU LEU LYS LEU VAL TYR LYS ARG TYR ALA SER LEU          
SEQRES   6 b  142  TYR PHE CYS CYS ALA ILE GLU ASN GLN ASP ASN GLU LEU          
SEQRES   7 b  142  LEU THR LEU GLU ILE VAL HIS ARG TYR VAL GLU LEU LEU          
SEQRES   8 b  142  ASP LYS TYR PHE GLY ASN VAL CYS GLU LEU ASP ILE ILE          
SEQRES   9 b  142  PHE ASN PHE GLU LYS ALA TYR PHE ILE LEU ASP GLU PHE          
SEQRES  10 b  142  ILE ILE GLY GLY GLU ILE GLN GLU THR SER LYS LYS ILE          
SEQRES  11 b  142  ALA VAL LYS ALA ILE GLU ASP SER ASP MET LEU GLN              
SEQRES   1 Z  264  MET SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR ASP          
SEQRES   2 Z  264  ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA MET          
SEQRES   3 Z  264  GLY SER ALA SER THR SER TYR ASP TYR CYS ARG VAL PRO          
SEQRES   4 Z  264  MET GLU ASP GLY ASP LYS ARG CYS LYS GLY SER ASP GLU          
SEQRES   5 Z  264  ALA SER GLU GLY SER GLY MET GLY GLY LYS TRP SER LYS          
SEQRES   6 Z  264  SER SER VAL ILE GLY TRP PRO ALA VAL ARG GLU ARG MET          
SEQRES   7 Z  264  ARG ARG ALA GLU PRO ALA ALA ASP GLY VAL GLY ALA VAL          
SEQRES   8 Z  264  SER ARG ASP LEU GLU LYS HIS GLY ALA ILE THR SER SER          
SEQRES   9 Z  264  ASN THR ALA ALA ASN ASN ALA ALA CYS ALA TRP LEU GLU          
SEQRES  10 Z  264  ALA GLN GLU GLU GLU GLU VAL GLY PHE PRO VAL THR PRO          
SEQRES  11 Z  264  GLN VAL PRO LEU ARG PRO MET THR TYR LYS ALA ALA VAL          
SEQRES  12 Z  264  ASP LEU SER HIS PHE LEU LYS GLU LYS GLY GLY LEU GLU          
SEQRES  13 Z  264  GLY LEU ILE HIS SER GLN ARG ARG GLN ASP ILE LEU ASP          
SEQRES  14 Z  264  LEU TRP ILE TYR HIS THR GLN GLY TYR PHE PRO ASP TRP          
SEQRES  15 Z  264  GLN ASN TYR THR PRO GLY PRO GLY VAL ARG TYR PRO LEU          
SEQRES  16 Z  264  THR PHE GLY TRP CYS TYR LYS LEU VAL PRO VAL GLU PRO          
SEQRES  17 Z  264  ASP LYS VAL GLU GLU ALA ASN LYS GLY GLU ASN THR SER          
SEQRES  18 Z  264  LEU LEU HIS PRO VAL SER LEU HIS GLY MET ASP ASP PRO          
SEQRES  19 Z  264  GLU ARG GLU VAL LEU GLU TRP ARG PHE ASP SER ARG LEU          
SEQRES  20 Z  264  ALA PHE HIS HIS VAL ALA ARG GLU LEU HIS PRO GLU TYR          
SEQRES  21 Z  264  PHE LYS ASN CYS                                              
HET    GTP  C1001      32                                                       
HET     MG  C1002       1                                                       
HET    GTP  H1001      32                                                       
HET     MG  H1002       1                                                       
HET    GTP  K1001      32                                                       
HET     MG  K1002       1                                                       
HET    GTP  U1001      32                                                       
HET     MG  U1002       1                                                       
HET    GTP  L1001      32                                                       
HET     MG  L1002       1                                                       
HET    GTP  V1001      32                                                       
HET     MG  V1002       1                                                       
HETNAM     GTP GUANOSINE-5'-TRIPHOSPHATE                                        
HETNAM      MG MAGNESIUM ION                                                    
FORMUL  25  GTP    6(C10 H16 N5 O14 P3)                                         
FORMUL  26   MG    6(MG 2+)                                                     
HELIX    1 AA1 ILE B   15  ASN B   23  1                                   9    
HELIX    2 AA2 LYS B   26  VAL B   43  1                                  18    
HELIX    3 AA3 VAL B   47  ALA B   49  5                                   3    
HELIX    4 AA4 LEU B   50  CYS B   57  1                                   8    
HELIX    5 AA5 ASN B   62  TYR B   76  1                                  15    
HELIX    6 AA6 ASP B   82  MET B   86  5                                   5    
HELIX    7 AA7 ALA B   87  CYS B   95  1                                   9    
HELIX    8 AA8 ASN B   99  ILE B  113  1                                  15    
HELIX    9 AA9 LEU B  122  LYS B  131  1                                  10    
HELIX   10 AB1 ASP B  134  ASN B  152  1                                  19    
HELIX   11 AB2 ASN B  152  GLY B  160  1                                   9    
HELIX   12 AB3 GLY B  160  SER B  170  1                                  11    
HELIX   13 AB4 ASN B  173  HIS B  191  1                                  19    
HELIX   14 AB5 ASN B  200  ASN B  212  1                                  13    
HELIX   15 AB6 THR B  215  LEU B  226  1                                  12    
HELIX   16 AB7 ASP B  233  THR B  245  1                                  13    
HELIX   17 AB8 PRO B  246  HIS B  250  5                                   5    
HELIX   18 AB9 ASN B  252  MET B  267  1                                  16    
HELIX   19 AC1 LEU B  274  LYS B  283  1                                  10    
HELIX   20 AC2 LEU B  284  LEU B  291  1                                   8    
HELIX   21 AC3 LEU B  292  ALA B  294  5                                   3    
HELIX   22 AC4 GLU B  295  ARG B  313  1                                  19    
HELIX   23 AC5 MET B  321  PHE B  325  5                                   5    
HELIX   24 AC6 PRO B  331  LEU B  345  1                                  15    
HELIX   25 AC7 SER B  347  ALA B  349  5                                   3    
HELIX   26 AC8 ASN B  350  GLU B  360  1                                  11    
HELIX   27 AC9 ASP B  366  VAL B  384  1                                  19    
HELIX   28 AD1 SER B  387  GLN B  400  1                                  14    
HELIX   29 AD2 VAL B  403  TYR B  421  1                                  19    
HELIX   30 AD3 VAL B  428  CYS B  433  1                                   6    
HELIX   31 AD4 GLU B  441  TYR B  455  1                                  15    
HELIX   32 AD5 ASN B  461  LEU B  470  1                                  10    
HELIX   33 AD6 GLY B  472  LYS B  476  5                                   5    
HELIX   34 AD7 THR B  478  LYS B  495  1                                  18    
HELIX   35 AD8 THR B  499  THR B  511  1                                  13    
HELIX   36 AD9 ASN B  516  ASP B  533  1                                  18    
HELIX   37 AE1 ASP B  533  VAL B  541  1                                   9    
HELIX   38 AE2 GLU B  556  CYS B  565  1                                  10    
HELIX   39 AE3 THR B  569  HIS B  575  1                                   7    
HELIX   40 AE4 GLY C   29  LEU C   39  1                                  11    
HELIX   41 AE5 LEU C   71  ARG C   79  5                                   9    
HELIX   42 AE6 ASP C   96  LEU C  111  1                                  16    
HELIX   43 AE7 ALA C  137  GLY C  144  1                                   8    
HELIX   44 AE8 GLY C  165  ARG C  178  1                                  14    
HELIX   45 AE9 ARG G    6  THR G   16  1                                  11    
HELIX   46 AF1 THR G   19  GLU G   40  1                                  22    
HELIX   47 AF2 TYR G   45  LEU G   59  1                                  15    
HELIX   48 AF3 ALA G   63  PHE G   65  5                                   3    
HELIX   49 AF4 GLY G   66  ALA G   75  1                                  10    
HELIX   50 AF5 LYS G   78  LEU G   93  1                                  16    
HELIX   51 AF6 ASP G   94  ASP G   98  5                                   5    
HELIX   52 AF7 VAL G   99  LEU G  101  5                                   3    
HELIX   53 AF8 LEU G  102  LEU G  111  1                                  10    
HELIX   54 AF9 THR G  115  GLY G  130  1                                  16    
HELIX   55 AG1 SER G  131  LEU G  138  1                                   8    
HELIX   56 AG2 LEU G  138  LEU G  145  1                                   8    
HELIX   57 AG3 ASN G  150  VAL G  168  1                                  19    
HELIX   58 AG4 PRO G  169  PHE G  175  5                                   7    
HELIX   59 AG5 ASN G  187  SER G  205  1                                  19    
HELIX   60 AG6 MET G  208  ARG G  213  1                                   6    
HELIX   61 AG7 LEU G  215  SER G  229  1                                  15    
HELIX   62 AG8 ASP G  242  LEU G  256  1                                  15    
HELIX   63 AG9 ASP G  261  MET G  267  1                                   7    
HELIX   64 AH1 MET G  267  ALA G  275  1                                   9    
HELIX   65 AH2 LYS G  282  ILE G  299  1                                  18    
HELIX   66 AH3 GLU G  302  ASN G  319  1                                  18    
HELIX   67 AH4 ASP G  321  THR G  335  1                                  15    
HELIX   68 AH5 ASP G  339  ARG G  345  1                                   7    
HELIX   69 AH6 HIS G  346  LYS G  355  1                                  10    
HELIX   70 AH7 ASP G  358  VAL G  373  1                                  16    
HELIX   71 AH8 ASN G  377  SER G  391  1                                  15    
HELIX   72 AH9 GLU G  393  ALA G  412  1                                  20    
HELIX   73 AI1 LYS G  415  ALA G  429  1                                  15    
HELIX   74 AI2 ASP G  436  SER G  448  1                                  13    
HELIX   75 AI3 HIS G  452  LEU G  464  1                                  13    
HELIX   76 AI4 GLN G  469  TYR G  483  1                                  15    
HELIX   77 AI5 TYR G  483  VAL G  488  1                                   6    
HELIX   78 AI6 ASP G  503  SER G  515  1                                  13    
HELIX   79 AI7 VAL G  521  LEU G  533  1                                  13    
HELIX   80 AI8 ARG G  543  TYR G  551  1                                   9    
HELIX   81 AI9 GLY G  552  SER G  554  5                                   3    
HELIX   82 AJ1 ASP G  556  LYS G  572  1                                  17    
HELIX   83 AJ2 ARG G  577  LEU G  581  5                                   5    
HELIX   84 AJ3 GLY H   29  LYS H   38  1                                  10    
HELIX   85 AJ4 ILE H   74  PHE H   82  5                                   9    
HELIX   86 AJ5 ARG H   99  ALA H  112  1                                  14    
HELIX   87 AJ6 ASN H  135  GLY H  144  1                                  10    
HELIX   88 AJ7 LEU H  145  LEU H  148  5                                   4    
HELIX   89 AJ8 GLY H  165  GLN H  176  1                                  12    
HELIX   90 AJ9 ASP M   26  SER M   28  5                                   3    
HELIX   91 AK1 GLU M   29  GLU M   43  1                                  15    
HELIX   92 AK2 CYS M   76  PHE M   95  1                                  20    
HELIX   93 AK3 GLU M   99  ASP M  105  1                                   7    
HELIX   94 AK4 ASN M  106  LEU M  117  1                                  12    
HELIX   95 AK5 ASP M  127  GLN M  132  1                                   6    
HELIX   96 AK6 PRO M  150  ASN M  155  1                                   6    
HELIX   97 AK7 ASP M  216  GLY M  224  1                                   9    
HELIX   98 AK8 ARG M  243  ARG M  251  1                                   9    
HELIX   99 AK9 PRO S   24  SER S   41  1                                  18    
HELIX  100 AL1 GLU S   77  PHE S   95  1                                  19    
HELIX  101 AL2 CYS S   99  ASN S  106  1                                   8    
HELIX  102 AL3 ASN S  106  PHE S  117  1                                  12    
HELIX  103 AL4 LYS S  128  GLN S  142  1                                  15    
HELIX  104 AL5 PRO N   14  ALA N   23  1                                  10    
HELIX  105 AL6 THR N   80  GLY N   95  1                                  16    
HELIX  106 AL7 SER N  103  GLN N  118  1                                  16    
HELIX  107 AL8 SER N  187  ALA N  190  5                                   4    
HELIX  108 AL9 HIS N  193  HIS N  199  1                                   7    
HELIX  109 AM1 ILE I   15  ASN I   23  1                                   9    
HELIX  110 AM2 LYS I   26  VAL I   43  1                                  18    
HELIX  111 AM3 VAL I   47  ALA I   49  5                                   3    
HELIX  112 AM4 LEU I   50  CYS I   57  1                                   8    
HELIX  113 AM5 ASN I   62  TYR I   76  1                                  15    
HELIX  114 AM6 ASP I   82  MET I   86  5                                   5    
HELIX  115 AM7 ALA I   87  CYS I   95  1                                   9    
HELIX  116 AM8 ASN I   99  ILE I  113  1                                  15    
HELIX  117 AM9 LEU I  122  LYS I  131  1                                  10    
HELIX  118 AN1 ASP I  134  ASN I  152  1                                  19    
HELIX  119 AN2 ASN I  152  GLY I  160  1                                   9    
HELIX  120 AN3 GLY I  160  SER I  170  1                                  11    
HELIX  121 AN4 ASN I  173  HIS I  191  1                                  19    
HELIX  122 AN5 ASN I  200  ASN I  212  1                                  13    
HELIX  123 AN6 THR I  215  LEU I  226  1                                  12    
HELIX  124 AN7 ASP I  233  THR I  245  1                                  13    
HELIX  125 AN8 PRO I  246  HIS I  250  5                                   5    
HELIX  126 AN9 ASN I  252  MET I  267  1                                  16    
HELIX  127 AO1 LEU I  274  LYS I  283  1                                  10    
HELIX  128 AO2 LEU I  284  LEU I  291  1                                   8    
HELIX  129 AO3 LEU I  292  ALA I  294  5                                   3    
HELIX  130 AO4 GLU I  295  ARG I  313  1                                  19    
HELIX  131 AO5 MET I  321  PHE I  325  5                                   5    
HELIX  132 AO6 PRO I  331  LEU I  345  1                                  15    
HELIX  133 AO7 SER I  347  ALA I  349  5                                   3    
HELIX  134 AO8 ASN I  350  GLU I  360  1                                  11    
HELIX  135 AO9 ASP I  366  VAL I  384  1                                  19    
HELIX  136 AP1 SER I  387  GLN I  400  1                                  14    
HELIX  137 AP2 VAL I  403  TYR I  421  1                                  19    
HELIX  138 AP3 VAL I  428  CYS I  433  1                                   6    
HELIX  139 AP4 GLU I  441  TYR I  455  1                                  15    
HELIX  140 AP5 ASN I  461  LEU I  470  1                                  10    
HELIX  141 AP6 GLY I  472  LYS I  476  5                                   5    
HELIX  142 AP7 THR I  478  LYS I  495  1                                  18    
HELIX  143 AP8 THR I  499  THR I  511  1                                  13    
HELIX  144 AP9 ASN I  516  ASP I  533  1                                  18    
HELIX  145 AQ1 ASP I  533  VAL I  541  1                                   9    
HELIX  146 AQ2 GLU I  556  CYS I  565  1                                  10    
HELIX  147 AQ3 THR I  569  HIS I  575  1                                   7    
HELIX  148 AQ4 GLY K   29  LEU K   39  1                                  11    
HELIX  149 AQ5 LEU K   71  ARG K   79  5                                   9    
HELIX  150 AQ6 ASP K   96  LEU K  111  1                                  16    
HELIX  151 AQ7 ALA K  137  GLY K  144  1                                   8    
HELIX  152 AQ8 GLY K  165  ARG K  178  1                                  14    
HELIX  153 AQ9 ARG Q    6  THR Q   16  1                                  11    
HELIX  154 AR1 THR Q   19  GLU Q   40  1                                  22    
HELIX  155 AR2 TYR Q   45  LEU Q   59  1                                  15    
HELIX  156 AR3 ALA Q   63  PHE Q   65  5                                   3    
HELIX  157 AR4 GLY Q   66  ALA Q   75  1                                  10    
HELIX  158 AR5 LYS Q   78  LEU Q   93  1                                  16    
HELIX  159 AR6 ASP Q   94  ASP Q   98  5                                   5    
HELIX  160 AR7 VAL Q   99  LEU Q  101  5                                   3    
HELIX  161 AR8 LEU Q  102  LEU Q  111  1                                  10    
HELIX  162 AR9 THR Q  115  GLY Q  130  1                                  16    
HELIX  163 AS1 SER Q  131  LEU Q  138  1                                   8    
HELIX  164 AS2 LEU Q  138  LEU Q  145  1                                   8    
HELIX  165 AS3 ASN Q  150  VAL Q  168  1                                  19    
HELIX  166 AS4 PRO Q  169  PHE Q  175  5                                   7    
HELIX  167 AS5 ASN Q  187  SER Q  205  1                                  19    
HELIX  168 AS6 MET Q  208  ARG Q  213  1                                   6    
HELIX  169 AS7 LEU Q  215  SER Q  229  1                                  15    
HELIX  170 AS8 ASP Q  242  LEU Q  256  1                                  15    
HELIX  171 AS9 ASP Q  261  MET Q  267  1                                   7    
HELIX  172 AT1 MET Q  267  ALA Q  275  1                                   9    
HELIX  173 AT2 LYS Q  282  ILE Q  299  1                                  18    
HELIX  174 AT3 GLU Q  302  ASN Q  319  1                                  18    
HELIX  175 AT4 ASP Q  321  THR Q  335  1                                  15    
HELIX  176 AT5 ASP Q  339  ARG Q  345  1                                   7    
HELIX  177 AT6 HIS Q  346  LYS Q  355  1                                  10    
HELIX  178 AT7 ASP Q  358  VAL Q  373  1                                  16    
HELIX  179 AT8 ASN Q  377  SER Q  391  1                                  15    
HELIX  180 AT9 GLU Q  393  ALA Q  412  1                                  20    
HELIX  181 AU1 LYS Q  415  ALA Q  429  1                                  15    
HELIX  182 AU2 ASP Q  436  SER Q  448  1                                  13    
HELIX  183 AU3 HIS Q  452  LEU Q  464  1                                  13    
HELIX  184 AU4 GLN Q  469  TYR Q  483  1                                  15    
HELIX  185 AU5 TYR Q  483  VAL Q  488  1                                   6    
HELIX  186 AU6 ASP Q  503  SER Q  515  1                                  13    
HELIX  187 AU7 VAL Q  521  LEU Q  533  1                                  13    
HELIX  188 AU8 ARG Q  543  TYR Q  551  1                                   9    
HELIX  189 AU9 GLY Q  552  SER Q  554  5                                   3    
HELIX  190 AV1 ASP Q  556  LYS Q  572  1                                  17    
HELIX  191 AV2 ARG Q  577  LEU Q  581  5                                   5    
HELIX  192 AV3 GLY U   29  LYS U   38  1                                  10    
HELIX  193 AV4 ILE U   74  PHE U   82  5                                   9    
HELIX  194 AV5 ARG U   99  ALA U  112  1                                  14    
HELIX  195 AV6 ASN U  135  GLY U  144  1                                  10    
HELIX  196 AV7 LEU U  145  LEU U  148  5                                   4    
HELIX  197 AV8 CYS U  159  GLY U  163  5                                   5    
HELIX  198 AV9 GLY U  165  GLN U  176  1                                  12    
HELIX  199 AW1 ASP W   26  SER W   28  5                                   3    
HELIX  200 AW2 GLU W   29  GLU W   43  1                                  15    
HELIX  201 AW3 CYS W   76  PHE W   95  1                                  20    
HELIX  202 AW4 GLU W   99  ASP W  105  1                                   7    
HELIX  203 AW5 ASN W  106  LEU W  117  1                                  12    
HELIX  204 AW6 ASP W  127  GLN W  132  1                                   6    
HELIX  205 AW7 PRO W  150  ASN W  155  1                                   6    
HELIX  206 AW8 ASP W  216  GLY W  224  1                                   9    
HELIX  207 AW9 ARG W  243  ARG W  251  1                                   9    
HELIX  208 AX1 PRO a   24  SER a   41  1                                  18    
HELIX  209 AX2 GLU a   77  PHE a   95  1                                  19    
HELIX  210 AX3 CYS a   99  ASN a  106  1                                   8    
HELIX  211 AX4 ASN a  106  PHE a  117  1                                  12    
HELIX  212 AX5 LYS a  128  GLN a  142  1                                  15    
HELIX  213 AX6 PRO Y   14  ALA Y   23  1                                  10    
HELIX  214 AX7 THR Y   80  GLY Y   95  1                                  16    
HELIX  215 AX8 SER Y  103  GLN Y  118  1                                  16    
HELIX  216 AX9 SER Y  187  ALA Y  190  5                                   4    
HELIX  217 AY1 HIS Y  193  HIS Y  199  1                                   7    
HELIX  218 AY2 ILE J   15  ASN J   23  1                                   9    
HELIX  219 AY3 LYS J   26  VAL J   43  1                                  18    
HELIX  220 AY4 VAL J   47  ALA J   49  5                                   3    
HELIX  221 AY5 LEU J   50  CYS J   57  1                                   8    
HELIX  222 AY6 ASN J   62  TYR J   76  1                                  15    
HELIX  223 AY7 ASP J   82  MET J   86  5                                   5    
HELIX  224 AY8 ALA J   87  CYS J   95  1                                   9    
HELIX  225 AY9 ASN J   99  ILE J  113  1                                  15    
HELIX  226 AZ1 LEU J  122  LYS J  131  1                                  10    
HELIX  227 AZ2 ASP J  134  ASN J  152  1                                  19    
HELIX  228 AZ3 ASN J  152  GLY J  160  1                                   9    
HELIX  229 AZ4 GLY J  160  SER J  170  1                                  11    
HELIX  230 AZ5 ASN J  173  HIS J  191  1                                  19    
HELIX  231 AZ6 ASN J  200  ASN J  212  1                                  13    
HELIX  232 AZ7 THR J  215  LEU J  226  1                                  12    
HELIX  233 AZ8 ASP J  233  THR J  245  1                                  13    
HELIX  234 AZ9 PRO J  246  HIS J  250  5                                   5    
HELIX  235 BA1 ASN J  252  MET J  267  1                                  16    
HELIX  236 BA2 LEU J  274  LYS J  283  1                                  10    
HELIX  237 BA3 LEU J  284  LEU J  291  1                                   8    
HELIX  238 BA4 LEU J  292  ALA J  294  5                                   3    
HELIX  239 BA5 GLU J  295  ARG J  313  1                                  19    
HELIX  240 BA6 MET J  321  PHE J  325  5                                   5    
HELIX  241 BA7 PRO J  331  LEU J  345  1                                  15    
HELIX  242 BA8 SER J  347  ALA J  349  5                                   3    
HELIX  243 BA9 ASN J  350  GLU J  360  1                                  11    
HELIX  244 BB1 ASP J  366  VAL J  384  1                                  19    
HELIX  245 BB2 SER J  387  GLN J  400  1                                  14    
HELIX  246 BB3 VAL J  403  TYR J  421  1                                  19    
HELIX  247 BB4 VAL J  428  CYS J  433  1                                   6    
HELIX  248 BB5 GLU J  441  TYR J  455  1                                  15    
HELIX  249 BB6 ASN J  461  LEU J  470  1                                  10    
HELIX  250 BB7 GLY J  472  LYS J  476  5                                   5    
HELIX  251 BB8 THR J  478  LYS J  495  1                                  18    
HELIX  252 BB9 THR J  499  THR J  511  1                                  13    
HELIX  253 BC1 ASN J  516  ASP J  533  1                                  18    
HELIX  254 BC2 ASP J  533  VAL J  541  1                                   9    
HELIX  255 BC3 GLU J  556  CYS J  565  1                                  10    
HELIX  256 BC4 THR J  569  HIS J  575  1                                   7    
HELIX  257 BC5 THR L   31  LEU L   39  1                                   9    
HELIX  258 BC6 LEU L   71  ARG L   79  5                                   9    
HELIX  259 BC7 ASP L   96  LEU L  111  1                                  16    
HELIX  260 BC8 ALA L  137  GLY L  144  1                                   8    
HELIX  261 BC9 GLY L  165  ARG L  178  1                                  14    
HELIX  262 BD1 ARG R    6  THR R   16  1                                  11    
HELIX  263 BD2 THR R   19  GLU R   40  1                                  22    
HELIX  264 BD3 TYR R   45  LEU R   59  1                                  15    
HELIX  265 BD4 ALA R   63  PHE R   65  5                                   3    
HELIX  266 BD5 GLY R   66  ALA R   75  1                                  10    
HELIX  267 BD6 LYS R   78  LEU R   93  1                                  16    
HELIX  268 BD7 ASP R   94  ASP R   98  5                                   5    
HELIX  269 BD8 VAL R   99  LEU R  101  5                                   3    
HELIX  270 BD9 LEU R  102  LEU R  111  1                                  10    
HELIX  271 BE1 THR R  115  GLY R  130  1                                  16    
HELIX  272 BE2 SER R  131  LEU R  138  1                                   8    
HELIX  273 BE3 LEU R  138  LEU R  145  1                                   8    
HELIX  274 BE4 ASN R  150  VAL R  168  1                                  19    
HELIX  275 BE5 PRO R  169  PHE R  175  5                                   7    
HELIX  276 BE6 ASN R  187  SER R  205  1                                  19    
HELIX  277 BE7 MET R  208  ARG R  213  1                                   6    
HELIX  278 BE8 LEU R  215  SER R  229  1                                  15    
HELIX  279 BE9 ASP R  242  LEU R  256  1                                  15    
HELIX  280 BF1 ASP R  261  MET R  267  1                                   7    
HELIX  281 BF2 MET R  267  ALA R  275  1                                   9    
HELIX  282 BF3 LYS R  282  ILE R  299  1                                  18    
HELIX  283 BF4 GLU R  302  ASN R  319  1                                  18    
HELIX  284 BF5 ASP R  321  THR R  335  1                                  15    
HELIX  285 BF6 ASP R  339  ARG R  345  1                                   7    
HELIX  286 BF7 HIS R  346  LYS R  355  1                                  10    
HELIX  287 BF8 ASP R  358  VAL R  373  1                                  16    
HELIX  288 BF9 ASN R  377  SER R  391  1                                  15    
HELIX  289 BG1 GLU R  393  ALA R  412  1                                  20    
HELIX  290 BG2 LYS R  415  ALA R  429  1                                  15    
HELIX  291 BG3 ASP R  436  SER R  448  1                                  13    
HELIX  292 BG4 HIS R  452  LEU R  464  1                                  13    
HELIX  293 BG5 GLN R  469  TYR R  483  1                                  15    
HELIX  294 BG6 TYR R  483  VAL R  488  1                                   6    
HELIX  295 BG7 ASP R  503  SER R  515  1                                  13    
HELIX  296 BG8 VAL R  521  LEU R  533  1                                  13    
HELIX  297 BG9 ARG R  543  TYR R  551  1                                   9    
HELIX  298 BH1 GLY R  552  SER R  554  5                                   3    
HELIX  299 BH2 ASP R  556  LYS R  572  1                                  17    
HELIX  300 BH3 ARG R  577  LEU R  581  5                                   5    
HELIX  301 BH4 GLY V   29  LYS V   38  1                                  10    
HELIX  302 BH5 ILE V   74  PHE V   82  5                                   9    
HELIX  303 BH6 ARG V   99  ALA V  112  1                                  14    
HELIX  304 BH7 ASN V  135  GLY V  144  1                                  10    
HELIX  305 BH8 LEU V  145  LEU V  148  5                                   4    
HELIX  306 BH9 GLY V  165  GLN V  176  1                                  12    
HELIX  307 BI1 ASP X   26  SER X   28  5                                   3    
HELIX  308 BI2 GLU X   29  GLU X   43  1                                  15    
HELIX  309 BI3 CYS X   76  PHE X   95  1                                  20    
HELIX  310 BI4 GLU X   99  ASP X  105  1                                   7    
HELIX  311 BI5 ASN X  106  LEU X  117  1                                  12    
HELIX  312 BI6 ASP X  127  GLN X  132  1                                   6    
HELIX  313 BI7 PRO X  150  ASN X  155  1                                   6    
HELIX  314 BI8 ASP X  216  GLY X  224  1                                   9    
HELIX  315 BI9 ARG X  243  ARG X  251  1                                   9    
HELIX  316 BJ1 PRO b   24  SER b   41  1                                  18    
HELIX  317 BJ2 GLU b   77  PHE b   95  1                                  19    
HELIX  318 BJ3 CYS b   99  ASN b  106  1                                   8    
HELIX  319 BJ4 ASN b  106  PHE b  117  1                                  12    
HELIX  320 BJ5 LYS b  128  GLN b  142  1                                  15    
HELIX  321 BJ6 PRO Z   14  ALA Z   23  1                                  10    
HELIX  322 BJ7 THR Z   80  GLY Z   95  1                                  16    
HELIX  323 BJ8 SER Z  103  GLN Z  118  1                                  16    
HELIX  324 BJ9 SER Z  187  ALA Z  190  5                                   4    
HELIX  325 BK1 HIS Z  193  HIS Z  199  1                                   7    
SHEET    1 AA1 3 ARG C  19  MET C  22  0                                        
SHEET    2 AA1 3 ILE C  61  VAL C  68  1  O  TRP C  66   N  MET C  22           
SHEET    3 AA1 3 PHE C  51  TYR C  58 -1  N  VAL C  56   O  PHE C  63           
SHEET    1 AA2 3 PHE C  90  VAL C  91  0                                        
SHEET    2 AA2 3 VAL C 123  ALA C 125  1  O  PHE C 124   N  PHE C  90           
SHEET    3 AA2 3 ILE C 155  ALA C 157  1  O  GLN C 156   N  ALA C 125           
SHEET    1 AA3 2 ASP G 236  VAL G 237  0                                        
SHEET    2 AA3 2 ILE G 240  SER G 241 -1  O  ILE G 240   N  VAL G 237           
SHEET    1 AA4 6 PHE H  51  TYR H  58  0                                        
SHEET    2 AA4 6 ILE H  61  VAL H  68 -1  O  PHE H  63   N  VAL H  56           
SHEET    3 AA4 6 MET H  18  GLY H  24  1  N  ILE H  20   O  TRP H  66           
SHEET    4 AA4 6 GLY H  87  ASP H  93  1  O  VAL H  91   N  VAL H  23           
SHEET    5 AA4 6 VAL H 120  ASN H 126  1  O  VAL H 120   N  LEU H  88           
SHEET    6 AA4 6 TRP H 153  GLN H 156  1  O  GLN H 156   N  VAL H 123           
SHEET    1 AA5 5 VAL M  15  ASN M  20  0                                        
SHEET    2 AA5 5 ALA M   5  LEU M   9 -1  N  VAL M   8   O  LEU M  16           
SHEET    3 AA5 5 TYR M  66  SER M  71 -1  O  VAL M  68   N  TYR M   7           
SHEET    4 AA5 5 VAL M  55  LYS M  61 -1  N  ARG M  56   O  SER M  71           
SHEET    5 AA5 5 ILE M  49  HIS M  52 -1  N  LEU M  50   O  PHE M  57           
SHEET    1 AA6 2 MET M 118  ASP M 119  0                                        
SHEET    2 AA6 2 TYR M 122  PRO M 123 -1  O  TYR M 122   N  ASP M 119           
SHEET    1 AA7 6 ASP M 235  PHE M 238  0                                        
SHEET    2 AA7 6 GLY M 260  ASN M 270 -1  O  ARG M 268   N  ASP M 235           
SHEET    3 AA7 6 GLU M 193  PHE M 203 -1  N  MET M 200   O  PHE M 262           
SHEET    4 AA7 6 GLU M 170  VAL M 183 -1  N  PHE M 172   O  ARG M 201           
SHEET    5 AA7 6 LEU M 406  LEU M 420  1  O  ASP M 417   N  LEU M 181           
SHEET    6 AA7 6 ILE M 376  SER M 377 -1  N  ILE M 376   O  LEU M 420           
SHEET    1 AA8 6 ASP M 235  PHE M 238  0                                        
SHEET    2 AA8 6 GLY M 260  ASN M 270 -1  O  ARG M 268   N  ASP M 235           
SHEET    3 AA8 6 GLU M 193  PHE M 203 -1  N  MET M 200   O  PHE M 262           
SHEET    4 AA8 6 GLU M 170  VAL M 183 -1  N  PHE M 172   O  ARG M 201           
SHEET    5 AA8 6 LEU M 406  LEU M 420  1  O  ASP M 417   N  LEU M 181           
SHEET    6 AA8 6 GLU M 381  PRO M 383 -1  N  ILE M 382   O  THR M 413           
SHEET    1 AA9 3 ILE M 253  PHE M 255  0                                        
SHEET    2 AA9 3 LEU M 210  LEU M 214 -1  N  LEU M 212   O  ILE M 253           
SHEET    3 AA9 3 VAL M 392  LYS M 396 -1  O  LYS M 396   N  ARG M 211           
SHEET    1 AB1 4 ILE M 277  GLU M 280  0                                        
SHEET    2 AB1 4 ARG M 290  SER M 299 -1  O  LYS M 296   N  GLU M 280           
SHEET    3 AB1 4 GLU M 353  GLY M 361 -1  O  ALA M 358   N  TYR M 293           
SHEET    4 AB1 4 ASP M 321  THR M 327 -1  N  ASP M 321   O  GLY M 361           
SHEET    1 AB2 3 THR M 306  PRO M 315  0                                        
SHEET    2 AB2 3 GLU M 340  PRO M 349 -1  O  PHE M 348   N  ALA M 307           
SHEET    3 AB2 3 SER M 331  VAL M 335 -1  N  VAL M 335   O  GLU M 340           
SHEET    1 AB3 5 LEU S  14  TRP S  19  0                                        
SHEET    2 AB3 5 PHE S   4  PHE S   8 -1  N  LEU S   7   O  ARG S  15           
SHEET    3 AB3 5 TYR S  66  ILE S  71 -1  O  TYR S  66   N  PHE S   8           
SHEET    4 AB3 5 LEU S  55  TYR S  59 -1  N  VAL S  58   O  CYS S  69           
SHEET    5 AB3 5 PHE S  49  TRP S  52 -1  N  VAL S  50   O  LEU S  57           
SHEET    1 AB4 2 ILE S 118  ILE S 119  0                                        
SHEET    2 AB4 2 GLU S 122  ILE S 123 -1  O  GLU S 122   N  ILE S 119           
SHEET    1 AB5 3 ILE N 101  HIS N 102  0                                        
SHEET    2 AB5 3 LEU N 181  PHE N 185 -1  O  LEU N 181   N  HIS N 102           
SHEET    3 AB5 3 TYR N 143  PRO N 147 -1  N  LYS N 144   O  ARG N 184           
SHEET    1 AB6 6 PHE K  51  TYR K  58  0                                        
SHEET    2 AB6 6 ILE K  61  VAL K  68 -1  O  PHE K  63   N  VAL K  56           
SHEET    3 AB6 6 ARG K  19  GLY K  24  1  N  MET K  22   O  TRP K  66           
SHEET    4 AB6 6 PHE K  90  VAL K  91  1  O  VAL K  91   N  VAL K  23           
SHEET    5 AB6 6 VAL K 123  ALA K 125  1  O  PHE K 124   N  PHE K  90           
SHEET    6 AB6 6 ILE K 155  ALA K 157  1  O  GLN K 156   N  ALA K 125           
SHEET    1 AB7 2 ASP Q 236  VAL Q 237  0                                        
SHEET    2 AB7 2 ILE Q 240  SER Q 241 -1  O  ILE Q 240   N  VAL Q 237           
SHEET    1 AB8 6 PHE U  51  TYR U  58  0                                        
SHEET    2 AB8 6 ILE U  61  VAL U  68 -1  O  ASP U  67   N  ASN U  52           
SHEET    3 AB8 6 MET U  18  GLY U  24  1  N  ILE U  20   O  TRP U  66           
SHEET    4 AB8 6 GLY U  87  ASP U  93  1  O  ILE U  89   N  VAL U  23           
SHEET    5 AB8 6 LEU U 121  ASN U 126  1  O  PHE U 124   N  VAL U  92           
SHEET    6 AB8 6 TRP U 153  GLN U 156  1  O  GLN U 156   N  VAL U 123           
SHEET    1 AB9 5 VAL W  15  ASN W  20  0                                        
SHEET    2 AB9 5 ALA W   5  LEU W   9 -1  N  VAL W   8   O  LEU W  16           
SHEET    3 AB9 5 TYR W  66  SER W  71 -1  O  VAL W  68   N  TYR W   7           
SHEET    4 AB9 5 VAL W  55  LYS W  61 -1  N  ARG W  56   O  SER W  71           
SHEET    5 AB9 5 ILE W  49  HIS W  52 -1  N  LEU W  50   O  PHE W  57           
SHEET    1 AC1 2 MET W 118  ASP W 119  0                                        
SHEET    2 AC1 2 TYR W 122  PRO W 123 -1  O  TYR W 122   N  ASP W 119           
SHEET    1 AC2 6 ASP W 235  PHE W 238  0                                        
SHEET    2 AC2 6 GLY W 260  ASN W 270 -1  O  ARG W 268   N  ASP W 235           
SHEET    3 AC2 6 GLU W 193  PHE W 203 -1  N  MET W 200   O  PHE W 262           
SHEET    4 AC2 6 GLU W 170  VAL W 183 -1  N  PHE W 172   O  ARG W 201           
SHEET    5 AC2 6 LEU W 406  LEU W 420  1  O  ASP W 417   N  LEU W 181           
SHEET    6 AC2 6 ILE W 376  SER W 377 -1  N  ILE W 376   O  LEU W 420           
SHEET    1 AC3 6 ASP W 235  PHE W 238  0                                        
SHEET    2 AC3 6 GLY W 260  ASN W 270 -1  O  ARG W 268   N  ASP W 235           
SHEET    3 AC3 6 GLU W 193  PHE W 203 -1  N  MET W 200   O  PHE W 262           
SHEET    4 AC3 6 GLU W 170  VAL W 183 -1  N  PHE W 172   O  ARG W 201           
SHEET    5 AC3 6 LEU W 406  LEU W 420  1  O  ASP W 417   N  LEU W 181           
SHEET    6 AC3 6 GLU W 381  PRO W 383 -1  N  ILE W 382   O  THR W 413           
SHEET    1 AC4 3 ILE W 253  PHE W 255  0                                        
SHEET    2 AC4 3 LEU W 210  LEU W 214 -1  N  LEU W 212   O  ILE W 253           
SHEET    3 AC4 3 VAL W 392  LYS W 396 -1  O  LYS W 396   N  ARG W 211           
SHEET    1 AC5 4 ILE W 277  GLU W 280  0                                        
SHEET    2 AC5 4 ARG W 290  SER W 299 -1  O  LYS W 296   N  GLU W 280           
SHEET    3 AC5 4 GLU W 353  GLY W 361 -1  O  ALA W 358   N  TYR W 293           
SHEET    4 AC5 4 ASP W 321  THR W 327 -1  N  ASP W 321   O  GLY W 361           
SHEET    1 AC6 3 THR W 306  PRO W 315  0                                        
SHEET    2 AC6 3 GLU W 340  PRO W 349 -1  O  PHE W 348   N  ALA W 307           
SHEET    3 AC6 3 SER W 331  VAL W 335 -1  N  VAL W 335   O  GLU W 340           
SHEET    1 AC7 2 PHE W 385  THR W 386  0                                        
SHEET    2 AC7 2 PHE Y  68  PRO Y  69 -1  O  PHE Y  68   N  THR W 386           
SHEET    1 AC8 5 LEU a  14  TRP a  19  0                                        
SHEET    2 AC8 5 PHE a   4  PHE a   8 -1  N  LEU a   7   O  ARG a  15           
SHEET    3 AC8 5 TYR a  66  ILE a  71 -1  O  TYR a  66   N  PHE a   8           
SHEET    4 AC8 5 LEU a  55  TYR a  59 -1  N  VAL a  58   O  CYS a  69           
SHEET    5 AC8 5 PHE a  49  TRP a  52 -1  N  VAL a  50   O  LEU a  57           
SHEET    1 AC9 2 ILE a 118  ILE a 119  0                                        
SHEET    2 AC9 2 GLU a 122  ILE a 123 -1  O  GLU a 122   N  ILE a 119           
SHEET    1 AD1 3 ILE Y 101  HIS Y 102  0                                        
SHEET    2 AD1 3 LEU Y 181  PHE Y 185 -1  O  LEU Y 181   N  HIS Y 102           
SHEET    3 AD1 3 TYR Y 143  PRO Y 147 -1  N  LYS Y 144   O  ARG Y 184           
SHEET    1 AD2 6 PHE L  51  TYR L  58  0                                        
SHEET    2 AD2 6 ILE L  61  VAL L  68 -1  O  PHE L  63   N  VAL L  56           
SHEET    3 AD2 6 ARG L  19  GLY L  24  1  N  ILE L  20   O  THR L  64           
SHEET    4 AD2 6 PHE L  90  VAL L  91  1  O  VAL L  91   N  VAL L  23           
SHEET    5 AD2 6 VAL L 123  ALA L 125  1  O  PHE L 124   N  PHE L  90           
SHEET    6 AD2 6 ILE L 155  ALA L 157  1  O  GLN L 156   N  ALA L 125           
SHEET    1 AD3 2 ASP R 236  VAL R 237  0                                        
SHEET    2 AD3 2 ILE R 240  SER R 241 -1  O  ILE R 240   N  VAL R 237           
SHEET    1 AD4 6 PHE V  51  TYR V  58  0                                        
SHEET    2 AD4 6 ILE V  61  VAL V  68 -1  O  PHE V  63   N  VAL V  56           
SHEET    3 AD4 6 MET V  18  GLY V  24  1  N  ILE V  20   O  TRP V  66           
SHEET    4 AD4 6 GLY V  87  ASP V  93  1  O  ILE V  89   N  LEU V  21           
SHEET    5 AD4 6 VAL V 120  ASN V 126  1  O  VAL V 120   N  LEU V  88           
SHEET    6 AD4 6 TRP V 153  GLN V 156  1  O  GLN V 156   N  VAL V 123           
SHEET    1 AD5 5 VAL X  15  ASN X  20  0                                        
SHEET    2 AD5 5 ALA X   5  LEU X   9 -1  N  VAL X   8   O  LEU X  16           
SHEET    3 AD5 5 TYR X  66  SER X  71 -1  O  VAL X  68   N  TYR X   7           
SHEET    4 AD5 5 VAL X  55  LYS X  61 -1  N  ARG X  56   O  SER X  71           
SHEET    5 AD5 5 ILE X  49  HIS X  52 -1  N  LEU X  50   O  PHE X  57           
SHEET    1 AD6 2 MET X 118  ASP X 119  0                                        
SHEET    2 AD6 2 TYR X 122  PRO X 123 -1  O  TYR X 122   N  ASP X 119           
SHEET    1 AD7 6 ASP X 235  PHE X 238  0                                        
SHEET    2 AD7 6 GLY X 260  ASN X 270 -1  O  ARG X 268   N  ASP X 235           
SHEET    3 AD7 6 GLU X 193  PHE X 203 -1  N  MET X 200   O  PHE X 262           
SHEET    4 AD7 6 GLU X 170  VAL X 183 -1  N  PHE X 172   O  ARG X 201           
SHEET    5 AD7 6 LEU X 406  LEU X 420  1  O  ASP X 417   N  LEU X 181           
SHEET    6 AD7 6 ILE X 376  SER X 377 -1  N  ILE X 376   O  LEU X 420           
SHEET    1 AD8 6 ASP X 235  PHE X 238  0                                        
SHEET    2 AD8 6 GLY X 260  ASN X 270 -1  O  ARG X 268   N  ASP X 235           
SHEET    3 AD8 6 GLU X 193  PHE X 203 -1  N  MET X 200   O  PHE X 262           
SHEET    4 AD8 6 GLU X 170  VAL X 183 -1  N  PHE X 172   O  ARG X 201           
SHEET    5 AD8 6 LEU X 406  LEU X 420  1  O  ASP X 417   N  LEU X 181           
SHEET    6 AD8 6 GLU X 381  PRO X 383 -1  N  ILE X 382   O  THR X 413           
SHEET    1 AD9 3 ILE X 253  PHE X 255  0                                        
SHEET    2 AD9 3 LEU X 210  LEU X 214 -1  N  LEU X 212   O  ILE X 253           
SHEET    3 AD9 3 VAL X 392  LYS X 396 -1  O  LYS X 396   N  ARG X 211           
SHEET    1 AE1 4 ILE X 277  GLU X 280  0                                        
SHEET    2 AE1 4 ARG X 290  SER X 299 -1  O  LYS X 296   N  GLU X 280           
SHEET    3 AE1 4 GLU X 353  GLY X 361 -1  O  ALA X 358   N  TYR X 293           
SHEET    4 AE1 4 ASP X 321  THR X 327 -1  N  ASP X 321   O  GLY X 361           
SHEET    1 AE2 3 THR X 306  PRO X 315  0                                        
SHEET    2 AE2 3 GLU X 340  PRO X 349 -1  O  PHE X 348   N  ALA X 307           
SHEET    3 AE2 3 SER X 331  VAL X 335 -1  N  VAL X 335   O  GLU X 340           
SHEET    1 AE3 2 PHE X 385  THR X 386  0                                        
SHEET    2 AE3 2 PHE Z  68  PRO Z  69 -1  O  PHE Z  68   N  THR X 386           
SHEET    1 AE4 5 LEU b  14  TRP b  19  0                                        
SHEET    2 AE4 5 PHE b   4  PHE b   8 -1  N  LEU b   7   O  ARG b  15           
SHEET    3 AE4 5 TYR b  66  ILE b  71 -1  O  TYR b  66   N  PHE b   8           
SHEET    4 AE4 5 LEU b  55  TYR b  59 -1  N  VAL b  58   O  CYS b  69           
SHEET    5 AE4 5 PHE b  49  TRP b  52 -1  N  VAL b  50   O  LEU b  57           
SHEET    1 AE5 2 ILE b 118  ILE b 119  0                                        
SHEET    2 AE5 2 GLU b 122  ILE b 123 -1  O  GLU b 122   N  ILE b 119           
SHEET    1 AE6 3 ILE Z 101  HIS Z 102  0                                        
SHEET    2 AE6 3 LEU Z 181  PHE Z 185 -1  O  LEU Z 181   N  HIS Z 102           
SHEET    3 AE6 3 TYR Z 143  PRO Z 147 -1  N  LYS Z 144   O  ARG Z 184           
LINK         OG1 THR C  31                MG    MG C1002     1555   1555  2.32  
LINK         OG1 THR C  48                MG    MG C1002     1555   1555  2.72  
LINK         OG1 THR H  31                MG    MG H1002     1555   1555  2.34  
LINK         OG1 THR H  48                MG    MG H1002     1555   1555  2.50  
LINK         OG1 THR K  31                MG    MG K1002     1555   1555  2.30  
LINK         OG1 THR K  48                MG    MG K1002     1555   1555  2.75  
LINK         OG1 THR U  31                MG    MG U1002     1555   1555  2.35  
LINK         OG1 THR U  48                MG    MG U1002     1555   1555  2.48  
LINK         OG1 THR L  31                MG    MG L1002     1555   1555  2.28  
LINK         OG1 THR L  48                MG    MG L1002     1555   1555  2.76  
LINK         OG1 THR V  31                MG    MG V1002     1555   1555  2.34  
LINK         OG1 THR V  48                MG    MG V1002     1555   1555  2.51  
LINK         O1G GTP C1001                MG    MG C1002     1555   1555  1.88  
LINK         O3G GTP C1001                MG    MG C1002     1555   1555  2.36  
LINK         O2B GTP C1001                MG    MG C1002     1555   1555  2.19  
LINK         O1G GTP H1001                MG    MG H1002     1555   1555  2.37  
LINK         O2G GTP H1001                MG    MG H1002     1555   1555  1.89  
LINK         O1B GTP H1001                MG    MG H1002     1555   1555  2.19  
LINK         O1G GTP K1001                MG    MG K1002     1555   1555  1.89  
LINK         O3G GTP K1001                MG    MG K1002     1555   1555  2.37  
LINK         O2B GTP K1001                MG    MG K1002     1555   1555  2.19  
LINK         O1G GTP U1001                MG    MG U1002     1555   1555  2.36  
LINK         O2G GTP U1001                MG    MG U1002     1555   1555  1.89  
LINK         O1B GTP U1001                MG    MG U1002     1555   1555  2.19  
LINK         O1G GTP L1001                MG    MG L1002     1555   1555  1.89  
LINK         O3G GTP L1001                MG    MG L1002     1555   1555  2.36  
LINK         O2B GTP L1001                MG    MG L1002     1555   1555  2.19  
LINK         O1G GTP V1001                MG    MG V1002     1555   1555  2.36  
LINK         O2G GTP V1001                MG    MG V1002     1555   1555  1.89  
LINK         O1B GTP V1001                MG    MG V1002     1555   1555  2.19  
SITE     1 AC1 17 ASP C  26  ALA C  27  ALA C  28  GLY C  29                    
SITE     2 AC1 17 LYS C  30  THR C  31  THR C  32  THR C  45                    
SITE     3 AC1 17 ILE C  46  PRO C  47  THR C  48  GLY C  69                    
SITE     4 AC1 17 LYS C 127  ASP C 129  ALA C 160  THR C 161                    
SITE     5 AC1 17  MG C1002                                                     
SITE     1 AC2  3 THR C  31  THR C  48  GTP C1001                               
SITE     1 AC3 18 ALA H  27  ALA H  28  GLY H  29  LYS H  30                    
SITE     2 AC3 18 THR H  31  THR H  32  THR H  45  ILE H  46                    
SITE     3 AC3 18 PRO H  47  THR H  48  GLY H  69  LEU H  71                    
SITE     4 AC3 18 ASN H 126  LYS H 127  ASP H 129  ALA H 160                    
SITE     5 AC3 18 THR H 161   MG H1002                                          
SITE     1 AC4  3 THR H  31  THR H  48  GTP H1001                               
SITE     1 AC5 17 ASP K  26  ALA K  27  ALA K  28  GLY K  29                    
SITE     2 AC5 17 LYS K  30  THR K  31  THR K  32  THR K  45                    
SITE     3 AC5 17 ILE K  46  PRO K  47  THR K  48  GLY K  69                    
SITE     4 AC5 17 LYS K 127  ASP K 129  ALA K 160  THR K 161                    
SITE     5 AC5 17  MG K1002                                                     
SITE     1 AC6  3 THR K  31  THR K  48  GTP K1001                               
SITE     1 AC7 18 ALA U  27  ALA U  28  GLY U  29  LYS U  30                    
SITE     2 AC7 18 THR U  31  THR U  32  THR U  45  ILE U  46                    
SITE     3 AC7 18 PRO U  47  THR U  48  GLY U  69  LEU U  71                    
SITE     4 AC7 18 ASN U 126  LYS U 127  ASP U 129  ALA U 160                    
SITE     5 AC7 18 THR U 161   MG U1002                                          
SITE     1 AC8  3 THR U  31  THR U  48  GTP U1001                               
SITE     1 AC9 17 ASP L  26  ALA L  27  ALA L  28  GLY L  29                    
SITE     2 AC9 17 LYS L  30  THR L  31  THR L  32  THR L  45                    
SITE     3 AC9 17 ILE L  46  PRO L  47  THR L  48  GLY L  69                    
SITE     4 AC9 17 LYS L 127  ASP L 129  ALA L 160  THR L 161                    
SITE     5 AC9 17  MG L1002                                                     
SITE     1 AD1  3 THR L  31  THR L  48  GTP L1001                               
SITE     1 AD2 18 ALA V  27  ALA V  28  GLY V  29  LYS V  30                    
SITE     2 AD2 18 THR V  31  THR V  32  THR V  45  ILE V  46                    
SITE     3 AD2 18 PRO V  47  THR V  48  GLY V  69  LEU V  71                    
SITE     4 AD2 18 ASN V 126  LYS V 127  ASP V 129  ALA V 160                    
SITE     5 AD2 18 THR V 161   MG V1002                                          
SITE     1 AD3  3 THR V  31  THR V  48  GTP V1001                               
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system