GenomeNet

Database: PDB
Entry: 6D7S
LinkDB: 6D7S
Original site: 6D7S 
HEADER    MEMBRANE PROTEIN                        25-APR-18   6D7S              
TITLE     CRYO-EM STRUCTURE OF HUMAN TRPV6-Y467A IN AMPHIPOLS                   
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V    
COMPND   3 MEMBER 6;                                                            
COMPND   4 CHAIN: A, B, C, D;                                                   
COMPND   5 SYNONYM: TRPV6,CAT-LIKE,CAT-L,CALCIUM TRANSPORT PROTEIN 1,CAT1,      
COMPND   6 EPITHELIAL CALCIUM CHANNEL 2,ECAC2;                                  
COMPND   7 ENGINEERED: YES;                                                     
COMPND   8 MUTATION: YES                                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: TRPV6, ECAC2;                                                  
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    ION CHANNELS, TRANSPORTER, CALCIUM CHANNEL, EPITHELIAL CALCIUM        
KEYWDS   2 CHANNEL, MEMBRANE PROTEIN                                            
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    A.K.SINGH,K.SAOTOME,L.L.MCGOLDRICK,A.I.SOBOLEVSKY                     
REVDAT   2   18-DEC-19 6D7S    1       SCALE                                    
REVDAT   1   18-JUL-18 6D7S    0                                                
JRNL        AUTH   A.K.SINGH,K.SAOTOME,L.L.MCGOLDRICK,A.I.SOBOLEVSKY            
JRNL        TITL   STRUCTURAL BASES OF TRP CHANNEL TRPV6 ALLOSTERIC MODULATION  
JRNL        TITL 2 BY 2-APB.                                                    
JRNL        REF    NAT COMMUN                    V.   9  2465 2018              
JRNL        REFN                   ESSN 2041-1723                               
JRNL        PMID   29941865                                                     
JRNL        DOI    10.1038/S41467-018-04828-Y                                   
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.34 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION, MOTIONCORR2, RELION               
REMARK   3   RECONSTRUCTION SCHEMA  : FOURIER SPACE                             
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.340                          
REMARK   3   NUMBER OF PARTICLES               : 115126                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6D7S COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 26-APR-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000234133.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : TRPV6 IN AMPHIPOLS                
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.50                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI F30                 
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 67.00                          
REMARK 245   ILLUMINATION MODE                 : SPOT SCAN                      
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     GLY A     2                                                      
REMARK 465     LEU A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     LEU A     5                                                      
REMARK 465     PRO A     6                                                      
REMARK 465     LYS A     7                                                      
REMARK 465     GLU A     8                                                      
REMARK 465     LYS A     9                                                      
REMARK 465     GLY A    10                                                      
REMARK 465     LEU A    11                                                      
REMARK 465     ILE A    12                                                      
REMARK 465     LEU A    13                                                      
REMARK 465     CYS A    14                                                      
REMARK 465     LEU A    15                                                      
REMARK 465     TRP A    16                                                      
REMARK 465     SER A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     PHE A    19                                                      
REMARK 465     CYS A    20                                                      
REMARK 465     ARG A    21                                                      
REMARK 465     TRP A    22                                                      
REMARK 465     PHE A    23                                                      
REMARK 465     GLN A    24                                                      
REMARK 465     ARG A    25                                                      
REMARK 465     ARG A    26                                                      
REMARK 465     GLU A    27                                                      
REMARK 465     ASP A   406                                                      
REMARK 465     ILE A   407                                                      
REMARK 465     PHE A   408                                                      
REMARK 465     ARG A   409                                                      
REMARK 465     MET A   410                                                      
REMARK 465     GLY A   411                                                      
REMARK 465     VAL A   412                                                      
REMARK 465     THR A   413                                                      
REMARK 465     ARG A   414                                                      
REMARK 465     PHE A   415                                                      
REMARK 465     PHE A   416                                                      
REMARK 465     GLY A   417                                                      
REMARK 465     GLN A   418                                                      
REMARK 465     THR A   419                                                      
REMARK 465     ILE A   420                                                      
REMARK 465     LEU A   421                                                      
REMARK 465     GLY A   422                                                      
REMARK 465     GLY A   423                                                      
REMARK 465     LEU A   639                                                      
REMARK 465     ASN A   640                                                      
REMARK 465     ARG A   641                                                      
REMARK 465     GLN A   642                                                      
REMARK 465     ARG A   643                                                      
REMARK 465     ILE A   644                                                      
REMARK 465     GLN A   645                                                      
REMARK 465     ARG A   646                                                      
REMARK 465     TYR A   647                                                      
REMARK 465     ALA A   648                                                      
REMARK 465     GLN A   649                                                      
REMARK 465     ALA A   650                                                      
REMARK 465     PHE A   651                                                      
REMARK 465     HIS A   652                                                      
REMARK 465     THR A   653                                                      
REMARK 465     ARG A   654                                                      
REMARK 465     GLY A   655                                                      
REMARK 465     SER A   656                                                      
REMARK 465     GLU A   657                                                      
REMARK 465     ASP A   658                                                      
REMARK 465     LEU A   659                                                      
REMARK 465     ASP A   660                                                      
REMARK 465     LYS A   661                                                      
REMARK 465     ASP A   662                                                      
REMARK 465     SER A   663                                                      
REMARK 465     VAL A   664                                                      
REMARK 465     GLU A   665                                                      
REMARK 465     LYS A   666                                                      
REMARK 465     LEU A   667                                                      
REMARK 465     GLU A   668                                                      
REMARK 465     LEU A   669                                                      
REMARK 465     GLY A   670                                                      
REMARK 465     CYS A   671                                                      
REMARK 465     PRO A   672                                                      
REMARK 465     PHE A   673                                                      
REMARK 465     SER A   674                                                      
REMARK 465     PRO A   675                                                      
REMARK 465     HIS A   676                                                      
REMARK 465     LEU A   677                                                      
REMARK 465     SER A   678                                                      
REMARK 465     LEU A   679                                                      
REMARK 465     PRO A   680                                                      
REMARK 465     MET A   681                                                      
REMARK 465     PRO A   682                                                      
REMARK 465     SER A   683                                                      
REMARK 465     VAL A   684                                                      
REMARK 465     SER A   685                                                      
REMARK 465     ARG A   686                                                      
REMARK 465     SER A   687                                                      
REMARK 465     THR A   688                                                      
REMARK 465     SER A   689                                                      
REMARK 465     ARG A   690                                                      
REMARK 465     SER A   691                                                      
REMARK 465     SER A   692                                                      
REMARK 465     ALA A   693                                                      
REMARK 465     ASN A   694                                                      
REMARK 465     TRP A   695                                                      
REMARK 465     GLU A   696                                                      
REMARK 465     ARG A   697                                                      
REMARK 465     LEU A   698                                                      
REMARK 465     ARG A   699                                                      
REMARK 465     GLN A   700                                                      
REMARK 465     GLY A   701                                                      
REMARK 465     THR A   702                                                      
REMARK 465     LEU A   703                                                      
REMARK 465     ARG A   704                                                      
REMARK 465     ARG A   705                                                      
REMARK 465     ASP A   706                                                      
REMARK 465     LEU A   707                                                      
REMARK 465     ARG A   708                                                      
REMARK 465     GLY A   709                                                      
REMARK 465     ILE A   710                                                      
REMARK 465     ILE A   711                                                      
REMARK 465     ASN A   712                                                      
REMARK 465     ARG A   713                                                      
REMARK 465     GLY A   714                                                      
REMARK 465     LEU A   715                                                      
REMARK 465     GLU A   716                                                      
REMARK 465     ASP A   717                                                      
REMARK 465     GLY A   718                                                      
REMARK 465     GLU A   719                                                      
REMARK 465     SER A   720                                                      
REMARK 465     TRP A   721                                                      
REMARK 465     GLU A   722                                                      
REMARK 465     TYR A   723                                                      
REMARK 465     GLN A   724                                                      
REMARK 465     ILE A   725                                                      
REMARK 465     LEU A   726                                                      
REMARK 465     VAL A   727                                                      
REMARK 465     PRO A   728                                                      
REMARK 465     ARG A   729                                                      
REMARK 465     GLY A   730                                                      
REMARK 465     SER A   731                                                      
REMARK 465     ALA A   732                                                      
REMARK 465     ALA A   733                                                      
REMARK 465     ALA A   734                                                      
REMARK 465     TRP A   735                                                      
REMARK 465     SER A   736                                                      
REMARK 465     HIS A   737                                                      
REMARK 465     PRO A   738                                                      
REMARK 465     GLN A   739                                                      
REMARK 465     PHE A   740                                                      
REMARK 465     GLU A   741                                                      
REMARK 465     LYS A   742                                                      
REMARK 465     MET B     1                                                      
REMARK 465     GLY B     2                                                      
REMARK 465     LEU B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     LEU B     5                                                      
REMARK 465     PRO B     6                                                      
REMARK 465     LYS B     7                                                      
REMARK 465     GLU B     8                                                      
REMARK 465     LYS B     9                                                      
REMARK 465     GLY B    10                                                      
REMARK 465     LEU B    11                                                      
REMARK 465     ILE B    12                                                      
REMARK 465     LEU B    13                                                      
REMARK 465     CYS B    14                                                      
REMARK 465     LEU B    15                                                      
REMARK 465     TRP B    16                                                      
REMARK 465     SER B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     PHE B    19                                                      
REMARK 465     CYS B    20                                                      
REMARK 465     ARG B    21                                                      
REMARK 465     TRP B    22                                                      
REMARK 465     PHE B    23                                                      
REMARK 465     GLN B    24                                                      
REMARK 465     ARG B    25                                                      
REMARK 465     ARG B    26                                                      
REMARK 465     GLU B    27                                                      
REMARK 465     ASP B   406                                                      
REMARK 465     ILE B   407                                                      
REMARK 465     PHE B   408                                                      
REMARK 465     ARG B   409                                                      
REMARK 465     MET B   410                                                      
REMARK 465     GLY B   411                                                      
REMARK 465     VAL B   412                                                      
REMARK 465     THR B   413                                                      
REMARK 465     ARG B   414                                                      
REMARK 465     PHE B   415                                                      
REMARK 465     PHE B   416                                                      
REMARK 465     GLY B   417                                                      
REMARK 465     GLN B   418                                                      
REMARK 465     THR B   419                                                      
REMARK 465     ILE B   420                                                      
REMARK 465     LEU B   421                                                      
REMARK 465     GLY B   422                                                      
REMARK 465     GLY B   423                                                      
REMARK 465     LEU B   639                                                      
REMARK 465     ASN B   640                                                      
REMARK 465     ARG B   641                                                      
REMARK 465     GLN B   642                                                      
REMARK 465     ARG B   643                                                      
REMARK 465     ILE B   644                                                      
REMARK 465     GLN B   645                                                      
REMARK 465     ARG B   646                                                      
REMARK 465     TYR B   647                                                      
REMARK 465     ALA B   648                                                      
REMARK 465     GLN B   649                                                      
REMARK 465     ALA B   650                                                      
REMARK 465     PHE B   651                                                      
REMARK 465     HIS B   652                                                      
REMARK 465     THR B   653                                                      
REMARK 465     ARG B   654                                                      
REMARK 465     GLY B   655                                                      
REMARK 465     SER B   656                                                      
REMARK 465     GLU B   657                                                      
REMARK 465     ASP B   658                                                      
REMARK 465     LEU B   659                                                      
REMARK 465     ASP B   660                                                      
REMARK 465     LYS B   661                                                      
REMARK 465     ASP B   662                                                      
REMARK 465     SER B   663                                                      
REMARK 465     VAL B   664                                                      
REMARK 465     GLU B   665                                                      
REMARK 465     LYS B   666                                                      
REMARK 465     LEU B   667                                                      
REMARK 465     GLU B   668                                                      
REMARK 465     LEU B   669                                                      
REMARK 465     GLY B   670                                                      
REMARK 465     CYS B   671                                                      
REMARK 465     PRO B   672                                                      
REMARK 465     PHE B   673                                                      
REMARK 465     SER B   674                                                      
REMARK 465     PRO B   675                                                      
REMARK 465     HIS B   676                                                      
REMARK 465     LEU B   677                                                      
REMARK 465     SER B   678                                                      
REMARK 465     LEU B   679                                                      
REMARK 465     PRO B   680                                                      
REMARK 465     MET B   681                                                      
REMARK 465     PRO B   682                                                      
REMARK 465     SER B   683                                                      
REMARK 465     VAL B   684                                                      
REMARK 465     SER B   685                                                      
REMARK 465     ARG B   686                                                      
REMARK 465     SER B   687                                                      
REMARK 465     THR B   688                                                      
REMARK 465     SER B   689                                                      
REMARK 465     ARG B   690                                                      
REMARK 465     SER B   691                                                      
REMARK 465     SER B   692                                                      
REMARK 465     ALA B   693                                                      
REMARK 465     ASN B   694                                                      
REMARK 465     TRP B   695                                                      
REMARK 465     GLU B   696                                                      
REMARK 465     ARG B   697                                                      
REMARK 465     LEU B   698                                                      
REMARK 465     ARG B   699                                                      
REMARK 465     GLN B   700                                                      
REMARK 465     GLY B   701                                                      
REMARK 465     THR B   702                                                      
REMARK 465     LEU B   703                                                      
REMARK 465     ARG B   704                                                      
REMARK 465     ARG B   705                                                      
REMARK 465     ASP B   706                                                      
REMARK 465     LEU B   707                                                      
REMARK 465     ARG B   708                                                      
REMARK 465     GLY B   709                                                      
REMARK 465     ILE B   710                                                      
REMARK 465     ILE B   711                                                      
REMARK 465     ASN B   712                                                      
REMARK 465     ARG B   713                                                      
REMARK 465     GLY B   714                                                      
REMARK 465     LEU B   715                                                      
REMARK 465     GLU B   716                                                      
REMARK 465     ASP B   717                                                      
REMARK 465     GLY B   718                                                      
REMARK 465     GLU B   719                                                      
REMARK 465     SER B   720                                                      
REMARK 465     TRP B   721                                                      
REMARK 465     GLU B   722                                                      
REMARK 465     TYR B   723                                                      
REMARK 465     GLN B   724                                                      
REMARK 465     ILE B   725                                                      
REMARK 465     LEU B   726                                                      
REMARK 465     VAL B   727                                                      
REMARK 465     PRO B   728                                                      
REMARK 465     ARG B   729                                                      
REMARK 465     GLY B   730                                                      
REMARK 465     SER B   731                                                      
REMARK 465     ALA B   732                                                      
REMARK 465     ALA B   733                                                      
REMARK 465     ALA B   734                                                      
REMARK 465     TRP B   735                                                      
REMARK 465     SER B   736                                                      
REMARK 465     HIS B   737                                                      
REMARK 465     PRO B   738                                                      
REMARK 465     GLN B   739                                                      
REMARK 465     PHE B   740                                                      
REMARK 465     GLU B   741                                                      
REMARK 465     LYS B   742                                                      
REMARK 465     MET C     1                                                      
REMARK 465     GLY C     2                                                      
REMARK 465     LEU C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     LEU C     5                                                      
REMARK 465     PRO C     6                                                      
REMARK 465     LYS C     7                                                      
REMARK 465     GLU C     8                                                      
REMARK 465     LYS C     9                                                      
REMARK 465     GLY C    10                                                      
REMARK 465     LEU C    11                                                      
REMARK 465     ILE C    12                                                      
REMARK 465     LEU C    13                                                      
REMARK 465     CYS C    14                                                      
REMARK 465     LEU C    15                                                      
REMARK 465     TRP C    16                                                      
REMARK 465     SER C    17                                                      
REMARK 465     LYS C    18                                                      
REMARK 465     PHE C    19                                                      
REMARK 465     CYS C    20                                                      
REMARK 465     ARG C    21                                                      
REMARK 465     TRP C    22                                                      
REMARK 465     PHE C    23                                                      
REMARK 465     GLN C    24                                                      
REMARK 465     ARG C    25                                                      
REMARK 465     ARG C    26                                                      
REMARK 465     GLU C    27                                                      
REMARK 465     ASP C   406                                                      
REMARK 465     ILE C   407                                                      
REMARK 465     PHE C   408                                                      
REMARK 465     ARG C   409                                                      
REMARK 465     MET C   410                                                      
REMARK 465     GLY C   411                                                      
REMARK 465     VAL C   412                                                      
REMARK 465     THR C   413                                                      
REMARK 465     ARG C   414                                                      
REMARK 465     PHE C   415                                                      
REMARK 465     PHE C   416                                                      
REMARK 465     GLY C   417                                                      
REMARK 465     GLN C   418                                                      
REMARK 465     THR C   419                                                      
REMARK 465     ILE C   420                                                      
REMARK 465     LEU C   421                                                      
REMARK 465     GLY C   422                                                      
REMARK 465     GLY C   423                                                      
REMARK 465     LEU C   639                                                      
REMARK 465     ASN C   640                                                      
REMARK 465     ARG C   641                                                      
REMARK 465     GLN C   642                                                      
REMARK 465     ARG C   643                                                      
REMARK 465     ILE C   644                                                      
REMARK 465     GLN C   645                                                      
REMARK 465     ARG C   646                                                      
REMARK 465     TYR C   647                                                      
REMARK 465     ALA C   648                                                      
REMARK 465     GLN C   649                                                      
REMARK 465     ALA C   650                                                      
REMARK 465     PHE C   651                                                      
REMARK 465     HIS C   652                                                      
REMARK 465     THR C   653                                                      
REMARK 465     ARG C   654                                                      
REMARK 465     GLY C   655                                                      
REMARK 465     SER C   656                                                      
REMARK 465     GLU C   657                                                      
REMARK 465     ASP C   658                                                      
REMARK 465     LEU C   659                                                      
REMARK 465     ASP C   660                                                      
REMARK 465     LYS C   661                                                      
REMARK 465     ASP C   662                                                      
REMARK 465     SER C   663                                                      
REMARK 465     VAL C   664                                                      
REMARK 465     GLU C   665                                                      
REMARK 465     LYS C   666                                                      
REMARK 465     LEU C   667                                                      
REMARK 465     GLU C   668                                                      
REMARK 465     LEU C   669                                                      
REMARK 465     GLY C   670                                                      
REMARK 465     CYS C   671                                                      
REMARK 465     PRO C   672                                                      
REMARK 465     PHE C   673                                                      
REMARK 465     SER C   674                                                      
REMARK 465     PRO C   675                                                      
REMARK 465     HIS C   676                                                      
REMARK 465     LEU C   677                                                      
REMARK 465     SER C   678                                                      
REMARK 465     LEU C   679                                                      
REMARK 465     PRO C   680                                                      
REMARK 465     MET C   681                                                      
REMARK 465     PRO C   682                                                      
REMARK 465     SER C   683                                                      
REMARK 465     VAL C   684                                                      
REMARK 465     SER C   685                                                      
REMARK 465     ARG C   686                                                      
REMARK 465     SER C   687                                                      
REMARK 465     THR C   688                                                      
REMARK 465     SER C   689                                                      
REMARK 465     ARG C   690                                                      
REMARK 465     SER C   691                                                      
REMARK 465     SER C   692                                                      
REMARK 465     ALA C   693                                                      
REMARK 465     ASN C   694                                                      
REMARK 465     TRP C   695                                                      
REMARK 465     GLU C   696                                                      
REMARK 465     ARG C   697                                                      
REMARK 465     LEU C   698                                                      
REMARK 465     ARG C   699                                                      
REMARK 465     GLN C   700                                                      
REMARK 465     GLY C   701                                                      
REMARK 465     THR C   702                                                      
REMARK 465     LEU C   703                                                      
REMARK 465     ARG C   704                                                      
REMARK 465     ARG C   705                                                      
REMARK 465     ASP C   706                                                      
REMARK 465     LEU C   707                                                      
REMARK 465     ARG C   708                                                      
REMARK 465     GLY C   709                                                      
REMARK 465     ILE C   710                                                      
REMARK 465     ILE C   711                                                      
REMARK 465     ASN C   712                                                      
REMARK 465     ARG C   713                                                      
REMARK 465     GLY C   714                                                      
REMARK 465     LEU C   715                                                      
REMARK 465     GLU C   716                                                      
REMARK 465     ASP C   717                                                      
REMARK 465     GLY C   718                                                      
REMARK 465     GLU C   719                                                      
REMARK 465     SER C   720                                                      
REMARK 465     TRP C   721                                                      
REMARK 465     GLU C   722                                                      
REMARK 465     TYR C   723                                                      
REMARK 465     GLN C   724                                                      
REMARK 465     ILE C   725                                                      
REMARK 465     LEU C   726                                                      
REMARK 465     VAL C   727                                                      
REMARK 465     PRO C   728                                                      
REMARK 465     ARG C   729                                                      
REMARK 465     GLY C   730                                                      
REMARK 465     SER C   731                                                      
REMARK 465     ALA C   732                                                      
REMARK 465     ALA C   733                                                      
REMARK 465     ALA C   734                                                      
REMARK 465     TRP C   735                                                      
REMARK 465     SER C   736                                                      
REMARK 465     HIS C   737                                                      
REMARK 465     PRO C   738                                                      
REMARK 465     GLN C   739                                                      
REMARK 465     PHE C   740                                                      
REMARK 465     GLU C   741                                                      
REMARK 465     LYS C   742                                                      
REMARK 465     MET D     1                                                      
REMARK 465     GLY D     2                                                      
REMARK 465     LEU D     3                                                      
REMARK 465     SER D     4                                                      
REMARK 465     LEU D     5                                                      
REMARK 465     PRO D     6                                                      
REMARK 465     LYS D     7                                                      
REMARK 465     GLU D     8                                                      
REMARK 465     LYS D     9                                                      
REMARK 465     GLY D    10                                                      
REMARK 465     LEU D    11                                                      
REMARK 465     ILE D    12                                                      
REMARK 465     LEU D    13                                                      
REMARK 465     CYS D    14                                                      
REMARK 465     LEU D    15                                                      
REMARK 465     TRP D    16                                                      
REMARK 465     SER D    17                                                      
REMARK 465     LYS D    18                                                      
REMARK 465     PHE D    19                                                      
REMARK 465     CYS D    20                                                      
REMARK 465     ARG D    21                                                      
REMARK 465     TRP D    22                                                      
REMARK 465     PHE D    23                                                      
REMARK 465     GLN D    24                                                      
REMARK 465     ARG D    25                                                      
REMARK 465     ARG D    26                                                      
REMARK 465     GLU D    27                                                      
REMARK 465     ASP D   406                                                      
REMARK 465     ILE D   407                                                      
REMARK 465     PHE D   408                                                      
REMARK 465     ARG D   409                                                      
REMARK 465     MET D   410                                                      
REMARK 465     GLY D   411                                                      
REMARK 465     VAL D   412                                                      
REMARK 465     THR D   413                                                      
REMARK 465     ARG D   414                                                      
REMARK 465     PHE D   415                                                      
REMARK 465     PHE D   416                                                      
REMARK 465     GLY D   417                                                      
REMARK 465     GLN D   418                                                      
REMARK 465     THR D   419                                                      
REMARK 465     ILE D   420                                                      
REMARK 465     LEU D   421                                                      
REMARK 465     GLY D   422                                                      
REMARK 465     GLY D   423                                                      
REMARK 465     LEU D   639                                                      
REMARK 465     ASN D   640                                                      
REMARK 465     ARG D   641                                                      
REMARK 465     GLN D   642                                                      
REMARK 465     ARG D   643                                                      
REMARK 465     ILE D   644                                                      
REMARK 465     GLN D   645                                                      
REMARK 465     ARG D   646                                                      
REMARK 465     TYR D   647                                                      
REMARK 465     ALA D   648                                                      
REMARK 465     GLN D   649                                                      
REMARK 465     ALA D   650                                                      
REMARK 465     PHE D   651                                                      
REMARK 465     HIS D   652                                                      
REMARK 465     THR D   653                                                      
REMARK 465     ARG D   654                                                      
REMARK 465     GLY D   655                                                      
REMARK 465     SER D   656                                                      
REMARK 465     GLU D   657                                                      
REMARK 465     ASP D   658                                                      
REMARK 465     LEU D   659                                                      
REMARK 465     ASP D   660                                                      
REMARK 465     LYS D   661                                                      
REMARK 465     ASP D   662                                                      
REMARK 465     SER D   663                                                      
REMARK 465     VAL D   664                                                      
REMARK 465     GLU D   665                                                      
REMARK 465     LYS D   666                                                      
REMARK 465     LEU D   667                                                      
REMARK 465     GLU D   668                                                      
REMARK 465     LEU D   669                                                      
REMARK 465     GLY D   670                                                      
REMARK 465     CYS D   671                                                      
REMARK 465     PRO D   672                                                      
REMARK 465     PHE D   673                                                      
REMARK 465     SER D   674                                                      
REMARK 465     PRO D   675                                                      
REMARK 465     HIS D   676                                                      
REMARK 465     LEU D   677                                                      
REMARK 465     SER D   678                                                      
REMARK 465     LEU D   679                                                      
REMARK 465     PRO D   680                                                      
REMARK 465     MET D   681                                                      
REMARK 465     PRO D   682                                                      
REMARK 465     SER D   683                                                      
REMARK 465     VAL D   684                                                      
REMARK 465     SER D   685                                                      
REMARK 465     ARG D   686                                                      
REMARK 465     SER D   687                                                      
REMARK 465     THR D   688                                                      
REMARK 465     SER D   689                                                      
REMARK 465     ARG D   690                                                      
REMARK 465     SER D   691                                                      
REMARK 465     SER D   692                                                      
REMARK 465     ALA D   693                                                      
REMARK 465     ASN D   694                                                      
REMARK 465     TRP D   695                                                      
REMARK 465     GLU D   696                                                      
REMARK 465     ARG D   697                                                      
REMARK 465     LEU D   698                                                      
REMARK 465     ARG D   699                                                      
REMARK 465     GLN D   700                                                      
REMARK 465     GLY D   701                                                      
REMARK 465     THR D   702                                                      
REMARK 465     LEU D   703                                                      
REMARK 465     ARG D   704                                                      
REMARK 465     ARG D   705                                                      
REMARK 465     ASP D   706                                                      
REMARK 465     LEU D   707                                                      
REMARK 465     ARG D   708                                                      
REMARK 465     GLY D   709                                                      
REMARK 465     ILE D   710                                                      
REMARK 465     ILE D   711                                                      
REMARK 465     ASN D   712                                                      
REMARK 465     ARG D   713                                                      
REMARK 465     GLY D   714                                                      
REMARK 465     LEU D   715                                                      
REMARK 465     GLU D   716                                                      
REMARK 465     ASP D   717                                                      
REMARK 465     GLY D   718                                                      
REMARK 465     GLU D   719                                                      
REMARK 465     SER D   720                                                      
REMARK 465     TRP D   721                                                      
REMARK 465     GLU D   722                                                      
REMARK 465     TYR D   723                                                      
REMARK 465     GLN D   724                                                      
REMARK 465     ILE D   725                                                      
REMARK 465     LEU D   726                                                      
REMARK 465     VAL D   727                                                      
REMARK 465     PRO D   728                                                      
REMARK 465     ARG D   729                                                      
REMARK 465     GLY D   730                                                      
REMARK 465     SER D   731                                                      
REMARK 465     ALA D   732                                                      
REMARK 465     ALA D   733                                                      
REMARK 465     ALA D   734                                                      
REMARK 465     TRP D   735                                                      
REMARK 465     SER D   736                                                      
REMARK 465     HIS D   737                                                      
REMARK 465     PRO D   738                                                      
REMARK 465     GLN D   739                                                      
REMARK 465     PHE D   740                                                      
REMARK 465     GLU D   741                                                      
REMARK 465     LYS D   742                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     PHE B 343    N                                                   
REMARK 470     THR B 344    N                                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A 372   CA  -  CB  -  CG  ANGL. DEV. =  19.3 DEGREES          
REMARK 500    LEU B 372   CA  -  CB  -  CG  ANGL. DEV. =  19.4 DEGREES          
REMARK 500    LEU C 372   CA  -  CB  -  CG  ANGL. DEV. =  19.4 DEGREES          
REMARK 500    LEU D 372   CA  -  CB  -  CG  ANGL. DEV. =  19.3 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    HIS A  73       38.06    -97.93                                   
REMARK 500    GLU A 113      -19.12     75.95                                   
REMARK 500    LEU A 114      -40.03   -131.78                                   
REMARK 500    ASN A 127       30.13    -91.81                                   
REMARK 500    GLN A 128      -18.81     73.15                                   
REMARK 500    ASN A 129      158.42    177.88                                   
REMARK 500    ASN A 131       -7.92     67.88                                   
REMARK 500    ASP A 223       40.49    -99.41                                   
REMARK 500    HIS A 228       -8.17     70.55                                   
REMARK 500    GLN A 230       78.87     51.82                                   
REMARK 500    PRO A 231       68.59    -69.37                                   
REMARK 500    LEU A 232      -14.27     71.36                                   
REMARK 500    GLN A 267     -159.73    -91.90                                   
REMARK 500    GLN A 290      -13.44     71.47                                   
REMARK 500    TYR A 324      -11.27     73.09                                   
REMARK 500    LEU A 352       74.30     52.68                                   
REMARK 500    ASN A 365     -156.82   -148.89                                   
REMARK 500    THR A 366      109.04    -57.69                                   
REMARK 500    LEU A 368      149.24   -172.05                                   
REMARK 500    GLN A 369       16.38   -144.80                                   
REMARK 500    LEU A 372       82.11     59.34                                   
REMARK 500    LEU A 373      140.53    -36.18                                   
REMARK 500    GLU A 375       24.14   -140.99                                   
REMARK 500    THR A 379       82.59     56.07                                   
REMARK 500    PRO A 380       -0.67    -58.46                                   
REMARK 500    GLU A 403       41.49   -104.13                                   
REMARK 500    GLN A 473      134.71    -34.09                                   
REMARK 500    MET A 474       11.48     80.35                                   
REMARK 500    ILE A 540      -59.82   -122.38                                   
REMARK 500    TYR A 547       -8.03     72.62                                   
REMARK 500    LEU A 569      -60.52    -93.87                                   
REMARK 500    ARG A 621       -8.43     70.71                                   
REMARK 500    LEU A 625      -31.94   -130.54                                   
REMARK 500    HIS B  73       38.12    -97.99                                   
REMARK 500    GLU B 113      -19.05     75.95                                   
REMARK 500    LEU B 114      -39.93   -131.83                                   
REMARK 500    ASN B 127       30.19    -91.83                                   
REMARK 500    GLN B 128      -18.78     73.06                                   
REMARK 500    ASN B 129      158.52    177.89                                   
REMARK 500    ASN B 131       -7.88     67.86                                   
REMARK 500    ASP B 223       40.46    -99.43                                   
REMARK 500    HIS B 228       -8.16     70.51                                   
REMARK 500    GLN B 230       78.81     51.77                                   
REMARK 500    PRO B 231       68.59    -69.30                                   
REMARK 500    LEU B 232      -14.24     71.37                                   
REMARK 500    GLN B 267     -159.76    -91.84                                   
REMARK 500    GLN B 290      -13.47     71.49                                   
REMARK 500    TYR B 324      -11.25     73.10                                   
REMARK 500    LEU B 352       74.29     52.72                                   
REMARK 500    ASN B 365     -156.79   -148.83                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     132 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-7824   RELATED DB: EMDB                              
REMARK 900 CRYO-EM STRUCTURE OF HUMAN TRPV6-Y467A IN AMPHIPOLS                  
DBREF  6D7S A    1   725  UNP    Q9H1D0   TRPV6_HUMAN     41    765             
DBREF  6D7S B    1   725  UNP    Q9H1D0   TRPV6_HUMAN     41    765             
DBREF  6D7S C    1   725  UNP    Q9H1D0   TRPV6_HUMAN     41    765             
DBREF  6D7S D    1   725  UNP    Q9H1D0   TRPV6_HUMAN     41    765             
SEQADV 6D7S ALA A  467  UNP  Q9H1D0    TYR   507 ENGINEERED MUTATION            
SEQADV 6D7S LEU A  726  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S VAL A  727  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PRO A  728  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ARG A  729  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLY A  730  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S SER A  731  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA A  732  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA A  733  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA A  734  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S TRP A  735  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S SER A  736  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S HIS A  737  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PRO A  738  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLN A  739  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PHE A  740  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLU A  741  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S LYS A  742  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA B  467  UNP  Q9H1D0    TYR   507 ENGINEERED MUTATION            
SEQADV 6D7S LEU B  726  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S VAL B  727  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PRO B  728  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ARG B  729  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLY B  730  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S SER B  731  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA B  732  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA B  733  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA B  734  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S TRP B  735  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S SER B  736  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S HIS B  737  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PRO B  738  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLN B  739  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PHE B  740  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLU B  741  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S LYS B  742  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA C  467  UNP  Q9H1D0    TYR   507 ENGINEERED MUTATION            
SEQADV 6D7S LEU C  726  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S VAL C  727  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PRO C  728  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ARG C  729  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLY C  730  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S SER C  731  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA C  732  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA C  733  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA C  734  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S TRP C  735  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S SER C  736  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S HIS C  737  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PRO C  738  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLN C  739  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PHE C  740  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLU C  741  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S LYS C  742  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA D  467  UNP  Q9H1D0    TYR   507 ENGINEERED MUTATION            
SEQADV 6D7S LEU D  726  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S VAL D  727  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PRO D  728  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ARG D  729  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLY D  730  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S SER D  731  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA D  732  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA D  733  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S ALA D  734  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S TRP D  735  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S SER D  736  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S HIS D  737  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PRO D  738  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLN D  739  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S PHE D  740  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S GLU D  741  UNP  Q9H1D0              EXPRESSION TAG                 
SEQADV 6D7S LYS D  742  UNP  Q9H1D0              EXPRESSION TAG                 
SEQRES   1 A  742  MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU          
SEQRES   2 A  742  CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG          
SEQRES   3 A  742  GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU          
SEQRES   4 A  742  GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA          
SEQRES   5 A  742  ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU          
SEQRES   6 A  742  LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET          
SEQRES   7 A  742  GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN          
SEQRES   8 A  742  LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU          
SEQRES   9 A  742  LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY          
SEQRES  10 A  742  GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET          
SEQRES  11 A  742  ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL          
SEQRES  12 A  742  SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO          
SEQRES  13 A  742  CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE          
SEQRES  14 A  742  ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU          
SEQRES  15 A  742  ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU          
SEQRES  16 A  742  GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN          
SEQRES  17 A  742  LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER          
SEQRES  18 A  742  TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU          
SEQRES  19 A  742  VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA          
SEQRES  20 A  742  GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET          
SEQRES  21 A  742  GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU          
SEQRES  22 A  742  THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER          
SEQRES  23 A  742  GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR          
SEQRES  24 A  742  LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO          
SEQRES  25 A  742  VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY          
SEQRES  26 A  742  ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU          
SEQRES  27 A  742  TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO          
SEQRES  28 A  742  LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP          
SEQRES  29 A  742  ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR          
SEQRES  30 A  742  MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU          
SEQRES  31 A  742  VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU          
SEQRES  32 A  742  VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE          
SEQRES  33 A  742  GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE          
SEQRES  34 A  742  ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET          
SEQRES  35 A  742  ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER          
SEQRES  36 A  742  PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET ALA PHE          
SEQRES  37 A  742  ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET          
SEQRES  38 A  742  ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS          
SEQRES  39 A  742  TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA          
SEQRES  40 A  742  PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU          
SEQRES  41 A  742  GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR          
SEQRES  42 A  742  PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN          
SEQRES  43 A  742  TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR          
SEQRES  44 A  742  ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN          
SEQRES  45 A  742  LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL          
SEQRES  46 A  742  ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL          
SEQRES  47 A  742  ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS          
SEQRES  48 A  742  LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY          
SEQRES  49 A  742  LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN          
SEQRES  50 A  742  ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA          
SEQRES  51 A  742  PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER          
SEQRES  52 A  742  VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS          
SEQRES  53 A  742  LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER          
SEQRES  54 A  742  ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR          
SEQRES  55 A  742  LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU          
SEQRES  56 A  742  GLU ASP GLY GLU SER TRP GLU TYR GLN ILE LEU VAL PRO          
SEQRES  57 A  742  ARG GLY SER ALA ALA ALA TRP SER HIS PRO GLN PHE GLU          
SEQRES  58 A  742  LYS                                                          
SEQRES   1 B  742  MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU          
SEQRES   2 B  742  CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG          
SEQRES   3 B  742  GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU          
SEQRES   4 B  742  GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA          
SEQRES   5 B  742  ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU          
SEQRES   6 B  742  LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET          
SEQRES   7 B  742  GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN          
SEQRES   8 B  742  LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU          
SEQRES   9 B  742  LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY          
SEQRES  10 B  742  GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET          
SEQRES  11 B  742  ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL          
SEQRES  12 B  742  SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO          
SEQRES  13 B  742  CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE          
SEQRES  14 B  742  ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU          
SEQRES  15 B  742  ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU          
SEQRES  16 B  742  GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN          
SEQRES  17 B  742  LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER          
SEQRES  18 B  742  TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU          
SEQRES  19 B  742  VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA          
SEQRES  20 B  742  GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET          
SEQRES  21 B  742  GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU          
SEQRES  22 B  742  THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER          
SEQRES  23 B  742  GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR          
SEQRES  24 B  742  LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO          
SEQRES  25 B  742  VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY          
SEQRES  26 B  742  ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU          
SEQRES  27 B  742  TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO          
SEQRES  28 B  742  LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP          
SEQRES  29 B  742  ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR          
SEQRES  30 B  742  MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU          
SEQRES  31 B  742  VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU          
SEQRES  32 B  742  VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE          
SEQRES  33 B  742  GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE          
SEQRES  34 B  742  ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET          
SEQRES  35 B  742  ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER          
SEQRES  36 B  742  PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET ALA PHE          
SEQRES  37 B  742  ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET          
SEQRES  38 B  742  ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS          
SEQRES  39 B  742  TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA          
SEQRES  40 B  742  PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU          
SEQRES  41 B  742  GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR          
SEQRES  42 B  742  PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN          
SEQRES  43 B  742  TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR          
SEQRES  44 B  742  ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN          
SEQRES  45 B  742  LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL          
SEQRES  46 B  742  ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL          
SEQRES  47 B  742  ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS          
SEQRES  48 B  742  LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY          
SEQRES  49 B  742  LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN          
SEQRES  50 B  742  ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA          
SEQRES  51 B  742  PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER          
SEQRES  52 B  742  VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS          
SEQRES  53 B  742  LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER          
SEQRES  54 B  742  ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR          
SEQRES  55 B  742  LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU          
SEQRES  56 B  742  GLU ASP GLY GLU SER TRP GLU TYR GLN ILE LEU VAL PRO          
SEQRES  57 B  742  ARG GLY SER ALA ALA ALA TRP SER HIS PRO GLN PHE GLU          
SEQRES  58 B  742  LYS                                                          
SEQRES   1 C  742  MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU          
SEQRES   2 C  742  CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG          
SEQRES   3 C  742  GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU          
SEQRES   4 C  742  GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA          
SEQRES   5 C  742  ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU          
SEQRES   6 C  742  LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET          
SEQRES   7 C  742  GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN          
SEQRES   8 C  742  LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU          
SEQRES   9 C  742  LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY          
SEQRES  10 C  742  GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET          
SEQRES  11 C  742  ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL          
SEQRES  12 C  742  SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO          
SEQRES  13 C  742  CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE          
SEQRES  14 C  742  ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU          
SEQRES  15 C  742  ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU          
SEQRES  16 C  742  GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN          
SEQRES  17 C  742  LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER          
SEQRES  18 C  742  TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU          
SEQRES  19 C  742  VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA          
SEQRES  20 C  742  GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET          
SEQRES  21 C  742  GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU          
SEQRES  22 C  742  THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER          
SEQRES  23 C  742  GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR          
SEQRES  24 C  742  LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO          
SEQRES  25 C  742  VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY          
SEQRES  26 C  742  ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU          
SEQRES  27 C  742  TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO          
SEQRES  28 C  742  LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP          
SEQRES  29 C  742  ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR          
SEQRES  30 C  742  MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU          
SEQRES  31 C  742  VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU          
SEQRES  32 C  742  VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE          
SEQRES  33 C  742  GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE          
SEQRES  34 C  742  ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET          
SEQRES  35 C  742  ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER          
SEQRES  36 C  742  PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET ALA PHE          
SEQRES  37 C  742  ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET          
SEQRES  38 C  742  ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS          
SEQRES  39 C  742  TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA          
SEQRES  40 C  742  PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU          
SEQRES  41 C  742  GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR          
SEQRES  42 C  742  PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN          
SEQRES  43 C  742  TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR          
SEQRES  44 C  742  ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN          
SEQRES  45 C  742  LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL          
SEQRES  46 C  742  ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL          
SEQRES  47 C  742  ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS          
SEQRES  48 C  742  LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY          
SEQRES  49 C  742  LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN          
SEQRES  50 C  742  ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA          
SEQRES  51 C  742  PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER          
SEQRES  52 C  742  VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS          
SEQRES  53 C  742  LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER          
SEQRES  54 C  742  ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR          
SEQRES  55 C  742  LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU          
SEQRES  56 C  742  GLU ASP GLY GLU SER TRP GLU TYR GLN ILE LEU VAL PRO          
SEQRES  57 C  742  ARG GLY SER ALA ALA ALA TRP SER HIS PRO GLN PHE GLU          
SEQRES  58 C  742  LYS                                                          
SEQRES   1 D  742  MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU          
SEQRES   2 D  742  CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG          
SEQRES   3 D  742  GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU          
SEQRES   4 D  742  GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA          
SEQRES   5 D  742  ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU          
SEQRES   6 D  742  LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET          
SEQRES   7 D  742  GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN          
SEQRES   8 D  742  LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU          
SEQRES   9 D  742  LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY          
SEQRES  10 D  742  GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET          
SEQRES  11 D  742  ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL          
SEQRES  12 D  742  SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO          
SEQRES  13 D  742  CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE          
SEQRES  14 D  742  ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU          
SEQRES  15 D  742  ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU          
SEQRES  16 D  742  GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN          
SEQRES  17 D  742  LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER          
SEQRES  18 D  742  TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU          
SEQRES  19 D  742  VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA          
SEQRES  20 D  742  GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET          
SEQRES  21 D  742  GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU          
SEQRES  22 D  742  THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER          
SEQRES  23 D  742  GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR          
SEQRES  24 D  742  LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO          
SEQRES  25 D  742  VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY          
SEQRES  26 D  742  ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU          
SEQRES  27 D  742  TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO          
SEQRES  28 D  742  LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP          
SEQRES  29 D  742  ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR          
SEQRES  30 D  742  MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU          
SEQRES  31 D  742  VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU          
SEQRES  32 D  742  VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE          
SEQRES  33 D  742  GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE          
SEQRES  34 D  742  ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET          
SEQRES  35 D  742  ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER          
SEQRES  36 D  742  PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET ALA PHE          
SEQRES  37 D  742  ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET          
SEQRES  38 D  742  ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS          
SEQRES  39 D  742  TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA          
SEQRES  40 D  742  PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU          
SEQRES  41 D  742  GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR          
SEQRES  42 D  742  PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN          
SEQRES  43 D  742  TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR          
SEQRES  44 D  742  ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN          
SEQRES  45 D  742  LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL          
SEQRES  46 D  742  ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL          
SEQRES  47 D  742  ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS          
SEQRES  48 D  742  LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY          
SEQRES  49 D  742  LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN          
SEQRES  50 D  742  ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA          
SEQRES  51 D  742  PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER          
SEQRES  52 D  742  VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS          
SEQRES  53 D  742  LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER          
SEQRES  54 D  742  ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR          
SEQRES  55 D  742  LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU          
SEQRES  56 D  742  GLU ASP GLY GLU SER TRP GLU TYR GLN ILE LEU VAL PRO          
SEQRES  57 D  742  ARG GLY SER ALA ALA ALA TRP SER HIS PRO GLN PHE GLU          
SEQRES  58 D  742  LYS                                                          
HELIX    1 AA1 SER A   28  SER A   47  1                                  20    
HELIX    2 AA2 SER A   47  ALA A   53  1                                   7    
HELIX    3 AA3 ASP A   57  LEU A   65  1                                   9    
HELIX    4 AA4 THR A   81  TYR A   89  1                                   9    
HELIX    5 AA5 ASN A   91  ALA A  102  1                                  12    
HELIX    6 AA6 THR A  119  ASN A  127  1                                   9    
HELIX    7 AA7 ASN A  131  ARG A  139  1                                   9    
HELIX    8 AA8 GLY A  149  ARG A  153  5                                   5    
HELIX    9 AA9 HIS A  165  VAL A  173  1                                   9    
HELIX   10 AB1 SER A  175  GLU A  184  1                                  10    
HELIX   11 AB2 THR A  198  LEU A  205  1                                   8    
HELIX   12 AB3 LYS A  209  LEU A  220  1                                  12    
HELIX   13 AB4 SER A  221  ASP A  223  5                                   3    
HELIX   14 AB5 THR A  242  GLY A  251  1                                  10    
HELIX   15 AB6 ASN A  252  LYS A  264  1                                  13    
HELIX   16 AB7 LEU A  292  THR A  299  1                                   8    
HELIX   17 AB8 LYS A  301  ASP A  309  5                                   9    
HELIX   18 AB9 GLN A  310  ARG A  323  1                                  14    
HELIX   19 AC1 GLY A  325  CYS A  346  1                                  22    
HELIX   20 AC2 PRO A  380  GLU A  403  1                                  24    
HELIX   21 AC3 PHE A  425  ILE A  445  1                                  21    
HELIX   22 AC4 GLU A  450  ASN A  464  1                                  15    
HELIX   23 AC5 MET A  466  PHE A  472  5                                   7    
HELIX   24 AC6 LEU A  475  PHE A  487  1                                  13    
HELIX   25 AC7 PHE A  493  PHE A  512  1                                  20    
HELIX   26 AC8 LEU A  520  TYR A  524  5                                   5    
HELIX   27 AC9 ASP A  525  LEU A  538  1                                  14    
HELIX   28 AD1 PRO A  552  THR A  567  1                                  16    
HELIX   29 AD2 LEU A  568  HIS A  587  1                                  20    
HELIX   30 AD3 GLU A  588  ARG A  606  1                                  19    
HELIX   31 AD4 TRP B   29  SER B   47  1                                  19    
HELIX   32 AD5 SER B   47  ALA B   53  1                                   7    
HELIX   33 AD6 ASP B   57  LEU B   65  1                                   9    
HELIX   34 AD7 THR B   81  TYR B   89  1                                   9    
HELIX   35 AD8 ASN B   91  ALA B  102  1                                  12    
HELIX   36 AD9 THR B  119  ASN B  127  1                                   9    
HELIX   37 AE1 ASN B  131  ARG B  139  1                                   9    
HELIX   38 AE2 GLY B  149  ARG B  153  5                                   5    
HELIX   39 AE3 HIS B  165  VAL B  173  1                                   9    
HELIX   40 AE4 SER B  175  GLU B  184  1                                  10    
HELIX   41 AE5 THR B  198  LEU B  205  1                                   8    
HELIX   42 AE6 LYS B  209  LEU B  220  1                                  12    
HELIX   43 AE7 SER B  221  ASP B  223  5                                   3    
HELIX   44 AE8 THR B  242  GLY B  251  1                                  10    
HELIX   45 AE9 ASN B  252  LYS B  264  1                                  13    
HELIX   46 AF1 LEU B  292  THR B  299  1                                   8    
HELIX   47 AF2 LYS B  301  ASP B  309  5                                   9    
HELIX   48 AF3 GLN B  310  ARG B  323  1                                  14    
HELIX   49 AF4 GLY B  325  CYS B  342  1                                  18    
HELIX   50 AF5 MET B  345  CYS B  346  1                                   2    
HELIX   51 AF6 PRO B  380  GLU B  403  1                                  24    
HELIX   52 AF7 PHE B  425  ILE B  445  1                                  21    
HELIX   53 AF8 GLU B  450  ASN B  464  1                                  15    
HELIX   54 AF9 MET B  466  PHE B  472  5                                   7    
HELIX   55 AG1 LEU B  475  PHE B  487  1                                  13    
HELIX   56 AG2 PHE B  493  PHE B  512  1                                  20    
HELIX   57 AG3 LEU B  520  TYR B  524  5                                   5    
HELIX   58 AG4 ASP B  525  LEU B  538  1                                  14    
HELIX   59 AG5 PRO B  552  THR B  567  1                                  16    
HELIX   60 AG6 LEU B  568  HIS B  587  1                                  20    
HELIX   61 AG7 GLU B  588  ARG B  606  1                                  19    
HELIX   62 AG8 TRP C   29  SER C   47  1                                  19    
HELIX   63 AG9 SER C   47  ALA C   53  1                                   7    
HELIX   64 AH1 ASP C   57  LEU C   65  1                                   9    
HELIX   65 AH2 THR C   81  TYR C   89  1                                   9    
HELIX   66 AH3 ASN C   91  ALA C  102  1                                  12    
HELIX   67 AH4 THR C  119  ASN C  127  1                                   9    
HELIX   68 AH5 ASN C  131  ARG C  139  1                                   9    
HELIX   69 AH6 GLY C  149  ARG C  153  5                                   5    
HELIX   70 AH7 HIS C  165  VAL C  173  1                                   9    
HELIX   71 AH8 SER C  175  GLU C  184  1                                  10    
HELIX   72 AH9 THR C  198  LEU C  205  1                                   8    
HELIX   73 AI1 LYS C  209  LEU C  220  1                                  12    
HELIX   74 AI2 SER C  221  ASP C  223  5                                   3    
HELIX   75 AI3 THR C  242  GLY C  251  1                                  10    
HELIX   76 AI4 ASN C  252  LYS C  264  1                                  13    
HELIX   77 AI5 LEU C  292  THR C  299  1                                   8    
HELIX   78 AI6 LYS C  301  ASP C  309  5                                   9    
HELIX   79 AI7 GLN C  310  ARG C  323  1                                  14    
HELIX   80 AI8 GLY C  325  CYS C  346  1                                  22    
HELIX   81 AI9 PRO C  380  GLU C  403  1                                  24    
HELIX   82 AJ1 PHE C  425  ILE C  445  1                                  21    
HELIX   83 AJ2 GLU C  450  ASN C  464  1                                  15    
HELIX   84 AJ3 MET C  466  PHE C  472  5                                   7    
HELIX   85 AJ4 LEU C  475  PHE C  487  1                                  13    
HELIX   86 AJ5 PHE C  493  PHE C  512  1                                  20    
HELIX   87 AJ6 LEU C  520  TYR C  524  5                                   5    
HELIX   88 AJ7 ASP C  525  LEU C  538  1                                  14    
HELIX   89 AJ8 PRO C  552  THR C  567  1                                  16    
HELIX   90 AJ9 LEU C  568  HIS C  587  1                                  20    
HELIX   91 AK1 GLU C  588  ARG C  606  1                                  19    
HELIX   92 AK2 TRP D   29  SER D   47  1                                  19    
HELIX   93 AK3 SER D   47  ALA D   53  1                                   7    
HELIX   94 AK4 ASP D   57  LEU D   65  1                                   9    
HELIX   95 AK5 THR D   81  TYR D   89  1                                   9    
HELIX   96 AK6 ASN D   91  ALA D  102  1                                  12    
HELIX   97 AK7 THR D  119  ASN D  127  1                                   9    
HELIX   98 AK8 ASN D  131  ARG D  139  1                                   9    
HELIX   99 AK9 GLY D  149  ARG D  153  5                                   5    
HELIX  100 AL1 HIS D  165  VAL D  173  1                                   9    
HELIX  101 AL2 SER D  175  GLU D  184  1                                  10    
HELIX  102 AL3 THR D  198  LEU D  205  1                                   8    
HELIX  103 AL4 LYS D  209  LEU D  220  1                                  12    
HELIX  104 AL5 SER D  221  ASP D  223  5                                   3    
HELIX  105 AL6 THR D  242  GLY D  251  1                                  10    
HELIX  106 AL7 ASN D  252  LYS D  264  1                                  13    
HELIX  107 AL8 LEU D  292  THR D  299  1                                   8    
HELIX  108 AL9 LYS D  301  ASP D  309  5                                   9    
HELIX  109 AM1 GLN D  310  ARG D  323  1                                  14    
HELIX  110 AM2 GLY D  325  CYS D  346  1                                  22    
HELIX  111 AM3 PRO D  380  GLU D  403  1                                  24    
HELIX  112 AM4 PHE D  425  ILE D  445  1                                  21    
HELIX  113 AM5 GLU D  450  ASN D  464  1                                  15    
HELIX  114 AM6 MET D  466  PHE D  472  5                                   7    
HELIX  115 AM7 LEU D  475  PHE D  487  1                                  13    
HELIX  116 AM8 PHE D  493  PHE D  512  1                                  20    
HELIX  117 AM9 LEU D  520  TYR D  524  5                                   5    
HELIX  118 AN1 ASP D  525  LEU D  538  1                                  14    
HELIX  119 AN2 PRO D  552  THR D  567  1                                  16    
HELIX  120 AN3 LEU D  568  HIS D  587  1                                  20    
HELIX  121 AN4 GLU D  588  ARG D  606  1                                  19    
SHEET    1 AA1 2 THR A 269  TYR A 270  0                                        
SHEET    2 AA1 2 LEU A 273  THR A 274 -1  O  LEU A 273   N  TYR A 270           
SHEET    1 AA2 2 THR A 276  TYR A 278  0                                        
SHEET    2 AA2 2 LEU A 631  VAL A 633 -1  O  LEU A 631   N  TYR A 278           
SHEET    1 AA3 2 THR B 269  TYR B 270  0                                        
SHEET    2 AA3 2 LEU B 273  THR B 274 -1  O  LEU B 273   N  TYR B 270           
SHEET    1 AA4 2 THR B 276  TYR B 278  0                                        
SHEET    2 AA4 2 LEU B 631  VAL B 633 -1  O  LEU B 631   N  TYR B 278           
SHEET    1 AA5 2 THR C 269  TYR C 270  0                                        
SHEET    2 AA5 2 LEU C 273  THR C 274 -1  O  LEU C 273   N  TYR C 270           
SHEET    1 AA6 2 THR C 276  TYR C 278  0                                        
SHEET    2 AA6 2 LEU C 631  VAL C 633 -1  O  LEU C 631   N  TYR C 278           
SHEET    1 AA7 2 THR D 269  TYR D 270  0                                        
SHEET    2 AA7 2 LEU D 273  THR D 274 -1  O  LEU D 273   N  TYR D 270           
SHEET    1 AA8 2 THR D 276  TYR D 278  0                                        
SHEET    2 AA8 2 LEU D 631  VAL D 633 -1  O  LEU D 631   N  TYR D 278           
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system