GenomeNet

Database: PDB
Entry: 6DU8
LinkDB: 6DU8
Original site: 6DU8 
HEADER    MEMBRANE PROTEIN                        20-JUN-18   6DU8              
TITLE     HUMAN POLYCSYTIN 2-L1                                                 
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: POLYCYSTIC KIDNEY DISEASE 2-LIKE 1 PROTEIN;                
COMPND   3 CHAIN: A, B, C, D;                                                   
COMPND   4 SYNONYM: POLYCYSTIN-2 HOMOLOG,POLYCYSTIN-2L1,POLYCYSTIN-L,POLYCYSTIN-
COMPND   5 L1;                                                                  
COMPND   6 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: PKD2L1, PKD2L, PKDL, TRPP3;                                    
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   9 EXPRESSION_SYSTEM_CELL_LINE: HEK293S;                                
SOURCE  10 EXPRESSION_SYSTEM_ATCC_NUMBER: CRL-3022;                             
SOURCE  11 EXPRESSION_SYSTEM_CELL: HEK-293S GNTL;                               
SOURCE  12 EXPRESSION_SYSTEM_PLASMID: PEG                                       
KEYWDS    POLYCYSTIC 2-L1, PC2L1, PKD2L1, TRPP2, MEMBRANE PROTEIN               
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    R.E.HULSE,D.E.CLAPHAM,Z.LI,R.K.HUANG,J.ZHANG                          
REVDAT   4   29-JUL-20 6DU8    1       COMPND REMARK HETNAM LINK                
REVDAT   4 2                   1       SITE                                     
REVDAT   3   18-DEC-19 6DU8    1       CRYST1 SCALE                             
REVDAT   2   20-NOV-19 6DU8    1       REMARK                                   
REVDAT   1   25-JUL-18 6DU8    0                                                
JRNL        AUTH   R.E.HULSE,Z.LI,R.K.HUANG,J.ZHANG,D.E.CLAPHAM                 
JRNL        TITL   CRYO-EM STRUCTURE OF THE POLYCYSTIN 2-L1 ION CHANNEL.        
JRNL        REF    ELIFE                         V.   7       2018              
JRNL        REFN                   ESSN 2050-084X                               
JRNL        PMID   30004384                                                     
JRNL        DOI    10.7554/ELIFE.36931                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.11 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.110                          
REMARK   3   NUMBER OF PARTICLES               : 119334                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6DU8 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-JUN-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000233422.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : 3D ARRAY                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : HUMAN POLYCYSTIC 2-L              
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 3.50                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : HOMOTETRAMERIC ASSEMBLY OF        
REMARK 245  POLYCYSTIC 2-L1                                                     
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : OTHER                          
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 60.00                          
REMARK 245   ILLUMINATION MODE                 : OTHER                          
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ASN A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     VAL A     4                                                      
REMARK 465     GLY A     5                                                      
REMARK 465     SER A     6                                                      
REMARK 465     PRO A     7                                                      
REMARK 465     GLU A     8                                                      
REMARK 465     GLY A     9                                                      
REMARK 465     GLN A    10                                                      
REMARK 465     GLU A    11                                                      
REMARK 465     LEU A    12                                                      
REMARK 465     GLN A    13                                                      
REMARK 465     LYS A    14                                                      
REMARK 465     LEU A    15                                                      
REMARK 465     GLY A    16                                                      
REMARK 465     SER A    17                                                      
REMARK 465     GLY A    18                                                      
REMARK 465     ALA A    19                                                      
REMARK 465     TRP A    20                                                      
REMARK 465     ASP A    21                                                      
REMARK 465     ASN A    22                                                      
REMARK 465     PRO A    23                                                      
REMARK 465     ALA A    24                                                      
REMARK 465     TYR A    25                                                      
REMARK 465     SER A    26                                                      
REMARK 465     GLY A    27                                                      
REMARK 465     PRO A    28                                                      
REMARK 465     PRO A    29                                                      
REMARK 465     SER A    30                                                      
REMARK 465     PRO A    31                                                      
REMARK 465     HIS A    32                                                      
REMARK 465     GLY A    33                                                      
REMARK 465     THR A    34                                                      
REMARK 465     LEU A    35                                                      
REMARK 465     ARG A    36                                                      
REMARK 465     VAL A    37                                                      
REMARK 465     CYS A    38                                                      
REMARK 465     THR A    39                                                      
REMARK 465     ILE A    40                                                      
REMARK 465     SER A    41                                                      
REMARK 465     SER A    42                                                      
REMARK 465     THR A    43                                                      
REMARK 465     GLY A    44                                                      
REMARK 465     PRO A    45                                                      
REMARK 465     LEU A    46                                                      
REMARK 465     GLN A    47                                                      
REMARK 465     PRO A    48                                                      
REMARK 465     GLN A    49                                                      
REMARK 465     PRO A    50                                                      
REMARK 465     LYS A    51                                                      
REMARK 465     LYS A    52                                                      
REMARK 465     PRO A    53                                                      
REMARK 465     GLU A    54                                                      
REMARK 465     ASP A    55                                                      
REMARK 465     GLU A    56                                                      
REMARK 465     PRO A    57                                                      
REMARK 465     GLN A    58                                                      
REMARK 465     GLU A    59                                                      
REMARK 465     THR A    60                                                      
REMARK 465     ALA A    61                                                      
REMARK 465     TYR A    62                                                      
REMARK 465     ARG A    63                                                      
REMARK 465     THR A    64                                                      
REMARK 465     GLN A    65                                                      
REMARK 465     VAL A    66                                                      
REMARK 465     SER A    67                                                      
REMARK 465     SER A    68                                                      
REMARK 465     CYS A    69                                                      
REMARK 465     CYS A    70                                                      
REMARK 465     LEU A    71                                                      
REMARK 465     HIS A    72                                                      
REMARK 465     ILE A    73                                                      
REMARK 465     CYS A    74                                                      
REMARK 465     GLN A    75                                                      
REMARK 465     GLY A    76                                                      
REMARK 465     ILE A    77                                                      
REMARK 465     ARG A    78                                                      
REMARK 465     GLY A    79                                                      
REMARK 465     LEU A    80                                                      
REMARK 465     TRP A    81                                                      
REMARK 465     GLY A    82                                                      
REMARK 465     THR A    83                                                      
REMARK 465     THR A    84                                                      
REMARK 465     LEU A    85                                                      
REMARK 465     THR A    86                                                      
REMARK 465     GLU A    87                                                      
REMARK 465     ASN A    88                                                      
REMARK 465     THR A    89                                                      
REMARK 465     ALA A    90                                                      
REMARK 465     GLU A    91                                                      
REMARK 465     ASN A    92                                                      
REMARK 465     ARG A    93                                                      
REMARK 465     GLU A    94                                                      
REMARK 465     LEU A    95                                                      
REMARK 465     TYR A    96                                                      
REMARK 465     ILE A    97                                                      
REMARK 465     LYS A    98                                                      
REMARK 465     THR A    99                                                      
REMARK 465     THR A   100                                                      
REMARK 465     LYS A   173                                                      
REMARK 465     TRP A   174                                                      
REMARK 465     TYR A   175                                                      
REMARK 465     ASN A   176                                                      
REMARK 465     ASN A   177                                                      
REMARK 465     GLN A   178                                                      
REMARK 465     SER A   179                                                      
REMARK 465     LEU A   180                                                      
REMARK 465     TYR A   344                                                      
REMARK 465     VAL A   345                                                      
REMARK 465     SER A   346                                                      
REMARK 465     ASN A   347                                                      
REMARK 465     TRP A   348                                                      
REMARK 465     ASP A   349                                                      
REMARK 465     PHE A   350                                                      
REMARK 465     LEU A   382                                                      
REMARK 465     SER A   383                                                      
REMARK 465     ILE A   457                                                      
REMARK 465     SER A   458                                                      
REMARK 465     PHE A   459                                                      
REMARK 465     ASN A   460                                                      
REMARK 465     LYS A   461                                                      
REMARK 465     THR A   462                                                      
REMARK 465     MET A   463                                                      
REMARK 465     THR A   464                                                      
REMARK 465     GLN A   465                                                      
REMARK 465     LEU A   466                                                      
REMARK 465     SER A   467                                                      
REMARK 465     SER A   468                                                      
REMARK 465     THR A   469                                                      
REMARK 465     LEU A   470                                                      
REMARK 465     ALA A   471                                                      
REMARK 465     ARG A   472                                                      
REMARK 465     CYS A   473                                                      
REMARK 465     ALA A   474                                                      
REMARK 465     LYS A   475                                                      
REMARK 465     ASP A   476                                                      
REMARK 465     ILE A   477                                                      
REMARK 465     LEU A   478                                                      
REMARK 465     GLY A   479                                                      
REMARK 465     ASP A   562                                                      
REMARK 465     THR A   563                                                      
REMARK 465     TYR A   564                                                      
REMARK 465     SER A   565                                                      
REMARK 465     GLU A   566                                                      
REMARK 465     VAL A   567                                                      
REMARK 465     LYS A   568                                                      
REMARK 465     GLU A   569                                                      
REMARK 465     GLU A   570                                                      
REMARK 465     LEU A   571                                                      
REMARK 465     ALA A   572                                                      
REMARK 465     GLY A   573                                                      
REMARK 465     GLN A   574                                                      
REMARK 465     LYS A   575                                                      
REMARK 465     ASP A   576                                                      
REMARK 465     GLU A   577                                                      
REMARK 465     LEU A   578                                                      
REMARK 465     GLN A   579                                                      
REMARK 465     LEU A   580                                                      
REMARK 465     SER A   581                                                      
REMARK 465     ASP A   582                                                      
REMARK 465     LEU A   583                                                      
REMARK 465     LEU A   584                                                      
REMARK 465     LYS A   585                                                      
REMARK 465     GLN A   586                                                      
REMARK 465     GLY A   587                                                      
REMARK 465     TYR A   588                                                      
REMARK 465     ASN A   589                                                      
REMARK 465     LYS A   590                                                      
REMARK 465     THR A   591                                                      
REMARK 465     LEU A   592                                                      
REMARK 465     LEU A   593                                                      
REMARK 465     ARG A   594                                                      
REMARK 465     LEU A   595                                                      
REMARK 465     ARG A   596                                                      
REMARK 465     LEU A   597                                                      
REMARK 465     ARG A   598                                                      
REMARK 465     LYS A   599                                                      
REMARK 465     GLU A   600                                                      
REMARK 465     ARG A   601                                                      
REMARK 465     VAL A   602                                                      
REMARK 465     SER A   603                                                      
REMARK 465     ASP A   604                                                      
REMARK 465     VAL A   605                                                      
REMARK 465     GLN A   606                                                      
REMARK 465     LYS A   607                                                      
REMARK 465     VAL A   608                                                      
REMARK 465     LEU A   609                                                      
REMARK 465     GLN A   610                                                      
REMARK 465     GLY A   611                                                      
REMARK 465     GLY A   612                                                      
REMARK 465     GLU A   613                                                      
REMARK 465     GLN A   614                                                      
REMARK 465     GLU A   615                                                      
REMARK 465     ILE A   616                                                      
REMARK 465     GLN A   617                                                      
REMARK 465     PHE A   618                                                      
REMARK 465     GLU A   619                                                      
REMARK 465     ASP A   620                                                      
REMARK 465     PHE A   621                                                      
REMARK 465     THR A   622                                                      
REMARK 465     ASN A   623                                                      
REMARK 465     THR A   624                                                      
REMARK 465     LEU A   625                                                      
REMARK 465     ARG A   626                                                      
REMARK 465     GLU A   627                                                      
REMARK 465     LEU A   628                                                      
REMARK 465     GLY A   629                                                      
REMARK 465     HIS A   630                                                      
REMARK 465     ALA A   631                                                      
REMARK 465     GLU A   632                                                      
REMARK 465     HIS A   633                                                      
REMARK 465     GLU A   634                                                      
REMARK 465     ILE A   635                                                      
REMARK 465     THR A   636                                                      
REMARK 465     GLU A   637                                                      
REMARK 465     LEU A   638                                                      
REMARK 465     THR A   639                                                      
REMARK 465     ALA A   640                                                      
REMARK 465     THR A   641                                                      
REMARK 465     PHE A   642                                                      
REMARK 465     THR A   643                                                      
REMARK 465     LYS A   644                                                      
REMARK 465     PHE A   645                                                      
REMARK 465     ASP A   646                                                      
REMARK 465     ARG A   647                                                      
REMARK 465     ASP A   648                                                      
REMARK 465     GLY A   649                                                      
REMARK 465     ASN A   650                                                      
REMARK 465     ARG A   651                                                      
REMARK 465     ILE A   652                                                      
REMARK 465     LEU A   653                                                      
REMARK 465     ASP A   654                                                      
REMARK 465     GLU A   655                                                      
REMARK 465     LYS A   656                                                      
REMARK 465     GLU A   657                                                      
REMARK 465     GLN A   658                                                      
REMARK 465     GLU A   659                                                      
REMARK 465     LYS A   660                                                      
REMARK 465     MET A   661                                                      
REMARK 465     ARG A   662                                                      
REMARK 465     GLN A   663                                                      
REMARK 465     ASP A   664                                                      
REMARK 465     LEU A   665                                                      
REMARK 465     GLU A   666                                                      
REMARK 465     GLU A   667                                                      
REMARK 465     GLU A   668                                                      
REMARK 465     ARG A   669                                                      
REMARK 465     VAL A   670                                                      
REMARK 465     ALA A   671                                                      
REMARK 465     LEU A   672                                                      
REMARK 465     ASN A   673                                                      
REMARK 465     THR A   674                                                      
REMARK 465     GLU A   675                                                      
REMARK 465     ILE A   676                                                      
REMARK 465     GLU A   677                                                      
REMARK 465     LYS A   678                                                      
REMARK 465     LEU A   679                                                      
REMARK 465     GLY A   680                                                      
REMARK 465     ARG A   681                                                      
REMARK 465     SER A   682                                                      
REMARK 465     ILE A   683                                                      
REMARK 465     VAL A   684                                                      
REMARK 465     SER A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     PRO A   687                                                      
REMARK 465     GLN A   688                                                      
REMARK 465     GLY A   689                                                      
REMARK 465     LYS A   690                                                      
REMARK 465     SER A   691                                                      
REMARK 465     GLY A   692                                                      
REMARK 465     PRO A   693                                                      
REMARK 465     GLU A   694                                                      
REMARK 465     ALA A   695                                                      
REMARK 465     ALA A   696                                                      
REMARK 465     ARG A   697                                                      
REMARK 465     ALA A   698                                                      
REMARK 465     GLY A   699                                                      
REMARK 465     GLY A   700                                                      
REMARK 465     TRP A   701                                                      
REMARK 465     VAL A   702                                                      
REMARK 465     SER A   703                                                      
REMARK 465     GLY A   704                                                      
REMARK 465     GLU A   705                                                      
REMARK 465     GLU A   706                                                      
REMARK 465     PHE A   707                                                      
REMARK 465     TYR A   708                                                      
REMARK 465     MET A   709                                                      
REMARK 465     LEU A   710                                                      
REMARK 465     THR A   711                                                      
REMARK 465     ARG A   712                                                      
REMARK 465     ARG A   713                                                      
REMARK 465     VAL A   714                                                      
REMARK 465     LEU A   715                                                      
REMARK 465     GLN A   716                                                      
REMARK 465     LEU A   717                                                      
REMARK 465     GLU A   718                                                      
REMARK 465     THR A   719                                                      
REMARK 465     VAL A   720                                                      
REMARK 465     LEU A   721                                                      
REMARK 465     GLU A   722                                                      
REMARK 465     GLY A   723                                                      
REMARK 465     VAL A   724                                                      
REMARK 465     VAL A   725                                                      
REMARK 465     SER A   726                                                      
REMARK 465     GLN A   727                                                      
REMARK 465     ILE A   728                                                      
REMARK 465     ASP A   729                                                      
REMARK 465     ALA A   730                                                      
REMARK 465     VAL A   731                                                      
REMARK 465     GLY A   732                                                      
REMARK 465     SER A   733                                                      
REMARK 465     LYS A   734                                                      
REMARK 465     LEU A   735                                                      
REMARK 465     LYS A   736                                                      
REMARK 465     MET A   737                                                      
REMARK 465     LEU A   738                                                      
REMARK 465     GLU A   739                                                      
REMARK 465     ARG A   740                                                      
REMARK 465     LYS A   741                                                      
REMARK 465     GLY A   742                                                      
REMARK 465     TRP A   743                                                      
REMARK 465     LEU A   744                                                      
REMARK 465     ALA A   745                                                      
REMARK 465     PRO A   746                                                      
REMARK 465     SER A   747                                                      
REMARK 465     PRO A   748                                                      
REMARK 465     GLY A   749                                                      
REMARK 465     VAL A   750                                                      
REMARK 465     LYS A   751                                                      
REMARK 465     GLU A   752                                                      
REMARK 465     GLN A   753                                                      
REMARK 465     ALA A   754                                                      
REMARK 465     ILE A   755                                                      
REMARK 465     TRP A   756                                                      
REMARK 465     LYS A   757                                                      
REMARK 465     HIS A   758                                                      
REMARK 465     PRO A   759                                                      
REMARK 465     GLN A   760                                                      
REMARK 465     PRO A   761                                                      
REMARK 465     ALA A   762                                                      
REMARK 465     PRO A   763                                                      
REMARK 465     ALA A   764                                                      
REMARK 465     VAL A   765                                                      
REMARK 465     THR A   766                                                      
REMARK 465     PRO A   767                                                      
REMARK 465     ASP A   768                                                      
REMARK 465     PRO A   769                                                      
REMARK 465     TRP A   770                                                      
REMARK 465     GLY A   771                                                      
REMARK 465     VAL A   772                                                      
REMARK 465     GLN A   773                                                      
REMARK 465     GLY A   774                                                      
REMARK 465     GLY A   775                                                      
REMARK 465     GLN A   776                                                      
REMARK 465     GLU A   777                                                      
REMARK 465     SER A   778                                                      
REMARK 465     GLU A   779                                                      
REMARK 465     VAL A   780                                                      
REMARK 465     PRO A   781                                                      
REMARK 465     TYR A   782                                                      
REMARK 465     LYS A   783                                                      
REMARK 465     ARG A   784                                                      
REMARK 465     GLU A   785                                                      
REMARK 465     GLU A   786                                                      
REMARK 465     GLU A   787                                                      
REMARK 465     ALA A   788                                                      
REMARK 465     LEU A   789                                                      
REMARK 465     GLU A   790                                                      
REMARK 465     GLU A   791                                                      
REMARK 465     ARG A   792                                                      
REMARK 465     ARG A   793                                                      
REMARK 465     LEU A   794                                                      
REMARK 465     SER A   795                                                      
REMARK 465     ARG A   796                                                      
REMARK 465     GLY A   797                                                      
REMARK 465     GLU A   798                                                      
REMARK 465     ILE A   799                                                      
REMARK 465     PRO A   800                                                      
REMARK 465     THR A   801                                                      
REMARK 465     LEU A   802                                                      
REMARK 465     GLN A   803                                                      
REMARK 465     ARG A   804                                                      
REMARK 465     SER A   805                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ASN B     2                                                      
REMARK 465     ALA B     3                                                      
REMARK 465     VAL B     4                                                      
REMARK 465     GLY B     5                                                      
REMARK 465     SER B     6                                                      
REMARK 465     PRO B     7                                                      
REMARK 465     GLU B     8                                                      
REMARK 465     GLY B     9                                                      
REMARK 465     GLN B    10                                                      
REMARK 465     GLU B    11                                                      
REMARK 465     LEU B    12                                                      
REMARK 465     GLN B    13                                                      
REMARK 465     LYS B    14                                                      
REMARK 465     LEU B    15                                                      
REMARK 465     GLY B    16                                                      
REMARK 465     SER B    17                                                      
REMARK 465     GLY B    18                                                      
REMARK 465     ALA B    19                                                      
REMARK 465     TRP B    20                                                      
REMARK 465     ASP B    21                                                      
REMARK 465     ASN B    22                                                      
REMARK 465     PRO B    23                                                      
REMARK 465     ALA B    24                                                      
REMARK 465     TYR B    25                                                      
REMARK 465     SER B    26                                                      
REMARK 465     GLY B    27                                                      
REMARK 465     PRO B    28                                                      
REMARK 465     PRO B    29                                                      
REMARK 465     SER B    30                                                      
REMARK 465     PRO B    31                                                      
REMARK 465     HIS B    32                                                      
REMARK 465     GLY B    33                                                      
REMARK 465     THR B    34                                                      
REMARK 465     LEU B    35                                                      
REMARK 465     ARG B    36                                                      
REMARK 465     VAL B    37                                                      
REMARK 465     CYS B    38                                                      
REMARK 465     THR B    39                                                      
REMARK 465     ILE B    40                                                      
REMARK 465     SER B    41                                                      
REMARK 465     SER B    42                                                      
REMARK 465     THR B    43                                                      
REMARK 465     GLY B    44                                                      
REMARK 465     PRO B    45                                                      
REMARK 465     LEU B    46                                                      
REMARK 465     GLN B    47                                                      
REMARK 465     PRO B    48                                                      
REMARK 465     GLN B    49                                                      
REMARK 465     PRO B    50                                                      
REMARK 465     LYS B    51                                                      
REMARK 465     LYS B    52                                                      
REMARK 465     PRO B    53                                                      
REMARK 465     GLU B    54                                                      
REMARK 465     ASP B    55                                                      
REMARK 465     GLU B    56                                                      
REMARK 465     PRO B    57                                                      
REMARK 465     GLN B    58                                                      
REMARK 465     GLU B    59                                                      
REMARK 465     THR B    60                                                      
REMARK 465     ALA B    61                                                      
REMARK 465     TYR B    62                                                      
REMARK 465     ARG B    63                                                      
REMARK 465     THR B    64                                                      
REMARK 465     GLN B    65                                                      
REMARK 465     VAL B    66                                                      
REMARK 465     SER B    67                                                      
REMARK 465     SER B    68                                                      
REMARK 465     CYS B    69                                                      
REMARK 465     CYS B    70                                                      
REMARK 465     LEU B    71                                                      
REMARK 465     HIS B    72                                                      
REMARK 465     ILE B    73                                                      
REMARK 465     CYS B    74                                                      
REMARK 465     GLN B    75                                                      
REMARK 465     GLY B    76                                                      
REMARK 465     ILE B    77                                                      
REMARK 465     ARG B    78                                                      
REMARK 465     GLY B    79                                                      
REMARK 465     LEU B    80                                                      
REMARK 465     TRP B    81                                                      
REMARK 465     GLY B    82                                                      
REMARK 465     THR B    83                                                      
REMARK 465     THR B    84                                                      
REMARK 465     LEU B    85                                                      
REMARK 465     THR B    86                                                      
REMARK 465     GLU B    87                                                      
REMARK 465     ASN B    88                                                      
REMARK 465     THR B    89                                                      
REMARK 465     ALA B    90                                                      
REMARK 465     GLU B    91                                                      
REMARK 465     ASN B    92                                                      
REMARK 465     ARG B    93                                                      
REMARK 465     GLU B    94                                                      
REMARK 465     LEU B    95                                                      
REMARK 465     TYR B    96                                                      
REMARK 465     ILE B    97                                                      
REMARK 465     LYS B    98                                                      
REMARK 465     THR B    99                                                      
REMARK 465     THR B   100                                                      
REMARK 465     LYS B   173                                                      
REMARK 465     TRP B   174                                                      
REMARK 465     TYR B   175                                                      
REMARK 465     ASN B   176                                                      
REMARK 465     ASN B   177                                                      
REMARK 465     GLN B   178                                                      
REMARK 465     SER B   179                                                      
REMARK 465     LEU B   180                                                      
REMARK 465     TYR B   344                                                      
REMARK 465     VAL B   345                                                      
REMARK 465     SER B   346                                                      
REMARK 465     ASN B   347                                                      
REMARK 465     TRP B   348                                                      
REMARK 465     ASP B   349                                                      
REMARK 465     PHE B   350                                                      
REMARK 465     LEU B   382                                                      
REMARK 465     SER B   383                                                      
REMARK 465     ILE B   457                                                      
REMARK 465     SER B   458                                                      
REMARK 465     PHE B   459                                                      
REMARK 465     ASN B   460                                                      
REMARK 465     LYS B   461                                                      
REMARK 465     THR B   462                                                      
REMARK 465     MET B   463                                                      
REMARK 465     THR B   464                                                      
REMARK 465     GLN B   465                                                      
REMARK 465     LEU B   466                                                      
REMARK 465     SER B   467                                                      
REMARK 465     SER B   468                                                      
REMARK 465     THR B   469                                                      
REMARK 465     LEU B   470                                                      
REMARK 465     ALA B   471                                                      
REMARK 465     ARG B   472                                                      
REMARK 465     CYS B   473                                                      
REMARK 465     ALA B   474                                                      
REMARK 465     LYS B   475                                                      
REMARK 465     ASP B   476                                                      
REMARK 465     ILE B   477                                                      
REMARK 465     LEU B   478                                                      
REMARK 465     GLY B   479                                                      
REMARK 465     ASP B   562                                                      
REMARK 465     THR B   563                                                      
REMARK 465     TYR B   564                                                      
REMARK 465     SER B   565                                                      
REMARK 465     GLU B   566                                                      
REMARK 465     VAL B   567                                                      
REMARK 465     LYS B   568                                                      
REMARK 465     GLU B   569                                                      
REMARK 465     GLU B   570                                                      
REMARK 465     LEU B   571                                                      
REMARK 465     ALA B   572                                                      
REMARK 465     GLY B   573                                                      
REMARK 465     GLN B   574                                                      
REMARK 465     LYS B   575                                                      
REMARK 465     ASP B   576                                                      
REMARK 465     GLU B   577                                                      
REMARK 465     LEU B   578                                                      
REMARK 465     GLN B   579                                                      
REMARK 465     LEU B   580                                                      
REMARK 465     SER B   581                                                      
REMARK 465     ASP B   582                                                      
REMARK 465     LEU B   583                                                      
REMARK 465     LEU B   584                                                      
REMARK 465     LYS B   585                                                      
REMARK 465     GLN B   586                                                      
REMARK 465     GLY B   587                                                      
REMARK 465     TYR B   588                                                      
REMARK 465     ASN B   589                                                      
REMARK 465     LYS B   590                                                      
REMARK 465     THR B   591                                                      
REMARK 465     LEU B   592                                                      
REMARK 465     LEU B   593                                                      
REMARK 465     ARG B   594                                                      
REMARK 465     LEU B   595                                                      
REMARK 465     ARG B   596                                                      
REMARK 465     LEU B   597                                                      
REMARK 465     ARG B   598                                                      
REMARK 465     LYS B   599                                                      
REMARK 465     GLU B   600                                                      
REMARK 465     ARG B   601                                                      
REMARK 465     VAL B   602                                                      
REMARK 465     SER B   603                                                      
REMARK 465     ASP B   604                                                      
REMARK 465     VAL B   605                                                      
REMARK 465     GLN B   606                                                      
REMARK 465     LYS B   607                                                      
REMARK 465     VAL B   608                                                      
REMARK 465     LEU B   609                                                      
REMARK 465     GLN B   610                                                      
REMARK 465     GLY B   611                                                      
REMARK 465     GLY B   612                                                      
REMARK 465     GLU B   613                                                      
REMARK 465     GLN B   614                                                      
REMARK 465     GLU B   615                                                      
REMARK 465     ILE B   616                                                      
REMARK 465     GLN B   617                                                      
REMARK 465     PHE B   618                                                      
REMARK 465     GLU B   619                                                      
REMARK 465     ASP B   620                                                      
REMARK 465     PHE B   621                                                      
REMARK 465     THR B   622                                                      
REMARK 465     ASN B   623                                                      
REMARK 465     THR B   624                                                      
REMARK 465     LEU B   625                                                      
REMARK 465     ARG B   626                                                      
REMARK 465     GLU B   627                                                      
REMARK 465     LEU B   628                                                      
REMARK 465     GLY B   629                                                      
REMARK 465     HIS B   630                                                      
REMARK 465     ALA B   631                                                      
REMARK 465     GLU B   632                                                      
REMARK 465     HIS B   633                                                      
REMARK 465     GLU B   634                                                      
REMARK 465     ILE B   635                                                      
REMARK 465     THR B   636                                                      
REMARK 465     GLU B   637                                                      
REMARK 465     LEU B   638                                                      
REMARK 465     THR B   639                                                      
REMARK 465     ALA B   640                                                      
REMARK 465     THR B   641                                                      
REMARK 465     PHE B   642                                                      
REMARK 465     THR B   643                                                      
REMARK 465     LYS B   644                                                      
REMARK 465     PHE B   645                                                      
REMARK 465     ASP B   646                                                      
REMARK 465     ARG B   647                                                      
REMARK 465     ASP B   648                                                      
REMARK 465     GLY B   649                                                      
REMARK 465     ASN B   650                                                      
REMARK 465     ARG B   651                                                      
REMARK 465     ILE B   652                                                      
REMARK 465     LEU B   653                                                      
REMARK 465     ASP B   654                                                      
REMARK 465     GLU B   655                                                      
REMARK 465     LYS B   656                                                      
REMARK 465     GLU B   657                                                      
REMARK 465     GLN B   658                                                      
REMARK 465     GLU B   659                                                      
REMARK 465     LYS B   660                                                      
REMARK 465     MET B   661                                                      
REMARK 465     ARG B   662                                                      
REMARK 465     GLN B   663                                                      
REMARK 465     ASP B   664                                                      
REMARK 465     LEU B   665                                                      
REMARK 465     GLU B   666                                                      
REMARK 465     GLU B   667                                                      
REMARK 465     GLU B   668                                                      
REMARK 465     ARG B   669                                                      
REMARK 465     VAL B   670                                                      
REMARK 465     ALA B   671                                                      
REMARK 465     LEU B   672                                                      
REMARK 465     ASN B   673                                                      
REMARK 465     THR B   674                                                      
REMARK 465     GLU B   675                                                      
REMARK 465     ILE B   676                                                      
REMARK 465     GLU B   677                                                      
REMARK 465     LYS B   678                                                      
REMARK 465     LEU B   679                                                      
REMARK 465     GLY B   680                                                      
REMARK 465     ARG B   681                                                      
REMARK 465     SER B   682                                                      
REMARK 465     ILE B   683                                                      
REMARK 465     VAL B   684                                                      
REMARK 465     SER B   685                                                      
REMARK 465     SER B   686                                                      
REMARK 465     PRO B   687                                                      
REMARK 465     GLN B   688                                                      
REMARK 465     GLY B   689                                                      
REMARK 465     LYS B   690                                                      
REMARK 465     SER B   691                                                      
REMARK 465     GLY B   692                                                      
REMARK 465     PRO B   693                                                      
REMARK 465     GLU B   694                                                      
REMARK 465     ALA B   695                                                      
REMARK 465     ALA B   696                                                      
REMARK 465     ARG B   697                                                      
REMARK 465     ALA B   698                                                      
REMARK 465     GLY B   699                                                      
REMARK 465     GLY B   700                                                      
REMARK 465     TRP B   701                                                      
REMARK 465     VAL B   702                                                      
REMARK 465     SER B   703                                                      
REMARK 465     GLY B   704                                                      
REMARK 465     GLU B   705                                                      
REMARK 465     GLU B   706                                                      
REMARK 465     PHE B   707                                                      
REMARK 465     TYR B   708                                                      
REMARK 465     MET B   709                                                      
REMARK 465     LEU B   710                                                      
REMARK 465     THR B   711                                                      
REMARK 465     ARG B   712                                                      
REMARK 465     ARG B   713                                                      
REMARK 465     VAL B   714                                                      
REMARK 465     LEU B   715                                                      
REMARK 465     GLN B   716                                                      
REMARK 465     LEU B   717                                                      
REMARK 465     GLU B   718                                                      
REMARK 465     THR B   719                                                      
REMARK 465     VAL B   720                                                      
REMARK 465     LEU B   721                                                      
REMARK 465     GLU B   722                                                      
REMARK 465     GLY B   723                                                      
REMARK 465     VAL B   724                                                      
REMARK 465     VAL B   725                                                      
REMARK 465     SER B   726                                                      
REMARK 465     GLN B   727                                                      
REMARK 465     ILE B   728                                                      
REMARK 465     ASP B   729                                                      
REMARK 465     ALA B   730                                                      
REMARK 465     VAL B   731                                                      
REMARK 465     GLY B   732                                                      
REMARK 465     SER B   733                                                      
REMARK 465     LYS B   734                                                      
REMARK 465     LEU B   735                                                      
REMARK 465     LYS B   736                                                      
REMARK 465     MET B   737                                                      
REMARK 465     LEU B   738                                                      
REMARK 465     GLU B   739                                                      
REMARK 465     ARG B   740                                                      
REMARK 465     LYS B   741                                                      
REMARK 465     GLY B   742                                                      
REMARK 465     TRP B   743                                                      
REMARK 465     LEU B   744                                                      
REMARK 465     ALA B   745                                                      
REMARK 465     PRO B   746                                                      
REMARK 465     SER B   747                                                      
REMARK 465     PRO B   748                                                      
REMARK 465     GLY B   749                                                      
REMARK 465     VAL B   750                                                      
REMARK 465     LYS B   751                                                      
REMARK 465     GLU B   752                                                      
REMARK 465     GLN B   753                                                      
REMARK 465     ALA B   754                                                      
REMARK 465     ILE B   755                                                      
REMARK 465     TRP B   756                                                      
REMARK 465     LYS B   757                                                      
REMARK 465     HIS B   758                                                      
REMARK 465     PRO B   759                                                      
REMARK 465     GLN B   760                                                      
REMARK 465     PRO B   761                                                      
REMARK 465     ALA B   762                                                      
REMARK 465     PRO B   763                                                      
REMARK 465     ALA B   764                                                      
REMARK 465     VAL B   765                                                      
REMARK 465     THR B   766                                                      
REMARK 465     PRO B   767                                                      
REMARK 465     ASP B   768                                                      
REMARK 465     PRO B   769                                                      
REMARK 465     TRP B   770                                                      
REMARK 465     GLY B   771                                                      
REMARK 465     VAL B   772                                                      
REMARK 465     GLN B   773                                                      
REMARK 465     GLY B   774                                                      
REMARK 465     GLY B   775                                                      
REMARK 465     GLN B   776                                                      
REMARK 465     GLU B   777                                                      
REMARK 465     SER B   778                                                      
REMARK 465     GLU B   779                                                      
REMARK 465     VAL B   780                                                      
REMARK 465     PRO B   781                                                      
REMARK 465     TYR B   782                                                      
REMARK 465     LYS B   783                                                      
REMARK 465     ARG B   784                                                      
REMARK 465     GLU B   785                                                      
REMARK 465     GLU B   786                                                      
REMARK 465     GLU B   787                                                      
REMARK 465     ALA B   788                                                      
REMARK 465     LEU B   789                                                      
REMARK 465     GLU B   790                                                      
REMARK 465     GLU B   791                                                      
REMARK 465     ARG B   792                                                      
REMARK 465     ARG B   793                                                      
REMARK 465     LEU B   794                                                      
REMARK 465     SER B   795                                                      
REMARK 465     ARG B   796                                                      
REMARK 465     GLY B   797                                                      
REMARK 465     GLU B   798                                                      
REMARK 465     ILE B   799                                                      
REMARK 465     PRO B   800                                                      
REMARK 465     THR B   801                                                      
REMARK 465     LEU B   802                                                      
REMARK 465     GLN B   803                                                      
REMARK 465     ARG B   804                                                      
REMARK 465     SER B   805                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ASN C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     VAL C     4                                                      
REMARK 465     GLY C     5                                                      
REMARK 465     SER C     6                                                      
REMARK 465     PRO C     7                                                      
REMARK 465     GLU C     8                                                      
REMARK 465     GLY C     9                                                      
REMARK 465     GLN C    10                                                      
REMARK 465     GLU C    11                                                      
REMARK 465     LEU C    12                                                      
REMARK 465     GLN C    13                                                      
REMARK 465     LYS C    14                                                      
REMARK 465     LEU C    15                                                      
REMARK 465     GLY C    16                                                      
REMARK 465     SER C    17                                                      
REMARK 465     GLY C    18                                                      
REMARK 465     ALA C    19                                                      
REMARK 465     TRP C    20                                                      
REMARK 465     ASP C    21                                                      
REMARK 465     ASN C    22                                                      
REMARK 465     PRO C    23                                                      
REMARK 465     ALA C    24                                                      
REMARK 465     TYR C    25                                                      
REMARK 465     SER C    26                                                      
REMARK 465     GLY C    27                                                      
REMARK 465     PRO C    28                                                      
REMARK 465     PRO C    29                                                      
REMARK 465     SER C    30                                                      
REMARK 465     PRO C    31                                                      
REMARK 465     HIS C    32                                                      
REMARK 465     GLY C    33                                                      
REMARK 465     THR C    34                                                      
REMARK 465     LEU C    35                                                      
REMARK 465     ARG C    36                                                      
REMARK 465     VAL C    37                                                      
REMARK 465     CYS C    38                                                      
REMARK 465     THR C    39                                                      
REMARK 465     ILE C    40                                                      
REMARK 465     SER C    41                                                      
REMARK 465     SER C    42                                                      
REMARK 465     THR C    43                                                      
REMARK 465     GLY C    44                                                      
REMARK 465     PRO C    45                                                      
REMARK 465     LEU C    46                                                      
REMARK 465     GLN C    47                                                      
REMARK 465     PRO C    48                                                      
REMARK 465     GLN C    49                                                      
REMARK 465     PRO C    50                                                      
REMARK 465     LYS C    51                                                      
REMARK 465     LYS C    52                                                      
REMARK 465     PRO C    53                                                      
REMARK 465     GLU C    54                                                      
REMARK 465     ASP C    55                                                      
REMARK 465     GLU C    56                                                      
REMARK 465     PRO C    57                                                      
REMARK 465     GLN C    58                                                      
REMARK 465     GLU C    59                                                      
REMARK 465     THR C    60                                                      
REMARK 465     ALA C    61                                                      
REMARK 465     TYR C    62                                                      
REMARK 465     ARG C    63                                                      
REMARK 465     THR C    64                                                      
REMARK 465     GLN C    65                                                      
REMARK 465     VAL C    66                                                      
REMARK 465     SER C    67                                                      
REMARK 465     SER C    68                                                      
REMARK 465     CYS C    69                                                      
REMARK 465     CYS C    70                                                      
REMARK 465     LEU C    71                                                      
REMARK 465     HIS C    72                                                      
REMARK 465     ILE C    73                                                      
REMARK 465     CYS C    74                                                      
REMARK 465     GLN C    75                                                      
REMARK 465     GLY C    76                                                      
REMARK 465     ILE C    77                                                      
REMARK 465     ARG C    78                                                      
REMARK 465     GLY C    79                                                      
REMARK 465     LEU C    80                                                      
REMARK 465     TRP C    81                                                      
REMARK 465     GLY C    82                                                      
REMARK 465     THR C    83                                                      
REMARK 465     THR C    84                                                      
REMARK 465     LEU C    85                                                      
REMARK 465     THR C    86                                                      
REMARK 465     GLU C    87                                                      
REMARK 465     ASN C    88                                                      
REMARK 465     THR C    89                                                      
REMARK 465     ALA C    90                                                      
REMARK 465     GLU C    91                                                      
REMARK 465     ASN C    92                                                      
REMARK 465     ARG C    93                                                      
REMARK 465     GLU C    94                                                      
REMARK 465     LEU C    95                                                      
REMARK 465     TYR C    96                                                      
REMARK 465     ILE C    97                                                      
REMARK 465     LYS C    98                                                      
REMARK 465     THR C    99                                                      
REMARK 465     THR C   100                                                      
REMARK 465     LYS C   173                                                      
REMARK 465     TRP C   174                                                      
REMARK 465     TYR C   175                                                      
REMARK 465     ASN C   176                                                      
REMARK 465     ASN C   177                                                      
REMARK 465     GLN C   178                                                      
REMARK 465     SER C   179                                                      
REMARK 465     LEU C   180                                                      
REMARK 465     TYR C   344                                                      
REMARK 465     VAL C   345                                                      
REMARK 465     SER C   346                                                      
REMARK 465     ASN C   347                                                      
REMARK 465     TRP C   348                                                      
REMARK 465     ASP C   349                                                      
REMARK 465     PHE C   350                                                      
REMARK 465     LEU C   382                                                      
REMARK 465     SER C   383                                                      
REMARK 465     ILE C   457                                                      
REMARK 465     SER C   458                                                      
REMARK 465     PHE C   459                                                      
REMARK 465     ASN C   460                                                      
REMARK 465     LYS C   461                                                      
REMARK 465     THR C   462                                                      
REMARK 465     MET C   463                                                      
REMARK 465     THR C   464                                                      
REMARK 465     GLN C   465                                                      
REMARK 465     LEU C   466                                                      
REMARK 465     SER C   467                                                      
REMARK 465     SER C   468                                                      
REMARK 465     THR C   469                                                      
REMARK 465     LEU C   470                                                      
REMARK 465     ALA C   471                                                      
REMARK 465     ARG C   472                                                      
REMARK 465     CYS C   473                                                      
REMARK 465     ALA C   474                                                      
REMARK 465     LYS C   475                                                      
REMARK 465     ASP C   476                                                      
REMARK 465     ILE C   477                                                      
REMARK 465     LEU C   478                                                      
REMARK 465     GLY C   479                                                      
REMARK 465     ASP C   562                                                      
REMARK 465     THR C   563                                                      
REMARK 465     TYR C   564                                                      
REMARK 465     SER C   565                                                      
REMARK 465     GLU C   566                                                      
REMARK 465     VAL C   567                                                      
REMARK 465     LYS C   568                                                      
REMARK 465     GLU C   569                                                      
REMARK 465     GLU C   570                                                      
REMARK 465     LEU C   571                                                      
REMARK 465     ALA C   572                                                      
REMARK 465     GLY C   573                                                      
REMARK 465     GLN C   574                                                      
REMARK 465     LYS C   575                                                      
REMARK 465     ASP C   576                                                      
REMARK 465     GLU C   577                                                      
REMARK 465     LEU C   578                                                      
REMARK 465     GLN C   579                                                      
REMARK 465     LEU C   580                                                      
REMARK 465     SER C   581                                                      
REMARK 465     ASP C   582                                                      
REMARK 465     LEU C   583                                                      
REMARK 465     LEU C   584                                                      
REMARK 465     LYS C   585                                                      
REMARK 465     GLN C   586                                                      
REMARK 465     GLY C   587                                                      
REMARK 465     TYR C   588                                                      
REMARK 465     ASN C   589                                                      
REMARK 465     LYS C   590                                                      
REMARK 465     THR C   591                                                      
REMARK 465     LEU C   592                                                      
REMARK 465     LEU C   593                                                      
REMARK 465     ARG C   594                                                      
REMARK 465     LEU C   595                                                      
REMARK 465     ARG C   596                                                      
REMARK 465     LEU C   597                                                      
REMARK 465     ARG C   598                                                      
REMARK 465     LYS C   599                                                      
REMARK 465     GLU C   600                                                      
REMARK 465     ARG C   601                                                      
REMARK 465     VAL C   602                                                      
REMARK 465     SER C   603                                                      
REMARK 465     ASP C   604                                                      
REMARK 465     VAL C   605                                                      
REMARK 465     GLN C   606                                                      
REMARK 465     LYS C   607                                                      
REMARK 465     VAL C   608                                                      
REMARK 465     LEU C   609                                                      
REMARK 465     GLN C   610                                                      
REMARK 465     GLY C   611                                                      
REMARK 465     GLY C   612                                                      
REMARK 465     GLU C   613                                                      
REMARK 465     GLN C   614                                                      
REMARK 465     GLU C   615                                                      
REMARK 465     ILE C   616                                                      
REMARK 465     GLN C   617                                                      
REMARK 465     PHE C   618                                                      
REMARK 465     GLU C   619                                                      
REMARK 465     ASP C   620                                                      
REMARK 465     PHE C   621                                                      
REMARK 465     THR C   622                                                      
REMARK 465     ASN C   623                                                      
REMARK 465     THR C   624                                                      
REMARK 465     LEU C   625                                                      
REMARK 465     ARG C   626                                                      
REMARK 465     GLU C   627                                                      
REMARK 465     LEU C   628                                                      
REMARK 465     GLY C   629                                                      
REMARK 465     HIS C   630                                                      
REMARK 465     ALA C   631                                                      
REMARK 465     GLU C   632                                                      
REMARK 465     HIS C   633                                                      
REMARK 465     GLU C   634                                                      
REMARK 465     ILE C   635                                                      
REMARK 465     THR C   636                                                      
REMARK 465     GLU C   637                                                      
REMARK 465     LEU C   638                                                      
REMARK 465     THR C   639                                                      
REMARK 465     ALA C   640                                                      
REMARK 465     THR C   641                                                      
REMARK 465     PHE C   642                                                      
REMARK 465     THR C   643                                                      
REMARK 465     LYS C   644                                                      
REMARK 465     PHE C   645                                                      
REMARK 465     ASP C   646                                                      
REMARK 465     ARG C   647                                                      
REMARK 465     ASP C   648                                                      
REMARK 465     GLY C   649                                                      
REMARK 465     ASN C   650                                                      
REMARK 465     ARG C   651                                                      
REMARK 465     ILE C   652                                                      
REMARK 465     LEU C   653                                                      
REMARK 465     ASP C   654                                                      
REMARK 465     GLU C   655                                                      
REMARK 465     LYS C   656                                                      
REMARK 465     GLU C   657                                                      
REMARK 465     GLN C   658                                                      
REMARK 465     GLU C   659                                                      
REMARK 465     LYS C   660                                                      
REMARK 465     MET C   661                                                      
REMARK 465     ARG C   662                                                      
REMARK 465     GLN C   663                                                      
REMARK 465     ASP C   664                                                      
REMARK 465     LEU C   665                                                      
REMARK 465     GLU C   666                                                      
REMARK 465     GLU C   667                                                      
REMARK 465     GLU C   668                                                      
REMARK 465     ARG C   669                                                      
REMARK 465     VAL C   670                                                      
REMARK 465     ALA C   671                                                      
REMARK 465     LEU C   672                                                      
REMARK 465     ASN C   673                                                      
REMARK 465     THR C   674                                                      
REMARK 465     GLU C   675                                                      
REMARK 465     ILE C   676                                                      
REMARK 465     GLU C   677                                                      
REMARK 465     LYS C   678                                                      
REMARK 465     LEU C   679                                                      
REMARK 465     GLY C   680                                                      
REMARK 465     ARG C   681                                                      
REMARK 465     SER C   682                                                      
REMARK 465     ILE C   683                                                      
REMARK 465     VAL C   684                                                      
REMARK 465     SER C   685                                                      
REMARK 465     SER C   686                                                      
REMARK 465     PRO C   687                                                      
REMARK 465     GLN C   688                                                      
REMARK 465     GLY C   689                                                      
REMARK 465     LYS C   690                                                      
REMARK 465     SER C   691                                                      
REMARK 465     GLY C   692                                                      
REMARK 465     PRO C   693                                                      
REMARK 465     GLU C   694                                                      
REMARK 465     ALA C   695                                                      
REMARK 465     ALA C   696                                                      
REMARK 465     ARG C   697                                                      
REMARK 465     ALA C   698                                                      
REMARK 465     GLY C   699                                                      
REMARK 465     GLY C   700                                                      
REMARK 465     TRP C   701                                                      
REMARK 465     VAL C   702                                                      
REMARK 465     SER C   703                                                      
REMARK 465     GLY C   704                                                      
REMARK 465     GLU C   705                                                      
REMARK 465     GLU C   706                                                      
REMARK 465     PHE C   707                                                      
REMARK 465     TYR C   708                                                      
REMARK 465     MET C   709                                                      
REMARK 465     LEU C   710                                                      
REMARK 465     THR C   711                                                      
REMARK 465     ARG C   712                                                      
REMARK 465     ARG C   713                                                      
REMARK 465     VAL C   714                                                      
REMARK 465     LEU C   715                                                      
REMARK 465     GLN C   716                                                      
REMARK 465     LEU C   717                                                      
REMARK 465     GLU C   718                                                      
REMARK 465     THR C   719                                                      
REMARK 465     VAL C   720                                                      
REMARK 465     LEU C   721                                                      
REMARK 465     GLU C   722                                                      
REMARK 465     GLY C   723                                                      
REMARK 465     VAL C   724                                                      
REMARK 465     VAL C   725                                                      
REMARK 465     SER C   726                                                      
REMARK 465     GLN C   727                                                      
REMARK 465     ILE C   728                                                      
REMARK 465     ASP C   729                                                      
REMARK 465     ALA C   730                                                      
REMARK 465     VAL C   731                                                      
REMARK 465     GLY C   732                                                      
REMARK 465     SER C   733                                                      
REMARK 465     LYS C   734                                                      
REMARK 465     LEU C   735                                                      
REMARK 465     LYS C   736                                                      
REMARK 465     MET C   737                                                      
REMARK 465     LEU C   738                                                      
REMARK 465     GLU C   739                                                      
REMARK 465     ARG C   740                                                      
REMARK 465     LYS C   741                                                      
REMARK 465     GLY C   742                                                      
REMARK 465     TRP C   743                                                      
REMARK 465     LEU C   744                                                      
REMARK 465     ALA C   745                                                      
REMARK 465     PRO C   746                                                      
REMARK 465     SER C   747                                                      
REMARK 465     PRO C   748                                                      
REMARK 465     GLY C   749                                                      
REMARK 465     VAL C   750                                                      
REMARK 465     LYS C   751                                                      
REMARK 465     GLU C   752                                                      
REMARK 465     GLN C   753                                                      
REMARK 465     ALA C   754                                                      
REMARK 465     ILE C   755                                                      
REMARK 465     TRP C   756                                                      
REMARK 465     LYS C   757                                                      
REMARK 465     HIS C   758                                                      
REMARK 465     PRO C   759                                                      
REMARK 465     GLN C   760                                                      
REMARK 465     PRO C   761                                                      
REMARK 465     ALA C   762                                                      
REMARK 465     PRO C   763                                                      
REMARK 465     ALA C   764                                                      
REMARK 465     VAL C   765                                                      
REMARK 465     THR C   766                                                      
REMARK 465     PRO C   767                                                      
REMARK 465     ASP C   768                                                      
REMARK 465     PRO C   769                                                      
REMARK 465     TRP C   770                                                      
REMARK 465     GLY C   771                                                      
REMARK 465     VAL C   772                                                      
REMARK 465     GLN C   773                                                      
REMARK 465     GLY C   774                                                      
REMARK 465     GLY C   775                                                      
REMARK 465     GLN C   776                                                      
REMARK 465     GLU C   777                                                      
REMARK 465     SER C   778                                                      
REMARK 465     GLU C   779                                                      
REMARK 465     VAL C   780                                                      
REMARK 465     PRO C   781                                                      
REMARK 465     TYR C   782                                                      
REMARK 465     LYS C   783                                                      
REMARK 465     ARG C   784                                                      
REMARK 465     GLU C   785                                                      
REMARK 465     GLU C   786                                                      
REMARK 465     GLU C   787                                                      
REMARK 465     ALA C   788                                                      
REMARK 465     LEU C   789                                                      
REMARK 465     GLU C   790                                                      
REMARK 465     GLU C   791                                                      
REMARK 465     ARG C   792                                                      
REMARK 465     ARG C   793                                                      
REMARK 465     LEU C   794                                                      
REMARK 465     SER C   795                                                      
REMARK 465     ARG C   796                                                      
REMARK 465     GLY C   797                                                      
REMARK 465     GLU C   798                                                      
REMARK 465     ILE C   799                                                      
REMARK 465     PRO C   800                                                      
REMARK 465     THR C   801                                                      
REMARK 465     LEU C   802                                                      
REMARK 465     GLN C   803                                                      
REMARK 465     ARG C   804                                                      
REMARK 465     SER C   805                                                      
REMARK 465     MET D     1                                                      
REMARK 465     ASN D     2                                                      
REMARK 465     ALA D     3                                                      
REMARK 465     VAL D     4                                                      
REMARK 465     GLY D     5                                                      
REMARK 465     SER D     6                                                      
REMARK 465     PRO D     7                                                      
REMARK 465     GLU D     8                                                      
REMARK 465     GLY D     9                                                      
REMARK 465     GLN D    10                                                      
REMARK 465     GLU D    11                                                      
REMARK 465     LEU D    12                                                      
REMARK 465     GLN D    13                                                      
REMARK 465     LYS D    14                                                      
REMARK 465     LEU D    15                                                      
REMARK 465     GLY D    16                                                      
REMARK 465     SER D    17                                                      
REMARK 465     GLY D    18                                                      
REMARK 465     ALA D    19                                                      
REMARK 465     TRP D    20                                                      
REMARK 465     ASP D    21                                                      
REMARK 465     ASN D    22                                                      
REMARK 465     PRO D    23                                                      
REMARK 465     ALA D    24                                                      
REMARK 465     TYR D    25                                                      
REMARK 465     SER D    26                                                      
REMARK 465     GLY D    27                                                      
REMARK 465     PRO D    28                                                      
REMARK 465     PRO D    29                                                      
REMARK 465     SER D    30                                                      
REMARK 465     PRO D    31                                                      
REMARK 465     HIS D    32                                                      
REMARK 465     GLY D    33                                                      
REMARK 465     THR D    34                                                      
REMARK 465     LEU D    35                                                      
REMARK 465     ARG D    36                                                      
REMARK 465     VAL D    37                                                      
REMARK 465     CYS D    38                                                      
REMARK 465     THR D    39                                                      
REMARK 465     ILE D    40                                                      
REMARK 465     SER D    41                                                      
REMARK 465     SER D    42                                                      
REMARK 465     THR D    43                                                      
REMARK 465     GLY D    44                                                      
REMARK 465     PRO D    45                                                      
REMARK 465     LEU D    46                                                      
REMARK 465     GLN D    47                                                      
REMARK 465     PRO D    48                                                      
REMARK 465     GLN D    49                                                      
REMARK 465     PRO D    50                                                      
REMARK 465     LYS D    51                                                      
REMARK 465     LYS D    52                                                      
REMARK 465     PRO D    53                                                      
REMARK 465     GLU D    54                                                      
REMARK 465     ASP D    55                                                      
REMARK 465     GLU D    56                                                      
REMARK 465     PRO D    57                                                      
REMARK 465     GLN D    58                                                      
REMARK 465     GLU D    59                                                      
REMARK 465     THR D    60                                                      
REMARK 465     ALA D    61                                                      
REMARK 465     TYR D    62                                                      
REMARK 465     ARG D    63                                                      
REMARK 465     THR D    64                                                      
REMARK 465     GLN D    65                                                      
REMARK 465     VAL D    66                                                      
REMARK 465     SER D    67                                                      
REMARK 465     SER D    68                                                      
REMARK 465     CYS D    69                                                      
REMARK 465     CYS D    70                                                      
REMARK 465     LEU D    71                                                      
REMARK 465     HIS D    72                                                      
REMARK 465     ILE D    73                                                      
REMARK 465     CYS D    74                                                      
REMARK 465     GLN D    75                                                      
REMARK 465     GLY D    76                                                      
REMARK 465     ILE D    77                                                      
REMARK 465     ARG D    78                                                      
REMARK 465     GLY D    79                                                      
REMARK 465     LEU D    80                                                      
REMARK 465     TRP D    81                                                      
REMARK 465     GLY D    82                                                      
REMARK 465     THR D    83                                                      
REMARK 465     THR D    84                                                      
REMARK 465     LEU D    85                                                      
REMARK 465     THR D    86                                                      
REMARK 465     GLU D    87                                                      
REMARK 465     ASN D    88                                                      
REMARK 465     THR D    89                                                      
REMARK 465     ALA D    90                                                      
REMARK 465     GLU D    91                                                      
REMARK 465     ASN D    92                                                      
REMARK 465     ARG D    93                                                      
REMARK 465     GLU D    94                                                      
REMARK 465     LEU D    95                                                      
REMARK 465     TYR D    96                                                      
REMARK 465     ILE D    97                                                      
REMARK 465     LYS D    98                                                      
REMARK 465     THR D    99                                                      
REMARK 465     THR D   100                                                      
REMARK 465     LYS D   173                                                      
REMARK 465     TRP D   174                                                      
REMARK 465     TYR D   175                                                      
REMARK 465     ASN D   176                                                      
REMARK 465     ASN D   177                                                      
REMARK 465     GLN D   178                                                      
REMARK 465     SER D   179                                                      
REMARK 465     LEU D   180                                                      
REMARK 465     TYR D   344                                                      
REMARK 465     VAL D   345                                                      
REMARK 465     SER D   346                                                      
REMARK 465     ASN D   347                                                      
REMARK 465     TRP D   348                                                      
REMARK 465     ASP D   349                                                      
REMARK 465     PHE D   350                                                      
REMARK 465     LEU D   382                                                      
REMARK 465     SER D   383                                                      
REMARK 465     ILE D   457                                                      
REMARK 465     SER D   458                                                      
REMARK 465     PHE D   459                                                      
REMARK 465     ASN D   460                                                      
REMARK 465     LYS D   461                                                      
REMARK 465     THR D   462                                                      
REMARK 465     MET D   463                                                      
REMARK 465     THR D   464                                                      
REMARK 465     GLN D   465                                                      
REMARK 465     LEU D   466                                                      
REMARK 465     SER D   467                                                      
REMARK 465     SER D   468                                                      
REMARK 465     THR D   469                                                      
REMARK 465     LEU D   470                                                      
REMARK 465     ALA D   471                                                      
REMARK 465     ARG D   472                                                      
REMARK 465     CYS D   473                                                      
REMARK 465     ALA D   474                                                      
REMARK 465     LYS D   475                                                      
REMARK 465     ASP D   476                                                      
REMARK 465     ILE D   477                                                      
REMARK 465     LEU D   478                                                      
REMARK 465     GLY D   479                                                      
REMARK 465     ASP D   562                                                      
REMARK 465     THR D   563                                                      
REMARK 465     TYR D   564                                                      
REMARK 465     SER D   565                                                      
REMARK 465     GLU D   566                                                      
REMARK 465     VAL D   567                                                      
REMARK 465     LYS D   568                                                      
REMARK 465     GLU D   569                                                      
REMARK 465     GLU D   570                                                      
REMARK 465     LEU D   571                                                      
REMARK 465     ALA D   572                                                      
REMARK 465     GLY D   573                                                      
REMARK 465     GLN D   574                                                      
REMARK 465     LYS D   575                                                      
REMARK 465     ASP D   576                                                      
REMARK 465     GLU D   577                                                      
REMARK 465     LEU D   578                                                      
REMARK 465     GLN D   579                                                      
REMARK 465     LEU D   580                                                      
REMARK 465     SER D   581                                                      
REMARK 465     ASP D   582                                                      
REMARK 465     LEU D   583                                                      
REMARK 465     LEU D   584                                                      
REMARK 465     LYS D   585                                                      
REMARK 465     GLN D   586                                                      
REMARK 465     GLY D   587                                                      
REMARK 465     TYR D   588                                                      
REMARK 465     ASN D   589                                                      
REMARK 465     LYS D   590                                                      
REMARK 465     THR D   591                                                      
REMARK 465     LEU D   592                                                      
REMARK 465     LEU D   593                                                      
REMARK 465     ARG D   594                                                      
REMARK 465     LEU D   595                                                      
REMARK 465     ARG D   596                                                      
REMARK 465     LEU D   597                                                      
REMARK 465     ARG D   598                                                      
REMARK 465     LYS D   599                                                      
REMARK 465     GLU D   600                                                      
REMARK 465     ARG D   601                                                      
REMARK 465     VAL D   602                                                      
REMARK 465     SER D   603                                                      
REMARK 465     ASP D   604                                                      
REMARK 465     VAL D   605                                                      
REMARK 465     GLN D   606                                                      
REMARK 465     LYS D   607                                                      
REMARK 465     VAL D   608                                                      
REMARK 465     LEU D   609                                                      
REMARK 465     GLN D   610                                                      
REMARK 465     GLY D   611                                                      
REMARK 465     GLY D   612                                                      
REMARK 465     GLU D   613                                                      
REMARK 465     GLN D   614                                                      
REMARK 465     GLU D   615                                                      
REMARK 465     ILE D   616                                                      
REMARK 465     GLN D   617                                                      
REMARK 465     PHE D   618                                                      
REMARK 465     GLU D   619                                                      
REMARK 465     ASP D   620                                                      
REMARK 465     PHE D   621                                                      
REMARK 465     THR D   622                                                      
REMARK 465     ASN D   623                                                      
REMARK 465     THR D   624                                                      
REMARK 465     LEU D   625                                                      
REMARK 465     ARG D   626                                                      
REMARK 465     GLU D   627                                                      
REMARK 465     LEU D   628                                                      
REMARK 465     GLY D   629                                                      
REMARK 465     HIS D   630                                                      
REMARK 465     ALA D   631                                                      
REMARK 465     GLU D   632                                                      
REMARK 465     HIS D   633                                                      
REMARK 465     GLU D   634                                                      
REMARK 465     ILE D   635                                                      
REMARK 465     THR D   636                                                      
REMARK 465     GLU D   637                                                      
REMARK 465     LEU D   638                                                      
REMARK 465     THR D   639                                                      
REMARK 465     ALA D   640                                                      
REMARK 465     THR D   641                                                      
REMARK 465     PHE D   642                                                      
REMARK 465     THR D   643                                                      
REMARK 465     LYS D   644                                                      
REMARK 465     PHE D   645                                                      
REMARK 465     ASP D   646                                                      
REMARK 465     ARG D   647                                                      
REMARK 465     ASP D   648                                                      
REMARK 465     GLY D   649                                                      
REMARK 465     ASN D   650                                                      
REMARK 465     ARG D   651                                                      
REMARK 465     ILE D   652                                                      
REMARK 465     LEU D   653                                                      
REMARK 465     ASP D   654                                                      
REMARK 465     GLU D   655                                                      
REMARK 465     LYS D   656                                                      
REMARK 465     GLU D   657                                                      
REMARK 465     GLN D   658                                                      
REMARK 465     GLU D   659                                                      
REMARK 465     LYS D   660                                                      
REMARK 465     MET D   661                                                      
REMARK 465     ARG D   662                                                      
REMARK 465     GLN D   663                                                      
REMARK 465     ASP D   664                                                      
REMARK 465     LEU D   665                                                      
REMARK 465     GLU D   666                                                      
REMARK 465     GLU D   667                                                      
REMARK 465     GLU D   668                                                      
REMARK 465     ARG D   669                                                      
REMARK 465     VAL D   670                                                      
REMARK 465     ALA D   671                                                      
REMARK 465     LEU D   672                                                      
REMARK 465     ASN D   673                                                      
REMARK 465     THR D   674                                                      
REMARK 465     GLU D   675                                                      
REMARK 465     ILE D   676                                                      
REMARK 465     GLU D   677                                                      
REMARK 465     LYS D   678                                                      
REMARK 465     LEU D   679                                                      
REMARK 465     GLY D   680                                                      
REMARK 465     ARG D   681                                                      
REMARK 465     SER D   682                                                      
REMARK 465     ILE D   683                                                      
REMARK 465     VAL D   684                                                      
REMARK 465     SER D   685                                                      
REMARK 465     SER D   686                                                      
REMARK 465     PRO D   687                                                      
REMARK 465     GLN D   688                                                      
REMARK 465     GLY D   689                                                      
REMARK 465     LYS D   690                                                      
REMARK 465     SER D   691                                                      
REMARK 465     GLY D   692                                                      
REMARK 465     PRO D   693                                                      
REMARK 465     GLU D   694                                                      
REMARK 465     ALA D   695                                                      
REMARK 465     ALA D   696                                                      
REMARK 465     ARG D   697                                                      
REMARK 465     ALA D   698                                                      
REMARK 465     GLY D   699                                                      
REMARK 465     GLY D   700                                                      
REMARK 465     TRP D   701                                                      
REMARK 465     VAL D   702                                                      
REMARK 465     SER D   703                                                      
REMARK 465     GLY D   704                                                      
REMARK 465     GLU D   705                                                      
REMARK 465     GLU D   706                                                      
REMARK 465     PHE D   707                                                      
REMARK 465     TYR D   708                                                      
REMARK 465     MET D   709                                                      
REMARK 465     LEU D   710                                                      
REMARK 465     THR D   711                                                      
REMARK 465     ARG D   712                                                      
REMARK 465     ARG D   713                                                      
REMARK 465     VAL D   714                                                      
REMARK 465     LEU D   715                                                      
REMARK 465     GLN D   716                                                      
REMARK 465     LEU D   717                                                      
REMARK 465     GLU D   718                                                      
REMARK 465     THR D   719                                                      
REMARK 465     VAL D   720                                                      
REMARK 465     LEU D   721                                                      
REMARK 465     GLU D   722                                                      
REMARK 465     GLY D   723                                                      
REMARK 465     VAL D   724                                                      
REMARK 465     VAL D   725                                                      
REMARK 465     SER D   726                                                      
REMARK 465     GLN D   727                                                      
REMARK 465     ILE D   728                                                      
REMARK 465     ASP D   729                                                      
REMARK 465     ALA D   730                                                      
REMARK 465     VAL D   731                                                      
REMARK 465     GLY D   732                                                      
REMARK 465     SER D   733                                                      
REMARK 465     LYS D   734                                                      
REMARK 465     LEU D   735                                                      
REMARK 465     LYS D   736                                                      
REMARK 465     MET D   737                                                      
REMARK 465     LEU D   738                                                      
REMARK 465     GLU D   739                                                      
REMARK 465     ARG D   740                                                      
REMARK 465     LYS D   741                                                      
REMARK 465     GLY D   742                                                      
REMARK 465     TRP D   743                                                      
REMARK 465     LEU D   744                                                      
REMARK 465     ALA D   745                                                      
REMARK 465     PRO D   746                                                      
REMARK 465     SER D   747                                                      
REMARK 465     PRO D   748                                                      
REMARK 465     GLY D   749                                                      
REMARK 465     VAL D   750                                                      
REMARK 465     LYS D   751                                                      
REMARK 465     GLU D   752                                                      
REMARK 465     GLN D   753                                                      
REMARK 465     ALA D   754                                                      
REMARK 465     ILE D   755                                                      
REMARK 465     TRP D   756                                                      
REMARK 465     LYS D   757                                                      
REMARK 465     HIS D   758                                                      
REMARK 465     PRO D   759                                                      
REMARK 465     GLN D   760                                                      
REMARK 465     PRO D   761                                                      
REMARK 465     ALA D   762                                                      
REMARK 465     PRO D   763                                                      
REMARK 465     ALA D   764                                                      
REMARK 465     VAL D   765                                                      
REMARK 465     THR D   766                                                      
REMARK 465     PRO D   767                                                      
REMARK 465     ASP D   768                                                      
REMARK 465     PRO D   769                                                      
REMARK 465     TRP D   770                                                      
REMARK 465     GLY D   771                                                      
REMARK 465     VAL D   772                                                      
REMARK 465     GLN D   773                                                      
REMARK 465     GLY D   774                                                      
REMARK 465     GLY D   775                                                      
REMARK 465     GLN D   776                                                      
REMARK 465     GLU D   777                                                      
REMARK 465     SER D   778                                                      
REMARK 465     GLU D   779                                                      
REMARK 465     VAL D   780                                                      
REMARK 465     PRO D   781                                                      
REMARK 465     TYR D   782                                                      
REMARK 465     LYS D   783                                                      
REMARK 465     ARG D   784                                                      
REMARK 465     GLU D   785                                                      
REMARK 465     GLU D   786                                                      
REMARK 465     GLU D   787                                                      
REMARK 465     ALA D   788                                                      
REMARK 465     LEU D   789                                                      
REMARK 465     GLU D   790                                                      
REMARK 465     GLU D   791                                                      
REMARK 465     ARG D   792                                                      
REMARK 465     ARG D   793                                                      
REMARK 465     LEU D   794                                                      
REMARK 465     SER D   795                                                      
REMARK 465     ARG D   796                                                      
REMARK 465     GLY D   797                                                      
REMARK 465     GLU D   798                                                      
REMARK 465     ILE D   799                                                      
REMARK 465     PRO D   800                                                      
REMARK 465     THR D   801                                                      
REMARK 465     LEU D   802                                                      
REMARK 465     GLN D   803                                                      
REMARK 465     ARG D   804                                                      
REMARK 465     SER D   805                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LEU A 101    CG   CD1  CD2                                       
REMARK 470     ARG A 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A 105    CG   CD1  CD2                                       
REMARK 470     TYR A 107    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP A 113    CG   OD1  OD2                                       
REMARK 470     LEU A 117    CG   CD1  CD2                                       
REMARK 470     MET A 121    CG   SD   CE                                        
REMARK 470     GLU A 135    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 156    CG   OD1  OD2                                       
REMARK 470     ASP A 167    CG   OD1  OD2                                       
REMARK 470     GLU A 191    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 214    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 278    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A 292    CG   CD1  CD2                                       
REMARK 470     PHE A 315    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG A 343    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 369    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 370    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 373    CG   CD   OE1  OE2                                  
REMARK 470     HIS A 375    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TYR A 381    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE A 385    CG1  CG2  CD1                                       
REMARK 470     ASN A 387    CG   OD1  ND2                                       
REMARK 470     LEU A 391    CG   CD1  CD2                                       
REMARK 470     GLU A 429    CG   CD   OE1  OE2                                  
REMARK 470     MET A 441    CG   SD   CE                                        
REMARK 470     ILE A 451    CG1  CG2  CD1                                       
REMARK 470     LYS A 452    CG   CD   CE   NZ                                   
REMARK 470     LYS A 455    CG   CD   CE   NZ                                   
REMARK 470     TYR A 456    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     MET A 483    CG   SD   CE                                        
REMARK 470     MET A 555    CG   SD   CE                                        
REMARK 470     ILE A 559    CG1  CG2  CD1                                       
REMARK 470     LEU B 101    CG   CD1  CD2                                       
REMARK 470     ARG B 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU B 105    CG   CD1  CD2                                       
REMARK 470     TYR B 107    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP B 113    CG   OD1  OD2                                       
REMARK 470     LEU B 117    CG   CD1  CD2                                       
REMARK 470     MET B 121    CG   SD   CE                                        
REMARK 470     GLU B 135    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 156    CG   OD1  OD2                                       
REMARK 470     ASP B 167    CG   OD1  OD2                                       
REMARK 470     GLU B 191    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 214    CG   CD   OE1  OE2                                  
REMARK 470     ARG B 278    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU B 292    CG   CD1  CD2                                       
REMARK 470     PHE B 315    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG B 343    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B 369    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 370    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 373    CG   CD   OE1  OE2                                  
REMARK 470     HIS B 375    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TYR B 381    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE B 385    CG1  CG2  CD1                                       
REMARK 470     ASN B 387    CG   OD1  ND2                                       
REMARK 470     LEU B 391    CG   CD1  CD2                                       
REMARK 470     GLU B 429    CG   CD   OE1  OE2                                  
REMARK 470     MET B 441    CG   SD   CE                                        
REMARK 470     ILE B 451    CG1  CG2  CD1                                       
REMARK 470     LYS B 452    CG   CD   CE   NZ                                   
REMARK 470     LYS B 455    CG   CD   CE   NZ                                   
REMARK 470     TYR B 456    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     MET B 483    CG   SD   CE                                        
REMARK 470     MET B 555    CG   SD   CE                                        
REMARK 470     ILE B 559    CG1  CG2  CD1                                       
REMARK 470     LEU C 101    CG   CD1  CD2                                       
REMARK 470     ARG C 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU C 105    CG   CD1  CD2                                       
REMARK 470     TYR C 107    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP C 113    CG   OD1  OD2                                       
REMARK 470     LEU C 117    CG   CD1  CD2                                       
REMARK 470     MET C 121    CG   SD   CE                                        
REMARK 470     GLU C 135    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 156    CG   OD1  OD2                                       
REMARK 470     ASP C 167    CG   OD1  OD2                                       
REMARK 470     GLU C 191    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 214    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 278    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU C 292    CG   CD1  CD2                                       
REMARK 470     PHE C 315    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG C 343    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 369    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 370    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 373    CG   CD   OE1  OE2                                  
REMARK 470     HIS C 375    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TYR C 381    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE C 385    CG1  CG2  CD1                                       
REMARK 470     ASN C 387    CG   OD1  ND2                                       
REMARK 470     LEU C 391    CG   CD1  CD2                                       
REMARK 470     GLU C 429    CG   CD   OE1  OE2                                  
REMARK 470     MET C 441    CG   SD   CE                                        
REMARK 470     ILE C 451    CG1  CG2  CD1                                       
REMARK 470     LYS C 452    CG   CD   CE   NZ                                   
REMARK 470     LYS C 455    CG   CD   CE   NZ                                   
REMARK 470     TYR C 456    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     MET C 483    CG   SD   CE                                        
REMARK 470     MET C 555    CG   SD   CE                                        
REMARK 470     ILE C 559    CG1  CG2  CD1                                       
REMARK 470     LEU D 101    CG   CD1  CD2                                       
REMARK 470     ARG D 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU D 105    CG   CD1  CD2                                       
REMARK 470     TYR D 107    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP D 113    CG   OD1  OD2                                       
REMARK 470     LEU D 117    CG   CD1  CD2                                       
REMARK 470     MET D 121    CG   SD   CE                                        
REMARK 470     GLU D 135    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 156    CG   OD1  OD2                                       
REMARK 470     ASP D 167    CG   OD1  OD2                                       
REMARK 470     GLU D 191    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 214    CG   CD   OE1  OE2                                  
REMARK 470     ARG D 278    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU D 292    CG   CD1  CD2                                       
REMARK 470     PHE D 315    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG D 343    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D 369    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 370    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 373    CG   CD   OE1  OE2                                  
REMARK 470     HIS D 375    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TYR D 381    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE D 385    CG1  CG2  CD1                                       
REMARK 470     ASN D 387    CG   OD1  ND2                                       
REMARK 470     LEU D 391    CG   CD1  CD2                                       
REMARK 470     GLU D 429    CG   CD   OE1  OE2                                  
REMARK 470     MET D 441    CG   SD   CE                                        
REMARK 470     ILE D 451    CG1  CG2  CD1                                       
REMARK 470     LYS D 452    CG   CD   CE   NZ                                   
REMARK 470     LYS D 455    CG   CD   CE   NZ                                   
REMARK 470     TYR D 456    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     MET D 483    CG   SD   CE                                        
REMARK 470     MET D 555    CG   SD   CE                                        
REMARK 470     ILE D 559    CG1  CG2  CD1                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   CB   PHE A   315     CD2  LEU A   341              2.05            
REMARK 500   CB   PHE C   315     CD2  LEU C   341              2.05            
REMARK 500   CB   PHE B   315     CD2  LEU B   341              2.05            
REMARK 500   CB   PHE D   315     CD2  LEU D   341              2.05            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A 318   CA  -  CB  -  CG  ANGL. DEV. =  14.7 DEGREES          
REMARK 500    LEU B 318   CA  -  CB  -  CG  ANGL. DEV. =  14.7 DEGREES          
REMARK 500    LEU C 318   CA  -  CB  -  CG  ANGL. DEV. =  14.7 DEGREES          
REMARK 500    LEU D 318   CA  -  CB  -  CG  ANGL. DEV. =  14.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER A 184       24.30   -140.11                                   
REMARK 500    SER A 186       66.05     60.10                                   
REMARK 500    TYR A 190        8.24     84.60                                   
REMARK 500    GLU A 218      -12.42     68.86                                   
REMARK 500    THR A 243      -26.66     76.86                                   
REMARK 500    LEU A 341      -44.85     76.35                                   
REMARK 500    GLN A 421       71.49     51.50                                   
REMARK 500    THR A 501     -169.32    -74.66                                   
REMARK 500    GLN A 502       -7.44     71.91                                   
REMARK 500    ARG A 534       -4.82     74.07                                   
REMARK 500    SER B 184       24.30   -140.11                                   
REMARK 500    SER B 186       66.05     60.10                                   
REMARK 500    TYR B 190        8.24     84.60                                   
REMARK 500    GLU B 218      -12.42     68.86                                   
REMARK 500    THR B 243      -26.66     76.86                                   
REMARK 500    LEU B 341      -44.85     76.35                                   
REMARK 500    GLN B 421       71.49     51.50                                   
REMARK 500    THR B 501     -169.32    -74.66                                   
REMARK 500    GLN B 502       -7.44     71.91                                   
REMARK 500    ARG B 534       -4.82     74.07                                   
REMARK 500    SER C 184       24.30   -140.11                                   
REMARK 500    SER C 186       66.05     60.10                                   
REMARK 500    TYR C 190        8.24     84.60                                   
REMARK 500    GLU C 218      -12.42     68.86                                   
REMARK 500    THR C 243      -26.66     76.86                                   
REMARK 500    LEU C 341      -44.85     76.35                                   
REMARK 500    GLN C 421       71.49     51.50                                   
REMARK 500    THR C 501     -169.32    -74.66                                   
REMARK 500    GLN C 502       -7.44     71.91                                   
REMARK 500    ARG C 534       -4.82     74.07                                   
REMARK 500    SER D 184       24.30   -140.11                                   
REMARK 500    SER D 186       66.05     60.10                                   
REMARK 500    TYR D 190        8.24     84.60                                   
REMARK 500    GLU D 218      -12.42     68.86                                   
REMARK 500    THR D 243      -26.66     76.86                                   
REMARK 500    LEU D 341      -44.85     76.35                                   
REMARK 500    GLN D 421       71.49     51.50                                   
REMARK 500    THR D 501     -169.32    -74.66                                   
REMARK 500    GLN D 502       -7.44     71.91                                   
REMARK 500    ARG D 534       -4.82     74.07                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8912   RELATED DB: EMDB                              
REMARK 900 HUMAN POLYCSYTIN 2-L1                                                
DBREF  6DU8 A    1   805  UNP    Q9P0L9   PK2L1_HUMAN      1    805             
DBREF  6DU8 B    1   805  UNP    Q9P0L9   PK2L1_HUMAN      1    805             
DBREF  6DU8 C    1   805  UNP    Q9P0L9   PK2L1_HUMAN      1    805             
DBREF  6DU8 D    1   805  UNP    Q9P0L9   PK2L1_HUMAN      1    805             
SEQRES   1 A  805  MET ASN ALA VAL GLY SER PRO GLU GLY GLN GLU LEU GLN          
SEQRES   2 A  805  LYS LEU GLY SER GLY ALA TRP ASP ASN PRO ALA TYR SER          
SEQRES   3 A  805  GLY PRO PRO SER PRO HIS GLY THR LEU ARG VAL CYS THR          
SEQRES   4 A  805  ILE SER SER THR GLY PRO LEU GLN PRO GLN PRO LYS LYS          
SEQRES   5 A  805  PRO GLU ASP GLU PRO GLN GLU THR ALA TYR ARG THR GLN          
SEQRES   6 A  805  VAL SER SER CYS CYS LEU HIS ILE CYS GLN GLY ILE ARG          
SEQRES   7 A  805  GLY LEU TRP GLY THR THR LEU THR GLU ASN THR ALA GLU          
SEQRES   8 A  805  ASN ARG GLU LEU TYR ILE LYS THR THR LEU ARG GLU LEU          
SEQRES   9 A  805  LEU VAL TYR ILE VAL PHE LEU VAL ASP ILE CYS LEU LEU          
SEQRES  10 A  805  THR TYR GLY MET THR SER SER SER ALA TYR TYR TYR THR          
SEQRES  11 A  805  LYS VAL MET SER GLU LEU PHE LEU HIS THR PRO SER ASP          
SEQRES  12 A  805  THR GLY VAL SER PHE GLN ALA ILE SER SER MET ALA ASP          
SEQRES  13 A  805  PHE TRP ASP PHE ALA GLN GLY PRO LEU LEU ASP SER LEU          
SEQRES  14 A  805  TYR TRP THR LYS TRP TYR ASN ASN GLN SER LEU GLY HIS          
SEQRES  15 A  805  GLY SER HIS SER PHE ILE TYR TYR GLU ASN MET LEU LEU          
SEQRES  16 A  805  GLY VAL PRO ARG LEU ARG GLN LEU LYS VAL ARG ASN ASP          
SEQRES  17 A  805  SER CYS VAL VAL HIS GLU ASP PHE ARG GLU ASP ILE LEU          
SEQRES  18 A  805  SER CYS TYR ASP VAL TYR SER PRO ASP LYS GLU GLU GLN          
SEQRES  19 A  805  LEU PRO PHE GLY PRO PHE ASN GLY THR ALA TRP THR TYR          
SEQRES  20 A  805  HIS SER GLN ASP GLU LEU GLY GLY PHE SER HIS TRP GLY          
SEQRES  21 A  805  ARG LEU THR SER TYR SER GLY GLY GLY TYR TYR LEU ASP          
SEQRES  22 A  805  LEU PRO GLY SER ARG GLN GLY SER ALA GLU ALA LEU ARG          
SEQRES  23 A  805  ALA LEU GLN GLU GLY LEU TRP LEU ASP ARG GLY THR ARG          
SEQRES  24 A  805  VAL VAL PHE ILE ASP PHE SER VAL TYR ASN ALA ASN ILE          
SEQRES  25 A  805  ASN LEU PHE CYS VAL LEU ARG LEU VAL VAL GLU PHE PRO          
SEQRES  26 A  805  ALA THR GLY GLY ALA ILE PRO SER TRP GLN ILE ARG THR          
SEQRES  27 A  805  VAL LYS LEU ILE ARG TYR VAL SER ASN TRP ASP PHE PHE          
SEQRES  28 A  805  ILE VAL GLY CYS GLU VAL ILE PHE CYS VAL PHE ILE PHE          
SEQRES  29 A  805  TYR TYR VAL VAL GLU GLU ILE LEU GLU LEU HIS ILE HIS          
SEQRES  30 A  805  ARG LEU ARG TYR LEU SER SER ILE TRP ASN ILE LEU ASP          
SEQRES  31 A  805  LEU VAL VAL ILE LEU LEU SER ILE VAL ALA VAL GLY PHE          
SEQRES  32 A  805  HIS ILE PHE ARG THR LEU GLU VAL ASN ARG LEU MET GLY          
SEQRES  33 A  805  LYS LEU LEU GLN GLN PRO ASN THR TYR ALA ASP PHE GLU          
SEQRES  34 A  805  PHE LEU ALA PHE TRP GLN THR GLN TYR ASN ASN MET ASN          
SEQRES  35 A  805  ALA VAL ASN LEU PHE PHE ALA TRP ILE LYS ILE PHE LYS          
SEQRES  36 A  805  TYR ILE SER PHE ASN LYS THR MET THR GLN LEU SER SER          
SEQRES  37 A  805  THR LEU ALA ARG CYS ALA LYS ASP ILE LEU GLY PHE ALA          
SEQRES  38 A  805  VAL MET PHE PHE ILE VAL PHE PHE ALA TYR ALA GLN LEU          
SEQRES  39 A  805  GLY TYR LEU LEU PHE GLY THR GLN VAL GLU ASN PHE SER          
SEQRES  40 A  805  THR PHE ILE LYS CYS ILE PHE THR GLN PHE ARG ILE ILE          
SEQRES  41 A  805  LEU GLY ASP PHE ASP TYR ASN ALA ILE ASP ASN ALA ASN          
SEQRES  42 A  805  ARG ILE LEU GLY PRO ALA TYR PHE VAL THR TYR VAL PHE          
SEQRES  43 A  805  PHE VAL PHE PHE VAL LEU LEU ASN MET PHE LEU ALA ILE          
SEQRES  44 A  805  ILE ASN ASP THR TYR SER GLU VAL LYS GLU GLU LEU ALA          
SEQRES  45 A  805  GLY GLN LYS ASP GLU LEU GLN LEU SER ASP LEU LEU LYS          
SEQRES  46 A  805  GLN GLY TYR ASN LYS THR LEU LEU ARG LEU ARG LEU ARG          
SEQRES  47 A  805  LYS GLU ARG VAL SER ASP VAL GLN LYS VAL LEU GLN GLY          
SEQRES  48 A  805  GLY GLU GLN GLU ILE GLN PHE GLU ASP PHE THR ASN THR          
SEQRES  49 A  805  LEU ARG GLU LEU GLY HIS ALA GLU HIS GLU ILE THR GLU          
SEQRES  50 A  805  LEU THR ALA THR PHE THR LYS PHE ASP ARG ASP GLY ASN          
SEQRES  51 A  805  ARG ILE LEU ASP GLU LYS GLU GLN GLU LYS MET ARG GLN          
SEQRES  52 A  805  ASP LEU GLU GLU GLU ARG VAL ALA LEU ASN THR GLU ILE          
SEQRES  53 A  805  GLU LYS LEU GLY ARG SER ILE VAL SER SER PRO GLN GLY          
SEQRES  54 A  805  LYS SER GLY PRO GLU ALA ALA ARG ALA GLY GLY TRP VAL          
SEQRES  55 A  805  SER GLY GLU GLU PHE TYR MET LEU THR ARG ARG VAL LEU          
SEQRES  56 A  805  GLN LEU GLU THR VAL LEU GLU GLY VAL VAL SER GLN ILE          
SEQRES  57 A  805  ASP ALA VAL GLY SER LYS LEU LYS MET LEU GLU ARG LYS          
SEQRES  58 A  805  GLY TRP LEU ALA PRO SER PRO GLY VAL LYS GLU GLN ALA          
SEQRES  59 A  805  ILE TRP LYS HIS PRO GLN PRO ALA PRO ALA VAL THR PRO          
SEQRES  60 A  805  ASP PRO TRP GLY VAL GLN GLY GLY GLN GLU SER GLU VAL          
SEQRES  61 A  805  PRO TYR LYS ARG GLU GLU GLU ALA LEU GLU GLU ARG ARG          
SEQRES  62 A  805  LEU SER ARG GLY GLU ILE PRO THR LEU GLN ARG SER              
SEQRES   1 B  805  MET ASN ALA VAL GLY SER PRO GLU GLY GLN GLU LEU GLN          
SEQRES   2 B  805  LYS LEU GLY SER GLY ALA TRP ASP ASN PRO ALA TYR SER          
SEQRES   3 B  805  GLY PRO PRO SER PRO HIS GLY THR LEU ARG VAL CYS THR          
SEQRES   4 B  805  ILE SER SER THR GLY PRO LEU GLN PRO GLN PRO LYS LYS          
SEQRES   5 B  805  PRO GLU ASP GLU PRO GLN GLU THR ALA TYR ARG THR GLN          
SEQRES   6 B  805  VAL SER SER CYS CYS LEU HIS ILE CYS GLN GLY ILE ARG          
SEQRES   7 B  805  GLY LEU TRP GLY THR THR LEU THR GLU ASN THR ALA GLU          
SEQRES   8 B  805  ASN ARG GLU LEU TYR ILE LYS THR THR LEU ARG GLU LEU          
SEQRES   9 B  805  LEU VAL TYR ILE VAL PHE LEU VAL ASP ILE CYS LEU LEU          
SEQRES  10 B  805  THR TYR GLY MET THR SER SER SER ALA TYR TYR TYR THR          
SEQRES  11 B  805  LYS VAL MET SER GLU LEU PHE LEU HIS THR PRO SER ASP          
SEQRES  12 B  805  THR GLY VAL SER PHE GLN ALA ILE SER SER MET ALA ASP          
SEQRES  13 B  805  PHE TRP ASP PHE ALA GLN GLY PRO LEU LEU ASP SER LEU          
SEQRES  14 B  805  TYR TRP THR LYS TRP TYR ASN ASN GLN SER LEU GLY HIS          
SEQRES  15 B  805  GLY SER HIS SER PHE ILE TYR TYR GLU ASN MET LEU LEU          
SEQRES  16 B  805  GLY VAL PRO ARG LEU ARG GLN LEU LYS VAL ARG ASN ASP          
SEQRES  17 B  805  SER CYS VAL VAL HIS GLU ASP PHE ARG GLU ASP ILE LEU          
SEQRES  18 B  805  SER CYS TYR ASP VAL TYR SER PRO ASP LYS GLU GLU GLN          
SEQRES  19 B  805  LEU PRO PHE GLY PRO PHE ASN GLY THR ALA TRP THR TYR          
SEQRES  20 B  805  HIS SER GLN ASP GLU LEU GLY GLY PHE SER HIS TRP GLY          
SEQRES  21 B  805  ARG LEU THR SER TYR SER GLY GLY GLY TYR TYR LEU ASP          
SEQRES  22 B  805  LEU PRO GLY SER ARG GLN GLY SER ALA GLU ALA LEU ARG          
SEQRES  23 B  805  ALA LEU GLN GLU GLY LEU TRP LEU ASP ARG GLY THR ARG          
SEQRES  24 B  805  VAL VAL PHE ILE ASP PHE SER VAL TYR ASN ALA ASN ILE          
SEQRES  25 B  805  ASN LEU PHE CYS VAL LEU ARG LEU VAL VAL GLU PHE PRO          
SEQRES  26 B  805  ALA THR GLY GLY ALA ILE PRO SER TRP GLN ILE ARG THR          
SEQRES  27 B  805  VAL LYS LEU ILE ARG TYR VAL SER ASN TRP ASP PHE PHE          
SEQRES  28 B  805  ILE VAL GLY CYS GLU VAL ILE PHE CYS VAL PHE ILE PHE          
SEQRES  29 B  805  TYR TYR VAL VAL GLU GLU ILE LEU GLU LEU HIS ILE HIS          
SEQRES  30 B  805  ARG LEU ARG TYR LEU SER SER ILE TRP ASN ILE LEU ASP          
SEQRES  31 B  805  LEU VAL VAL ILE LEU LEU SER ILE VAL ALA VAL GLY PHE          
SEQRES  32 B  805  HIS ILE PHE ARG THR LEU GLU VAL ASN ARG LEU MET GLY          
SEQRES  33 B  805  LYS LEU LEU GLN GLN PRO ASN THR TYR ALA ASP PHE GLU          
SEQRES  34 B  805  PHE LEU ALA PHE TRP GLN THR GLN TYR ASN ASN MET ASN          
SEQRES  35 B  805  ALA VAL ASN LEU PHE PHE ALA TRP ILE LYS ILE PHE LYS          
SEQRES  36 B  805  TYR ILE SER PHE ASN LYS THR MET THR GLN LEU SER SER          
SEQRES  37 B  805  THR LEU ALA ARG CYS ALA LYS ASP ILE LEU GLY PHE ALA          
SEQRES  38 B  805  VAL MET PHE PHE ILE VAL PHE PHE ALA TYR ALA GLN LEU          
SEQRES  39 B  805  GLY TYR LEU LEU PHE GLY THR GLN VAL GLU ASN PHE SER          
SEQRES  40 B  805  THR PHE ILE LYS CYS ILE PHE THR GLN PHE ARG ILE ILE          
SEQRES  41 B  805  LEU GLY ASP PHE ASP TYR ASN ALA ILE ASP ASN ALA ASN          
SEQRES  42 B  805  ARG ILE LEU GLY PRO ALA TYR PHE VAL THR TYR VAL PHE          
SEQRES  43 B  805  PHE VAL PHE PHE VAL LEU LEU ASN MET PHE LEU ALA ILE          
SEQRES  44 B  805  ILE ASN ASP THR TYR SER GLU VAL LYS GLU GLU LEU ALA          
SEQRES  45 B  805  GLY GLN LYS ASP GLU LEU GLN LEU SER ASP LEU LEU LYS          
SEQRES  46 B  805  GLN GLY TYR ASN LYS THR LEU LEU ARG LEU ARG LEU ARG          
SEQRES  47 B  805  LYS GLU ARG VAL SER ASP VAL GLN LYS VAL LEU GLN GLY          
SEQRES  48 B  805  GLY GLU GLN GLU ILE GLN PHE GLU ASP PHE THR ASN THR          
SEQRES  49 B  805  LEU ARG GLU LEU GLY HIS ALA GLU HIS GLU ILE THR GLU          
SEQRES  50 B  805  LEU THR ALA THR PHE THR LYS PHE ASP ARG ASP GLY ASN          
SEQRES  51 B  805  ARG ILE LEU ASP GLU LYS GLU GLN GLU LYS MET ARG GLN          
SEQRES  52 B  805  ASP LEU GLU GLU GLU ARG VAL ALA LEU ASN THR GLU ILE          
SEQRES  53 B  805  GLU LYS LEU GLY ARG SER ILE VAL SER SER PRO GLN GLY          
SEQRES  54 B  805  LYS SER GLY PRO GLU ALA ALA ARG ALA GLY GLY TRP VAL          
SEQRES  55 B  805  SER GLY GLU GLU PHE TYR MET LEU THR ARG ARG VAL LEU          
SEQRES  56 B  805  GLN LEU GLU THR VAL LEU GLU GLY VAL VAL SER GLN ILE          
SEQRES  57 B  805  ASP ALA VAL GLY SER LYS LEU LYS MET LEU GLU ARG LYS          
SEQRES  58 B  805  GLY TRP LEU ALA PRO SER PRO GLY VAL LYS GLU GLN ALA          
SEQRES  59 B  805  ILE TRP LYS HIS PRO GLN PRO ALA PRO ALA VAL THR PRO          
SEQRES  60 B  805  ASP PRO TRP GLY VAL GLN GLY GLY GLN GLU SER GLU VAL          
SEQRES  61 B  805  PRO TYR LYS ARG GLU GLU GLU ALA LEU GLU GLU ARG ARG          
SEQRES  62 B  805  LEU SER ARG GLY GLU ILE PRO THR LEU GLN ARG SER              
SEQRES   1 C  805  MET ASN ALA VAL GLY SER PRO GLU GLY GLN GLU LEU GLN          
SEQRES   2 C  805  LYS LEU GLY SER GLY ALA TRP ASP ASN PRO ALA TYR SER          
SEQRES   3 C  805  GLY PRO PRO SER PRO HIS GLY THR LEU ARG VAL CYS THR          
SEQRES   4 C  805  ILE SER SER THR GLY PRO LEU GLN PRO GLN PRO LYS LYS          
SEQRES   5 C  805  PRO GLU ASP GLU PRO GLN GLU THR ALA TYR ARG THR GLN          
SEQRES   6 C  805  VAL SER SER CYS CYS LEU HIS ILE CYS GLN GLY ILE ARG          
SEQRES   7 C  805  GLY LEU TRP GLY THR THR LEU THR GLU ASN THR ALA GLU          
SEQRES   8 C  805  ASN ARG GLU LEU TYR ILE LYS THR THR LEU ARG GLU LEU          
SEQRES   9 C  805  LEU VAL TYR ILE VAL PHE LEU VAL ASP ILE CYS LEU LEU          
SEQRES  10 C  805  THR TYR GLY MET THR SER SER SER ALA TYR TYR TYR THR          
SEQRES  11 C  805  LYS VAL MET SER GLU LEU PHE LEU HIS THR PRO SER ASP          
SEQRES  12 C  805  THR GLY VAL SER PHE GLN ALA ILE SER SER MET ALA ASP          
SEQRES  13 C  805  PHE TRP ASP PHE ALA GLN GLY PRO LEU LEU ASP SER LEU          
SEQRES  14 C  805  TYR TRP THR LYS TRP TYR ASN ASN GLN SER LEU GLY HIS          
SEQRES  15 C  805  GLY SER HIS SER PHE ILE TYR TYR GLU ASN MET LEU LEU          
SEQRES  16 C  805  GLY VAL PRO ARG LEU ARG GLN LEU LYS VAL ARG ASN ASP          
SEQRES  17 C  805  SER CYS VAL VAL HIS GLU ASP PHE ARG GLU ASP ILE LEU          
SEQRES  18 C  805  SER CYS TYR ASP VAL TYR SER PRO ASP LYS GLU GLU GLN          
SEQRES  19 C  805  LEU PRO PHE GLY PRO PHE ASN GLY THR ALA TRP THR TYR          
SEQRES  20 C  805  HIS SER GLN ASP GLU LEU GLY GLY PHE SER HIS TRP GLY          
SEQRES  21 C  805  ARG LEU THR SER TYR SER GLY GLY GLY TYR TYR LEU ASP          
SEQRES  22 C  805  LEU PRO GLY SER ARG GLN GLY SER ALA GLU ALA LEU ARG          
SEQRES  23 C  805  ALA LEU GLN GLU GLY LEU TRP LEU ASP ARG GLY THR ARG          
SEQRES  24 C  805  VAL VAL PHE ILE ASP PHE SER VAL TYR ASN ALA ASN ILE          
SEQRES  25 C  805  ASN LEU PHE CYS VAL LEU ARG LEU VAL VAL GLU PHE PRO          
SEQRES  26 C  805  ALA THR GLY GLY ALA ILE PRO SER TRP GLN ILE ARG THR          
SEQRES  27 C  805  VAL LYS LEU ILE ARG TYR VAL SER ASN TRP ASP PHE PHE          
SEQRES  28 C  805  ILE VAL GLY CYS GLU VAL ILE PHE CYS VAL PHE ILE PHE          
SEQRES  29 C  805  TYR TYR VAL VAL GLU GLU ILE LEU GLU LEU HIS ILE HIS          
SEQRES  30 C  805  ARG LEU ARG TYR LEU SER SER ILE TRP ASN ILE LEU ASP          
SEQRES  31 C  805  LEU VAL VAL ILE LEU LEU SER ILE VAL ALA VAL GLY PHE          
SEQRES  32 C  805  HIS ILE PHE ARG THR LEU GLU VAL ASN ARG LEU MET GLY          
SEQRES  33 C  805  LYS LEU LEU GLN GLN PRO ASN THR TYR ALA ASP PHE GLU          
SEQRES  34 C  805  PHE LEU ALA PHE TRP GLN THR GLN TYR ASN ASN MET ASN          
SEQRES  35 C  805  ALA VAL ASN LEU PHE PHE ALA TRP ILE LYS ILE PHE LYS          
SEQRES  36 C  805  TYR ILE SER PHE ASN LYS THR MET THR GLN LEU SER SER          
SEQRES  37 C  805  THR LEU ALA ARG CYS ALA LYS ASP ILE LEU GLY PHE ALA          
SEQRES  38 C  805  VAL MET PHE PHE ILE VAL PHE PHE ALA TYR ALA GLN LEU          
SEQRES  39 C  805  GLY TYR LEU LEU PHE GLY THR GLN VAL GLU ASN PHE SER          
SEQRES  40 C  805  THR PHE ILE LYS CYS ILE PHE THR GLN PHE ARG ILE ILE          
SEQRES  41 C  805  LEU GLY ASP PHE ASP TYR ASN ALA ILE ASP ASN ALA ASN          
SEQRES  42 C  805  ARG ILE LEU GLY PRO ALA TYR PHE VAL THR TYR VAL PHE          
SEQRES  43 C  805  PHE VAL PHE PHE VAL LEU LEU ASN MET PHE LEU ALA ILE          
SEQRES  44 C  805  ILE ASN ASP THR TYR SER GLU VAL LYS GLU GLU LEU ALA          
SEQRES  45 C  805  GLY GLN LYS ASP GLU LEU GLN LEU SER ASP LEU LEU LYS          
SEQRES  46 C  805  GLN GLY TYR ASN LYS THR LEU LEU ARG LEU ARG LEU ARG          
SEQRES  47 C  805  LYS GLU ARG VAL SER ASP VAL GLN LYS VAL LEU GLN GLY          
SEQRES  48 C  805  GLY GLU GLN GLU ILE GLN PHE GLU ASP PHE THR ASN THR          
SEQRES  49 C  805  LEU ARG GLU LEU GLY HIS ALA GLU HIS GLU ILE THR GLU          
SEQRES  50 C  805  LEU THR ALA THR PHE THR LYS PHE ASP ARG ASP GLY ASN          
SEQRES  51 C  805  ARG ILE LEU ASP GLU LYS GLU GLN GLU LYS MET ARG GLN          
SEQRES  52 C  805  ASP LEU GLU GLU GLU ARG VAL ALA LEU ASN THR GLU ILE          
SEQRES  53 C  805  GLU LYS LEU GLY ARG SER ILE VAL SER SER PRO GLN GLY          
SEQRES  54 C  805  LYS SER GLY PRO GLU ALA ALA ARG ALA GLY GLY TRP VAL          
SEQRES  55 C  805  SER GLY GLU GLU PHE TYR MET LEU THR ARG ARG VAL LEU          
SEQRES  56 C  805  GLN LEU GLU THR VAL LEU GLU GLY VAL VAL SER GLN ILE          
SEQRES  57 C  805  ASP ALA VAL GLY SER LYS LEU LYS MET LEU GLU ARG LYS          
SEQRES  58 C  805  GLY TRP LEU ALA PRO SER PRO GLY VAL LYS GLU GLN ALA          
SEQRES  59 C  805  ILE TRP LYS HIS PRO GLN PRO ALA PRO ALA VAL THR PRO          
SEQRES  60 C  805  ASP PRO TRP GLY VAL GLN GLY GLY GLN GLU SER GLU VAL          
SEQRES  61 C  805  PRO TYR LYS ARG GLU GLU GLU ALA LEU GLU GLU ARG ARG          
SEQRES  62 C  805  LEU SER ARG GLY GLU ILE PRO THR LEU GLN ARG SER              
SEQRES   1 D  805  MET ASN ALA VAL GLY SER PRO GLU GLY GLN GLU LEU GLN          
SEQRES   2 D  805  LYS LEU GLY SER GLY ALA TRP ASP ASN PRO ALA TYR SER          
SEQRES   3 D  805  GLY PRO PRO SER PRO HIS GLY THR LEU ARG VAL CYS THR          
SEQRES   4 D  805  ILE SER SER THR GLY PRO LEU GLN PRO GLN PRO LYS LYS          
SEQRES   5 D  805  PRO GLU ASP GLU PRO GLN GLU THR ALA TYR ARG THR GLN          
SEQRES   6 D  805  VAL SER SER CYS CYS LEU HIS ILE CYS GLN GLY ILE ARG          
SEQRES   7 D  805  GLY LEU TRP GLY THR THR LEU THR GLU ASN THR ALA GLU          
SEQRES   8 D  805  ASN ARG GLU LEU TYR ILE LYS THR THR LEU ARG GLU LEU          
SEQRES   9 D  805  LEU VAL TYR ILE VAL PHE LEU VAL ASP ILE CYS LEU LEU          
SEQRES  10 D  805  THR TYR GLY MET THR SER SER SER ALA TYR TYR TYR THR          
SEQRES  11 D  805  LYS VAL MET SER GLU LEU PHE LEU HIS THR PRO SER ASP          
SEQRES  12 D  805  THR GLY VAL SER PHE GLN ALA ILE SER SER MET ALA ASP          
SEQRES  13 D  805  PHE TRP ASP PHE ALA GLN GLY PRO LEU LEU ASP SER LEU          
SEQRES  14 D  805  TYR TRP THR LYS TRP TYR ASN ASN GLN SER LEU GLY HIS          
SEQRES  15 D  805  GLY SER HIS SER PHE ILE TYR TYR GLU ASN MET LEU LEU          
SEQRES  16 D  805  GLY VAL PRO ARG LEU ARG GLN LEU LYS VAL ARG ASN ASP          
SEQRES  17 D  805  SER CYS VAL VAL HIS GLU ASP PHE ARG GLU ASP ILE LEU          
SEQRES  18 D  805  SER CYS TYR ASP VAL TYR SER PRO ASP LYS GLU GLU GLN          
SEQRES  19 D  805  LEU PRO PHE GLY PRO PHE ASN GLY THR ALA TRP THR TYR          
SEQRES  20 D  805  HIS SER GLN ASP GLU LEU GLY GLY PHE SER HIS TRP GLY          
SEQRES  21 D  805  ARG LEU THR SER TYR SER GLY GLY GLY TYR TYR LEU ASP          
SEQRES  22 D  805  LEU PRO GLY SER ARG GLN GLY SER ALA GLU ALA LEU ARG          
SEQRES  23 D  805  ALA LEU GLN GLU GLY LEU TRP LEU ASP ARG GLY THR ARG          
SEQRES  24 D  805  VAL VAL PHE ILE ASP PHE SER VAL TYR ASN ALA ASN ILE          
SEQRES  25 D  805  ASN LEU PHE CYS VAL LEU ARG LEU VAL VAL GLU PHE PRO          
SEQRES  26 D  805  ALA THR GLY GLY ALA ILE PRO SER TRP GLN ILE ARG THR          
SEQRES  27 D  805  VAL LYS LEU ILE ARG TYR VAL SER ASN TRP ASP PHE PHE          
SEQRES  28 D  805  ILE VAL GLY CYS GLU VAL ILE PHE CYS VAL PHE ILE PHE          
SEQRES  29 D  805  TYR TYR VAL VAL GLU GLU ILE LEU GLU LEU HIS ILE HIS          
SEQRES  30 D  805  ARG LEU ARG TYR LEU SER SER ILE TRP ASN ILE LEU ASP          
SEQRES  31 D  805  LEU VAL VAL ILE LEU LEU SER ILE VAL ALA VAL GLY PHE          
SEQRES  32 D  805  HIS ILE PHE ARG THR LEU GLU VAL ASN ARG LEU MET GLY          
SEQRES  33 D  805  LYS LEU LEU GLN GLN PRO ASN THR TYR ALA ASP PHE GLU          
SEQRES  34 D  805  PHE LEU ALA PHE TRP GLN THR GLN TYR ASN ASN MET ASN          
SEQRES  35 D  805  ALA VAL ASN LEU PHE PHE ALA TRP ILE LYS ILE PHE LYS          
SEQRES  36 D  805  TYR ILE SER PHE ASN LYS THR MET THR GLN LEU SER SER          
SEQRES  37 D  805  THR LEU ALA ARG CYS ALA LYS ASP ILE LEU GLY PHE ALA          
SEQRES  38 D  805  VAL MET PHE PHE ILE VAL PHE PHE ALA TYR ALA GLN LEU          
SEQRES  39 D  805  GLY TYR LEU LEU PHE GLY THR GLN VAL GLU ASN PHE SER          
SEQRES  40 D  805  THR PHE ILE LYS CYS ILE PHE THR GLN PHE ARG ILE ILE          
SEQRES  41 D  805  LEU GLY ASP PHE ASP TYR ASN ALA ILE ASP ASN ALA ASN          
SEQRES  42 D  805  ARG ILE LEU GLY PRO ALA TYR PHE VAL THR TYR VAL PHE          
SEQRES  43 D  805  PHE VAL PHE PHE VAL LEU LEU ASN MET PHE LEU ALA ILE          
SEQRES  44 D  805  ILE ASN ASP THR TYR SER GLU VAL LYS GLU GLU LEU ALA          
SEQRES  45 D  805  GLY GLN LYS ASP GLU LEU GLN LEU SER ASP LEU LEU LYS          
SEQRES  46 D  805  GLN GLY TYR ASN LYS THR LEU LEU ARG LEU ARG LEU ARG          
SEQRES  47 D  805  LYS GLU ARG VAL SER ASP VAL GLN LYS VAL LEU GLN GLY          
SEQRES  48 D  805  GLY GLU GLN GLU ILE GLN PHE GLU ASP PHE THR ASN THR          
SEQRES  49 D  805  LEU ARG GLU LEU GLY HIS ALA GLU HIS GLU ILE THR GLU          
SEQRES  50 D  805  LEU THR ALA THR PHE THR LYS PHE ASP ARG ASP GLY ASN          
SEQRES  51 D  805  ARG ILE LEU ASP GLU LYS GLU GLN GLU LYS MET ARG GLN          
SEQRES  52 D  805  ASP LEU GLU GLU GLU ARG VAL ALA LEU ASN THR GLU ILE          
SEQRES  53 D  805  GLU LYS LEU GLY ARG SER ILE VAL SER SER PRO GLN GLY          
SEQRES  54 D  805  LYS SER GLY PRO GLU ALA ALA ARG ALA GLY GLY TRP VAL          
SEQRES  55 D  805  SER GLY GLU GLU PHE TYR MET LEU THR ARG ARG VAL LEU          
SEQRES  56 D  805  GLN LEU GLU THR VAL LEU GLU GLY VAL VAL SER GLN ILE          
SEQRES  57 D  805  ASP ALA VAL GLY SER LYS LEU LYS MET LEU GLU ARG LYS          
SEQRES  58 D  805  GLY TRP LEU ALA PRO SER PRO GLY VAL LYS GLU GLN ALA          
SEQRES  59 D  805  ILE TRP LYS HIS PRO GLN PRO ALA PRO ALA VAL THR PRO          
SEQRES  60 D  805  ASP PRO TRP GLY VAL GLN GLY GLY GLN GLU SER GLU VAL          
SEQRES  61 D  805  PRO TYR LYS ARG GLU GLU GLU ALA LEU GLU GLU ARG ARG          
SEQRES  62 D  805  LEU SER ARG GLY GLU ILE PRO THR LEU GLN ARG SER              
HET    NAG  A 901      14                                                       
HET    NAG  B 901      14                                                       
HET    NAG  C 901      14                                                       
HET    NAG  D 901      14                                                       
HETNAM     NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE                         
FORMUL   5  NAG    4(C8 H15 N O6)                                               
HELIX    1 AA1 LEU A  104  TYR A  119  1                                  16    
HELIX    2 AA2 ALA A  126  LEU A  138  1                                  13    
HELIX    3 AA3 SER A  147  ILE A  151  5                                   5    
HELIX    4 AA4 ASP A  156  ALA A  161  1                                   6    
HELIX    5 AA5 SER A  249  GLY A  254  1                                   6    
HELIX    6 AA6 SER A  277  GLY A  291  1                                  15    
HELIX    7 AA7 CYS A  355  ILE A  376  1                                  22    
HELIX    8 AA8 ILE A  385  GLN A  420  1                                  36    
HELIX    9 AA9 PHE A  428  LYS A  452  1                                  25    
HELIX   10 AB1 ILE A  453  LYS A  455  5                                   3    
HELIX   11 AB2 ALA A  481  PHE A  499  1                                  19    
HELIX   12 AB3 ILE A  510  GLY A  522  1                                  13    
HELIX   13 AB4 LEU A  536  ILE A  560  1                                  25    
HELIX   14 AB5 LEU B  104  TYR B  119  1                                  16    
HELIX   15 AB6 ALA B  126  LEU B  138  1                                  13    
HELIX   16 AB7 SER B  147  ILE B  151  5                                   5    
HELIX   17 AB8 ASP B  156  ALA B  161  1                                   6    
HELIX   18 AB9 SER B  249  GLY B  254  1                                   6    
HELIX   19 AC1 SER B  277  GLY B  291  1                                  15    
HELIX   20 AC2 CYS B  355  ILE B  376  1                                  22    
HELIX   21 AC3 ILE B  385  GLN B  420  1                                  36    
HELIX   22 AC4 PHE B  428  LYS B  452  1                                  25    
HELIX   23 AC5 ILE B  453  LYS B  455  5                                   3    
HELIX   24 AC6 ALA B  481  PHE B  499  1                                  19    
HELIX   25 AC7 ILE B  510  GLY B  522  1                                  13    
HELIX   26 AC8 LEU B  536  ILE B  560  1                                  25    
HELIX   27 AC9 LEU C  104  TYR C  119  1                                  16    
HELIX   28 AD1 ALA C  126  LEU C  138  1                                  13    
HELIX   29 AD2 SER C  147  ILE C  151  5                                   5    
HELIX   30 AD3 ASP C  156  ALA C  161  1                                   6    
HELIX   31 AD4 SER C  249  GLY C  254  1                                   6    
HELIX   32 AD5 SER C  277  GLY C  291  1                                  15    
HELIX   33 AD6 CYS C  355  ILE C  376  1                                  22    
HELIX   34 AD7 ILE C  385  GLN C  420  1                                  36    
HELIX   35 AD8 PHE C  428  LYS C  452  1                                  25    
HELIX   36 AD9 ILE C  453  LYS C  455  5                                   3    
HELIX   37 AE1 ALA C  481  PHE C  499  1                                  19    
HELIX   38 AE2 ILE C  510  GLY C  522  1                                  13    
HELIX   39 AE3 LEU C  536  ILE C  560  1                                  25    
HELIX   40 AE4 LEU D  104  TYR D  119  1                                  16    
HELIX   41 AE5 ALA D  126  LEU D  138  1                                  13    
HELIX   42 AE6 SER D  147  ILE D  151  5                                   5    
HELIX   43 AE7 ASP D  156  ALA D  161  1                                   6    
HELIX   44 AE8 SER D  249  GLY D  254  1                                   6    
HELIX   45 AE9 SER D  277  GLY D  291  1                                  15    
HELIX   46 AF1 CYS D  355  ILE D  376  1                                  22    
HELIX   47 AF2 ILE D  385  GLN D  420  1                                  36    
HELIX   48 AF3 PHE D  428  LYS D  452  1                                  25    
HELIX   49 AF4 ILE D  453  LYS D  455  5                                   3    
HELIX   50 AF5 ALA D  481  PHE D  499  1                                  19    
HELIX   51 AF6 ILE D  510  GLY D  522  1                                  13    
HELIX   52 AF7 LEU D  536  ILE D  560  1                                  25    
SHEET    1 AA1 3 MET A 193  LEU A 194  0                                        
SHEET    2 AA1 3 THR A 298  ASN A 309 -1  O  TYR A 308   N  MET A 193           
SHEET    3 AA1 3 GLN A 202  LYS A 204 -1  N  LEU A 203   O  VAL A 300           
SHEET    1 AA2 4 MET A 193  LEU A 194  0                                        
SHEET    2 AA2 4 THR A 298  ASN A 309 -1  O  TYR A 308   N  MET A 193           
SHEET    3 AA2 4 LEU A 314  GLU A 323 -1  O  LEU A 318   N  PHE A 305           
SHEET    4 AA2 4 SER A 333  VAL A 339 -1  O  ARG A 337   N  VAL A 317           
SHEET    1 AA3 3 MET B 193  LEU B 194  0                                        
SHEET    2 AA3 3 THR B 298  ASN B 309 -1  O  TYR B 308   N  MET B 193           
SHEET    3 AA3 3 GLN B 202  LYS B 204 -1  N  LEU B 203   O  VAL B 300           
SHEET    1 AA4 4 MET B 193  LEU B 194  0                                        
SHEET    2 AA4 4 THR B 298  ASN B 309 -1  O  TYR B 308   N  MET B 193           
SHEET    3 AA4 4 LEU B 314  GLU B 323 -1  O  LEU B 318   N  PHE B 305           
SHEET    4 AA4 4 SER B 333  VAL B 339 -1  O  ARG B 337   N  VAL B 317           
SHEET    1 AA5 3 MET C 193  LEU C 194  0                                        
SHEET    2 AA5 3 THR C 298  ASN C 309 -1  O  TYR C 308   N  MET C 193           
SHEET    3 AA5 3 GLN C 202  LYS C 204 -1  N  LEU C 203   O  VAL C 300           
SHEET    1 AA6 4 MET C 193  LEU C 194  0                                        
SHEET    2 AA6 4 THR C 298  ASN C 309 -1  O  TYR C 308   N  MET C 193           
SHEET    3 AA6 4 LEU C 314  GLU C 323 -1  O  LEU C 318   N  PHE C 305           
SHEET    4 AA6 4 SER C 333  VAL C 339 -1  O  ARG C 337   N  VAL C 317           
SHEET    1 AA7 3 MET D 193  LEU D 194  0                                        
SHEET    2 AA7 3 THR D 298  ASN D 309 -1  O  TYR D 308   N  MET D 193           
SHEET    3 AA7 3 GLN D 202  LYS D 204 -1  N  LEU D 203   O  VAL D 300           
SHEET    1 AA8 4 MET D 193  LEU D 194  0                                        
SHEET    2 AA8 4 THR D 298  ASN D 309 -1  O  TYR D 308   N  MET D 193           
SHEET    3 AA8 4 LEU D 314  GLU D 323 -1  O  LEU D 318   N  PHE D 305           
SHEET    4 AA8 4 SER D 333  VAL D 339 -1  O  ARG D 337   N  VAL D 317           
LINK         ND2 ASN A 207                 C1  NAG A 901     1555   1555  1.44  
LINK         ND2 ASN A 207                 O5  NAG A 901     1555   1555  1.49  
LINK         ND2 ASN B 207                 C1  NAG B 901     1555   1555  1.44  
LINK         ND2 ASN B 207                 O5  NAG B 901     1555   1555  1.49  
LINK         ND2 ASN C 207                 C1  NAG C 901     1555   1555  1.44  
LINK         ND2 ASN C 207                 O5  NAG C 901     1555   1555  1.49  
LINK         ND2 ASN D 207                 C1  NAG D 901     1555   1555  1.44  
LINK         ND2 ASN D 207                 O5  NAG D 901     1555   1555  1.49  
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system