GenomeNet

Database: PDB
Entry: 6DV5
LinkDB: 6DV5
Original site: 6DV5 
HEADER    CHAPERONE                               22-JUN-18   6DV5              
TITLE     OLIGOMERIC COMPLEX OF A HSP27 24-MER AT 3.6 A RESOLUTION              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: HEAT SHOCK PROTEIN BETA-1;                                 
COMPND   3 CHAIN: B, A, D, F, H, J, L, N, P, R, T, V, X, C, E, G, I, K, M, O, Q,
COMPND   4 S, U, W;                                                             
COMPND   5 SYNONYM: HSPB1,28 KDA HEAT SHOCK PROTEIN,ESTROGEN-REGULATED 24 KDA   
COMPND   6 PROTEIN,HEAT SHOCK 27 KDA PROTEIN,HSP 27,STRESS-RESPONSIVE PROTEIN   
COMPND   7 27,SRP27;                                                            
COMPND   8 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: HSPB1, HSP27, HSP28;                                           
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    MOLECULAR CHAPERONE, SMALL HEAT SHOCK PROTEIN, ALPHA CRYSTALLIN       
KEYWDS   2 DOMAIN, CHAPERONE                                                    
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    A.H.AGUDA,G.D.BRAYER                                                  
REVDAT   2   08-JAN-20 6DV5    1       REMARK                                   
REVDAT   1   26-JUN-19 6DV5    0                                                
JRNL        AUTH   L.NAPPI,A.H.AGUDA,N.AL NAKOUZI,B.LELJ GAROLLA,E.BERALDI,     
JRNL        AUTH 2 N.LALLOUS,M.THI,S.MOORE,D.BATTSOGT,S.STOFFELIENE,F.BAN,      
JRNL        AUTH 3 N.T.NGUYEN,N.SAXENA,E.DUEVA,T.YAMAZAKI,A.ZOUBEIDI,           
JRNL        AUTH 4 A.CHERKASOV,G.D.BRAYER,M.GLEAVE                              
JRNL        TITL   STRUCTURE-GUIDED DISCOVERY OF IVERMECTIN AS AN INHIBITOR OF  
JRNL        TITL 2 HEAT SHOCK PROTEIN-27 PHOSPHORYLATION AND DEPOLYMERIZATION.  
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.58 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.8.0107                                      
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,              
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN                             
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.58                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 93.73                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.8                           
REMARK   3   NUMBER OF REFLECTIONS             : 87279                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.238                           
REMARK   3   R VALUE            (WORKING SET) : 0.238                           
REMARK   3   FREE R VALUE                     : 0.242                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 4645                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 3.58                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 3.67                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 6267                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 97.44                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2610                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 368                          
REMARK   3   BIN FREE R VALUE                    : 0.2670                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 32356                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 0                                       
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 65.08                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 0.69000                                              
REMARK   3    B22 (A**2) : 0.69000                                              
REMARK   3    B33 (A**2) : -1.37000                                             
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): NULL          
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.118         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.408         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 26.825        
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.812                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.793                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 33231 ; 0.013 ; 0.019       
REMARK   3   BOND LENGTHS OTHERS               (A): 30534 ; 0.017 ; 0.020       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 45063 ; 1.596 ; 1.955       
REMARK   3   BOND ANGLES OTHERS          (DEGREES): 70428 ; 2.801 ; 3.000       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  3896 ; 6.789 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):  1577 ;35.422 ;22.384       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  5266 ;16.421 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   342 ;11.705 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  4727 ; 0.098 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 36746 ; 0.011 ; 0.021       
REMARK   3   GENERAL PLANES OTHERS             (A):  7836 ; 0.011 ; 0.020       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NCS TYPE: LOCAL                                                    
REMARK   3   NUMBER OF DIFFERENT NCS PAIRS  : 132                               
REMARK   3  GROUP  CHAIN1    RANGE     CHAIN2     RANGE    COUNT RMS  WEIGHT    
REMARK   3    1     B     6    189       D     6    189   12172  0.26  0.05     
REMARK   3    2     B     6    189       F     6    189   12416  0.25  0.05     
REMARK   3    3     B     6    189       H     5    189   12552  0.24  0.05     
REMARK   3    4     B     6    189       J     6    189   12520  0.24  0.05     
REMARK   3    5     B     6    189       L     6    189   12572  0.23  0.05     
REMARK   3    6     B     6    189       N     6    189   11692  0.25  0.05     
REMARK   3    7     B     6    189       P     6    189   12602  0.24  0.05     
REMARK   3    8     B     6    189       R     6    189   12926  0.24  0.05     
REMARK   3    9     B     6    189       T     6    189   12892  0.24  0.05     
REMARK   3   10     B     6    189       V     6    189   12446  0.24  0.05     
REMARK   3   11     B     6    189       X     6    189   12392  0.25  0.05     
REMARK   3   12     A     1    191       C     1    191   12872  0.30  0.05     
REMARK   3   13     A     6    205       E     6    205   13058  0.29  0.05     
REMARK   3   14     A     2    205       G     2    205   13660  0.30  0.05     
REMARK   3   15     A     6    197       I     6    204   12978  0.29  0.05     
REMARK   3   16     A     1    205       K     1    205   13094  0.29  0.05     
REMARK   3   17     A     4    205       M     4    205   13654  0.29  0.05     
REMARK   3   18     A     1    205       O     1    205   13278  0.30  0.05     
REMARK   3   19     A     1    188       Q     1    188   12654  0.29  0.05     
REMARK   3   20     A     1    205       S     1    205   13424  0.29  0.05     
REMARK   3   21     A     1    205       U     1    205   13188  0.30  0.05     
REMARK   3   22     A     1    194       W     1    194   13206  0.29  0.05     
REMARK   3   23     D     5    205       F     5    205   13594  0.26  0.05     
REMARK   3   24     D     5    191       H     4    191   13272  0.22  0.05     
REMARK   3   25     D     5    205       J     5    205   13886  0.24  0.05     
REMARK   3   26     D     5    205       L     5    205   13860  0.24  0.05     
REMARK   3   27     D     5    205       N     5    205   12712  0.26  0.05     
REMARK   3   28     D     5    205       P     5    205   13854  0.23  0.05     
REMARK   3   29     D     5    205       R     5    205   13974  0.23  0.05     
REMARK   3   30     D     5    205       T     5    205   13986  0.25  0.05     
REMARK   3   31     D     5    205       V     5    205   13546  0.24  0.05     
REMARK   3   32     D     5    204       X     5    204   13934  0.23  0.05     
REMARK   3   33     F     5    191       H     4    191   13724  0.23  0.05     
REMARK   3   34     F     5    205       J     5    205   14152  0.22  0.05     
REMARK   3   35     F     5    205       L     5    205   13922  0.23  0.05     
REMARK   3   36     F     5    205       N     5    205   13342  0.23  0.05     
REMARK   3   37     F     5    205       P     5    205   14056  0.24  0.05     
REMARK   3   38     F     5    204       R     5    204   14250  0.22  0.05     
REMARK   3   39     F     5    204       T     5    204   14306  0.22  0.05     
REMARK   3   40     F     5    205       V     5    205   14258  0.23  0.05     
REMARK   3   41     F     5    204       X     5    204   14240  0.23  0.05     
REMARK   3   42     H     2    192       J     2    192   13562  0.23  0.05     
REMARK   3   43     H     1    191       L     1    191   13884  0.20  0.05     
REMARK   3   44     H     1    192       N     1    192   12688  0.24  0.05     
REMARK   3   45     H     1    192       P     1    192   13846  0.21  0.05     
REMARK   3   46     H     1    191       R     1    191   13942  0.21  0.05     
REMARK   3   47     H     2    191       T     2    191   13754  0.22  0.05     
REMARK   3   48     H     1    192       V     1    192   13736  0.21  0.05     
REMARK   3   49     H     1    191       X     1    191   13696  0.22  0.05     
REMARK   3   50     J     2    205       L     2    205   14062  0.22  0.05     
REMARK   3   51     J     2    205       N     2    205   12990  0.24  0.05     
REMARK   3   52     J     2    205       P     2    205   14282  0.23  0.05     
REMARK   3   53     J     2    205       R     2    205   14392  0.22  0.05     
REMARK   3   54     J     2    205       T     2    205   14536  0.22  0.05     
REMARK   3   55     J     2    205       V     2    205   14248  0.21  0.05     
REMARK   3   56     J     2    205       X     2    205   14076  0.23  0.05     
REMARK   3   57     L     1    205       N     1    205   13394  0.24  0.05     
REMARK   3   58     L     1    205       P     1    205   14478  0.22  0.05     
REMARK   3   59     L     1    205       R     1    205   14820  0.20  0.05     
REMARK   3   60     L     2    205       T     2    205   14424  0.21  0.05     
REMARK   3   61     L     1    205       V     1    205   14352  0.21  0.05     
REMARK   3   62     L     1    205       X     1    205   14278  0.23  0.05     
REMARK   3   63     N     1    205       P     1    205   13536  0.24  0.05     
REMARK   3   64     N     1    205       R     1    205   13840  0.22  0.05     
REMARK   3   65     N     2    205       T     2    205   13836  0.23  0.05     
REMARK   3   66     N     1    205       V     1    205   13626  0.23  0.05     
REMARK   3   67     N     1    205       X     1    205   13434  0.24  0.05     
REMARK   3   68     P     1    205       R     1    205   14678  0.22  0.05     
REMARK   3   69     P     2    205       T     2    205   14676  0.22  0.05     
REMARK   3   70     P     1    205       V     1    205   14158  0.22  0.05     
REMARK   3   71     P     1    205       X     1    205   14460  0.23  0.05     
REMARK   3   72     R     2    204       T     2    204   14816  0.21  0.05     
REMARK   3   73     R     1    205       V     1    205   14930  0.20  0.05     
REMARK   3   74     R     1    205       X     1    205   14774  0.22  0.05     
REMARK   3   75     T     2    205       V     2    205   14532  0.22  0.05     
REMARK   3   76     T     2    205       X     2    205   14474  0.23  0.05     
REMARK   3   77     V     1    205       X     1    205   14364  0.23  0.05     
REMARK   3   78     C     6    191       E     6    191   13236  0.25  0.05     
REMARK   3   79     C     2    191       G     2    191   13858  0.26  0.05     
REMARK   3   80     C     6    191       I     6    191   13550  0.26  0.05     
REMARK   3   81     C     1    191       K     1    191   13674  0.26  0.05     
REMARK   3   82     C     4    191       M     4    191   13542  0.27  0.05     
REMARK   3   83     C     1    191       O     1    191   13184  0.25  0.05     
REMARK   3   84     C     1    188       Q     1    188   13242  0.26  0.05     
REMARK   3   85     C     1    191       S     1    191   13052  0.28  0.05     
REMARK   3   86     C     1    191       U     1    191   13382  0.28  0.05     
REMARK   3   87     C     1    191       W     1    191   13804  0.26  0.05     
REMARK   3   88     E     6    204       G     6    204   14312  0.25  0.05     
REMARK   3   89     E     6    197       I     6    204   13928  0.25  0.05     
REMARK   3   90     E     6    205       K     6    205   13748  0.25  0.05     
REMARK   3   91     E     6    205       M     6    205   14634  0.26  0.05     
REMARK   3   92     E     6    205       O     6    205   13786  0.26  0.05     
REMARK   3   93     E     6    188       Q     6    188   12922  0.25  0.05     
REMARK   3   94     E     6    204       S     6    204   13592  0.27  0.05     
REMARK   3   95     E     6    205       U     6    205   13592  0.26  0.05     
REMARK   3   96     E     6    194       W     6    194   13802  0.24  0.05     
REMARK   3   97     G     6    197       I     6    204   14104  0.26  0.05     
REMARK   3   98     G     2    205       K     2    205   14098  0.26  0.05     
REMARK   3   99     G     4    204       M     4    204   14864  0.26  0.05     
REMARK   3  100     G     2    205       O     2    205   14192  0.26  0.05     
REMARK   3  101     G     2    188       Q     2    188   13382  0.26  0.05     
REMARK   3  102     G     2    204       S     2    204   14266  0.27  0.05     
REMARK   3  103     G     2    205       U     2    205   14204  0.27  0.05     
REMARK   3  104     G     2    194       W     2    194   14154  0.26  0.05     
REMARK   3  105     I     6    205       K     6    205   13856  0.25  0.05     
REMARK   3  106     I     6    204       M     6    197   14350  0.26  0.05     
REMARK   3  107     I     6    204       O     6    197   13344  0.26  0.05     
REMARK   3  108     I     6    188       Q     6    188   13074  0.26  0.05     
REMARK   3  109     I     6    204       S     6    197   13770  0.26  0.05     
REMARK   3  110     I     6    204       U     6    204   13666  0.28  0.05     
REMARK   3  111     I     6    194       W     6    194   14230  0.25  0.05     
REMARK   3  112     K     4    205       M     4    205   14078  0.26  0.05     
REMARK   3  113     K     1    205       O     1    205   13740  0.25  0.05     
REMARK   3  114     K     1    188       Q     1    188   13486  0.25  0.05     
REMARK   3  115     K     1    205       S     1    205   13768  0.27  0.05     
REMARK   3  116     K     1    205       U     1    205   13842  0.27  0.05     
REMARK   3  117     K     1    197       W     1    194   14040  0.23  0.05     
REMARK   3  118     M     4    205       O     4    205   14230  0.26  0.05     
REMARK   3  119     M     4    188       Q     4    188   13336  0.26  0.05     
REMARK   3  120     M     4    204       S     4    204   14240  0.27  0.05     
REMARK   3  121     M     4    205       U     4    205   14164  0.26  0.05     
REMARK   3  122     M     4    194       W     4    194   14226  0.25  0.05     
REMARK   3  123     O     1    188       Q     1    188   13010  0.25  0.05     
REMARK   3  124     O     1    205       S     1    205   13856  0.27  0.05     
REMARK   3  125     O     1    205       U     1    205   13534  0.27  0.05     
REMARK   3  126     O     1    194       W     1    194   13790  0.24  0.05     
REMARK   3  127     Q     1    188       S     1    188   13094  0.27  0.05     
REMARK   3  128     Q     1    188       U     1    188   13298  0.26  0.05     
REMARK   3  129     Q     1    188       W     1    188   13578  0.25  0.05     
REMARK   3  130     S     1    205       U     1    205   13544  0.28  0.05     
REMARK   3  131     S     1    194       W     1    194   13602  0.27  0.05     
REMARK   3  132     U     1    194       W     1    194   14162  0.26  0.05     
REMARK   3                                                                      
REMARK   3  TWIN DETAILS                                                        
REMARK   3   NUMBER OF TWIN DOMAINS  : 8                                        
REMARK   3      TWIN DOMAIN   : 1                                               
REMARK   3      TWIN OPERATOR : H, K, L                                         
REMARK   3      TWIN FRACTION : 0.580                                           
REMARK   3      TWIN DOMAIN   : 2                                               
REMARK   3      TWIN OPERATOR : K, H, -L                                        
REMARK   3      TWIN FRACTION : 0.057                                           
REMARK   3      TWIN DOMAIN   : 3                                               
REMARK   3      TWIN OPERATOR : -K, -1/3H+1/3K+4/3L, -2/3H-1/3K-1/3L            
REMARK   3      TWIN FRACTION : 0.062                                           
REMARK   3      TWIN DOMAIN   : 4                                               
REMARK   3      TWIN OPERATOR : -1/3H+1/3K+4/3L, -K, 2/3H+1/3K+1/3L             
REMARK   3      TWIN FRACTION : 0.061                                           
REMARK   3      TWIN DOMAIN   : 5                                               
REMARK   3      TWIN OPERATOR : 1/3H-1/3K-4/3L, -H, 1/3H+2/3K-1/3L              
REMARK   3      TWIN FRACTION : 0.062                                           
REMARK   3      TWIN DOMAIN   : 6                                               
REMARK   3      TWIN OPERATOR : -H, 1/3H-1/3K-4/3L, -1/3H-2/3K+1/3L             
REMARK   3      TWIN FRACTION : 0.061                                           
REMARK   3      TWIN DOMAIN   : 7                                               
REMARK   3      TWIN OPERATOR : -1/3H-2/3K+4/3L, H+K, -1/3H+1/3K+1/3L           
REMARK   3      TWIN FRACTION : 0.059                                           
REMARK   3      TWIN DOMAIN   : 8                                               
REMARK   3      TWIN OPERATOR : -2/3H-1/3K-4/3L, H+K, 1/3H-1/3K-1/3L            
REMARK   3      TWIN FRACTION : 0.059                                           
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : NULL                                                 
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING   
REMARK   3  POSITIONS                                                           
REMARK   4                                                                      
REMARK   4 6DV5 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 25-JUN-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000234398.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 21-APR-12                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : SSRL                               
REMARK 200  BEAMLINE                       : BL7-1                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0971                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315                   
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM                             
REMARK 200  DATA SCALING SOFTWARE          : SCALA                              
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 87279                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.579                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 93.730                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8                               
REMARK 200  DATA REDUNDANCY                : 2.500                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 2.7000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.58                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.67                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 2YGD                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 66.61                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.68                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.5 M AMMONIUM PHOSPHATE MONOBASIC AND   
REMARK 280  40 % TERT-BUTANOL., VAPOR DIFFUSION, SITTING DROP, TEMPERATURE      
REMARK 280  294.15K                                                             
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: H 3                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z                                                
REMARK 290       3555   -X+Y,-X,Z                                               
REMARK 290       4555   X+2/3,Y+1/3,Z+1/3                                       
REMARK 290       5555   -Y+2/3,X-Y+1/3,Z+1/3                                    
REMARK 290       6555   -X+Y+2/3,-X+1/3,Z+1/3                                   
REMARK 290       7555   X+1/3,Y+2/3,Z+2/3                                       
REMARK 290       8555   -Y+1/3,X-Y+2/3,Z+2/3                                    
REMARK 290       9555   -X+Y+1/3,-X+2/3,Z+2/3                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000      162.35000            
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       93.73282            
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       66.25367            
REMARK 290   SMTRY1   5 -0.500000 -0.866025  0.000000      162.35000            
REMARK 290   SMTRY2   5  0.866025 -0.500000  0.000000       93.73282            
REMARK 290   SMTRY3   5  0.000000  0.000000  1.000000       66.25367            
REMARK 290   SMTRY1   6 -0.500000  0.866025  0.000000      162.35000            
REMARK 290   SMTRY2   6 -0.866025 -0.500000  0.000000       93.73282            
REMARK 290   SMTRY3   6  0.000000  0.000000  1.000000       66.25367            
REMARK 290   SMTRY1   7  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   7  0.000000  1.000000  0.000000      187.46563            
REMARK 290   SMTRY3   7  0.000000  0.000000  1.000000      132.50733            
REMARK 290   SMTRY1   8 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   8  0.866025 -0.500000  0.000000      187.46563            
REMARK 290   SMTRY3   8  0.000000  0.000000  1.000000      132.50733            
REMARK 290   SMTRY1   9 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   9 -0.866025 -0.500000  0.000000      187.46563            
REMARK 290   SMTRY3   9  0.000000  0.000000  1.000000      132.50733            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 24-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, A, D, F, H, J, L, N, P, R,         
REMARK 350                    AND CHAINS: T, V, X, C, E, G, I, K, M,            
REMARK 350                    AND CHAINS: O, Q, S, U, W                         
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET B     1                                                      
REMARK 465     THR B     2                                                      
REMARK 465     GLU B     3                                                      
REMARK 465     ARG B     4                                                      
REMARK 465     ARG B     5                                                      
REMARK 465     ARG B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     PRO B    14                                                      
REMARK 465     PRO B    57                                                      
REMARK 465     LEU B    58                                                      
REMARK 465     PRO B    59                                                      
REMARK 465     PRO B    60                                                      
REMARK 465     ALA B    61                                                      
REMARK 465     ALA B    62                                                      
REMARK 465     ILE B    63                                                      
REMARK 465     GLU B    64                                                      
REMARK 465     SER B    65                                                      
REMARK 465     PRO B    66                                                      
REMARK 465     ALA B    67                                                      
REMARK 465     VAL B    68                                                      
REMARK 465     ALA B    69                                                      
REMARK 465     VAL B    85                                                      
REMARK 465     SER B    86                                                      
REMARK 465     GLU B    87                                                      
REMARK 465     ILE B    88                                                      
REMARK 465     ARG B    89                                                      
REMARK 465     HIS B    90                                                      
REMARK 465     THR B    91                                                      
REMARK 465     ALA B    92                                                      
REMARK 465     ASP B    93                                                      
REMARK 465     LYS B   171                                                      
REMARK 465     LEU B   172                                                      
REMARK 465     ALA B   173                                                      
REMARK 465     THR B   174                                                      
REMARK 465     LEU B   191                                                      
REMARK 465     GLY B   192                                                      
REMARK 465     GLY B   193                                                      
REMARK 465     PRO B   194                                                      
REMARK 465     GLU B   195                                                      
REMARK 465     ALA B   196                                                      
REMARK 465     ALA B   197                                                      
REMARK 465     LYS B   198                                                      
REMARK 465     SER B   199                                                      
REMARK 465     ASP B   200                                                      
REMARK 465     GLU B   201                                                      
REMARK 465     THR B   202                                                      
REMARK 465     ALA B   203                                                      
REMARK 465     ALA B   204                                                      
REMARK 465     LYS B   205                                                      
REMARK 465     PRO A    57                                                      
REMARK 465     LEU A    58                                                      
REMARK 465     PRO A    59                                                      
REMARK 465     PRO A    60                                                      
REMARK 465     ALA A    61                                                      
REMARK 465     ALA A    62                                                      
REMARK 465     ILE A    63                                                      
REMARK 465     GLU A    64                                                      
REMARK 465     SER A    65                                                      
REMARK 465     PRO A    66                                                      
REMARK 465     ALA A    67                                                      
REMARK 465     VAL A    68                                                      
REMARK 465     ALA A    69                                                      
REMARK 465     ALA A    70                                                      
REMARK 465     PRO A    71                                                      
REMARK 465     VAL A    85                                                      
REMARK 465     SER A    86                                                      
REMARK 465     GLU A    87                                                      
REMARK 465     ILE A    88                                                      
REMARK 465     ARG A    89                                                      
REMARK 465     HIS A    90                                                      
REMARK 465     THR A    91                                                      
REMARK 465     ALA A    92                                                      
REMARK 465     ASP A    93                                                      
REMARK 465     MET D     1                                                      
REMARK 465     THR D     2                                                      
REMARK 465     GLU D     3                                                      
REMARK 465     ARG D     4                                                      
REMARK 465     GLY D    13                                                      
REMARK 465     PRO D    14                                                      
REMARK 465     SER D    15                                                      
REMARK 465     TRP D    16                                                      
REMARK 465     ALA D    32                                                      
REMARK 465     PRO D    57                                                      
REMARK 465     LEU D    58                                                      
REMARK 465     PRO D    59                                                      
REMARK 465     PRO D    60                                                      
REMARK 465     ALA D    61                                                      
REMARK 465     ALA D    62                                                      
REMARK 465     ILE D    63                                                      
REMARK 465     GLU D    64                                                      
REMARK 465     SER D    65                                                      
REMARK 465     PRO D    66                                                      
REMARK 465     ALA D    67                                                      
REMARK 465     VAL D    68                                                      
REMARK 465     ALA D    69                                                      
REMARK 465     SER D    82                                                      
REMARK 465     SER D    83                                                      
REMARK 465     GLY D    84                                                      
REMARK 465     VAL D    85                                                      
REMARK 465     SER D    86                                                      
REMARK 465     GLU D    87                                                      
REMARK 465     ILE D    88                                                      
REMARK 465     LEU D   172                                                      
REMARK 465     ALA D   173                                                      
REMARK 465     THR D   174                                                      
REMARK 465     GLY D   193                                                      
REMARK 465     PRO D   194                                                      
REMARK 465     GLU D   195                                                      
REMARK 465     ALA D   196                                                      
REMARK 465     ALA D   197                                                      
REMARK 465     LYS D   198                                                      
REMARK 465     SER D   199                                                      
REMARK 465     ASP D   200                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     GLU F     3                                                      
REMARK 465     ARG F     4                                                      
REMARK 465     GLY F    13                                                      
REMARK 465     PRO F    14                                                      
REMARK 465     SER F    15                                                      
REMARK 465     TRP F    16                                                      
REMARK 465     LEU F    35                                                      
REMARK 465     PRO F    57                                                      
REMARK 465     LEU F    58                                                      
REMARK 465     PRO F    59                                                      
REMARK 465     PRO F    60                                                      
REMARK 465     ALA F    61                                                      
REMARK 465     ALA F    62                                                      
REMARK 465     ILE F    63                                                      
REMARK 465     GLU F    64                                                      
REMARK 465     SER F    65                                                      
REMARK 465     PRO F    66                                                      
REMARK 465     ALA F    67                                                      
REMARK 465     VAL F    68                                                      
REMARK 465     ALA F    69                                                      
REMARK 465     VAL F    85                                                      
REMARK 465     SER F    86                                                      
REMARK 465     GLU F    87                                                      
REMARK 465     ILE F    88                                                      
REMARK 465     ARG F    89                                                      
REMARK 465     HIS F    90                                                      
REMARK 465     THR F    91                                                      
REMARK 465     ALA F    92                                                      
REMARK 465     ASP F    93                                                      
REMARK 465     LEU F   172                                                      
REMARK 465     ALA F   173                                                      
REMARK 465     THR F   174                                                      
REMARK 465     GLY F   193                                                      
REMARK 465     PRO F   194                                                      
REMARK 465     GLU F   195                                                      
REMARK 465     ALA F   196                                                      
REMARK 465     ALA F   197                                                      
REMARK 465     LYS F   198                                                      
REMARK 465     SER F   199                                                      
REMARK 465     ASP F   200                                                      
REMARK 465     VAL H     6                                                      
REMARK 465     GLY H    13                                                      
REMARK 465     PRO H    14                                                      
REMARK 465     SER H    15                                                      
REMARK 465     TRP H    16                                                      
REMARK 465     LEU H    35                                                      
REMARK 465     PRO H    36                                                      
REMARK 465     PRO H    57                                                      
REMARK 465     LEU H    58                                                      
REMARK 465     PRO H    59                                                      
REMARK 465     PRO H    60                                                      
REMARK 465     ALA H    61                                                      
REMARK 465     ALA H    62                                                      
REMARK 465     ILE H    63                                                      
REMARK 465     GLU H    64                                                      
REMARK 465     SER H    65                                                      
REMARK 465     PRO H    66                                                      
REMARK 465     ALA H    67                                                      
REMARK 465     VAL H    68                                                      
REMARK 465     ALA H    69                                                      
REMARK 465     VAL H    85                                                      
REMARK 465     SER H    86                                                      
REMARK 465     GLU H    87                                                      
REMARK 465     ILE H    88                                                      
REMARK 465     ARG H    89                                                      
REMARK 465     HIS H    90                                                      
REMARK 465     THR H    91                                                      
REMARK 465     ALA H    92                                                      
REMARK 465     ASP H    93                                                      
REMARK 465     LEU H   172                                                      
REMARK 465     ALA H   173                                                      
REMARK 465     THR H   174                                                      
REMARK 465     GLY H   193                                                      
REMARK 465     PRO H   194                                                      
REMARK 465     GLU H   195                                                      
REMARK 465     ALA H   196                                                      
REMARK 465     ALA H   197                                                      
REMARK 465     LYS H   198                                                      
REMARK 465     SER H   199                                                      
REMARK 465     ASP H   200                                                      
REMARK 465     GLU H   201                                                      
REMARK 465     THR H   202                                                      
REMARK 465     ALA H   203                                                      
REMARK 465     ALA H   204                                                      
REMARK 465     LYS H   205                                                      
REMARK 465     MET J     1                                                      
REMARK 465     ARG J     4                                                      
REMARK 465     GLY J    13                                                      
REMARK 465     PRO J    14                                                      
REMARK 465     SER J    15                                                      
REMARK 465     TRP J    16                                                      
REMARK 465     PRO J    57                                                      
REMARK 465     LEU J    58                                                      
REMARK 465     PRO J    59                                                      
REMARK 465     PRO J    60                                                      
REMARK 465     ALA J    61                                                      
REMARK 465     ALA J    62                                                      
REMARK 465     ILE J    63                                                      
REMARK 465     GLU J    64                                                      
REMARK 465     SER J    65                                                      
REMARK 465     PRO J    66                                                      
REMARK 465     ALA J    67                                                      
REMARK 465     VAL J    68                                                      
REMARK 465     ALA J    69                                                      
REMARK 465     LEU J    81                                                      
REMARK 465     SER J    82                                                      
REMARK 465     SER J    83                                                      
REMARK 465     GLY J    84                                                      
REMARK 465     VAL J    85                                                      
REMARK 465     SER J    86                                                      
REMARK 465     GLU J    87                                                      
REMARK 465     ILE J    88                                                      
REMARK 465     ARG J    89                                                      
REMARK 465     HIS J    90                                                      
REMARK 465     THR J    91                                                      
REMARK 465     ALA J    92                                                      
REMARK 465     ASP J    93                                                      
REMARK 465     LEU J   172                                                      
REMARK 465     ALA J   173                                                      
REMARK 465     THR J   174                                                      
REMARK 465     GLY J   193                                                      
REMARK 465     PRO J   194                                                      
REMARK 465     GLU J   195                                                      
REMARK 465     ALA J   196                                                      
REMARK 465     ALA J   197                                                      
REMARK 465     LYS J   198                                                      
REMARK 465     SER J   199                                                      
REMARK 465     ASP J   200                                                      
REMARK 465     ARG L     4                                                      
REMARK 465     GLY L    13                                                      
REMARK 465     PRO L    14                                                      
REMARK 465     SER L    15                                                      
REMARK 465     TRP L    16                                                      
REMARK 465     VAL L    55                                                      
REMARK 465     ARG L    56                                                      
REMARK 465     PRO L    57                                                      
REMARK 465     LEU L    58                                                      
REMARK 465     PRO L    59                                                      
REMARK 465     PRO L    60                                                      
REMARK 465     ALA L    61                                                      
REMARK 465     ALA L    62                                                      
REMARK 465     ILE L    63                                                      
REMARK 465     GLU L    64                                                      
REMARK 465     SER L    65                                                      
REMARK 465     PRO L    66                                                      
REMARK 465     ALA L    67                                                      
REMARK 465     VAL L    68                                                      
REMARK 465     ALA L    69                                                      
REMARK 465     VAL L    85                                                      
REMARK 465     SER L    86                                                      
REMARK 465     GLU L    87                                                      
REMARK 465     ILE L    88                                                      
REMARK 465     ARG L    89                                                      
REMARK 465     HIS L    90                                                      
REMARK 465     THR L    91                                                      
REMARK 465     ALA L    92                                                      
REMARK 465     ASP L    93                                                      
REMARK 465     LEU L   172                                                      
REMARK 465     ALA L   173                                                      
REMARK 465     THR L   174                                                      
REMARK 465     GLY L   193                                                      
REMARK 465     PRO L   194                                                      
REMARK 465     GLU L   195                                                      
REMARK 465     ALA L   196                                                      
REMARK 465     ALA L   197                                                      
REMARK 465     LYS L   198                                                      
REMARK 465     SER L   199                                                      
REMARK 465     ASP L   200                                                      
REMARK 465     ARG N     4                                                      
REMARK 465     GLY N    13                                                      
REMARK 465     PRO N    14                                                      
REMARK 465     SER N    15                                                      
REMARK 465     TRP N    16                                                      
REMARK 465     PRO N    57                                                      
REMARK 465     LEU N    58                                                      
REMARK 465     PRO N    59                                                      
REMARK 465     PRO N    60                                                      
REMARK 465     ALA N    61                                                      
REMARK 465     ALA N    62                                                      
REMARK 465     ILE N    63                                                      
REMARK 465     GLU N    64                                                      
REMARK 465     SER N    65                                                      
REMARK 465     PRO N    66                                                      
REMARK 465     ALA N    67                                                      
REMARK 465     VAL N    68                                                      
REMARK 465     ALA N    69                                                      
REMARK 465     VAL N    85                                                      
REMARK 465     SER N    86                                                      
REMARK 465     GLU N    87                                                      
REMARK 465     ILE N    88                                                      
REMARK 465     ARG N    89                                                      
REMARK 465     HIS N    90                                                      
REMARK 465     THR N    91                                                      
REMARK 465     ALA N    92                                                      
REMARK 465     ASP N    93                                                      
REMARK 465     VAL N    97                                                      
REMARK 465     SER N    98                                                      
REMARK 465     LEU N    99                                                      
REMARK 465     PRO N   159                                                      
REMARK 465     GLU N   160                                                      
REMARK 465     LEU N   172                                                      
REMARK 465     ALA N   173                                                      
REMARK 465     THR N   174                                                      
REMARK 465     GLY N   193                                                      
REMARK 465     PRO N   194                                                      
REMARK 465     GLU N   195                                                      
REMARK 465     ALA N   196                                                      
REMARK 465     ALA N   197                                                      
REMARK 465     LYS N   198                                                      
REMARK 465     SER N   199                                                      
REMARK 465     ASP N   200                                                      
REMARK 465     ARG P     4                                                      
REMARK 465     GLY P    13                                                      
REMARK 465     PRO P    14                                                      
REMARK 465     SER P    15                                                      
REMARK 465     TRP P    16                                                      
REMARK 465     PRO P    57                                                      
REMARK 465     LEU P    58                                                      
REMARK 465     PRO P    59                                                      
REMARK 465     PRO P    60                                                      
REMARK 465     ALA P    61                                                      
REMARK 465     ALA P    62                                                      
REMARK 465     ILE P    63                                                      
REMARK 465     GLU P    64                                                      
REMARK 465     SER P    65                                                      
REMARK 465     PRO P    66                                                      
REMARK 465     ALA P    67                                                      
REMARK 465     VAL P    68                                                      
REMARK 465     ALA P    69                                                      
REMARK 465     GLN P    80                                                      
REMARK 465     LEU P    81                                                      
REMARK 465     SER P    82                                                      
REMARK 465     VAL P    85                                                      
REMARK 465     SER P    86                                                      
REMARK 465     GLU P    87                                                      
REMARK 465     ILE P    88                                                      
REMARK 465     ARG P    89                                                      
REMARK 465     HIS P    90                                                      
REMARK 465     THR P    91                                                      
REMARK 465     ALA P    92                                                      
REMARK 465     ASP P    93                                                      
REMARK 465     LEU P   172                                                      
REMARK 465     ALA P   173                                                      
REMARK 465     THR P   174                                                      
REMARK 465     GLY P   193                                                      
REMARK 465     PRO P   194                                                      
REMARK 465     GLU P   195                                                      
REMARK 465     ALA P   196                                                      
REMARK 465     ALA P   197                                                      
REMARK 465     LYS P   198                                                      
REMARK 465     SER P   199                                                      
REMARK 465     ASP P   200                                                      
REMARK 465     ARG R     4                                                      
REMARK 465     GLY R    13                                                      
REMARK 465     PRO R    14                                                      
REMARK 465     SER R    15                                                      
REMARK 465     TRP R    16                                                      
REMARK 465     PRO R    57                                                      
REMARK 465     LEU R    58                                                      
REMARK 465     PRO R    59                                                      
REMARK 465     PRO R    60                                                      
REMARK 465     ALA R    61                                                      
REMARK 465     ALA R    62                                                      
REMARK 465     ILE R    63                                                      
REMARK 465     GLU R    64                                                      
REMARK 465     SER R    65                                                      
REMARK 465     PRO R    66                                                      
REMARK 465     ALA R    67                                                      
REMARK 465     VAL R    68                                                      
REMARK 465     ALA R    69                                                      
REMARK 465     VAL R    85                                                      
REMARK 465     SER R    86                                                      
REMARK 465     GLU R    87                                                      
REMARK 465     ILE R    88                                                      
REMARK 465     ARG R    89                                                      
REMARK 465     HIS R    90                                                      
REMARK 465     THR R    91                                                      
REMARK 465     ALA R    92                                                      
REMARK 465     ASP R    93                                                      
REMARK 465     LEU R   172                                                      
REMARK 465     ALA R   173                                                      
REMARK 465     THR R   174                                                      
REMARK 465     GLY R   193                                                      
REMARK 465     PRO R   194                                                      
REMARK 465     GLU R   195                                                      
REMARK 465     ALA R   196                                                      
REMARK 465     ALA R   197                                                      
REMARK 465     LYS R   198                                                      
REMARK 465     SER R   199                                                      
REMARK 465     ASP R   200                                                      
REMARK 465     MET T     1                                                      
REMARK 465     ARG T     4                                                      
REMARK 465     GLY T    13                                                      
REMARK 465     PRO T    14                                                      
REMARK 465     SER T    15                                                      
REMARK 465     TRP T    16                                                      
REMARK 465     PRO T    57                                                      
REMARK 465     LEU T    58                                                      
REMARK 465     PRO T    59                                                      
REMARK 465     PRO T    60                                                      
REMARK 465     ALA T    61                                                      
REMARK 465     ALA T    62                                                      
REMARK 465     ILE T    63                                                      
REMARK 465     GLU T    64                                                      
REMARK 465     SER T    65                                                      
REMARK 465     PRO T    66                                                      
REMARK 465     ALA T    67                                                      
REMARK 465     VAL T    68                                                      
REMARK 465     ALA T    69                                                      
REMARK 465     VAL T    85                                                      
REMARK 465     SER T    86                                                      
REMARK 465     GLU T    87                                                      
REMARK 465     ILE T    88                                                      
REMARK 465     ARG T    89                                                      
REMARK 465     HIS T    90                                                      
REMARK 465     THR T    91                                                      
REMARK 465     ALA T    92                                                      
REMARK 465     ASP T    93                                                      
REMARK 465     LEU T   172                                                      
REMARK 465     ALA T   173                                                      
REMARK 465     THR T   174                                                      
REMARK 465     GLY T   193                                                      
REMARK 465     PRO T   194                                                      
REMARK 465     GLU T   195                                                      
REMARK 465     ALA T   196                                                      
REMARK 465     ALA T   197                                                      
REMARK 465     LYS T   198                                                      
REMARK 465     SER T   199                                                      
REMARK 465     ASP T   200                                                      
REMARK 465     ARG V     4                                                      
REMARK 465     GLY V    13                                                      
REMARK 465     PRO V    14                                                      
REMARK 465     SER V    15                                                      
REMARK 465     TRP V    16                                                      
REMARK 465     PRO V    57                                                      
REMARK 465     LEU V    58                                                      
REMARK 465     PRO V    59                                                      
REMARK 465     PRO V    60                                                      
REMARK 465     ALA V    61                                                      
REMARK 465     ALA V    62                                                      
REMARK 465     ILE V    63                                                      
REMARK 465     GLU V    64                                                      
REMARK 465     SER V    65                                                      
REMARK 465     PRO V    66                                                      
REMARK 465     ALA V    67                                                      
REMARK 465     VAL V    68                                                      
REMARK 465     ALA V    69                                                      
REMARK 465     ALA V    70                                                      
REMARK 465     PRO V    71                                                      
REMARK 465     ALA V    72                                                      
REMARK 465     VAL V    85                                                      
REMARK 465     SER V    86                                                      
REMARK 465     GLU V    87                                                      
REMARK 465     ILE V    88                                                      
REMARK 465     ARG V    89                                                      
REMARK 465     HIS V    90                                                      
REMARK 465     THR V    91                                                      
REMARK 465     ALA V    92                                                      
REMARK 465     ASP V    93                                                      
REMARK 465     ASP V   129                                                      
REMARK 465     GLU V   130                                                      
REMARK 465     HIS V   131                                                      
REMARK 465     LEU V   172                                                      
REMARK 465     ALA V   173                                                      
REMARK 465     THR V   174                                                      
REMARK 465     GLY V   193                                                      
REMARK 465     PRO V   194                                                      
REMARK 465     GLU V   195                                                      
REMARK 465     ALA V   196                                                      
REMARK 465     ALA V   197                                                      
REMARK 465     LYS V   198                                                      
REMARK 465     SER V   199                                                      
REMARK 465     ASP V   200                                                      
REMARK 465     ARG X     4                                                      
REMARK 465     GLY X    13                                                      
REMARK 465     PRO X    14                                                      
REMARK 465     SER X    15                                                      
REMARK 465     TRP X    16                                                      
REMARK 465     ALA X    32                                                      
REMARK 465     PRO X    57                                                      
REMARK 465     LEU X    58                                                      
REMARK 465     PRO X    59                                                      
REMARK 465     PRO X    60                                                      
REMARK 465     ALA X    61                                                      
REMARK 465     ALA X    62                                                      
REMARK 465     ILE X    63                                                      
REMARK 465     GLU X    64                                                      
REMARK 465     SER X    65                                                      
REMARK 465     PRO X    66                                                      
REMARK 465     ALA X    67                                                      
REMARK 465     VAL X    68                                                      
REMARK 465     ALA X    69                                                      
REMARK 465     VAL X    85                                                      
REMARK 465     SER X    86                                                      
REMARK 465     GLU X    87                                                      
REMARK 465     ILE X    88                                                      
REMARK 465     ARG X    89                                                      
REMARK 465     HIS X    90                                                      
REMARK 465     THR X    91                                                      
REMARK 465     ALA X    92                                                      
REMARK 465     ASP X    93                                                      
REMARK 465     LEU X   172                                                      
REMARK 465     ALA X   173                                                      
REMARK 465     THR X   174                                                      
REMARK 465     GLY X   193                                                      
REMARK 465     PRO X   194                                                      
REMARK 465     GLU X   195                                                      
REMARK 465     ALA X   196                                                      
REMARK 465     ALA X   197                                                      
REMARK 465     LYS X   198                                                      
REMARK 465     SER X   199                                                      
REMARK 465     ASP X   200                                                      
REMARK 465     PRO C    57                                                      
REMARK 465     LEU C    58                                                      
REMARK 465     PRO C    59                                                      
REMARK 465     PRO C    60                                                      
REMARK 465     ALA C    61                                                      
REMARK 465     ALA C    62                                                      
REMARK 465     ILE C    63                                                      
REMARK 465     GLU C    64                                                      
REMARK 465     SER C    65                                                      
REMARK 465     PRO C    66                                                      
REMARK 465     ALA C    67                                                      
REMARK 465     VAL C    68                                                      
REMARK 465     ALA C    69                                                      
REMARK 465     ALA C    70                                                      
REMARK 465     VAL C    85                                                      
REMARK 465     SER C    86                                                      
REMARK 465     GLU C    87                                                      
REMARK 465     ILE C    88                                                      
REMARK 465     ARG C    89                                                      
REMARK 465     HIS C    90                                                      
REMARK 465     THR C    91                                                      
REMARK 465     ALA C    92                                                      
REMARK 465     ARG C    94                                                      
REMARK 465     LEU C   172                                                      
REMARK 465     ALA C   173                                                      
REMARK 465     THR C   174                                                      
REMARK 465     GLY C   193                                                      
REMARK 465     PRO C   194                                                      
REMARK 465     GLU C   195                                                      
REMARK 465     ALA C   196                                                      
REMARK 465     ALA C   197                                                      
REMARK 465     LYS C   198                                                      
REMARK 465     SER C   199                                                      
REMARK 465     ASP C   200                                                      
REMARK 465     GLU C   201                                                      
REMARK 465     THR C   202                                                      
REMARK 465     ALA C   203                                                      
REMARK 465     ALA C   204                                                      
REMARK 465     LYS C   205                                                      
REMARK 465     MET E     1                                                      
REMARK 465     THR E     2                                                      
REMARK 465     GLU E     3                                                      
REMARK 465     ARG E     4                                                      
REMARK 465     ARG E     5                                                      
REMARK 465     SER E    43                                                      
REMARK 465     GLN E    44                                                      
REMARK 465     PRO E    57                                                      
REMARK 465     LEU E    58                                                      
REMARK 465     PRO E    59                                                      
REMARK 465     PRO E    60                                                      
REMARK 465     ALA E    61                                                      
REMARK 465     ALA E    62                                                      
REMARK 465     ILE E    63                                                      
REMARK 465     GLU E    64                                                      
REMARK 465     SER E    65                                                      
REMARK 465     PRO E    66                                                      
REMARK 465     ALA E    67                                                      
REMARK 465     VAL E    68                                                      
REMARK 465     ALA E    69                                                      
REMARK 465     ALA E    70                                                      
REMARK 465     GLY E    84                                                      
REMARK 465     VAL E    85                                                      
REMARK 465     SER E    86                                                      
REMARK 465     GLU E    87                                                      
REMARK 465     ILE E    88                                                      
REMARK 465     ARG E    89                                                      
REMARK 465     HIS E    90                                                      
REMARK 465     THR E    91                                                      
REMARK 465     ALA E    92                                                      
REMARK 465     ALA E   173                                                      
REMARK 465     THR E   174                                                      
REMARK 465     MET G     1                                                      
REMARK 465     PRO G    57                                                      
REMARK 465     LEU G    58                                                      
REMARK 465     PRO G    59                                                      
REMARK 465     PRO G    60                                                      
REMARK 465     ALA G    61                                                      
REMARK 465     ALA G    62                                                      
REMARK 465     ILE G    63                                                      
REMARK 465     GLU G    64                                                      
REMARK 465     SER G    65                                                      
REMARK 465     PRO G    66                                                      
REMARK 465     ALA G    67                                                      
REMARK 465     VAL G    68                                                      
REMARK 465     ALA G    69                                                      
REMARK 465     ALA G    70                                                      
REMARK 465     VAL G    85                                                      
REMARK 465     SER G    86                                                      
REMARK 465     GLU G    87                                                      
REMARK 465     ILE G    88                                                      
REMARK 465     ARG G    89                                                      
REMARK 465     HIS G    90                                                      
REMARK 465     THR G    91                                                      
REMARK 465     ALA G    92                                                      
REMARK 465     ASP G    93                                                      
REMARK 465     ALA G   173                                                      
REMARK 465     THR G   174                                                      
REMARK 465     MET I     1                                                      
REMARK 465     THR I     2                                                      
REMARK 465     GLU I     3                                                      
REMARK 465     ARG I     4                                                      
REMARK 465     ARG I     5                                                      
REMARK 465     PRO I    57                                                      
REMARK 465     LEU I    58                                                      
REMARK 465     PRO I    59                                                      
REMARK 465     PRO I    60                                                      
REMARK 465     ALA I    61                                                      
REMARK 465     ALA I    62                                                      
REMARK 465     ILE I    63                                                      
REMARK 465     GLU I    64                                                      
REMARK 465     SER I    65                                                      
REMARK 465     PRO I    66                                                      
REMARK 465     ALA I    67                                                      
REMARK 465     VAL I    68                                                      
REMARK 465     ALA I    69                                                      
REMARK 465     ALA I    70                                                      
REMARK 465     VAL I    85                                                      
REMARK 465     SER I    86                                                      
REMARK 465     GLU I    87                                                      
REMARK 465     ILE I    88                                                      
REMARK 465     ARG I    89                                                      
REMARK 465     HIS I    90                                                      
REMARK 465     THR I    91                                                      
REMARK 465     ALA I    92                                                      
REMARK 465     ASP I    93                                                      
REMARK 465     ALA I   173                                                      
REMARK 465     THR I   174                                                      
REMARK 465     ALA I   196                                                      
REMARK 465     ALA I   197                                                      
REMARK 465     LYS I   198                                                      
REMARK 465     SER I   199                                                      
REMARK 465     ASP I   200                                                      
REMARK 465     GLU I   201                                                      
REMARK 465     PRO K    57                                                      
REMARK 465     LEU K    58                                                      
REMARK 465     PRO K    59                                                      
REMARK 465     PRO K    60                                                      
REMARK 465     ALA K    61                                                      
REMARK 465     ALA K    62                                                      
REMARK 465     ILE K    63                                                      
REMARK 465     GLU K    64                                                      
REMARK 465     SER K    65                                                      
REMARK 465     PRO K    66                                                      
REMARK 465     ALA K    67                                                      
REMARK 465     VAL K    68                                                      
REMARK 465     ALA K    69                                                      
REMARK 465     ALA K    70                                                      
REMARK 465     VAL K    85                                                      
REMARK 465     SER K    86                                                      
REMARK 465     GLU K    87                                                      
REMARK 465     ILE K    88                                                      
REMARK 465     ARG K    89                                                      
REMARK 465     HIS K    90                                                      
REMARK 465     THR K    91                                                      
REMARK 465     ALA K    92                                                      
REMARK 465     ASP K    93                                                      
REMARK 465     LYS K   171                                                      
REMARK 465     LEU K   172                                                      
REMARK 465     ALA K   173                                                      
REMARK 465     THR K   174                                                      
REMARK 465     GLY K   192                                                      
REMARK 465     GLY K   193                                                      
REMARK 465     PRO K   194                                                      
REMARK 465     MET M     1                                                      
REMARK 465     THR M     2                                                      
REMARK 465     GLU M     3                                                      
REMARK 465     PRO M    57                                                      
REMARK 465     LEU M    58                                                      
REMARK 465     PRO M    59                                                      
REMARK 465     PRO M    60                                                      
REMARK 465     ALA M    61                                                      
REMARK 465     ALA M    62                                                      
REMARK 465     ILE M    63                                                      
REMARK 465     GLU M    64                                                      
REMARK 465     SER M    65                                                      
REMARK 465     PRO M    66                                                      
REMARK 465     ALA M    67                                                      
REMARK 465     VAL M    68                                                      
REMARK 465     ALA M    69                                                      
REMARK 465     ALA M    70                                                      
REMARK 465     VAL M    85                                                      
REMARK 465     SER M    86                                                      
REMARK 465     GLU M    87                                                      
REMARK 465     ILE M    88                                                      
REMARK 465     ARG M    89                                                      
REMARK 465     HIS M    90                                                      
REMARK 465     THR M    91                                                      
REMARK 465     ALA M    92                                                      
REMARK 465     ASP M    93                                                      
REMARK 465     ALA M   173                                                      
REMARK 465     THR M   174                                                      
REMARK 465     PRO O    57                                                      
REMARK 465     LEU O    58                                                      
REMARK 465     PRO O    59                                                      
REMARK 465     PRO O    60                                                      
REMARK 465     ALA O    61                                                      
REMARK 465     ALA O    62                                                      
REMARK 465     ILE O    63                                                      
REMARK 465     GLU O    64                                                      
REMARK 465     SER O    65                                                      
REMARK 465     PRO O    66                                                      
REMARK 465     ALA O    67                                                      
REMARK 465     VAL O    68                                                      
REMARK 465     ALA O    69                                                      
REMARK 465     ALA O    70                                                      
REMARK 465     VAL O    85                                                      
REMARK 465     SER O    86                                                      
REMARK 465     GLU O    87                                                      
REMARK 465     ILE O    88                                                      
REMARK 465     ARG O    89                                                      
REMARK 465     HIS O    90                                                      
REMARK 465     THR O    91                                                      
REMARK 465     ALA O    92                                                      
REMARK 465     ASP O    93                                                      
REMARK 465     ALA O   173                                                      
REMARK 465     THR O   174                                                      
REMARK 465     GLN O   175                                                      
REMARK 465     SER O   176                                                      
REMARK 465     ASN O   177                                                      
REMARK 465     GLU O   178                                                      
REMARK 465     ILE O   179                                                      
REMARK 465     THR O   180                                                      
REMARK 465     PRO Q    57                                                      
REMARK 465     LEU Q    58                                                      
REMARK 465     PRO Q    59                                                      
REMARK 465     PRO Q    60                                                      
REMARK 465     ALA Q    61                                                      
REMARK 465     ALA Q    62                                                      
REMARK 465     ILE Q    63                                                      
REMARK 465     GLU Q    64                                                      
REMARK 465     SER Q    65                                                      
REMARK 465     PRO Q    66                                                      
REMARK 465     ALA Q    67                                                      
REMARK 465     VAL Q    68                                                      
REMARK 465     ALA Q    69                                                      
REMARK 465     ALA Q    70                                                      
REMARK 465     VAL Q    85                                                      
REMARK 465     SER Q    86                                                      
REMARK 465     GLU Q    87                                                      
REMARK 465     ILE Q    88                                                      
REMARK 465     ARG Q    89                                                      
REMARK 465     HIS Q    90                                                      
REMARK 465     THR Q    91                                                      
REMARK 465     ALA Q    92                                                      
REMARK 465     ASP Q    93                                                      
REMARK 465     PRO Q   170                                                      
REMARK 465     LYS Q   171                                                      
REMARK 465     LEU Q   172                                                      
REMARK 465     ALA Q   173                                                      
REMARK 465     THR Q   174                                                      
REMARK 465     GLN Q   190                                                      
REMARK 465     LEU Q   191                                                      
REMARK 465     GLY Q   192                                                      
REMARK 465     GLY Q   193                                                      
REMARK 465     PRO Q   194                                                      
REMARK 465     GLU Q   195                                                      
REMARK 465     ALA Q   196                                                      
REMARK 465     ALA Q   197                                                      
REMARK 465     LYS Q   198                                                      
REMARK 465     SER Q   199                                                      
REMARK 465     ASP Q   200                                                      
REMARK 465     GLU Q   201                                                      
REMARK 465     THR Q   202                                                      
REMARK 465     ALA Q   203                                                      
REMARK 465     ALA Q   204                                                      
REMARK 465     LYS Q   205                                                      
REMARK 465     PRO S    57                                                      
REMARK 465     LEU S    58                                                      
REMARK 465     PRO S    59                                                      
REMARK 465     PRO S    60                                                      
REMARK 465     ALA S    61                                                      
REMARK 465     ALA S    62                                                      
REMARK 465     ILE S    63                                                      
REMARK 465     GLU S    64                                                      
REMARK 465     SER S    65                                                      
REMARK 465     PRO S    66                                                      
REMARK 465     ALA S    67                                                      
REMARK 465     VAL S    68                                                      
REMARK 465     ALA S    69                                                      
REMARK 465     ALA S    70                                                      
REMARK 465     VAL S    85                                                      
REMARK 465     SER S    86                                                      
REMARK 465     GLU S    87                                                      
REMARK 465     ILE S    88                                                      
REMARK 465     ARG S    89                                                      
REMARK 465     HIS S    90                                                      
REMARK 465     THR S    91                                                      
REMARK 465     ALA S    92                                                      
REMARK 465     ASP S    93                                                      
REMARK 465     ALA S   173                                                      
REMARK 465     THR S   174                                                      
REMARK 465     PRO U    57                                                      
REMARK 465     LEU U    58                                                      
REMARK 465     PRO U    59                                                      
REMARK 465     PRO U    60                                                      
REMARK 465     ALA U    61                                                      
REMARK 465     ALA U    62                                                      
REMARK 465     ILE U    63                                                      
REMARK 465     GLU U    64                                                      
REMARK 465     SER U    65                                                      
REMARK 465     PRO U    66                                                      
REMARK 465     ALA U    67                                                      
REMARK 465     VAL U    68                                                      
REMARK 465     ALA U    69                                                      
REMARK 465     ALA U    70                                                      
REMARK 465     VAL U    85                                                      
REMARK 465     SER U    86                                                      
REMARK 465     GLU U    87                                                      
REMARK 465     ILE U    88                                                      
REMARK 465     ARG U    89                                                      
REMARK 465     HIS U    90                                                      
REMARK 465     THR U    91                                                      
REMARK 465     ALA U    92                                                      
REMARK 465     ASP U    93                                                      
REMARK 465     LEU U   172                                                      
REMARK 465     ALA U   173                                                      
REMARK 465     THR U   174                                                      
REMARK 465     LYS U   198                                                      
REMARK 465     SER U   199                                                      
REMARK 465     ASP U   200                                                      
REMARK 465     GLU U   201                                                      
REMARK 465     PRO W    57                                                      
REMARK 465     LEU W    58                                                      
REMARK 465     PRO W    59                                                      
REMARK 465     PRO W    60                                                      
REMARK 465     ALA W    61                                                      
REMARK 465     ALA W    62                                                      
REMARK 465     ILE W    63                                                      
REMARK 465     GLU W    64                                                      
REMARK 465     SER W    65                                                      
REMARK 465     PRO W    66                                                      
REMARK 465     ALA W    67                                                      
REMARK 465     VAL W    68                                                      
REMARK 465     ALA W    69                                                      
REMARK 465     ALA W    70                                                      
REMARK 465     VAL W    85                                                      
REMARK 465     SER W    86                                                      
REMARK 465     GLU W    87                                                      
REMARK 465     ILE W    88                                                      
REMARK 465     ARG W    89                                                      
REMARK 465     HIS W    90                                                      
REMARK 465     THR W    91                                                      
REMARK 465     ALA W    92                                                      
REMARK 465     ASP W    93                                                      
REMARK 465     ALA W   173                                                      
REMARK 465     THR W   174                                                      
REMARK 465     THR W   180                                                      
REMARK 465     ALA W   196                                                      
REMARK 465     ALA W   197                                                      
REMARK 465     LYS W   198                                                      
REMARK 465     SER W   199                                                      
REMARK 465     ASP W   200                                                      
REMARK 465     GLU W   201                                                      
REMARK 465     THR W   202                                                      
REMARK 465     ALA W   203                                                      
REMARK 465     ALA W   204                                                      
REMARK 465     LYS W   205                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     PRO C  14    CG   CD                                             
REMARK 470     PRO E  14    CG   CD                                             
REMARK 470     PRO G  14    CG   CD                                             
REMARK 470     PRO I  14    CG   CD                                             
REMARK 470     PRO K  14    CG   CD                                             
REMARK 470     PRO M  14    CG   CD                                             
REMARK 470     PRO O  14    CG   CD                                             
REMARK 470     PRO Q  14    CG   CD                                             
REMARK 470     PRO S  14    CG   CD                                             
REMARK 470     PRO U  14    CG   CD                                             
REMARK 470     PRO W  14    CG   CD                                             
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO E  14   N   -  CA  -  CB  ANGL. DEV. =   8.2 DEGREES          
REMARK 500    PRO I  14   N   -  CA  -  CB  ANGL. DEV. =   7.4 DEGREES          
REMARK 500    PRO K  14   N   -  CA  -  CB  ANGL. DEV. =   8.0 DEGREES          
REMARK 500    PRO M  14   N   -  CA  -  CB  ANGL. DEV. =   7.8 DEGREES          
REMARK 500    PRO O  14   N   -  CA  -  CB  ANGL. DEV. =   8.0 DEGREES          
REMARK 500    PRO Q  14   N   -  CA  -  CB  ANGL. DEV. =   8.4 DEGREES          
REMARK 500    PRO S   7   C   -  N   -  CD  ANGL. DEV. = -13.1 DEGREES          
REMARK 500    PRO W  14   N   -  CA  -  CB  ANGL. DEV. =   8.3 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU B  10     -149.11    -90.10                                   
REMARK 500    TRP B  16     -143.44    -93.32                                   
REMARK 500    ASP B  17     -115.52     48.95                                   
REMARK 500    PHE B  19      -50.50   -160.11                                   
REMARK 500    TRP B  22     -169.38   -107.74                                   
REMARK 500    PRO B  36       32.08    -94.06                                   
REMARK 500    GLU B  41       81.39     58.45                                   
REMARK 500    TRP B  45      -55.70   -150.21                                   
REMARK 500    LEU B  46      -31.90     81.09                                   
REMARK 500    TRP B  51      165.68     64.91                                   
REMARK 500    TYR B  54      -70.59    -99.55                                   
REMARK 500    ARG B  79       37.34     71.80                                   
REMARK 500    GLN B  80        6.42     59.41                                   
REMARK 500    SER B  83     -115.86     62.19                                   
REMARK 500    ILE B 134       83.85    -46.42                                   
REMARK 500    PRO B 145       98.32    -68.69                                   
REMARK 500    SER B 176     -122.79    -91.56                                   
REMARK 500    ASN B 177      -69.29     35.73                                   
REMARK 500    VAL B 183       82.75   -156.94                                   
REMARK 500    GLU B 186        0.66    104.93                                   
REMARK 500    ALA B 189       77.90    -53.52                                   
REMARK 500    THR A   2     -153.16   -146.17                                   
REMARK 500    GLU A   3       71.29     52.23                                   
REMARK 500    ARG A   4       72.44     38.55                                   
REMARK 500    ARG A   5     -166.42     69.38                                   
REMARK 500    VAL A   6      100.52     88.16                                   
REMARK 500    PHE A   8       30.14    -90.80                                   
REMARK 500    ARG A  12     -172.95   -171.28                                   
REMARK 500    PRO A  14       83.96    -63.93                                   
REMARK 500    SER A  15      -78.95   -149.35                                   
REMARK 500    TRP A  16     -124.07   -157.09                                   
REMARK 500    ASP A  17      156.55    -37.70                                   
REMARK 500    PRO A  18       34.69    -62.59                                   
REMARK 500    PHE A  19      133.83   -179.22                                   
REMARK 500    ASP A  21      -74.81   -114.96                                   
REMARK 500    TYR A  23       82.28     43.13                                   
REMARK 500    PRO A  24      104.74    -56.52                                   
REMARK 500    GLU A  40        5.43    -58.63                                   
REMARK 500    GLU A  41     -171.61     78.55                                   
REMARK 500    TRP A  42      -98.06   -107.27                                   
REMARK 500    SER A  43      -61.96   -137.67                                   
REMARK 500    GLN A  44      -58.08    115.27                                   
REMARK 500    LEU A  46      -68.02   -120.48                                   
REMARK 500    TRP A  51      -67.39    117.36                                   
REMARK 500    ARG A  79      -88.25    -89.09                                   
REMARK 500    GLN A  80      -58.54     55.48                                   
REMARK 500    SER A  83      -14.17     59.13                                   
REMARK 500    HIS A 124     -110.46   -112.52                                   
REMARK 500    GLU A 125      117.36     70.81                                   
REMARK 500    GLU A 126     -111.80   -163.87                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     585 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  6DV5 B    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 A    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 D    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 F    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 H    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 J    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 L    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 N    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 P    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 R    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 T    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 V    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 X    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 C    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 E    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 G    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 I    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 K    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 M    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 O    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 Q    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 S    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 U    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
DBREF  6DV5 W    1   205  UNP    P04792   HSPB1_HUMAN      1    205             
SEQRES   1 B  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 B  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 B  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 B  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 B  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 B  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 B  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 B  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 B  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 B  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 B  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 B  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 B  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 B  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 B  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 B  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 A  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 A  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 A  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 A  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 A  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 A  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 A  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 A  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 A  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 A  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 A  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 A  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 A  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 A  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 A  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 A  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 D  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 D  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 D  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 D  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 D  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 D  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 D  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 D  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 D  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 D  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 D  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 D  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 D  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 D  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 D  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 D  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 F  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 F  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 F  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 F  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 F  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 F  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 F  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 F  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 F  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 F  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 F  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 F  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 F  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 F  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 F  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 F  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 H  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 H  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 H  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 H  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 H  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 H  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 H  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 H  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 H  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 H  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 H  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 H  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 H  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 H  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 H  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 H  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 J  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 J  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 J  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 J  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 J  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 J  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 J  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 J  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 J  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 J  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 J  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 J  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 J  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 J  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 J  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 J  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 L  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 L  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 L  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 L  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 L  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 L  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 L  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 L  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 L  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 L  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 L  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 L  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 L  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 L  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 L  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 L  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 N  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 N  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 N  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 N  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 N  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 N  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 N  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 N  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 N  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 N  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 N  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 N  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 N  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 N  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 N  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 N  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 P  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 P  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 P  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 P  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 P  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 P  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 P  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 P  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 P  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 P  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 P  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 P  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 P  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 P  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 P  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 P  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 R  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 R  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 R  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 R  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 R  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 R  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 R  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 R  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 R  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 R  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 R  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 R  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 R  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 R  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 R  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 R  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 T  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 T  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 T  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 T  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 T  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 T  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 T  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 T  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 T  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 T  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 T  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 T  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 T  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 T  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 T  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 T  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 V  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 V  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 V  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 V  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 V  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 V  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 V  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 V  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 V  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 V  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 V  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 V  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 V  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 V  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 V  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 V  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 X  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 X  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 X  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 X  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 X  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 X  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 X  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 X  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 X  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 X  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 X  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 X  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 X  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 X  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 X  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 X  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 C  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 C  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 C  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 C  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 C  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 C  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 C  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 C  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 C  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 C  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 C  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 C  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 C  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 C  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 C  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 C  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 E  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 E  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 E  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 E  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 E  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 E  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 E  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 E  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 E  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 E  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 E  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 E  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 E  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 E  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 E  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 E  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 G  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 G  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 G  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 G  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 G  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 G  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 G  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 G  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 G  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 G  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 G  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 G  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 G  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 G  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 G  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 G  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 I  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 I  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 I  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 I  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 I  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 I  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 I  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 I  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 I  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 I  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 I  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 I  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 I  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 I  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 I  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 I  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 K  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 K  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 K  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 K  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 K  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 K  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 K  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 K  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 K  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 K  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 K  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 K  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 K  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 K  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 K  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 K  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 M  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 M  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 M  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 M  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 M  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 M  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 M  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 M  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 M  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 M  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 M  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 M  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 M  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 M  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 M  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 M  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 O  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 O  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 O  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 O  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 O  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 O  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 O  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 O  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 O  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 O  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 O  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 O  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 O  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 O  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 O  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 O  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 Q  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 Q  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 Q  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 Q  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 Q  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 Q  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 Q  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 Q  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 Q  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 Q  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 Q  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 Q  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 Q  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 Q  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 Q  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 Q  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 S  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 S  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 S  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 S  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 S  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 S  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 S  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 S  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 S  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 S  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 S  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 S  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 S  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 S  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 S  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 S  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 U  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 U  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 U  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 U  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 U  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 U  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 U  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 U  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 U  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 U  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 U  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 U  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 U  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 U  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 U  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 U  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
SEQRES   1 W  205  MET THR GLU ARG ARG VAL PRO PHE SER LEU LEU ARG GLY          
SEQRES   2 W  205  PRO SER TRP ASP PRO PHE ARG ASP TRP TYR PRO HIS SER          
SEQRES   3 W  205  ARG LEU PHE ASP GLN ALA PHE GLY LEU PRO ARG LEU PRO          
SEQRES   4 W  205  GLU GLU TRP SER GLN TRP LEU GLY GLY SER SER TRP PRO          
SEQRES   5 W  205  GLY TYR VAL ARG PRO LEU PRO PRO ALA ALA ILE GLU SER          
SEQRES   6 W  205  PRO ALA VAL ALA ALA PRO ALA TYR SER ARG ALA LEU SER          
SEQRES   7 W  205  ARG GLN LEU SER SER GLY VAL SER GLU ILE ARG HIS THR          
SEQRES   8 W  205  ALA ASP ARG TRP ARG VAL SER LEU ASP VAL ASN HIS PHE          
SEQRES   9 W  205  ALA PRO ASP GLU LEU THR VAL LYS THR LYS ASP GLY VAL          
SEQRES  10 W  205  VAL GLU ILE THR GLY LYS HIS GLU GLU ARG GLN ASP GLU          
SEQRES  11 W  205  HIS GLY TYR ILE SER ARG CYS PHE THR ARG LYS TYR THR          
SEQRES  12 W  205  LEU PRO PRO GLY VAL ASP PRO THR GLN VAL SER SER SER          
SEQRES  13 W  205  LEU SER PRO GLU GLY THR LEU THR VAL GLU ALA PRO MET          
SEQRES  14 W  205  PRO LYS LEU ALA THR GLN SER ASN GLU ILE THR ILE PRO          
SEQRES  15 W  205  VAL THR PHE GLU SER ARG ALA GLN LEU GLY GLY PRO GLU          
SEQRES  16 W  205  ALA ALA LYS SER ASP GLU THR ALA ALA LYS                      
HELIX    1 AA1 SER B   26  ALA B   32  1                                   7    
HELIX    2 AA2 ASP B  149  VAL B  153  5                                   5    
HELIX    3 AA3 HIS A   25  ASP A   30  1                                   6    
HELIX    4 AA4 GLY A   47  TRP A   51  5                                   5    
HELIX    5 AA5 ARG D   12  ARG D   12  5                                   1    
HELIX    6 AA6 ASP D   17  ARG D   20  5                                   4    
HELIX    7 AA7 SER D   26  GLN D   31  1                                   6    
HELIX    8 AA8 ASP D  149  VAL D  153  5                                   5    
HELIX    9 AA9 ARG F   12  ARG F   12  1                                   1    
HELIX   10 AB1 PRO F   18  ASP F   21  1                                   4    
HELIX   11 AB2 SER F   26  ALA F   32  1                                   7    
HELIX   12 AB3 SER H   26  ALA H   32  1                                   7    
HELIX   13 AB4 PRO H   71  ALA H   76  1                                   6    
HELIX   14 AB5 ASP H  149  VAL H  153  5                                   5    
HELIX   15 AB6 SER J   26  ALA J   32  1                                   7    
HELIX   16 AB7 ASP J  149  VAL J  153  5                                   5    
HELIX   17 AB8 PRO L    7  ARG L   12  1                                   6    
HELIX   18 AB9 SER L   26  ALA L   32  1                                   7    
HELIX   19 AC1 PRO L   71  ALA L   76  1                                   6    
HELIX   20 AC2 ASP L  149  VAL L  153  5                                   5    
HELIX   21 AC3 PRO N    7  ARG N   12  5                                   6    
HELIX   22 AC4 ASP N   17  ARG N   20  5                                   4    
HELIX   23 AC5 SER N   26  ALA N   32  1                                   7    
HELIX   24 AC6 ARG P   12  ARG P   12  5                                   1    
HELIX   25 AC7 ASP P   17  ARG P   20  5                                   4    
HELIX   26 AC8 SER P   26  ALA P   32  1                                   7    
HELIX   27 AC9 ARG P   37  GLU P   41  5                                   5    
HELIX   28 AD1 SER P   74  ARG P   79  1                                   6    
HELIX   29 AD2 ASP P  149  VAL P  153  5                                   5    
HELIX   30 AD3 SER R   26  ALA R   32  1                                   7    
HELIX   31 AD4 ARG T   12  ARG T   12  5                                   1    
HELIX   32 AD5 ASP T   17  ARG T   20  5                                   4    
HELIX   33 AD6 SER T   26  ALA T   32  1                                   7    
HELIX   34 AD7 ARG T   37  GLU T   41  5                                   5    
HELIX   35 AD8 PRO T   71  ALA T   76  1                                   6    
HELIX   36 AD9 ASP T  149  VAL T  153  5                                   5    
HELIX   37 AE1 SER V   26  ALA V   32  1                                   7    
HELIX   38 AE2 ARG V   37  GLU V   41  5                                   5    
HELIX   39 AE3 PRO X    7  LEU X   11  5                                   5    
HELIX   40 AE4 SER X   26  GLN X   31  1                                   6    
HELIX   41 AE5 HIS C   25  ASP C   30  1                                   6    
HELIX   42 AE6 HIS E   25  ASP E   30  1                                   6    
HELIX   43 AE7 TYR E   73  SER E   78  1                                   6    
HELIX   44 AE8 HIS G   25  ASP G   30  1                                   6    
HELIX   45 AE9 ALA G  196  ASP G  200  5                                   5    
HELIX   46 AF1 HIS I   25  GLN I   31  1                                   7    
HELIX   47 AF2 LEU I   46  SER I   50  5                                   5    
HELIX   48 AF3 HIS K   25  ASP K   30  1                                   6    
HELIX   49 AF4 HIS M   25  ASP M   30  1                                   6    
HELIX   50 AF5 TYR M   73  SER M   78  1                                   6    
HELIX   51 AF6 ASP M  149  VAL M  153  5                                   5    
HELIX   52 AF7 HIS O   25  ALA O   32  1                                   8    
HELIX   53 AF8 TYR O   73  SER O   78  1                                   6    
HELIX   54 AF9 HIS Q   25  GLN Q   31  1                                   7    
HELIX   55 AG1 TYR Q   73  SER Q   78  1                                   6    
HELIX   56 AG2 LEU S   46  SER S   50  5                                   5    
HELIX   57 AG3 ALA S  196  ASP S  200  5                                   5    
HELIX   58 AG4 HIS W   25  GLN W   31  1                                   7    
SHEET    1 AA1 3 TRP B  95  ASP B 100  0                                        
SHEET    2 AA1 3 THR B 162  ALA B 167 -1  O  ALA B 167   N  TRP B  95           
SHEET    3 AA1 3 SER B 154  LEU B 157 -1  N  SER B 156   O  THR B 164           
SHEET    1 AA2 6 GLU B 108  LYS B 114  0                                        
SHEET    2 AA2 6 VAL B 117  GLU B 125 -1  O  GLU B 119   N  LYS B 112           
SHEET    3 AA2 6 SER B 135  THR B 143 -1  O  TYR B 142   N  VAL B 118           
SHEET    4 AA2 6 ILE E 134  THR E 143 -1  O  SER E 135   N  THR B 139           
SHEET    5 AA2 6 VAL E 117  LYS E 123 -1  N  VAL E 118   O  TYR E 142           
SHEET    6 AA2 6 GLU E 108  LYS E 114 -1  N  LYS E 112   O  GLU E 119           
SHEET    1 AA3 3 TRP A  95  ASP A 100  0                                        
SHEET    2 AA3 3 THR A 162  ALA A 167 -1  O  ALA A 167   N  TRP A  95           
SHEET    3 AA3 3 SER A 154  SER A 156 -1  N  SER A 156   O  THR A 164           
SHEET    1 AA4 3 GLU A 108  LYS A 114  0                                        
SHEET    2 AA4 3 VAL A 117  LYS A 123 -1  O  THR A 121   N  THR A 110           
SHEET    3 AA4 3 CYS A 137  THR A 143 -1  O  TYR A 142   N  VAL A 118           
SHEET    1 AA5 4 ILE A 134  SER A 135  0                                        
SHEET    2 AA5 4 SER D 135  THR D 143 -1  O  THR D 139   N  SER A 135           
SHEET    3 AA5 4 VAL D 117  GLU D 125 -1  N  VAL D 118   O  TYR D 142           
SHEET    4 AA5 4 GLU D 108  LYS D 114 -1  N  THR D 110   O  THR D 121           
SHEET    1 AA6 3 ARG D  94  ASP D 100  0                                        
SHEET    2 AA6 3 THR D 162  PRO D 168 -1  O  ALA D 167   N  TRP D  95           
SHEET    3 AA6 3 SER D 154  LEU D 157 -1  N  SER D 154   O  GLU D 166           
SHEET    1 AA7 3 VAL F  97  ASP F 100  0                                        
SHEET    2 AA7 3 THR F 162  GLU F 166 -1  O  VAL F 165   N  VAL F  97           
SHEET    3 AA7 3 SER F 154  LEU F 157 -1  N  SER F 154   O  GLU F 166           
SHEET    1 AA8 3 GLU F 108  LYS F 114  0                                        
SHEET    2 AA8 3 VAL F 117  LYS F 123 -1  O  GLU F 119   N  LYS F 112           
SHEET    3 AA8 3 CYS F 137  THR F 143 -1  O  TYR F 142   N  VAL F 118           
SHEET    1 AA9 3 TRP H  95  ASP H 100  0                                        
SHEET    2 AA9 3 THR H 162  ALA H 167 -1  O  ALA H 167   N  TRP H  95           
SHEET    3 AA9 3 SER H 154  LEU H 157 -1  N  SER H 154   O  GLU H 166           
SHEET    1 AB1 4 GLU H 108  LYS H 114  0                                        
SHEET    2 AB1 4 VAL H 117  HIS H 124 -1  O  GLU H 119   N  LYS H 112           
SHEET    3 AB1 4 ARG H 136  TYR H 142 -1  O  TYR H 142   N  VAL H 118           
SHEET    4 AB1 4 ILE K 134  SER K 135 -1  O  SER K 135   N  THR H 139           
SHEET    1 AB2 3 TRP J  95  ASP J 100  0                                        
SHEET    2 AB2 3 THR J 162  ALA J 167 -1  O  ALA J 167   N  TRP J  95           
SHEET    3 AB2 3 SER J 154  LEU J 157 -1  N  SER J 154   O  GLU J 166           
SHEET    1 AB3 3 GLU J 108  LYS J 114  0                                        
SHEET    2 AB3 3 VAL J 117  GLU J 125 -1  O  THR J 121   N  THR J 110           
SHEET    3 AB3 3 SER J 135  THR J 143 -1  O  TYR J 142   N  VAL J 118           
SHEET    1 AB4 3 TRP L  95  ASP L 100  0                                        
SHEET    2 AB4 3 THR L 162  ALA L 167 -1  O  ALA L 167   N  TRP L  95           
SHEET    3 AB4 3 SER L 154  LEU L 157 -1  N  SER L 156   O  THR L 164           
SHEET    1 AB5 6 GLU L 108  LYS L 114  0                                        
SHEET    2 AB5 6 VAL L 117  LYS L 123 -1  O  THR L 121   N  THR L 110           
SHEET    3 AB5 6 CYS L 137  THR L 143 -1  O  TYR L 142   N  VAL L 118           
SHEET    4 AB5 6 ILE Q 134  THR Q 143 -1  O  SER Q 135   N  THR L 139           
SHEET    5 AB5 6 VAL Q 117  LYS Q 123 -1  N  VAL Q 118   O  TYR Q 142           
SHEET    6 AB5 6 GLU Q 108  LYS Q 114 -1  N  LYS Q 112   O  GLU Q 119           
SHEET    1 AB6 6 GLU N 108  LYS N 114  0                                        
SHEET    2 AB6 6 VAL N 117  HIS N 124 -1  O  THR N 121   N  THR N 110           
SHEET    3 AB6 6 ARG N 136  THR N 143 -1  O  TYR N 142   N  VAL N 118           
SHEET    4 AB6 6 ARG M 136  THR M 143 -1  O  CYS M 137   N  CYS N 137           
SHEET    5 AB6 6 VAL M 117  LYS M 123 -1  N  VAL M 118   O  TYR M 142           
SHEET    6 AB6 6 GLU M 108  LYS M 114 -1  N  LYS M 112   O  GLU M 119           
SHEET    1 AB7 2 SER N 154  SER N 155  0                                        
SHEET    2 AB7 2 VAL N 165  GLU N 166 -1  O  GLU N 166   N  SER N 154           
SHEET    1 AB8 3 TRP P  95  ASP P 100  0                                        
SHEET    2 AB8 3 THR P 162  ALA P 167 -1  O  ALA P 167   N  TRP P  95           
SHEET    3 AB8 3 SER P 154  LEU P 157 -1  N  SER P 156   O  THR P 164           
SHEET    1 AB9 4 GLU P 108  LYS P 114  0                                        
SHEET    2 AB9 4 VAL P 117  GLU P 125 -1  O  GLU P 119   N  LYS P 112           
SHEET    3 AB9 4 SER P 135  THR P 143 -1  O  TYR P 142   N  VAL P 118           
SHEET    4 AB9 4 ILE O 134  SER O 135 -1  O  SER O 135   N  THR P 139           
SHEET    1 AC1 3 TRP R  95  ASP R 100  0                                        
SHEET    2 AC1 3 THR R 162  ALA R 167 -1  O  ALA R 167   N  TRP R  95           
SHEET    3 AC1 3 SER R 154  LEU R 157 -1  N  SER R 154   O  GLU R 166           
SHEET    1 AC2 6 GLU R 108  LYS R 114  0                                        
SHEET    2 AC2 6 VAL R 117  HIS R 124 -1  O  THR R 121   N  THR R 110           
SHEET    3 AC2 6 ARG R 136  THR R 143 -1  O  ARG R 136   N  HIS R 124           
SHEET    4 AC2 6 ILE W 134  THR W 143 -1  O  SER W 135   N  THR R 139           
SHEET    5 AC2 6 VAL W 117  LYS W 123 -1  N  VAL W 118   O  TYR W 142           
SHEET    6 AC2 6 GLU W 108  LYS W 114 -1  N  THR W 110   O  THR W 121           
SHEET    1 AC3 3 TRP T  95  ASP T 100  0                                        
SHEET    2 AC3 3 THR T 162  ALA T 167 -1  O  ALA T 167   N  TRP T  95           
SHEET    3 AC3 3 SER T 154  LEU T 157 -1  N  SER T 156   O  THR T 164           
SHEET    1 AC4 6 GLU T 108  LYS T 114  0                                        
SHEET    2 AC4 6 VAL T 117  GLU T 125 -1  O  GLU T 119   N  LYS T 112           
SHEET    3 AC4 6 SER T 135  THR T 143 -1  O  TYR T 142   N  VAL T 118           
SHEET    4 AC4 6 ARG S 136  THR S 143 -1  O  THR S 139   N  SER T 135           
SHEET    5 AC4 6 VAL S 117  LYS S 123 -1  N  VAL S 118   O  TYR S 142           
SHEET    6 AC4 6 GLU S 108  THR S 113 -1  N  THR S 110   O  THR S 121           
SHEET    1 AC5 3 TRP V  95  ASP V 100  0                                        
SHEET    2 AC5 3 THR V 162  ALA V 167 -1  O  ALA V 167   N  TRP V  95           
SHEET    3 AC5 3 SER V 154  SER V 158 -1  N  SER V 154   O  GLU V 166           
SHEET    1 AC6 3 GLU V 108  LYS V 114  0                                        
SHEET    2 AC6 3 VAL V 117  HIS V 124 -1  O  GLU V 119   N  LYS V 112           
SHEET    3 AC6 3 ARG V 136  THR V 143 -1  O  TYR V 142   N  VAL V 118           
SHEET    1 AC7 3 TRP X  95  ASP X 100  0                                        
SHEET    2 AC7 3 THR X 162  ALA X 167 -1  O  ALA X 167   N  TRP X  95           
SHEET    3 AC7 3 SER X 154  LEU X 157 -1  N  SER X 154   O  GLU X 166           
SHEET    1 AC8 6 GLU X 108  LYS X 114  0                                        
SHEET    2 AC8 6 VAL X 117  LYS X 123 -1  O  GLU X 119   N  LYS X 112           
SHEET    3 AC8 6 ARG X 136  THR X 143 -1  O  TYR X 142   N  VAL X 118           
SHEET    4 AC8 6 ILE G 134  THR G 143 -1  O  SER G 135   N  THR X 139           
SHEET    5 AC8 6 VAL G 117  LYS G 123 -1  N  VAL G 118   O  TYR G 142           
SHEET    6 AC8 6 GLU G 108  LYS G 114 -1  N  LYS G 112   O  GLU G 119           
SHEET    1 AC9 2 ARG C  96  ASP C 100  0                                        
SHEET    2 AC9 2 THR C 162  GLU C 166 -1  O  LEU C 163   N  LEU C  99           
SHEET    1 AD1 3 GLU C 108  LYS C 114  0                                        
SHEET    2 AD1 3 VAL C 117  LYS C 123 -1  O  GLU C 119   N  LYS C 112           
SHEET    3 AD1 3 CYS C 137  THR C 143 -1  O  TYR C 142   N  VAL C 118           
SHEET    1 AD2 2 ARG E  94  ASP E 100  0                                        
SHEET    2 AD2 2 THR E 162  PRO E 168 -1  O  ALA E 167   N  TRP E  95           
SHEET    1 AD3 3 TRP G  95  ASP G 100  0                                        
SHEET    2 AD3 3 THR G 162  ALA G 167 -1  O  LEU G 163   N  LEU G  99           
SHEET    3 AD3 3 SER G 154  SER G 156 -1  N  SER G 154   O  GLU G 166           
SHEET    1 AD4 3 TRP I  95  ASP I 100  0                                        
SHEET    2 AD4 3 THR I 162  ALA I 167 -1  O  LEU I 163   N  LEU I  99           
SHEET    3 AD4 3 SER I 154  SER I 156 -1  N  SER I 154   O  GLU I 166           
SHEET    1 AD5 3 GLU I 108  LYS I 114  0                                        
SHEET    2 AD5 3 VAL I 117  LYS I 123 -1  O  GLU I 119   N  LYS I 112           
SHEET    3 AD5 3 CYS I 137  THR I 143 -1  O  TYR I 142   N  VAL I 118           
SHEET    1 AD6 2 TRP K  95  ASP K 100  0                                        
SHEET    2 AD6 2 THR K 162  ALA K 167 -1  O  LEU K 163   N  LEU K  99           
SHEET    1 AD7 3 GLU K 108  LYS K 114  0                                        
SHEET    2 AD7 3 VAL K 117  LYS K 123 -1  O  GLU K 119   N  LYS K 112           
SHEET    3 AD7 3 CYS K 137  THR K 143 -1  O  TYR K 142   N  VAL K 118           
SHEET    1 AD8 2 TRP M  95  ASP M 100  0                                        
SHEET    2 AD8 2 THR M 162  ALA M 167 -1  O  ALA M 167   N  TRP M  95           
SHEET    1 AD9 2 TRP O  95  ASP O 100  0                                        
SHEET    2 AD9 2 THR O 162  ALA O 167 -1  O  ALA O 167   N  TRP O  95           
SHEET    1 AE1 3 GLU O 108  LYS O 114  0                                        
SHEET    2 AE1 3 VAL O 117  LYS O 123 -1  O  GLU O 119   N  LYS O 112           
SHEET    3 AE1 3 CYS O 137  THR O 143 -1  O  TYR O 142   N  VAL O 118           
SHEET    1 AE2 2 TRP Q  95  ASP Q 100  0                                        
SHEET    2 AE2 2 THR Q 162  ALA Q 167 -1  O  LEU Q 163   N  LEU Q  99           
SHEET    1 AE3 2 TRP S  95  ASP S 100  0                                        
SHEET    2 AE3 2 THR S 162  ALA S 167 -1  O  ALA S 167   N  TRP S  95           
SHEET    1 AE4 2 TRP U  95  ASP U 100  0                                        
SHEET    2 AE4 2 THR U 162  ALA U 167 -1  O  VAL U 165   N  VAL U  97           
SHEET    1 AE5 3 GLU U 108  LYS U 114  0                                        
SHEET    2 AE5 3 VAL U 117  LYS U 123 -1  O  GLU U 119   N  LYS U 112           
SHEET    3 AE5 3 CYS U 137  THR U 143 -1  O  TYR U 142   N  VAL U 118           
SHEET    1 AE6 3 TRP W  95  ASP W 100  0                                        
SHEET    2 AE6 3 THR W 162  ALA W 167 -1  O  ALA W 167   N  TRP W  95           
SHEET    3 AE6 3 SER W 154  SER W 156 -1  N  SER W 154   O  GLU W 166           
CRYST1  324.700  324.700  198.761  90.00  90.00 120.00 H 3         216          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.003080  0.001778  0.000000        0.00000                         
SCALE2      0.000000  0.003556  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.005031        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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