GenomeNet

Database: PDB
Entry: 6E1H
LinkDB: 6E1H
Original site: 6E1H 
HEADER    MEMBRANE PROTEIN                        09-JUL-18   6E1H              
TITLE     STRUCTURE OF 2:1 HUMAN PTCH1-SHH-N COMPLEX                            
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PROTEIN PATCHED HOMOLOG 1;                                 
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: PTC1;                                                       
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: SONIC HEDGEHOG PROTEIN N-PRODUCT;                          
COMPND   8 CHAIN: C;                                                            
COMPND   9 SYNONYM: SHH,HHG-1,SONIC HEDGEHOG PROTEIN,SHHNC;                     
COMPND  10 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: PTCH1, PTCH;                                                   
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 GENE: SHH;                                                           
SOURCE  14 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  15 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    TUMOR SUPPRESSOR, MEMBRANE PROTEIN                                    
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    X.QI,X.LI                                                             
REVDAT   4   18-DEC-19 6E1H    1       SCALE                                    
REVDAT   3   17-OCT-18 6E1H    1       JRNL                                     
REVDAT   2   05-SEP-18 6E1H    1       JRNL                                     
REVDAT   1   29-AUG-18 6E1H    0                                                
JRNL        AUTH   X.QI,P.SCHMIEGE,E.COUTAVAS,X.LI                              
JRNL        TITL   TWO PATCHED MOLECULES ENGAGE DISTINCT SITES ON HEDGEHOG      
JRNL        TITL 2 YIELDING A SIGNALING-COMPETENT COMPLEX.                      
JRNL        REF    SCIENCE                       V. 362       2018              
JRNL        REFN                   ESSN 1095-9203                               
JRNL        PMID   30139912                                                     
JRNL        DOI    10.1126/SCIENCE.AAS8843                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.50 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.500                          
REMARK   3   NUMBER OF PARTICLES               : 77712                          
REMARK   3   CTF CORRECTION METHOD             : NONE                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6E1H COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 10-JUL-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000235566.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : PTC                               
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : DARK FIELD                     
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 1.60                           
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, B                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     SER A     3                                                      
REMARK 465     ALA A     4                                                      
REMARK 465     GLY A     5                                                      
REMARK 465     ASN A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     ALA A     8                                                      
REMARK 465     GLU A     9                                                      
REMARK 465     PRO A    10                                                      
REMARK 465     GLN A    11                                                      
REMARK 465     ASP A    12                                                      
REMARK 465     ARG A    13                                                      
REMARK 465     GLY A    14                                                      
REMARK 465     GLY A    15                                                      
REMARK 465     GLY A    16                                                      
REMARK 465     GLY A    17                                                      
REMARK 465     SER A    18                                                      
REMARK 465     GLY A    19                                                      
REMARK 465     CYS A    20                                                      
REMARK 465     ILE A    21                                                      
REMARK 465     GLY A    22                                                      
REMARK 465     ALA A    23                                                      
REMARK 465     PRO A    24                                                      
REMARK 465     GLY A    25                                                      
REMARK 465     ARG A    26                                                      
REMARK 465     PRO A    27                                                      
REMARK 465     ALA A    28                                                      
REMARK 465     GLY A    29                                                      
REMARK 465     GLY A    30                                                      
REMARK 465     GLY A    31                                                      
REMARK 465     ARG A    32                                                      
REMARK 465     ARG A    33                                                      
REMARK 465     ARG A    34                                                      
REMARK 465     ARG A    35                                                      
REMARK 465     THR A    36                                                      
REMARK 465     GLY A    37                                                      
REMARK 465     GLY A    38                                                      
REMARK 465     LEU A    39                                                      
REMARK 465     ARG A    40                                                      
REMARK 465     ARG A    41                                                      
REMARK 465     ALA A    42                                                      
REMARK 465     ALA A    43                                                      
REMARK 465     ALA A    44                                                      
REMARK 465     PRO A    45                                                      
REMARK 465     ASP A    46                                                      
REMARK 465     ARG A    47                                                      
REMARK 465     ASP A    48                                                      
REMARK 465     TYR A    49                                                      
REMARK 465     LEU A    50                                                      
REMARK 465     HIS A    51                                                      
REMARK 465     ARG A    52                                                      
REMARK 465     PRO A    53                                                      
REMARK 465     SER A    54                                                      
REMARK 465     TYR A    55                                                      
REMARK 465     CYS A    56                                                      
REMARK 465     ASP A    57                                                      
REMARK 465     ALA A    58                                                      
REMARK 465     ALA A    59                                                      
REMARK 465     PHE A    60                                                      
REMARK 465     ALA A    61                                                      
REMARK 465     LEU A    62                                                      
REMARK 465     GLU A    63                                                      
REMARK 465     GLN A    64                                                      
REMARK 465     ILE A    65                                                      
REMARK 465     SER A    66                                                      
REMARK 465     LYS A    67                                                      
REMARK 465     GLY A    68                                                      
REMARK 465     LYS A    69                                                      
REMARK 465     ALA A    70                                                      
REMARK 465     THR A    71                                                      
REMARK 465     GLY A    72                                                      
REMARK 465     ARG A    73                                                      
REMARK 465     LYS A    74                                                      
REMARK 465     ALA A    75                                                      
REMARK 465     LEU A   608                                                      
REMARK 465     ASP A   609                                                      
REMARK 465     ILE A   610                                                      
REMARK 465     PHE A   611                                                      
REMARK 465     CYS A   612                                                      
REMARK 465     CYS A   613                                                      
REMARK 465     PHE A   614                                                      
REMARK 465     THR A   615                                                      
REMARK 465     SER A   616                                                      
REMARK 465     PRO A   617                                                      
REMARK 465     CYS A   618                                                      
REMARK 465     VAL A   619                                                      
REMARK 465     SER A   620                                                      
REMARK 465     ARG A   621                                                      
REMARK 465     VAL A   622                                                      
REMARK 465     ILE A   623                                                      
REMARK 465     GLN A   624                                                      
REMARK 465     VAL A   625                                                      
REMARK 465     GLU A   626                                                      
REMARK 465     PRO A   627                                                      
REMARK 465     GLN A   628                                                      
REMARK 465     ALA A   629                                                      
REMARK 465     TYR A   630                                                      
REMARK 465     THR A   631                                                      
REMARK 465     ASP A   632                                                      
REMARK 465     THR A   633                                                      
REMARK 465     HIS A   634                                                      
REMARK 465     ASP A   635                                                      
REMARK 465     ASN A   636                                                      
REMARK 465     THR A   637                                                      
REMARK 465     ARG A   638                                                      
REMARK 465     TYR A   639                                                      
REMARK 465     SER A   640                                                      
REMARK 465     PRO A   641                                                      
REMARK 465     PRO A   642                                                      
REMARK 465     PRO A   643                                                      
REMARK 465     PRO A   644                                                      
REMARK 465     TYR A   645                                                      
REMARK 465     SER A   646                                                      
REMARK 465     SER A   647                                                      
REMARK 465     HIS A   648                                                      
REMARK 465     SER A   649                                                      
REMARK 465     PHE A   650                                                      
REMARK 465     ALA A   651                                                      
REMARK 465     HIS A   652                                                      
REMARK 465     GLU A   653                                                      
REMARK 465     THR A   654                                                      
REMARK 465     GLN A   655                                                      
REMARK 465     ILE A   656                                                      
REMARK 465     THR A   657                                                      
REMARK 465     MET A   658                                                      
REMARK 465     GLN A   659                                                      
REMARK 465     SER A   660                                                      
REMARK 465     THR A   661                                                      
REMARK 465     VAL A   662                                                      
REMARK 465     GLN A   663                                                      
REMARK 465     LEU A   664                                                      
REMARK 465     ARG A   665                                                      
REMARK 465     THR A   666                                                      
REMARK 465     GLU A   667                                                      
REMARK 465     TYR A   668                                                      
REMARK 465     ASP A   669                                                      
REMARK 465     PRO A   670                                                      
REMARK 465     HIS A   671                                                      
REMARK 465     THR A   672                                                      
REMARK 465     HIS A   673                                                      
REMARK 465     VAL A   674                                                      
REMARK 465     TYR A   675                                                      
REMARK 465     TYR A   676                                                      
REMARK 465     THR A   677                                                      
REMARK 465     THR A   678                                                      
REMARK 465     ALA A   679                                                      
REMARK 465     GLU A   680                                                      
REMARK 465     PRO A   681                                                      
REMARK 465     ARG A   682                                                      
REMARK 465     SER A   683                                                      
REMARK 465     GLU A   684                                                      
REMARK 465     ILE A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     VAL A   687                                                      
REMARK 465     GLN A   688                                                      
REMARK 465     PRO A   689                                                      
REMARK 465     VAL A   690                                                      
REMARK 465     THR A   691                                                      
REMARK 465     VAL A   692                                                      
REMARK 465     THR A   693                                                      
REMARK 465     GLN A   694                                                      
REMARK 465     ASP A   695                                                      
REMARK 465     THR A   696                                                      
REMARK 465     LEU A   697                                                      
REMARK 465     SER A   698                                                      
REMARK 465     CYS A   699                                                      
REMARK 465     GLN A   700                                                      
REMARK 465     SER A   701                                                      
REMARK 465     PRO A   702                                                      
REMARK 465     GLU A   703                                                      
REMARK 465     SER A   704                                                      
REMARK 465     THR A   705                                                      
REMARK 465     SER A   706                                                      
REMARK 465     SER A   707                                                      
REMARK 465     THR A   708                                                      
REMARK 465     ARG A   709                                                      
REMARK 465     ASP A   710                                                      
REMARK 465     LEU A   711                                                      
REMARK 465     LEU A   712                                                      
REMARK 465     SER A   713                                                      
REMARK 465     GLN A   714                                                      
REMARK 465     PHE A   715                                                      
REMARK 465     SER A   716                                                      
REMARK 465     ASP A   717                                                      
REMARK 465     SER A   718                                                      
REMARK 465     SER A   719                                                      
REMARK 465     LEU A   720                                                      
REMARK 465     HIS A   721                                                      
REMARK 465     CYS A   722                                                      
REMARK 465     LEU A   723                                                      
REMARK 465     GLU A   724                                                      
REMARK 465     PRO A   725                                                      
REMARK 465     PRO A   726                                                      
REMARK 465     CYS A   727                                                      
REMARK 465     THR A   728                                                      
REMARK 465     LYS A   729                                                      
REMARK 465     TRP A   730                                                      
REMARK 465     PHE A  1177                                                      
REMARK 465     PHE A  1178                                                      
REMARK 465     GLY A  1179                                                      
REMARK 465     PRO A  1180                                                      
REMARK 465     TYR A  1181                                                      
REMARK 465     PRO A  1182                                                      
REMARK 465     GLU A  1183                                                      
REMARK 465     VAL A  1184                                                      
REMARK 465     SER A  1185                                                      
REMARK 465     PRO A  1186                                                      
REMARK 465     ALA A  1187                                                      
REMARK 465     ASN A  1188                                                      
REMARK 465     GLY A  1189                                                      
REMARK 465     LEU A  1190                                                      
REMARK 465     ASN A  1191                                                      
REMARK 465     ARG A  1192                                                      
REMARK 465     LEU A  1193                                                      
REMARK 465     PRO A  1194                                                      
REMARK 465     THR A  1195                                                      
REMARK 465     PRO A  1196                                                      
REMARK 465     SER A  1197                                                      
REMARK 465     PRO A  1198                                                      
REMARK 465     GLU A  1199                                                      
REMARK 465     PRO A  1200                                                      
REMARK 465     PRO A  1201                                                      
REMARK 465     PRO A  1202                                                      
REMARK 465     SER A  1203                                                      
REMARK 465     VAL A  1204                                                      
REMARK 465     VAL A  1205                                                      
REMARK 465     ARG A  1206                                                      
REMARK 465     PHE A  1207                                                      
REMARK 465     ALA A  1208                                                      
REMARK 465     MET A  1209                                                      
REMARK 465     PRO A  1210                                                      
REMARK 465     PRO A  1211                                                      
REMARK 465     GLY A  1212                                                      
REMARK 465     HIS A  1213                                                      
REMARK 465     THR A  1214                                                      
REMARK 465     HIS A  1215                                                      
REMARK 465     SER A  1216                                                      
REMARK 465     GLY A  1217                                                      
REMARK 465     SER A  1218                                                      
REMARK 465     ASP A  1219                                                      
REMARK 465     SER A  1220                                                      
REMARK 465     SER A  1221                                                      
REMARK 465     ASP A  1222                                                      
REMARK 465     SER A  1223                                                      
REMARK 465     GLU A  1224                                                      
REMARK 465     TYR A  1225                                                      
REMARK 465     SER A  1226                                                      
REMARK 465     SER A  1227                                                      
REMARK 465     GLN A  1228                                                      
REMARK 465     THR A  1229                                                      
REMARK 465     THR A  1230                                                      
REMARK 465     VAL A  1231                                                      
REMARK 465     SER A  1232                                                      
REMARK 465     GLY A  1233                                                      
REMARK 465     LEU A  1234                                                      
REMARK 465     SER A  1235                                                      
REMARK 465     GLU A  1236                                                      
REMARK 465     GLU A  1237                                                      
REMARK 465     LEU A  1238                                                      
REMARK 465     ARG A  1239                                                      
REMARK 465     HIS A  1240                                                      
REMARK 465     TYR A  1241                                                      
REMARK 465     GLU A  1242                                                      
REMARK 465     ALA A  1243                                                      
REMARK 465     GLN A  1244                                                      
REMARK 465     GLN A  1245                                                      
REMARK 465     GLY A  1246                                                      
REMARK 465     ALA A  1247                                                      
REMARK 465     GLY A  1248                                                      
REMARK 465     GLY A  1249                                                      
REMARK 465     PRO A  1250                                                      
REMARK 465     ALA A  1251                                                      
REMARK 465     HIS A  1252                                                      
REMARK 465     GLN A  1253                                                      
REMARK 465     VAL A  1254                                                      
REMARK 465     ILE A  1255                                                      
REMARK 465     VAL A  1256                                                      
REMARK 465     GLU A  1257                                                      
REMARK 465     ALA A  1258                                                      
REMARK 465     THR A  1259                                                      
REMARK 465     GLU A  1260                                                      
REMARK 465     ASN A  1261                                                      
REMARK 465     PRO A  1262                                                      
REMARK 465     VAL A  1263                                                      
REMARK 465     PHE A  1264                                                      
REMARK 465     ALA A  1265                                                      
REMARK 465     HIS A  1266                                                      
REMARK 465     SER A  1267                                                      
REMARK 465     THR A  1268                                                      
REMARK 465     VAL A  1269                                                      
REMARK 465     VAL A  1270                                                      
REMARK 465     HIS A  1271                                                      
REMARK 465     PRO A  1272                                                      
REMARK 465     GLU A  1273                                                      
REMARK 465     SER A  1274                                                      
REMARK 465     ARG A  1275                                                      
REMARK 465     HIS A  1276                                                      
REMARK 465     HIS A  1277                                                      
REMARK 465     PRO A  1278                                                      
REMARK 465     PRO A  1279                                                      
REMARK 465     SER A  1280                                                      
REMARK 465     ASN A  1281                                                      
REMARK 465     PRO A  1282                                                      
REMARK 465     ARG A  1283                                                      
REMARK 465     GLN A  1284                                                      
REMARK 465     GLN A  1285                                                      
REMARK 465     PRO A  1286                                                      
REMARK 465     HIS A  1287                                                      
REMARK 465     LEU A  1288                                                      
REMARK 465     ASP A  1289                                                      
REMARK 465     SER A  1290                                                      
REMARK 465     GLY A  1291                                                      
REMARK 465     SER A  1292                                                      
REMARK 465     LEU A  1293                                                      
REMARK 465     PRO A  1294                                                      
REMARK 465     PRO A  1295                                                      
REMARK 465     GLY A  1296                                                      
REMARK 465     ARG A  1297                                                      
REMARK 465     GLN A  1298                                                      
REMARK 465     GLY A  1299                                                      
REMARK 465     GLN A  1300                                                      
REMARK 465     GLN A  1301                                                      
REMARK 465     PRO A  1302                                                      
REMARK 465     ARG A  1303                                                      
REMARK 465     ARG A  1304                                                      
REMARK 465     ASP A  1305                                                      
REMARK 465     PRO A  1306                                                      
REMARK 465     PRO A  1307                                                      
REMARK 465     ARG A  1308                                                      
REMARK 465     GLU A  1309                                                      
REMARK 465     GLY A  1310                                                      
REMARK 465     LEU A  1311                                                      
REMARK 465     TRP A  1312                                                      
REMARK 465     PRO A  1313                                                      
REMARK 465     PRO A  1314                                                      
REMARK 465     PRO A  1315                                                      
REMARK 465     TYR A  1316                                                      
REMARK 465     ARG A  1317                                                      
REMARK 465     PRO A  1318                                                      
REMARK 465     ARG A  1319                                                      
REMARK 465     ARG A  1320                                                      
REMARK 465     ASP A  1321                                                      
REMARK 465     ALA A  1322                                                      
REMARK 465     PHE A  1323                                                      
REMARK 465     GLU A  1324                                                      
REMARK 465     ILE A  1325                                                      
REMARK 465     SER A  1326                                                      
REMARK 465     THR A  1327                                                      
REMARK 465     GLU A  1328                                                      
REMARK 465     GLY A  1329                                                      
REMARK 465     HIS A  1330                                                      
REMARK 465     SER A  1331                                                      
REMARK 465     GLY A  1332                                                      
REMARK 465     PRO A  1333                                                      
REMARK 465     SER A  1334                                                      
REMARK 465     ASN A  1335                                                      
REMARK 465     ARG A  1336                                                      
REMARK 465     ALA A  1337                                                      
REMARK 465     ARG A  1338                                                      
REMARK 465     TRP A  1339                                                      
REMARK 465     GLY A  1340                                                      
REMARK 465     PRO A  1341                                                      
REMARK 465     ARG A  1342                                                      
REMARK 465     GLY A  1343                                                      
REMARK 465     ALA A  1344                                                      
REMARK 465     ARG A  1345                                                      
REMARK 465     SER A  1346                                                      
REMARK 465     HIS A  1347                                                      
REMARK 465     ASN A  1348                                                      
REMARK 465     PRO A  1349                                                      
REMARK 465     ARG A  1350                                                      
REMARK 465     ASN A  1351                                                      
REMARK 465     PRO A  1352                                                      
REMARK 465     ALA A  1353                                                      
REMARK 465     SER A  1354                                                      
REMARK 465     THR A  1355                                                      
REMARK 465     ALA A  1356                                                      
REMARK 465     MET A  1357                                                      
REMARK 465     GLY A  1358                                                      
REMARK 465     SER A  1359                                                      
REMARK 465     SER A  1360                                                      
REMARK 465     VAL A  1361                                                      
REMARK 465     PRO A  1362                                                      
REMARK 465     GLY A  1363                                                      
REMARK 465     TYR A  1364                                                      
REMARK 465     CYS A  1365                                                      
REMARK 465     GLN A  1366                                                      
REMARK 465     PRO A  1367                                                      
REMARK 465     ILE A  1368                                                      
REMARK 465     THR A  1369                                                      
REMARK 465     THR A  1370                                                      
REMARK 465     VAL A  1371                                                      
REMARK 465     THR A  1372                                                      
REMARK 465     ALA A  1373                                                      
REMARK 465     SER A  1374                                                      
REMARK 465     ALA A  1375                                                      
REMARK 465     SER A  1376                                                      
REMARK 465     VAL A  1377                                                      
REMARK 465     THR A  1378                                                      
REMARK 465     VAL A  1379                                                      
REMARK 465     ALA A  1380                                                      
REMARK 465     VAL A  1381                                                      
REMARK 465     HIS A  1382                                                      
REMARK 465     PRO A  1383                                                      
REMARK 465     PRO A  1384                                                      
REMARK 465     PRO A  1385                                                      
REMARK 465     VAL A  1386                                                      
REMARK 465     PRO A  1387                                                      
REMARK 465     GLY A  1388                                                      
REMARK 465     PRO A  1389                                                      
REMARK 465     GLY A  1390                                                      
REMARK 465     ARG A  1391                                                      
REMARK 465     ASN A  1392                                                      
REMARK 465     PRO A  1393                                                      
REMARK 465     ARG A  1394                                                      
REMARK 465     GLY A  1395                                                      
REMARK 465     GLY A  1396                                                      
REMARK 465     LEU A  1397                                                      
REMARK 465     CYS A  1398                                                      
REMARK 465     PRO A  1399                                                      
REMARK 465     GLY A  1400                                                      
REMARK 465     TYR A  1401                                                      
REMARK 465     PRO A  1402                                                      
REMARK 465     GLU A  1403                                                      
REMARK 465     THR A  1404                                                      
REMARK 465     ASP A  1405                                                      
REMARK 465     HIS A  1406                                                      
REMARK 465     GLY A  1407                                                      
REMARK 465     LEU A  1408                                                      
REMARK 465     PHE A  1409                                                      
REMARK 465     GLU A  1410                                                      
REMARK 465     ASP A  1411                                                      
REMARK 465     PRO A  1412                                                      
REMARK 465     HIS A  1413                                                      
REMARK 465     VAL A  1414                                                      
REMARK 465     PRO A  1415                                                      
REMARK 465     PHE A  1416                                                      
REMARK 465     HIS A  1417                                                      
REMARK 465     VAL A  1418                                                      
REMARK 465     ARG A  1419                                                      
REMARK 465     CYS A  1420                                                      
REMARK 465     GLU A  1421                                                      
REMARK 465     ARG A  1422                                                      
REMARK 465     ARG A  1423                                                      
REMARK 465     ASP A  1424                                                      
REMARK 465     SER A  1425                                                      
REMARK 465     LYS A  1426                                                      
REMARK 465     VAL A  1427                                                      
REMARK 465     GLU A  1428                                                      
REMARK 465     VAL A  1429                                                      
REMARK 465     ILE A  1430                                                      
REMARK 465     GLU A  1431                                                      
REMARK 465     LEU A  1432                                                      
REMARK 465     GLN A  1433                                                      
REMARK 465     ASP A  1434                                                      
REMARK 465     VAL A  1435                                                      
REMARK 465     GLU A  1436                                                      
REMARK 465     CYS A  1437                                                      
REMARK 465     GLU A  1438                                                      
REMARK 465     GLU A  1439                                                      
REMARK 465     ARG A  1440                                                      
REMARK 465     PRO A  1441                                                      
REMARK 465     ARG A  1442                                                      
REMARK 465     GLY A  1443                                                      
REMARK 465     SER A  1444                                                      
REMARK 465     SER A  1445                                                      
REMARK 465     SER A  1446                                                      
REMARK 465     ASN A  1447                                                      
REMARK 465     GLU C   188                                                      
REMARK 465     ASN C   189                                                      
REMARK 465     SER C   190                                                      
REMARK 465     VAL C   191                                                      
REMARK 465     ALA C   192                                                      
REMARK 465     ALA C   193                                                      
REMARK 465     LYS C   194                                                      
REMARK 465     SER C   195                                                      
REMARK 465     GLY C   196                                                      
REMARK 465     GLY C   197                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     SER B     3                                                      
REMARK 465     ALA B     4                                                      
REMARK 465     GLY B     5                                                      
REMARK 465     ASN B     6                                                      
REMARK 465     ALA B     7                                                      
REMARK 465     ALA B     8                                                      
REMARK 465     GLU B     9                                                      
REMARK 465     PRO B    10                                                      
REMARK 465     GLN B    11                                                      
REMARK 465     ASP B    12                                                      
REMARK 465     ARG B    13                                                      
REMARK 465     GLY B    14                                                      
REMARK 465     GLY B    15                                                      
REMARK 465     GLY B    16                                                      
REMARK 465     GLY B    17                                                      
REMARK 465     SER B    18                                                      
REMARK 465     GLY B    19                                                      
REMARK 465     CYS B    20                                                      
REMARK 465     ILE B    21                                                      
REMARK 465     GLY B    22                                                      
REMARK 465     ALA B    23                                                      
REMARK 465     PRO B    24                                                      
REMARK 465     GLY B    25                                                      
REMARK 465     ARG B    26                                                      
REMARK 465     PRO B    27                                                      
REMARK 465     ALA B    28                                                      
REMARK 465     GLY B    29                                                      
REMARK 465     GLY B    30                                                      
REMARK 465     GLY B    31                                                      
REMARK 465     ARG B    32                                                      
REMARK 465     ARG B    33                                                      
REMARK 465     ARG B    34                                                      
REMARK 465     ARG B    35                                                      
REMARK 465     THR B    36                                                      
REMARK 465     GLY B    37                                                      
REMARK 465     GLY B    38                                                      
REMARK 465     LEU B    39                                                      
REMARK 465     ARG B    40                                                      
REMARK 465     ARG B    41                                                      
REMARK 465     ALA B    42                                                      
REMARK 465     ALA B    43                                                      
REMARK 465     ALA B    44                                                      
REMARK 465     PRO B    45                                                      
REMARK 465     ASP B    46                                                      
REMARK 465     ARG B    47                                                      
REMARK 465     ASP B    48                                                      
REMARK 465     TYR B    49                                                      
REMARK 465     LEU B    50                                                      
REMARK 465     HIS B    51                                                      
REMARK 465     ARG B    52                                                      
REMARK 465     PRO B    53                                                      
REMARK 465     SER B    54                                                      
REMARK 465     TYR B    55                                                      
REMARK 465     CYS B    56                                                      
REMARK 465     ASP B    57                                                      
REMARK 465     ALA B    58                                                      
REMARK 465     ALA B    59                                                      
REMARK 465     PHE B    60                                                      
REMARK 465     ALA B    61                                                      
REMARK 465     LEU B    62                                                      
REMARK 465     GLU B    63                                                      
REMARK 465     GLN B    64                                                      
REMARK 465     ILE B    65                                                      
REMARK 465     SER B    66                                                      
REMARK 465     LYS B    67                                                      
REMARK 465     GLY B    68                                                      
REMARK 465     LYS B    69                                                      
REMARK 465     ALA B    70                                                      
REMARK 465     THR B    71                                                      
REMARK 465     GLY B    72                                                      
REMARK 465     ARG B    73                                                      
REMARK 465     LYS B    74                                                      
REMARK 465     ALA B    75                                                      
REMARK 465     LEU B   608                                                      
REMARK 465     ASP B   609                                                      
REMARK 465     ILE B   610                                                      
REMARK 465     PHE B   611                                                      
REMARK 465     CYS B   612                                                      
REMARK 465     CYS B   613                                                      
REMARK 465     PHE B   614                                                      
REMARK 465     THR B   615                                                      
REMARK 465     SER B   616                                                      
REMARK 465     PRO B   617                                                      
REMARK 465     CYS B   618                                                      
REMARK 465     VAL B   619                                                      
REMARK 465     SER B   620                                                      
REMARK 465     ARG B   621                                                      
REMARK 465     VAL B   622                                                      
REMARK 465     ILE B   623                                                      
REMARK 465     GLN B   624                                                      
REMARK 465     VAL B   625                                                      
REMARK 465     GLU B   626                                                      
REMARK 465     PRO B   627                                                      
REMARK 465     GLN B   628                                                      
REMARK 465     ALA B   629                                                      
REMARK 465     TYR B   630                                                      
REMARK 465     THR B   631                                                      
REMARK 465     ASP B   632                                                      
REMARK 465     THR B   633                                                      
REMARK 465     HIS B   634                                                      
REMARK 465     ASP B   635                                                      
REMARK 465     ASN B   636                                                      
REMARK 465     THR B   637                                                      
REMARK 465     ARG B   638                                                      
REMARK 465     TYR B   639                                                      
REMARK 465     SER B   640                                                      
REMARK 465     PRO B   641                                                      
REMARK 465     PRO B   642                                                      
REMARK 465     PRO B   643                                                      
REMARK 465     PRO B   644                                                      
REMARK 465     TYR B   645                                                      
REMARK 465     SER B   646                                                      
REMARK 465     SER B   647                                                      
REMARK 465     HIS B   648                                                      
REMARK 465     SER B   649                                                      
REMARK 465     PHE B   650                                                      
REMARK 465     ALA B   651                                                      
REMARK 465     HIS B   652                                                      
REMARK 465     GLU B   653                                                      
REMARK 465     THR B   654                                                      
REMARK 465     GLN B   655                                                      
REMARK 465     ILE B   656                                                      
REMARK 465     THR B   657                                                      
REMARK 465     MET B   658                                                      
REMARK 465     GLN B   659                                                      
REMARK 465     SER B   660                                                      
REMARK 465     THR B   661                                                      
REMARK 465     VAL B   662                                                      
REMARK 465     GLN B   663                                                      
REMARK 465     LEU B   664                                                      
REMARK 465     ARG B   665                                                      
REMARK 465     THR B   666                                                      
REMARK 465     GLU B   667                                                      
REMARK 465     TYR B   668                                                      
REMARK 465     ASP B   669                                                      
REMARK 465     PRO B   670                                                      
REMARK 465     HIS B   671                                                      
REMARK 465     THR B   672                                                      
REMARK 465     HIS B   673                                                      
REMARK 465     VAL B   674                                                      
REMARK 465     TYR B   675                                                      
REMARK 465     TYR B   676                                                      
REMARK 465     THR B   677                                                      
REMARK 465     THR B   678                                                      
REMARK 465     ALA B   679                                                      
REMARK 465     GLU B   680                                                      
REMARK 465     PRO B   681                                                      
REMARK 465     ARG B   682                                                      
REMARK 465     SER B   683                                                      
REMARK 465     GLU B   684                                                      
REMARK 465     ILE B   685                                                      
REMARK 465     SER B   686                                                      
REMARK 465     VAL B   687                                                      
REMARK 465     GLN B   688                                                      
REMARK 465     PRO B   689                                                      
REMARK 465     VAL B   690                                                      
REMARK 465     THR B   691                                                      
REMARK 465     VAL B   692                                                      
REMARK 465     THR B   693                                                      
REMARK 465     GLN B   694                                                      
REMARK 465     ASP B   695                                                      
REMARK 465     THR B   696                                                      
REMARK 465     LEU B   697                                                      
REMARK 465     SER B   698                                                      
REMARK 465     CYS B   699                                                      
REMARK 465     GLN B   700                                                      
REMARK 465     SER B   701                                                      
REMARK 465     PRO B   702                                                      
REMARK 465     GLU B   703                                                      
REMARK 465     SER B   704                                                      
REMARK 465     THR B   705                                                      
REMARK 465     SER B   706                                                      
REMARK 465     SER B   707                                                      
REMARK 465     THR B   708                                                      
REMARK 465     ARG B   709                                                      
REMARK 465     ASP B   710                                                      
REMARK 465     LEU B   711                                                      
REMARK 465     LEU B   712                                                      
REMARK 465     SER B   713                                                      
REMARK 465     GLN B   714                                                      
REMARK 465     PHE B   715                                                      
REMARK 465     SER B   716                                                      
REMARK 465     ASP B   717                                                      
REMARK 465     SER B   718                                                      
REMARK 465     SER B   719                                                      
REMARK 465     LEU B   720                                                      
REMARK 465     HIS B   721                                                      
REMARK 465     CYS B   722                                                      
REMARK 465     LEU B   723                                                      
REMARK 465     GLU B   724                                                      
REMARK 465     PRO B   725                                                      
REMARK 465     PRO B   726                                                      
REMARK 465     CYS B   727                                                      
REMARK 465     THR B   728                                                      
REMARK 465     LYS B   729                                                      
REMARK 465     TRP B   730                                                      
REMARK 465     PHE B  1177                                                      
REMARK 465     PHE B  1178                                                      
REMARK 465     GLY B  1179                                                      
REMARK 465     PRO B  1180                                                      
REMARK 465     TYR B  1181                                                      
REMARK 465     PRO B  1182                                                      
REMARK 465     GLU B  1183                                                      
REMARK 465     VAL B  1184                                                      
REMARK 465     SER B  1185                                                      
REMARK 465     PRO B  1186                                                      
REMARK 465     ALA B  1187                                                      
REMARK 465     ASN B  1188                                                      
REMARK 465     GLY B  1189                                                      
REMARK 465     LEU B  1190                                                      
REMARK 465     ASN B  1191                                                      
REMARK 465     ARG B  1192                                                      
REMARK 465     LEU B  1193                                                      
REMARK 465     PRO B  1194                                                      
REMARK 465     THR B  1195                                                      
REMARK 465     PRO B  1196                                                      
REMARK 465     SER B  1197                                                      
REMARK 465     PRO B  1198                                                      
REMARK 465     GLU B  1199                                                      
REMARK 465     PRO B  1200                                                      
REMARK 465     PRO B  1201                                                      
REMARK 465     PRO B  1202                                                      
REMARK 465     SER B  1203                                                      
REMARK 465     VAL B  1204                                                      
REMARK 465     VAL B  1205                                                      
REMARK 465     ARG B  1206                                                      
REMARK 465     PHE B  1207                                                      
REMARK 465     ALA B  1208                                                      
REMARK 465     MET B  1209                                                      
REMARK 465     PRO B  1210                                                      
REMARK 465     PRO B  1211                                                      
REMARK 465     GLY B  1212                                                      
REMARK 465     HIS B  1213                                                      
REMARK 465     THR B  1214                                                      
REMARK 465     HIS B  1215                                                      
REMARK 465     SER B  1216                                                      
REMARK 465     GLY B  1217                                                      
REMARK 465     SER B  1218                                                      
REMARK 465     ASP B  1219                                                      
REMARK 465     SER B  1220                                                      
REMARK 465     SER B  1221                                                      
REMARK 465     ASP B  1222                                                      
REMARK 465     SER B  1223                                                      
REMARK 465     GLU B  1224                                                      
REMARK 465     TYR B  1225                                                      
REMARK 465     SER B  1226                                                      
REMARK 465     SER B  1227                                                      
REMARK 465     GLN B  1228                                                      
REMARK 465     THR B  1229                                                      
REMARK 465     THR B  1230                                                      
REMARK 465     VAL B  1231                                                      
REMARK 465     SER B  1232                                                      
REMARK 465     GLY B  1233                                                      
REMARK 465     LEU B  1234                                                      
REMARK 465     SER B  1235                                                      
REMARK 465     GLU B  1236                                                      
REMARK 465     GLU B  1237                                                      
REMARK 465     LEU B  1238                                                      
REMARK 465     ARG B  1239                                                      
REMARK 465     HIS B  1240                                                      
REMARK 465     TYR B  1241                                                      
REMARK 465     GLU B  1242                                                      
REMARK 465     ALA B  1243                                                      
REMARK 465     GLN B  1244                                                      
REMARK 465     GLN B  1245                                                      
REMARK 465     GLY B  1246                                                      
REMARK 465     ALA B  1247                                                      
REMARK 465     GLY B  1248                                                      
REMARK 465     GLY B  1249                                                      
REMARK 465     PRO B  1250                                                      
REMARK 465     ALA B  1251                                                      
REMARK 465     HIS B  1252                                                      
REMARK 465     GLN B  1253                                                      
REMARK 465     VAL B  1254                                                      
REMARK 465     ILE B  1255                                                      
REMARK 465     VAL B  1256                                                      
REMARK 465     GLU B  1257                                                      
REMARK 465     ALA B  1258                                                      
REMARK 465     THR B  1259                                                      
REMARK 465     GLU B  1260                                                      
REMARK 465     ASN B  1261                                                      
REMARK 465     PRO B  1262                                                      
REMARK 465     VAL B  1263                                                      
REMARK 465     PHE B  1264                                                      
REMARK 465     ALA B  1265                                                      
REMARK 465     HIS B  1266                                                      
REMARK 465     SER B  1267                                                      
REMARK 465     THR B  1268                                                      
REMARK 465     VAL B  1269                                                      
REMARK 465     VAL B  1270                                                      
REMARK 465     HIS B  1271                                                      
REMARK 465     PRO B  1272                                                      
REMARK 465     GLU B  1273                                                      
REMARK 465     SER B  1274                                                      
REMARK 465     ARG B  1275                                                      
REMARK 465     HIS B  1276                                                      
REMARK 465     HIS B  1277                                                      
REMARK 465     PRO B  1278                                                      
REMARK 465     PRO B  1279                                                      
REMARK 465     SER B  1280                                                      
REMARK 465     ASN B  1281                                                      
REMARK 465     PRO B  1282                                                      
REMARK 465     ARG B  1283                                                      
REMARK 465     GLN B  1284                                                      
REMARK 465     GLN B  1285                                                      
REMARK 465     PRO B  1286                                                      
REMARK 465     HIS B  1287                                                      
REMARK 465     LEU B  1288                                                      
REMARK 465     ASP B  1289                                                      
REMARK 465     SER B  1290                                                      
REMARK 465     GLY B  1291                                                      
REMARK 465     SER B  1292                                                      
REMARK 465     LEU B  1293                                                      
REMARK 465     PRO B  1294                                                      
REMARK 465     PRO B  1295                                                      
REMARK 465     GLY B  1296                                                      
REMARK 465     ARG B  1297                                                      
REMARK 465     GLN B  1298                                                      
REMARK 465     GLY B  1299                                                      
REMARK 465     GLN B  1300                                                      
REMARK 465     GLN B  1301                                                      
REMARK 465     PRO B  1302                                                      
REMARK 465     ARG B  1303                                                      
REMARK 465     ARG B  1304                                                      
REMARK 465     ASP B  1305                                                      
REMARK 465     PRO B  1306                                                      
REMARK 465     PRO B  1307                                                      
REMARK 465     ARG B  1308                                                      
REMARK 465     GLU B  1309                                                      
REMARK 465     GLY B  1310                                                      
REMARK 465     LEU B  1311                                                      
REMARK 465     TRP B  1312                                                      
REMARK 465     PRO B  1313                                                      
REMARK 465     PRO B  1314                                                      
REMARK 465     PRO B  1315                                                      
REMARK 465     TYR B  1316                                                      
REMARK 465     ARG B  1317                                                      
REMARK 465     PRO B  1318                                                      
REMARK 465     ARG B  1319                                                      
REMARK 465     ARG B  1320                                                      
REMARK 465     ASP B  1321                                                      
REMARK 465     ALA B  1322                                                      
REMARK 465     PHE B  1323                                                      
REMARK 465     GLU B  1324                                                      
REMARK 465     ILE B  1325                                                      
REMARK 465     SER B  1326                                                      
REMARK 465     THR B  1327                                                      
REMARK 465     GLU B  1328                                                      
REMARK 465     GLY B  1329                                                      
REMARK 465     HIS B  1330                                                      
REMARK 465     SER B  1331                                                      
REMARK 465     GLY B  1332                                                      
REMARK 465     PRO B  1333                                                      
REMARK 465     SER B  1334                                                      
REMARK 465     ASN B  1335                                                      
REMARK 465     ARG B  1336                                                      
REMARK 465     ALA B  1337                                                      
REMARK 465     ARG B  1338                                                      
REMARK 465     TRP B  1339                                                      
REMARK 465     GLY B  1340                                                      
REMARK 465     PRO B  1341                                                      
REMARK 465     ARG B  1342                                                      
REMARK 465     GLY B  1343                                                      
REMARK 465     ALA B  1344                                                      
REMARK 465     ARG B  1345                                                      
REMARK 465     SER B  1346                                                      
REMARK 465     HIS B  1347                                                      
REMARK 465     ASN B  1348                                                      
REMARK 465     PRO B  1349                                                      
REMARK 465     ARG B  1350                                                      
REMARK 465     ASN B  1351                                                      
REMARK 465     PRO B  1352                                                      
REMARK 465     ALA B  1353                                                      
REMARK 465     SER B  1354                                                      
REMARK 465     THR B  1355                                                      
REMARK 465     ALA B  1356                                                      
REMARK 465     MET B  1357                                                      
REMARK 465     GLY B  1358                                                      
REMARK 465     SER B  1359                                                      
REMARK 465     SER B  1360                                                      
REMARK 465     VAL B  1361                                                      
REMARK 465     PRO B  1362                                                      
REMARK 465     GLY B  1363                                                      
REMARK 465     TYR B  1364                                                      
REMARK 465     CYS B  1365                                                      
REMARK 465     GLN B  1366                                                      
REMARK 465     PRO B  1367                                                      
REMARK 465     ILE B  1368                                                      
REMARK 465     THR B  1369                                                      
REMARK 465     THR B  1370                                                      
REMARK 465     VAL B  1371                                                      
REMARK 465     THR B  1372                                                      
REMARK 465     ALA B  1373                                                      
REMARK 465     SER B  1374                                                      
REMARK 465     ALA B  1375                                                      
REMARK 465     SER B  1376                                                      
REMARK 465     VAL B  1377                                                      
REMARK 465     THR B  1378                                                      
REMARK 465     VAL B  1379                                                      
REMARK 465     ALA B  1380                                                      
REMARK 465     VAL B  1381                                                      
REMARK 465     HIS B  1382                                                      
REMARK 465     PRO B  1383                                                      
REMARK 465     PRO B  1384                                                      
REMARK 465     PRO B  1385                                                      
REMARK 465     VAL B  1386                                                      
REMARK 465     PRO B  1387                                                      
REMARK 465     GLY B  1388                                                      
REMARK 465     PRO B  1389                                                      
REMARK 465     GLY B  1390                                                      
REMARK 465     ARG B  1391                                                      
REMARK 465     ASN B  1392                                                      
REMARK 465     PRO B  1393                                                      
REMARK 465     ARG B  1394                                                      
REMARK 465     GLY B  1395                                                      
REMARK 465     GLY B  1396                                                      
REMARK 465     LEU B  1397                                                      
REMARK 465     CYS B  1398                                                      
REMARK 465     PRO B  1399                                                      
REMARK 465     GLY B  1400                                                      
REMARK 465     TYR B  1401                                                      
REMARK 465     PRO B  1402                                                      
REMARK 465     GLU B  1403                                                      
REMARK 465     THR B  1404                                                      
REMARK 465     ASP B  1405                                                      
REMARK 465     HIS B  1406                                                      
REMARK 465     GLY B  1407                                                      
REMARK 465     LEU B  1408                                                      
REMARK 465     PHE B  1409                                                      
REMARK 465     GLU B  1410                                                      
REMARK 465     ASP B  1411                                                      
REMARK 465     PRO B  1412                                                      
REMARK 465     HIS B  1413                                                      
REMARK 465     VAL B  1414                                                      
REMARK 465     PRO B  1415                                                      
REMARK 465     PHE B  1416                                                      
REMARK 465     HIS B  1417                                                      
REMARK 465     VAL B  1418                                                      
REMARK 465     ARG B  1419                                                      
REMARK 465     CYS B  1420                                                      
REMARK 465     GLU B  1421                                                      
REMARK 465     ARG B  1422                                                      
REMARK 465     ARG B  1423                                                      
REMARK 465     ASP B  1424                                                      
REMARK 465     SER B  1425                                                      
REMARK 465     LYS B  1426                                                      
REMARK 465     VAL B  1427                                                      
REMARK 465     GLU B  1428                                                      
REMARK 465     VAL B  1429                                                      
REMARK 465     ILE B  1430                                                      
REMARK 465     GLU B  1431                                                      
REMARK 465     LEU B  1432                                                      
REMARK 465     GLN B  1433                                                      
REMARK 465     ASP B  1434                                                      
REMARK 465     VAL B  1435                                                      
REMARK 465     GLU B  1436                                                      
REMARK 465     CYS B  1437                                                      
REMARK 465     GLU B  1438                                                      
REMARK 465     GLU B  1439                                                      
REMARK 465     ARG B  1440                                                      
REMARK 465     PRO B  1441                                                      
REMARK 465     ARG B  1442                                                      
REMARK 465     GLY B  1443                                                      
REMARK 465     SER B  1444                                                      
REMARK 465     SER B  1445                                                      
REMARK 465     SER B  1446                                                      
REMARK 465     ASN B  1447                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     THR A 890    OG1  CG2                                            
REMARK 470     SER A 892    OG                                                  
REMARK 470     ARG A 893    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP A 894    CG   OD1  OD2                                       
REMARK 470     LYS A 895    CG   CD   CE   NZ                                   
REMARK 470     PRO A 896    CG   CD                                             
REMARK 470     ILE A 897    CG1  CG2  CD1                                       
REMARK 470     ASP A 898    CG   OD1  OD2                                       
REMARK 470     ILE A 899    CG1  CG2  CD1                                       
REMARK 470     SER A 900    OG                                                  
REMARK 470     GLN A 901    CG   CD   OE1  NE2                                  
REMARK 470     LEU A 902    CG   CD1  CD2                                       
REMARK 470     THR A 903    OG1  CG2                                            
REMARK 470     LYS A 904    CG   CD   CE   NZ                                   
REMARK 470     GLN A 905    CG   CD   OE1  NE2                                  
REMARK 470     ARG A 906    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A 907    CG   CD1  CD2                                       
REMARK 470     VAL A 908    CG1  CG2                                            
REMARK 470     ASP A 909    CG   OD1  OD2                                       
REMARK 470     ASP A 911    CG   OD1  OD2                                       
REMARK 470     ILE A 913    CG1  CG2  CD1                                       
REMARK 470     ILE A 914    CG1  CG2  CD1                                       
REMARK 470     ASN A 915    CG   OD1  ND2                                       
REMARK 470     THR B 890    OG1  CG2                                            
REMARK 470     SER B 892    OG                                                  
REMARK 470     ARG B 893    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B 894    CG   OD1  OD2                                       
REMARK 470     LYS B 895    CG   CD   CE   NZ                                   
REMARK 470     PRO B 896    CG   CD                                             
REMARK 470     ILE B 897    CG1  CG2  CD1                                       
REMARK 470     ASP B 898    CG   OD1  OD2                                       
REMARK 470     ILE B 899    CG1  CG2  CD1                                       
REMARK 470     SER B 900    OG                                                  
REMARK 470     GLN B 901    CG   CD   OE1  NE2                                  
REMARK 470     LEU B 902    CG   CD1  CD2                                       
REMARK 470     THR B 903    OG1  CG2                                            
REMARK 470     LYS B 904    CG   CD   CE   NZ                                   
REMARK 470     GLN B 905    CG   CD   OE1  NE2                                  
REMARK 470     ARG B 906    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU B 907    CG   CD1  CD2                                       
REMARK 470     VAL B 908    CG1  CG2                                            
REMARK 470     ASP B 909    CG   OD1  OD2                                       
REMARK 470     ASP B 911    CG   OD1  OD2                                       
REMARK 470     ILE B 913    CG1  CG2  CD1                                       
REMARK 470     ILE B 914    CG1  CG2  CD1                                       
REMARK 470     ASN B 915    CG   OD1  ND2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO A 896   N   -  CA  -  CB  ANGL. DEV. =   7.5 DEGREES          
REMARK 500    PRO B 896   N   -  CA  -  CB  ANGL. DEV. =   7.2 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    GLU A 122       71.89     58.52                                   
REMARK 500    LEU A 128      -33.62   -130.91                                   
REMARK 500    GLU A 149       -9.69     70.39                                   
REMARK 500    GLU A 165      -70.27    -72.04                                   
REMARK 500    ASN A 168       72.46     59.28                                   
REMARK 500    TYR A 193     -168.49   -111.84                                   
REMARK 500    LYS A 205       76.60     55.75                                   
REMARK 500    SER A 206      -70.92    -40.11                                   
REMARK 500    CYS A 226       73.83     55.92                                   
REMARK 500    LEU A 241       71.75   -101.57                                   
REMARK 500    SER A 243       59.83   -101.46                                   
REMARK 500    LEU A 297       12.42     56.50                                   
REMARK 500    THR A 314     -161.96    -75.71                                   
REMARK 500    PRO A 316      173.38    -59.90                                   
REMARK 500    ARG A 332      -18.97     79.05                                   
REMARK 500    THR A 351     -157.98   -137.65                                   
REMARK 500    SER A 356      118.99   -167.78                                   
REMARK 500    GLN A 365       77.39     55.82                                   
REMARK 500    ASN A 386       71.73     56.35                                   
REMARK 500    GLN A 413       -3.82     71.62                                   
REMARK 500    PHE A 422      119.06   -163.81                                   
REMARK 500    GLN A 466      -64.35    -91.41                                   
REMARK 500    GLU A 534      -10.27     81.97                                   
REMARK 500    LEU A 732     -168.19   -117.08                                   
REMARK 500    TYR A 797      -62.43   -100.28                                   
REMARK 500    PHE A 798       64.25   -101.81                                   
REMARK 500    ASN A 837       14.81     58.60                                   
REMARK 500    THR A 865      -74.67    -83.11                                   
REMARK 500    THR A 890      -54.23   -122.02                                   
REMARK 500    LEU A 902       -1.39     68.49                                   
REMARK 500    ASP A 911      -70.66    -79.37                                   
REMARK 500    PRO A 943       87.98    -68.47                                   
REMARK 500    HIS A 950       76.32     56.25                                   
REMARK 500    MET A 956       74.86     54.60                                   
REMARK 500    THR A 984       -3.19     73.53                                   
REMARK 500    ILE A1108      -66.80    -96.56                                   
REMARK 500    ASP A1110      -66.04    -95.73                                   
REMARK 500    PHE C  30       78.14     55.97                                   
REMARK 500    GLU C  63       47.61     36.53                                   
REMARK 500    LYS C  65       70.23     60.13                                   
REMARK 500    ARG C 144      -62.60    -91.68                                   
REMARK 500    TYR C 174      115.18   -162.73                                   
REMARK 500    ASN B  97       44.84     79.54                                   
REMARK 500    GLU B 150      -58.73    -27.13                                   
REMARK 500    PHE B 153       77.29     42.46                                   
REMARK 500    LEU B 199       77.37    -69.42                                   
REMARK 500    LYS B 205       74.82     55.54                                   
REMARK 500    GLU B 212       50.62    -98.52                                   
REMARK 500    LEU B 223       26.58   -141.54                                   
REMARK 500    CYS B 226       74.19     56.11                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      68 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 TRP A  197     LYS A  198                 -144.31                    
REMARK 500 HIS A  201     LEU A  202                  149.63                    
REMARK 500 TRP B  197     LYS B  198                 -146.84                    
REMARK 500 HIS B  950     ASP B  951                  148.84                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C 203  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU C  90   OE1                                                    
REMARK 620 2 GLU C  90   OE2  47.6                                              
REMARK 620 3 ASP C  95   OD1  98.2 136.7                                        
REMARK 620 4 ASP C 129   OD1  97.8  66.6 100.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C 202  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C  95   OD1                                                    
REMARK 620 2 ASP C  95   OD2  42.9                                              
REMARK 620 3 THR C 125   O    77.5  72.8                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN C 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C 147   OD1                                                    
REMARK 620 2 ASP C 147   OD2  54.8                                              
REMARK 620 3 GLU C 176   OE1 105.1 133.4                                        
REMARK 620 N                    1     2                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN C 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA C 202                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA C 203                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8955   RELATED DB: EMDB                              
REMARK 900 STRUCTURE OF 2:1 HUMAN PTCH1-SHH-N COMPLEX                           
DBREF  6E1H A    1  1447  UNP    Q13635   PTC1_HUMAN       1   1447             
DBREF  6E1H C   24   197  UNP    Q15465   SHH_HUMAN       24    197             
DBREF  6E1H B    1  1447  UNP    Q13635   PTC1_HUMAN       1   1447             
SEQADV 6E1H PLM C   23  UNP  Q15465              INSERTION                      
SEQRES   1 A 1447  MET ALA SER ALA GLY ASN ALA ALA GLU PRO GLN ASP ARG          
SEQRES   2 A 1447  GLY GLY GLY GLY SER GLY CYS ILE GLY ALA PRO GLY ARG          
SEQRES   3 A 1447  PRO ALA GLY GLY GLY ARG ARG ARG ARG THR GLY GLY LEU          
SEQRES   4 A 1447  ARG ARG ALA ALA ALA PRO ASP ARG ASP TYR LEU HIS ARG          
SEQRES   5 A 1447  PRO SER TYR CYS ASP ALA ALA PHE ALA LEU GLU GLN ILE          
SEQRES   6 A 1447  SER LYS GLY LYS ALA THR GLY ARG LYS ALA PRO LEU TRP          
SEQRES   7 A 1447  LEU ARG ALA LYS PHE GLN ARG LEU LEU PHE LYS LEU GLY          
SEQRES   8 A 1447  CYS TYR ILE GLN LYS ASN CYS GLY LYS PHE LEU VAL VAL          
SEQRES   9 A 1447  GLY LEU LEU ILE PHE GLY ALA PHE ALA VAL GLY LEU LYS          
SEQRES  10 A 1447  ALA ALA ASN LEU GLU THR ASN VAL GLU GLU LEU TRP VAL          
SEQRES  11 A 1447  GLU VAL GLY GLY ARG VAL SER ARG GLU LEU ASN TYR THR          
SEQRES  12 A 1447  ARG GLN LYS ILE GLY GLU GLU ALA MET PHE ASN PRO GLN          
SEQRES  13 A 1447  LEU MET ILE GLN THR PRO LYS GLU GLU GLY ALA ASN VAL          
SEQRES  14 A 1447  LEU THR THR GLU ALA LEU LEU GLN HIS LEU ASP SER ALA          
SEQRES  15 A 1447  LEU GLN ALA SER ARG VAL HIS VAL TYR MET TYR ASN ARG          
SEQRES  16 A 1447  GLN TRP LYS LEU GLU HIS LEU CYS TYR LYS SER GLY GLU          
SEQRES  17 A 1447  LEU ILE THR GLU THR GLY TYR MET ASP GLN ILE ILE GLU          
SEQRES  18 A 1447  TYR LEU TYR PRO CYS LEU ILE ILE THR PRO LEU ASP CYS          
SEQRES  19 A 1447  PHE TRP GLU GLY ALA LYS LEU GLN SER GLY THR ALA TYR          
SEQRES  20 A 1447  LEU LEU GLY LYS PRO PRO LEU ARG TRP THR ASN PHE ASP          
SEQRES  21 A 1447  PRO LEU GLU PHE LEU GLU GLU LEU LYS LYS ILE ASN TYR          
SEQRES  22 A 1447  GLN VAL ASP SER TRP GLU GLU MET LEU ASN LYS ALA GLU          
SEQRES  23 A 1447  VAL GLY HIS GLY TYR MET ASP ARG PRO CYS LEU ASN PRO          
SEQRES  24 A 1447  ALA ASP PRO ASP CYS PRO ALA THR ALA PRO ASN LYS ASN          
SEQRES  25 A 1447  SER THR LYS PRO LEU ASP MET ALA LEU VAL LEU ASN GLY          
SEQRES  26 A 1447  GLY CYS HIS GLY LEU SER ARG LYS TYR MET HIS TRP GLN          
SEQRES  27 A 1447  GLU GLU LEU ILE VAL GLY GLY THR VAL LYS ASN SER THR          
SEQRES  28 A 1447  GLY LYS LEU VAL SER ALA HIS ALA LEU GLN THR MET PHE          
SEQRES  29 A 1447  GLN LEU MET THR PRO LYS GLN MET TYR GLU HIS PHE LYS          
SEQRES  30 A 1447  GLY TYR GLU TYR VAL SER HIS ILE ASN TRP ASN GLU ASP          
SEQRES  31 A 1447  LYS ALA ALA ALA ILE LEU GLU ALA TRP GLN ARG THR TYR          
SEQRES  32 A 1447  VAL GLU VAL VAL HIS GLN SER VAL ALA GLN ASN SER THR          
SEQRES  33 A 1447  GLN LYS VAL LEU SER PHE THR THR THR THR LEU ASP ASP          
SEQRES  34 A 1447  ILE LEU LYS SER PHE SER ASP VAL SER VAL ILE ARG VAL          
SEQRES  35 A 1447  ALA SER GLY TYR LEU LEU MET LEU ALA TYR ALA CYS LEU          
SEQRES  36 A 1447  THR MET LEU ARG TRP ASP CYS SER LYS SER GLN GLY ALA          
SEQRES  37 A 1447  VAL GLY LEU ALA GLY VAL LEU LEU VAL ALA LEU SER VAL          
SEQRES  38 A 1447  ALA ALA GLY LEU GLY LEU CYS SER LEU ILE GLY ILE SER          
SEQRES  39 A 1447  PHE ASN ALA ALA THR THR GLN VAL LEU PRO PHE LEU ALA          
SEQRES  40 A 1447  LEU GLY VAL GLY VAL ASP ASP VAL PHE LEU LEU ALA HIS          
SEQRES  41 A 1447  ALA PHE SER GLU THR GLY GLN ASN LYS ARG ILE PRO PHE          
SEQRES  42 A 1447  GLU ASP ARG THR GLY GLU CYS LEU LYS ARG THR GLY ALA          
SEQRES  43 A 1447  SER VAL ALA LEU THR SER ILE SER ASN VAL THR ALA PHE          
SEQRES  44 A 1447  PHE MET ALA ALA LEU ILE PRO ILE PRO ALA LEU ARG ALA          
SEQRES  45 A 1447  PHE SER LEU GLN ALA ALA VAL VAL VAL VAL PHE ASN PHE          
SEQRES  46 A 1447  ALA MET VAL LEU LEU ILE PHE PRO ALA ILE LEU SER MET          
SEQRES  47 A 1447  ASP LEU TYR ARG ARG GLU ASP ARG ARG LEU ASP ILE PHE          
SEQRES  48 A 1447  CYS CYS PHE THR SER PRO CYS VAL SER ARG VAL ILE GLN          
SEQRES  49 A 1447  VAL GLU PRO GLN ALA TYR THR ASP THR HIS ASP ASN THR          
SEQRES  50 A 1447  ARG TYR SER PRO PRO PRO PRO TYR SER SER HIS SER PHE          
SEQRES  51 A 1447  ALA HIS GLU THR GLN ILE THR MET GLN SER THR VAL GLN          
SEQRES  52 A 1447  LEU ARG THR GLU TYR ASP PRO HIS THR HIS VAL TYR TYR          
SEQRES  53 A 1447  THR THR ALA GLU PRO ARG SER GLU ILE SER VAL GLN PRO          
SEQRES  54 A 1447  VAL THR VAL THR GLN ASP THR LEU SER CYS GLN SER PRO          
SEQRES  55 A 1447  GLU SER THR SER SER THR ARG ASP LEU LEU SER GLN PHE          
SEQRES  56 A 1447  SER ASP SER SER LEU HIS CYS LEU GLU PRO PRO CYS THR          
SEQRES  57 A 1447  LYS TRP THR LEU SER SER PHE ALA GLU LYS HIS TYR ALA          
SEQRES  58 A 1447  PRO PHE LEU LEU LYS PRO LYS ALA LYS VAL VAL VAL ILE          
SEQRES  59 A 1447  PHE LEU PHE LEU GLY LEU LEU GLY VAL SER LEU TYR GLY          
SEQRES  60 A 1447  THR THR ARG VAL ARG ASP GLY LEU ASP LEU THR ASP ILE          
SEQRES  61 A 1447  VAL PRO ARG GLU THR ARG GLU TYR ASP PHE ILE ALA ALA          
SEQRES  62 A 1447  GLN PHE LYS TYR PHE SER PHE TYR ASN MET TYR ILE VAL          
SEQRES  63 A 1447  THR GLN LYS ALA ASP TYR PRO ASN ILE GLN HIS LEU LEU          
SEQRES  64 A 1447  TYR ASP LEU HIS ARG SER PHE SER ASN VAL LYS TYR VAL          
SEQRES  65 A 1447  MET LEU GLU GLU ASN LYS GLN LEU PRO LYS MET TRP LEU          
SEQRES  66 A 1447  HIS TYR PHE ARG ASP TRP LEU GLN GLY LEU GLN ASP ALA          
SEQRES  67 A 1447  PHE ASP SER ASP TRP GLU THR GLY LYS ILE MET PRO ASN          
SEQRES  68 A 1447  ASN TYR LYS ASN GLY SER ASP ASP GLY VAL LEU ALA TYR          
SEQRES  69 A 1447  LYS LEU LEU VAL GLN THR GLY SER ARG ASP LYS PRO ILE          
SEQRES  70 A 1447  ASP ILE SER GLN LEU THR LYS GLN ARG LEU VAL ASP ALA          
SEQRES  71 A 1447  ASP GLY ILE ILE ASN PRO SER ALA PHE TYR ILE TYR LEU          
SEQRES  72 A 1447  THR ALA TRP VAL SER ASN ASP PRO VAL ALA TYR ALA ALA          
SEQRES  73 A 1447  SER GLN ALA ASN ILE ARG PRO HIS ARG PRO GLU TRP VAL          
SEQRES  74 A 1447  HIS ASP LYS ALA ASP TYR MET PRO GLU THR ARG LEU ARG          
SEQRES  75 A 1447  ILE PRO ALA ALA GLU PRO ILE GLU TYR ALA GLN PHE PRO          
SEQRES  76 A 1447  PHE TYR LEU ASN GLY LEU ARG ASP THR SER ASP PHE VAL          
SEQRES  77 A 1447  GLU ALA ILE GLU LYS VAL ARG THR ILE CYS SER ASN TYR          
SEQRES  78 A 1447  THR SER LEU GLY LEU SER SER TYR PRO ASN GLY TYR PRO          
SEQRES  79 A 1447  PHE LEU PHE TRP GLU GLN TYR ILE GLY LEU ARG HIS TRP          
SEQRES  80 A 1447  LEU LEU LEU PHE ILE SER VAL VAL LEU ALA CYS THR PHE          
SEQRES  81 A 1447  LEU VAL CYS ALA VAL PHE LEU LEU ASN PRO TRP THR ALA          
SEQRES  82 A 1447  GLY ILE ILE VAL MET VAL LEU ALA LEU MET THR VAL GLU          
SEQRES  83 A 1447  LEU PHE GLY MET MET GLY LEU ILE GLY ILE LYS LEU SER          
SEQRES  84 A 1447  ALA VAL PRO VAL VAL ILE LEU ILE ALA SER VAL GLY ILE          
SEQRES  85 A 1447  GLY VAL GLU PHE THR VAL HIS VAL ALA LEU ALA PHE LEU          
SEQRES  86 A 1447  THR ALA ILE GLY ASP LYS ASN ARG ARG ALA VAL LEU ALA          
SEQRES  87 A 1447  LEU GLU HIS MET PHE ALA PRO VAL LEU ASP GLY ALA VAL          
SEQRES  88 A 1447  SER THR LEU LEU GLY VAL LEU MET LEU ALA GLY SER GLU          
SEQRES  89 A 1447  PHE ASP PHE ILE VAL ARG TYR PHE PHE ALA VAL LEU ALA          
SEQRES  90 A 1447  ILE LEU THR ILE LEU GLY VAL LEU ASN GLY LEU VAL LEU          
SEQRES  91 A 1447  LEU PRO VAL LEU LEU SER PHE PHE GLY PRO TYR PRO GLU          
SEQRES  92 A 1447  VAL SER PRO ALA ASN GLY LEU ASN ARG LEU PRO THR PRO          
SEQRES  93 A 1447  SER PRO GLU PRO PRO PRO SER VAL VAL ARG PHE ALA MET          
SEQRES  94 A 1447  PRO PRO GLY HIS THR HIS SER GLY SER ASP SER SER ASP          
SEQRES  95 A 1447  SER GLU TYR SER SER GLN THR THR VAL SER GLY LEU SER          
SEQRES  96 A 1447  GLU GLU LEU ARG HIS TYR GLU ALA GLN GLN GLY ALA GLY          
SEQRES  97 A 1447  GLY PRO ALA HIS GLN VAL ILE VAL GLU ALA THR GLU ASN          
SEQRES  98 A 1447  PRO VAL PHE ALA HIS SER THR VAL VAL HIS PRO GLU SER          
SEQRES  99 A 1447  ARG HIS HIS PRO PRO SER ASN PRO ARG GLN GLN PRO HIS          
SEQRES 100 A 1447  LEU ASP SER GLY SER LEU PRO PRO GLY ARG GLN GLY GLN          
SEQRES 101 A 1447  GLN PRO ARG ARG ASP PRO PRO ARG GLU GLY LEU TRP PRO          
SEQRES 102 A 1447  PRO PRO TYR ARG PRO ARG ARG ASP ALA PHE GLU ILE SER          
SEQRES 103 A 1447  THR GLU GLY HIS SER GLY PRO SER ASN ARG ALA ARG TRP          
SEQRES 104 A 1447  GLY PRO ARG GLY ALA ARG SER HIS ASN PRO ARG ASN PRO          
SEQRES 105 A 1447  ALA SER THR ALA MET GLY SER SER VAL PRO GLY TYR CYS          
SEQRES 106 A 1447  GLN PRO ILE THR THR VAL THR ALA SER ALA SER VAL THR          
SEQRES 107 A 1447  VAL ALA VAL HIS PRO PRO PRO VAL PRO GLY PRO GLY ARG          
SEQRES 108 A 1447  ASN PRO ARG GLY GLY LEU CYS PRO GLY TYR PRO GLU THR          
SEQRES 109 A 1447  ASP HIS GLY LEU PHE GLU ASP PRO HIS VAL PRO PHE HIS          
SEQRES 110 A 1447  VAL ARG CYS GLU ARG ARG ASP SER LYS VAL GLU VAL ILE          
SEQRES 111 A 1447  GLU LEU GLN ASP VAL GLU CYS GLU GLU ARG PRO ARG GLY          
SEQRES 112 A 1447  SER SER SER ASN                                              
SEQRES   1 C  175  PLM CYS GLY PRO GLY ARG GLY PHE GLY LYS ARG ARG HIS          
SEQRES   2 C  175  PRO LYS LYS LEU THR PRO LEU ALA TYR LYS GLN PHE ILE          
SEQRES   3 C  175  PRO ASN VAL ALA GLU LYS THR LEU GLY ALA SER GLY ARG          
SEQRES   4 C  175  TYR GLU GLY LYS ILE SER ARG ASN SER GLU ARG PHE LYS          
SEQRES   5 C  175  GLU LEU THR PRO ASN TYR ASN PRO ASP ILE ILE PHE LYS          
SEQRES   6 C  175  ASP GLU GLU ASN THR GLY ALA ASP ARG LEU MET THR GLN          
SEQRES   7 C  175  ARG CYS LYS ASP LYS LEU ASN ALA LEU ALA ILE SER VAL          
SEQRES   8 C  175  MET ASN GLN TRP PRO GLY VAL LYS LEU ARG VAL THR GLU          
SEQRES   9 C  175  GLY TRP ASP GLU ASP GLY HIS HIS SER GLU GLU SER LEU          
SEQRES  10 C  175  HIS TYR GLU GLY ARG ALA VAL ASP ILE THR THR SER ASP          
SEQRES  11 C  175  ARG ASP ARG SER LYS TYR GLY MET LEU ALA ARG LEU ALA          
SEQRES  12 C  175  VAL GLU ALA GLY PHE ASP TRP VAL TYR TYR GLU SER LYS          
SEQRES  13 C  175  ALA HIS ILE HIS CYS SER VAL LYS ALA GLU ASN SER VAL          
SEQRES  14 C  175  ALA ALA LYS SER GLY GLY                                      
SEQRES   1 B 1447  MET ALA SER ALA GLY ASN ALA ALA GLU PRO GLN ASP ARG          
SEQRES   2 B 1447  GLY GLY GLY GLY SER GLY CYS ILE GLY ALA PRO GLY ARG          
SEQRES   3 B 1447  PRO ALA GLY GLY GLY ARG ARG ARG ARG THR GLY GLY LEU          
SEQRES   4 B 1447  ARG ARG ALA ALA ALA PRO ASP ARG ASP TYR LEU HIS ARG          
SEQRES   5 B 1447  PRO SER TYR CYS ASP ALA ALA PHE ALA LEU GLU GLN ILE          
SEQRES   6 B 1447  SER LYS GLY LYS ALA THR GLY ARG LYS ALA PRO LEU TRP          
SEQRES   7 B 1447  LEU ARG ALA LYS PHE GLN ARG LEU LEU PHE LYS LEU GLY          
SEQRES   8 B 1447  CYS TYR ILE GLN LYS ASN CYS GLY LYS PHE LEU VAL VAL          
SEQRES   9 B 1447  GLY LEU LEU ILE PHE GLY ALA PHE ALA VAL GLY LEU LYS          
SEQRES  10 B 1447  ALA ALA ASN LEU GLU THR ASN VAL GLU GLU LEU TRP VAL          
SEQRES  11 B 1447  GLU VAL GLY GLY ARG VAL SER ARG GLU LEU ASN TYR THR          
SEQRES  12 B 1447  ARG GLN LYS ILE GLY GLU GLU ALA MET PHE ASN PRO GLN          
SEQRES  13 B 1447  LEU MET ILE GLN THR PRO LYS GLU GLU GLY ALA ASN VAL          
SEQRES  14 B 1447  LEU THR THR GLU ALA LEU LEU GLN HIS LEU ASP SER ALA          
SEQRES  15 B 1447  LEU GLN ALA SER ARG VAL HIS VAL TYR MET TYR ASN ARG          
SEQRES  16 B 1447  GLN TRP LYS LEU GLU HIS LEU CYS TYR LYS SER GLY GLU          
SEQRES  17 B 1447  LEU ILE THR GLU THR GLY TYR MET ASP GLN ILE ILE GLU          
SEQRES  18 B 1447  TYR LEU TYR PRO CYS LEU ILE ILE THR PRO LEU ASP CYS          
SEQRES  19 B 1447  PHE TRP GLU GLY ALA LYS LEU GLN SER GLY THR ALA TYR          
SEQRES  20 B 1447  LEU LEU GLY LYS PRO PRO LEU ARG TRP THR ASN PHE ASP          
SEQRES  21 B 1447  PRO LEU GLU PHE LEU GLU GLU LEU LYS LYS ILE ASN TYR          
SEQRES  22 B 1447  GLN VAL ASP SER TRP GLU GLU MET LEU ASN LYS ALA GLU          
SEQRES  23 B 1447  VAL GLY HIS GLY TYR MET ASP ARG PRO CYS LEU ASN PRO          
SEQRES  24 B 1447  ALA ASP PRO ASP CYS PRO ALA THR ALA PRO ASN LYS ASN          
SEQRES  25 B 1447  SER THR LYS PRO LEU ASP MET ALA LEU VAL LEU ASN GLY          
SEQRES  26 B 1447  GLY CYS HIS GLY LEU SER ARG LYS TYR MET HIS TRP GLN          
SEQRES  27 B 1447  GLU GLU LEU ILE VAL GLY GLY THR VAL LYS ASN SER THR          
SEQRES  28 B 1447  GLY LYS LEU VAL SER ALA HIS ALA LEU GLN THR MET PHE          
SEQRES  29 B 1447  GLN LEU MET THR PRO LYS GLN MET TYR GLU HIS PHE LYS          
SEQRES  30 B 1447  GLY TYR GLU TYR VAL SER HIS ILE ASN TRP ASN GLU ASP          
SEQRES  31 B 1447  LYS ALA ALA ALA ILE LEU GLU ALA TRP GLN ARG THR TYR          
SEQRES  32 B 1447  VAL GLU VAL VAL HIS GLN SER VAL ALA GLN ASN SER THR          
SEQRES  33 B 1447  GLN LYS VAL LEU SER PHE THR THR THR THR LEU ASP ASP          
SEQRES  34 B 1447  ILE LEU LYS SER PHE SER ASP VAL SER VAL ILE ARG VAL          
SEQRES  35 B 1447  ALA SER GLY TYR LEU LEU MET LEU ALA TYR ALA CYS LEU          
SEQRES  36 B 1447  THR MET LEU ARG TRP ASP CYS SER LYS SER GLN GLY ALA          
SEQRES  37 B 1447  VAL GLY LEU ALA GLY VAL LEU LEU VAL ALA LEU SER VAL          
SEQRES  38 B 1447  ALA ALA GLY LEU GLY LEU CYS SER LEU ILE GLY ILE SER          
SEQRES  39 B 1447  PHE ASN ALA ALA THR THR GLN VAL LEU PRO PHE LEU ALA          
SEQRES  40 B 1447  LEU GLY VAL GLY VAL ASP ASP VAL PHE LEU LEU ALA HIS          
SEQRES  41 B 1447  ALA PHE SER GLU THR GLY GLN ASN LYS ARG ILE PRO PHE          
SEQRES  42 B 1447  GLU ASP ARG THR GLY GLU CYS LEU LYS ARG THR GLY ALA          
SEQRES  43 B 1447  SER VAL ALA LEU THR SER ILE SER ASN VAL THR ALA PHE          
SEQRES  44 B 1447  PHE MET ALA ALA LEU ILE PRO ILE PRO ALA LEU ARG ALA          
SEQRES  45 B 1447  PHE SER LEU GLN ALA ALA VAL VAL VAL VAL PHE ASN PHE          
SEQRES  46 B 1447  ALA MET VAL LEU LEU ILE PHE PRO ALA ILE LEU SER MET          
SEQRES  47 B 1447  ASP LEU TYR ARG ARG GLU ASP ARG ARG LEU ASP ILE PHE          
SEQRES  48 B 1447  CYS CYS PHE THR SER PRO CYS VAL SER ARG VAL ILE GLN          
SEQRES  49 B 1447  VAL GLU PRO GLN ALA TYR THR ASP THR HIS ASP ASN THR          
SEQRES  50 B 1447  ARG TYR SER PRO PRO PRO PRO TYR SER SER HIS SER PHE          
SEQRES  51 B 1447  ALA HIS GLU THR GLN ILE THR MET GLN SER THR VAL GLN          
SEQRES  52 B 1447  LEU ARG THR GLU TYR ASP PRO HIS THR HIS VAL TYR TYR          
SEQRES  53 B 1447  THR THR ALA GLU PRO ARG SER GLU ILE SER VAL GLN PRO          
SEQRES  54 B 1447  VAL THR VAL THR GLN ASP THR LEU SER CYS GLN SER PRO          
SEQRES  55 B 1447  GLU SER THR SER SER THR ARG ASP LEU LEU SER GLN PHE          
SEQRES  56 B 1447  SER ASP SER SER LEU HIS CYS LEU GLU PRO PRO CYS THR          
SEQRES  57 B 1447  LYS TRP THR LEU SER SER PHE ALA GLU LYS HIS TYR ALA          
SEQRES  58 B 1447  PRO PHE LEU LEU LYS PRO LYS ALA LYS VAL VAL VAL ILE          
SEQRES  59 B 1447  PHE LEU PHE LEU GLY LEU LEU GLY VAL SER LEU TYR GLY          
SEQRES  60 B 1447  THR THR ARG VAL ARG ASP GLY LEU ASP LEU THR ASP ILE          
SEQRES  61 B 1447  VAL PRO ARG GLU THR ARG GLU TYR ASP PHE ILE ALA ALA          
SEQRES  62 B 1447  GLN PHE LYS TYR PHE SER PHE TYR ASN MET TYR ILE VAL          
SEQRES  63 B 1447  THR GLN LYS ALA ASP TYR PRO ASN ILE GLN HIS LEU LEU          
SEQRES  64 B 1447  TYR ASP LEU HIS ARG SER PHE SER ASN VAL LYS TYR VAL          
SEQRES  65 B 1447  MET LEU GLU GLU ASN LYS GLN LEU PRO LYS MET TRP LEU          
SEQRES  66 B 1447  HIS TYR PHE ARG ASP TRP LEU GLN GLY LEU GLN ASP ALA          
SEQRES  67 B 1447  PHE ASP SER ASP TRP GLU THR GLY LYS ILE MET PRO ASN          
SEQRES  68 B 1447  ASN TYR LYS ASN GLY SER ASP ASP GLY VAL LEU ALA TYR          
SEQRES  69 B 1447  LYS LEU LEU VAL GLN THR GLY SER ARG ASP LYS PRO ILE          
SEQRES  70 B 1447  ASP ILE SER GLN LEU THR LYS GLN ARG LEU VAL ASP ALA          
SEQRES  71 B 1447  ASP GLY ILE ILE ASN PRO SER ALA PHE TYR ILE TYR LEU          
SEQRES  72 B 1447  THR ALA TRP VAL SER ASN ASP PRO VAL ALA TYR ALA ALA          
SEQRES  73 B 1447  SER GLN ALA ASN ILE ARG PRO HIS ARG PRO GLU TRP VAL          
SEQRES  74 B 1447  HIS ASP LYS ALA ASP TYR MET PRO GLU THR ARG LEU ARG          
SEQRES  75 B 1447  ILE PRO ALA ALA GLU PRO ILE GLU TYR ALA GLN PHE PRO          
SEQRES  76 B 1447  PHE TYR LEU ASN GLY LEU ARG ASP THR SER ASP PHE VAL          
SEQRES  77 B 1447  GLU ALA ILE GLU LYS VAL ARG THR ILE CYS SER ASN TYR          
SEQRES  78 B 1447  THR SER LEU GLY LEU SER SER TYR PRO ASN GLY TYR PRO          
SEQRES  79 B 1447  PHE LEU PHE TRP GLU GLN TYR ILE GLY LEU ARG HIS TRP          
SEQRES  80 B 1447  LEU LEU LEU PHE ILE SER VAL VAL LEU ALA CYS THR PHE          
SEQRES  81 B 1447  LEU VAL CYS ALA VAL PHE LEU LEU ASN PRO TRP THR ALA          
SEQRES  82 B 1447  GLY ILE ILE VAL MET VAL LEU ALA LEU MET THR VAL GLU          
SEQRES  83 B 1447  LEU PHE GLY MET MET GLY LEU ILE GLY ILE LYS LEU SER          
SEQRES  84 B 1447  ALA VAL PRO VAL VAL ILE LEU ILE ALA SER VAL GLY ILE          
SEQRES  85 B 1447  GLY VAL GLU PHE THR VAL HIS VAL ALA LEU ALA PHE LEU          
SEQRES  86 B 1447  THR ALA ILE GLY ASP LYS ASN ARG ARG ALA VAL LEU ALA          
SEQRES  87 B 1447  LEU GLU HIS MET PHE ALA PRO VAL LEU ASP GLY ALA VAL          
SEQRES  88 B 1447  SER THR LEU LEU GLY VAL LEU MET LEU ALA GLY SER GLU          
SEQRES  89 B 1447  PHE ASP PHE ILE VAL ARG TYR PHE PHE ALA VAL LEU ALA          
SEQRES  90 B 1447  ILE LEU THR ILE LEU GLY VAL LEU ASN GLY LEU VAL LEU          
SEQRES  91 B 1447  LEU PRO VAL LEU LEU SER PHE PHE GLY PRO TYR PRO GLU          
SEQRES  92 B 1447  VAL SER PRO ALA ASN GLY LEU ASN ARG LEU PRO THR PRO          
SEQRES  93 B 1447  SER PRO GLU PRO PRO PRO SER VAL VAL ARG PHE ALA MET          
SEQRES  94 B 1447  PRO PRO GLY HIS THR HIS SER GLY SER ASP SER SER ASP          
SEQRES  95 B 1447  SER GLU TYR SER SER GLN THR THR VAL SER GLY LEU SER          
SEQRES  96 B 1447  GLU GLU LEU ARG HIS TYR GLU ALA GLN GLN GLY ALA GLY          
SEQRES  97 B 1447  GLY PRO ALA HIS GLN VAL ILE VAL GLU ALA THR GLU ASN          
SEQRES  98 B 1447  PRO VAL PHE ALA HIS SER THR VAL VAL HIS PRO GLU SER          
SEQRES  99 B 1447  ARG HIS HIS PRO PRO SER ASN PRO ARG GLN GLN PRO HIS          
SEQRES 100 B 1447  LEU ASP SER GLY SER LEU PRO PRO GLY ARG GLN GLY GLN          
SEQRES 101 B 1447  GLN PRO ARG ARG ASP PRO PRO ARG GLU GLY LEU TRP PRO          
SEQRES 102 B 1447  PRO PRO TYR ARG PRO ARG ARG ASP ALA PHE GLU ILE SER          
SEQRES 103 B 1447  THR GLU GLY HIS SER GLY PRO SER ASN ARG ALA ARG TRP          
SEQRES 104 B 1447  GLY PRO ARG GLY ALA ARG SER HIS ASN PRO ARG ASN PRO          
SEQRES 105 B 1447  ALA SER THR ALA MET GLY SER SER VAL PRO GLY TYR CYS          
SEQRES 106 B 1447  GLN PRO ILE THR THR VAL THR ALA SER ALA SER VAL THR          
SEQRES 107 B 1447  VAL ALA VAL HIS PRO PRO PRO VAL PRO GLY PRO GLY ARG          
SEQRES 108 B 1447  ASN PRO ARG GLY GLY LEU CYS PRO GLY TYR PRO GLU THR          
SEQRES 109 B 1447  ASP HIS GLY LEU PHE GLU ASP PRO HIS VAL PRO PHE HIS          
SEQRES 110 B 1447  VAL ARG CYS GLU ARG ARG ASP SER LYS VAL GLU VAL ILE          
SEQRES 111 B 1447  GLU LEU GLN ASP VAL GLU CYS GLU GLU ARG PRO ARG GLY          
SEQRES 112 B 1447  SER SER SER ASN                                              
HET    PLM  C  23      17                                                       
HET     ZN  C 201       1                                                       
HET     CA  C 202       1                                                       
HET     CA  C 203       1                                                       
HETNAM     PLM PALMITIC ACID                                                    
HETNAM      ZN ZINC ION                                                         
HETNAM      CA CALCIUM ION                                                      
FORMUL   2  PLM    C16 H32 O2                                                   
FORMUL   4   ZN    ZN 2+                                                        
FORMUL   5   CA    2(CA 2+)                                                     
HELIX    1 AA1 PRO A   76  LYS A   96  1                                  21    
HELIX    2 AA2 ASN A   97  LYS A  100  5                                   4    
HELIX    3 AA3 PHE A  101  LYS A  117  1                                  17    
HELIX    4 AA4 ASN A  124  LEU A  128  5                                   5    
HELIX    5 AA5 GLY A  134  LYS A  146  1                                  13    
HELIX    6 AA6 THR A  171  ARG A  187  1                                  17    
HELIX    7 AA7 TYR A  215  TYR A  224  1                                  10    
HELIX    8 AA8 ASP A  260  ILE A  271  1                                  12    
HELIX    9 AA9 VAL A  275  ASN A  283  1                                   9    
HELIX   10 AB1 THR A  368  PHE A  376  1                                   9    
HELIX   11 AB2 ASN A  388  VAL A  411  1                                  24    
HELIX   12 AB3 THR A  423  ASP A  436  1                                  14    
HELIX   13 AB4 SER A  438  MET A  457  1                                  20    
HELIX   14 AB5 VAL A  469  ILE A  491  1                                  23    
HELIX   15 AB6 ALA A  497  VAL A  502  1                                   6    
HELIX   16 AB7 VAL A  502  THR A  525  1                                  24    
HELIX   17 AB8 ASP A  535  ALA A  563  1                                  29    
HELIX   18 AB9 ILE A  567  ARG A  602  1                                  36    
HELIX   19 AC1 LEU A  732  ALA A  741  1                                  10    
HELIX   20 AC2 PRO A  742  LEU A  745  5                                   4    
HELIX   21 AC3 LYS A  746  ARG A  770  1                                  25    
HELIX   22 AC4 ASP A  776  VAL A  781  1                                   6    
HELIX   23 AC5 THR A  785  TYR A  797  1                                  13    
HELIX   24 AC6 GLN A  816  SER A  825  1                                  10    
HELIX   25 AC7 LEU A  834  LYS A  838  5                                   5    
HELIX   26 AC8 MET A  843  GLY A  866  1                                  24    
HELIX   27 AC9 SER A  877  GLN A  889  1                                  13    
HELIX   28 AD1 ILE A  897  GLN A  901  5                                   5    
HELIX   29 AD2 ALA A  918  ASP A  930  1                                  13    
HELIX   30 AD3 ASP A  930  GLN A  938  1                                   9    
HELIX   31 AD4 SER A  985  GLY A 1005  1                                  21    
HELIX   32 AD5 GLY A 1012  GLU A 1019  1                                   8    
HELIX   33 AD6 GLN A 1020  ILE A 1022  5                                   3    
HELIX   34 AD7 GLY A 1023  LEU A 1048  1                                  26    
HELIX   35 AD8 ASN A 1049  GLY A 1075  1                                  27    
HELIX   36 AD9 SER A 1079  GLY A 1093  1                                  15    
HELIX   37 AE1 GLY A 1093  PHE A 1104  1                                  12    
HELIX   38 AE2 ASN A 1112  MET A 1122  1                                  11    
HELIX   39 AE3 PHE A 1123  LEU A 1138  1                                  16    
HELIX   40 AE4 MET A 1139  ALA A 1141  5                                   3    
HELIX   41 AE5 PHE A 1145  LEU A 1174  1                                  30    
HELIX   42 AE6 SER C   70  LEU C   76  5                                   7    
HELIX   43 AE7 THR C   99  TRP C  117  1                                  19    
HELIX   44 AE8 LYS C  157  GLY C  169  1                                  13    
HELIX   45 AE9 LEU B   77  GLN B   95  1                                  19    
HELIX   46 AF1 LYS B  100  VAL B  114  1                                  15    
HELIX   47 AF2 GLY B  115  ALA B  118  5                                   4    
HELIX   48 AF3 ASN B  124  VAL B  130  1                                   7    
HELIX   49 AF4 ARG B  135  LYS B  146  1                                  12    
HELIX   50 AF5 THR B  171  ARG B  187  1                                  17    
HELIX   51 AF6 THR B  213  TYR B  222  1                                  10    
HELIX   52 AF7 ASP B  260  ILE B  271  1                                  12    
HELIX   53 AF8 VAL B  275  ALA B  285  1                                  11    
HELIX   54 AF9 ASP B  318  LEU B  323  1                                   6    
HELIX   55 AG1 GLN B  338  ILE B  342  1                                   5    
HELIX   56 AG2 THR B  368  PHE B  376  1                                   9    
HELIX   57 AG3 VAL B  382  ASN B  386  5                                   5    
HELIX   58 AG4 ASN B  388  GLN B  409  1                                  22    
HELIX   59 AG5 THR B  424  ASP B  436  1                                  13    
HELIX   60 AG6 SER B  438  MET B  457  1                                  20    
HELIX   61 AG7 GLY B  470  ILE B  491  1                                  22    
HELIX   62 AG8 ASN B  496  ASN B  528  1                                  33    
HELIX   63 AG9 THR B  537  MET B  561  1                                  25    
HELIX   64 AH1 ILE B  567  ARG B  606  1                                  40    
HELIX   65 AH2 LEU B  732  LEU B  744  1                                  13    
HELIX   66 AH3 LYS B  746  ARG B  770  1                                  25    
HELIX   67 AH4 ASP B  776  ILE B  780  5                                   5    
HELIX   68 AH5 THR B  785  TYR B  797  1                                  13    
HELIX   69 AH6 ASP B  811  ASN B  814  5                                   4    
HELIX   70 AH7 ILE B  815  PHE B  826  1                                  12    
HELIX   71 AH8 LEU B  834  LYS B  838  5                                   5    
HELIX   72 AH9 MET B  843  GLU B  864  1                                  22    
HELIX   73 AI1 SER B  877  VAL B  888  1                                  12    
HELIX   74 AI2 ASN B  915  SER B  917  5                                   3    
HELIX   75 AI3 ALA B  918  ASP B  930  1                                  13    
HELIX   76 AI4 ASP B  930  SER B  937  1                                   8    
HELIX   77 AI5 SER B  985  LEU B 1004  1                                  20    
HELIX   78 AI6 TYR B 1013  TRP B 1018  1                                   6    
HELIX   79 AI7 GLY B 1023  LEU B 1047  1                                  25    
HELIX   80 AI8 ASN B 1049  GLY B 1075  1                                  27    
HELIX   81 AI9 SER B 1079  PHE B 1104  1                                  26    
HELIX   82 AJ1 LYS B 1111  HIS B 1121  1                                  11    
HELIX   83 AJ2 MET B 1122  ALA B 1141  1                                  20    
HELIX   84 AJ3 PHE B 1145  VAL B 1169  1                                  25    
HELIX   85 AJ4 LEU B 1170  LEU B 1175  1                                   6    
SHEET    1 AA1 2 PHE A 153  ASN A 154  0                                        
SHEET    2 AA1 2 LEU A 366  MET A 367 -1  O  LEU A 366   N  ASN A 154           
SHEET    1 AA2 4 VAL A 343  GLY A 344  0                                        
SHEET    2 AA2 4 ALA A 359  MET A 363 -1  O  ALA A 359   N  GLY A 344           
SHEET    3 AA2 4 LEU A 157  PRO A 162 -1  N  GLN A 160   O  LEU A 360           
SHEET    4 AA2 4 GLN A 417  PHE A 422 -1  O  LYS A 418   N  THR A 161           
SHEET    1 AA3 3 ALA A 972  ASN A 979  0                                        
SHEET    2 AA3 3 PHE A 800  THR A 807 -1  N  THR A 807   O  ALA A 972           
SHEET    3 AA3 3 SER A1008  ASN A1011 -1  O  TYR A1009   N  VAL A 806           
SHEET    1 AA4 5 ILE C  84  PHE C  86  0                                        
SHEET    2 AA4 5 LEU C 122  VAL C 124  1  O  VAL C 124   N  ILE C  85           
SHEET    3 AA4 5 VAL C 146  THR C 150 -1  O  THR C 149   N  ARG C 123           
SHEET    4 AA4 5 ILE C 181  SER C 184 -1  O  CYS C 183   N  VAL C 146           
SHEET    5 AA4 5 TRP C 172  TYR C 174 -1  N  TYR C 174   O  HIS C 182           
SHEET    1 AA5 4 VAL B 343  GLY B 344  0                                        
SHEET    2 AA5 4 ALA B 359  MET B 363 -1  O  ALA B 359   N  GLY B 344           
SHEET    3 AA5 4 LEU B 157  PRO B 162 -1  N  GLN B 160   O  LEU B 360           
SHEET    4 AA5 4 GLN B 417  PHE B 422 -1  O  LEU B 420   N  ILE B 159           
SHEET    1 AA6 3 ALA B 972  ASN B 979  0                                        
SHEET    2 AA6 3 PHE B 800  THR B 807 -1  N  THR B 807   O  ALA B 972           
SHEET    3 AA6 3 SER B1008  GLY B1012 -1  O  TYR B1009   N  VAL B 806           
SSBOND   1 CYS A  203    CYS A  226                          1555   1555  2.03  
SSBOND   2 CYS A  234    CYS A  327                          1555   1555  2.02  
SSBOND   3 CYS B  203    CYS B  226                          1555   1555  2.03  
SSBOND   4 CYS B  234    CYS B  327                          1555   1555  2.03  
LINK         C1  PLM C  23                 N   CYS C  24     1555   1555  1.32  
LINK         OE1 GLU C  90                CA    CA C 203     1555   1555  2.60  
LINK         OE2 GLU C  90                CA    CA C 203     1555   1555  2.82  
LINK         OD1 ASP C  95                CA    CA C 202     1555   1555  3.17  
LINK         OD1 ASP C  95                CA    CA C 203     1555   1555  2.39  
LINK         OD2 ASP C  95                CA    CA C 202     1555   1555  2.76  
LINK         O   THR C 125                CA    CA C 202     1555   1555  1.96  
LINK         OD1 ASP C 129                CA    CA C 203     1555   1555  2.55  
LINK         OD1 ASP C 147                ZN    ZN C 201     1555   1555  2.34  
LINK         OD2 ASP C 147                ZN    ZN C 201     1555   1555  2.45  
LINK         OE1 GLU C 176                ZN    ZN C 201     1555   1555  2.64  
SITE     1 AC1  6 HIS C 134  HIS C 140  ASP C 147  GLU C 176                    
SITE     2 AC1  6 HIS C 180  HIS C 182                                          
SITE     1 AC2  5 GLU C  89  ASP C  95  THR C 125  GLU C 126                    
SITE     2 AC2  5  CA C 203                                                     
SITE     1 AC3  7 GLU C  89  GLU C  90  ASP C  95  THR C 125                    
SITE     2 AC3  7 GLU C 126  ASP C 129   CA C 202                               
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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