GenomeNet

Database: PDB
Entry: 6E2F
LinkDB: 6E2F
Original site: 6E2F 
HEADER    MEMBRANE PROTEIN                        11-JUL-18   6E2F              
TITLE     CRYO-EM STRUCTURE OF HUMAN TRPV6 IN COMPLEX WITH CALMODULIN           
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V    
COMPND   3 MEMBER 6;                                                            
COMPND   4 CHAIN: A, B, C, D;                                                   
COMPND   5 SYNONYM: TRPV6,CAT-LIKE,CAT-L,CALCIUM TRANSPORT PROTEIN 1,CAT1,      
COMPND   6 EPITHELIAL CALCIUM CHANNEL 2,ECAC2;                                  
COMPND   7 ENGINEERED: YES;                                                     
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: CALMODULIN-1;                                              
COMPND  10 CHAIN: E;                                                            
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: TRPV6, ECAC2;                                                  
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: CALM1, CALM, CAM, CAM1;                                        
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI K-12;                            
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 83333                                       
KEYWDS    TRPV6, TRP CHANNELS, CALCIUM CHANNELS, MEMBRANE PROTEIN               
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    A.K.SINGH,L.L.MCGOLDRICK,A.I.SOBOLEVSKY                               
REVDAT   3   18-DEC-19 6E2F    1       SCALE                                    
REVDAT   2   24-OCT-18 6E2F    1       JRNL                                     
REVDAT   1   22-AUG-18 6E2F    0                                                
JRNL        AUTH   A.K.SINGH,L.L.MCGOLDRICK,E.C.TWOMEY,A.I.SOBOLEVSKY           
JRNL        TITL   MECHANISM OF CALMODULIN INACTIVATION OF THE                  
JRNL        TITL 2 CALCIUM-SELECTIVE TRP CHANNEL TRPV6.                         
JRNL        REF    SCI ADV                       V.   4 U6088 2018              
JRNL        REFN                   ESSN 2375-2548                               
JRNL        PMID   30116787                                                     
JRNL        DOI    10.1126/SCIADV.AAU6088                                       
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION, MOTIONCORR2, CRYOSPARC,           
REMARK   3                            LEGINON, CRYOSPARC                        
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.900                          
REMARK   3   NUMBER OF PARTICLES               : 180600                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6E2F COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 12-JUL-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000235601.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : TRPV6-CALMODULIN                  
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.60                              
REMARK 245   SAMPLE SUPPORT DETAILS         : UNIDENTIFIED                      
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 55.00                          
REMARK 245   ILLUMINATION MODE                 : SPOT SCAN                      
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E                         
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     GLY A     2                                                      
REMARK 465     LEU A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     LEU A     5                                                      
REMARK 465     PRO A     6                                                      
REMARK 465     LYS A     7                                                      
REMARK 465     GLU A     8                                                      
REMARK 465     LYS A     9                                                      
REMARK 465     GLY A    10                                                      
REMARK 465     LEU A    11                                                      
REMARK 465     ILE A    12                                                      
REMARK 465     LEU A    13                                                      
REMARK 465     CYS A    14                                                      
REMARK 465     LEU A    15                                                      
REMARK 465     TRP A    16                                                      
REMARK 465     SER A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     PHE A    19                                                      
REMARK 465     CYS A    20                                                      
REMARK 465     ARG A    21                                                      
REMARK 465     TRP A    22                                                      
REMARK 465     PHE A    23                                                      
REMARK 465     GLN A    24                                                      
REMARK 465     ARG A    25                                                      
REMARK 465     ARG A    26                                                      
REMARK 465     GLU A    27                                                      
REMARK 465     ARG A   641                                                      
REMARK 465     GLN A   642                                                      
REMARK 465     ARG A   643                                                      
REMARK 465     ILE A   644                                                      
REMARK 465     GLN A   645                                                      
REMARK 465     ARG A   646                                                      
REMARK 465     TYR A   647                                                      
REMARK 465     ALA A   648                                                      
REMARK 465     GLN A   649                                                      
REMARK 465     ALA A   650                                                      
REMARK 465     PHE A   651                                                      
REMARK 465     HIS A   652                                                      
REMARK 465     THR A   653                                                      
REMARK 465     ARG A   654                                                      
REMARK 465     GLY A   655                                                      
REMARK 465     SER A   656                                                      
REMARK 465     GLU A   657                                                      
REMARK 465     ASP A   658                                                      
REMARK 465     LEU A   659                                                      
REMARK 465     ASP A   660                                                      
REMARK 465     LYS A   661                                                      
REMARK 465     ASP A   662                                                      
REMARK 465     SER A   663                                                      
REMARK 465     VAL A   664                                                      
REMARK 465     GLU A   665                                                      
REMARK 465     LYS A   666                                                      
REMARK 465     LEU A   667                                                      
REMARK 465     GLU A   668                                                      
REMARK 465     LEU A   669                                                      
REMARK 465     GLY A   670                                                      
REMARK 465     CYS A   671                                                      
REMARK 465     PRO A   672                                                      
REMARK 465     PHE A   673                                                      
REMARK 465     SER A   674                                                      
REMARK 465     PRO A   675                                                      
REMARK 465     HIS A   676                                                      
REMARK 465     LEU A   677                                                      
REMARK 465     SER A   678                                                      
REMARK 465     LEU A   679                                                      
REMARK 465     PRO A   680                                                      
REMARK 465     MET A   681                                                      
REMARK 465     PRO A   682                                                      
REMARK 465     SER A   683                                                      
REMARK 465     VAL A   684                                                      
REMARK 465     SER A   685                                                      
REMARK 465     ARG A   686                                                      
REMARK 465     SER A   687                                                      
REMARK 465     THR A   688                                                      
REMARK 465     SER A   689                                                      
REMARK 465     ARG A   690                                                      
REMARK 465     SER A   691                                                      
REMARK 465     SER A   692                                                      
REMARK 465     ALA A   693                                                      
REMARK 465     ASN A   694                                                      
REMARK 465     TRP A   695                                                      
REMARK 465     GLU A   696                                                      
REMARK 465     ARG A   697                                                      
REMARK 465     LEU A   698                                                      
REMARK 465     ARG A   699                                                      
REMARK 465     GLN A   700                                                      
REMARK 465     GLY A   701                                                      
REMARK 465     THR A   702                                                      
REMARK 465     LEU A   703                                                      
REMARK 465     ARG A   704                                                      
REMARK 465     ARG A   705                                                      
REMARK 465     ASP A   706                                                      
REMARK 465     LEU A   707                                                      
REMARK 465     ARG A   708                                                      
REMARK 465     GLY A   709                                                      
REMARK 465     ILE A   710                                                      
REMARK 465     ILE A   711                                                      
REMARK 465     ASN A   712                                                      
REMARK 465     ARG A   713                                                      
REMARK 465     GLY A   714                                                      
REMARK 465     LEU A   715                                                      
REMARK 465     GLU A   716                                                      
REMARK 465     ASP A   717                                                      
REMARK 465     GLY A   718                                                      
REMARK 465     GLU A   719                                                      
REMARK 465     SER A   720                                                      
REMARK 465     TRP A   721                                                      
REMARK 465     GLU A   722                                                      
REMARK 465     TYR A   723                                                      
REMARK 465     GLN A   724                                                      
REMARK 465     ILE A   725                                                      
REMARK 465     MET B     1                                                      
REMARK 465     GLY B     2                                                      
REMARK 465     LEU B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     LEU B     5                                                      
REMARK 465     PRO B     6                                                      
REMARK 465     LYS B     7                                                      
REMARK 465     GLU B     8                                                      
REMARK 465     LYS B     9                                                      
REMARK 465     GLY B    10                                                      
REMARK 465     LEU B    11                                                      
REMARK 465     ILE B    12                                                      
REMARK 465     LEU B    13                                                      
REMARK 465     CYS B    14                                                      
REMARK 465     LEU B    15                                                      
REMARK 465     TRP B    16                                                      
REMARK 465     SER B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     PHE B    19                                                      
REMARK 465     CYS B    20                                                      
REMARK 465     ARG B    21                                                      
REMARK 465     TRP B    22                                                      
REMARK 465     PHE B    23                                                      
REMARK 465     GLN B    24                                                      
REMARK 465     ARG B    25                                                      
REMARK 465     ARG B    26                                                      
REMARK 465     GLU B    27                                                      
REMARK 465     TYR B   647                                                      
REMARK 465     ALA B   648                                                      
REMARK 465     GLN B   649                                                      
REMARK 465     ALA B   650                                                      
REMARK 465     PHE B   651                                                      
REMARK 465     HIS B   652                                                      
REMARK 465     THR B   653                                                      
REMARK 465     ARG B   654                                                      
REMARK 465     GLY B   655                                                      
REMARK 465     SER B   656                                                      
REMARK 465     GLU B   657                                                      
REMARK 465     ASP B   658                                                      
REMARK 465     LEU B   659                                                      
REMARK 465     ASP B   660                                                      
REMARK 465     LYS B   661                                                      
REMARK 465     ASP B   662                                                      
REMARK 465     SER B   663                                                      
REMARK 465     VAL B   664                                                      
REMARK 465     GLU B   665                                                      
REMARK 465     LYS B   666                                                      
REMARK 465     LEU B   667                                                      
REMARK 465     GLU B   668                                                      
REMARK 465     LEU B   669                                                      
REMARK 465     GLY B   670                                                      
REMARK 465     CYS B   671                                                      
REMARK 465     PRO B   672                                                      
REMARK 465     PHE B   673                                                      
REMARK 465     SER B   674                                                      
REMARK 465     PRO B   675                                                      
REMARK 465     HIS B   676                                                      
REMARK 465     LEU B   677                                                      
REMARK 465     SER B   678                                                      
REMARK 465     LEU B   679                                                      
REMARK 465     PRO B   680                                                      
REMARK 465     MET B   681                                                      
REMARK 465     PRO B   682                                                      
REMARK 465     SER B   683                                                      
REMARK 465     VAL B   684                                                      
REMARK 465     SER B   685                                                      
REMARK 465     ARG B   686                                                      
REMARK 465     SER B   687                                                      
REMARK 465     THR B   688                                                      
REMARK 465     SER B   689                                                      
REMARK 465     ARG B   690                                                      
REMARK 465     SER B   691                                                      
REMARK 465     SER B   692                                                      
REMARK 465     ALA B   693                                                      
REMARK 465     ASN B   694                                                      
REMARK 465     TRP B   695                                                      
REMARK 465     GLU B   696                                                      
REMARK 465     ARG B   697                                                      
REMARK 465     LEU B   698                                                      
REMARK 465     ARG B   699                                                      
REMARK 465     GLN B   700                                                      
REMARK 465     GLY B   701                                                      
REMARK 465     THR B   702                                                      
REMARK 465     LEU B   703                                                      
REMARK 465     ARG B   704                                                      
REMARK 465     ARG B   705                                                      
REMARK 465     ASP B   706                                                      
REMARK 465     LEU B   707                                                      
REMARK 465     ARG B   708                                                      
REMARK 465     GLY B   709                                                      
REMARK 465     ILE B   710                                                      
REMARK 465     ILE B   711                                                      
REMARK 465     ASN B   712                                                      
REMARK 465     ARG B   713                                                      
REMARK 465     GLY B   714                                                      
REMARK 465     LEU B   715                                                      
REMARK 465     GLU B   716                                                      
REMARK 465     ASP B   717                                                      
REMARK 465     GLY B   718                                                      
REMARK 465     GLU B   719                                                      
REMARK 465     SER B   720                                                      
REMARK 465     TRP B   721                                                      
REMARK 465     GLU B   722                                                      
REMARK 465     TYR B   723                                                      
REMARK 465     GLN B   724                                                      
REMARK 465     ILE B   725                                                      
REMARK 465     MET C     1                                                      
REMARK 465     GLY C     2                                                      
REMARK 465     LEU C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     LEU C     5                                                      
REMARK 465     PRO C     6                                                      
REMARK 465     LYS C     7                                                      
REMARK 465     GLU C     8                                                      
REMARK 465     LYS C     9                                                      
REMARK 465     GLY C    10                                                      
REMARK 465     LEU C    11                                                      
REMARK 465     ILE C    12                                                      
REMARK 465     LEU C    13                                                      
REMARK 465     CYS C    14                                                      
REMARK 465     LEU C    15                                                      
REMARK 465     TRP C    16                                                      
REMARK 465     SER C    17                                                      
REMARK 465     LYS C    18                                                      
REMARK 465     PHE C    19                                                      
REMARK 465     CYS C    20                                                      
REMARK 465     ARG C    21                                                      
REMARK 465     TRP C    22                                                      
REMARK 465     PHE C    23                                                      
REMARK 465     GLN C    24                                                      
REMARK 465     ARG C    25                                                      
REMARK 465     ARG C    26                                                      
REMARK 465     GLU C    27                                                      
REMARK 465     GLY C   655                                                      
REMARK 465     SER C   656                                                      
REMARK 465     GLU C   657                                                      
REMARK 465     ASP C   658                                                      
REMARK 465     LEU C   659                                                      
REMARK 465     ASP C   660                                                      
REMARK 465     LYS C   661                                                      
REMARK 465     ASP C   662                                                      
REMARK 465     SER C   663                                                      
REMARK 465     VAL C   664                                                      
REMARK 465     GLU C   665                                                      
REMARK 465     LYS C   666                                                      
REMARK 465     LEU C   667                                                      
REMARK 465     GLU C   668                                                      
REMARK 465     LEU C   669                                                      
REMARK 465     GLY C   670                                                      
REMARK 465     CYS C   671                                                      
REMARK 465     PRO C   672                                                      
REMARK 465     PHE C   673                                                      
REMARK 465     SER C   674                                                      
REMARK 465     PRO C   675                                                      
REMARK 465     HIS C   676                                                      
REMARK 465     LEU C   677                                                      
REMARK 465     SER C   678                                                      
REMARK 465     LEU C   679                                                      
REMARK 465     PRO C   680                                                      
REMARK 465     MET C   681                                                      
REMARK 465     PRO C   682                                                      
REMARK 465     SER C   683                                                      
REMARK 465     VAL C   684                                                      
REMARK 465     SER C   685                                                      
REMARK 465     ASP C   706                                                      
REMARK 465     LEU C   707                                                      
REMARK 465     ARG C   708                                                      
REMARK 465     GLY C   709                                                      
REMARK 465     ILE C   710                                                      
REMARK 465     ILE C   711                                                      
REMARK 465     ASN C   712                                                      
REMARK 465     ARG C   713                                                      
REMARK 465     GLY C   714                                                      
REMARK 465     LEU C   715                                                      
REMARK 465     GLU C   716                                                      
REMARK 465     ASP C   717                                                      
REMARK 465     GLY C   718                                                      
REMARK 465     GLU C   719                                                      
REMARK 465     SER C   720                                                      
REMARK 465     TRP C   721                                                      
REMARK 465     GLU C   722                                                      
REMARK 465     TYR C   723                                                      
REMARK 465     GLN C   724                                                      
REMARK 465     ILE C   725                                                      
REMARK 465     MET D     1                                                      
REMARK 465     GLY D     2                                                      
REMARK 465     LEU D     3                                                      
REMARK 465     SER D     4                                                      
REMARK 465     LEU D     5                                                      
REMARK 465     PRO D     6                                                      
REMARK 465     LYS D     7                                                      
REMARK 465     GLU D     8                                                      
REMARK 465     LYS D     9                                                      
REMARK 465     GLY D    10                                                      
REMARK 465     LEU D    11                                                      
REMARK 465     ILE D    12                                                      
REMARK 465     LEU D    13                                                      
REMARK 465     CYS D    14                                                      
REMARK 465     LEU D    15                                                      
REMARK 465     TRP D    16                                                      
REMARK 465     SER D    17                                                      
REMARK 465     LYS D    18                                                      
REMARK 465     PHE D    19                                                      
REMARK 465     CYS D    20                                                      
REMARK 465     ARG D    21                                                      
REMARK 465     TRP D    22                                                      
REMARK 465     PHE D    23                                                      
REMARK 465     GLN D    24                                                      
REMARK 465     ARG D    25                                                      
REMARK 465     ARG D    26                                                      
REMARK 465     GLU D    27                                                      
REMARK 465     ARG D   641                                                      
REMARK 465     GLN D   642                                                      
REMARK 465     ARG D   643                                                      
REMARK 465     ILE D   644                                                      
REMARK 465     GLN D   645                                                      
REMARK 465     ARG D   646                                                      
REMARK 465     TYR D   647                                                      
REMARK 465     ALA D   648                                                      
REMARK 465     GLN D   649                                                      
REMARK 465     ALA D   650                                                      
REMARK 465     PHE D   651                                                      
REMARK 465     HIS D   652                                                      
REMARK 465     THR D   653                                                      
REMARK 465     ARG D   654                                                      
REMARK 465     GLY D   655                                                      
REMARK 465     SER D   656                                                      
REMARK 465     GLU D   657                                                      
REMARK 465     ASP D   658                                                      
REMARK 465     LEU D   659                                                      
REMARK 465     ASP D   660                                                      
REMARK 465     LYS D   661                                                      
REMARK 465     ASP D   662                                                      
REMARK 465     SER D   663                                                      
REMARK 465     VAL D   664                                                      
REMARK 465     GLU D   665                                                      
REMARK 465     LYS D   666                                                      
REMARK 465     LEU D   667                                                      
REMARK 465     GLU D   668                                                      
REMARK 465     LEU D   669                                                      
REMARK 465     GLY D   670                                                      
REMARK 465     CYS D   671                                                      
REMARK 465     PRO D   672                                                      
REMARK 465     PHE D   673                                                      
REMARK 465     SER D   674                                                      
REMARK 465     PRO D   675                                                      
REMARK 465     HIS D   676                                                      
REMARK 465     LEU D   677                                                      
REMARK 465     SER D   678                                                      
REMARK 465     LEU D   679                                                      
REMARK 465     PRO D   680                                                      
REMARK 465     MET D   681                                                      
REMARK 465     PRO D   682                                                      
REMARK 465     SER D   683                                                      
REMARK 465     VAL D   684                                                      
REMARK 465     SER D   685                                                      
REMARK 465     ARG D   686                                                      
REMARK 465     SER D   687                                                      
REMARK 465     THR D   688                                                      
REMARK 465     SER D   689                                                      
REMARK 465     ARG D   690                                                      
REMARK 465     SER D   691                                                      
REMARK 465     SER D   692                                                      
REMARK 465     ALA D   693                                                      
REMARK 465     ASN D   694                                                      
REMARK 465     TRP D   695                                                      
REMARK 465     GLU D   696                                                      
REMARK 465     ARG D   697                                                      
REMARK 465     LEU D   698                                                      
REMARK 465     ARG D   699                                                      
REMARK 465     GLN D   700                                                      
REMARK 465     GLY D   701                                                      
REMARK 465     THR D   702                                                      
REMARK 465     LEU D   703                                                      
REMARK 465     ARG D   704                                                      
REMARK 465     ARG D   705                                                      
REMARK 465     ASP D   706                                                      
REMARK 465     LEU D   707                                                      
REMARK 465     ARG D   708                                                      
REMARK 465     GLY D   709                                                      
REMARK 465     ILE D   710                                                      
REMARK 465     ILE D   711                                                      
REMARK 465     ASN D   712                                                      
REMARK 465     ARG D   713                                                      
REMARK 465     GLY D   714                                                      
REMARK 465     LEU D   715                                                      
REMARK 465     GLU D   716                                                      
REMARK 465     ASP D   717                                                      
REMARK 465     GLY D   718                                                      
REMARK 465     GLU D   719                                                      
REMARK 465     SER D   720                                                      
REMARK 465     TRP D   721                                                      
REMARK 465     GLU D   722                                                      
REMARK 465     TYR D   723                                                      
REMARK 465     GLN D   724                                                      
REMARK 465     ILE D   725                                                      
REMARK 465     MET E     0                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A 372   CA  -  CB  -  CG  ANGL. DEV. =  18.8 DEGREES          
REMARK 500    LEU B 372   CA  -  CB  -  CG  ANGL. DEV. =  16.5 DEGREES          
REMARK 500    LEU C 372   CA  -  CB  -  CG  ANGL. DEV. =  19.4 DEGREES          
REMARK 500    LEU D 372   CA  -  CB  -  CG  ANGL. DEV. =  17.4 DEGREES          
REMARK 500    LEU D 639   CA  -  CB  -  CG  ANGL. DEV. =  19.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A  56       55.57    -93.02                                   
REMARK 500    GLN A  74       97.31    -69.75                                   
REMARK 500    TYR A  89       49.30    -94.50                                   
REMARK 500    ASP A  90       43.82     34.05                                   
REMARK 500    GLU A 113      -10.85     70.24                                   
REMARK 500    GLN A 128      -18.21     74.67                                   
REMARK 500    ASP A 223       42.89    -97.73                                   
REMARK 500    LEU A 232      -11.97     71.10                                   
REMARK 500    LEU A 280       61.84     62.73                                   
REMARK 500    SER A 285       34.17    -93.07                                   
REMARK 500    GLN A 290      -23.14     75.29                                   
REMARK 500    SER A 291      -30.67     65.21                                   
REMARK 500    LEU A 292      -47.71   -146.47                                   
REMARK 500    TYR A 324       -7.36     72.44                                   
REMARK 500    LEU A 372       85.02     52.72                                   
REMARK 500    LEU A 373      140.79    -37.18                                   
REMARK 500    MET A 410       48.57    -93.02                                   
REMARK 500    PRO A 424       41.18    -84.28                                   
REMARK 500    PHE A 425      -72.85   -109.25                                   
REMARK 500    HIS A 426        1.36     38.04                                   
REMARK 500    SER A 448      -66.05    -92.50                                   
REMARK 500    PHE A 472      -28.60     70.31                                   
REMARK 500    GLN A 473     -177.37    169.97                                   
REMARK 500    ILE A 540      -55.04   -120.09                                   
REMARK 500    ASN A 546      -37.26   -130.93                                   
REMARK 500    TYR A 547       -0.33     65.37                                   
REMARK 500    ARG A 589      -37.06   -134.10                                   
REMARK 500    TRP A 613       79.93     45.42                                   
REMARK 500    ARG A 621       -1.17     58.23                                   
REMARK 500    ASN B  56       52.07    -95.72                                   
REMARK 500    HIS B  73       33.75    -93.61                                   
REMARK 500    TYR B  89       50.27    -92.71                                   
REMARK 500    ASP B  90       44.29     34.20                                   
REMARK 500    GLU B 113      -12.31     72.08                                   
REMARK 500    LEU B 114      -39.27   -130.27                                   
REMARK 500    GLN B 128      -16.12     75.56                                   
REMARK 500    MET B 130       -2.69   -140.38                                   
REMARK 500    ARG B 139       34.16    -94.72                                   
REMARK 500    LEU B 232      -13.68     70.22                                   
REMARK 500    SER B 285       33.08    -92.55                                   
REMARK 500    GLN B 290      -21.68     75.03                                   
REMARK 500    SER B 291      -29.81     65.27                                   
REMARK 500    LEU B 292      -49.16   -146.30                                   
REMARK 500    TYR B 324       -8.22     71.91                                   
REMARK 500    THR B 366       31.86   -140.91                                   
REMARK 500    LYS B 371       61.72     60.20                                   
REMARK 500    LEU B 372       82.30     46.80                                   
REMARK 500    GLN B 374      -66.92    -91.33                                   
REMARK 500    GLU B 375       49.14   -140.53                                   
REMARK 500    MET B 410       51.12    -91.57                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     135 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 GLN A  290     SER A  291                  134.74                    
REMARK 500 LYS A  371     LEU A  372                  141.20                    
REMARK 500 PHE A  425     HIS A  426                  143.40                    
REMARK 500 GLN B  290     SER B  291                  140.61                    
REMARK 500 LYS B  371     LEU B  372                  134.17                    
REMARK 500 PHE B  425     HIS B  426                  142.21                    
REMARK 500 ASN C  129     MET C  130                  149.12                    
REMARK 500 GLN C  290     SER C  291                  140.38                    
REMARK 500 LYS C  371     LEU C  372                  135.91                    
REMARK 500 PHE C  425     HIS C  426                  147.98                    
REMARK 500 GLN D  290     SER D  291                  142.20                    
REMARK 500 LYS D  371     LEU D  372                  134.55                    
REMARK 500 PHE D  425     HIS D  426                  145.72                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA A 901  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 542   OD1                                                    
REMARK 620 2 ASP B 542   OD1  64.2                                              
REMARK 620 3 ASP D 542   OD1  63.3  92.0                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E 401  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP E  20   OD1                                                    
REMARK 620 2 THR E  26   O    73.2                                              
REMARK 620 3 GLU E  31   OE1  79.7  71.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E 402  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP E  56   OD1                                                    
REMARK 620 2 ASP E  58   OD1  65.3                                              
REMARK 620 3 ASN E  60   OD1  73.1  70.0                                        
REMARK 620 4 THR E  62   O    67.0 123.4  68.4                                  
REMARK 620 5 GLU E  67   OE1  68.3 110.9 135.6  76.7                            
REMARK 620 6 GLU E  67   OE2  67.1  65.7 129.4 119.1  50.1                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E 403  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP E  93   OD1                                                    
REMARK 620 2 ASP E  95   OD1  58.3                                              
REMARK 620 3 ASN E  97   OD1  66.2  73.8                                        
REMARK 620 4 TYR E  99   O    99.8 142.6  69.3                                  
REMARK 620 5 GLU E 104   OE1  74.0 105.7 133.0  94.9                            
REMARK 620 6 GLU E 104   OE2  76.7  64.8 134.8 145.0  50.3                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E 404  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP E 129   OD1                                                    
REMARK 620 2 ASP E 131   OD1  68.2                                              
REMARK 620 3 ASP E 133   OD1  72.8  81.2                                        
REMARK 620 4 GLN E 135   O    75.2 135.2  63.5                                  
REMARK 620 5 ASN E 137   OD1 135.1 102.3 151.5 122.0                            
REMARK 620 6 GLU E 140   OE1  66.6 112.7 126.3  73.2  78.9                      
REMARK 620 7 GLU E 140   OE2  68.7  71.5 138.8 118.0  66.8  46.9                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 901                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA A 902                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA E 401                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA E 402                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA E 403                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA E 404                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8961   RELATED DB: EMDB                              
REMARK 900 CRYO-EM STRUCTURE OF HUMAN TRPV6 IN COMPLEX WITH CALMODULIN          
DBREF  6E2F A    1   725  UNP    Q9H1D0   TRPV6_HUMAN     41    765             
DBREF  6E2F B    1   725  UNP    Q9H1D0   TRPV6_HUMAN     41    765             
DBREF  6E2F C    1   725  UNP    Q9H1D0   TRPV6_HUMAN     41    765             
DBREF  6E2F D    1   725  UNP    Q9H1D0   TRPV6_HUMAN     41    765             
DBREF  6E2F E    0   148  UNP    P0DP23   CALM1_HUMAN      1    149             
SEQRES   1 A  725  MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU          
SEQRES   2 A  725  CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG          
SEQRES   3 A  725  GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU          
SEQRES   4 A  725  GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA          
SEQRES   5 A  725  ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU          
SEQRES   6 A  725  LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET          
SEQRES   7 A  725  GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN          
SEQRES   8 A  725  LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU          
SEQRES   9 A  725  LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY          
SEQRES  10 A  725  GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET          
SEQRES  11 A  725  ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL          
SEQRES  12 A  725  SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO          
SEQRES  13 A  725  CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE          
SEQRES  14 A  725  ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU          
SEQRES  15 A  725  ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU          
SEQRES  16 A  725  GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN          
SEQRES  17 A  725  LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER          
SEQRES  18 A  725  TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU          
SEQRES  19 A  725  VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA          
SEQRES  20 A  725  GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET          
SEQRES  21 A  725  GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU          
SEQRES  22 A  725  THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER          
SEQRES  23 A  725  GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR          
SEQRES  24 A  725  LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO          
SEQRES  25 A  725  VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY          
SEQRES  26 A  725  ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU          
SEQRES  27 A  725  TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO          
SEQRES  28 A  725  LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP          
SEQRES  29 A  725  ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR          
SEQRES  30 A  725  MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU          
SEQRES  31 A  725  VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU          
SEQRES  32 A  725  VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE          
SEQRES  33 A  725  GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE          
SEQRES  34 A  725  ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET          
SEQRES  35 A  725  ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER          
SEQRES  36 A  725  PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET TYR PHE          
SEQRES  37 A  725  ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET          
SEQRES  38 A  725  ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS          
SEQRES  39 A  725  TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA          
SEQRES  40 A  725  PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU          
SEQRES  41 A  725  GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR          
SEQRES  42 A  725  PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN          
SEQRES  43 A  725  TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR          
SEQRES  44 A  725  ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN          
SEQRES  45 A  725  LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL          
SEQRES  46 A  725  ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL          
SEQRES  47 A  725  ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS          
SEQRES  48 A  725  LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY          
SEQRES  49 A  725  LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN          
SEQRES  50 A  725  ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA          
SEQRES  51 A  725  PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER          
SEQRES  52 A  725  VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS          
SEQRES  53 A  725  LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER          
SEQRES  54 A  725  ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR          
SEQRES  55 A  725  LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU          
SEQRES  56 A  725  GLU ASP GLY GLU SER TRP GLU TYR GLN ILE                      
SEQRES   1 B  725  MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU          
SEQRES   2 B  725  CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG          
SEQRES   3 B  725  GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU          
SEQRES   4 B  725  GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA          
SEQRES   5 B  725  ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU          
SEQRES   6 B  725  LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET          
SEQRES   7 B  725  GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN          
SEQRES   8 B  725  LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU          
SEQRES   9 B  725  LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY          
SEQRES  10 B  725  GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET          
SEQRES  11 B  725  ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL          
SEQRES  12 B  725  SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO          
SEQRES  13 B  725  CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE          
SEQRES  14 B  725  ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU          
SEQRES  15 B  725  ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU          
SEQRES  16 B  725  GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN          
SEQRES  17 B  725  LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER          
SEQRES  18 B  725  TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU          
SEQRES  19 B  725  VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA          
SEQRES  20 B  725  GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET          
SEQRES  21 B  725  GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU          
SEQRES  22 B  725  THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER          
SEQRES  23 B  725  GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR          
SEQRES  24 B  725  LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO          
SEQRES  25 B  725  VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY          
SEQRES  26 B  725  ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU          
SEQRES  27 B  725  TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO          
SEQRES  28 B  725  LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP          
SEQRES  29 B  725  ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR          
SEQRES  30 B  725  MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU          
SEQRES  31 B  725  VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU          
SEQRES  32 B  725  VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE          
SEQRES  33 B  725  GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE          
SEQRES  34 B  725  ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET          
SEQRES  35 B  725  ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER          
SEQRES  36 B  725  PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET TYR PHE          
SEQRES  37 B  725  ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET          
SEQRES  38 B  725  ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS          
SEQRES  39 B  725  TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA          
SEQRES  40 B  725  PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU          
SEQRES  41 B  725  GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR          
SEQRES  42 B  725  PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN          
SEQRES  43 B  725  TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR          
SEQRES  44 B  725  ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN          
SEQRES  45 B  725  LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL          
SEQRES  46 B  725  ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL          
SEQRES  47 B  725  ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS          
SEQRES  48 B  725  LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY          
SEQRES  49 B  725  LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN          
SEQRES  50 B  725  ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA          
SEQRES  51 B  725  PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER          
SEQRES  52 B  725  VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS          
SEQRES  53 B  725  LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER          
SEQRES  54 B  725  ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR          
SEQRES  55 B  725  LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU          
SEQRES  56 B  725  GLU ASP GLY GLU SER TRP GLU TYR GLN ILE                      
SEQRES   1 C  725  MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU          
SEQRES   2 C  725  CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG          
SEQRES   3 C  725  GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU          
SEQRES   4 C  725  GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA          
SEQRES   5 C  725  ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU          
SEQRES   6 C  725  LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET          
SEQRES   7 C  725  GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN          
SEQRES   8 C  725  LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU          
SEQRES   9 C  725  LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY          
SEQRES  10 C  725  GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET          
SEQRES  11 C  725  ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL          
SEQRES  12 C  725  SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO          
SEQRES  13 C  725  CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE          
SEQRES  14 C  725  ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU          
SEQRES  15 C  725  ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU          
SEQRES  16 C  725  GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN          
SEQRES  17 C  725  LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER          
SEQRES  18 C  725  TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU          
SEQRES  19 C  725  VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA          
SEQRES  20 C  725  GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET          
SEQRES  21 C  725  GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU          
SEQRES  22 C  725  THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER          
SEQRES  23 C  725  GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR          
SEQRES  24 C  725  LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO          
SEQRES  25 C  725  VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY          
SEQRES  26 C  725  ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU          
SEQRES  27 C  725  TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO          
SEQRES  28 C  725  LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP          
SEQRES  29 C  725  ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR          
SEQRES  30 C  725  MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU          
SEQRES  31 C  725  VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU          
SEQRES  32 C  725  VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE          
SEQRES  33 C  725  GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE          
SEQRES  34 C  725  ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET          
SEQRES  35 C  725  ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER          
SEQRES  36 C  725  PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET TYR PHE          
SEQRES  37 C  725  ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET          
SEQRES  38 C  725  ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS          
SEQRES  39 C  725  TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA          
SEQRES  40 C  725  PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU          
SEQRES  41 C  725  GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR          
SEQRES  42 C  725  PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN          
SEQRES  43 C  725  TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR          
SEQRES  44 C  725  ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN          
SEQRES  45 C  725  LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL          
SEQRES  46 C  725  ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL          
SEQRES  47 C  725  ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS          
SEQRES  48 C  725  LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY          
SEQRES  49 C  725  LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN          
SEQRES  50 C  725  ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA          
SEQRES  51 C  725  PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER          
SEQRES  52 C  725  VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS          
SEQRES  53 C  725  LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER          
SEQRES  54 C  725  ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR          
SEQRES  55 C  725  LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU          
SEQRES  56 C  725  GLU ASP GLY GLU SER TRP GLU TYR GLN ILE                      
SEQRES   1 D  725  MET GLY LEU SER LEU PRO LYS GLU LYS GLY LEU ILE LEU          
SEQRES   2 D  725  CYS LEU TRP SER LYS PHE CYS ARG TRP PHE GLN ARG ARG          
SEQRES   3 D  725  GLU SER TRP ALA GLN SER ARG ASP GLU GLN ASN LEU LEU          
SEQRES   4 D  725  GLN GLN LYS ARG ILE TRP GLU SER PRO LEU LEU LEU ALA          
SEQRES   5 D  725  ALA LYS ASP ASN ASP VAL GLN ALA LEU ASN LYS LEU LEU          
SEQRES   6 D  725  LYS TYR GLU ASP CYS LYS VAL HIS GLN ARG GLY ALA MET          
SEQRES   7 D  725  GLY GLU THR ALA LEU HIS ILE ALA ALA LEU TYR ASP ASN          
SEQRES   8 D  725  LEU GLU ALA ALA MET VAL LEU MET GLU ALA ALA PRO GLU          
SEQRES   9 D  725  LEU VAL PHE GLU PRO MET THR SER GLU LEU TYR GLU GLY          
SEQRES  10 D  725  GLN THR ALA LEU HIS ILE ALA VAL VAL ASN GLN ASN MET          
SEQRES  11 D  725  ASN LEU VAL ARG ALA LEU LEU ALA ARG ARG ALA SER VAL          
SEQRES  12 D  725  SER ALA ARG ALA THR GLY THR ALA PHE ARG ARG SER PRO          
SEQRES  13 D  725  CYS ASN LEU ILE TYR PHE GLY GLU HIS PRO LEU SER PHE          
SEQRES  14 D  725  ALA ALA CYS VAL ASN SER GLU GLU ILE VAL ARG LEU LEU          
SEQRES  15 D  725  ILE GLU HIS GLY ALA ASP ILE ARG ALA GLN ASP SER LEU          
SEQRES  16 D  725  GLY ASN THR VAL LEU HIS ILE LEU ILE LEU GLN PRO ASN          
SEQRES  17 D  725  LYS THR PHE ALA CYS GLN MET TYR ASN LEU LEU LEU SER          
SEQRES  18 D  725  TYR ASP ARG HIS GLY ASP HIS LEU GLN PRO LEU ASP LEU          
SEQRES  19 D  725  VAL PRO ASN HIS GLN GLY LEU THR PRO PHE LYS LEU ALA          
SEQRES  20 D  725  GLY VAL GLU GLY ASN THR VAL MET PHE GLN HIS LEU MET          
SEQRES  21 D  725  GLN LYS ARG LYS HIS THR GLN TRP THR TYR GLY PRO LEU          
SEQRES  22 D  725  THR SER THR LEU TYR ASP LEU THR GLU ILE ASP SER SER          
SEQRES  23 D  725  GLY ASP GLU GLN SER LEU LEU GLU LEU ILE ILE THR THR          
SEQRES  24 D  725  LYS LYS ARG GLU ALA ARG GLN ILE LEU ASP GLN THR PRO          
SEQRES  25 D  725  VAL LYS GLU LEU VAL SER LEU LYS TRP LYS ARG TYR GLY          
SEQRES  26 D  725  ARG PRO TYR PHE CYS MET LEU GLY ALA ILE TYR LEU LEU          
SEQRES  27 D  725  TYR ILE ILE CYS PHE THR MET CYS CYS ILE TYR ARG PRO          
SEQRES  28 D  725  LEU LYS PRO ARG THR ASN ASN ARG THR SER PRO ARG ASP          
SEQRES  29 D  725  ASN THR LEU LEU GLN GLN LYS LEU LEU GLN GLU ALA TYR          
SEQRES  30 D  725  MET THR PRO LYS ASP ASP ILE ARG LEU VAL GLY GLU LEU          
SEQRES  31 D  725  VAL THR VAL ILE GLY ALA ILE ILE ILE LEU LEU VAL GLU          
SEQRES  32 D  725  VAL PRO ASP ILE PHE ARG MET GLY VAL THR ARG PHE PHE          
SEQRES  33 D  725  GLY GLN THR ILE LEU GLY GLY PRO PHE HIS VAL LEU ILE          
SEQRES  34 D  725  ILE THR TYR ALA PHE MET VAL LEU VAL THR MET VAL MET          
SEQRES  35 D  725  ARG LEU ILE SER ALA SER GLY GLU VAL VAL PRO MET SER          
SEQRES  36 D  725  PHE ALA LEU VAL LEU GLY TRP CYS ASN VAL MET TYR PHE          
SEQRES  37 D  725  ALA ARG GLY PHE GLN MET LEU GLY PRO PHE THR ILE MET          
SEQRES  38 D  725  ILE GLN LYS MET ILE PHE GLY ASP LEU MET ARG PHE CYS          
SEQRES  39 D  725  TRP LEU MET ALA VAL VAL ILE LEU GLY PHE ALA SER ALA          
SEQRES  40 D  725  PHE TYR ILE ILE PHE GLN THR GLU ASP PRO GLU GLU LEU          
SEQRES  41 D  725  GLY HIS PHE TYR ASP TYR PRO MET ALA LEU PHE SER THR          
SEQRES  42 D  725  PHE GLU LEU PHE LEU THR ILE ILE ASP GLY PRO ALA ASN          
SEQRES  43 D  725  TYR ASN VAL ASP LEU PRO PHE MET TYR SER ILE THR TYR          
SEQRES  44 D  725  ALA ALA PHE ALA ILE ILE ALA THR LEU LEU MET LEU ASN          
SEQRES  45 D  725  LEU LEU ILE ALA MET MET GLY ASP THR HIS TRP ARG VAL          
SEQRES  46 D  725  ALA HIS GLU ARG ASP GLU LEU TRP ARG ALA GLN ILE VAL          
SEQRES  47 D  725  ALA THR THR VAL MET LEU GLU ARG LYS LEU PRO ARG CYS          
SEQRES  48 D  725  LEU TRP PRO ARG SER GLY ILE CYS GLY ARG GLU TYR GLY          
SEQRES  49 D  725  LEU GLY ASP ARG TRP PHE LEU ARG VAL GLU ASP ARG GLN          
SEQRES  50 D  725  ASP LEU ASN ARG GLN ARG ILE GLN ARG TYR ALA GLN ALA          
SEQRES  51 D  725  PHE HIS THR ARG GLY SER GLU ASP LEU ASP LYS ASP SER          
SEQRES  52 D  725  VAL GLU LYS LEU GLU LEU GLY CYS PRO PHE SER PRO HIS          
SEQRES  53 D  725  LEU SER LEU PRO MET PRO SER VAL SER ARG SER THR SER          
SEQRES  54 D  725  ARG SER SER ALA ASN TRP GLU ARG LEU ARG GLN GLY THR          
SEQRES  55 D  725  LEU ARG ARG ASP LEU ARG GLY ILE ILE ASN ARG GLY LEU          
SEQRES  56 D  725  GLU ASP GLY GLU SER TRP GLU TYR GLN ILE                      
SEQRES   1 E  149  MET ALA ASP GLN LEU THR GLU GLU GLN ILE ALA GLU PHE          
SEQRES   2 E  149  LYS GLU ALA PHE SER LEU PHE ASP LYS ASP GLY ASP GLY          
SEQRES   3 E  149  THR ILE THR THR LYS GLU LEU GLY THR VAL MET ARG SER          
SEQRES   4 E  149  LEU GLY GLN ASN PRO THR GLU ALA GLU LEU GLN ASP MET          
SEQRES   5 E  149  ILE ASN GLU VAL ASP ALA ASP GLY ASN GLY THR ILE ASP          
SEQRES   6 E  149  PHE PRO GLU PHE LEU THR MET MET ALA ARG LYS MET LYS          
SEQRES   7 E  149  ASP THR ASP SER GLU GLU GLU ILE ARG GLU ALA PHE ARG          
SEQRES   8 E  149  VAL PHE ASP LYS ASP GLY ASN GLY TYR ILE SER ALA ALA          
SEQRES   9 E  149  GLU LEU ARG HIS VAL MET THR ASN LEU GLY GLU LYS LEU          
SEQRES  10 E  149  THR ASP GLU GLU VAL ASP GLU MET ILE ARG GLU ALA ASP          
SEQRES  11 E  149  ILE ASP GLY ASP GLY GLN VAL ASN TYR GLU GLU PHE VAL          
SEQRES  12 E  149  GLN MET MET THR ALA LYS                                      
HET     CA  A 901       1                                                       
HET     CA  A 902       1                                                       
HET     CA  E 401       1                                                       
HET     CA  E 402       1                                                       
HET     CA  E 403       1                                                       
HET     CA  E 404       1                                                       
HETNAM      CA CALCIUM ION                                                      
FORMUL   6   CA    6(CA 2+)                                                     
HELIX    1 AA1 SER A   28  SER A   47  1                                  20    
HELIX    2 AA2 SER A   47  ASP A   55  1                                   9    
HELIX    3 AA3 ASP A   57  GLU A   68  1                                  12    
HELIX    4 AA4 THR A   81  TYR A   89  1                                   9    
HELIX    5 AA5 ASN A   91  ALA A  102  1                                  12    
HELIX    6 AA6 THR A  119  ASN A  127  1                                   9    
HELIX    7 AA7 ASN A  131  ARG A  139  1                                   9    
HELIX    8 AA8 GLY A  149  ARG A  153  5                                   5    
HELIX    9 AA9 HIS A  165  VAL A  173  1                                   9    
HELIX   10 AB1 SER A  175  GLU A  184  1                                  10    
HELIX   11 AB2 THR A  198  LEU A  205  1                                   8    
HELIX   12 AB3 LYS A  209  PHE A  211  5                                   3    
HELIX   13 AB4 ALA A  212  TYR A  222  1                                  11    
HELIX   14 AB5 THR A  242  GLY A  251  1                                  10    
HELIX   15 AB6 ASN A  252  GLN A  261  1                                  10    
HELIX   16 AB7 LEU A  292  THR A  298  1                                   7    
HELIX   17 AB8 ARG A  302  ASP A  309  5                                   8    
HELIX   18 AB9 GLN A  310  ARG A  323  1                                  14    
HELIX   19 AC1 GLY A  325  TYR A  349  1                                  25    
HELIX   20 AC2 PRO A  380  PHE A  408  1                                  29    
HELIX   21 AC3 VAL A  412  GLY A  423  1                                  12    
HELIX   22 AC4 VAL A  427  SER A  446  1                                  20    
HELIX   23 AC5 GLU A  450  ASN A  464  1                                  15    
HELIX   24 AC6 VAL A  465  ARG A  470  5                                   6    
HELIX   25 AC7 PRO A  477  PHE A  487  1                                  11    
HELIX   26 AC8 LEU A  490  PHE A  512  1                                  23    
HELIX   27 AC9 LEU A  520  TYR A  524  5                                   5    
HELIX   28 AD1 ASP A  525  PHE A  537  1                                  13    
HELIX   29 AD2 MET A  554  THR A  567  1                                  14    
HELIX   30 AD3 LEU A  569  THR A  581  1                                  13    
HELIX   31 AD4 ARG A  589  LYS A  607  1                                  19    
HELIX   32 AD5 ALA B   30  SER B   47  1                                  18    
HELIX   33 AD6 SER B   47  ASP B   55  1                                   9    
HELIX   34 AD7 ASP B   57  GLU B   68  1                                  12    
HELIX   35 AD8 THR B   81  TYR B   89  1                                   9    
HELIX   36 AD9 ASN B   91  ALA B  102  1                                  12    
HELIX   37 AE1 GLU B  104  GLU B  108  5                                   5    
HELIX   38 AE2 THR B  119  ASN B  127  1                                   9    
HELIX   39 AE3 ASN B  131  ARG B  139  1                                   9    
HELIX   40 AE4 GLY B  149  ARG B  153  5                                   5    
HELIX   41 AE5 HIS B  165  VAL B  173  1                                   9    
HELIX   42 AE6 SER B  175  GLU B  184  1                                  10    
HELIX   43 AE7 THR B  198  LEU B  205  1                                   8    
HELIX   44 AE8 LYS B  209  SER B  221  1                                  13    
HELIX   45 AE9 THR B  242  GLY B  251  1                                  10    
HELIX   46 AF1 ASN B  252  GLN B  261  1                                  10    
HELIX   47 AF2 LEU B  292  THR B  298  1                                   7    
HELIX   48 AF3 ARG B  302  ASP B  309  5                                   8    
HELIX   49 AF4 GLN B  310  ARG B  323  1                                  14    
HELIX   50 AF5 GLY B  325  TYR B  349  1                                  25    
HELIX   51 AF6 THR B  379  VAL B  404  1                                  26    
HELIX   52 AF7 VAL B  412  ILE B  420  1                                   9    
HELIX   53 AF8 VAL B  427  SER B  446  1                                  20    
HELIX   54 AF9 GLU B  450  ASN B  464  1                                  15    
HELIX   55 AG1 VAL B  465  GLY B  471  5                                   7    
HELIX   56 AG2 PRO B  477  PHE B  487  1                                  11    
HELIX   57 AG3 LEU B  490  PHE B  512  1                                  23    
HELIX   58 AG4 LEU B  520  TYR B  524  5                                   5    
HELIX   59 AG5 ASP B  525  LEU B  538  1                                  14    
HELIX   60 AG6 MET B  554  THR B  567  1                                  14    
HELIX   61 AG7 LEU B  569  HIS B  582  1                                  14    
HELIX   62 AG8 ALA B  586  LYS B  607  1                                  22    
HELIX   63 AG9 LEU B  639  GLN B  645  1                                   7    
HELIX   64 AH1 TRP C   29  SER C   47  1                                  19    
HELIX   65 AH2 SER C   47  ASP C   55  1                                   9    
HELIX   66 AH3 ASP C   57  GLU C   68  1                                  12    
HELIX   67 AH4 THR C   81  TYR C   89  1                                   9    
HELIX   68 AH5 ASN C   91  ALA C  102  1                                  12    
HELIX   69 AH6 GLU C  104  GLU C  108  5                                   5    
HELIX   70 AH7 THR C  119  ASN C  127  1                                   9    
HELIX   71 AH8 LEU C  132  ARG C  139  1                                   8    
HELIX   72 AH9 HIS C  165  VAL C  173  1                                   9    
HELIX   73 AI1 SER C  175  GLU C  184  1                                  10    
HELIX   74 AI2 THR C  198  LEU C  205  1                                   8    
HELIX   75 AI3 LYS C  209  PHE C  211  5                                   3    
HELIX   76 AI4 ALA C  212  SER C  221  1                                  10    
HELIX   77 AI5 THR C  242  GLY C  251  1                                  10    
HELIX   78 AI6 ASN C  252  GLN C  261  1                                  10    
HELIX   79 AI7 LEU C  292  THR C  298  1                                   7    
HELIX   80 AI8 ARG C  302  ASP C  309  5                                   8    
HELIX   81 AI9 GLN C  310  ARG C  323  1                                  14    
HELIX   82 AJ1 GLY C  325  TYR C  349  1                                  25    
HELIX   83 AJ2 PRO C  380  GLU C  403  1                                  24    
HELIX   84 AJ3 GLU C  403  MET C  410  1                                   8    
HELIX   85 AJ4 VAL C  412  GLY C  423  1                                  12    
HELIX   86 AJ5 VAL C  427  SER C  446  1                                  20    
HELIX   87 AJ6 GLU C  450  ASN C  464  1                                  15    
HELIX   88 AJ7 VAL C  465  ARG C  470  5                                   6    
HELIX   89 AJ8 PRO C  477  PHE C  487  1                                  11    
HELIX   90 AJ9 GLY C  488  PHE C  512  1                                  25    
HELIX   91 AK1 ASP C  525  LEU C  538  1                                  14    
HELIX   92 AK2 MET C  554  THR C  567  1                                  14    
HELIX   93 AK3 LEU C  569  ARG C  584  1                                  16    
HELIX   94 AK4 ALA C  586  LYS C  607  1                                  22    
HELIX   95 AK5 ASN C  640  HIS C  652  1                                  13    
HELIX   96 AK6 SER C  687  LEU C  703  1                                  17    
HELIX   97 AK7 ALA D   30  SER D   47  1                                  18    
HELIX   98 AK8 SER D   47  ASP D   55  1                                   9    
HELIX   99 AK9 ASP D   57  LYS D   66  1                                  10    
HELIX  100 AL1 THR D   81  TYR D   89  1                                   9    
HELIX  101 AL2 ASN D   91  ALA D  102  1                                  12    
HELIX  102 AL3 THR D  119  ASN D  127  1                                   9    
HELIX  103 AL4 LEU D  132  ARG D  139  1                                   8    
HELIX  104 AL5 GLY D  149  ARG D  153  5                                   5    
HELIX  105 AL6 HIS D  165  VAL D  173  1                                   9    
HELIX  106 AL7 SER D  175  GLU D  184  1                                  10    
HELIX  107 AL8 THR D  198  LEU D  205  1                                   8    
HELIX  108 AL9 LYS D  209  PHE D  211  5                                   3    
HELIX  109 AM1 ALA D  212  TYR D  222  1                                  11    
HELIX  110 AM2 THR D  242  GLY D  251  1                                  10    
HELIX  111 AM3 ASN D  252  GLN D  261  1                                  10    
HELIX  112 AM4 LEU D  292  THR D  298  1                                   7    
HELIX  113 AM5 ARG D  302  GLN D  310  5                                   9    
HELIX  114 AM6 VAL D  313  ARG D  323  1                                  11    
HELIX  115 AM7 GLY D  325  CYS D  346  1                                  22    
HELIX  116 AM8 THR D  379  PHE D  408  1                                  30    
HELIX  117 AM9 VAL D  412  GLY D  423  1                                  12    
HELIX  118 AN1 VAL D  427  ILE D  445  1                                  19    
HELIX  119 AN2 GLU D  450  VAL D  465  1                                  16    
HELIX  120 AN3 MET D  466  GLY D  471  5                                   6    
HELIX  121 AN4 PRO D  477  PHE D  487  1                                  11    
HELIX  122 AN5 GLY D  488  PHE D  512  1                                  25    
HELIX  123 AN6 LEU D  520  TYR D  524  5                                   5    
HELIX  124 AN7 ASP D  525  LEU D  538  1                                  14    
HELIX  125 AN8 PRO D  552  THR D  567  1                                  16    
HELIX  126 AN9 LEU D  569  ARG D  584  1                                  16    
HELIX  127 AO1 ALA D  586  LYS D  607  1                                  22    
HELIX  128 AO2 THR E    5  ASP E   20  1                                  16    
HELIX  129 AO3 THR E   28  LEU E   39  1                                  12    
HELIX  130 AO4 ALA E   46  ASP E   56  1                                  11    
HELIX  131 AO5 ASP E   64  LYS E   75  1                                  12    
HELIX  132 AO6 GLU E   83  ASP E   93  1                                  11    
HELIX  133 AO7 SER E  101  GLY E  113  1                                  13    
HELIX  134 AO8 THR E  117  ASP E  129  1                                  13    
HELIX  135 AO9 ASN E  137  THR E  146  1                                  10    
SHEET    1 AA1 3 THR A 269  TYR A 270  0                                        
SHEET    2 AA1 3 LEU A 273  TYR A 278 -1  O  LEU A 273   N  TYR A 270           
SHEET    3 AA1 3 LEU A 631  ARG A 636 -1  O  VAL A 633   N  THR A 276           
SHEET    1 AA2 3 THR B 269  TYR B 270  0                                        
SHEET    2 AA2 3 LEU B 273  TYR B 278 -1  O  LEU B 273   N  TYR B 270           
SHEET    3 AA2 3 LEU B 631  ARG B 636 -1  O  VAL B 633   N  THR B 276           
SHEET    1 AA3 3 THR C 269  TYR C 270  0                                        
SHEET    2 AA3 3 LEU C 273  TYR C 278 -1  O  LEU C 273   N  TYR C 270           
SHEET    3 AA3 3 LEU C 631  ARG C 636 -1  O  ASP C 635   N  THR C 274           
SHEET    1 AA4 3 THR D 269  TYR D 270  0                                        
SHEET    2 AA4 3 LEU D 273  TYR D 278 -1  O  LEU D 273   N  TYR D 270           
SHEET    3 AA4 3 LEU D 631  ARG D 636 -1  O  LEU D 631   N  TYR D 278           
LINK         OD1 ASP A 542                CA    CA A 901     1555   1555  2.83  
LINK         OD1 ASP B 542                CA    CA A 901     1555   1555  2.52  
LINK         OD1 ASP D 542                CA    CA A 901     1555   1555  2.59  
LINK         OD1 ASP E  20                CA    CA E 401     1555   1555  2.52  
LINK         O   THR E  26                CA    CA E 401     1555   1555  2.55  
LINK         OE1 GLU E  31                CA    CA E 401     1555   1555  2.50  
LINK         OD1 ASP E  56                CA    CA E 402     1555   1555  2.65  
LINK         OD1 ASP E  58                CA    CA E 402     1555   1555  2.58  
LINK         OD1 ASN E  60                CA    CA E 402     1555   1555  2.49  
LINK         O   THR E  62                CA    CA E 402     1555   1555  2.64  
LINK         OE1 GLU E  67                CA    CA E 402     1555   1555  2.50  
LINK         OE2 GLU E  67                CA    CA E 402     1555   1555  2.67  
LINK         OD1 ASP E  93                CA    CA E 403     1555   1555  2.88  
LINK         OD1 ASP E  95                CA    CA E 403     1555   1555  2.97  
LINK         OD1 ASN E  97                CA    CA E 403     1555   1555  2.52  
LINK         O   TYR E  99                CA    CA E 403     1555   1555  2.54  
LINK         OE1 GLU E 104                CA    CA E 403     1555   1555  2.63  
LINK         OE2 GLU E 104                CA    CA E 403     1555   1555  2.51  
LINK         OD1 ASP E 129                CA    CA E 404     1555   1555  2.55  
LINK         OD1 ASP E 131                CA    CA E 404     1555   1555  2.52  
LINK         OD1 ASP E 133                CA    CA E 404     1555   1555  2.79  
LINK         O   GLN E 135                CA    CA E 404     1555   1555  2.67  
LINK         OD1 ASN E 137                CA    CA E 404     1555   1555  3.00  
LINK         OE1 GLU E 140                CA    CA E 404     1555   1555  2.88  
LINK         OE2 GLU E 140                CA    CA E 404     1555   1555  2.58  
SITE     1 AC1  4 ASP A 542   CA A 902  ASP B 542  ASP D 542                    
SITE     1 AC2  1  CA A 901                                                     
SITE     1 AC3  4 ASP E  20  THR E  26  ILE E  27  GLU E  31                    
SITE     1 AC4  6 ASP E  56  ASP E  58  ASN E  60  THR E  62                    
SITE     2 AC4  6 ASP E  64  GLU E  67                                          
SITE     1 AC5  5 ASP E  93  ASP E  95  ASN E  97  TYR E  99                    
SITE     2 AC5  5 GLU E 104                                                     
SITE     1 AC6  6 ASP E 129  ASP E 131  ASP E 133  GLN E 135                    
SITE     2 AC6  6 ASN E 137  GLU E 140                                          
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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