GenomeNet

Database: PDB
Entry: 6E3Y
LinkDB: 6E3Y
Original site: 6E3Y 
HEADER    SIGNALING PROTEIN                       16-JUL-18   6E3Y              
TITLE     CRYO-EM STRUCTURE OF THE ACTIVE, GS-PROTEIN COMPLEXED, HUMAN CGRP     
TITLE    2 RECEPTOR                                                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: CALCITONIN GENE-RELATED PEPTIDE 1;                         
COMPND   3 CHAIN: P;                                                            
COMPND   4 FRAGMENT: RESIDUES 83-119;                                           
COMPND   5 SYNONYM: ALPHA-TYPE CGRP,CALCITONIN GENE-RELATED PEPTIDE I,CGRP-I;   
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: NANOBODY 35;                                               
COMPND   9 CHAIN: N;                                                            
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) SUBUNIT ALPHA      
COMPND  13 ISOFORMS SHORT;                                                      
COMPND  14 CHAIN: A;                                                            
COMPND  15 SYNONYM: ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN;              
COMPND  16 ENGINEERED: YES;                                                     
COMPND  17 MUTATION: YES;                                                       
COMPND  18 MOL_ID: 4;                                                           
COMPND  19 MOLECULE: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) SUBUNIT  
COMPND  20 BETA-1;                                                              
COMPND  21 CHAIN: B;                                                            
COMPND  22 SYNONYM: TRANSDUCIN BETA CHAIN 1;                                    
COMPND  23 ENGINEERED: YES;                                                     
COMPND  24 MOL_ID: 5;                                                           
COMPND  25 MOLECULE: GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(O) SUBUNIT  
COMPND  26 GAMMA-2;                                                             
COMPND  27 CHAIN: G;                                                            
COMPND  28 SYNONYM: G GAMMA-I;                                                  
COMPND  29 ENGINEERED: YES;                                                     
COMPND  30 MOL_ID: 6;                                                           
COMPND  31 MOLECULE: CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR;           
COMPND  32 CHAIN: R;                                                            
COMPND  33 SYNONYM: CGRP TYPE 1 RECEPTOR,CALCITONIN RECEPTOR-LIKE RECEPTOR;     
COMPND  34 ENGINEERED: YES;                                                     
COMPND  35 MOL_ID: 7;                                                           
COMPND  36 MOLECULE: RECEPTOR ACTIVITY-MODIFYING PROTEIN 1;                     
COMPND  37 CHAIN: E;                                                            
COMPND  38 SYNONYM: CALCITONIN-RECEPTOR-LIKE RECEPTOR ACTIVITY-MODIFYING PROTEIN
COMPND  39 1,CRLR ACTIVITY-MODIFYING PROTEIN 1;                                 
COMPND  40 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 SYNTHETIC: YES;                                                      
SOURCE   3 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   4 ORGANISM_COMMON: HUMAN;                                              
SOURCE   5 ORGANISM_TAXID: 9606;                                                
SOURCE   6 MOL_ID: 2;                                                           
SOURCE   7 ORGANISM_SCIENTIFIC: LAMA GLAMA;                                     
SOURCE   8 ORGANISM_COMMON: LLAMA;                                              
SOURCE   9 ORGANISM_TAXID: 9844;                                                
SOURCE  10 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  11 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  12 MOL_ID: 3;                                                           
SOURCE  13 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  14 ORGANISM_COMMON: HUMAN;                                              
SOURCE  15 ORGANISM_TAXID: 9606;                                                
SOURCE  16 GENE: GNAS, GNAS1, GSP;                                              
SOURCE  17 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  18 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  19 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  20 MOL_ID: 4;                                                           
SOURCE  21 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  22 ORGANISM_COMMON: HUMAN;                                              
SOURCE  23 ORGANISM_TAXID: 9606;                                                
SOURCE  24 GENE: GNB1;                                                          
SOURCE  25 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  26 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  27 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  28 MOL_ID: 5;                                                           
SOURCE  29 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  30 ORGANISM_COMMON: HUMAN;                                              
SOURCE  31 ORGANISM_TAXID: 9606;                                                
SOURCE  32 GENE: GNG2;                                                          
SOURCE  33 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  34 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  35 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  36 MOL_ID: 6;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  38 ORGANISM_COMMON: HUMAN;                                              
SOURCE  39 ORGANISM_TAXID: 9606;                                                
SOURCE  40 GENE: CALCRL, CGRPR;                                                 
SOURCE  41 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  42 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  43 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  44 MOL_ID: 7;                                                           
SOURCE  45 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  46 ORGANISM_COMMON: HUMAN;                                              
SOURCE  47 ORGANISM_TAXID: 9606;                                                
SOURCE  48 GENE: RAMP1;                                                         
SOURCE  49 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  50 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  51 EXPRESSION_SYSTEM_TAXID: 7111                                        
KEYWDS    CLASS B G PROTEIN-COUPLED RECEPTOR, AGONIST-RECEPTOR-G PROTEIN        
KEYWDS   2 TERNARY COMPLEX, CALCITONIN GENE-RELATED PEPTIDE RECEPTOR, RECEPTOR  
KEYWDS   3 ACTIVITY MODIFYING PROTEIN 1, ACTIVE-STATE G PROTEIN-COUPLED         
KEYWDS   4 RECEPTOR, SIGNALING PROTEIN, PHASE PLATE, PHASE CONTRAST             
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    Y.L.LIANG,M.KHOSHOUEI,G.DEGANUTTI,A.GLUKHOVA,C.KOOLE,T.S.PEAT,        
AUTHOR   2 M.RADJAINIA,J.M.PLITZKO,W.BAUMEISTER,L.J.MILLER,D.L.HAY,             
AUTHOR   3 A.CHRISTOPOULOS,C.A.REYNOLDS,D.WOOTTEN,P.M.SEXTON                    
REVDAT   4   15-JAN-20 6E3Y    1       COMPND                                   
REVDAT   3   10-OCT-18 6E3Y    1       COMPND JRNL                              
REVDAT   2   26-SEP-18 6E3Y    1       JRNL                                     
REVDAT   1   19-SEP-18 6E3Y    0                                                
JRNL        AUTH   Y.L.LIANG,M.KHOSHOUEI,G.DEGANUTTI,A.GLUKHOVA,C.KOOLE,        
JRNL        AUTH 2 T.S.PEAT,M.RADJAINIA,J.M.PLITZKO,W.BAUMEISTER,L.J.MILLER,    
JRNL        AUTH 3 D.L.HAY,A.CHRISTOPOULOS,C.A.REYNOLDS,D.WOOTTEN,P.M.SEXTON    
JRNL        TITL   CRYO-EM STRUCTURE OF THE ACTIVE, GS-PROTEIN COMPLEXED, HUMAN 
JRNL        TITL 2 CGRP RECEPTOR.                                               
JRNL        REF    NATURE                        V. 561   492 2018              
JRNL        REFN                   ESSN 1476-4687                               
JRNL        PMID   30209400                                                     
JRNL        DOI    10.1038/S41586-018-0535-Y                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.30 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : COOT, PHENIX                              
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.300                          
REMARK   3   NUMBER OF PARTICLES               : 407000                         
REMARK   3   CTF CORRECTION METHOD             : NONE                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6E3Y COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 16-JUL-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000234808.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : COMPLEX OF A FULL-LENGTH,         
REMARK 245                                    ACTIVE-STATE CALCITONIN GENE-     
REMARK 245                                    RELATED PEPTIDE RECEPTOR WITH     
REMARK 245                                    CALCITONIN GENE-RELATED PEPTIDE   
REMARK 245                                    LIGAND, HETEROTRIMERIC GS         
REMARK 245                                    PROTEIN AND NANOBODY35            
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.40                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 50.00                          
REMARK 245   ILLUMINATION MODE                 : OTHER                          
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : 47170                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEPTAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: P, N, A, B, G, R, E                   
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     LYS P    24                                                      
REMARK 465     ASN P    25                                                      
REMARK 465     ASN P    26                                                      
REMARK 465     SER N   127                                                      
REMARK 465     SER N   128                                                      
REMARK 465     HIS N   129                                                      
REMARK 465     HIS N   130                                                      
REMARK 465     HIS N   131                                                      
REMARK 465     HIS N   132                                                      
REMARK 465     HIS N   133                                                      
REMARK 465     HIS N   134                                                      
REMARK 465     GLU N   135                                                      
REMARK 465     PRO N   136                                                      
REMARK 465     GLU N   137                                                      
REMARK 465     ALA N   138                                                      
REMARK 465     MET A     1                                                      
REMARK 465     GLY A     2                                                      
REMARK 465     CYS A     3                                                      
REMARK 465     LEU A     4                                                      
REMARK 465     GLY A     5                                                      
REMARK 465     ASN A     6                                                      
REMARK 465     SER A     7                                                      
REMARK 465     LYS A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     GLU A    10                                                      
REMARK 465     ASP A    11                                                      
REMARK 465     GLN A    12                                                      
REMARK 465     ARG A    13                                                      
REMARK 465     ASN A    14                                                      
REMARK 465     ALA A    48                                                      
REMARK 465     GLY A    49                                                      
REMARK 465     GLU A    50                                                      
REMARK 465     SER A    51                                                      
REMARK 465     GLY A    52                                                      
REMARK 465     LYS A    53                                                      
REMARK 465     ASN A    54                                                      
REMARK 465     THR A    55                                                      
REMARK 465     ILE A    56                                                      
REMARK 465     VAL A    57                                                      
REMARK 465     LYS A    58                                                      
REMARK 465     GLN A    59                                                      
REMARK 465     MET A    60                                                      
REMARK 465     ARG A    61                                                      
REMARK 465     ILE A    62                                                      
REMARK 465     LEU A    63                                                      
REMARK 465     HIS A    64                                                      
REMARK 465     VAL A    65                                                      
REMARK 465     ASN A    66                                                      
REMARK 465     GLY A    67                                                      
REMARK 465     PHE A    68                                                      
REMARK 465     ASN A    69                                                      
REMARK 465     GLY A    70                                                      
REMARK 465     GLU A    71                                                      
REMARK 465     GLY A    72                                                      
REMARK 465     GLY A    73                                                      
REMARK 465     GLU A    74                                                      
REMARK 465     GLU A    75                                                      
REMARK 465     ASP A    76                                                      
REMARK 465     PRO A    77                                                      
REMARK 465     GLN A    78                                                      
REMARK 465     ALA A    79                                                      
REMARK 465     ALA A    80                                                      
REMARK 465     ARG A    81                                                      
REMARK 465     SER A    82                                                      
REMARK 465     ASN A    83                                                      
REMARK 465     SER A    84                                                      
REMARK 465     ASP A    85                                                      
REMARK 465     GLY A    86                                                      
REMARK 465     GLU A    87                                                      
REMARK 465     LYS A    88                                                      
REMARK 465     ALA A    89                                                      
REMARK 465     THR A    90                                                      
REMARK 465     LYS A    91                                                      
REMARK 465     VAL A    92                                                      
REMARK 465     GLN A    93                                                      
REMARK 465     ASP A    94                                                      
REMARK 465     ILE A    95                                                      
REMARK 465     LYS A    96                                                      
REMARK 465     ASN A    97                                                      
REMARK 465     ASN A    98                                                      
REMARK 465     LEU A    99                                                      
REMARK 465     LYS A   100                                                      
REMARK 465     GLU A   101                                                      
REMARK 465     ALA A   102                                                      
REMARK 465     ILE A   103                                                      
REMARK 465     GLU A   104                                                      
REMARK 465     THR A   105                                                      
REMARK 465     ILE A   106                                                      
REMARK 465     VAL A   107                                                      
REMARK 465     ALA A   108                                                      
REMARK 465     ALA A   109                                                      
REMARK 465     MET A   110                                                      
REMARK 465     SER A   111                                                      
REMARK 465     ASN A   112                                                      
REMARK 465     LEU A   113                                                      
REMARK 465     VAL A   114                                                      
REMARK 465     PRO A   115                                                      
REMARK 465     PRO A   116                                                      
REMARK 465     VAL A   117                                                      
REMARK 465     GLU A   118                                                      
REMARK 465     LEU A   119                                                      
REMARK 465     ALA A   120                                                      
REMARK 465     ASN A   121                                                      
REMARK 465     PRO A   122                                                      
REMARK 465     GLU A   123                                                      
REMARK 465     ASN A   124                                                      
REMARK 465     GLN A   125                                                      
REMARK 465     PHE A   126                                                      
REMARK 465     ARG A   127                                                      
REMARK 465     VAL A   128                                                      
REMARK 465     ASP A   129                                                      
REMARK 465     TYR A   130                                                      
REMARK 465     ILE A   131                                                      
REMARK 465     LEU A   132                                                      
REMARK 465     SER A   133                                                      
REMARK 465     VAL A   134                                                      
REMARK 465     MET A   135                                                      
REMARK 465     ASN A   136                                                      
REMARK 465     VAL A   137                                                      
REMARK 465     PRO A   138                                                      
REMARK 465     ASP A   139                                                      
REMARK 465     PHE A   140                                                      
REMARK 465     ASP A   141                                                      
REMARK 465     PHE A   142                                                      
REMARK 465     PRO A   143                                                      
REMARK 465     PRO A   144                                                      
REMARK 465     GLU A   145                                                      
REMARK 465     PHE A   146                                                      
REMARK 465     TYR A   147                                                      
REMARK 465     GLU A   148                                                      
REMARK 465     HIS A   149                                                      
REMARK 465     ALA A   150                                                      
REMARK 465     LYS A   151                                                      
REMARK 465     ALA A   152                                                      
REMARK 465     LEU A   153                                                      
REMARK 465     TRP A   154                                                      
REMARK 465     GLU A   155                                                      
REMARK 465     ASP A   156                                                      
REMARK 465     GLU A   157                                                      
REMARK 465     GLY A   158                                                      
REMARK 465     VAL A   159                                                      
REMARK 465     ARG A   160                                                      
REMARK 465     ALA A   161                                                      
REMARK 465     CYS A   162                                                      
REMARK 465     TYR A   163                                                      
REMARK 465     GLU A   164                                                      
REMARK 465     ARG A   165                                                      
REMARK 465     SER A   166                                                      
REMARK 465     ASN A   167                                                      
REMARK 465     GLU A   168                                                      
REMARK 465     TYR A   169                                                      
REMARK 465     GLN A   170                                                      
REMARK 465     LEU A   171                                                      
REMARK 465     ILE A   172                                                      
REMARK 465     ASP A   173                                                      
REMARK 465     CYS A   174                                                      
REMARK 465     ALA A   175                                                      
REMARK 465     GLN A   176                                                      
REMARK 465     TYR A   177                                                      
REMARK 465     PHE A   178                                                      
REMARK 465     LEU A   179                                                      
REMARK 465     ASP A   180                                                      
REMARK 465     LYS A   181                                                      
REMARK 465     ILE A   182                                                      
REMARK 465     ASP A   183                                                      
REMARK 465     VAL A   184                                                      
REMARK 465     ILE A   185                                                      
REMARK 465     LYS A   186                                                      
REMARK 465     GLN A   187                                                      
REMARK 465     ALA A   188                                                      
REMARK 465     ASP A   189                                                      
REMARK 465     TYR A   190                                                      
REMARK 465     VAL A   191                                                      
REMARK 465     PRO A   192                                                      
REMARK 465     SER A   193                                                      
REMARK 465     ASP A   194                                                      
REMARK 465     GLN A   195                                                      
REMARK 465     ASP A   196                                                      
REMARK 465     LEU A   197                                                      
REMARK 465     LEU A   198                                                      
REMARK 465     ARG A   199                                                      
REMARK 465     CYS A   200                                                      
REMARK 465     ARG A   201                                                      
REMARK 465     VAL A   202                                                      
REMARK 465     LEU A   203                                                      
REMARK 465     THR A   204                                                      
REMARK 465     SER A   252                                                      
REMARK 465     TYR A   253                                                      
REMARK 465     ASN A   254                                                      
REMARK 465     MET A   255                                                      
REMARK 465     VAL A   256                                                      
REMARK 465     ILE A   257                                                      
REMARK 465     ARG A   258                                                      
REMARK 465     GLU A   259                                                      
REMARK 465     ASP A   260                                                      
REMARK 465     ASN A   261                                                      
REMARK 465     LYS A   293                                                      
REMARK 465     GLN A   294                                                      
REMARK 465     ASP A   295                                                      
REMARK 465     LEU A   296                                                      
REMARK 465     LEU A   297                                                      
REMARK 465     ALA A   298                                                      
REMARK 465     GLU A   299                                                      
REMARK 465     LYS A   300                                                      
REMARK 465     VAL A   301                                                      
REMARK 465     LEU A   302                                                      
REMARK 465     ALA A   303                                                      
REMARK 465     GLY A   304                                                      
REMARK 465     LYS A   305                                                      
REMARK 465     SER A   306                                                      
REMARK 465     LYS A   307                                                      
REMARK 465     GLY A   353                                                      
REMARK 465     ASP A   354                                                      
REMARK 465     GLY A   355                                                      
REMARK 465     THR A   364                                                      
REMARK 465     CYS A   365                                                      
REMARK 465     ALA A   366                                                      
REMARK 465     VAL A   367                                                      
REMARK 465     ASP A   368                                                      
REMARK 465     THR A   369                                                      
REMARK 465     GLU A   370                                                      
REMARK 465     MET B    -9                                                      
REMARK 465     HIS B    -8                                                      
REMARK 465     HIS B    -7                                                      
REMARK 465     HIS B    -6                                                      
REMARK 465     HIS B    -5                                                      
REMARK 465     HIS B    -4                                                      
REMARK 465     HIS B    -3                                                      
REMARK 465     GLY B    -2                                                      
REMARK 465     SER B    -1                                                      
REMARK 465     SER B     0                                                      
REMARK 465     GLY B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     GLU B     3                                                      
REMARK 465     LEU B     4                                                      
REMARK 465     MET G     1                                                      
REMARK 465     ALA G     2                                                      
REMARK 465     SER G     3                                                      
REMARK 465     ASN G     4                                                      
REMARK 465     ASN G     5                                                      
REMARK 465     THR G     6                                                      
REMARK 465     ALA G     7                                                      
REMARK 465     SER G     8                                                      
REMARK 465     ILE G     9                                                      
REMARK 465     ALA G    10                                                      
REMARK 465     GLN G    11                                                      
REMARK 465     ALA G    12                                                      
REMARK 465     ARG G    13                                                      
REMARK 465     GLU G    63                                                      
REMARK 465     LYS G    64                                                      
REMARK 465     LYS G    65                                                      
REMARK 465     PHE G    66                                                      
REMARK 465     PHE G    67                                                      
REMARK 465     CYS G    68                                                      
REMARK 465     ALA G    69                                                      
REMARK 465     ILE G    70                                                      
REMARK 465     LEU G    71                                                      
REMARK 465     MET R    -9                                                      
REMARK 465     LYS R    -8                                                      
REMARK 465     THR R    -7                                                      
REMARK 465     ILE R    -6                                                      
REMARK 465     ILE R    -5                                                      
REMARK 465     ALA R    -4                                                      
REMARK 465     LEU R    -3                                                      
REMARK 465     SER R    -2                                                      
REMARK 465     TYR R    -1                                                      
REMARK 465     ILE R     0                                                      
REMARK 465     PHE R     1                                                      
REMARK 465     CYS R     2                                                      
REMARK 465     LEU R     3                                                      
REMARK 465     VAL R     4                                                      
REMARK 465     PHE R     5                                                      
REMARK 465     ALA R     6                                                      
REMARK 465     ASP R     7                                                      
REMARK 465     TYR R     8                                                      
REMARK 465     LYS R     9                                                      
REMARK 465     ASP R    10                                                      
REMARK 465     ASP R    11                                                      
REMARK 465     ASP R    12                                                      
REMARK 465     ASP R    13                                                      
REMARK 465     LEU R    14                                                      
REMARK 465     GLU R    15                                                      
REMARK 465     VAL R    16                                                      
REMARK 465     LEU R    17                                                      
REMARK 465     PHE R    18                                                      
REMARK 465     GLN R    19                                                      
REMARK 465     GLY R    20                                                      
REMARK 465     PRO R    21                                                      
REMARK 465     ALA R    22                                                      
REMARK 465     GLU R    23                                                      
REMARK 465     LEU R    24                                                      
REMARK 465     GLU R    25                                                      
REMARK 465     GLU R    26                                                      
REMARK 465     SER R    27                                                      
REMARK 465     PRO R    28                                                      
REMARK 465     GLU R    29                                                      
REMARK 465     ASP R    30                                                      
REMARK 465     SER R    31                                                      
REMARK 465     ILE R    32                                                      
REMARK 465     ASP R    55                                                      
REMARK 465     PRO R    56                                                      
REMARK 465     ILE R    57                                                      
REMARK 465     GLN R    58                                                      
REMARK 465     GLN R    59                                                      
REMARK 465     ALA R    60                                                      
REMARK 465     GLU R    61                                                      
REMARK 465     GLY R    62                                                      
REMARK 465     VAL R    63                                                      
REMARK 465     GLN R   107                                                      
REMARK 465     ASP R   108                                                      
REMARK 465     GLY R   109                                                      
REMARK 465     HIS R   324                                                      
REMARK 465     GLN R   325                                                      
REMARK 465     ALA R   326                                                      
REMARK 465     GLU R   327                                                      
REMARK 465     SER R   328                                                      
REMARK 465     PRO R   356                                                      
REMARK 465     GLU R   357                                                      
REMARK 465     GLY R   358                                                      
REMARK 465     LYS R   359                                                      
REMARK 465     ILE R   360                                                      
REMARK 465     ALA R   361                                                      
REMARK 465     GLU R   362                                                      
REMARK 465     LYS R   403                                                      
REMARK 465     ILE R   404                                                      
REMARK 465     GLN R   405                                                      
REMARK 465     PHE R   406                                                      
REMARK 465     GLY R   407                                                      
REMARK 465     ASN R   408                                                      
REMARK 465     SER R   409                                                      
REMARK 465     PHE R   410                                                      
REMARK 465     SER R   411                                                      
REMARK 465     ASN R   412                                                      
REMARK 465     SER R   413                                                      
REMARK 465     GLU R   414                                                      
REMARK 465     ALA R   415                                                      
REMARK 465     LEU R   416                                                      
REMARK 465     ARG R   417                                                      
REMARK 465     SER R   418                                                      
REMARK 465     ALA R   419                                                      
REMARK 465     SER R   420                                                      
REMARK 465     TYR R   421                                                      
REMARK 465     THR R   422                                                      
REMARK 465     VAL R   423                                                      
REMARK 465     SER R   424                                                      
REMARK 465     THR R   425                                                      
REMARK 465     ILE R   426                                                      
REMARK 465     SER R   427                                                      
REMARK 465     ASP R   428                                                      
REMARK 465     GLY R   429                                                      
REMARK 465     PRO R   430                                                      
REMARK 465     GLY R   431                                                      
REMARK 465     TYR R   432                                                      
REMARK 465     SER R   433                                                      
REMARK 465     HIS R   434                                                      
REMARK 465     ASP R   435                                                      
REMARK 465     CYS R   436                                                      
REMARK 465     PRO R   437                                                      
REMARK 465     SER R   438                                                      
REMARK 465     GLU R   439                                                      
REMARK 465     HIS R   440                                                      
REMARK 465     LEU R   441                                                      
REMARK 465     ASN R   442                                                      
REMARK 465     GLY R   443                                                      
REMARK 465     LYS R   444                                                      
REMARK 465     SER R   445                                                      
REMARK 465     ILE R   446                                                      
REMARK 465     HIS R   447                                                      
REMARK 465     ASP R   448                                                      
REMARK 465     ILE R   449                                                      
REMARK 465     GLU R   450                                                      
REMARK 465     ASN R   451                                                      
REMARK 465     VAL R   452                                                      
REMARK 465     LEU R   453                                                      
REMARK 465     LEU R   454                                                      
REMARK 465     LYS R   455                                                      
REMARK 465     PRO R   456                                                      
REMARK 465     GLU R   457                                                      
REMARK 465     ASN R   458                                                      
REMARK 465     LEU R   459                                                      
REMARK 465     TYR R   460                                                      
REMARK 465     ASN R   461                                                      
REMARK 465     PRO R   462                                                      
REMARK 465     ALA R   463                                                      
REMARK 465     GLY R   464                                                      
REMARK 465     LEU R   465                                                      
REMARK 465     GLU R   466                                                      
REMARK 465     VAL R   467                                                      
REMARK 465     LEU R   468                                                      
REMARK 465     PHE R   469                                                      
REMARK 465     GLN R   470                                                      
REMARK 465     GLY R   471                                                      
REMARK 465     PRO R   472                                                      
REMARK 465     HIS R   473                                                      
REMARK 465     HIS R   474                                                      
REMARK 465     HIS R   475                                                      
REMARK 465     HIS R   476                                                      
REMARK 465     HIS R   477                                                      
REMARK 465     HIS R   478                                                      
REMARK 465     HIS R   479                                                      
REMARK 465     HIS R   480                                                      
REMARK 465     MET E     0                                                      
REMARK 465     LYS E     1                                                      
REMARK 465     THR E     2                                                      
REMARK 465     ILE E     3                                                      
REMARK 465     ILE E     4                                                      
REMARK 465     ALA E     5                                                      
REMARK 465     LEU E     6                                                      
REMARK 465     SER E     7                                                      
REMARK 465     TYR E     8                                                      
REMARK 465     ILE E     9                                                      
REMARK 465     PHE E    10                                                      
REMARK 465     CYS E    11                                                      
REMARK 465     LEU E    12                                                      
REMARK 465     VAL E    13                                                      
REMARK 465     PHE E    14                                                      
REMARK 465     ALA E    15                                                      
REMARK 465     ASP E    16                                                      
REMARK 465     TYR E    17                                                      
REMARK 465     LYS E    18                                                      
REMARK 465     ASP E    19                                                      
REMARK 465     ASP E    20                                                      
REMARK 465     ASP E    21                                                      
REMARK 465     ASP E    22                                                      
REMARK 465     LYS E    23                                                      
REMARK 465     HIS E    24                                                      
REMARK 465     GLY E    25                                                      
REMARK 465     SER E    26                                                      
REMARK 465     CYS E    27                                                      
REMARK 465     GLN E    28                                                      
REMARK 465     THR E   144                                                      
REMARK 465     GLU E   145                                                      
REMARK 465     GLY E   146                                                      
REMARK 465     ILE E   147                                                      
REMARK 465     VAL E   148                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU A 322    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 323    CG   OD1  OD2                                       
REMARK 470     THR A 325    OG1  CG2                                            
REMARK 470     GLU A 327    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 330    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 331    CG   OD1  OD2                                       
REMARK 470     ASP B   5    CG   OD1  OD2                                       
REMARK 470     GLN B   6    CG   CD   OE1  NE2                                  
REMARK 470     ARG B   8    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN B   9    CG   CD   OE1  NE2                                  
REMARK 470     GLU B  10    CG   CD   OE1  OE2                                  
REMARK 470     GLU B  12    CG   CD   OE1  OE2                                  
REMARK 470     LYS B  15    CG   CD   CE   NZ                                   
REMARK 470     GLN B  17    CG   CD   OE1  NE2                                  
REMARK 470     ARG B 129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G  14    CG   CD   CE   NZ                                   
REMARK 470     LYS G  20    CG   CD   CE   NZ                                   
REMARK 470     LYS R 167    CG   CD   CE   NZ                                   
REMARK 470     GLU R 248    CG   CD   OE1  OE2                                  
REMARK 470     LYS R 249    CG   CD   CE   NZ                                   
REMARK 470     GLN R 250    CG   CD   OE1  NE2                                  
REMARK 470     ASN R 329    CG   OD1  ND2                                       
REMARK 470     ARG R 355    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E 112    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN N  77       47.13     34.69                                   
REMARK 500    ASP N  90       31.65    -96.81                                   
REMARK 500    PHE A 238       30.81    -95.06                                   
REMARK 500    THR B  87       41.41     38.62                                   
REMARK 500    SER B 136      -62.04    -91.57                                   
REMARK 500    THR B 164       -7.60     73.11                                   
REMARK 500    ASP B 291       38.02    -97.95                                   
REMARK 500    SER R 168       -4.44   -140.05                                   
REMARK 500    ALA R 244       51.44   -118.57                                   
REMARK 500    TYR R 277      -73.67   -108.88                                   
REMARK 500    LYS R 321       32.07    -98.85                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8978   RELATED DB: EMDB                              
REMARK 900 CRYO-EM STRUCTURE OF THE ACTIVE, GS-PROTEIN COMPLEXED, HUMAN CGRP    
REMARK 900 RECEPTOR                                                             
DBREF  6E3Y P    1    37  UNP    P06881   CALCA_HUMAN     83    119             
DBREF  6E3Y N    1   138  PDB    6E3Y     6E3Y             1    138             
DBREF  6E3Y A    1   394  UNP    P63092   GNAS2_HUMAN      1    394             
DBREF  6E3Y B    2   340  UNP    P62873   GBB1_HUMAN       2    340             
DBREF  6E3Y G    1    71  UNP    P59768   GBG2_HUMAN       1     71             
DBREF  6E3Y R   22   461  UNP    Q16602   CALRL_HUMAN     22    461             
DBREF  6E3Y E   27   148  UNP    O60894   RAMP1_HUMAN     27    148             
SEQADV 6E3Y NH2 P   38  UNP  P06881              AMIDATION                      
SEQADV 6E3Y ASN A   54  UNP  P63092    SER    54 ENGINEERED MUTATION            
SEQADV 6E3Y ALA A  226  UNP  P63092    GLY   226 ENGINEERED MUTATION            
SEQADV 6E3Y ALA A  268  UNP  P63092    GLU   268 ENGINEERED MUTATION            
SEQADV 6E3Y LYS A  271  UNP  P63092    ASN   271 ENGINEERED MUTATION            
SEQADV 6E3Y ASP A  274  UNP  P63092    LYS   274 ENGINEERED MUTATION            
SEQADV 6E3Y LYS A  280  UNP  P63092    ARG   280 ENGINEERED MUTATION            
SEQADV 6E3Y ASP A  284  UNP  P63092    THR   284 ENGINEERED MUTATION            
SEQADV 6E3Y THR A  285  UNP  P63092    ILE   285 ENGINEERED MUTATION            
SEQADV 6E3Y MET B   -9  UNP  P62873              INITIATING METHIONINE          
SEQADV 6E3Y HIS B   -8  UNP  P62873              EXPRESSION TAG                 
SEQADV 6E3Y HIS B   -7  UNP  P62873              EXPRESSION TAG                 
SEQADV 6E3Y HIS B   -6  UNP  P62873              EXPRESSION TAG                 
SEQADV 6E3Y HIS B   -5  UNP  P62873              EXPRESSION TAG                 
SEQADV 6E3Y HIS B   -4  UNP  P62873              EXPRESSION TAG                 
SEQADV 6E3Y HIS B   -3  UNP  P62873              EXPRESSION TAG                 
SEQADV 6E3Y GLY B   -2  UNP  P62873              EXPRESSION TAG                 
SEQADV 6E3Y SER B   -1  UNP  P62873              EXPRESSION TAG                 
SEQADV 6E3Y SER B    0  UNP  P62873              EXPRESSION TAG                 
SEQADV 6E3Y GLY B    1  UNP  P62873              EXPRESSION TAG                 
SEQADV 6E3Y MET R   -9  UNP  Q16602              INITIATING METHIONINE          
SEQADV 6E3Y LYS R   -8  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y THR R   -7  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ILE R   -6  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ILE R   -5  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ALA R   -4  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y LEU R   -3  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y SER R   -2  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y TYR R   -1  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ILE R    0  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y PHE R    1  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y CYS R    2  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y LEU R    3  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y VAL R    4  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y PHE R    5  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ALA R    6  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ASP R    7  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y TYR R    8  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y LYS R    9  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ASP R   10  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ASP R   11  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ASP R   12  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ASP R   13  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y LEU R   14  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y GLU R   15  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y VAL R   16  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y LEU R   17  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y PHE R   18  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y GLN R   19  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y GLY R   20  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y PRO R   21  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y PRO R  462  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y ALA R  463  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y GLY R  464  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y LEU R  465  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y GLU R  466  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y VAL R  467  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y LEU R  468  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y PHE R  469  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y GLN R  470  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y GLY R  471  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y PRO R  472  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y HIS R  473  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y HIS R  474  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y HIS R  475  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y HIS R  476  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y HIS R  477  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y HIS R  478  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y HIS R  479  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y HIS R  480  UNP  Q16602              EXPRESSION TAG                 
SEQADV 6E3Y MET E    0  UNP  O60894              INITIATING METHIONINE          
SEQADV 6E3Y LYS E    1  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y THR E    2  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y ILE E    3  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y ILE E    4  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y ALA E    5  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y LEU E    6  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y SER E    7  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y TYR E    8  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y ILE E    9  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y PHE E   10  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y CYS E   11  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y LEU E   12  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y VAL E   13  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y PHE E   14  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y ALA E   15  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y ASP E   16  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y TYR E   17  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y LYS E   18  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y ASP E   19  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y ASP E   20  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y ASP E   21  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y ASP E   22  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y LYS E   23  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y HIS E   24  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y GLY E   25  UNP  O60894              EXPRESSION TAG                 
SEQADV 6E3Y SER E   26  UNP  O60894              EXPRESSION TAG                 
SEQRES   1 P   38  ALA CYS ASP THR ALA THR CYS VAL THR HIS ARG LEU ALA          
SEQRES   2 P   38  GLY LEU LEU SER ARG SER GLY GLY VAL VAL LYS ASN ASN          
SEQRES   3 P   38  PHE VAL PRO THR ASN VAL GLY SER LYS ALA PHE NH2              
SEQRES   1 N  138  GLN VAL GLN LEU GLN GLU SER GLY GLY GLY LEU VAL GLN          
SEQRES   2 N  138  PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY          
SEQRES   3 N  138  PHE THR PHE SER ASN TYR LYS MET ASN TRP VAL ARG GLN          
SEQRES   4 N  138  ALA PRO GLY LYS GLY LEU GLU TRP VAL SER ASP ILE SER          
SEQRES   5 N  138  GLN SER GLY ALA SER ILE SER TYR THR GLY SER VAL LYS          
SEQRES   6 N  138  GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN THR          
SEQRES   7 N  138  LEU TYR LEU GLN MET ASN SER LEU LYS PRO GLU ASP THR          
SEQRES   8 N  138  ALA VAL TYR TYR CYS ALA ARG CYS PRO ALA PRO PHE THR          
SEQRES   9 N  138  ARG ASP CYS PHE ASP VAL THR SER THR THR TYR ALA TYR          
SEQRES  10 N  138  ARG GLY GLN GLY THR GLN VAL THR VAL SER SER HIS HIS          
SEQRES  11 N  138  HIS HIS HIS HIS GLU PRO GLU ALA                              
SEQRES   1 A  394  MET GLY CYS LEU GLY ASN SER LYS THR GLU ASP GLN ARG          
SEQRES   2 A  394  ASN GLU GLU LYS ALA GLN ARG GLU ALA ASN LYS LYS ILE          
SEQRES   3 A  394  GLU LYS GLN LEU GLN LYS ASP LYS GLN VAL TYR ARG ALA          
SEQRES   4 A  394  THR HIS ARG LEU LEU LEU LEU GLY ALA GLY GLU SER GLY          
SEQRES   5 A  394  LYS ASN THR ILE VAL LYS GLN MET ARG ILE LEU HIS VAL          
SEQRES   6 A  394  ASN GLY PHE ASN GLY GLU GLY GLY GLU GLU ASP PRO GLN          
SEQRES   7 A  394  ALA ALA ARG SER ASN SER ASP GLY GLU LYS ALA THR LYS          
SEQRES   8 A  394  VAL GLN ASP ILE LYS ASN ASN LEU LYS GLU ALA ILE GLU          
SEQRES   9 A  394  THR ILE VAL ALA ALA MET SER ASN LEU VAL PRO PRO VAL          
SEQRES  10 A  394  GLU LEU ALA ASN PRO GLU ASN GLN PHE ARG VAL ASP TYR          
SEQRES  11 A  394  ILE LEU SER VAL MET ASN VAL PRO ASP PHE ASP PHE PRO          
SEQRES  12 A  394  PRO GLU PHE TYR GLU HIS ALA LYS ALA LEU TRP GLU ASP          
SEQRES  13 A  394  GLU GLY VAL ARG ALA CYS TYR GLU ARG SER ASN GLU TYR          
SEQRES  14 A  394  GLN LEU ILE ASP CYS ALA GLN TYR PHE LEU ASP LYS ILE          
SEQRES  15 A  394  ASP VAL ILE LYS GLN ALA ASP TYR VAL PRO SER ASP GLN          
SEQRES  16 A  394  ASP LEU LEU ARG CYS ARG VAL LEU THR SER GLY ILE PHE          
SEQRES  17 A  394  GLU THR LYS PHE GLN VAL ASP LYS VAL ASN PHE HIS MET          
SEQRES  18 A  394  PHE ASP VAL GLY ALA GLN ARG ASP GLU ARG ARG LYS TRP          
SEQRES  19 A  394  ILE GLN CYS PHE ASN ASP VAL THR ALA ILE ILE PHE VAL          
SEQRES  20 A  394  VAL ALA SER SER SER TYR ASN MET VAL ILE ARG GLU ASP          
SEQRES  21 A  394  ASN GLN THR ASN ARG LEU GLN ALA ALA LEU LYS LEU PHE          
SEQRES  22 A  394  ASP SER ILE TRP ASN ASN LYS TRP LEU ARG ASP THR SER          
SEQRES  23 A  394  VAL ILE LEU PHE LEU ASN LYS GLN ASP LEU LEU ALA GLU          
SEQRES  24 A  394  LYS VAL LEU ALA GLY LYS SER LYS ILE GLU ASP TYR PHE          
SEQRES  25 A  394  PRO GLU PHE ALA ARG TYR THR THR PRO GLU ASP ALA THR          
SEQRES  26 A  394  PRO GLU PRO GLY GLU ASP PRO ARG VAL THR ARG ALA LYS          
SEQRES  27 A  394  TYR PHE ILE ARG ASP GLU PHE LEU ARG ILE SER THR ALA          
SEQRES  28 A  394  SER GLY ASP GLY ARG HIS TYR CYS TYR PRO HIS PHE THR          
SEQRES  29 A  394  CYS ALA VAL ASP THR GLU ASN ILE ARG ARG VAL PHE ASN          
SEQRES  30 A  394  ASP CYS ARG ASP ILE ILE GLN ARG MET HIS LEU ARG GLN          
SEQRES  31 A  394  TYR GLU LEU LEU                                              
SEQRES   1 B  350  MET HIS HIS HIS HIS HIS HIS GLY SER SER GLY SER GLU          
SEQRES   2 B  350  LEU ASP GLN LEU ARG GLN GLU ALA GLU GLN LEU LYS ASN          
SEQRES   3 B  350  GLN ILE ARG ASP ALA ARG LYS ALA CYS ALA ASP ALA THR          
SEQRES   4 B  350  LEU SER GLN ILE THR ASN ASN ILE ASP PRO VAL GLY ARG          
SEQRES   5 B  350  ILE GLN MET ARG THR ARG ARG THR LEU ARG GLY HIS LEU          
SEQRES   6 B  350  ALA LYS ILE TYR ALA MET HIS TRP GLY THR ASP SER ARG          
SEQRES   7 B  350  LEU LEU VAL SER ALA SER GLN ASP GLY LYS LEU ILE ILE          
SEQRES   8 B  350  TRP ASP SER TYR THR THR ASN LYS VAL HIS ALA ILE PRO          
SEQRES   9 B  350  LEU ARG SER SER TRP VAL MET THR CYS ALA TYR ALA PRO          
SEQRES  10 B  350  SER GLY ASN TYR VAL ALA CYS GLY GLY LEU ASP ASN ILE          
SEQRES  11 B  350  CYS SER ILE TYR ASN LEU LYS THR ARG GLU GLY ASN VAL          
SEQRES  12 B  350  ARG VAL SER ARG GLU LEU ALA GLY HIS THR GLY TYR LEU          
SEQRES  13 B  350  SER CYS CYS ARG PHE LEU ASP ASP ASN GLN ILE VAL THR          
SEQRES  14 B  350  SER SER GLY ASP THR THR CYS ALA LEU TRP ASP ILE GLU          
SEQRES  15 B  350  THR GLY GLN GLN THR THR THR PHE THR GLY HIS THR GLY          
SEQRES  16 B  350  ASP VAL MET SER LEU SER LEU ALA PRO ASP THR ARG LEU          
SEQRES  17 B  350  PHE VAL SER GLY ALA CYS ASP ALA SER ALA LYS LEU TRP          
SEQRES  18 B  350  ASP VAL ARG GLU GLY MET CYS ARG GLN THR PHE THR GLY          
SEQRES  19 B  350  HIS GLU SER ASP ILE ASN ALA ILE CYS PHE PHE PRO ASN          
SEQRES  20 B  350  GLY ASN ALA PHE ALA THR GLY SER ASP ASP ALA THR CYS          
SEQRES  21 B  350  ARG LEU PHE ASP LEU ARG ALA ASP GLN GLU LEU MET THR          
SEQRES  22 B  350  TYR SER HIS ASP ASN ILE ILE CYS GLY ILE THR SER VAL          
SEQRES  23 B  350  SER PHE SER LYS SER GLY ARG LEU LEU LEU ALA GLY TYR          
SEQRES  24 B  350  ASP ASP PHE ASN CYS ASN VAL TRP ASP ALA LEU LYS ALA          
SEQRES  25 B  350  ASP ARG ALA GLY VAL LEU ALA GLY HIS ASP ASN ARG VAL          
SEQRES  26 B  350  SER CYS LEU GLY VAL THR ASP ASP GLY MET ALA VAL ALA          
SEQRES  27 B  350  THR GLY SER TRP ASP SER PHE LEU LYS ILE TRP ASN              
SEQRES   1 G   71  MET ALA SER ASN ASN THR ALA SER ILE ALA GLN ALA ARG          
SEQRES   2 G   71  LYS LEU VAL GLU GLN LEU LYS MET GLU ALA ASN ILE ASP          
SEQRES   3 G   71  ARG ILE LYS VAL SER LYS ALA ALA ALA ASP LEU MET ALA          
SEQRES   4 G   71  TYR CYS GLU ALA HIS ALA LYS GLU ASP PRO LEU LEU THR          
SEQRES   5 G   71  PRO VAL PRO ALA SER GLU ASN PRO PHE ARG GLU LYS LYS          
SEQRES   6 G   71  PHE PHE CYS ALA ILE LEU                                      
SEQRES   1 R  490  MET LYS THR ILE ILE ALA LEU SER TYR ILE PHE CYS LEU          
SEQRES   2 R  490  VAL PHE ALA ASP TYR LYS ASP ASP ASP ASP LEU GLU VAL          
SEQRES   3 R  490  LEU PHE GLN GLY PRO ALA GLU LEU GLU GLU SER PRO GLU          
SEQRES   4 R  490  ASP SER ILE GLN LEU GLY VAL THR ARG ASN LYS ILE MET          
SEQRES   5 R  490  THR ALA GLN TYR GLU CYS TYR GLN LYS ILE MET GLN ASP          
SEQRES   6 R  490  PRO ILE GLN GLN ALA GLU GLY VAL TYR CYS ASN ARG THR          
SEQRES   7 R  490  TRP ASP GLY TRP LEU CYS TRP ASN ASP VAL ALA ALA GLY          
SEQRES   8 R  490  THR GLU SER MET GLN LEU CYS PRO ASP TYR PHE GLN ASP          
SEQRES   9 R  490  PHE ASP PRO SER GLU LYS VAL THR LYS ILE CYS ASP GLN          
SEQRES  10 R  490  ASP GLY ASN TRP PHE ARG HIS PRO ALA SER ASN ARG THR          
SEQRES  11 R  490  TRP THR ASN TYR THR GLN CYS ASN VAL ASN THR HIS GLU          
SEQRES  12 R  490  LYS VAL LYS THR ALA LEU ASN LEU PHE TYR LEU THR ILE          
SEQRES  13 R  490  ILE GLY HIS GLY LEU SER ILE ALA SER LEU LEU ILE SER          
SEQRES  14 R  490  LEU GLY ILE PHE PHE TYR PHE LYS SER LEU SER CYS GLN          
SEQRES  15 R  490  ARG ILE THR LEU HIS LYS ASN LEU PHE PHE SER PHE VAL          
SEQRES  16 R  490  CYS ASN SER VAL VAL THR ILE ILE HIS LEU THR ALA VAL          
SEQRES  17 R  490  ALA ASN ASN GLN ALA LEU VAL ALA THR ASN PRO VAL SER          
SEQRES  18 R  490  CYS LYS VAL SER GLN PHE ILE HIS LEU TYR LEU MET GLY          
SEQRES  19 R  490  CYS ASN TYR PHE TRP MET LEU CYS GLU GLY ILE TYR LEU          
SEQRES  20 R  490  HIS THR LEU ILE VAL VAL ALA VAL PHE ALA GLU LYS GLN          
SEQRES  21 R  490  HIS LEU MET TRP TYR TYR PHE LEU GLY TRP GLY PHE PRO          
SEQRES  22 R  490  LEU ILE PRO ALA CYS ILE HIS ALA ILE ALA ARG SER LEU          
SEQRES  23 R  490  TYR TYR ASN ASP ASN CYS TRP ILE SER SER ASP THR HIS          
SEQRES  24 R  490  LEU LEU TYR ILE ILE HIS GLY PRO ILE CYS ALA ALA LEU          
SEQRES  25 R  490  LEU VAL ASN LEU PHE PHE LEU LEU ASN ILE VAL ARG VAL          
SEQRES  26 R  490  LEU ILE THR LYS LEU LYS VAL THR HIS GLN ALA GLU SER          
SEQRES  27 R  490  ASN LEU TYR MET LYS ALA VAL ARG ALA THR LEU ILE LEU          
SEQRES  28 R  490  VAL PRO LEU LEU GLY ILE GLU PHE VAL LEU ILE PRO TRP          
SEQRES  29 R  490  ARG PRO GLU GLY LYS ILE ALA GLU GLU VAL TYR ASP TYR          
SEQRES  30 R  490  ILE MET HIS ILE LEU MET HIS PHE GLN GLY LEU LEU VAL          
SEQRES  31 R  490  SER THR ILE PHE CYS PHE PHE ASN GLY GLU VAL GLN ALA          
SEQRES  32 R  490  ILE LEU ARG ARG ASN TRP ASN GLN TYR LYS ILE GLN PHE          
SEQRES  33 R  490  GLY ASN SER PHE SER ASN SER GLU ALA LEU ARG SER ALA          
SEQRES  34 R  490  SER TYR THR VAL SER THR ILE SER ASP GLY PRO GLY TYR          
SEQRES  35 R  490  SER HIS ASP CYS PRO SER GLU HIS LEU ASN GLY LYS SER          
SEQRES  36 R  490  ILE HIS ASP ILE GLU ASN VAL LEU LEU LYS PRO GLU ASN          
SEQRES  37 R  490  LEU TYR ASN PRO ALA GLY LEU GLU VAL LEU PHE GLN GLY          
SEQRES  38 R  490  PRO HIS HIS HIS HIS HIS HIS HIS HIS                          
SEQRES   1 E  149  MET LYS THR ILE ILE ALA LEU SER TYR ILE PHE CYS LEU          
SEQRES   2 E  149  VAL PHE ALA ASP TYR LYS ASP ASP ASP ASP LYS HIS GLY          
SEQRES   3 E  149  SER CYS GLN GLU ALA ASN TYR GLY ALA LEU LEU ARG GLU          
SEQRES   4 E  149  LEU CYS LEU THR GLN PHE GLN VAL ASP MET GLU ALA VAL          
SEQRES   5 E  149  GLY GLU THR LEU TRP CYS ASP TRP GLY ARG THR ILE ARG          
SEQRES   6 E  149  SER TYR ARG GLU LEU ALA ASP CYS THR TRP HIS MET ALA          
SEQRES   7 E  149  GLU LYS LEU GLY CYS PHE TRP PRO ASN ALA GLU VAL ASP          
SEQRES   8 E  149  ARG PHE PHE LEU ALA VAL HIS GLY ARG TYR PHE ARG SER          
SEQRES   9 E  149  CYS PRO ILE SER GLY ARG ALA VAL ARG ASP PRO PRO GLY          
SEQRES  10 E  149  SER ILE LEU TYR PRO PHE ILE VAL VAL PRO ILE THR VAL          
SEQRES  11 E  149  THR LEU LEU VAL THR ALA LEU VAL VAL TRP GLN SER LYS          
SEQRES  12 E  149  ARG THR GLU GLY ILE VAL                                      
HET    NH2  P  38       1                                                       
HETNAM     NH2 AMINO GROUP                                                      
FORMUL   1  NH2    H2 N                                                         
HELIX    1 AA1 CYS P    7  GLY P   20  1                                  14    
HELIX    2 AA2 THR N   28  TYR N   32  5                                   5    
HELIX    3 AA3 GLY N   62  LYS N   65  5                                   4    
HELIX    4 AA4 LYS N   87  THR N   91  5                                   5    
HELIX    5 AA5 GLU A   16  THR A   40  1                                  25    
HELIX    6 AA6 LYS A  233  VAL A  241  5                                   9    
HELIX    7 AA7 ASN A  264  ASN A  278  1                                  15    
HELIX    8 AA8 PHE A  312  ALA A  316  5                                   5    
HELIX    9 AA9 ASP A  331  ALA A  351  1                                  21    
HELIX   10 AB1 ILE A  372  TYR A  391  1                                  20    
HELIX   11 AB2 GLN B    6  ALA B   26  1                                  21    
HELIX   12 AB3 THR B   29  THR B   34  1                                   6    
HELIX   13 AB4 LEU G   15  ASN G   24  1                                  10    
HELIX   14 AB5 LYS G   29  HIS G   44  1                                  16    
HELIX   15 AB6 ALA G   45  ASP G   48  5                                   4    
HELIX   16 AB7 LEU R   34  GLN R   54  1                                  21    
HELIX   17 AB8 THR R  125  ASN R  130  1                                   6    
HELIX   18 AB9 ASN R  130  LYS R  167  1                                  38    
HELIX   19 AC1 CYS R  171  VAL R  198  1                                  28    
HELIX   20 AC2 PRO R  209  VAL R  242  1                                  34    
HELIX   21 AC3 MET R  253  TRP R  260  1                                   8    
HELIX   22 AC4 PRO R  263  TYR R  277  1                                  15    
HELIX   23 AC5 ASP R  280  ILE R  284  5                                   5    
HELIX   24 AC6 LEU R  291  LYS R  321  1                                  31    
HELIX   25 AC7 LEU R  330  GLY R  346  1                                  17    
HELIX   26 AC8 ILE R  347  VAL R  350  5                                   4    
HELIX   27 AC9 VAL R  364  PHE R  375  1                                  12    
HELIX   28 AD1 PHE R  375  ILE R  383  1                                   9    
HELIX   29 AD2 ASN R  388  TRP R  399  1                                  12    
HELIX   30 AD3 ALA E   30  GLY E   52  1                                  23    
HELIX   31 AD4 GLU E   53  TRP E   56  5                                   4    
HELIX   32 AD5 ASP E   58  GLY E   81  1                                  24    
HELIX   33 AD6 ASN E   86  PHE E  101  1                                  16    
HELIX   34 AD7 ILE E  118  ARG E  143  1                                  26    
SHEET    1 AA1 4 GLN N   3  GLY N   8  0                                        
SHEET    2 AA1 4 LEU N  18  SER N  25 -1  O  ALA N  23   N  GLN N   5           
SHEET    3 AA1 4 THR N  78  MET N  83 -1  O  LEU N  81   N  LEU N  20           
SHEET    4 AA1 4 PHE N  68  ASP N  73 -1  N  THR N  69   O  GLN N  82           
SHEET    1 AA2 6 GLY N  10  LEU N  11  0                                        
SHEET    2 AA2 6 THR N 122  THR N 125  1  O  GLN N 123   N  GLY N  10           
SHEET    3 AA2 6 ALA N  92  ARG N  98 -1  N  TYR N  94   O  THR N 122           
SHEET    4 AA2 6 MET N  34  GLN N  39 -1  N  ASN N  35   O  ALA N  97           
SHEET    5 AA2 6 LEU N  45  ILE N  51 -1  O  GLU N  46   N  ARG N  38           
SHEET    6 AA2 6 ILE N  58  TYR N  60 -1  O  SER N  59   N  ASP N  50           
SHEET    1 AA3 6 ILE A 207  GLN A 213  0                                        
SHEET    2 AA3 6 ASN A 218  VAL A 224 -1  O  ASP A 223   N  PHE A 208           
SHEET    3 AA3 6 HIS A  41  LEU A  46  1  N  LEU A  45   O  PHE A 222           
SHEET    4 AA3 6 ALA A 243  VAL A 248  1  O  ILE A 245   N  LEU A  44           
SHEET    5 AA3 6 SER A 286  LEU A 291  1  O  ILE A 288   N  PHE A 246           
SHEET    6 AA3 6 CYS A 359  TYR A 360  1  O  TYR A 360   N  LEU A 289           
SHEET    1 AA4 4 ARG B  46  LEU B  51  0                                        
SHEET    2 AA4 4 LEU B 336  ASN B 340 -1  O  ILE B 338   N  ARG B  48           
SHEET    3 AA4 4 VAL B 327  SER B 331 -1  N  VAL B 327   O  TRP B 339           
SHEET    4 AA4 4 VAL B 315  VAL B 320 -1  N  SER B 316   O  GLY B 330           
SHEET    1 AA5 4 ILE B  58  HIS B  62  0                                        
SHEET    2 AA5 4 LEU B  69  SER B  74 -1  O  VAL B  71   N  HIS B  62           
SHEET    3 AA5 4 LYS B  78  ASP B  83 -1  O  ILE B  80   N  SER B  72           
SHEET    4 AA5 4 ASN B  88  PRO B  94 -1  O  ASN B  88   N  ASP B  83           
SHEET    1 AA6 4 VAL B 100  TYR B 105  0                                        
SHEET    2 AA6 4 TYR B 111  GLY B 116 -1  O  ALA B 113   N  ALA B 104           
SHEET    3 AA6 4 CYS B 121  ASN B 125 -1  O  TYR B 124   N  VAL B 112           
SHEET    4 AA6 4 VAL B 135  LEU B 139 -1  O  SER B 136   N  ILE B 123           
SHEET    1 AA7 4 LEU B 146  PHE B 151  0                                        
SHEET    2 AA7 4 GLN B 156  SER B 161 -1  O  SER B 160   N  CYS B 148           
SHEET    3 AA7 4 CYS B 166  ASP B 170 -1  O  TRP B 169   N  ILE B 157           
SHEET    4 AA7 4 GLN B 176  PHE B 180 -1  O  THR B 177   N  LEU B 168           
SHEET    1 AA8 4 VAL B 187  LEU B 192  0                                        
SHEET    2 AA8 4 LEU B 198  ALA B 203 -1  O  GLY B 202   N  SER B 189           
SHEET    3 AA8 4 ALA B 208  ASP B 212 -1  O  TRP B 211   N  PHE B 199           
SHEET    4 AA8 4 CYS B 218  PHE B 222 -1  O  ARG B 219   N  LEU B 210           
SHEET    1 AA9 4 ILE B 229  PHE B 234  0                                        
SHEET    2 AA9 4 ALA B 240  SER B 245 -1  O  GLY B 244   N  ALA B 231           
SHEET    3 AA9 4 CYS B 250  ASP B 254 -1  O  PHE B 253   N  PHE B 241           
SHEET    4 AA9 4 GLN B 259  TYR B 264 -1  O  LEU B 261   N  LEU B 252           
SHEET    1 AB1 4 SER B 275  PHE B 278  0                                        
SHEET    2 AB1 4 LEU B 284  GLY B 288 -1  O  GLY B 288   N  SER B 275           
SHEET    3 AB1 4 CYS B 294  ASP B 298 -1  O  TRP B 297   N  LEU B 285           
SHEET    4 AB1 4 ARG B 304  LEU B 308 -1  O  GLY B 306   N  VAL B 296           
SHEET    1 AB2 2 THR R  68  TRP R  69  0                                        
SHEET    2 AB2 2 CYS R  74  TRP R  75 -1  O  TRP R  75   N  THR R  68           
SHEET    1 AB3 2 THR R  82  LEU R  87  0                                        
SHEET    2 AB3 2 LYS R 100  CYS R 105 -1  O  LYS R 103   N  SER R  84           
SSBOND   1 CYS P    2    CYS P    7                          1555   1555  2.03  
SSBOND   2 CYS N   22    CYS N   96                          1555   1555  2.03  
SSBOND   3 CYS N   99    CYS N  107                          1555   1555  2.02  
SSBOND   4 CYS R   48    CYS R   74                          1555   1555  2.03  
SSBOND   5 CYS R   65    CYS R  105                          1555   1555  2.03  
SSBOND   6 CYS R   88    CYS R  127                          1555   1555  2.03  
SSBOND   7 CYS R  212    CYS R  282                          1555   1555  2.03  
SSBOND   8 CYS E   40    CYS E   72                          1555   1555  2.03  
SSBOND   9 CYS E   57    CYS E  104                          1555   1555  2.03  
LINK         C   PHE P  37                 N   NH2 P  38     1555   1555  1.32  
CISPEP   1 TRP E   84    PRO E   85          0        -5.40                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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