GenomeNet

Database: PDB
Entry: 6FMQ
LinkDB: 6FMQ
Original site: 6FMQ 
HEADER    PEPTIDE BINDING PROTEIN                 02-FEB-18   6FMQ              
TITLE     KEAP1 - PEPTIDE COMPLEX                                               
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: KELCH-LIKE ECH-ASSOCIATED PROTEIN 1;                       
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: CYTOSOLIC INHIBITOR OF NRF2,INRF2,KELCH-LIKE PROTEIN 19;    
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: ACY-SC1-GLU-THR-GLY-GLU-LEU;                               
COMPND   8 CHAIN: D;                                                            
COMPND   9 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: KEAP1, INRF2, KIAA0132, KLHL19;                                
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 SYNTHETIC: YES;                                                      
SOURCE  10 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE  11 ORGANISM_TAXID: 32630                                                
KEYWDS    KEAP1, KELCH-DOMAIN, NRF2, NEURODEGENERATIVE, INHIBITOR, PEPTIDE      
KEYWDS   2 BINDING PROTEIN                                                      
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    S.K.TALAPATRA,F.KOZIELSKI,G.WELLS,N.D.GEORGAKOPOULOS                  
REVDAT   3   17-JAN-24 6FMQ    1       REMARK LINK                              
REVDAT   2   12-SEP-18 6FMQ    1       JRNL                                     
REVDAT   1   08-AUG-18 6FMQ    0                                                
JRNL        AUTH   N.D.GEORGAKOPOULOS,S.K.TALAPATRA,J.GATLIFF,F.KOZIELSKI,      
JRNL        AUTH 2 G.WELLS                                                      
JRNL        TITL   MODIFIED PEPTIDE INHIBITORS OF THE KEAP1-NRF2                
JRNL        TITL 2 PROTEIN-PROTEIN INTERACTION INCORPORATING UNNATURAL AMINO    
JRNL        TITL 3 ACIDS.                                                       
JRNL        REF    CHEMBIOCHEM                   V.  19  1810 2018              
JRNL        REFN                   ESSN 1439-7633                               
JRNL        PMID   29927029                                                     
JRNL        DOI    10.1002/CBIC.201800170                                       
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.10 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (1.13_2998: ???)                              
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.10                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.84                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.330                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.3                           
REMARK   3   NUMBER OF REFLECTIONS             : 71513                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.167                           
REMARK   3   R VALUE            (WORKING SET) : 0.165                           
REMARK   3   FREE R VALUE                     : 0.200                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.090                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 3639                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 47.8490 -  6.2168    0.99     2797   187  0.1740 0.2232        
REMARK   3     2  6.2168 -  4.9361    0.98     2686   133  0.1438 0.1987        
REMARK   3     3  4.9361 -  4.3126    0.99     2641   156  0.1109 0.1158        
REMARK   3     4  4.3126 -  3.9185    0.99     2640   153  0.1185 0.1451        
REMARK   3     5  3.9185 -  3.6377    0.99     2620   142  0.1372 0.1631        
REMARK   3     6  3.6377 -  3.4233    0.99     2631   143  0.1490 0.1940        
REMARK   3     7  3.4233 -  3.2519    1.00     2619   139  0.1615 0.1774        
REMARK   3     8  3.2519 -  3.1104    1.00     2638   142  0.1779 0.2425        
REMARK   3     9  3.1104 -  2.9907    1.00     2620   129  0.1881 0.2023        
REMARK   3    10  2.9907 -  2.8875    0.99     2628   117  0.1803 0.1891        
REMARK   3    11  2.8875 -  2.7972    0.97     2527   148  0.1768 0.2260        
REMARK   3    12  2.7972 -  2.7173    0.99     2573   153  0.1952 0.2533        
REMARK   3    13  2.7173 -  2.6457    1.00     2590   160  0.2037 0.2508        
REMARK   3    14  2.6457 -  2.5812    1.00     2600   142  0.2021 0.2706        
REMARK   3    15  2.5812 -  2.5225    1.00     2592   148  0.2122 0.2514        
REMARK   3    16  2.5225 -  2.4688    1.00     2589   150  0.2116 0.2492        
REMARK   3    17  2.4688 -  2.4195    1.00     2642   102  0.2101 0.2715        
REMARK   3    18  2.4195 -  2.3738    1.00     2592   138  0.2030 0.2378        
REMARK   3    19  2.3738 -  2.3314    1.00     2612   144  0.2092 0.2773        
REMARK   3    20  2.3314 -  2.2919    1.00     2593   108  0.2199 0.2649        
REMARK   3    21  2.2919 -  2.2549    1.00     2628   119  0.2245 0.2489        
REMARK   3    22  2.2549 -  2.2202    0.98     2553   133  0.2361 0.2872        
REMARK   3    23  2.2202 -  2.1876    0.98     2540   135  0.2492 0.2656        
REMARK   3    24  2.1876 -  2.1568    0.99     2569   142  0.2480 0.2641        
REMARK   3    25  2.1568 -  2.1276    1.00     2618   133  0.2500 0.2928        
REMARK   3    26  2.1276 -  2.1000    0.99     2536   143  0.2568 0.3067        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : NULL                                          
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.220            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 20.820           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.012           4725                                  
REMARK   3   ANGLE     :  1.203           6437                                  
REMARK   3   CHIRALITY :  0.086            676                                  
REMARK   3   PLANARITY :  0.007            868                                  
REMARK   3   DIHEDRAL  :  8.785           3621                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 6FMQ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 05-FEB-18.                  
REMARK 100 THE DEPOSITION ID IS D_1200008615.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 22-NOV-17                          
REMARK 200  TEMPERATURE           (KELVIN) : 180                                
REMARK 200  PH                             : 4.6                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : DIAMOND                            
REMARK 200  BEAMLINE                       : I03                                
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9660                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS3 S 6M              
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM                             
REMARK 200  DATA SCALING SOFTWARE          : SCALA                              
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 71681                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.100                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.6                               
REMARK 200  DATA REDUNDANCY                : 4.200                              
REMARK 200  R MERGE                    (I) : 0.06000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 11.9000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.10                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.21                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 3VNG                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 74.12                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.75                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 4.0 M AMMONIUM ACETATE, 0.1 M SODIUM     
REMARK 280  ACETATE TRIHYDRATE PH 4.6, VAPOR DIFFUSION, HANGING DROP,           
REMARK 280  TEMPERATURE 277K                                                    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X+1/2,-Y,Z+1/2                                         
REMARK 290       3555   -X,Y+1/2,-Z+1/2                                         
REMARK 290       4555   X+1/2,-Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       37.82600            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      105.56850            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       38.06450            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000      105.56850            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       37.82600            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       38.06450            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5680 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 21960 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -65.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, D                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   196                                                      
REMARK 465     ALA A   197                                                      
REMARK 465     MET A   198                                                      
REMARK 465     GLY A   199                                                      
REMARK 465     SER A   200                                                      
REMARK 465     SER A   201                                                      
REMARK 465     HIS A   202                                                      
REMARK 465     HIS A   203                                                      
REMARK 465     HIS A   204                                                      
REMARK 465     HIS A   205                                                      
REMARK 465     HIS A   206                                                      
REMARK 465     HIS A   207                                                      
REMARK 465     HIS A   208                                                      
REMARK 465     HIS A   209                                                      
REMARK 465     SER A   210                                                      
REMARK 465     SER A   211                                                      
REMARK 465     GLY A   212                                                      
REMARK 465     LEU A   213                                                      
REMARK 465     VAL A   214                                                      
REMARK 465     PRO A   215                                                      
REMARK 465     ARG A   216                                                      
REMARK 465     GLY A   217                                                      
REMARK 465     SER A   218                                                      
REMARK 465     HIS A   219                                                      
REMARK 465     MET A   220                                                      
REMARK 465     ALA A   221                                                      
REMARK 465     SER A   222                                                      
REMARK 465     MET A   223                                                      
REMARK 465     SER A   224                                                      
REMARK 465     ASP A   225                                                      
REMARK 465     SER A   226                                                      
REMARK 465     GLU A   227                                                      
REMARK 465     VAL A   228                                                      
REMARK 465     ASN A   229                                                      
REMARK 465     GLN A   230                                                      
REMARK 465     GLU A   231                                                      
REMARK 465     ALA A   232                                                      
REMARK 465     LYS A   233                                                      
REMARK 465     PRO A   234                                                      
REMARK 465     GLU A   235                                                      
REMARK 465     VAL A   236                                                      
REMARK 465     LYS A   237                                                      
REMARK 465     PRO A   238                                                      
REMARK 465     GLU A   239                                                      
REMARK 465     VAL A   240                                                      
REMARK 465     LYS A   241                                                      
REMARK 465     PRO A   242                                                      
REMARK 465     GLU A   243                                                      
REMARK 465     THR A   244                                                      
REMARK 465     HIS A   245                                                      
REMARK 465     ILE A   246                                                      
REMARK 465     ASN A   247                                                      
REMARK 465     LEU A   248                                                      
REMARK 465     LYS A   249                                                      
REMARK 465     VAL A   250                                                      
REMARK 465     SER A   251                                                      
REMARK 465     ASP A   252                                                      
REMARK 465     GLY A   253                                                      
REMARK 465     SER A   254                                                      
REMARK 465     SER A   255                                                      
REMARK 465     GLU A   256                                                      
REMARK 465     ILE A   257                                                      
REMARK 465     PHE A   258                                                      
REMARK 465     PHE A   259                                                      
REMARK 465     LYS A   260                                                      
REMARK 465     ILE A   261                                                      
REMARK 465     LYS A   262                                                      
REMARK 465     LYS A   263                                                      
REMARK 465     THR A   264                                                      
REMARK 465     THR A   265                                                      
REMARK 465     PRO A   266                                                      
REMARK 465     LEU A   267                                                      
REMARK 465     ARG A   268                                                      
REMARK 465     ARG A   269                                                      
REMARK 465     LEU A   270                                                      
REMARK 465     MET A   271                                                      
REMARK 465     GLU A   272                                                      
REMARK 465     ALA A   273                                                      
REMARK 465     PHE A   274                                                      
REMARK 465     ALA A   275                                                      
REMARK 465     LYS A   276                                                      
REMARK 465     ARG A   277                                                      
REMARK 465     GLN A   278                                                      
REMARK 465     GLY A   279                                                      
REMARK 465     LYS A   280                                                      
REMARK 465     GLU A   281                                                      
REMARK 465     MET A   282                                                      
REMARK 465     ASP A   283                                                      
REMARK 465     SER A   284                                                      
REMARK 465     LEU A   285                                                      
REMARK 465     ARG A   286                                                      
REMARK 465     PHE A   287                                                      
REMARK 465     LEU A   288                                                      
REMARK 465     TYR A   289                                                      
REMARK 465     ASP A   290                                                      
REMARK 465     GLY A   291                                                      
REMARK 465     ILE A   292                                                      
REMARK 465     ARG A   293                                                      
REMARK 465     ILE A   294                                                      
REMARK 465     GLN A   295                                                      
REMARK 465     ALA A   296                                                      
REMARK 465     ASP A   297                                                      
REMARK 465     GLN A   298                                                      
REMARK 465     THR A   299                                                      
REMARK 465     PRO A   300                                                      
REMARK 465     GLU A   301                                                      
REMARK 465     ASP A   302                                                      
REMARK 465     LEU A   303                                                      
REMARK 465     ASP A   304                                                      
REMARK 465     MET A   305                                                      
REMARK 465     GLU A   306                                                      
REMARK 465     ASP A   307                                                      
REMARK 465     ASN A   308                                                      
REMARK 465     ASP A   309                                                      
REMARK 465     ILE A   310                                                      
REMARK 465     ILE A   311                                                      
REMARK 465     GLU A   312                                                      
REMARK 465     ALA A   313                                                      
REMARK 465     HIS A   314                                                      
REMARK 465     ARG A   315                                                      
REMARK 465     GLU A   316                                                      
REMARK 465     GLN A   317                                                      
REMARK 465     ILE A   318                                                      
REMARK 465     GLY A   319                                                      
REMARK 465     GLY A   320                                                      
REMARK 465     ALA A   321                                                      
REMARK 465     PRO A   322                                                      
REMARK 465     LYS A   323                                                      
REMARK 465     VAL A   324                                                      
REMARK 465     MET B   196                                                      
REMARK 465     ALA B   197                                                      
REMARK 465     MET B   198                                                      
REMARK 465     GLY B   199                                                      
REMARK 465     SER B   200                                                      
REMARK 465     SER B   201                                                      
REMARK 465     HIS B   202                                                      
REMARK 465     HIS B   203                                                      
REMARK 465     HIS B   204                                                      
REMARK 465     HIS B   205                                                      
REMARK 465     HIS B   206                                                      
REMARK 465     HIS B   207                                                      
REMARK 465     HIS B   208                                                      
REMARK 465     HIS B   209                                                      
REMARK 465     SER B   210                                                      
REMARK 465     SER B   211                                                      
REMARK 465     GLY B   212                                                      
REMARK 465     LEU B   213                                                      
REMARK 465     VAL B   214                                                      
REMARK 465     PRO B   215                                                      
REMARK 465     ARG B   216                                                      
REMARK 465     GLY B   217                                                      
REMARK 465     SER B   218                                                      
REMARK 465     HIS B   219                                                      
REMARK 465     MET B   220                                                      
REMARK 465     ALA B   221                                                      
REMARK 465     SER B   222                                                      
REMARK 465     MET B   223                                                      
REMARK 465     SER B   224                                                      
REMARK 465     ASP B   225                                                      
REMARK 465     SER B   226                                                      
REMARK 465     GLU B   227                                                      
REMARK 465     VAL B   228                                                      
REMARK 465     ASN B   229                                                      
REMARK 465     GLN B   230                                                      
REMARK 465     GLU B   231                                                      
REMARK 465     ALA B   232                                                      
REMARK 465     LYS B   233                                                      
REMARK 465     PRO B   234                                                      
REMARK 465     GLU B   235                                                      
REMARK 465     VAL B   236                                                      
REMARK 465     LYS B   237                                                      
REMARK 465     PRO B   238                                                      
REMARK 465     GLU B   239                                                      
REMARK 465     VAL B   240                                                      
REMARK 465     LYS B   241                                                      
REMARK 465     PRO B   242                                                      
REMARK 465     GLU B   243                                                      
REMARK 465     THR B   244                                                      
REMARK 465     HIS B   245                                                      
REMARK 465     ILE B   246                                                      
REMARK 465     ASN B   247                                                      
REMARK 465     LEU B   248                                                      
REMARK 465     LYS B   249                                                      
REMARK 465     VAL B   250                                                      
REMARK 465     SER B   251                                                      
REMARK 465     ASP B   252                                                      
REMARK 465     GLY B   253                                                      
REMARK 465     SER B   254                                                      
REMARK 465     SER B   255                                                      
REMARK 465     GLU B   256                                                      
REMARK 465     ILE B   257                                                      
REMARK 465     PHE B   258                                                      
REMARK 465     PHE B   259                                                      
REMARK 465     LYS B   260                                                      
REMARK 465     ILE B   261                                                      
REMARK 465     LYS B   262                                                      
REMARK 465     LYS B   263                                                      
REMARK 465     THR B   264                                                      
REMARK 465     THR B   265                                                      
REMARK 465     PRO B   266                                                      
REMARK 465     LEU B   267                                                      
REMARK 465     ARG B   268                                                      
REMARK 465     ARG B   269                                                      
REMARK 465     LEU B   270                                                      
REMARK 465     MET B   271                                                      
REMARK 465     GLU B   272                                                      
REMARK 465     ALA B   273                                                      
REMARK 465     PHE B   274                                                      
REMARK 465     ALA B   275                                                      
REMARK 465     LYS B   276                                                      
REMARK 465     ARG B   277                                                      
REMARK 465     GLN B   278                                                      
REMARK 465     GLY B   279                                                      
REMARK 465     LYS B   280                                                      
REMARK 465     GLU B   281                                                      
REMARK 465     MET B   282                                                      
REMARK 465     ASP B   283                                                      
REMARK 465     SER B   284                                                      
REMARK 465     LEU B   285                                                      
REMARK 465     ARG B   286                                                      
REMARK 465     PHE B   287                                                      
REMARK 465     LEU B   288                                                      
REMARK 465     TYR B   289                                                      
REMARK 465     ASP B   290                                                      
REMARK 465     GLY B   291                                                      
REMARK 465     ILE B   292                                                      
REMARK 465     ARG B   293                                                      
REMARK 465     ILE B   294                                                      
REMARK 465     GLN B   295                                                      
REMARK 465     ALA B   296                                                      
REMARK 465     ASP B   297                                                      
REMARK 465     GLN B   298                                                      
REMARK 465     THR B   299                                                      
REMARK 465     PRO B   300                                                      
REMARK 465     GLU B   301                                                      
REMARK 465     ASP B   302                                                      
REMARK 465     LEU B   303                                                      
REMARK 465     ASP B   304                                                      
REMARK 465     MET B   305                                                      
REMARK 465     GLU B   306                                                      
REMARK 465     ASP B   307                                                      
REMARK 465     ASN B   308                                                      
REMARK 465     ASP B   309                                                      
REMARK 465     ILE B   310                                                      
REMARK 465     ILE B   311                                                      
REMARK 465     GLU B   312                                                      
REMARK 465     ALA B   313                                                      
REMARK 465     HIS B   314                                                      
REMARK 465     ARG B   315                                                      
REMARK 465     GLU B   316                                                      
REMARK 465     GLN B   317                                                      
REMARK 465     ILE B   318                                                      
REMARK 465     GLY B   319                                                      
REMARK 465     GLY B   320                                                      
REMARK 465     ALA B   321                                                      
REMARK 465     PRO B   322                                                      
REMARK 465     LYS B   323                                                      
REMARK 465     VAL B   324                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU A 446    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 551    CD   CE   NZ                                        
REMARK 480                                                                      
REMARK 480 ZERO OCCUPANCY ATOM                                                  
REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO                  
REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS                
REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;              
REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):         
REMARK 480   M RES C SSEQI ATOMS                                                
REMARK 480     ARG B  565   CZ                                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   NH1  ARG A   336     O    HOH A   801              1.70            
REMARK 500   O    HOH A   928     O    HOH A   951              1.95            
REMARK 500   O    HOH A   901     O    HOH A   951              1.98            
REMARK 500   NE   ARG B   336     O    HOH B   801              2.17            
REMARK 500   O    HOH B   872     O    HOH B   947              2.19            
REMARK 500   O    HOH A   911     O    HOH A   962              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ARG A 380   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.1 DEGREES          
REMARK 500    ARG A 494   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.6 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ARG A 336      -18.63     65.75                                   
REMARK 500    ARG A 336      -19.46     68.88                                   
REMARK 500    VAL A 453     -164.87   -115.93                                   
REMARK 500    THR A 481      -34.29   -131.04                                   
REMARK 500    GLN A 528      -68.91   -107.05                                   
REMARK 500    GLN A 528      -62.17   -107.05                                   
REMARK 500    VAL A 547     -167.74   -117.63                                   
REMARK 500    ARG B 336      -34.90     67.79                                   
REMARK 500    ASP B 385      -80.19    -26.64                                   
REMARK 500    VAL B 453     -167.36   -122.54                                   
REMARK 500    THR B 481      -54.16   -127.47                                   
REMARK 500    VAL B 547     -165.89   -115.95                                   
REMARK 500    HIS B 575      -33.17   -137.87                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              NA A 709  NA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HOH A 919   O                                                      
REMARK 620 2 HOH A 958   O    99.6                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              NA A 710  NA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HOH A 811   O                                                      
REMARK 620 2 HOH A 831   O   145.9                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              NA B 705  NA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 TYR B 334   OH                                                     
REMARK 620 2 ASN B 382   OD1 117.0                                              
REMARK 620 3 HOH B 889   O   125.1 101.2                                        
REMARK 620 4 HOH B 957   O   138.4  87.5  76.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              NA B 707  NA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HOH B 905   O                                                      
REMARK 620 2 HOH B 952   O   161.1                                              
REMARK 620 N                    1                                               
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 701                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO A 702                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ACT A 703                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ACT A 704                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ACT A 705                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ACT A 706                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ACT A 707                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NA A 708                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NA A 709                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NA A 710                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 701                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue EDO B 702                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ACT B 703                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ACT B 704                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NA B 705                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NA B 706                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NA B 707                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NA B 708                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residues ACE D 1 and DYW D 2      
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Di-peptide DYW D 2 and GLU D 3    
DBREF  6FMQ A  321   609  UNP    Q14145   KEAP1_HUMAN    321    609             
DBREF  6FMQ B  321   609  UNP    Q14145   KEAP1_HUMAN    321    609             
DBREF  6FMQ D    1     7  PDB    6FMQ     6FMQ             1      7             
SEQADV 6FMQ MET A  196  UNP  Q14145              INITIATING METHIONINE          
SEQADV 6FMQ ALA A  197  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET A  198  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY A  199  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  200  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  201  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  202  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  203  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  204  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  205  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  206  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  207  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  208  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  209  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  210  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  211  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY A  212  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU A  213  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ VAL A  214  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO A  215  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG A  216  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY A  217  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  218  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  219  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET A  220  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA A  221  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  222  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET A  223  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  224  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP A  225  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  226  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  227  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ VAL A  228  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASN A  229  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLN A  230  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  231  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA A  232  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS A  233  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO A  234  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  235  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ VAL A  236  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS A  237  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO A  238  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  239  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ VAL A  240  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS A  241  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO A  242  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  243  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ THR A  244  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  245  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE A  246  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASN A  247  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU A  248  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS A  249  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ VAL A  250  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  251  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP A  252  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY A  253  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  254  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  255  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  256  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE A  257  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PHE A  258  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PHE A  259  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS A  260  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE A  261  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS A  262  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS A  263  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ THR A  264  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ THR A  265  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO A  266  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU A  267  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG A  268  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG A  269  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU A  270  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET A  271  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  272  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA A  273  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PHE A  274  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA A  275  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS A  276  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG A  277  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLN A  278  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY A  279  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS A  280  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  281  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET A  282  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP A  283  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER A  284  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU A  285  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG A  286  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PHE A  287  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU A  288  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ TYR A  289  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP A  290  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY A  291  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE A  292  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG A  293  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE A  294  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLN A  295  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA A  296  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP A  297  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLN A  298  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ THR A  299  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO A  300  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  301  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP A  302  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU A  303  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP A  304  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET A  305  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  306  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP A  307  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASN A  308  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP A  309  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE A  310  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE A  311  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  312  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA A  313  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS A  314  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG A  315  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU A  316  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLN A  317  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE A  318  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY A  319  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY A  320  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET B  196  UNP  Q14145              INITIATING METHIONINE          
SEQADV 6FMQ ALA B  197  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET B  198  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY B  199  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  200  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  201  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  202  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  203  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  204  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  205  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  206  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  207  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  208  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  209  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  210  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  211  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY B  212  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU B  213  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ VAL B  214  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO B  215  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG B  216  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY B  217  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  218  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  219  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET B  220  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA B  221  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  222  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET B  223  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  224  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP B  225  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  226  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  227  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ VAL B  228  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASN B  229  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLN B  230  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  231  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA B  232  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS B  233  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO B  234  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  235  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ VAL B  236  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS B  237  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO B  238  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  239  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ VAL B  240  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS B  241  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO B  242  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  243  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ THR B  244  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  245  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE B  246  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASN B  247  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU B  248  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS B  249  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ VAL B  250  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  251  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP B  252  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY B  253  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  254  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  255  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  256  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE B  257  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PHE B  258  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PHE B  259  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS B  260  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE B  261  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS B  262  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS B  263  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ THR B  264  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ THR B  265  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO B  266  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU B  267  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG B  268  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG B  269  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU B  270  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET B  271  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  272  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA B  273  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PHE B  274  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA B  275  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS B  276  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG B  277  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLN B  278  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY B  279  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LYS B  280  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  281  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET B  282  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP B  283  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ SER B  284  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU B  285  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG B  286  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PHE B  287  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU B  288  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ TYR B  289  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP B  290  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY B  291  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE B  292  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG B  293  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE B  294  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLN B  295  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA B  296  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP B  297  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLN B  298  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ THR B  299  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ PRO B  300  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  301  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP B  302  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ LEU B  303  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP B  304  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ MET B  305  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  306  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP B  307  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASN B  308  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ASP B  309  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE B  310  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE B  311  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  312  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ALA B  313  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ HIS B  314  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ARG B  315  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLU B  316  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLN B  317  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ ILE B  318  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY B  319  UNP  Q14145              EXPRESSION TAG                 
SEQADV 6FMQ GLY B  320  UNP  Q14145              EXPRESSION TAG                 
SEQRES   1 A  414  MET ALA MET GLY SER SER HIS HIS HIS HIS HIS HIS HIS          
SEQRES   2 A  414  HIS SER SER GLY LEU VAL PRO ARG GLY SER HIS MET ALA          
SEQRES   3 A  414  SER MET SER ASP SER GLU VAL ASN GLN GLU ALA LYS PRO          
SEQRES   4 A  414  GLU VAL LYS PRO GLU VAL LYS PRO GLU THR HIS ILE ASN          
SEQRES   5 A  414  LEU LYS VAL SER ASP GLY SER SER GLU ILE PHE PHE LYS          
SEQRES   6 A  414  ILE LYS LYS THR THR PRO LEU ARG ARG LEU MET GLU ALA          
SEQRES   7 A  414  PHE ALA LYS ARG GLN GLY LYS GLU MET ASP SER LEU ARG          
SEQRES   8 A  414  PHE LEU TYR ASP GLY ILE ARG ILE GLN ALA ASP GLN THR          
SEQRES   9 A  414  PRO GLU ASP LEU ASP MET GLU ASP ASN ASP ILE ILE GLU          
SEQRES  10 A  414  ALA HIS ARG GLU GLN ILE GLY GLY ALA PRO LYS VAL GLY          
SEQRES  11 A  414  ARG LEU ILE TYR THR ALA GLY GLY TYR PHE ARG GLN SER          
SEQRES  12 A  414  LEU SER TYR LEU GLU ALA TYR ASN PRO SER ASP GLY THR          
SEQRES  13 A  414  TRP LEU ARG LEU ALA ASP LEU GLN VAL PRO ARG SER GLY          
SEQRES  14 A  414  LEU ALA GLY CYS VAL VAL GLY GLY LEU LEU TYR ALA VAL          
SEQRES  15 A  414  GLY GLY ARG ASN ASN SER PRO ASP GLY ASN THR ASP SER          
SEQRES  16 A  414  SER ALA LEU ASP CYS TYR ASN PRO MET THR ASN GLN TRP          
SEQRES  17 A  414  SER PRO CYS ALA PRO MET SER VAL PRO ARG ASN ARG ILE          
SEQRES  18 A  414  GLY VAL GLY VAL ILE ASP GLY HIS ILE TYR ALA VAL GLY          
SEQRES  19 A  414  GLY SER HIS GLY CYS ILE HIS HIS ASN SER VAL GLU ARG          
SEQRES  20 A  414  TYR GLU PRO GLU ARG ASP GLU TRP HIS LEU VAL ALA PRO          
SEQRES  21 A  414  MET LEU THR ARG ARG ILE GLY VAL GLY VAL ALA VAL LEU          
SEQRES  22 A  414  ASN ARG LEU LEU TYR ALA VAL GLY GLY PHE ASP GLY THR          
SEQRES  23 A  414  ASN ARG LEU ASN SER ALA GLU CYS TYR TYR PRO GLU ARG          
SEQRES  24 A  414  ASN GLU TRP ARG MET ILE THR ALA MET ASN THR ILE ARG          
SEQRES  25 A  414  SER GLY ALA GLY VAL CYS VAL LEU HIS ASN CYS ILE TYR          
SEQRES  26 A  414  ALA ALA GLY GLY TYR ASP GLY GLN ASP GLN LEU ASN SER          
SEQRES  27 A  414  VAL GLU ARG TYR ASP VAL GLU THR GLU THR TRP THR PHE          
SEQRES  28 A  414  VAL ALA PRO MET LYS HIS ARG ARG SER ALA LEU GLY ILE          
SEQRES  29 A  414  THR VAL HIS GLN GLY ARG ILE TYR VAL LEU GLY GLY TYR          
SEQRES  30 A  414  ASP GLY HIS THR PHE LEU ASP SER VAL GLU CYS TYR ASP          
SEQRES  31 A  414  PRO ASP THR ASP THR TRP SER GLU VAL THR ARG MET THR          
SEQRES  32 A  414  SER GLY ARG SER GLY VAL GLY VAL ALA VAL THR                  
SEQRES   1 B  414  MET ALA MET GLY SER SER HIS HIS HIS HIS HIS HIS HIS          
SEQRES   2 B  414  HIS SER SER GLY LEU VAL PRO ARG GLY SER HIS MET ALA          
SEQRES   3 B  414  SER MET SER ASP SER GLU VAL ASN GLN GLU ALA LYS PRO          
SEQRES   4 B  414  GLU VAL LYS PRO GLU VAL LYS PRO GLU THR HIS ILE ASN          
SEQRES   5 B  414  LEU LYS VAL SER ASP GLY SER SER GLU ILE PHE PHE LYS          
SEQRES   6 B  414  ILE LYS LYS THR THR PRO LEU ARG ARG LEU MET GLU ALA          
SEQRES   7 B  414  PHE ALA LYS ARG GLN GLY LYS GLU MET ASP SER LEU ARG          
SEQRES   8 B  414  PHE LEU TYR ASP GLY ILE ARG ILE GLN ALA ASP GLN THR          
SEQRES   9 B  414  PRO GLU ASP LEU ASP MET GLU ASP ASN ASP ILE ILE GLU          
SEQRES  10 B  414  ALA HIS ARG GLU GLN ILE GLY GLY ALA PRO LYS VAL GLY          
SEQRES  11 B  414  ARG LEU ILE TYR THR ALA GLY GLY TYR PHE ARG GLN SER          
SEQRES  12 B  414  LEU SER TYR LEU GLU ALA TYR ASN PRO SER ASP GLY THR          
SEQRES  13 B  414  TRP LEU ARG LEU ALA ASP LEU GLN VAL PRO ARG SER GLY          
SEQRES  14 B  414  LEU ALA GLY CYS VAL VAL GLY GLY LEU LEU TYR ALA VAL          
SEQRES  15 B  414  GLY GLY ARG ASN ASN SER PRO ASP GLY ASN THR ASP SER          
SEQRES  16 B  414  SER ALA LEU ASP CYS TYR ASN PRO MET THR ASN GLN TRP          
SEQRES  17 B  414  SER PRO CYS ALA PRO MET SER VAL PRO ARG ASN ARG ILE          
SEQRES  18 B  414  GLY VAL GLY VAL ILE ASP GLY HIS ILE TYR ALA VAL GLY          
SEQRES  19 B  414  GLY SER HIS GLY CYS ILE HIS HIS ASN SER VAL GLU ARG          
SEQRES  20 B  414  TYR GLU PRO GLU ARG ASP GLU TRP HIS LEU VAL ALA PRO          
SEQRES  21 B  414  MET LEU THR ARG ARG ILE GLY VAL GLY VAL ALA VAL LEU          
SEQRES  22 B  414  ASN ARG LEU LEU TYR ALA VAL GLY GLY PHE ASP GLY THR          
SEQRES  23 B  414  ASN ARG LEU ASN SER ALA GLU CYS TYR TYR PRO GLU ARG          
SEQRES  24 B  414  ASN GLU TRP ARG MET ILE THR ALA MET ASN THR ILE ARG          
SEQRES  25 B  414  SER GLY ALA GLY VAL CYS VAL LEU HIS ASN CYS ILE TYR          
SEQRES  26 B  414  ALA ALA GLY GLY TYR ASP GLY GLN ASP GLN LEU ASN SER          
SEQRES  27 B  414  VAL GLU ARG TYR ASP VAL GLU THR GLU THR TRP THR PHE          
SEQRES  28 B  414  VAL ALA PRO MET LYS HIS ARG ARG SER ALA LEU GLY ILE          
SEQRES  29 B  414  THR VAL HIS GLN GLY ARG ILE TYR VAL LEU GLY GLY TYR          
SEQRES  30 B  414  ASP GLY HIS THR PHE LEU ASP SER VAL GLU CYS TYR ASP          
SEQRES  31 B  414  PRO ASP THR ASP THR TRP SER GLU VAL THR ARG MET THR          
SEQRES  32 B  414  SER GLY ARG SER GLY VAL GLY VAL ALA VAL THR                  
SEQRES   1 D    7  ACE DYW GLU THR GLY GLU LEU                                  
HET    ACE  D   1       3                                                       
HET    DYW  D   2      15                                                       
HET    EDO  A 701       4                                                       
HET    EDO  A 702       4                                                       
HET    ACT  A 703       4                                                       
HET    ACT  A 704       4                                                       
HET    ACT  A 705       4                                                       
HET    ACT  A 706       4                                                       
HET    ACT  A 707       4                                                       
HET     NA  A 708       1                                                       
HET     NA  A 709       1                                                       
HET     NA  A 710       1                                                       
HET    EDO  B 701       4                                                       
HET    EDO  B 702       4                                                       
HET    ACT  B 703       4                                                       
HET    ACT  B 704       4                                                       
HET     NA  B 705       1                                                       
HET     NA  B 706       1                                                       
HET     NA  B 707       1                                                       
HET     NA  B 708       1                                                       
HETNAM     ACE ACETYL GROUP                                                     
HETNAM     DYW (2~{S})-1-[(2~{S})-2-AZANYL-4-OXIDANYL-4-OXIDANYLIDENE-          
HETNAM   2 DYW  BUTANOYL]PYRROLIDINE-2-CARBOXYLIC ACID                          
HETNAM     EDO 1,2-ETHANEDIOL                                                   
HETNAM     ACT ACETATE ION                                                      
HETNAM      NA SODIUM ION                                                       
HETSYN     EDO ETHYLENE GLYCOL                                                  
FORMUL   3  ACE    C2 H4 O                                                      
FORMUL   3  DYW    C9 H14 N2 O5                                                 
FORMUL   4  EDO    4(C2 H6 O2)                                                  
FORMUL   6  ACT    7(C2 H3 O2 1-)                                               
FORMUL  11   NA    7(NA 1+)                                                     
FORMUL  22  HOH   *356(H2 O)                                                    
SHEET    1 AA1 4 TRP A 352  ARG A 354  0                                        
SHEET    2 AA1 4 LEU A 342  TYR A 345 -1  N  ALA A 344   O  LEU A 353           
SHEET    3 AA1 4 LEU A 327  ALA A 331 -1  N  THR A 330   O  GLU A 343           
SHEET    4 AA1 4 GLY A 605  THR A 609 -1  O  THR A 609   N  LEU A 327           
SHEET    1 AA2 4 ALA A 366  VAL A 370  0                                        
SHEET    2 AA2 4 LEU A 373  VAL A 377 -1  O  TYR A 375   N  CYS A 368           
SHEET    3 AA2 4 LEU A 393  ASN A 397 -1  O  TYR A 396   N  LEU A 374           
SHEET    4 AA2 4 GLN A 402  PRO A 405 -1  O  SER A 404   N  CYS A 395           
SHEET    1 AA3 2 ARG A 380  SER A 383  0                                        
SHEET    2 AA3 2 GLY A 386  ASP A 389 -1  O  THR A 388   N  ASN A 381           
SHEET    1 AA4 4 GLY A 417  ILE A 421  0                                        
SHEET    2 AA4 4 HIS A 424  VAL A 428 -1  O  TYR A 426   N  GLY A 419           
SHEET    3 AA4 4 VAL A 440  GLU A 444 -1  O  GLU A 441   N  ALA A 427           
SHEET    4 AA4 4 GLU A 449  LEU A 452 -1  O  HIS A 451   N  ARG A 442           
SHEET    1 AA5 2 SER A 431  HIS A 432  0                                        
SHEET    2 AA5 2 ILE A 435  HIS A 436 -1  O  ILE A 435   N  HIS A 432           
SHEET    1 AA6 4 GLY A 464  LEU A 468  0                                        
SHEET    2 AA6 4 LEU A 471  PHE A 478 -1  O  TYR A 473   N  ALA A 466           
SHEET    3 AA6 4 ARG A 483  TYR A 491 -1  O  TYR A 490   N  LEU A 472           
SHEET    4 AA6 4 GLU A 496  ILE A 500 -1  O  ARG A 498   N  CYS A 489           
SHEET    1 AA7 4 GLY A 511  LEU A 515  0                                        
SHEET    2 AA7 4 CYS A 518  ALA A 522 -1  O  ALA A 522   N  GLY A 511           
SHEET    3 AA7 4 VAL A 534  ASP A 538 -1  O  TYR A 537   N  ILE A 519           
SHEET    4 AA7 4 THR A 543  VAL A 547 -1  O  VAL A 547   N  VAL A 534           
SHEET    1 AA8 4 GLY A 558  HIS A 562  0                                        
SHEET    2 AA8 4 ARG A 565  LEU A 569 -1  O  TYR A 567   N  THR A 560           
SHEET    3 AA8 4 SER A 580  ASP A 585 -1  O  TYR A 584   N  ILE A 566           
SHEET    4 AA8 4 THR A 590  ARG A 596 -1  O  SER A 592   N  CYS A 583           
SHEET    1 AA9 4 TRP B 352  ARG B 354  0                                        
SHEET    2 AA9 4 LEU B 342  TYR B 345 -1  N  ALA B 344   O  LEU B 353           
SHEET    3 AA9 4 LEU B 327  ALA B 331 -1  N  THR B 330   O  GLU B 343           
SHEET    4 AA9 4 GLY B 605  THR B 609 -1  O  ALA B 607   N  TYR B 329           
SHEET    1 AB1 4 ALA B 366  VAL B 370  0                                        
SHEET    2 AB1 4 LEU B 373  VAL B 377 -1  O  TYR B 375   N  CYS B 368           
SHEET    3 AB1 4 LEU B 393  ASN B 397 -1  O  TYR B 396   N  LEU B 374           
SHEET    4 AB1 4 GLN B 402  CYS B 406 -1  O  SER B 404   N  CYS B 395           
SHEET    1 AB2 2 ARG B 380  SER B 383  0                                        
SHEET    2 AB2 2 GLY B 386  ASP B 389 -1  O  THR B 388   N  ASN B 381           
SHEET    1 AB3 4 GLY B 417  ILE B 421  0                                        
SHEET    2 AB3 4 HIS B 424  VAL B 428 -1  O  TYR B 426   N  GLY B 419           
SHEET    3 AB3 4 VAL B 440  TYR B 443 -1  O  TYR B 443   N  ILE B 425           
SHEET    4 AB3 4 TRP B 450  LEU B 452 -1  O  HIS B 451   N  ARG B 442           
SHEET    1 AB4 2 SER B 431  HIS B 432  0                                        
SHEET    2 AB4 2 ILE B 435  HIS B 436 -1  O  ILE B 435   N  HIS B 432           
SHEET    1 AB5 4 GLY B 464  LEU B 468  0                                        
SHEET    2 AB5 4 LEU B 471  PHE B 478 -1  O  VAL B 475   N  GLY B 464           
SHEET    3 AB5 4 ARG B 483  TYR B 491 -1  O  TYR B 490   N  LEU B 472           
SHEET    4 AB5 4 GLU B 496  ILE B 500 -1  O  ARG B 498   N  CYS B 489           
SHEET    1 AB6 4 GLY B 511  LEU B 515  0                                        
SHEET    2 AB6 4 CYS B 518  ALA B 522 -1  O  TYR B 520   N  CYS B 513           
SHEET    3 AB6 4 VAL B 534  ASP B 538 -1  O  TYR B 537   N  ILE B 519           
SHEET    4 AB6 4 THR B 543  VAL B 547 -1  O  VAL B 547   N  VAL B 534           
SHEET    1 AB7 4 GLY B 558  HIS B 562  0                                        
SHEET    2 AB7 4 ARG B 565  LEU B 569 -1  O  TYR B 567   N  THR B 560           
SHEET    3 AB7 4 SER B 580  ASP B 585 -1  O  TYR B 584   N  ILE B 566           
SHEET    4 AB7 4 THR B 590  ARG B 596 -1  O  THR B 590   N  ASP B 585           
LINK         C   ACE D   1                 N53 DYW D   2     1555   1555  1.52  
LINK         C08 DYW D   2                 N   GLU D   3     1555   1555  1.47  
LINK        NA    NA A 708                 O  AASP B 385     1555   1555  3.08  
LINK        NA    NA A 709                 O   HOH A 919     1555   1555  2.98  
LINK        NA    NA A 709                 O   HOH A 958     1555   1555  2.12  
LINK        NA    NA A 710                 O   HOH A 811     1555   1555  2.06  
LINK        NA    NA A 710                 O   HOH A 831     1555   1555  2.53  
LINK         OH  TYR B 334                NA    NA B 705     1555   1555  2.85  
LINK         OD1 ASN B 382                NA    NA B 705     1555   1555  2.72  
LINK        NA    NA B 705                 O   HOH B 889     1555   1555  2.31  
LINK        NA    NA B 705                 O   HOH B 957     1555   1555  2.60  
LINK        NA    NA B 706                 O   HOH B 943     1555   1555  2.15  
LINK        NA    NA B 707                 O   HOH B 905     1555   1555  2.16  
LINK        NA    NA B 707                 O   HOH B 952     1555   1555  2.72  
LINK        NA    NA B 708                 O   HOH B 896     1555   1555  3.17  
SITE     1 AC1  5 ARG A 380  THR A 388  ASP A 389  GLY A 433                    
SITE     2 AC1  5 HOH A 817                                                     
SITE     1 AC2  3 ALA A 356  ASP A 357  ARG A 470                               
SITE     1 AC3  2 HIS A 432  HIS A 437                                          
SITE     1 AC4  6 LEU A 471  TYR A 491  PRO A 492  GLU A 493                    
SITE     2 AC4  6 ARG A 494  HOH A 842                                          
SITE     1 AC5  5 TYR A 334  ARG A 415  SER A 602  HOH A 803                    
SITE     2 AC5  5 HOH A 854                                                     
SITE     1 AC6  7 ARG A 415  PHE A 478  ARG A 483  SER A 508                    
SITE     2 AC6  7 HOH A 805  ASP B 385  GLY B 386                               
SITE     1 AC7  4 GLN A 337  ASN A 382  SER A 383  HOH A 809                    
SITE     1 AC8  3 ARG A 415  SER A 508  ASP B 385                               
SITE     1 AC9  4 SER A 390  SER A 391  HOH A 919  HOH A 958                    
SITE     1 AD1  4 MET A 399  TYR A 491  HOH A 811  HOH A 831                    
SITE     1 AD2  5 PHE A 478  GLY A 480  ASN B 387  THR B 388                    
SITE     2 AD2  5 ASP B 389                                                     
SITE     1 AD3  7 GLY B 364  ARG B 415  GLY B 509  ALA B 556                    
SITE     2 AD3  7 HOH B 808  HOH B 852  HOH B 903                               
SITE     1 AD4  6 LEU B 355  TYR B 491  PRO B 492  GLU B 493                    
SITE     2 AD4  6 ARG B 494  HOH B 822                                          
SITE     1 AD5  3 LEU B 355  ASP B 357  ARG B 470                               
SITE     1 AD6  5 TYR B 334  ARG B 336  ASN B 382  HOH B 889                    
SITE     2 AD6  5 HOH B 957                                                     
SITE     1 AD7  2 HIS B 432  HOH B 943                                          
SITE     1 AD8  3 HIS B 436  HOH B 905  HOH B 952                               
SITE     1 AD9  1 ARG B 380                                                     
SITE     1 AE1 11 GLY A 386  ASN A 387  TYR B 525  GLN B 530                    
SITE     2 AE1 11 SER B 555  TYR B 572  GLU D   3  THR D   4                    
SITE     3 AE1 11 GLY D   5  GLU D   6  HOH D 103                               
SITE     1 AE2 15 GLY A 386  ASN A 387  ARG B 415  ARG B 483                    
SITE     2 AE2 15 SER B 508  TYR B 525  GLN B 530  SER B 555                    
SITE     3 AE2 15 ALA B 556  TYR B 572  ACE D   1  THR D   4                    
SITE     4 AE2 15 GLY D   5  GLU D   6  HOH D 103                               
CRYST1   75.652   76.129  211.137  90.00  90.00  90.00 P 21 21 21    8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.013218  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.013136  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.004736        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system