GenomeNet

Database: PDB
Entry: 6G18
LinkDB: 6G18
Original site: 6G18 
HEADER    RIBOSOME                                20-MAR-18   6G18              
TITLE     CRYO-EM STRUCTURE OF A LATE HUMAN PRE-40S RIBOSOMAL SUBUNIT - STATE C 
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PRE-18S RIBOSOMAL RNA;                                     
COMPND   3 CHAIN: 2;                                                            
COMPND   4 MOL_ID: 2;                                                           
COMPND   5 MOLECULE: 40S RIBOSOMAL PROTEIN S5;                                  
COMPND   6 CHAIN: F;                                                            
COMPND   7 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US7;                        
COMPND   8 MOL_ID: 3;                                                           
COMPND   9 MOLECULE: 40S RIBOSOMAL PROTEIN S12;                                 
COMPND  10 CHAIN: M;                                                            
COMPND  11 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES12;                       
COMPND  12 MOL_ID: 4;                                                           
COMPND  13 MOLECULE: 40S RIBOSOMAL PROTEIN S15;                                 
COMPND  14 CHAIN: P;                                                            
COMPND  15 SYNONYM: RIG PROTEIN,SMALL RIBOSOMAL SUBUNIT PROTEIN US19;           
COMPND  16 MOL_ID: 5;                                                           
COMPND  17 MOLECULE: 40S RIBOSOMAL PROTEIN S16;                                 
COMPND  18 CHAIN: Q;                                                            
COMPND  19 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US9;                        
COMPND  20 MOL_ID: 6;                                                           
COMPND  21 MOLECULE: 40S RIBOSOMAL PROTEIN S17;                                 
COMPND  22 CHAIN: R;                                                            
COMPND  23 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES17;                       
COMPND  24 MOL_ID: 7;                                                           
COMPND  25 MOLECULE: 40S RIBOSOMAL PROTEIN S18;                                 
COMPND  26 CHAIN: S;                                                            
COMPND  27 SYNONYM: KE-3,KE3,SMALL RIBOSOMAL SUBUNIT PROTEIN US13;              
COMPND  28 MOL_ID: 8;                                                           
COMPND  29 MOLECULE: 40S RIBOSOMAL PROTEIN S19;                                 
COMPND  30 CHAIN: T;                                                            
COMPND  31 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES19;                       
COMPND  32 MOL_ID: 9;                                                           
COMPND  33 MOLECULE: 40S RIBOSOMAL PROTEIN S25;                                 
COMPND  34 CHAIN: Z;                                                            
COMPND  35 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES25;                       
COMPND  36 MOL_ID: 10;                                                          
COMPND  37 MOLECULE: 40S RIBOSOMAL PROTEIN S28;                                 
COMPND  38 CHAIN: c;                                                            
COMPND  39 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES28;                       
COMPND  40 MOL_ID: 11;                                                          
COMPND  41 MOLECULE: UBIQUITIN-40S RIBOSOMAL PROTEIN S27A;                      
COMPND  42 CHAIN: f;                                                            
COMPND  43 SYNONYM: UBIQUITIN CARBOXYL EXTENSION PROTEIN 80;                    
COMPND  44 MOL_ID: 12;                                                          
COMPND  45 MOLECULE: RECEPTOR OF ACTIVATED PROTEIN C KINASE 1;                  
COMPND  46 CHAIN: g;                                                            
COMPND  47 SYNONYM: CELL PROLIFERATION-INDUCING GENE 21 PROTEIN,GUANINE         
COMPND  48 NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2-LIKE 1,GUANINE NUCLEOTIDE- 
COMPND  49 BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 12.3,HUMAN LUNG CANCER     
COMPND  50 ONCOGENE 7 PROTEIN,HLC-7,RECEPTOR FOR ACTIVATED C KINASE,SMALL       
COMPND  51 RIBOSOMAL SUBUNIT PROTEIN RACK1;                                     
COMPND  52 MOL_ID: 13;                                                          
COMPND  53 MOLECULE: 40S RIBOSOMAL PROTEIN SA;                                  
COMPND  54 CHAIN: A;                                                            
COMPND  55 SYNONYM: 37 KDA LAMININ RECEPTOR PRECURSOR,37LRP,37/67 KDA LAMININ   
COMPND  56 RECEPTOR,LRP/LR,67 KDA LAMININ RECEPTOR,67LR,COLON CARCINOMA LAMININ-
COMPND  57 BINDING PROTEIN,LAMININ RECEPTOR 1,LAMR,LAMININ-BINDING PROTEIN      
COMPND  58 PRECURSOR P40,LBP/P40,MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN MGR1-  
COMPND  59 AG,NEM/1CHD4,SMALL RIBOSOMAL SUBUNIT PROTEIN US2;                    
COMPND  60 MOL_ID: 14;                                                          
COMPND  61 MOLECULE: 40S RIBOSOMAL PROTEIN S3A;                                 
COMPND  62 CHAIN: B;                                                            
COMPND  63 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES1,V-FOS TRANSFORMATION    
COMPND  64 EFFECTOR PROTEIN,FTE-1;                                              
COMPND  65 MOL_ID: 15;                                                          
COMPND  66 MOLECULE: 40S RIBOSOMAL PROTEIN S2;                                  
COMPND  67 CHAIN: C;                                                            
COMPND  68 SYNONYM: 40S RIBOSOMAL PROTEIN S4,PROTEIN LLREP3,SMALL RIBOSOMAL     
COMPND  69 SUBUNIT PROTEIN US5;                                                 
COMPND  70 MOL_ID: 16;                                                          
COMPND  71 MOLECULE: 40S RIBOSOMAL PROTEIN S4, X ISOFORM;                       
COMPND  72 CHAIN: E;                                                            
COMPND  73 SYNONYM: SCR10,SINGLE COPY ABUNDANT MRNA PROTEIN,SMALL RIBOSOMAL     
COMPND  74 SUBUNIT PROTEIN ES4;                                                 
COMPND  75 MOL_ID: 17;                                                          
COMPND  76 MOLECULE: 40S RIBOSOMAL PROTEIN S6;                                  
COMPND  77 CHAIN: G;                                                            
COMPND  78 SYNONYM: PHOSPHOPROTEIN NP33,SMALL RIBOSOMAL SUBUNIT PROTEIN ES6;    
COMPND  79 MOL_ID: 18;                                                          
COMPND  80 MOLECULE: 40S RIBOSOMAL PROTEIN S7;                                  
COMPND  81 CHAIN: H;                                                            
COMPND  82 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES7;                        
COMPND  83 MOL_ID: 19;                                                          
COMPND  84 MOLECULE: 40S RIBOSOMAL PROTEIN S8;                                  
COMPND  85 CHAIN: I;                                                            
COMPND  86 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES8;                        
COMPND  87 MOL_ID: 20;                                                          
COMPND  88 MOLECULE: 40S RIBOSOMAL PROTEIN S9;                                  
COMPND  89 CHAIN: J;                                                            
COMPND  90 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US4;                        
COMPND  91 MOL_ID: 21;                                                          
COMPND  92 MOLECULE: 40S RIBOSOMAL PROTEIN S11;                                 
COMPND  93 CHAIN: L;                                                            
COMPND  94 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US17;                       
COMPND  95 MOL_ID: 22;                                                          
COMPND  96 MOLECULE: 40S RIBOSOMAL PROTEIN S13;                                 
COMPND  97 CHAIN: N;                                                            
COMPND  98 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US15;                       
COMPND  99 MOL_ID: 23;                                                          
COMPND 100 MOLECULE: 40S RIBOSOMAL PROTEIN S14;                                 
COMPND 101 CHAIN: O;                                                            
COMPND 102 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US11;                       
COMPND 103 MOL_ID: 24;                                                          
COMPND 104 MOLECULE: 40S RIBOSOMAL PROTEIN S21;                                 
COMPND 105 CHAIN: V;                                                            
COMPND 106 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES21;                       
COMPND 107 MOL_ID: 25;                                                          
COMPND 108 MOLECULE: 40S RIBOSOMAL PROTEIN S15A;                                
COMPND 109 CHAIN: W;                                                            
COMPND 110 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US8;                        
COMPND 111 MOL_ID: 26;                                                          
COMPND 112 MOLECULE: 40S RIBOSOMAL PROTEIN S23;                                 
COMPND 113 CHAIN: X;                                                            
COMPND 114 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US12;                       
COMPND 115 MOL_ID: 27;                                                          
COMPND 116 MOLECULE: 40S RIBOSOMAL PROTEIN S24;                                 
COMPND 117 CHAIN: Y;                                                            
COMPND 118 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES24;                       
COMPND 119 MOL_ID: 28;                                                          
COMPND 120 MOLECULE: 40S RIBOSOMAL PROTEIN S27;                                 
COMPND 121 CHAIN: b;                                                            
COMPND 122 SYNONYM: METALLOPAN-STIMULIN 1,MPS-1,SMALL RIBOSOMAL SUBUNIT PROTEIN 
COMPND 123 ES27;                                                                
COMPND 124 MOL_ID: 29;                                                          
COMPND 125 MOLECULE: 40S RIBOSOMAL PROTEIN S30;                                 
COMPND 126 CHAIN: e;                                                            
COMPND 127 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES30;                       
COMPND 128 MOL_ID: 30;                                                          
COMPND 129 MOLECULE: RNA-BINDING PROTEIN PNO1;                                  
COMPND 130 CHAIN: x;                                                            
COMPND 131 MOL_ID: 31;                                                          
COMPND 132 MOLECULE: RNA-BINDING PROTEIN NOB1;                                  
COMPND 133 CHAIN: y;                                                            
COMPND 134 SYNONYM: PHOSPHORYLATION REGULATORY PROTEIN HP-10,PROTEIN ART-4;     
COMPND 135 MOL_ID: 32;                                                          
COMPND 136 MOLECULE: PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG;                  
COMPND 137 CHAIN: u;                                                            
COMPND 138 MOL_ID: 33;                                                          
COMPND 139 MOLECULE: BYSTIN;                                                    
COMPND 140 CHAIN: w;                                                            
COMPND 141 MOL_ID: 34;                                                          
COMPND 142 MOLECULE: SERINE/THREONINE-PROTEIN KINASE RIO2;                      
COMPND 143 CHAIN: v;                                                            
COMPND 144 SYNONYM: RIO KINASE 2;                                               
COMPND 145 EC: 2.7.11.1;                                                        
COMPND 146 MOL_ID: 35;                                                          
COMPND 147 MOLECULE: PROTEIN LTV1 HOMOLOG;                                      
COMPND 148 CHAIN: t                                                             
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_TAXID: 9606;                                                
SOURCE   4 MOL_ID: 2;                                                           
SOURCE   5 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   6 ORGANISM_COMMON: HUMAN;                                              
SOURCE   7 ORGANISM_TAXID: 9606;                                                
SOURCE   8 MOL_ID: 3;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 MOL_ID: 4;                                                           
SOURCE  13 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  14 ORGANISM_COMMON: HUMAN;                                              
SOURCE  15 ORGANISM_TAXID: 9606;                                                
SOURCE  16 MOL_ID: 5;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  18 ORGANISM_COMMON: HUMAN;                                              
SOURCE  19 ORGANISM_TAXID: 9606;                                                
SOURCE  20 MOL_ID: 6;                                                           
SOURCE  21 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  22 ORGANISM_COMMON: HUMAN;                                              
SOURCE  23 ORGANISM_TAXID: 9606;                                                
SOURCE  24 MOL_ID: 7;                                                           
SOURCE  25 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  26 ORGANISM_COMMON: HUMAN;                                              
SOURCE  27 ORGANISM_TAXID: 9606;                                                
SOURCE  28 MOL_ID: 8;                                                           
SOURCE  29 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  30 ORGANISM_COMMON: HUMAN;                                              
SOURCE  31 ORGANISM_TAXID: 9606;                                                
SOURCE  32 MOL_ID: 9;                                                           
SOURCE  33 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  34 ORGANISM_COMMON: HUMAN;                                              
SOURCE  35 ORGANISM_TAXID: 9606;                                                
SOURCE  36 MOL_ID: 10;                                                          
SOURCE  37 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  38 ORGANISM_COMMON: HUMAN;                                              
SOURCE  39 ORGANISM_TAXID: 9606;                                                
SOURCE  40 MOL_ID: 11;                                                          
SOURCE  41 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  42 ORGANISM_COMMON: HUMAN;                                              
SOURCE  43 ORGANISM_TAXID: 9606;                                                
SOURCE  44 MOL_ID: 12;                                                          
SOURCE  45 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  46 ORGANISM_COMMON: HUMAN;                                              
SOURCE  47 ORGANISM_TAXID: 9606;                                                
SOURCE  48 MOL_ID: 13;                                                          
SOURCE  49 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  50 ORGANISM_COMMON: HUMAN;                                              
SOURCE  51 ORGANISM_TAXID: 9606;                                                
SOURCE  52 MOL_ID: 14;                                                          
SOURCE  53 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  54 ORGANISM_COMMON: HUMAN;                                              
SOURCE  55 ORGANISM_TAXID: 9606;                                                
SOURCE  56 MOL_ID: 15;                                                          
SOURCE  57 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  58 ORGANISM_COMMON: HUMAN;                                              
SOURCE  59 ORGANISM_TAXID: 9606;                                                
SOURCE  60 MOL_ID: 16;                                                          
SOURCE  61 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  62 ORGANISM_COMMON: HUMAN;                                              
SOURCE  63 ORGANISM_TAXID: 9606;                                                
SOURCE  64 MOL_ID: 17;                                                          
SOURCE  65 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  66 ORGANISM_COMMON: HUMAN;                                              
SOURCE  67 ORGANISM_TAXID: 9606;                                                
SOURCE  68 MOL_ID: 18;                                                          
SOURCE  69 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  70 ORGANISM_COMMON: HUMAN;                                              
SOURCE  71 ORGANISM_TAXID: 9606;                                                
SOURCE  72 MOL_ID: 19;                                                          
SOURCE  73 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  74 ORGANISM_COMMON: HUMAN;                                              
SOURCE  75 ORGANISM_TAXID: 9606;                                                
SOURCE  76 MOL_ID: 20;                                                          
SOURCE  77 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  78 ORGANISM_COMMON: HUMAN;                                              
SOURCE  79 ORGANISM_TAXID: 9606;                                                
SOURCE  80 MOL_ID: 21;                                                          
SOURCE  81 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  82 ORGANISM_COMMON: HUMAN;                                              
SOURCE  83 ORGANISM_TAXID: 9606;                                                
SOURCE  84 MOL_ID: 22;                                                          
SOURCE  85 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  86 ORGANISM_COMMON: HUMAN;                                              
SOURCE  87 ORGANISM_TAXID: 9606;                                                
SOURCE  88 MOL_ID: 23;                                                          
SOURCE  89 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  90 ORGANISM_COMMON: HUMAN;                                              
SOURCE  91 ORGANISM_TAXID: 9606;                                                
SOURCE  92 MOL_ID: 24;                                                          
SOURCE  93 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  94 ORGANISM_COMMON: HUMAN;                                              
SOURCE  95 ORGANISM_TAXID: 9606;                                                
SOURCE  96 MOL_ID: 25;                                                          
SOURCE  97 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  98 ORGANISM_COMMON: HUMAN;                                              
SOURCE  99 ORGANISM_TAXID: 9606;                                                
SOURCE 100 MOL_ID: 26;                                                          
SOURCE 101 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 102 ORGANISM_COMMON: HUMAN;                                              
SOURCE 103 ORGANISM_TAXID: 9606;                                                
SOURCE 104 MOL_ID: 27;                                                          
SOURCE 105 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 106 ORGANISM_COMMON: HUMAN;                                              
SOURCE 107 ORGANISM_TAXID: 9606;                                                
SOURCE 108 MOL_ID: 28;                                                          
SOURCE 109 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 110 ORGANISM_COMMON: HUMAN;                                              
SOURCE 111 ORGANISM_TAXID: 9606;                                                
SOURCE 112 MOL_ID: 29;                                                          
SOURCE 113 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 114 ORGANISM_COMMON: HUMAN;                                              
SOURCE 115 ORGANISM_TAXID: 9606;                                                
SOURCE 116 MOL_ID: 30;                                                          
SOURCE 117 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 118 ORGANISM_COMMON: HUMAN;                                              
SOURCE 119 ORGANISM_TAXID: 9606;                                                
SOURCE 120 MOL_ID: 31;                                                          
SOURCE 121 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 122 ORGANISM_COMMON: HUMAN;                                              
SOURCE 123 ORGANISM_TAXID: 9606;                                                
SOURCE 124 MOL_ID: 32;                                                          
SOURCE 125 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 126 ORGANISM_COMMON: HUMAN;                                              
SOURCE 127 ORGANISM_TAXID: 9606;                                                
SOURCE 128 MOL_ID: 33;                                                          
SOURCE 129 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 130 ORGANISM_COMMON: HUMAN;                                              
SOURCE 131 ORGANISM_TAXID: 9606;                                                
SOURCE 132 MOL_ID: 34;                                                          
SOURCE 133 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 134 ORGANISM_COMMON: HUMAN;                                              
SOURCE 135 ORGANISM_TAXID: 9606;                                                
SOURCE 136 MOL_ID: 35;                                                          
SOURCE 137 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 138 ORGANISM_COMMON: HUMAN;                                              
SOURCE 139 ORGANISM_TAXID: 9606                                                 
KEYWDS    40S, PRE-40S, RIBOSOME BIOGENESIS, RIBOSOME                           
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    M.AMEISMEIER,J.CHENG,O.BERNINGHAUSEN,R.BECKMANN                       
REVDAT   6   11-DEC-19 6G18    1       CRYST1 SCALE                             
REVDAT   5   30-OCT-19 6G18    1       REMARK LINK                              
REVDAT   4   17-OCT-18 6G18    1       REMARK                                   
REVDAT   3   27-JUN-18 6G18    1       JRNL                                     
REVDAT   2   20-JUN-18 6G18    1       JRNL                                     
REVDAT   1   06-JUN-18 6G18    0                                                
JRNL        AUTH   M.AMEISMEIER,J.CHENG,O.BERNINGHAUSEN,R.BECKMANN              
JRNL        TITL   VISUALIZING LATE STATES OF HUMAN 40S RIBOSOMAL SUBUNIT       
JRNL        TITL 2 MATURATION.                                                  
JRNL        REF    NATURE                        V. 558   249 2018              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   29875412                                                     
JRNL        DOI    10.1038/S41586-018-0193-0                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.600                          
REMARK   3   NUMBER OF PARTICLES               : 287847                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6G18 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 20-MAR-18.                  
REMARK 100 THE DEPOSITION ID IS D_1200009160.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : CRYO-EM STRUCTURE OF A HUMAN      
REMARK 245                                    PRE-40S RIBOSOMAL SUBUNIT WITH    
REMARK 245                                    BOUND PNO1, NOB1, TSR1, BYST,     
REMARK 245                                    RIOK2 AND LTV1                    
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.60                              
REMARK 245   SAMPLE DETAILS                 : CYTOPLASMIC PRECURSOR OF THE      
REMARK 245  HUMAN SMALL RIBOSOMAL SUBUNIT (PRE-40S) PURIFIED BY AFFINITY        
REMARK 245  CHROMATOGRAPHY USING THE STFLAG-TAGGED RIBOSOMAL BIOGENESIS         
REMARK 245  FACTOR PNO1                                                         
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : FEI FALCON II (4K X 4K)        
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 2.50                           
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 35-MERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 35-MERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 208420 ANGSTROM**2                        
REMARK 350 SURFACE AREA OF THE COMPLEX: 449000 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -1516.0 KCAL/MOL                      
REMARK 350 APPLY THE FOLLOWING TO CHAINS: 2, F, M, P, Q, R, S, T, Z, c,         
REMARK 350                    AND CHAINS: f, g, A, B, C, E, G, H, I,            
REMARK 350                    AND CHAINS: J, L, N, O, V, W, X, Y, b, e,         
REMARK 350                    AND CHAINS: x, y, u, w, v, t                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465       C 2   131                                                      
REMARK 465       U 2   132                                                      
REMARK 465       C 2   133                                                      
REMARK 465       C 2   134                                                      
REMARK 465       U 2   135                                                      
REMARK 465       C 2   136                                                      
REMARK 465       U 2   137                                                      
REMARK 465       C 2   138                                                      
REMARK 465       C 2   139                                                      
REMARK 465       A 2   226                                                      
REMARK 465       U 2   227                                                      
REMARK 465       C 2   228                                                      
REMARK 465       A 2   229                                                      
REMARK 465       A 2   230                                                      
REMARK 465       A 2   231                                                      
REMARK 465       A 2   232                                                      
REMARK 465       C 2   233                                                      
REMARK 465       C 2   234                                                      
REMARK 465       A 2   235                                                      
REMARK 465       A 2   236                                                      
REMARK 465       C 2   237                                                      
REMARK 465       C 2   238                                                      
REMARK 465       C 2   239                                                      
REMARK 465       G 2   240                                                      
REMARK 465       G 2   241                                                      
REMARK 465       U 2   242                                                      
REMARK 465       C 2   243                                                      
REMARK 465       A 2   244                                                      
REMARK 465       G 2   245                                                      
REMARK 465       C 2   246                                                      
REMARK 465       C 2   247                                                      
REMARK 465       C 2   248                                                      
REMARK 465       C 2   249                                                      
REMARK 465       U 2   250                                                      
REMARK 465       C 2   251                                                      
REMARK 465       U 2   252                                                      
REMARK 465       C 2   253                                                      
REMARK 465       C 2   254                                                      
REMARK 465       G 2   255                                                      
REMARK 465       G 2   256                                                      
REMARK 465       C 2   257                                                      
REMARK 465       C 2   258                                                      
REMARK 465       C 2   259                                                      
REMARK 465       C 2   260                                                      
REMARK 465       G 2   261                                                      
REMARK 465       G 2   262                                                      
REMARK 465       C 2   263                                                      
REMARK 465       C 2   264                                                      
REMARK 465       G 2   265                                                      
REMARK 465       G 2   266                                                      
REMARK 465       G 2   267                                                      
REMARK 465       G 2   268                                                      
REMARK 465       G 2   269                                                      
REMARK 465       G 2   270                                                      
REMARK 465       C 2   271                                                      
REMARK 465       G 2   272                                                      
REMARK 465       G 2   273                                                      
REMARK 465       G 2   274                                                      
REMARK 465       C 2   275                                                      
REMARK 465       G 2   276                                                      
REMARK 465       C 2   277                                                      
REMARK 465       C 2   278                                                      
REMARK 465       G 2   279                                                      
REMARK 465       G 2   280                                                      
REMARK 465       C 2   281                                                      
REMARK 465       G 2   282                                                      
REMARK 465       G 2   283                                                      
REMARK 465       C 2   284                                                      
REMARK 465       U 2   285                                                      
REMARK 465       U 2   286                                                      
REMARK 465       C 2   323                                                      
REMARK 465       C 2   324                                                      
REMARK 465       C 2   325                                                      
REMARK 465       C 2   326                                                      
REMARK 465       G 2   327                                                      
REMARK 465       U 2   328                                                      
REMARK 465       U 2   689                                                      
REMARK 465       G 2   690                                                      
REMARK 465       G 2   691                                                      
REMARK 465       G 2   692                                                      
REMARK 465       A 2   693                                                      
REMARK 465       G 2   694                                                      
REMARK 465       C 2   695                                                      
REMARK 465       G 2   696                                                      
REMARK 465       G 2   697                                                      
REMARK 465       G 2   698                                                      
REMARK 465       C 2   699                                                      
REMARK 465       G 2   700                                                      
REMARK 465       G 2   701                                                      
REMARK 465       G 2   702                                                      
REMARK 465       C 2   703                                                      
REMARK 465       G 2   704                                                      
REMARK 465       G 2   705                                                      
REMARK 465       U 2   706                                                      
REMARK 465       C 2   707                                                      
REMARK 465       C 2   708                                                      
REMARK 465       G 2   709                                                      
REMARK 465       C 2   710                                                      
REMARK 465       C 2   711                                                      
REMARK 465       G 2   712                                                      
REMARK 465       C 2   713                                                      
REMARK 465       G 2   714                                                      
REMARK 465       A 2   715                                                      
REMARK 465       G 2   716                                                      
REMARK 465       G 2   717                                                      
REMARK 465       C 2   718                                                      
REMARK 465       G 2   719                                                      
REMARK 465       A 2   720                                                      
REMARK 465       G 2   721                                                      
REMARK 465       C 2   722                                                      
REMARK 465       C 2   723                                                      
REMARK 465       A 2   724                                                      
REMARK 465       C 2   725                                                      
REMARK 465       C 2   726                                                      
REMARK 465       G 2   727                                                      
REMARK 465       C 2   728                                                      
REMARK 465       C 2   729                                                      
REMARK 465       C 2   730                                                      
REMARK 465       G 2   731                                                      
REMARK 465       U 2   732                                                      
REMARK 465       C 2   733                                                      
REMARK 465       C 2   734                                                      
REMARK 465       C 2   735                                                      
REMARK 465       C 2   736                                                      
REMARK 465       G 2   737                                                      
REMARK 465       C 2   738                                                      
REMARK 465       C 2   739                                                      
REMARK 465       C 2   740                                                      
REMARK 465       C 2   741                                                      
REMARK 465       U 2   742                                                      
REMARK 465       U 2   743                                                      
REMARK 465       G 2   744                                                      
REMARK 465       C 2   745                                                      
REMARK 465       C 2   753                                                      
REMARK 465       G 2   754                                                      
REMARK 465       C 2   755                                                      
REMARK 465       C 2   756                                                      
REMARK 465       C 2   757                                                      
REMARK 465       C 2   758                                                      
REMARK 465       C 2   759                                                      
REMARK 465       U 2   760                                                      
REMARK 465       C 2   761                                                      
REMARK 465       G 2   762                                                      
REMARK 465       A 2   763                                                      
REMARK 465       U 2   764                                                      
REMARK 465       G 2   765                                                      
REMARK 465       C 2   766                                                      
REMARK 465       U 2   767                                                      
REMARK 465       C 2   768                                                      
REMARK 465       U 2   769                                                      
REMARK 465       U 2   770                                                      
REMARK 465       A 2   771                                                      
REMARK 465       G 2   772                                                      
REMARK 465       C 2   773                                                      
REMARK 465       U 2   774                                                      
REMARK 465       G 2   775                                                      
REMARK 465       A 2   776                                                      
REMARK 465       G 2   777                                                      
REMARK 465       U 2   778                                                      
REMARK 465       G 2   779                                                      
REMARK 465       U 2   780                                                      
REMARK 465       C 2   781                                                      
REMARK 465       C 2   782                                                      
REMARK 465       C 2   783                                                      
REMARK 465       G 2   784                                                      
REMARK 465       C 2   785                                                      
REMARK 465       G 2   786                                                      
REMARK 465       G 2   787                                                      
REMARK 465       G 2   788                                                      
REMARK 465       G 2   789                                                      
REMARK 465       C 2   790                                                      
REMARK 465       C 2   835                                                      
REMARK 465       G 2   836                                                      
REMARK 465       A 2   837                                                      
REMARK 465       G 2   838                                                      
REMARK 465       C 2   839                                                      
REMARK 465       C 2   840                                                      
REMARK 465       U 2  1343                                                      
REMARK 465       C 2  1417                                                      
REMARK 465       C 2  1418                                                      
REMARK 465       C 2  1419                                                      
REMARK 465       G 2  1420                                                      
REMARK 465       A 2  1421                                                      
REMARK 465       G 2  1422                                                      
REMARK 465       C 2  1423                                                      
REMARK 465       C 2  1433                                                      
REMARK 465       C 2  1434                                                      
REMARK 465       C 2  1435                                                      
REMARK 465       C 2  1436                                                      
REMARK 465       C 2  1437                                                      
REMARK 465       G 2  1552                                                      
REMARK 465       C 2  1553                                                      
REMARK 465       C 2  1554                                                      
REMARK 465       U 2  1555                                                      
REMARK 465       A 2  1556                                                      
REMARK 465       C 2  1557                                                      
REMARK 465       C 2  1696                                                      
REMARK 465       A 2  1697                                                      
REMARK 465       C 2  1703                                                      
REMARK 465       C 2  1704                                                      
REMARK 465       C 2  1762                                                      
REMARK 465       G 2  1763                                                      
REMARK 465       G 2  1764                                                      
REMARK 465       C 2  1765                                                      
REMARK 465       C 2  1766                                                      
REMARK 465       C 2  1767                                                      
REMARK 465       A 2  1768                                                      
REMARK 465       C 2  1769                                                      
REMARK 465       G 2  1770                                                      
REMARK 465       U 2  1830                                                      
REMARK 465       A 2  1831                                                      
REMARK 465       A 2  1832                                                      
REMARK 465       C 2  1833                                                      
REMARK 465       A 2  1834                                                      
REMARK 465       A 2  1835                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     GLU F     3                                                      
REMARK 465     TRP F     4                                                      
REMARK 465     GLU F     5                                                      
REMARK 465     THR F     6                                                      
REMARK 465     ALA F     7                                                      
REMARK 465     ALA F     8                                                      
REMARK 465     PRO F     9                                                      
REMARK 465     ALA F    10                                                      
REMARK 465     VAL F    11                                                      
REMARK 465     ALA F    12                                                      
REMARK 465     GLU F    13                                                      
REMARK 465     THR F    14                                                      
REMARK 465     PRO F    15                                                      
REMARK 465     MET M     1                                                      
REMARK 465     ALA M     2                                                      
REMARK 465     GLU M     3                                                      
REMARK 465     GLU M     4                                                      
REMARK 465     GLY M     5                                                      
REMARK 465     ILE M     6                                                      
REMARK 465     ALA M     7                                                      
REMARK 465     ALA M     8                                                      
REMARK 465     GLY M     9                                                      
REMARK 465     MET P     1                                                      
REMARK 465     ALA P     2                                                      
REMARK 465     GLU P     3                                                      
REMARK 465     VAL P     4                                                      
REMARK 465     GLU P     5                                                      
REMARK 465     GLN P     6                                                      
REMARK 465     LYS P     7                                                      
REMARK 465     LYS P     8                                                      
REMARK 465     LYS P     9                                                      
REMARK 465     ARG P    10                                                      
REMARK 465     THR P    11                                                      
REMARK 465     PHE P    12                                                      
REMARK 465     ARG P    13                                                      
REMARK 465     LYS P    14                                                      
REMARK 465     ALA P   135                                                      
REMARK 465     THR P   136                                                      
REMARK 465     HIS P   137                                                      
REMARK 465     SER P   138                                                      
REMARK 465     SER P   139                                                      
REMARK 465     ARG P   140                                                      
REMARK 465     PHE P   141                                                      
REMARK 465     ILE P   142                                                      
REMARK 465     PRO P   143                                                      
REMARK 465     LEU P   144                                                      
REMARK 465     LYS P   145                                                      
REMARK 465     MET Q     1                                                      
REMARK 465     PRO Q     2                                                      
REMARK 465     SER Q     3                                                      
REMARK 465     LYS Q     4                                                      
REMARK 465     GLY Q     5                                                      
REMARK 465     PRO Q     6                                                      
REMARK 465     LEU Q     7                                                      
REMARK 465     LYS Q   130                                                      
REMARK 465     LYS Q   131                                                      
REMARK 465     PHE Q   132                                                      
REMARK 465     GLY Q   133                                                      
REMARK 465     GLY Q   134                                                      
REMARK 465     PRO Q   135                                                      
REMARK 465     GLY Q   136                                                      
REMARK 465     ALA Q   137                                                      
REMARK 465     ARG Q   138                                                      
REMARK 465     ALA Q   139                                                      
REMARK 465     ARG Q   140                                                      
REMARK 465     TYR Q   141                                                      
REMARK 465     GLN Q   142                                                      
REMARK 465     LYS Q   143                                                      
REMARK 465     SER Q   144                                                      
REMARK 465     TYR Q   145                                                      
REMARK 465     ARG Q   146                                                      
REMARK 465     MET R     1                                                      
REMARK 465     VAL R   124                                                      
REMARK 465     GLY R   125                                                      
REMARK 465     MET R   126                                                      
REMARK 465     ASN R   127                                                      
REMARK 465     PHE R   128                                                      
REMARK 465     LYS R   129                                                      
REMARK 465     THR R   130                                                      
REMARK 465     PRO R   131                                                      
REMARK 465     ARG R   132                                                      
REMARK 465     GLY R   133                                                      
REMARK 465     PRO R   134                                                      
REMARK 465     VAL R   135                                                      
REMARK 465     MET S     1                                                      
REMARK 465     SER S     2                                                      
REMARK 465     GLY S   133                                                      
REMARK 465     GLN S   134                                                      
REMARK 465     HIS S   135                                                      
REMARK 465     THR S   136                                                      
REMARK 465     LYS S   137                                                      
REMARK 465     THR S   138                                                      
REMARK 465     THR S   139                                                      
REMARK 465     GLY S   140                                                      
REMARK 465     ARG S   141                                                      
REMARK 465     ARG S   142                                                      
REMARK 465     GLY S   143                                                      
REMARK 465     ARG S   144                                                      
REMARK 465     THR S   145                                                      
REMARK 465     VAL S   146                                                      
REMARK 465     GLY S   147                                                      
REMARK 465     VAL S   148                                                      
REMARK 465     SER S   149                                                      
REMARK 465     LYS S   150                                                      
REMARK 465     LYS S   151                                                      
REMARK 465     LYS S   152                                                      
REMARK 465     MET T     1                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     PRO Z     2                                                      
REMARK 465     PRO Z     3                                                      
REMARK 465     LYS Z     4                                                      
REMARK 465     ASP Z     5                                                      
REMARK 465     ASP Z     6                                                      
REMARK 465     LYS Z     7                                                      
REMARK 465     LYS Z     8                                                      
REMARK 465     LYS Z     9                                                      
REMARK 465     LYS Z    10                                                      
REMARK 465     ASP Z    11                                                      
REMARK 465     ALA Z    12                                                      
REMARK 465     GLY Z    13                                                      
REMARK 465     LYS Z    14                                                      
REMARK 465     SER Z    15                                                      
REMARK 465     ALA Z    16                                                      
REMARK 465     LYS Z    17                                                      
REMARK 465     LYS Z    18                                                      
REMARK 465     ASP Z    19                                                      
REMARK 465     LYS Z    20                                                      
REMARK 465     ASP Z    21                                                      
REMARK 465     PRO Z    22                                                      
REMARK 465     VAL Z    23                                                      
REMARK 465     ASN Z    24                                                      
REMARK 465     LYS Z    25                                                      
REMARK 465     SER Z    26                                                      
REMARK 465     GLY Z    27                                                      
REMARK 465     GLY Z    28                                                      
REMARK 465     LYS Z    29                                                      
REMARK 465     ALA Z    30                                                      
REMARK 465     LYS Z    31                                                      
REMARK 465     LYS Z    32                                                      
REMARK 465     LYS Z    33                                                      
REMARK 465     LYS Z    34                                                      
REMARK 465     TRP Z    35                                                      
REMARK 465     SER Z    36                                                      
REMARK 465     LYS Z    37                                                      
REMARK 465     GLY Z    38                                                      
REMARK 465     LYS Z    39                                                      
REMARK 465     VAL Z    40                                                      
REMARK 465     ARG Z    41                                                      
REMARK 465     LYS Z   114                                                      
REMARK 465     GLY Z   115                                                      
REMARK 465     GLY Z   116                                                      
REMARK 465     ASP Z   117                                                      
REMARK 465     ALA Z   118                                                      
REMARK 465     PRO Z   119                                                      
REMARK 465     ALA Z   120                                                      
REMARK 465     ALA Z   121                                                      
REMARK 465     GLY Z   122                                                      
REMARK 465     GLU Z   123                                                      
REMARK 465     ASP Z   124                                                      
REMARK 465     ALA Z   125                                                      
REMARK 465     MET c     1                                                      
REMARK 465     ASP c     2                                                      
REMARK 465     THR c     3                                                      
REMARK 465     SER c     4                                                      
REMARK 465     ARG c     5                                                      
REMARK 465     VAL c     6                                                      
REMARK 465     GLN c     7                                                      
REMARK 465     ARG c    69                                                      
REMARK 465     MET f     1                                                      
REMARK 465     GLN f     2                                                      
REMARK 465     ILE f     3                                                      
REMARK 465     PHE f     4                                                      
REMARK 465     VAL f     5                                                      
REMARK 465     LYS f     6                                                      
REMARK 465     THR f     7                                                      
REMARK 465     LEU f     8                                                      
REMARK 465     THR f     9                                                      
REMARK 465     GLY f    10                                                      
REMARK 465     LYS f    11                                                      
REMARK 465     THR f    12                                                      
REMARK 465     ILE f    13                                                      
REMARK 465     THR f    14                                                      
REMARK 465     LEU f    15                                                      
REMARK 465     GLU f    16                                                      
REMARK 465     VAL f    17                                                      
REMARK 465     GLU f    18                                                      
REMARK 465     PRO f    19                                                      
REMARK 465     SER f    20                                                      
REMARK 465     ASP f    21                                                      
REMARK 465     THR f    22                                                      
REMARK 465     ILE f    23                                                      
REMARK 465     GLU f    24                                                      
REMARK 465     ASN f    25                                                      
REMARK 465     VAL f    26                                                      
REMARK 465     LYS f    27                                                      
REMARK 465     ALA f    28                                                      
REMARK 465     LYS f    29                                                      
REMARK 465     ILE f    30                                                      
REMARK 465     GLN f    31                                                      
REMARK 465     ASP f    32                                                      
REMARK 465     LYS f    33                                                      
REMARK 465     GLU f    34                                                      
REMARK 465     GLY f    35                                                      
REMARK 465     ILE f    36                                                      
REMARK 465     PRO f    37                                                      
REMARK 465     PRO f    38                                                      
REMARK 465     ASP f    39                                                      
REMARK 465     GLN f    40                                                      
REMARK 465     GLN f    41                                                      
REMARK 465     ARG f    42                                                      
REMARK 465     LEU f    43                                                      
REMARK 465     ILE f    44                                                      
REMARK 465     PHE f    45                                                      
REMARK 465     ALA f    46                                                      
REMARK 465     GLY f    47                                                      
REMARK 465     LYS f    48                                                      
REMARK 465     GLN f    49                                                      
REMARK 465     LEU f    50                                                      
REMARK 465     GLU f    51                                                      
REMARK 465     ASP f    52                                                      
REMARK 465     GLY f    53                                                      
REMARK 465     ARG f    54                                                      
REMARK 465     THR f    55                                                      
REMARK 465     LEU f    56                                                      
REMARK 465     SER f    57                                                      
REMARK 465     ASP f    58                                                      
REMARK 465     TYR f    59                                                      
REMARK 465     ASN f    60                                                      
REMARK 465     ILE f    61                                                      
REMARK 465     GLN f    62                                                      
REMARK 465     LYS f    63                                                      
REMARK 465     GLU f    64                                                      
REMARK 465     SER f    65                                                      
REMARK 465     THR f    66                                                      
REMARK 465     LEU f    67                                                      
REMARK 465     HIS f    68                                                      
REMARK 465     LEU f    69                                                      
REMARK 465     VAL f    70                                                      
REMARK 465     LEU f    71                                                      
REMARK 465     ARG f    72                                                      
REMARK 465     LEU f    73                                                      
REMARK 465     ARG f    74                                                      
REMARK 465     GLY f    75                                                      
REMARK 465     GLY f    76                                                      
REMARK 465     PHE f   150                                                      
REMARK 465     ASN f   151                                                      
REMARK 465     LYS f   152                                                      
REMARK 465     PRO f   153                                                      
REMARK 465     GLU f   154                                                      
REMARK 465     ASP f   155                                                      
REMARK 465     LYS f   156                                                      
REMARK 465     MET g     1                                                      
REMARK 465     THR g     2                                                      
REMARK 465     THR g   316                                                      
REMARK 465     ARG g   317                                                      
REMARK 465     MET A     1                                                      
REMARK 465     ALA A   218                                                      
REMARK 465     GLU A   219                                                      
REMARK 465     LYS A   220                                                      
REMARK 465     ALA A   221                                                      
REMARK 465     VAL A   222                                                      
REMARK 465     THR A   223                                                      
REMARK 465     LYS A   224                                                      
REMARK 465     GLU A   225                                                      
REMARK 465     GLU A   226                                                      
REMARK 465     PHE A   227                                                      
REMARK 465     GLN A   228                                                      
REMARK 465     GLY A   229                                                      
REMARK 465     GLU A   230                                                      
REMARK 465     TRP A   231                                                      
REMARK 465     THR A   232                                                      
REMARK 465     ALA A   233                                                      
REMARK 465     PRO A   234                                                      
REMARK 465     ALA A   235                                                      
REMARK 465     PRO A   236                                                      
REMARK 465     GLU A   237                                                      
REMARK 465     PHE A   238                                                      
REMARK 465     THR A   239                                                      
REMARK 465     ALA A   240                                                      
REMARK 465     THR A   241                                                      
REMARK 465     GLN A   242                                                      
REMARK 465     PRO A   243                                                      
REMARK 465     GLU A   244                                                      
REMARK 465     VAL A   245                                                      
REMARK 465     ALA A   246                                                      
REMARK 465     ASP A   247                                                      
REMARK 465     TRP A   248                                                      
REMARK 465     SER A   249                                                      
REMARK 465     GLU A   250                                                      
REMARK 465     GLY A   251                                                      
REMARK 465     VAL A   252                                                      
REMARK 465     GLN A   253                                                      
REMARK 465     VAL A   254                                                      
REMARK 465     PRO A   255                                                      
REMARK 465     SER A   256                                                      
REMARK 465     VAL A   257                                                      
REMARK 465     PRO A   258                                                      
REMARK 465     ILE A   259                                                      
REMARK 465     GLN A   260                                                      
REMARK 465     GLN A   261                                                      
REMARK 465     PHE A   262                                                      
REMARK 465     PRO A   263                                                      
REMARK 465     THR A   264                                                      
REMARK 465     GLU A   265                                                      
REMARK 465     ASP A   266                                                      
REMARK 465     TRP A   267                                                      
REMARK 465     SER A   268                                                      
REMARK 465     ALA A   269                                                      
REMARK 465     GLN A   270                                                      
REMARK 465     PRO A   271                                                      
REMARK 465     ALA A   272                                                      
REMARK 465     THR A   273                                                      
REMARK 465     GLU A   274                                                      
REMARK 465     ASP A   275                                                      
REMARK 465     TRP A   276                                                      
REMARK 465     SER A   277                                                      
REMARK 465     ALA A   278                                                      
REMARK 465     ALA A   279                                                      
REMARK 465     PRO A   280                                                      
REMARK 465     THR A   281                                                      
REMARK 465     ALA A   282                                                      
REMARK 465     GLN A   283                                                      
REMARK 465     ALA A   284                                                      
REMARK 465     THR A   285                                                      
REMARK 465     GLU A   286                                                      
REMARK 465     TRP A   287                                                      
REMARK 465     VAL A   288                                                      
REMARK 465     GLY A   289                                                      
REMARK 465     ALA A   290                                                      
REMARK 465     THR A   291                                                      
REMARK 465     THR A   292                                                      
REMARK 465     ASP A   293                                                      
REMARK 465     TRP A   294                                                      
REMARK 465     SER A   295                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     VAL B     3                                                      
REMARK 465     GLY B     4                                                      
REMARK 465     LYS B     5                                                      
REMARK 465     ASN B     6                                                      
REMARK 465     LYS B     7                                                      
REMARK 465     ARG B     8                                                      
REMARK 465     LEU B     9                                                      
REMARK 465     THR B    10                                                      
REMARK 465     LYS B    11                                                      
REMARK 465     GLY B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     LYS B    14                                                      
REMARK 465     LYS B    15                                                      
REMARK 465     GLY B    16                                                      
REMARK 465     ALA B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     LYS B    19                                                      
REMARK 465     LYS B    20                                                      
REMARK 465     GLU B   234                                                      
REMARK 465     GLY B   235                                                      
REMARK 465     SER B   236                                                      
REMARK 465     SER B   237                                                      
REMARK 465     SER B   238                                                      
REMARK 465     GLY B   239                                                      
REMARK 465     LYS B   240                                                      
REMARK 465     ALA B   241                                                      
REMARK 465     THR B   242                                                      
REMARK 465     GLY B   243                                                      
REMARK 465     ASP B   244                                                      
REMARK 465     GLU B   245                                                      
REMARK 465     THR B   246                                                      
REMARK 465     GLY B   247                                                      
REMARK 465     ALA B   248                                                      
REMARK 465     LYS B   249                                                      
REMARK 465     VAL B   250                                                      
REMARK 465     GLU B   251                                                      
REMARK 465     ARG B   252                                                      
REMARK 465     ALA B   253                                                      
REMARK 465     ASP B   254                                                      
REMARK 465     GLY B   255                                                      
REMARK 465     TYR B   256                                                      
REMARK 465     GLU B   257                                                      
REMARK 465     PRO B   258                                                      
REMARK 465     PRO B   259                                                      
REMARK 465     VAL B   260                                                      
REMARK 465     GLN B   261                                                      
REMARK 465     GLU B   262                                                      
REMARK 465     SER B   263                                                      
REMARK 465     VAL B   264                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     ASP C     3                                                      
REMARK 465     ASP C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     GLY C     6                                                      
REMARK 465     ALA C     7                                                      
REMARK 465     ALA C     8                                                      
REMARK 465     GLY C     9                                                      
REMARK 465     GLY C    10                                                      
REMARK 465     PRO C    11                                                      
REMARK 465     GLY C    12                                                      
REMARK 465     GLY C    13                                                      
REMARK 465     PRO C    14                                                      
REMARK 465     GLY C    15                                                      
REMARK 465     GLY C    16                                                      
REMARK 465     PRO C    17                                                      
REMARK 465     GLY C    18                                                      
REMARK 465     MET C    19                                                      
REMARK 465     GLY C    20                                                      
REMARK 465     ASN C    21                                                      
REMARK 465     ARG C    22                                                      
REMARK 465     GLY C    23                                                      
REMARK 465     GLY C    24                                                      
REMARK 465     PHE C    25                                                      
REMARK 465     ARG C    26                                                      
REMARK 465     GLY C    27                                                      
REMARK 465     GLY C    28                                                      
REMARK 465     PHE C    29                                                      
REMARK 465     GLY C    30                                                      
REMARK 465     SER C    31                                                      
REMARK 465     GLY C    32                                                      
REMARK 465     ILE C    33                                                      
REMARK 465     ARG C    34                                                      
REMARK 465     GLY C    35                                                      
REMARK 465     ARG C    36                                                      
REMARK 465     GLY C    37                                                      
REMARK 465     ARG C    38                                                      
REMARK 465     GLY C    39                                                      
REMARK 465     ARG C    40                                                      
REMARK 465     GLY C    41                                                      
REMARK 465     ARG C    42                                                      
REMARK 465     GLY C    43                                                      
REMARK 465     ARG C    44                                                      
REMARK 465     GLY C    45                                                      
REMARK 465     ARG C    46                                                      
REMARK 465     GLY C    47                                                      
REMARK 465     ARG C    48                                                      
REMARK 465     GLY C    49                                                      
REMARK 465     ALA C    50                                                      
REMARK 465     ARG C    51                                                      
REMARK 465     GLY C    52                                                      
REMARK 465     GLY C    53                                                      
REMARK 465     LYS C    54                                                      
REMARK 465     ALA C    55                                                      
REMARK 465     GLU C    56                                                      
REMARK 465     ASP C    57                                                      
REMARK 465     LYS C    58                                                      
REMARK 465     HIS C   277                                                      
REMARK 465     THR C   278                                                      
REMARK 465     ARG C   279                                                      
REMARK 465     VAL C   280                                                      
REMARK 465     SER C   281                                                      
REMARK 465     VAL C   282                                                      
REMARK 465     GLN C   283                                                      
REMARK 465     ARG C   284                                                      
REMARK 465     THR C   285                                                      
REMARK 465     GLN C   286                                                      
REMARK 465     ALA C   287                                                      
REMARK 465     PRO C   288                                                      
REMARK 465     ALA C   289                                                      
REMARK 465     VAL C   290                                                      
REMARK 465     ALA C   291                                                      
REMARK 465     THR C   292                                                      
REMARK 465     THR C   293                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ARG G   231                                                      
REMARK 465     ARG G   232                                                      
REMARK 465     ARG G   233                                                      
REMARK 465     LEU G   234                                                      
REMARK 465     SER G   235                                                      
REMARK 465     SER G   236                                                      
REMARK 465     LEU G   237                                                      
REMARK 465     ARG G   238                                                      
REMARK 465     ALA G   239                                                      
REMARK 465     SER G   240                                                      
REMARK 465     THR G   241                                                      
REMARK 465     SER G   242                                                      
REMARK 465     LYS G   243                                                      
REMARK 465     SER G   244                                                      
REMARK 465     GLU G   245                                                      
REMARK 465     SER G   246                                                      
REMARK 465     SER G   247                                                      
REMARK 465     GLN G   248                                                      
REMARK 465     LYS G   249                                                      
REMARK 465     MET H     1                                                      
REMARK 465     PHE H     2                                                      
REMARK 465     SER H     3                                                      
REMARK 465     SER H     4                                                      
REMARK 465     SER H     5                                                      
REMARK 465     ALA H     6                                                      
REMARK 465     LYS H     7                                                      
REMARK 465     LEU H   194                                                      
REMARK 465     MET I     1                                                      
REMARK 465     GLY I   207                                                      
REMARK 465     LYS I   208                                                      
REMARK 465     MET J     1                                                      
REMARK 465     GLN J   182                                                      
REMARK 465     GLY J   183                                                      
REMARK 465     GLY J   184                                                      
REMARK 465     ALA J   185                                                      
REMARK 465     GLY J   186                                                      
REMARK 465     ALA J   187                                                      
REMARK 465     GLY J   188                                                      
REMARK 465     ASP J   189                                                      
REMARK 465     ASP J   190                                                      
REMARK 465     GLU J   191                                                      
REMARK 465     GLU J   192                                                      
REMARK 465     GLU J   193                                                      
REMARK 465     ASP J   194                                                      
REMARK 465     MET L     1                                                      
REMARK 465     LYS L   153                                                      
REMARK 465     GLN L   154                                                      
REMARK 465     PHE L   155                                                      
REMARK 465     GLN L   156                                                      
REMARK 465     LYS L   157                                                      
REMARK 465     PHE L   158                                                      
REMARK 465     MET N     1                                                      
REMARK 465     ALA N   151                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     PRO O     3                                                      
REMARK 465     ARG O     4                                                      
REMARK 465     LYS O     5                                                      
REMARK 465     GLY O     6                                                      
REMARK 465     LYS O     7                                                      
REMARK 465     GLU O     8                                                      
REMARK 465     LYS O     9                                                      
REMARK 465     LYS O    10                                                      
REMARK 465     GLU O    11                                                      
REMARK 465     GLU O    12                                                      
REMARK 465     GLN O    13                                                      
REMARK 465     VAL O    14                                                      
REMARK 465     ILE O    15                                                      
REMARK 465     SER O    16                                                      
REMARK 465     PHE V    83                                                      
REMARK 465     MET W     1                                                      
REMARK 465     MET X     1                                                      
REMARK 465     SER X   143                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     ASN Y     2                                                      
REMARK 465     ALA Y   127                                                      
REMARK 465     GLY Y   128                                                      
REMARK 465     LYS Y   129                                                      
REMARK 465     LYS Y   130                                                      
REMARK 465     PRO Y   131                                                      
REMARK 465     LYS Y   132                                                      
REMARK 465     GLU Y   133                                                      
REMARK 465     MET b     1                                                      
REMARK 465     HIS b    84                                                      
REMARK 465     LYS e     1                                                      
REMARK 465     VAL e     2                                                      
REMARK 465     HIS e     3                                                      
REMARK 465     GLY e     4                                                      
REMARK 465     MET x     1                                                      
REMARK 465     GLU x     2                                                      
REMARK 465     SER x     3                                                      
REMARK 465     GLU x     4                                                      
REMARK 465     MET x     5                                                      
REMARK 465     GLU x     6                                                      
REMARK 465     THR x     7                                                      
REMARK 465     GLN x     8                                                      
REMARK 465     SER x     9                                                      
REMARK 465     ALA x    10                                                      
REMARK 465     ARG x    11                                                      
REMARK 465     ALA x    12                                                      
REMARK 465     GLU x    13                                                      
REMARK 465     GLU x    14                                                      
REMARK 465     GLY x    15                                                      
REMARK 465     PHE x    16                                                      
REMARK 465     THR x    17                                                      
REMARK 465     GLN x    18                                                      
REMARK 465     VAL x    19                                                      
REMARK 465     THR x    20                                                      
REMARK 465     ARG x    21                                                      
REMARK 465     LYS x    22                                                      
REMARK 465     GLY x    23                                                      
REMARK 465     GLY x    24                                                      
REMARK 465     ARG x    25                                                      
REMARK 465     ARG x    26                                                      
REMARK 465     ALA x    27                                                      
REMARK 465     LYS x    28                                                      
REMARK 465     LYS x    29                                                      
REMARK 465     ARG x    30                                                      
REMARK 465     GLN x    31                                                      
REMARK 465     ALA x    32                                                      
REMARK 465     GLU x    33                                                      
REMARK 465     GLN x    34                                                      
REMARK 465     LEU x    35                                                      
REMARK 465     SER x    36                                                      
REMARK 465     ALA x    37                                                      
REMARK 465     ALA x    38                                                      
REMARK 465     GLY x    39                                                      
REMARK 465     GLU x    40                                                      
REMARK 465     GLY x    41                                                      
REMARK 465     GLY x    42                                                      
REMARK 465     ASP x    43                                                      
REMARK 465     ALA x    44                                                      
REMARK 465     GLY x    45                                                      
REMARK 465     ARG x    46                                                      
REMARK 465     MET x    47                                                      
REMARK 465     ASP x    48                                                      
REMARK 465     THR x    49                                                      
REMARK 465     GLU x    50                                                      
REMARK 465     GLU x    51                                                      
REMARK 465     ALA x    52                                                      
REMARK 465     ARG x    53                                                      
REMARK 465     PRO x    54                                                      
REMARK 465     ALA x    55                                                      
REMARK 465     LYS x    56                                                      
REMARK 465     ARG x    57                                                      
REMARK 465     PRO x    58                                                      
REMARK 465     VAL x    59                                                      
REMARK 465     PHE x    60                                                      
REMARK 465     PRO x    61                                                      
REMARK 465     PRO x    62                                                      
REMARK 465     LEU x    63                                                      
REMARK 465     CYS x    64                                                      
REMARK 465     GLY x    65                                                      
REMARK 465     ASP x    66                                                      
REMARK 465     GLY x    67                                                      
REMARK 465     LEU x    68                                                      
REMARK 465     LEU x    69                                                      
REMARK 465     SER x    70                                                      
REMARK 465     GLY x    71                                                      
REMARK 465     LYS x    72                                                      
REMARK 465     ARG x   251                                                      
REMARK 465     PHE x   252                                                      
REMARK 465     MET y     1                                                      
REMARK 465     ALA y     2                                                      
REMARK 465     PRO y     3                                                      
REMARK 465     VAL y     4                                                      
REMARK 465     GLU y     5                                                      
REMARK 465     HIS y     6                                                      
REMARK 465     TYR y   132                                                      
REMARK 465     LYS y   133                                                      
REMARK 465     PRO y   134                                                      
REMARK 465     LYS y   135                                                      
REMARK 465     PRO y   136                                                      
REMARK 465     PRO y   137                                                      
REMARK 465     GLN y   138                                                      
REMARK 465     GLU y   139                                                      
REMARK 465     THR y   140                                                      
REMARK 465     GLU y   141                                                      
REMARK 465     LYS y   142                                                      
REMARK 465     GLY y   143                                                      
REMARK 465     HIS y   144                                                      
REMARK 465     SER y   145                                                      
REMARK 465     ALA y   146                                                      
REMARK 465     CYS y   147                                                      
REMARK 465     GLU y   148                                                      
REMARK 465     PRO y   149                                                      
REMARK 465     GLU y   150                                                      
REMARK 465     ASN y   151                                                      
REMARK 465     LEU y   152                                                      
REMARK 465     GLU y   153                                                      
REMARK 465     PHE y   154                                                      
REMARK 465     SER y   155                                                      
REMARK 465     SER y   156                                                      
REMARK 465     PHE y   157                                                      
REMARK 465     MET y   158                                                      
REMARK 465     PHE y   159                                                      
REMARK 465     TRP y   160                                                      
REMARK 465     ARG y   161                                                      
REMARK 465     ASN y   162                                                      
REMARK 465     PRO y   163                                                      
REMARK 465     LEU y   164                                                      
REMARK 465     PRO y   165                                                      
REMARK 465     ASN y   166                                                      
REMARK 465     ILE y   167                                                      
REMARK 465     ASP y   168                                                      
REMARK 465     HIS y   169                                                      
REMARK 465     GLU y   170                                                      
REMARK 465     LEU y   171                                                      
REMARK 465     GLN y   172                                                      
REMARK 465     GLU y   173                                                      
REMARK 465     LEU y   174                                                      
REMARK 465     LEU y   175                                                      
REMARK 465     ILE y   176                                                      
REMARK 465     ASP y   177                                                      
REMARK 465     ARG y   178                                                      
REMARK 465     GLY y   179                                                      
REMARK 465     GLU y   180                                                      
REMARK 465     ASP y   181                                                      
REMARK 465     VAL y   182                                                      
REMARK 465     PRO y   183                                                      
REMARK 465     SER y   184                                                      
REMARK 465     GLU y   185                                                      
REMARK 465     GLU y   186                                                      
REMARK 465     GLU y   187                                                      
REMARK 465     GLU y   188                                                      
REMARK 465     GLU y   189                                                      
REMARK 465     GLU y   190                                                      
REMARK 465     GLU y   191                                                      
REMARK 465     ASN y   192                                                      
REMARK 465     GLY y   193                                                      
REMARK 465     PHE y   194                                                      
REMARK 465     GLU y   195                                                      
REMARK 465     ASP y   196                                                      
REMARK 465     ARG y   197                                                      
REMARK 465     LYS y   198                                                      
REMARK 465     ASP y   199                                                      
REMARK 465     ASP y   200                                                      
REMARK 465     SER y   201                                                      
REMARK 465     ASP y   202                                                      
REMARK 465     ASP y   203                                                      
REMARK 465     ASP y   204                                                      
REMARK 465     GLY y   205                                                      
REMARK 465     GLN y   223                                                      
REMARK 465     CYS y   224                                                      
REMARK 465     ASP y   225                                                      
REMARK 465     VAL y   226                                                      
REMARK 465     PRO y   227                                                      
REMARK 465     GLU y   228                                                      
REMARK 465     ASP y   229                                                      
REMARK 465     MET u     1                                                      
REMARK 465     ALA u     2                                                      
REMARK 465     ALA u     3                                                      
REMARK 465     HIS u     4                                                      
REMARK 465     ARG u     5                                                      
REMARK 465     PRO u     6                                                      
REMARK 465     GLY u     7                                                      
REMARK 465     PRO u     8                                                      
REMARK 465     LEU u     9                                                      
REMARK 465     LYS u    10                                                      
REMARK 465     GLN u    11                                                      
REMARK 465     GLN u    12                                                      
REMARK 465     ASN u    13                                                      
REMARK 465     LYS u    14                                                      
REMARK 465     ALA u    15                                                      
REMARK 465     HIS u    16                                                      
REMARK 465     LYS u    17                                                      
REMARK 465     GLY u    18                                                      
REMARK 465     GLY u    19                                                      
REMARK 465     ARG u    20                                                      
REMARK 465     HIS u    21                                                      
REMARK 465     ARG u    22                                                      
REMARK 465     GLY u    23                                                      
REMARK 465     ARG u    24                                                      
REMARK 465     GLY u    25                                                      
REMARK 465     SER u    26                                                      
REMARK 465     ALA u    27                                                      
REMARK 465     GLN u    28                                                      
REMARK 465     ARG u    29                                                      
REMARK 465     ASP u    30                                                      
REMARK 465     GLY u    31                                                      
REMARK 465     LYS u    32                                                      
REMARK 465     GLY u    33                                                      
REMARK 465     ARG u    34                                                      
REMARK 465     LEU u    35                                                      
REMARK 465     ALA u    36                                                      
REMARK 465     LEU u    37                                                      
REMARK 465     LYS u    38                                                      
REMARK 465     THR u    39                                                      
REMARK 465     LEU u    40                                                      
REMARK 465     SER u    41                                                      
REMARK 465     LYS u    42                                                      
REMARK 465     LYS u    43                                                      
REMARK 465     VAL u    44                                                      
REMARK 465     ARG u    45                                                      
REMARK 465     LYS u    46                                                      
REMARK 465     ARG u   106                                                      
REMARK 465     ASP u   107                                                      
REMARK 465     THR u   108                                                      
REMARK 465     ARG u   314                                                      
REMARK 465     GLY u   315                                                      
REMARK 465     ILE u   316                                                      
REMARK 465     LYS u   317                                                      
REMARK 465     PRO u   318                                                      
REMARK 465     GLN u   319                                                      
REMARK 465     LYS u   320                                                      
REMARK 465     ASP u   321                                                      
REMARK 465     PRO u   322                                                      
REMARK 465     ASP u   323                                                      
REMARK 465     MET u   324                                                      
REMARK 465     ALA u   325                                                      
REMARK 465     MET u   326                                                      
REMARK 465     GLU u   327                                                      
REMARK 465     ILE u   328                                                      
REMARK 465     CYS u   329                                                      
REMARK 465     ALA u   330                                                      
REMARK 465     THR u   331                                                      
REMARK 465     ASP u   332                                                      
REMARK 465     ALA u   333                                                      
REMARK 465     VAL u   334                                                      
REMARK 465     ASP u   335                                                      
REMARK 465     ASP u   336                                                      
REMARK 465     MET u   337                                                      
REMARK 465     GLU u   338                                                      
REMARK 465     GLU u   339                                                      
REMARK 465     GLY u   340                                                      
REMARK 465     LEU u   341                                                      
REMARK 465     MET u   364                                                      
REMARK 465     GLU u   365                                                      
REMARK 465     GLY u   366                                                      
REMARK 465     GLU u   367                                                      
REMARK 465     GLN u   368                                                      
REMARK 465     THR u   369                                                      
REMARK 465     TRP u   370                                                      
REMARK 465     PRO u   371                                                      
REMARK 465     THR u   372                                                      
REMARK 465     GLU u   373                                                      
REMARK 465     GLU u   374                                                      
REMARK 465     GLU u   375                                                      
REMARK 465     LEU u   376                                                      
REMARK 465     SER u   377                                                      
REMARK 465     GLU u   378                                                      
REMARK 465     ALA u   379                                                      
REMARK 465     LYS u   380                                                      
REMARK 465     ASP u   381                                                      
REMARK 465     PHE u   382                                                      
REMARK 465     LEU u   383                                                      
REMARK 465     LYS u   384                                                      
REMARK 465     GLU u   385                                                      
REMARK 465     SER u   386                                                      
REMARK 465     SER u   387                                                      
REMARK 465     LYS u   388                                                      
REMARK 465     VAL u   389                                                      
REMARK 465     VAL u   390                                                      
REMARK 465     LYS u   391                                                      
REMARK 465     LEU u   406                                                      
REMARK 465     ASP u   407                                                      
REMARK 465     GLY u   408                                                      
REMARK 465     GLY u   409                                                      
REMARK 465     SER u   410                                                      
REMARK 465     GLN u   411                                                      
REMARK 465     SER u   412                                                      
REMARK 465     GLY u   413                                                      
REMARK 465     GLY u   414                                                      
REMARK 465     GLU u   415                                                      
REMARK 465     GLY u   416                                                      
REMARK 465     ASP u   417                                                      
REMARK 465     GLU u   418                                                      
REMARK 465     TYR u   419                                                      
REMARK 465     GLU u   420                                                      
REMARK 465     TYR u   421                                                      
REMARK 465     ASP u   422                                                      
REMARK 465     ASP u   423                                                      
REMARK 465     MET u   424                                                      
REMARK 465     GLU u   425                                                      
REMARK 465     HIS u   426                                                      
REMARK 465     GLU u   427                                                      
REMARK 465     ASP u   428                                                      
REMARK 465     PHE u   429                                                      
REMARK 465     MET u   430                                                      
REMARK 465     GLU u   431                                                      
REMARK 465     GLU u   432                                                      
REMARK 465     GLU u   433                                                      
REMARK 465     SER u   434                                                      
REMARK 465     GLN u   435                                                      
REMARK 465     ASP u   436                                                      
REMARK 465     GLU u   437                                                      
REMARK 465     SER u   438                                                      
REMARK 465     SER u   439                                                      
REMARK 465     GLU u   440                                                      
REMARK 465     GLU u   441                                                      
REMARK 465     GLU u   442                                                      
REMARK 465     GLU u   443                                                      
REMARK 465     GLU u   444                                                      
REMARK 465     TYR u   445                                                      
REMARK 465     GLU u   446                                                      
REMARK 465     THR u   447                                                      
REMARK 465     MET u   448                                                      
REMARK 465     THR u   449                                                      
REMARK 465     ILE u   450                                                      
REMARK 465     GLY u   451                                                      
REMARK 465     GLU u   452                                                      
REMARK 465     SER u   453                                                      
REMARK 465     VAL u   454                                                      
REMARK 465     HIS u   455                                                      
REMARK 465     ASP u   456                                                      
REMARK 465     ASP u   457                                                      
REMARK 465     LEU u   458                                                      
REMARK 465     TYR u   459                                                      
REMARK 465     ASP u   460                                                      
REMARK 465     LYS u   461                                                      
REMARK 465     LYS u   462                                                      
REMARK 465     VAL u   463                                                      
REMARK 465     GLU u   793                                                      
REMARK 465     ILE u   794                                                      
REMARK 465     SER u   795                                                      
REMARK 465     SER u   796                                                      
REMARK 465     THR u   797                                                      
REMARK 465     VAL u   798                                                      
REMARK 465     PRO u   799                                                      
REMARK 465     GLN u   800                                                      
REMARK 465     GLY u   801                                                      
REMARK 465     GLY u   802                                                      
REMARK 465     MET u   803                                                      
REMARK 465     GLU u   804                                                      
REMARK 465     MET w     1                                                      
REMARK 465     PRO w     2                                                      
REMARK 465     LYS w     3                                                      
REMARK 465     PHE w     4                                                      
REMARK 465     LYS w     5                                                      
REMARK 465     ALA w     6                                                      
REMARK 465     ALA w     7                                                      
REMARK 465     ARG w     8                                                      
REMARK 465     GLY w     9                                                      
REMARK 465     VAL w    10                                                      
REMARK 465     GLY w    11                                                      
REMARK 465     GLY w    12                                                      
REMARK 465     GLN w    13                                                      
REMARK 465     GLU w    14                                                      
REMARK 465     LYS w    15                                                      
REMARK 465     HIS w    16                                                      
REMARK 465     ALA w    17                                                      
REMARK 465     PRO w    18                                                      
REMARK 465     LEU w    19                                                      
REMARK 465     ALA w    20                                                      
REMARK 465     ASP w    21                                                      
REMARK 465     GLN w    22                                                      
REMARK 465     ILE w    23                                                      
REMARK 465     LEU w    24                                                      
REMARK 465     ALA w    25                                                      
REMARK 465     GLY w    26                                                      
REMARK 465     ASN w    27                                                      
REMARK 465     ALA w    28                                                      
REMARK 465     VAL w    29                                                      
REMARK 465     ARG w    30                                                      
REMARK 465     ALA w    31                                                      
REMARK 465     GLY w    32                                                      
REMARK 465     VAL w    33                                                      
REMARK 465     ARG w    34                                                      
REMARK 465     GLU w    35                                                      
REMARK 465     LYS w    36                                                      
REMARK 465     ARG w    37                                                      
REMARK 465     ARG w    38                                                      
REMARK 465     GLY w    39                                                      
REMARK 465     ARG w    40                                                      
REMARK 465     GLY w    41                                                      
REMARK 465     THR w    42                                                      
REMARK 465     GLY w    43                                                      
REMARK 465     GLU w    44                                                      
REMARK 465     ALA w    45                                                      
REMARK 465     GLU w    46                                                      
REMARK 465     GLU w    47                                                      
REMARK 465     GLU w    48                                                      
REMARK 465     TYR w    49                                                      
REMARK 465     VAL w    50                                                      
REMARK 465     GLY w    51                                                      
REMARK 465     PRO w    52                                                      
REMARK 465     ARG w    53                                                      
REMARK 465     LEU w    54                                                      
REMARK 465     SER w    55                                                      
REMARK 465     ARG w    56                                                      
REMARK 465     ARG w    57                                                      
REMARK 465     ILE w    58                                                      
REMARK 465     LEU w    59                                                      
REMARK 465     GLN w    60                                                      
REMARK 465     GLN w    61                                                      
REMARK 465     ALA w    62                                                      
REMARK 465     ARG w    63                                                      
REMARK 465     GLN w    64                                                      
REMARK 465     GLN w    65                                                      
REMARK 465     GLN w    66                                                      
REMARK 465     GLU w    67                                                      
REMARK 465     GLU w    68                                                      
REMARK 465     LEU w    69                                                      
REMARK 465     GLU w    70                                                      
REMARK 465     ALA w    71                                                      
REMARK 465     GLU w    72                                                      
REMARK 465     HIS w    73                                                      
REMARK 465     GLY w    74                                                      
REMARK 465     THR w    75                                                      
REMARK 465     GLY w    76                                                      
REMARK 465     ASP w    77                                                      
REMARK 465     LYS w    78                                                      
REMARK 465     PRO w    79                                                      
REMARK 465     ALA w    80                                                      
REMARK 465     ALA w    81                                                      
REMARK 465     PRO w    82                                                      
REMARK 465     ARG w    83                                                      
REMARK 465     GLU w    84                                                      
REMARK 465     ARG w    85                                                      
REMARK 465     THR w    86                                                      
REMARK 465     THR w    87                                                      
REMARK 465     ARG w    88                                                      
REMARK 465     LEU w    89                                                      
REMARK 465     GLY w    90                                                      
REMARK 465     PRO w    91                                                      
REMARK 465     ARG w    92                                                      
REMARK 465     MET w    93                                                      
REMARK 465     PRO w    94                                                      
REMARK 465     GLN w    95                                                      
REMARK 465     ASP w    96                                                      
REMARK 465     GLY w    97                                                      
REMARK 465     SER w    98                                                      
REMARK 465     ASP w    99                                                      
REMARK 465     ASP w   100                                                      
REMARK 465     GLU w   101                                                      
REMARK 465     ASP w   102                                                      
REMARK 465     GLU w   103                                                      
REMARK 465     GLU w   104                                                      
REMARK 465     TRP w   105                                                      
REMARK 465     PRO w   106                                                      
REMARK 465     THR w   107                                                      
REMARK 465     LEU w   108                                                      
REMARK 465     GLU w   109                                                      
REMARK 465     LYS w   110                                                      
REMARK 465     ALA w   111                                                      
REMARK 465     ALA w   112                                                      
REMARK 465     THR w   113                                                      
REMARK 465     MET w   114                                                      
REMARK 465     THR w   115                                                      
REMARK 465     ALA w   116                                                      
REMARK 465     ALA w   117                                                      
REMARK 465     GLY w   118                                                      
REMARK 465     HIS w   119                                                      
REMARK 465     HIS w   120                                                      
REMARK 465     ALA w   121                                                      
REMARK 465     GLU w   122                                                      
REMARK 465     VAL w   123                                                      
REMARK 465     VAL w   124                                                      
REMARK 465     VAL w   125                                                      
REMARK 465     ASP w   126                                                      
REMARK 465     PRO w   127                                                      
REMARK 465     GLU w   128                                                      
REMARK 465     ASP w   129                                                      
REMARK 465     GLU w   130                                                      
REMARK 465     ARG w   131                                                      
REMARK 465     ALA w   132                                                      
REMARK 465     ILE w   133                                                      
REMARK 465     GLU w   134                                                      
REMARK 465     MET w   135                                                      
REMARK 465     PHE w   136                                                      
REMARK 465     MET w   137                                                      
REMARK 465     ASN w   138                                                      
REMARK 465     LYS w   139                                                      
REMARK 465     ASN w   140                                                      
REMARK 465     PRO w   141                                                      
REMARK 465     PRO w   142                                                      
REMARK 465     ALA w   143                                                      
REMARK 465     ARG w   144                                                      
REMARK 465     ARG w   145                                                      
REMARK 465     THR w   146                                                      
REMARK 465     LEU w   147                                                      
REMARK 465     ALA w   148                                                      
REMARK 465     ASP w   149                                                      
REMARK 465     ILE w   150                                                      
REMARK 465     ILE w   151                                                      
REMARK 465     MET w   152                                                      
REMARK 465     GLU w   153                                                      
REMARK 465     LYS w   154                                                      
REMARK 465     LEU w   155                                                      
REMARK 465     THR w   156                                                      
REMARK 465     GLU w   157                                                      
REMARK 465     LYS w   158                                                      
REMARK 465     GLN w   159                                                      
REMARK 465     THR w   160                                                      
REMARK 465     GLU w   161                                                      
REMARK 465     VAL w   162                                                      
REMARK 465     GLU w   163                                                      
REMARK 465     THR w   164                                                      
REMARK 465     VAL w   165                                                      
REMARK 465     MET w   166                                                      
REMARK 465     SER w   167                                                      
REMARK 465     GLU w   168                                                      
REMARK 465     VAL w   169                                                      
REMARK 465     SER w   170                                                      
REMARK 465     GLY w   171                                                      
REMARK 465     PHE w   172                                                      
REMARK 465     PRO w   173                                                      
REMARK 465     MET w   174                                                      
REMARK 465     PRO w   175                                                      
REMARK 465     GLN w   176                                                      
REMARK 465     LEU w   177                                                      
REMARK 465     ASP w   178                                                      
REMARK 465     ASP w   428                                                      
REMARK 465     VAL w   429                                                      
REMARK 465     GLU w   430                                                      
REMARK 465     ASP w   431                                                      
REMARK 465     VAL w   432                                                      
REMARK 465     PRO w   433                                                      
REMARK 465     ILE w   434                                                      
REMARK 465     THR w   435                                                      
REMARK 465     VAL w   436                                                      
REMARK 465     GLU w   437                                                      
REMARK 465     MET v     1                                                      
REMARK 465     GLY v     2                                                      
REMARK 465     LYS v     3                                                      
REMARK 465     VAL v     4                                                      
REMARK 465     ASN v     5                                                      
REMARK 465     VAL v     6                                                      
REMARK 465     ALA v     7                                                      
REMARK 465     LYS v     8                                                      
REMARK 465     ARG v   129                                                      
REMARK 465     THR v   130                                                      
REMARK 465     SER v   131                                                      
REMARK 465     PHE v   132                                                      
REMARK 465     ARG v   133                                                      
REMARK 465     ASN v   134                                                      
REMARK 465     LEU v   135                                                      
REMARK 465     LYS v   136                                                      
REMARK 465     ASN v   137                                                      
REMARK 465     LYS v   138                                                      
REMARK 465     ARG v   139                                                      
REMARK 465     ASP v   140                                                      
REMARK 465     TYR v   141                                                      
REMARK 465     HIS v   142                                                      
REMARK 465     LYS v   143                                                      
REMARK 465     HIS v   144                                                      
REMARK 465     VAL v   300                                                      
REMARK 465     SER v   301                                                      
REMARK 465     ALA v   302                                                      
REMARK 465     SER v   303                                                      
REMARK 465     GLY v   304                                                      
REMARK 465     TYR v   305                                                      
REMARK 465     THR v   306                                                      
REMARK 465     LYS v   307                                                      
REMARK 465     GLU v   308                                                      
REMARK 465     MET v   309                                                      
REMARK 465     GLN v   310                                                      
REMARK 465     ALA v   311                                                      
REMARK 465     ASP v   312                                                      
REMARK 465     ASP v   313                                                      
REMARK 465     GLU v   314                                                      
REMARK 465     LEU v   315                                                      
REMARK 465     LEU v   316                                                      
REMARK 465     HIS v   317                                                      
REMARK 465     PRO v   318                                                      
REMARK 465     LEU v   319                                                      
REMARK 465     GLY v   320                                                      
REMARK 465     PRO v   321                                                      
REMARK 465     ASP v   322                                                      
REMARK 465     ASP v   323                                                      
REMARK 465     LYS v   324                                                      
REMARK 465     ASN v   325                                                      
REMARK 465     ILE v   326                                                      
REMARK 465     GLU v   327                                                      
REMARK 465     THR v   328                                                      
REMARK 465     LYS v   329                                                      
REMARK 465     GLU v   330                                                      
REMARK 465     GLY v   331                                                      
REMARK 465     SER v   332                                                      
REMARK 465     GLU v   333                                                      
REMARK 465     PHE v   334                                                      
REMARK 465     SER v   335                                                      
REMARK 465     PHE v   336                                                      
REMARK 465     SER v   337                                                      
REMARK 465     ASP v   338                                                      
REMARK 465     GLY v   339                                                      
REMARK 465     GLU v   340                                                      
REMARK 465     VAL v   341                                                      
REMARK 465     ALA v   342                                                      
REMARK 465     GLU v   343                                                      
REMARK 465     LYS v   344                                                      
REMARK 465     ALA v   345                                                      
REMARK 465     GLU v   346                                                      
REMARK 465     VAL v   347                                                      
REMARK 465     TYR v   348                                                      
REMARK 465     GLY v   349                                                      
REMARK 465     SER v   350                                                      
REMARK 465     GLU v   351                                                      
REMARK 465     ASN v   352                                                      
REMARK 465     GLU v   353                                                      
REMARK 465     SER v   354                                                      
REMARK 465     GLU v   355                                                      
REMARK 465     ARG v   356                                                      
REMARK 465     ASN v   357                                                      
REMARK 465     CYS v   358                                                      
REMARK 465     LEU v   359                                                      
REMARK 465     GLU v   360                                                      
REMARK 465     GLU v   361                                                      
REMARK 465     SER v   362                                                      
REMARK 465     GLU v   363                                                      
REMARK 465     GLY v   364                                                      
REMARK 465     CYS v   365                                                      
REMARK 465     TYR v   366                                                      
REMARK 465     CYS v   367                                                      
REMARK 465     ARG v   368                                                      
REMARK 465     SER v   369                                                      
REMARK 465     SER v   370                                                      
REMARK 465     GLY v   371                                                      
REMARK 465     ASP v   372                                                      
REMARK 465     PRO v   373                                                      
REMARK 465     GLU v   374                                                      
REMARK 465     GLN v   375                                                      
REMARK 465     ILE v   376                                                      
REMARK 465     LYS v   377                                                      
REMARK 465     GLU v   378                                                      
REMARK 465     ASP v   379                                                      
REMARK 465     SER v   380                                                      
REMARK 465     LEU v   381                                                      
REMARK 465     SER v   382                                                      
REMARK 465     GLU v   383                                                      
REMARK 465     GLU v   384                                                      
REMARK 465     SER v   385                                                      
REMARK 465     ALA v   386                                                      
REMARK 465     ASP v   387                                                      
REMARK 465     ALA v   388                                                      
REMARK 465     ARG v   389                                                      
REMARK 465     SER v   390                                                      
REMARK 465     PHE v   391                                                      
REMARK 465     GLU v   392                                                      
REMARK 465     MET v   393                                                      
REMARK 465     THR v   394                                                      
REMARK 465     GLU v   395                                                      
REMARK 465     PHE v   396                                                      
REMARK 465     ASN v   397                                                      
REMARK 465     GLN v   398                                                      
REMARK 465     ALA v   399                                                      
REMARK 465     LEU v   400                                                      
REMARK 465     GLU v   401                                                      
REMARK 465     GLU v   402                                                      
REMARK 465     ILE v   403                                                      
REMARK 465     LYS v   404                                                      
REMARK 465     GLY v   405                                                      
REMARK 465     GLN v   406                                                      
REMARK 465     VAL v   407                                                      
REMARK 465     VAL v   408                                                      
REMARK 465     GLU v   409                                                      
REMARK 465     ASN v   410                                                      
REMARK 465     ASN v   411                                                      
REMARK 465     SER v   412                                                      
REMARK 465     VAL v   413                                                      
REMARK 465     THR v   414                                                      
REMARK 465     GLU v   415                                                      
REMARK 465     PHE v   416                                                      
REMARK 465     SER v   417                                                      
REMARK 465     GLU v   418                                                      
REMARK 465     GLU v   419                                                      
REMARK 465     LYS v   420                                                      
REMARK 465     ASN v   421                                                      
REMARK 465     ARG v   422                                                      
REMARK 465     THR v   423                                                      
REMARK 465     GLU v   424                                                      
REMARK 465     ASN v   425                                                      
REMARK 465     TYR v   426                                                      
REMARK 465     ASN v   427                                                      
REMARK 465     ARG v   428                                                      
REMARK 465     GLN v   429                                                      
REMARK 465     ASP v   430                                                      
REMARK 465     GLY v   431                                                      
REMARK 465     GLN v   432                                                      
REMARK 465     ARG v   433                                                      
REMARK 465     VAL v   434                                                      
REMARK 465     GLN v   435                                                      
REMARK 465     GLY v   436                                                      
REMARK 465     GLY v   437                                                      
REMARK 465     VAL v   438                                                      
REMARK 465     PRO v   439                                                      
REMARK 465     ALA v   440                                                      
REMARK 465     GLY v   441                                                      
REMARK 465     SER v   442                                                      
REMARK 465     ASP v   443                                                      
REMARK 465     GLU v   444                                                      
REMARK 465     TYR v   445                                                      
REMARK 465     GLU v   446                                                      
REMARK 465     ASP v   447                                                      
REMARK 465     GLU v   448                                                      
REMARK 465     CYS v   449                                                      
REMARK 465     PRO v   450                                                      
REMARK 465     HIS v   451                                                      
REMARK 465     LEU v   452                                                      
REMARK 465     ILE v   453                                                      
REMARK 465     ALA v   454                                                      
REMARK 465     LEU v   455                                                      
REMARK 465     SER v   456                                                      
REMARK 465     SER v   457                                                      
REMARK 465     LEU v   458                                                      
REMARK 465     ASN v   459                                                      
REMARK 465     ARG v   460                                                      
REMARK 465     GLU v   461                                                      
REMARK 465     PHE v   462                                                      
REMARK 465     ARG v   463                                                      
REMARK 465     PRO v   464                                                      
REMARK 465     PHE v   465                                                      
REMARK 465     ARG v   466                                                      
REMARK 465     ASP v   467                                                      
REMARK 465     GLU v   468                                                      
REMARK 465     GLU v   469                                                      
REMARK 465     ASN v   470                                                      
REMARK 465     VAL v   471                                                      
REMARK 465     GLY v   472                                                      
REMARK 465     ALA v   473                                                      
REMARK 465     MET v   474                                                      
REMARK 465     ASN v   475                                                      
REMARK 465     GLN v   476                                                      
REMARK 465     TYR v   477                                                      
REMARK 465     ARG v   478                                                      
REMARK 465     THR v   479                                                      
REMARK 465     ARG v   480                                                      
REMARK 465     THR v   481                                                      
REMARK 465     LEU v   482                                                      
REMARK 465     SER v   483                                                      
REMARK 465     ILE v   484                                                      
REMARK 465     THR v   485                                                      
REMARK 465     SER v   486                                                      
REMARK 465     SER v   487                                                      
REMARK 465     GLY v   488                                                      
REMARK 465     SER v   489                                                      
REMARK 465     ALA v   490                                                      
REMARK 465     VAL v   491                                                      
REMARK 465     SER v   492                                                      
REMARK 465     CYS v   493                                                      
REMARK 465     GLU v   525                                                      
REMARK 465     GLU v   545                                                      
REMARK 465     ALA v   546                                                      
REMARK 465     ALA v   547                                                      
REMARK 465     SER v   548                                                      
REMARK 465     PHE v   549                                                      
REMARK 465     TRP v   550                                                      
REMARK 465     GLY v   551                                                      
REMARK 465     GLU v   552                                                      
REMARK 465     MET t     1                                                      
REMARK 465     PRO t     2                                                      
REMARK 465     HIS t     3                                                      
REMARK 465     ARG t     4                                                      
REMARK 465     LYS t     5                                                      
REMARK 465     LYS t     6                                                      
REMARK 465     LYS t     7                                                      
REMARK 465     PRO t     8                                                      
REMARK 465     PHE t     9                                                      
REMARK 465     ILE t    10                                                      
REMARK 465     GLU t    11                                                      
REMARK 465     LYS t    12                                                      
REMARK 465     LYS t    13                                                      
REMARK 465     LYS t    14                                                      
REMARK 465     ALA t    15                                                      
REMARK 465     VAL t    16                                                      
REMARK 465     SER t    17                                                      
REMARK 465     PHE t    18                                                      
REMARK 465     HIS t    19                                                      
REMARK 465     LEU t    20                                                      
REMARK 465     VAL t    21                                                      
REMARK 465     HIS t    22                                                      
REMARK 465     ARG t    23                                                      
REMARK 465     SER t    24                                                      
REMARK 465     GLN t    25                                                      
REMARK 465     ARG t    26                                                      
REMARK 465     ASP t    27                                                      
REMARK 465     PRO t    28                                                      
REMARK 465     LEU t    29                                                      
REMARK 465     ALA t    30                                                      
REMARK 465     ALA t    31                                                      
REMARK 465     ASP t    32                                                      
REMARK 465     GLU t    33                                                      
REMARK 465     SER t    34                                                      
REMARK 465     ALA t    35                                                      
REMARK 465     PRO t    36                                                      
REMARK 465     GLN t    37                                                      
REMARK 465     ARG t    38                                                      
REMARK 465     VAL t    39                                                      
REMARK 465     LEU t    40                                                      
REMARK 465     LEU t    41                                                      
REMARK 465     PRO t    42                                                      
REMARK 465     THR t    43                                                      
REMARK 465     GLN t    44                                                      
REMARK 465     LYS t    45                                                      
REMARK 465     ILE t    46                                                      
REMARK 465     ASP t    47                                                      
REMARK 465     ASN t    48                                                      
REMARK 465     GLU t    49                                                      
REMARK 465     GLU t    50                                                      
REMARK 465     ARG t    51                                                      
REMARK 465     ARG t    52                                                      
REMARK 465     ALA t    53                                                      
REMARK 465     GLU t    54                                                      
REMARK 465     GLN t    55                                                      
REMARK 465     ARG t    56                                                      
REMARK 465     LYS t    57                                                      
REMARK 465     TYR t    58                                                      
REMARK 465     GLY t    59                                                      
REMARK 465     VAL t    60                                                      
REMARK 465     PHE t    61                                                      
REMARK 465     PHE t    62                                                      
REMARK 465     ASP t    63                                                      
REMARK 465     ASP t    64                                                      
REMARK 465     ASP t    65                                                      
REMARK 465     TYR t    66                                                      
REMARK 465     ASP t    67                                                      
REMARK 465     TYR t    68                                                      
REMARK 465     LEU t    69                                                      
REMARK 465     GLN t    70                                                      
REMARK 465     HIS t    71                                                      
REMARK 465     LEU t    72                                                      
REMARK 465     LYS t    73                                                      
REMARK 465     GLU t    74                                                      
REMARK 465     PRO t    75                                                      
REMARK 465     SER t    76                                                      
REMARK 465     GLY t    77                                                      
REMARK 465     PRO t    78                                                      
REMARK 465     SER t    79                                                      
REMARK 465     GLU t    80                                                      
REMARK 465     LEU t    81                                                      
REMARK 465     ILE t    82                                                      
REMARK 465     PRO t    83                                                      
REMARK 465     SER t    84                                                      
REMARK 465     SER t    85                                                      
REMARK 465     THR t    86                                                      
REMARK 465     PHE t    87                                                      
REMARK 465     SER t    88                                                      
REMARK 465     ALA t    89                                                      
REMARK 465     HIS t    90                                                      
REMARK 465     ASN t    91                                                      
REMARK 465     ARG t    92                                                      
REMARK 465     ARG t    93                                                      
REMARK 465     GLU t    94                                                      
REMARK 465     GLU t    95                                                      
REMARK 465     LYS t    96                                                      
REMARK 465     GLU t    97                                                      
REMARK 465     GLU t    98                                                      
REMARK 465     THR t    99                                                      
REMARK 465     LEU t   100                                                      
REMARK 465     VAL t   101                                                      
REMARK 465     ILE t   102                                                      
REMARK 465     PRO t   103                                                      
REMARK 465     SER t   104                                                      
REMARK 465     THR t   105                                                      
REMARK 465     GLY t   106                                                      
REMARK 465     ILE t   107                                                      
REMARK 465     LYS t   108                                                      
REMARK 465     LEU t   109                                                      
REMARK 465     PRO t   110                                                      
REMARK 465     SER t   111                                                      
REMARK 465     SER t   112                                                      
REMARK 465     VAL t   113                                                      
REMARK 465     PHE t   114                                                      
REMARK 465     ALA t   115                                                      
REMARK 465     SER t   116                                                      
REMARK 465     GLU t   117                                                      
REMARK 465     PHE t   118                                                      
REMARK 465     GLU t   119                                                      
REMARK 465     GLU t   120                                                      
REMARK 465     ASP t   121                                                      
REMARK 465     VAL t   122                                                      
REMARK 465     GLY t   123                                                      
REMARK 465     LEU t   124                                                      
REMARK 465     LEU t   125                                                      
REMARK 465     ASN t   126                                                      
REMARK 465     LYS t   127                                                      
REMARK 465     ALA t   128                                                      
REMARK 465     ALA t   129                                                      
REMARK 465     PRO t   130                                                      
REMARK 465     VAL t   131                                                      
REMARK 465     SER t   132                                                      
REMARK 465     GLY t   133                                                      
REMARK 465     PRO t   134                                                      
REMARK 465     ARG t   135                                                      
REMARK 465     LEU t   136                                                      
REMARK 465     ASP t   137                                                      
REMARK 465     PHE t   138                                                      
REMARK 465     ASP t   139                                                      
REMARK 465     PRO t   140                                                      
REMARK 465     ASP t   141                                                      
REMARK 465     ILE t   142                                                      
REMARK 465     VAL t   143                                                      
REMARK 465     ALA t   144                                                      
REMARK 465     ALA t   145                                                      
REMARK 465     LEU t   146                                                      
REMARK 465     ASP t   147                                                      
REMARK 465     ASP t   148                                                      
REMARK 465     ASP t   149                                                      
REMARK 465     PHE t   150                                                      
REMARK 465     ASP t   151                                                      
REMARK 465     PHE t   152                                                      
REMARK 465     ASP t   153                                                      
REMARK 465     ASP t   154                                                      
REMARK 465     PRO t   155                                                      
REMARK 465     ASP t   156                                                      
REMARK 465     ASN t   157                                                      
REMARK 465     LEU t   158                                                      
REMARK 465     LEU t   159                                                      
REMARK 465     GLU t   160                                                      
REMARK 465     ASP t   161                                                      
REMARK 465     ASP t   162                                                      
REMARK 465     PHE t   163                                                      
REMARK 465     ILE t   164                                                      
REMARK 465     LEU t   165                                                      
REMARK 465     GLN t   166                                                      
REMARK 465     ALA t   167                                                      
REMARK 465     ASN t   168                                                      
REMARK 465     LYS t   169                                                      
REMARK 465     ALA t   170                                                      
REMARK 465     THR t   171                                                      
REMARK 465     GLY t   172                                                      
REMARK 465     GLU t   173                                                      
REMARK 465     GLU t   174                                                      
REMARK 465     GLU t   175                                                      
REMARK 465     GLY t   176                                                      
REMARK 465     MET t   177                                                      
REMARK 465     ASP t   178                                                      
REMARK 465     ILE t   179                                                      
REMARK 465     GLN t   180                                                      
REMARK 465     LYS t   181                                                      
REMARK 465     SER t   182                                                      
REMARK 465     GLU t   183                                                      
REMARK 465     ASN t   184                                                      
REMARK 465     GLU t   185                                                      
REMARK 465     ASP t   186                                                      
REMARK 465     ASP t   187                                                      
REMARK 465     SER t   188                                                      
REMARK 465     GLU t   189                                                      
REMARK 465     TRP t   190                                                      
REMARK 465     GLU t   191                                                      
REMARK 465     ASP t   192                                                      
REMARK 465     VAL t   193                                                      
REMARK 465     ASP t   194                                                      
REMARK 465     ASP t   195                                                      
REMARK 465     GLU t   196                                                      
REMARK 465     LYS t   197                                                      
REMARK 465     GLY t   198                                                      
REMARK 465     ASP t   199                                                      
REMARK 465     SER t   200                                                      
REMARK 465     ASN t   201                                                      
REMARK 465     ASP t   202                                                      
REMARK 465     ASP t   203                                                      
REMARK 465     TYR t   204                                                      
REMARK 465     ASP t   205                                                      
REMARK 465     SER t   206                                                      
REMARK 465     ALA t   207                                                      
REMARK 465     GLY t   208                                                      
REMARK 465     LEU t   209                                                      
REMARK 465     LEU t   210                                                      
REMARK 465     SER t   211                                                      
REMARK 465     ASP t   212                                                      
REMARK 465     GLU t   213                                                      
REMARK 465     ASP t   214                                                      
REMARK 465     CYS t   215                                                      
REMARK 465     MET t   216                                                      
REMARK 465     SER t   217                                                      
REMARK 465     VAL t   218                                                      
REMARK 465     PRO t   219                                                      
REMARK 465     GLY t   220                                                      
REMARK 465     LYS t   221                                                      
REMARK 465     THR t   222                                                      
REMARK 465     HIS t   223                                                      
REMARK 465     ARG t   224                                                      
REMARK 465     ALA t   225                                                      
REMARK 465     ILE t   226                                                      
REMARK 465     ALA t   227                                                      
REMARK 465     ASP t   228                                                      
REMARK 465     HIS t   229                                                      
REMARK 465     LEU t   230                                                      
REMARK 465     PHE t   231                                                      
REMARK 465     TRP t   232                                                      
REMARK 465     SER t   233                                                      
REMARK 465     GLU t   234                                                      
REMARK 465     GLU t   235                                                      
REMARK 465     THR t   236                                                      
REMARK 465     LYS t   237                                                      
REMARK 465     SER t   238                                                      
REMARK 465     ARG t   239                                                      
REMARK 465     PHE t   240                                                      
REMARK 465     THR t   241                                                      
REMARK 465     GLU t   242                                                      
REMARK 465     TYR t   243                                                      
REMARK 465     SER t   244                                                      
REMARK 465     MET t   245                                                      
REMARK 465     THR t   246                                                      
REMARK 465     ASP t   271                                                      
REMARK 465     ASP t   272                                                      
REMARK 465     ASP t   273                                                      
REMARK 465     GLU t   274                                                      
REMARK 465     ILE t   275                                                      
REMARK 465     GLY t   276                                                      
REMARK 465     ALA t   277                                                      
REMARK 465     LEU t   278                                                      
REMARK 465     ASP t   279                                                      
REMARK 465     ASN t   280                                                      
REMARK 465     ALA t   281                                                      
REMARK 465     GLU t   282                                                      
REMARK 465     LEU t   283                                                      
REMARK 465     GLU t   284                                                      
REMARK 465     GLY t   285                                                      
REMARK 465     SER t   286                                                      
REMARK 465     ILE t   287                                                      
REMARK 465     GLN t   288                                                      
REMARK 465     VAL t   289                                                      
REMARK 465     ASP t   290                                                      
REMARK 465     LEU t   315                                                      
REMARK 465     GLU t   316                                                      
REMARK 465     PRO t   317                                                      
REMARK 465     LEU t   318                                                      
REMARK 465     GLU t   319                                                      
REMARK 465     ASP t   320                                                      
REMARK 465     GLN t   321                                                      
REMARK 465     ASP t   322                                                      
REMARK 465     LEU t   323                                                      
REMARK 465     PRO t   324                                                      
REMARK 465     MET t   325                                                      
REMARK 465     ASN t   326                                                      
REMARK 465     GLU t   327                                                      
REMARK 465     LEU t   328                                                      
REMARK 465     ASP t   329                                                      
REMARK 465     GLU t   330                                                      
REMARK 465     SER t   331                                                      
REMARK 465     GLU t   332                                                      
REMARK 465     GLU t   333                                                      
REMARK 465     GLU t   334                                                      
REMARK 465     GLU t   335                                                      
REMARK 465     MET t   336                                                      
REMARK 465     ILE t   337                                                      
REMARK 465     THR t   338                                                      
REMARK 465     VAL t   339                                                      
REMARK 465     VAL t   340                                                      
REMARK 465     LEU t   341                                                      
REMARK 465     GLU t   342                                                      
REMARK 465     GLU t   343                                                      
REMARK 465     ALA t   344                                                      
REMARK 465     LYS t   345                                                      
REMARK 465     GLU t   346                                                      
REMARK 465     LYS t   347                                                      
REMARK 465     TRP t   348                                                      
REMARK 465     ASP t   349                                                      
REMARK 465     CYS t   350                                                      
REMARK 465     GLU t   351                                                      
REMARK 465     GLN t   370                                                      
REMARK 465     PRO t   371                                                      
REMARK 465     LYS t   372                                                      
REMARK 465     PRO t   373                                                      
REMARK 465     LYS t   374                                                      
REMARK 465     GLN t   375                                                      
REMARK 465     ILE t   376                                                      
REMARK 465     ARG t   377                                                      
REMARK 465     ILE t   378                                                      
REMARK 465     SER t   379                                                      
REMARK 465     SER t   380                                                      
REMARK 465     LYS t   381                                                      
REMARK 465     THR t   382                                                      
REMARK 465     GLY t   383                                                      
REMARK 465     ILE t   384                                                      
REMARK 465     PRO t   385                                                      
REMARK 465     LEU t   386                                                      
REMARK 465     ASN t   387                                                      
REMARK 465     VAL t   388                                                      
REMARK 465     LEU t   389                                                      
REMARK 465     PRO t   390                                                      
REMARK 465     LYS t   391                                                      
REMARK 465     LYS t   392                                                      
REMARK 465     GLY t   393                                                      
REMARK 465     LEU t   394                                                      
REMARK 465     THR t   395                                                      
REMARK 465     ALA t   396                                                      
REMARK 465     LYS t   397                                                      
REMARK 465     GLN t   398                                                      
REMARK 465     THR t   399                                                      
REMARK 465     GLU t   400                                                      
REMARK 465     ARG t   401                                                      
REMARK 465     ILE t   402                                                      
REMARK 465     GLN t   403                                                      
REMARK 465     MET t   404                                                      
REMARK 465     ILE t   405                                                      
REMARK 465     ASN t   406                                                      
REMARK 465     GLY t   407                                                      
REMARK 465     SER t   408                                                      
REMARK 465     ASP t   409                                                      
REMARK 465     LEU t   410                                                      
REMARK 465     PRO t   411                                                      
REMARK 465     LYS t   412                                                      
REMARK 465     VAL t   413                                                      
REMARK 465     LEU t   475                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470       C 21698    P    OP1  OP2                                       
REMARK 470     THR R  55    OG1  CG2                                            
REMARK 470     GLU c  62    CG   CD   OE1  OE2                                  
REMARK 470     GLU c  64    CG   CD   OE1  OE2                                  
REMARK 470     GLU x  73    CG   CD   OE1  OE2                                  
REMARK 470     GLU x 164    CG   CD   OE1  OE2                                  
REMARK 470     ASP x 174    CG   OD1  OD2                                       
REMARK 470     ARG y 412    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU u  47    CG   CD   OE1  OE2                                  
REMARK 470     ASP u  52    CG   OD1  OD2                                       
REMARK 470     LYS u 392    CG   CD   CE   NZ                                   
REMARK 470     GLU u 546    CG   CD   OE1  OE2                                  
REMARK 470     GLU u 548    CG   CD   OE1  OE2                                  
REMARK 470     GLU u 550    CG   CD   OE1  OE2                                  
REMARK 470     GLU u 785    CG   CD   OE1  OE2                                  
REMARK 470     ASN v 527    CG   OD1  ND2                                       
REMARK 470     ILE v 528    CG1  CG2  CD1                                       
REMARK 470     PHE v 529    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR v 530    OG1  CG2                                            
REMARK 470     LYS v 531    CG   CD   CE   NZ                                   
REMARK 470     GLN v 532    CG   CD   OE1  NE2                                  
REMARK 470     ARG v 533    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG v 534    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU v 535    CG   CD   OE1  OE2                                  
REMARK 470     ASN v 536    CG   OD1  ND2                                       
REMARK 470     MET v 537    CG   SD   CE                                        
REMARK 470     GLN v 538    CG   CD   OE1  NE2                                  
REMARK 470     ASN v 539    CG   OD1  ND2                                       
REMARK 470     ILE v 540    CG1  CG2  CD1                                       
REMARK 470     LYS v 541    CG   CD   CE   NZ                                   
REMARK 470     SER v 542    OG                                                  
REMARK 470     SER v 543    OG                                                  
REMARK 470     LEU v 544    CG   CD1  CD2                                       
REMARK 470     SER t 352    OG                                                  
REMARK 470     ILE t 353    CG1  CG2  CD1                                       
REMARK 470     CYS t 354    SG                                                  
REMARK 470     SER t 355    OG                                                  
REMARK 470     THR t 356    OG1  CG2                                            
REMARK 470     TYR t 357    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER t 358    OG                                                  
REMARK 470     ASN t 359    CG   OD1  ND2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   N3     U 2     8     N6     A 2  1196              1.43            
REMARK 500   N6     A 2   830     N3     U 2   844              1.65            
REMARK 500   N1     A 2   872     O4     U 2   914              1.82            
REMARK 500   N6     A 2   872     N3     U 2   914              1.83            
REMARK 500   C2     U 2     8     N6     A 2  1196              1.98            
REMARK 500   N1     A 2   830     O4     U 2   844              2.04            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500      A 2 604   C2' -  C3' -  O3' ANGL. DEV. =  10.7 DEGREES          
REMARK 500      G 2 958   C2' -  C3' -  O3' ANGL. DEV. =  10.5 DEGREES          
REMARK 500      A 2 980   C2' -  C3' -  O3' ANGL. DEV. =  10.4 DEGREES          
REMARK 500      C 21231   C2' -  C3' -  O3' ANGL. DEV. =  10.6 DEGREES          
REMARK 500      G 21431   C2' -  C3' -  O3' ANGL. DEV. =   9.7 DEGREES          
REMARK 500      U 21494   C2' -  C3' -  O3' ANGL. DEV. =  12.5 DEGREES          
REMARK 500      U 21511   C2' -  C3' -  O3' ANGL. DEV. =  11.3 DEGREES          
REMARK 500      G 21726   C2' -  C3' -  O3' ANGL. DEV. =  10.0 DEGREES          
REMARK 500    TYR t 357   CB  -  CA  -  C   ANGL. DEV. = -20.7 DEGREES          
REMARK 500    TYR t 357   N   -  CA  -  C   ANGL. DEV. = -27.2 DEGREES          
REMARK 500    SER t 358   N   -  CA  -  CB  ANGL. DEV. =  -9.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    PHE F  20        5.43     59.12                                   
REMARK 500    LYS F  22      -23.53   -152.16                                   
REMARK 500    VAL F  41      -15.51   -153.60                                   
REMARK 500    GLU F  43      -70.42   -129.10                                   
REMARK 500    PHE F 163      -71.52    -71.84                                   
REMARK 500    ARG F 164       73.77   -116.43                                   
REMARK 500    SER F 185       43.74    -95.30                                   
REMARK 500    ASN M  15       38.39    -93.94                                   
REMARK 500    THR M  16      -39.55   -141.79                                   
REMARK 500    ILE M  35      -51.27   -134.77                                   
REMARK 500    ARG M  45       31.38     39.59                                   
REMARK 500    LYS M 116       90.12    -67.92                                   
REMARK 500    MET P  34       20.51    -65.32                                   
REMARK 500    GLN P  35      -12.94   -148.26                                   
REMARK 500    GLU P  66       56.18    -96.29                                   
REMARK 500    LEU P  80       96.43    -68.66                                   
REMARK 500    LYS P 100      -41.55   -134.89                                   
REMARK 500    MET P 111       33.66    -99.40                                   
REMARK 500    LYS Q  17     -101.34     61.43                                   
REMARK 500    TYR R  20       58.42   -117.65                                   
REMARK 500    ILE R  38      -60.16   -100.80                                   
REMARK 500    LEU R 108       20.92    -78.39                                   
REMARK 500    ASP R 110       -7.65     91.90                                   
REMARK 500    PHE R 111       51.02    -92.95                                   
REMARK 500    SER R 113       31.24    -96.78                                   
REMARK 500    PRO R 122       95.59    -68.48                                   
REMARK 500    TRP S  82      -23.97   -160.94                                   
REMARK 500    GLN S  87      -98.95    -82.95                                   
REMARK 500    LYS S  91      -72.75    -75.26                                   
REMARK 500    LEU S  99     -133.56   -112.92                                   
REMARK 500    ALA S 100      -70.59    -81.07                                   
REMARK 500    THR T  36      -36.18   -132.58                                   
REMARK 500    LYS T  38     -150.00    -82.88                                   
REMARK 500    LEU T  39       -4.21   -143.32                                   
REMARK 500    ASN T  51       42.29   -108.07                                   
REMARK 500    ASN T  85       23.79    -76.36                                   
REMARK 500    LYS T 122     -161.98   -120.89                                   
REMARK 500    ASN T 142      -46.12   -130.10                                   
REMARK 500    PRO Z  63       30.67    -73.32                                   
REMARK 500    ASN Z  64       54.82   -151.98                                   
REMARK 500    LYS Z  66      -66.54     68.99                                   
REMARK 500    VAL Z 100      -63.28    -96.47                                   
REMARK 500    LEU c  18      -70.11    -83.91                                   
REMARK 500    ASP c  37      -29.25     71.59                                   
REMARK 500    SER c  39       31.47    -85.68                                   
REMARK 500    ARG c  66       87.54    -48.03                                   
REMARK 500    LYS f  82      112.87     71.75                                   
REMARK 500    SER f  84     -103.85    -78.72                                   
REMARK 500    TYR f  85      124.23     63.84                                   
REMARK 500    LEU f 100       80.25     57.57                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     219 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN f 200  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS f 141   O                                                      
REMARK 620 2 LYS f 143   N    98.4                                              
REMARK 620 3 CYS f 144   N   135.8  67.4                                        
REMARK 620 4 CYS f 145   N   113.2 134.2  66.8                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN y 500  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS y 270   SG                                                     
REMARK 620 2 CYS y 273   SG  100.5                                              
REMARK 620 3 CYS y 285   SG  107.4 146.6                                        
REMARK 620 4 CYS y 288   SG   96.2 109.7  85.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN f 200                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN y 500                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-4337   RELATED DB: EMDB                              
REMARK 900 CRYO-EM STRUCTURE OF A LATE HUMAN PRE-40S RIBOSOMAL SUBUNIT - STATE  
REMARK 900 C                                                                    
DBREF1 6G18 2    1  1873  GB                   AL353644.34                      
DBREF2 6G18 2     151415227                      125931      127803             
DBREF  6G18 F    1   204  UNP    P46782   RS5_HUMAN        1    204             
DBREF  6G18 M    1   132  UNP    P25398   RS12_HUMAN       1    132             
DBREF  6G18 P    1   145  UNP    P62841   RS15_HUMAN       1    145             
DBREF  6G18 Q    1   146  UNP    P62249   RS16_HUMAN       1    146             
DBREF  6G18 R    1   135  UNP    P08708   RS17_HUMAN       1    135             
DBREF  6G18 S    1   152  UNP    P62269   RS18_HUMAN       1    152             
DBREF  6G18 T    1   145  UNP    P39019   RS19_HUMAN       1    145             
DBREF  6G18 Z    1   125  UNP    P62851   RS25_HUMAN       1    125             
DBREF  6G18 c    1    69  UNP    P62857   RS28_HUMAN       1     69             
DBREF  6G18 f    1   156  UNP    P62979   RS27A_HUMAN      1    156             
DBREF  6G18 g    1   317  UNP    P63244   RACK1_HUMAN      1    317             
DBREF  6G18 A    1   295  UNP    P08865   RSSA_HUMAN       1    295             
DBREF  6G18 B    1   264  UNP    P61247   RS3A_HUMAN       1    264             
DBREF  6G18 C    1   293  UNP    P15880   RS2_HUMAN        1    293             
DBREF  6G18 E    1   263  UNP    P62701   RS4X_HUMAN       1    263             
DBREF  6G18 G    1   249  UNP    P62753   RS6_HUMAN        1    249             
DBREF  6G18 H    1   194  UNP    P62081   RS7_HUMAN        1    194             
DBREF  6G18 I    1   208  UNP    P62241   RS8_HUMAN        1    208             
DBREF  6G18 J    1   194  UNP    P46781   RS9_HUMAN        1    194             
DBREF  6G18 L    1   158  UNP    P62280   RS11_HUMAN       1    158             
DBREF  6G18 N    1   151  UNP    P62277   RS13_HUMAN       1    151             
DBREF  6G18 O    1   151  UNP    P62263   RS14_HUMAN       1    151             
DBREF  6G18 V    1    83  UNP    P63220   RS21_HUMAN       1     83             
DBREF  6G18 W    1   130  UNP    P62244   RS15A_HUMAN      1    130             
DBREF  6G18 X    1   143  UNP    P62266   RS23_HUMAN       1    143             
DBREF  6G18 Y    1   133  UNP    P62847   RS24_HUMAN       1    133             
DBREF  6G18 b    1    84  UNP    P42677   RS27_HUMAN       1     84             
DBREF  6G18 e    1    59  UNP    P62861   RS30_HUMAN       1     59             
DBREF  6G18 x    1   252  UNP    Q9NRX1   PNO1_HUMAN       1    252             
DBREF  6G18 y    1   412  UNP    Q9ULX3   NOB1_HUMAN       1    412             
DBREF  6G18 u    1   804  UNP    Q2NL82   TSR1_HUMAN       1    804             
DBREF  6G18 w    1   437  UNP    Q13895   BYST_HUMAN       1    437             
DBREF  6G18 v    1   552  UNP    Q9BVS4   RIOK2_HUMAN      1    552             
DBREF  6G18 t    1   475  UNP    Q96GA3   LTV1_HUMAN       1    475             
SEQRES   1 2 1873    U   A   C   C   U   G   G   U   U   G   A   U   C          
SEQRES   2 2 1873    C   U   G   C   C   A   G   U   A   G   C   A   U          
SEQRES   3 2 1873    A   U   G   C   U   U   G   U   C   U   C   A   A          
SEQRES   4 2 1873    A   G   A   U   U   A   A   G   C   C   A   U   G          
SEQRES   5 2 1873    C   A   U   G   U   C   U   A   A   G   U   A   C          
SEQRES   6 2 1873    G   C   A   C   G   G   C   C   G   G   U   A   C          
SEQRES   7 2 1873    A   G   U   G   A   A   A   C   U   G   C   G   A          
SEQRES   8 2 1873    A   U   G   G   C   U   C   A   U   U   A   A   A          
SEQRES   9 2 1873    U   C   A   G   U   U   A   U   G   G   U   U   C          
SEQRES  10 2 1873    C   U   U   U   G   G   U   C   G   C   U   C   G          
SEQRES  11 2 1873    C   U   C   C   U   C   U   C   C   U   A   C   U          
SEQRES  12 2 1873    U   G   G   A   U   A   A   C   U   G   U   G   G          
SEQRES  13 2 1873    U   A   A   U   U   C   U   A   G   A   G   C   U          
SEQRES  14 2 1873    A   A   U   A   C   A   U   G   C   C   G   A   C          
SEQRES  15 2 1873    G   G   G   C   G   C   U   G   A   C   C   C   C          
SEQRES  16 2 1873    C   U   U   C   G   C   G   G   G   G   G   G   G          
SEQRES  17 2 1873    A   U   G   C   G   U   G   C   A   U   U   U   A          
SEQRES  18 2 1873    U   C   A   G   A   U   C   A   A   A   A   C   C          
SEQRES  19 2 1873    A   A   C   C   C   G   G   U   C   A   G   C   C          
SEQRES  20 2 1873    C   C   U   C   U   C   C   G   G   C   C   C   C          
SEQRES  21 2 1873    G   G   C   C   G   G   G   G   G   G   C   G   G          
SEQRES  22 2 1873    G   C   G   C   C   G   G   C   G   G   C   U   U          
SEQRES  23 2 1873    U   G   G   U   G   A   C   U   C   U   A   G   A          
SEQRES  24 2 1873    U   A   A   C   C   U   C   G   G   G   C   C   G          
SEQRES  25 2 1873    A   U   C   G   C   A   C   G   C   C   C   C   C          
SEQRES  26 2 1873    C   G   U   G   G   C   G   G   C   G   A   C   G          
SEQRES  27 2 1873    A   C   C   C   A   U   U   C   G   A   A   C   G          
SEQRES  28 2 1873    U   C   U   G   C   C   C   U   A   U   C   A   A          
SEQRES  29 2 1873    C   U   U   U   C   G   A   U   G   G   U   A   G          
SEQRES  30 2 1873    U   C   G   C   C   G   U   G   C   C   U   A   C          
SEQRES  31 2 1873    C   A   U   G   G   U   G   A   C   C   A   C   G          
SEQRES  32 2 1873    G   G   U   G   A   C   G   G   G   G   A   A   U          
SEQRES  33 2 1873    C   A   G   G   G   U   U   C   G   A   U   U   C          
SEQRES  34 2 1873    C   G   G   A   G   A   G   G   G   A   G   C   C          
SEQRES  35 2 1873    U   G   A   G   A   A   A   C   G   G   C   U   A          
SEQRES  36 2 1873    C   C   A   C   A   U   C   C   A   A   G   G   A          
SEQRES  37 2 1873    A   G   G   C   A   G   C   A   G   G   C   G   C          
SEQRES  38 2 1873    G   C   A   A   A   U   U   A   C   C   C   A   C          
SEQRES  39 2 1873    U   C   C   C   G   A   C   C   C   G   G   G   G          
SEQRES  40 2 1873    A   G   G   U   A   G   U   G   A   C   G   A   A          
SEQRES  41 2 1873    A   A   A   U   A   A   C   A   A   U   A   C   A          
SEQRES  42 2 1873    G   G   A   C   U   C   U   U   U   C   G   A   G          
SEQRES  43 2 1873    G   C   C   C   U   G   U   A   A   U   U   G   G          
SEQRES  44 2 1873    A   A   U   G   A   G   U   C   C   A   C   U   U          
SEQRES  45 2 1873    U   A   A   A   U   C   C   U   U   U   A   A   C          
SEQRES  46 2 1873    G   A   G   G   A   U   C   C   A   U   U   G   G          
SEQRES  47 2 1873    A   G   G   G   C   A   A   G   U   C   U   G   G          
SEQRES  48 2 1873    U   G   C   C   A   G   C   A   G   C   C   G   C          
SEQRES  49 2 1873    G   G   U   A   A   U   U   C   C   A   G   C   U          
SEQRES  50 2 1873    C   C   A   A   U   A   G   C   G   U   A   U   A          
SEQRES  51 2 1873    U   U   A   A   A   G   U   U   G   C   U   G   C          
SEQRES  52 2 1873    A   G   U   U   A   A   A   A   A   G   C   U   C          
SEQRES  53 2 1873    G   U   A   G   U   U   G   G   A   U   C   U   U          
SEQRES  54 2 1873    G   G   G   A   G   C   G   G   G   C   G   G   G          
SEQRES  55 2 1873    C   G   G   U   C   C   G   C   C   G   C   G   A          
SEQRES  56 2 1873    G   G   C   G   A   G   C   C   A   C   C   G   C          
SEQRES  57 2 1873    C   C   G   U   C   C   C   C   G   C   C   C   C          
SEQRES  58 2 1873    U   U   G   C   C   U   C   U   C   G   G   C   G          
SEQRES  59 2 1873    C   C   C   C   C   U   C   G   A   U   G   C   U          
SEQRES  60 2 1873    C   U   U   A   G   C   U   G   A   G   U   G   U          
SEQRES  61 2 1873    C   C   C   G   C   G   G   G   G   C   C   C   G          
SEQRES  62 2 1873    A   A   G   C   G   U   U   U   A   C   U   U   U          
SEQRES  63 2 1873    G   A   A   A   A   A   A   U   U   A   G   A   G          
SEQRES  64 2 1873    U   G   U   U   C   A   A   A   G   C   A   G   G          
SEQRES  65 2 1873    C   C   C   G   A   G   C   C   G   C   C   U   G          
SEQRES  66 2 1873    G   A   U   A   C   C   G   C   A   G   C   U   A          
SEQRES  67 2 1873    G   G   A   A   U   A   A   U   G   G   A   A   U          
SEQRES  68 2 1873    A   G   G   A   C   C   G   C   G   G   U   U   C          
SEQRES  69 2 1873    U   A   U   U   U   U   G   U   U   G   G   U   U          
SEQRES  70 2 1873    U   U   C   G   G   A   A   C   U   G   A   G   G          
SEQRES  71 2 1873    C   C   A   U   G   A   U   U   A   A   G   A   G          
SEQRES  72 2 1873    G   G   A   C   G   G   C   C   G   G   G   G   G          
SEQRES  73 2 1873    C   A   U   U   C   G   U   A   U   U   G   C   G          
SEQRES  74 2 1873    C   C   G   C   U   A   G   A   G   G   U   G   A          
SEQRES  75 2 1873    A   A   U   U   C   U   U   G   G   A   C   C   G          
SEQRES  76 2 1873    G   C   G   C   A   A   G   A   C   G   G   A   C          
SEQRES  77 2 1873    C   A   G   A   G   C   G   A   A   A   G   C   A          
SEQRES  78 2 1873    U   U   U   G   C   C   A   A   G   A   A   U   G          
SEQRES  79 2 1873    U   U   U   U   C   A   U   U   A   A   U   C   A          
SEQRES  80 2 1873    A   G   A   A   C   G   A   A   A   G   U   C   G          
SEQRES  81 2 1873    G   A   G   G   U   U   C   G   A   A   G   A   C          
SEQRES  82 2 1873    G   A   U   C   A   G   A   U   A   C   C   G   U          
SEQRES  83 2 1873    C   G   U   A   G   U   U   C   C   G   A   C   C          
SEQRES  84 2 1873    A   U   A   A   A   C   G   A   U   G   C   C   G          
SEQRES  85 2 1873    A   C   C   G   G   C   G   A   U   G   C   G   G          
SEQRES  86 2 1873    C   G   G   C   G   U   U   A   U   U   C   C   C          
SEQRES  87 2 1873    A   U   G   A   C   C   C   G   C   C   G   G   G          
SEQRES  88 2 1873    C   A   G   C   U   U   C   C   G   G   G   A   A          
SEQRES  89 2 1873    A   C   C   A   A   A   G   U   C   U   U   U   G          
SEQRES  90 2 1873    G   G   U   U   C   C   G   G   G   G   G   G   A          
SEQRES  91 2 1873    G   U   A   U   G   G   U   U   G   C   A   A   A          
SEQRES  92 2 1873    G   C   U   G   A   A   A   C   U   U   A   A   A          
SEQRES  93 2 1873    G   G   A   A   U   U   G   A   C   G   G   A   A          
SEQRES  94 2 1873    G   G   G   C   A   C   C   A   C   C   A   G   G          
SEQRES  95 2 1873    A   G   U   G   G   A   G   C   C   U   G   C   G          
SEQRES  96 2 1873    G   C   U   U   A   A   U   U   U   G   A   C   U          
SEQRES  97 2 1873    C   A   A   C   A   C   G   G   G   A   A   A   C          
SEQRES  98 2 1873    C   U   C   A   C   C   C   G   G   C   C   C   G          
SEQRES  99 2 1873    G   A   C   A   C   G   G   A   C   A   G   G   A          
SEQRES 100 2 1873    U   U   G   A   C   A   G   A   U   U   G   A   U          
SEQRES 101 2 1873    A   G   C   U   C   U   U   U   C   U   C   G   A          
SEQRES 102 2 1873    U   U   C   C   G   U   G   G   G   U   G   G   U          
SEQRES 103 2 1873    G   G   U   G   C   A   U   G   G   C   C   G   U          
SEQRES 104 2 1873    U   C   U   U   A   G   U   U   G   G   U   G   G          
SEQRES 105 2 1873    A   G   C   G   A   U   U   U   G   U   C   U   G          
SEQRES 106 2 1873    G   U   U   A   A   U   U   C   C   G   A   U   A          
SEQRES 107 2 1873    A   C   G   A   A   C   G   A   G   A   C   U   C          
SEQRES 108 2 1873    U   G   G   C   A   U   G   C   U   A   A   C   U          
SEQRES 109 2 1873    A   G   U   U   A   C   G   C   G   A   C   C   C          
SEQRES 110 2 1873    C   C   G   A   G   C   G   G   U   C   G   G   C          
SEQRES 111 2 1873    G   U   C   C   C   C   C   A   A   C   U   U   C          
SEQRES 112 2 1873    U   U   A   G   A   G   G   G   A   C   A   A   G          
SEQRES 113 2 1873    U   G   G   C   G   U   U   C   A   G   C   C   A          
SEQRES 114 2 1873    C   C   C   G   A   G   A   U   U   G   A   G   C          
SEQRES 115 2 1873    A   A   U   A   A   C   A   G   G   U   C   U   G          
SEQRES 116 2 1873    U   G   A   U   G   C   C   C   U   U   A   G   A          
SEQRES 117 2 1873    U   G   U   C   C   G   G   G   G   C   U   G   C          
SEQRES 118 2 1873    A   C   G   C   G   C   G   C   U   A   C   A   C          
SEQRES 119 2 1873    U   G   A   C   U   G   G   C   U   C   A   G   C          
SEQRES 120 2 1873    G   U   G   U   G   C   C   U   A   C   C   C   U          
SEQRES 121 2 1873    A   C   G   C   C   G   G   C   A   G   G   C   G          
SEQRES 122 2 1873    C   G   G   G   U   A   A   C   C   C   G   U   U          
SEQRES 123 2 1873    G   A   A   C   C   C   C   A   U   U   C   G   U          
SEQRES 124 2 1873    G   A   U   G   G   G   G   A   U   C   G   G   G          
SEQRES 125 2 1873    G   A   U   U   G   C   A   A   U   U   A   U   U          
SEQRES 126 2 1873    C   C   C   C   A   U   G   A   A   C   G   A   G          
SEQRES 127 2 1873    G   A   A   U   U   C   C   C   A   G   U   A   A          
SEQRES 128 2 1873    G   U   G   C   G   G   G   U   C   A   U   A   A          
SEQRES 129 2 1873    G   C   U   U   G   C   G   U   U   G   A   U   U          
SEQRES 130 2 1873    A   A   G   U   C   C   C   U   G   C   C   C   U          
SEQRES 131 2 1873    U   U   G   U   A   C   A   C   A   C   C   G   C          
SEQRES 132 2 1873    C   C   G   U   C   G   C   U   A   C   U   A   C          
SEQRES 133 2 1873    C   G   A   U   U   G   G   A   U   G   G   U   U          
SEQRES 134 2 1873    U   A   G   U   G   A   G   G   C   C   C   U   C          
SEQRES 135 2 1873    G   G   A   U   C   G   G   C   C   C   C   G   C          
SEQRES 136 2 1873    C   G   G   G   G   U   C   G   G   C   C   C   A          
SEQRES 137 2 1873    C   G   G   C   C   C   U   G   G   C   G   G   A          
SEQRES 138 2 1873    G   C   G   C   U   G   A   G   A   A   G   A   C          
SEQRES 139 2 1873    G   G   U   C   G   A   A   C   U   U   G   A   C          
SEQRES 140 2 1873    U   A   U   C   U   A   G   A   G   G   A   A   G          
SEQRES 141 2 1873    U   A   A   A   A   G   U   C   G   U   A   A   C          
SEQRES 142 2 1873    A   A   G   G   U   U   U   C   C   G   U   A   G          
SEQRES 143 2 1873    G   U   G   A   A   C   C   U   G   C   G   G   A          
SEQRES 144 2 1873    A   G   G   A   U   C   A   U   U   A   A   C   G          
SEQRES 145 2 1873    G                                                          
SEQRES   1 F  204  MET THR GLU TRP GLU THR ALA ALA PRO ALA VAL ALA GLU          
SEQRES   2 F  204  THR PRO ASP ILE LYS LEU PHE GLY LYS TRP SER THR ASP          
SEQRES   3 F  204  ASP VAL GLN ILE ASN ASP ILE SER LEU GLN ASP TYR ILE          
SEQRES   4 F  204  ALA VAL LYS GLU LYS TYR ALA LYS TYR LEU PRO HIS SER          
SEQRES   5 F  204  ALA GLY ARG TYR ALA ALA LYS ARG PHE ARG LYS ALA GLN          
SEQRES   6 F  204  CYS PRO ILE VAL GLU ARG LEU THR ASN SER MET MET MET          
SEQRES   7 F  204  HIS GLY ARG ASN ASN GLY LYS LYS LEU MET THR VAL ARG          
SEQRES   8 F  204  ILE VAL LYS HIS ALA PHE GLU ILE ILE HIS LEU LEU THR          
SEQRES   9 F  204  GLY GLU ASN PRO LEU GLN VAL LEU VAL ASN ALA ILE ILE          
SEQRES  10 F  204  ASN SER GLY PRO ARG GLU ASP SER THR ARG ILE GLY ARG          
SEQRES  11 F  204  ALA GLY THR VAL ARG ARG GLN ALA VAL ASP VAL SER PRO          
SEQRES  12 F  204  LEU ARG ARG VAL ASN GLN ALA ILE TRP LEU LEU CYS THR          
SEQRES  13 F  204  GLY ALA ARG GLU ALA ALA PHE ARG ASN ILE LYS THR ILE          
SEQRES  14 F  204  ALA GLU CYS LEU ALA ASP GLU LEU ILE ASN ALA ALA LYS          
SEQRES  15 F  204  GLY SER SER ASN SER TYR ALA ILE LYS LYS LYS ASP GLU          
SEQRES  16 F  204  LEU GLU ARG VAL ALA LYS SER ASN ARG                          
SEQRES   1 M  132  MET ALA GLU GLU GLY ILE ALA ALA GLY GLY VAL MET ASP          
SEQRES   2 M  132  VAL ASN THR ALA LEU GLN GLU VAL LEU LYS THR ALA LEU          
SEQRES   3 M  132  ILE HIS ASP GLY LEU ALA ARG GLY ILE ARG GLU ALA ALA          
SEQRES   4 M  132  LYS ALA LEU ASP LYS ARG GLN ALA HIS LEU CYS VAL LEU          
SEQRES   5 M  132  ALA SER ASN CYS ASP GLU PRO MET TYR VAL LYS LEU VAL          
SEQRES   6 M  132  GLU ALA LEU CYS ALA GLU HIS GLN ILE ASN LEU ILE LYS          
SEQRES   7 M  132  VAL ASP ASP ASN LYS LYS LEU GLY GLU TRP VAL GLY LEU          
SEQRES   8 M  132  CYS LYS ILE ASP ARG GLU GLY LYS PRO ARG LYS VAL VAL          
SEQRES   9 M  132  GLY CYS SER CYS VAL VAL VAL LYS ASP TYR GLY LYS GLU          
SEQRES  10 M  132  SER GLN ALA LYS ASP VAL ILE GLU GLU TYR PHE LYS CYS          
SEQRES  11 M  132  LYS LYS                                                      
SEQRES   1 P  145  MET ALA GLU VAL GLU GLN LYS LYS LYS ARG THR PHE ARG          
SEQRES   2 P  145  LYS PHE THR TYR ARG GLY VAL ASP LEU ASP GLN LEU LEU          
SEQRES   3 P  145  ASP MET SER TYR GLU GLN LEU MET GLN LEU TYR SER ALA          
SEQRES   4 P  145  ARG GLN ARG ARG ARG LEU ASN ARG GLY LEU ARG ARG LYS          
SEQRES   5 P  145  GLN HIS SER LEU LEU LYS ARG LEU ARG LYS ALA LYS LYS          
SEQRES   6 P  145  GLU ALA PRO PRO MET GLU LYS PRO GLU VAL VAL LYS THR          
SEQRES   7 P  145  HIS LEU ARG ASP MET ILE ILE LEU PRO GLU MET VAL GLY          
SEQRES   8 P  145  SER MET VAL GLY VAL TYR ASN GLY LYS THR PHE ASN GLN          
SEQRES   9 P  145  VAL GLU ILE LYS PRO GLU MET ILE GLY HIS TYR LEU GLY          
SEQRES  10 P  145  GLU PHE SER ILE THR TYR LYS PRO VAL LYS HIS GLY ARG          
SEQRES  11 P  145  PRO GLY ILE GLY ALA THR HIS SER SER ARG PHE ILE PRO          
SEQRES  12 P  145  LEU LYS                                                      
SEQRES   1 Q  146  MET PRO SER LYS GLY PRO LEU GLN SER VAL GLN VAL PHE          
SEQRES   2 Q  146  GLY ARG LYS LYS THR ALA THR ALA VAL ALA HIS CYS LYS          
SEQRES   3 Q  146  ARG GLY ASN GLY LEU ILE LYS VAL ASN GLY ARG PRO LEU          
SEQRES   4 Q  146  GLU MET ILE GLU PRO ARG THR LEU GLN TYR LYS LEU LEU          
SEQRES   5 Q  146  GLU PRO VAL LEU LEU LEU GLY LYS GLU ARG PHE ALA GLY          
SEQRES   6 Q  146  VAL ASP ILE ARG VAL ARG VAL LYS GLY GLY GLY HIS VAL          
SEQRES   7 Q  146  ALA GLN ILE TYR ALA ILE ARG GLN SER ILE SER LYS ALA          
SEQRES   8 Q  146  LEU VAL ALA TYR TYR GLN LYS TYR VAL ASP GLU ALA SER          
SEQRES   9 Q  146  LYS LYS GLU ILE LYS ASP ILE LEU ILE GLN TYR ASP ARG          
SEQRES  10 Q  146  THR LEU LEU VAL ALA ASP PRO ARG ARG CYS GLU SER LYS          
SEQRES  11 Q  146  LYS PHE GLY GLY PRO GLY ALA ARG ALA ARG TYR GLN LYS          
SEQRES  12 Q  146  SER TYR ARG                                                  
SEQRES   1 R  135  MET GLY ARG VAL ARG THR LYS THR VAL LYS LYS ALA ALA          
SEQRES   2 R  135  ARG VAL ILE ILE GLU LYS TYR TYR THR ARG LEU GLY ASN          
SEQRES   3 R  135  ASP PHE HIS THR ASN LYS ARG VAL CYS GLU GLU ILE ALA          
SEQRES   4 R  135  ILE ILE PRO SER LYS LYS LEU ARG ASN LYS ILE ALA GLY          
SEQRES   5 R  135  TYR VAL THR HIS LEU MET LYS ARG ILE GLN ARG GLY PRO          
SEQRES   6 R  135  VAL ARG GLY ILE SER ILE LYS LEU GLN GLU GLU GLU ARG          
SEQRES   7 R  135  GLU ARG ARG ASP ASN TYR VAL PRO GLU VAL SER ALA LEU          
SEQRES   8 R  135  ASP GLN GLU ILE ILE GLU VAL ASP PRO ASP THR LYS GLU          
SEQRES   9 R  135  MET LEU LYS LEU LEU ASP PHE GLY SER LEU SER ASN LEU          
SEQRES  10 R  135  GLN VAL THR GLN PRO THR VAL GLY MET ASN PHE LYS THR          
SEQRES  11 R  135  PRO ARG GLY PRO VAL                                          
SEQRES   1 S  152  MET SER LEU VAL ILE PRO GLU LYS PHE GLN HIS ILE LEU          
SEQRES   2 S  152  ARG VAL LEU ASN THR ASN ILE ASP GLY ARG ARG LYS ILE          
SEQRES   3 S  152  ALA PHE ALA ILE THR ALA ILE LYS GLY VAL GLY ARG ARG          
SEQRES   4 S  152  TYR ALA HIS VAL VAL LEU ARG LYS ALA ASP ILE ASP LEU          
SEQRES   5 S  152  THR LYS ARG ALA GLY GLU LEU THR GLU ASP GLU VAL GLU          
SEQRES   6 S  152  ARG VAL ILE THR ILE MET GLN ASN PRO ARG GLN TYR LYS          
SEQRES   7 S  152  ILE PRO ASP TRP PHE LEU ASN ARG GLN LYS ASP VAL LYS          
SEQRES   8 S  152  ASP GLY LYS TYR SER GLN VAL LEU ALA ASN GLY LEU ASP          
SEQRES   9 S  152  ASN LYS LEU ARG GLU ASP LEU GLU ARG LEU LYS LYS ILE          
SEQRES  10 S  152  ARG ALA HIS ARG GLY LEU ARG HIS PHE TRP GLY LEU ARG          
SEQRES  11 S  152  VAL ARG GLY GLN HIS THR LYS THR THR GLY ARG ARG GLY          
SEQRES  12 S  152  ARG THR VAL GLY VAL SER LYS LYS LYS                          
SEQRES   1 T  145  MET PRO GLY VAL THR VAL LYS ASP VAL ASN GLN GLN GLU          
SEQRES   2 T  145  PHE VAL ARG ALA LEU ALA ALA PHE LEU LYS LYS SER GLY          
SEQRES   3 T  145  LYS LEU LYS VAL PRO GLU TRP VAL ASP THR VAL LYS LEU          
SEQRES   4 T  145  ALA LYS HIS LYS GLU LEU ALA PRO TYR ASP GLU ASN TRP          
SEQRES   5 T  145  PHE TYR THR ARG ALA ALA SER THR ALA ARG HIS LEU TYR          
SEQRES   6 T  145  LEU ARG GLY GLY ALA GLY VAL GLY SER MET THR LYS ILE          
SEQRES   7 T  145  TYR GLY GLY ARG GLN ARG ASN GLY VAL MET PRO SER HIS          
SEQRES   8 T  145  PHE SER ARG GLY SER LYS SER VAL ALA ARG ARG VAL LEU          
SEQRES   9 T  145  GLN ALA LEU GLU GLY LEU LYS MET VAL GLU LYS ASP GLN          
SEQRES  10 T  145  ASP GLY GLY ARG LYS LEU THR PRO GLN GLY GLN ARG ASP          
SEQRES  11 T  145  LEU ASP ARG ILE ALA GLY GLN VAL ALA ALA ALA ASN LYS          
SEQRES  12 T  145  LYS HIS                                                      
SEQRES   1 Z  125  MET PRO PRO LYS ASP ASP LYS LYS LYS LYS ASP ALA GLY          
SEQRES   2 Z  125  LYS SER ALA LYS LYS ASP LYS ASP PRO VAL ASN LYS SER          
SEQRES   3 Z  125  GLY GLY LYS ALA LYS LYS LYS LYS TRP SER LYS GLY LYS          
SEQRES   4 Z  125  VAL ARG ASP LYS LEU ASN ASN LEU VAL LEU PHE ASP LYS          
SEQRES   5 Z  125  ALA THR TYR ASP LYS LEU CYS LYS GLU VAL PRO ASN TYR          
SEQRES   6 Z  125  LYS LEU ILE THR PRO ALA VAL VAL SER GLU ARG LEU LYS          
SEQRES   7 Z  125  ILE ARG GLY SER LEU ALA ARG ALA ALA LEU GLN GLU LEU          
SEQRES   8 Z  125  LEU SER LYS GLY LEU ILE LYS LEU VAL SER LYS HIS ARG          
SEQRES   9 Z  125  ALA GLN VAL ILE TYR THR ARG ASN THR LYS GLY GLY ASP          
SEQRES  10 Z  125  ALA PRO ALA ALA GLY GLU ASP ALA                              
SEQRES   1 c   69  MET ASP THR SER ARG VAL GLN PRO ILE LYS LEU ALA ARG          
SEQRES   2 c   69  VAL THR LYS VAL LEU GLY ARG THR GLY SER GLN GLY GLN          
SEQRES   3 c   69  CYS THR GLN VAL ARG VAL GLU PHE MET ASP ASP THR SER          
SEQRES   4 c   69  ARG SER ILE ILE ARG ASN VAL LYS GLY PRO VAL ARG GLU          
SEQRES   5 c   69  GLY ASP VAL LEU THR LEU LEU GLU SER GLU ARG GLU ALA          
SEQRES   6 c   69  ARG ARG LEU ARG                                              
SEQRES   1 f  156  MET GLN ILE PHE VAL LYS THR LEU THR GLY LYS THR ILE          
SEQRES   2 f  156  THR LEU GLU VAL GLU PRO SER ASP THR ILE GLU ASN VAL          
SEQRES   3 f  156  LYS ALA LYS ILE GLN ASP LYS GLU GLY ILE PRO PRO ASP          
SEQRES   4 f  156  GLN GLN ARG LEU ILE PHE ALA GLY LYS GLN LEU GLU ASP          
SEQRES   5 f  156  GLY ARG THR LEU SER ASP TYR ASN ILE GLN LYS GLU SER          
SEQRES   6 f  156  THR LEU HIS LEU VAL LEU ARG LEU ARG GLY GLY ALA LYS          
SEQRES   7 f  156  LYS ARG LYS LYS LYS SER TYR THR THR PRO LYS LYS ASN          
SEQRES   8 f  156  LYS HIS LYS ARG LYS LYS VAL LYS LEU ALA VAL LEU LYS          
SEQRES   9 f  156  TYR TYR LYS VAL ASP GLU ASN GLY LYS ILE SER ARG LEU          
SEQRES  10 f  156  ARG ARG GLU CYS PRO SER ASP GLU CYS GLY ALA GLY VAL          
SEQRES  11 f  156  PHE MET ALA SER HIS PHE ASP ARG HIS TYR CYS GLY LYS          
SEQRES  12 f  156  CYS CYS LEU THR TYR CYS PHE ASN LYS PRO GLU ASP LYS          
SEQRES   1 g  317  MET THR GLU GLN MET THR LEU ARG GLY THR LEU LYS GLY          
SEQRES   2 g  317  HIS ASN GLY TRP VAL THR GLN ILE ALA THR THR PRO GLN          
SEQRES   3 g  317  PHE PRO ASP MET ILE LEU SER ALA SER ARG ASP LYS THR          
SEQRES   4 g  317  ILE ILE MET TRP LYS LEU THR ARG ASP GLU THR ASN TYR          
SEQRES   5 g  317  GLY ILE PRO GLN ARG ALA LEU ARG GLY HIS SER HIS PHE          
SEQRES   6 g  317  VAL SER ASP VAL VAL ILE SER SER ASP GLY GLN PHE ALA          
SEQRES   7 g  317  LEU SER GLY SER TRP ASP GLY THR LEU ARG LEU TRP ASP          
SEQRES   8 g  317  LEU THR THR GLY THR THR THR ARG ARG PHE VAL GLY HIS          
SEQRES   9 g  317  THR LYS ASP VAL LEU SER VAL ALA PHE SER SER ASP ASN          
SEQRES  10 g  317  ARG GLN ILE VAL SER GLY SER ARG ASP LYS THR ILE LYS          
SEQRES  11 g  317  LEU TRP ASN THR LEU GLY VAL CYS LYS TYR THR VAL GLN          
SEQRES  12 g  317  ASP GLU SER HIS SER GLU TRP VAL SER CYS VAL ARG PHE          
SEQRES  13 g  317  SER PRO ASN SER SER ASN PRO ILE ILE VAL SER CYS GLY          
SEQRES  14 g  317  TRP ASP LYS LEU VAL LYS VAL TRP ASN LEU ALA ASN CYS          
SEQRES  15 g  317  LYS LEU LYS THR ASN HIS ILE GLY HIS THR GLY TYR LEU          
SEQRES  16 g  317  ASN THR VAL THR VAL SER PRO ASP GLY SER LEU CYS ALA          
SEQRES  17 g  317  SER GLY GLY LYS ASP GLY GLN ALA MET LEU TRP ASP LEU          
SEQRES  18 g  317  ASN GLU GLY LYS HIS LEU TYR THR LEU ASP GLY GLY ASP          
SEQRES  19 g  317  ILE ILE ASN ALA LEU CYS PHE SER PRO ASN ARG TYR TRP          
SEQRES  20 g  317  LEU CYS ALA ALA THR GLY PRO SER ILE LYS ILE TRP ASP          
SEQRES  21 g  317  LEU GLU GLY LYS ILE ILE VAL ASP GLU LEU LYS GLN GLU          
SEQRES  22 g  317  VAL ILE SER THR SER SER LYS ALA GLU PRO PRO GLN CYS          
SEQRES  23 g  317  THR SER LEU ALA TRP SER ALA ASP GLY GLN THR LEU PHE          
SEQRES  24 g  317  ALA GLY TYR THR ASP ASN LEU VAL ARG VAL TRP GLN VAL          
SEQRES  25 g  317  THR ILE GLY THR ARG                                          
SEQRES   1 A  295  MET SER GLY ALA LEU ASP VAL LEU GLN MET LYS GLU GLU          
SEQRES   2 A  295  ASP VAL LEU LYS PHE LEU ALA ALA GLY THR HIS LEU GLY          
SEQRES   3 A  295  GLY THR ASN LEU ASP PHE GLN MET GLU GLN TYR ILE TYR          
SEQRES   4 A  295  LYS ARG LYS SER ASP GLY ILE TYR ILE ILE ASN LEU LYS          
SEQRES   5 A  295  ARG THR TRP GLU LYS LEU LEU LEU ALA ALA ARG ALA ILE          
SEQRES   6 A  295  VAL ALA ILE GLU ASN PRO ALA ASP VAL SER VAL ILE SER          
SEQRES   7 A  295  SER ARG ASN THR GLY GLN ARG ALA VAL LEU LYS PHE ALA          
SEQRES   8 A  295  ALA ALA THR GLY ALA THR PRO ILE ALA GLY ARG PHE THR          
SEQRES   9 A  295  PRO GLY THR PHE THR ASN GLN ILE GLN ALA ALA PHE ARG          
SEQRES  10 A  295  GLU PRO ARG LEU LEU VAL VAL THR ASP PRO ARG ALA ASP          
SEQRES  11 A  295  HIS GLN PRO LEU THR GLU ALA SER TYR VAL ASN LEU PRO          
SEQRES  12 A  295  THR ILE ALA LEU CYS ASN THR ASP SER PRO LEU ARG TYR          
SEQRES  13 A  295  VAL ASP ILE ALA ILE PRO CYS ASN ASN LYS GLY ALA HIS          
SEQRES  14 A  295  SER VAL GLY LEU MET TRP TRP MET LEU ALA ARG GLU VAL          
SEQRES  15 A  295  LEU ARG MET ARG GLY THR ILE SER ARG GLU HIS PRO TRP          
SEQRES  16 A  295  GLU VAL MET PRO ASP LEU TYR PHE TYR ARG ASP PRO GLU          
SEQRES  17 A  295  GLU ILE GLU LYS GLU GLU GLN ALA ALA ALA GLU LYS ALA          
SEQRES  18 A  295  VAL THR LYS GLU GLU PHE GLN GLY GLU TRP THR ALA PRO          
SEQRES  19 A  295  ALA PRO GLU PHE THR ALA THR GLN PRO GLU VAL ALA ASP          
SEQRES  20 A  295  TRP SER GLU GLY VAL GLN VAL PRO SER VAL PRO ILE GLN          
SEQRES  21 A  295  GLN PHE PRO THR GLU ASP TRP SER ALA GLN PRO ALA THR          
SEQRES  22 A  295  GLU ASP TRP SER ALA ALA PRO THR ALA GLN ALA THR GLU          
SEQRES  23 A  295  TRP VAL GLY ALA THR THR ASP TRP SER                          
SEQRES   1 B  264  MET ALA VAL GLY LYS ASN LYS ARG LEU THR LYS GLY GLY          
SEQRES   2 B  264  LYS LYS GLY ALA LYS LYS LYS VAL VAL ASP PRO PHE SER          
SEQRES   3 B  264  LYS LYS ASP TRP TYR ASP VAL LYS ALA PRO ALA MET PHE          
SEQRES   4 B  264  ASN ILE ARG ASN ILE GLY LYS THR LEU VAL THR ARG THR          
SEQRES   5 B  264  GLN GLY THR LYS ILE ALA SER ASP GLY LEU LYS GLY ARG          
SEQRES   6 B  264  VAL PHE GLU VAL SER LEU ALA ASP LEU GLN ASN ASP GLU          
SEQRES   7 B  264  VAL ALA PHE ARG LYS PHE LYS LEU ILE THR GLU ASP VAL          
SEQRES   8 B  264  GLN GLY LYS ASN CYS LEU THR ASN PHE HIS GLY MET ASP          
SEQRES   9 B  264  LEU THR ARG ASP LYS MET CYS SER MET VAL LYS LYS TRP          
SEQRES  10 B  264  GLN THR MET ILE GLU ALA HIS VAL ASP VAL LYS THR THR          
SEQRES  11 B  264  ASP GLY TYR LEU LEU ARG LEU PHE CYS VAL GLY PHE THR          
SEQRES  12 B  264  LYS LYS ARG ASN ASN GLN ILE ARG LYS THR SER TYR ALA          
SEQRES  13 B  264  GLN HIS GLN GLN VAL ARG GLN ILE ARG LYS LYS MET MET          
SEQRES  14 B  264  GLU ILE MET THR ARG GLU VAL GLN THR ASN ASP LEU LYS          
SEQRES  15 B  264  GLU VAL VAL ASN LYS LEU ILE PRO ASP SER ILE GLY LYS          
SEQRES  16 B  264  ASP ILE GLU LYS ALA CYS GLN SER ILE TYR PRO LEU HIS          
SEQRES  17 B  264  ASP VAL PHE VAL ARG LYS VAL LYS MET LEU LYS LYS PRO          
SEQRES  18 B  264  LYS PHE GLU LEU GLY LYS LEU MET GLU LEU HIS GLY GLU          
SEQRES  19 B  264  GLY SER SER SER GLY LYS ALA THR GLY ASP GLU THR GLY          
SEQRES  20 B  264  ALA LYS VAL GLU ARG ALA ASP GLY TYR GLU PRO PRO VAL          
SEQRES  21 B  264  GLN GLU SER VAL                                              
SEQRES   1 C  293  MET ALA ASP ASP ALA GLY ALA ALA GLY GLY PRO GLY GLY          
SEQRES   2 C  293  PRO GLY GLY PRO GLY MET GLY ASN ARG GLY GLY PHE ARG          
SEQRES   3 C  293  GLY GLY PHE GLY SER GLY ILE ARG GLY ARG GLY ARG GLY          
SEQRES   4 C  293  ARG GLY ARG GLY ARG GLY ARG GLY ARG GLY ALA ARG GLY          
SEQRES   5 C  293  GLY LYS ALA GLU ASP LYS GLU TRP MET PRO VAL THR LYS          
SEQRES   6 C  293  LEU GLY ARG LEU VAL LYS ASP MET LYS ILE LYS SER LEU          
SEQRES   7 C  293  GLU GLU ILE TYR LEU PHE SER LEU PRO ILE LYS GLU SER          
SEQRES   8 C  293  GLU ILE ILE ASP PHE PHE LEU GLY ALA SER LEU LYS ASP          
SEQRES   9 C  293  GLU VAL LEU LYS ILE MET PRO VAL GLN LYS GLN THR ARG          
SEQRES  10 C  293  ALA GLY GLN ARG THR ARG PHE LYS ALA PHE VAL ALA ILE          
SEQRES  11 C  293  GLY ASP TYR ASN GLY HIS VAL GLY LEU GLY VAL LYS CYS          
SEQRES  12 C  293  SER LYS GLU VAL ALA THR ALA ILE ARG GLY ALA ILE ILE          
SEQRES  13 C  293  LEU ALA LYS LEU SER ILE VAL PRO VAL ARG ARG GLY TYR          
SEQRES  14 C  293  TRP GLY ASN LYS ILE GLY LYS PRO HIS THR VAL PRO CYS          
SEQRES  15 C  293  LYS VAL THR GLY ARG CYS GLY SER VAL LEU VAL ARG LEU          
SEQRES  16 C  293  ILE PRO ALA PRO ARG GLY THR GLY ILE VAL SER ALA PRO          
SEQRES  17 C  293  VAL PRO LYS LYS LEU LEU MET MET ALA GLY ILE ASP ASP          
SEQRES  18 C  293  CYS TYR THR SER ALA ARG GLY CYS THR ALA THR LEU GLY          
SEQRES  19 C  293  ASN PHE ALA LYS ALA THR PHE ASP ALA ILE SER LYS THR          
SEQRES  20 C  293  TYR SER TYR LEU THR PRO ASP LEU TRP LYS GLU THR VAL          
SEQRES  21 C  293  PHE THR LYS SER PRO TYR GLN GLU PHE THR ASP HIS LEU          
SEQRES  22 C  293  VAL LYS THR HIS THR ARG VAL SER VAL GLN ARG THR GLN          
SEQRES  23 C  293  ALA PRO ALA VAL ALA THR THR                                  
SEQRES   1 E  263  MET ALA ARG GLY PRO LYS LYS HIS LEU LYS ARG VAL ALA          
SEQRES   2 E  263  ALA PRO LYS HIS TRP MET LEU ASP LYS LEU THR GLY VAL          
SEQRES   3 E  263  PHE ALA PRO ARG PRO SER THR GLY PRO HIS LYS LEU ARG          
SEQRES   4 E  263  GLU CYS LEU PRO LEU ILE ILE PHE LEU ARG ASN ARG LEU          
SEQRES   5 E  263  LYS TYR ALA LEU THR GLY ASP GLU VAL LYS LYS ILE CYS          
SEQRES   6 E  263  MET GLN ARG PHE ILE LYS ILE ASP GLY LYS VAL ARG THR          
SEQRES   7 E  263  ASP ILE THR TYR PRO ALA GLY PHE MET ASP VAL ILE SER          
SEQRES   8 E  263  ILE ASP LYS THR GLY GLU ASN PHE ARG LEU ILE TYR ASP          
SEQRES   9 E  263  THR LYS GLY ARG PHE ALA VAL HIS ARG ILE THR PRO GLU          
SEQRES  10 E  263  GLU ALA LYS TYR LYS LEU CYS LYS VAL ARG LYS ILE PHE          
SEQRES  11 E  263  VAL GLY THR LYS GLY ILE PRO HIS LEU VAL THR HIS ASP          
SEQRES  12 E  263  ALA ARG THR ILE ARG TYR PRO ASP PRO LEU ILE LYS VAL          
SEQRES  13 E  263  ASN ASP THR ILE GLN ILE ASP LEU GLU THR GLY LYS ILE          
SEQRES  14 E  263  THR ASP PHE ILE LYS PHE ASP THR GLY ASN LEU CYS MET          
SEQRES  15 E  263  VAL THR GLY GLY ALA ASN LEU GLY ARG ILE GLY VAL ILE          
SEQRES  16 E  263  THR ASN ARG GLU ARG HIS PRO GLY SER PHE ASP VAL VAL          
SEQRES  17 E  263  HIS VAL LYS ASP ALA ASN GLY ASN SER PHE ALA THR ARG          
SEQRES  18 E  263  LEU SER ASN ILE PHE VAL ILE GLY LYS GLY ASN LYS PRO          
SEQRES  19 E  263  TRP ILE SER LEU PRO ARG GLY LYS GLY ILE ARG LEU THR          
SEQRES  20 E  263  ILE ALA GLU GLU ARG ASP LYS ARG LEU ALA ALA LYS GLN          
SEQRES  21 E  263  SER SER GLY                                                  
SEQRES   1 G  249  MET LYS LEU ASN ILE SER PHE PRO ALA THR GLY CYS GLN          
SEQRES   2 G  249  LYS LEU ILE GLU VAL ASP ASP GLU ARG LYS LEU ARG THR          
SEQRES   3 G  249  PHE TYR GLU LYS ARG MET ALA THR GLU VAL ALA ALA ASP          
SEQRES   4 G  249  ALA LEU GLY GLU GLU TRP LYS GLY TYR VAL VAL ARG ILE          
SEQRES   5 G  249  SER GLY GLY ASN ASP LYS GLN GLY PHE PRO MET LYS GLN          
SEQRES   6 G  249  GLY VAL LEU THR HIS GLY ARG VAL ARG LEU LEU LEU SER          
SEQRES   7 G  249  LYS GLY HIS SER CYS TYR ARG PRO ARG ARG THR GLY GLU          
SEQRES   8 G  249  ARG LYS ARG LYS SER VAL ARG GLY CYS ILE VAL ASP ALA          
SEQRES   9 G  249  ASN LEU SER VAL LEU ASN LEU VAL ILE VAL LYS LYS GLY          
SEQRES  10 G  249  GLU LYS ASP ILE PRO GLY LEU THR ASP THR THR VAL PRO          
SEQRES  11 G  249  ARG ARG LEU GLY PRO LYS ARG ALA SER ARG ILE ARG LYS          
SEQRES  12 G  249  LEU PHE ASN LEU SER LYS GLU ASP ASP VAL ARG GLN TYR          
SEQRES  13 G  249  VAL VAL ARG LYS PRO LEU ASN LYS GLU GLY LYS LYS PRO          
SEQRES  14 G  249  ARG THR LYS ALA PRO LYS ILE GLN ARG LEU VAL THR PRO          
SEQRES  15 G  249  ARG VAL LEU GLN HIS LYS ARG ARG ARG ILE ALA LEU LYS          
SEQRES  16 G  249  LYS GLN ARG THR LYS LYS ASN LYS GLU GLU ALA ALA GLU          
SEQRES  17 G  249  TYR ALA LYS LEU LEU ALA LYS ARG MET LYS GLU ALA LYS          
SEQRES  18 G  249  GLU LYS ARG GLN GLU GLN ILE ALA LYS ARG ARG ARG LEU          
SEQRES  19 G  249  SER SER LEU ARG ALA SER THR SER LYS SER GLU SER SER          
SEQRES  20 G  249  GLN LYS                                                      
SEQRES   1 H  194  MET PHE SER SER SER ALA LYS ILE VAL LYS PRO ASN GLY          
SEQRES   2 H  194  GLU LYS PRO ASP GLU PHE GLU SER GLY ILE SER GLN ALA          
SEQRES   3 H  194  LEU LEU GLU LEU GLU MET ASN SER ASP LEU LYS ALA GLN          
SEQRES   4 H  194  LEU ARG GLU LEU ASN ILE THR ALA ALA LYS GLU ILE GLU          
SEQRES   5 H  194  VAL GLY GLY GLY ARG LYS ALA ILE ILE ILE PHE VAL PRO          
SEQRES   6 H  194  VAL PRO GLN LEU LYS SER PHE GLN LYS ILE GLN VAL ARG          
SEQRES   7 H  194  LEU VAL ARG GLU LEU GLU LYS LYS PHE SER GLY LYS HIS          
SEQRES   8 H  194  VAL VAL PHE ILE ALA GLN ARG ARG ILE LEU PRO LYS PRO          
SEQRES   9 H  194  THR ARG LYS SER ARG THR LYS ASN LYS GLN LYS ARG PRO          
SEQRES  10 H  194  ARG SER ARG THR LEU THR ALA VAL HIS ASP ALA ILE LEU          
SEQRES  11 H  194  GLU ASP LEU VAL PHE PRO SER GLU ILE VAL GLY LYS ARG          
SEQRES  12 H  194  ILE ARG VAL LYS LEU ASP GLY SER ARG LEU ILE LYS VAL          
SEQRES  13 H  194  HIS LEU ASP LYS ALA GLN GLN ASN ASN VAL GLU HIS LYS          
SEQRES  14 H  194  VAL GLU THR PHE SER GLY VAL TYR LYS LYS LEU THR GLY          
SEQRES  15 H  194  LYS ASP VAL ASN PHE GLU PHE PRO GLU PHE GLN LEU              
SEQRES   1 I  208  MET GLY ILE SER ARG ASP ASN TRP HIS LYS ARG ARG LYS          
SEQRES   2 I  208  THR GLY GLY LYS ARG LYS PRO TYR HIS LYS LYS ARG LYS          
SEQRES   3 I  208  TYR GLU LEU GLY ARG PRO ALA ALA ASN THR LYS ILE GLY          
SEQRES   4 I  208  PRO ARG ARG ILE HIS THR VAL ARG VAL ARG GLY GLY ASN          
SEQRES   5 I  208  LYS LYS TYR ARG ALA LEU ARG LEU ASP VAL GLY ASN PHE          
SEQRES   6 I  208  SER TRP GLY SER GLU CYS CYS THR ARG LYS THR ARG ILE          
SEQRES   7 I  208  ILE ASP VAL VAL TYR ASN ALA SER ASN ASN GLU LEU VAL          
SEQRES   8 I  208  ARG THR LYS THR LEU VAL LYS ASN CYS ILE VAL LEU ILE          
SEQRES   9 I  208  ASP SER THR PRO TYR ARG GLN TRP TYR GLU SER HIS TYR          
SEQRES  10 I  208  ALA LEU PRO LEU GLY ARG LYS LYS GLY ALA LYS LEU THR          
SEQRES  11 I  208  PRO GLU GLU GLU GLU ILE LEU ASN LYS LYS ARG SER LYS          
SEQRES  12 I  208  LYS ILE GLN LYS LYS TYR ASP GLU ARG LYS LYS ASN ALA          
SEQRES  13 I  208  LYS ILE SER SER LEU LEU GLU GLU GLN PHE GLN GLN GLY          
SEQRES  14 I  208  LYS LEU LEU ALA CYS ILE ALA SER ARG PRO GLY GLN CYS          
SEQRES  15 I  208  GLY ARG ALA ASP GLY TYR VAL LEU GLU GLY LYS GLU LEU          
SEQRES  16 I  208  GLU PHE TYR LEU ARG LYS ILE LYS ALA ARG LYS GLY LYS          
SEQRES   1 J  194  MET PRO VAL ALA ARG SER TRP VAL CYS ARG LYS THR TYR          
SEQRES   2 J  194  VAL THR PRO ARG ARG PRO PHE GLU LYS SER ARG LEU ASP          
SEQRES   3 J  194  GLN GLU LEU LYS LEU ILE GLY GLU TYR GLY LEU ARG ASN          
SEQRES   4 J  194  LYS ARG GLU VAL TRP ARG VAL LYS PHE THR LEU ALA LYS          
SEQRES   5 J  194  ILE ARG LYS ALA ALA ARG GLU LEU LEU THR LEU ASP GLU          
SEQRES   6 J  194  LYS ASP PRO ARG ARG LEU PHE GLU GLY ASN ALA LEU LEU          
SEQRES   7 J  194  ARG ARG LEU VAL ARG ILE GLY VAL LEU ASP GLU GLY LYS          
SEQRES   8 J  194  MET LYS LEU ASP TYR ILE LEU GLY LEU LYS ILE GLU ASP          
SEQRES   9 J  194  PHE LEU GLU ARG ARG LEU GLN THR GLN VAL PHE LYS LEU          
SEQRES  10 J  194  GLY LEU ALA LYS SER ILE HIS HIS ALA ARG VAL LEU ILE          
SEQRES  11 J  194  ARG GLN ARG HIS ILE ARG VAL ARG LYS GLN VAL VAL ASN          
SEQRES  12 J  194  ILE PRO SER PHE ILE VAL ARG LEU ASP SER GLN LYS HIS          
SEQRES  13 J  194  ILE ASP PHE SER LEU ARG SER PRO TYR GLY GLY GLY ARG          
SEQRES  14 J  194  PRO GLY ARG VAL LYS ARG LYS ASN ALA LYS LYS GLY GLN          
SEQRES  15 J  194  GLY GLY ALA GLY ALA GLY ASP ASP GLU GLU GLU ASP              
SEQRES   1 L  158  MET ALA ASP ILE GLN THR GLU ARG ALA TYR GLN LYS GLN          
SEQRES   2 L  158  PRO THR ILE PHE GLN ASN LYS LYS ARG VAL LEU LEU GLY          
SEQRES   3 L  158  GLU THR GLY LYS GLU LYS LEU PRO ARG TYR TYR LYS ASN          
SEQRES   4 L  158  ILE GLY LEU GLY PHE LYS THR PRO LYS GLU ALA ILE GLU          
SEQRES   5 L  158  GLY THR TYR ILE ASP LYS LYS CYS PRO PHE THR GLY ASN          
SEQRES   6 L  158  VAL SER ILE ARG GLY ARG ILE LEU SER GLY VAL VAL THR          
SEQRES   7 L  158  LYS MET LYS MET GLN ARG THR ILE VAL ILE ARG ARG ASP          
SEQRES   8 L  158  TYR LEU HIS TYR ILE ARG LYS TYR ASN ARG PHE GLU LYS          
SEQRES   9 L  158  ARG HIS LYS ASN MET SER VAL HIS LEU SER PRO CYS PHE          
SEQRES  10 L  158  ARG ASP VAL GLN ILE GLY ASP ILE VAL THR VAL GLY GLU          
SEQRES  11 L  158  CYS ARG PRO LEU SER LYS THR VAL ARG PHE ASN VAL LEU          
SEQRES  12 L  158  LYS VAL THR LYS ALA ALA GLY THR LYS LYS GLN PHE GLN          
SEQRES  13 L  158  LYS PHE                                                      
SEQRES   1 N  151  MET GLY ARG MET HIS ALA PRO GLY LYS GLY LEU SER GLN          
SEQRES   2 N  151  SER ALA LEU PRO TYR ARG ARG SER VAL PRO THR TRP LEU          
SEQRES   3 N  151  LYS LEU THR SER ASP ASP VAL LYS GLU GLN ILE TYR LYS          
SEQRES   4 N  151  LEU ALA LYS LYS GLY LEU THR PRO SER GLN ILE GLY VAL          
SEQRES   5 N  151  ILE LEU ARG ASP SER HIS GLY VAL ALA GLN VAL ARG PHE          
SEQRES   6 N  151  VAL THR GLY ASN LYS ILE LEU ARG ILE LEU LYS SER LYS          
SEQRES   7 N  151  GLY LEU ALA PRO ASP LEU PRO GLU ASP LEU TYR HIS LEU          
SEQRES   8 N  151  ILE LYS LYS ALA VAL ALA VAL ARG LYS HIS LEU GLU ARG          
SEQRES   9 N  151  ASN ARG LYS ASP LYS ASP ALA LYS PHE ARG LEU ILE LEU          
SEQRES  10 N  151  ILE GLU SER ARG ILE HIS ARG LEU ALA ARG TYR TYR LYS          
SEQRES  11 N  151  THR LYS ARG VAL LEU PRO PRO ASN TRP LYS TYR GLU SER          
SEQRES  12 N  151  SER THR ALA SER ALA LEU VAL ALA                              
SEQRES   1 O  151  MET ALA PRO ARG LYS GLY LYS GLU LYS LYS GLU GLU GLN          
SEQRES   2 O  151  VAL ILE SER LEU GLY PRO GLN VAL ALA GLU GLY GLU ASN          
SEQRES   3 O  151  VAL PHE GLY VAL CYS HIS ILE PHE ALA SER PHE ASN ASP          
SEQRES   4 O  151  THR PHE VAL HIS VAL THR ASP LEU SER GLY LYS GLU THR          
SEQRES   5 O  151  ILE CYS ARG VAL THR GLY GLY MET LYS VAL LYS ALA ASP          
SEQRES   6 O  151  ARG ASP GLU SER SER PRO TYR ALA ALA MET LEU ALA ALA          
SEQRES   7 O  151  GLN ASP VAL ALA GLN ARG CYS LYS GLU LEU GLY ILE THR          
SEQRES   8 O  151  ALA LEU HIS ILE LYS LEU ARG ALA THR GLY GLY ASN ARG          
SEQRES   9 O  151  THR LYS THR PRO GLY PRO GLY ALA GLN SER ALA LEU ARG          
SEQRES  10 O  151  ALA LEU ALA ARG SER GLY MET LYS ILE GLY ARG ILE GLU          
SEQRES  11 O  151  ASP VAL THR PRO ILE PRO SER ASP SER THR ARG ARG LYS          
SEQRES  12 O  151  GLY GLY ARG ARG GLY ARG ARG LEU                              
SEQRES   1 V   83  MET GLN ASN ASP ALA GLY GLU PHE VAL ASP LEU TYR VAL          
SEQRES   2 V   83  PRO ARG LYS CYS SER ALA SER ASN ARG ILE ILE GLY ALA          
SEQRES   3 V   83  LYS ASP HIS ALA SER ILE GLN MET ASN VAL ALA GLU VAL          
SEQRES   4 V   83  ASP LYS VAL THR GLY ARG PHE ASN GLY GLN PHE LYS THR          
SEQRES   5 V   83  TYR ALA ILE CYS GLY ALA ILE ARG ARG MET GLY GLU SER          
SEQRES   6 V   83  ASP ASP SER ILE LEU ARG LEU ALA LYS ALA ASP GLY ILE          
SEQRES   7 V   83  VAL SER LYS ASN PHE                                          
SEQRES   1 W  130  MET VAL ARG MET ASN VAL LEU ALA ASP ALA LEU LYS SER          
SEQRES   2 W  130  ILE ASN ASN ALA GLU LYS ARG GLY LYS ARG GLN VAL LEU          
SEQRES   3 W  130  ILE ARG PRO CYS SER LYS VAL ILE VAL ARG PHE LEU THR          
SEQRES   4 W  130  VAL MET MET LYS HIS GLY TYR ILE GLY GLU PHE GLU ILE          
SEQRES   5 W  130  ILE ASP ASP HIS ARG ALA GLY LYS ILE VAL VAL ASN LEU          
SEQRES   6 W  130  THR GLY ARG LEU ASN LYS CYS GLY VAL ILE SER PRO ARG          
SEQRES   7 W  130  PHE ASP VAL GLN LEU LYS ASP LEU GLU LYS TRP GLN ASN          
SEQRES   8 W  130  ASN LEU LEU PRO SER ARG GLN PHE GLY PHE ILE VAL LEU          
SEQRES   9 W  130  THR THR SER ALA GLY ILE MET ASP HIS GLU GLU ALA ARG          
SEQRES  10 W  130  ARG LYS HIS THR GLY GLY LYS ILE LEU GLY PHE PHE PHE          
SEQRES   1 X  143  MET GLY LYS CYS ARG GLY LEU ARG THR ALA ARG LYS LEU          
SEQRES   2 X  143  ARG SER HIS ARG ARG ASP GLN LYS TRP HIS ASP LYS GLN          
SEQRES   3 X  143  TYR LYS LYS ALA HIS LEU GLY THR ALA LEU LYS ALA ASN          
SEQRES   4 X  143  PRO PHE GLY GLY ALA SER HIS ALA LYS GLY ILE VAL LEU          
SEQRES   5 X  143  GLU LYS VAL GLY VAL GLU ALA LYS GLN PRO ASN SER ALA          
SEQRES   6 X  143  ILE ARG LYS CYS VAL ARG VAL GLN LEU ILE LYS ASN GLY          
SEQRES   7 X  143  LYS LYS ILE THR ALA PHE VAL PRO ASN ASP GLY CYS LEU          
SEQRES   8 X  143  ASN PHE ILE GLU GLU ASN ASP GLU VAL LEU VAL ALA GLY          
SEQRES   9 X  143  PHE GLY ARG LYS GLY HIS ALA VAL GLY ASP ILE PRO GLY          
SEQRES  10 X  143  VAL ARG PHE LYS VAL VAL LYS VAL ALA ASN VAL SER LEU          
SEQRES  11 X  143  LEU ALA LEU TYR LYS GLY LYS LYS GLU ARG PRO ARG SER          
SEQRES   1 Y  133  MET ASN ASP THR VAL THR ILE ARG THR ARG LYS PHE MET          
SEQRES   2 Y  133  THR ASN ARG LEU LEU GLN ARG LYS GLN MET VAL ILE ASP          
SEQRES   3 Y  133  VAL LEU HIS PRO GLY LYS ALA THR VAL PRO LYS THR GLU          
SEQRES   4 Y  133  ILE ARG GLU LYS LEU ALA LYS MET TYR LYS THR THR PRO          
SEQRES   5 Y  133  ASP VAL ILE PHE VAL PHE GLY PHE ARG THR HIS PHE GLY          
SEQRES   6 Y  133  GLY GLY LYS THR THR GLY PHE GLY MET ILE TYR ASP SER          
SEQRES   7 Y  133  LEU ASP TYR ALA LYS LYS ASN GLU PRO LYS HIS ARG LEU          
SEQRES   8 Y  133  ALA ARG HIS GLY LEU TYR GLU LYS LYS LYS THR SER ARG          
SEQRES   9 Y  133  LYS GLN ARG LYS GLU ARG LYS ASN ARG MET LYS LYS VAL          
SEQRES  10 Y  133  ARG GLY THR ALA LYS ALA ASN VAL GLY ALA GLY LYS LYS          
SEQRES  11 Y  133  PRO LYS GLU                                                  
SEQRES   1 b   84  MET PRO LEU ALA LYS ASP LEU LEU HIS PRO SER PRO GLU          
SEQRES   2 b   84  GLU GLU LYS ARG LYS HIS LYS LYS LYS ARG LEU VAL GLN          
SEQRES   3 b   84  SER PRO ASN SER TYR PHE MET ASP VAL LYS CYS PRO GLY          
SEQRES   4 b   84  CYS TYR LYS ILE THR THR VAL PHE SER HIS ALA GLN THR          
SEQRES   5 b   84  VAL VAL LEU CYS VAL GLY CYS SER THR VAL LEU CYS GLN          
SEQRES   6 b   84  PRO THR GLY GLY LYS ALA ARG LEU THR GLU GLY CYS SER          
SEQRES   7 b   84  PHE ARG ARG LYS GLN HIS                                      
SEQRES   1 e   59  LYS VAL HIS GLY SER LEU ALA ARG ALA GLY LYS VAL ARG          
SEQRES   2 e   59  GLY GLN THR PRO LYS VAL ALA LYS GLN GLU LYS LYS LYS          
SEQRES   3 e   59  LYS LYS THR GLY ARG ALA LYS ARG ARG MET GLN TYR ASN          
SEQRES   4 e   59  ARG ARG PHE VAL ASN VAL VAL PRO THR PHE GLY LYS LYS          
SEQRES   5 e   59  LYS GLY PRO ASN ALA ASN SER                                  
SEQRES   1 x  252  MET GLU SER GLU MET GLU THR GLN SER ALA ARG ALA GLU          
SEQRES   2 x  252  GLU GLY PHE THR GLN VAL THR ARG LYS GLY GLY ARG ARG          
SEQRES   3 x  252  ALA LYS LYS ARG GLN ALA GLU GLN LEU SER ALA ALA GLY          
SEQRES   4 x  252  GLU GLY GLY ASP ALA GLY ARG MET ASP THR GLU GLU ALA          
SEQRES   5 x  252  ARG PRO ALA LYS ARG PRO VAL PHE PRO PRO LEU CYS GLY          
SEQRES   6 x  252  ASP GLY LEU LEU SER GLY LYS GLU GLU THR ARG LYS ILE          
SEQRES   7 x  252  PRO VAL PRO ALA ASN ARG TYR THR PRO LEU LYS GLU ASN          
SEQRES   8 x  252  TRP MET LYS ILE PHE THR PRO ILE VAL GLU HIS LEU GLY          
SEQRES   9 x  252  LEU GLN ILE ARG PHE ASN LEU LYS SER ARG ASN VAL GLU          
SEQRES  10 x  252  ILE ARG THR CYS LYS GLU THR LYS ASP VAL SER ALA LEU          
SEQRES  11 x  252  THR LYS ALA ALA ASP PHE VAL LYS ALA PHE ILE LEU GLY          
SEQRES  12 x  252  PHE GLN VAL GLU ASP ALA LEU ALA LEU ILE ARG LEU ASP          
SEQRES  13 x  252  ASP LEU PHE LEU GLU SER PHE GLU ILE THR ASP VAL LYS          
SEQRES  14 x  252  PRO LEU LYS GLY ASP HIS LEU SER ARG ALA ILE GLY ARG          
SEQRES  15 x  252  ILE ALA GLY LYS GLY GLY LYS THR LYS PHE THR ILE GLU          
SEQRES  16 x  252  ASN VAL THR ARG THR ARG ILE VAL LEU ALA ASP VAL LYS          
SEQRES  17 x  252  VAL HIS ILE LEU GLY SER PHE GLN ASN ILE LYS MET ALA          
SEQRES  18 x  252  ARG THR ALA ILE CYS ASN LEU ILE LEU GLY ASN PRO PRO          
SEQRES  19 x  252  SER LYS VAL TYR GLY ASN ILE ARG ALA VAL ALA SER ARG          
SEQRES  20 x  252  SER ALA ASP ARG PHE                                          
SEQRES   1 y  412  MET ALA PRO VAL GLU HIS VAL VAL ALA ASP ALA GLY ALA          
SEQRES   2 y  412  PHE LEU ARG HIS ALA ALA LEU GLN ASP ILE GLY LYS ASN          
SEQRES   3 y  412  ILE TYR THR ILE ARG GLU VAL VAL THR GLU ILE ARG ASP          
SEQRES   4 y  412  LYS ALA THR ARG ARG ARG LEU ALA VAL LEU PRO TYR GLU          
SEQRES   5 y  412  LEU ARG PHE LYS GLU PRO LEU PRO GLU TYR VAL ARG LEU          
SEQRES   6 y  412  VAL THR GLU PHE SER LYS LYS THR GLY ASP TYR PRO SER          
SEQRES   7 y  412  LEU SER ALA THR ASP ILE GLN VAL LEU ALA LEU THR TYR          
SEQRES   8 y  412  GLN LEU GLU ALA GLU PHE VAL GLY VAL SER HIS LEU LYS          
SEQRES   9 y  412  GLN GLU PRO GLN LYS VAL LYS VAL SER SER SER ILE GLN          
SEQRES  10 y  412  HIS PRO GLU THR PRO LEU HIS ILE SER GLY PHE HIS LEU          
SEQRES  11 y  412  PRO TYR LYS PRO LYS PRO PRO GLN GLU THR GLU LYS GLY          
SEQRES  12 y  412  HIS SER ALA CYS GLU PRO GLU ASN LEU GLU PHE SER SER          
SEQRES  13 y  412  PHE MET PHE TRP ARG ASN PRO LEU PRO ASN ILE ASP HIS          
SEQRES  14 y  412  GLU LEU GLN GLU LEU LEU ILE ASP ARG GLY GLU ASP VAL          
SEQRES  15 y  412  PRO SER GLU GLU GLU GLU GLU GLU GLU ASN GLY PHE GLU          
SEQRES  16 y  412  ASP ARG LYS ASP ASP SER ASP ASP ASP GLY GLY GLY TRP          
SEQRES  17 y  412  ILE THR PRO SER ASN ILE LYS GLN ILE GLN GLN GLU LEU          
SEQRES  18 y  412  GLU GLN CYS ASP VAL PRO GLU ASP VAL ARG VAL GLY CYS          
SEQRES  19 y  412  LEU THR THR ASP PHE ALA MET GLN ASN VAL LEU LEU GLN          
SEQRES  20 y  412  MET GLY LEU HIS VAL LEU ALA VAL ASN GLY MET LEU ILE          
SEQRES  21 y  412  ARG GLU ALA ARG SER TYR ILE LEU ARG CYS HIS GLY CYS          
SEQRES  22 y  412  PHE LYS THR THR SER ASP MET SER ARG VAL PHE CYS SER          
SEQRES  23 y  412  HIS CYS GLY ASN LYS THR LEU LYS LYS VAL SER VAL THR          
SEQRES  24 y  412  VAL SER ASP ASP GLY THR LEU HIS MET HIS PHE SER ARG          
SEQRES  25 y  412  ASN PRO LYS VAL LEU ASN PRO ARG GLY LEU ARG TYR SER          
SEQRES  26 y  412  LEU PRO THR PRO LYS GLY GLY LYS TYR ALA ILE ASN PRO          
SEQRES  27 y  412  HIS LEU THR GLU ASP GLN ARG PHE PRO GLN LEU ARG LEU          
SEQRES  28 y  412  SER GLN LYS ALA ARG GLN LYS THR ASN VAL PHE ALA PRO          
SEQRES  29 y  412  ASP TYR ILE ALA GLY VAL SER PRO PHE VAL GLU ASN ASP          
SEQRES  30 y  412  ILE SER SER ARG SER ALA THR LEU GLN VAL ARG ASP SER          
SEQRES  31 y  412  THR LEU GLY ALA GLY ARG ARG ARG LEU ASN PRO ASN ALA          
SEQRES  32 y  412  SER ARG LYS LYS PHE VAL LYS LYS ARG                          
SEQRES   1 u  804  MET ALA ALA HIS ARG PRO GLY PRO LEU LYS GLN GLN ASN          
SEQRES   2 u  804  LYS ALA HIS LYS GLY GLY ARG HIS ARG GLY ARG GLY SER          
SEQRES   3 u  804  ALA GLN ARG ASP GLY LYS GLY ARG LEU ALA LEU LYS THR          
SEQRES   4 u  804  LEU SER LYS LYS VAL ARG LYS GLU LEU SER ARG VAL ASP          
SEQRES   5 u  804  GLN ARG HIS ARG ALA SER GLN LEU ARG LYS GLN LYS LYS          
SEQRES   6 u  804  GLU ALA VAL LEU ALA GLU LYS ARG GLN LEU GLY GLY LYS          
SEQRES   7 u  804  ASP GLY PRO PRO HIS GLN VAL LEU VAL VAL PRO LEU HIS          
SEQRES   8 u  804  SER ARG ILE SER LEU PRO GLU ALA MET GLN LEU LEU GLN          
SEQRES   9 u  804  ASP ARG ASP THR GLY THR VAL HIS LEU ASN GLU LEU GLY          
SEQRES  10 u  804  ASN THR GLN ASN PHE MET LEU LEU CYS PRO ARG LEU LYS          
SEQRES  11 u  804  HIS ARG TRP PHE PHE THR SER ALA ARG PRO GLY ASP LEU          
SEQRES  12 u  804  HIS VAL VAL LEU ASP MET ALA LYS VAL ALA ASP THR ILE          
SEQRES  13 u  804  LEU PHE LEU LEU ASP PRO LEU GLU GLY TRP ASP SER THR          
SEQRES  14 u  804  GLY ASP TYR CYS LEU SER CYS LEU PHE ALA GLN GLY LEU          
SEQRES  15 u  804  PRO THR TYR THR LEU ALA VAL GLN GLY ILE SER GLY LEU          
SEQRES  16 u  804  PRO LEU LYS LYS GLN ILE ASP THR ARG LYS LYS LEU SER          
SEQRES  17 u  804  LYS ALA VAL GLU LYS ARG PHE PRO HIS ASP LYS LEU LEU          
SEQRES  18 u  804  LEU LEU ASP THR GLN GLN GLU ALA GLY MET LEU LEU ARG          
SEQRES  19 u  804  GLN LEU ALA ASN GLN LYS GLN GLN HIS LEU ALA PHE ARG          
SEQRES  20 u  804  ASP ARG ARG ALA TYR LEU PHE ALA HIS ALA VAL ASP PHE          
SEQRES  21 u  804  VAL PRO SER GLU GLU ASN ASN LEU VAL GLY THR LEU LYS          
SEQRES  22 u  804  ILE SER GLY TYR VAL ARG GLY GLN THR LEU ASN VAL ASN          
SEQRES  23 u  804  ARG LEU LEU HIS ILE VAL GLY TYR GLY ASP PHE GLN MET          
SEQRES  24 u  804  LYS GLN ILE ASP ALA PRO GLY ASP PRO PHE PRO LEU ASN          
SEQRES  25 u  804  PRO ARG GLY ILE LYS PRO GLN LYS ASP PRO ASP MET ALA          
SEQRES  26 u  804  MET GLU ILE CYS ALA THR ASP ALA VAL ASP ASP MET GLU          
SEQRES  27 u  804  GLU GLY LEU LYS VAL LEU MET LYS ALA ASP PRO GLY ARG          
SEQRES  28 u  804  GLN GLU SER LEU GLN ALA GLU VAL ILE PRO ASP PRO MET          
SEQRES  29 u  804  GLU GLY GLU GLN THR TRP PRO THR GLU GLU GLU LEU SER          
SEQRES  30 u  804  GLU ALA LYS ASP PHE LEU LYS GLU SER SER LYS VAL VAL          
SEQRES  31 u  804  LYS LYS VAL PRO LYS GLY THR SER SER TYR GLN ALA GLU          
SEQRES  32 u  804  TRP ILE LEU ASP GLY GLY SER GLN SER GLY GLY GLU GLY          
SEQRES  33 u  804  ASP GLU TYR GLU TYR ASP ASP MET GLU HIS GLU ASP PHE          
SEQRES  34 u  804  MET GLU GLU GLU SER GLN ASP GLU SER SER GLU GLU GLU          
SEQRES  35 u  804  GLU GLU TYR GLU THR MET THR ILE GLY GLU SER VAL HIS          
SEQRES  36 u  804  ASP ASP LEU TYR ASP LYS LYS VAL ASP GLU GLU ALA GLU          
SEQRES  37 u  804  ALA LYS MET LEU GLU LYS TYR LYS GLN GLU ARG LEU GLU          
SEQRES  38 u  804  GLU MET PHE PRO ASP GLU VAL ASP THR PRO ARG ASP VAL          
SEQRES  39 u  804  ALA ALA ARG ILE ARG PHE GLN LYS TYR ARG GLY LEU LYS          
SEQRES  40 u  804  SER PHE ARG THR SER PRO TRP ASP PRO LYS GLU ASN LEU          
SEQRES  41 u  804  PRO GLN ASP TYR ALA ARG ILE PHE GLN PHE GLN ASN PHE          
SEQRES  42 u  804  THR ASN THR ARG LYS SER ILE PHE LYS GLU VAL GLU GLU          
SEQRES  43 u  804  LYS GLU VAL GLU GLY ALA GLU VAL GLY TRP TYR VAL THR          
SEQRES  44 u  804  LEU HIS VAL SER GLU VAL PRO VAL SER VAL VAL GLU CYS          
SEQRES  45 u  804  PHE ARG GLN GLY THR PRO LEU ILE ALA PHE SER LEU LEU          
SEQRES  46 u  804  PRO HIS GLU GLN LYS MET SER VAL LEU ASN MET VAL VAL          
SEQRES  47 u  804  ARG ARG ASP PRO GLY ASN THR GLU PRO VAL LYS ALA LYS          
SEQRES  48 u  804  GLU GLU LEU ILE PHE HIS CYS GLY PHE ARG ARG PHE ARG          
SEQRES  49 u  804  ALA SER PRO LEU PHE SER GLN HIS THR ALA ALA ASP LYS          
SEQRES  50 u  804  HIS LYS LEU GLN ARG PHE LEU THR ALA ASP MET ALA LEU          
SEQRES  51 u  804  VAL ALA THR VAL TYR ALA PRO ILE THR PHE PRO PRO ALA          
SEQRES  52 u  804  SER VAL LEU LEU PHE LYS GLN LYS SER ASN GLY MET HIS          
SEQRES  53 u  804  SER LEU ILE ALA THR GLY HIS LEU MET SER VAL ASP PRO          
SEQRES  54 u  804  ASP ARG MET VAL ILE LYS ARG VAL VAL LEU SER GLY HIS          
SEQRES  55 u  804  PRO PHE LYS ILE PHE THR LYS MET ALA VAL VAL ARG TYR          
SEQRES  56 u  804  MET PHE PHE ASN ARG GLU ASP VAL LEU TRP PHE LYS PRO          
SEQRES  57 u  804  VAL GLU LEU ARG THR LYS TRP GLY ARG ARG GLY HIS ILE          
SEQRES  58 u  804  LYS GLU PRO LEU GLY THR HIS GLY HIS MET LYS CYS SER          
SEQRES  59 u  804  PHE ASP GLY LYS LEU LYS SER GLN ASP THR VAL LEU MET          
SEQRES  60 u  804  ASN LEU TYR LYS ARG VAL PHE PRO LYS TRP THR TYR ASP          
SEQRES  61 u  804  PRO TYR VAL PRO GLU PRO VAL PRO TRP LEU LYS SER GLU          
SEQRES  62 u  804  ILE SER SER THR VAL PRO GLN GLY GLY MET GLU                  
SEQRES   1 w  437  MET PRO LYS PHE LYS ALA ALA ARG GLY VAL GLY GLY GLN          
SEQRES   2 w  437  GLU LYS HIS ALA PRO LEU ALA ASP GLN ILE LEU ALA GLY          
SEQRES   3 w  437  ASN ALA VAL ARG ALA GLY VAL ARG GLU LYS ARG ARG GLY          
SEQRES   4 w  437  ARG GLY THR GLY GLU ALA GLU GLU GLU TYR VAL GLY PRO          
SEQRES   5 w  437  ARG LEU SER ARG ARG ILE LEU GLN GLN ALA ARG GLN GLN          
SEQRES   6 w  437  GLN GLU GLU LEU GLU ALA GLU HIS GLY THR GLY ASP LYS          
SEQRES   7 w  437  PRO ALA ALA PRO ARG GLU ARG THR THR ARG LEU GLY PRO          
SEQRES   8 w  437  ARG MET PRO GLN ASP GLY SER ASP ASP GLU ASP GLU GLU          
SEQRES   9 w  437  TRP PRO THR LEU GLU LYS ALA ALA THR MET THR ALA ALA          
SEQRES  10 w  437  GLY HIS HIS ALA GLU VAL VAL VAL ASP PRO GLU ASP GLU          
SEQRES  11 w  437  ARG ALA ILE GLU MET PHE MET ASN LYS ASN PRO PRO ALA          
SEQRES  12 w  437  ARG ARG THR LEU ALA ASP ILE ILE MET GLU LYS LEU THR          
SEQRES  13 w  437  GLU LYS GLN THR GLU VAL GLU THR VAL MET SER GLU VAL          
SEQRES  14 w  437  SER GLY PHE PRO MET PRO GLN LEU ASP PRO ARG VAL LEU          
SEQRES  15 w  437  GLU VAL TYR ARG GLY VAL ARG GLU VAL LEU SER LYS TYR          
SEQRES  16 w  437  ARG SER GLY LYS LEU PRO LYS ALA PHE LYS ILE ILE PRO          
SEQRES  17 w  437  ALA LEU SER ASN TRP GLU GLN ILE LEU TYR VAL THR GLU          
SEQRES  18 w  437  PRO GLU ALA TRP THR ALA ALA ALA MET TYR GLN ALA THR          
SEQRES  19 w  437  ARG ILE PHE ALA SER ASN LEU LYS GLU ARG MET ALA GLN          
SEQRES  20 w  437  ARG PHE TYR ASN LEU VAL LEU LEU PRO ARG VAL ARG ASP          
SEQRES  21 w  437  ASP VAL ALA GLU TYR LYS ARG LEU ASN PHE HIS LEU TYR          
SEQRES  22 w  437  MET ALA LEU LYS LYS ALA LEU PHE LYS PRO GLY ALA TRP          
SEQRES  23 w  437  PHE LYS GLY ILE LEU ILE PRO LEU CYS GLU SER GLY THR          
SEQRES  24 w  437  CYS THR LEU ARG GLU ALA ILE ILE VAL GLY SER ILE ILE          
SEQRES  25 w  437  THR LYS CYS SER ILE PRO VAL LEU HIS SER SER ALA ALA          
SEQRES  26 w  437  MET LEU LYS ILE ALA GLU MET GLU TYR SER GLY ALA ASN          
SEQRES  27 w  437  SER ILE PHE LEU ARG LEU LEU LEU ASP LYS LYS TYR ALA          
SEQRES  28 w  437  LEU PRO TYR ARG VAL LEU ASP ALA LEU VAL PHE HIS PHE          
SEQRES  29 w  437  LEU GLY PHE ARG THR GLU LYS ARG GLU LEU PRO VAL LEU          
SEQRES  30 w  437  TRP HIS GLN CYS LEU LEU THR LEU VAL GLN ARG TYR LYS          
SEQRES  31 w  437  ALA ASP LEU ALA THR ASP GLN LYS GLU ALA LEU LEU GLU          
SEQRES  32 w  437  LEU LEU ARG LEU GLN PRO HIS PRO GLN LEU SER PRO GLU          
SEQRES  33 w  437  ILE ARG ARG GLU LEU GLN SER ALA VAL PRO ARG ASP VAL          
SEQRES  34 w  437  GLU ASP VAL PRO ILE THR VAL GLU                              
SEQRES   1 v  552  MET GLY LYS VAL ASN VAL ALA LYS LEU ARG TYR MET SER          
SEQRES   2 v  552  ARG ASP ASP PHE ARG VAL LEU THR ALA VAL GLU MET GLY          
SEQRES   3 v  552  MET LYS ASN HIS GLU ILE VAL PRO GLY SER LEU ILE ALA          
SEQRES   4 v  552  SER ILE ALA SER LEU LYS HIS GLY GLY CYS ASN LYS VAL          
SEQRES   5 v  552  LEU ARG GLU LEU VAL LYS HIS LYS LEU ILE ALA TRP GLU          
SEQRES   6 v  552  ARG THR LYS THR VAL GLN GLY TYR ARG LEU THR ASN ALA          
SEQRES   7 v  552  GLY TYR ASP TYR LEU ALA LEU LYS THR LEU SER SER ARG          
SEQRES   8 v  552  GLN VAL VAL GLU SER VAL GLY ASN GLN MET GLY VAL GLY          
SEQRES   9 v  552  LYS GLU SER ASP ILE TYR ILE VAL ALA ASN GLU GLU GLY          
SEQRES  10 v  552  GLN GLN PHE ALA LEU LYS LEU HIS ARG LEU GLY ARG THR          
SEQRES  11 v  552  SER PHE ARG ASN LEU LYS ASN LYS ARG ASP TYR HIS LYS          
SEQRES  12 v  552  HIS ARG HIS ASN VAL SER TRP LEU TYR LEU SER ARG LEU          
SEQRES  13 v  552  SER ALA MET LYS GLU PHE ALA TYR MET LYS ALA LEU TYR          
SEQRES  14 v  552  GLU ARG LYS PHE PRO VAL PRO LYS PRO ILE ASP TYR ASN          
SEQRES  15 v  552  ARG HIS ALA VAL VAL MET GLU LEU ILE ASN GLY TYR PRO          
SEQRES  16 v  552  LEU CYS GLN ILE HIS HIS VAL GLU ASP PRO ALA SER VAL          
SEQRES  17 v  552  TYR ASP GLU ALA MET GLU LEU ILE VAL LYS LEU ALA ASN          
SEQRES  18 v  552  HIS GLY LEU ILE HIS GLY ASP PHE ASN GLU PHE ASN LEU          
SEQRES  19 v  552  ILE LEU ASP GLU SER ASP HIS ILE THR MET ILE ASP PHE          
SEQRES  20 v  552  PRO GLN MET VAL SER THR SER HIS PRO ASN ALA GLU TRP          
SEQRES  21 v  552  TYR PHE ASP ARG ASP VAL LYS CYS ILE LYS ASP PHE PHE          
SEQRES  22 v  552  MET LYS ARG PHE SER TYR GLU SER GLU LEU PHE PRO THR          
SEQRES  23 v  552  PHE LYS ASP ILE ARG ARG GLU ASP THR LEU ASP VAL GLU          
SEQRES  24 v  552  VAL SER ALA SER GLY TYR THR LYS GLU MET GLN ALA ASP          
SEQRES  25 v  552  ASP GLU LEU LEU HIS PRO LEU GLY PRO ASP ASP LYS ASN          
SEQRES  26 v  552  ILE GLU THR LYS GLU GLY SER GLU PHE SER PHE SER ASP          
SEQRES  27 v  552  GLY GLU VAL ALA GLU LYS ALA GLU VAL TYR GLY SER GLU          
SEQRES  28 v  552  ASN GLU SER GLU ARG ASN CYS LEU GLU GLU SER GLU GLY          
SEQRES  29 v  552  CYS TYR CYS ARG SER SER GLY ASP PRO GLU GLN ILE LYS          
SEQRES  30 v  552  GLU ASP SER LEU SER GLU GLU SER ALA ASP ALA ARG SER          
SEQRES  31 v  552  PHE GLU MET THR GLU PHE ASN GLN ALA LEU GLU GLU ILE          
SEQRES  32 v  552  LYS GLY GLN VAL VAL GLU ASN ASN SER VAL THR GLU PHE          
SEQRES  33 v  552  SER GLU GLU LYS ASN ARG THR GLU ASN TYR ASN ARG GLN          
SEQRES  34 v  552  ASP GLY GLN ARG VAL GLN GLY GLY VAL PRO ALA GLY SER          
SEQRES  35 v  552  ASP GLU TYR GLU ASP GLU CYS PRO HIS LEU ILE ALA LEU          
SEQRES  36 v  552  SER SER LEU ASN ARG GLU PHE ARG PRO PHE ARG ASP GLU          
SEQRES  37 v  552  GLU ASN VAL GLY ALA MET ASN GLN TYR ARG THR ARG THR          
SEQRES  38 v  552  LEU SER ILE THR SER SER GLY SER ALA VAL SER CYS SER          
SEQRES  39 v  552  THR ILE PRO PRO GLU LEU VAL LYS GLN LYS VAL LYS ARG          
SEQRES  40 v  552  GLN LEU THR LYS GLN GLN LYS SER ALA VAL ARG ARG ARG          
SEQRES  41 v  552  LEU GLN LYS GLY GLU ALA ASN ILE PHE THR LYS GLN ARG          
SEQRES  42 v  552  ARG GLU ASN MET GLN ASN ILE LYS SER SER LEU GLU ALA          
SEQRES  43 v  552  ALA SER PHE TRP GLY GLU                                      
SEQRES   1 t  475  MET PRO HIS ARG LYS LYS LYS PRO PHE ILE GLU LYS LYS          
SEQRES   2 t  475  LYS ALA VAL SER PHE HIS LEU VAL HIS ARG SER GLN ARG          
SEQRES   3 t  475  ASP PRO LEU ALA ALA ASP GLU SER ALA PRO GLN ARG VAL          
SEQRES   4 t  475  LEU LEU PRO THR GLN LYS ILE ASP ASN GLU GLU ARG ARG          
SEQRES   5 t  475  ALA GLU GLN ARG LYS TYR GLY VAL PHE PHE ASP ASP ASP          
SEQRES   6 t  475  TYR ASP TYR LEU GLN HIS LEU LYS GLU PRO SER GLY PRO          
SEQRES   7 t  475  SER GLU LEU ILE PRO SER SER THR PHE SER ALA HIS ASN          
SEQRES   8 t  475  ARG ARG GLU GLU LYS GLU GLU THR LEU VAL ILE PRO SER          
SEQRES   9 t  475  THR GLY ILE LYS LEU PRO SER SER VAL PHE ALA SER GLU          
SEQRES  10 t  475  PHE GLU GLU ASP VAL GLY LEU LEU ASN LYS ALA ALA PRO          
SEQRES  11 t  475  VAL SER GLY PRO ARG LEU ASP PHE ASP PRO ASP ILE VAL          
SEQRES  12 t  475  ALA ALA LEU ASP ASP ASP PHE ASP PHE ASP ASP PRO ASP          
SEQRES  13 t  475  ASN LEU LEU GLU ASP ASP PHE ILE LEU GLN ALA ASN LYS          
SEQRES  14 t  475  ALA THR GLY GLU GLU GLU GLY MET ASP ILE GLN LYS SER          
SEQRES  15 t  475  GLU ASN GLU ASP ASP SER GLU TRP GLU ASP VAL ASP ASP          
SEQRES  16 t  475  GLU LYS GLY ASP SER ASN ASP ASP TYR ASP SER ALA GLY          
SEQRES  17 t  475  LEU LEU SER ASP GLU ASP CYS MET SER VAL PRO GLY LYS          
SEQRES  18 t  475  THR HIS ARG ALA ILE ALA ASP HIS LEU PHE TRP SER GLU          
SEQRES  19 t  475  GLU THR LYS SER ARG PHE THR GLU TYR SER MET THR SER          
SEQRES  20 t  475  SER VAL MET ARG ARG ASN GLU GLN LEU THR LEU HIS ASP          
SEQRES  21 t  475  GLU ARG PHE GLU LYS PHE TYR GLU GLN TYR ASP ASP ASP          
SEQRES  22 t  475  GLU ILE GLY ALA LEU ASP ASN ALA GLU LEU GLU GLY SER          
SEQRES  23 t  475  ILE GLN VAL ASP SER ASN ARG LEU GLN GLU VAL LEU ASN          
SEQRES  24 t  475  ASP TYR TYR LYS GLU LYS ALA GLU ASN CYS VAL LYS LEU          
SEQRES  25 t  475  ASN THR LEU GLU PRO LEU GLU ASP GLN ASP LEU PRO MET          
SEQRES  26 t  475  ASN GLU LEU ASP GLU SER GLU GLU GLU GLU MET ILE THR          
SEQRES  27 t  475  VAL VAL LEU GLU GLU ALA LYS GLU LYS TRP ASP CYS GLU          
SEQRES  28 t  475  SER ILE CYS SER THR TYR SER ASN LEU TYR ASN HIS PRO          
SEQRES  29 t  475  GLN LEU ILE LYS TYR GLN PRO LYS PRO LYS GLN ILE ARG          
SEQRES  30 t  475  ILE SER SER LYS THR GLY ILE PRO LEU ASN VAL LEU PRO          
SEQRES  31 t  475  LYS LYS GLY LEU THR ALA LYS GLN THR GLU ARG ILE GLN          
SEQRES  32 t  475  MET ILE ASN GLY SER ASP LEU PRO LYS VAL SER THR GLN          
SEQRES  33 t  475  PRO ARG SER LYS ASN GLU SER LYS GLU ASP LYS ARG ALA          
SEQRES  34 t  475  ARG LYS GLN ALA ILE LYS GLU GLU ARG LYS GLU ARG ARG          
SEQRES  35 t  475  VAL GLU LYS LYS ALA ASN LYS LEU ALA PHE LYS LEU GLU          
SEQRES  36 t  475  LYS ARG ARG GLN GLU LYS GLU LEU LEU ASN LEU LYS LYS          
SEQRES  37 t  475  ASN VAL GLU GLY LEU LYS LEU                                  
HET     ZN  f 200       1                                                       
HET     ZN  y 500       1                                                       
HETNAM      ZN ZINC ION                                                         
FORMUL  36   ZN    2(ZN 2+)                                                     
HELIX    1 AA1 LYS F   18  LYS F   22  5                                   5    
HELIX    2 AA2 PHE F   61  GLN F   65  5                                   5    
HELIX    3 AA3 PRO F   67  SER F   75  1                                   9    
HELIX    4 AA4 HIS F   79  ASN F   83  5                                   5    
HELIX    5 AA5 LYS F   85  GLY F  105  1                                  21    
HELIX    6 AA6 ASN F  107  GLY F  120  1                                  14    
HELIX    7 AA7 SER F  142  ALA F  162  1                                  21    
HELIX    8 AA8 THR F  168  GLY F  183  1                                  16    
HELIX    9 AA9 SER F  187  ARG F  204  1                                  18    
HELIX   10 AB1 ASP M   13  HIS M   28  1                                  16    
HELIX   11 AB2 ILE M   35  ALA M   41  1                                   7    
HELIX   12 AB3 GLU M   58  HIS M   72  1                                  15    
HELIX   13 AB4 ASP M   81  GLY M   90  1                                  10    
HELIX   14 AB5 GLN M  119  LYS M  132  1                                  14    
HELIX   15 AB6 ASP P   21  MET P   28  1                                   8    
HELIX   16 AB7 SER P   29  MET P   34  1                                   6    
HELIX   17 AB8 SER P   38  GLY P   48  1                                  11    
HELIX   18 AB9 ARG P   50  GLU P   66  1                                  17    
HELIX   19 AC1 LEU P   86  VAL P   90  5                                   5    
HELIX   20 AC2 LYS P  108  ILE P  112  5                                   5    
HELIX   21 AC3 TYR P  115  SER P  120  5                                   6    
HELIX   22 AC4 GLU Q   40  ILE Q   42  5                                   3    
HELIX   23 AC5 LEU Q   47  LEU Q   52  1                                   6    
HELIX   24 AC6 LEU Q   52  GLY Q   59  1                                   8    
HELIX   25 AC7 HIS Q   77  VAL Q  100  1                                  24    
HELIX   26 AC8 ASP Q  101  ASP Q  116  1                                  16    
HELIX   27 AC9 ARG Q  117  LEU Q  120  5                                   4    
HELIX   28 AD1 THR R    6  TYR R   20  1                                  15    
HELIX   29 AD2 ASP R   27  ALA R   39  1                                  13    
HELIX   30 AD3 SER R   43  GLN R   62  1                                  20    
HELIX   31 AD4 LEU R   73  ASN R   83  1                                  11    
HELIX   32 AD5 ASP R   99  LEU R  108  1                                  10    
HELIX   33 AD6 LYS S   25  ILE S   30  1                                   6    
HELIX   34 AD7 THR S   31  ILE S   33  5                                   3    
HELIX   35 AD8 GLY S   37  ALA S   48  1                                  12    
HELIX   36 AD9 THR S   60  ASN S   73  1                                  14    
HELIX   37 AE1 PRO S   74  LYS S   78  5                                   5    
HELIX   38 AE2 LEU S   99  ARG S  118  1                                  20    
HELIX   39 AE3 ALA S  119  GLY S  128  1                                  10    
HELIX   40 AE4 THR T    5  VAL T    9  5                                   5    
HELIX   41 AE5 ASN T   10  GLY T   26  1                                  17    
HELIX   42 AE6 ASN T   51  ARG T   67  1                                  17    
HELIX   43 AE7 GLY T   71  TYR T   79  1                                   9    
HELIX   44 AE8 SER T   96  LEU T  110  1                                  15    
HELIX   45 AE9 THR T  124  LYS T  144  1                                  21    
HELIX   46 AF1 ASP Z   51  LYS Z   60  1                                  10    
HELIX   47 AF2 GLU Z   61  TYR Z   65  5                                   5    
HELIX   48 AF3 THR Z   69  LEU Z   77  1                                   9    
HELIX   49 AF4 ARG Z   80  LYS Z   94  1                                  15    
HELIX   50 AF5 LYS A   11  GLY A   22  1                                  12    
HELIX   51 AF6 MET A   34  GLN A   36  5                                   3    
HELIX   52 AF7 ASN A   50  ALA A   67  1                                  18    
HELIX   53 AF8 ASN A   70  ALA A   72  5                                   3    
HELIX   54 AF9 ARG A   80  THR A   82  5                                   3    
HELIX   55 AG1 GLY A   83  GLY A   95  1                                  13    
HELIX   56 AG2 HIS A  131  ASN A  141  1                                  11    
HELIX   57 AG3 GLY A  167  GLY A  187  1                                  21    
HELIX   58 AG4 MET A  198  PHE A  203  5                                   6    
HELIX   59 AG5 ASP A  206  ALA A  216  1                                  11    
HELIX   60 AG6 ASP B   23  SER B   26  5                                   4    
HELIX   61 AG7 ILE B   57  LYS B   63  1                                   7    
HELIX   62 AG8 ALA B   72  LEU B   74  5                                   3    
HELIX   63 AG9 THR B  106  VAL B  114  1                                   9    
HELIX   64 AH1 GLN B  157  GLN B  177  1                                  21    
HELIX   65 AH2 ASP B  180  ILE B  189  1                                  10    
HELIX   66 AH3 ASP B  191  CYS B  201  1                                  11    
HELIX   67 AH4 LEU B  225  GLY B  233  1                                   9    
HELIX   68 AH5 THR C   64  ASP C   72  1                                   9    
HELIX   69 AH6 LEU C   78  PHE C   84  1                                   7    
HELIX   70 AH7 GLU C   90  LEU C   98  1                                   9    
HELIX   71 AH8 GLU C  146  SER C  161  1                                  16    
HELIX   72 AH9 ALA C  207  MET C  216  1                                  10    
HELIX   73 AI1 THR C  232  TYR C  250  1                                  19    
HELIX   74 AI2 THR C  252  TRP C  256  5                                   5    
HELIX   75 AI3 SER C  264  PHE C  269  1                                   6    
HELIX   76 AI4 PRO E   15  MET E   19  5                                   5    
HELIX   77 AI5 LYS E   37  CYS E   41  5                                   5    
HELIX   78 AI6 LEU E   44  ASN E   50  1                                   7    
HELIX   79 AI7 THR E   57  MET E   66  1                                  10    
HELIX   80 AI8 GLU E  117  ALA E  119  5                                   3    
HELIX   81 AI9 THR E  247  SER E  262  1                                  16    
HELIX   82 AJ1 ASP G   20  TYR G   28  1                                   9    
HELIX   83 AJ2 ARG G  137  PHE G  145  1                                   9    
HELIX   84 AJ3 THR G  181  LYS G  230  1                                  50    
HELIX   85 AJ4 ASP H   17  SER H   34  1                                  18    
HELIX   86 AJ5 LYS H   37  LEU H   43  1                                   7    
HELIX   87 AJ6 PRO H   65  PRO H   67  5                                   3    
HELIX   88 AJ7 GLN H   68  ILE H   75  1                                   8    
HELIX   89 AJ8 ILE H   75  PHE H   87  1                                  13    
HELIX   90 AJ9 PRO H  117  THR H  121  5                                   5    
HELIX   91 AK1 LEU H  122  VAL H  134  1                                  13    
HELIX   92 AK2 LYS H  169  THR H  181  1                                  13    
HELIX   93 AK3 ARG I   49  GLY I   51  5                                   3    
HELIX   94 AK4 ASN I   88  THR I   93  1                                   6    
HELIX   95 AK5 SER I  106  ALA I  118  1                                  13    
HELIX   96 AK6 THR I  130  ASN I  138  1                                   9    
HELIX   97 AK7 SER I  142  LYS I  154  1                                  13    
HELIX   98 AK8 SER I  159  GLY I  169  1                                  11    
HELIX   99 AK9 ARG I  178  GLY I  183  1                                   6    
HELIX  100 AL1 GLU I  191  LYS I  206  1                                  16    
HELIX  101 AL2 GLU J   21  GLY J   36  1                                  16    
HELIX  102 AL3 ASN J   39  THR J   62  1                                  24    
HELIX  103 AL4 ASP J   67  ILE J   84  1                                  18    
HELIX  104 AL5 LYS J   93  LEU J  100  5                                   8    
HELIX  105 AL6 LYS J  101  GLU J  107  1                                   7    
HELIX  106 AL7 ARG J  109  LEU J  117  1                                   9    
HELIX  107 AL8 SER J  122  GLN J  132  1                                  11    
HELIX  108 AL9 GLY J  171  LYS J  179  1                                   9    
HELIX  109 AM1 VAL L   23  LYS L   30  1                                   8    
HELIX  110 AM2 PRO L   47  GLY L   53  1                                   7    
HELIX  111 AM3 THR N   29  LEU N   45  1                                  17    
HELIX  112 AM4 THR N   46  SER N   57  1                                  12    
HELIX  113 AM5 GLN N   62  THR N   67  1                                   6    
HELIX  114 AM6 LYS N   70  GLY N   79  1                                  10    
HELIX  115 AM7 PRO N   85  ASN N  105  1                                  21    
HELIX  116 AM8 ASP N  108  LYS N  132  1                                  25    
HELIX  117 AM9 SER O   70  LEU O   88  1                                  19    
HELIX  118 AN1 GLY O  109  SER O  122  1                                  14    
HELIX  119 AN2 CYS V   56  MET V   62  1                                   7    
HELIX  120 AN3 GLU V   64  ASP V   76  1                                  13    
HELIX  121 AN4 ASN W    5  ARG W   20  1                                  16    
HELIX  122 AN5 SER W   31  HIS W   44  1                                  14    
HELIX  123 AN6 ASP W   85  LEU W   93  1                                   9    
HELIX  124 AN7 HIS W  113  HIS W  120  1                                   8    
HELIX  125 AN8 THR X    9  TRP X   22  1                                  14    
HELIX  126 AN9 ASP X   24  LEU X   32  1                                   9    
HELIX  127 AO1 THR X   34  ASN X   39  1                                   6    
HELIX  128 AO2 LEU X  130  GLY X  136  1                                   7    
HELIX  129 AO3 PRO Y   36  TYR Y   48  1                                  13    
HELIX  130 AO4 SER Y   78  GLU Y   86  1                                   9    
HELIX  131 AO5 PRO Y   87  ARG Y   93  1                                   7    
HELIX  132 AO6 SER Y  103  VAL Y  117  1                                  15    
HELIX  133 AO7 ARG Y  118  ALA Y  123  5                                   6    
HELIX  134 AO8 SER b   11  LYS b   18  1                                   8    
HELIX  135 AO9 GLY e   10  THR e   16  1                                   7    
HELIX  136 AP1 GLY e   30  ARG e   40  1                                  11    
HELIX  137 AP2 ARG x   84  ASN x   91  1                                   8    
HELIX  138 AP3 ASN x   91  HIS x  102  1                                  12    
HELIX  139 AP4 SER x  128  GLY x  143  1                                  16    
HELIX  140 AP5 GLN x  145  LEU x  150  1                                   6    
HELIX  141 AP6 LEU x  150  LEU x  155  1                                   6    
HELIX  142 AP7 THR x  166  VAL x  168  5                                   3    
HELIX  143 AP8 GLY x  173  GLY x  185  1                                  13    
HELIX  144 AP9 GLY x  188  THR x  198  1                                  11    
HELIX  145 AQ1 SER x  214  LEU x  230  1                                  17    
HELIX  146 AQ2 PRO x  233  SER x  248  1                                  16    
HELIX  147 AQ3 ASP y   10  ARG y   16  1                                   7    
HELIX  148 AQ4 ILE y   30  GLU y   36  1                                   7    
HELIX  149 AQ5 ASP y   39  ALA y   47  1                                   9    
HELIX  150 AQ6 LEU y   59  LYS y   71  1                                  13    
HELIX  151 AQ7 SER y   80  VAL y   98  1                                  19    
HELIX  152 AQ8 GLY y   99  LEU y  103  5                                   5    
HELIX  153 AQ9 ASP y  238  GLY y  249  1                                  12    
HELIX  154 AR1 SER y  380  LEU y  385  1                                   6    
HELIX  155 AR2 ALA y  394  LEU y  399  1                                   6    
HELIX  156 AR3 SER u   49  ARG u   73  1                                  25    
HELIX  157 AR4 SER u   95  GLN u  104  1                                  10    
HELIX  158 AR5 ASP u  142  LYS u  151  1                                  10    
HELIX  159 AR6 ASP u  167  GLY u  181  1                                  15    
HELIX  160 AR7 PRO u  196  GLU u  212  1                                  17    
HELIX  161 AR8 THR u  225  ASN u  238  1                                  14    
HELIX  162 AR9 LEU u  244  ARG u  250  1                                   7    
HELIX  163 AS1 SER u  398  GLU u  403  1                                   6    
HELIX  164 AS2 GLU u  465  LEU u  480  1                                  16    
HELIX  165 AS3 ALA u  495  PHE u  500  1                                   6    
HELIX  166 AS4 ASP u  523  ARG u  526  5                                   4    
HELIX  167 AS5 ASN u  532  GLU u  546  1                                  15    
HELIX  168 AS6 VAL u  567  GLY u  576  1                                  10    
HELIX  169 AS7 ARG u  720  PHE u  726  1                                   7    
HELIX  170 AS8 ARG w  180  SER w  193  1                                  14    
HELIX  171 AS9 ILE w  206  LEU w  210  5                                   5    
HELIX  172 AT1 ASN w  212  GLU w  221  1                                  10    
HELIX  173 AT2 PRO w  222  TRP w  225  5                                   4    
HELIX  174 AT3 THR w  226  ASN w  240  1                                  15    
HELIX  175 AT4 LYS w  242  VAL w  253  1                                  12    
HELIX  176 AT5 VAL w  253  TYR w  265  1                                  13    
HELIX  177 AT6 ASN w  269  ALA w  279  1                                  11    
HELIX  178 AT7 LYS w  282  ILE w  290  1                                   9    
HELIX  179 AT8 ILE w  290  GLY w  298  1                                   9    
HELIX  180 AT9 THR w  301  CYS w  315  1                                  15    
HELIX  181 AU1 PRO w  318  MET w  332  1                                  15    
HELIX  182 AU2 ALA w  337  ASP w  347  1                                  11    
HELIX  183 AU3 PRO w  353  LEU w  365  1                                  13    
HELIX  184 AU4 GLY w  366  ARG w  368  5                                   3    
HELIX  185 AU5 PRO w  375  TYR w  389  1                                  15    
HELIX  186 AU6 ALA w  394  GLN w  408  1                                  15    
HELIX  187 AU7 LEU w  413  SER w  423  1                                  11    
HELIX  188 AU8 ARG v   14  LYS v   28  1                                  15    
HELIX  189 AU9 PRO v   34  ALA v   42  1                                   9    
HELIX  190 AV1 CYS v   49  VAL v   57  1                                   9    
HELIX  191 AV2 THR v   76  ARG v   91  1                                  16    
HELIX  192 AV3 HIS v  146  GLU v  170  1                                  25    
HELIX  193 AV4 CYS v  197  ILE v  199  5                                   3    
HELIX  194 AV5 ASP v  204  HIS v  222  1                                  19    
HELIX  195 AV6 ASN v  257  PHE v  277  1                                  21    
HELIX  196 AV7 PRO v  497  GLN v  522  1                                  26    
HELIX  197 AV8 ASN v  527  LEU v  544  1                                  18    
HELIX  198 AV9 ASN t  292  ASN t  308  1                                  17    
HELIX  199 AW1 GLU t  425  ASN t  469  1                                  45    
SHEET    1 AA1 5 GLU F 123  THR F 126  0                                        
SHEET    2 AA1 5 GLN F 137  VAL F 141 -1  O  VAL F 139   N  ASP F 124           
SHEET    3 AA1 5 ILE c  42  LYS c  47  1  O  LYS c  47   N  ASP F 140           
SHEET    4 AA1 5 CYS c  27  VAL c  32 -1  N  VAL c  30   O  ARG c  44           
SHEET    5 AA1 5 LYS c  16  THR c  21 -1  N  LYS c  16   O  ARG c  31           
SHEET    1 AA2 4 LEU M  31  GLY M  34  0                                        
SHEET    2 AA2 4 CYS M 108  VAL M 111 -1  O  VAL M 110   N  ALA M  32           
SHEET    3 AA2 4 LEU M  49  ALA M  53 -1  N  VAL M  51   O  VAL M 109           
SHEET    4 AA2 4 LEU M  76  VAL M  79  1  O  ILE M  77   N  LEU M  52           
SHEET    1 AA3 3 VAL P  76  THR P  78  0                                        
SHEET    2 AA3 3 MET P  93  TYR P  97  1  O  GLY P  95   N  VAL P  76           
SHEET    3 AA3 3 PHE P 102  GLU P 106 -1  O  VAL P 105   N  VAL P  94           
SHEET    1 AA4 5 SER Q   9  LYS Q  16  0                                        
SHEET    2 AA4 5 ALA Q  19  ARG Q  27 -1  O  CYS Q  25   N  VAL Q  10           
SHEET    3 AA4 5 VAL Q  66  LYS Q  73 -1  O  ASP Q  67   N  LYS Q  26           
SHEET    4 AA4 5 LEU Q  31  VAL Q  34  1  N  LEU Q  31   O  ILE Q  68           
SHEET    5 AA4 5 ARG Q  37  PRO Q  38 -1  O  ARG Q  37   N  VAL Q  34           
SHEET    1 AA5 2 ILE R  96  VAL R  98  0                                        
SHEET    2 AA5 2 LEU R 117  VAL R 119  1  O  GLN R 118   N  ILE R  96           
SHEET    1 AA6 2 ILE S  12  VAL S  15  0                                        
SHEET    2 AA6 2 THR S  18  ASP S  21 -1  O  ILE S  20   N  LEU S  13           
SHEET    1 AA7 2 GLY T  81  GLN T  83  0                                        
SHEET    2 AA7 2 HIS T  91  SER T  93 -1  O  HIS T  91   N  GLN T  83           
SHEET    1 AA8 2 VAL T 113  LYS T 115  0                                        
SHEET    2 AA8 2 ARG T 121  LEU T 123 -1  O  LYS T 122   N  GLU T 114           
SHEET    1 AA9 3 LEU Z  67  ILE Z  68  0                                        
SHEET    2 AA9 3 ILE Z 108  ARG Z 111 -1  O  TYR Z 109   N  ILE Z  68           
SHEET    3 AA9 3 ILE Z  97  SER Z 101 -1  N  VAL Z 100   O  ILE Z 108           
SHEET    1 AB1 2 LYS c  10  LEU c  11  0                                        
SHEET    2 AB1 2 THR c  57  LEU c  58 -1  O  LEU c  58   N  LYS c  10           
SHEET    1 AB2 2 TYR f 106  VAL f 108  0                                        
SHEET    2 AB2 2 ILE f 114  ARG f 116 -1  O  SER f 115   N  LYS f 107           
SHEET    1 AB3 2 MET f 132  SER f 134  0                                        
SHEET    2 AB3 2 HIS f 139  CYS f 141 -1  O  TYR f 140   N  ALA f 133           
SHEET    1 AB4 4 GLN g   4  LEU g  11  0                                        
SHEET    2 AB4 4 VAL g 307  THR g 313 -1  O  GLN g 311   N  THR g   6           
SHEET    3 AB4 4 LEU g 298  TYR g 302 -1  N  ALA g 300   O  ARG g 308           
SHEET    4 AB4 4 CYS g 286  TRP g 291 -1  N  ALA g 290   O  PHE g 299           
SHEET    1 AB5 4 VAL g  18  THR g  23  0                                        
SHEET    2 AB5 4 MET g  30  SER g  35 -1  O  ALA g  34   N  GLN g  20           
SHEET    3 AB5 4 THR g  39  LEU g  45 -1  O  TRP g  43   N  ILE g  31           
SHEET    4 AB5 4 GLY g  53  ARG g  60 -1  O  ILE g  54   N  LYS g  44           
SHEET    1 AB6 4 VAL g  66  ILE g  71  0                                        
SHEET    2 AB6 4 PHE g  77  SER g  82 -1  O  LEU g  79   N  VAL g  70           
SHEET    3 AB6 4 THR g  86  ASP g  91 -1  O  TRP g  90   N  ALA g  78           
SHEET    4 AB6 4 THR g  96  VAL g 102 -1  O  PHE g 101   N  LEU g  87           
SHEET    1 AB7 4 VAL g 108  PHE g 113  0                                        
SHEET    2 AB7 4 ILE g 120  SER g 124 -1  O  GLY g 123   N  SER g 110           
SHEET    3 AB7 4 ILE g 129  TRP g 132 -1  O  TRP g 132   N  ILE g 120           
SHEET    4 AB7 4 CYS g 138  VAL g 142 -1  O  VAL g 142   N  ILE g 129           
SHEET    1 AB8 4 VAL g 151  ARG g 155  0                                        
SHEET    2 AB8 4 ILE g 164  GLY g 169 -1  O  VAL g 166   N  ARG g 155           
SHEET    3 AB8 4 LEU g 173  ASN g 178 -1  O  LYS g 175   N  SER g 167           
SHEET    4 AB8 4 LYS g 183  ILE g 189 -1  O  LYS g 185   N  VAL g 176           
SHEET    1 AB9 4 LEU g 195  VAL g 200  0                                        
SHEET    2 AB9 4 LEU g 206  GLY g 211 -1  O  GLY g 210   N  ASN g 196           
SHEET    3 AB9 4 GLN g 215  ASP g 220 -1  O  TRP g 219   N  CYS g 207           
SHEET    4 AB9 4 HIS g 226  ASP g 231 -1  O  LEU g 230   N  ALA g 216           
SHEET    1 AC1 4 ALA g 238  PHE g 241  0                                        
SHEET    2 AC1 4 TRP g 247  ALA g 251 -1  O  ALA g 251   N  ALA g 238           
SHEET    3 AC1 4 ILE g 256  ASP g 260 -1  O  LYS g 257   N  ALA g 250           
SHEET    4 AC1 4 ILE g 265  LEU g 270 -1  O  VAL g 267   N  ILE g 258           
SHEET    1 AC2 2 ILE A  38  ARG A  41  0                                        
SHEET    2 AC2 2 TYR A  47  ILE A  49 -1  O  ILE A  48   N  TYR A  39           
SHEET    1 AC3 5 THR A  97  ALA A 100  0                                        
SHEET    2 AC3 5 VAL A  74  SER A  78  1  N  VAL A  76   O  ILE A  99           
SHEET    3 AC3 5 LEU A 121  VAL A 124  1  O  VAL A 123   N  ILE A  77           
SHEET    4 AC3 5 THR A 144  CYS A 148  1  O  ILE A 145   N  LEU A 122           
SHEET    5 AC3 5 ILE A 159  PRO A 162  1  O  ILE A 161   N  ALA A 146           
SHEET    1 AC4 2 LYS B  28  LYS B  34  0                                        
SHEET    2 AC4 2 ASN B  43  THR B  50 -1  O  VAL B  49   N  ASP B  29           
SHEET    1 AC5 6 VAL B  66  SER B  70  0                                        
SHEET    2 AC5 6 ARG B  82  VAL B  91 -1  O  PHE B  84   N  VAL B  69           
SHEET    3 AC5 6 CYS B  96  LEU B 105 -1  O  ASN B  99   N  ILE B  87           
SHEET    4 AC5 6 LYS B 214  LYS B 219 -1  O  VAL B 215   N  MET B 103           
SHEET    5 AC5 6 LEU B 134  PHE B 142 -1  N  PHE B 138   O  LYS B 214           
SHEET    6 AC5 6 MET B 120  LYS B 128 -1  N  VAL B 127   O  LEU B 135           
SHEET    1 AC6 4 LEU C 102  THR C 116  0                                        
SHEET    2 AC6 4 GLY C 119  ASP C 132 -1  O  LYS C 125   N  MET C 110           
SHEET    3 AC6 4 HIS C 136  SER C 144 -1  O  LYS C 142   N  ALA C 126           
SHEET    4 AC6 4 VAL C 163  PRO C 164 -1  O  VAL C 163   N  VAL C 137           
SHEET    1 AC7 4 VAL C 184  CYS C 188  0                                        
SHEET    2 AC7 4 VAL C 191  PRO C 197 -1  O  VAL C 191   N  CYS C 188           
SHEET    3 AC7 4 CYS C 222  GLY C 228 -1  O  SER C 225   N  ARG C 194           
SHEET    4 AC7 4 ILE C 204  VAL C 205  1  N  VAL C 205   O  THR C 224           
SHEET    1 AC8 2 LEU E   9  LYS E  10  0                                        
SHEET    2 AC8 2 PHE E  27  ALA E  28 -1  O  ALA E  28   N  LEU E   9           
SHEET    1 AC9 2 LEU E  42  PRO E  43  0                                        
SHEET    2 AC9 2 PRO E  83  ALA E  84 -1  O  ALA E  84   N  LEU E  42           
SHEET    1 AD1 5 LYS E  75  VAL E  76  0                                        
SHEET    2 AD1 5 ILE E  70  ILE E  72 -1  N  ILE E  72   O  LYS E  75           
SHEET    3 AD1 5 ASP E  88  ILE E  92 -1  O  SER E  91   N  LYS E  71           
SHEET    4 AD1 5 GLU E  97  TYR E 103 -1  O  PHE E  99   N  ILE E  90           
SHEET    5 AD1 5 PHE E 109  ILE E 114 -1  O  HIS E 112   N  ARG E 100           
SHEET    1 AD2 5 THR E 146  ARG E 148  0                                        
SHEET    2 AD2 5 ILE E 136  THR E 141 -1  N  LEU E 139   O  ILE E 147           
SHEET    3 AD2 5 TYR E 121  GLY E 132 -1  N  PHE E 130   O  HIS E 138           
SHEET    4 AD2 5 THR E 159  ASP E 163 -1  O  ILE E 162   N  LYS E 122           
SHEET    5 AD2 5 LYS E 168  ILE E 173 -1  O  ASP E 171   N  GLN E 161           
SHEET    1 AD3 5 SER E 217  ARG E 221  0                                        
SHEET    2 AD3 5 VAL E 207  LYS E 211 -1  N  VAL E 210   O  PHE E 218           
SHEET    3 AD3 5 ILE E 192  ARG E 198 -1  N  VAL E 194   O  LYS E 211           
SHEET    4 AD3 5 ASN E 179  VAL E 183 -1  N  CYS E 181   O  GLY E 193           
SHEET    5 AD3 5 ILE E 225  LYS E 230 -1  O  ILE E 228   N  LEU E 180           
SHEET    1 AD4 5 CYS G  12  GLU G  17  0                                        
SHEET    2 AD4 5 LYS G   2  PHE G   7 -1  N  LEU G   3   O  ILE G  16           
SHEET    3 AD4 5 LEU G 106  LYS G 115  1  O  LEU G 111   N  SER G   6           
SHEET    4 AD4 5 VAL G  49  ASP G  57 -1  N  ASN G  56   O  SER G 107           
SHEET    5 AD4 5 GLU G  35  ALA G  37 -1  N  VAL G  36   O  VAL G  50           
SHEET    1 AD5 2 ARG G  72  LEU G  77  0                                        
SHEET    2 AD5 2 LYS G  93  ARG G  98 -1  O  LYS G  95   N  LEU G  75           
SHEET    1 AD6 2 LYS G 160  LEU G 162  0                                        
SHEET    2 AD6 2 ARG G 170  LYS G 172 -1  O  LYS G 172   N  LYS G 160           
SHEET    1 AD7 3 ALA H  47  GLU H  52  0                                        
SHEET    2 AD7 3 LYS H  58  VAL H  64 -1  O  ILE H  61   N  LYS H  49           
SHEET    3 AD7 3 LYS H  90  ALA H  96  1  O  HIS H  91   N  ILE H  60           
SHEET    1 AD8 6 ASP H 184  GLU H 188  0                                        
SHEET    2 AD8 6 ARG H 152  LEU H 158  1  N  ILE H 154   O  ASP H 184           
SHEET    3 AD8 6 ILE H 139  VAL H 146 -1  N  VAL H 140   O  HIS H 157           
SHEET    4 AD8 6 PHE W  50  ILE W  53 -1  O  PHE W  50   N  VAL H 146           
SHEET    5 AD8 6 LYS W  60  ASN W  64 -1  O  VAL W  62   N  GLU W  51           
SHEET    6 AD8 6 GLN W  24  ILE W  27 -1  N  ILE W  27   O  ILE W  61           
SHEET    1 AD9 2 ILE I   3  SER I   4  0                                        
SHEET    2 AD9 2 LEU I  29  GLY I  30 -1  O  GLY I  30   N  ILE I   3           
SHEET    1 AE1 3 LYS I  37  ILE I  38  0                                        
SHEET    2 AE1 3 LYS I  53  LEU I  60  1  O  LEU I  58   N  LYS I  37           
SHEET    3 AE1 3 ARG I  42  ARG I  47 -1  N  ARG I  42   O  LEU I  58           
SHEET    1 AE2 6 VAL I  62  TRP I  67  0                                        
SHEET    2 AE2 6 CYS I  72  TYR I  83 -1  O  CYS I  72   N  TRP I  67           
SHEET    3 AE2 6 ILE I 101  ASP I 105 -1  O  ILE I 101   N  VAL I  82           
SHEET    4 AE2 6 LYS I 170  ILE I 175 -1  O  ALA I 173   N  VAL I 102           
SHEET    5 AE2 6 GLY I 187  VAL I 189 -1  O  TYR I 188   N  CYS I 174           
SHEET    6 AE2 6 VAL I  62  TRP I  67  1  N  SER I  66   O  VAL I 189           
SHEET    1 AE3 2 ARG J 136  VAL J 137  0                                        
SHEET    2 AE3 2 GLN J 140  VAL J 141 -1  O  GLN J 140   N  VAL J 137           
SHEET    1 AE4 6 ILE L  72  MET L  82  0                                        
SHEET    2 AE4 6 THR L  85  ILE L  96 -1  O  VAL L  87   N  LYS L  79           
SHEET    3 AE4 6 ARG L 101  HIS L 112 -1  O  VAL L 111   N  ILE L  86           
SHEET    4 AE4 6 PHE L 140  THR L 146  1  O  VAL L 142   N  HIS L 112           
SHEET    5 AE4 6 ILE L 125  GLU L 130 -1  N  THR L 127   O  LEU L 143           
SHEET    6 AE4 6 ILE L  72  MET L  82 -1  N  GLY L  75   O  VAL L 126           
SHEET    1 AE5 5 THR O  52  THR O  57  0                                        
SHEET    2 AE5 5 THR O  40  THR O  45 -1  N  VAL O  44   O  ILE O  53           
SHEET    3 AE5 5 PHE O  28  ALA O  35 -1  N  VAL O  30   O  THR O  45           
SHEET    4 AE5 5 ALA O  92  ALA O  99  1  O  ARG O  98   N  ILE O  33           
SHEET    5 AE5 5 LYS O 125  ASP O 131  1  O  GLY O 127   N  LEU O  93           
SHEET    1 AE6 2 ILE V  32  VAL V  39  0                                        
SHEET    2 AE6 2 PHE V  46  ILE V  55 -1  O  TYR V  53   N  MET V  34           
SHEET    1 AE7 4 LYS W  71  VAL W  74  0                                        
SHEET    2 AE7 4 LYS W 124  PHE W 130 -1  O  PHE W 128   N  GLY W  73           
SHEET    3 AE7 4 PHE W 101  THR W 106 -1  N  PHE W 101   O  PHE W 129           
SHEET    4 AE7 4 GLY W 109  ASP W 112 -1  O  MET W 111   N  LEU W 104           
SHEET    1 AE8 7 VAL X 128  SER X 129  0                                        
SHEET    2 AE8 7 PHE X 120  VAL X 125 -1  N  VAL X 125   O  VAL X 128           
SHEET    3 AE8 7 GLU X  99  GLY X 104 -1  N  LEU X 101   O  VAL X 123           
SHEET    4 AE8 7 HIS X  46  GLU X  58 -1  N  GLY X  49   O  VAL X 100           
SHEET    5 AE8 7 ILE X  66  LEU X  74 -1  O  GLN X  73   N  ILE X  50           
SHEET    6 AE8 7 LYS X  80  PHE X  84 -1  O  ILE X  81   N  VAL X  72           
SHEET    7 AE8 7 PHE X 120  VAL X 125  1  O  PHE X 120   N  PHE X  84           
SHEET    1 AE9 4 THR Y   6  ASN Y  15  0                                        
SHEET    2 AE9 4 ARG Y  20  LEU Y  28 -1  O  ASP Y  26   N  ARG Y   8           
SHEET    3 AE9 4 LYS Y  68  TYR Y  76 -1  O  GLY Y  71   N  ILE Y  25           
SHEET    4 AE9 4 ILE Y  55  THR Y  62 -1  N  PHE Y  56   O  MET Y  74           
SHEET    1 AF1 3 ILE b  43  PHE b  47  0                                        
SHEET    2 AF1 3 PHE b  32  LYS b  36 -1  N  MET b  33   O  VAL b  46           
SHEET    3 AF1 3 SER b  78  ARG b  81 -1  O  SER b  78   N  LYS b  36           
SHEET    1 AF2 3 VAL b  54  LEU b  55  0                                        
SHEET    2 AF2 3 VAL b  62  GLN b  65 -1  O  LEU b  63   N  VAL b  54           
SHEET    3 AF2 3 ARG b  72  LEU b  73 -1  O  ARG b  72   N  GLN b  65           
SHEET    1 AF3 4 THR x  75  PRO x  79  0                                        
SHEET    2 AF3 4 ASN x 115  ARG x 119 -1  O  VAL x 116   N  ILE x  78           
SHEET    3 AF3 4 GLN x 106  ASN x 110 -1  N  GLN x 106   O  ARG x 119           
SHEET    4 AF3 4 PHE y 128  HIS y 129  1  O  HIS y 129   N  PHE x 109           
SHEET    1 AF4 3 PHE x 159  GLU x 164  0                                        
SHEET    2 AF4 3 LYS x 208  GLY x 213 -1  O  VAL x 209   N  PHE x 163           
SHEET    3 AF4 3 ARG x 201  ALA x 205 -1  N  VAL x 203   O  HIS x 210           
SHEET    1 AF5 2 VAL y   8  ALA y   9  0                                        
SHEET    2 AF5 2 CYS y 234  LEU y 235  1  O  LEU y 235   N  VAL y   8           
SHEET    1 AF6 2 TYR y  28  THR y  29  0                                        
SHEET    2 AF6 2 ARG y  54  PHE y  55  1  O  ARG y  54   N  THR y  29           
SHEET    1 AF7 5 LYS y 111  VAL y 112  0                                        
SHEET    2 AF7 5 LEU y 306  HIS y 309  1  O  LEU y 306   N  LYS y 111           
SHEET    3 AF7 5 LEU y 293  VAL y 300 -1  N  SER y 297   O  HIS y 309           
SHEET    4 AF7 5 ALA y 263  CYS y 270 -1  N  ILE y 267   O  VAL y 296           
SHEET    5 AF7 5 THR y 276  THR y 277 -1  O  THR y 277   N  LEU y 268           
SHEET    1 AF8 7 THR u 110  HIS u 112  0                                        
SHEET    2 AF8 7 MET u 123  CYS u 126 -1  O  LEU u 125   N  THR u 110           
SHEET    3 AF8 7 HIS u 131  SER u 137 -1  O  TRP u 133   N  LEU u 124           
SHEET    4 AF8 7 HIS u  83  PRO u  89  1  N  VAL u  87   O  THR u 136           
SHEET    5 AF8 7 THR u 155  LEU u 160  1  O  LEU u 157   N  LEU u  86           
SHEET    6 AF8 7 THR u 184  VAL u 189  1  O  THR u 184   N  ILE u 156           
SHEET    7 AF8 7 LEU u 220  LEU u 222  1  O  LEU u 221   N  LEU u 187           
SHEET    1 AF9 4 ALA u 251  PHE u 254  0                                        
SHEET    2 AF9 4 ILE u 580  SER u 583 -1  O  SER u 583   N  ALA u 251           
SHEET    3 AF9 4 LEU u 289  ILE u 291 -1  N  HIS u 290   O  PHE u 582           
SHEET    4 AF9 4 GLY u 295  PHE u 297 -1  O  PHE u 297   N  LEU u 289           
SHEET    1 AG1 5 ALA u 257  GLU u 264  0                                        
SHEET    2 AG1 5 VAL u 269  TYR u 277 -1  O  THR u 271   N  VAL u 261           
SHEET    3 AG1 5 TYR u 557  PRO u 566 -1  O  VAL u 558   N  GLY u 276           
SHEET    4 AG1 5 MET u 299  ASP u 303 -1  N  GLN u 301   O  HIS u 561           
SHEET    5 AG1 5 LEU u 344  ALA u 347 -1  O  LYS u 346   N  ILE u 302           
SHEET    1 AG2 2 PHE u 528  PHE u 530  0                                        
SHEET    2 AG2 2 GLN t 365  ILE t 367  1  O  ILE t 367   N  GLN u 529           
SHEET    1 AG3 7 PHE u 623  ALA u 625  0                                        
SHEET    2 AG3 7 LEU u 614  CYS u 618 -1  N  PHE u 616   O  PHE u 623           
SHEET    3 AG3 7 SER u 664  GLN u 670 -1  O  PHE u 668   N  ILE u 615           
SHEET    4 AG3 7 HIS u 676  LEU u 684 -1  O  ILE u 679   N  LEU u 667           
SHEET    5 AG3 7 MET u 591  ARG u 600 -1  N  VAL u 597   O  HIS u 683           
SHEET    6 AG3 7 ALA u 649  PRO u 657 -1  O  LEU u 650   N  VAL u 598           
SHEET    7 AG3 7 PHE u 629  GLN u 631 -1  N  SER u 630   O  VAL u 651           
SHEET    1 AG4 8 LYS u 637  LYS u 639  0                                        
SHEET    2 AG4 8 MET u 692  ILE u 706  1  O  ILE u 694   N  HIS u 638           
SHEET    3 AG4 8 VAL u 765  VAL u 773 -1  O  LYS u 771   N  LYS u 695           
SHEET    4 AG4 8 GLU u 730  THR u 733 -1  N  ARG u 732   O  LEU u 766           
SHEET    5 AG4 8 ARG u 738  PRO u 744 -1  O  GLY u 739   N  LEU u 731           
SHEET    6 AG4 8 HIS u 750  SER u 754 -1  O  LYS u 752   N  LYS u 742           
SHEET    7 AG4 8 MET u 710  ARG u 714 -1  N  ALA u 711   O  CYS u 753           
SHEET    8 AG4 8 MET u 692  ILE u 706 -1  N  LYS u 705   O  VAL u 712           
SHEET    1 AG5 2 ILE v  62  ARG v  66  0                                        
SHEET    2 AG5 2 GLN v  71  LEU v  75 -1  O  ARG v  74   N  ALA v  63           
SHEET    1 AG6 5 SER v  96  VAL v 103  0                                        
SHEET    2 AG6 5 SER v 107  ALA v 113 -1  O  ILE v 111   N  GLY v  98           
SHEET    3 AG6 5 GLN v 119  HIS v 125 -1  O  PHE v 120   N  VAL v 112           
SHEET    4 AG6 5 ALA v 185  MET v 188 -1  O  MET v 188   N  ALA v 121           
SHEET    5 AG6 5 ASP v 180  ASN v 182 -1  O  ASN v 182   N  ALA v 185           
SHEET    1 AG7 3 TYR v 194  PRO v 195  0                                        
SHEET    2 AG7 3 LEU v 234  ASP v 237 -1  O  LEU v 236   N  TYR v 194           
SHEET    3 AG7 3 HIS v 241  MET v 244 -1  O  THR v 243   N  ILE v 235           
SHEET    1 AG8 2 LEU v 224  ILE v 225  0                                        
SHEET    2 AG8 2 VAL v 251  SER v 252 -1  O  VAL v 251   N  ILE v 225           
LINK         O   CYS f 141                ZN    ZN f 200     1555   1555  2.44  
LINK         N   LYS f 143                ZN    ZN f 200     1555   1555  2.44  
LINK         N   CYS f 144                ZN    ZN f 200     1555   1555  2.63  
LINK         N   CYS f 145                ZN    ZN f 200     1555   1555  2.36  
LINK         SG  CYS y 270                ZN    ZN y 500     1555   1555  2.31  
LINK         SG  CYS y 273                ZN    ZN y 500     1555   1555  2.11  
LINK         SG  CYS y 285                ZN    ZN y 500     1555   1555  2.48  
LINK         SG  CYS y 288                ZN    ZN y 500     1555   1555  2.69  
CISPEP   1 ARG W   28    PRO W   29          0        -3.13                     
CISPEP   2 SER W   76    PRO W   77          0        10.19                     
CISPEP   3 PRO u  661    PRO u  662          0         4.76                     
CISPEP   4 ILE v  290    ARG v  291          0        -7.56                     
SITE     1 AC1  5 CYS f 141  GLY f 142  LYS f 143  CYS f 144                    
SITE     2 AC1  5 CYS f 145                                                     
SITE     1 AC2  4 CYS y 270  CYS y 273  CYS y 285  CYS y 288                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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