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Database: PDB
Entry: 6G2J
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Original site: 6G2J 
HEADER    OXIDOREDUCTASE                          23-MAR-18   6G2J              
TITLE     MOUSE MITOCHONDRIAL COMPLEX I IN THE ACTIVE STATE                     
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3;                    
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: NADH DEHYDROGENASE SUBUNIT 3;                               
COMPND   5 EC: 1.6.5.3;                                                         
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7,     
COMPND   8 MITOCHONDRIAL;                                                       
COMPND   9 CHAIN: B;                                                            
COMPND  10 SYNONYM: COMPLEX I-20KD,CI-20KD,NADH-UBIQUINONE OXIDOREDUCTASE 20 KDA
COMPND  11 SUBUNIT;                                                             
COMPND  12 EC: 1.6.5.3,1.6.99.3;                                                
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3,     
COMPND  15 MITOCHONDRIAL;                                                       
COMPND  16 CHAIN: C;                                                            
COMPND  17 SYNONYM: COMPLEX I-30KD,CI-30KD,NADH-UBIQUINONE OXIDOREDUCTASE 30 KDA
COMPND  18 SUBUNIT;                                                             
COMPND  19 EC: 1.6.5.3,1.6.99.3;                                                
COMPND  20 MOL_ID: 4;                                                           
COMPND  21 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2,     
COMPND  22 MITOCHONDRIAL;                                                       
COMPND  23 CHAIN: D;                                                            
COMPND  24 SYNONYM: COMPLEX I-49KD,CI-49KD,NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA
COMPND  25 SUBUNIT;                                                             
COMPND  26 EC: 1.6.5.3,1.6.99.3;                                                
COMPND  27 MOL_ID: 5;                                                           
COMPND  28 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2,            
COMPND  29 MITOCHONDRIAL;                                                       
COMPND  30 CHAIN: E;                                                            
COMPND  31 SYNONYM: NADH-UBIQUINONE OXIDOREDUCTASE 24 KDA SUBUNIT;              
COMPND  32 EC: 1.6.5.3,1.6.99.3;                                                
COMPND  33 MOL_ID: 6;                                                           
COMPND  34 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1,            
COMPND  35 MITOCHONDRIAL;                                                       
COMPND  36 CHAIN: F;                                                            
COMPND  37 SYNONYM: COMPLEX I-51KD,CI-51KD,NADH-UBIQUINONE OXIDOREDUCTASE 51 KDA
COMPND  38 SUBUNIT;                                                             
COMPND  39 EC: 1.6.5.3,1.6.99.3;                                                
COMPND  40 MOL_ID: 7;                                                           
COMPND  41 MOLECULE: NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT,             
COMPND  42 MITOCHONDRIAL;                                                       
COMPND  43 CHAIN: G;                                                            
COMPND  44 SYNONYM: COMPLEX I-75KD,CI-75KD;                                     
COMPND  45 EC: 1.6.5.3,1.6.99.3;                                                
COMPND  46 MOL_ID: 8;                                                           
COMPND  47 MOLECULE: NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1;                    
COMPND  48 CHAIN: H;                                                            
COMPND  49 SYNONYM: NADH DEHYDROGENASE SUBUNIT 1;                               
COMPND  50 EC: 1.6.5.3;                                                         
COMPND  51 MOL_ID: 9;                                                           
COMPND  52 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8,     
COMPND  53 MITOCHONDRIAL;                                                       
COMPND  54 CHAIN: I;                                                            
COMPND  55 SYNONYM: COMPLEX I-23KD,CI-23KD,NADH-UBIQUINONE OXIDOREDUCTASE 23 KDA
COMPND  56 SUBUNIT;                                                             
COMPND  57 EC: 1.6.5.3,1.6.99.3;                                                
COMPND  58 MOL_ID: 10;                                                          
COMPND  59 MOLECULE: NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6;                    
COMPND  60 CHAIN: J;                                                            
COMPND  61 SYNONYM: NADH DEHYDROGENASE SUBUNIT 6;                               
COMPND  62 EC: 1.6.5.3;                                                         
COMPND  63 MOL_ID: 11;                                                          
COMPND  64 MOLECULE: NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L;                   
COMPND  65 CHAIN: K;                                                            
COMPND  66 SYNONYM: NADH DEHYDROGENASE SUBUNIT 4L;                              
COMPND  67 EC: 1.6.5.3;                                                         
COMPND  68 MOL_ID: 12;                                                          
COMPND  69 MOLECULE: NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5;                    
COMPND  70 CHAIN: L;                                                            
COMPND  71 SYNONYM: NADH DEHYDROGENASE SUBUNIT 5;                               
COMPND  72 EC: 1.6.5.3;                                                         
COMPND  73 MOL_ID: 13;                                                          
COMPND  74 MOLECULE: NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4;                    
COMPND  75 CHAIN: M;                                                            
COMPND  76 SYNONYM: NADH DEHYDROGENASE SUBUNIT 4;                               
COMPND  77 EC: 1.6.5.3;                                                         
COMPND  78 MOL_ID: 14;                                                          
COMPND  79 MOLECULE: NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2;                    
COMPND  80 CHAIN: N;                                                            
COMPND  81 SYNONYM: NADH DEHYDROGENASE SUBUNIT 2;                               
COMPND  82 EC: 1.6.5.3;                                                         
COMPND  83 MOL_ID: 15;                                                          
COMPND  84 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND  85 10, MITOCHONDRIAL;                                                   
COMPND  86 CHAIN: O;                                                            
COMPND  87 SYNONYM: COMPLEX I-42KD,CI-42KD,NADH-UBIQUINONE OXIDOREDUCTASE 42 KDA
COMPND  88 SUBUNIT;                                                             
COMPND  89 MOL_ID: 16;                                                          
COMPND  90 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND  91 9, MITOCHONDRIAL;                                                    
COMPND  92 CHAIN: P;                                                            
COMPND  93 SYNONYM: COMPLEX I-39KD,CI-39KD,NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA
COMPND  94 SUBUNIT;                                                             
COMPND  95 MOL_ID: 17;                                                          
COMPND  96 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4,     
COMPND  97 MITOCHONDRIAL;                                                       
COMPND  98 CHAIN: Q;                                                            
COMPND  99 SYNONYM: COMPLEX I-18 KDA,CI-18 KDA,COMPLEX I-AQDQ,CI-AQDQ,NADH-     
COMPND 100 UBIQUINONE OXIDOREDUCTASE 18 KDA SUBUNIT;                            
COMPND 101 MOL_ID: 18;                                                          
COMPND 102 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6,     
COMPND 103 MITOCHONDRIAL;                                                       
COMPND 104 CHAIN: R;                                                            
COMPND 105 SYNONYM: COMPLEX I-13KD-A,CI-13KD-A,NADH-UBIQUINONE OXIDOREDUCTASE 13
COMPND 106 KDA-A SUBUNIT;                                                       
COMPND 107 MOL_ID: 19;                                                          
COMPND 108 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND 109 2;                                                                   
COMPND 110 CHAIN: S;                                                            
COMPND 111 SYNONYM: COMPLEX I-B8,CI-B8,NADH-UBIQUINONE OXIDOREDUCTASE B8        
COMPND 112 SUBUNIT;                                                             
COMPND 113 MOL_ID: 20;                                                          
COMPND 114 MOLECULE: ACYL CARRIER PROTEIN, MITOCHONDRIAL;                       
COMPND 115 CHAIN: T, U;                                                         
COMPND 116 SYNONYM: ACP,CI-SDAP,NADH-UBIQUINONE OXIDOREDUCTASE 9.6 KDA SUBUNIT; 
COMPND 117 MOL_ID: 21;                                                          
COMPND 118 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND 119 5;                                                                   
COMPND 120 CHAIN: V;                                                            
COMPND 121 SYNONYM: COMPLEX I SUBUNIT B13,COMPLEX I-13KD-B,CI-13KD-B,NADH-      
COMPND 122 UBIQUINONE OXIDOREDUCTASE 13 KDA-B SUBUNIT;                          
COMPND 123 MOL_ID: 22;                                                          
COMPND 124 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND 125 6;                                                                   
COMPND 126 CHAIN: W;                                                            
COMPND 127 SYNONYM: COMPLEX I-B14,CI-B14,NADH-UBIQUINONE OXIDOREDUCTASE B14     
COMPND 128 SUBUNIT;                                                             
COMPND 129 MOL_ID: 23;                                                          
COMPND 130 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND 131 8;                                                                   
COMPND 132 CHAIN: X;                                                            
COMPND 133 SYNONYM: COMPLEX I-19KD,CI-19KD,COMPLEX I-PGIV,CI-PGIV,NADH-         
COMPND 134 UBIQUINONE OXIDOREDUCTASE 19 KDA SUBUNIT;                            
COMPND 135 MOL_ID: 24;                                                          
COMPND 136 MOLECULE: MCG5603;                                                   
COMPND 137 CHAIN: Y;                                                            
COMPND 138 SYNONYM: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT  
COMPND 139 11;                                                                  
COMPND 140 MOL_ID: 25;                                                          
COMPND 141 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND 142 13;                                                                  
COMPND 143 CHAIN: Z;                                                            
COMPND 144 SYNONYM: CELL DEATH REGULATORY PROTEIN GRIM-19,COMPLEX I-B16.6,CI-   
COMPND 145 B16.6,GENE ASSOCIATED WITH RETINOIC AND INTERFERON-INDUCED MORTALITY 
COMPND 146 19 PROTEIN,GENE ASSOCIATED WITH RETINOIC AND IFN-INDUCED MORTALITY 19
COMPND 147 PROTEIN,NADH-UBIQUINONE OXIDOREDUCTASE B16.6 SUBUNIT;                
COMPND 148 MOL_ID: 26;                                                          
COMPND 149 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND 150 1;                                                                   
COMPND 151 CHAIN: a;                                                            
COMPND 152 SYNONYM: COMPLEX I-MWFE,CI-MWFE,NADH-UBIQUINONE OXIDOREDUCTASE MWFE  
COMPND 153 SUBUNIT;                                                             
COMPND 154 MOL_ID: 27;                                                          
COMPND 155 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND 156 3;                                                                   
COMPND 157 CHAIN: b;                                                            
COMPND 158 SYNONYM: COMPLEX I-B9,CI-B9,NADH-UBIQUINONE OXIDOREDUCTASE B9        
COMPND 159 SUBUNIT;                                                             
COMPND 160 MOL_ID: 28;                                                          
COMPND 161 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 SUBUNIT C1,              
COMPND 162 MITOCHONDRIAL;                                                       
COMPND 163 CHAIN: c;                                                            
COMPND 164 SYNONYM: COMPLEX I-KFYI,CI-KFYI,NADH-UBIQUINONE OXIDOREDUCTASE KFYI  
COMPND 165 SUBUNIT;                                                             
COMPND 166 MOL_ID: 29;                                                          
COMPND 167 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 SUBUNIT C2;              
COMPND 168 CHAIN: d;                                                            
COMPND 169 SYNONYM: COMPLEX I-B14.5B,CI-B14.5B,NADH-UBIQUINONE OXIDOREDUCTASE   
COMPND 170 SUBUNIT B14.5B;                                                      
COMPND 171 MOL_ID: 30;                                                          
COMPND 172 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5;     
COMPND 173 CHAIN: e;                                                            
COMPND 174 SYNONYM: COMPLEX I-15 KDA,CI-15 KDA,NADH-UBIQUINONE OXIDOREDUCTASE 15
COMPND 175 KDA SUBUNIT;                                                         
COMPND 176 MOL_ID: 31;                                                          
COMPND 177 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 178 1;                                                                   
COMPND 179 CHAIN: f;                                                            
COMPND 180 SYNONYM: COMPLEX I-MNLL,CI-MNLL,NADH-UBIQUINONE OXIDOREDUCTASE MNLL  
COMPND 181 SUBUNIT;                                                             
COMPND 182 MOL_ID: 32;                                                          
COMPND 183 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 184 11, MITOCHONDRIAL;                                                   
COMPND 185 CHAIN: g;                                                            
COMPND 186 SYNONYM: COMPLEX I-ESSS,CI-ESSS,NADH-UBIQUINONE OXIDOREDUCTASE ESSS  
COMPND 187 SUBUNIT,NEURONAL PROTEIN 15.6,P15.6;                                 
COMPND 188 MOL_ID: 33;                                                          
COMPND 189 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 190 5, MITOCHONDRIAL;                                                    
COMPND 191 CHAIN: h;                                                            
COMPND 192 SYNONYM: COMPLEX I-SGDH,CI-SGDH,NADH-UBIQUINONE OXIDOREDUCTASE SGDH  
COMPND 193 SUBUNIT;                                                             
COMPND 194 MOL_ID: 34;                                                          
COMPND 195 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 196 6;                                                                   
COMPND 197 CHAIN: i;                                                            
COMPND 198 SYNONYM: COMPLEX I-B17,CI-B17,NADH-UBIQUINONE OXIDOREDUCTASE B17     
COMPND 199 SUBUNIT;                                                             
COMPND 200 MOL_ID: 35;                                                          
COMPND 201 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 202 2, MITOCHONDRIAL;                                                    
COMPND 203 CHAIN: j;                                                            
COMPND 204 SYNONYM: COMPLEX I-AGGG,CI-AGGG,NADH-UBIQUINONE OXIDOREDUCTASE AGGG  
COMPND 205 SUBUNIT;                                                             
COMPND 206 MOL_ID: 36;                                                          
COMPND 207 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 208 3;                                                                   
COMPND 209 CHAIN: k;                                                            
COMPND 210 SYNONYM: COMPLEX I-B12,CI-B12,NADH-UBIQUINONE OXIDOREDUCTASE B12     
COMPND 211 SUBUNIT;                                                             
COMPND 212 MOL_ID: 37;                                                          
COMPND 213 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 214 8, MITOCHONDRIAL;                                                    
COMPND 215 CHAIN: l;                                                            
COMPND 216 SYNONYM: COMPLEX I-ASHI,CI-ASHI,NADH-UBIQUINONE OXIDOREDUCTASE ASHI  
COMPND 217 SUBUNIT;                                                             
COMPND 218 MOL_ID: 38;                                                          
COMPND 219 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 220 4;                                                                   
COMPND 221 CHAIN: m;                                                            
COMPND 222 SYNONYM: COMPLEX I-B15,CI-B15,NADH-UBIQUINONE OXIDOREDUCTASE B15     
COMPND 223 SUBUNIT;                                                             
COMPND 224 MOL_ID: 39;                                                          
COMPND 225 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 226 9;                                                                   
COMPND 227 CHAIN: n;                                                            
COMPND 228 SYNONYM: COMPLEX I-B22,CI-B22,NADH-UBIQUINONE OXIDOREDUCTASE B22     
COMPND 229 SUBUNIT;                                                             
COMPND 230 MOL_ID: 40;                                                          
COMPND 231 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 232 7;                                                                   
COMPND 233 CHAIN: o;                                                            
COMPND 234 SYNONYM: COMPLEX I-B18,CI-B18,NADH-UBIQUINONE OXIDOREDUCTASE B18     
COMPND 235 SUBUNIT;                                                             
COMPND 236 MOL_ID: 41;                                                          
COMPND 237 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT  
COMPND 238 10;                                                                  
COMPND 239 CHAIN: p;                                                            
COMPND 240 SYNONYM: COMPLEX I-PDSW,CI-PDSW,NADH-UBIQUINONE OXIDOREDUCTASE PDSW  
COMPND 241 SUBUNIT;                                                             
COMPND 242 MOL_ID: 42;                                                          
COMPND 243 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND 244 12;                                                                  
COMPND 245 CHAIN: q;                                                            
COMPND 246 SYNONYM: COMPLEX I-B17.2,CIB17.2,NADH-UBIQUINONE OXIDOREDUCTASE      
COMPND 247 SUBUNIT B17.2;                                                       
COMPND 248 MOL_ID: 43;                                                          
COMPND 249 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 
COMPND 250 7;                                                                   
COMPND 251 CHAIN: r;                                                            
COMPND 252 SYNONYM: COMPLEX I-B14.5A,CI-B14.5A,NADH-UBIQUINONE OXIDOREDUCTASE   
COMPND 253 SUBUNIT B14.5A;                                                      
COMPND 254 MOL_ID: 44;                                                          
COMPND 255 MOLECULE: NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 3,            
COMPND 256 MITOCHONDRIAL;                                                       
COMPND 257 CHAIN: s;                                                            
COMPND 258 SYNONYM: COMPLEX I-9KD,CI-9KD,NADH-UBIQUINONE OXIDOREDUCTASE 9 KDA   
COMPND 259 SUBUNIT                                                              
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE   3 ORGANISM_COMMON: MOUSE;                                              
SOURCE   4 ORGANISM_TAXID: 10090;                                               
SOURCE   5 ORGAN: HEART;                                                        
SOURCE   6 MOL_ID: 2;                                                           
SOURCE   7 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE   8 ORGANISM_COMMON: MOUSE;                                              
SOURCE   9 ORGANISM_TAXID: 10090;                                               
SOURCE  10 ORGAN: HEART;                                                        
SOURCE  11 MOL_ID: 3;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  13 ORGANISM_COMMON: MOUSE;                                              
SOURCE  14 ORGANISM_TAXID: 10090;                                               
SOURCE  15 ORGAN: HEART;                                                        
SOURCE  16 MOL_ID: 4;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  18 ORGANISM_COMMON: MOUSE;                                              
SOURCE  19 ORGANISM_TAXID: 10090;                                               
SOURCE  20 ORGAN: HEART;                                                        
SOURCE  21 MOL_ID: 5;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  23 ORGANISM_COMMON: MOUSE;                                              
SOURCE  24 ORGANISM_TAXID: 10090;                                               
SOURCE  25 ORGAN: HEART;                                                        
SOURCE  26 MOL_ID: 6;                                                           
SOURCE  27 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  28 ORGANISM_COMMON: MOUSE;                                              
SOURCE  29 ORGANISM_TAXID: 10090;                                               
SOURCE  30 ORGAN: HEART;                                                        
SOURCE  31 MOL_ID: 7;                                                           
SOURCE  32 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  33 ORGANISM_COMMON: MOUSE;                                              
SOURCE  34 ORGANISM_TAXID: 10090;                                               
SOURCE  35 ORGAN: HEART;                                                        
SOURCE  36 MOL_ID: 8;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  38 ORGANISM_COMMON: MOUSE;                                              
SOURCE  39 ORGANISM_TAXID: 10090;                                               
SOURCE  40 ORGAN: HEART;                                                        
SOURCE  41 MOL_ID: 9;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  43 ORGANISM_COMMON: MOUSE;                                              
SOURCE  44 ORGANISM_TAXID: 10090;                                               
SOURCE  45 ORGAN: HEART;                                                        
SOURCE  46 MOL_ID: 10;                                                          
SOURCE  47 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  48 ORGANISM_COMMON: MOUSE;                                              
SOURCE  49 ORGANISM_TAXID: 10090;                                               
SOURCE  50 ORGAN: HEART;                                                        
SOURCE  51 MOL_ID: 11;                                                          
SOURCE  52 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  53 ORGANISM_COMMON: MOUSE;                                              
SOURCE  54 ORGANISM_TAXID: 10090;                                               
SOURCE  55 ORGAN: HEART;                                                        
SOURCE  56 MOL_ID: 12;                                                          
SOURCE  57 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  58 ORGANISM_COMMON: MOUSE;                                              
SOURCE  59 ORGANISM_TAXID: 10090;                                               
SOURCE  60 ORGAN: HEART;                                                        
SOURCE  61 MOL_ID: 13;                                                          
SOURCE  62 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  63 ORGANISM_COMMON: MOUSE;                                              
SOURCE  64 ORGANISM_TAXID: 10090;                                               
SOURCE  65 ORGAN: HEART;                                                        
SOURCE  66 MOL_ID: 14;                                                          
SOURCE  67 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  68 ORGANISM_COMMON: MOUSE;                                              
SOURCE  69 ORGANISM_TAXID: 10090;                                               
SOURCE  70 ORGAN: HEART;                                                        
SOURCE  71 MOL_ID: 15;                                                          
SOURCE  72 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  73 ORGANISM_COMMON: MOUSE;                                              
SOURCE  74 ORGANISM_TAXID: 10090;                                               
SOURCE  75 ORGAN: HEART;                                                        
SOURCE  76 MOL_ID: 16;                                                          
SOURCE  77 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  78 ORGANISM_COMMON: MOUSE;                                              
SOURCE  79 ORGANISM_TAXID: 10090;                                               
SOURCE  80 ORGAN: HEART;                                                        
SOURCE  81 MOL_ID: 17;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  83 ORGANISM_COMMON: MOUSE;                                              
SOURCE  84 ORGANISM_TAXID: 10090;                                               
SOURCE  85 ORGAN: HEART;                                                        
SOURCE  86 MOL_ID: 18;                                                          
SOURCE  87 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  88 ORGANISM_COMMON: MOUSE;                                              
SOURCE  89 ORGANISM_TAXID: 10090;                                               
SOURCE  90 ORGAN: HEART;                                                        
SOURCE  91 MOL_ID: 19;                                                          
SOURCE  92 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  93 ORGANISM_COMMON: MOUSE;                                              
SOURCE  94 ORGANISM_TAXID: 10090;                                               
SOURCE  95 ORGAN: HEART;                                                        
SOURCE  96 MOL_ID: 20;                                                          
SOURCE  97 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  98 ORGANISM_COMMON: MOUSE;                                              
SOURCE  99 ORGANISM_TAXID: 10090;                                               
SOURCE 100 ORGAN: HEART;                                                        
SOURCE 101 MOL_ID: 21;                                                          
SOURCE 102 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 103 ORGANISM_COMMON: MOUSE;                                              
SOURCE 104 ORGANISM_TAXID: 10090;                                               
SOURCE 105 ORGAN: HEART;                                                        
SOURCE 106 MOL_ID: 22;                                                          
SOURCE 107 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 108 ORGANISM_COMMON: MOUSE;                                              
SOURCE 109 ORGANISM_TAXID: 10090;                                               
SOURCE 110 ORGAN: HEART;                                                        
SOURCE 111 MOL_ID: 23;                                                          
SOURCE 112 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 113 ORGANISM_COMMON: MOUSE;                                              
SOURCE 114 ORGANISM_TAXID: 10090;                                               
SOURCE 115 ORGAN: HEART;                                                        
SOURCE 116 MOL_ID: 24;                                                          
SOURCE 117 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 118 ORGANISM_COMMON: MOUSE;                                              
SOURCE 119 ORGANISM_TAXID: 10090;                                               
SOURCE 120 ORGAN: HEART;                                                        
SOURCE 121 MOL_ID: 25;                                                          
SOURCE 122 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 123 ORGANISM_COMMON: MOUSE;                                              
SOURCE 124 ORGANISM_TAXID: 10090;                                               
SOURCE 125 ORGAN: HEART;                                                        
SOURCE 126 MOL_ID: 26;                                                          
SOURCE 127 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 128 ORGANISM_COMMON: MOUSE;                                              
SOURCE 129 ORGANISM_TAXID: 10090;                                               
SOURCE 130 ORGAN: HEART;                                                        
SOURCE 131 MOL_ID: 27;                                                          
SOURCE 132 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 133 ORGANISM_COMMON: MOUSE;                                              
SOURCE 134 ORGANISM_TAXID: 10090;                                               
SOURCE 135 ORGAN: HEART;                                                        
SOURCE 136 MOL_ID: 28;                                                          
SOURCE 137 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 138 ORGANISM_COMMON: MOUSE;                                              
SOURCE 139 ORGANISM_TAXID: 10090;                                               
SOURCE 140 ORGAN: HEART;                                                        
SOURCE 141 MOL_ID: 29;                                                          
SOURCE 142 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 143 ORGANISM_COMMON: MOUSE;                                              
SOURCE 144 ORGANISM_TAXID: 10090;                                               
SOURCE 145 ORGAN: HEART;                                                        
SOURCE 146 MOL_ID: 30;                                                          
SOURCE 147 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 148 ORGANISM_COMMON: MOUSE;                                              
SOURCE 149 ORGANISM_TAXID: 10090;                                               
SOURCE 150 ORGAN: HEART;                                                        
SOURCE 151 MOL_ID: 31;                                                          
SOURCE 152 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 153 ORGANISM_COMMON: MOUSE;                                              
SOURCE 154 ORGANISM_TAXID: 10090;                                               
SOURCE 155 ORGAN: HEART;                                                        
SOURCE 156 MOL_ID: 32;                                                          
SOURCE 157 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 158 ORGANISM_COMMON: MOUSE;                                              
SOURCE 159 ORGANISM_TAXID: 10090;                                               
SOURCE 160 ORGAN: HEART;                                                        
SOURCE 161 MOL_ID: 33;                                                          
SOURCE 162 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 163 ORGANISM_COMMON: MOUSE;                                              
SOURCE 164 ORGANISM_TAXID: 10090;                                               
SOURCE 165 ORGAN: HEART;                                                        
SOURCE 166 MOL_ID: 34;                                                          
SOURCE 167 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 168 ORGANISM_COMMON: MOUSE;                                              
SOURCE 169 ORGANISM_TAXID: 10090;                                               
SOURCE 170 ORGAN: HEART;                                                        
SOURCE 171 MOL_ID: 35;                                                          
SOURCE 172 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 173 ORGANISM_COMMON: MOUSE;                                              
SOURCE 174 ORGANISM_TAXID: 10090;                                               
SOURCE 175 ORGAN: HEART;                                                        
SOURCE 176 MOL_ID: 36;                                                          
SOURCE 177 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 178 ORGANISM_COMMON: MOUSE;                                              
SOURCE 179 ORGANISM_TAXID: 10090;                                               
SOURCE 180 ORGAN: HEART;                                                        
SOURCE 181 MOL_ID: 37;                                                          
SOURCE 182 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 183 ORGANISM_COMMON: MOUSE;                                              
SOURCE 184 ORGANISM_TAXID: 10090;                                               
SOURCE 185 ORGAN: HEART;                                                        
SOURCE 186 MOL_ID: 38;                                                          
SOURCE 187 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 188 ORGANISM_COMMON: MOUSE;                                              
SOURCE 189 ORGANISM_TAXID: 10090;                                               
SOURCE 190 ORGAN: HEART;                                                        
SOURCE 191 MOL_ID: 39;                                                          
SOURCE 192 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 193 ORGANISM_COMMON: MOUSE;                                              
SOURCE 194 ORGANISM_TAXID: 10090;                                               
SOURCE 195 ORGAN: HEART;                                                        
SOURCE 196 MOL_ID: 40;                                                          
SOURCE 197 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 198 ORGANISM_COMMON: MOUSE;                                              
SOURCE 199 ORGANISM_TAXID: 10090;                                               
SOURCE 200 ORGAN: HEART;                                                        
SOURCE 201 MOL_ID: 41;                                                          
SOURCE 202 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 203 ORGANISM_COMMON: MOUSE;                                              
SOURCE 204 ORGANISM_TAXID: 10090;                                               
SOURCE 205 ORGAN: HEART;                                                        
SOURCE 206 MOL_ID: 42;                                                          
SOURCE 207 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 208 ORGANISM_COMMON: MOUSE;                                              
SOURCE 209 ORGANISM_TAXID: 10090;                                               
SOURCE 210 ORGAN: HEART;                                                        
SOURCE 211 MOL_ID: 43;                                                          
SOURCE 212 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 213 ORGANISM_COMMON: MOUSE;                                              
SOURCE 214 ORGANISM_TAXID: 10090;                                               
SOURCE 215 ORGAN: HEART;                                                        
SOURCE 216 MOL_ID: 44;                                                          
SOURCE 217 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE 218 ORGANISM_COMMON: MOUSE;                                              
SOURCE 219 ORGANISM_TAXID: 10090;                                               
SOURCE 220 ORGAN: HEART                                                         
KEYWDS    COMPLEX I, MITOCHONDRIA, PROTON PUMP, MEMBRANE PROTEIN,               
KEYWDS   2 OXIDOREDUCTASE                                                       
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    A.N.A.AGIP,J.N.BLAZA,H.R.BRIDGES,C.VISCOMI,S.RAWSON,S.P.MUENCH,       
AUTHOR   2 J.HIRST                                                              
REVDAT   3   01-AUG-18 6G2J    1       JRNL                                     
REVDAT   2   04-JUL-18 6G2J    1       JRNL                                     
REVDAT   1   06-JUN-18 6G2J    0                                                
JRNL        AUTH   A.A.AGIP,J.N.BLAZA,H.R.BRIDGES,C.VISCOMI,S.RAWSON,           
JRNL        AUTH 2 S.P.MUENCH,J.HIRST                                           
JRNL        TITL   CRYO-EM STRUCTURES OF COMPLEX I FROM MOUSE HEART             
JRNL        TITL 2 MITOCHONDRIA IN TWO BIOCHEMICALLY DEFINED STATES.            
JRNL        REF    NAT. STRUCT. MOL. BIOL.       V.  25   548 2018              
JRNL        REFN                   ESSN 1545-9985                               
JRNL        PMID   29915388                                                     
JRNL        DOI    10.1038/S41594-018-0073-1                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.30 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : EPU, GCTF, COOT, PHENIX, RELION,          
REMARK   3                            RELION, RELION, RELION                    
REMARK   3   RECONSTRUCTION SCHEMA  : FOURIER SPACE                             
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : USED DEFAULT PARAMTERES IN                       
REMARK   3  PHENIX.REAL_SPACE_REFINE                                            
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.300                          
REMARK   3   NUMBER OF PARTICLES               : 20370                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6G2J COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 23-MAR-18.                  
REMARK 100 THE DEPOSITION ID IS D_1200009148.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : MITOCHONDRIAL COMPLEX I FROM      
REMARK 245                                    MOUSE IN THE ACTIVE STATE         
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 5.00                              
REMARK 245   SAMPLE SUPPORT DETAILS         : GOLD WAS PEGYLATED PRIOR TO USE   
REMARK 245                                    IN ANAEROBIC ETHANOL IN 5MM SPT-  
REMARK 245                                    11P6 (SENSOPATH TECHNOLOGIES)     
REMARK 245                                    FOR TWO DAYS 0.6/1 HOLES          
REMARK 245   SAMPLE VITRIFICATION DETAILS   : 8-16S BLOTTING.                   
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.14                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 QUANTUM (4K X 4K)     
REMARK 245   MINIMUM DEFOCUS (NM)              : 1500.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3100.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 50.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : 47600                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 45-MERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 45-MERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 305830 ANGSTROM**2                        
REMARK 350 SURFACE AREA OF THE COMPLEX: 263380 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -2054.0 KCAL/MOL                      
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N, O, P, Q, R, S,            
REMARK 350                    AND CHAINS: T, U, V, W, X, Y, Z, a, b, c,         
REMARK 350                    AND CHAINS: d, e, f, g, h, i, j, k, l,            
REMARK 350                    AND CHAINS: m, n, o, p, q, r, s                   
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET B   -34                                                      
REMARK 465     ALA B   -33                                                      
REMARK 465     ALA B   -32                                                      
REMARK 465     LEU B   -31                                                      
REMARK 465     ALA B   -30                                                      
REMARK 465     ALA B   -29                                                      
REMARK 465     PRO B   -28                                                      
REMARK 465     GLY B   -27                                                      
REMARK 465     LEU B   -26                                                      
REMARK 465     LEU B   -25                                                      
REMARK 465     SER B   -24                                                      
REMARK 465     VAL B   -23                                                      
REMARK 465     ARG B   -22                                                      
REMARK 465     ILE B   -21                                                      
REMARK 465     LEU B   -20                                                      
REMARK 465     GLY B   -19                                                      
REMARK 465     LEU B   -18                                                      
REMARK 465     ARG B   -17                                                      
REMARK 465     THR B   -16                                                      
REMARK 465     ALA B   -15                                                      
REMARK 465     GLN B   -14                                                      
REMARK 465     VAL B   -13                                                      
REMARK 465     GLN B   -12                                                      
REMARK 465     LEU B   -11                                                      
REMARK 465     ARG B   -10                                                      
REMARK 465     ARG B    -9                                                      
REMARK 465     VAL B    -8                                                      
REMARK 465     HIS B    -7                                                      
REMARK 465     GLN B    -6                                                      
REMARK 465     SER B    -5                                                      
REMARK 465     VAL B    -4                                                      
REMARK 465     ALA B    -3                                                      
REMARK 465     THR B    -2                                                      
REMARK 465     GLU B    -1                                                      
REMARK 465     GLY B     0                                                      
REMARK 465     PRO B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     PRO B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     PRO B     5                                                      
REMARK 465     SER B     6                                                      
REMARK 465     PRO B     7                                                      
REMARK 465     SER B     8                                                      
REMARK 465     LEU B     9                                                      
REMARK 465     SER B    10                                                      
REMARK 465     SER B    11                                                      
REMARK 465     THR B    12                                                      
REMARK 465     GLN B    13                                                      
REMARK 465     SER B    14                                                      
REMARK 465     ALA B    15                                                      
REMARK 465     VAL B    16                                                      
REMARK 465     SER B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     ALA B    19                                                      
REMARK 465     GLY B    20                                                      
REMARK 465     ALA B    21                                                      
REMARK 465     GLY B    22                                                      
REMARK 465     ALA B    23                                                      
REMARK 465     VAL B    24                                                      
REMARK 465     VAL B    25                                                      
REMARK 465     PRO B    26                                                      
REMARK 465     LYS B    27                                                      
REMARK 465     LEU B    28                                                      
REMARK 465     SER B    29                                                      
REMARK 465     HIS B    30                                                      
REMARK 465     LEU B    31                                                      
REMARK 465     PRO B    32                                                      
REMARK 465     ARG B    33                                                      
REMARK 465     SER B    34                                                      
REMARK 465     MET C   -34                                                      
REMARK 465     ALA C   -33                                                      
REMARK 465     ALA C   -32                                                      
REMARK 465     ALA C   -31                                                      
REMARK 465     ALA C   -30                                                      
REMARK 465     ALA C   -29                                                      
REMARK 465     ARG C   -28                                                      
REMARK 465     VAL C   -27                                                      
REMARK 465     TRP C   -26                                                      
REMARK 465     CYS C   -25                                                      
REMARK 465     ARG C   -24                                                      
REMARK 465     GLY C   -23                                                      
REMARK 465     LEU C   -22                                                      
REMARK 465     LEU C   -21                                                      
REMARK 465     GLY C   -20                                                      
REMARK 465     ALA C   -19                                                      
REMARK 465     ALA C   -18                                                      
REMARK 465     SER C   -17                                                      
REMARK 465     VAL C   -16                                                      
REMARK 465     GLY C   -15                                                      
REMARK 465     ARG C   -14                                                      
REMARK 465     GLY C   -13                                                      
REMARK 465     ALA C   -12                                                      
REMARK 465     GLY C   -11                                                      
REMARK 465     ARG C   -10                                                      
REMARK 465     PRO C    -9                                                      
REMARK 465     SER C    -8                                                      
REMARK 465     VAL C    -7                                                      
REMARK 465     LEU C    -6                                                      
REMARK 465     TRP C    -5                                                      
REMARK 465     GLN C    -4                                                      
REMARK 465     HIS C    -3                                                      
REMARK 465     VAL C    -2                                                      
REMARK 465     ARG C    -1                                                      
REMARK 465     ARG C     0                                                      
REMARK 465     GLU C     1                                                      
REMARK 465     SER C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     ALA C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     ASP C     6                                                      
REMARK 465     LYS C     7                                                      
REMARK 465     GLU C   214                                                      
REMARK 465     SER C   215                                                      
REMARK 465     LEU C   216                                                      
REMARK 465     LYS C   217                                                      
REMARK 465     LEU C   218                                                      
REMARK 465     GLU C   219                                                      
REMARK 465     ALA C   220                                                      
REMARK 465     GLY C   221                                                      
REMARK 465     ASP C   222                                                      
REMARK 465     LYS C   223                                                      
REMARK 465     LYS C   224                                                      
REMARK 465     PRO C   225                                                      
REMARK 465     GLU C   226                                                      
REMARK 465     THR C   227                                                      
REMARK 465     LYS C   228                                                      
REMARK 465     MET D   -32                                                      
REMARK 465     ALA D   -31                                                      
REMARK 465     ALA D   -30                                                      
REMARK 465     LEU D   -29                                                      
REMARK 465     ARG D   -28                                                      
REMARK 465     ALA D   -27                                                      
REMARK 465     LEU D   -26                                                      
REMARK 465     ARG D   -25                                                      
REMARK 465     CYS D   -24                                                      
REMARK 465     LEU D   -23                                                      
REMARK 465     ARG D   -22                                                      
REMARK 465     GLY D   -21                                                      
REMARK 465     VAL D   -20                                                      
REMARK 465     GLY D   -19                                                      
REMARK 465     ALA D   -18                                                      
REMARK 465     PRO D   -17                                                      
REMARK 465     VAL D   -16                                                      
REMARK 465     LEU D   -15                                                      
REMARK 465     ARG D   -14                                                      
REMARK 465     PRO D   -13                                                      
REMARK 465     GLY D   -12                                                      
REMARK 465     SER D   -11                                                      
REMARK 465     GLY D   -10                                                      
REMARK 465     ILE D    -9                                                      
REMARK 465     ARG D    -8                                                      
REMARK 465     LEU D    -7                                                      
REMARK 465     PRO D    -6                                                      
REMARK 465     SER D    -5                                                      
REMARK 465     GLN D    -4                                                      
REMARK 465     PRO D    -3                                                      
REMARK 465     SER D    -2                                                      
REMARK 465     ARG D    -1                                                      
REMARK 465     GLY D     0                                                      
REMARK 465     MET E   -30                                                      
REMARK 465     PHE E   -29                                                      
REMARK 465     SER E   -28                                                      
REMARK 465     LEU E   -27                                                      
REMARK 465     ALA E   -26                                                      
REMARK 465     LEU E   -25                                                      
REMARK 465     ARG E   -24                                                      
REMARK 465     ALA E   -23                                                      
REMARK 465     ARG E   -22                                                      
REMARK 465     ALA E   -21                                                      
REMARK 465     THR E   -20                                                      
REMARK 465     GLY E   -19                                                      
REMARK 465     LEU E   -18                                                      
REMARK 465     ALA E   -17                                                      
REMARK 465     ALA E   -16                                                      
REMARK 465     GLN E   -15                                                      
REMARK 465     TRP E   -14                                                      
REMARK 465     GLY E   -13                                                      
REMARK 465     ARG E   -12                                                      
REMARK 465     HIS E   -11                                                      
REMARK 465     ALA E   -10                                                      
REMARK 465     ARG E    -9                                                      
REMARK 465     ASN E    -8                                                      
REMARK 465     LEU E    -7                                                      
REMARK 465     HIS E    -6                                                      
REMARK 465     LYS E    -5                                                      
REMARK 465     THR E    -4                                                      
REMARK 465     ALA E    -3                                                      
REMARK 465     VAL E    -2                                                      
REMARK 465     HIS E    -1                                                      
REMARK 465     ASN E     0                                                      
REMARK 465     GLY E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     GLY E     3                                                      
REMARK 465     GLY E     4                                                      
REMARK 465     LEU E   217                                                      
REMARK 465     MET G   -22                                                      
REMARK 465     LEU G   -21                                                      
REMARK 465     ARG G   -20                                                      
REMARK 465     ILE G   -19                                                      
REMARK 465     PRO G   -18                                                      
REMARK 465     ILE G   -17                                                      
REMARK 465     LYS G   -16                                                      
REMARK 465     ARG G   -15                                                      
REMARK 465     ALA G   -14                                                      
REMARK 465     LEU G   -13                                                      
REMARK 465     ILE G   -12                                                      
REMARK 465     GLY G   -11                                                      
REMARK 465     LEU G   -10                                                      
REMARK 465     SER G    -9                                                      
REMARK 465     ASN G    -8                                                      
REMARK 465     SER G    -7                                                      
REMARK 465     PRO G    -6                                                      
REMARK 465     LYS G    -5                                                      
REMARK 465     GLY G    -4                                                      
REMARK 465     TYR G    -3                                                      
REMARK 465     VAL G    -2                                                      
REMARK 465     ARG G    -1                                                      
REMARK 465     THR G     0                                                      
REMARK 465     THR G     1                                                      
REMARK 465     GLY G     2                                                      
REMARK 465     THR G     3                                                      
REMARK 465     ALA G     4                                                      
REMARK 465     ALA G     5                                                      
REMARK 465     GLY G   694                                                      
REMARK 465     ALA G   695                                                      
REMARK 465     GLN G   696                                                      
REMARK 465     ALA G   697                                                      
REMARK 465     VAL G   698                                                      
REMARK 465     GLU G   699                                                      
REMARK 465     GLU G   700                                                      
REMARK 465     PRO G   701                                                      
REMARK 465     SER G   702                                                      
REMARK 465     ILE G   703                                                      
REMARK 465     CYS G   704                                                      
REMARK 465     MET I   -33                                                      
REMARK 465     TYR I   -32                                                      
REMARK 465     ARG I   -31                                                      
REMARK 465     LEU I   -30                                                      
REMARK 465     SER I   -29                                                      
REMARK 465     SER I   -28                                                      
REMARK 465     SER I   -27                                                      
REMARK 465     MET I   -26                                                      
REMARK 465     LEU I   -25                                                      
REMARK 465     PRO I   -24                                                      
REMARK 465     ARG I   -23                                                      
REMARK 465     ALA I   -22                                                      
REMARK 465     LEU I   -21                                                      
REMARK 465     ALA I   -20                                                      
REMARK 465     GLN I   -19                                                      
REMARK 465     ALA I   -18                                                      
REMARK 465     MET I   -17                                                      
REMARK 465     ARG I   -16                                                      
REMARK 465     THR I   -15                                                      
REMARK 465     GLY I   -14                                                      
REMARK 465     HIS I   -13                                                      
REMARK 465     LEU I   -12                                                      
REMARK 465     ASN I   -11                                                      
REMARK 465     GLY I   -10                                                      
REMARK 465     GLN I    -9                                                      
REMARK 465     SER I    -8                                                      
REMARK 465     LEU I    -7                                                      
REMARK 465     HIS I    -6                                                      
REMARK 465     SER I    -5                                                      
REMARK 465     SER I    -4                                                      
REMARK 465     ALA I    -3                                                      
REMARK 465     VAL I    -2                                                      
REMARK 465     ALA I    -1                                                      
REMARK 465     ALA I     0                                                      
REMARK 465     ASP J   172                                                      
REMARK 465     GLU L   607                                                      
REMARK 465     THR N   345                                                      
REMARK 465     MET O   -34                                                      
REMARK 465     ALA O   -33                                                      
REMARK 465     LEU O   -32                                                      
REMARK 465     ARG O   -31                                                      
REMARK 465     LEU O   -30                                                      
REMARK 465     LEU O   -29                                                      
REMARK 465     ARG O   -28                                                      
REMARK 465     LEU O   -27                                                      
REMARK 465     VAL O   -26                                                      
REMARK 465     PRO O   -25                                                      
REMARK 465     ALA O   -24                                                      
REMARK 465     SER O   -23                                                      
REMARK 465     ALA O   -22                                                      
REMARK 465     PRO O   -21                                                      
REMARK 465     ALA O   -20                                                      
REMARK 465     ARG O   -19                                                      
REMARK 465     GLY O   -18                                                      
REMARK 465     LEU O   -17                                                      
REMARK 465     ALA O   -16                                                      
REMARK 465     ALA O   -15                                                      
REMARK 465     GLY O   -14                                                      
REMARK 465     ALA O   -13                                                      
REMARK 465     GLN O   -12                                                      
REMARK 465     ARG O   -11                                                      
REMARK 465     VAL O   -10                                                      
REMARK 465     GLY O    -9                                                      
REMARK 465     ARG O    -8                                                      
REMARK 465     ILE O    -7                                                      
REMARK 465     HIS O    -6                                                      
REMARK 465     THR O    -5                                                      
REMARK 465     SER O    -4                                                      
REMARK 465     VAL O    -3                                                      
REMARK 465     HIS O    -2                                                      
REMARK 465     CYS O    -1                                                      
REMARK 465     LYS O     0                                                      
REMARK 465     MET P   -34                                                      
REMARK 465     ALA P   -33                                                      
REMARK 465     ALA P   -32                                                      
REMARK 465     ALA P   -31                                                      
REMARK 465     VAL P   -30                                                      
REMARK 465     ARG P   -29                                                      
REMARK 465     PHE P   -28                                                      
REMARK 465     ARG P   -27                                                      
REMARK 465     VAL P   -26                                                      
REMARK 465     VAL P   -25                                                      
REMARK 465     ARG P   -24                                                      
REMARK 465     ALA P   -23                                                      
REMARK 465     LEU P   -22                                                      
REMARK 465     PRO P   -21                                                      
REMARK 465     MET P   -20                                                      
REMARK 465     SER P   -19                                                      
REMARK 465     ARG P   -18                                                      
REMARK 465     PRO P   -17                                                      
REMARK 465     ALA P   -16                                                      
REMARK 465     ILE P   -15                                                      
REMARK 465     THR P   -14                                                      
REMARK 465     ALA P   -13                                                      
REMARK 465     ALA P   -12                                                      
REMARK 465     ALA P   -11                                                      
REMARK 465     THR P   -10                                                      
REMARK 465     SER P    -9                                                      
REMARK 465     VAL P    -8                                                      
REMARK 465     PHE P    -7                                                      
REMARK 465     CYS P    -6                                                      
REMARK 465     GLY P    -5                                                      
REMARK 465     SER P    -4                                                      
REMARK 465     SER P    -3                                                      
REMARK 465     HIS P    -2                                                      
REMARK 465     ARG P    -1                                                      
REMARK 465     GLN P     0                                                      
REMARK 465     MET Q   -41                                                      
REMARK 465     ALA Q   -40                                                      
REMARK 465     ALA Q   -39                                                      
REMARK 465     VAL Q   -38                                                      
REMARK 465     SER Q   -37                                                      
REMARK 465     ILE Q   -36                                                      
REMARK 465     SER Q   -35                                                      
REMARK 465     VAL Q   -34                                                      
REMARK 465     SER Q   -33                                                      
REMARK 465     LEU Q   -32                                                      
REMARK 465     ARG Q   -31                                                      
REMARK 465     GLN Q   -30                                                      
REMARK 465     ALA Q   -29                                                      
REMARK 465     MET Q   -28                                                      
REMARK 465     LEU Q   -27                                                      
REMARK 465     GLY Q   -26                                                      
REMARK 465     ARG Q   -25                                                      
REMARK 465     ARG Q   -24                                                      
REMARK 465     ALA Q   -23                                                      
REMARK 465     MET Q   -22                                                      
REMARK 465     ALA Q   -21                                                      
REMARK 465     THR Q   -20                                                      
REMARK 465     ALA Q   -19                                                      
REMARK 465     ALA Q   -18                                                      
REMARK 465     VAL Q   -17                                                      
REMARK 465     SER Q   -16                                                      
REMARK 465     VAL Q   -15                                                      
REMARK 465     CYS Q   -14                                                      
REMARK 465     ARG Q   -13                                                      
REMARK 465     VAL Q   -12                                                      
REMARK 465     PRO Q   -11                                                      
REMARK 465     SER Q   -10                                                      
REMARK 465     ARG Q    -9                                                      
REMARK 465     LEU Q    -8                                                      
REMARK 465     LEU Q    -7                                                      
REMARK 465     SER Q    -6                                                      
REMARK 465     THR Q    -5                                                      
REMARK 465     SER Q    -4                                                      
REMARK 465     THR Q    -3                                                      
REMARK 465     TRP Q    -2                                                      
REMARK 465     LYS Q    -1                                                      
REMARK 465     LEU Q     0                                                      
REMARK 465     ALA Q     1                                                      
REMARK 465     ASP Q     2                                                      
REMARK 465     ASN Q     3                                                      
REMARK 465     GLN Q     4                                                      
REMARK 465     THR Q     5                                                      
REMARK 465     ARG Q     6                                                      
REMARK 465     ASP Q     7                                                      
REMARK 465     THR Q     8                                                      
REMARK 465     MET R   -19                                                      
REMARK 465     ALA R   -18                                                      
REMARK 465     ALA R   -17                                                      
REMARK 465     VAL R   -16                                                      
REMARK 465     LEU R   -15                                                      
REMARK 465     THR R   -14                                                      
REMARK 465     PHE R   -13                                                      
REMARK 465     ARG R   -12                                                      
REMARK 465     ARG R   -11                                                      
REMARK 465     LEU R   -10                                                      
REMARK 465     LEU R    -9                                                      
REMARK 465     THR R    -8                                                      
REMARK 465     LEU R    -7                                                      
REMARK 465     PRO R    -6                                                      
REMARK 465     ARG R    -5                                                      
REMARK 465     ALA R    -4                                                      
REMARK 465     ALA R    -3                                                      
REMARK 465     ARG R    -2                                                      
REMARK 465     GLY R    -1                                                      
REMARK 465     PHE R     0                                                      
REMARK 465     HIS R    96                                                      
REMARK 465     MET S     0                                                      
REMARK 465     ALA S     1                                                      
REMARK 465     ALA S     2                                                      
REMARK 465     ALA S     3                                                      
REMARK 465     ALA S     4                                                      
REMARK 465     ALA S     5                                                      
REMARK 465     SER S     6                                                      
REMARK 465     ARG S     7                                                      
REMARK 465     ALA S     8                                                      
REMARK 465     VAL S     9                                                      
REMARK 465     GLY S    10                                                      
REMARK 465     ALA S    11                                                      
REMARK 465     LYS S    12                                                      
REMARK 465     GLY S    96                                                      
REMARK 465     LYS S    97                                                      
REMARK 465     ALA S    98                                                      
REMARK 465     MET T   -67                                                      
REMARK 465     ALA T   -66                                                      
REMARK 465     SER T   -65                                                      
REMARK 465     ARG T   -64                                                      
REMARK 465     VAL T   -63                                                      
REMARK 465     LEU T   -62                                                      
REMARK 465     CYS T   -61                                                      
REMARK 465     ALA T   -60                                                      
REMARK 465     CYS T   -59                                                      
REMARK 465     VAL T   -58                                                      
REMARK 465     ARG T   -57                                                      
REMARK 465     ARG T   -56                                                      
REMARK 465     LEU T   -55                                                      
REMARK 465     PRO T   -54                                                      
REMARK 465     ALA T   -53                                                      
REMARK 465     ALA T   -52                                                      
REMARK 465     PHE T   -51                                                      
REMARK 465     ALA T   -50                                                      
REMARK 465     PRO T   -49                                                      
REMARK 465     LEU T   -48                                                      
REMARK 465     PRO T   -47                                                      
REMARK 465     ARG T   -46                                                      
REMARK 465     LEU T   -45                                                      
REMARK 465     PRO T   -44                                                      
REMARK 465     THR T   -43                                                      
REMARK 465     LEU T   -42                                                      
REMARK 465     ALA T   -41                                                      
REMARK 465     LEU T   -40                                                      
REMARK 465     ALA T   -39                                                      
REMARK 465     ARG T   -38                                                      
REMARK 465     PRO T   -37                                                      
REMARK 465     LEU T   -36                                                      
REMARK 465     SER T   -35                                                      
REMARK 465     THR T   -34                                                      
REMARK 465     THR T   -33                                                      
REMARK 465     LEU T   -32                                                      
REMARK 465     CYS T   -31                                                      
REMARK 465     PRO T   -30                                                      
REMARK 465     GLU T   -29                                                      
REMARK 465     GLY T   -28                                                      
REMARK 465     ILE T   -27                                                      
REMARK 465     ARG T   -26                                                      
REMARK 465     ARG T   -25                                                      
REMARK 465     ARG T   -24                                                      
REMARK 465     PRO T   -23                                                      
REMARK 465     GLY T   -22                                                      
REMARK 465     ALA T   -21                                                      
REMARK 465     LEU T   -20                                                      
REMARK 465     GLN T   -19                                                      
REMARK 465     SER T   -18                                                      
REMARK 465     ALA T   -17                                                      
REMARK 465     LEU T   -16                                                      
REMARK 465     ALA T   -15                                                      
REMARK 465     LEU T   -14                                                      
REMARK 465     ALA T   -13                                                      
REMARK 465     GLN T   -12                                                      
REMARK 465     VAL T   -11                                                      
REMARK 465     PRO T   -10                                                      
REMARK 465     GLY T    -9                                                      
REMARK 465     THR T    -8                                                      
REMARK 465     VAL T    -7                                                      
REMARK 465     THR T    -6                                                      
REMARK 465     HIS T    -5                                                      
REMARK 465     LEU T    -4                                                      
REMARK 465     CYS T    -3                                                      
REMARK 465     ARG T    -2                                                      
REMARK 465     GLN T    -1                                                      
REMARK 465     TYR T     0                                                      
REMARK 465     SER T     1                                                      
REMARK 465     ASP T     2                                                      
REMARK 465     ALA T     3                                                      
REMARK 465     PRO T     4                                                      
REMARK 465     PRO T     5                                                      
REMARK 465     LEU T     6                                                      
REMARK 465     THR T     7                                                      
REMARK 465     LYS T    83                                                      
REMARK 465     LYS T    84                                                      
REMARK 465     ASP T    85                                                      
REMARK 465     VAL T    86                                                      
REMARK 465     TYR T    87                                                      
REMARK 465     GLU T    88                                                      
REMARK 465     MET U   -67                                                      
REMARK 465     ALA U   -66                                                      
REMARK 465     SER U   -65                                                      
REMARK 465     ARG U   -64                                                      
REMARK 465     VAL U   -63                                                      
REMARK 465     LEU U   -62                                                      
REMARK 465     CYS U   -61                                                      
REMARK 465     ALA U   -60                                                      
REMARK 465     CYS U   -59                                                      
REMARK 465     VAL U   -58                                                      
REMARK 465     ARG U   -57                                                      
REMARK 465     ARG U   -56                                                      
REMARK 465     LEU U   -55                                                      
REMARK 465     PRO U   -54                                                      
REMARK 465     ALA U   -53                                                      
REMARK 465     ALA U   -52                                                      
REMARK 465     PHE U   -51                                                      
REMARK 465     ALA U   -50                                                      
REMARK 465     PRO U   -49                                                      
REMARK 465     LEU U   -48                                                      
REMARK 465     PRO U   -47                                                      
REMARK 465     ARG U   -46                                                      
REMARK 465     LEU U   -45                                                      
REMARK 465     PRO U   -44                                                      
REMARK 465     THR U   -43                                                      
REMARK 465     LEU U   -42                                                      
REMARK 465     ALA U   -41                                                      
REMARK 465     LEU U   -40                                                      
REMARK 465     ALA U   -39                                                      
REMARK 465     ARG U   -38                                                      
REMARK 465     PRO U   -37                                                      
REMARK 465     LEU U   -36                                                      
REMARK 465     SER U   -35                                                      
REMARK 465     THR U   -34                                                      
REMARK 465     THR U   -33                                                      
REMARK 465     LEU U   -32                                                      
REMARK 465     CYS U   -31                                                      
REMARK 465     PRO U   -30                                                      
REMARK 465     GLU U   -29                                                      
REMARK 465     GLY U   -28                                                      
REMARK 465     ILE U   -27                                                      
REMARK 465     ARG U   -26                                                      
REMARK 465     ARG U   -25                                                      
REMARK 465     ARG U   -24                                                      
REMARK 465     PRO U   -23                                                      
REMARK 465     GLY U   -22                                                      
REMARK 465     ALA U   -21                                                      
REMARK 465     LEU U   -20                                                      
REMARK 465     GLN U   -19                                                      
REMARK 465     SER U   -18                                                      
REMARK 465     ALA U   -17                                                      
REMARK 465     LEU U   -16                                                      
REMARK 465     ALA U   -15                                                      
REMARK 465     LEU U   -14                                                      
REMARK 465     ALA U   -13                                                      
REMARK 465     GLN U   -12                                                      
REMARK 465     VAL U   -11                                                      
REMARK 465     PRO U   -10                                                      
REMARK 465     GLY U    -9                                                      
REMARK 465     THR U    -8                                                      
REMARK 465     VAL U    -7                                                      
REMARK 465     THR U    -6                                                      
REMARK 465     HIS U    -5                                                      
REMARK 465     LEU U    -4                                                      
REMARK 465     CYS U    -3                                                      
REMARK 465     ARG U    -2                                                      
REMARK 465     GLN U    -1                                                      
REMARK 465     TYR U     0                                                      
REMARK 465     MET V     0                                                      
REMARK 465     ALA V     1                                                      
REMARK 465     GLY V     2                                                      
REMARK 465     LEU V     3                                                      
REMARK 465     MET W     0                                                      
REMARK 465     ALA W     1                                                      
REMARK 465     ALA W     2                                                      
REMARK 465     ALA W     3                                                      
REMARK 465     ALA W     4                                                      
REMARK 465     THR W     5                                                      
REMARK 465     GLY W     6                                                      
REMARK 465     LEU W     7                                                      
REMARK 465     ARG W     8                                                      
REMARK 465     GLN W     9                                                      
REMARK 465     ALA W    10                                                      
REMARK 465     ALA W    11                                                      
REMARK 465     ALA W    12                                                      
REMARK 465     ALA W    13                                                      
REMARK 465     ALA W    14                                                      
REMARK 465     ALA W    15                                                      
REMARK 465     SER W    16                                                      
REMARK 465     MET X     0                                                      
REMARK 465     MET Y    -2                                                      
REMARK 465     ALA Y    -1                                                      
REMARK 465     MET Y     0                                                      
REMARK 465     MET Z     0                                                      
REMARK 465     ALA Z     1                                                      
REMARK 465     ALA Z     2                                                      
REMARK 465     SER Z     3                                                      
REMARK 465     LYS Z     4                                                      
REMARK 465     MET b     0                                                      
REMARK 465     MET c   -26                                                      
REMARK 465     ALA c   -25                                                      
REMARK 465     PRO c   -24                                                      
REMARK 465     SER c   -23                                                      
REMARK 465     VAL c   -22                                                      
REMARK 465     VAL c   -21                                                      
REMARK 465     LEU c   -20                                                      
REMARK 465     ARG c   -19                                                      
REMARK 465     SER c   -18                                                      
REMARK 465     PHE c   -17                                                      
REMARK 465     SER c   -16                                                      
REMARK 465     ARG c   -15                                                      
REMARK 465     LEU c   -14                                                      
REMARK 465     LEU c   -13                                                      
REMARK 465     ALA c   -12                                                      
REMARK 465     PRO c   -11                                                      
REMARK 465     ALA c   -10                                                      
REMARK 465     ARG c    -9                                                      
REMARK 465     LEU c    -8                                                      
REMARK 465     PRO c    -7                                                      
REMARK 465     SER c    -6                                                      
REMARK 465     CYS c    -5                                                      
REMARK 465     SER c    -4                                                      
REMARK 465     SER c    -3                                                      
REMARK 465     THR c    -2                                                      
REMARK 465     ARG c    -1                                                      
REMARK 465     SER c     0                                                      
REMARK 465     LYS c     1                                                      
REMARK 465     GLU c    49                                                      
REMARK 465     ARG d   120                                                      
REMARK 465     MET e     0                                                      
REMARK 465     PRO e   105                                                      
REMARK 465     MET f     0                                                      
REMARK 465     THR f     1                                                      
REMARK 465     LEU f     2                                                      
REMARK 465     PHE f     3                                                      
REMARK 465     TRP f    55                                                      
REMARK 465     LYS f    56                                                      
REMARK 465     MET g   -28                                                      
REMARK 465     ALA g   -27                                                      
REMARK 465     ALA g   -26                                                      
REMARK 465     ARG g   -25                                                      
REMARK 465     LEU g   -24                                                      
REMARK 465     LEU g   -23                                                      
REMARK 465     SER g   -22                                                      
REMARK 465     LEU g   -21                                                      
REMARK 465     TYR g   -20                                                      
REMARK 465     GLY g   -19                                                      
REMARK 465     ARG g   -18                                                      
REMARK 465     CYS g   -17                                                      
REMARK 465     LEU g   -16                                                      
REMARK 465     SER g   -15                                                      
REMARK 465     ALA g   -14                                                      
REMARK 465     ALA g   -13                                                      
REMARK 465     GLY g   -12                                                      
REMARK 465     ALA g   -11                                                      
REMARK 465     MET g   -10                                                      
REMARK 465     ARG g    -9                                                      
REMARK 465     GLY g    -8                                                      
REMARK 465     LEU g    -7                                                      
REMARK 465     PRO g    -6                                                      
REMARK 465     ALA g    -5                                                      
REMARK 465     ALA g    -4                                                      
REMARK 465     ARG g    -3                                                      
REMARK 465     VAL g    -2                                                      
REMARK 465     ARG g    -1                                                      
REMARK 465     TRP g     0                                                      
REMARK 465     GLU g     1                                                      
REMARK 465     SER g     2                                                      
REMARK 465     SER g     3                                                      
REMARK 465     ARG g     4                                                      
REMARK 465     ALA g     5                                                      
REMARK 465     VAL g     6                                                      
REMARK 465     ILE g     7                                                      
REMARK 465     ALA g     8                                                      
REMARK 465     PRO g     9                                                      
REMARK 465     SER g    10                                                      
REMARK 465     GLY g    11                                                      
REMARK 465     VAL g    12                                                      
REMARK 465     GLU g    13                                                      
REMARK 465     LYS g    14                                                      
REMARK 465     LYS g    15                                                      
REMARK 465     ARG g    16                                                      
REMARK 465     GLN g    17                                                      
REMARK 465     ARG g    18                                                      
REMARK 465     GLU g    19                                                      
REMARK 465     PRO g    20                                                      
REMARK 465     ASP g   122                                                      
REMARK 465     MET h   -45                                                      
REMARK 465     ALA h   -44                                                      
REMARK 465     ALA h   -43                                                      
REMARK 465     MET h   -42                                                      
REMARK 465     SER h   -41                                                      
REMARK 465     LEU h   -40                                                      
REMARK 465     LEU h   -39                                                      
REMARK 465     GLN h   -38                                                      
REMARK 465     ARG h   -37                                                      
REMARK 465     ALA h   -36                                                      
REMARK 465     SER h   -35                                                      
REMARK 465     VAL h   -34                                                      
REMARK 465     SER h   -33                                                      
REMARK 465     ALA h   -32                                                      
REMARK 465     LEU h   -31                                                      
REMARK 465     THR h   -30                                                      
REMARK 465     ALA h   -29                                                      
REMARK 465     LEU h   -28                                                      
REMARK 465     SER h   -27                                                      
REMARK 465     CYS h   -26                                                      
REMARK 465     ARG h   -25                                                      
REMARK 465     ARG h   -24                                                      
REMARK 465     ALA h   -23                                                      
REMARK 465     GLY h   -22                                                      
REMARK 465     PRO h   -21                                                      
REMARK 465     ARG h   -20                                                      
REMARK 465     LEU h   -19                                                      
REMARK 465     GLY h   -18                                                      
REMARK 465     VAL h   -17                                                      
REMARK 465     GLY h   -16                                                      
REMARK 465     SER h   -15                                                      
REMARK 465     PHE h   -14                                                      
REMARK 465     LEU h   -13                                                      
REMARK 465     THR h   -12                                                      
REMARK 465     ARG h   -11                                                      
REMARK 465     SER h   -10                                                      
REMARK 465     PHE h    -9                                                      
REMARK 465     PRO h    -8                                                      
REMARK 465     LYS h    -7                                                      
REMARK 465     THR h    -6                                                      
REMARK 465     VAL h    -5                                                      
REMARK 465     ALA h    -4                                                      
REMARK 465     PRO h    -3                                                      
REMARK 465     VAL h    -2                                                      
REMARK 465     ARG h    -1                                                      
REMARK 465     HIS h     0                                                      
REMARK 465     SER h     1                                                      
REMARK 465     GLY h     2                                                      
REMARK 465     ASP h     3                                                      
REMARK 465     HIS h     4                                                      
REMARK 465     GLY h     5                                                      
REMARK 465     ASN h   143                                                      
REMARK 465     MET i     0                                                      
REMARK 465     PRO i    36                                                      
REMARK 465     ARG i    37                                                      
REMARK 465     ARG i    38                                                      
REMARK 465     MET i    39                                                      
REMARK 465     TRP i    40                                                      
REMARK 465     PRO i    41                                                      
REMARK 465     LEU i    42                                                      
REMARK 465     GLU i    43                                                      
REMARK 465     ARG i    44                                                      
REMARK 465     PHE i    45                                                      
REMARK 465     TRP i    46                                                      
REMARK 465     ASP i    47                                                      
REMARK 465     ASN i    48                                                      
REMARK 465     PHE i    49                                                      
REMARK 465     LEU i    50                                                      
REMARK 465     ARG i    51                                                      
REMARK 465     ASP i    52                                                      
REMARK 465     GLY i    53                                                      
REMARK 465     ALA i    54                                                      
REMARK 465     VAL i    55                                                      
REMARK 465     TRP i    56                                                      
REMARK 465     LYS i    57                                                      
REMARK 465     ASN i    58                                                      
REMARK 465     MET i    59                                                      
REMARK 465     VAL i    60                                                      
REMARK 465     PHE i    61                                                      
REMARK 465     MET j   -32                                                      
REMARK 465     SER j   -31                                                      
REMARK 465     ALA j   -30                                                      
REMARK 465     LEU j   -29                                                      
REMARK 465     THR j   -28                                                      
REMARK 465     ARG j   -27                                                      
REMARK 465     LEU j   -26                                                      
REMARK 465     VAL j   -25                                                      
REMARK 465     PRO j   -24                                                      
REMARK 465     PHE j   -23                                                      
REMARK 465     GLY j   -22                                                      
REMARK 465     ARG j   -21                                                      
REMARK 465     VAL j   -20                                                      
REMARK 465     GLY j   -19                                                      
REMARK 465     GLY j   -18                                                      
REMARK 465     ARG j   -17                                                      
REMARK 465     LEU j   -16                                                      
REMARK 465     LEU j   -15                                                      
REMARK 465     ARG j   -14                                                      
REMARK 465     GLY j   -13                                                      
REMARK 465     CYS j   -12                                                      
REMARK 465     ARG j   -11                                                      
REMARK 465     ALA j   -10                                                      
REMARK 465     ARG j    -9                                                      
REMARK 465     ALA j    -8                                                      
REMARK 465     ALA j    -7                                                      
REMARK 465     GLY j    -6                                                      
REMARK 465     ASP j    -5                                                      
REMARK 465     SER j    -4                                                      
REMARK 465     GLY j    -3                                                      
REMARK 465     VAL j    -2                                                      
REMARK 465     ARG j    -1                                                      
REMARK 465     HIS j     0                                                      
REMARK 465     ALA j     1                                                      
REMARK 465     GLY j     2                                                      
REMARK 465     GLY j     3                                                      
REMARK 465     GLY j     4                                                      
REMARK 465     VAL j     5                                                      
REMARK 465     ILE j    66                                                      
REMARK 465     PRO j    67                                                      
REMARK 465     PRO j    68                                                      
REMARK 465     ASP j    69                                                      
REMARK 465     ASP j    70                                                      
REMARK 465     GLU j    71                                                      
REMARK 465     ASP j    72                                                      
REMARK 465     MET k     0                                                      
REMARK 465     ALA k     1                                                      
REMARK 465     ALA k     2                                                      
REMARK 465     GLY k     3                                                      
REMARK 465     HIS k     4                                                      
REMARK 465     GLY k     5                                                      
REMARK 465     HIS k     6                                                      
REMARK 465     GLU k     7                                                      
REMARK 465     HIS k     8                                                      
REMARK 465     GLY k     9                                                      
REMARK 465     HIS k    10                                                      
REMARK 465     GLU k    11                                                      
REMARK 465     HIS k    12                                                      
REMARK 465     GLY k    13                                                      
REMARK 465     HIS k    14                                                      
REMARK 465     GLY k    15                                                      
REMARK 465     HIS k    16                                                      
REMARK 465     GLY k    17                                                      
REMARK 465     LYS k    18                                                      
REMARK 465     MET k    19                                                      
REMARK 465     PHE k    92                                                      
REMARK 465     LEU k    93                                                      
REMARK 465     ASP k    94                                                      
REMARK 465     SER k    95                                                      
REMARK 465     GLN k    96                                                      
REMARK 465     ASN k    97                                                      
REMARK 465     GLY k    98                                                      
REMARK 465     ASP k    99                                                      
REMARK 465     LYS k   100                                                      
REMARK 465     LYS k   101                                                      
REMARK 465     HIS k   102                                                      
REMARK 465     HIS k   103                                                      
REMARK 465     MET l   -28                                                      
REMARK 465     ALA l   -27                                                      
REMARK 465     ALA l   -26                                                      
REMARK 465     ALA l   -25                                                      
REMARK 465     ARG l   -24                                                      
REMARK 465     ALA l   -23                                                      
REMARK 465     ALA l   -22                                                      
REMARK 465     ALA l   -21                                                      
REMARK 465     LEU l   -20                                                      
REMARK 465     GLY l   -19                                                      
REMARK 465     VAL l   -18                                                      
REMARK 465     ARG l   -17                                                      
REMARK 465     TRP l   -16                                                      
REMARK 465     LEU l   -15                                                      
REMARK 465     GLN l   -14                                                      
REMARK 465     ARG l   -13                                                      
REMARK 465     THR l   -12                                                      
REMARK 465     THR l   -11                                                      
REMARK 465     ARG l   -10                                                      
REMARK 465     GLY l    -9                                                      
REMARK 465     VAL l    -8                                                      
REMARK 465     VAL l    -7                                                      
REMARK 465     PRO l    -6                                                      
REMARK 465     LEU l    -5                                                      
REMARK 465     GLU l    -4                                                      
REMARK 465     ALA l    -3                                                      
REMARK 465     ARG l    -2                                                      
REMARK 465     ARG l    -1                                                      
REMARK 465     ALA l     0                                                      
REMARK 465     PHE l     1                                                      
REMARK 465     HIS l     2                                                      
REMARK 465     TYR l   155                                                      
REMARK 465     ASP l   156                                                      
REMARK 465     ILE l   157                                                      
REMARK 465     MET m     0                                                      
REMARK 465     SER m     1                                                      
REMARK 465     GLY m     2                                                      
REMARK 465     SER m     3                                                      
REMARK 465     LYS m     4                                                      
REMARK 465     MET n     0                                                      
REMARK 465     PRO n   177                                                      
REMARK 465     THR n   178                                                      
REMARK 465     MET o     0                                                      
REMARK 465     GLY o     1                                                      
REMARK 465     ALA o     2                                                      
REMARK 465     HIS o     3                                                      
REMARK 465     LEU o     4                                                      
REMARK 465     THR o     5                                                      
REMARK 465     ARG o     6                                                      
REMARK 465     ARG o     7                                                      
REMARK 465     TYR o     8                                                      
REMARK 465     LEU o     9                                                      
REMARK 465     TRP o    10                                                      
REMARK 465     ASP o    11                                                      
REMARK 465     LYS o   117                                                      
REMARK 465     GLU o   118                                                      
REMARK 465     ALA o   119                                                      
REMARK 465     ARG o   120                                                      
REMARK 465     VAL o   121                                                      
REMARK 465     ALA o   122                                                      
REMARK 465     GLN o   123                                                      
REMARK 465     GLY o   124                                                      
REMARK 465     GLN o   125                                                      
REMARK 465     GLY o   126                                                      
REMARK 465     GLU o   127                                                      
REMARK 465     GLY o   128                                                      
REMARK 465     GLU o   129                                                      
REMARK 465     VAL o   130                                                      
REMARK 465     GLY o   131                                                      
REMARK 465     PRO o   132                                                      
REMARK 465     GLU o   133                                                      
REMARK 465     VAL o   134                                                      
REMARK 465     ALA o   135                                                      
REMARK 465     LEU o   136                                                      
REMARK 465     MET p     0                                                      
REMARK 465     PRO p     1                                                      
REMARK 465     GLU p   172                                                      
REMARK 465     ALA p   173                                                      
REMARK 465     ALA p   174                                                      
REMARK 465     ALA p   175                                                      
REMARK 465     LYS q   145                                                      
REMARK 465     MET r     0                                                      
REMARK 465     SER r    77                                                      
REMARK 465     GLY r    78                                                      
REMARK 465     LYS r    79                                                      
REMARK 465     ALA r    80                                                      
REMARK 465     ALA r    81                                                      
REMARK 465     GLU r    82                                                      
REMARK 465     SER r    83                                                      
REMARK 465     SER r    84                                                      
REMARK 465     ALA r    85                                                      
REMARK 465     MET r    86                                                      
REMARK 465     ALA r    87                                                      
REMARK 465     ALA r    88                                                      
REMARK 465     THR r    89                                                      
REMARK 465     MET s   -34                                                      
REMARK 465     ALA s   -33                                                      
REMARK 465     VAL s   -32                                                      
REMARK 465     SER s   -31                                                      
REMARK 465     LEU s   -30                                                      
REMARK 465     LEU s   -29                                                      
REMARK 465     LEU s   -28                                                      
REMARK 465     ARG s   -27                                                      
REMARK 465     GLY s   -26                                                      
REMARK 465     GLY s   -25                                                      
REMARK 465     ARG s   -24                                                      
REMARK 465     ILE s   -23                                                      
REMARK 465     ARG s   -22                                                      
REMARK 465     ALA s   -21                                                      
REMARK 465     LEU s   -20                                                      
REMARK 465     LYS s   -19                                                      
REMARK 465     ALA s   -18                                                      
REMARK 465     VAL s   -17                                                      
REMARK 465     LEU s   -16                                                      
REMARK 465     LEU s   -15                                                      
REMARK 465     GLU s   -14                                                      
REMARK 465     ALA s   -13                                                      
REMARK 465     ARG s   -12                                                      
REMARK 465     VAL s   -11                                                      
REMARK 465     PHE s   -10                                                      
REMARK 465     PRO s    -9                                                      
REMARK 465     GLY s    -8                                                      
REMARK 465     GLU s    -7                                                      
REMARK 465     LEU s    -6                                                      
REMARK 465     VAL s    -5                                                      
REMARK 465     SER s    -4                                                      
REMARK 465     VAL s    -3                                                      
REMARK 465     VAL s    -2                                                      
REMARK 465     ARG s    -1                                                      
REMARK 465     LEU s     0                                                      
REMARK 465     SER s     1                                                      
REMARK 465     THR s     2                                                      
REMARK 465     GLU s     3                                                      
REMARK 465     SER s     4                                                      
REMARK 465     GLU s     5                                                      
REMARK 465     LYS s     6                                                      
REMARK 465     SER s     7                                                      
REMARK 465     ALA s     8                                                      
REMARK 465     LYS s     9                                                      
REMARK 465     GLU s    10                                                      
REMARK 465     LYS s    11                                                      
REMARK 465     GLU s    12                                                      
REMARK 465     LEU s    13                                                      
REMARK 465     HIS s    14                                                      
REMARK 465     PRO s    15                                                      
REMARK 465     LYS s    16                                                      
REMARK 465     THR s    17                                                      
REMARK 465     GLN s    18                                                      
REMARK 465     SER s    19                                                      
REMARK 465     VAL s    20                                                      
REMARK 465     LEU s    21                                                      
REMARK 465     LYS s    22                                                      
REMARK 465     GLU s    23                                                      
REMARK 465     PRO s    24                                                      
REMARK 465     GLU s    25                                                      
REMARK 465     PRO s    26                                                      
REMARK 465     THR s    27                                                      
REMARK 465     ASP s    28                                                      
REMARK 465     HIS s    69                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS D  40    CG   CD   CE   NZ                                   
REMARK 470     GLU D  41    CG   CD   OE1  OE2                                  
REMARK 470     LYS D  42    CG   CD   CE   NZ                                   
REMARK 470     LYS I   8    CG   CD   CE   NZ                                   
REMARK 470     GLU I   9    CG   CD   OE1  OE2                                  
REMARK 470     GLN I  10    CG   CD   OE1  NE2                                  
REMARK 470     GLU I  11    CG   CD   OE1  OE2                                  
REMARK 470     SER I  12    OG                                                  
REMARK 470     GLU I  13    CG   CD   OE1  OE2                                  
REMARK 470     VAL I  14    CG1  CG2                                            
REMARK 470     LYS i  62    CG   CD   CE   NZ                                   
REMARK 470     TYR i  64    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ARG i  65    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP i 124    CG   OD1  OD2                                       
REMARK 470     GLN i 125    CG   CD   OE1  NE2                                  
REMARK 470     HIS i 126    CG   ND1  CD2  CE1  NE2                             
REMARK 470     HIS i 127    CG   ND1  CD2  CE1  NE2                             
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OH   TYR l    46     O    ILE l    76              2.02            
REMARK 500   OG   SER L   371     OG   SER j    29              2.02            
REMARK 500   OG1  THR P    27     O3B  NDP P   501              2.03            
REMARK 500   O    PHE H   104     OG1  THR H   108              2.04            
REMARK 500   O    ALA L   220     OG   SER L   224              2.04            
REMARK 500   OH   TYR i    94     O    LYS p     6              2.05            
REMARK 500   OG1  THR d   108     O    CYS p    76              2.05            
REMARK 500   O    SER L    86     OG1  THR L    90              2.05            
REMARK 500   OG1  THR D   246     O    VAL V    11              2.06            
REMARK 500   OG   SER D   341     OG   SER D   344              2.06            
REMARK 500   OG   SER Y    47     OE1  GLU Y    50              2.06            
REMARK 500   OE1  GLU D   224     OH   TYR I    42              2.07            
REMARK 500   O    ILE G   477     OG1  THR G   481              2.07            
REMARK 500   O    GLU J   111     OH   TYR e    69              2.07            
REMARK 500   O    ALA H    18     OG1  THR H    21              2.07            
REMARK 500   OD1  ASN s    41     OG1  THR s    44              2.07            
REMARK 500   OH   TYR O   108     O    LEU O   164              2.07            
REMARK 500   O    LEU M   179     OG1  THR M   183              2.08            
REMARK 500   OE2  GLU G   637     OG   SER S    58              2.08            
REMARK 500   O    LEU L   246     OG1  THR L   251              2.08            
REMARK 500   OG   SER M    19     OE2  GLU f     8              2.08            
REMARK 500   O    ALA L   303     OG1  THR L   306              2.09            
REMARK 500   OH   TYR L   120     OB3  CDL L   702              2.09            
REMARK 500   OG   SER C    43     O    LEU C    45              2.10            
REMARK 500   O    ASP O   252     OG1  THR O   255              2.10            
REMARK 500   O    LYS i    62     OG   SER i    66              2.10            
REMARK 500   OG   SER r     2     O1   CDL H   405              2.10            
REMARK 500   O    PHE A    56     OH   TYR J    69              2.10            
REMARK 500   OG1  THR V    47     OE2  GLU V    86              2.11            
REMARK 500   O    SER L   520     OG1  THR L   524              2.11            
REMARK 500   O    GLU R    34     OH   TYR q   127              2.11            
REMARK 500   O    TYR c    30     OG1  THR c    34              2.11            
REMARK 500   O    MET L   313     OG1  THR L   316              2.12            
REMARK 500   O    ILE M   424     OH   TYR n   105              2.13            
REMARK 500   O    CYS o    68     OG   SER o    72              2.13            
REMARK 500   O    ASP L   163     OG1  THR L   166              2.13            
REMARK 500   O    LEU L   293     NH1  ARG L   425              2.14            
REMARK 500   O    LEU F    65     OG1  THR F    75              2.14            
REMARK 500   OG1  THR M    40     OH   TYR h    80              2.14            
REMARK 500   O    ASN D    50     OH   TYR H   127              2.14            
REMARK 500   O    ALA Q   120     OG1  THR Q   128              2.14            
REMARK 500   O    LEU N   128     OG1  THR N   132              2.15            
REMARK 500   OG1  THR R    12     O    THR R    14              2.15            
REMARK 500   O    ASP C    82     OH   TYR D   387              2.15            
REMARK 500   O    GLY d    38     OG1  THR d    41              2.15            
REMARK 500   NH2  ARG X   165     OD1  ASP d    87              2.15            
REMARK 500   O    SER r    45     ND2  ASN r    51              2.16            
REMARK 500   O    MET H   225     OG1  THR H   229              2.16            
REMARK 500   OH   TYR l    33     O    ASP l    45              2.16            
REMARK 500   OG   SER L   195     OE1  GLN L   200              2.16            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      82 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A  24   CA  -  CB  -  CG  ANGL. DEV. =  18.1 DEGREES          
REMARK 500    CYS B  65   CA  -  CB  -  SG  ANGL. DEV. =   7.2 DEGREES          
REMARK 500    LEU V 102   CB  -  CG  -  CD2 ANGL. DEV. =  11.7 DEGREES          
REMARK 500    PRO f  49   C   -  N   -  CD  ANGL. DEV. = -13.7 DEGREES          
REMARK 500    ASP m  18   CB  -  CG  -  OD1 ANGL. DEV. =   6.3 DEGREES          
REMARK 500    ASP r 108   CB  -  CG  -  OD1 ANGL. DEV. =   5.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    GLN A  26       70.64     60.29                                   
REMARK 500    ASN A  28       40.73   -141.49                                   
REMARK 500    SER A  31      -43.95   -150.16                                   
REMARK 500    TYR A  37      -74.29    -87.52                                   
REMARK 500    GLU A  38       47.85     31.94                                   
REMARK 500    ALA A  47       -5.59     72.49                                   
REMARK 500    TRP A 113       72.46     60.73                                   
REMARK 500    THR A 114      128.27    -37.97                                   
REMARK 500    LEU B  62      -13.19     84.23                                   
REMARK 500    ALA B  63     -171.22   -171.17                                   
REMARK 500    ASP B 115       47.69    -91.42                                   
REMARK 500    ILE B 149      -58.70   -124.42                                   
REMARK 500    ARG C  12       81.13     59.12                                   
REMARK 500    LEU C  33       60.35   -154.68                                   
REMARK 500    ALA C  70       47.18   -140.15                                   
REMARK 500    PRO C  84       43.19    -84.50                                   
REMARK 500    THR C 115       78.38   -162.55                                   
REMARK 500    ASP C 147       62.83     39.61                                   
REMARK 500    ILE C 151      -56.56   -121.07                                   
REMARK 500    GLU C 193       79.76     60.58                                   
REMARK 500    PHE C 194      121.27    -35.52                                   
REMARK 500    ASP C 198       57.96    -94.54                                   
REMARK 500    PRO C 202     -159.83    -73.13                                   
REMARK 500    TRP C 203       83.43     67.76                                   
REMARK 500    GLU C 204      -43.86    -29.62                                   
REMARK 500    ALA C 205      -11.38     76.53                                   
REMARK 500    PHE C 206       75.35   -151.49                                   
REMARK 500    ALA D  17       -8.16     75.56                                   
REMARK 500    MET D  19      -13.83     72.55                                   
REMARK 500    TYR D  20       75.17   -151.39                                   
REMARK 500    LEU D  39       45.19   -140.36                                   
REMARK 500    THR D  45      -12.92     72.05                                   
REMARK 500    ASN D  46       26.25     48.48                                   
REMARK 500    MET D  47       70.61     52.34                                   
REMARK 500    PRO D  53       42.30    -83.94                                   
REMARK 500    VAL D 184      -61.28   -124.66                                   
REMARK 500    SER D 256      -11.93     73.32                                   
REMARK 500    VAL D 277       94.91    -69.32                                   
REMARK 500    GLN D 280       55.66    -94.07                                   
REMARK 500    ASP D 292       43.42   -141.35                                   
REMARK 500    CYS D 293       -2.50     67.43                                   
REMARK 500    ASP D 326       51.63    -92.03                                   
REMARK 500    TYR D 356       14.04   -143.33                                   
REMARK 500    GLN D 357       71.06     57.31                                   
REMARK 500    ALA D 362      146.64   -171.34                                   
REMARK 500    ARG D 388       77.40     61.76                                   
REMARK 500    SER D 406       53.41    -92.13                                   
REMARK 500    MET D 410     -169.93   -103.66                                   
REMARK 500    THR D 420       48.97    -93.05                                   
REMARK 500    ASP E  11       57.71     32.91                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     546 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 GLU B  119     PRO B  120                  136.74                    
REMARK 500 GLY B  134     TYR B  135                  146.33                    
REMARK 500 ARG C    8     PRO C    9                 -148.18                    
REMARK 500 THR D   87     GLU D   88                  149.33                    
REMARK 500 PHE D  171     GLU D  172                  149.85                    
REMARK 500 ASN E  150     ALA E  151                 -142.83                    
REMARK 500 LYS F  206     PRO F  207                  145.14                    
REMARK 500 LYS G   61     ALA G   62                  149.01                    
REMARK 500 ILE G  258     ASN G  259                 -132.23                    
REMARK 500 ASN G  259     GLU G  260                  132.62                    
REMARK 500 ALA G  484     ALA G  485                 -143.55                    
REMARK 500 ALA G  485     GLU G  486                  145.87                    
REMARK 500 PRO H   90     MET H   91                  142.18                    
REMARK 500 MET H   91     PRO H   92                 -134.29                    
REMARK 500 MET H  156     ASN H  157                  145.00                    
REMARK 500 LEU H  207     VAL H  208                 -146.94                    
REMARK 500 ILE H  249     ASN H  250                  143.27                    
REMARK 500 ASP J  129     ASP J  130                 -144.38                    
REMARK 500 MET L  108     HIS L  109                  147.84                    
REMARK 500 TYR L  159     GLY L  160                  146.00                    
REMARK 500 GLU L  197     LEU L  198                 -146.53                    
REMARK 500 MET L  383     PRO L  384                 -148.24                    
REMARK 500 LYS L  434     PRO L  435                 -147.71                    
REMARK 500 SER L  520     SER L  521                  149.14                    
REMARK 500 LEU M  369     PRO M  370                 -144.36                    
REMARK 500 ALA N  109     PRO N  110                  149.97                    
REMARK 500 ILE N  141     LEU N  142                 -149.61                    
REMARK 500 ARG P   97     GLU P   98                  143.60                    
REMARK 500 ILE P  331     GLU P  332                  148.99                    
REMARK 500 THR P  334     LYS P  335                  133.52                    
REMARK 500 LEU Q   69     MET Q   70                 -147.87                    
REMARK 500 ILE U   65     ASP U   66                  148.01                    
REMARK 500 THR W   57     VAL W   58                  141.51                    
REMARK 500 ARG X  146     PRO X  147                 -146.94                    
REMARK 500 LEU Z   29     SER Z   30                 -145.48                    
REMARK 500 SER a   55     GLY a   56                  149.23                    
REMARK 500 TYR a   61     VAL a   62                 -132.36                    
REMARK 500 ASP d   16     GLU d   17                  134.36                    
REMARK 500 LYS d  104     GLU d  105                 -140.76                    
REMARK 500 ILE e   46     GLY e   47                 -145.02                    
REMARK 500 ARG f   48     PRO f   49                  140.58                    
REMARK 500 VAL g   35     TYR g   36                  138.21                    
REMARK 500 MET g  106     GLU g  107                 -143.99                    
REMARK 500 GLU i   31     PRO i   32                 -134.93                    
REMARK 500 GLU i  114     VAL i  115                 -130.10                    
REMARK 500 ARG i  120     ASP i  121                 -145.52                    
REMARK 500 ARG j   12     GLU j   13                 -148.65                    
REMARK 500 THR j   18     ARG j   19                 -149.30                    
REMARK 500 TRP l   60     TYR l   61                 -139.96                    
REMARK 500 ASN l  135     ASN l  136                  149.55                    
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      58 NON CIS, NON-TRANS OMEGA OUTLIERS.            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    THR J 170         12.68                                           
REMARK 500    ILE L 598        -12.74                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 610                                                                      
REMARK 610 MISSING HETEROATOM                                                   
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 610 I=INSERTION CODE):                                                   
REMARK 610   M RES C SSEQI                                                      
REMARK 610     3PE A  201                                                       
REMARK 610     PC1 H  402                                                       
REMARK 610     PC1 H  404                                                       
REMARK 610     CDL H  405                                                       
REMARK 610     PC1 H  406                                                       
REMARK 610     CDL L  702                                                       
REMARK 610     CDL L  703                                                       
REMARK 610     3PE L  704                                                       
REMARK 610     3PE M  502                                                       
REMARK 610     3PE M  506                                                       
REMARK 610     CDL M  507                                                       
REMARK 610     PC1 P  401                                                       
REMARK 610     EHZ T  201                                                       
REMARK 610     EHZ U  201                                                       
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 B 201  FE3                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B  64   SG                                                     
REMARK 620 2 SF4 B 201   S1  107.4                                              
REMARK 620 3 SF4 B 201   S2  119.8 104.1                                        
REMARK 620 4 SF4 B 201   S4  115.3 104.3 104.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 B 201  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B  65   SG                                                     
REMARK 620 2 SF4 B 201   S1  110.9                                              
REMARK 620 3 SF4 B 201   S3  116.7 104.1                                        
REMARK 620 4 SF4 B 201   S4  115.8 104.2 103.7                                  
REMARK 620 5 CYS B 159   O    72.2  71.2  71.7 171.9                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 B 201  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B 129   SG                                                     
REMARK 620 2 SF4 B 201   S2  117.1                                              
REMARK 620 3 SF4 B 201   S3  103.2 104.8                                        
REMARK 620 4 SF4 B 201   S4  121.0 104.5 104.4                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 B 201  FE4                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B 159   SG                                                     
REMARK 620 2 SF4 B 201   S1  115.9                                              
REMARK 620 3 SF4 B 201   S2  110.8 104.3                                        
REMARK 620 4 SF4 B 201   S3  115.5 104.8 104.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES E 301  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS E 103   SG                                                     
REMARK 620 2 FES E 301   S1  115.9                                              
REMARK 620 3 FES E 301   S2  104.4 105.9                                        
REMARK 620 4 CYS E 108   SG  106.5 112.6 111.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES E 301  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS E 144   SG                                                     
REMARK 620 2 FES E 301   S1  116.2                                              
REMARK 620 3 FES E 301   S2  114.9 106.1                                        
REMARK 620 4 CYS E 148   SG   97.4 112.9 109.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 F 502  FE4                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS F 359   SG                                                     
REMARK 620 2 SF4 F 502   S1  125.3                                              
REMARK 620 3 SF4 F 502   S2  113.8 104.4                                        
REMARK 620 4 SF4 F 502   S3  102.5 104.4 104.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 F 502  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS F 362   SG                                                     
REMARK 620 2 SF4 F 502   S2  114.1                                              
REMARK 620 3 SF4 F 502   S3  112.0 104.6                                        
REMARK 620 4 SF4 F 502   S4  116.2 104.4 104.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 F 502  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS F 365   SG                                                     
REMARK 620 2 SF4 F 502   S1  129.6                                              
REMARK 620 3 SF4 F 502   S3  109.0 104.5                                        
REMARK 620 4 SF4 F 502   S4  102.4 104.6 104.4                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 F 502  FE3                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS F 405   SG                                                     
REMARK 620 2 SF4 F 502   S1  114.0                                              
REMARK 620 3 SF4 F 502   S2  122.9 104.5                                        
REMARK 620 4 SF4 F 502   S4  104.9 104.4 104.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES G 803  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS G  41   SG                                                     
REMARK 620 2 FES G 803   S1  102.1                                              
REMARK 620 3 FES G 803   S2   96.6 104.5                                        
REMARK 620 4 CYS G  52   SG  140.8 113.8  89.5                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES G 803  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS G  55   SG                                                     
REMARK 620 2 FES G 803   S1  112.8                                              
REMARK 620 3 FES G 803   S2  116.2 104.8                                        
REMARK 620 4 CYS G  69   SG   97.4 133.1  91.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 G 801  FE3                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS G 101   NE2                                                    
REMARK 620 2 SF4 G 801   S1  111.4                                              
REMARK 620 3 SF4 G 801   S2  119.6 104.2                                        
REMARK 620 4 SF4 G 801   S4  111.6 104.6 104.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 G 801  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS G 105   SG                                                     
REMARK 620 2 SF4 G 801   S1  108.4                                              
REMARK 620 3 SF4 G 801   S3  121.8 104.3                                        
REMARK 620 4 SF4 G 801   S4  112.2 104.4 104.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 G 801  FE4                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS G 108   SG                                                     
REMARK 620 2 SF4 G 801   S1  116.9                                              
REMARK 620 3 SF4 G 801   S2  119.2 104.5                                        
REMARK 620 4 SF4 G 801   S3  105.6 104.4 104.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 G 801  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS G 114   SG                                                     
REMARK 620 2 SF4 G 801   S2  104.4                                              
REMARK 620 3 SF4 G 801   S3  115.1 104.5                                        
REMARK 620 4 SF4 G 801   S4  122.4 104.4 104.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 G 802  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS G 153   SG                                                     
REMARK 620 2 SF4 G 802   S1  114.3                                              
REMARK 620 3 SF4 G 802   S3  119.8 104.4                                        
REMARK 620 4 SF4 G 802   S4  108.3 104.5 104.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 G 802  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS G 156   SG                                                     
REMARK 620 2 SF4 G 802   S2   98.8                                              
REMARK 620 3 SF4 G 802   S3  118.6 104.4                                        
REMARK 620 4 SF4 G 802   S4  123.5 104.3 104.4                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 G 802  FE3                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS G 159   SG                                                     
REMARK 620 2 SF4 G 802   S1  115.5                                              
REMARK 620 3 SF4 G 802   S2  113.9 104.2                                        
REMARK 620 4 SF4 G 802   S4  113.1 104.6 104.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 G 802  FE4                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS G 203   SG                                                     
REMARK 620 2 SF4 G 802   S1  118.8                                              
REMARK 620 3 SF4 G 802   S2  114.9 104.3                                        
REMARK 620 4 SF4 G 802   S3  108.5 104.4 104.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 I 202  FE3                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS I  79   SG                                                     
REMARK 620 2 SF4 I 202   S1  102.0                                              
REMARK 620 3 SF4 I 202   S2  122.1 104.3                                        
REMARK 620 4 SF4 I 202   S4  117.5 104.4 104.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 I 202  FE4                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS I  82   SG                                                     
REMARK 620 2 SF4 I 202   S1  118.3                                              
REMARK 620 3 SF4 I 202   S2  106.4 104.6                                        
REMARK 620 4 SF4 I 202   S3  117.5 103.9 104.8                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 I 202  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS I  85   SG                                                     
REMARK 620 2 SF4 I 202   S1  113.7                                              
REMARK 620 3 SF4 I 202   S3  113.6 104.2                                        
REMARK 620 4 SF4 I 202   S4  115.2 104.5 104.5                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 I 201  FE4                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS I  89   SG                                                     
REMARK 620 2 SF4 I 201   S1  112.7                                              
REMARK 620 3 SF4 I 201   S2  118.2 104.2                                        
REMARK 620 4 SF4 I 201   S3  111.5 104.7 104.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 I 201  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS I 118   SG                                                     
REMARK 620 2 SF4 I 201   S1   98.5                                              
REMARK 620 3 SF4 I 201   S3  124.3 104.5                                        
REMARK 620 4 SF4 I 201   S4  118.4 104.4 103.9                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 I 201  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS I 121   SG                                                     
REMARK 620 2 SF4 I 201   S2  102.0                                              
REMARK 620 3 SF4 I 201   S3  116.7 104.4                                        
REMARK 620 4 SF4 I 201   S4  122.6 104.5 104.5                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 I 201  FE3                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS I 124   SG                                                     
REMARK 620 2 SF4 I 201   S1  120.2                                              
REMARK 620 3 SF4 I 201   S2  109.3 104.2                                        
REMARK 620 4 SF4 I 201   S4  112.9 104.4 104.5                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             SF4 I 202  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS I 128   SG                                                     
REMARK 620 2 SF4 I 202   S2  106.5                                              
REMARK 620 3 SF4 I 202   S3  112.7 104.4                                        
REMARK 620 4 SF4 I 202   S4  123.0 104.3 104.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN R 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS R  59   SG                                                     
REMARK 620 2 HIS R  68   NE2 106.0                                              
REMARK 620 3 CYS R  84   SG   96.6 102.7                                        
REMARK 620 4 CYS R  87   SG  111.6 132.4 101.0                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE A 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SF4 B 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue FES E 301                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue FMN F 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SF4 F 502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SF4 G 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SF4 G 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue FES G 803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE H 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue PC1 H 402                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE H 403                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue PC1 H 404                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CDL H 405                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue PC1 H 406                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SF4 I 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SF4 I 202                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE L 701                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CDL L 702                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CDL L 703                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE L 704                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE M 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE M 502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE M 503                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE M 504                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE M 505                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE M 506                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CDL M 507                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AF1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 3PE N 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AF2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP O 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AF3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue PC1 P 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AF4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NDP P 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AF5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN R 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AF6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue EHZ T 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AF7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue EHZ U 201                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-4345   RELATED DB: EMDB                              
REMARK 900 MOUSE MITOCHONDRIAL COMPLEX I IN THE ACTIVE STATE                    
DBREF  6G2J A    1   115  UNP    P03899   NU3M_MOUSE       1    115             
DBREF  6G2J B  -34   189  UNP    Q9DC70   NDUS7_MOUSE      1    224             
DBREF  6G2J C  -34   228  UNP    Q9DCT2   NDUS3_MOUSE      1    263             
DBREF  6G2J D  -32   430  UNP    Q91WD5   NDUS2_MOUSE      1    463             
DBREF  6G2J E  -30   217  UNP    Q9D6J6   NDUV2_MOUSE      1    248             
DBREF  6G2J F   10   437  UNP    Q91YT0   NDUV1_MOUSE     30    457             
DBREF  6G2J G  -22   704  UNP    Q91VD9   NDUS1_MOUSE      1    727             
DBREF  6G2J H    1   318  UNP    P03888   NU1M_MOUSE       1    318             
DBREF  6G2J I  -33   178  UNP    Q8K3J1   NDUS8_MOUSE      1    212             
DBREF  6G2J J    1   172  UNP    P03925   NU6M_MOUSE       1    172             
DBREF  6G2J K    1    98  UNP    P03903   NU4LM_MOUSE      1     98             
DBREF  6G2J L    1   607  UNP    P03921   NU5M_MOUSE       1    607             
DBREF  6G2J M    1   459  UNP    P03911   NU4M_MOUSE       1    459             
DBREF  6G2J N    1   345  UNP    P03893   NU2M_MOUSE       1    345             
DBREF  6G2J O  -34   320  UNP    Q99LC3   NDUAA_MOUSE      1    355             
DBREF  6G2J P  -34   342  UNP    Q9DC69   NDUA9_MOUSE      1    377             
DBREF  6G2J Q  -41   133  UNP    Q9CXZ1   NDUS4_MOUSE      1    175             
DBREF  6G2J R  -19    96  UNP    P52503   NDUS6_MOUSE      1    116             
DBREF  6G2J S    0    98  UNP    Q9CQ75   NDUA2_MOUSE      1     99             
DBREF  6G2J T  -67    88  UNP    Q9CR21   ACPM_MOUSE       1    156             
DBREF  6G2J U  -67    88  UNP    Q9CR21   ACPM_MOUSE       1    156             
DBREF  6G2J V    0   115  UNP    Q9CPP6   NDUA5_MOUSE      1    116             
DBREF  6G2J W    0   130  UNP    Q9CQZ5   NDUA6_MOUSE      1    131             
DBREF  6G2J X    0   171  UNP    Q9DCJ5   NDUA8_MOUSE      1    172             
DBREF  6G2J Y   -2   140  UNP    G5E814   G5E814_MOUSE     1    143             
DBREF  6G2J Z    0   143  UNP    Q9ERS2   NDUAD_MOUSE      1    144             
DBREF  6G2J a    1    67  UNP    O35683   NDUA1_MOUSE      1     67             
DBREF  6G2J b    0    83  UNP    Q9CQ91   NDUA3_MOUSE      1     84             
DBREF  6G2J c  -26    49  UNP    Q9CQY9   NDUC1_MOUSE      1     76             
DBREF  6G2J d    1   120  UNP    Q9CQ54   NDUC2_MOUSE      1    120             
DBREF  6G2J e    0   105  UNP    Q99LY9   NDUS5_MOUSE      1    106             
DBREF  6G2J f    0    56  UNP    P0DN34   NDUB1_MOUSE      1     57             
DBREF  6G2J g  -28   122  UNP    O09111   NDUBB_MOUSE      1    151             
DBREF  6G2J h  -45   143  UNP    Q9CQH3   NDUB5_MOUSE      1    189             
DBREF  6G2J i    0   127  UNP    Q3UIU2   NDUB6_MOUSE      1    128             
DBREF  6G2J j  -32    72  UNP    Q9CPU2   NDUB2_MOUSE      1    105             
DBREF  6G2J k    0   103  UNP    Q9CQZ6   NDUB3_MOUSE      1    104             
DBREF  6G2J l  -28   157  UNP    Q9D6J5   NDUB8_MOUSE      1    186             
DBREF  6G2J m    0   128  UNP    Q9CQC7   NDUB4_MOUSE      1    129             
DBREF  6G2J n    0   178  UNP    Q9CQJ8   NDUB9_MOUSE      1    179             
DBREF  6G2J o    0   136  UNP    Q9CR61   NDUB7_MOUSE      1    137             
DBREF  6G2J p    0   175  UNP    Q9DCS9   NDUBA_MOUSE      1    176             
DBREF  6G2J q    1   145  UNP    Q7TMF3   NDUAC_MOUSE      1    145             
DBREF  6G2J r    0   112  UNP    Q9Z1P6   NDUA7_MOUSE      1    113             
DBREF  6G2J s  -34    69  UNP    Q8BK30   NDUV3_MOUSE      1    104             
SEQADV 6G2J AME q    1  UNP  Q7TMF3    MET     1 CONFLICT                       
SEQRES   1 A  115  FME ASN LEU TYR THR VAL ILE PHE ILE ASN ILE LEU LEU          
SEQRES   2 A  115  SER LEU THR LEU ILE LEU VAL ALA PHE TRP LEU PRO GLN          
SEQRES   3 A  115  MET ASN LEU TYR SER GLU LYS ALA ASN PRO TYR GLU CYS          
SEQRES   4 A  115  GLY PHE ASP PRO THR SER SER ALA ARG LEU PRO PHE SER          
SEQRES   5 A  115  MET LYS PHE PHE LEU VAL ALA ILE THR PHE LEU LEU PHE          
SEQRES   6 A  115  ASP LEU GLU ILE ALA LEU LEU LEU PRO LEU PRO TRP ALA          
SEQRES   7 A  115  ILE GLN THR ILE LYS THR SER THR MET MET ILE MET ALA          
SEQRES   8 A  115  PHE ILE LEU VAL THR ILE LEU SER LEU GLY LEU ALA TYR          
SEQRES   9 A  115  GLU TRP THR GLN LYS GLY LEU GLU TRP THR GLU                  
SEQRES   1 B  224  MET ALA ALA LEU ALA ALA PRO GLY LEU LEU SER VAL ARG          
SEQRES   2 B  224  ILE LEU GLY LEU ARG THR ALA GLN VAL GLN LEU ARG ARG          
SEQRES   3 B  224  VAL HIS GLN SER VAL ALA THR GLU GLY PRO SER PRO SER          
SEQRES   4 B  224  PRO SER PRO SER LEU SER SER THR GLN SER ALA VAL SER          
SEQRES   5 B  224  LYS ALA GLY ALA GLY ALA VAL VAL PRO LYS LEU SER HIS          
SEQRES   6 B  224  LEU PRO ARG SER ARG ALA GLU TYR VAL VAL THR LYS LEU          
SEQRES   7 B  224  ASP ASP LEU ILE ASN TRP ALA ARG ARG SER SER LEU TRP          
SEQRES   8 B  224  PRO MET THR PHE GLY LEU ALA CYS CYS ALA VAL GLU MET          
SEQRES   9 B  224  MET HIS MET ALA ALA PRO ARG TYR ASP MET ASP ARG PHE          
SEQRES  10 B  224  GLY VAL VAL PHE ARG ALA SER PRO ARG GLN ALA ASP VAL          
SEQRES  11 B  224  MET ILE VAL ALA GLY THR LEU THR ASN LYS MET ALA PRO          
SEQRES  12 B  224  ALA LEU ARG LYS VAL TYR ASP GLN MET PRO GLU PRO ARG          
SEQRES  13 B  224  TYR VAL VAL SER MET GLY SER CYS ALA ASN GLY GLY GLY          
SEQRES  14 B  224  TYR TYR HIS TYR SER TYR SER VAL VAL ARG GLY CYS ASP          
SEQRES  15 B  224  ARG ILE VAL PRO VAL ASP ILE TYR VAL PRO GLY CYS PRO          
SEQRES  16 B  224  PRO THR ALA GLU ALA LEU LEU TYR GLY ILE LEU GLN LEU          
SEQRES  17 B  224  GLN ARG LYS ILE LYS ARG GLU GLN LYS LEU LYS ILE TRP          
SEQRES  18 B  224  TYR ARG ARG                                                  
SEQRES   1 C  263  MET ALA ALA ALA ALA ALA ARG VAL TRP CYS ARG GLY LEU          
SEQRES   2 C  263  LEU GLY ALA ALA SER VAL GLY ARG GLY ALA GLY ARG PRO          
SEQRES   3 C  263  SER VAL LEU TRP GLN HIS VAL ARG ARG GLU SER ALA ALA          
SEQRES   4 C  263  ALA ASP LYS ARG PRO THR VAL ARG PRO ARG SER ASP VAL          
SEQRES   5 C  263  THR HIS LYS GLN LEU SER ALA PHE GLY GLU TYR VAL ALA          
SEQRES   6 C  263  GLU ILE LEU PRO LYS TYR VAL GLN GLN VAL GLN VAL SER          
SEQRES   7 C  263  CYS LEU ASP GLU LEU GLU ILE CYS ILE HIS PRO ASP GLY          
SEQRES   8 C  263  VAL ILE PRO THR LEU THR PHE LEU ARG ASP HIS THR ASN          
SEQRES   9 C  263  ALA GLN PHE LYS SER LEU ALA ASP LEU THR ALA VAL ASP          
SEQRES  10 C  263  VAL PRO THR ARG GLN ASN ARG PHE GLU ILE VAL TYR ASN          
SEQRES  11 C  263  LEU LEU SER LEU ARG PHE ASN SER ARG ILE ARG VAL LYS          
SEQRES  12 C  263  THR TYR ALA ASP GLU LEU THR PRO ILE ASP SER ILE VAL          
SEQRES  13 C  263  SER VAL HIS ILE ALA ALA ASN TRP TYR GLU ARG GLU VAL          
SEQRES  14 C  263  TRP ASP MET PHE GLY VAL PHE PHE PHE ASN HIS PRO ASP          
SEQRES  15 C  263  LEU ARG ARG ILE LEU THR ASP TYR GLY PHE GLU GLY HIS          
SEQRES  16 C  263  PRO PHE ARG LYS ASP PHE PRO LEU THR GLY TYR VAL GLU          
SEQRES  17 C  263  LEU ARG TYR ASP ASP GLU VAL LYS ARG VAL VAL ALA GLU          
SEQRES  18 C  263  PRO VAL GLU LEU ALA GLN GLU PHE ARG LYS PHE ASP LEU          
SEQRES  19 C  263  ASN SER PRO TRP GLU ALA PHE PRO ALA TYR ARG GLN PRO          
SEQRES  20 C  263  PRO GLU SER LEU LYS LEU GLU ALA GLY ASP LYS LYS PRO          
SEQRES  21 C  263  GLU THR LYS                                                  
SEQRES   1 D  463  MET ALA ALA LEU ARG ALA LEU ARG CYS LEU ARG GLY VAL          
SEQRES   2 D  463  GLY ALA PRO VAL LEU ARG PRO GLY SER GLY ILE ARG LEU          
SEQRES   3 D  463  PRO SER GLN PRO SER ARG GLY ALA ARG GLN TRP GLN PRO          
SEQRES   4 D  463  ASP ILE GLU TRP ALA GLU GLN PHE SER GLY ALA VAL MET          
SEQRES   5 D  463  TYR PRO SER LYS GLU THR ALA HIS TRP LYS PRO PRO PRO          
SEQRES   6 D  463  TRP ASN ASP VAL ASP ILE LEU LYS GLU LYS ALA VAL THR          
SEQRES   7 D  463  ASN MET THR LEU ASN PHE GLY PRO GLN HIS PRO ALA ALA          
SEQRES   8 D  463  HIS GLY VAL LEU ARG LEU VAL LEU GLU LEU SER GLY GLU          
SEQRES   9 D  463  MET VAL ARG LYS CYS ASP PRO HIS ILE GLY LEU LEU HIS          
SEQRES  10 D  463  2MR GLY THR GLU LYS LEU ILE GLU TYR LYS THR TYR LEU          
SEQRES  11 D  463  GLN ALA LEU PRO TYR PHE ASP ARG LEU ASP TYR VAL SER          
SEQRES  12 D  463  MET MET CYS ASN GLU GLN ALA TYR SER ILE ALA VAL GLU          
SEQRES  13 D  463  LYS LEU LEU ASN ILE GLN PRO PRO PRO ARG ALA GLN TRP          
SEQRES  14 D  463  ILE ARG VAL LEU PHE GLY GLU ILE THR ARG ILE LEU ASN          
SEQRES  15 D  463  HIS ILE MET ALA VAL THR THR HIS ALA LEU ASP ILE GLY          
SEQRES  16 D  463  ALA MET THR PRO PHE PHE TRP MET PHE GLU GLU ARG GLU          
SEQRES  17 D  463  LYS MET PHE GLU PHE TYR GLU ARG VAL SER GLY ALA ARG          
SEQRES  18 D  463  MET HIS ALA ALA TYR ILE ARG PRO GLY GLY VAL HIS GLN          
SEQRES  19 D  463  ASP LEU PRO LEU GLY LEU LEU ASP ASP ILE TYR GLU PHE          
SEQRES  20 D  463  SER LYS ASN PHE SER LEU ARG ILE ASP GLU VAL GLU GLU          
SEQRES  21 D  463  MET LEU THR ASN ASN ARG ILE TRP ARG ASN ARG THR VAL          
SEQRES  22 D  463  ASP ILE GLY VAL VAL THR ALA GLU ASP ALA LEU ASN TYR          
SEQRES  23 D  463  GLY PHE SER GLY VAL MET LEU ARG GLY SER GLY ILE GLN          
SEQRES  24 D  463  TRP ASP LEU ARG LYS THR GLN PRO TYR ASP VAL TYR ASP          
SEQRES  25 D  463  GLN VAL GLU PHE ASP VAL PRO ILE GLY SER ARG GLY ASP          
SEQRES  26 D  463  CYS TYR ASP ARG TYR LEU CYS ARG VAL GLU GLU MET ARG          
SEQRES  27 D  463  GLN SER LEU ARG ILE ILE GLU GLN CYS LEU ASN LYS MET          
SEQRES  28 D  463  PRO PRO GLY GLU ILE LYS VAL ASP ASP ALA LYS VAL SER          
SEQRES  29 D  463  PRO PRO LYS ARG ALA GLU MET LYS THR SER MET GLU SER          
SEQRES  30 D  463  LEU ILE HIS HIS PHE LYS LEU TYR THR GLU GLY TYR GLN          
SEQRES  31 D  463  VAL PRO PRO GLY ALA THR TYR THR ALA ILE GLU ALA PRO          
SEQRES  32 D  463  LYS GLY GLU PHE GLY VAL TYR LEU VAL SER ASP GLY SER          
SEQRES  33 D  463  SER ARG PRO TYR ARG CYS LYS ILE LYS ALA PRO GLY PHE          
SEQRES  34 D  463  ALA HIS LEU ALA GLY LEU ASP LYS MET SER LYS GLY HIS          
SEQRES  35 D  463  MET LEU ALA ASP VAL VAL ALA ILE ILE GLY THR GLN ASP          
SEQRES  36 D  463  ILE VAL PHE GLY GLU ILE ASP ARG                              
SEQRES   1 E  248  MET PHE SER LEU ALA LEU ARG ALA ARG ALA THR GLY LEU          
SEQRES   2 E  248  ALA ALA GLN TRP GLY ARG HIS ALA ARG ASN LEU HIS LYS          
SEQRES   3 E  248  THR ALA VAL HIS ASN GLY ALA GLY GLY ALA LEU PHE VAL          
SEQRES   4 E  248  HIS ARG ASP THR PRO GLU ASN ASN PRO ASP THR PRO PHE          
SEQRES   5 E  248  ASP PHE THR PRO GLU ASN TYR LYS ARG ILE GLU ALA ILE          
SEQRES   6 E  248  VAL LYS ASN TYR PRO GLU GLY HIS GLN ALA ALA ALA VAL          
SEQRES   7 E  248  LEU PRO VAL LEU ASP LEU ALA GLN ARG GLN ASN GLY TRP          
SEQRES   8 E  248  LEU PRO ILE SER ALA MET ASN LYS VAL ALA GLU VAL LEU          
SEQRES   9 E  248  GLN VAL PRO PRO MET ARG VAL TYR GLU VAL ALA THR PHE          
SEQRES  10 E  248  TYR THR MET TYR ASN ARG LYS PRO VAL GLY LYS TYR HIS          
SEQRES  11 E  248  ILE GLN VAL CYS THR THR THR PRO CYS MET LEU ARG ASP          
SEQRES  12 E  248  SER ASP SER ILE LEU GLU THR LEU GLN ARG LYS LEU GLY          
SEQRES  13 E  248  ILE LYS VAL GLY GLU THR THR PRO ASP LYS LEU PHE THR          
SEQRES  14 E  248  LEU ILE GLU VAL GLU CYS LEU GLY ALA CYS VAL ASN ALA          
SEQRES  15 E  248  PRO MET VAL GLN ILE ASN ASP ASN TYR TYR GLU ASP LEU          
SEQRES  16 E  248  THR PRO LYS ASP ILE GLU GLU ILE ILE ASP GLU LEU LYS          
SEQRES  17 E  248  ALA GLY LYS VAL PRO LYS PRO GLY PRO ARG SER GLY ARG          
SEQRES  18 E  248  PHE CYS CYS GLU PRO ALA GLY GLY LEU THR SER LEU THR          
SEQRES  19 E  248  GLU PRO PRO LYS GLY PRO GLY PHE GLY VAL GLN ALA GLY          
SEQRES  20 E  248  LEU                                                          
SEQRES   1 F  428  THR SER PHE GLY SER LEU LYS ASP GLU ASP ARG ILE PHE          
SEQRES   2 F  428  THR ASN LEU TYR GLY ARG HIS ASP TRP ARG LEU LYS GLY          
SEQRES   3 F  428  ALA LEU ARG ARG GLY ASP TRP TYR LYS THR LYS GLU ILE          
SEQRES   4 F  428  LEU LEU LYS GLY PRO ASP TRP ILE LEU GLY GLU MET LYS          
SEQRES   5 F  428  THR SER GLY LEU ARG GLY ARG GLY GLY ALA GLY PHE PRO          
SEQRES   6 F  428  THR GLY LEU LYS TRP SER PHE MET ASN LYS PRO SER ASP          
SEQRES   7 F  428  GLY ARG PRO LYS TYR LEU VAL VAL ASN ALA ASP GLU GLY          
SEQRES   8 F  428  GLU PRO GLY THR CYS LYS ASP ARG GLU ILE MET ARG HIS          
SEQRES   9 F  428  ASP PRO HIS LYS LEU VAL GLU GLY CYS LEU VAL GLY GLY          
SEQRES  10 F  428  ARG ALA MET GLY ALA ARG ALA ALA TYR ILE TYR ILE ARG          
SEQRES  11 F  428  GLY GLU PHE TYR ASN GLU ALA SER ASN LEU GLN VAL ALA          
SEQRES  12 F  428  ILE ARG GLU ALA TYR GLU ALA GLY LEU ILE GLY LYS ASN          
SEQRES  13 F  428  ALA CYS GLY SER ASP TYR ASP PHE ASP VAL PHE VAL VAL          
SEQRES  14 F  428  ARG GLY ALA GLY ALA TYR ILE CYS GLY GLU GLU THR ALA          
SEQRES  15 F  428  LEU ILE GLU SER ILE GLU GLY LYS GLN GLY LYS PRO ARG          
SEQRES  16 F  428  LEU LYS PRO PRO PHE PRO ALA ASP VAL GLY VAL PHE GLY          
SEQRES  17 F  428  CYS PRO THR THR VAL ALA ASN VAL GLU THR VAL ALA VAL          
SEQRES  18 F  428  SER PRO THR ILE CYS ARG ARG GLY GLY THR TRP PHE ALA          
SEQRES  19 F  428  GLY PHE GLY ARG GLU ARG ASN SER GLY THR LYS LEU PHE          
SEQRES  20 F  428  ASN ILE SER GLY HIS VAL ASN HIS PRO CYS THR VAL GLU          
SEQRES  21 F  428  GLU GLU MET SER VAL PRO LEU LYS GLU LEU ILE GLU LYS          
SEQRES  22 F  428  HIS ALA GLY GLY VAL THR GLY GLY TRP ASP ASN LEU LEU          
SEQRES  23 F  428  ALA VAL ILE PRO GLY GLY SER SER THR PRO LEU ILE PRO          
SEQRES  24 F  428  LYS SER VAL CYS GLU THR VAL LEU MET ASP PHE ASP ALA          
SEQRES  25 F  428  LEU VAL GLN ALA GLN THR GLY LEU GLY THR ALA ALA VAL          
SEQRES  26 F  428  ILE VAL MET ASP ARG SER THR ASP ILE VAL LYS ALA ILE          
SEQRES  27 F  428  ALA ARG LEU ILE GLU PHE TYR LYS HIS GLU SER CYS GLY          
SEQRES  28 F  428  GLN CYS THR PRO CYS ARG GLU GLY VAL ASP TRP MET ASN          
SEQRES  29 F  428  LYS VAL MET ALA ARG PHE VAL LYS GLY ASP ALA ARG PRO          
SEQRES  30 F  428  ALA GLU ILE ASP SER LEU TRP GLU ILE SER LYS GLN ILE          
SEQRES  31 F  428  GLU GLY HIS THR ILE CYS ALA LEU GLY ASP GLY ALA ALA          
SEQRES  32 F  428  TRP PRO VAL GLN GLY LEU ILE ARG HIS PHE ARG PRO GLU          
SEQRES  33 F  428  LEU GLU ASP ARG MET GLN ARG PHE ALA GLN GLN HIS              
SEQRES   1 G  727  MET LEU ARG ILE PRO ILE LYS ARG ALA LEU ILE GLY LEU          
SEQRES   2 G  727  SER ASN SER PRO LYS GLY TYR VAL ARG THR THR GLY THR          
SEQRES   3 G  727  ALA ALA SER ASN LEU ILE GLU VAL PHE VAL ASP GLY GLN          
SEQRES   4 G  727  SER VAL MET VAL GLU PRO GLY THR THR VAL LEU GLN ALA          
SEQRES   5 G  727  CYS GLU LYS VAL GLY MET GLN ILE PRO ARG PHE CYS TYR          
SEQRES   6 G  727  HIS GLU ARG LEU SER VAL ALA GLY ASN CYS ARG MET CYS          
SEQRES   7 G  727  LEU VAL GLU ILE GLU LYS ALA PRO LYS VAL VAL ALA ALA          
SEQRES   8 G  727  CYS ALA MET PRO VAL MET LYS GLY TRP ASN ILE LEU THR          
SEQRES   9 G  727  ASN SER GLU LYS SER LYS LYS ALA ARG GLU GLY VAL MET          
SEQRES  10 G  727  GLU PHE LEU LEU ALA ASN HIS PRO LEU ASP CYS PRO ILE          
SEQRES  11 G  727  CYS ASP GLN GLY GLY GLU CYS ASP LEU GLN ASP GLN SER          
SEQRES  12 G  727  MET MET PHE GLY SER ASP ARG SER ARG PHE LEU GLU GLY          
SEQRES  13 G  727  LYS ARG ALA VAL GLU ASP LYS ASN ILE GLY PRO LEU VAL          
SEQRES  14 G  727  LYS THR ILE MET THR ARG CYS ILE GLN CYS THR ARG CYS          
SEQRES  15 G  727  ILE ARG PHE ALA SER GLU ILE ALA GLY VAL ASP ASP LEU          
SEQRES  16 G  727  GLY THR THR GLY ARG GLY ASN ASP MET GLN VAL GLY THR          
SEQRES  17 G  727  TYR ILE GLU LYS MET PHE MET SER GLU LEU SER GLY ASN          
SEQRES  18 G  727  VAL ILE ASP ILE CYS PRO VAL GLY ALA LEU THR SER LYS          
SEQRES  19 G  727  PRO TYR ALA PHE THR ALA ARG PRO TRP GLU THR ARG LYS          
SEQRES  20 G  727  THR GLU SER ILE ASP VAL MET ASP ALA VAL GLY SER ASN          
SEQRES  21 G  727  ILE VAL VAL SER THR ARG THR GLY GLU VAL MET ARG ILE          
SEQRES  22 G  727  LEU PRO ARG MET HIS GLU ASP ILE ASN GLU GLU TRP ILE          
SEQRES  23 G  727  SER ASP LYS THR ARG PHE ALA TYR ASP GLY LEU LYS ARG          
SEQRES  24 G  727  GLN ARG LEU THR GLU PRO MET VAL ARG ASN GLU LYS GLY          
SEQRES  25 G  727  LEU LEU THR TYR THR SER TRP GLU ASP ALA LEU SER ARG          
SEQRES  26 G  727  VAL ALA GLY MET LEU GLN ASN PHE GLU GLY ASN ALA VAL          
SEQRES  27 G  727  ALA ALA ILE ALA GLY GLY LEU VAL ASP ALA GLU ALA LEU          
SEQRES  28 G  727  VAL ALA LEU LYS ASP LEU LEU ASN LYS VAL ASP SER ASP          
SEQRES  29 G  727  ASN LEU CYS THR GLU GLU ILE PHE PRO THR GLU GLY ALA          
SEQRES  30 G  727  GLY THR ASP LEU ARG SER ASN TYR LEU LEU ASN THR THR          
SEQRES  31 G  727  ILE ALA GLY VAL GLU GLU ALA ASP VAL VAL LEU LEU VAL          
SEQRES  32 G  727  GLY THR ASN PRO ARG PHE GLU ALA PRO LEU PHE ASN ALA          
SEQRES  33 G  727  ARG ILE ARG LYS SER TRP LEU HIS ASN ASP LEU LYS VAL          
SEQRES  34 G  727  ALA LEU ILE GLY SER PRO VAL ASP LEU THR TYR ARG TYR          
SEQRES  35 G  727  ASP HIS LEU GLY ASP SER PRO LYS ILE LEU GLN ASP ILE          
SEQRES  36 G  727  ALA SER GLY ARG HIS SER PHE CYS GLU VAL LEU LYS ASP          
SEQRES  37 G  727  ALA LYS LYS PRO MET VAL VAL LEU GLY SER SER ALA LEU          
SEQRES  38 G  727  GLN ARG ASP ASP GLY ALA ALA ILE LEU VAL ALA VAL SER          
SEQRES  39 G  727  ASN MET VAL GLN LYS ILE ARG VAL THR THR GLY VAL ALA          
SEQRES  40 G  727  ALA GLU TRP LYS VAL MET ASN ILE LEU HIS ARG ILE ALA          
SEQRES  41 G  727  SER GLN VAL ALA ALA LEU ASP LEU GLY TYR LYS PRO GLY          
SEQRES  42 G  727  VAL GLU ALA ILE ARG LYS ASN PRO PRO LYS MET LEU PHE          
SEQRES  43 G  727  LEU LEU GLY ALA ASP GLY GLY CYS ILE THR ARG GLN ASP          
SEQRES  44 G  727  LEU PRO LYS ASP CYS PHE ILE VAL TYR GLN GLY HIS HIS          
SEQRES  45 G  727  GLY ASP VAL GLY ALA PRO MET ALA ASP VAL ILE LEU PRO          
SEQRES  46 G  727  GLY ALA ALA TYR THR GLU LYS SER ALA THR TYR VAL ASN          
SEQRES  47 G  727  THR GLU GLY ARG ALA GLN GLN THR LYS VAL ALA VAL THR          
SEQRES  48 G  727  PRO PRO GLY LEU ALA ARG GLU ASP TRP LYS ILE ILE ARG          
SEQRES  49 G  727  ALA LEU SER GLU ILE ALA GLY ILE THR LEU PRO TYR ASP          
SEQRES  50 G  727  THR LEU ASP GLN VAL ARG ASN ARG LEU GLU GLU VAL SER          
SEQRES  51 G  727  PRO ASN LEU VAL ARG TYR ASP ASP ILE GLU GLU THR ASN          
SEQRES  52 G  727  TYR PHE GLN GLN ALA SER GLU LEU ALA LYS LEU VAL ASN          
SEQRES  53 G  727  GLN GLU VAL LEU ALA ASP PRO LEU VAL PRO PRO GLN LEU          
SEQRES  54 G  727  THR ILE LYS ASP PHE TYR MET THR ASP SER ILE SER ARG          
SEQRES  55 G  727  ALA SER GLN THR MET ALA LYS CYS VAL LYS ALA VAL THR          
SEQRES  56 G  727  GLU GLY ALA GLN ALA VAL GLU GLU PRO SER ILE CYS              
SEQRES   1 H  318  FME PHE PHE ILE ASN ILE LEU THR LEU LEU VAL PRO ILE          
SEQRES   2 H  318  LEU ILE ALA MET ALA PHE LEU THR LEU VAL GLU ARG LYS          
SEQRES   3 H  318  ILE LEU GLY TYR MET GLN LEU ARG LYS GLY PRO ASN ILE          
SEQRES   4 H  318  VAL GLY PRO TYR GLY ILE LEU GLN PRO PHE ALA ASP ALA          
SEQRES   5 H  318  MET LYS LEU PHE MET LYS GLU PRO MET ARG PRO LEU THR          
SEQRES   6 H  318  THR SER MET SER LEU PHE ILE ILE ALA PRO THR LEU SER          
SEQRES   7 H  318  LEU THR LEU ALA LEU SER LEU TRP VAL PRO LEU PRO MET          
SEQRES   8 H  318  PRO HIS PRO LEU ILE ASN LEU ASN LEU GLY ILE LEU PHE          
SEQRES   9 H  318  ILE LEU ALA THR SER SER LEU SER VAL TYR SER ILE LEU          
SEQRES  10 H  318  TRP SER GLY TRP ALA SER ASN SER LYS TYR SER LEU PHE          
SEQRES  11 H  318  GLY ALA LEU ARG ALA VAL ALA GLN THR ILE SER TYR GLU          
SEQRES  12 H  318  VAL THR MET ALA ILE ILE LEU LEU SER VAL LEU LEU MET          
SEQRES  13 H  318  ASN GLY SER TYR SER LEU GLN THR LEU ILE THR THR GLN          
SEQRES  14 H  318  GLU HIS MET TRP LEU LEU LEU PRO ALA TRP PRO MET ALA          
SEQRES  15 H  318  MET MET TRP PHE ILE SER THR LEU ALA GLU THR ASN ARG          
SEQRES  16 H  318  ALA PRO PHE ASP LEU THR GLU GLY GLU SER GLU LEU VAL          
SEQRES  17 H  318  SER GLY PHE ASN VAL GLU TYR ALA ALA GLY PRO PHE ALA          
SEQRES  18 H  318  LEU PHE PHE MET ALA GLU TYR THR ASN ILE ILE LEU MET          
SEQRES  19 H  318  ASN ALA LEU THR THR ILE ILE PHE LEU GLY PRO LEU TYR          
SEQRES  20 H  318  TYR ILE ASN LEU PRO GLU LEU TYR SER THR ASN PHE MET          
SEQRES  21 H  318  MET GLU ALA LEU LEU LEU SER SER THR PHE LEU TRP ILE          
SEQRES  22 H  318  ARG ALA SER TYR PRO ARG PHE ARG TYR ASP GLN LEU MET          
SEQRES  23 H  318  HIS LEU LEU TRP LYS ASN PHE LEU PRO LEU THR LEU ALA          
SEQRES  24 H  318  LEU CYS MET TRP HIS ILE SER LEU PRO ILE PHE THR ALA          
SEQRES  25 H  318  GLY VAL PRO PRO TYR MET                                      
SEQRES   1 I  212  MET TYR ARG LEU SER SER SER MET LEU PRO ARG ALA LEU          
SEQRES   2 I  212  ALA GLN ALA MET ARG THR GLY HIS LEU ASN GLY GLN SER          
SEQRES   3 I  212  LEU HIS SER SER ALA VAL ALA ALA THR TYR LYS TYR VAL          
SEQRES   4 I  212  ASN LYS LYS GLU GLN GLU SER GLU VAL ASP MET LYS SER          
SEQRES   5 I  212  ALA THR ASP ASN ALA ALA ARG ILE LEU MET TRP THR GLU          
SEQRES   6 I  212  LEU ILE ARG GLY LEU GLY MET THR LEU SER TYR LEU PHE          
SEQRES   7 I  212  ARG GLU PRO ALA THR ILE ASN TYR PRO PHE GLU LYS GLY          
SEQRES   8 I  212  PRO LEU SER PRO ARG PHE ARG GLY GLU HIS ALA LEU ARG          
SEQRES   9 I  212  ARG TYR PRO SER GLY GLU GLU ARG CYS ILE ALA CYS LYS          
SEQRES  10 I  212  LEU CYS GLU ALA ILE CYS PRO ALA GLN ALA ILE THR ILE          
SEQRES  11 I  212  GLU ALA GLU PRO ARG ALA ASP GLY SER ARG ARG THR THR          
SEQRES  12 I  212  ARG TYR ASP ILE ASP MET THR LYS CYS ILE TYR CYS GLY          
SEQRES  13 I  212  PHE CYS GLN GLU ALA CYS PRO VAL ASP ALA ILE VAL GLU          
SEQRES  14 I  212  GLY PRO ASN PHE GLU PHE SER THR GLU THR HIS GLU GLU          
SEQRES  15 I  212  LEU LEU TYR ASN LYS GLU LYS LEU LEU ASN ASN GLY ASP          
SEQRES  16 I  212  LYS TRP GLU ALA GLU ILE ALA ALA ASN ILE GLN ALA ASP          
SEQRES  17 I  212  TYR LEU TYR ARG                                              
SEQRES   1 J  172  FME ASN ASN TYR ILE PHE VAL LEU SER SER LEU PHE LEU          
SEQRES   2 J  172  VAL GLY CYS LEU GLY LEU ALA LEU LYS PRO SER PRO ILE          
SEQRES   3 J  172  TYR GLY GLY LEU GLY LEU ILE VAL SER GLY PHE VAL GLY          
SEQRES   4 J  172  CYS LEU MET VAL LEU GLY PHE GLY GLY SER PHE LEU GLY          
SEQRES   5 J  172  LEU MET VAL PHE LEU ILE TYR LEU GLY GLY MET LEU VAL          
SEQRES   6 J  172  VAL PHE GLY TYR THR THR ALA MET ALA THR GLU GLU TYR          
SEQRES   7 J  172  PRO GLU THR TRP GLY SER ASN TRP LEU ILE LEU GLY PHE          
SEQRES   8 J  172  LEU VAL LEU GLY VAL ILE MET GLU VAL PHE LEU ILE CYS          
SEQRES   9 J  172  VAL LEU ASN TYR TYR ASP GLU VAL GLY VAL ILE ASN LEU          
SEQRES  10 J  172  ASP GLY LEU GLY ASP TRP LEU MET TYR GLU VAL ASP ASP          
SEQRES  11 J  172  VAL GLY VAL MET LEU GLU GLY GLY ILE GLY VAL ALA ALA          
SEQRES  12 J  172  MET TYR SER CYS ALA THR TRP MET MET VAL VAL ALA GLY          
SEQRES  13 J  172  TRP SER LEU PHE ALA GLY ILE PHE ILE ILE ILE GLU ILE          
SEQRES  14 J  172  THR ARG ASP                                                  
SEQRES   1 K   98  FME PRO SER THR PHE PHE ASN LEU THR MET ALA PHE SER          
SEQRES   2 K   98  LEU SER LEU LEU GLY THR LEU MET PHE ARG SER HIS LEU          
SEQRES   3 K   98  MET SER THR LEU LEU CYS LEU GLU GLY MET VAL LEU SER          
SEQRES   4 K   98  LEU PHE ILE MET THR SER VAL THR SER LEU ASN SER ASN          
SEQRES   5 K   98  SER MET SER SER MET PRO ILE PRO ILE THR ILE LEU VAL          
SEQRES   6 K   98  PHE ALA ALA CYS GLU ALA ALA VAL GLY LEU ALA LEU LEU          
SEQRES   7 K   98  VAL LYS VAL SER ASN THR TYR GLY THR ASP TYR VAL GLN          
SEQRES   8 K   98  ASN LEU ASN LEU LEU GLN CYS                                  
SEQRES   1 L  607  FME ASN ILE PHE THR THR SER ILE LEU LEU ILE PHE ILE          
SEQRES   2 L  607  LEU LEU LEU SER PRO ILE LEU ILE SER MET SER ASN LEU          
SEQRES   3 L  607  ILE LYS HIS ILE ASN PHE PRO LEU TYR THR THR THR SER          
SEQRES   4 L  607  ILE LYS PHE SER PHE ILE ILE SER LEU LEU PRO LEU LEU          
SEQRES   5 L  607  MET PHE PHE HIS ASN ASN MET GLU TYR MET ILE THR THR          
SEQRES   6 L  607  TRP HIS TRP VAL THR MET ASN SER MET GLU LEU LYS MET          
SEQRES   7 L  607  SER PHE LYS THR ASP PHE PHE SER ILE LEU PHE THR SER          
SEQRES   8 L  607  VAL ALA LEU PHE VAL THR TRP SER ILE MET GLN PHE SER          
SEQRES   9 L  607  SER TRP TYR MET HIS SER ASP PRO ASN ILE ASN ARG PHE          
SEQRES  10 L  607  ILE LYS TYR LEU THR LEU PHE LEU ILE THR MET LEU ILE          
SEQRES  11 L  607  LEU THR SER ALA ASN ASN MET PHE GLN LEU PHE ILE GLY          
SEQRES  12 L  607  TRP GLU GLY VAL GLY ILE MET SER PHE LEU LEU ILE GLY          
SEQRES  13 L  607  TRP TRP TYR GLY ARG THR ASP ALA ASN THR ALA ALA LEU          
SEQRES  14 L  607  GLN ALA ILE LEU TYR ASN ARG ILE GLY ASP ILE GLY PHE          
SEQRES  15 L  607  ILE LEU ALA MET VAL TRP PHE SER LEU ASN MET ASN SER          
SEQRES  16 L  607  TRP GLU LEU GLN GLN ILE MET PHE SER ASN ASN ASN ASP          
SEQRES  17 L  607  ASN LEU ILE PRO LEU MET GLY LEU LEU ILE ALA ALA THR          
SEQRES  18 L  607  GLY LYS SER ALA GLN PHE GLY LEU HIS PRO TRP LEU PRO          
SEQRES  19 L  607  SER ALA MET GLU GLY PRO THR PRO VAL SER ALA LEU LEU          
SEQRES  20 L  607  HIS SER SER THR MET VAL VAL ALA GLY ILE PHE LEU LEU          
SEQRES  21 L  607  VAL ARG PHE HIS PRO LEU THR THR ASN ASN ASN PHE ILE          
SEQRES  22 L  607  LEU THR THR MET LEU CYS LEU GLY ALA LEU THR THR LEU          
SEQRES  23 L  607  PHE THR ALA ILE CYS ALA LEU THR GLN ASN ASP ILE LYS          
SEQRES  24 L  607  LYS ILE ILE ALA PHE SER THR SER SER GLN LEU GLY LEU          
SEQRES  25 L  607  MET MET VAL THR LEU GLY MET ASN GLN PRO HIS LEU ALA          
SEQRES  26 L  607  PHE LEU HIS ILE CYS THR HIS ALA PHE PHE LYS ALA MET          
SEQRES  27 L  607  LEU PHE MET CYS SER GLY SER ILE ILE HIS SER LEU ALA          
SEQRES  28 L  607  ASP GLU GLN ASP ILE ARG LYS MET GLY ASN ILE THR LYS          
SEQRES  29 L  607  ILE MET PRO PHE THR SER SER CYS LEU VAL ILE GLY SER          
SEQRES  30 L  607  LEU ALA LEU THR GLY MET PRO PHE LEU THR GLY PHE TYR          
SEQRES  31 L  607  SER LYS ASP LEU ILE ILE GLU ALA ILE ASN THR CYS ASN          
SEQRES  32 L  607  THR ASN ALA TRP ALA LEU LEU ILE THR LEU ILE ALA THR          
SEQRES  33 L  607  SER MET THR ALA MET TYR SER MET ARG ILE ILE TYR PHE          
SEQRES  34 L  607  VAL THR MET THR LYS PRO ARG PHE PRO PRO LEU ILE SER          
SEQRES  35 L  607  ILE ASN GLU ASN ASP PRO ASP LEU MET ASN PRO ILE LYS          
SEQRES  36 L  607  ARG LEU ALA PHE GLY SER ILE PHE ALA GLY PHE VAL ILE          
SEQRES  37 L  607  SER TYR ASN ILE PRO PRO THR SER ILE PRO VAL LEU THR          
SEQRES  38 L  607  MET PRO TRP PHE LEU LYS THR THR ALA LEU ILE ILE SER          
SEQRES  39 L  607  VAL LEU GLY PHE LEU ILE ALA LEU GLU LEU ASN ASN LEU          
SEQRES  40 L  607  THR MET LYS LEU SER MET ASN LYS ALA ASN PRO TYR SER          
SEQRES  41 L  607  SER PHE SER THR LEU LEU GLY PHE PHE PRO SER ILE ILE          
SEQRES  42 L  607  HIS ARG ILE THR PRO MET LYS SER LEU ASN LEU SER LEU          
SEQRES  43 L  607  LYS THR SER LEU THR LEU LEU ASP LEU ILE TRP LEU GLU          
SEQRES  44 L  607  LYS THR ILE PRO LYS SER THR SER THR LEU HIS THR ASN          
SEQRES  45 L  607  MET THR THR LEU THR THR ASN GLN LYS GLY LEU ILE LYS          
SEQRES  46 L  607  LEU TYR PHE MET SER PHE LEU ILE ASN ILE ILE LEU ILE          
SEQRES  47 L  607  ILE ILE LEU TYR SER ILE ASN LEU GLU                          
SEQRES   1 M  459  FME LEU LYS ILE ILE LEU PRO SER LEU MET LEU LEU PRO          
SEQRES   2 M  459  LEU THR TRP LEU SER SER PRO LYS LYS THR TRP THR ASN          
SEQRES   3 M  459  VAL THR SER TYR SER PHE LEU ILE SER LEU THR SER LEU          
SEQRES   4 M  459  THR LEU LEU TRP GLN THR ASP GLU ASN TYR LYS ASN PHE          
SEQRES   5 M  459  SER ASN MET PHE SER SER ASP PRO LEU SER THR PRO LEU          
SEQRES   6 M  459  ILE ILE LEU THR ALA TRP LEU LEU PRO LEU MET LEU MET          
SEQRES   7 M  459  ALA SER GLN ASN HIS LEU LYS LYS ASP ASN ASN VAL LEU          
SEQRES   8 M  459  GLN LYS LEU TYR ILE SER MET LEU ILE SER LEU GLN ILE          
SEQRES   9 M  459  LEU LEU ILE MET THR PHE SER ALA THR GLU LEU ILE MET          
SEQRES  10 M  459  PHE TYR ILE LEU PHE GLU ALA THR LEU ILE PRO THR LEU          
SEQRES  11 M  459  ILE ILE ILE THR ARG TRP GLY ASN GLN THR GLU ARG LEU          
SEQRES  12 M  459  ASN ALA GLY ILE TYR PHE LEU PHE TYR THR LEU ILE GLY          
SEQRES  13 M  459  SER ILE PRO LEU LEU ILE ALA LEU ILE LEU ILE GLN ASN          
SEQRES  14 M  459  HIS VAL GLY THR LEU ASN LEU MET ILE LEU SER PHE THR          
SEQRES  15 M  459  THR HIS THR LEU ASP ALA SER TRP SER ASN ASN LEU LEU          
SEQRES  16 M  459  TRP LEU ALA CYS MET MET ALA PHE LEU ILE LYS MET PRO          
SEQRES  17 M  459  LEU TYR GLY VAL HIS LEU TRP LEU PRO LYS ALA HIS VAL          
SEQRES  18 M  459  GLU ALA PRO ILE ALA GLY SER MET ILE LEU ALA ALA ILE          
SEQRES  19 M  459  LEU LEU LYS LEU GLY SER TYR GLY MET ILE ARG ILE SER          
SEQRES  20 M  459  ILE ILE LEU ASP PRO LEU THR LYS TYR MET ALA TYR PRO          
SEQRES  21 M  459  PHE ILE LEU LEU SER LEU TRP GLY MET ILE MET THR SER          
SEQRES  22 M  459  SER ILE CYS LEU ARG GLN THR ASP LEU LYS SER LEU ILE          
SEQRES  23 M  459  ALA TYR SER SER VAL SER HIS MET ALA LEU VAL ILE ALA          
SEQRES  24 M  459  SER ILE MET ILE GLN THR PRO TRP SER PHE MET GLY ALA          
SEQRES  25 M  459  THR MET LEU MET ILE ALA HIS GLY LEU THR SER SER LEU          
SEQRES  26 M  459  LEU PHE CYS LEU ALA ASN SER ASN TYR GLU ARG ILE HIS          
SEQRES  27 M  459  SER ARG THR MET ILE MET ALA ARG GLY LEU GLN MET VAL          
SEQRES  28 M  459  PHE PRO LEU MET ALA THR TRP TRP LEU MET ALA SER LEU          
SEQRES  29 M  459  ALA ASN LEU ALA LEU PRO PRO SER ILE ASN LEU MET GLY          
SEQRES  30 M  459  GLU LEU PHE ILE THR MET SER LEU PHE SER TRP SER ASN          
SEQRES  31 M  459  PHE THR ILE ILE LEU MET GLY ILE ASN ILE ILE ILE THR          
SEQRES  32 M  459  GLY MET TYR SER MET TYR MET ILE ILE THR THR GLN ARG          
SEQRES  33 M  459  GLY LYS LEU THR ASN HIS MET ILE ASN LEU GLN PRO SER          
SEQRES  34 M  459  HIS THR ARG GLU LEU THR LEU MET ALA LEU HIS MET ILE          
SEQRES  35 M  459  PRO LEU ILE LEU LEU THR THR SER PRO LYS LEU ILE THR          
SEQRES  36 M  459  GLY LEU THR MET                                              
SEQRES   1 N  345  FME ASN PRO ILE THR LEU ALA ILE ILE TYR PHE THR ILE          
SEQRES   2 N  345  PHE LEU GLY PRO VAL ILE THR MET SER SER THR ASN LEU          
SEQRES   3 N  345  MET LEU MET TRP VAL GLY LEU GLU PHE SER LEU LEU ALA          
SEQRES   4 N  345  ILE ILE PRO MET LEU ILE ASN LYS LYS ASN PRO ARG SER          
SEQRES   5 N  345  THR GLU ALA ALA THR LYS TYR PHE VAL THR GLN ALA THR          
SEQRES   6 N  345  ALA SER MET ILE ILE LEU LEU ALA ILE VAL LEU ASN TYR          
SEQRES   7 N  345  LYS GLN LEU GLY THR TRP MET PHE GLN GLN GLN THR ASN          
SEQRES   8 N  345  GLY LEU ILE LEU ASN MET THR LEU MET ALA LEU SER MET          
SEQRES   9 N  345  LYS LEU GLY LEU ALA PRO PHE HIS PHE TRP LEU PRO GLU          
SEQRES  10 N  345  VAL THR GLN GLY ILE PRO LEU HIS MET GLY LEU ILE LEU          
SEQRES  11 N  345  LEU THR TRP GLN LYS ILE ALA PRO LEU SER ILE LEU ILE          
SEQRES  12 N  345  GLN ILE TYR PRO LEU LEU ASN SER THR ILE ILE LEU MET          
SEQRES  13 N  345  LEU ALA ILE THR SER ILE PHE MET GLY ALA TRP GLY GLY          
SEQRES  14 N  345  LEU ASN GLN THR GLN MET ARG LYS ILE MET ALA TYR SER          
SEQRES  15 N  345  SER ILE ALA HIS MET GLY TRP MET LEU ALA ILE LEU PRO          
SEQRES  16 N  345  TYR ASN PRO SER LEU THR LEU LEU ASN LEU MET ILE TYR          
SEQRES  17 N  345  ILE ILE LEU THR ALA PRO MET PHE MET ALA LEU MET LEU          
SEQRES  18 N  345  ASN ASN SER MET THR ILE ASN SER ILE SER LEU LEU TRP          
SEQRES  19 N  345  ASN LYS THR PRO ALA MET LEU THR MET ILE SER LEU MET          
SEQRES  20 N  345  LEU LEU SER LEU GLY GLY LEU PRO PRO LEU THR GLY PHE          
SEQRES  21 N  345  LEU PRO LYS TRP ILE ILE ILE THR GLU LEU MET LYS ASN          
SEQRES  22 N  345  ASN CYS LEU ILE MET ALA THR LEU MET ALA MET MET ALA          
SEQRES  23 N  345  LEU LEU ASN LEU PHE PHE TYR THR ARG LEU ILE TYR SER          
SEQRES  24 N  345  THR SER LEU THR MET PHE PRO THR ASN ASN ASN SER LYS          
SEQRES  25 N  345  MET MET THR HIS GLN THR LYS THR LYS PRO ASN LEU MET          
SEQRES  26 N  345  PHE SER THR LEU ALA ILE MET SER THR MET THR LEU PRO          
SEQRES  27 N  345  LEU ALA PRO GLN LEU ILE THR                                  
SEQRES   1 O  355  MET ALA LEU ARG LEU LEU ARG LEU VAL PRO ALA SER ALA          
SEQRES   2 O  355  PRO ALA ARG GLY LEU ALA ALA GLY ALA GLN ARG VAL GLY          
SEQRES   3 O  355  ARG ILE HIS THR SER VAL HIS CYS LYS LEU ARG TYR GLY          
SEQRES   4 O  355  LEU LEU ALA ALA ILE LEU GLY ASP LYS THR THR LYS LYS          
SEQRES   5 O  355  LEU HIS GLU TYR SER ARG VAL ILE THR VAL ASP GLY ASN          
SEQRES   6 O  355  ILE CYS SER GLY LYS ASN LYS LEU ALA LYS GLU ILE ALA          
SEQRES   7 O  355  GLN GLN LEU GLY MET LYS HIS TYR PRO GLU ALA GLY ILE          
SEQRES   8 O  355  GLN TYR SER SER THR THR THR GLY ASP GLY ARG PRO LEU          
SEQRES   9 O  355  ASP ILE GLU PHE SER GLY SER CYS SER LEU GLU LYS PHE          
SEQRES  10 O  355  TYR ASP ASP PRO LYS SER ASN ASP GLY ASN SER TYR ARG          
SEQRES  11 O  355  LEU GLN SER TRP LEU TYR ALA SER ARG LEU LEU GLN TYR          
SEQRES  12 O  355  ALA ASP ALA LEU GLU HIS LEU LEU SER THR GLY GLN GLY          
SEQRES  13 O  355  VAL VAL LEU GLU ARG SER ILE TYR SER ASP PHE VAL PHE          
SEQRES  14 O  355  LEU GLU ALA MET TYR ASN GLN GLY TYR ILE ARG LYS GLN          
SEQRES  15 O  355  CYS VAL ASP HIS TYR ASN GLU ILE LYS ARG LEU THR LEU          
SEQRES  16 O  355  PRO GLU TYR LEU PRO PRO HIS ALA VAL ILE TYR ILE ASP          
SEQRES  17 O  355  VAL PRO VAL PRO GLU VAL GLN SER ARG ILE GLN LYS LYS          
SEQRES  18 O  355  GLY ASP PRO HIS GLU MET LYS VAL THR SER ALA TYR LEU          
SEQRES  19 O  355  GLN ASP ILE GLU ASN ALA TYR LYS LYS THR PHE LEU PRO          
SEQRES  20 O  355  LYS MET SER GLU MET CYS GLU VAL LEU VAL TYR ASP SER          
SEQRES  21 O  355  TRP GLU ALA GLU ASP PRO THR LYS VAL VAL GLU ASP ILE          
SEQRES  22 O  355  GLU TYR LEU LYS TYR ASN LYS GLY PRO TRP LEU LYS GLN          
SEQRES  23 O  355  ASP ASP TRP THR PHE HIS TYR LEU ARG MET LEU VAL GLN          
SEQRES  24 O  355  ASP LYS THR GLU VAL LEU ASN TYR THR THR ILE PRO VAL          
SEQRES  25 O  355  TYR LEU PRO GLU ILE THR ILE GLY ALA HIS GLN GLY SER          
SEQRES  26 O  355  ARG ILE TYR ASN SER PHE ARG GLU LEU PRO GLY ARG LYS          
SEQRES  27 O  355  TYR ALA PRO GLY TYR ASN ALA GLU VAL GLY ASP LYS TRP          
SEQRES  28 O  355  ILE TRP LEU LYS                                              
SEQRES   1 P  377  MET ALA ALA ALA VAL ARG PHE ARG VAL VAL ARG ALA LEU          
SEQRES   2 P  377  PRO MET SER ARG PRO ALA ILE THR ALA ALA ALA THR SER          
SEQRES   3 P  377  VAL PHE CYS GLY SER SER HIS ARG GLN LEU HIS HIS ALA          
SEQRES   4 P  377  VAL ILE PRO HIS GLY LYS GLY GLY ARG SER SER VAL SER          
SEQRES   5 P  377  GLY VAL VAL ALA THR VAL PHE GLY ALA THR GLY PHE LEU          
SEQRES   6 P  377  GLY ARG TYR VAL VAL ASN HIS LEU GLY ARG MET GLY SER          
SEQRES   7 P  377  GLN VAL ILE ILE PRO TYR ARG CYS ASP VAL TYR ASP ILE          
SEQRES   8 P  377  MET HIS LEU ARG LEU MET GLY ASP LEU GLY GLN LEU THR          
SEQRES   9 P  377  PHE LEU GLU TRP ASP ALA ARG ASP LYS ASP SER ILE ARG          
SEQRES  10 P  377  LYS ALA VAL GLN HIS SER ASN VAL VAL ILE ASN LEU ILE          
SEQRES  11 P  377  GLY ARG GLU TRP GLU THR ARG ASN PHE ASP PHE GLU ASP          
SEQRES  12 P  377  VAL PHE VAL ASN ILE PRO ARG ALA ILE ALA GLN ALA SER          
SEQRES  13 P  377  LYS GLU ALA GLY VAL GLU ARG PHE ILE HIS VAL SER HIS          
SEQRES  14 P  377  LEU ASN ALA SER MET LYS SER SER SER LYS SER LEU ARG          
SEQRES  15 P  377  SER LYS ALA VAL GLY GLU LYS GLU VAL ARG SER VAL PHE          
SEQRES  16 P  377  PRO GLU ALA ILE ILE ILE ARG PRO SER ASP ILE PHE GLY          
SEQRES  17 P  377  ARG GLU ASP ARG PHE LEU ASN HIS PHE ALA ASN TYR ARG          
SEQRES  18 P  377  TRP PHE LEU ALA VAL PRO LEU VAL SER LEU GLY PHE LYS          
SEQRES  19 P  377  THR VAL LYS GLN PRO VAL TYR VAL ALA ASP VAL SER LYS          
SEQRES  20 P  377  GLY ILE VAL ASN ALA THR LYS ASP PRO ASP ALA VAL GLY          
SEQRES  21 P  377  LYS THR PHE ALA PHE THR GLY PRO ASN ARG TYR LEU LEU          
SEQRES  22 P  377  PHE HIS LEU VAL LYS TYR ILE PHE GLY MET THR HIS ARG          
SEQRES  23 P  377  THR PHE ILE PRO TYR PRO LEU PRO LEU PHE VAL TYR SER          
SEQRES  24 P  377  TRP ILE GLY LYS LEU PHE GLY LEU SER PRO PHE GLU PRO          
SEQRES  25 P  377  TRP THR THR LYS ASP LYS VAL GLU ARG ILE HIS ILE SER          
SEQRES  26 P  377  ASP VAL MET PRO THR ASP LEU PRO GLY LEU GLU ASP LEU          
SEQRES  27 P  377  GLY VAL GLN PRO THR PRO LEU GLU LEU LYS SER ILE GLU          
SEQRES  28 P  377  VAL LEU ARG ARG HIS ARG THR TYR ARG TRP LEU SER SER          
SEQRES  29 P  377  GLU ILE GLU GLU THR LYS PRO ALA LYS THR VAL ASN TYR          
SEQRES   1 Q  175  MET ALA ALA VAL SER ILE SER VAL SER LEU ARG GLN ALA          
SEQRES   2 Q  175  MET LEU GLY ARG ARG ALA MET ALA THR ALA ALA VAL SER          
SEQRES   3 Q  175  VAL CYS ARG VAL PRO SER ARG LEU LEU SER THR SER THR          
SEQRES   4 Q  175  TRP LYS LEU ALA ASP ASN GLN THR ARG ASP THR GLN LEU          
SEQRES   5 Q  175  ILE THR VAL ASP GLU LYS LEU ASP ILE THR THR LEU THR          
SEQRES   6 Q  175  GLY VAL PRO GLU GLU HIS ILE LYS THR ARG LYS VAL ARG          
SEQRES   7 Q  175  ILE PHE VAL PRO ALA ARG ASN ASN MET GLN SER GLY VAL          
SEQRES   8 Q  175  ASN ASN THR LYS LYS TRP LYS MET GLU PHE ASP THR ARG          
SEQRES   9 Q  175  GLU ARG TRP GLU ASN PRO LEU MET GLY TRP ALA SER THR          
SEQRES  10 Q  175  ALA ASP PRO LEU SER ASN MET VAL LEU THR PHE SER ALA          
SEQRES  11 Q  175  LYS GLU ASP ALA ILE ALA PHE ALA GLU LYS ASN GLY TRP          
SEQRES  12 Q  175  SER TYR ASP VAL GLU GLU LYS LYS VAL PRO LYS PRO LYS          
SEQRES  13 Q  175  SER LYS SER TYR GLY ALA ASN PHE SER TRP ASN LYS ARG          
SEQRES  14 Q  175  THR ARG VAL SER THR LYS                                      
SEQRES   1 R  116  MET ALA ALA VAL LEU THR PHE ARG ARG LEU LEU THR LEU          
SEQRES   2 R  116  PRO ARG ALA ALA ARG GLY PHE GLY VAL GLN VAL SER PRO          
SEQRES   3 R  116  SER GLY GLU LYS ILE THR HIS THR GLY GLN VAL TYR ASP          
SEQRES   4 R  116  GLU LYS ASP TYR ARG ARG VAL ARG PHE VAL ASP ARG GLN          
SEQRES   5 R  116  LYS GLU VAL ASN GLU ASN PHE ALA ILE ASP LEU ILE ALA          
SEQRES   6 R  116  GLN GLN PRO VAL ASN GLU VAL GLU HIS ARG ILE ILE ALA          
SEQRES   7 R  116  CYS ASP GLY GLY GLY GLY ALA LEU GLY HIS PRO LYS VAL          
SEQRES   8 R  116  TYR ILE ASN LEU ASP LYS GLU THR LYS THR GLY THR CYS          
SEQRES   9 R  116  GLY TYR CYS GLY LEU GLN PHE LYS GLN HIS HIS HIS              
SEQRES   1 S   99  MET ALA ALA ALA ALA ALA SER ARG ALA VAL GLY ALA LYS          
SEQRES   2 S   99  LEU GLY LEU ARG GLU ILE ARG VAL HIS LEU CYS GLN ARG          
SEQRES   3 S   99  SER PRO GLY SER GLN GLY VAL ARG ASP PHE ILE VAL GLN          
SEQRES   4 S   99  ARG TYR VAL GLU LEU LYS LYS ALA HIS PRO ASN LEU PRO          
SEQRES   5 S   99  ILE LEU ILE ARG GLU CYS SER GLU VAL GLN PRO LYS LEU          
SEQRES   6 S   99  TRP ALA ARG TYR ALA PHE GLY GLN GLU LYS THR VAL SER          
SEQRES   7 S   99  LEU ASN ASN LEU SER ALA ASP GLU VAL THR ARG ALA MET          
SEQRES   8 S   99  GLN ASN VAL LEU SER GLY LYS ALA                              
SEQRES   1 T  156  MET ALA SER ARG VAL LEU CYS ALA CYS VAL ARG ARG LEU          
SEQRES   2 T  156  PRO ALA ALA PHE ALA PRO LEU PRO ARG LEU PRO THR LEU          
SEQRES   3 T  156  ALA LEU ALA ARG PRO LEU SER THR THR LEU CYS PRO GLU          
SEQRES   4 T  156  GLY ILE ARG ARG ARG PRO GLY ALA LEU GLN SER ALA LEU          
SEQRES   5 T  156  ALA LEU ALA GLN VAL PRO GLY THR VAL THR HIS LEU CYS          
SEQRES   6 T  156  ARG GLN TYR SER ASP ALA PRO PRO LEU THR LEU ASP GLY          
SEQRES   7 T  156  ILE LYS ASP ARG VAL LEU TYR VAL LEU LYS LEU TYR ASP          
SEQRES   8 T  156  LYS ILE ASP PRO GLU LYS LEU SER VAL ASN SER HIS PHE          
SEQRES   9 T  156  MET LYS ASP LEU GLY LEU ASP SER LEU ASP GLN VAL GLU          
SEQRES  10 T  156  ILE ILE MET ALA MET GLU ASP GLU PHE GLY PHE GLU ILE          
SEQRES  11 T  156  PRO ASP ILE ASP ALA GLU LYS LEU MET CYS PRO GLN GLU          
SEQRES  12 T  156  ILE VAL ASP TYR ILE ALA ASP LYS LYS ASP VAL TYR GLU          
SEQRES   1 U  156  MET ALA SER ARG VAL LEU CYS ALA CYS VAL ARG ARG LEU          
SEQRES   2 U  156  PRO ALA ALA PHE ALA PRO LEU PRO ARG LEU PRO THR LEU          
SEQRES   3 U  156  ALA LEU ALA ARG PRO LEU SER THR THR LEU CYS PRO GLU          
SEQRES   4 U  156  GLY ILE ARG ARG ARG PRO GLY ALA LEU GLN SER ALA LEU          
SEQRES   5 U  156  ALA LEU ALA GLN VAL PRO GLY THR VAL THR HIS LEU CYS          
SEQRES   6 U  156  ARG GLN TYR SER ASP ALA PRO PRO LEU THR LEU ASP GLY          
SEQRES   7 U  156  ILE LYS ASP ARG VAL LEU TYR VAL LEU LYS LEU TYR ASP          
SEQRES   8 U  156  LYS ILE ASP PRO GLU LYS LEU SER VAL ASN SER HIS PHE          
SEQRES   9 U  156  MET LYS ASP LEU GLY LEU ASP SER LEU ASP GLN VAL GLU          
SEQRES  10 U  156  ILE ILE MET ALA MET GLU ASP GLU PHE GLY PHE GLU ILE          
SEQRES  11 U  156  PRO ASP ILE ASP ALA GLU LYS LEU MET CYS PRO GLN GLU          
SEQRES  12 U  156  ILE VAL ASP TYR ILE ALA ASP LYS LYS ASP VAL TYR GLU          
SEQRES   1 V  116  MET ALA GLY LEU LEU LYS LYS THR THR GLY LEU VAL GLY          
SEQRES   2 V  116  LEU ALA VAL CYS ASP THR PRO HIS GLU ARG LEU THR ILE          
SEQRES   3 V  116  LEU TYR THR LYS THR LEU ASP ILE LEU LYS HIS PHE PRO          
SEQRES   4 V  116  LYS HIS ALA ALA TYR ARG LYS TYR THR GLU GLN ILE THR          
SEQRES   5 V  116  ASN GLU LYS LEU ASP MET VAL LYS ALA GLU PRO ASP VAL          
SEQRES   6 V  116  LYS LYS LEU GLU ALA LEU LEU GLN GLY GLY GLU VAL GLU          
SEQRES   7 V  116  GLU VAL ILE LEU GLN ALA GLU LYS GLU LEU SER LEU ALA          
SEQRES   8 V  116  ARG LYS MET LEU LYS TRP LYS PRO TRP GLU PRO LEU VAL          
SEQRES   9 V  116  GLU GLU PRO PRO ALA ASN GLN TRP LYS TRP PRO ILE              
SEQRES   1 W  131  MET ALA ALA ALA ALA THR GLY LEU ARG GLN ALA ALA ALA          
SEQRES   2 W  131  ALA ALA ALA SER THR SER VAL LYS PRO ILE PHE SER ARG          
SEQRES   3 W  131  ASP LEU ASN GLU ALA LYS ARG ARG VAL ARG GLU LEU TYR          
SEQRES   4 W  131  ARG ALA TRP TYR ARG GLU VAL PRO ASN THR VAL HIS LEU          
SEQRES   5 W  131  MET GLN LEU ASP ILE THR VAL LYS GLN GLY ARG ASP LYS          
SEQRES   6 W  131  VAL ARG GLU MET PHE MET LYS ASN ALA HIS VAL THR ASP          
SEQRES   7 W  131  PRO ARG VAL VAL ASP LEU LEU VAL ILE LYS GLY LYS MET          
SEQRES   8 W  131  GLU LEU GLN GLU THR ILE LYS VAL TRP LYS GLN ARG THR          
SEQRES   9 W  131  HIS VAL MET ARG PHE PHE HIS GLU THR GLU THR PRO ARG          
SEQRES  10 W  131  PRO LYS ASP PHE LEU SER LYS PHE TYR MET GLY HIS ASP          
SEQRES  11 W  131  PRO                                                          
SEQRES   1 X  172  MET PRO GLY ILE VAL GLU LEU PRO THR LEU GLU GLU LEU          
SEQRES   2 X  172  LYS VAL GLU GLU VAL LYS VAL SER SER ALA VAL LEU LYS          
SEQRES   3 X  172  ALA ALA ALA HIS HIS TYR GLY ALA GLN CYS ASP LYS THR          
SEQRES   4 X  172  ASN LYS GLU PHE MET LEU CYS ARG TRP GLU GLU LYS ASP          
SEQRES   5 X  172  PRO ARG ARG CYS LEU LYS GLU GLY LYS LEU VAL ASN GLY          
SEQRES   6 X  172  CYS ALA LEU ASN PHE PHE ARG GLN ILE LYS SER HIS CYS          
SEQRES   7 X  172  ALA GLU PRO PHE THR GLU TYR TRP THR CYS LEU ASP TYR          
SEQRES   8 X  172  SER ASN MET GLN LEU PHE ARG HIS CYS ARG GLN GLN GLN          
SEQRES   9 X  172  ALA LYS PHE ASP GLN CYS VAL LEU ASP LYS LEU GLY TRP          
SEQRES  10 X  172  VAL ARG PRO ASP LEU GLY GLN LEU SER LYS VAL THR LYS          
SEQRES  11 X  172  VAL LYS THR ASP ARG PRO LEU PRO GLU ASN PRO TYR HIS          
SEQRES  12 X  172  SER ARG ALA ARG PRO GLU PRO ASN PRO VAL ILE GLU GLY          
SEQRES  13 X  172  ASP LEU LYS PRO ALA LYS HIS GLY THR ARG PHE PHE PHE          
SEQRES  14 X  172  TRP THR VAL                                                  
SEQRES   1 Y  143  MET ALA MET VAL LYS ARG PHE PHE GLU SER TYR HIS GLU          
SEQRES   2 Y  143  VAL PRO ASP GLY THR GLN CYS HIS ARG LYS THR TYR ILE          
SEQRES   3 Y  143  THR THR ALA LEU GLY GLY ILE CYS GLY ILE ILE GLY SER          
SEQRES   4 Y  143  ALA TYR SER VAL SER LEU ASN PRO ALA ASP SER THR LEU          
SEQRES   5 Y  143  GLU ALA VAL ALA ARG VAL GLY ARG TYR THR PHE THR ALA          
SEQRES   6 Y  143  ALA ALA ILE GLY ALA MET PHE GLY LEU THR THR CYS VAL          
SEQRES   7 Y  143  SER ALA GLN VAL ARG GLU LYS PRO ASP ASP PRO LEU ASN          
SEQRES   8 Y  143  TYR PHE ILE GLY GLY CYS ALA GLY GLY LEU THR LEU GLY          
SEQRES   9 Y  143  ALA ARG THR HIS SER TYR GLY THR ALA ALA MET GLY CYS          
SEQRES  10 Y  143  VAL TYR MET GLY THR ALA ALA ALA LEU PHE LYS ILE GLY          
SEQRES  11 Y  143  LYS LEU GLU GLY TRP GLU LEU PHE PRO THR PRO LYS VAL          
SEQRES   1 Z  144  MET ALA ALA SER LYS VAL LYS GLN ASP MET PRO PRO PRO          
SEQRES   2 Z  144  GLY GLY TYR GLY PRO ILE ASP TYR LYS ARG ASN LEU PRO          
SEQRES   3 Z  144  ARG ARG GLY LEU SER GLY TYR SER MET PHE ALA VAL GLY          
SEQRES   4 Z  144  ILE GLY ALA LEU ILE PHE GLY TYR TRP ARG MET MET ARG          
SEQRES   5 Z  144  TRP ASN GLN GLU ARG ARG ARG LEU LEU ILE GLU ASP LEU          
SEQRES   6 Z  144  GLU ALA ARG ILE ALA LEU MET PRO LEU PHE GLN ALA GLU          
SEQRES   7 Z  144  LYS ASP ARG ARG THR LEU GLN ILE LEU ARG GLU ASN LEU          
SEQRES   8 Z  144  GLU GLU GLU ALA ILE ILE MET LYS ASP VAL PRO ASN TRP          
SEQRES   9 Z  144  LYS VAL GLY GLU SER VAL PHE HIS THR THR ARG TRP VAL          
SEQRES  10 Z  144  PRO PRO LEU ILE GLY GLU MET TYR GLY LEU ARG THR LYS          
SEQRES  11 Z  144  GLU GLU MET SER ASN ALA ASN PHE GLY PHE THR TRP TYR          
SEQRES  12 Z  144  THR                                                          
SEQRES   1 a   67  MET TRP PHE GLU ILE LEU PRO GLY LEU ALA ILE MET GLY          
SEQRES   2 a   67  VAL CYS LEU VAL ILE PRO GLY VAL SER THR ALA TYR ILE          
SEQRES   3 a   67  HIS LYS PHE THR ASN GLY GLY LYS GLU LYS ARG VAL ALA          
SEQRES   4 a   67  ARG VAL GLN TYR GLN TRP TYR LEU MET GLU ARG ASP ARG          
SEQRES   5 a   67  ARG ILE SER GLY VAL ASN ARG TYR TYR VAL SER LYS GLY          
SEQRES   6 a   67  LEU GLU                                                      
SEQRES   1 b   84  MET AYA GLY ARG ILE SER ALA PHE LEU LYS ASN ALA TRP          
SEQRES   2 b   84  ALA LYS GLU PRO VAL LEU VAL VAL SER PHE SER VAL TRP          
SEQRES   3 b   84  GLY LEU ALA ILE ILE MET PRO MET ILE SER PRO TYR THR          
SEQRES   4 b   84  LYS TYR ALA SER MET ILE ASN LYS ALA THR PRO TYR ASN          
SEQRES   5 b   84  TYR PRO VAL PRO VAL ARG ASP ASP GLY ASN MET PRO ASP          
SEQRES   6 b   84  VAL PRO SER HIS PRO GLN ASP PRO LEU GLY PRO SER LEU          
SEQRES   7 b   84  ASP TRP LEU LYS ASN LEU                                      
SEQRES   1 c   76  MET ALA PRO SER VAL VAL LEU ARG SER PHE SER ARG LEU          
SEQRES   2 c   76  LEU ALA PRO ALA ARG LEU PRO SER CYS SER SER THR ARG          
SEQRES   3 c   76  SER LYS PHE TYR VAL ARG GLU PRO VAL ASN ALA LYS PRO          
SEQRES   4 c   76  ASN TRP LEU ALA VAL GLY LEU SER VAL GLY ALA SER VAL          
SEQRES   5 c   76  PHE MET TRP ILE TYR LEU ILE GLN THR HIS ASN GLU ASP          
SEQRES   6 c   76  VAL LEU GLU TYR LYS ARG ARG ASN GLY LEU GLU                  
SEQRES   1 d  120  MET MET ASN GLY ARG PRO GLY HIS GLU PRO LEU LYS PHE          
SEQRES   2 d  120  LEU PRO ASP GLU ALA ARG SER LEU PRO PRO PRO LYS LEU          
SEQRES   3 d  120  ASN ASP PRO ARG LEU VAL TYR MET GLY LEU LEU GLY TYR          
SEQRES   4 d  120  CYS THR GLY LEU MET ASP ASN MET LEU ARG MET ARG PRO          
SEQRES   5 d  120  VAL MET ARG ALA GLY LEU HIS ARG GLN LEU LEU PHE VAL          
SEQRES   6 d  120  THR SER PHE VAL PHE ALA GLY TYR PHE TYR LEU LYS ARG          
SEQRES   7 d  120  GLN ASN TYR LEU TYR ALA VAL LYS ASP HIS ASP MET PHE          
SEQRES   8 d  120  GLY TYR ILE LYS LEU HIS PRO GLU ASP PHE PRO GLU LYS          
SEQRES   9 d  120  GLU LYS LYS THR TYR ALA GLU ILE LEU GLU PRO PHE HIS          
SEQRES  10 d  120  PRO VAL ARG                                                  
SEQRES   1 e  106  MET PRO PHE LEU ASP ILE GLN LYS LYS LEU GLY ILE SER          
SEQRES   2 e  106  LEU ASP ARG HIS PHE MET PHE LEU SER ALA GLU GLN PRO          
SEQRES   3 e  106  TYR LYS ASN ALA ALA ARG CYS HIS ALA PHE GLU LYS GLU          
SEQRES   4 e  106  TRP ILE GLU CYS ALA HIS GLY ILE GLY GLY THR ARG ALA          
SEQRES   5 e  106  LYS LYS GLU CYS LYS ILE GLU PHE ASP ASP PHE GLU GLU          
SEQRES   6 e  106  CYS LEU LEU ARG TYR LYS THR MET ARG ARG MET HIS ASP          
SEQRES   7 e  106  ILE LYS LYS GLN ARG GLU LYS LEU MET LYS GLU GLY LYS          
SEQRES   8 e  106  TYR THR PRO PRO PRO HIS HIS SER GLY ARG GLU GLU PRO          
SEQRES   9 e  106  ARG PRO                                                      
SEQRES   1 f   57  MET THR LEU PHE GLN LEU LEU ARG GLU HIS TRP VAL HIS          
SEQRES   2 f   57  ILE LEU VAL PRO ALA GLY PHE VAL PHE GLY CYS TYR LEU          
SEQRES   3 f   57  ASP ARG LYS ASP ASP GLU LYS LEU THR ALA PHE ARG ASN          
SEQRES   4 f   57  LYS SER MET LEU PHE GLN ARG GLU LEU ARG PRO ASN GLU          
SEQRES   5 f   57  GLU VAL THR TRP LYS                                          
SEQRES   1 g  151  MET ALA ALA ARG LEU LEU SER LEU TYR GLY ARG CYS LEU          
SEQRES   2 g  151  SER ALA ALA GLY ALA MET ARG GLY LEU PRO ALA ALA ARG          
SEQRES   3 g  151  VAL ARG TRP GLU SER SER ARG ALA VAL ILE ALA PRO SER          
SEQRES   4 g  151  GLY VAL GLU LYS LYS ARG GLN ARG GLU PRO THR MET GLN          
SEQRES   5 g  151  TRP GLN GLU ASP PRO GLU PRO GLU ASP GLU ASN VAL TYR          
SEQRES   6 g  151  ALA LYS ASN PRO ASP PHE HIS GLY TYR ASP SER ASP PRO          
SEQRES   7 g  151  VAL VAL ASP VAL TRP ASN MET ARG ALA VAL PHE PHE PHE          
SEQRES   8 g  151  GLY PHE SER ILE VAL LEU VAL PHE GLY THR THR PHE VAL          
SEQRES   9 g  151  ALA TYR VAL PRO ASP TYR ARG MET GLN GLU TRP ALA ARG          
SEQRES  10 g  151  ARG GLU ALA GLU ARG LEU VAL LYS TYR ARG GLU VAL ASN          
SEQRES  11 g  151  GLY LEU PRO ILE MET GLU SER ASN TYR PHE ASP PRO SER          
SEQRES  12 g  151  LYS ILE GLN LEU PRO GLU ASP ASP                              
SEQRES   1 h  189  MET ALA ALA MET SER LEU LEU GLN ARG ALA SER VAL SER          
SEQRES   2 h  189  ALA LEU THR ALA LEU SER CYS ARG ARG ALA GLY PRO ARG          
SEQRES   3 h  189  LEU GLY VAL GLY SER PHE LEU THR ARG SER PHE PRO LYS          
SEQRES   4 h  189  THR VAL ALA PRO VAL ARG HIS SER GLY ASP HIS GLY LYS          
SEQRES   5 h  189  ARG LEU PHE VAL VAL LYS PRO SER LEU TYR TYR ASP ALA          
SEQRES   6 h  189  ARG PHE LEU ARG LEU MET LYS PHE TYR LEU MET LEU THR          
SEQRES   7 h  189  GLY ILE PRO VAL ILE ILE GLY ILE THR LEU VAL ASN ILE          
SEQRES   8 h  189  PHE ILE GLY GLU ALA GLU LEU ALA GLU ILE PRO GLU GLY          
SEQRES   9 h  189  TYR ILE PRO GLU HIS TRP GLU TYR TYR LYS HIS PRO ILE          
SEQRES  10 h  189  SER ARG TRP ILE ALA ARG ASN PHE TYR ASP GLY PRO GLU          
SEQRES  11 h  189  LYS ASN TYR GLU LYS THR LEU ALA ILE LEU GLN ILE GLU          
SEQRES  12 h  189  SER GLU LYS ALA GLU LEU ARG LEU LYS GLU GLN GLU VAL          
SEQRES  13 h  189  ARG ARG LEU MET ARG ALA ARG GLY ASP GLY PRO TRP TYR          
SEQRES  14 h  189  GLN PHE PRO THR PRO GLU LYS GLU PHE ILE ASP HIS SER          
SEQRES  15 h  189  PRO LYS ALA THR PRO ASP ASN                                  
SEQRES   1 i  128  MET SAC GLY TYR THR PRO ASP GLU LYS LEU ARG LEU GLN          
SEQRES   2 i  128  GLN LEU ARG GLU LEU ARG ARG ARG TRP LEU LYS ASP GLN          
SEQRES   3 i  128  GLU LEU SER PRO ARG GLU PRO VAL LEU PRO PRO ARG ARG          
SEQRES   4 i  128  MET TRP PRO LEU GLU ARG PHE TRP ASP ASN PHE LEU ARG          
SEQRES   5 i  128  ASP GLY ALA VAL TRP LYS ASN MET VAL PHE LYS ALA TYR          
SEQRES   6 i  128  ARG SER SER LEU PHE ALA VAL SER HIS VAL LEU ILE PRO          
SEQRES   7 i  128  MET TRP PHE VAL HIS TYR TYR VAL LYS TYR HIS MET ALA          
SEQRES   8 i  128  THR LYS PRO TYR THR ILE VAL SER SER LYS PRO ARG ILE          
SEQRES   9 i  128  PHE PRO GLY ASP THR ILE LEU GLU THR GLY GLU VAL ILE          
SEQRES  10 i  128  PRO PRO MET ARG ASP PHE PRO ASP GLN HIS HIS                  
SEQRES   1 j  105  MET SER ALA LEU THR ARG LEU VAL PRO PHE GLY ARG VAL          
SEQRES   2 j  105  GLY GLY ARG LEU LEU ARG GLY CYS ARG ALA ARG ALA ALA          
SEQRES   3 j  105  GLY ASP SER GLY VAL ARG HIS ALA GLY GLY GLY VAL HIS          
SEQRES   4 j  105  ILE GLN PRO ARG TYR ARG GLU PHE PRO GLN LEU THR ARG          
SEQRES   5 j  105  SER GLN VAL ILE GLN GLY GLU PHE LEU SER SER LEU MET          
SEQRES   6 j  105  TRP PHE TRP ILE LEU TRP ARG PHE TRP HIS ASP SER ASP          
SEQRES   7 j  105  ALA VAL LEU GLY HIS PHE SER TYR PRO ASP PRO SER GLN          
SEQRES   8 j  105  TRP THR ASP GLU GLU LEU GLY ILE PRO PRO ASP ASP GLU          
SEQRES   9 j  105  ASP                                                          
SEQRES   1 k  104  MET ALA ALA GLY HIS GLY HIS GLU HIS GLY HIS GLU HIS          
SEQRES   2 k  104  GLY HIS GLY HIS GLY LYS MET GLU LEU PRO ASP TYR ARG          
SEQRES   3 k  104  GLN TRP LYS ILE GLU GLY THR PRO LEU GLU THR VAL GLN          
SEQRES   4 k  104  LYS LYS LEU ALA ALA ARG GLY LEU ARG ASP PRO TRP ALA          
SEQRES   5 k  104  ARG ASN GLU ALA TRP ARG TYR MET GLY GLY PHE ALA GLY          
SEQRES   6 k  104  ASN ILE THR PHE PRO SER VAL ILE LEU LYS GLY PHE LYS          
SEQRES   7 k  104  TRP GLY PHE ALA ALA PHE VAL VAL ALA LEU GLY ALA GLU          
SEQRES   8 k  104  TYR PHE LEU ASP SER GLN ASN GLY ASP LYS LYS HIS HIS          
SEQRES   1 l  186  MET ALA ALA ALA ARG ALA ALA ALA LEU GLY VAL ARG TRP          
SEQRES   2 l  186  LEU GLN ARG THR THR ARG GLY VAL VAL PRO LEU GLU ALA          
SEQRES   3 l  186  ARG ARG ALA PHE HIS MET THR LYS ASP MET LEU PRO GLY          
SEQRES   4 l  186  SER TYR PRO ARG THR PRO GLU GLU ARG ALA ALA ALA ALA          
SEQRES   5 l  186  LYS LYS TYR ASN MET ARG VAL GLU ASP TYR GLU PRO TYR          
SEQRES   6 l  186  PRO ASP ASP GLY MET GLY TYR GLY ASP TYR PRO MET LEU          
SEQRES   7 l  186  PRO ASN ARG SER GLN HIS GLU ARG ASP PRO TRP TYR GLN          
SEQRES   8 l  186  TRP ASP HIS SER GLU LEU ARG MET ASN TRP GLY GLU PRO          
SEQRES   9 l  186  ILE HIS TRP ASP LEU ASP MET TYR ILE ARG ASN ARG VAL          
SEQRES  10 l  186  ASP THR SER PRO THR PRO VAL SER TRP ASP VAL MET CYS          
SEQRES  11 l  186  LYS HIS LEU PHE GLY PHE VAL ALA PHE MET VAL PHE MET          
SEQRES  12 l  186  PHE TRP VAL GLY HIS VAL PHE PRO SER TYR GLN PRO VAL          
SEQRES  13 l  186  GLY PRO LYS GLN TYR PRO TYR ASN ASN LEU TYR LEU GLU          
SEQRES  14 l  186  ARG GLY GLY ASP PRO THR LYS GLU PRO GLU PRO VAL VAL          
SEQRES  15 l  186  HIS TYR ASP ILE                                              
SEQRES   1 m  129  MET SER GLY SER LYS TYR LYS PRO ALA PRO LEU ALA THR          
SEQRES   2 m  129  LEU PRO SER THR LEU ASP PRO ALA GLU TYR ASP VAL SER          
SEQRES   3 m  129  PRO GLU THR ARG ARG ALA GLN VAL GLU ARG LEU SER ILE          
SEQRES   4 m  129  ARG ALA ARG LEU LYS ARG GLU TYR LEU LEU GLN TYR ASN          
SEQRES   5 m  129  ASP PRO LYS ARG VAL SER HIS ILE GLU ASP PRO ALA LEU          
SEQRES   6 m  129  ILE ARG TRP THR TYR ALA ARG SER ALA ASN ILE TYR PRO          
SEQRES   7 m  129  ASN PHE ARG PRO THR PRO LYS ASN SER LEU LEU GLY ALA          
SEQRES   8 m  129  VAL ALA GLY PHE GLY PRO LEU ILE PHE TRP TYR TYR VAL          
SEQRES   9 m  129  PHE LYS THR ASP ARG ASP ARG LYS GLU ARG LEU ILE GLN          
SEQRES  10 m  129  GLU GLY LYS LEU ASP ARG LYS PHE ASN ILE SER TYR              
SEQRES   1 n  179  MET ALA PHE CYS ALA PRO PRO ALA TYR LEU THR HIS GLN          
SEQRES   2 n  179  GLN LYS VAL LEU ARG LEU TYR LYS ARG ALA LEU ARG HIS          
SEQRES   3 n  179  LEU GLU SER TRP CYS ILE HIS ARG ASP LYS TYR ARG TYR          
SEQRES   4 n  179  PHE ALA CYS LEU MET ARG ALA ARG PHE GLU GLU HIS LYS          
SEQRES   5 n  179  ASN GLU LYS ASP MET MET ARG ALA THR GLN LEU LEU ARG          
SEQRES   6 n  179  GLU ALA GLU GLU GLU PHE TRP GLN ASN GLN HIS PRO GLN          
SEQRES   7 n  179  PRO TYR ILE PHE PRO ASP SER PRO GLY GLY THR SER PHE          
SEQRES   8 n  179  GLU ARG TYR GLU CYS TYR LYS VAL PRO GLU TRP CYS LEU          
SEQRES   9 n  179  ASP TYR TRP HIS PRO SER GLU LYS ALA MET TYR PRO ASP          
SEQRES  10 n  179  TYR PHE SER LYS ARG GLU GLN TRP LYS LYS LEU ARG MET          
SEQRES  11 n  179  GLU SER TRP ASP ARG GLU VAL LYS GLN LEU GLN GLU GLU          
SEQRES  12 n  179  THR SER PRO ASP GLY ILE MET THR GLU ALA LEU PRO PRO          
SEQRES  13 n  179  ALA ARG ARG GLU GLY ASP LEU PRO PRO LEU TRP TRP HIS          
SEQRES  14 n  179  ILE VAL THR ARG PRO ARG GLU ARG PRO THR                      
SEQRES   1 o  137  MET GLY ALA HIS LEU THR ARG ARG TYR LEU TRP ASP ALA          
SEQRES   2 o  137  SER VAL GLU PRO ASP PRO GLU LYS ILE PRO SER PHE PRO          
SEQRES   3 o  137  PRO ASP LEU GLY PHE PRO GLU ARG LYS GLU ARG VAL MET          
SEQRES   4 o  137  VAL ALA THR GLN GLN GLU MET MET ASP ALA GLN LEU THR          
SEQRES   5 o  137  LEU GLN GLN ARG ASP TYR CYS ALA HIS TYR LEU ILE ARG          
SEQRES   6 o  137  LEU LEU LYS CYS LYS ARG ASP SER PHE PRO ASN PHE LEU          
SEQRES   7 o  137  ALA CYS LYS HIS GLU GLN HIS ASP TRP ASP TYR CYS GLU          
SEQRES   8 o  137  HIS LEU ASP TYR VAL LYS ARG MET LYS GLU PHE GLU ARG          
SEQRES   9 o  137  GLU ARG ARG LEU LEU GLN ARG LYS LYS ARG ARG ALA LEU          
SEQRES  10 o  137  LYS GLU ALA ARG VAL ALA GLN GLY GLN GLY GLU GLY GLU          
SEQRES  11 o  137  VAL GLY PRO GLU VAL ALA LEU                                  
SEQRES   1 p  176  MET PRO ASP SER TRP ASP LYS ASP VAL TYR PRO GLU PRO          
SEQRES   2 p  176  PRO SER ARG THR PRO ALA PRO SER PRO GLN THR SER LEU          
SEQRES   3 p  176  PRO ASN PRO ILE THR TYR LEU THR LYS ALA TYR ASP LEU          
SEQRES   4 p  176  VAL VAL ASP TRP PRO VAL THR LEU VAL ARG GLU PHE ILE          
SEQRES   5 p  176  GLU ARG GLN HIS ALA LYS ASN ARG THR TYR TYR TYR HIS          
SEQRES   6 p  176  ARG GLN TYR ARG ARG VAL PRO ASP ILE THR GLU CYS LYS          
SEQRES   7 p  176  GLU GLY ASP VAL LEU CYS ILE TYR GLU ALA GLU MET GLN          
SEQRES   8 p  176  TRP ARG ARG ASP PHE LYS VAL ASP GLN GLU ILE MET ASN          
SEQRES   9 p  176  ILE ILE GLN GLU ARG LEU LYS ALA CYS GLN GLN ARG GLU          
SEQRES  10 p  176  GLY GLU ASN TYR GLN GLN ASN CYS ALA LYS GLU LEU GLU          
SEQRES  11 p  176  GLN PHE THR LYS VAL THR LYS ALA TYR GLN ASP ARG TYR          
SEQRES  12 p  176  LEU ASP LEU GLY ALA TYR TYR SER ALA ARG LYS CYS LEU          
SEQRES  13 p  176  ALA LYS GLN LYS GLN ARG MET LEU GLU GLU ARG LYS ALA          
SEQRES  14 p  176  ALA ARG GLN GLU ALA ALA ALA                                  
SEQRES   1 q  145  AME GLU LEU VAL GLU VAL LEU LYS ARG GLY VAL GLN GLN          
SEQRES   2 q  145  VAL THR GLY HIS GLY GLY LEU ARG GLY LEU LEU ARG VAL          
SEQRES   3 q  145  PHE PHE ARG ALA ASN ASP ILE ARG ILE GLY THR LEU VAL          
SEQRES   4 q  145  GLY GLU ASP LYS TYR GLY ASN LYS TYR TYR GLU ASP ASN          
SEQRES   5 q  145  LYS GLN PHE PHE GLY ARG HIS ARG TRP VAL ILE TYR THR          
SEQRES   6 q  145  THR GLU MET ASN GLY LYS ASN THR PHE TRP ASP VAL ASP          
SEQRES   7 q  145  GLY SER MET VAL PRO PRO GLU TRP HIS ARG TRP LEU HIS          
SEQRES   8 q  145  CYS MET THR ASP ASP PRO PRO THR THR ASN PRO PRO THR          
SEQRES   9 q  145  ALA ARG LYS PHE ILE TRP THR ASN HIS LYS PHE ASN VAL          
SEQRES  10 q  145  SER ALA THR PRO GLU GLN TYR VAL PRO TYR SER THR THR          
SEQRES  11 q  145  ARG LYS LYS ILE HIS GLU TRP VAL PRO PRO SER THR PRO          
SEQRES  12 q  145  TYR LYS                                                      
SEQRES   1 r  113  MET AYA SER ALA THR ARG VAL ILE GLN LYS LEU ARG ASN          
SEQRES   2 r  113  TRP ALA SER GLY GLN ASP LEU GLN ALA LYS LEU GLN LEU          
SEQRES   3 r  113  ARG TYR GLN GLU ILE ALA LYS ARG THR GLN PRO PRO PRO          
SEQRES   4 r  113  LYS LEU PRO VAL GLY PRO SER HIS LYS LEU SER ASN ASN          
SEQRES   5 r  113  TYR TYR CYS THR ARG ASP GLY ARG ARG GLU VAL VAL PRO          
SEQRES   6 r  113  PRO SER ILE ILE MET SER SER GLN LYS ALA LEU VAL SER          
SEQRES   7 r  113  GLY LYS ALA ALA GLU SER SER ALA MET ALA ALA THR GLU          
SEQRES   8 r  113  LYS LYS ALA VAL THR PRO ALA PRO PRO MET LYS ARG TRP          
SEQRES   9 r  113  GLU LEU SER LYS ASP GLN PRO TYR LEU                          
SEQRES   1 s  104  MET ALA VAL SER LEU LEU LEU ARG GLY GLY ARG ILE ARG          
SEQRES   2 s  104  ALA LEU LYS ALA VAL LEU LEU GLU ALA ARG VAL PHE PRO          
SEQRES   3 s  104  GLY GLU LEU VAL SER VAL VAL ARG LEU SER THR GLU SER          
SEQRES   4 s  104  GLU LYS SER ALA LYS GLU LYS GLU LEU HIS PRO LYS THR          
SEQRES   5 s  104  GLN SER VAL LEU LYS GLU PRO GLU PRO THR ASP THR THR          
SEQRES   6 s  104  THR TYR LYS ASN LEU GLN HIS HIS ASP TYR ASN THR TYR          
SEQRES   7 s  104  THR PHE LEU ASP LEU ASN LEU ASP LEU SER LYS PHE ARG          
SEQRES   8 s  104  LEU PRO GLN PRO SER SER GLY ARG GLU SER PRO ARG HIS          
HET    FME  A   1      10                                                       
HET    2MR  D  85      13                                                       
HET    FME  H   1      10                                                       
HET    FME  J   1      10                                                       
HET    FME  K   1      10                                                       
HET    FME  L   1      10                                                       
HET    FME  M   1      10                                                       
HET    FME  N   1      10                                                       
HET    AYA  b   1       8                                                       
HET    SAC  i   1       9                                                       
HET    AME  q   1      11                                                       
HET    AYA  r   1       8                                                       
HET    3PE  A 201      41                                                       
HET    SF4  B 201       8                                                       
HET    FES  E 301       4                                                       
HET    FMN  F 501      31                                                       
HET    SF4  F 502       8                                                       
HET    SF4  G 801       8                                                       
HET    SF4  G 802       8                                                       
HET    FES  G 803       4                                                       
HET    3PE  H 401      51                                                       
HET    PC1  H 402      42                                                       
HET    3PE  H 403      51                                                       
HET    PC1  H 404      47                                                       
HET    CDL  H 405      57                                                       
HET    PC1  H 406      35                                                       
HET    SF4  I 201       8                                                       
HET    SF4  I 202       8                                                       
HET    3PE  L 701      51                                                       
HET    CDL  L 702      78                                                       
HET    CDL  L 703      70                                                       
HET    3PE  L 704      42                                                       
HET    3PE  M 501      51                                                       
HET    3PE  M 502      42                                                       
HET    3PE  M 503      51                                                       
HET    3PE  M 504      51                                                       
HET    3PE  M 505      51                                                       
HET    3PE  M 506      31                                                       
HET    CDL  M 507      67                                                       
HET    3PE  N 401      51                                                       
HET    ADP  O 401      27                                                       
HET    PC1  P 401      43                                                       
HET    NDP  P 501      48                                                       
HET     ZN  R 201       1                                                       
HET    EHZ  T 201      34                                                       
HET    EHZ  U 201      35                                                       
HETNAM     FME N-FORMYLMETHIONINE                                               
HETNAM     2MR N3, N4-DIMETHYLARGININE                                          
HETNAM     AYA N-ACETYLALANINE                                                  
HETNAM     SAC N-ACETYL-SERINE                                                  
HETNAM     AME N-ACETYLMETHIONINE                                               
HETNAM     3PE 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE                      
HETNAM     SF4 IRON/SULFUR CLUSTER                                              
HETNAM     FES FE2/S2 (INORGANIC) CLUSTER                                       
HETNAM     FMN FLAVIN MONONUCLEOTIDE                                            
HETNAM     PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE                           
HETNAM     CDL CARDIOLIPIN                                                      
HETNAM     ADP ADENOSINE-5'-DIPHOSPHATE                                         
HETNAM     NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE                  
HETNAM   2 NDP  PHOSPHATE                                                       
HETNAM      ZN ZINC ION                                                         
HETNAM     EHZ ~{S}-[2-[3-[[(2~{R})-3,3-DIMETHYL-2-OXIDANYL-4-                  
HETNAM   2 EHZ  PHOSPHONOOXY-BUTANOYL]AMINO]PROPANOYLAMINO]ETHYL]               
HETNAM   3 EHZ  (3~{S})-3-OXIDANYLTETRADECANETHIOATE                            
HETSYN     3PE 3-SN-PHOSPHATIDYLETHANOLAMINE                                    
HETSYN     FMN RIBOFLAVIN MONOPHOSPHATE                                         
HETSYN     PC1 3-SN-PHOSPHATIDYLCHOLINE                                         
HETSYN     CDL DIPHOSPHATIDYL GLYCEROL; BIS-(1,2-DIACYL-SN-GLYCERO-3-           
HETSYN   2 CDL  PHOSPHO)-1',3'-SN-GLYCEROL                                      
FORMUL   1  FME    7(C6 H11 N O3 S)                                             
FORMUL   4  2MR    C8 H18 N4 O2                                                 
FORMUL  28  AYA    2(C5 H9 N O3)                                                
FORMUL  35  SAC    C5 H9 N O4                                                   
FORMUL  43  AME    C7 H13 N O3 S                                                
FORMUL  46  3PE    12(C41 H82 N O8 P)                                           
FORMUL  47  SF4    6(FE4 S4)                                                    
FORMUL  48  FES    2(FE2 S2)                                                    
FORMUL  49  FMN    C17 H21 N4 O9 P                                              
FORMUL  55  PC1    4(C44 H88 N O8 P)                                            
FORMUL  58  CDL    4(C81 H156 O17 P2 2-)                                        
FORMUL  74  ADP    C10 H15 N5 O10 P2                                            
FORMUL  76  NDP    C21 H30 N7 O17 P3                                            
FORMUL  77   ZN    ZN 2+                                                        
FORMUL  78  EHZ    2(C25 H49 N2 O9 P S)                                         
HELIX    1   1 LEU A    3  PHE A   22  1                                  20    
HELIX    2   2 PHE A   56  LEU A   73  1                                  18    
HELIX    3   3 LEU A   75  ILE A   79  1                                   5    
HELIX    4   4 THR A   86  THR A  107  1                                  22    
HELIX    5   5 TYR B   38  SER B   53  1                                  16    
HELIX    6   6 CYS B   64  ALA B   73  1                                  10    
HELIX    7   7 MET B  106  GLN B  116  1                                  11    
HELIX    8   8 SER B  128  ASN B  131  1                                   4    
HELIX    9   9 ALA B  163  LYS B  176  1                                  14    
HELIX   10  10 VAL C   17  GLU C   31  1                                  15    
HELIX   11  11 ILE C   58  LEU C   64  1                                   7    
HELIX   12  12 ASN C  128  MET C  137  1                                  10    
HELIX   13  13 ILE D    8  GLN D   13  1                                   6    
HELIX   14  14 THR D   87  TYR D   93  1                                   7    
HELIX   15  15 TYR D   96  ASP D  107  1                                  12    
HELIX   16  16 MET D  112  LEU D  126  1                                  15    
HELIX   17  17 PRO D  132  ILE D  161  1                                  30    
HELIX   18  18 THR D  165  VAL D  184  1                                  20    
HELIX   19  19 LEU D  208  LEU D  229  1                                  22    
HELIX   20  20 ARG D  233  ARG D  238  1                                   6    
HELIX   21  21 ASP D  249  TYR D  253  1                                   5    
HELIX   22  22 TYR D  294  LEU D  315  1                                  22    
HELIX   23  23 MET D  342  GLU D  354  1                                  13    
HELIX   24  24 PRO D  394  SER D  406  1                                  13    
HELIX   25  25 ALA D  412  GLY D  419  1                                   8    
HELIX   26  26 GLU E   26  ASN E   37  1                                  12    
HELIX   27  27 ALA E   46  GLN E   57  1                                  12    
HELIX   28  28 ILE E   63  VAL E   72  1                                  10    
HELIX   29  29 PRO E   77  PHE E   86  1                                  10    
HELIX   30  30 THR E  106  LEU E  110  1                                   5    
HELIX   31  31 SER E  113  LEU E  124  1                                  12    
HELIX   32  32 LYS E  167  ALA E  178  1                                  12    
HELIX   33  33 GLY F   35  ARG F   39  1                                   5    
HELIX   34  34 THR F   45  LEU F   49  1                                   5    
HELIX   35  35 PRO F   53  SER F   63  1                                  11    
HELIX   36  36 THR F   75  SER F   80  1                                   6    
HELIX   37  37 LYS F  106  ARG F  112  1                                   7    
HELIX   38  38 HIS F  116  MET F  129  1                                  14    
HELIX   39  39 ASN F  144  ALA F  159  1                                  16    
HELIX   40  40 GLU F  189  GLU F  197  1                                   9    
HELIX   41  41 VAL F  225  ARG F  237  1                                  13    
HELIX   42  42 THR F  240  PHE F  245  1                                   6    
HELIX   43  43 LEU F  276  GLU F  281  1                                   6    
HELIX   44  44 PHE F  319  ALA F  325  1                                   7    
HELIX   45  45 ILE F  343  GLU F  357  1                                  15    
HELIX   46  46 CYS F  365  PHE F  379  1                                  15    
HELIX   47  47 ALA F  387  GLU F  400  1                                  14    
HELIX   48  48 LEU F  407  ILE F  419  1                                  13    
HELIX   49  49 ARG F  423  GLN F  435  1                                  13    
HELIX   50  50 VAL G   26  VAL G   33  1                                   8    
HELIX   51  51 GLU G   84  ALA G   99  1                                  16    
HELIX   52  52 ASP G  115  MET G  122  1                                   8    
HELIX   53  53 THR G  157  GLU G  165  1                                   9    
HELIX   54  54 LEU G  195  ILE G  202  1                                   8    
HELIX   55  55 ASP G  265  PHE G  269  1                                   5    
HELIX   56  56 TYR G  271  ARG G  276  1                                   6    
HELIX   57  57 ASP G  298  ASN G  309  1                                  12    
HELIX   58  58 ASP G  324  ASN G  336  1                                  13    
HELIX   59  59 LEU G  390  TRP G  399  1                                  10    
HELIX   60  60 LYS G  427  ALA G  433  1                                   7    
HELIX   61  61 PHE G  439  LYS G  444  1                                   6    
HELIX   62  62 SER G  455  GLN G  459  1                                   5    
HELIX   63  63 GLY G  463  VAL G  479  1                                  17    
HELIX   64  64 GLN G  499  LEU G  505  1                                   7    
HELIX   65  65 GLU G  512  LYS G  516  1                                   5    
HELIX   66  66 ASP G  551  MET G  556  1                                   6    
HELIX   67  67 ASP G  596  ILE G  606  1                                  11    
HELIX   68  68 LEU G  616  VAL G  626  1                                  11    
HELIX   69  69 PHE G  642  LEU G  651  1                                  10    
HELIX   70  70 SER G  676  ALA G  680  1                                   5    
HELIX   71  71 GLN G  682  THR G  692  1                                  11    
HELIX   72  72 PHE H    3  MET H   31  1                                  29    
HELIX   73  73 GLN H   47  MET H   57  1                                  11    
HELIX   74  74 MET H   68  VAL H   87  1                                  20    
HELIX   75  75 ILE H  102  ALA H  122  1                                  21    
HELIX   76  76 LYS H  126  MET H  156  1                                  31    
HELIX   77  77 LEU H  162  THR H  168  1                                   7    
HELIX   78  78 TRP H  179  ALA H  191  1                                  13    
HELIX   79  79 GLY H  218  ILE H  241  1                                  24    
HELIX   80  80 PRO H  252  ARG H  274  1                                  23    
HELIX   81  81 TYR H  282  PHE H  310  1                                  29    
HELIX   82  82 LYS I   17  ILE I   26  1                                  10    
HELIX   83  83 GLU I   31  TYR I   42  1                                  12    
HELIX   84  84 LEU I   84  ILE I   88  1                                   5    
HELIX   85  85 PHE I  123  ALA I  127  1                                   5    
HELIX   86  86 GLU I  154  LYS I  162  1                                   9    
HELIX   87  87 ALA I  165  ASP I  174  1                                  10    
HELIX   88  88 TYR J    4  ALA J   20  1                                  17    
HELIX   89  89 ILE J   26  PHE J   46  1                                  21    
HELIX   90  90 SER J   49  ALA J   72  1                                  24    
HELIX   91  91 TRP J   86  TYR J  108  1                                  23    
HELIX   92  92 GLY J  138  ALA J  143  1                                   6    
HELIX   93  93 TRP J  150  ILE J  169  1                                  20    
HELIX   94  94 THR K    4  THR K   19  1                                  16    
HELIX   95  95 MET K   27  SER K   51  1                                  25    
HELIX   96  96 MET K   57  THR K   84  1                                  28    
HELIX   97  97 ILE L    3  SER L   22  1                                  20    
HELIX   98  98 PHE L   32  PHE L   54  1                                  23    
HELIX   99  99 PHE L   85  SER L  105  1                                  21    
HELIX  100 100 ASN L  115  THR L  132  1                                  18    
HELIX  101 101 MET L  137  ILE L  155  1                                  19    
HELIX  102 102 ALA L  164  LEU L  191  1                                  28    
HELIX  103 103 GLN L  199  PHE L  203  1                                   5    
HELIX  104 104 ILE L  211  GLY L  222  1                                  12    
HELIX  105 105 TRP L  232  ALA L  236  1                                   5    
HELIX  106 106 PRO L  242  ARG L  262  1                                  21    
HELIX  107 107 HIS L  264  THR L  268  1                                   5    
HELIX  108 108 PHE L  272  ALA L  292  1                                  21    
HELIX  109 109 ILE L  298  GLY L  318  1                                  21    
HELIX  110 110 PRO L  322  SER L  349  1                                  28    
HELIX  111 111 PRO L  367  LEU L  380  1                                  14    
HELIX  112 112 PHE L  389  ASN L  400  1                                  12    
HELIX  113 113 ALA L  406  VAL L  430  1                                  25    
HELIX  114 114 LEU L  450  ASN L  471  1                                  22    
HELIX  115 115 THR L  489  MET L  509  1                                  21    
HELIX  116 116 PRO L  518  THR L  524  1                                   7    
HELIX  117 117 PHE L  528  THR L  578  1                                  51    
HELIX  118 118 ILE L  584  ILE L  604  1                                  21    
HELIX  119 119 LEU M    2  LEU M   17  1                                  16    
HELIX  120 120 TRP M   24  THR M   40  1                                  17    
HELIX  121 121 LEU M   65  SER M   80  1                                  16    
HELIX  122 122 ASN M   89  SER M  111  1                                  23    
HELIX  123 123 ILE M  116  ARG M  135  1                                  20    
HELIX  124 124 ARG M  142  HIS M  170  1                                  29    
HELIX  125 125 MET M  177  THR M  182  1                                   6    
HELIX  126 126 TRP M  190  ILE M  205  1                                  16    
HELIX  127 127 TRP M  215  VAL M  221  1                                   7    
HELIX  128 128 ALA M  226  ILE M  246  1                                  21    
HELIX  129 129 ASP M  251  TYR M  256  1                                   6    
HELIX  130 130 ALA M  258  LEU M  277  1                                  20    
HELIX  131 131 LEU M  282  ILE M  301  1                                  20    
HELIX  132 132 PRO M  306  ARG M  336  1                                  31    
HELIX  133 133 MET M  355  ASN M  366  1                                  12    
HELIX  134 134 ASN M  374  TRP M  388  1                                  15    
HELIX  135 135 THR M  392  GLN M  415  1                                  24    
HELIX  136 136 ARG M  432  THR M  449  1                                  18    
HELIX  137 137 ILE N    4  MET N   21  1                                  18    
HELIX  138 138 LEU N   26  LEU N   44  1                                  19    
HELIX  139 139 ARG N   51  LYS N   79  1                                  29    
HELIX  140 140 GLY N   92  LEU N  106  1                                  15    
HELIX  141 141 HIS N  112  THR N  119  1                                   8    
HELIX  142 142 HIS N  125  GLN N  144  1                                  20    
HELIX  143 143 THR N  152  GLY N  169  1                                  18    
HELIX  144 144 MET N  175  ILE N  193  1                                  19    
HELIX  145 145 SER N  199  MET N  220  1                                  22    
HELIX  146 146 ILE N  227  SER N  231  1                                   5    
HELIX  147 147 MET N  240  LEU N  251  1                                  12    
HELIX  148 148 GLY N  259  LYS N  272  1                                  14    
HELIX  149 149 ALA N  279  SER N  299  1                                  21    
HELIX  150 150 ASN N  323  ILE N  331  1                                   9    
HELIX  151 151 LEU N  337  ALA N  340  1                                   4    
HELIX  152 152 LYS O   35  GLN O   45  1                                  11    
HELIX  153 153 GLN O   57  THR O   63  1                                   7    
HELIX  154 154 LEU O   79  TYR O   83  1                                   5    
HELIX  155 155 TYR O   94  LEU O  115  1                                  22    
HELIX  156 156 SER O  130  ASN O  140  1                                  11    
HELIX  157 157 LYS O  146  GLU O  162  1                                  17    
HELIX  158 158 VAL O  176  LYS O  185  1                                  10    
HELIX  159 159 SER O  196  SER O  215  1                                  20    
HELIX  160 160 ASP O  224  ASP O  224  1                                   1    
HELIX  161 161 LYS O  233  GLU O  239  1                                   7    
HELIX  162 162 TRP O  254  GLN O  264  1                                  11    
HELIX  163 163 THR O  267  ASN O  271  1                                   5    
HELIX  164 164 HIS O  287  GLU O  298  1                                  12    
HELIX  165 165 LEU P   30  MET P   41  1                                  12    
HELIX  166 166 ILE P   56  LEU P   61  1                                   6    
HELIX  167 167 LYS P   78  GLN P   86  1                                   9    
HELIX  168 168 PHE P  106  ALA P  124  1                                  19    
HELIX  169 169 SER P  145  VAL P  159  1                                  15    
HELIX  170 170 ARG P  177  TYR P  185  1                                   9    
HELIX  171 171 VAL P  207  THR P  218  1                                  12    
HELIX  172 172 LEU P  238  THR P  249  1                                  12    
HELIX  173 173 VAL P  262  PHE P  270  1                                   9    
HELIX  174 174 LYS P  281  HIS P  288  1                                   8    
HELIX  175 175 GLU P  311  ARG P  320  1                                  10    
HELIX  176 176 GLU Q   27  THR Q   32  1                                   6    
HELIX  177 177 LYS Q   89  ASN Q   99  1                                  11    
HELIX  178 178 ALA R   40  GLN R   46  1                                   7    
HELIX  179 179 GLY S   31  VAL S   37  1                                   7    
HELIX  180 180 ARG S   39  ALA S   46  1                                   8    
HELIX  181 181 ALA S   83  LEU S   94  1                                  12    
HELIX  182 182 ASP T    9  LEU T   21  1                                  13    
HELIX  183 183 SER T   44  PHE T   58  1                                  15    
HELIX  184 184 ASP T   66  LEU T   70  1                                   5    
HELIX  185 185 PRO T   73  ASP T   82  1                                  10    
HELIX  186 186 ASP U    9  LEU U   21  1                                  13    
HELIX  187 187 SER U   44  PHE U   58  1                                  15    
HELIX  188 188 GLU U   68  LEU U   70  1                                   3    
HELIX  189 189 PRO U   73  ASP U   82  1                                  10    
HELIX  190 190 HIS V   20  LEU V   34  1                                  15    
HELIX  191 191 ALA V   42  ALA V   60  1                                  19    
HELIX  192 192 VAL V   64  ALA V   69  1                                   6    
HELIX  193 193 GLU V   77  LYS V   95  1                                  19    
HELIX  194 194 ASN W   28  ASN W   47  1                                  20    
HELIX  195 195 VAL W   58  ASN W   72  1                                  15    
HELIX  196 196 PRO W   78  ILE W   96  1                                  19    
HELIX  197 197 ALA X   22  GLY X   32  1                                  11    
HELIX  198 198 ASP X   36  GLU X   48  1                                  13    
HELIX  199 199 LEU X   56  LYS X   74  1                                  19    
HELIX  200 200 ALA X   78  THR X   86  1                                   9    
HELIX  201 201 GLN X  101  LYS X  113  1                                  13    
HELIX  202 202 LYS Y    2  SER Y    7  1                                   6    
HELIX  203 203 CYS Y   17  SER Y   41  1                                  25    
HELIX  204 204 THR Y   48  VAL Y   79  1                                  32    
HELIX  205 205 PRO Y   86  ARG Y  103  1                                  18    
HELIX  206 206 GLY Y  108  LEU Y  129  1                                  22    
HELIX  207 207 GLY Z   31  ILE Z   95  1                                  65    
HELIX  208 208 LYS Z  129  ASN Z  136  1                                   8    
HELIX  209 209 PHE a    3  THR a   30  1                                  28    
HELIX  210 210 GLN a   42  ARG a   53  1                                  12    
HELIX  211 211 ARG b    3  ALA b   13  1                                  11    
HELIX  212 212 LEU b   18  ILE b   34  1                                  17    
HELIX  213 213 ALA b   41  ALA b   47  1                                   7    
HELIX  214 214 LEU c   15  ASN c   46  1                                  32    
HELIX  215 215 ASP d   28  LEU d   48  1                                  21    
HELIX  216 216 ARG d   60  HIS d   97  1                                  38    
HELIX  217 217 HIS e   33  ALA e   43  1                                  11    
HELIX  218 218 LYS e   56  LEU e   66  1                                  11    
HELIX  219 219 TYR e   69  LYS e   84  1                                  16    
HELIX  220 220 HIS f   12  LEU f   33  1                                  22    
HELIX  221 221 PRO g   49  TYR g   77  1                                  29    
HELIX  222 222 GLN g   84  GLU g   99  1                                  16    
HELIX  223 223 TYR h   16  ILE h   45  1                                  30    
HELIX  224 224 PRO h   70  PHE h   79  1                                  10    
HELIX  225 225 PRO h   83  ARG h  117  1                                  35    
HELIX  226 226 ASP i    6  LEU i   22  1                                  17    
HELIX  227 227 ALA i   63  HIS i   88  1                                  26    
HELIX  228 228 SER j   20  ASP j   43  1                                  24    
HELIX  229 229 PHE k   68  LEU k   73  1                                   6    
HELIX  230 230 LYS k   77  ALA k   89  1                                  13    
HELIX  231 231 GLU l   17  LYS l   25  1                                   9    
HELIX  232 232 VAL l   99  VAL l  120  1                                  22    
HELIX  233 233 GLU m   27  GLN m   49  1                                  23    
HELIX  234 234 PRO m   62  SER m   72  1                                  11    
HELIX  235 235 ASN m   74  ASN m   78  1                                   5    
HELIX  236 236 LYS m   84  GLU m  117  1                                  34    
HELIX  237 237 HIS n   11  TRP n   29  1                                  19    
HELIX  238 238 ASP n   34  GLU n   49  1                                  16    
HELIX  239 239 ARG n   58  GLN n   72  1                                  15    
HELIX  240 240 PHE n  118  GLU n  141  1                                  24    
HELIX  241 241 ALA o   59  SER o   72  1                                  14    
HELIX  242 242 HIS o   81  ALA o  115  1                                  35    
HELIX  243 243 ILE p   29  ASN p   58  1                                  30    
HELIX  244 244 LEU p   82  GLU p  116  1                                  35    
HELIX  245 245 LYS p  126  ASP p  140  1                                  15    
HELIX  246 246 ARG p  152  ALA p  168  1                                  17    
HELIX  247 247 LEU q    3  THR q   15  1                                  13    
HELIX  248 248 ARG q   21  ARG q   29  1                                   9    
HELIX  249 249 GLU q   85  TRP q   89  1                                   5    
HELIX  250 250 GLN r    8  SER r   15  1                                   8    
HELIX  251 251 THR s   44  SER s   53  1                                  10    
SHEET    1   1 1 ASP B  94  VAL B  98  0                                        
SHEET    1   2 1 ARG B 121  MET B 126  0                                        
SHEET    1   3 1 ASP B 153  VAL B 156  0                                        
SHEET    1   4 1 GLN C  38  VAL C  42  0                                        
SHEET    1   5 1 GLU C  47  ILE C  52  0                                        
SHEET    1   6 1 LEU C  75  THR C  79  0                                        
SHEET    1   7 1 ILE C  92  LEU C  97  0                                        
SHEET    1   8 1 ARG C 104  THR C 109  0                                        
SHEET    1   9 1 LEU C 174  ASP C 178  0                                        
SHEET    1  10 1 VAL C 183  PRO C 187  0                                        
SHEET    1  11 1 MET D  47  PHE D  51  0                                        
SHEET    1  12 1 VAL D  65  LEU D  68  0                                        
SHEET    1  13 1 VAL D  73  ASP D  77  0                                        
SHEET    1  14 1 PRO D 360  ILE D 367  0                                        
SHEET    1  15 1 PHE D 374  ASP D 381  0                                        
SHEET    1  16 1 ARG D 388  LYS D 392  0                                        
SHEET    1  17 1 TYR E  98  CYS E 103  0                                        
SHEET    1  18 1 PHE E 137  VAL E 142  0                                        
SHEET    1  19 1 MET E 153  ILE E 156  0                                        
SHEET    1  20 1 ASN E 159  GLU E 162  0                                        
SHEET    1  21 1 TYR F  92  ASN F  96  0                                        
SHEET    1  22 1 ALA F 133  ILE F 138  0                                        
SHEET    1  23 1 ASP F 174  ARG F 179  0                                        
SHEET    1  24 1 THR F 220  ALA F 223  0                                        
SHEET    1  25 1 PHE F 256  GLY F 260  0                                        
SHEET    1  26 1 PRO F 265  VAL F 268  0                                        
SHEET    1  27 1 LEU F 295  PRO F 299  0                                        
SHEET    1  28 1 ALA F 333  MET F 337  0                                        
SHEET    1  29 1 ILE G   9  VAL G  13  0                                        
SHEET    1  30 1 GLN G  16  VAL G  20  0                                        
SHEET    1  31 1 GLY G  76  ILE G  79  0                                        
SHEET    1  32 1 ASP G 139  ILE G 142  0                                        
SHEET    1  33 1 VAL G 146  ILE G 149  0                                        
SHEET    1  34 1 ALA G 207  SER G 210  0                                        
SHEET    1  35 1 ARG G 223  SER G 227  0                                        
SHEET    1  36 1 ILE G 238  THR G 242  0                                        
SHEET    1  37 1 MET G 248  LEU G 251  0                                        
SHEET    1  38 1 MET G 283  ARG G 285  0                                        
SHEET    1  39 1 LEU G 290  TYR G 293  0                                        
SHEET    1  40 1 VAL G 315  ALA G 319  0                                        
SHEET    1  41 1 ASN G 342  THR G 345  0                                        
SHEET    1  42 1 VAL G 376  VAL G 380  0                                        
SHEET    1  43 1 LYS G 405  ILE G 409  0                                        
SHEET    1  44 1 HIS G 421  GLY G 423  0                                        
SHEET    1  45 1 PRO G 449  LEU G 453  0                                        
SHEET    1  46 1 VAL G 489  ILE G 492  0                                        
SHEET    1  47 1 LEU G 522  GLY G 526  0                                        
SHEET    1  48 1 PHE G 542  GLN G 546  0                                        
SHEET    1  49 1 ASP G 558  LEU G 561  0                                        
SHEET    1  50 1 ALA G 571  ASN G 575  0                                        
SHEET    1  51 1 ARG G 579  THR G 583  0                                        
SHEET    1  52 1 ALA I  68  ARG I  71  0                                        
SHEET    1  53 1 ALA I  93  ALA I  98  0                                        
SHEET    1  54 1 THR I 109  ASP I 114  0                                        
SHEET    1  55 1 ALA I 132  VAL I 134  0                                        
SHEET    1  56 1 LEU I 149  ASN I 152  0                                        
SHEET    1  57 1 TYR L  61  THR L  65  0                                        
SHEET    1  58 1 MET L  78  THR L  82  0                                        
SHEET    1  59 1 TYR M  49  PHE M  52  0                                        
SHEET    1  60 1 SER M  57  PRO M  60  0                                        
SHEET    1  61 1 VAL O  24  ASN O  30  0                                        
SHEET    1  62 1 LYS O  49  PRO O  52  0                                        
SHEET    1  63 1 VAL O 122  ARG O 126  0                                        
SHEET    1  64 1 VAL O 169  VAL O 174  0                                        
SHEET    1  65 1 GLU O 219  TYR O 223  0                                        
SHEET    1  66 1 VAL P  20  PHE P  24  0                                        
SHEET    1  67 1 GLN P  44  TYR P  49  0                                        
SHEET    1  68 1 GLN P  67  LEU P  71  0                                        
SHEET    1  69 1 ASN P  89  LEU P  94  0                                        
SHEET    1  70 1 GLU P 127  SER P 133  0                                        
SHEET    1  71 1 ALA P 163  PRO P 168  0                                        
SHEET    1  72 1 LYS P 226  PHE P 230  0                                        
SHEET    1  73 1 LYS Q  34  PHE Q  38  0                                        
SHEET    1  74 1 LYS Q  56  PHE Q  59  0                                        
SHEET    1  75 1 MET Q  82  THR Q  85  0                                        
SHEET    1  76 1 SER Q 102  GLU Q 106  0                                        
SHEET    1  77 1 ASN R  50  VAL R  52  0                                        
SHEET    1  78 1 ILE R  56  ASP R  60  0                                        
SHEET    1  79 1 LYS R  70  ASN R  74  0                                        
SHEET    1  80 1 THR R  81  THR R  83  0                                        
SHEET    1  81 1 GLN R  90  LYS R  92  0                                        
SHEET    1  82 1 GLU S  17  HIS S  21  0                                        
SHEET    1  83 1 ILE S  52  ARG S  55  0                                        
SHEET    1  84 1 LYS S  63  ARG S  67  0                                        
SHEET    1  85 1 GLU S  73  SER S  77  0                                        
SHEET    1  86 1 ILE i  96  SER i  98  0                                        
SHEET    1  87 1 VAL q  39  GLU q  41  0                                        
SHEET    1  88 1 ASN q  46  TYR q  49  0                                        
SHEET    1  89 1 TRP q  61  TYR q  64  0                                        
SHEET    1  90 1 SER r  66  ILE r  68  0                                        
SSBOND   1 CYS X   35    CYS X   65                          1555   1555  2.03  
SSBOND   2 CYS X   45    CYS X   55                          1555   1555  2.03  
SSBOND   3 CYS X   77    CYS X  109                          1555   1555  2.04  
SSBOND   4 CYS X   87    CYS X   99                          1555   1555  2.03  
SSBOND   5 CYS Y   17    CYS Y   74                          1555   1555  2.03  
SSBOND   6 CYS e   32    CYS e   65                          1555   1555  2.04  
SSBOND   7 CYS e   42    CYS e   55                          1555   1555  2.05  
SSBOND   8 CYS o   58    CYS o   89                          1555   1555  2.03  
SSBOND   9 CYS o   68    CYS o   79                          1555   1555  2.03  
SSBOND  10 CYS p   76    CYS p   83                          1555   1555  2.05  
SSBOND  11 CYS p  112    CYS p  124                          1555   1555  2.04  
LINK         C   FME A   1                 N   ASN A   2     1555   1555  1.33  
LINK         SG  CYS B  64                FE3  SF4 B 201     1555   1555  2.34  
LINK         SG  CYS B  65                FE2  SF4 B 201     1555   1555  2.43  
LINK         SG  CYS B 129                FE1  SF4 B 201     1555   1555  2.24  
LINK         O   CYS B 159                FE2  SF4 B 201     1555   1555  2.69  
LINK         SG  CYS B 159                FE4  SF4 B 201     1555   1555  2.25  
LINK         C   HIS D  84                 N   2MR D  85     1555   1555  1.33  
LINK         C   2MR D  85                 N   GLY D  86     1555   1555  1.33  
LINK         SG  CYS E 103                FE1  FES E 301     1555   1555  2.21  
LINK         SG  CYS E 108                FE1  FES E 301     1555   1555  2.24  
LINK         SG  CYS E 144                FE2  FES E 301     1555   1555  2.29  
LINK         SG  CYS E 148                FE2  FES E 301     1555   1555  2.26  
LINK         SG  CYS F 359                FE4  SF4 F 502     1555   1555  2.26  
LINK         SG  CYS F 362                FE1  SF4 F 502     1555   1555  2.25  
LINK         SG  CYS F 365                FE2  SF4 F 502     1555   1555  2.21  
LINK         SG  CYS F 405                FE3  SF4 F 502     1555   1555  2.25  
LINK         SG  CYS G  41                FE1  FES G 803     1555   1555  2.22  
LINK         SG  CYS G  52                FE1  FES G 803     1555   1555  2.25  
LINK         SG  CYS G  55                FE2  FES G 803     1555   1555  2.22  
LINK         SG  CYS G  69                FE2  FES G 803     1555   1555  2.23  
LINK         NE2 HIS G 101                FE3  SF4 G 801     1555   1555  2.15  
LINK         SG  CYS G 105                FE2  SF4 G 801     1555   1555  2.29  
LINK         SG  CYS G 108                FE4  SF4 G 801     1555   1555  2.20  
LINK         SG  CYS G 114                FE1  SF4 G 801     1555   1555  2.27  
LINK         SG  CYS G 153                FE2  SF4 G 802     1555   1555  2.28  
LINK         SG  CYS G 156                FE1  SF4 G 802     1555   1555  2.27  
LINK         SG  CYS G 159                FE3  SF4 G 802     1555   1555  2.28  
LINK         SG  CYS G 203                FE4  SF4 G 802     1555   1555  2.25  
LINK         C   FME H   1                 N   PHE H   2     1555   1555  1.33  
LINK         SG  CYS I  79                FE3  SF4 I 202     1555   1555  2.27  
LINK         SG  CYS I  82                FE4  SF4 I 202     1555   1555  2.26  
LINK         SG  CYS I  85                FE2  SF4 I 202     1555   1555  2.28  
LINK         SG  CYS I  89                FE4  SF4 I 201     1555   1555  2.28  
LINK         SG  CYS I 118                FE2  SF4 I 201     1555   1555  2.32  
LINK         SG  CYS I 121                FE1  SF4 I 201     1555   1555  2.25  
LINK         SG  CYS I 124                FE3  SF4 I 201     1555   1555  2.28  
LINK         SG  CYS I 128                FE1  SF4 I 202     1555   1555  2.27  
LINK         C   FME J   1                 N   ASN J   2     1555   1555  1.33  
LINK         C   FME K   1                 N   PRO K   2     1555   1555  1.35  
LINK         C   FME L   1                 N   ASN L   2     1555   1555  1.33  
LINK         C   FME M   1                 N   LEU M   2     1555   1555  1.33  
LINK         C   FME N   1                 N   ASN N   2     1555   1555  1.34  
LINK         SG  CYS R  59                ZN    ZN R 201     1555   1555  2.33  
LINK         NE2 HIS R  68                ZN    ZN R 201     1555   1555  2.01  
LINK         SG  CYS R  84                ZN    ZN R 201     1555   1555  2.30  
LINK         SG  CYS R  87                ZN    ZN R 201     1555   1555  2.48  
LINK         OG  SER T  44                 P1  EHZ T 201     1555   1555  1.60  
LINK         OG  SER U  44                 P1  EHZ U 201     1555   1555  1.57  
LINK         C   AYA b   1                 N   GLY b   2     1555   1555  1.33  
LINK         C   SAC i   1                 N   GLY i   2     1555   1555  1.33  
LINK         C   AME q   1                 N   GLU q   2     1555   1555  1.34  
LINK         C   AYA r   1                 N   SER r   2     1555   1555  1.33  
SITE     1 AC1  7 ALA J  20  LEU J  21  PHE J  91  LEU K  17                    
SITE     2 AC1  7 MET K  21  PHE K  22  ARG K  23                               
SITE     1 AC2  9 ALA B  63  CYS B  64  CYS B  65  SER B 128                    
SITE     2 AC2  9 CYS B 129  CYS B 159  PRO B 160  ARG D 105                    
SITE     3 AC2  9 HIS D 190                                                     
SITE     1 AC3  8 CYS E 103  THR E 105  PRO E 107  CYS E 108                    
SITE     2 AC3  8 CYS E 144  LEU E 145  CYS E 148  PRO F 102                    
SITE     1 AC4 14 GLY F  67  ARG F  68  GLY F  69  LYS F  78                    
SITE     2 AC4 14 ASN F  96  ASP F  98  GLU F  99  TYR F 184                    
SITE     3 AC4 14 ILE F 185  GLY F 187  ASN F 224  THR F 227                    
SITE     4 AC4 14 ALA F 406  LEU F 407                                          
SITE     1 AC5  7 ILE F 185  PRO F 203  CYS F 359  GLN F 361                    
SITE     2 AC5  7 CYS F 362  CYS F 365  CYS F 405                               
SITE     1 AC6  7 HIS G 101  CYS G 105  CYS G 108  GLN G 110                    
SITE     2 AC6  7 CYS G 114  GLN G 117  GLY G 206                               
SITE     1 AC7  7 CYS G 153  ILE G 154  GLN G 155  CYS G 156                    
SITE     2 AC7  7 THR G 157  CYS G 159  CYS G 203                               
SITE     1 AC8  7 ARG G  39  CYS G  41  GLY G  50  CYS G  52                    
SITE     2 AC8  7 ARG G  53  CYS G  55  CYS G  69                               
SITE     1 AC9 19 TYR A   4  ILE A   7  PHE A   8  ILE A  11                    
SITE     2 AC9 19 THR H  76  LEU H  81  LEU H  98  ASN H  99                    
SITE     3 AC9 19 PHE H 104  THR H 108  PC1 H 402  PHE J  37                    
SITE     4 AC9 19 LEU J  41  LEU J  44  PHE J  56  PHE Z 139                    
SITE     5 AC9 19 THR Z 140  TRP Z 141  ALA a  39                               
SITE     1 AD1  9 SER H  67  MET H  68  SER H  69  ILE H  73                    
SITE     2 AD1  9 3PE H 401  LEU J  30  TRP J  82  GLY J  83                    
SITE     3 AD1  9 ARG P 251                                                     
SITE     1 AD2 14 ARG D 233  TRP H 179  ALA H 182  PHE H 186                    
SITE     2 AD2 14 ILE H 273  LEU H 288  ASN H 292  PHE H 293                    
SITE     3 AD2 14 LEU H 296  TRP H 303  LEU I  27  TRP I  29                    
SITE     4 AD2 14 LEU I  32  ILE Z  39                                          
SITE     1 AD3 12 MET H 183  ASP I  21  THR I  30  ILE I  33                    
SITE     2 AD3 12 ARG I  34  GLY I  37  ARG Z  27  GLY Z  28                    
SITE     3 AD3 12 LEU Z  29  SER Z  30  MET Z  34  TRP r  13                    
SITE     1 AD4 14 TYR H  43  MET a   1  TRP a   2  PHE a   3                    
SITE     2 AD4 14 LEU a   6  LEU q   3  VAL q   6  ARG q   9                    
SITE     3 AD4 14 GLY q  10  GLN q  13  SER r   2  THR r   4                    
SITE     4 AD4 14 VAL r   6  ILE r   7                                          
SITE     1 AD5 10 ASP B  45  LEU B  46  TRP B  49  ARG B  52                    
SITE     2 AD5 10 ILE H  39  VAL H  40  LEU H  46  ARG q  29                    
SITE     3 AD5 10 ASN q  31  TRP q  75                                          
SITE     1 AD6  9 HIS I  67  CYS I  89  CYS I 118  ILE I 119                    
SITE     2 AD6  9 TYR I 120  CYS I 121  GLY I 122  CYS I 124                    
SITE     3 AD6  9 GLU I 135                                                     
SITE     1 AD7  9 CYS I  79  ILE I  80  ALA I  81  CYS I  82                    
SITE     2 AD7  9 LEU I  84  CYS I  85  ILE I  96  CYS I 128                    
SITE     3 AD7  9 ILE I 133                                                     
SITE     1 AD8  9 GLN L 170  LEU L 173  TYR L 174  GLY L 228                    
SITE     2 AD8  9 LEU L 229  ILE L 533  HIS L 534  ASN l  86                    
SITE     3 AD8  9 ARG l  87                                                     
SITE     1 AD9 18 SER L  22  MET L  23  ARG L 116  LYS L 119                    
SITE     2 AD9 18 TYR L 120  LEU L 123  ILE L 142  MET L 150                    
SITE     3 AD9 18 LEU L 153  CDL L 703  3PE L 704  PRO M 353                    
SITE     4 AD9 18 THR M 357  LEU g  68  LEU h  22  MET h  25                    
SITE     5 AD9 18 GLY h  33  ILE h  37                                          
SITE     1 AE1 17 TRP L  66  ASN L 136  PHE L 138  CDL L 702                    
SITE     2 AE1 17 3PE L 704  3PE M 503  THR g  73  ALA g  76                    
SITE     3 AE1 17 THR h  41  ASN h  44  ILE h  45  GLU h  49                    
SITE     4 AE1 17 HIS h  69  TRP i  79  TYR i  83  HIS i  88                    
SITE     5 AE1 17 ARG p  48                                                     
SITE     1 AE2  9 THR L  65  TRP L  66  CDL L 702  CDL L 703                    
SITE     2 AE2  9 GLU h  49  PHE i  80  TYR i  84  HIS i  88                    
SITE     3 AE2  9 LYS i  92                                                     
SITE     1 AE3 10 TYR D  20  ILE L 562  LYS L 564  SER L 567                    
SITE     2 AE3 10 HIS L 570  ILE M 155  VAL M 212  MET N 284                    
SITE     3 AE3 10 MET N 285  PHE N 291                                          
SITE     1 AE4  7 ILE M 162  LEU M 166  SER M 191  LEU N 276                    
SITE     2 AE4  7 ILE N 277  THR N 280  TRP Y 132                               
SITE     1 AE5 10 TRP L  66  CDL L 703  TRP M  71  PRO M 371                    
SITE     2 AE5 10 ILE M 445  LEU M 446  LEU M 447  THR M 449                    
SITE     3 AE5 10 SER M 450  THR g  72                                          
SITE     1 AE6 12 LYS M   3  LEU M  33  LEU M  36  THR M  40                    
SITE     2 AE6 12 PHE f  19  CYS f  23  ARG f  27  PHE g  62                    
SITE     3 AE6 12 ILE g  66  PHE g  70  PHE h  79  TYR h  80                    
SITE     1 AE7 13 TRP M  16  ASN M  88  SER M  97  MET M  98                    
SITE     2 AE7 13 3PE M 506  TRP N 234  PRO N 238  LEU N 241                    
SITE     3 AE7 13 LEU N 246  SER N 301  MET N 304  ASN O 294                    
SITE     4 AE7 13 MET d  47                                                     
SITE     1 AE8  7 TRP M  16  3PE M 505  LYS O 303  CYS d  40                    
SITE     2 AE8  7 LEU d  43  VAL d  53  ARG d  55                               
SITE     1 AE9 13 MET M  55  ILE M 120  PRO N 256  LEU N 337                    
SITE     2 AE9 13 TRP X 169  THR X 170  VAL X 171  ASN d  27                    
SITE     3 AE9 13 PRO d  29  TYR d  33  PHE f  21  LYS f  28                    
SITE     4 AE9 13 LYS f  32                                                     
SITE     1 AF1 10 LEU L 576  ILE L 598  MET N 156  THR N 160                    
SITE     2 AF1 10 MET N 164  GLY Y  35  TYR Y  38  SER Y  39                    
SITE     3 AF1 10 ASN Y  43  TYR Y  58                                          
SITE     1 AF2 11 ILE O  31  CYS O  32  GLY O  34  ASN O  36                    
SITE     2 AF2 11 TYR O  83  GLN O  97  LEU O 100  ARG O 104                    
SITE     3 AF2 11 PHE O 134  GLU O 191  TYR O 198                               
SITE     1 AF3 11 GLN A  26  ILE B  47  LEU B 183  ILE B 185                    
SITE     2 AF3 11 TRP B 186  ARG B 189  MET H  53  PHE H  56                    
SITE     3 AF3 11 ASP P  55  PHE P 275  GLU P 276                               
SITE     1 AF4 18 ARG B 189  THR P  27  GLY P  28  PHE P  29                    
SITE     2 AF4 18 ARG P  50  CYS P  51  LEU P  94  ILE P  95                    
SITE     3 AF4 18 GLY P  96  ARG P  97  PHE P 104  VAL P 109                    
SITE     4 AF4 18 VAL P 132  HIS P 134  LYS P 149  SER P 169                    
SITE     5 AF4 18 ILE P 171  ARG P 177                                          
SITE     1 AF5  4 CYS R  59  HIS R  68  CYS R  84  CYS R  87                    
SITE     1 AF6 11 SER T  44  LYS W  31  THR W  48  ILE W  56                    
SITE     2 AF6 11 GLY W  61  PHE W  69  ALA W  73  VAL W  75                    
SITE     3 AF6 11 GLU W  91  VAL W 105  PHE W 108                               
SITE     1 AF7 13 ASP U  43  SER U  44  HIS n  11  GLN n  12                    
SITE     2 AF7 13 VAL n  15  ARG n  46  PHE n  47  HIS n  50                    
SITE     3 AF7 13 LYS n  51  ALA n  66  GLU n  69  PHE n  70                    
SITE     4 AF7 13 ASN n  73                                                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
HETATM    1  N   FME A   1     200.238 273.367 268.049  1.00 42.38           N  
HETATM    2  CN  FME A   1     200.560 272.069 267.729  1.00 42.38           C  
HETATM    3  O1  FME A   1     201.495 271.458 268.269  1.00 42.38           O  
HETATM    4  CA  FME A   1     200.952 274.115 269.039  1.00 42.38           C  
HETATM    5  CB  FME A   1     200.450 275.556 269.218  1.00 42.38           C  
HETATM    6  CG  FME A   1     201.451 276.428 269.931  1.00 42.38           C  
HETATM    7  SD  FME A   1     201.992 277.653 268.772  1.00 42.38           S  
HETATM    8  CE  FME A   1     201.501 279.151 269.535  1.00 42.38           C  
HETATM    9  C   FME A   1     200.867 273.471 270.408  1.00 42.38           C  
HETATM   10  O   FME A   1     201.796 273.466 271.211  1.00 42.38           O  
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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