GenomeNet

Database: PDB
Entry: 6G5H
LinkDB: 6G5H
Original site: 6G5H 
HEADER    RIBOSOME                                29-MAR-18   6G5H              
TITLE     CRYO-EM STRUCTURE OF A LATE HUMAN PRE-40S RIBOSOMAL SUBUNIT - MATURE  
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 18S RIBOSOMAL RNA;                                         
COMPND   3 CHAIN: 2;                                                            
COMPND   4 MOL_ID: 2;                                                           
COMPND   5 MOLECULE: 40S RIBOSOMAL PROTEIN SA;                                  
COMPND   6 CHAIN: A;                                                            
COMPND   7 SYNONYM: 37 KDA LAMININ RECEPTOR PRECURSOR,37LRP,37/67 KDA LAMININ   
COMPND   8 RECEPTOR,LRP/LR,67 KDA LAMININ RECEPTOR,67LR,COLON CARCINOMA LAMININ-
COMPND   9 BINDING PROTEIN,LAMININ RECEPTOR 1,LAMR,LAMININ-BINDING PROTEIN      
COMPND  10 PRECURSOR P40,LBP/P40,MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN MGR1-  
COMPND  11 AG,NEM/1CHD4,SMALL RIBOSOMAL SUBUNIT PROTEIN US2;                    
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: 40S RIBOSOMAL PROTEIN S3A;                                 
COMPND  14 CHAIN: B;                                                            
COMPND  15 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES1,V-FOS TRANSFORMATION    
COMPND  16 EFFECTOR PROTEIN,FTE-1;                                              
COMPND  17 MOL_ID: 4;                                                           
COMPND  18 MOLECULE: 40S RIBOSOMAL PROTEIN S2;                                  
COMPND  19 CHAIN: C;                                                            
COMPND  20 SYNONYM: 40S RIBOSOMAL PROTEIN S4,PROTEIN LLREP3,SMALL RIBOSOMAL     
COMPND  21 SUBUNIT PROTEIN US5;                                                 
COMPND  22 MOL_ID: 5;                                                           
COMPND  23 MOLECULE: 40S RIBOSOMAL PROTEIN S4, X ISOFORM;                       
COMPND  24 CHAIN: E;                                                            
COMPND  25 SYNONYM: SCR10,SINGLE COPY ABUNDANT MRNA PROTEIN,SMALL RIBOSOMAL     
COMPND  26 SUBUNIT PROTEIN ES4;                                                 
COMPND  27 MOL_ID: 6;                                                           
COMPND  28 MOLECULE: 40S RIBOSOMAL PROTEIN S6;                                  
COMPND  29 CHAIN: G;                                                            
COMPND  30 SYNONYM: PHOSPHOPROTEIN NP33,SMALL RIBOSOMAL SUBUNIT PROTEIN ES6;    
COMPND  31 MOL_ID: 7;                                                           
COMPND  32 MOLECULE: 40S RIBOSOMAL PROTEIN S7;                                  
COMPND  33 CHAIN: H;                                                            
COMPND  34 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES7;                        
COMPND  35 MOL_ID: 8;                                                           
COMPND  36 MOLECULE: 40S RIBOSOMAL PROTEIN S8;                                  
COMPND  37 CHAIN: I;                                                            
COMPND  38 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES8;                        
COMPND  39 MOL_ID: 9;                                                           
COMPND  40 MOLECULE: 40S RIBOSOMAL PROTEIN S9;                                  
COMPND  41 CHAIN: J;                                                            
COMPND  42 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US4;                        
COMPND  43 MOL_ID: 10;                                                          
COMPND  44 MOLECULE: 40S RIBOSOMAL PROTEIN S11;                                 
COMPND  45 CHAIN: L;                                                            
COMPND  46 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US17;                       
COMPND  47 MOL_ID: 11;                                                          
COMPND  48 MOLECULE: 40S RIBOSOMAL PROTEIN S13;                                 
COMPND  49 CHAIN: N;                                                            
COMPND  50 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US15;                       
COMPND  51 MOL_ID: 12;                                                          
COMPND  52 MOLECULE: 40S RIBOSOMAL PROTEIN S14;                                 
COMPND  53 CHAIN: O;                                                            
COMPND  54 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US11;                       
COMPND  55 MOL_ID: 13;                                                          
COMPND  56 MOLECULE: 40S RIBOSOMAL PROTEIN S21;                                 
COMPND  57 CHAIN: V;                                                            
COMPND  58 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES21;                       
COMPND  59 MOL_ID: 14;                                                          
COMPND  60 MOLECULE: 40S RIBOSOMAL PROTEIN S15A;                                
COMPND  61 CHAIN: W;                                                            
COMPND  62 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US8;                        
COMPND  63 MOL_ID: 15;                                                          
COMPND  64 MOLECULE: 40S RIBOSOMAL PROTEIN S23;                                 
COMPND  65 CHAIN: X;                                                            
COMPND  66 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US12;                       
COMPND  67 MOL_ID: 16;                                                          
COMPND  68 MOLECULE: 40S RIBOSOMAL PROTEIN S24;                                 
COMPND  69 CHAIN: Y;                                                            
COMPND  70 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES24;                       
COMPND  71 MOL_ID: 17;                                                          
COMPND  72 MOLECULE: 40S RIBOSOMAL PROTEIN S26;                                 
COMPND  73 CHAIN: a;                                                            
COMPND  74 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES26;                       
COMPND  75 MOL_ID: 18;                                                          
COMPND  76 MOLECULE: 40S RIBOSOMAL PROTEIN S27;                                 
COMPND  77 CHAIN: b;                                                            
COMPND  78 SYNONYM: METALLOPAN-STIMULIN 1,MPS-1,SMALL RIBOSOMAL SUBUNIT PROTEIN 
COMPND  79 ES27;                                                                
COMPND  80 MOL_ID: 19;                                                          
COMPND  81 MOLECULE: 40S RIBOSOMAL PROTEIN S29;                                 
COMPND  82 CHAIN: d;                                                            
COMPND  83 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US14;                       
COMPND  84 MOL_ID: 20;                                                          
COMPND  85 MOLECULE: 40S RIBOSOMAL PROTEIN S30;                                 
COMPND  86 CHAIN: e;                                                            
COMPND  87 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES30;                       
COMPND  88 MOL_ID: 21;                                                          
COMPND  89 MOLECULE: 60S RIBOSOMAL PROTEIN L41;                                 
COMPND  90 CHAIN: h;                                                            
COMPND  91 SYNONYM: HG12,LARGE RIBOSOMAL SUBUNIT PROTEIN EL41;                  
COMPND  92 MOL_ID: 22;                                                          
COMPND  93 MOLECULE: 40S RIBOSOMAL PROTEIN S3;                                  
COMPND  94 CHAIN: D;                                                            
COMPND  95 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US3;                        
COMPND  96 EC: 4.2.99.18;                                                       
COMPND  97 MOL_ID: 23;                                                          
COMPND  98 MOLECULE: 40S RIBOSOMAL PROTEIN S5;                                  
COMPND  99 CHAIN: F;                                                            
COMPND 100 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US7;                        
COMPND 101 MOL_ID: 24;                                                          
COMPND 102 MOLECULE: 40S RIBOSOMAL PROTEIN S10;                                 
COMPND 103 CHAIN: K;                                                            
COMPND 104 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES10;                       
COMPND 105 MOL_ID: 25;                                                          
COMPND 106 MOLECULE: 40S RIBOSOMAL PROTEIN S12;                                 
COMPND 107 CHAIN: M;                                                            
COMPND 108 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES12;                       
COMPND 109 MOL_ID: 26;                                                          
COMPND 110 MOLECULE: 40S RIBOSOMAL PROTEIN S15;                                 
COMPND 111 CHAIN: P;                                                            
COMPND 112 SYNONYM: RIG PROTEIN,SMALL RIBOSOMAL SUBUNIT PROTEIN US19;           
COMPND 113 MOL_ID: 27;                                                          
COMPND 114 MOLECULE: 40S RIBOSOMAL PROTEIN S16;                                 
COMPND 115 CHAIN: Q;                                                            
COMPND 116 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US9;                        
COMPND 117 MOL_ID: 28;                                                          
COMPND 118 MOLECULE: 40S RIBOSOMAL PROTEIN S17;                                 
COMPND 119 CHAIN: R;                                                            
COMPND 120 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES17;                       
COMPND 121 MOL_ID: 29;                                                          
COMPND 122 MOLECULE: 40S RIBOSOMAL PROTEIN S18;                                 
COMPND 123 CHAIN: S;                                                            
COMPND 124 SYNONYM: KE-3,KE3,SMALL RIBOSOMAL SUBUNIT PROTEIN US13;              
COMPND 125 MOL_ID: 30;                                                          
COMPND 126 MOLECULE: 40S RIBOSOMAL PROTEIN S19;                                 
COMPND 127 CHAIN: T;                                                            
COMPND 128 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES19;                       
COMPND 129 MOL_ID: 31;                                                          
COMPND 130 MOLECULE: 40S RIBOSOMAL PROTEIN S20;                                 
COMPND 131 CHAIN: U;                                                            
COMPND 132 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US10;                       
COMPND 133 MOL_ID: 32;                                                          
COMPND 134 MOLECULE: 40S RIBOSOMAL PROTEIN S25;                                 
COMPND 135 CHAIN: Z;                                                            
COMPND 136 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES25;                       
COMPND 137 MOL_ID: 33;                                                          
COMPND 138 MOLECULE: 40S RIBOSOMAL PROTEIN S28;                                 
COMPND 139 CHAIN: c;                                                            
COMPND 140 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES28;                       
COMPND 141 MOL_ID: 34;                                                          
COMPND 142 MOLECULE: RIBOSOMAL PROTEIN S27A;                                    
COMPND 143 CHAIN: f;                                                            
COMPND 144 MOL_ID: 35;                                                          
COMPND 145 MOLECULE: RECEPTOR OF ACTIVATED PROTEIN C KINASE 1;                  
COMPND 146 CHAIN: g;                                                            
COMPND 147 SYNONYM: CELL PROLIFERATION-INDUCING GENE 21 PROTEIN,GUANINE         
COMPND 148 NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2-LIKE 1,GUANINE NUCLEOTIDE- 
COMPND 149 BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 12.3,HUMAN LUNG CANCER     
COMPND 150 ONCOGENE 7 PROTEIN,HLC-7,RECEPTOR FOR ACTIVATED C KINASE,SMALL       
COMPND 151 RIBOSOMAL SUBUNIT PROTEIN RACK1                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_TAXID: 9606;                                                
SOURCE   4 CELL_LINE: HEK293;                                                   
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   7 ORGANISM_COMMON: HUMAN;                                              
SOURCE   8 ORGANISM_TAXID: 9606;                                                
SOURCE   9 CELL_LINE: HEK293;                                                   
SOURCE  10 MOL_ID: 3;                                                           
SOURCE  11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  12 ORGANISM_COMMON: HUMAN;                                              
SOURCE  13 ORGANISM_TAXID: 9606;                                                
SOURCE  14 CELL_LINE: HEK293;                                                   
SOURCE  15 MOL_ID: 4;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 CELL_LINE: HEK293;                                                   
SOURCE  20 MOL_ID: 5;                                                           
SOURCE  21 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  22 ORGANISM_COMMON: HUMAN;                                              
SOURCE  23 ORGANISM_TAXID: 9606;                                                
SOURCE  24 CELL_LINE: HEK293;                                                   
SOURCE  25 MOL_ID: 6;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 CELL_LINE: HEK293;                                                   
SOURCE  30 MOL_ID: 7;                                                           
SOURCE  31 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  32 ORGANISM_COMMON: HUMAN;                                              
SOURCE  33 ORGANISM_TAXID: 9606;                                                
SOURCE  34 CELL_LINE: HEK293;                                                   
SOURCE  35 MOL_ID: 8;                                                           
SOURCE  36 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  37 ORGANISM_COMMON: HUMAN;                                              
SOURCE  38 ORGANISM_TAXID: 9606;                                                
SOURCE  39 CELL_LINE: HEK293;                                                   
SOURCE  40 MOL_ID: 9;                                                           
SOURCE  41 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  42 ORGANISM_COMMON: HUMAN;                                              
SOURCE  43 ORGANISM_TAXID: 9606;                                                
SOURCE  44 CELL_LINE: HEK293;                                                   
SOURCE  45 MOL_ID: 10;                                                          
SOURCE  46 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  47 ORGANISM_COMMON: HUMAN;                                              
SOURCE  48 ORGANISM_TAXID: 9606;                                                
SOURCE  49 CELL_LINE: HEK293;                                                   
SOURCE  50 MOL_ID: 11;                                                          
SOURCE  51 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  52 ORGANISM_COMMON: HUMAN;                                              
SOURCE  53 ORGANISM_TAXID: 9606;                                                
SOURCE  54 CELL_LINE: HEK293;                                                   
SOURCE  55 MOL_ID: 12;                                                          
SOURCE  56 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  57 ORGANISM_COMMON: HUMAN;                                              
SOURCE  58 ORGANISM_TAXID: 9606;                                                
SOURCE  59 CELL_LINE: HEK293;                                                   
SOURCE  60 MOL_ID: 13;                                                          
SOURCE  61 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  62 ORGANISM_COMMON: HUMAN;                                              
SOURCE  63 ORGANISM_TAXID: 9606;                                                
SOURCE  64 CELL_LINE: HEK293;                                                   
SOURCE  65 MOL_ID: 14;                                                          
SOURCE  66 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  67 ORGANISM_COMMON: HUMAN;                                              
SOURCE  68 ORGANISM_TAXID: 9606;                                                
SOURCE  69 CELL_LINE: HEK293;                                                   
SOURCE  70 MOL_ID: 15;                                                          
SOURCE  71 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  72 ORGANISM_COMMON: HUMAN;                                              
SOURCE  73 ORGANISM_TAXID: 9606;                                                
SOURCE  74 CELL_LINE: HEK293;                                                   
SOURCE  75 MOL_ID: 16;                                                          
SOURCE  76 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  77 ORGANISM_COMMON: HUMAN;                                              
SOURCE  78 ORGANISM_TAXID: 9606;                                                
SOURCE  79 CELL_LINE: HEK293;                                                   
SOURCE  80 MOL_ID: 17;                                                          
SOURCE  81 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  82 ORGANISM_COMMON: HUMAN;                                              
SOURCE  83 ORGANISM_TAXID: 9606;                                                
SOURCE  84 CELL_LINE: HEK293;                                                   
SOURCE  85 MOL_ID: 18;                                                          
SOURCE  86 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  87 ORGANISM_COMMON: HUMAN;                                              
SOURCE  88 ORGANISM_TAXID: 9606;                                                
SOURCE  89 CELL_LINE: HEK293;                                                   
SOURCE  90 MOL_ID: 19;                                                          
SOURCE  91 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  92 ORGANISM_COMMON: HUMAN;                                              
SOURCE  93 ORGANISM_TAXID: 9606;                                                
SOURCE  94 CELL_LINE: HEK293;                                                   
SOURCE  95 MOL_ID: 20;                                                          
SOURCE  96 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  97 ORGANISM_COMMON: HUMAN;                                              
SOURCE  98 ORGANISM_TAXID: 9606;                                                
SOURCE  99 CELL_LINE: HEK293;                                                   
SOURCE 100 MOL_ID: 21;                                                          
SOURCE 101 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 102 ORGANISM_COMMON: HUMAN;                                              
SOURCE 103 ORGANISM_TAXID: 9606;                                                
SOURCE 104 CELL_LINE: HEK293;                                                   
SOURCE 105 MOL_ID: 22;                                                          
SOURCE 106 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 107 ORGANISM_COMMON: HUMAN;                                              
SOURCE 108 ORGANISM_TAXID: 9606;                                                
SOURCE 109 CELL_LINE: HEK293;                                                   
SOURCE 110 MOL_ID: 23;                                                          
SOURCE 111 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 112 ORGANISM_COMMON: HUMAN;                                              
SOURCE 113 ORGANISM_TAXID: 9606;                                                
SOURCE 114 CELL_LINE: HEK293;                                                   
SOURCE 115 MOL_ID: 24;                                                          
SOURCE 116 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 117 ORGANISM_COMMON: HUMAN;                                              
SOURCE 118 ORGANISM_TAXID: 9606;                                                
SOURCE 119 CELL_LINE: HEK293;                                                   
SOURCE 120 MOL_ID: 25;                                                          
SOURCE 121 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 122 ORGANISM_COMMON: HUMAN;                                              
SOURCE 123 ORGANISM_TAXID: 9606;                                                
SOURCE 124 CELL_LINE: HEK293;                                                   
SOURCE 125 MOL_ID: 26;                                                          
SOURCE 126 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 127 ORGANISM_COMMON: HUMAN;                                              
SOURCE 128 ORGANISM_TAXID: 9606;                                                
SOURCE 129 CELL_LINE: HEK293;                                                   
SOURCE 130 MOL_ID: 27;                                                          
SOURCE 131 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 132 ORGANISM_COMMON: HUMAN;                                              
SOURCE 133 ORGANISM_TAXID: 9606;                                                
SOURCE 134 CELL_LINE: HEK293;                                                   
SOURCE 135 MOL_ID: 28;                                                          
SOURCE 136 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 137 ORGANISM_COMMON: HUMAN;                                              
SOURCE 138 ORGANISM_TAXID: 9606;                                                
SOURCE 139 CELL_LINE: HEK293;                                                   
SOURCE 140 MOL_ID: 29;                                                          
SOURCE 141 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 142 ORGANISM_COMMON: HUMAN;                                              
SOURCE 143 ORGANISM_TAXID: 9606;                                                
SOURCE 144 CELL_LINE: HEK293;                                                   
SOURCE 145 MOL_ID: 30;                                                          
SOURCE 146 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 147 ORGANISM_COMMON: HUMAN;                                              
SOURCE 148 ORGANISM_TAXID: 9606;                                                
SOURCE 149 CELL_LINE: HEK293;                                                   
SOURCE 150 MOL_ID: 31;                                                          
SOURCE 151 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 152 ORGANISM_COMMON: HUMAN;                                              
SOURCE 153 ORGANISM_TAXID: 9606;                                                
SOURCE 154 CELL_LINE: HEK293;                                                   
SOURCE 155 MOL_ID: 32;                                                          
SOURCE 156 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 157 ORGANISM_COMMON: HUMAN;                                              
SOURCE 158 ORGANISM_TAXID: 9606;                                                
SOURCE 159 CELL_LINE: HEK293;                                                   
SOURCE 160 MOL_ID: 33;                                                          
SOURCE 161 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 162 ORGANISM_COMMON: HUMAN;                                              
SOURCE 163 ORGANISM_TAXID: 9606;                                                
SOURCE 164 CELL_LINE: HEK293;                                                   
SOURCE 165 MOL_ID: 34;                                                          
SOURCE 166 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 167 ORGANISM_COMMON: HUMAN;                                              
SOURCE 168 ORGANISM_TAXID: 9606;                                                
SOURCE 169 CELL_LINE: HEK293;                                                   
SOURCE 170 MOL_ID: 35;                                                          
SOURCE 171 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 172 ORGANISM_COMMON: HUMAN;                                              
SOURCE 173 ORGANISM_TAXID: 9606;                                                
SOURCE 174 CELL_LINE: HEK293                                                    
KEYWDS    40S, PRE-40S, RIBOSOME BIOGENESIS, RIBOSOME                           
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    M.AMEISMEIER,J.CHENG,O.BERNINGHAUSEN,R.BECKMANN                       
REVDAT   4   11-DEC-19 6G5H    1       CRYST1 SCALE                             
REVDAT   3   27-JUN-18 6G5H    1       JRNL                                     
REVDAT   2   20-JUN-18 6G5H    1       JRNL                                     
REVDAT   1   06-JUN-18 6G5H    0                                                
JRNL        AUTH   M.AMEISMEIER,J.CHENG,O.BERNINGHAUSEN,R.BECKMANN              
JRNL        TITL   VISUALIZING LATE STATES OF HUMAN 40S RIBOSOMAL SUBUNIT       
JRNL        TITL 2 MATURATION.                                                  
JRNL        REF    NATURE                        V. 558   249 2018              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   29875412                                                     
JRNL        DOI    10.1038/S41586-018-0193-0                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.600                          
REMARK   3   NUMBER OF PARTICLES               : 70822                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6G5H COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 02-APR-18.                  
REMARK 100 THE DEPOSITION ID IS D_1200009425.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : CRYO-EM STRUCTURE OF A LATE       
REMARK 245                                    HUMAN PRE-40S RIBOSOMAL SUBUNIT   
REMARK 245                                    - MATURE                          
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.60                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : FEI FALCON II (4K X 4K)        
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 2.50                           
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 35-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: 2, A, B, C, E, G, H, I, J, L,         
REMARK 350                    AND CHAINS: N, O, V, W, X, Y, a, b, d,            
REMARK 350                    AND CHAINS: e, h, D, F, K, M, P, Q, R, S,         
REMARK 350                    AND CHAINS: T, U, Z, c, f, g                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465       C 2   131                                                      
REMARK 465       U 2   132                                                      
REMARK 465       C 2   133                                                      
REMARK 465       C 2   134                                                      
REMARK 465       U 2   135                                                      
REMARK 465       C 2   136                                                      
REMARK 465       U 2   137                                                      
REMARK 465       C 2   138                                                      
REMARK 465       C 2   139                                                      
REMARK 465       A 2   226                                                      
REMARK 465       U 2   227                                                      
REMARK 465       C 2   228                                                      
REMARK 465       A 2   229                                                      
REMARK 465       A 2   230                                                      
REMARK 465       A 2   231                                                      
REMARK 465       A 2   232                                                      
REMARK 465       C 2   233                                                      
REMARK 465       C 2   234                                                      
REMARK 465       A 2   235                                                      
REMARK 465       A 2   236                                                      
REMARK 465       C 2   237                                                      
REMARK 465       C 2   238                                                      
REMARK 465       C 2   239                                                      
REMARK 465       G 2   240                                                      
REMARK 465       G 2   241                                                      
REMARK 465       U 2   242                                                      
REMARK 465       C 2   243                                                      
REMARK 465       A 2   244                                                      
REMARK 465       G 2   245                                                      
REMARK 465       C 2   246                                                      
REMARK 465       C 2   247                                                      
REMARK 465       C 2   248                                                      
REMARK 465       C 2   249                                                      
REMARK 465       U 2   250                                                      
REMARK 465       C 2   251                                                      
REMARK 465       U 2   252                                                      
REMARK 465       C 2   253                                                      
REMARK 465       C 2   254                                                      
REMARK 465       G 2   255                                                      
REMARK 465       G 2   256                                                      
REMARK 465       C 2   257                                                      
REMARK 465       C 2   258                                                      
REMARK 465       C 2   259                                                      
REMARK 465       C 2   260                                                      
REMARK 465       G 2   261                                                      
REMARK 465       G 2   262                                                      
REMARK 465       C 2   263                                                      
REMARK 465       C 2   264                                                      
REMARK 465       G 2   265                                                      
REMARK 465       G 2   266                                                      
REMARK 465       G 2   267                                                      
REMARK 465       G 2   268                                                      
REMARK 465       G 2   269                                                      
REMARK 465       G 2   270                                                      
REMARK 465       C 2   271                                                      
REMARK 465       G 2   272                                                      
REMARK 465       G 2   273                                                      
REMARK 465       G 2   274                                                      
REMARK 465       C 2   275                                                      
REMARK 465       C 2   276                                                      
REMARK 465       G 2   277                                                      
REMARK 465       C 2   278                                                      
REMARK 465       G 2   279                                                      
REMARK 465       G 2   280                                                      
REMARK 465       C 2   281                                                      
REMARK 465       G 2   282                                                      
REMARK 465       G 2   283                                                      
REMARK 465       C 2   284                                                      
REMARK 465       U 2   285                                                      
REMARK 465       U 2   286                                                      
REMARK 465       C 2   323                                                      
REMARK 465       C 2   324                                                      
REMARK 465       C 2   325                                                      
REMARK 465       C 2   326                                                      
REMARK 465       G 2   327                                                      
REMARK 465       U 2   328                                                      
REMARK 465       U 2   689                                                      
REMARK 465       G 2   690                                                      
REMARK 465       G 2   691                                                      
REMARK 465       G 2   692                                                      
REMARK 465       A 2   693                                                      
REMARK 465       G 2   694                                                      
REMARK 465       C 2   695                                                      
REMARK 465       G 2   696                                                      
REMARK 465       G 2   697                                                      
REMARK 465       G 2   698                                                      
REMARK 465       C 2   699                                                      
REMARK 465       G 2   700                                                      
REMARK 465       G 2   701                                                      
REMARK 465       G 2   702                                                      
REMARK 465       C 2   703                                                      
REMARK 465       G 2   704                                                      
REMARK 465       G 2   705                                                      
REMARK 465       U 2   706                                                      
REMARK 465       C 2   707                                                      
REMARK 465       C 2   708                                                      
REMARK 465       G 2   709                                                      
REMARK 465       C 2   710                                                      
REMARK 465       C 2   711                                                      
REMARK 465       G 2   712                                                      
REMARK 465       C 2   713                                                      
REMARK 465       G 2   714                                                      
REMARK 465       A 2   715                                                      
REMARK 465       G 2   716                                                      
REMARK 465       G 2   717                                                      
REMARK 465       C 2   718                                                      
REMARK 465       G 2   719                                                      
REMARK 465       A 2   720                                                      
REMARK 465       G 2   721                                                      
REMARK 465       C 2   722                                                      
REMARK 465       C 2   723                                                      
REMARK 465       A 2   724                                                      
REMARK 465       C 2   725                                                      
REMARK 465       C 2   726                                                      
REMARK 465       G 2   727                                                      
REMARK 465       C 2   728                                                      
REMARK 465       C 2   729                                                      
REMARK 465       C 2   730                                                      
REMARK 465       G 2   731                                                      
REMARK 465       U 2   732                                                      
REMARK 465       C 2   733                                                      
REMARK 465       C 2   734                                                      
REMARK 465       C 2   735                                                      
REMARK 465       C 2   736                                                      
REMARK 465       G 2   737                                                      
REMARK 465       C 2   738                                                      
REMARK 465       C 2   739                                                      
REMARK 465       C 2   740                                                      
REMARK 465       C 2   741                                                      
REMARK 465       U 2   742                                                      
REMARK 465       U 2   743                                                      
REMARK 465       G 2   744                                                      
REMARK 465       C 2   745                                                      
REMARK 465       C 2   753                                                      
REMARK 465       G 2   754                                                      
REMARK 465       C 2   755                                                      
REMARK 465       C 2   756                                                      
REMARK 465       C 2   757                                                      
REMARK 465       C 2   758                                                      
REMARK 465       C 2   759                                                      
REMARK 465       U 2   760                                                      
REMARK 465       C 2   761                                                      
REMARK 465       G 2   762                                                      
REMARK 465       A 2   763                                                      
REMARK 465       U 2   764                                                      
REMARK 465       G 2   765                                                      
REMARK 465       C 2   766                                                      
REMARK 465       U 2   767                                                      
REMARK 465       C 2   768                                                      
REMARK 465       U 2   769                                                      
REMARK 465       U 2   770                                                      
REMARK 465       A 2   771                                                      
REMARK 465       G 2   772                                                      
REMARK 465       C 2   773                                                      
REMARK 465       U 2   774                                                      
REMARK 465       G 2   775                                                      
REMARK 465       A 2   776                                                      
REMARK 465       G 2   777                                                      
REMARK 465       U 2   778                                                      
REMARK 465       G 2   779                                                      
REMARK 465       U 2   780                                                      
REMARK 465       C 2   781                                                      
REMARK 465       C 2   782                                                      
REMARK 465       C 2   783                                                      
REMARK 465       G 2   784                                                      
REMARK 465       C 2   785                                                      
REMARK 465       G 2   786                                                      
REMARK 465       G 2   787                                                      
REMARK 465       G 2   788                                                      
REMARK 465       G 2   789                                                      
REMARK 465       C 2   790                                                      
REMARK 465       C 2   835                                                      
REMARK 465       G 2   836                                                      
REMARK 465       A 2   837                                                      
REMARK 465       G 2   838                                                      
REMARK 465       C 2   839                                                      
REMARK 465       C 2   840                                                      
REMARK 465       C 2  1417                                                      
REMARK 465       C 2  1418                                                      
REMARK 465       C 2  1419                                                      
REMARK 465       G 2  1420                                                      
REMARK 465       A 2  1421                                                      
REMARK 465       G 2  1422                                                      
REMARK 465       C 2  1423                                                      
REMARK 465       C 2  1433                                                      
REMARK 465       C 2  1434                                                      
REMARK 465       C 2  1435                                                      
REMARK 465       C 2  1436                                                      
REMARK 465       C 2  1437                                                      
REMARK 465       G 2  1552                                                      
REMARK 465       C 2  1553                                                      
REMARK 465       C 2  1554                                                      
REMARK 465       U 2  1555                                                      
REMARK 465       A 2  1556                                                      
REMARK 465       C 2  1557                                                      
REMARK 465       C 2  1763                                                      
REMARK 465       G 2  1764                                                      
REMARK 465       G 2  1765                                                      
REMARK 465       C 2  1766                                                      
REMARK 465       C 2  1767                                                      
REMARK 465       C 2  1768                                                      
REMARK 465       A 2  1769                                                      
REMARK 465       C 2  1770                                                      
REMARK 465     MET A     1                                                      
REMARK 465     GLU A   208                                                      
REMARK 465     GLU A   209                                                      
REMARK 465     ILE A   210                                                      
REMARK 465     GLU A   211                                                      
REMARK 465     LYS A   212                                                      
REMARK 465     GLU A   213                                                      
REMARK 465     GLU A   214                                                      
REMARK 465     GLN A   215                                                      
REMARK 465     ALA A   216                                                      
REMARK 465     ALA A   217                                                      
REMARK 465     ALA A   218                                                      
REMARK 465     GLU A   219                                                      
REMARK 465     LYS A   220                                                      
REMARK 465     ALA A   221                                                      
REMARK 465     VAL A   222                                                      
REMARK 465     THR A   223                                                      
REMARK 465     LYS A   224                                                      
REMARK 465     GLU A   225                                                      
REMARK 465     GLU A   226                                                      
REMARK 465     PHE A   227                                                      
REMARK 465     GLN A   228                                                      
REMARK 465     GLY A   229                                                      
REMARK 465     GLU A   230                                                      
REMARK 465     TRP A   231                                                      
REMARK 465     THR A   232                                                      
REMARK 465     ALA A   233                                                      
REMARK 465     PRO A   234                                                      
REMARK 465     ALA A   235                                                      
REMARK 465     PRO A   236                                                      
REMARK 465     GLU A   237                                                      
REMARK 465     PHE A   238                                                      
REMARK 465     THR A   239                                                      
REMARK 465     ALA A   240                                                      
REMARK 465     THR A   241                                                      
REMARK 465     GLN A   242                                                      
REMARK 465     PRO A   243                                                      
REMARK 465     GLU A   244                                                      
REMARK 465     VAL A   245                                                      
REMARK 465     ALA A   246                                                      
REMARK 465     ASP A   247                                                      
REMARK 465     TRP A   248                                                      
REMARK 465     SER A   249                                                      
REMARK 465     GLU A   250                                                      
REMARK 465     GLY A   251                                                      
REMARK 465     VAL A   252                                                      
REMARK 465     GLN A   253                                                      
REMARK 465     VAL A   254                                                      
REMARK 465     PRO A   255                                                      
REMARK 465     SER A   256                                                      
REMARK 465     VAL A   257                                                      
REMARK 465     PRO A   258                                                      
REMARK 465     ILE A   259                                                      
REMARK 465     GLN A   260                                                      
REMARK 465     GLN A   261                                                      
REMARK 465     PHE A   262                                                      
REMARK 465     PRO A   263                                                      
REMARK 465     THR A   264                                                      
REMARK 465     GLU A   265                                                      
REMARK 465     ASP A   266                                                      
REMARK 465     TRP A   267                                                      
REMARK 465     SER A   268                                                      
REMARK 465     ALA A   269                                                      
REMARK 465     GLN A   270                                                      
REMARK 465     PRO A   271                                                      
REMARK 465     ALA A   272                                                      
REMARK 465     THR A   273                                                      
REMARK 465     GLU A   274                                                      
REMARK 465     ASP A   275                                                      
REMARK 465     TRP A   276                                                      
REMARK 465     SER A   277                                                      
REMARK 465     ALA A   278                                                      
REMARK 465     ALA A   279                                                      
REMARK 465     PRO A   280                                                      
REMARK 465     THR A   281                                                      
REMARK 465     ALA A   282                                                      
REMARK 465     GLN A   283                                                      
REMARK 465     ALA A   284                                                      
REMARK 465     THR A   285                                                      
REMARK 465     GLU A   286                                                      
REMARK 465     TRP A   287                                                      
REMARK 465     VAL A   288                                                      
REMARK 465     GLY A   289                                                      
REMARK 465     ALA A   290                                                      
REMARK 465     THR A   291                                                      
REMARK 465     THR A   292                                                      
REMARK 465     ASP A   293                                                      
REMARK 465     TRP A   294                                                      
REMARK 465     SER A   295                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     VAL B     3                                                      
REMARK 465     GLY B     4                                                      
REMARK 465     LYS B     5                                                      
REMARK 465     ASN B     6                                                      
REMARK 465     LYS B     7                                                      
REMARK 465     ARG B     8                                                      
REMARK 465     LEU B     9                                                      
REMARK 465     THR B    10                                                      
REMARK 465     LYS B    11                                                      
REMARK 465     GLY B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     LYS B    14                                                      
REMARK 465     LYS B    15                                                      
REMARK 465     GLY B    16                                                      
REMARK 465     ALA B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     LYS B    19                                                      
REMARK 465     LYS B    20                                                      
REMARK 465     GLU B   234                                                      
REMARK 465     GLY B   235                                                      
REMARK 465     SER B   236                                                      
REMARK 465     SER B   237                                                      
REMARK 465     SER B   238                                                      
REMARK 465     GLY B   239                                                      
REMARK 465     LYS B   240                                                      
REMARK 465     ALA B   241                                                      
REMARK 465     THR B   242                                                      
REMARK 465     GLY B   243                                                      
REMARK 465     ASP B   244                                                      
REMARK 465     GLU B   245                                                      
REMARK 465     THR B   246                                                      
REMARK 465     GLY B   247                                                      
REMARK 465     ALA B   248                                                      
REMARK 465     LYS B   249                                                      
REMARK 465     VAL B   250                                                      
REMARK 465     GLU B   251                                                      
REMARK 465     ARG B   252                                                      
REMARK 465     ALA B   253                                                      
REMARK 465     ASP B   254                                                      
REMARK 465     GLY B   255                                                      
REMARK 465     TYR B   256                                                      
REMARK 465     GLU B   257                                                      
REMARK 465     PRO B   258                                                      
REMARK 465     PRO B   259                                                      
REMARK 465     VAL B   260                                                      
REMARK 465     GLN B   261                                                      
REMARK 465     GLU B   262                                                      
REMARK 465     SER B   263                                                      
REMARK 465     VAL B   264                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     ASP C     3                                                      
REMARK 465     ASP C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     GLY C     6                                                      
REMARK 465     ALA C     7                                                      
REMARK 465     ALA C     8                                                      
REMARK 465     GLY C     9                                                      
REMARK 465     GLY C    10                                                      
REMARK 465     PRO C    11                                                      
REMARK 465     GLY C    12                                                      
REMARK 465     GLY C    13                                                      
REMARK 465     PRO C    14                                                      
REMARK 465     GLY C    15                                                      
REMARK 465     GLY C    16                                                      
REMARK 465     PRO C    17                                                      
REMARK 465     GLY C    18                                                      
REMARK 465     MET C    19                                                      
REMARK 465     GLY C    20                                                      
REMARK 465     ASN C    21                                                      
REMARK 465     ARG C    22                                                      
REMARK 465     GLY C    23                                                      
REMARK 465     GLY C    24                                                      
REMARK 465     PHE C    25                                                      
REMARK 465     ARG C    26                                                      
REMARK 465     GLY C    27                                                      
REMARK 465     GLY C    28                                                      
REMARK 465     PHE C    29                                                      
REMARK 465     GLY C    30                                                      
REMARK 465     SER C    31                                                      
REMARK 465     GLY C    32                                                      
REMARK 465     ILE C    33                                                      
REMARK 465     ARG C    34                                                      
REMARK 465     GLY C    35                                                      
REMARK 465     ARG C    36                                                      
REMARK 465     GLY C    37                                                      
REMARK 465     ARG C    38                                                      
REMARK 465     GLY C    39                                                      
REMARK 465     ARG C    40                                                      
REMARK 465     GLY C    41                                                      
REMARK 465     ARG C    42                                                      
REMARK 465     GLY C    43                                                      
REMARK 465     ARG C    44                                                      
REMARK 465     GLY C    45                                                      
REMARK 465     ARG C    46                                                      
REMARK 465     GLY C    47                                                      
REMARK 465     ARG C    48                                                      
REMARK 465     GLY C    49                                                      
REMARK 465     ALA C    50                                                      
REMARK 465     ARG C    51                                                      
REMARK 465     GLY C    52                                                      
REMARK 465     GLY C    53                                                      
REMARK 465     LYS C    54                                                      
REMARK 465     ALA C    55                                                      
REMARK 465     GLU C    56                                                      
REMARK 465     ASP C    57                                                      
REMARK 465     LYS C    58                                                      
REMARK 465     HIS C   277                                                      
REMARK 465     THR C   278                                                      
REMARK 465     ARG C   279                                                      
REMARK 465     VAL C   280                                                      
REMARK 465     SER C   281                                                      
REMARK 465     VAL C   282                                                      
REMARK 465     GLN C   283                                                      
REMARK 465     ARG C   284                                                      
REMARK 465     THR C   285                                                      
REMARK 465     GLN C   286                                                      
REMARK 465     ALA C   287                                                      
REMARK 465     PRO C   288                                                      
REMARK 465     ALA C   289                                                      
REMARK 465     VAL C   290                                                      
REMARK 465     ALA C   291                                                      
REMARK 465     THR C   292                                                      
REMARK 465     THR C   293                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ARG G   231                                                      
REMARK 465     ARG G   232                                                      
REMARK 465     ARG G   233                                                      
REMARK 465     LEU G   234                                                      
REMARK 465     SER G   235                                                      
REMARK 465     SER G   236                                                      
REMARK 465     LEU G   237                                                      
REMARK 465     ARG G   238                                                      
REMARK 465     ALA G   239                                                      
REMARK 465     SER G   240                                                      
REMARK 465     THR G   241                                                      
REMARK 465     SER G   242                                                      
REMARK 465     LYS G   243                                                      
REMARK 465     SER G   244                                                      
REMARK 465     GLU G   245                                                      
REMARK 465     SER G   246                                                      
REMARK 465     SER G   247                                                      
REMARK 465     GLN G   248                                                      
REMARK 465     LYS G   249                                                      
REMARK 465     MET H     1                                                      
REMARK 465     PHE H     2                                                      
REMARK 465     SER H     3                                                      
REMARK 465     SER H     4                                                      
REMARK 465     SER H     5                                                      
REMARK 465     ALA H     6                                                      
REMARK 465     LYS H     7                                                      
REMARK 465     LEU H   194                                                      
REMARK 465     MET I     1                                                      
REMARK 465     GLY I   207                                                      
REMARK 465     LYS I   208                                                      
REMARK 465     MET J     1                                                      
REMARK 465     GLN J   182                                                      
REMARK 465     GLY J   183                                                      
REMARK 465     GLY J   184                                                      
REMARK 465     ALA J   185                                                      
REMARK 465     GLY J   186                                                      
REMARK 465     ALA J   187                                                      
REMARK 465     GLY J   188                                                      
REMARK 465     ASP J   189                                                      
REMARK 465     ASP J   190                                                      
REMARK 465     GLU J   191                                                      
REMARK 465     GLU J   192                                                      
REMARK 465     GLU J   193                                                      
REMARK 465     ASP J   194                                                      
REMARK 465     MET L     1                                                      
REMARK 465     LYS L   153                                                      
REMARK 465     GLN L   154                                                      
REMARK 465     PHE L   155                                                      
REMARK 465     GLN L   156                                                      
REMARK 465     LYS L   157                                                      
REMARK 465     PHE L   158                                                      
REMARK 465     MET N     1                                                      
REMARK 465     ALA N   151                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     PRO O     3                                                      
REMARK 465     ARG O     4                                                      
REMARK 465     LYS O     5                                                      
REMARK 465     GLY O     6                                                      
REMARK 465     LYS O     7                                                      
REMARK 465     GLU O     8                                                      
REMARK 465     LYS O     9                                                      
REMARK 465     LYS O    10                                                      
REMARK 465     GLU O    11                                                      
REMARK 465     GLU O    12                                                      
REMARK 465     GLN O    13                                                      
REMARK 465     VAL O    14                                                      
REMARK 465     ILE O    15                                                      
REMARK 465     SER O    16                                                      
REMARK 465     PHE V    83                                                      
REMARK 465     MET W     1                                                      
REMARK 465     MET X     1                                                      
REMARK 465     SER X   143                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     ASN Y     2                                                      
REMARK 465     ALA Y   127                                                      
REMARK 465     GLY Y   128                                                      
REMARK 465     LYS Y   129                                                      
REMARK 465     LYS Y   130                                                      
REMARK 465     PRO Y   131                                                      
REMARK 465     LYS Y   132                                                      
REMARK 465     GLU Y   133                                                      
REMARK 465     MET a     1                                                      
REMARK 465     PRO a   103                                                      
REMARK 465     ALA a   104                                                      
REMARK 465     GLY a   105                                                      
REMARK 465     ALA a   106                                                      
REMARK 465     ALA a   107                                                      
REMARK 465     PRO a   108                                                      
REMARK 465     ARG a   109                                                      
REMARK 465     PRO a   110                                                      
REMARK 465     PRO a   111                                                      
REMARK 465     PRO a   112                                                      
REMARK 465     LYS a   113                                                      
REMARK 465     PRO a   114                                                      
REMARK 465     MET a   115                                                      
REMARK 465     MET b     1                                                      
REMARK 465     HIS b    84                                                      
REMARK 465     MET d     1                                                      
REMARK 465     GLY d     2                                                      
REMARK 465     LYS e     1                                                      
REMARK 465     VAL e     2                                                      
REMARK 465     HIS e     3                                                      
REMARK 465     MET h     1                                                      
REMARK 465     MET D     1                                                      
REMARK 465     ALA D     2                                                      
REMARK 465     GLY D   228                                                      
REMARK 465     GLY D   229                                                      
REMARK 465     LYS D   230                                                      
REMARK 465     PRO D   231                                                      
REMARK 465     GLU D   232                                                      
REMARK 465     PRO D   233                                                      
REMARK 465     PRO D   234                                                      
REMARK 465     ALA D   235                                                      
REMARK 465     MET D   236                                                      
REMARK 465     PRO D   237                                                      
REMARK 465     GLN D   238                                                      
REMARK 465     PRO D   239                                                      
REMARK 465     VAL D   240                                                      
REMARK 465     PRO D   241                                                      
REMARK 465     THR D   242                                                      
REMARK 465     ALA D   243                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     GLU F     3                                                      
REMARK 465     TRP F     4                                                      
REMARK 465     GLU F     5                                                      
REMARK 465     THR F     6                                                      
REMARK 465     ALA F     7                                                      
REMARK 465     ALA F     8                                                      
REMARK 465     PRO F     9                                                      
REMARK 465     ALA F    10                                                      
REMARK 465     VAL F    11                                                      
REMARK 465     ALA F    12                                                      
REMARK 465     GLU F    13                                                      
REMARK 465     THR F    14                                                      
REMARK 465     PRO F    15                                                      
REMARK 465     MET K     1                                                      
REMARK 465     LEU K     2                                                      
REMARK 465     ARG K    98                                                      
REMARK 465     PRO K    99                                                      
REMARK 465     GLU K   100                                                      
REMARK 465     THR K   101                                                      
REMARK 465     GLY K   102                                                      
REMARK 465     ARG K   103                                                      
REMARK 465     PRO K   104                                                      
REMARK 465     ARG K   105                                                      
REMARK 465     PRO K   106                                                      
REMARK 465     LYS K   107                                                      
REMARK 465     GLY K   108                                                      
REMARK 465     LEU K   109                                                      
REMARK 465     GLU K   110                                                      
REMARK 465     GLY K   111                                                      
REMARK 465     GLU K   112                                                      
REMARK 465     ARG K   113                                                      
REMARK 465     PRO K   114                                                      
REMARK 465     ALA K   115                                                      
REMARK 465     ARG K   116                                                      
REMARK 465     LEU K   117                                                      
REMARK 465     THR K   118                                                      
REMARK 465     ARG K   119                                                      
REMARK 465     GLY K   120                                                      
REMARK 465     GLU K   121                                                      
REMARK 465     ALA K   122                                                      
REMARK 465     ASP K   123                                                      
REMARK 465     ARG K   124                                                      
REMARK 465     ASP K   125                                                      
REMARK 465     THR K   126                                                      
REMARK 465     TYR K   127                                                      
REMARK 465     ARG K   128                                                      
REMARK 465     ARG K   129                                                      
REMARK 465     SER K   130                                                      
REMARK 465     ALA K   131                                                      
REMARK 465     VAL K   132                                                      
REMARK 465     PRO K   133                                                      
REMARK 465     PRO K   134                                                      
REMARK 465     GLY K   135                                                      
REMARK 465     ALA K   136                                                      
REMARK 465     ASP K   137                                                      
REMARK 465     LYS K   138                                                      
REMARK 465     LYS K   139                                                      
REMARK 465     ALA K   140                                                      
REMARK 465     GLU K   141                                                      
REMARK 465     ALA K   142                                                      
REMARK 465     GLY K   143                                                      
REMARK 465     ALA K   144                                                      
REMARK 465     GLY K   145                                                      
REMARK 465     SER K   146                                                      
REMARK 465     ALA K   147                                                      
REMARK 465     THR K   148                                                      
REMARK 465     GLU K   149                                                      
REMARK 465     PHE K   150                                                      
REMARK 465     GLN K   151                                                      
REMARK 465     PHE K   152                                                      
REMARK 465     ARG K   153                                                      
REMARK 465     GLY K   154                                                      
REMARK 465     GLY K   155                                                      
REMARK 465     PHE K   156                                                      
REMARK 465     GLY K   157                                                      
REMARK 465     ARG K   158                                                      
REMARK 465     GLY K   159                                                      
REMARK 465     ARG K   160                                                      
REMARK 465     GLY K   161                                                      
REMARK 465     GLN K   162                                                      
REMARK 465     PRO K   163                                                      
REMARK 465     PRO K   164                                                      
REMARK 465     GLN K   165                                                      
REMARK 465     MET M     1                                                      
REMARK 465     ALA M     2                                                      
REMARK 465     GLU M     3                                                      
REMARK 465     GLU M     4                                                      
REMARK 465     GLY M     5                                                      
REMARK 465     ILE M     6                                                      
REMARK 465     ALA M     7                                                      
REMARK 465     ALA M     8                                                      
REMARK 465     GLY M     9                                                      
REMARK 465     MET P     1                                                      
REMARK 465     ALA P     2                                                      
REMARK 465     GLU P     3                                                      
REMARK 465     VAL P     4                                                      
REMARK 465     GLU P     5                                                      
REMARK 465     GLN P     6                                                      
REMARK 465     LYS P     7                                                      
REMARK 465     LYS P     8                                                      
REMARK 465     LYS P     9                                                      
REMARK 465     ARG P    10                                                      
REMARK 465     THR P    11                                                      
REMARK 465     PHE P    12                                                      
REMARK 465     ARG P    13                                                      
REMARK 465     LYS P    14                                                      
REMARK 465     ALA P   135                                                      
REMARK 465     THR P   136                                                      
REMARK 465     HIS P   137                                                      
REMARK 465     SER P   138                                                      
REMARK 465     SER P   139                                                      
REMARK 465     ARG P   140                                                      
REMARK 465     PHE P   141                                                      
REMARK 465     ILE P   142                                                      
REMARK 465     PRO P   143                                                      
REMARK 465     LEU P   144                                                      
REMARK 465     LYS P   145                                                      
REMARK 465     MET Q     1                                                      
REMARK 465     PRO Q     2                                                      
REMARK 465     SER Q     3                                                      
REMARK 465     LYS Q     4                                                      
REMARK 465     GLY Q     5                                                      
REMARK 465     PRO Q     6                                                      
REMARK 465     LEU Q     7                                                      
REMARK 465     MET R     1                                                      
REMARK 465     PRO R   134                                                      
REMARK 465     VAL R   135                                                      
REMARK 465     MET S     1                                                      
REMARK 465     SER S     2                                                      
REMARK 465     VAL S   146                                                      
REMARK 465     GLY S   147                                                      
REMARK 465     VAL S   148                                                      
REMARK 465     SER S   149                                                      
REMARK 465     LYS S   150                                                      
REMARK 465     LYS S   151                                                      
REMARK 465     LYS S   152                                                      
REMARK 465     MET T     1                                                      
REMARK 465     MET U     1                                                      
REMARK 465     ALA U     2                                                      
REMARK 465     PHE U     3                                                      
REMARK 465     LYS U     4                                                      
REMARK 465     ASP U     5                                                      
REMARK 465     THR U     6                                                      
REMARK 465     GLY U     7                                                      
REMARK 465     LYS U     8                                                      
REMARK 465     THR U     9                                                      
REMARK 465     PRO U    10                                                      
REMARK 465     VAL U    11                                                      
REMARK 465     GLU U    12                                                      
REMARK 465     PRO U    13                                                      
REMARK 465     GLU U    14                                                      
REMARK 465     VAL U    15                                                      
REMARK 465     ALA U    16                                                      
REMARK 465     ASP U   118                                                      
REMARK 465     ALA U   119                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     PRO Z     2                                                      
REMARK 465     PRO Z     3                                                      
REMARK 465     LYS Z     4                                                      
REMARK 465     ASP Z     5                                                      
REMARK 465     ASP Z     6                                                      
REMARK 465     LYS Z     7                                                      
REMARK 465     LYS Z     8                                                      
REMARK 465     LYS Z     9                                                      
REMARK 465     LYS Z    10                                                      
REMARK 465     ASP Z    11                                                      
REMARK 465     ALA Z    12                                                      
REMARK 465     GLY Z    13                                                      
REMARK 465     LYS Z    14                                                      
REMARK 465     SER Z    15                                                      
REMARK 465     ALA Z    16                                                      
REMARK 465     LYS Z    17                                                      
REMARK 465     LYS Z    18                                                      
REMARK 465     ASP Z    19                                                      
REMARK 465     LYS Z    20                                                      
REMARK 465     ASP Z    21                                                      
REMARK 465     PRO Z    22                                                      
REMARK 465     VAL Z    23                                                      
REMARK 465     ASN Z    24                                                      
REMARK 465     LYS Z    25                                                      
REMARK 465     SER Z    26                                                      
REMARK 465     GLY Z    27                                                      
REMARK 465     GLY Z    28                                                      
REMARK 465     LYS Z    29                                                      
REMARK 465     ALA Z    30                                                      
REMARK 465     LYS Z    31                                                      
REMARK 465     LYS Z    32                                                      
REMARK 465     LYS Z    33                                                      
REMARK 465     LYS Z    34                                                      
REMARK 465     TRP Z    35                                                      
REMARK 465     SER Z    36                                                      
REMARK 465     LYS Z    37                                                      
REMARK 465     GLY Z    38                                                      
REMARK 465     LYS Z    39                                                      
REMARK 465     VAL Z    40                                                      
REMARK 465     ARG Z    41                                                      
REMARK 465     LYS Z   114                                                      
REMARK 465     GLY Z   115                                                      
REMARK 465     GLY Z   116                                                      
REMARK 465     ASP Z   117                                                      
REMARK 465     ALA Z   118                                                      
REMARK 465     PRO Z   119                                                      
REMARK 465     ALA Z   120                                                      
REMARK 465     ALA Z   121                                                      
REMARK 465     GLY Z   122                                                      
REMARK 465     GLU Z   123                                                      
REMARK 465     ASP Z   124                                                      
REMARK 465     ALA Z   125                                                      
REMARK 465     MET c     1                                                      
REMARK 465     ASP c     2                                                      
REMARK 465     THR c     3                                                      
REMARK 465     SER c     4                                                      
REMARK 465     ARG c     5                                                      
REMARK 465     VAL c     6                                                      
REMARK 465     GLN c     7                                                      
REMARK 465     ARG c    69                                                      
REMARK 465     MET f     1                                                      
REMARK 465     GLN f     2                                                      
REMARK 465     ILE f     3                                                      
REMARK 465     PHE f     4                                                      
REMARK 465     VAL f     5                                                      
REMARK 465     LYS f     6                                                      
REMARK 465     THR f     7                                                      
REMARK 465     LEU f     8                                                      
REMARK 465     THR f     9                                                      
REMARK 465     GLY f    10                                                      
REMARK 465     LYS f    11                                                      
REMARK 465     THR f    12                                                      
REMARK 465     ILE f    13                                                      
REMARK 465     THR f    14                                                      
REMARK 465     LEU f    15                                                      
REMARK 465     GLU f    16                                                      
REMARK 465     VAL f    17                                                      
REMARK 465     GLU f    18                                                      
REMARK 465     PRO f    19                                                      
REMARK 465     SER f    20                                                      
REMARK 465     ASP f    21                                                      
REMARK 465     THR f    22                                                      
REMARK 465     ILE f    23                                                      
REMARK 465     GLU f    24                                                      
REMARK 465     ASN f    25                                                      
REMARK 465     VAL f    26                                                      
REMARK 465     LYS f    27                                                      
REMARK 465     ALA f    28                                                      
REMARK 465     LYS f    29                                                      
REMARK 465     ILE f    30                                                      
REMARK 465     GLN f    31                                                      
REMARK 465     ASP f    32                                                      
REMARK 465     LYS f    33                                                      
REMARK 465     GLU f    34                                                      
REMARK 465     GLY f    35                                                      
REMARK 465     ILE f    36                                                      
REMARK 465     PRO f    37                                                      
REMARK 465     PRO f    38                                                      
REMARK 465     ASP f    39                                                      
REMARK 465     GLN f    40                                                      
REMARK 465     GLN f    41                                                      
REMARK 465     ARG f    42                                                      
REMARK 465     LEU f    43                                                      
REMARK 465     ILE f    44                                                      
REMARK 465     PHE f    45                                                      
REMARK 465     ALA f    46                                                      
REMARK 465     GLY f    47                                                      
REMARK 465     LYS f    48                                                      
REMARK 465     GLN f    49                                                      
REMARK 465     LEU f    50                                                      
REMARK 465     GLU f    51                                                      
REMARK 465     ASP f    52                                                      
REMARK 465     GLY f    53                                                      
REMARK 465     ARG f    54                                                      
REMARK 465     THR f    55                                                      
REMARK 465     LEU f    56                                                      
REMARK 465     SER f    57                                                      
REMARK 465     ASP f    58                                                      
REMARK 465     TYR f    59                                                      
REMARK 465     ASN f    60                                                      
REMARK 465     ILE f    61                                                      
REMARK 465     GLN f    62                                                      
REMARK 465     LYS f    63                                                      
REMARK 465     GLU f    64                                                      
REMARK 465     SER f    65                                                      
REMARK 465     THR f    66                                                      
REMARK 465     LEU f    67                                                      
REMARK 465     HIS f    68                                                      
REMARK 465     LEU f    69                                                      
REMARK 465     VAL f    70                                                      
REMARK 465     LEU f    71                                                      
REMARK 465     ARG f    72                                                      
REMARK 465     LEU f    73                                                      
REMARK 465     ARG f    74                                                      
REMARK 465     GLY f    75                                                      
REMARK 465     GLY f    76                                                      
REMARK 465     ALA f    77                                                      
REMARK 465     PHE f   150                                                      
REMARK 465     ASN f   151                                                      
REMARK 465     LYS f   152                                                      
REMARK 465     PRO f   153                                                      
REMARK 465     GLU f   154                                                      
REMARK 465     ASP f   155                                                      
REMARK 465     LYS f   156                                                      
REMARK 465     MET g     1                                                      
REMARK 465     THR g   316                                                      
REMARK 465     ARG g   317                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU C  79    CG   CD   OE1  OE2                                  
REMARK 470     GLU C  80    CG   CD   OE1  OE2                                  
REMARK 470     GLU O  51    CG   CD   OE1  OE2                                  
REMARK 470     GLU D  23    CG   CD   OE1  OE2                                  
REMARK 470     THR R  55    OG1  CG2                                            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   NZ   LYS B    63     O    GLU B    89              1.51            
REMARK 500   NE1  TRP d     8     CB   HIS K    28              2.05            
REMARK 500   N2     G 2  1606     N7     A 2  1633              2.16            
REMARK 500   O    LYS B    63     CG2  THR B    88              2.16            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500      A 2  25   O4' -  C1' -  N9  ANGL. DEV. =   4.6 DEGREES          
REMARK 500      U 2  36   N1  -  C1' -  C2' ANGL. DEV. = -10.6 DEGREES          
REMARK 500      C 2  37   C4' -  C3' -  O3' ANGL. DEV. =  13.4 DEGREES          
REMARK 500      C 2  37   N1  -  C1' -  C2' ANGL. DEV. =  -9.8 DEGREES          
REMARK 500      A 2  38   N9  -  C1' -  C2' ANGL. DEV. =  -9.6 DEGREES          
REMARK 500      A 2  61   N9  -  C1' -  C2' ANGL. DEV. =  -7.4 DEGREES          
REMARK 500      G 2  80   C4  -  N9  -  C1' ANGL. DEV. =   7.8 DEGREES          
REMARK 500      A 2 102   C3' -  O3' -  P   ANGL. DEV. =   7.7 DEGREES          
REMARK 500      G 2 114   C3' -  O3' -  P   ANGL. DEV. =   7.4 DEGREES          
REMARK 500      G 2 130   C8  -  N9  -  C1' ANGL. DEV. =  -8.5 DEGREES          
REMARK 500      G 2 130   C4  -  N9  -  C1' ANGL. DEV. =  10.1 DEGREES          
REMARK 500      U 2 143   C3' -  O3' -  P   ANGL. DEV. =   7.6 DEGREES          
REMARK 500      C 2 179   C2  -  N1  -  C1' ANGL. DEV. =   6.7 DEGREES          
REMARK 500      G 2 180   C4  -  N9  -  C1' ANGL. DEV. =   8.2 DEGREES          
REMARK 500      C 2 182   C6  -  N1  -  C1' ANGL. DEV. =  -8.2 DEGREES          
REMARK 500      C 2 182   C2  -  N1  -  C1' ANGL. DEV. =   8.2 DEGREES          
REMARK 500      C 2 188   C2  -  N1  -  C1' ANGL. DEV. =   6.8 DEGREES          
REMARK 500      G 2 213   C4  -  N9  -  C1' ANGL. DEV. =   8.5 DEGREES          
REMARK 500      G 2 215   C4  -  N9  -  C1' ANGL. DEV. =   8.5 DEGREES          
REMARK 500      C 2 293   C2  -  N1  -  C1' ANGL. DEV. =   7.0 DEGREES          
REMARK 500      G 2 309   O4' -  C1' -  N9  ANGL. DEV. =   4.5 DEGREES          
REMARK 500      G 2 338   C4  -  N9  -  C1' ANGL. DEV. =   8.2 DEGREES          
REMARK 500      C 2 356   C6  -  N1  -  C1' ANGL. DEV. = -10.6 DEGREES          
REMARK 500      C 2 356   C2  -  N1  -  C1' ANGL. DEV. =  10.6 DEGREES          
REMARK 500      C 2 369   C6  -  N1  -  C1' ANGL. DEV. =  -8.4 DEGREES          
REMARK 500      C 2 369   C2  -  N1  -  C1' ANGL. DEV. =   8.5 DEGREES          
REMARK 500      G 2 383   C8  -  N9  -  C1' ANGL. DEV. =   8.7 DEGREES          
REMARK 500      U 2 427   O4' -  C1' -  N1  ANGL. DEV. =   4.3 DEGREES          
REMARK 500      C 2 430   C2  -  N1  -  C1' ANGL. DEV. =   7.2 DEGREES          
REMARK 500      C 2 441   C6  -  N1  -  C1' ANGL. DEV. =  -7.2 DEGREES          
REMARK 500      C 2 441   C2  -  N1  -  C1' ANGL. DEV. =   7.3 DEGREES          
REMARK 500      C 2 459   C2  -  N1  -  C1' ANGL. DEV. =   6.9 DEGREES          
REMARK 500      G 2 474   C4  -  N9  -  C1' ANGL. DEV. =   8.1 DEGREES          
REMARK 500      C 2 491   C2  -  N1  -  C1' ANGL. DEV. =   6.7 DEGREES          
REMARK 500      C 2 501   C6  -  N1  -  C1' ANGL. DEV. =  -8.5 DEGREES          
REMARK 500      C 2 501   C2  -  N1  -  C1' ANGL. DEV. =   8.6 DEGREES          
REMARK 500      C 2 532   C6  -  N1  -  C1' ANGL. DEV. =  -8.7 DEGREES          
REMARK 500      C 2 532   C2  -  N1  -  C1' ANGL. DEV. =   8.7 DEGREES          
REMARK 500      G 2 547   C3' -  O3' -  P   ANGL. DEV. =   8.5 DEGREES          
REMARK 500      C 2 568   N1  -  C2  -  O2  ANGL. DEV. =   3.7 DEGREES          
REMARK 500      C 2 570   N3  -  C2  -  O2  ANGL. DEV. =  -4.3 DEGREES          
REMARK 500      U 2 571   N3  -  C2  -  O2  ANGL. DEV. =  -4.7 DEGREES          
REMARK 500      C 2 578   C6  -  N1  -  C2  ANGL. DEV. =  -2.4 DEGREES          
REMARK 500      A 2 590   C8  -  N9  -  C1' ANGL. DEV. = -10.9 DEGREES          
REMARK 500      A 2 590   C4  -  N9  -  C1' ANGL. DEV. =  11.1 DEGREES          
REMARK 500      U 2 591   O4' -  C1' -  N1  ANGL. DEV. =   7.2 DEGREES          
REMARK 500      C 2 608   C5  -  C6  -  N1  ANGL. DEV. =   3.4 DEGREES          
REMARK 500      C 2 608   N1  -  C2  -  O2  ANGL. DEV. =   4.1 DEGREES          
REMARK 500      C 2 608   C2  -  N1  -  C1' ANGL. DEV. =   8.5 DEGREES          
REMARK 500      C 2 618   O5' -  P   -  OP1 ANGL. DEV. =  -6.1 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     257 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    TYR A  39      -64.80   -100.89                                   
REMARK 500    PRO A 119     -169.55    -74.90                                   
REMARK 500    THR A 188     -159.52    -81.95                                   
REMARK 500    PHE B  39     -169.42   -104.28                                   
REMARK 500    GLU B  89      -50.61   -125.20                                   
REMARK 500    HIS B 101      -55.88   -122.63                                   
REMARK 500    ASP B 104     -164.02   -160.25                                   
REMARK 500    ILE B 204      -62.23    -94.69                                   
REMARK 500    PHE B 211     -168.54   -126.45                                   
REMARK 500    LEU C 107      -60.25    -96.97                                   
REMARK 500    LYS C 114     -178.60    -65.42                                   
REMARK 500    ARG C 123     -165.31   -123.67                                   
REMARK 500    SER C 161       58.50   -102.39                                   
REMARK 500    CYS C 182     -155.26   -132.53                                   
REMARK 500    ARG C 187      107.97   -162.94                                   
REMARK 500    ARG C 194       88.26   -150.99                                   
REMARK 500    PHE C 269       36.41    -98.22                                   
REMARK 500    ARG E  30       84.13     55.16                                   
REMARK 500    THR E  33      105.94    -58.24                                   
REMARK 500    TYR E  54      -72.00    -71.04                                   
REMARK 500    PRO E 116        1.94    -66.11                                   
REMARK 500    ALA E 119       21.02    -77.46                                   
REMARK 500    THR E 133       71.62     58.22                                   
REMARK 500    TYR E 149       75.10     55.65                                   
REMARK 500    THR E 170      -55.06   -121.38                                   
REMARK 500    PHE E 172      139.68   -171.36                                   
REMARK 500    ASN E 188       30.21    -92.77                                   
REMARK 500    ASN E 214       30.68    -97.68                                   
REMARK 500    PHE E 218     -167.39   -170.22                                   
REMARK 500    PHE E 226      105.92   -161.80                                   
REMARK 500    SER G  53      -61.09    -95.53                                   
REMARK 500    LEU G  68       34.90    -93.38                                   
REMARK 500    TYR G  84      144.55   -173.61                                   
REMARK 500    LEU G 133       75.95     60.79                                   
REMARK 500    LEU H  36       38.84    -99.70                                   
REMARK 500    THR H 110       50.32    -90.90                                   
REMARK 500    ARG H 120       70.47   -103.16                                   
REMARK 500    VAL I  48     -167.89   -127.64                                   
REMARK 500    THR I  73      118.54   -164.44                                   
REMARK 500    ILE I  79      -62.84    -95.94                                   
REMARK 500    ASN I 138       44.64   -103.38                                   
REMARK 500    CYS I 174      104.18   -164.21                                   
REMARK 500    ALA J   4       34.88    -97.00                                   
REMARK 500    LYS J  91       32.13    -92.75                                   
REMARK 500    MET J  92       37.57    -92.67                                   
REMARK 500    ARG J 138      -37.54     70.35                                   
REMARK 500    LYS J 139      -16.27   -151.43                                   
REMARK 500    ASP J 158     -169.37   -109.02                                   
REMARK 500    SER J 160       79.52     58.80                                   
REMARK 500    LEU J 161        1.85    -48.25                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     130 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ILE I  101     VAL I  102                 -141.83                    
REMARK 500 HIS N  101     LEU N  102                 -148.95                    
REMARK 500 LEU O   93     HIS O   94                  148.88                    
REMARK 500 VAL X  112     GLY X  113                 -145.83                    
REMARK 500 ARG Y  118     GLY Y  119                 -143.97                    
REMARK 500 THR b   52     VAL b   53                 -145.73                    
REMARK 500 PRO D  194     THR D  195                 -142.37                    
REMARK 500 ALA F   40     VAL F   41                 -128.78                    
REMARK 500 MET F   77     MET F   78                 -144.55                    
REMARK 500 ASN F   82     ASN F   83                 -147.64                    
REMARK 500 ASN F  165     ILE F  166                 -125.06                    
REMARK 500 ILE Q   42     GLU Q   43                 -126.35                    
REMARK 500 THR T   36     VAL T   37                 -144.81                    
REMARK 500 THR f   87     PRO f   88                 -131.39                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN a 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS a  26   N                                                      
REMARK 620 2 CYS a  26   SG   88.3                                              
REMARK 620 3 CYS a  74   SG  135.4  91.8                                        
REMARK 620 4 CYS a  77   SG  109.9  89.4 114.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN d 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS d  21   SG                                                     
REMARK 620 2 CYS d  24   SG  104.4                                              
REMARK 620 3 CYS d  42   SG  122.7  91.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN f 500  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS f 126   SG                                                     
REMARK 620 2 CYS f 141   SG  103.5                                              
REMARK 620 3 CYS f 144   N   132.6 102.3                                        
REMARK 620 N                    1     2                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN a 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN d 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN f 500                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-4352   RELATED DB: EMDB                              
REMARK 900 CRYO-EM STRUCTURE OF A LATE HUMAN PRE-40S RIBOSOMAL SUBUNIT - MATURE 
DBREF  6G5H 2    1  1869  GB     337376   M10098.1       102   1969             
DBREF  6G5H A    1   295  UNP    P08865   RSSA_HUMAN       1    295             
DBREF  6G5H B    1   264  UNP    P61247   RS3A_HUMAN       1    264             
DBREF  6G5H C    1   293  UNP    P15880   RS2_HUMAN        1    293             
DBREF  6G5H E    1   263  UNP    P62701   RS4X_HUMAN       1    263             
DBREF  6G5H G    1   249  UNP    P62753   RS6_HUMAN        1    249             
DBREF  6G5H H    1   194  UNP    P62081   RS7_HUMAN        1    194             
DBREF  6G5H I    1   208  UNP    P62241   RS8_HUMAN        1    208             
DBREF  6G5H J    1   194  UNP    P46781   RS9_HUMAN        1    194             
DBREF  6G5H L    1   158  UNP    P62280   RS11_HUMAN       1    158             
DBREF  6G5H N    1   151  UNP    P62277   RS13_HUMAN       1    151             
DBREF  6G5H O    1   151  UNP    P62263   RS14_HUMAN       1    151             
DBREF  6G5H V    1    83  UNP    P63220   RS21_HUMAN       1     83             
DBREF  6G5H W    1   130  UNP    P62244   RS15A_HUMAN      1    130             
DBREF  6G5H X    1   143  UNP    P62266   RS23_HUMAN       1    143             
DBREF  6G5H Y    1   133  UNP    P62847   RS24_HUMAN       1    133             
DBREF  6G5H a    1   115  UNP    P62854   RS26_HUMAN       1    115             
DBREF  6G5H b    1    84  UNP    P42677   RS27_HUMAN       1     84             
DBREF  6G5H d    1    56  UNP    P62273   RS29_HUMAN       1     56             
DBREF  6G5H e    1    59  UNP    P62861   RS30_HUMAN       1     59             
DBREF  6G5H h    1    25  UNP    P62945   RL41_HUMAN       1     25             
DBREF  6G5H D    1   243  UNP    P23396   RS3_HUMAN        1    243             
DBREF  6G5H F    1   204  UNP    P46782   RS5_HUMAN        1    204             
DBREF  6G5H K    1   165  UNP    P46783   RS10_HUMAN       1    165             
DBREF  6G5H M    1   132  UNP    P25398   RS12_HUMAN       1    132             
DBREF  6G5H P    1   145  UNP    P62841   RS15_HUMAN       1    145             
DBREF  6G5H Q    1   146  UNP    P62249   RS16_HUMAN       1    146             
DBREF  6G5H R    1   135  UNP    P08708   RS17_HUMAN       1    135             
DBREF  6G5H S    1   152  UNP    P62269   RS18_HUMAN       1    152             
DBREF  6G5H T    1   145  UNP    P39019   RS19_HUMAN       1    145             
DBREF  6G5H U    1   119  UNP    P60866   RS20_HUMAN       1    119             
DBREF  6G5H Z    1   125  UNP    P62851   RS25_HUMAN       1    125             
DBREF  6G5H c    1    69  UNP    P62857   RS28_HUMAN       1     69             
DBREF  6G5H f    1   156  UNP    Q5RKT7   Q5RKT7_HUMAN     1    156             
DBREF  6G5H g    1   317  UNP    P63244   RACK1_HUMAN      1    317             
SEQADV 6G5H   C 2 1772  GB   337376      G  1872 CONFLICT                       
SEQRES   1 2 1868    U   A   C   C   U   G   G   U   U   G   A   U   C          
SEQRES   2 2 1868    C   U   G   C   C   A   G   U   A   G   C   A   U          
SEQRES   3 2 1868    A   U   G   C   U   U   G   U   C   U   C   A   A          
SEQRES   4 2 1868    A   G   A   U   U   A   A   G   C   C   A   U   G          
SEQRES   5 2 1868    C   A   U   G   U   C   U   A   A   G   U   A   C          
SEQRES   6 2 1868    G   C   A   C   G   G   C   C   G   G   U   A   C          
SEQRES   7 2 1868    A   G   U   G   A   A   A   C   U   G   C   G   A          
SEQRES   8 2 1868    A   U   G   G   C   U   C   A   U   U   A   A   A          
SEQRES   9 2 1868    U   C   A   G   U   U   A   U   G   G   U   U   C          
SEQRES  10 2 1868    C   U   U   U   G   G   U   C   G   C   U   C   G          
SEQRES  11 2 1868    C   U   C   C   U   C   U   C   C   U   A   C   U          
SEQRES  12 2 1868    U   G   G   A   U   A   A   C   U   G   U   G   G          
SEQRES  13 2 1868    U   A   A   U   U   C   U   A   G   A   G   C   U          
SEQRES  14 2 1868    A   A   U   A   C   A   U   G   C   C   G   A   C          
SEQRES  15 2 1868    G   G   G   C   G   C   U   G   A   C   C   C   C          
SEQRES  16 2 1868    C   U   U   C   G   C   G   G   G   G   G   G   G          
SEQRES  17 2 1868    A   U   G   C   G   U   G   C   A   U   U   U   A          
SEQRES  18 2 1868    U   C   A   G   A   U   C   A   A   A   A   C   C          
SEQRES  19 2 1868    A   A   C   C   C   G   G   U   C   A   G   C   C          
SEQRES  20 2 1868    C   C   U   C   U   C   C   G   G   C   C   C   C          
SEQRES  21 2 1868    G   G   C   C   G   G   G   G   G   G   C   G   G          
SEQRES  22 2 1868    G   C   C   G   C   G   G   C   G   G   C   U   U          
SEQRES  23 2 1868    U   G   G   U   G   A   C   U   C   U   A   G   A          
SEQRES  24 2 1868    U   A   A   C   C   U   C   G   G   G   C   C   G          
SEQRES  25 2 1868    A   U   C   G   C   A   C   G   C   C   C   C   C          
SEQRES  26 2 1868    C   G   U   G   G   C   G   G   C   G   A   C   G          
SEQRES  27 2 1868    A   C   C   C   A   U   U   C   G   A   A   C   G          
SEQRES  28 2 1868    U   C   U   G   C   C   C   U   A   U   C   A   A          
SEQRES  29 2 1868    C   U   U   U   C   G   A   U   G   G   U   A   G          
SEQRES  30 2 1868    U   C   G   C   C   G   U   G   C   C   U   A   C          
SEQRES  31 2 1868    C   A   U   G   G   U   G   A   C   C   A   C   G          
SEQRES  32 2 1868    G   G   U   G   A   C   G   G   G   G   A   A   U          
SEQRES  33 2 1868    C   A   G   G   G   U   U   C   G   A   U   U   C          
SEQRES  34 2 1868    C   G   G   A   G   A   G   G   G   A   G   C   C          
SEQRES  35 2 1868    U   G   A   G   A   A   A   C   G   G   C   U   A          
SEQRES  36 2 1868    C   C   A   C   A   U   C   C   A   A   G   G   A          
SEQRES  37 2 1868    A   G   G   C   A   G   C   A   G   G   C   G   C          
SEQRES  38 2 1868    G   C   A   A   A   U   U   A   C   C   C   A   C          
SEQRES  39 2 1868    U   C   C   C   G   A   C   C   C   G   G   G   G          
SEQRES  40 2 1868    A   G   G   U   A   G   U   G   A   C   G   A   A          
SEQRES  41 2 1868    A   A   A   U   A   A   C   A   A   U   A   C   A          
SEQRES  42 2 1868    G   G   A   C   U   C   U   U   U   C   G   A   G          
SEQRES  43 2 1868    G   C   C   C   U   G   U   A   A   U   U   G   G          
SEQRES  44 2 1868    A   A   U   G   A   G   U   C   C   A   C   U   U          
SEQRES  45 2 1868    U   A   A   A   U   C   C   U   U   U   A   A   C          
SEQRES  46 2 1868    G   A   G   G   A   U   C   C   A   U   U   G   G          
SEQRES  47 2 1868    A   G   G   G   C   A   A   G   U   C   U   G   G          
SEQRES  48 2 1868    U   G   C   C   A   G   C   A   G   C   C   G   C          
SEQRES  49 2 1868    G   G   U   A   A   U   U   C   C   A   G   C   U          
SEQRES  50 2 1868    C   C   A   A   U   A   G   C   G   U   A   U   A          
SEQRES  51 2 1868    U   U   A   A   A   G   U   U   G   C   U   G   C          
SEQRES  52 2 1868    A   G   U   U   A   A   A   A   A   G   C   U   C          
SEQRES  53 2 1868    G   U   A   G   U   U   G   G   A   U   C   U   U          
SEQRES  54 2 1868    G   G   G   A   G   C   G   G   G   C   G   G   G          
SEQRES  55 2 1868    C   G   G   U   C   C   G   C   C   G   C   G   A          
SEQRES  56 2 1868    G   G   C   G   A   G   C   C   A   C   C   G   C          
SEQRES  57 2 1868    C   C   G   U   C   C   C   C   G   C   C   C   C          
SEQRES  58 2 1868    U   U   G   C   C   U   C   U   C   G   G   C   G          
SEQRES  59 2 1868    C   C   C   C   C   U   C   G   A   U   G   C   U          
SEQRES  60 2 1868    C   U   U   A   G   C   U   G   A   G   U   G   U          
SEQRES  61 2 1868    C   C   C   G   C   G   G   G   G   C   C   C   G          
SEQRES  62 2 1868    A   A   G   C   G   U   U   U   A   C   U   U   U          
SEQRES  63 2 1868    G   A   A   A   A   A   A   U   U   A   G   A   G          
SEQRES  64 2 1868    U   G   U   U   C   A   A   A   G   C   A   G   G          
SEQRES  65 2 1868    C   C   C   G   A   G   C   C   G   C   C   U   G          
SEQRES  66 2 1868    G   A   U   A   C   C   G   C   A   G   C   U   A          
SEQRES  67 2 1868    G   G   A   A   U   A   A   U   G   G   A   A   U          
SEQRES  68 2 1868    A   G   G   A   C   C   G   C   G   G   U   U   C          
SEQRES  69 2 1868    U   A   U   U   U   U   G   U   U   G   G   U   U          
SEQRES  70 2 1868    U   U   C   G   G   A   A   C   U   G   A   G   G          
SEQRES  71 2 1868    C   C   A   U   G   A   U   U   A   A   G   A   G          
SEQRES  72 2 1868    G   G   A   C   G   G   C   C   G   G   G   G   G          
SEQRES  73 2 1868    C   A   U   U   C   G   U   A   U   U   G   C   G          
SEQRES  74 2 1868    C   C   G   C   U   A   G   A   G   G   U   G   A          
SEQRES  75 2 1868    A   A   U   U   C   U   U   G   G   A   C   C   G          
SEQRES  76 2 1868    G   C   G   C   A   A   G   A   C   G   G   A   C          
SEQRES  77 2 1868    C   A   G   A   G   C   G   A   A   A   G   C   A          
SEQRES  78 2 1868    U   U   U   G   C   C   A   A   G   A   A   U   G          
SEQRES  79 2 1868    U   U   U   U   C   A   U   U   A   A   U   C   A          
SEQRES  80 2 1868    A   G   A   A   C   G   A   A   A   G   U   C   G          
SEQRES  81 2 1868    G   A   G   G   U   U   C   G   A   A   G   A   C          
SEQRES  82 2 1868    G   A   U   C   A   G   A   U   A   C   C   G   U          
SEQRES  83 2 1868    C   G   U   A   G   U   U   C   C   G   A   C   C          
SEQRES  84 2 1868    A   U   A   A   A   C   G   A   U   G   C   C   G          
SEQRES  85 2 1868    A   C   C   G   G   C   G   A   U   G   C   G   G          
SEQRES  86 2 1868    C   G   G   C   G   U   U   A   U   U   C   C   C          
SEQRES  87 2 1868    A   U   G   A   C   C   C   G   C   C   G   G   G          
SEQRES  88 2 1868    C   A   G   C   U   U   C   C   G   G   G   A   A          
SEQRES  89 2 1868    A   C   C   A   A   A   G   U   C   U   U   U   G          
SEQRES  90 2 1868    G   G   U   U   C   C   G   G   G   G   G   G   A          
SEQRES  91 2 1868    G   U   A   U   G   G   U   U   G   C   A   A   A          
SEQRES  92 2 1868    G   C   U   G   A   A   A   C   U   U   A   A   A          
SEQRES  93 2 1868    G   G   A   A   U   U   G   A   C   G   G   A   A          
SEQRES  94 2 1868    G   G   G   C   A   C   C   A   C   C   A   G   G          
SEQRES  95 2 1868    A   G   U   G   G   A   G   C   C   U   G   C   G          
SEQRES  96 2 1868    G   C   U   U   A   A   U   U   U   G   A   C   U          
SEQRES  97 2 1868    C   A   A   C   A   C   G   G   G   A   A   A   C          
SEQRES  98 2 1868    C   U   C   A   C   C   C   G   G   C   C   C   G          
SEQRES  99 2 1868    G   A   C   A   C   G   G   A   C   A   G   G   A          
SEQRES 100 2 1868    U   U   G   A   C   A   G   A   U   U   G   A   U          
SEQRES 101 2 1868    A   G   C   U   C   U   U   U   C   U   C   G   A          
SEQRES 102 2 1868    U   U   C   C   G   U   G   G   G   U   G   G   U          
SEQRES 103 2 1868    G   G   U   G   C   A   U   G   G   C   C   G   U          
SEQRES 104 2 1868    U   C   U   U   A   G   U   U   G   G   U   G   G          
SEQRES 105 2 1868    A   G   C   G   A   U   U   U   G   U   C   U   G          
SEQRES 106 2 1868    G   U   U   A   A   U   U   C   C   G   A   U   A          
SEQRES 107 2 1868    A   C   G   A   A   C   G   A   G   A   C   U   C          
SEQRES 108 2 1868    U   G   G   C   A   U   G   C   U   A   A   C   U          
SEQRES 109 2 1868    A   G   U   U   A   C   G   C   G   A   C   C   C          
SEQRES 110 2 1868    C   C   G   A   G   C   G   G   U   C   G   G   C          
SEQRES 111 2 1868    G   U   C   C   C   C   C   A   A   C   U   U   C          
SEQRES 112 2 1868    U   U   A   G   A   G   G   G   A   C   A   A   G          
SEQRES 113 2 1868    U   G   G   C   G   U   U   C   A   G   C   C   A          
SEQRES 114 2 1868    C   C   C   G   A   G   A   U   U   G   A   G   C          
SEQRES 115 2 1868    A   A   U   A   A   C   A   G   G   U   C   U   G          
SEQRES 116 2 1868    U   G   A   U   G   C   C   C   U   U   A   G   A          
SEQRES 117 2 1868    U   G   U   C   C   G   G   G   G   C   U   G   C          
SEQRES 118 2 1868    A   C   G   C   G   C   G   C   U   A   C   A   C          
SEQRES 119 2 1868    U   G   A   C   U   G   G   C   U   C   A   G   C          
SEQRES 120 2 1868    G   U   G   U   G   C   C   U   A   C   C   C   U          
SEQRES 121 2 1868    A   C   G   C   C   G   G   C   A   G   G   C   G          
SEQRES 122 2 1868    C   G   G   G   U   A   A   C   C   C   G   U   U          
SEQRES 123 2 1868    G   A   A   C   C   C   C   A   U   U   C   G   U          
SEQRES 124 2 1868    G   A   U   G   G   G   G   A   U   C   G   G   G          
SEQRES 125 2 1868    G   A   U   U   G   C   A   A   U   U   A   U   U          
SEQRES 126 2 1868    C   C   C   C   A   U   G   A   A   C   G   A   G          
SEQRES 127 2 1868    G   A   A   U   U   C   C   C   A   G   U   A   A          
SEQRES 128 2 1868    G   U   G   C   G   G   G   U   C   A   U   A   A          
SEQRES 129 2 1868    G   C   U   U   G   C   G   U   U   G   A   U   U          
SEQRES 130 2 1868    A   A   G   U   C   C   C   U   G   C   C   C   U          
SEQRES 131 2 1868    U   U   G   U   A   C   A   C   A   C   C   G   C          
SEQRES 132 2 1868    C   C   G   U   C   G   C   U   A   C   U   A   C          
SEQRES 133 2 1868    C   G   A   U   U   G   G   A   U   G   G   U   U          
SEQRES 134 2 1868    U   A   G   U   G   A   G   G   C   C   C   U   C          
SEQRES 135 2 1868    G   G   A   U   C   G   G   C   C   C   C   G   C          
SEQRES 136 2 1868    C   G   G   G   G   U   C   G   G   C   C   C   A          
SEQRES 137 2 1868    C   G   C   C   C   U   G   G   C   G   G   A   G          
SEQRES 138 2 1868    C   G   C   U   G   A   G   A   A   G   A   C   G          
SEQRES 139 2 1868    G   U   C   G   A   A   C   U   U   G   A   C   U          
SEQRES 140 2 1868    A   U   C   U   A   G   A   G   G   A   A   G   U          
SEQRES 141 2 1868    A   A   A   A   G   U   C   G   U   A   A   C   A          
SEQRES 142 2 1868    A   G   G   U   U   U   C   C   G   U   A   G   G          
SEQRES 143 2 1868    U   G   A   A   C   C   U   G   C   G   G   A   A          
SEQRES 144 2 1868    G   G   A   U   C   A   U   U   A                          
SEQRES   1 A  295  MET SER GLY ALA LEU ASP VAL LEU GLN MET LYS GLU GLU          
SEQRES   2 A  295  ASP VAL LEU LYS PHE LEU ALA ALA GLY THR HIS LEU GLY          
SEQRES   3 A  295  GLY THR ASN LEU ASP PHE GLN MET GLU GLN TYR ILE TYR          
SEQRES   4 A  295  LYS ARG LYS SER ASP GLY ILE TYR ILE ILE ASN LEU LYS          
SEQRES   5 A  295  ARG THR TRP GLU LYS LEU LEU LEU ALA ALA ARG ALA ILE          
SEQRES   6 A  295  VAL ALA ILE GLU ASN PRO ALA ASP VAL SER VAL ILE SER          
SEQRES   7 A  295  SER ARG ASN THR GLY GLN ARG ALA VAL LEU LYS PHE ALA          
SEQRES   8 A  295  ALA ALA THR GLY ALA THR PRO ILE ALA GLY ARG PHE THR          
SEQRES   9 A  295  PRO GLY THR PHE THR ASN GLN ILE GLN ALA ALA PHE ARG          
SEQRES  10 A  295  GLU PRO ARG LEU LEU VAL VAL THR ASP PRO ARG ALA ASP          
SEQRES  11 A  295  HIS GLN PRO LEU THR GLU ALA SER TYR VAL ASN LEU PRO          
SEQRES  12 A  295  THR ILE ALA LEU CYS ASN THR ASP SER PRO LEU ARG TYR          
SEQRES  13 A  295  VAL ASP ILE ALA ILE PRO CYS ASN ASN LYS GLY ALA HIS          
SEQRES  14 A  295  SER VAL GLY LEU MET TRP TRP MET LEU ALA ARG GLU VAL          
SEQRES  15 A  295  LEU ARG MET ARG GLY THR ILE SER ARG GLU HIS PRO TRP          
SEQRES  16 A  295  GLU VAL MET PRO ASP LEU TYR PHE TYR ARG ASP PRO GLU          
SEQRES  17 A  295  GLU ILE GLU LYS GLU GLU GLN ALA ALA ALA GLU LYS ALA          
SEQRES  18 A  295  VAL THR LYS GLU GLU PHE GLN GLY GLU TRP THR ALA PRO          
SEQRES  19 A  295  ALA PRO GLU PHE THR ALA THR GLN PRO GLU VAL ALA ASP          
SEQRES  20 A  295  TRP SER GLU GLY VAL GLN VAL PRO SER VAL PRO ILE GLN          
SEQRES  21 A  295  GLN PHE PRO THR GLU ASP TRP SER ALA GLN PRO ALA THR          
SEQRES  22 A  295  GLU ASP TRP SER ALA ALA PRO THR ALA GLN ALA THR GLU          
SEQRES  23 A  295  TRP VAL GLY ALA THR THR ASP TRP SER                          
SEQRES   1 B  264  MET ALA VAL GLY LYS ASN LYS ARG LEU THR LYS GLY GLY          
SEQRES   2 B  264  LYS LYS GLY ALA LYS LYS LYS VAL VAL ASP PRO PHE SER          
SEQRES   3 B  264  LYS LYS ASP TRP TYR ASP VAL LYS ALA PRO ALA MET PHE          
SEQRES   4 B  264  ASN ILE ARG ASN ILE GLY LYS THR LEU VAL THR ARG THR          
SEQRES   5 B  264  GLN GLY THR LYS ILE ALA SER ASP GLY LEU LYS GLY ARG          
SEQRES   6 B  264  VAL PHE GLU VAL SER LEU ALA ASP LEU GLN ASN ASP GLU          
SEQRES   7 B  264  VAL ALA PHE ARG LYS PHE LYS LEU ILE THR GLU ASP VAL          
SEQRES   8 B  264  GLN GLY LYS ASN CYS LEU THR ASN PHE HIS GLY MET ASP          
SEQRES   9 B  264  LEU THR ARG ASP LYS MET CYS SER MET VAL LYS LYS TRP          
SEQRES  10 B  264  GLN THR MET ILE GLU ALA HIS VAL ASP VAL LYS THR THR          
SEQRES  11 B  264  ASP GLY TYR LEU LEU ARG LEU PHE CYS VAL GLY PHE THR          
SEQRES  12 B  264  LYS LYS ARG ASN ASN GLN ILE ARG LYS THR SER TYR ALA          
SEQRES  13 B  264  GLN HIS GLN GLN VAL ARG GLN ILE ARG LYS LYS MET MET          
SEQRES  14 B  264  GLU ILE MET THR ARG GLU VAL GLN THR ASN ASP LEU LYS          
SEQRES  15 B  264  GLU VAL VAL ASN LYS LEU ILE PRO ASP SER ILE GLY LYS          
SEQRES  16 B  264  ASP ILE GLU LYS ALA CYS GLN SER ILE TYR PRO LEU HIS          
SEQRES  17 B  264  ASP VAL PHE VAL ARG LYS VAL LYS MET LEU LYS LYS PRO          
SEQRES  18 B  264  LYS PHE GLU LEU GLY LYS LEU MET GLU LEU HIS GLY GLU          
SEQRES  19 B  264  GLY SER SER SER GLY LYS ALA THR GLY ASP GLU THR GLY          
SEQRES  20 B  264  ALA LYS VAL GLU ARG ALA ASP GLY TYR GLU PRO PRO VAL          
SEQRES  21 B  264  GLN GLU SER VAL                                              
SEQRES   1 C  293  MET ALA ASP ASP ALA GLY ALA ALA GLY GLY PRO GLY GLY          
SEQRES   2 C  293  PRO GLY GLY PRO GLY MET GLY ASN ARG GLY GLY PHE ARG          
SEQRES   3 C  293  GLY GLY PHE GLY SER GLY ILE ARG GLY ARG GLY ARG GLY          
SEQRES   4 C  293  ARG GLY ARG GLY ARG GLY ARG GLY ARG GLY ALA ARG GLY          
SEQRES   5 C  293  GLY LYS ALA GLU ASP LYS GLU TRP MET PRO VAL THR LYS          
SEQRES   6 C  293  LEU GLY ARG LEU VAL LYS ASP MET LYS ILE LYS SER LEU          
SEQRES   7 C  293  GLU GLU ILE TYR LEU PHE SER LEU PRO ILE LYS GLU SER          
SEQRES   8 C  293  GLU ILE ILE ASP PHE PHE LEU GLY ALA SER LEU LYS ASP          
SEQRES   9 C  293  GLU VAL LEU LYS ILE MET PRO VAL GLN LYS GLN THR ARG          
SEQRES  10 C  293  ALA GLY GLN ARG THR ARG PHE LYS ALA PHE VAL ALA ILE          
SEQRES  11 C  293  GLY ASP TYR ASN GLY HIS VAL GLY LEU GLY VAL LYS CYS          
SEQRES  12 C  293  SER LYS GLU VAL ALA THR ALA ILE ARG GLY ALA ILE ILE          
SEQRES  13 C  293  LEU ALA LYS LEU SER ILE VAL PRO VAL ARG ARG GLY TYR          
SEQRES  14 C  293  TRP GLY ASN LYS ILE GLY LYS PRO HIS THR VAL PRO CYS          
SEQRES  15 C  293  LYS VAL THR GLY ARG CYS GLY SER VAL LEU VAL ARG LEU          
SEQRES  16 C  293  ILE PRO ALA PRO ARG GLY THR GLY ILE VAL SER ALA PRO          
SEQRES  17 C  293  VAL PRO LYS LYS LEU LEU MET MET ALA GLY ILE ASP ASP          
SEQRES  18 C  293  CYS TYR THR SER ALA ARG GLY CYS THR ALA THR LEU GLY          
SEQRES  19 C  293  ASN PHE ALA LYS ALA THR PHE ASP ALA ILE SER LYS THR          
SEQRES  20 C  293  TYR SER TYR LEU THR PRO ASP LEU TRP LYS GLU THR VAL          
SEQRES  21 C  293  PHE THR LYS SER PRO TYR GLN GLU PHE THR ASP HIS LEU          
SEQRES  22 C  293  VAL LYS THR HIS THR ARG VAL SER VAL GLN ARG THR GLN          
SEQRES  23 C  293  ALA PRO ALA VAL ALA THR THR                                  
SEQRES   1 E  263  MET ALA ARG GLY PRO LYS LYS HIS LEU LYS ARG VAL ALA          
SEQRES   2 E  263  ALA PRO LYS HIS TRP MET LEU ASP LYS LEU THR GLY VAL          
SEQRES   3 E  263  PHE ALA PRO ARG PRO SER THR GLY PRO HIS LYS LEU ARG          
SEQRES   4 E  263  GLU CYS LEU PRO LEU ILE ILE PHE LEU ARG ASN ARG LEU          
SEQRES   5 E  263  LYS TYR ALA LEU THR GLY ASP GLU VAL LYS LYS ILE CYS          
SEQRES   6 E  263  MET GLN ARG PHE ILE LYS ILE ASP GLY LYS VAL ARG THR          
SEQRES   7 E  263  ASP ILE THR TYR PRO ALA GLY PHE MET ASP VAL ILE SER          
SEQRES   8 E  263  ILE ASP LYS THR GLY GLU ASN PHE ARG LEU ILE TYR ASP          
SEQRES   9 E  263  THR LYS GLY ARG PHE ALA VAL HIS ARG ILE THR PRO GLU          
SEQRES  10 E  263  GLU ALA LYS TYR LYS LEU CYS LYS VAL ARG LYS ILE PHE          
SEQRES  11 E  263  VAL GLY THR LYS GLY ILE PRO HIS LEU VAL THR HIS ASP          
SEQRES  12 E  263  ALA ARG THR ILE ARG TYR PRO ASP PRO LEU ILE LYS VAL          
SEQRES  13 E  263  ASN ASP THR ILE GLN ILE ASP LEU GLU THR GLY LYS ILE          
SEQRES  14 E  263  THR ASP PHE ILE LYS PHE ASP THR GLY ASN LEU CYS MET          
SEQRES  15 E  263  VAL THR GLY GLY ALA ASN LEU GLY ARG ILE GLY VAL ILE          
SEQRES  16 E  263  THR ASN ARG GLU ARG HIS PRO GLY SER PHE ASP VAL VAL          
SEQRES  17 E  263  HIS VAL LYS ASP ALA ASN GLY ASN SER PHE ALA THR ARG          
SEQRES  18 E  263  LEU SER ASN ILE PHE VAL ILE GLY LYS GLY ASN LYS PRO          
SEQRES  19 E  263  TRP ILE SER LEU PRO ARG GLY LYS GLY ILE ARG LEU THR          
SEQRES  20 E  263  ILE ALA GLU GLU ARG ASP LYS ARG LEU ALA ALA LYS GLN          
SEQRES  21 E  263  SER SER GLY                                                  
SEQRES   1 G  249  MET LYS LEU ASN ILE SER PHE PRO ALA THR GLY CYS GLN          
SEQRES   2 G  249  LYS LEU ILE GLU VAL ASP ASP GLU ARG LYS LEU ARG THR          
SEQRES   3 G  249  PHE TYR GLU LYS ARG MET ALA THR GLU VAL ALA ALA ASP          
SEQRES   4 G  249  ALA LEU GLY GLU GLU TRP LYS GLY TYR VAL VAL ARG ILE          
SEQRES   5 G  249  SER GLY GLY ASN ASP LYS GLN GLY PHE PRO MET LYS GLN          
SEQRES   6 G  249  GLY VAL LEU THR HIS GLY ARG VAL ARG LEU LEU LEU SER          
SEQRES   7 G  249  LYS GLY HIS SER CYS TYR ARG PRO ARG ARG THR GLY GLU          
SEQRES   8 G  249  ARG LYS ARG LYS SER VAL ARG GLY CYS ILE VAL ASP ALA          
SEQRES   9 G  249  ASN LEU SER VAL LEU ASN LEU VAL ILE VAL LYS LYS GLY          
SEQRES  10 G  249  GLU LYS ASP ILE PRO GLY LEU THR ASP THR THR VAL PRO          
SEQRES  11 G  249  ARG ARG LEU GLY PRO LYS ARG ALA SER ARG ILE ARG LYS          
SEQRES  12 G  249  LEU PHE ASN LEU SER LYS GLU ASP ASP VAL ARG GLN TYR          
SEQRES  13 G  249  VAL VAL ARG LYS PRO LEU ASN LYS GLU GLY LYS LYS PRO          
SEQRES  14 G  249  ARG THR LYS ALA PRO LYS ILE GLN ARG LEU VAL THR PRO          
SEQRES  15 G  249  ARG VAL LEU GLN HIS LYS ARG ARG ARG ILE ALA LEU LYS          
SEQRES  16 G  249  LYS GLN ARG THR LYS LYS ASN LYS GLU GLU ALA ALA GLU          
SEQRES  17 G  249  TYR ALA LYS LEU LEU ALA LYS ARG MET LYS GLU ALA LYS          
SEQRES  18 G  249  GLU LYS ARG GLN GLU GLN ILE ALA LYS ARG ARG ARG LEU          
SEQRES  19 G  249  SER SER LEU ARG ALA SER THR SER LYS SER GLU SER SER          
SEQRES  20 G  249  GLN LYS                                                      
SEQRES   1 H  194  MET PHE SER SER SER ALA LYS ILE VAL LYS PRO ASN GLY          
SEQRES   2 H  194  GLU LYS PRO ASP GLU PHE GLU SER GLY ILE SER GLN ALA          
SEQRES   3 H  194  LEU LEU GLU LEU GLU MET ASN SER ASP LEU LYS ALA GLN          
SEQRES   4 H  194  LEU ARG GLU LEU ASN ILE THR ALA ALA LYS GLU ILE GLU          
SEQRES   5 H  194  VAL GLY GLY GLY ARG LYS ALA ILE ILE ILE PHE VAL PRO          
SEQRES   6 H  194  VAL PRO GLN LEU LYS SER PHE GLN LYS ILE GLN VAL ARG          
SEQRES   7 H  194  LEU VAL ARG GLU LEU GLU LYS LYS PHE SER GLY LYS HIS          
SEQRES   8 H  194  VAL VAL PHE ILE ALA GLN ARG ARG ILE LEU PRO LYS PRO          
SEQRES   9 H  194  THR ARG LYS SER ARG THR LYS ASN LYS GLN LYS ARG PRO          
SEQRES  10 H  194  ARG SER ARG THR LEU THR ALA VAL HIS ASP ALA ILE LEU          
SEQRES  11 H  194  GLU ASP LEU VAL PHE PRO SER GLU ILE VAL GLY LYS ARG          
SEQRES  12 H  194  ILE ARG VAL LYS LEU ASP GLY SER ARG LEU ILE LYS VAL          
SEQRES  13 H  194  HIS LEU ASP LYS ALA GLN GLN ASN ASN VAL GLU HIS LYS          
SEQRES  14 H  194  VAL GLU THR PHE SER GLY VAL TYR LYS LYS LEU THR GLY          
SEQRES  15 H  194  LYS ASP VAL ASN PHE GLU PHE PRO GLU PHE GLN LEU              
SEQRES   1 I  208  MET GLY ILE SER ARG ASP ASN TRP HIS LYS ARG ARG LYS          
SEQRES   2 I  208  THR GLY GLY LYS ARG LYS PRO TYR HIS LYS LYS ARG LYS          
SEQRES   3 I  208  TYR GLU LEU GLY ARG PRO ALA ALA ASN THR LYS ILE GLY          
SEQRES   4 I  208  PRO ARG ARG ILE HIS THR VAL ARG VAL ARG GLY GLY ASN          
SEQRES   5 I  208  LYS LYS TYR ARG ALA LEU ARG LEU ASP VAL GLY ASN PHE          
SEQRES   6 I  208  SER TRP GLY SER GLU CYS CYS THR ARG LYS THR ARG ILE          
SEQRES   7 I  208  ILE ASP VAL VAL TYR ASN ALA SER ASN ASN GLU LEU VAL          
SEQRES   8 I  208  ARG THR LYS THR LEU VAL LYS ASN CYS ILE VAL LEU ILE          
SEQRES   9 I  208  ASP SER THR PRO TYR ARG GLN TRP TYR GLU SER HIS TYR          
SEQRES  10 I  208  ALA LEU PRO LEU GLY ARG LYS LYS GLY ALA LYS LEU THR          
SEQRES  11 I  208  PRO GLU GLU GLU GLU ILE LEU ASN LYS LYS ARG SER LYS          
SEQRES  12 I  208  LYS ILE GLN LYS LYS TYR ASP GLU ARG LYS LYS ASN ALA          
SEQRES  13 I  208  LYS ILE SER SER LEU LEU GLU GLU GLN PHE GLN GLN GLY          
SEQRES  14 I  208  LYS LEU LEU ALA CYS ILE ALA SER ARG PRO GLY GLN CYS          
SEQRES  15 I  208  GLY ARG ALA ASP GLY TYR VAL LEU GLU GLY LYS GLU LEU          
SEQRES  16 I  208  GLU PHE TYR LEU ARG LYS ILE LYS ALA ARG LYS GLY LYS          
SEQRES   1 J  194  MET PRO VAL ALA ARG SER TRP VAL CYS ARG LYS THR TYR          
SEQRES   2 J  194  VAL THR PRO ARG ARG PRO PHE GLU LYS SER ARG LEU ASP          
SEQRES   3 J  194  GLN GLU LEU LYS LEU ILE GLY GLU TYR GLY LEU ARG ASN          
SEQRES   4 J  194  LYS ARG GLU VAL TRP ARG VAL LYS PHE THR LEU ALA LYS          
SEQRES   5 J  194  ILE ARG LYS ALA ALA ARG GLU LEU LEU THR LEU ASP GLU          
SEQRES   6 J  194  LYS ASP PRO ARG ARG LEU PHE GLU GLY ASN ALA LEU LEU          
SEQRES   7 J  194  ARG ARG LEU VAL ARG ILE GLY VAL LEU ASP GLU GLY LYS          
SEQRES   8 J  194  MET LYS LEU ASP TYR ILE LEU GLY LEU LYS ILE GLU ASP          
SEQRES   9 J  194  PHE LEU GLU ARG ARG LEU GLN THR GLN VAL PHE LYS LEU          
SEQRES  10 J  194  GLY LEU ALA LYS SER ILE HIS HIS ALA ARG VAL LEU ILE          
SEQRES  11 J  194  ARG GLN ARG HIS ILE ARG VAL ARG LYS GLN VAL VAL ASN          
SEQRES  12 J  194  ILE PRO SER PHE ILE VAL ARG LEU ASP SER GLN LYS HIS          
SEQRES  13 J  194  ILE ASP PHE SER LEU ARG SER PRO TYR GLY GLY GLY ARG          
SEQRES  14 J  194  PRO GLY ARG VAL LYS ARG LYS ASN ALA LYS LYS GLY GLN          
SEQRES  15 J  194  GLY GLY ALA GLY ALA GLY ASP ASP GLU GLU GLU ASP              
SEQRES   1 L  158  MET ALA ASP ILE GLN THR GLU ARG ALA TYR GLN LYS GLN          
SEQRES   2 L  158  PRO THR ILE PHE GLN ASN LYS LYS ARG VAL LEU LEU GLY          
SEQRES   3 L  158  GLU THR GLY LYS GLU LYS LEU PRO ARG TYR TYR LYS ASN          
SEQRES   4 L  158  ILE GLY LEU GLY PHE LYS THR PRO LYS GLU ALA ILE GLU          
SEQRES   5 L  158  GLY THR TYR ILE ASP LYS LYS CYS PRO PHE THR GLY ASN          
SEQRES   6 L  158  VAL SER ILE ARG GLY ARG ILE LEU SER GLY VAL VAL THR          
SEQRES   7 L  158  LYS MET LYS MET GLN ARG THR ILE VAL ILE ARG ARG ASP          
SEQRES   8 L  158  TYR LEU HIS TYR ILE ARG LYS TYR ASN ARG PHE GLU LYS          
SEQRES   9 L  158  ARG HIS LYS ASN MET SER VAL HIS LEU SER PRO CYS PHE          
SEQRES  10 L  158  ARG ASP VAL GLN ILE GLY ASP ILE VAL THR VAL GLY GLU          
SEQRES  11 L  158  CYS ARG PRO LEU SER LYS THR VAL ARG PHE ASN VAL LEU          
SEQRES  12 L  158  LYS VAL THR LYS ALA ALA GLY THR LYS LYS GLN PHE GLN          
SEQRES  13 L  158  LYS PHE                                                      
SEQRES   1 N  151  MET GLY ARG MET HIS ALA PRO GLY LYS GLY LEU SER GLN          
SEQRES   2 N  151  SER ALA LEU PRO TYR ARG ARG SER VAL PRO THR TRP LEU          
SEQRES   3 N  151  LYS LEU THR SER ASP ASP VAL LYS GLU GLN ILE TYR LYS          
SEQRES   4 N  151  LEU ALA LYS LYS GLY LEU THR PRO SER GLN ILE GLY VAL          
SEQRES   5 N  151  ILE LEU ARG ASP SER HIS GLY VAL ALA GLN VAL ARG PHE          
SEQRES   6 N  151  VAL THR GLY ASN LYS ILE LEU ARG ILE LEU LYS SER LYS          
SEQRES   7 N  151  GLY LEU ALA PRO ASP LEU PRO GLU ASP LEU TYR HIS LEU          
SEQRES   8 N  151  ILE LYS LYS ALA VAL ALA VAL ARG LYS HIS LEU GLU ARG          
SEQRES   9 N  151  ASN ARG LYS ASP LYS ASP ALA LYS PHE ARG LEU ILE LEU          
SEQRES  10 N  151  ILE GLU SER ARG ILE HIS ARG LEU ALA ARG TYR TYR LYS          
SEQRES  11 N  151  THR LYS ARG VAL LEU PRO PRO ASN TRP LYS TYR GLU SER          
SEQRES  12 N  151  SER THR ALA SER ALA LEU VAL ALA                              
SEQRES   1 O  151  MET ALA PRO ARG LYS GLY LYS GLU LYS LYS GLU GLU GLN          
SEQRES   2 O  151  VAL ILE SER LEU GLY PRO GLN VAL ALA GLU GLY GLU ASN          
SEQRES   3 O  151  VAL PHE GLY VAL CYS HIS ILE PHE ALA SER PHE ASN ASP          
SEQRES   4 O  151  THR PHE VAL HIS VAL THR ASP LEU SER GLY LYS GLU THR          
SEQRES   5 O  151  ILE CYS ARG VAL THR GLY GLY MET LYS VAL LYS ALA ASP          
SEQRES   6 O  151  ARG ASP GLU SER SER PRO TYR ALA ALA MET LEU ALA ALA          
SEQRES   7 O  151  GLN ASP VAL ALA GLN ARG CYS LYS GLU LEU GLY ILE THR          
SEQRES   8 O  151  ALA LEU HIS ILE LYS LEU ARG ALA THR GLY GLY ASN ARG          
SEQRES   9 O  151  THR LYS THR PRO GLY PRO GLY ALA GLN SER ALA LEU ARG          
SEQRES  10 O  151  ALA LEU ALA ARG SER GLY MET LYS ILE GLY ARG ILE GLU          
SEQRES  11 O  151  ASP VAL THR PRO ILE PRO SER ASP SER THR ARG ARG LYS          
SEQRES  12 O  151  GLY GLY ARG ARG GLY ARG ARG LEU                              
SEQRES   1 V   83  MET GLN ASN ASP ALA GLY GLU PHE VAL ASP LEU TYR VAL          
SEQRES   2 V   83  PRO ARG LYS CYS SER ALA SER ASN ARG ILE ILE GLY ALA          
SEQRES   3 V   83  LYS ASP HIS ALA SER ILE GLN MET ASN VAL ALA GLU VAL          
SEQRES   4 V   83  ASP LYS VAL THR GLY ARG PHE ASN GLY GLN PHE LYS THR          
SEQRES   5 V   83  TYR ALA ILE CYS GLY ALA ILE ARG ARG MET GLY GLU SER          
SEQRES   6 V   83  ASP ASP SER ILE LEU ARG LEU ALA LYS ALA ASP GLY ILE          
SEQRES   7 V   83  VAL SER LYS ASN PHE                                          
SEQRES   1 W  130  MET VAL ARG MET ASN VAL LEU ALA ASP ALA LEU LYS SER          
SEQRES   2 W  130  ILE ASN ASN ALA GLU LYS ARG GLY LYS ARG GLN VAL LEU          
SEQRES   3 W  130  ILE ARG PRO CYS SER LYS VAL ILE VAL ARG PHE LEU THR          
SEQRES   4 W  130  VAL MET MET LYS HIS GLY TYR ILE GLY GLU PHE GLU ILE          
SEQRES   5 W  130  ILE ASP ASP HIS ARG ALA GLY LYS ILE VAL VAL ASN LEU          
SEQRES   6 W  130  THR GLY ARG LEU ASN LYS CYS GLY VAL ILE SER PRO ARG          
SEQRES   7 W  130  PHE ASP VAL GLN LEU LYS ASP LEU GLU LYS TRP GLN ASN          
SEQRES   8 W  130  ASN LEU LEU PRO SER ARG GLN PHE GLY PHE ILE VAL LEU          
SEQRES   9 W  130  THR THR SER ALA GLY ILE MET ASP HIS GLU GLU ALA ARG          
SEQRES  10 W  130  ARG LYS HIS THR GLY GLY LYS ILE LEU GLY PHE PHE PHE          
SEQRES   1 X  143  MET GLY LYS CYS ARG GLY LEU ARG THR ALA ARG LYS LEU          
SEQRES   2 X  143  ARG SER HIS ARG ARG ASP GLN LYS TRP HIS ASP LYS GLN          
SEQRES   3 X  143  TYR LYS LYS ALA HIS LEU GLY THR ALA LEU LYS ALA ASN          
SEQRES   4 X  143  PRO PHE GLY GLY ALA SER HIS ALA LYS GLY ILE VAL LEU          
SEQRES   5 X  143  GLU LYS VAL GLY VAL GLU ALA LYS GLN PRO ASN SER ALA          
SEQRES   6 X  143  ILE ARG LYS CYS VAL ARG VAL GLN LEU ILE LYS ASN GLY          
SEQRES   7 X  143  LYS LYS ILE THR ALA PHE VAL PRO ASN ASP GLY CYS LEU          
SEQRES   8 X  143  ASN PHE ILE GLU GLU ASN ASP GLU VAL LEU VAL ALA GLY          
SEQRES   9 X  143  PHE GLY ARG LYS GLY HIS ALA VAL GLY ASP ILE PRO GLY          
SEQRES  10 X  143  VAL ARG PHE LYS VAL VAL LYS VAL ALA ASN VAL SER LEU          
SEQRES  11 X  143  LEU ALA LEU TYR LYS GLY LYS LYS GLU ARG PRO ARG SER          
SEQRES   1 Y  133  MET ASN ASP THR VAL THR ILE ARG THR ARG LYS PHE MET          
SEQRES   2 Y  133  THR ASN ARG LEU LEU GLN ARG LYS GLN MET VAL ILE ASP          
SEQRES   3 Y  133  VAL LEU HIS PRO GLY LYS ALA THR VAL PRO LYS THR GLU          
SEQRES   4 Y  133  ILE ARG GLU LYS LEU ALA LYS MET TYR LYS THR THR PRO          
SEQRES   5 Y  133  ASP VAL ILE PHE VAL PHE GLY PHE ARG THR HIS PHE GLY          
SEQRES   6 Y  133  GLY GLY LYS THR THR GLY PHE GLY MET ILE TYR ASP SER          
SEQRES   7 Y  133  LEU ASP TYR ALA LYS LYS ASN GLU PRO LYS HIS ARG LEU          
SEQRES   8 Y  133  ALA ARG HIS GLY LEU TYR GLU LYS LYS LYS THR SER ARG          
SEQRES   9 Y  133  LYS GLN ARG LYS GLU ARG LYS ASN ARG MET LYS LYS VAL          
SEQRES  10 Y  133  ARG GLY THR ALA LYS ALA ASN VAL GLY ALA GLY LYS LYS          
SEQRES  11 Y  133  PRO LYS GLU                                                  
SEQRES   1 a  115  MET THR LYS LYS ARG ARG ASN ASN GLY ARG ALA LYS LYS          
SEQRES   2 a  115  GLY ARG GLY HIS VAL GLN PRO ILE ARG CYS THR ASN CYS          
SEQRES   3 a  115  ALA ARG CYS VAL PRO LYS ASP LYS ALA ILE LYS LYS PHE          
SEQRES   4 a  115  VAL ILE ARG ASN ILE VAL GLU ALA ALA ALA VAL ARG ASP          
SEQRES   5 a  115  ILE SER GLU ALA SER VAL PHE ASP ALA TYR VAL LEU PRO          
SEQRES   6 a  115  LYS LEU TYR VAL LYS LEU HIS TYR CYS VAL SER CYS ALA          
SEQRES   7 a  115  ILE HIS SER LYS VAL VAL ARG ASN ARG SER ARG GLU ALA          
SEQRES   8 a  115  ARG LYS ASP ARG THR PRO PRO PRO ARG PHE ARG PRO ALA          
SEQRES   9 a  115  GLY ALA ALA PRO ARG PRO PRO PRO LYS PRO MET                  
SEQRES   1 b   84  MET PRO LEU ALA LYS ASP LEU LEU HIS PRO SER PRO GLU          
SEQRES   2 b   84  GLU GLU LYS ARG LYS HIS LYS LYS LYS ARG LEU VAL GLN          
SEQRES   3 b   84  SER PRO ASN SER TYR PHE MET ASP VAL LYS CYS PRO GLY          
SEQRES   4 b   84  CYS TYR LYS ILE THR THR VAL PHE SER HIS ALA GLN THR          
SEQRES   5 b   84  VAL VAL LEU CYS VAL GLY CYS SER THR VAL LEU CYS GLN          
SEQRES   6 b   84  PRO THR GLY GLY LYS ALA ARG LEU THR GLU GLY CYS SER          
SEQRES   7 b   84  PHE ARG ARG LYS GLN HIS                                      
SEQRES   1 d   56  MET GLY HIS GLN GLN LEU TYR TRP SER HIS PRO ARG LYS          
SEQRES   2 d   56  PHE GLY GLN GLY SER ARG SER CYS ARG VAL CYS SER ASN          
SEQRES   3 d   56  ARG HIS GLY LEU ILE ARG LYS TYR GLY LEU ASN MET CYS          
SEQRES   4 d   56  ARG GLN CYS PHE ARG GLN TYR ALA LYS ASP ILE GLY PHE          
SEQRES   5 d   56  ILE LYS LEU ASP                                              
SEQRES   1 e   59  LYS VAL HIS GLY SER LEU ALA ARG ALA GLY LYS VAL ARG          
SEQRES   2 e   59  GLY GLN THR PRO LYS VAL ALA LYS GLN GLU LYS LYS LYS          
SEQRES   3 e   59  LYS LYS THR GLY ARG ALA LYS ARG ARG MET GLN TYR ASN          
SEQRES   4 e   59  ARG ARG PHE VAL ASN VAL VAL PRO THR PHE GLY LYS LYS          
SEQRES   5 e   59  LYS GLY PRO ASN ALA ASN SER                                  
SEQRES   1 h   25  MET ARG ALA LYS TRP ARG LYS LYS ARG MET ARG ARG LEU          
SEQRES   2 h   25  LYS ARG LYS ARG ARG LYS MET ARG GLN ARG SER LYS              
SEQRES   1 D  243  MET ALA VAL GLN ILE SER LYS LYS ARG LYS PHE VAL ALA          
SEQRES   2 D  243  ASP GLY ILE PHE LYS ALA GLU LEU ASN GLU PHE LEU THR          
SEQRES   3 D  243  ARG GLU LEU ALA GLU ASP GLY TYR SER GLY VAL GLU VAL          
SEQRES   4 D  243  ARG VAL THR PRO THR ARG THR GLU ILE ILE ILE LEU ALA          
SEQRES   5 D  243  THR ARG THR GLN ASN VAL LEU GLY GLU LYS GLY ARG ARG          
SEQRES   6 D  243  ILE ARG GLU LEU THR ALA VAL VAL GLN LYS ARG PHE GLY          
SEQRES   7 D  243  PHE PRO GLU GLY SER VAL GLU LEU TYR ALA GLU LYS VAL          
SEQRES   8 D  243  ALA THR ARG GLY LEU CYS ALA ILE ALA GLN ALA GLU SER          
SEQRES   9 D  243  LEU ARG TYR LYS LEU LEU GLY GLY LEU ALA VAL ARG ARG          
SEQRES  10 D  243  ALA CYS TYR GLY VAL LEU ARG PHE ILE MET GLU SER GLY          
SEQRES  11 D  243  ALA LYS GLY CYS GLU VAL VAL VAL SER GLY LYS LEU ARG          
SEQRES  12 D  243  GLY GLN ARG ALA LYS SER MET LYS PHE VAL ASP GLY LEU          
SEQRES  13 D  243  MET ILE HIS SER GLY ASP PRO VAL ASN TYR TYR VAL ASP          
SEQRES  14 D  243  THR ALA VAL ARG HIS VAL LEU LEU ARG GLN GLY VAL LEU          
SEQRES  15 D  243  GLY ILE LYS VAL LYS ILE MET LEU PRO TRP ASP PRO THR          
SEQRES  16 D  243  GLY LYS ILE GLY PRO LYS LYS PRO LEU PRO ASP HIS VAL          
SEQRES  17 D  243  SER ILE VAL GLU PRO LYS ASP GLU ILE LEU PRO THR THR          
SEQRES  18 D  243  PRO ILE SER GLU GLN LYS GLY GLY LYS PRO GLU PRO PRO          
SEQRES  19 D  243  ALA MET PRO GLN PRO VAL PRO THR ALA                          
SEQRES   1 F  204  MET THR GLU TRP GLU THR ALA ALA PRO ALA VAL ALA GLU          
SEQRES   2 F  204  THR PRO ASP ILE LYS LEU PHE GLY LYS TRP SER THR ASP          
SEQRES   3 F  204  ASP VAL GLN ILE ASN ASP ILE SER LEU GLN ASP TYR ILE          
SEQRES   4 F  204  ALA VAL LYS GLU LYS TYR ALA LYS TYR LEU PRO HIS SER          
SEQRES   5 F  204  ALA GLY ARG TYR ALA ALA LYS ARG PHE ARG LYS ALA GLN          
SEQRES   6 F  204  CYS PRO ILE VAL GLU ARG LEU THR ASN SER MET MET MET          
SEQRES   7 F  204  HIS GLY ARG ASN ASN GLY LYS LYS LEU MET THR VAL ARG          
SEQRES   8 F  204  ILE VAL LYS HIS ALA PHE GLU ILE ILE HIS LEU LEU THR          
SEQRES   9 F  204  GLY GLU ASN PRO LEU GLN VAL LEU VAL ASN ALA ILE ILE          
SEQRES  10 F  204  ASN SER GLY PRO ARG GLU ASP SER THR ARG ILE GLY ARG          
SEQRES  11 F  204  ALA GLY THR VAL ARG ARG GLN ALA VAL ASP VAL SER PRO          
SEQRES  12 F  204  LEU ARG ARG VAL ASN GLN ALA ILE TRP LEU LEU CYS THR          
SEQRES  13 F  204  GLY ALA ARG GLU ALA ALA PHE ARG ASN ILE LYS THR ILE          
SEQRES  14 F  204  ALA GLU CYS LEU ALA ASP GLU LEU ILE ASN ALA ALA LYS          
SEQRES  15 F  204  GLY SER SER ASN SER TYR ALA ILE LYS LYS LYS ASP GLU          
SEQRES  16 F  204  LEU GLU ARG VAL ALA LYS SER ASN ARG                          
SEQRES   1 K  165  MET LEU MET PRO LYS LYS ASN ARG ILE ALA ILE TYR GLU          
SEQRES   2 K  165  LEU LEU PHE LYS GLU GLY VAL MET VAL ALA LYS LYS ASP          
SEQRES   3 K  165  VAL HIS MET PRO LYS HIS PRO GLU LEU ALA ASP LYS ASN          
SEQRES   4 K  165  VAL PRO ASN LEU HIS VAL MET LYS ALA MET GLN SER LEU          
SEQRES   5 K  165  LYS SER ARG GLY TYR VAL LYS GLU GLN PHE ALA TRP ARG          
SEQRES   6 K  165  HIS PHE TYR TRP TYR LEU THR ASN GLU GLY ILE GLN TYR          
SEQRES   7 K  165  LEU ARG ASP TYR LEU HIS LEU PRO PRO GLU ILE VAL PRO          
SEQRES   8 K  165  ALA THR LEU ARG ARG SER ARG PRO GLU THR GLY ARG PRO          
SEQRES   9 K  165  ARG PRO LYS GLY LEU GLU GLY GLU ARG PRO ALA ARG LEU          
SEQRES  10 K  165  THR ARG GLY GLU ALA ASP ARG ASP THR TYR ARG ARG SER          
SEQRES  11 K  165  ALA VAL PRO PRO GLY ALA ASP LYS LYS ALA GLU ALA GLY          
SEQRES  12 K  165  ALA GLY SER ALA THR GLU PHE GLN PHE ARG GLY GLY PHE          
SEQRES  13 K  165  GLY ARG GLY ARG GLY GLN PRO PRO GLN                          
SEQRES   1 M  132  MET ALA GLU GLU GLY ILE ALA ALA GLY GLY VAL MET ASP          
SEQRES   2 M  132  VAL ASN THR ALA LEU GLN GLU VAL LEU LYS THR ALA LEU          
SEQRES   3 M  132  ILE HIS ASP GLY LEU ALA ARG GLY ILE ARG GLU ALA ALA          
SEQRES   4 M  132  LYS ALA LEU ASP LYS ARG GLN ALA HIS LEU CYS VAL LEU          
SEQRES   5 M  132  ALA SER ASN CYS ASP GLU PRO MET TYR VAL LYS LEU VAL          
SEQRES   6 M  132  GLU ALA LEU CYS ALA GLU HIS GLN ILE ASN LEU ILE LYS          
SEQRES   7 M  132  VAL ASP ASP ASN LYS LYS LEU GLY GLU TRP VAL GLY LEU          
SEQRES   8 M  132  CYS LYS ILE ASP ARG GLU GLY LYS PRO ARG LYS VAL VAL          
SEQRES   9 M  132  GLY CYS SER CYS VAL VAL VAL LYS ASP TYR GLY LYS GLU          
SEQRES  10 M  132  SER GLN ALA LYS ASP VAL ILE GLU GLU TYR PHE LYS CYS          
SEQRES  11 M  132  LYS LYS                                                      
SEQRES   1 P  145  MET ALA GLU VAL GLU GLN LYS LYS LYS ARG THR PHE ARG          
SEQRES   2 P  145  LYS PHE THR TYR ARG GLY VAL ASP LEU ASP GLN LEU LEU          
SEQRES   3 P  145  ASP MET SER TYR GLU GLN LEU MET GLN LEU TYR SER ALA          
SEQRES   4 P  145  ARG GLN ARG ARG ARG LEU ASN ARG GLY LEU ARG ARG LYS          
SEQRES   5 P  145  GLN HIS SER LEU LEU LYS ARG LEU ARG LYS ALA LYS LYS          
SEQRES   6 P  145  GLU ALA PRO PRO MET GLU LYS PRO GLU VAL VAL LYS THR          
SEQRES   7 P  145  HIS LEU ARG ASP MET ILE ILE LEU PRO GLU MET VAL GLY          
SEQRES   8 P  145  SER MET VAL GLY VAL TYR ASN GLY LYS THR PHE ASN GLN          
SEQRES   9 P  145  VAL GLU ILE LYS PRO GLU MET ILE GLY HIS TYR LEU GLY          
SEQRES  10 P  145  GLU PHE SER ILE THR TYR LYS PRO VAL LYS HIS GLY ARG          
SEQRES  11 P  145  PRO GLY ILE GLY ALA THR HIS SER SER ARG PHE ILE PRO          
SEQRES  12 P  145  LEU LYS                                                      
SEQRES   1 Q  146  MET PRO SER LYS GLY PRO LEU GLN SER VAL GLN VAL PHE          
SEQRES   2 Q  146  GLY ARG LYS LYS THR ALA THR ALA VAL ALA HIS CYS LYS          
SEQRES   3 Q  146  ARG GLY ASN GLY LEU ILE LYS VAL ASN GLY ARG PRO LEU          
SEQRES   4 Q  146  GLU MET ILE GLU PRO ARG THR LEU GLN TYR LYS LEU LEU          
SEQRES   5 Q  146  GLU PRO VAL LEU LEU LEU GLY LYS GLU ARG PHE ALA GLY          
SEQRES   6 Q  146  VAL ASP ILE ARG VAL ARG VAL LYS GLY GLY GLY HIS VAL          
SEQRES   7 Q  146  ALA GLN ILE TYR ALA ILE ARG GLN SER ILE SER LYS ALA          
SEQRES   8 Q  146  LEU VAL ALA TYR TYR GLN LYS TYR VAL ASP GLU ALA SER          
SEQRES   9 Q  146  LYS LYS GLU ILE LYS ASP ILE LEU ILE GLN TYR ASP ARG          
SEQRES  10 Q  146  THR LEU LEU VAL ALA ASP PRO ARG ARG CYS GLU SER LYS          
SEQRES  11 Q  146  LYS PHE GLY GLY PRO GLY ALA ARG ALA ARG TYR GLN LYS          
SEQRES  12 Q  146  SER TYR ARG                                                  
SEQRES   1 R  135  MET GLY ARG VAL ARG THR LYS THR VAL LYS LYS ALA ALA          
SEQRES   2 R  135  ARG VAL ILE ILE GLU LYS TYR TYR THR ARG LEU GLY ASN          
SEQRES   3 R  135  ASP PHE HIS THR ASN LYS ARG VAL CYS GLU GLU ILE ALA          
SEQRES   4 R  135  ILE ILE PRO SER LYS LYS LEU ARG ASN LYS ILE ALA GLY          
SEQRES   5 R  135  TYR VAL THR HIS LEU MET LYS ARG ILE GLN ARG GLY PRO          
SEQRES   6 R  135  VAL ARG GLY ILE SER ILE LYS LEU GLN GLU GLU GLU ARG          
SEQRES   7 R  135  GLU ARG ARG ASP ASN TYR VAL PRO GLU VAL SER ALA LEU          
SEQRES   8 R  135  ASP GLN GLU ILE ILE GLU VAL ASP PRO ASP THR LYS GLU          
SEQRES   9 R  135  MET LEU LYS LEU LEU ASP PHE GLY SER LEU SER ASN LEU          
SEQRES  10 R  135  GLN VAL THR GLN PRO THR VAL GLY MET ASN PHE LYS THR          
SEQRES  11 R  135  PRO ARG GLY PRO VAL                                          
SEQRES   1 S  152  MET SER LEU VAL ILE PRO GLU LYS PHE GLN HIS ILE LEU          
SEQRES   2 S  152  ARG VAL LEU ASN THR ASN ILE ASP GLY ARG ARG LYS ILE          
SEQRES   3 S  152  ALA PHE ALA ILE THR ALA ILE LYS GLY VAL GLY ARG ARG          
SEQRES   4 S  152  TYR ALA HIS VAL VAL LEU ARG LYS ALA ASP ILE ASP LEU          
SEQRES   5 S  152  THR LYS ARG ALA GLY GLU LEU THR GLU ASP GLU VAL GLU          
SEQRES   6 S  152  ARG VAL ILE THR ILE MET GLN ASN PRO ARG GLN TYR LYS          
SEQRES   7 S  152  ILE PRO ASP TRP PHE LEU ASN ARG GLN LYS ASP VAL LYS          
SEQRES   8 S  152  ASP GLY LYS TYR SER GLN VAL LEU ALA ASN GLY LEU ASP          
SEQRES   9 S  152  ASN LYS LEU ARG GLU ASP LEU GLU ARG LEU LYS LYS ILE          
SEQRES  10 S  152  ARG ALA HIS ARG GLY LEU ARG HIS PHE TRP GLY LEU ARG          
SEQRES  11 S  152  VAL ARG GLY GLN HIS THR LYS THR THR GLY ARG ARG GLY          
SEQRES  12 S  152  ARG THR VAL GLY VAL SER LYS LYS LYS                          
SEQRES   1 T  145  MET PRO GLY VAL THR VAL LYS ASP VAL ASN GLN GLN GLU          
SEQRES   2 T  145  PHE VAL ARG ALA LEU ALA ALA PHE LEU LYS LYS SER GLY          
SEQRES   3 T  145  LYS LEU LYS VAL PRO GLU TRP VAL ASP THR VAL LYS LEU          
SEQRES   4 T  145  ALA LYS HIS LYS GLU LEU ALA PRO TYR ASP GLU ASN TRP          
SEQRES   5 T  145  PHE TYR THR ARG ALA ALA SER THR ALA ARG HIS LEU TYR          
SEQRES   6 T  145  LEU ARG GLY GLY ALA GLY VAL GLY SER MET THR LYS ILE          
SEQRES   7 T  145  TYR GLY GLY ARG GLN ARG ASN GLY VAL MET PRO SER HIS          
SEQRES   8 T  145  PHE SER ARG GLY SER LYS SER VAL ALA ARG ARG VAL LEU          
SEQRES   9 T  145  GLN ALA LEU GLU GLY LEU LYS MET VAL GLU LYS ASP GLN          
SEQRES  10 T  145  ASP GLY GLY ARG LYS LEU THR PRO GLN GLY GLN ARG ASP          
SEQRES  11 T  145  LEU ASP ARG ILE ALA GLY GLN VAL ALA ALA ALA ASN LYS          
SEQRES  12 T  145  LYS HIS                                                      
SEQRES   1 U  119  MET ALA PHE LYS ASP THR GLY LYS THR PRO VAL GLU PRO          
SEQRES   2 U  119  GLU VAL ALA ILE HIS ARG ILE ARG ILE THR LEU THR SER          
SEQRES   3 U  119  ARG ASN VAL LYS SER LEU GLU LYS VAL CYS ALA ASP LEU          
SEQRES   4 U  119  ILE ARG GLY ALA LYS GLU LYS ASN LEU LYS VAL LYS GLY          
SEQRES   5 U  119  PRO VAL ARG MET PRO THR LYS THR LEU ARG ILE THR THR          
SEQRES   6 U  119  ARG LYS THR PRO CYS GLY GLU GLY SER LYS THR TRP ASP          
SEQRES   7 U  119  ARG PHE GLN MET ARG ILE HIS LYS ARG LEU ILE ASP LEU          
SEQRES   8 U  119  HIS SER PRO SER GLU ILE VAL LYS GLN ILE THR SER ILE          
SEQRES   9 U  119  SER ILE GLU PRO GLY VAL GLU VAL GLU VAL THR ILE ALA          
SEQRES  10 U  119  ASP ALA                                                      
SEQRES   1 Z  125  MET PRO PRO LYS ASP ASP LYS LYS LYS LYS ASP ALA GLY          
SEQRES   2 Z  125  LYS SER ALA LYS LYS ASP LYS ASP PRO VAL ASN LYS SER          
SEQRES   3 Z  125  GLY GLY LYS ALA LYS LYS LYS LYS TRP SER LYS GLY LYS          
SEQRES   4 Z  125  VAL ARG ASP LYS LEU ASN ASN LEU VAL LEU PHE ASP LYS          
SEQRES   5 Z  125  ALA THR TYR ASP LYS LEU CYS LYS GLU VAL PRO ASN TYR          
SEQRES   6 Z  125  LYS LEU ILE THR PRO ALA VAL VAL SER GLU ARG LEU LYS          
SEQRES   7 Z  125  ILE ARG GLY SER LEU ALA ARG ALA ALA LEU GLN GLU LEU          
SEQRES   8 Z  125  LEU SER LYS GLY LEU ILE LYS LEU VAL SER LYS HIS ARG          
SEQRES   9 Z  125  ALA GLN VAL ILE TYR THR ARG ASN THR LYS GLY GLY ASP          
SEQRES  10 Z  125  ALA PRO ALA ALA GLY GLU ASP ALA                              
SEQRES   1 c   69  MET ASP THR SER ARG VAL GLN PRO ILE LYS LEU ALA ARG          
SEQRES   2 c   69  VAL THR LYS VAL LEU GLY ARG THR GLY SER GLN GLY GLN          
SEQRES   3 c   69  CYS THR GLN VAL ARG VAL GLU PHE MET ASP ASP THR SER          
SEQRES   4 c   69  ARG SER ILE ILE ARG ASN VAL LYS GLY PRO VAL ARG GLU          
SEQRES   5 c   69  GLY ASP VAL LEU THR LEU LEU GLU SER GLU ARG GLU ALA          
SEQRES   6 c   69  ARG ARG LEU ARG                                              
SEQRES   1 f  156  MET GLN ILE PHE VAL LYS THR LEU THR GLY LYS THR ILE          
SEQRES   2 f  156  THR LEU GLU VAL GLU PRO SER ASP THR ILE GLU ASN VAL          
SEQRES   3 f  156  LYS ALA LYS ILE GLN ASP LYS GLU GLY ILE PRO PRO ASP          
SEQRES   4 f  156  GLN GLN ARG LEU ILE PHE ALA GLY LYS GLN LEU GLU ASP          
SEQRES   5 f  156  GLY ARG THR LEU SER ASP TYR ASN ILE GLN LYS GLU SER          
SEQRES   6 f  156  THR LEU HIS LEU VAL LEU ARG LEU ARG GLY GLY ALA LYS          
SEQRES   7 f  156  LYS ARG LYS LYS LYS SER CYS THR THR PRO LYS LYS ASN          
SEQRES   8 f  156  LYS HIS LYS ARG LYS LYS VAL LYS LEU ALA VAL LEU LYS          
SEQRES   9 f  156  TYR TYR LYS VAL ASP GLU ASN GLY LYS ILE SER ARG LEU          
SEQRES  10 f  156  ARG ARG GLU CYS PRO SER ASP GLU CYS GLY ALA GLY VAL          
SEQRES  11 f  156  PHE MET ALA SER HIS PHE ASP ARG HIS TYR CYS GLY LYS          
SEQRES  12 f  156  CYS CYS LEU THR TYR CYS PHE ASN LYS PRO GLU ASP LYS          
SEQRES   1 g  317  MET THR GLU GLN MET THR LEU ARG GLY THR LEU LYS GLY          
SEQRES   2 g  317  HIS ASN GLY TRP VAL THR GLN ILE ALA THR THR PRO GLN          
SEQRES   3 g  317  PHE PRO ASP MET ILE LEU SER ALA SER ARG ASP LYS THR          
SEQRES   4 g  317  ILE ILE MET TRP LYS LEU THR ARG ASP GLU THR ASN TYR          
SEQRES   5 g  317  GLY ILE PRO GLN ARG ALA LEU ARG GLY HIS SER HIS PHE          
SEQRES   6 g  317  VAL SER ASP VAL VAL ILE SER SER ASP GLY GLN PHE ALA          
SEQRES   7 g  317  LEU SER GLY SER TRP ASP GLY THR LEU ARG LEU TRP ASP          
SEQRES   8 g  317  LEU THR THR GLY THR THR THR ARG ARG PHE VAL GLY HIS          
SEQRES   9 g  317  THR LYS ASP VAL LEU SER VAL ALA PHE SER SER ASP ASN          
SEQRES  10 g  317  ARG GLN ILE VAL SER GLY SER ARG ASP LYS THR ILE LYS          
SEQRES  11 g  317  LEU TRP ASN THR LEU GLY VAL CYS LYS TYR THR VAL GLN          
SEQRES  12 g  317  ASP GLU SER HIS SER GLU TRP VAL SER CYS VAL ARG PHE          
SEQRES  13 g  317  SER PRO ASN SER SER ASN PRO ILE ILE VAL SER CYS GLY          
SEQRES  14 g  317  TRP ASP LYS LEU VAL LYS VAL TRP ASN LEU ALA ASN CYS          
SEQRES  15 g  317  LYS LEU LYS THR ASN HIS ILE GLY HIS THR GLY TYR LEU          
SEQRES  16 g  317  ASN THR VAL THR VAL SER PRO ASP GLY SER LEU CYS ALA          
SEQRES  17 g  317  SER GLY GLY LYS ASP GLY GLN ALA MET LEU TRP ASP LEU          
SEQRES  18 g  317  ASN GLU GLY LYS HIS LEU TYR THR LEU ASP GLY GLY ASP          
SEQRES  19 g  317  ILE ILE ASN ALA LEU CYS PHE SER PRO ASN ARG TYR TRP          
SEQRES  20 g  317  LEU CYS ALA ALA THR GLY PRO SER ILE LYS ILE TRP ASP          
SEQRES  21 g  317  LEU GLU GLY LYS ILE ILE VAL ASP GLU LEU LYS GLN GLU          
SEQRES  22 g  317  VAL ILE SER THR SER SER LYS ALA GLU PRO PRO GLN CYS          
SEQRES  23 g  317  THR SER LEU ALA TRP SER ALA ASP GLY GLN THR LEU PHE          
SEQRES  24 g  317  ALA GLY TYR THR ASP ASN LEU VAL ARG VAL TRP GLN VAL          
SEQRES  25 g  317  THR ILE GLY THR ARG                                          
HET     ZN  a 201       1                                                       
HET     ZN  d 201       1                                                       
HET     ZN  f 500       1                                                       
HETNAM      ZN ZINC ION                                                         
FORMUL  36   ZN    3(ZN 2+)                                                     
HELIX    1 AA1 LYS A   11  GLY A   22  1                                  12    
HELIX    2 AA2 ASN A   50  GLU A   56  1                                   7    
HELIX    3 AA3 LEU A   60  ILE A   68  1                                   9    
HELIX    4 AA4 ASN A   70  ASP A   73  5                                   4    
HELIX    5 AA5 GLY A   83  LYS A   89  1                                   7    
HELIX    6 AA6 LYS A   89  GLY A   95  1                                   7    
HELIX    7 AA7 GLY A  167  ARG A  186  1                                  20    
HELIX    8 AA8 ASP B   23  SER B   26  5                                   4    
HELIX    9 AA9 ILE B   57  GLY B   64  1                                   8    
HELIX   10 AB1 THR B  106  VAL B  114  1                                   9    
HELIX   11 AB2 LYS B  167  VAL B  176  1                                  10    
HELIX   12 AB3 ASP B  180  ILE B  189  1                                  10    
HELIX   13 AB4 ASP B  191  CYS B  201  1                                  11    
HELIX   14 AB5 GLY B  226  LEU B  231  1                                   6    
HELIX   15 AB6 LEU C   66  ASP C   72  1                                   7    
HELIX   16 AB7 LEU C   78  SER C   85  1                                   8    
HELIX   17 AB8 GLU C   90  GLY C   99  1                                  10    
HELIX   18 AB9 ALA C  154  LYS C  159  1                                   6    
HELIX   19 AC1 LEU C  160  ILE C  162  5                                   3    
HELIX   20 AC2 VAL C  209  GLY C  218  1                                  10    
HELIX   21 AC3 THR C  232  ALA C  237  1                                   6    
HELIX   22 AC4 THR C  252  TRP C  256  5                                   5    
HELIX   23 AC5 SER C  264  PHE C  269  1                                   6    
HELIX   24 AC6 ASP C  271  THR C  276  1                                   6    
HELIX   25 AC7 VAL E   12  ALA E   14  5                                   3    
HELIX   26 AC8 PRO E   15  MET E   19  5                                   5    
HELIX   27 AC9 ILE E   45  ASN E   50  1                                   6    
HELIX   28 AD1 THR E   57  GLN E   67  1                                  11    
HELIX   29 AD2 GLU E  117  TYR E  121  5                                   5    
HELIX   30 AD3 ARG E  221  ILE E  225  5                                   5    
HELIX   31 AD4 THR E  247  LYS E  259  1                                  13    
HELIX   32 AD5 GLU G   43  GLY G   47  5                                   5    
HELIX   33 AD6 ARG G  140  PHE G  145  1                                   6    
HELIX   34 AD7 ASP G  152  VAL G  157  5                                   6    
HELIX   35 AD8 LEU G  212  LYS G  230  1                                  19    
HELIX   36 AD9 ASP H   17  SER H   34  1                                  18    
HELIX   37 AE1 LEU H   36  LEU H   43  1                                   8    
HELIX   38 AE2 LYS H   70  ILE H   75  1                                   6    
HELIX   39 AE3 ILE H   75  LYS H   86  1                                  12    
HELIX   40 AE4 THR H  121  ASP H  127  1                                   7    
HELIX   41 AE5 VAL H  166  VAL H  170  5                                   5    
HELIX   42 AE6 GLU H  171  THR H  181  1                                  11    
HELIX   43 AE7 ARG I   25  TYR I   27  5                                   3    
HELIX   44 AE8 ARG I   49  GLY I   51  5                                   3    
HELIX   45 AE9 SER I  106  GLN I  111  1                                   6    
HELIX   46 AF1 GLN I  111  HIS I  116  1                                   6    
HELIX   47 AF2 PRO I  131  ASN I  138  1                                   8    
HELIX   48 AF3 SER I  142  LYS I  154  1                                  13    
HELIX   49 AF4 LEU I  161  GLY I  169  1                                   9    
HELIX   50 AF5 ARG I  178  GLY I  183  1                                   6    
HELIX   51 AF6 GLU I  191  LYS I  206  1                                  16    
HELIX   52 AF7 GLU J   21  LEU J   29  1                                   9    
HELIX   53 AF8 LEU J   29  GLU J   34  1                                   6    
HELIX   54 AF9 ASP J   67  ASN J   75  1                                   9    
HELIX   55 AG1 LEU J   77  VAL J   82  1                                   6    
HELIX   56 AG2 LYS J   93  LEU J  100  5                                   8    
HELIX   57 AG3 LYS J  101  LEU J  106  1                                   6    
HELIX   58 AG4 ARG J  109  GLY J  118  1                                  10    
HELIX   59 AG5 HIS J  125  GLN J  132  1                                   8    
HELIX   60 AG6 ARG J  150  GLN J  154  5                                   5    
HELIX   61 AG7 VAL J  173  GLY J  181  1                                   9    
HELIX   62 AG8 VAL L   23  THR L   28  1                                   6    
HELIX   63 AG9 THR N   29  ALA N   41  1                                  13    
HELIX   64 AH1 LYS N   42  GLY N   44  5                                   3    
HELIX   65 AH2 THR N   46  SER N   57  1                                  12    
HELIX   66 AH3 GLN N   62  GLY N   68  1                                   7    
HELIX   67 AH4 ILE N   71  GLY N   79  1                                   9    
HELIX   68 AH5 PRO N   85  HIS N   90  1                                   6    
HELIX   69 AH6 LYS N   94  GLU N  103  1                                  10    
HELIX   70 AH7 LYS N  112  ILE N  116  5                                   5    
HELIX   71 AH8 LEU N  125  LYS N  130  1                                   6    
HELIX   72 AH9 SER N  143  SER N  147  5                                   5    
HELIX   73 AI1 VAL O   81  LYS O   86  1                                   6    
HELIX   74 AI2 GLY O  111  ARG O  121  1                                  11    
HELIX   75 AI3 CYS V   56  ARG V   61  1                                   6    
HELIX   76 AI4 ASP V   66  ALA V   75  1                                  10    
HELIX   77 AI5 ASN W    5  ALA W   10  1                                   6    
HELIX   78 AI6 ASN W   15  GLY W   21  1                                   7    
HELIX   79 AI7 PHE W   37  HIS W   44  1                                   8    
HELIX   80 AI8 ASP W   85  LEU W   94  1                                  10    
HELIX   81 AI9 GLN X   26  HIS X   31  1                                   6    
HELIX   82 AJ1 GLY X   33  ALA X   38  1                                   6    
HELIX   83 AJ2 GLU Y   39  LYS Y   49  1                                  11    
HELIX   84 AJ3 SER Y   78  GLU Y   86  1                                   9    
HELIX   85 AJ4 PRO Y   87  LEU Y   91  5                                   5    
HELIX   86 AJ5 LYS Y  105  MET Y  114  1                                  10    
HELIX   87 AJ6 VAL a   50  SER a   57  1                                   8    
HELIX   88 AJ7 VAL a   75  HIS a   80  1                                   6    
HELIX   89 AJ8 ARG d   32  LEU d   36  5                                   5    
HELIX   90 AJ9 GLN d   41  TYR d   46  1                                   6    
HELIX   91 AK1 TYR d   46  GLY d   51  1                                   6    
HELIX   92 AK2 LYS e   33  VAL e   43  1                                  11    
HELIX   93 AK3 LYS h   14  ARG h   21  1                                   8    
HELIX   94 AK4 SER D    6  VAL D   12  1                                   7    
HELIX   95 AK5 LYS D   18  LEU D   29  1                                  12    
HELIX   96 AK6 ALA D   30  ASP D   32  5                                   3    
HELIX   97 AK7 THR D   55  GLY D   60  1                                   6    
HELIX   98 AK8 ARG D   65  PHE D   77  1                                  13    
HELIX   99 AK9 SER D  104  GLY D  111  1                                   8    
HELIX  100 AL1 ALA D  114  GLU D  128  1                                  15    
HELIX  101 AL2 GLY D  161  ASN D  165  5                                   5    
HELIX  102 AL3 PRO F   67  MET F   77  1                                  11    
HELIX  103 AL4 THR F   89  GLY F  105  1                                  17    
HELIX  104 AL5 LEU F  109  ASN F  118  1                                  10    
HELIX  105 AL6 SER F  142  ALA F  161  1                                  20    
HELIX  106 AL7 ALA F  170  GLY F  183  1                                  14    
HELIX  107 AL8 SER F  187  LYS F  192  1                                   6    
HELIX  108 AL9 LYS F  192  SER F  202  1                                  11    
HELIX  109 AM1 PRO K    4  TYR K   12  1                                   9    
HELIX  110 AM2 TYR K   12  GLY K   19  1                                   8    
HELIX  111 AM3 PRO K   41  LEU K   52  1                                  12    
HELIX  112 AM4 THR K   72  LEU K   83  1                                  12    
HELIX  113 AM5 ALA M   17  LEU M   26  1                                  10    
HELIX  114 AM6 ILE M   35  ALA M   41  1                                   7    
HELIX  115 AM7 GLU M   58  HIS M   72  1                                  15    
HELIX  116 AM8 LYS M   83  TRP M   88  1                                   6    
HELIX  117 AM9 GLN M  119  CYS M  130  1                                  12    
HELIX  118 AN1 LEU P   22  MET P   28  1                                   7    
HELIX  119 AN2 SER P   29  GLN P   35  1                                   7    
HELIX  120 AN3 SER P   38  GLY P   48  1                                  11    
HELIX  121 AN4 SER P   55  LYS P   64  1                                  10    
HELIX  122 AN5 LEU P   86  VAL P   90  5                                   5    
HELIX  123 AN6 LYS P  108  ILE P  112  5                                   5    
HELIX  124 AN7 TYR P  115  SER P  120  5                                   6    
HELIX  125 AN8 GLU Q   40  ILE Q   42  5                                   3    
HELIX  126 AN9 PRO Q   44  THR Q   46  5                                   3    
HELIX  127 AO1 LEU Q   47  LEU Q   52  1                                   6    
HELIX  128 AO2 LEU Q   52  GLY Q   59  1                                   8    
HELIX  129 AO3 LYS Q   60  ALA Q   64  5                                   5    
HELIX  130 AO4 GLY Q   76  TYR Q   82  1                                   7    
HELIX  131 AO5 ARG Q   85  TYR Q   99  1                                  15    
HELIX  132 AO6 ASP Q  101  GLN Q  114  1                                  14    
HELIX  133 AO7 ASP Q  116  LEU Q  120  5                                   5    
HELIX  134 AO8 THR R    6  TYR R   20  1                                  15    
HELIX  135 AO9 HIS R   29  VAL R   34  1                                   6    
HELIX  136 AP1 VAL R   34  ILE R   38  1                                   5    
HELIX  137 AP2 SER R   43  ALA R   51  1                                   9    
HELIX  138 AP3 ALA R   51  ARG R   60  1                                  10    
HELIX  139 AP4 ILE R   61  GLY R   64  5                                   4    
HELIX  140 AP5 GLU R   76  ARG R   81  1                                   6    
HELIX  141 AP6 THR R  102  LEU R  108  1                                   7    
HELIX  142 AP7 LYS S   25  THR S   31  1                                   7    
HELIX  143 AP8 GLY S   37  ASP S   49  1                                  13    
HELIX  144 AP9 THR S   60  MET S   71  1                                  12    
HELIX  145 AQ1 PRO S   74  LYS S   78  5                                   5    
HELIX  146 AQ2 LEU S   99  GLU S  112  1                                  14    
HELIX  147 AQ3 ARG S  121  GLY S  128  1                                   8    
HELIX  148 AQ4 THR T    5  VAL T    9  5                                   5    
HELIX  149 AQ5 ASN T   10  ALA T   17  1                                   8    
HELIX  150 AQ6 ALA T   19  LYS T   24  1                                   6    
HELIX  151 AQ7 SER T   59  LEU T   64  1                                   6    
HELIX  152 AQ8 VAL T   72  THR T   76  5                                   5    
HELIX  153 AQ9 ALA T  100  ALA T  106  1                                   7    
HELIX  154 AR1 LEU T  107  LYS T  111  5                                   5    
HELIX  155 AR2 GLN T  126  LYS T  144  1                                  19    
HELIX  156 AR3 ASN U   28  LYS U   46  1                                  19    
HELIX  157 AR4 PRO U   94  ILE U  104  1                                  11    
HELIX  158 AR5 ASP Z   51  CYS Z   59  1                                   9    
HELIX  159 AR6 GLU Z   61  TYR Z   65  5                                   5    
HELIX  160 AR7 THR Z   69  LEU Z   77  1                                   9    
HELIX  161 AR8 SER Z   82  GLN Z   89  1                                   8    
HELIX  162 AR9 GLN Z   89  GLY Z   95  1                                   7    
HELIX  163 AS1 ALA f  101  TYR f  106  1                                   6    
SHEET    1 AA1 2 ILE A  38  ARG A  41  0                                        
SHEET    2 AA1 2 TYR A  47  ILE A  49 -1  O  ILE A  48   N  TYR A  39           
SHEET    1 AA2 5 THR A  97  ILE A  99  0                                        
SHEET    2 AA2 5 SER A  75  ILE A  77  1  N  VAL A  76   O  ILE A  99           
SHEET    3 AA2 5 LEU A 122  VAL A 124  1  O  VAL A 123   N  SER A  75           
SHEET    4 AA2 5 THR A 144  ALA A 146  1  O  ILE A 145   N  LEU A 122           
SHEET    5 AA2 5 ILE A 159  ALA A 160  1  O  ILE A 159   N  ALA A 146           
SHEET    1 AA3 4 ASN B  43  THR B  50  0                                        
SHEET    2 AA3 4 LYS B  28  LYS B  34 -1  N  VAL B  33   O  ILE B  44           
SHEET    3 AA3 4 CYS B  96  THR B  98  1  O  CYS B  96   N  LYS B  34           
SHEET    4 AA3 4 THR B  88  VAL B  91 -1  N  GLU B  89   O  LEU B  97           
SHEET    1 AA4 2 ARG B  82  LYS B  85  0                                        
SHEET    2 AA4 2 GLY B 102  LEU B 105 -1  O  ASP B 104   N  LYS B  83           
SHEET    1 AA5 2 MET B 120  ALA B 123  0                                        
SHEET    2 AA5 2 CYS B 139  PHE B 142 -1  O  GLY B 141   N  ILE B 121           
SHEET    1 AA6 3 LYS C 103  VAL C 106  0                                        
SHEET    2 AA6 3 ALA C 126  GLY C 131 -1  O  GLY C 131   N  LYS C 103           
SHEET    3 AA6 3 VAL C 141  LYS C 142 -1  O  LYS C 142   N  ALA C 126           
SHEET    1 AA7 2 HIS C 136  VAL C 137  0                                        
SHEET    2 AA7 2 VAL C 163  PRO C 164 -1  O  VAL C 163   N  VAL C 137           
SHEET    1 AA8 2 ILE C 204  VAL C 205  0                                        
SHEET    2 AA8 2 CYS C 222  TYR C 223  1  O  CYS C 222   N  VAL C 205           
SHEET    1 AA9 2 LEU E   9  LYS E  10  0                                        
SHEET    2 AA9 2 PHE E  27  ALA E  28 -1  O  ALA E  28   N  LEU E   9           
SHEET    1 AB1 2 LEU E  42  PRO E  43  0                                        
SHEET    2 AB1 2 PRO E  83  ALA E  84 -1  O  ALA E  84   N  LEU E  42           
SHEET    1 AB2 2 VAL E 131  GLY E 132  0                                        
SHEET    2 AB2 2 ILE E 136  PRO E 137 -1  N  ILE E 136   O  GLY E 132           
SHEET    1 AB3 2 ILE E 162  ASP E 163  0                                        
SHEET    2 AB3 2 LYS E 168  ILE E 169 -1  O  LYS E 168   N  ASP E 163           
SHEET    1 AB4 2 LEU E 180  MET E 182  0                                        
SHEET    2 AB4 2 ILE E 192  VAL E 194 -1  O  GLY E 193   N  CYS E 181           
SHEET    1 AB5 2 VAL E 210  LYS E 211  0                                        
SHEET    2 AB5 2 SER E 217  PHE E 218 -1  O  PHE E 218   N  VAL E 210           
SHEET    1 AB6 2 ASN G  56  ASP G  57  0                                        
SHEET    2 AB6 2 LEU G 106  VAL G 108 -1  O  SER G 107   N  ASN G  56           
SHEET    1 AB7 2 ARG G  72  VAL G  73  0                                        
SHEET    2 AB7 2 VAL G  97  ARG G  98 -1  O  VAL G  97   N  VAL G  73           
SHEET    1 AB8 3 LYS H  49  GLU H  52  0                                        
SHEET    2 AB8 3 LYS H  58  VAL H  64 -1  O  ALA H  59   N  ILE H  51           
SHEET    3 AB8 3 HIS H  91  ALA H  96  1  O  ILE H  95   N  VAL H  64           
SHEET    1 AB9 3 LYS H 155  LEU H 158  0                                        
SHEET    2 AB9 3 ILE H 139  ILE H 144 -1  N  VAL H 140   O  HIS H 157           
SHEET    3 AB9 3 ILE W  52  ILE W  53 -1  O  ILE W  52   N  ILE H 144           
SHEET    1 AC1 2 ILE I   3  SER I   4  0                                        
SHEET    2 AC1 2 LEU I  29  GLY I  30 -1  O  GLY I  30   N  ILE I   3           
SHEET    1 AC2 3 LYS I  37  ILE I  38  0                                        
SHEET    2 AC2 3 LYS I  53  LEU I  60  1  O  LEU I  58   N  LYS I  37           
SHEET    3 AC2 3 ARG I  42  ARG I  47 -1  N  VAL I  46   O  LYS I  54           
SHEET    1 AC3 3 ARG I  74  ARG I  77  0                                        
SHEET    2 AC3 3 VAL I  62  SER I  66 -1  N  PHE I  65   O  ARG I  74           
SHEET    3 AC3 3 GLY I 187  TYR I 188  1  O  GLY I 187   N  SER I  66           
SHEET    1 AC4 2 ARG J 136  VAL J 137  0                                        
SHEET    2 AC4 2 GLN J 140  VAL J 141 -1  N  GLN J 140   O  VAL J 137           
SHEET    1 AC5 2 VAL L  76  VAL L  77  0                                        
SHEET    2 AC5 2 ILE L  88  ARG L  89 -1  O  ARG L  89   N  VAL L  76           
SHEET    1 AC6 2 THR L  85  ILE L  86  0                                        
SHEET    2 AC6 2 VAL L 111  HIS L 112 -1  O  VAL L 111   N  ILE L  86           
SHEET    1 AC7 2 ASP L  91  LEU L  93  0                                        
SHEET    2 AC7 2 LYS L 104  HIS L 106 -1  O  ARG L 105   N  TYR L  92           
SHEET    1 AC8 2 VAL L 128  GLU L 130  0                                        
SHEET    2 AC8 2 PHE L 140  VAL L 142 -1  O  ASN L 141   N  GLY L 129           
SHEET    1 AC9 3 PHE O  28  CYS O  31  0                                        
SHEET    2 AC9 3 ALA O  92  ILE O  95  1  O  HIS O  94   N  GLY O  29           
SHEET    3 AC9 3 LYS O 125  ILE O 126  1  O  LYS O 125   N  LEU O  93           
SHEET    1 AD1 2 VAL O  42  THR O  45  0                                        
SHEET    2 AD1 2 THR O  52  VAL O  56 -1  O  VAL O  56   N  VAL O  42           
SHEET    1 AD2 2 VAL V  36  VAL V  39  0                                        
SHEET    2 AD2 2 PHE V  46  LYS V  51 -1  O  GLN V  49   N  GLU V  38           
SHEET    1 AD3 2 GLN W  24  VAL W  25  0                                        
SHEET    2 AD3 2 VAL W  63  ASN W  64 -1  N  VAL W  63   O  VAL W  25           
SHEET    1 AD4 2 ASP W  80  VAL W  81  0                                        
SHEET    2 AD4 2 GLY W 123  LYS W 124 -1  O  GLY W 123   N  VAL W  81           
SHEET    1 AD5 2 LEU W 104  THR W 105  0                                        
SHEET    2 AD5 2 ILE W 110  MET W 111 -1  O  MET W 111   N  LEU W 104           
SHEET    1 AD6 6 ALA X  47  ILE X  50  0                                        
SHEET    2 AD6 6 GLU X  99  GLY X 104 -1  O  VAL X 100   N  GLY X  49           
SHEET    3 AD6 6 PHE X 120  VAL X 122 -1  O  LYS X 121   N  ALA X 103           
SHEET    4 AD6 6 LYS X  80  PHE X  84  1  N  PHE X  84   O  VAL X 122           
SHEET    5 AD6 6 ILE X  66  GLN X  73 -1  N  VAL X  70   O  ALA X  83           
SHEET    6 AD6 6 GLY X  56  GLU X  58 -1  N  VAL X  57   O  ARG X  67           
SHEET    1 AD7 2 LYS X 124  VAL X 125  0                                        
SHEET    2 AD7 2 VAL X 128  SER X 129 -1  O  VAL X 128   N  VAL X 125           
SHEET    1 AD8 2 ILE Y   7  THR Y   9  0                                        
SHEET    2 AD8 2 ILE Y  25  VAL Y  27 -1  O  ASP Y  26   N  ARG Y   8           
SHEET    1 AD9 2 PRO a  20  ARG a  22  0                                        
SHEET    2 AD9 2 CYS a  29  PRO a  31 -1  O  VAL a  30   N  ILE a  21           
SHEET    1 AE1 2 ILE a  36  ASN a  43  0                                        
SHEET    2 AE1 2 LYS a  66  TYR a  73 -1  O  VAL a  69   N  VAL a  40           
SHEET    1 AE2 2 CYS b  64  GLN b  65  0                                        
SHEET    2 AE2 2 ARG b  72  LEU b  73 -1  O  ARG b  72   N  GLN b  65           
SHEET    1 AE3 2 LEU d  30  ILE d  31  0                                        
SHEET    2 AE3 2 MET d  38  CYS d  39 -1  O  MET d  38   N  ILE d  31           
SHEET    1 AE4 3 VAL D  37  ARG D  40  0                                        
SHEET    2 AE4 3 THR D  46  ALA D  52 -1  O  GLU D  47   N  ARG D  40           
SHEET    3 AE4 3 VAL D  84  LYS D  90  1  O  TYR D  87   N  ILE D  50           
SHEET    1 AE5 2 GLY D 133  CYS D 134  0                                        
SHEET    2 AE5 2 ASP D 154  GLY D 155 -1  O  ASP D 154   N  CYS D 134           
SHEET    1 AE6 3 VAL D 136  GLY D 140  0                                        
SHEET    2 AE6 3 LEU D 182  MET D 189 -1  O  LYS D 185   N  VAL D 137           
SHEET    3 AE6 3 VAL D 168  VAL D 175 -1  N  ASP D 169   O  ILE D 188           
SHEET    1 AE7 2 SER D 209  ILE D 210  0                                        
SHEET    2 AE7 2 ALA R  39  ILE R  40 -1  O  ILE R  40   N  SER D 209           
SHEET    1 AE8 2 ILE D 223  SER D 224  0                                        
SHEET    2 AE8 2 HIS g 188  ILE g 189 -1  O  ILE g 189   N  ILE D 223           
SHEET    1 AE9 2 GLU F 123  ASP F 124  0                                        
SHEET    2 AE9 2 VAL F 139  ASP F 140 -1  O  VAL F 139   N  ASP F 124           
SHEET    1 AF1 3 LEU M  76  VAL M  79  0                                        
SHEET    2 AF1 3 LEU M  49  ALA M  53  1  N  LEU M  52   O  ILE M  77           
SHEET    3 AF1 3 CYS M 108  VAL M 111 -1  O  VAL M 109   N  VAL M  51           
SHEET    1 AF2 2 THR P  16  TYR P  17  0                                        
SHEET    2 AF2 2 VAL P  20  ASP P  21 -1  O  VAL P  20   N  TYR P  17           
SHEET    1 AF3 2 LYS Q  26  ARG Q  27  0                                        
SHEET    2 AF3 2 VAL Q  66  ASP Q  67 -1  N  ASP Q  67   O  LYS Q  26           
SHEET    1 AF4 2 LYS Q  33  VAL Q  34  0                                        
SHEET    2 AF4 2 ARG Q  37  PRO Q  38 -1  O  ARG Q  37   N  VAL Q  34           
SHEET    1 AF5 2 ILE R  96  VAL R  98  0                                        
SHEET    2 AF5 2 LEU R 117  VAL R 119  1  O  GLN R 118   N  VAL R  98           
SHEET    1 AF6 2 ILE S  12  ARG S  14  0                                        
SHEET    2 AF6 2 ASN S  19  ASP S  21 -1  O  ILE S  20   N  LEU S  13           
SHEET    1 AF7 2 GLY T  81  GLN T  83  0                                        
SHEET    2 AF7 2 HIS T  91  SER T  93 -1  O  SER T  93   N  GLY T  81           
SHEET    1 AF8 2 VAL T 113  LYS T 115  0                                        
SHEET    2 AF8 2 ARG T 121  LEU T 123 -1  O  LYS T 122   N  GLU T 114           
SHEET    1 AF9 3 VAL U  54  ARG U  55  0                                        
SHEET    2 AF9 3 PHE U  80  ASP U  90 -1  O  LEU U  88   N  VAL U  54           
SHEET    3 AF9 3 LYS U  59  ILE U  63 -1  N  LEU U  61   O  MET U  82           
SHEET    1 AG1 4 VAL U  54  ARG U  55  0                                        
SHEET    2 AG1 4 PHE U  80  ASP U  90 -1  O  LEU U  88   N  VAL U  54           
SHEET    3 AG1 4 ARG U  21  SER U  26 -1  N  SER U  26   O  HIS U  85           
SHEET    4 AG1 4 VAL U 110  THR U 115 -1  O  GLU U 113   N  THR U  23           
SHEET    1 AG2 2 ILE Z  97  LYS Z 102  0                                        
SHEET    2 AG2 2 VAL Z 107  ARG Z 111 -1  O  ILE Z 108   N  SER Z 101           
SHEET    1 AG3 2 LYS c  10  LEU c  11  0                                        
SHEET    2 AG3 2 THR c  57  LEU c  58 -1  O  LEU c  58   N  LYS c  10           
SHEET    1 AG4 3 VAL c  17  GLY c  19  0                                        
SHEET    2 AG4 3 GLN c  29  VAL c  30 -1  O  GLN c  29   N  LEU c  18           
SHEET    3 AG4 3 ARG c  44  ASN c  45 -1  O  ARG c  44   N  VAL c  30           
SHEET    1 AG5 2 HIS f 139  TYR f 140  0                                        
SHEET    2 AG5 2 THR f 147  TYR f 148 -1  O  TYR f 148   N  HIS f 139           
SHEET    1 AG6 3 GLN g   4  LEU g  11  0                                        
SHEET    2 AG6 3 VAL g 307  THR g 313 -1  O  VAL g 307   N  LEU g  11           
SHEET    3 AG6 3 PHE g 299  ALA g 300 -1  N  ALA g 300   O  ARG g 308           
SHEET    1 AG7 3 LEU g  32  SER g  33  0                                        
SHEET    2 AG7 3 THR g  39  LYS g  44 -1  O  ILE g  41   N  SER g  33           
SHEET    3 AG7 3 ILE g  54  ARG g  60 -1  O  GLN g  56   N  MET g  42           
SHEET    1 AG8 2 VAL g  70  ILE g  71  0                                        
SHEET    2 AG8 2 ALA g  78  LEU g  79 -1  O  LEU g  79   N  VAL g  70           
SHEET    1 AG9 2 ALA g 112  PHE g 113  0                                        
SHEET    2 AG9 2 ILE g 120  VAL g 121 -1  O  VAL g 121   N  ALA g 112           
SHEET    1 AH1 3 CYS g 153  SER g 157  0                                        
SHEET    2 AH1 3 ILE g 164  CYS g 168 -1  O  VAL g 166   N  ARG g 155           
SHEET    3 AH1 3 LYS g 175  ASN g 178 -1  O  TRP g 177   N  ILE g 165           
SHEET    1 AH2 4 THR g 199  VAL g 200  0                                        
SHEET    2 AH2 4 LEU g 206  ALA g 208 -1  O  ALA g 208   N  THR g 199           
SHEET    3 AH2 4 MET g 217  ASP g 220 -1  O  TRP g 219   N  CYS g 207           
SHEET    4 AH2 4 LYS g 225  THR g 229 -1  O  LEU g 227   N  LEU g 218           
SHEET    1 AH3 3 TRP g 247  CYS g 249  0                                        
SHEET    2 AH3 3 ILE g 256  ASP g 260 -1  O  TRP g 259   N  LEU g 248           
SHEET    3 AH3 3 ILE g 266  LEU g 270 -1  O  VAL g 267   N  ILE g 258           
LINK         N   CYS a  26                ZN    ZN a 201     1555   1555  2.63  
LINK         SG  CYS a  26                ZN    ZN a 201     1555   1555  2.46  
LINK         SG  CYS a  74                ZN    ZN a 201     1555   1555  2.42  
LINK         SG  CYS a  77                ZN    ZN a 201     1555   1555  2.50  
LINK         SG  CYS d  21                ZN    ZN d 201     1555   1555  2.19  
LINK         SG  CYS d  24                ZN    ZN d 201     1555   1555  2.39  
LINK         SG  CYS d  42                ZN    ZN d 201     1555   1555  2.67  
LINK         SG  CYS f 126                ZN    ZN f 500     1555   1555  2.66  
LINK         SG  CYS f 141                ZN    ZN f 500     1555   1555  2.49  
LINK         N   CYS f 144                ZN    ZN f 500     1555   1555  2.25  
CISPEP   1 ARG W   28    PRO W   29          0       -14.01                     
CISPEP   2 SER W   76    PRO W   77          0        -4.43                     
SITE     1 AC1  4 CYS a  23  CYS a  26  CYS a  74  CYS a  77                    
SITE     1 AC2  5 CYS d  21  VAL d  23  CYS d  24  CYS d  39                    
SITE     2 AC2  5 CYS d  42                                                     
SITE     1 AC3  4 CYS f 126  CYS f 141  LYS f 143  CYS f 144                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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