HEADER RIBOSOME 29-MAR-18 6G5I
TITLE CRYO-EM STRUCTURE OF A LATE HUMAN PRE-40S RIBOSOMAL SUBUNIT - STATE R
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: 18S RIBOSOMAL RNA;
COMPND 3 CHAIN: 2;
COMPND 4 MOL_ID: 2;
COMPND 5 MOLECULE: 40S RIBOSOMAL PROTEIN SA;
COMPND 6 CHAIN: A;
COMPND 7 SYNONYM: 37 KDA LAMININ RECEPTOR PRECURSOR,37LRP,37/67 KDA LAMININ
COMPND 8 RECEPTOR,LRP/LR,67 KDA LAMININ RECEPTOR,67LR,COLON CARCINOMA LAMININ-
COMPND 9 BINDING PROTEIN,LAMININ RECEPTOR 1,LAMR,LAMININ-BINDING PROTEIN
COMPND 10 PRECURSOR P40,LBP/P40,MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN MGR1-
COMPND 11 AG,NEM/1CHD4,SMALL RIBOSOMAL SUBUNIT PROTEIN US2;
COMPND 12 MOL_ID: 3;
COMPND 13 MOLECULE: 40S RIBOSOMAL PROTEIN S3A;
COMPND 14 CHAIN: B;
COMPND 15 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES1,V-FOS TRANSFORMATION
COMPND 16 EFFECTOR PROTEIN,FTE-1;
COMPND 17 MOL_ID: 4;
COMPND 18 MOLECULE: 40S RIBOSOMAL PROTEIN S2;
COMPND 19 CHAIN: C;
COMPND 20 SYNONYM: 40S RIBOSOMAL PROTEIN S4,PROTEIN LLREP3,SMALL RIBOSOMAL
COMPND 21 SUBUNIT PROTEIN US5;
COMPND 22 MOL_ID: 5;
COMPND 23 MOLECULE: 40S RIBOSOMAL PROTEIN S3;
COMPND 24 CHAIN: D;
COMPND 25 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US3;
COMPND 26 EC: 4.2.99.18;
COMPND 27 MOL_ID: 6;
COMPND 28 MOLECULE: 40S RIBOSOMAL PROTEIN S4, X ISOFORM;
COMPND 29 CHAIN: E;
COMPND 30 SYNONYM: SCR10,SINGLE COPY ABUNDANT MRNA PROTEIN,SMALL RIBOSOMAL
COMPND 31 SUBUNIT PROTEIN ES4;
COMPND 32 MOL_ID: 7;
COMPND 33 MOLECULE: 40S RIBOSOMAL PROTEIN S5;
COMPND 34 CHAIN: F;
COMPND 35 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US7;
COMPND 36 MOL_ID: 8;
COMPND 37 MOLECULE: 40S RIBOSOMAL PROTEIN S6;
COMPND 38 CHAIN: G;
COMPND 39 SYNONYM: PHOSPHOPROTEIN NP33,SMALL RIBOSOMAL SUBUNIT PROTEIN ES6;
COMPND 40 MOL_ID: 9;
COMPND 41 MOLECULE: 40S RIBOSOMAL PROTEIN S7;
COMPND 42 CHAIN: H;
COMPND 43 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES7;
COMPND 44 MOL_ID: 10;
COMPND 45 MOLECULE: 40S RIBOSOMAL PROTEIN S8;
COMPND 46 CHAIN: I;
COMPND 47 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES8;
COMPND 48 MOL_ID: 11;
COMPND 49 MOLECULE: 40S RIBOSOMAL PROTEIN S9;
COMPND 50 CHAIN: J;
COMPND 51 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US4;
COMPND 52 MOL_ID: 12;
COMPND 53 MOLECULE: 40S RIBOSOMAL PROTEIN S10;
COMPND 54 CHAIN: K;
COMPND 55 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES10;
COMPND 56 MOL_ID: 13;
COMPND 57 MOLECULE: 40S RIBOSOMAL PROTEIN S11;
COMPND 58 CHAIN: L;
COMPND 59 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US17;
COMPND 60 MOL_ID: 14;
COMPND 61 MOLECULE: 40S RIBOSOMAL PROTEIN S12;
COMPND 62 CHAIN: M;
COMPND 63 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES12;
COMPND 64 MOL_ID: 15;
COMPND 65 MOLECULE: 40S RIBOSOMAL PROTEIN S13;
COMPND 66 CHAIN: N;
COMPND 67 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US15;
COMPND 68 MOL_ID: 16;
COMPND 69 MOLECULE: 40S RIBOSOMAL PROTEIN S14;
COMPND 70 CHAIN: O;
COMPND 71 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US11;
COMPND 72 MOL_ID: 17;
COMPND 73 MOLECULE: 40S RIBOSOMAL PROTEIN S15;
COMPND 74 CHAIN: P;
COMPND 75 SYNONYM: RIG PROTEIN,SMALL RIBOSOMAL SUBUNIT PROTEIN US19;
COMPND 76 MOL_ID: 18;
COMPND 77 MOLECULE: 40S RIBOSOMAL PROTEIN S16;
COMPND 78 CHAIN: Q;
COMPND 79 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US9;
COMPND 80 MOL_ID: 19;
COMPND 81 MOLECULE: 40S RIBOSOMAL PROTEIN S17;
COMPND 82 CHAIN: R;
COMPND 83 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES17;
COMPND 84 MOL_ID: 20;
COMPND 85 MOLECULE: 40S RIBOSOMAL PROTEIN S18;
COMPND 86 CHAIN: S;
COMPND 87 SYNONYM: KE-3,KE3,SMALL RIBOSOMAL SUBUNIT PROTEIN US13;
COMPND 88 MOL_ID: 21;
COMPND 89 MOLECULE: 40S RIBOSOMAL PROTEIN S19;
COMPND 90 CHAIN: T;
COMPND 91 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES19;
COMPND 92 MOL_ID: 22;
COMPND 93 MOLECULE: 40S RIBOSOMAL PROTEIN S20;
COMPND 94 CHAIN: U;
COMPND 95 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US10;
COMPND 96 MOL_ID: 23;
COMPND 97 MOLECULE: 40S RIBOSOMAL PROTEIN S21;
COMPND 98 CHAIN: V;
COMPND 99 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES21;
COMPND 100 MOL_ID: 24;
COMPND 101 MOLECULE: 40S RIBOSOMAL PROTEIN S15A;
COMPND 102 CHAIN: W;
COMPND 103 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US8;
COMPND 104 MOL_ID: 25;
COMPND 105 MOLECULE: 40S RIBOSOMAL PROTEIN S23;
COMPND 106 CHAIN: X;
COMPND 107 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US12;
COMPND 108 MOL_ID: 26;
COMPND 109 MOLECULE: 40S RIBOSOMAL PROTEIN S24;
COMPND 110 CHAIN: Y;
COMPND 111 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES24;
COMPND 112 MOL_ID: 27;
COMPND 113 MOLECULE: 40S RIBOSOMAL PROTEIN S25;
COMPND 114 CHAIN: Z;
COMPND 115 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES25;
COMPND 116 MOL_ID: 28;
COMPND 117 MOLECULE: 40S RIBOSOMAL PROTEIN S27;
COMPND 118 CHAIN: b;
COMPND 119 SYNONYM: METALLOPAN-STIMULIN 1,MPS-1,SMALL RIBOSOMAL SUBUNIT PROTEIN
COMPND 120 ES27;
COMPND 121 MOL_ID: 29;
COMPND 122 MOLECULE: 40S RIBOSOMAL PROTEIN S28;
COMPND 123 CHAIN: c;
COMPND 124 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES28;
COMPND 125 MOL_ID: 30;
COMPND 126 MOLECULE: 40S RIBOSOMAL PROTEIN S29;
COMPND 127 CHAIN: d;
COMPND 128 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN US14;
COMPND 129 MOL_ID: 31;
COMPND 130 MOLECULE: 40S RIBOSOMAL PROTEIN S30;
COMPND 131 CHAIN: e;
COMPND 132 SYNONYM: SMALL RIBOSOMAL SUBUNIT PROTEIN ES30;
COMPND 133 MOL_ID: 32;
COMPND 134 MOLECULE: RIBOSOMAL PROTEIN S27A;
COMPND 135 CHAIN: f;
COMPND 136 MOL_ID: 33;
COMPND 137 MOLECULE: RECEPTOR OF ACTIVATED PROTEIN C KINASE 1;
COMPND 138 CHAIN: g;
COMPND 139 SYNONYM: CELL PROLIFERATION-INDUCING GENE 21 PROTEIN,GUANINE
COMPND 140 NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-2-LIKE 1,GUANINE NUCLEOTIDE-
COMPND 141 BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 12.3,HUMAN LUNG CANCER
COMPND 142 ONCOGENE 7 PROTEIN,HLC-7,RECEPTOR FOR ACTIVATED C KINASE,SMALL
COMPND 143 RIBOSOMAL SUBUNIT PROTEIN RACK1;
COMPND 144 MOL_ID: 34;
COMPND 145 MOLECULE: RNA-BINDING PROTEIN PNO1;
COMPND 146 CHAIN: x;
COMPND 147 ENGINEERED: YES;
COMPND 148 MOL_ID: 35;
COMPND 149 MOLECULE: RNA-BINDING PROTEIN NOB1;
COMPND 150 CHAIN: y;
COMPND 151 SYNONYM: PHOSPHORYLATION REGULATORY PROTEIN HP-10,PROTEIN ART-4;
COMPND 152 ENGINEERED: YES;
COMPND 153 MOL_ID: 36;
COMPND 154 MOLECULE: SERINE/THREONINE-PROTEIN KINASE RIO1;
COMPND 155 CHAIN: z;
COMPND 156 SYNONYM: RIO KINASE 1;
COMPND 157 EC: 2.7.11.1,3.6.3.-;
COMPND 158 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_TAXID: 9606;
SOURCE 4 CELL_LINE: HEK293;
SOURCE 5 MOL_ID: 2;
SOURCE 6 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 7 ORGANISM_COMMON: HUMAN;
SOURCE 8 ORGANISM_TAXID: 9606;
SOURCE 9 CELL_LINE: HEK293;
SOURCE 10 MOL_ID: 3;
SOURCE 11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 12 ORGANISM_COMMON: HUMAN;
SOURCE 13 ORGANISM_TAXID: 9606;
SOURCE 14 CELL_LINE: HEK293;
SOURCE 15 MOL_ID: 4;
SOURCE 16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 17 ORGANISM_COMMON: HUMAN;
SOURCE 18 ORGANISM_TAXID: 9606;
SOURCE 19 CELL_LINE: HEK293;
SOURCE 20 MOL_ID: 5;
SOURCE 21 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 22 ORGANISM_COMMON: HUMAN;
SOURCE 23 ORGANISM_TAXID: 9606;
SOURCE 24 CELL_LINE: HEK293;
SOURCE 25 MOL_ID: 6;
SOURCE 26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 27 ORGANISM_COMMON: HUMAN;
SOURCE 28 ORGANISM_TAXID: 9606;
SOURCE 29 CELL_LINE: HEK293;
SOURCE 30 MOL_ID: 7;
SOURCE 31 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 32 ORGANISM_COMMON: HUMAN;
SOURCE 33 ORGANISM_TAXID: 9606;
SOURCE 34 CELL_LINE: HEK293;
SOURCE 35 MOL_ID: 8;
SOURCE 36 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 37 ORGANISM_COMMON: HUMAN;
SOURCE 38 ORGANISM_TAXID: 9606;
SOURCE 39 CELL_LINE: HEK293;
SOURCE 40 MOL_ID: 9;
SOURCE 41 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 42 ORGANISM_COMMON: HUMAN;
SOURCE 43 ORGANISM_TAXID: 9606;
SOURCE 44 CELL_LINE: HEK293;
SOURCE 45 MOL_ID: 10;
SOURCE 46 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 47 ORGANISM_COMMON: HUMAN;
SOURCE 48 ORGANISM_TAXID: 9606;
SOURCE 49 CELL_LINE: HEK293;
SOURCE 50 MOL_ID: 11;
SOURCE 51 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 52 ORGANISM_COMMON: HUMAN;
SOURCE 53 ORGANISM_TAXID: 9606;
SOURCE 54 CELL_LINE: HEK293;
SOURCE 55 MOL_ID: 12;
SOURCE 56 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 57 ORGANISM_COMMON: HUMAN;
SOURCE 58 ORGANISM_TAXID: 9606;
SOURCE 59 CELL_LINE: HEK293;
SOURCE 60 MOL_ID: 13;
SOURCE 61 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 62 ORGANISM_COMMON: HUMAN;
SOURCE 63 ORGANISM_TAXID: 9606;
SOURCE 64 CELL_LINE: HEK293;
SOURCE 65 MOL_ID: 14;
SOURCE 66 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 67 ORGANISM_COMMON: HUMAN;
SOURCE 68 ORGANISM_TAXID: 9606;
SOURCE 69 CELL_LINE: HEK293;
SOURCE 70 MOL_ID: 15;
SOURCE 71 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 72 ORGANISM_COMMON: HUMAN;
SOURCE 73 ORGANISM_TAXID: 9606;
SOURCE 74 CELL_LINE: HEK293;
SOURCE 75 MOL_ID: 16;
SOURCE 76 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 77 ORGANISM_COMMON: HUMAN;
SOURCE 78 ORGANISM_TAXID: 9606;
SOURCE 79 CELL_LINE: HEK293;
SOURCE 80 MOL_ID: 17;
SOURCE 81 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 82 ORGANISM_COMMON: HUMAN;
SOURCE 83 ORGANISM_TAXID: 9606;
SOURCE 84 CELL_LINE: HEK293;
SOURCE 85 MOL_ID: 18;
SOURCE 86 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 87 ORGANISM_COMMON: HUMAN;
SOURCE 88 ORGANISM_TAXID: 9606;
SOURCE 89 CELL_LINE: HEK293;
SOURCE 90 MOL_ID: 19;
SOURCE 91 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 92 ORGANISM_COMMON: HUMAN;
SOURCE 93 ORGANISM_TAXID: 9606;
SOURCE 94 CELL_LINE: HEK293;
SOURCE 95 MOL_ID: 20;
SOURCE 96 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 97 ORGANISM_COMMON: HUMAN;
SOURCE 98 ORGANISM_TAXID: 9606;
SOURCE 99 CELL_LINE: HEK293;
SOURCE 100 MOL_ID: 21;
SOURCE 101 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 102 ORGANISM_COMMON: HUMAN;
SOURCE 103 ORGANISM_TAXID: 9606;
SOURCE 104 CELL_LINE: HEK293;
SOURCE 105 MOL_ID: 22;
SOURCE 106 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 107 ORGANISM_COMMON: HUMAN;
SOURCE 108 ORGANISM_TAXID: 9606;
SOURCE 109 CELL_LINE: HEK293;
SOURCE 110 MOL_ID: 23;
SOURCE 111 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 112 ORGANISM_COMMON: HUMAN;
SOURCE 113 ORGANISM_TAXID: 9606;
SOURCE 114 CELL_LINE: HEK293;
SOURCE 115 MOL_ID: 24;
SOURCE 116 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 117 ORGANISM_COMMON: HUMAN;
SOURCE 118 ORGANISM_TAXID: 9606;
SOURCE 119 CELL_LINE: HEK293;
SOURCE 120 MOL_ID: 25;
SOURCE 121 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 122 ORGANISM_COMMON: HUMAN;
SOURCE 123 ORGANISM_TAXID: 9606;
SOURCE 124 CELL_LINE: HEK293;
SOURCE 125 MOL_ID: 26;
SOURCE 126 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 127 ORGANISM_COMMON: HUMAN;
SOURCE 128 ORGANISM_TAXID: 9606;
SOURCE 129 CELL_LINE: HEK293;
SOURCE 130 MOL_ID: 27;
SOURCE 131 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 132 ORGANISM_COMMON: HUMAN;
SOURCE 133 ORGANISM_TAXID: 9606;
SOURCE 134 CELL_LINE: HEK293;
SOURCE 135 MOL_ID: 28;
SOURCE 136 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 137 ORGANISM_COMMON: HUMAN;
SOURCE 138 ORGANISM_TAXID: 9606;
SOURCE 139 CELL_LINE: HEK293;
SOURCE 140 MOL_ID: 29;
SOURCE 141 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 142 ORGANISM_COMMON: HUMAN;
SOURCE 143 ORGANISM_TAXID: 9606;
SOURCE 144 CELL_LINE: HEK293;
SOURCE 145 MOL_ID: 30;
SOURCE 146 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 147 ORGANISM_COMMON: HUMAN;
SOURCE 148 ORGANISM_TAXID: 9606;
SOURCE 149 CELL_LINE: HEK293;
SOURCE 150 MOL_ID: 31;
SOURCE 151 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 152 ORGANISM_COMMON: HUMAN;
SOURCE 153 ORGANISM_TAXID: 9606;
SOURCE 154 CELL_LINE: HEK293;
SOURCE 155 MOL_ID: 32;
SOURCE 156 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 157 ORGANISM_COMMON: HUMAN;
SOURCE 158 ORGANISM_TAXID: 9606;
SOURCE 159 CELL_LINE: HEK293;
SOURCE 160 MOL_ID: 33;
SOURCE 161 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 162 ORGANISM_COMMON: HUMAN;
SOURCE 163 ORGANISM_TAXID: 9606;
SOURCE 164 CELL_LINE: HEK293;
SOURCE 165 MOL_ID: 34;
SOURCE 166 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 167 ORGANISM_COMMON: HUMAN;
SOURCE 168 ORGANISM_TAXID: 9606;
SOURCE 169 GENE: PNO1;
SOURCE 170 EXPRESSION_SYSTEM: ESCHERICHIA COLI K-12;
SOURCE 171 EXPRESSION_SYSTEM_TAXID: 83333;
SOURCE 172 MOL_ID: 35;
SOURCE 173 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 174 ORGANISM_COMMON: HUMAN;
SOURCE 175 ORGANISM_TAXID: 9606;
SOURCE 176 GENE: NOB1, ART4, NOB1P, PSMD8BP1, MSTP158;
SOURCE 177 EXPRESSION_SYSTEM: ESCHERICHIA COLI K-12;
SOURCE 178 EXPRESSION_SYSTEM_TAXID: 83333;
SOURCE 179 MOL_ID: 36;
SOURCE 180 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 181 ORGANISM_COMMON: HUMAN;
SOURCE 182 ORGANISM_TAXID: 9606;
SOURCE 183 GENE: RIOK1;
SOURCE 184 EXPRESSION_SYSTEM: ESCHERICHIA COLI K-12;
SOURCE 185 EXPRESSION_SYSTEM_TAXID: 83333
KEYWDS 40S, PRE-40S, RIBOSOME BIOGENESIS, RIBOSOME
EXPDTA ELECTRON MICROSCOPY
AUTHOR M.AMEISMEIER,J.CHENG,O.BERNINGHAUSEN,R.BECKMANN
REVDAT 4 11-DEC-19 6G5I 1 CRYST1 SCALE
REVDAT 3 27-JUN-18 6G5I 1 JRNL
REVDAT 2 20-JUN-18 6G5I 1 JRNL
REVDAT 1 06-JUN-18 6G5I 0
JRNL AUTH M.AMEISMEIER,J.CHENG,O.BERNINGHAUSEN,R.BECKMANN
JRNL TITL VISUALIZING LATE STATES OF HUMAN 40S RIBOSOMAL SUBUNIT
JRNL TITL 2 MATURATION.
JRNL REF NATURE V. 558 249 2018
JRNL REFN ISSN 0028-0836
JRNL PMID 29875412
JRNL DOI 10.1038/S41586-018-0193-0
REMARK 2
REMARK 2 RESOLUTION. 3.50 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : NULL
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.500
REMARK 3 NUMBER OF PARTICLES : 83883
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 6G5I COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 02-APR-18.
REMARK 100 THE DEPOSITION ID IS D_1200009424.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : CRYO-EM STRUCTURE OF A LATE
REMARK 245 HUMAN PRE-40S RIBOSOMAL SUBUNIT
REMARK 245 - STATE R
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.60
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : FEI FALCON II (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 2.50
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 36-MERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 36-MERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 201350 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 417600 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -1440.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: 2, A, B, C, D, E, F, G, H, I,
REMARK 350 AND CHAINS: J, K, L, M, N, O, P, Q, R,
REMARK 350 AND CHAINS: S, T, U, V, W, X, Y, Z, b, c,
REMARK 350 AND CHAINS: d, e, f, g, x, y, z
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 C 2 131
REMARK 465 U 2 132
REMARK 465 C 2 133
REMARK 465 C 2 134
REMARK 465 U 2 135
REMARK 465 C 2 136
REMARK 465 U 2 137
REMARK 465 C 2 138
REMARK 465 C 2 139
REMARK 465 A 2 226
REMARK 465 U 2 227
REMARK 465 C 2 228
REMARK 465 A 2 229
REMARK 465 A 2 230
REMARK 465 A 2 231
REMARK 465 A 2 232
REMARK 465 C 2 233
REMARK 465 C 2 234
REMARK 465 A 2 235
REMARK 465 A 2 236
REMARK 465 C 2 237
REMARK 465 C 2 238
REMARK 465 C 2 239
REMARK 465 G 2 240
REMARK 465 G 2 241
REMARK 465 U 2 242
REMARK 465 C 2 243
REMARK 465 A 2 244
REMARK 465 G 2 245
REMARK 465 C 2 246
REMARK 465 C 2 247
REMARK 465 C 2 248
REMARK 465 C 2 249
REMARK 465 U 2 250
REMARK 465 C 2 251
REMARK 465 U 2 252
REMARK 465 C 2 253
REMARK 465 C 2 254
REMARK 465 G 2 255
REMARK 465 G 2 256
REMARK 465 C 2 257
REMARK 465 C 2 258
REMARK 465 C 2 259
REMARK 465 C 2 260
REMARK 465 G 2 261
REMARK 465 G 2 262
REMARK 465 C 2 263
REMARK 465 C 2 264
REMARK 465 G 2 265
REMARK 465 G 2 266
REMARK 465 G 2 267
REMARK 465 G 2 268
REMARK 465 G 2 269
REMARK 465 G 2 270
REMARK 465 C 2 271
REMARK 465 G 2 272
REMARK 465 G 2 273
REMARK 465 G 2 274
REMARK 465 C 2 275
REMARK 465 G 2 276
REMARK 465 C 2 277
REMARK 465 C 2 278
REMARK 465 G 2 279
REMARK 465 G 2 280
REMARK 465 C 2 281
REMARK 465 G 2 282
REMARK 465 G 2 283
REMARK 465 C 2 284
REMARK 465 U 2 285
REMARK 465 U 2 286
REMARK 465 C 2 323
REMARK 465 C 2 324
REMARK 465 C 2 325
REMARK 465 C 2 326
REMARK 465 G 2 327
REMARK 465 U 2 328
REMARK 465 U 2 689
REMARK 465 G 2 690
REMARK 465 G 2 691
REMARK 465 G 2 692
REMARK 465 A 2 693
REMARK 465 G 2 694
REMARK 465 C 2 695
REMARK 465 G 2 696
REMARK 465 G 2 697
REMARK 465 G 2 698
REMARK 465 C 2 699
REMARK 465 G 2 700
REMARK 465 G 2 701
REMARK 465 G 2 702
REMARK 465 C 2 703
REMARK 465 G 2 704
REMARK 465 G 2 705
REMARK 465 U 2 706
REMARK 465 C 2 707
REMARK 465 C 2 708
REMARK 465 G 2 709
REMARK 465 C 2 710
REMARK 465 C 2 711
REMARK 465 G 2 712
REMARK 465 C 2 713
REMARK 465 G 2 714
REMARK 465 A 2 715
REMARK 465 G 2 716
REMARK 465 G 2 717
REMARK 465 C 2 718
REMARK 465 G 2 719
REMARK 465 A 2 720
REMARK 465 G 2 721
REMARK 465 C 2 722
REMARK 465 C 2 723
REMARK 465 A 2 724
REMARK 465 C 2 725
REMARK 465 C 2 726
REMARK 465 G 2 727
REMARK 465 C 2 728
REMARK 465 C 2 729
REMARK 465 C 2 730
REMARK 465 G 2 731
REMARK 465 U 2 732
REMARK 465 C 2 733
REMARK 465 C 2 734
REMARK 465 C 2 735
REMARK 465 C 2 736
REMARK 465 G 2 737
REMARK 465 C 2 738
REMARK 465 C 2 739
REMARK 465 C 2 740
REMARK 465 C 2 741
REMARK 465 U 2 742
REMARK 465 U 2 743
REMARK 465 G 2 744
REMARK 465 C 2 745
REMARK 465 C 2 753
REMARK 465 G 2 754
REMARK 465 C 2 755
REMARK 465 C 2 756
REMARK 465 C 2 757
REMARK 465 C 2 758
REMARK 465 C 2 759
REMARK 465 U 2 760
REMARK 465 C 2 761
REMARK 465 G 2 762
REMARK 465 A 2 763
REMARK 465 U 2 764
REMARK 465 G 2 765
REMARK 465 C 2 766
REMARK 465 U 2 767
REMARK 465 C 2 768
REMARK 465 U 2 769
REMARK 465 U 2 770
REMARK 465 A 2 771
REMARK 465 G 2 772
REMARK 465 C 2 773
REMARK 465 U 2 774
REMARK 465 G 2 775
REMARK 465 A 2 776
REMARK 465 G 2 777
REMARK 465 U 2 778
REMARK 465 G 2 779
REMARK 465 U 2 780
REMARK 465 C 2 781
REMARK 465 C 2 782
REMARK 465 C 2 783
REMARK 465 G 2 784
REMARK 465 C 2 785
REMARK 465 G 2 786
REMARK 465 G 2 787
REMARK 465 G 2 788
REMARK 465 G 2 789
REMARK 465 C 2 790
REMARK 465 C 2 835
REMARK 465 G 2 836
REMARK 465 A 2 837
REMARK 465 G 2 838
REMARK 465 C 2 839
REMARK 465 C 2 840
REMARK 465 C 2 1417
REMARK 465 C 2 1418
REMARK 465 C 2 1419
REMARK 465 G 2 1420
REMARK 465 A 2 1421
REMARK 465 G 2 1422
REMARK 465 C 2 1423
REMARK 465 C 2 1433
REMARK 465 C 2 1434
REMARK 465 C 2 1435
REMARK 465 C 2 1436
REMARK 465 C 2 1437
REMARK 465 G 2 1552
REMARK 465 C 2 1553
REMARK 465 C 2 1554
REMARK 465 U 2 1555
REMARK 465 A 2 1556
REMARK 465 C 2 1557
REMARK 465 A 2 1699
REMARK 465 C 2 1700
REMARK 465 C 2 1701
REMARK 465 C 2 1762
REMARK 465 G 2 1763
REMARK 465 G 2 1764
REMARK 465 C 2 1765
REMARK 465 C 2 1766
REMARK 465 C 2 1767
REMARK 465 A 2 1768
REMARK 465 C 2 1769
REMARK 465 G 2 1770
REMARK 465 A 2 1834
REMARK 465 A 2 1835
REMARK 465 G 2 1836
REMARK 465 G 2 1837
REMARK 465 U 2 1838
REMARK 465 A 2 1870
REMARK 465 C 2 1871
REMARK 465 G 2 1872
REMARK 465 G 2 1873
REMARK 465 A 2 1874
REMARK 465 G 2 1875
REMARK 465 C 2 1876
REMARK 465 C 2 1877
REMARK 465 C 2 1878
REMARK 465 G 2 1879
REMARK 465 G 2 1880
REMARK 465 A 2 1881
REMARK 465 G 2 1882
REMARK 465 MET A 1
REMARK 465 ALA A 218
REMARK 465 GLU A 219
REMARK 465 LYS A 220
REMARK 465 ALA A 221
REMARK 465 VAL A 222
REMARK 465 THR A 223
REMARK 465 LYS A 224
REMARK 465 GLU A 225
REMARK 465 GLU A 226
REMARK 465 PHE A 227
REMARK 465 GLN A 228
REMARK 465 GLY A 229
REMARK 465 GLU A 230
REMARK 465 TRP A 231
REMARK 465 THR A 232
REMARK 465 ALA A 233
REMARK 465 PRO A 234
REMARK 465 ALA A 235
REMARK 465 PRO A 236
REMARK 465 GLU A 237
REMARK 465 PHE A 238
REMARK 465 THR A 239
REMARK 465 ALA A 240
REMARK 465 THR A 241
REMARK 465 GLN A 242
REMARK 465 PRO A 243
REMARK 465 GLU A 244
REMARK 465 VAL A 245
REMARK 465 ALA A 246
REMARK 465 ASP A 247
REMARK 465 TRP A 248
REMARK 465 SER A 249
REMARK 465 GLU A 250
REMARK 465 GLY A 251
REMARK 465 VAL A 252
REMARK 465 GLN A 253
REMARK 465 VAL A 254
REMARK 465 PRO A 255
REMARK 465 SER A 256
REMARK 465 VAL A 257
REMARK 465 PRO A 258
REMARK 465 ILE A 259
REMARK 465 GLN A 260
REMARK 465 GLN A 261
REMARK 465 PHE A 262
REMARK 465 PRO A 263
REMARK 465 THR A 264
REMARK 465 GLU A 265
REMARK 465 ASP A 266
REMARK 465 TRP A 267
REMARK 465 SER A 268
REMARK 465 ALA A 269
REMARK 465 GLN A 270
REMARK 465 PRO A 271
REMARK 465 ALA A 272
REMARK 465 THR A 273
REMARK 465 GLU A 274
REMARK 465 ASP A 275
REMARK 465 TRP A 276
REMARK 465 SER A 277
REMARK 465 ALA A 278
REMARK 465 ALA A 279
REMARK 465 PRO A 280
REMARK 465 THR A 281
REMARK 465 ALA A 282
REMARK 465 GLN A 283
REMARK 465 ALA A 284
REMARK 465 THR A 285
REMARK 465 GLU A 286
REMARK 465 TRP A 287
REMARK 465 VAL A 288
REMARK 465 GLY A 289
REMARK 465 ALA A 290
REMARK 465 THR A 291
REMARK 465 THR A 292
REMARK 465 ASP A 293
REMARK 465 TRP A 294
REMARK 465 SER A 295
REMARK 465 MET B 1
REMARK 465 ALA B 2
REMARK 465 VAL B 3
REMARK 465 GLY B 4
REMARK 465 LYS B 5
REMARK 465 ASN B 6
REMARK 465 LYS B 7
REMARK 465 ARG B 8
REMARK 465 LEU B 9
REMARK 465 THR B 10
REMARK 465 LYS B 11
REMARK 465 GLY B 12
REMARK 465 GLY B 13
REMARK 465 LYS B 14
REMARK 465 LYS B 15
REMARK 465 GLY B 16
REMARK 465 ALA B 17
REMARK 465 LYS B 18
REMARK 465 LYS B 19
REMARK 465 LYS B 20
REMARK 465 GLU B 234
REMARK 465 GLY B 235
REMARK 465 SER B 236
REMARK 465 SER B 237
REMARK 465 SER B 238
REMARK 465 GLY B 239
REMARK 465 LYS B 240
REMARK 465 ALA B 241
REMARK 465 THR B 242
REMARK 465 GLY B 243
REMARK 465 ASP B 244
REMARK 465 GLU B 245
REMARK 465 THR B 246
REMARK 465 GLY B 247
REMARK 465 ALA B 248
REMARK 465 LYS B 249
REMARK 465 VAL B 250
REMARK 465 GLU B 251
REMARK 465 ARG B 252
REMARK 465 ALA B 253
REMARK 465 ASP B 254
REMARK 465 GLY B 255
REMARK 465 TYR B 256
REMARK 465 GLU B 257
REMARK 465 PRO B 258
REMARK 465 PRO B 259
REMARK 465 VAL B 260
REMARK 465 GLN B 261
REMARK 465 GLU B 262
REMARK 465 SER B 263
REMARK 465 VAL B 264
REMARK 465 MET C 1
REMARK 465 ALA C 2
REMARK 465 ASP C 3
REMARK 465 ASP C 4
REMARK 465 ALA C 5
REMARK 465 GLY C 6
REMARK 465 ALA C 7
REMARK 465 ALA C 8
REMARK 465 GLY C 9
REMARK 465 GLY C 10
REMARK 465 PRO C 11
REMARK 465 GLY C 12
REMARK 465 GLY C 13
REMARK 465 PRO C 14
REMARK 465 GLY C 15
REMARK 465 GLY C 16
REMARK 465 PRO C 17
REMARK 465 GLY C 18
REMARK 465 MET C 19
REMARK 465 GLY C 20
REMARK 465 ASN C 21
REMARK 465 ARG C 22
REMARK 465 GLY C 23
REMARK 465 GLY C 24
REMARK 465 PHE C 25
REMARK 465 ARG C 26
REMARK 465 GLY C 27
REMARK 465 GLY C 28
REMARK 465 PHE C 29
REMARK 465 GLY C 30
REMARK 465 SER C 31
REMARK 465 GLY C 32
REMARK 465 ILE C 33
REMARK 465 ARG C 34
REMARK 465 GLY C 35
REMARK 465 ARG C 36
REMARK 465 GLY C 37
REMARK 465 ARG C 38
REMARK 465 GLY C 39
REMARK 465 ARG C 40
REMARK 465 GLY C 41
REMARK 465 ARG C 42
REMARK 465 GLY C 43
REMARK 465 ARG C 44
REMARK 465 GLY C 45
REMARK 465 ARG C 46
REMARK 465 GLY C 47
REMARK 465 ARG C 48
REMARK 465 GLY C 49
REMARK 465 ALA C 50
REMARK 465 ARG C 51
REMARK 465 GLY C 52
REMARK 465 GLY C 53
REMARK 465 LYS C 54
REMARK 465 ALA C 55
REMARK 465 GLU C 56
REMARK 465 ASP C 57
REMARK 465 LYS C 58
REMARK 465 HIS C 277
REMARK 465 THR C 278
REMARK 465 ARG C 279
REMARK 465 VAL C 280
REMARK 465 SER C 281
REMARK 465 VAL C 282
REMARK 465 GLN C 283
REMARK 465 ARG C 284
REMARK 465 THR C 285
REMARK 465 GLN C 286
REMARK 465 ALA C 287
REMARK 465 PRO C 288
REMARK 465 ALA C 289
REMARK 465 VAL C 290
REMARK 465 ALA C 291
REMARK 465 THR C 292
REMARK 465 THR C 293
REMARK 465 MET D 1
REMARK 465 ALA D 2
REMARK 465 GLY D 228
REMARK 465 GLY D 229
REMARK 465 LYS D 230
REMARK 465 PRO D 231
REMARK 465 GLU D 232
REMARK 465 PRO D 233
REMARK 465 PRO D 234
REMARK 465 ALA D 235
REMARK 465 MET D 236
REMARK 465 PRO D 237
REMARK 465 GLN D 238
REMARK 465 PRO D 239
REMARK 465 VAL D 240
REMARK 465 PRO D 241
REMARK 465 THR D 242
REMARK 465 ALA D 243
REMARK 465 MET E 1
REMARK 465 MET F 1
REMARK 465 THR F 2
REMARK 465 GLU F 3
REMARK 465 TRP F 4
REMARK 465 GLU F 5
REMARK 465 THR F 6
REMARK 465 ALA F 7
REMARK 465 ALA F 8
REMARK 465 PRO F 9
REMARK 465 ALA F 10
REMARK 465 VAL F 11
REMARK 465 ALA F 12
REMARK 465 GLU F 13
REMARK 465 THR F 14
REMARK 465 PRO F 15
REMARK 465 ARG G 231
REMARK 465 ARG G 232
REMARK 465 ARG G 233
REMARK 465 LEU G 234
REMARK 465 SER G 235
REMARK 465 SER G 236
REMARK 465 LEU G 237
REMARK 465 ARG G 238
REMARK 465 ALA G 239
REMARK 465 SER G 240
REMARK 465 THR G 241
REMARK 465 SER G 242
REMARK 465 LYS G 243
REMARK 465 SER G 244
REMARK 465 GLU G 245
REMARK 465 SER G 246
REMARK 465 SER G 247
REMARK 465 GLN G 248
REMARK 465 LYS G 249
REMARK 465 MET H 1
REMARK 465 PHE H 2
REMARK 465 SER H 3
REMARK 465 SER H 4
REMARK 465 SER H 5
REMARK 465 ALA H 6
REMARK 465 LYS H 7
REMARK 465 LEU H 194
REMARK 465 MET I 1
REMARK 465 GLY I 207
REMARK 465 LYS I 208
REMARK 465 MET J 1
REMARK 465 GLN J 182
REMARK 465 GLY J 183
REMARK 465 GLY J 184
REMARK 465 ALA J 185
REMARK 465 GLY J 186
REMARK 465 ALA J 187
REMARK 465 GLY J 188
REMARK 465 ASP J 189
REMARK 465 ASP J 190
REMARK 465 GLU J 191
REMARK 465 GLU J 192
REMARK 465 GLU J 193
REMARK 465 ASP J 194
REMARK 465 MET K 1
REMARK 465 LEU K 2
REMARK 465 ARG K 98
REMARK 465 PRO K 99
REMARK 465 GLU K 100
REMARK 465 THR K 101
REMARK 465 GLY K 102
REMARK 465 ARG K 103
REMARK 465 PRO K 104
REMARK 465 ARG K 105
REMARK 465 PRO K 106
REMARK 465 LYS K 107
REMARK 465 GLY K 108
REMARK 465 LEU K 109
REMARK 465 GLU K 110
REMARK 465 GLY K 111
REMARK 465 GLU K 112
REMARK 465 ARG K 113
REMARK 465 PRO K 114
REMARK 465 ALA K 115
REMARK 465 ARG K 116
REMARK 465 LEU K 117
REMARK 465 THR K 118
REMARK 465 ARG K 119
REMARK 465 GLY K 120
REMARK 465 GLU K 121
REMARK 465 ALA K 122
REMARK 465 ASP K 123
REMARK 465 ARG K 124
REMARK 465 ASP K 125
REMARK 465 THR K 126
REMARK 465 TYR K 127
REMARK 465 ARG K 128
REMARK 465 ARG K 129
REMARK 465 SER K 130
REMARK 465 ALA K 131
REMARK 465 VAL K 132
REMARK 465 PRO K 133
REMARK 465 PRO K 134
REMARK 465 GLY K 135
REMARK 465 ALA K 136
REMARK 465 ASP K 137
REMARK 465 LYS K 138
REMARK 465 LYS K 139
REMARK 465 ALA K 140
REMARK 465 GLU K 141
REMARK 465 ALA K 142
REMARK 465 GLY K 143
REMARK 465 ALA K 144
REMARK 465 GLY K 145
REMARK 465 SER K 146
REMARK 465 ALA K 147
REMARK 465 THR K 148
REMARK 465 GLU K 149
REMARK 465 PHE K 150
REMARK 465 GLN K 151
REMARK 465 PHE K 152
REMARK 465 ARG K 153
REMARK 465 GLY K 154
REMARK 465 GLY K 155
REMARK 465 PHE K 156
REMARK 465 GLY K 157
REMARK 465 ARG K 158
REMARK 465 GLY K 159
REMARK 465 ARG K 160
REMARK 465 GLY K 161
REMARK 465 GLN K 162
REMARK 465 PRO K 163
REMARK 465 PRO K 164
REMARK 465 GLN K 165
REMARK 465 MET L 1
REMARK 465 LYS L 153
REMARK 465 GLN L 154
REMARK 465 PHE L 155
REMARK 465 GLN L 156
REMARK 465 LYS L 157
REMARK 465 PHE L 158
REMARK 465 MET M 1
REMARK 465 ALA M 2
REMARK 465 GLU M 3
REMARK 465 GLU M 4
REMARK 465 GLY M 5
REMARK 465 ILE M 6
REMARK 465 ALA M 7
REMARK 465 ALA M 8
REMARK 465 GLY M 9
REMARK 465 MET N 1
REMARK 465 ALA N 151
REMARK 465 MET O 1
REMARK 465 ALA O 2
REMARK 465 PRO O 3
REMARK 465 ARG O 4
REMARK 465 LYS O 5
REMARK 465 GLY O 6
REMARK 465 LYS O 7
REMARK 465 GLU O 8
REMARK 465 LYS O 9
REMARK 465 LYS O 10
REMARK 465 GLU O 11
REMARK 465 GLU O 12
REMARK 465 GLN O 13
REMARK 465 VAL O 14
REMARK 465 ILE O 15
REMARK 465 SER O 16
REMARK 465 MET P 1
REMARK 465 ALA P 2
REMARK 465 GLU P 3
REMARK 465 VAL P 4
REMARK 465 GLU P 5
REMARK 465 GLN P 6
REMARK 465 LYS P 7
REMARK 465 LYS P 8
REMARK 465 LYS P 9
REMARK 465 ARG P 10
REMARK 465 THR P 11
REMARK 465 PHE P 12
REMARK 465 ARG P 13
REMARK 465 LYS P 14
REMARK 465 ALA P 135
REMARK 465 THR P 136
REMARK 465 HIS P 137
REMARK 465 SER P 138
REMARK 465 SER P 139
REMARK 465 ARG P 140
REMARK 465 PHE P 141
REMARK 465 ILE P 142
REMARK 465 PRO P 143
REMARK 465 LEU P 144
REMARK 465 LYS P 145
REMARK 465 MET Q 1
REMARK 465 PRO Q 2
REMARK 465 SER Q 3
REMARK 465 LYS Q 4
REMARK 465 GLY Q 5
REMARK 465 PRO Q 6
REMARK 465 LEU Q 7
REMARK 465 MET R 1
REMARK 465 VAL R 124
REMARK 465 GLY R 125
REMARK 465 MET R 126
REMARK 465 ASN R 127
REMARK 465 PHE R 128
REMARK 465 LYS R 129
REMARK 465 THR R 130
REMARK 465 PRO R 131
REMARK 465 ARG R 132
REMARK 465 GLY R 133
REMARK 465 PRO R 134
REMARK 465 VAL R 135
REMARK 465 MET S 1
REMARK 465 SER S 2
REMARK 465 VAL S 146
REMARK 465 GLY S 147
REMARK 465 VAL S 148
REMARK 465 SER S 149
REMARK 465 LYS S 150
REMARK 465 LYS S 151
REMARK 465 LYS S 152
REMARK 465 MET T 1
REMARK 465 MET U 1
REMARK 465 ALA U 2
REMARK 465 PHE U 3
REMARK 465 LYS U 4
REMARK 465 ASP U 5
REMARK 465 THR U 6
REMARK 465 GLY U 7
REMARK 465 LYS U 8
REMARK 465 THR U 9
REMARK 465 PRO U 10
REMARK 465 VAL U 11
REMARK 465 GLU U 12
REMARK 465 PRO U 13
REMARK 465 GLU U 14
REMARK 465 VAL U 15
REMARK 465 ALA U 16
REMARK 465 ASP U 118
REMARK 465 ALA U 119
REMARK 465 PHE V 83
REMARK 465 MET W 1
REMARK 465 MET X 1
REMARK 465 SER X 143
REMARK 465 MET Y 1
REMARK 465 ASN Y 2
REMARK 465 ALA Y 127
REMARK 465 GLY Y 128
REMARK 465 LYS Y 129
REMARK 465 LYS Y 130
REMARK 465 PRO Y 131
REMARK 465 LYS Y 132
REMARK 465 GLU Y 133
REMARK 465 MET Z 1
REMARK 465 PRO Z 2
REMARK 465 PRO Z 3
REMARK 465 LYS Z 4
REMARK 465 ASP Z 5
REMARK 465 ASP Z 6
REMARK 465 LYS Z 7
REMARK 465 LYS Z 8
REMARK 465 LYS Z 9
REMARK 465 LYS Z 10
REMARK 465 ASP Z 11
REMARK 465 ALA Z 12
REMARK 465 GLY Z 13
REMARK 465 LYS Z 14
REMARK 465 SER Z 15
REMARK 465 ALA Z 16
REMARK 465 LYS Z 17
REMARK 465 LYS Z 18
REMARK 465 ASP Z 19
REMARK 465 LYS Z 20
REMARK 465 ASP Z 21
REMARK 465 PRO Z 22
REMARK 465 VAL Z 23
REMARK 465 ASN Z 24
REMARK 465 LYS Z 25
REMARK 465 SER Z 26
REMARK 465 GLY Z 27
REMARK 465 GLY Z 28
REMARK 465 LYS Z 29
REMARK 465 ALA Z 30
REMARK 465 LYS Z 31
REMARK 465 LYS Z 32
REMARK 465 LYS Z 33
REMARK 465 LYS Z 34
REMARK 465 TRP Z 35
REMARK 465 SER Z 36
REMARK 465 LYS Z 37
REMARK 465 GLY Z 38
REMARK 465 LYS Z 39
REMARK 465 VAL Z 40
REMARK 465 ARG Z 41
REMARK 465 LYS Z 114
REMARK 465 GLY Z 115
REMARK 465 GLY Z 116
REMARK 465 ASP Z 117
REMARK 465 ALA Z 118
REMARK 465 PRO Z 119
REMARK 465 ALA Z 120
REMARK 465 ALA Z 121
REMARK 465 GLY Z 122
REMARK 465 GLU Z 123
REMARK 465 ASP Z 124
REMARK 465 ALA Z 125
REMARK 465 MET b 1
REMARK 465 HIS b 84
REMARK 465 MET c 1
REMARK 465 ASP c 2
REMARK 465 THR c 3
REMARK 465 SER c 4
REMARK 465 ARG c 5
REMARK 465 VAL c 6
REMARK 465 GLN c 7
REMARK 465 ARG c 69
REMARK 465 MET d 1
REMARK 465 LYS e 1
REMARK 465 VAL e 2
REMARK 465 HIS e 3
REMARK 465 MET f 1
REMARK 465 GLN f 2
REMARK 465 ILE f 3
REMARK 465 PHE f 4
REMARK 465 VAL f 5
REMARK 465 LYS f 6
REMARK 465 THR f 7
REMARK 465 LEU f 8
REMARK 465 THR f 9
REMARK 465 GLY f 10
REMARK 465 LYS f 11
REMARK 465 THR f 12
REMARK 465 ILE f 13
REMARK 465 THR f 14
REMARK 465 LEU f 15
REMARK 465 GLU f 16
REMARK 465 VAL f 17
REMARK 465 GLU f 18
REMARK 465 PRO f 19
REMARK 465 SER f 20
REMARK 465 ASP f 21
REMARK 465 THR f 22
REMARK 465 ILE f 23
REMARK 465 GLU f 24
REMARK 465 ASN f 25
REMARK 465 VAL f 26
REMARK 465 LYS f 27
REMARK 465 ALA f 28
REMARK 465 LYS f 29
REMARK 465 ILE f 30
REMARK 465 GLN f 31
REMARK 465 ASP f 32
REMARK 465 LYS f 33
REMARK 465 GLU f 34
REMARK 465 GLY f 35
REMARK 465 ILE f 36
REMARK 465 PRO f 37
REMARK 465 PRO f 38
REMARK 465 ASP f 39
REMARK 465 GLN f 40
REMARK 465 GLN f 41
REMARK 465 ARG f 42
REMARK 465 LEU f 43
REMARK 465 ILE f 44
REMARK 465 PHE f 45
REMARK 465 ALA f 46
REMARK 465 GLY f 47
REMARK 465 LYS f 48
REMARK 465 GLN f 49
REMARK 465 LEU f 50
REMARK 465 GLU f 51
REMARK 465 ASP f 52
REMARK 465 GLY f 53
REMARK 465 ARG f 54
REMARK 465 THR f 55
REMARK 465 LEU f 56
REMARK 465 SER f 57
REMARK 465 ASP f 58
REMARK 465 TYR f 59
REMARK 465 ASN f 60
REMARK 465 ILE f 61
REMARK 465 GLN f 62
REMARK 465 LYS f 63
REMARK 465 GLU f 64
REMARK 465 SER f 65
REMARK 465 THR f 66
REMARK 465 LEU f 67
REMARK 465 HIS f 68
REMARK 465 LEU f 69
REMARK 465 VAL f 70
REMARK 465 LEU f 71
REMARK 465 ARG f 72
REMARK 465 LEU f 73
REMARK 465 ARG f 74
REMARK 465 GLY f 75
REMARK 465 GLY f 76
REMARK 465 ALA f 77
REMARK 465 LYS f 78
REMARK 465 LYS f 79
REMARK 465 ARG f 80
REMARK 465 LYS f 81
REMARK 465 LYS f 82
REMARK 465 LYS f 83
REMARK 465 SER f 84
REMARK 465 CYS f 85
REMARK 465 THR f 86
REMARK 465 PHE f 150
REMARK 465 ASN f 151
REMARK 465 LYS f 152
REMARK 465 PRO f 153
REMARK 465 GLU f 154
REMARK 465 ASP f 155
REMARK 465 LYS f 156
REMARK 465 MET g 1
REMARK 465 THR g 316
REMARK 465 ARG g 317
REMARK 465 MET x 1
REMARK 465 GLU x 2
REMARK 465 SER x 3
REMARK 465 GLU x 4
REMARK 465 MET x 5
REMARK 465 GLU x 6
REMARK 465 THR x 7
REMARK 465 GLN x 8
REMARK 465 SER x 9
REMARK 465 ALA x 10
REMARK 465 ARG x 11
REMARK 465 ALA x 12
REMARK 465 GLU x 13
REMARK 465 GLU x 14
REMARK 465 GLY x 15
REMARK 465 PHE x 16
REMARK 465 THR x 17
REMARK 465 GLN x 18
REMARK 465 VAL x 19
REMARK 465 THR x 20
REMARK 465 ARG x 21
REMARK 465 LYS x 22
REMARK 465 GLY x 23
REMARK 465 GLY x 24
REMARK 465 ARG x 25
REMARK 465 ARG x 26
REMARK 465 ALA x 27
REMARK 465 LYS x 28
REMARK 465 LYS x 29
REMARK 465 ARG x 30
REMARK 465 GLN x 31
REMARK 465 ALA x 32
REMARK 465 GLU x 33
REMARK 465 GLN x 34
REMARK 465 LEU x 35
REMARK 465 SER x 36
REMARK 465 ALA x 37
REMARK 465 ALA x 38
REMARK 465 GLY x 39
REMARK 465 GLU x 40
REMARK 465 GLY x 41
REMARK 465 GLY x 42
REMARK 465 ASP x 43
REMARK 465 ALA x 44
REMARK 465 GLY x 45
REMARK 465 ARG x 46
REMARK 465 MET x 47
REMARK 465 ASP x 48
REMARK 465 THR x 49
REMARK 465 GLU x 50
REMARK 465 GLU x 51
REMARK 465 ALA x 52
REMARK 465 ARG x 53
REMARK 465 PRO x 54
REMARK 465 ALA x 55
REMARK 465 LYS x 56
REMARK 465 ARG x 57
REMARK 465 PRO x 58
REMARK 465 VAL x 59
REMARK 465 PHE x 60
REMARK 465 PRO x 61
REMARK 465 PRO x 62
REMARK 465 LEU x 63
REMARK 465 CYS x 64
REMARK 465 GLY x 65
REMARK 465 ASP x 66
REMARK 465 GLY x 67
REMARK 465 LEU x 68
REMARK 465 LEU x 69
REMARK 465 SER x 70
REMARK 465 GLY x 71
REMARK 465 LYS x 72
REMARK 465 SER x 248
REMARK 465 ALA x 249
REMARK 465 ASP x 250
REMARK 465 ARG x 251
REMARK 465 PHE x 252
REMARK 465 MET y 1
REMARK 465 ALA y 2
REMARK 465 PRO y 3
REMARK 465 VAL y 4
REMARK 465 GLU y 5
REMARK 465 HIS y 6
REMARK 465 PRO y 131
REMARK 465 TYR y 132
REMARK 465 LYS y 133
REMARK 465 PRO y 134
REMARK 465 LYS y 135
REMARK 465 PRO y 136
REMARK 465 PRO y 137
REMARK 465 GLN y 138
REMARK 465 GLU y 139
REMARK 465 THR y 140
REMARK 465 GLU y 141
REMARK 465 LYS y 142
REMARK 465 GLY y 143
REMARK 465 HIS y 144
REMARK 465 SER y 145
REMARK 465 ALA y 146
REMARK 465 CYS y 147
REMARK 465 GLU y 148
REMARK 465 PRO y 149
REMARK 465 GLU y 150
REMARK 465 ASN y 151
REMARK 465 LEU y 152
REMARK 465 GLU y 153
REMARK 465 PHE y 154
REMARK 465 SER y 155
REMARK 465 SER y 156
REMARK 465 PHE y 157
REMARK 465 MET y 158
REMARK 465 PHE y 159
REMARK 465 TRP y 160
REMARK 465 ARG y 161
REMARK 465 ASN y 162
REMARK 465 PRO y 163
REMARK 465 LEU y 164
REMARK 465 PRO y 165
REMARK 465 ASN y 166
REMARK 465 ILE y 167
REMARK 465 ASP y 168
REMARK 465 HIS y 169
REMARK 465 GLU y 170
REMARK 465 LEU y 171
REMARK 465 GLN y 172
REMARK 465 GLU y 173
REMARK 465 LEU y 174
REMARK 465 LEU y 175
REMARK 465 ILE y 176
REMARK 465 ASP y 177
REMARK 465 ARG y 178
REMARK 465 GLY y 179
REMARK 465 GLU y 180
REMARK 465 ASP y 181
REMARK 465 VAL y 182
REMARK 465 PRO y 183
REMARK 465 SER y 184
REMARK 465 GLU y 185
REMARK 465 GLU y 186
REMARK 465 GLU y 187
REMARK 465 GLU y 188
REMARK 465 GLU y 189
REMARK 465 GLU y 190
REMARK 465 GLU y 191
REMARK 465 ASN y 192
REMARK 465 GLY y 193
REMARK 465 PHE y 194
REMARK 465 GLU y 195
REMARK 465 ASP y 196
REMARK 465 ARG y 197
REMARK 465 LYS y 198
REMARK 465 ASP y 199
REMARK 465 ASP y 200
REMARK 465 SER y 201
REMARK 465 ASP y 202
REMARK 465 ASP y 203
REMARK 465 ASP y 204
REMARK 465 GLY y 205
REMARK 465 GLN y 218
REMARK 465 GLN y 219
REMARK 465 GLU y 220
REMARK 465 LEU y 221
REMARK 465 GLU y 222
REMARK 465 GLN y 223
REMARK 465 CYS y 224
REMARK 465 ASP y 225
REMARK 465 VAL y 226
REMARK 465 PRO y 227
REMARK 465 GLU y 228
REMARK 465 ASP y 229
REMARK 465 VAL y 230
REMARK 465 ARG y 231
REMARK 465 MET z 1
REMARK 465 ASP z 2
REMARK 465 TYR z 3
REMARK 465 ARG z 4
REMARK 465 ARG z 5
REMARK 465 LEU z 6
REMARK 465 LEU z 7
REMARK 465 MET z 8
REMARK 465 SER z 9
REMARK 465 ARG z 10
REMARK 465 VAL z 11
REMARK 465 VAL z 12
REMARK 465 PRO z 13
REMARK 465 GLY z 14
REMARK 465 GLN z 15
REMARK 465 PHE z 16
REMARK 465 ASP z 17
REMARK 465 ASP z 18
REMARK 465 ALA z 19
REMARK 465 ASP z 20
REMARK 465 SER z 21
REMARK 465 SER z 22
REMARK 465 ASP z 23
REMARK 465 SER z 24
REMARK 465 GLU z 25
REMARK 465 ASN z 26
REMARK 465 ARG z 27
REMARK 465 ASP z 28
REMARK 465 LEU z 29
REMARK 465 LYS z 30
REMARK 465 THR z 31
REMARK 465 VAL z 32
REMARK 465 LYS z 33
REMARK 465 GLU z 34
REMARK 465 LYS z 35
REMARK 465 ASP z 36
REMARK 465 ASP z 37
REMARK 465 ILE z 38
REMARK 465 LEU z 39
REMARK 465 PHE z 40
REMARK 465 GLU z 41
REMARK 465 ASP z 42
REMARK 465 LEU z 43
REMARK 465 GLN z 44
REMARK 465 ASP z 45
REMARK 465 ASN z 46
REMARK 465 VAL z 47
REMARK 465 ASN z 48
REMARK 465 GLU z 49
REMARK 465 ASN z 50
REMARK 465 GLY z 51
REMARK 465 GLU z 52
REMARK 465 GLY z 53
REMARK 465 GLU z 54
REMARK 465 ILE z 55
REMARK 465 GLU z 56
REMARK 465 ASP z 57
REMARK 465 GLU z 58
REMARK 465 GLU z 59
REMARK 465 GLU z 60
REMARK 465 GLU z 61
REMARK 465 GLY z 62
REMARK 465 TYR z 63
REMARK 465 ASP z 64
REMARK 465 ASP z 65
REMARK 465 ASP z 66
REMARK 465 ASP z 67
REMARK 465 ASP z 68
REMARK 465 ASP z 69
REMARK 465 TRP z 70
REMARK 465 ASP z 71
REMARK 465 TRP z 72
REMARK 465 ASP z 73
REMARK 465 GLU z 74
REMARK 465 GLY z 75
REMARK 465 VAL z 76
REMARK 465 GLY z 77
REMARK 465 LYS z 78
REMARK 465 LEU z 79
REMARK 465 ALA z 80
REMARK 465 LYS z 81
REMARK 465 GLY z 82
REMARK 465 TYR z 83
REMARK 465 VAL z 84
REMARK 465 TRP z 85
REMARK 465 ASN z 86
REMARK 465 GLY z 87
REMARK 465 GLY z 88
REMARK 465 SER z 89
REMARK 465 ASN z 90
REMARK 465 PRO z 91
REMARK 465 GLN z 92
REMARK 465 ALA z 93
REMARK 465 ASN z 94
REMARK 465 ARG z 95
REMARK 465 GLN z 96
REMARK 465 THR z 97
REMARK 465 SER z 98
REMARK 465 ASP z 99
REMARK 465 SER z 100
REMARK 465 SER z 101
REMARK 465 SER z 102
REMARK 465 ALA z 103
REMARK 465 LYS z 104
REMARK 465 MET z 105
REMARK 465 SER z 106
REMARK 465 THR z 107
REMARK 465 PRO z 108
REMARK 465 ALA z 109
REMARK 465 ASP z 110
REMARK 465 LYS z 111
REMARK 465 VAL z 112
REMARK 465 LEU z 113
REMARK 465 ARG z 114
REMARK 465 LYS z 115
REMARK 465 PHE z 116
REMARK 465 GLU z 117
REMARK 465 ASN z 118
REMARK 465 LYS z 119
REMARK 465 ILE z 120
REMARK 465 ASN z 121
REMARK 465 LEU z 122
REMARK 465 ASP z 123
REMARK 465 LYS z 124
REMARK 465 LEU z 125
REMARK 465 ASN z 126
REMARK 465 VAL z 127
REMARK 465 THR z 128
REMARK 465 ASP z 129
REMARK 465 SER z 130
REMARK 465 VAL z 131
REMARK 465 ILE z 132
REMARK 465 ASN z 133
REMARK 465 LYS z 134
REMARK 465 VAL z 135
REMARK 465 THR z 136
REMARK 465 GLU z 137
REMARK 465 LYS z 138
REMARK 465 SER z 139
REMARK 465 ARG z 140
REMARK 465 GLN z 141
REMARK 465 LYS z 142
REMARK 465 GLU z 143
REMARK 465 ALA z 144
REMARK 465 ASP z 145
REMARK 465 MET z 146
REMARK 465 TYR z 147
REMARK 465 ARG z 148
REMARK 465 ILE z 149
REMARK 465 LYS z 150
REMARK 465 ASP z 151
REMARK 465 LYS z 152
REMARK 465 ALA z 153
REMARK 465 ASP z 154
REMARK 465 ARG z 155
REMARK 465 ALA z 156
REMARK 465 THR z 157
REMARK 465 VAL z 158
REMARK 465 GLU z 159
REMARK 465 GLN z 160
REMARK 465 VAL z 161
REMARK 465 LEU z 162
REMARK 465 ASP z 163
REMARK 465 PRO z 164
REMARK 465 ARG z 165
REMARK 465 THR z 166
REMARK 465 ARG z 167
REMARK 465 MET z 168
REMARK 465 ILE z 169
REMARK 465 LEU z 170
REMARK 465 PHE z 171
REMARK 465 LYS z 172
REMARK 465 MET z 173
REMARK 465 LEU z 174
REMARK 465 THR z 175
REMARK 465 ARG z 176
REMARK 465 GLY z 177
REMARK 465 ILE z 178
REMARK 465 ILE z 179
REMARK 465 THR z 180
REMARK 465 GLU z 181
REMARK 465 ILE z 182
REMARK 465 ASN z 183
REMARK 465 GLY z 184
REMARK 465 CYS z 185
REMARK 465 ILE z 186
REMARK 465 SER z 187
REMARK 465 THR z 188
REMARK 465 GLY z 189
REMARK 465 LYS z 190
REMARK 465 GLU z 191
REMARK 465 ALA z 192
REMARK 465 ASN z 193
REMARK 465 VAL z 194
REMARK 465 TYR z 195
REMARK 465 HIS z 196
REMARK 465 ALA z 197
REMARK 465 SER z 198
REMARK 465 THR z 199
REMARK 465 ALA z 200
REMARK 465 ASN z 201
REMARK 465 GLY z 202
REMARK 465 GLU z 203
REMARK 465 SER z 204
REMARK 465 ARG z 205
REMARK 465 ALA z 206
REMARK 465 ILE z 207
REMARK 465 LYS z 208
REMARK 465 ILE z 209
REMARK 465 TYR z 210
REMARK 465 LYS z 211
REMARK 465 THR z 212
REMARK 465 SER z 213
REMARK 465 ILE z 214
REMARK 465 LEU z 215
REMARK 465 VAL z 216
REMARK 465 PHE z 217
REMARK 465 LYS z 218
REMARK 465 ASP z 219
REMARK 465 ARG z 220
REMARK 465 ASP z 221
REMARK 465 LYS z 222
REMARK 465 TYR z 223
REMARK 465 VAL z 224
REMARK 465 SER z 225
REMARK 465 GLY z 226
REMARK 465 GLU z 227
REMARK 465 PHE z 228
REMARK 465 ARG z 229
REMARK 465 PHE z 230
REMARK 465 ARG z 231
REMARK 465 HIS z 232
REMARK 465 GLY z 233
REMARK 465 TYR z 234
REMARK 465 CYS z 235
REMARK 465 LYS z 236
REMARK 465 GLY z 237
REMARK 465 ASN z 238
REMARK 465 PRO z 239
REMARK 465 ARG z 240
REMARK 465 LYS z 241
REMARK 465 MET z 242
REMARK 465 VAL z 243
REMARK 465 LYS z 244
REMARK 465 THR z 245
REMARK 465 TRP z 246
REMARK 465 ALA z 247
REMARK 465 GLU z 248
REMARK 465 LYS z 249
REMARK 465 GLU z 250
REMARK 465 MET z 251
REMARK 465 ARG z 252
REMARK 465 ASN z 253
REMARK 465 LEU z 254
REMARK 465 ILE z 255
REMARK 465 ARG z 256
REMARK 465 LEU z 257
REMARK 465 ASN z 258
REMARK 465 THR z 259
REMARK 465 ALA z 260
REMARK 465 GLU z 261
REMARK 465 ILE z 262
REMARK 465 PRO z 263
REMARK 465 CYS z 264
REMARK 465 PRO z 265
REMARK 465 GLU z 266
REMARK 465 PRO z 267
REMARK 465 ILE z 268
REMARK 465 MET z 269
REMARK 465 LEU z 270
REMARK 465 ARG z 271
REMARK 465 SER z 272
REMARK 465 HIS z 273
REMARK 465 VAL z 274
REMARK 465 LEU z 275
REMARK 465 VAL z 276
REMARK 465 MET z 277
REMARK 465 SER z 278
REMARK 465 PHE z 279
REMARK 465 ILE z 280
REMARK 465 GLY z 281
REMARK 465 LYS z 282
REMARK 465 ASP z 283
REMARK 465 ASP z 284
REMARK 465 MET z 285
REMARK 465 PRO z 286
REMARK 465 ALA z 287
REMARK 465 PRO z 288
REMARK 465 LEU z 289
REMARK 465 LEU z 290
REMARK 465 LYS z 291
REMARK 465 ASN z 292
REMARK 465 VAL z 293
REMARK 465 GLN z 294
REMARK 465 LEU z 295
REMARK 465 SER z 296
REMARK 465 GLU z 297
REMARK 465 SER z 298
REMARK 465 LYS z 299
REMARK 465 ALA z 300
REMARK 465 ARG z 301
REMARK 465 GLU z 302
REMARK 465 LEU z 303
REMARK 465 TYR z 304
REMARK 465 LEU z 305
REMARK 465 GLN z 306
REMARK 465 VAL z 307
REMARK 465 ILE z 308
REMARK 465 GLN z 309
REMARK 465 TYR z 310
REMARK 465 MET z 311
REMARK 465 ARG z 312
REMARK 465 ARG z 313
REMARK 465 MET z 314
REMARK 465 TYR z 315
REMARK 465 GLN z 316
REMARK 465 ASP z 317
REMARK 465 ALA z 318
REMARK 465 ARG z 319
REMARK 465 LEU z 320
REMARK 465 VAL z 321
REMARK 465 HIS z 322
REMARK 465 ALA z 323
REMARK 465 ASP z 324
REMARK 465 LEU z 325
REMARK 465 SER z 326
REMARK 465 GLU z 327
REMARK 465 PHE z 328
REMARK 465 ASN z 329
REMARK 465 MET z 330
REMARK 465 LEU z 331
REMARK 465 TYR z 332
REMARK 465 HIS z 333
REMARK 465 GLY z 334
REMARK 465 GLY z 335
REMARK 465 GLY z 336
REMARK 465 VAL z 337
REMARK 465 TYR z 338
REMARK 465 ILE z 339
REMARK 465 ILE z 340
REMARK 465 ASP z 341
REMARK 465 VAL z 342
REMARK 465 SER z 343
REMARK 465 GLN z 344
REMARK 465 SER z 345
REMARK 465 VAL z 346
REMARK 465 GLU z 347
REMARK 465 HIS z 348
REMARK 465 ASP z 349
REMARK 465 HIS z 350
REMARK 465 PRO z 351
REMARK 465 HIS z 352
REMARK 465 ALA z 353
REMARK 465 LEU z 354
REMARK 465 GLU z 355
REMARK 465 PHE z 356
REMARK 465 LEU z 357
REMARK 465 ARG z 358
REMARK 465 LYS z 359
REMARK 465 ASP z 360
REMARK 465 CYS z 361
REMARK 465 ALA z 362
REMARK 465 ASN z 363
REMARK 465 VAL z 364
REMARK 465 ASN z 365
REMARK 465 ASP z 366
REMARK 465 PHE z 367
REMARK 465 PHE z 368
REMARK 465 MET z 369
REMARK 465 ARG z 370
REMARK 465 HIS z 371
REMARK 465 SER z 372
REMARK 465 VAL z 373
REMARK 465 ALA z 374
REMARK 465 VAL z 375
REMARK 465 MET z 376
REMARK 465 THR z 377
REMARK 465 VAL z 378
REMARK 465 ARG z 379
REMARK 465 GLU z 380
REMARK 465 LEU z 381
REMARK 465 PHE z 382
REMARK 465 GLU z 383
REMARK 465 PHE z 384
REMARK 465 VAL z 385
REMARK 465 THR z 386
REMARK 465 ASP z 387
REMARK 465 PRO z 388
REMARK 465 SER z 389
REMARK 465 ILE z 390
REMARK 465 THR z 391
REMARK 465 HIS z 392
REMARK 465 GLU z 393
REMARK 465 ASN z 394
REMARK 465 MET z 395
REMARK 465 ASP z 396
REMARK 465 ALA z 397
REMARK 465 TYR z 398
REMARK 465 LEU z 399
REMARK 465 SER z 400
REMARK 465 LYS z 401
REMARK 465 ALA z 402
REMARK 465 MET z 403
REMARK 465 GLU z 404
REMARK 465 ILE z 405
REMARK 465 ALA z 406
REMARK 465 SER z 407
REMARK 465 GLN z 408
REMARK 465 ARG z 409
REMARK 465 THR z 410
REMARK 465 LYS z 411
REMARK 465 GLU z 412
REMARK 465 GLU z 413
REMARK 465 ARG z 414
REMARK 465 SER z 415
REMARK 465 SER z 416
REMARK 465 GLN z 417
REMARK 465 ASP z 418
REMARK 465 HIS z 419
REMARK 465 VAL z 420
REMARK 465 ASP z 421
REMARK 465 GLU z 422
REMARK 465 GLU z 423
REMARK 465 VAL z 424
REMARK 465 PHE z 425
REMARK 465 LYS z 426
REMARK 465 ARG z 427
REMARK 465 ALA z 428
REMARK 465 TYR z 429
REMARK 465 ILE z 430
REMARK 465 PRO z 431
REMARK 465 ARG z 432
REMARK 465 THR z 433
REMARK 465 LEU z 434
REMARK 465 ASN z 435
REMARK 465 GLU z 436
REMARK 465 VAL z 437
REMARK 465 LYS z 438
REMARK 465 ASN z 439
REMARK 465 TYR z 440
REMARK 465 GLU z 441
REMARK 465 ARG z 442
REMARK 465 ASP z 443
REMARK 465 MET z 444
REMARK 465 ASP z 445
REMARK 465 ILE z 446
REMARK 465 ILE z 447
REMARK 465 MET z 448
REMARK 465 LYS z 449
REMARK 465 LEU z 450
REMARK 465 LYS z 451
REMARK 465 GLU z 452
REMARK 465 GLU z 453
REMARK 465 ASP z 454
REMARK 465 MET z 455
REMARK 465 ALA z 456
REMARK 465 MET z 457
REMARK 465 ASN z 458
REMARK 465 ALA z 459
REMARK 465 GLN z 460
REMARK 465 GLN z 461
REMARK 465 ASP z 462
REMARK 465 ASN z 463
REMARK 465 ILE z 464
REMARK 465 LEU z 465
REMARK 465 TYR z 466
REMARK 465 GLN z 467
REMARK 465 THR z 468
REMARK 465 VAL z 469
REMARK 465 THR z 470
REMARK 465 GLY z 471
REMARK 465 LEU z 472
REMARK 465 LYS z 473
REMARK 465 LYS z 474
REMARK 465 ASP z 475
REMARK 465 LEU z 476
REMARK 465 SER z 477
REMARK 465 GLY z 478
REMARK 465 VAL z 479
REMARK 465 GLN z 480
REMARK 465 LYS z 481
REMARK 465 VAL z 482
REMARK 465 PRO z 483
REMARK 465 ALA z 484
REMARK 465 LEU z 485
REMARK 465 LEU z 486
REMARK 465 GLU z 487
REMARK 465 ASN z 488
REMARK 465 GLN z 489
REMARK 465 VAL z 490
REMARK 465 GLU z 491
REMARK 465 GLU z 492
REMARK 465 ARG z 493
REMARK 465 THR z 494
REMARK 465 CYS z 495
REMARK 465 SER z 496
REMARK 465 ASP z 497
REMARK 465 SER z 498
REMARK 465 GLU z 499
REMARK 465 ASP z 500
REMARK 465 ILE z 501
REMARK 465 GLY z 502
REMARK 465 SER z 503
REMARK 465 SER z 504
REMARK 465 GLU z 505
REMARK 465 CYS z 506
REMARK 465 SER z 507
REMARK 465 ASP z 508
REMARK 465 THR z 509
REMARK 465 ASP z 510
REMARK 465 SER z 511
REMARK 465 GLU z 512
REMARK 465 GLU z 513
REMARK 465 GLN z 514
REMARK 465 GLY z 515
REMARK 465 ASP z 516
REMARK 465 HIS z 517
REMARK 465 ALA z 518
REMARK 465 ARG z 519
REMARK 465 PRO z 520
REMARK 465 LYS z 521
REMARK 465 LYS z 522
REMARK 465 HIS z 523
REMARK 465 THR z 524
REMARK 465 THR z 525
REMARK 465 ASP z 526
REMARK 465 PRO z 527
REMARK 465 ASP z 528
REMARK 465 ILE z 529
REMARK 465 ASP z 530
REMARK 465 LYS z 560
REMARK 465 THR z 561
REMARK 465 ALA z 562
REMARK 465 LYS z 563
REMARK 465 THR z 564
REMARK 465 LYS z 565
REMARK 465 LYS z 566
REMARK 465 GLY z 567
REMARK 465 LYS z 568
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 THR R 55 OG1 CG2
REMARK 470 GLU x 73 CG CD OE1 OE2
REMARK 470 GLU x 161 CG CD OE1 OE2
REMARK 470 GLU x 164 CG CD OE1 OE2
REMARK 470 ASP x 167 CG OD1 OD2
REMARK 470 ASP x 174 CG OD1 OD2
REMARK 470 ARG y 396 CG CD NE CZ NH1 NH2
REMARK 470 ASN y 402 CG OD1 ND2
REMARK 470 ARG y 412 CG CD NE CZ NH1 NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 OP1 U 2 1867 N GLY y 393 1.82
REMARK 500 CG1 VAL R 66 CG1 ILE R 69 1.86
REMARK 500 O2' A 2 1869 NE2 HIS y 118 1.95
REMARK 500 NZ LYS y 72 OE2 GLU y 106 2.04
REMARK 500 N2 G 2 1606 N7 A 2 1633 2.13
REMARK 500 O6 G 2 1722 O2 U 2 1812 2.17
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 A 2 560 N9 A 2 560 C4 -0.037
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 C 2 14 C6 - N1 - C2 ANGL. DEV. = -2.5 DEGREES
REMARK 500 U 2 15 C5 - C6 - N1 ANGL. DEV. = 3.0 DEGREES
REMARK 500 U 2 34 N3 - C2 - O2 ANGL. DEV. = -4.7 DEGREES
REMARK 500 C 2 37 C6 - N1 - C2 ANGL. DEV. = -2.9 DEGREES
REMARK 500 U 2 97 C5 - C6 - N1 ANGL. DEV. = 3.1 DEGREES
REMARK 500 G 2 130 N3 - C4 - C5 ANGL. DEV. = -3.3 DEGREES
REMARK 500 G 2 130 N3 - C4 - N9 ANGL. DEV. = 3.7 DEGREES
REMARK 500 G 2 130 C4 - N9 - C1' ANGL. DEV. = 9.5 DEGREES
REMARK 500 C 2 178 C5 - C6 - N1 ANGL. DEV. = 3.0 DEGREES
REMARK 500 C 2 178 N1 - C2 - O2 ANGL. DEV. = 4.8 DEGREES
REMARK 500 C 2 178 C2 - N1 - C1' ANGL. DEV. = 7.9 DEGREES
REMARK 500 C 2 199 N1 - C2 - O2 ANGL. DEV. = 4.2 DEGREES
REMARK 500 C 2 293 N1 - C2 - O2 ANGL. DEV. = 4.8 DEGREES
REMARK 500 C 2 293 C2 - N1 - C1' ANGL. DEV. = 8.6 DEGREES
REMARK 500 C 2 315 C6 - N1 - C2 ANGL. DEV. = -2.8 DEGREES
REMARK 500 C 2 315 C2 - N1 - C1' ANGL. DEV. = 6.6 DEGREES
REMARK 500 C 2 321 N1 - C2 - O2 ANGL. DEV. = 4.2 DEGREES
REMARK 500 C 2 321 C2 - N1 - C1' ANGL. DEV. = 7.1 DEGREES
REMARK 500 C 2 331 N1 - C2 - O2 ANGL. DEV. = 4.0 DEGREES
REMARK 500 C 2 341 C6 - N1 - C2 ANGL. DEV. = -2.5 DEGREES
REMARK 500 C 2 341 C5 - C6 - N1 ANGL. DEV. = 4.1 DEGREES
REMARK 500 C 2 341 N1 - C2 - O2 ANGL. DEV. = 3.9 DEGREES
REMARK 500 C 2 341 C6 - N1 - C1' ANGL. DEV. = -7.5 DEGREES
REMARK 500 C 2 341 C2 - N1 - C1' ANGL. DEV. = 9.9 DEGREES
REMARK 500 C 2 350 N1 - C2 - O2 ANGL. DEV. = 3.8 DEGREES
REMARK 500 C 2 353 C5 - C6 - N1 ANGL. DEV. = 3.1 DEGREES
REMARK 500 C 2 356 N1 - C2 - O2 ANGL. DEV. = 8.4 DEGREES
REMARK 500 C 2 356 N3 - C2 - O2 ANGL. DEV. = -8.1 DEGREES
REMARK 500 C 2 356 C6 - N1 - C1' ANGL. DEV. = -10.2 DEGREES
REMARK 500 C 2 356 C2 - N1 - C1' ANGL. DEV. = 12.4 DEGREES
REMARK 500 C 2 369 N1 - C2 - O2 ANGL. DEV. = 3.9 DEGREES
REMARK 500 U 2 378 C5 - C6 - N1 ANGL. DEV. = 3.1 DEGREES
REMARK 500 C 2 409 C5 - C6 - N1 ANGL. DEV. = 3.6 DEGREES
REMARK 500 C 2 417 N1 - C2 - O2 ANGL. DEV. = 4.8 DEGREES
REMARK 500 C 2 441 C5 - C6 - N1 ANGL. DEV. = 3.1 DEGREES
REMARK 500 C 2 441 C2 - N1 - C1' ANGL. DEV. = 6.9 DEGREES
REMARK 500 C 2 442 C6 - N1 - C2 ANGL. DEV. = -3.6 DEGREES
REMARK 500 C 2 442 C5 - C6 - N1 ANGL. DEV. = 4.0 DEGREES
REMARK 500 C 2 442 C2 - N1 - C1' ANGL. DEV. = 8.8 DEGREES
REMARK 500 C 2 459 C6 - N1 - C2 ANGL. DEV. = -3.0 DEGREES
REMARK 500 C 2 459 C5 - C6 - N1 ANGL. DEV. = 3.8 DEGREES
REMARK 500 C 2 459 C2 - N1 - C1' ANGL. DEV. = 7.3 DEGREES
REMARK 500 C 2 463 C6 - N1 - C2 ANGL. DEV. = -3.0 DEGREES
REMARK 500 C 2 463 N3 - C2 - O2 ANGL. DEV. = -4.7 DEGREES
REMARK 500 C 2 483 N1 - C2 - O2 ANGL. DEV. = 3.7 DEGREES
REMARK 500 C 2 494 C6 - N1 - C2 ANGL. DEV. = -2.9 DEGREES
REMARK 500 C 2 494 C5 - C6 - N1 ANGL. DEV. = 3.6 DEGREES
REMARK 500 C 2 494 N1 - C2 - O2 ANGL. DEV. = 4.7 DEGREES
REMARK 500 C 2 494 N3 - C2 - O2 ANGL. DEV. = -4.3 DEGREES
REMARK 500 C 2 494 C2 - N1 - C1' ANGL. DEV. = 7.4 DEGREES
REMARK 500
REMARK 500 THIS ENTRY HAS 255 ANGLE DEVIATIONS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 PRO A 127 0.70 -69.55
REMARK 500 ASN A 165 16.84 -140.78
REMARK 500 THR A 188 -159.02 -81.20
REMARK 500 SER A 190 -167.96 -116.94
REMARK 500 ASP A 206 79.66 55.21
REMARK 500 PRO A 207 -1.79 -54.27
REMARK 500 GLN B 53 38.16 -98.66
REMARK 500 MET B 103 149.74 -171.02
REMARK 500 HIS B 124 112.14 -162.14
REMARK 500 ILE B 204 -63.76 -106.06
REMARK 500 ASN C 134 6.65 81.65
REMARK 500 SER C 161 26.27 -143.33
REMARK 500 HIS C 178 -31.17 -131.02
REMARK 500 LEU C 255 30.21 -96.14
REMARK 500 PHE C 269 36.70 -99.02
REMARK 500 ALA D 52 -167.66 -164.22
REMARK 500 CYS D 134 131.79 -172.67
REMARK 500 LYS D 148 -166.49 -127.58
REMARK 500 TRP D 192 -159.18 -80.90
REMARK 500 ASP D 193 90.17 65.98
REMARK 500 PRO D 194 152.59 -40.54
REMARK 500 LYS D 197 1.04 81.44
REMARK 500 ARG E 30 81.67 50.24
REMARK 500 THR E 133 73.50 60.78
REMARK 500 TYR E 149 70.78 62.31
REMARK 500 ASN E 157 5.70 80.73
REMARK 500 CYS E 181 -168.52 -161.93
REMARK 500 ASP E 212 -168.79 -73.70
REMARK 500 PHE E 218 -169.99 -164.27
REMARK 500 PHE E 226 109.08 -162.11
REMARK 500 ILE E 228 -57.18 -128.82
REMARK 500 SER E 237 -168.64 -78.04
REMARK 500 PRO E 239 -176.15 -68.08
REMARK 500 ALA F 40 -156.84 -79.19
REMARK 500 VAL F 41 122.48 -32.95
REMARK 500 LYS F 42 -39.49 -130.51
REMARK 500 GLU F 43 -55.14 -121.78
REMARK 500 ASN F 165 -178.30 -175.86
REMARK 500 LYS G 14 138.32 -171.69
REMARK 500 ALA G 33 14.06 59.30
REMARK 500 ALA G 38 55.97 -97.33
REMARK 500 GLU G 44 30.66 -93.77
REMARK 500 ASP G 103 -169.07 -126.05
REMARK 500 PRO G 130 -169.57 -78.63
REMARK 500 LYS H 37 -60.76 -101.42
REMARK 500 ARG H 120 61.36 -101.45
REMARK 500 ARG I 5 37.02 -94.83
REMARK 500 GLU I 28 32.61 -92.13
REMARK 500 CYS I 182 -30.80 -131.15
REMARK 500 ARG J 133 62.23 62.97
REMARK 500
REMARK 500 THIS ENTRY HAS 154 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 ILE A 189 SER A 190 -136.20
REMARK 500 PRO D 194 THR D 195 -149.11
REMARK 500 ALA F 40 VAL F 41 -133.43
REMARK 500 ALA F 138 VAL F 139 147.81
REMARK 500 GLY L 41 LEU L 42 -149.97
REMARK 500 PRO S 80 ASP S 81 -134.12
REMARK 500 LYS X 60 GLN X 61 -146.20
REMARK 500 ASN X 127 VAL X 128 145.24
REMARK 500 HIS Y 29 PRO Y 30 -149.56
REMARK 500 MET c 35 ASP c 36 148.19
REMARK 500 ILE g 31 LEU g 32 -147.52
REMARK 500 TRP g 259 ASP g 260 148.21
REMARK 500 SER x 113 ARG x 114 -144.19
REMARK 500 SER x 162 PHE x 163 -138.67
REMARK 500 GLU y 106 PRO y 107 -149.59
REMARK 500 THR y 210 PRO y 211 -145.82
REMARK 500 ASP y 365 TYR y 366 -147.17
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN d 201 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS d 21 SG
REMARK 620 2 CYS d 24 SG 112.4
REMARK 620 3 CYS d 39 SG 102.3 120.0
REMARK 620 4 CYS d 42 SG 134.6 92.3 96.4
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN f 201 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS f 121 SG
REMARK 620 2 CYS f 141 SG 127.2
REMARK 620 3 CYS f 144 SG 110.5 113.5
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN y 500 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS y 270 SG
REMARK 620 2 CYS y 273 SG 89.4
REMARK 620 3 CYS y 285 SG 76.9 154.8
REMARK 620 4 CYS y 288 SG 143.3 92.2 86.7
REMARK 620 N 1 2 3
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN d 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN f 201
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN y 500
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-4353 RELATED DB: EMDB
REMARK 900 CRYO-EM STRUCTURE OF A LATE HUMAN PRE-40S RIBOSOMAL SUBUNIT - STATE
REMARK 900 R
DBREF1 6G5I 2 1 1882 GB AL353644.34
DBREF2 6G5I 2 151415227 125931 127812
DBREF 6G5I A 1 295 UNP P08865 RSSA_HUMAN 1 295
DBREF 6G5I B 1 264 UNP P61247 RS3A_HUMAN 1 264
DBREF 6G5I C 1 293 UNP P15880 RS2_HUMAN 1 293
DBREF 6G5I D 1 243 UNP P23396 RS3_HUMAN 1 243
DBREF 6G5I E 1 263 UNP P62701 RS4X_HUMAN 1 263
DBREF 6G5I F 1 204 UNP P46782 RS5_HUMAN 1 204
DBREF 6G5I G 1 249 UNP P62753 RS6_HUMAN 1 249
DBREF 6G5I H 1 194 UNP P62081 RS7_HUMAN 1 194
DBREF 6G5I I 1 208 UNP P62241 RS8_HUMAN 1 208
DBREF 6G5I J 1 194 UNP P46781 RS9_HUMAN 1 194
DBREF 6G5I K 1 165 UNP P46783 RS10_HUMAN 1 165
DBREF 6G5I L 1 158 UNP P62280 RS11_HUMAN 1 158
DBREF 6G5I M 1 132 UNP P25398 RS12_HUMAN 1 132
DBREF 6G5I N 1 151 UNP P62277 RS13_HUMAN 1 151
DBREF 6G5I O 1 151 UNP P62263 RS14_HUMAN 1 151
DBREF 6G5I P 1 145 UNP P62841 RS15_HUMAN 1 145
DBREF 6G5I Q 1 146 UNP P62249 RS16_HUMAN 1 146
DBREF 6G5I R 1 135 UNP P08708 RS17_HUMAN 1 135
DBREF 6G5I S 1 152 UNP P62269 RS18_HUMAN 1 152
DBREF 6G5I T 1 145 UNP P39019 RS19_HUMAN 1 145
DBREF 6G5I U 1 119 UNP P60866 RS20_HUMAN 1 119
DBREF 6G5I V 1 83 UNP P63220 RS21_HUMAN 1 83
DBREF 6G5I W 1 130 UNP P62244 RS15A_HUMAN 1 130
DBREF 6G5I X 1 143 UNP P62266 RS23_HUMAN 1 143
DBREF 6G5I Y 1 133 UNP P62847 RS24_HUMAN 1 133
DBREF 6G5I Z 1 125 UNP P62851 RS25_HUMAN 1 125
DBREF 6G5I b 1 84 UNP P42677 RS27_HUMAN 1 84
DBREF 6G5I c 1 69 UNP P62857 RS28_HUMAN 1 69
DBREF 6G5I d 1 56 UNP P62273 RS29_HUMAN 1 56
DBREF 6G5I e 1 59 UNP P62861 RS30_HUMAN 1 59
DBREF 6G5I f 1 156 UNP Q5RKT7 Q5RKT7_HUMAN 1 156
DBREF 6G5I g 1 317 UNP P63244 RACK1_HUMAN 1 317
DBREF 6G5I x 1 252 UNP Q9NRX1 PNO1_HUMAN 1 252
DBREF 6G5I y 1 412 UNP Q9ULX3 NOB1_HUMAN 1 412
DBREF 6G5I z 1 568 UNP Q9BRS2 RIOK1_HUMAN 1 568
SEQRES 1 2 1882 U A C C U G G U U G A U C
SEQRES 2 2 1882 C U G C C A G U A G C A U
SEQRES 3 2 1882 A U G C U U G U C U C A A
SEQRES 4 2 1882 A G A U U A A G C C A U G
SEQRES 5 2 1882 C A U G U C U A A G U A C
SEQRES 6 2 1882 G C A C G G C C G G U A C
SEQRES 7 2 1882 A G U G A A A C U G C G A
SEQRES 8 2 1882 A U G G C U C A U U A A A
SEQRES 9 2 1882 U C A G U U A U G G U U C
SEQRES 10 2 1882 C U U U G G U C G C U C G
SEQRES 11 2 1882 C U C C U C U C C U A C U
SEQRES 12 2 1882 U G G A U A A C U G U G G
SEQRES 13 2 1882 U A A U U C U A G A G C U
SEQRES 14 2 1882 A A U A C A U G C C G A C
SEQRES 15 2 1882 G G G C G C U G A C C C C
SEQRES 16 2 1882 C U U C G C G G G G G G G
SEQRES 17 2 1882 A U G C G U G C A U U U A
SEQRES 18 2 1882 U C A G A U C A A A A C C
SEQRES 19 2 1882 A A C C C G G U C A G C C
SEQRES 20 2 1882 C C U C U C C G G C C C C
SEQRES 21 2 1882 G G C C G G G G G G C G G
SEQRES 22 2 1882 G C G C C G G C G G C U U
SEQRES 23 2 1882 U G G U G A C U C U A G A
SEQRES 24 2 1882 U A A C C U C G G G C C G
SEQRES 25 2 1882 A U C G C A C G C C C C C
SEQRES 26 2 1882 C G U G G C G G C G A C G
SEQRES 27 2 1882 A C C C A U U C G A A C G
SEQRES 28 2 1882 U C U G C C C U A U C A A
SEQRES 29 2 1882 C U U U C G A U G G U A G
SEQRES 30 2 1882 U C G C C G U G C C U A C
SEQRES 31 2 1882 C A U G G U G A C C A C G
SEQRES 32 2 1882 G G U G A C G G G G A A U
SEQRES 33 2 1882 C A G G G U U C G A U U C
SEQRES 34 2 1882 C G G A G A G G G A G C C
SEQRES 35 2 1882 U G A G A A A C G G C U A
SEQRES 36 2 1882 C C A C A U C C A A G G A
SEQRES 37 2 1882 A G G C A G C A G G C G C
SEQRES 38 2 1882 G C A A A U U A C C C A C
SEQRES 39 2 1882 U C C C G A C C C G G G G
SEQRES 40 2 1882 A G G U A G U G A C G A A
SEQRES 41 2 1882 A A A U A A C A A U A C A
SEQRES 42 2 1882 G G A C U C U U U C G A G
SEQRES 43 2 1882 G C C C U G U A A U U G G
SEQRES 44 2 1882 A A U G A G U C C A C U U
SEQRES 45 2 1882 U A A A U C C U U U A A C
SEQRES 46 2 1882 G A G G A U C C A U U G G
SEQRES 47 2 1882 A G G G C A A G U C U G G
SEQRES 48 2 1882 U G C C A G C A G C C G C
SEQRES 49 2 1882 G G U A A U U C C A G C U
SEQRES 50 2 1882 C C A A U A G C G U A U A
SEQRES 51 2 1882 U U A A A G U U G C U G C
SEQRES 52 2 1882 A G U U A A A A A G C U C
SEQRES 53 2 1882 G U A G U U G G A U C U U
SEQRES 54 2 1882 G G G A G C G G G C G G G
SEQRES 55 2 1882 C G G U C C G C C G C G A
SEQRES 56 2 1882 G G C G A G C C A C C G C
SEQRES 57 2 1882 C C G U C C C C G C C C C
SEQRES 58 2 1882 U U G C C U C U C G G C G
SEQRES 59 2 1882 C C C C C U C G A U G C U
SEQRES 60 2 1882 C U U A G C U G A G U G U
SEQRES 61 2 1882 C C C G C G G G G C C C G
SEQRES 62 2 1882 A A G C G U U U A C U U U
SEQRES 63 2 1882 G A A A A A A U U A G A G
SEQRES 64 2 1882 U G U U C A A A G C A G G
SEQRES 65 2 1882 C C C G A G C C G C C U G
SEQRES 66 2 1882 G A U A C C G C A G C U A
SEQRES 67 2 1882 G G A A U A A U G G A A U
SEQRES 68 2 1882 A G G A C C G C G G U U C
SEQRES 69 2 1882 U A U U U U G U U G G U U
SEQRES 70 2 1882 U U C G G A A C U G A G G
SEQRES 71 2 1882 C C A U G A U U A A G A G
SEQRES 72 2 1882 G G A C G G C C G G G G G
SEQRES 73 2 1882 C A U U C G U A U U G C G
SEQRES 74 2 1882 C C G C U A G A G G U G A
SEQRES 75 2 1882 A A U U C U U G G A C C G
SEQRES 76 2 1882 G C G C A A G A C G G A C
SEQRES 77 2 1882 C A G A G C G A A A G C A
SEQRES 78 2 1882 U U U G C C A A G A A U G
SEQRES 79 2 1882 U U U U C A U U A A U C A
SEQRES 80 2 1882 A G A A C G A A A G U C G
SEQRES 81 2 1882 G A G G U U C G A A G A C
SEQRES 82 2 1882 G A U C A G A U A C C G U
SEQRES 83 2 1882 C G U A G U U C C G A C C
SEQRES 84 2 1882 A U A A A C G A U G C C G
SEQRES 85 2 1882 A C C G G C G A U G C G G
SEQRES 86 2 1882 C G G C G U U A U U C C C
SEQRES 87 2 1882 A U G A C C C G C C G G G
SEQRES 88 2 1882 C A G C U U C C G G G A A
SEQRES 89 2 1882 A C C A A A G U C U U U G
SEQRES 90 2 1882 G G U U C C G G G G G G A
SEQRES 91 2 1882 G U A U G G U U G C A A A
SEQRES 92 2 1882 G C U G A A A C U U A A A
SEQRES 93 2 1882 G G A A U U G A C G G A A
SEQRES 94 2 1882 G G G C A C C A C C A G G
SEQRES 95 2 1882 A G U G G A G C C U G C G
SEQRES 96 2 1882 G C U U A A U U U G A C U
SEQRES 97 2 1882 C A A C A C G G G A A A C
SEQRES 98 2 1882 C U C A C C C G G C C C G
SEQRES 99 2 1882 G A C A C G G A C A G G A
SEQRES 100 2 1882 U U G A C A G A U U G A U
SEQRES 101 2 1882 A G C U C U U U C U C G A
SEQRES 102 2 1882 U U C C G U G G G U G G U
SEQRES 103 2 1882 G G U G C A U G G C C G U
SEQRES 104 2 1882 U C U U A G U U G G U G G
SEQRES 105 2 1882 A G C G A U U U G U C U G
SEQRES 106 2 1882 G U U A A U U C C G A U A
SEQRES 107 2 1882 A C G A A C G A G A C U C
SEQRES 108 2 1882 U G G C A U G C U A A C U
SEQRES 109 2 1882 A G U U A C G C G A C C C
SEQRES 110 2 1882 C C G A G C G G U C G G C
SEQRES 111 2 1882 G U C C C C C A A C U U C
SEQRES 112 2 1882 U U A G A G G G A C A A G
SEQRES 113 2 1882 U G G C G U U C A G C C A
SEQRES 114 2 1882 C C C G A G A U U G A G C
SEQRES 115 2 1882 A A U A A C A G G U C U G
SEQRES 116 2 1882 U G A U G C C C U U A G A
SEQRES 117 2 1882 U G U C C G G G G C U G C
SEQRES 118 2 1882 A C G C G C G C U A C A C
SEQRES 119 2 1882 U G A C U G G C U C A G C
SEQRES 120 2 1882 G U G U G C C U A C C C U
SEQRES 121 2 1882 A C G C C G G C A G G C G
SEQRES 122 2 1882 C G G G U A A C C C G U U
SEQRES 123 2 1882 G A A C C C C A U U C G U
SEQRES 124 2 1882 G A U G G G G A U C G G G
SEQRES 125 2 1882 G A U U G C A A U U A U U
SEQRES 126 2 1882 C C C C A U G A A C G A G
SEQRES 127 2 1882 G A A U U C C C A G U A A
SEQRES 128 2 1882 G U G C G G G U C A U A A
SEQRES 129 2 1882 G C U U G C G U U G A U U
SEQRES 130 2 1882 A A G U C C C U G C C C U
SEQRES 131 2 1882 U U G U A C A C A C C G C
SEQRES 132 2 1882 C C G U C G C U A C U A C
SEQRES 133 2 1882 C G A U U G G A U G G U U
SEQRES 134 2 1882 U A G U G A G G C C C U C
SEQRES 135 2 1882 G G A U C G G C C C C G C
SEQRES 136 2 1882 C G G G G U C G G C C C A
SEQRES 137 2 1882 C G G C C C U G G C G G A
SEQRES 138 2 1882 G C G C U G A G A A G A C
SEQRES 139 2 1882 G G U C G A A C U U G A C
SEQRES 140 2 1882 U A U C U A G A G G A A G
SEQRES 141 2 1882 U A A A A G U C G U A A C
SEQRES 142 2 1882 A A G G U U U C C G U A G
SEQRES 143 2 1882 G U G A A C C U G C G G A
SEQRES 144 2 1882 A G G A U C A U U A A C G
SEQRES 145 2 1882 G A G C C C G G A G
SEQRES 1 A 295 MET SER GLY ALA LEU ASP VAL LEU GLN MET LYS GLU GLU
SEQRES 2 A 295 ASP VAL LEU LYS PHE LEU ALA ALA GLY THR HIS LEU GLY
SEQRES 3 A 295 GLY THR ASN LEU ASP PHE GLN MET GLU GLN TYR ILE TYR
SEQRES 4 A 295 LYS ARG LYS SER ASP GLY ILE TYR ILE ILE ASN LEU LYS
SEQRES 5 A 295 ARG THR TRP GLU LYS LEU LEU LEU ALA ALA ARG ALA ILE
SEQRES 6 A 295 VAL ALA ILE GLU ASN PRO ALA ASP VAL SER VAL ILE SER
SEQRES 7 A 295 SER ARG ASN THR GLY GLN ARG ALA VAL LEU LYS PHE ALA
SEQRES 8 A 295 ALA ALA THR GLY ALA THR PRO ILE ALA GLY ARG PHE THR
SEQRES 9 A 295 PRO GLY THR PHE THR ASN GLN ILE GLN ALA ALA PHE ARG
SEQRES 10 A 295 GLU PRO ARG LEU LEU VAL VAL THR ASP PRO ARG ALA ASP
SEQRES 11 A 295 HIS GLN PRO LEU THR GLU ALA SER TYR VAL ASN LEU PRO
SEQRES 12 A 295 THR ILE ALA LEU CYS ASN THR ASP SER PRO LEU ARG TYR
SEQRES 13 A 295 VAL ASP ILE ALA ILE PRO CYS ASN ASN LYS GLY ALA HIS
SEQRES 14 A 295 SER VAL GLY LEU MET TRP TRP MET LEU ALA ARG GLU VAL
SEQRES 15 A 295 LEU ARG MET ARG GLY THR ILE SER ARG GLU HIS PRO TRP
SEQRES 16 A 295 GLU VAL MET PRO ASP LEU TYR PHE TYR ARG ASP PRO GLU
SEQRES 17 A 295 GLU ILE GLU LYS GLU GLU GLN ALA ALA ALA GLU LYS ALA
SEQRES 18 A 295 VAL THR LYS GLU GLU PHE GLN GLY GLU TRP THR ALA PRO
SEQRES 19 A 295 ALA PRO GLU PHE THR ALA THR GLN PRO GLU VAL ALA ASP
SEQRES 20 A 295 TRP SER GLU GLY VAL GLN VAL PRO SER VAL PRO ILE GLN
SEQRES 21 A 295 GLN PHE PRO THR GLU ASP TRP SER ALA GLN PRO ALA THR
SEQRES 22 A 295 GLU ASP TRP SER ALA ALA PRO THR ALA GLN ALA THR GLU
SEQRES 23 A 295 TRP VAL GLY ALA THR THR ASP TRP SER
SEQRES 1 B 264 MET ALA VAL GLY LYS ASN LYS ARG LEU THR LYS GLY GLY
SEQRES 2 B 264 LYS LYS GLY ALA LYS LYS LYS VAL VAL ASP PRO PHE SER
SEQRES 3 B 264 LYS LYS ASP TRP TYR ASP VAL LYS ALA PRO ALA MET PHE
SEQRES 4 B 264 ASN ILE ARG ASN ILE GLY LYS THR LEU VAL THR ARG THR
SEQRES 5 B 264 GLN GLY THR LYS ILE ALA SER ASP GLY LEU LYS GLY ARG
SEQRES 6 B 264 VAL PHE GLU VAL SER LEU ALA ASP LEU GLN ASN ASP GLU
SEQRES 7 B 264 VAL ALA PHE ARG LYS PHE LYS LEU ILE THR GLU ASP VAL
SEQRES 8 B 264 GLN GLY LYS ASN CYS LEU THR ASN PHE HIS GLY MET ASP
SEQRES 9 B 264 LEU THR ARG ASP LYS MET CYS SER MET VAL LYS LYS TRP
SEQRES 10 B 264 GLN THR MET ILE GLU ALA HIS VAL ASP VAL LYS THR THR
SEQRES 11 B 264 ASP GLY TYR LEU LEU ARG LEU PHE CYS VAL GLY PHE THR
SEQRES 12 B 264 LYS LYS ARG ASN ASN GLN ILE ARG LYS THR SER TYR ALA
SEQRES 13 B 264 GLN HIS GLN GLN VAL ARG GLN ILE ARG LYS LYS MET MET
SEQRES 14 B 264 GLU ILE MET THR ARG GLU VAL GLN THR ASN ASP LEU LYS
SEQRES 15 B 264 GLU VAL VAL ASN LYS LEU ILE PRO ASP SER ILE GLY LYS
SEQRES 16 B 264 ASP ILE GLU LYS ALA CYS GLN SER ILE TYR PRO LEU HIS
SEQRES 17 B 264 ASP VAL PHE VAL ARG LYS VAL LYS MET LEU LYS LYS PRO
SEQRES 18 B 264 LYS PHE GLU LEU GLY LYS LEU MET GLU LEU HIS GLY GLU
SEQRES 19 B 264 GLY SER SER SER GLY LYS ALA THR GLY ASP GLU THR GLY
SEQRES 20 B 264 ALA LYS VAL GLU ARG ALA ASP GLY TYR GLU PRO PRO VAL
SEQRES 21 B 264 GLN GLU SER VAL
SEQRES 1 C 293 MET ALA ASP ASP ALA GLY ALA ALA GLY GLY PRO GLY GLY
SEQRES 2 C 293 PRO GLY GLY PRO GLY MET GLY ASN ARG GLY GLY PHE ARG
SEQRES 3 C 293 GLY GLY PHE GLY SER GLY ILE ARG GLY ARG GLY ARG GLY
SEQRES 4 C 293 ARG GLY ARG GLY ARG GLY ARG GLY ARG GLY ALA ARG GLY
SEQRES 5 C 293 GLY LYS ALA GLU ASP LYS GLU TRP MET PRO VAL THR LYS
SEQRES 6 C 293 LEU GLY ARG LEU VAL LYS ASP MET LYS ILE LYS SER LEU
SEQRES 7 C 293 GLU GLU ILE TYR LEU PHE SER LEU PRO ILE LYS GLU SER
SEQRES 8 C 293 GLU ILE ILE ASP PHE PHE LEU GLY ALA SER LEU LYS ASP
SEQRES 9 C 293 GLU VAL LEU LYS ILE MET PRO VAL GLN LYS GLN THR ARG
SEQRES 10 C 293 ALA GLY GLN ARG THR ARG PHE LYS ALA PHE VAL ALA ILE
SEQRES 11 C 293 GLY ASP TYR ASN GLY HIS VAL GLY LEU GLY VAL LYS CYS
SEQRES 12 C 293 SER LYS GLU VAL ALA THR ALA ILE ARG GLY ALA ILE ILE
SEQRES 13 C 293 LEU ALA LYS LEU SER ILE VAL PRO VAL ARG ARG GLY TYR
SEQRES 14 C 293 TRP GLY ASN LYS ILE GLY LYS PRO HIS THR VAL PRO CYS
SEQRES 15 C 293 LYS VAL THR GLY ARG CYS GLY SER VAL LEU VAL ARG LEU
SEQRES 16 C 293 ILE PRO ALA PRO ARG GLY THR GLY ILE VAL SER ALA PRO
SEQRES 17 C 293 VAL PRO LYS LYS LEU LEU MET MET ALA GLY ILE ASP ASP
SEQRES 18 C 293 CYS TYR THR SER ALA ARG GLY CYS THR ALA THR LEU GLY
SEQRES 19 C 293 ASN PHE ALA LYS ALA THR PHE ASP ALA ILE SER LYS THR
SEQRES 20 C 293 TYR SER TYR LEU THR PRO ASP LEU TRP LYS GLU THR VAL
SEQRES 21 C 293 PHE THR LYS SER PRO TYR GLN GLU PHE THR ASP HIS LEU
SEQRES 22 C 293 VAL LYS THR HIS THR ARG VAL SER VAL GLN ARG THR GLN
SEQRES 23 C 293 ALA PRO ALA VAL ALA THR THR
SEQRES 1 D 243 MET ALA VAL GLN ILE SER LYS LYS ARG LYS PHE VAL ALA
SEQRES 2 D 243 ASP GLY ILE PHE LYS ALA GLU LEU ASN GLU PHE LEU THR
SEQRES 3 D 243 ARG GLU LEU ALA GLU ASP GLY TYR SER GLY VAL GLU VAL
SEQRES 4 D 243 ARG VAL THR PRO THR ARG THR GLU ILE ILE ILE LEU ALA
SEQRES 5 D 243 THR ARG THR GLN ASN VAL LEU GLY GLU LYS GLY ARG ARG
SEQRES 6 D 243 ILE ARG GLU LEU THR ALA VAL VAL GLN LYS ARG PHE GLY
SEQRES 7 D 243 PHE PRO GLU GLY SER VAL GLU LEU TYR ALA GLU LYS VAL
SEQRES 8 D 243 ALA THR ARG GLY LEU CYS ALA ILE ALA GLN ALA GLU SER
SEQRES 9 D 243 LEU ARG TYR LYS LEU LEU GLY GLY LEU ALA VAL ARG ARG
SEQRES 10 D 243 ALA CYS TYR GLY VAL LEU ARG PHE ILE MET GLU SER GLY
SEQRES 11 D 243 ALA LYS GLY CYS GLU VAL VAL VAL SER GLY LYS LEU ARG
SEQRES 12 D 243 GLY GLN ARG ALA LYS SER MET LYS PHE VAL ASP GLY LEU
SEQRES 13 D 243 MET ILE HIS SER GLY ASP PRO VAL ASN TYR TYR VAL ASP
SEQRES 14 D 243 THR ALA VAL ARG HIS VAL LEU LEU ARG GLN GLY VAL LEU
SEQRES 15 D 243 GLY ILE LYS VAL LYS ILE MET LEU PRO TRP ASP PRO THR
SEQRES 16 D 243 GLY LYS ILE GLY PRO LYS LYS PRO LEU PRO ASP HIS VAL
SEQRES 17 D 243 SER ILE VAL GLU PRO LYS ASP GLU ILE LEU PRO THR THR
SEQRES 18 D 243 PRO ILE SER GLU GLN LYS GLY GLY LYS PRO GLU PRO PRO
SEQRES 19 D 243 ALA MET PRO GLN PRO VAL PRO THR ALA
SEQRES 1 E 263 MET ALA ARG GLY PRO LYS LYS HIS LEU LYS ARG VAL ALA
SEQRES 2 E 263 ALA PRO LYS HIS TRP MET LEU ASP LYS LEU THR GLY VAL
SEQRES 3 E 263 PHE ALA PRO ARG PRO SER THR GLY PRO HIS LYS LEU ARG
SEQRES 4 E 263 GLU CYS LEU PRO LEU ILE ILE PHE LEU ARG ASN ARG LEU
SEQRES 5 E 263 LYS TYR ALA LEU THR GLY ASP GLU VAL LYS LYS ILE CYS
SEQRES 6 E 263 MET GLN ARG PHE ILE LYS ILE ASP GLY LYS VAL ARG THR
SEQRES 7 E 263 ASP ILE THR TYR PRO ALA GLY PHE MET ASP VAL ILE SER
SEQRES 8 E 263 ILE ASP LYS THR GLY GLU ASN PHE ARG LEU ILE TYR ASP
SEQRES 9 E 263 THR LYS GLY ARG PHE ALA VAL HIS ARG ILE THR PRO GLU
SEQRES 10 E 263 GLU ALA LYS TYR LYS LEU CYS LYS VAL ARG LYS ILE PHE
SEQRES 11 E 263 VAL GLY THR LYS GLY ILE PRO HIS LEU VAL THR HIS ASP
SEQRES 12 E 263 ALA ARG THR ILE ARG TYR PRO ASP PRO LEU ILE LYS VAL
SEQRES 13 E 263 ASN ASP THR ILE GLN ILE ASP LEU GLU THR GLY LYS ILE
SEQRES 14 E 263 THR ASP PHE ILE LYS PHE ASP THR GLY ASN LEU CYS MET
SEQRES 15 E 263 VAL THR GLY GLY ALA ASN LEU GLY ARG ILE GLY VAL ILE
SEQRES 16 E 263 THR ASN ARG GLU ARG HIS PRO GLY SER PHE ASP VAL VAL
SEQRES 17 E 263 HIS VAL LYS ASP ALA ASN GLY ASN SER PHE ALA THR ARG
SEQRES 18 E 263 LEU SER ASN ILE PHE VAL ILE GLY LYS GLY ASN LYS PRO
SEQRES 19 E 263 TRP ILE SER LEU PRO ARG GLY LYS GLY ILE ARG LEU THR
SEQRES 20 E 263 ILE ALA GLU GLU ARG ASP LYS ARG LEU ALA ALA LYS GLN
SEQRES 21 E 263 SER SER GLY
SEQRES 1 F 204 MET THR GLU TRP GLU THR ALA ALA PRO ALA VAL ALA GLU
SEQRES 2 F 204 THR PRO ASP ILE LYS LEU PHE GLY LYS TRP SER THR ASP
SEQRES 3 F 204 ASP VAL GLN ILE ASN ASP ILE SER LEU GLN ASP TYR ILE
SEQRES 4 F 204 ALA VAL LYS GLU LYS TYR ALA LYS TYR LEU PRO HIS SER
SEQRES 5 F 204 ALA GLY ARG TYR ALA ALA LYS ARG PHE ARG LYS ALA GLN
SEQRES 6 F 204 CYS PRO ILE VAL GLU ARG LEU THR ASN SER MET MET MET
SEQRES 7 F 204 HIS GLY ARG ASN ASN GLY LYS LYS LEU MET THR VAL ARG
SEQRES 8 F 204 ILE VAL LYS HIS ALA PHE GLU ILE ILE HIS LEU LEU THR
SEQRES 9 F 204 GLY GLU ASN PRO LEU GLN VAL LEU VAL ASN ALA ILE ILE
SEQRES 10 F 204 ASN SER GLY PRO ARG GLU ASP SER THR ARG ILE GLY ARG
SEQRES 11 F 204 ALA GLY THR VAL ARG ARG GLN ALA VAL ASP VAL SER PRO
SEQRES 12 F 204 LEU ARG ARG VAL ASN GLN ALA ILE TRP LEU LEU CYS THR
SEQRES 13 F 204 GLY ALA ARG GLU ALA ALA PHE ARG ASN ILE LYS THR ILE
SEQRES 14 F 204 ALA GLU CYS LEU ALA ASP GLU LEU ILE ASN ALA ALA LYS
SEQRES 15 F 204 GLY SER SER ASN SER TYR ALA ILE LYS LYS LYS ASP GLU
SEQRES 16 F 204 LEU GLU ARG VAL ALA LYS SER ASN ARG
SEQRES 1 G 249 MET LYS LEU ASN ILE SER PHE PRO ALA THR GLY CYS GLN
SEQRES 2 G 249 LYS LEU ILE GLU VAL ASP ASP GLU ARG LYS LEU ARG THR
SEQRES 3 G 249 PHE TYR GLU LYS ARG MET ALA THR GLU VAL ALA ALA ASP
SEQRES 4 G 249 ALA LEU GLY GLU GLU TRP LYS GLY TYR VAL VAL ARG ILE
SEQRES 5 G 249 SER GLY GLY ASN ASP LYS GLN GLY PHE PRO MET LYS GLN
SEQRES 6 G 249 GLY VAL LEU THR HIS GLY ARG VAL ARG LEU LEU LEU SER
SEQRES 7 G 249 LYS GLY HIS SER CYS TYR ARG PRO ARG ARG THR GLY GLU
SEQRES 8 G 249 ARG LYS ARG LYS SER VAL ARG GLY CYS ILE VAL ASP ALA
SEQRES 9 G 249 ASN LEU SER VAL LEU ASN LEU VAL ILE VAL LYS LYS GLY
SEQRES 10 G 249 GLU LYS ASP ILE PRO GLY LEU THR ASP THR THR VAL PRO
SEQRES 11 G 249 ARG ARG LEU GLY PRO LYS ARG ALA SER ARG ILE ARG LYS
SEQRES 12 G 249 LEU PHE ASN LEU SER LYS GLU ASP ASP VAL ARG GLN TYR
SEQRES 13 G 249 VAL VAL ARG LYS PRO LEU ASN LYS GLU GLY LYS LYS PRO
SEQRES 14 G 249 ARG THR LYS ALA PRO LYS ILE GLN ARG LEU VAL THR PRO
SEQRES 15 G 249 ARG VAL LEU GLN HIS LYS ARG ARG ARG ILE ALA LEU LYS
SEQRES 16 G 249 LYS GLN ARG THR LYS LYS ASN LYS GLU GLU ALA ALA GLU
SEQRES 17 G 249 TYR ALA LYS LEU LEU ALA LYS ARG MET LYS GLU ALA LYS
SEQRES 18 G 249 GLU LYS ARG GLN GLU GLN ILE ALA LYS ARG ARG ARG LEU
SEQRES 19 G 249 SER SER LEU ARG ALA SER THR SER LYS SER GLU SER SER
SEQRES 20 G 249 GLN LYS
SEQRES 1 H 194 MET PHE SER SER SER ALA LYS ILE VAL LYS PRO ASN GLY
SEQRES 2 H 194 GLU LYS PRO ASP GLU PHE GLU SER GLY ILE SER GLN ALA
SEQRES 3 H 194 LEU LEU GLU LEU GLU MET ASN SER ASP LEU LYS ALA GLN
SEQRES 4 H 194 LEU ARG GLU LEU ASN ILE THR ALA ALA LYS GLU ILE GLU
SEQRES 5 H 194 VAL GLY GLY GLY ARG LYS ALA ILE ILE ILE PHE VAL PRO
SEQRES 6 H 194 VAL PRO GLN LEU LYS SER PHE GLN LYS ILE GLN VAL ARG
SEQRES 7 H 194 LEU VAL ARG GLU LEU GLU LYS LYS PHE SER GLY LYS HIS
SEQRES 8 H 194 VAL VAL PHE ILE ALA GLN ARG ARG ILE LEU PRO LYS PRO
SEQRES 9 H 194 THR ARG LYS SER ARG THR LYS ASN LYS GLN LYS ARG PRO
SEQRES 10 H 194 ARG SER ARG THR LEU THR ALA VAL HIS ASP ALA ILE LEU
SEQRES 11 H 194 GLU ASP LEU VAL PHE PRO SER GLU ILE VAL GLY LYS ARG
SEQRES 12 H 194 ILE ARG VAL LYS LEU ASP GLY SER ARG LEU ILE LYS VAL
SEQRES 13 H 194 HIS LEU ASP LYS ALA GLN GLN ASN ASN VAL GLU HIS LYS
SEQRES 14 H 194 VAL GLU THR PHE SER GLY VAL TYR LYS LYS LEU THR GLY
SEQRES 15 H 194 LYS ASP VAL ASN PHE GLU PHE PRO GLU PHE GLN LEU
SEQRES 1 I 208 MET GLY ILE SER ARG ASP ASN TRP HIS LYS ARG ARG LYS
SEQRES 2 I 208 THR GLY GLY LYS ARG LYS PRO TYR HIS LYS LYS ARG LYS
SEQRES 3 I 208 TYR GLU LEU GLY ARG PRO ALA ALA ASN THR LYS ILE GLY
SEQRES 4 I 208 PRO ARG ARG ILE HIS THR VAL ARG VAL ARG GLY GLY ASN
SEQRES 5 I 208 LYS LYS TYR ARG ALA LEU ARG LEU ASP VAL GLY ASN PHE
SEQRES 6 I 208 SER TRP GLY SER GLU CYS CYS THR ARG LYS THR ARG ILE
SEQRES 7 I 208 ILE ASP VAL VAL TYR ASN ALA SER ASN ASN GLU LEU VAL
SEQRES 8 I 208 ARG THR LYS THR LEU VAL LYS ASN CYS ILE VAL LEU ILE
SEQRES 9 I 208 ASP SER THR PRO TYR ARG GLN TRP TYR GLU SER HIS TYR
SEQRES 10 I 208 ALA LEU PRO LEU GLY ARG LYS LYS GLY ALA LYS LEU THR
SEQRES 11 I 208 PRO GLU GLU GLU GLU ILE LEU ASN LYS LYS ARG SER LYS
SEQRES 12 I 208 LYS ILE GLN LYS LYS TYR ASP GLU ARG LYS LYS ASN ALA
SEQRES 13 I 208 LYS ILE SER SER LEU LEU GLU GLU GLN PHE GLN GLN GLY
SEQRES 14 I 208 LYS LEU LEU ALA CYS ILE ALA SER ARG PRO GLY GLN CYS
SEQRES 15 I 208 GLY ARG ALA ASP GLY TYR VAL LEU GLU GLY LYS GLU LEU
SEQRES 16 I 208 GLU PHE TYR LEU ARG LYS ILE LYS ALA ARG LYS GLY LYS
SEQRES 1 J 194 MET PRO VAL ALA ARG SER TRP VAL CYS ARG LYS THR TYR
SEQRES 2 J 194 VAL THR PRO ARG ARG PRO PHE GLU LYS SER ARG LEU ASP
SEQRES 3 J 194 GLN GLU LEU LYS LEU ILE GLY GLU TYR GLY LEU ARG ASN
SEQRES 4 J 194 LYS ARG GLU VAL TRP ARG VAL LYS PHE THR LEU ALA LYS
SEQRES 5 J 194 ILE ARG LYS ALA ALA ARG GLU LEU LEU THR LEU ASP GLU
SEQRES 6 J 194 LYS ASP PRO ARG ARG LEU PHE GLU GLY ASN ALA LEU LEU
SEQRES 7 J 194 ARG ARG LEU VAL ARG ILE GLY VAL LEU ASP GLU GLY LYS
SEQRES 8 J 194 MET LYS LEU ASP TYR ILE LEU GLY LEU LYS ILE GLU ASP
SEQRES 9 J 194 PHE LEU GLU ARG ARG LEU GLN THR GLN VAL PHE LYS LEU
SEQRES 10 J 194 GLY LEU ALA LYS SER ILE HIS HIS ALA ARG VAL LEU ILE
SEQRES 11 J 194 ARG GLN ARG HIS ILE ARG VAL ARG LYS GLN VAL VAL ASN
SEQRES 12 J 194 ILE PRO SER PHE ILE VAL ARG LEU ASP SER GLN LYS HIS
SEQRES 13 J 194 ILE ASP PHE SER LEU ARG SER PRO TYR GLY GLY GLY ARG
SEQRES 14 J 194 PRO GLY ARG VAL LYS ARG LYS ASN ALA LYS LYS GLY GLN
SEQRES 15 J 194 GLY GLY ALA GLY ALA GLY ASP ASP GLU GLU GLU ASP
SEQRES 1 K 165 MET LEU MET PRO LYS LYS ASN ARG ILE ALA ILE TYR GLU
SEQRES 2 K 165 LEU LEU PHE LYS GLU GLY VAL MET VAL ALA LYS LYS ASP
SEQRES 3 K 165 VAL HIS MET PRO LYS HIS PRO GLU LEU ALA ASP LYS ASN
SEQRES 4 K 165 VAL PRO ASN LEU HIS VAL MET LYS ALA MET GLN SER LEU
SEQRES 5 K 165 LYS SER ARG GLY TYR VAL LYS GLU GLN PHE ALA TRP ARG
SEQRES 6 K 165 HIS PHE TYR TRP TYR LEU THR ASN GLU GLY ILE GLN TYR
SEQRES 7 K 165 LEU ARG ASP TYR LEU HIS LEU PRO PRO GLU ILE VAL PRO
SEQRES 8 K 165 ALA THR LEU ARG ARG SER ARG PRO GLU THR GLY ARG PRO
SEQRES 9 K 165 ARG PRO LYS GLY LEU GLU GLY GLU ARG PRO ALA ARG LEU
SEQRES 10 K 165 THR ARG GLY GLU ALA ASP ARG ASP THR TYR ARG ARG SER
SEQRES 11 K 165 ALA VAL PRO PRO GLY ALA ASP LYS LYS ALA GLU ALA GLY
SEQRES 12 K 165 ALA GLY SER ALA THR GLU PHE GLN PHE ARG GLY GLY PHE
SEQRES 13 K 165 GLY ARG GLY ARG GLY GLN PRO PRO GLN
SEQRES 1 L 158 MET ALA ASP ILE GLN THR GLU ARG ALA TYR GLN LYS GLN
SEQRES 2 L 158 PRO THR ILE PHE GLN ASN LYS LYS ARG VAL LEU LEU GLY
SEQRES 3 L 158 GLU THR GLY LYS GLU LYS LEU PRO ARG TYR TYR LYS ASN
SEQRES 4 L 158 ILE GLY LEU GLY PHE LYS THR PRO LYS GLU ALA ILE GLU
SEQRES 5 L 158 GLY THR TYR ILE ASP LYS LYS CYS PRO PHE THR GLY ASN
SEQRES 6 L 158 VAL SER ILE ARG GLY ARG ILE LEU SER GLY VAL VAL THR
SEQRES 7 L 158 LYS MET LYS MET GLN ARG THR ILE VAL ILE ARG ARG ASP
SEQRES 8 L 158 TYR LEU HIS TYR ILE ARG LYS TYR ASN ARG PHE GLU LYS
SEQRES 9 L 158 ARG HIS LYS ASN MET SER VAL HIS LEU SER PRO CYS PHE
SEQRES 10 L 158 ARG ASP VAL GLN ILE GLY ASP ILE VAL THR VAL GLY GLU
SEQRES 11 L 158 CYS ARG PRO LEU SER LYS THR VAL ARG PHE ASN VAL LEU
SEQRES 12 L 158 LYS VAL THR LYS ALA ALA GLY THR LYS LYS GLN PHE GLN
SEQRES 13 L 158 LYS PHE
SEQRES 1 M 132 MET ALA GLU GLU GLY ILE ALA ALA GLY GLY VAL MET ASP
SEQRES 2 M 132 VAL ASN THR ALA LEU GLN GLU VAL LEU LYS THR ALA LEU
SEQRES 3 M 132 ILE HIS ASP GLY LEU ALA ARG GLY ILE ARG GLU ALA ALA
SEQRES 4 M 132 LYS ALA LEU ASP LYS ARG GLN ALA HIS LEU CYS VAL LEU
SEQRES 5 M 132 ALA SER ASN CYS ASP GLU PRO MET TYR VAL LYS LEU VAL
SEQRES 6 M 132 GLU ALA LEU CYS ALA GLU HIS GLN ILE ASN LEU ILE LYS
SEQRES 7 M 132 VAL ASP ASP ASN LYS LYS LEU GLY GLU TRP VAL GLY LEU
SEQRES 8 M 132 CYS LYS ILE ASP ARG GLU GLY LYS PRO ARG LYS VAL VAL
SEQRES 9 M 132 GLY CYS SER CYS VAL VAL VAL LYS ASP TYR GLY LYS GLU
SEQRES 10 M 132 SER GLN ALA LYS ASP VAL ILE GLU GLU TYR PHE LYS CYS
SEQRES 11 M 132 LYS LYS
SEQRES 1 N 151 MET GLY ARG MET HIS ALA PRO GLY LYS GLY LEU SER GLN
SEQRES 2 N 151 SER ALA LEU PRO TYR ARG ARG SER VAL PRO THR TRP LEU
SEQRES 3 N 151 LYS LEU THR SER ASP ASP VAL LYS GLU GLN ILE TYR LYS
SEQRES 4 N 151 LEU ALA LYS LYS GLY LEU THR PRO SER GLN ILE GLY VAL
SEQRES 5 N 151 ILE LEU ARG ASP SER HIS GLY VAL ALA GLN VAL ARG PHE
SEQRES 6 N 151 VAL THR GLY ASN LYS ILE LEU ARG ILE LEU LYS SER LYS
SEQRES 7 N 151 GLY LEU ALA PRO ASP LEU PRO GLU ASP LEU TYR HIS LEU
SEQRES 8 N 151 ILE LYS LYS ALA VAL ALA VAL ARG LYS HIS LEU GLU ARG
SEQRES 9 N 151 ASN ARG LYS ASP LYS ASP ALA LYS PHE ARG LEU ILE LEU
SEQRES 10 N 151 ILE GLU SER ARG ILE HIS ARG LEU ALA ARG TYR TYR LYS
SEQRES 11 N 151 THR LYS ARG VAL LEU PRO PRO ASN TRP LYS TYR GLU SER
SEQRES 12 N 151 SER THR ALA SER ALA LEU VAL ALA
SEQRES 1 O 151 MET ALA PRO ARG LYS GLY LYS GLU LYS LYS GLU GLU GLN
SEQRES 2 O 151 VAL ILE SER LEU GLY PRO GLN VAL ALA GLU GLY GLU ASN
SEQRES 3 O 151 VAL PHE GLY VAL CYS HIS ILE PHE ALA SER PHE ASN ASP
SEQRES 4 O 151 THR PHE VAL HIS VAL THR ASP LEU SER GLY LYS GLU THR
SEQRES 5 O 151 ILE CYS ARG VAL THR GLY GLY MET LYS VAL LYS ALA ASP
SEQRES 6 O 151 ARG ASP GLU SER SER PRO TYR ALA ALA MET LEU ALA ALA
SEQRES 7 O 151 GLN ASP VAL ALA GLN ARG CYS LYS GLU LEU GLY ILE THR
SEQRES 8 O 151 ALA LEU HIS ILE LYS LEU ARG ALA THR GLY GLY ASN ARG
SEQRES 9 O 151 THR LYS THR PRO GLY PRO GLY ALA GLN SER ALA LEU ARG
SEQRES 10 O 151 ALA LEU ALA ARG SER GLY MET LYS ILE GLY ARG ILE GLU
SEQRES 11 O 151 ASP VAL THR PRO ILE PRO SER ASP SER THR ARG ARG LYS
SEQRES 12 O 151 GLY GLY ARG ARG GLY ARG ARG LEU
SEQRES 1 P 145 MET ALA GLU VAL GLU GLN LYS LYS LYS ARG THR PHE ARG
SEQRES 2 P 145 LYS PHE THR TYR ARG GLY VAL ASP LEU ASP GLN LEU LEU
SEQRES 3 P 145 ASP MET SER TYR GLU GLN LEU MET GLN LEU TYR SER ALA
SEQRES 4 P 145 ARG GLN ARG ARG ARG LEU ASN ARG GLY LEU ARG ARG LYS
SEQRES 5 P 145 GLN HIS SER LEU LEU LYS ARG LEU ARG LYS ALA LYS LYS
SEQRES 6 P 145 GLU ALA PRO PRO MET GLU LYS PRO GLU VAL VAL LYS THR
SEQRES 7 P 145 HIS LEU ARG ASP MET ILE ILE LEU PRO GLU MET VAL GLY
SEQRES 8 P 145 SER MET VAL GLY VAL TYR ASN GLY LYS THR PHE ASN GLN
SEQRES 9 P 145 VAL GLU ILE LYS PRO GLU MET ILE GLY HIS TYR LEU GLY
SEQRES 10 P 145 GLU PHE SER ILE THR TYR LYS PRO VAL LYS HIS GLY ARG
SEQRES 11 P 145 PRO GLY ILE GLY ALA THR HIS SER SER ARG PHE ILE PRO
SEQRES 12 P 145 LEU LYS
SEQRES 1 Q 146 MET PRO SER LYS GLY PRO LEU GLN SER VAL GLN VAL PHE
SEQRES 2 Q 146 GLY ARG LYS LYS THR ALA THR ALA VAL ALA HIS CYS LYS
SEQRES 3 Q 146 ARG GLY ASN GLY LEU ILE LYS VAL ASN GLY ARG PRO LEU
SEQRES 4 Q 146 GLU MET ILE GLU PRO ARG THR LEU GLN TYR LYS LEU LEU
SEQRES 5 Q 146 GLU PRO VAL LEU LEU LEU GLY LYS GLU ARG PHE ALA GLY
SEQRES 6 Q 146 VAL ASP ILE ARG VAL ARG VAL LYS GLY GLY GLY HIS VAL
SEQRES 7 Q 146 ALA GLN ILE TYR ALA ILE ARG GLN SER ILE SER LYS ALA
SEQRES 8 Q 146 LEU VAL ALA TYR TYR GLN LYS TYR VAL ASP GLU ALA SER
SEQRES 9 Q 146 LYS LYS GLU ILE LYS ASP ILE LEU ILE GLN TYR ASP ARG
SEQRES 10 Q 146 THR LEU LEU VAL ALA ASP PRO ARG ARG CYS GLU SER LYS
SEQRES 11 Q 146 LYS PHE GLY GLY PRO GLY ALA ARG ALA ARG TYR GLN LYS
SEQRES 12 Q 146 SER TYR ARG
SEQRES 1 R 135 MET GLY ARG VAL ARG THR LYS THR VAL LYS LYS ALA ALA
SEQRES 2 R 135 ARG VAL ILE ILE GLU LYS TYR TYR THR ARG LEU GLY ASN
SEQRES 3 R 135 ASP PHE HIS THR ASN LYS ARG VAL CYS GLU GLU ILE ALA
SEQRES 4 R 135 ILE ILE PRO SER LYS LYS LEU ARG ASN LYS ILE ALA GLY
SEQRES 5 R 135 TYR VAL THR HIS LEU MET LYS ARG ILE GLN ARG GLY PRO
SEQRES 6 R 135 VAL ARG GLY ILE SER ILE LYS LEU GLN GLU GLU GLU ARG
SEQRES 7 R 135 GLU ARG ARG ASP ASN TYR VAL PRO GLU VAL SER ALA LEU
SEQRES 8 R 135 ASP GLN GLU ILE ILE GLU VAL ASP PRO ASP THR LYS GLU
SEQRES 9 R 135 MET LEU LYS LEU LEU ASP PHE GLY SER LEU SER ASN LEU
SEQRES 10 R 135 GLN VAL THR GLN PRO THR VAL GLY MET ASN PHE LYS THR
SEQRES 11 R 135 PRO ARG GLY PRO VAL
SEQRES 1 S 152 MET SER LEU VAL ILE PRO GLU LYS PHE GLN HIS ILE LEU
SEQRES 2 S 152 ARG VAL LEU ASN THR ASN ILE ASP GLY ARG ARG LYS ILE
SEQRES 3 S 152 ALA PHE ALA ILE THR ALA ILE LYS GLY VAL GLY ARG ARG
SEQRES 4 S 152 TYR ALA HIS VAL VAL LEU ARG LYS ALA ASP ILE ASP LEU
SEQRES 5 S 152 THR LYS ARG ALA GLY GLU LEU THR GLU ASP GLU VAL GLU
SEQRES 6 S 152 ARG VAL ILE THR ILE MET GLN ASN PRO ARG GLN TYR LYS
SEQRES 7 S 152 ILE PRO ASP TRP PHE LEU ASN ARG GLN LYS ASP VAL LYS
SEQRES 8 S 152 ASP GLY LYS TYR SER GLN VAL LEU ALA ASN GLY LEU ASP
SEQRES 9 S 152 ASN LYS LEU ARG GLU ASP LEU GLU ARG LEU LYS LYS ILE
SEQRES 10 S 152 ARG ALA HIS ARG GLY LEU ARG HIS PHE TRP GLY LEU ARG
SEQRES 11 S 152 VAL ARG GLY GLN HIS THR LYS THR THR GLY ARG ARG GLY
SEQRES 12 S 152 ARG THR VAL GLY VAL SER LYS LYS LYS
SEQRES 1 T 145 MET PRO GLY VAL THR VAL LYS ASP VAL ASN GLN GLN GLU
SEQRES 2 T 145 PHE VAL ARG ALA LEU ALA ALA PHE LEU LYS LYS SER GLY
SEQRES 3 T 145 LYS LEU LYS VAL PRO GLU TRP VAL ASP THR VAL LYS LEU
SEQRES 4 T 145 ALA LYS HIS LYS GLU LEU ALA PRO TYR ASP GLU ASN TRP
SEQRES 5 T 145 PHE TYR THR ARG ALA ALA SER THR ALA ARG HIS LEU TYR
SEQRES 6 T 145 LEU ARG GLY GLY ALA GLY VAL GLY SER MET THR LYS ILE
SEQRES 7 T 145 TYR GLY GLY ARG GLN ARG ASN GLY VAL MET PRO SER HIS
SEQRES 8 T 145 PHE SER ARG GLY SER LYS SER VAL ALA ARG ARG VAL LEU
SEQRES 9 T 145 GLN ALA LEU GLU GLY LEU LYS MET VAL GLU LYS ASP GLN
SEQRES 10 T 145 ASP GLY GLY ARG LYS LEU THR PRO GLN GLY GLN ARG ASP
SEQRES 11 T 145 LEU ASP ARG ILE ALA GLY GLN VAL ALA ALA ALA ASN LYS
SEQRES 12 T 145 LYS HIS
SEQRES 1 U 119 MET ALA PHE LYS ASP THR GLY LYS THR PRO VAL GLU PRO
SEQRES 2 U 119 GLU VAL ALA ILE HIS ARG ILE ARG ILE THR LEU THR SER
SEQRES 3 U 119 ARG ASN VAL LYS SER LEU GLU LYS VAL CYS ALA ASP LEU
SEQRES 4 U 119 ILE ARG GLY ALA LYS GLU LYS ASN LEU LYS VAL LYS GLY
SEQRES 5 U 119 PRO VAL ARG MET PRO THR LYS THR LEU ARG ILE THR THR
SEQRES 6 U 119 ARG LYS THR PRO CYS GLY GLU GLY SER LYS THR TRP ASP
SEQRES 7 U 119 ARG PHE GLN MET ARG ILE HIS LYS ARG LEU ILE ASP LEU
SEQRES 8 U 119 HIS SER PRO SER GLU ILE VAL LYS GLN ILE THR SER ILE
SEQRES 9 U 119 SER ILE GLU PRO GLY VAL GLU VAL GLU VAL THR ILE ALA
SEQRES 10 U 119 ASP ALA
SEQRES 1 V 83 MET GLN ASN ASP ALA GLY GLU PHE VAL ASP LEU TYR VAL
SEQRES 2 V 83 PRO ARG LYS CYS SER ALA SER ASN ARG ILE ILE GLY ALA
SEQRES 3 V 83 LYS ASP HIS ALA SER ILE GLN MET ASN VAL ALA GLU VAL
SEQRES 4 V 83 ASP LYS VAL THR GLY ARG PHE ASN GLY GLN PHE LYS THR
SEQRES 5 V 83 TYR ALA ILE CYS GLY ALA ILE ARG ARG MET GLY GLU SER
SEQRES 6 V 83 ASP ASP SER ILE LEU ARG LEU ALA LYS ALA ASP GLY ILE
SEQRES 7 V 83 VAL SER LYS ASN PHE
SEQRES 1 W 130 MET VAL ARG MET ASN VAL LEU ALA ASP ALA LEU LYS SER
SEQRES 2 W 130 ILE ASN ASN ALA GLU LYS ARG GLY LYS ARG GLN VAL LEU
SEQRES 3 W 130 ILE ARG PRO CYS SER LYS VAL ILE VAL ARG PHE LEU THR
SEQRES 4 W 130 VAL MET MET LYS HIS GLY TYR ILE GLY GLU PHE GLU ILE
SEQRES 5 W 130 ILE ASP ASP HIS ARG ALA GLY LYS ILE VAL VAL ASN LEU
SEQRES 6 W 130 THR GLY ARG LEU ASN LYS CYS GLY VAL ILE SER PRO ARG
SEQRES 7 W 130 PHE ASP VAL GLN LEU LYS ASP LEU GLU LYS TRP GLN ASN
SEQRES 8 W 130 ASN LEU LEU PRO SER ARG GLN PHE GLY PHE ILE VAL LEU
SEQRES 9 W 130 THR THR SER ALA GLY ILE MET ASP HIS GLU GLU ALA ARG
SEQRES 10 W 130 ARG LYS HIS THR GLY GLY LYS ILE LEU GLY PHE PHE PHE
SEQRES 1 X 143 MET GLY LYS CYS ARG GLY LEU ARG THR ALA ARG LYS LEU
SEQRES 2 X 143 ARG SER HIS ARG ARG ASP GLN LYS TRP HIS ASP LYS GLN
SEQRES 3 X 143 TYR LYS LYS ALA HIS LEU GLY THR ALA LEU LYS ALA ASN
SEQRES 4 X 143 PRO PHE GLY GLY ALA SER HIS ALA LYS GLY ILE VAL LEU
SEQRES 5 X 143 GLU LYS VAL GLY VAL GLU ALA LYS GLN PRO ASN SER ALA
SEQRES 6 X 143 ILE ARG LYS CYS VAL ARG VAL GLN LEU ILE LYS ASN GLY
SEQRES 7 X 143 LYS LYS ILE THR ALA PHE VAL PRO ASN ASP GLY CYS LEU
SEQRES 8 X 143 ASN PHE ILE GLU GLU ASN ASP GLU VAL LEU VAL ALA GLY
SEQRES 9 X 143 PHE GLY ARG LYS GLY HIS ALA VAL GLY ASP ILE PRO GLY
SEQRES 10 X 143 VAL ARG PHE LYS VAL VAL LYS VAL ALA ASN VAL SER LEU
SEQRES 11 X 143 LEU ALA LEU TYR LYS GLY LYS LYS GLU ARG PRO ARG SER
SEQRES 1 Y 133 MET ASN ASP THR VAL THR ILE ARG THR ARG LYS PHE MET
SEQRES 2 Y 133 THR ASN ARG LEU LEU GLN ARG LYS GLN MET VAL ILE ASP
SEQRES 3 Y 133 VAL LEU HIS PRO GLY LYS ALA THR VAL PRO LYS THR GLU
SEQRES 4 Y 133 ILE ARG GLU LYS LEU ALA LYS MET TYR LYS THR THR PRO
SEQRES 5 Y 133 ASP VAL ILE PHE VAL PHE GLY PHE ARG THR HIS PHE GLY
SEQRES 6 Y 133 GLY GLY LYS THR THR GLY PHE GLY MET ILE TYR ASP SER
SEQRES 7 Y 133 LEU ASP TYR ALA LYS LYS ASN GLU PRO LYS HIS ARG LEU
SEQRES 8 Y 133 ALA ARG HIS GLY LEU TYR GLU LYS LYS LYS THR SER ARG
SEQRES 9 Y 133 LYS GLN ARG LYS GLU ARG LYS ASN ARG MET LYS LYS VAL
SEQRES 10 Y 133 ARG GLY THR ALA LYS ALA ASN VAL GLY ALA GLY LYS LYS
SEQRES 11 Y 133 PRO LYS GLU
SEQRES 1 Z 125 MET PRO PRO LYS ASP ASP LYS LYS LYS LYS ASP ALA GLY
SEQRES 2 Z 125 LYS SER ALA LYS LYS ASP LYS ASP PRO VAL ASN LYS SER
SEQRES 3 Z 125 GLY GLY LYS ALA LYS LYS LYS LYS TRP SER LYS GLY LYS
SEQRES 4 Z 125 VAL ARG ASP LYS LEU ASN ASN LEU VAL LEU PHE ASP LYS
SEQRES 5 Z 125 ALA THR TYR ASP LYS LEU CYS LYS GLU VAL PRO ASN TYR
SEQRES 6 Z 125 LYS LEU ILE THR PRO ALA VAL VAL SER GLU ARG LEU LYS
SEQRES 7 Z 125 ILE ARG GLY SER LEU ALA ARG ALA ALA LEU GLN GLU LEU
SEQRES 8 Z 125 LEU SER LYS GLY LEU ILE LYS LEU VAL SER LYS HIS ARG
SEQRES 9 Z 125 ALA GLN VAL ILE TYR THR ARG ASN THR LYS GLY GLY ASP
SEQRES 10 Z 125 ALA PRO ALA ALA GLY GLU ASP ALA
SEQRES 1 b 84 MET PRO LEU ALA LYS ASP LEU LEU HIS PRO SER PRO GLU
SEQRES 2 b 84 GLU GLU LYS ARG LYS HIS LYS LYS LYS ARG LEU VAL GLN
SEQRES 3 b 84 SER PRO ASN SER TYR PHE MET ASP VAL LYS CYS PRO GLY
SEQRES 4 b 84 CYS TYR LYS ILE THR THR VAL PHE SER HIS ALA GLN THR
SEQRES 5 b 84 VAL VAL LEU CYS VAL GLY CYS SER THR VAL LEU CYS GLN
SEQRES 6 b 84 PRO THR GLY GLY LYS ALA ARG LEU THR GLU GLY CYS SER
SEQRES 7 b 84 PHE ARG ARG LYS GLN HIS
SEQRES 1 c 69 MET ASP THR SER ARG VAL GLN PRO ILE LYS LEU ALA ARG
SEQRES 2 c 69 VAL THR LYS VAL LEU GLY ARG THR GLY SER GLN GLY GLN
SEQRES 3 c 69 CYS THR GLN VAL ARG VAL GLU PHE MET ASP ASP THR SER
SEQRES 4 c 69 ARG SER ILE ILE ARG ASN VAL LYS GLY PRO VAL ARG GLU
SEQRES 5 c 69 GLY ASP VAL LEU THR LEU LEU GLU SER GLU ARG GLU ALA
SEQRES 6 c 69 ARG ARG LEU ARG
SEQRES 1 d 56 MET GLY HIS GLN GLN LEU TYR TRP SER HIS PRO ARG LYS
SEQRES 2 d 56 PHE GLY GLN GLY SER ARG SER CYS ARG VAL CYS SER ASN
SEQRES 3 d 56 ARG HIS GLY LEU ILE ARG LYS TYR GLY LEU ASN MET CYS
SEQRES 4 d 56 ARG GLN CYS PHE ARG GLN TYR ALA LYS ASP ILE GLY PHE
SEQRES 5 d 56 ILE LYS LEU ASP
SEQRES 1 e 59 LYS VAL HIS GLY SER LEU ALA ARG ALA GLY LYS VAL ARG
SEQRES 2 e 59 GLY GLN THR PRO LYS VAL ALA LYS GLN GLU LYS LYS LYS
SEQRES 3 e 59 LYS LYS THR GLY ARG ALA LYS ARG ARG MET GLN TYR ASN
SEQRES 4 e 59 ARG ARG PHE VAL ASN VAL VAL PRO THR PHE GLY LYS LYS
SEQRES 5 e 59 LYS GLY PRO ASN ALA ASN SER
SEQRES 1 f 156 MET GLN ILE PHE VAL LYS THR LEU THR GLY LYS THR ILE
SEQRES 2 f 156 THR LEU GLU VAL GLU PRO SER ASP THR ILE GLU ASN VAL
SEQRES 3 f 156 LYS ALA LYS ILE GLN ASP LYS GLU GLY ILE PRO PRO ASP
SEQRES 4 f 156 GLN GLN ARG LEU ILE PHE ALA GLY LYS GLN LEU GLU ASP
SEQRES 5 f 156 GLY ARG THR LEU SER ASP TYR ASN ILE GLN LYS GLU SER
SEQRES 6 f 156 THR LEU HIS LEU VAL LEU ARG LEU ARG GLY GLY ALA LYS
SEQRES 7 f 156 LYS ARG LYS LYS LYS SER CYS THR THR PRO LYS LYS ASN
SEQRES 8 f 156 LYS HIS LYS ARG LYS LYS VAL LYS LEU ALA VAL LEU LYS
SEQRES 9 f 156 TYR TYR LYS VAL ASP GLU ASN GLY LYS ILE SER ARG LEU
SEQRES 10 f 156 ARG ARG GLU CYS PRO SER ASP GLU CYS GLY ALA GLY VAL
SEQRES 11 f 156 PHE MET ALA SER HIS PHE ASP ARG HIS TYR CYS GLY LYS
SEQRES 12 f 156 CYS CYS LEU THR TYR CYS PHE ASN LYS PRO GLU ASP LYS
SEQRES 1 g 317 MET THR GLU GLN MET THR LEU ARG GLY THR LEU LYS GLY
SEQRES 2 g 317 HIS ASN GLY TRP VAL THR GLN ILE ALA THR THR PRO GLN
SEQRES 3 g 317 PHE PRO ASP MET ILE LEU SER ALA SER ARG ASP LYS THR
SEQRES 4 g 317 ILE ILE MET TRP LYS LEU THR ARG ASP GLU THR ASN TYR
SEQRES 5 g 317 GLY ILE PRO GLN ARG ALA LEU ARG GLY HIS SER HIS PHE
SEQRES 6 g 317 VAL SER ASP VAL VAL ILE SER SER ASP GLY GLN PHE ALA
SEQRES 7 g 317 LEU SER GLY SER TRP ASP GLY THR LEU ARG LEU TRP ASP
SEQRES 8 g 317 LEU THR THR GLY THR THR THR ARG ARG PHE VAL GLY HIS
SEQRES 9 g 317 THR LYS ASP VAL LEU SER VAL ALA PHE SER SER ASP ASN
SEQRES 10 g 317 ARG GLN ILE VAL SER GLY SER ARG ASP LYS THR ILE LYS
SEQRES 11 g 317 LEU TRP ASN THR LEU GLY VAL CYS LYS TYR THR VAL GLN
SEQRES 12 g 317 ASP GLU SER HIS SER GLU TRP VAL SER CYS VAL ARG PHE
SEQRES 13 g 317 SER PRO ASN SER SER ASN PRO ILE ILE VAL SER CYS GLY
SEQRES 14 g 317 TRP ASP LYS LEU VAL LYS VAL TRP ASN LEU ALA ASN CYS
SEQRES 15 g 317 LYS LEU LYS THR ASN HIS ILE GLY HIS THR GLY TYR LEU
SEQRES 16 g 317 ASN THR VAL THR VAL SER PRO ASP GLY SER LEU CYS ALA
SEQRES 17 g 317 SER GLY GLY LYS ASP GLY GLN ALA MET LEU TRP ASP LEU
SEQRES 18 g 317 ASN GLU GLY LYS HIS LEU TYR THR LEU ASP GLY GLY ASP
SEQRES 19 g 317 ILE ILE ASN ALA LEU CYS PHE SER PRO ASN ARG TYR TRP
SEQRES 20 g 317 LEU CYS ALA ALA THR GLY PRO SER ILE LYS ILE TRP ASP
SEQRES 21 g 317 LEU GLU GLY LYS ILE ILE VAL ASP GLU LEU LYS GLN GLU
SEQRES 22 g 317 VAL ILE SER THR SER SER LYS ALA GLU PRO PRO GLN CYS
SEQRES 23 g 317 THR SER LEU ALA TRP SER ALA ASP GLY GLN THR LEU PHE
SEQRES 24 g 317 ALA GLY TYR THR ASP ASN LEU VAL ARG VAL TRP GLN VAL
SEQRES 25 g 317 THR ILE GLY THR ARG
SEQRES 1 x 252 MET GLU SER GLU MET GLU THR GLN SER ALA ARG ALA GLU
SEQRES 2 x 252 GLU GLY PHE THR GLN VAL THR ARG LYS GLY GLY ARG ARG
SEQRES 3 x 252 ALA LYS LYS ARG GLN ALA GLU GLN LEU SER ALA ALA GLY
SEQRES 4 x 252 GLU GLY GLY ASP ALA GLY ARG MET ASP THR GLU GLU ALA
SEQRES 5 x 252 ARG PRO ALA LYS ARG PRO VAL PHE PRO PRO LEU CYS GLY
SEQRES 6 x 252 ASP GLY LEU LEU SER GLY LYS GLU GLU THR ARG LYS ILE
SEQRES 7 x 252 PRO VAL PRO ALA ASN ARG TYR THR PRO LEU LYS GLU ASN
SEQRES 8 x 252 TRP MET LYS ILE PHE THR PRO ILE VAL GLU HIS LEU GLY
SEQRES 9 x 252 LEU GLN ILE ARG PHE ASN LEU LYS SER ARG ASN VAL GLU
SEQRES 10 x 252 ILE ARG THR CYS LYS GLU THR LYS ASP VAL SER ALA LEU
SEQRES 11 x 252 THR LYS ALA ALA ASP PHE VAL LYS ALA PHE ILE LEU GLY
SEQRES 12 x 252 PHE GLN VAL GLU ASP ALA LEU ALA LEU ILE ARG LEU ASP
SEQRES 13 x 252 ASP LEU PHE LEU GLU SER PHE GLU ILE THR ASP VAL LYS
SEQRES 14 x 252 PRO LEU LYS GLY ASP HIS LEU SER ARG ALA ILE GLY ARG
SEQRES 15 x 252 ILE ALA GLY LYS GLY GLY LYS THR LYS PHE THR ILE GLU
SEQRES 16 x 252 ASN VAL THR ARG THR ARG ILE VAL LEU ALA ASP VAL LYS
SEQRES 17 x 252 VAL HIS ILE LEU GLY SER PHE GLN ASN ILE LYS MET ALA
SEQRES 18 x 252 ARG THR ALA ILE CYS ASN LEU ILE LEU GLY ASN PRO PRO
SEQRES 19 x 252 SER LYS VAL TYR GLY ASN ILE ARG ALA VAL ALA SER ARG
SEQRES 20 x 252 SER ALA ASP ARG PHE
SEQRES 1 y 412 MET ALA PRO VAL GLU HIS VAL VAL ALA ASP ALA GLY ALA
SEQRES 2 y 412 PHE LEU ARG HIS ALA ALA LEU GLN ASP ILE GLY LYS ASN
SEQRES 3 y 412 ILE TYR THR ILE ARG GLU VAL VAL THR GLU ILE ARG ASP
SEQRES 4 y 412 LYS ALA THR ARG ARG ARG LEU ALA VAL LEU PRO TYR GLU
SEQRES 5 y 412 LEU ARG PHE LYS GLU PRO LEU PRO GLU TYR VAL ARG LEU
SEQRES 6 y 412 VAL THR GLU PHE SER LYS LYS THR GLY ASP TYR PRO SER
SEQRES 7 y 412 LEU SER ALA THR ASP ILE GLN VAL LEU ALA LEU THR TYR
SEQRES 8 y 412 GLN LEU GLU ALA GLU PHE VAL GLY VAL SER HIS LEU LYS
SEQRES 9 y 412 GLN GLU PRO GLN LYS VAL LYS VAL SER SER SER ILE GLN
SEQRES 10 y 412 HIS PRO GLU THR PRO LEU HIS ILE SER GLY PHE HIS LEU
SEQRES 11 y 412 PRO TYR LYS PRO LYS PRO PRO GLN GLU THR GLU LYS GLY
SEQRES 12 y 412 HIS SER ALA CYS GLU PRO GLU ASN LEU GLU PHE SER SER
SEQRES 13 y 412 PHE MET PHE TRP ARG ASN PRO LEU PRO ASN ILE ASP HIS
SEQRES 14 y 412 GLU LEU GLN GLU LEU LEU ILE ASP ARG GLY GLU ASP VAL
SEQRES 15 y 412 PRO SER GLU GLU GLU GLU GLU GLU GLU ASN GLY PHE GLU
SEQRES 16 y 412 ASP ARG LYS ASP ASP SER ASP ASP ASP GLY GLY GLY TRP
SEQRES 17 y 412 ILE THR PRO SER ASN ILE LYS GLN ILE GLN GLN GLU LEU
SEQRES 18 y 412 GLU GLN CYS ASP VAL PRO GLU ASP VAL ARG VAL GLY CYS
SEQRES 19 y 412 LEU THR THR ASP PHE ALA MET GLN ASN VAL LEU LEU GLN
SEQRES 20 y 412 MET GLY LEU HIS VAL LEU ALA VAL ASN GLY MET LEU ILE
SEQRES 21 y 412 ARG GLU ALA ARG SER TYR ILE LEU ARG CYS HIS GLY CYS
SEQRES 22 y 412 PHE LYS THR THR SER ASP MET SER ARG VAL PHE CYS SER
SEQRES 23 y 412 HIS CYS GLY ASN LYS THR LEU LYS LYS VAL SER VAL THR
SEQRES 24 y 412 VAL SER ASP ASP GLY THR LEU HIS MET HIS PHE SER ARG
SEQRES 25 y 412 ASN PRO LYS VAL LEU ASN PRO ARG GLY LEU ARG TYR SER
SEQRES 26 y 412 LEU PRO THR PRO LYS GLY GLY LYS TYR ALA ILE ASN PRO
SEQRES 27 y 412 HIS LEU THR GLU ASP GLN ARG PHE PRO GLN LEU ARG LEU
SEQRES 28 y 412 SER GLN LYS ALA ARG GLN LYS THR ASN VAL PHE ALA PRO
SEQRES 29 y 412 ASP TYR ILE ALA GLY VAL SER PRO PHE VAL GLU ASN ASP
SEQRES 30 y 412 ILE SER SER ARG SER ALA THR LEU GLN VAL ARG ASP SER
SEQRES 31 y 412 THR LEU GLY ALA GLY ARG ARG ARG LEU ASN PRO ASN ALA
SEQRES 32 y 412 SER ARG LYS LYS PHE VAL LYS LYS ARG
SEQRES 1 z 568 MET ASP TYR ARG ARG LEU LEU MET SER ARG VAL VAL PRO
SEQRES 2 z 568 GLY GLN PHE ASP ASP ALA ASP SER SER ASP SER GLU ASN
SEQRES 3 z 568 ARG ASP LEU LYS THR VAL LYS GLU LYS ASP ASP ILE LEU
SEQRES 4 z 568 PHE GLU ASP LEU GLN ASP ASN VAL ASN GLU ASN GLY GLU
SEQRES 5 z 568 GLY GLU ILE GLU ASP GLU GLU GLU GLU GLY TYR ASP ASP
SEQRES 6 z 568 ASP ASP ASP ASP TRP ASP TRP ASP GLU GLY VAL GLY LYS
SEQRES 7 z 568 LEU ALA LYS GLY TYR VAL TRP ASN GLY GLY SER ASN PRO
SEQRES 8 z 568 GLN ALA ASN ARG GLN THR SER ASP SER SER SER ALA LYS
SEQRES 9 z 568 MET SER THR PRO ALA ASP LYS VAL LEU ARG LYS PHE GLU
SEQRES 10 z 568 ASN LYS ILE ASN LEU ASP LYS LEU ASN VAL THR ASP SER
SEQRES 11 z 568 VAL ILE ASN LYS VAL THR GLU LYS SER ARG GLN LYS GLU
SEQRES 12 z 568 ALA ASP MET TYR ARG ILE LYS ASP LYS ALA ASP ARG ALA
SEQRES 13 z 568 THR VAL GLU GLN VAL LEU ASP PRO ARG THR ARG MET ILE
SEQRES 14 z 568 LEU PHE LYS MET LEU THR ARG GLY ILE ILE THR GLU ILE
SEQRES 15 z 568 ASN GLY CYS ILE SER THR GLY LYS GLU ALA ASN VAL TYR
SEQRES 16 z 568 HIS ALA SER THR ALA ASN GLY GLU SER ARG ALA ILE LYS
SEQRES 17 z 568 ILE TYR LYS THR SER ILE LEU VAL PHE LYS ASP ARG ASP
SEQRES 18 z 568 LYS TYR VAL SER GLY GLU PHE ARG PHE ARG HIS GLY TYR
SEQRES 19 z 568 CYS LYS GLY ASN PRO ARG LYS MET VAL LYS THR TRP ALA
SEQRES 20 z 568 GLU LYS GLU MET ARG ASN LEU ILE ARG LEU ASN THR ALA
SEQRES 21 z 568 GLU ILE PRO CYS PRO GLU PRO ILE MET LEU ARG SER HIS
SEQRES 22 z 568 VAL LEU VAL MET SER PHE ILE GLY LYS ASP ASP MET PRO
SEQRES 23 z 568 ALA PRO LEU LEU LYS ASN VAL GLN LEU SER GLU SER LYS
SEQRES 24 z 568 ALA ARG GLU LEU TYR LEU GLN VAL ILE GLN TYR MET ARG
SEQRES 25 z 568 ARG MET TYR GLN ASP ALA ARG LEU VAL HIS ALA ASP LEU
SEQRES 26 z 568 SER GLU PHE ASN MET LEU TYR HIS GLY GLY GLY VAL TYR
SEQRES 27 z 568 ILE ILE ASP VAL SER GLN SER VAL GLU HIS ASP HIS PRO
SEQRES 28 z 568 HIS ALA LEU GLU PHE LEU ARG LYS ASP CYS ALA ASN VAL
SEQRES 29 z 568 ASN ASP PHE PHE MET ARG HIS SER VAL ALA VAL MET THR
SEQRES 30 z 568 VAL ARG GLU LEU PHE GLU PHE VAL THR ASP PRO SER ILE
SEQRES 31 z 568 THR HIS GLU ASN MET ASP ALA TYR LEU SER LYS ALA MET
SEQRES 32 z 568 GLU ILE ALA SER GLN ARG THR LYS GLU GLU ARG SER SER
SEQRES 33 z 568 GLN ASP HIS VAL ASP GLU GLU VAL PHE LYS ARG ALA TYR
SEQRES 34 z 568 ILE PRO ARG THR LEU ASN GLU VAL LYS ASN TYR GLU ARG
SEQRES 35 z 568 ASP MET ASP ILE ILE MET LYS LEU LYS GLU GLU ASP MET
SEQRES 36 z 568 ALA MET ASN ALA GLN GLN ASP ASN ILE LEU TYR GLN THR
SEQRES 37 z 568 VAL THR GLY LEU LYS LYS ASP LEU SER GLY VAL GLN LYS
SEQRES 38 z 568 VAL PRO ALA LEU LEU GLU ASN GLN VAL GLU GLU ARG THR
SEQRES 39 z 568 CYS SER ASP SER GLU ASP ILE GLY SER SER GLU CYS SER
SEQRES 40 z 568 ASP THR ASP SER GLU GLU GLN GLY ASP HIS ALA ARG PRO
SEQRES 41 z 568 LYS LYS HIS THR THR ASP PRO ASP ILE ASP LYS LYS GLU
SEQRES 42 z 568 ARG LYS LYS MET VAL LYS GLU ALA GLN ARG GLU LYS ARG
SEQRES 43 z 568 LYS ASN LYS ILE PRO LYS HIS VAL LYS LYS ARG LYS GLU
SEQRES 44 z 568 LYS THR ALA LYS THR LYS LYS GLY LYS
HET ZN d 201 1
HET ZN f 201 1
HET ZN y 500 1
HETNAM ZN ZINC ION
FORMUL 37 ZN 3(ZN 2+)
HELIX 1 AA1 LYS A 11 GLY A 22 1 12
HELIX 2 AA2 ASP A 31 GLN A 36 5 6
HELIX 3 AA3 ASN A 70 ALA A 72 5 3
HELIX 4 AA4 GLY A 83 ALA A 93 1 11
HELIX 5 AA5 HIS A 131 GLU A 136 1 6
HELIX 6 AA6 ALA A 137 TYR A 139 5 3
HELIX 7 AA7 GLY A 167 TRP A 175 1 9
HELIX 8 AA8 ARG A 180 MET A 185 1 6
HELIX 9 AA9 PRO A 207 LYS A 212 1 6
HELIX 10 AB1 ASP B 23 SER B 26 5 4
HELIX 11 AB2 THR B 106 SER B 112 1 7
HELIX 12 AB3 GLN B 157 ARG B 162 1 6
HELIX 13 AB4 LYS B 167 MET B 172 1 6
HELIX 14 AB5 MET B 172 GLN B 177 1 6
HELIX 15 AB6 VAL B 184 ILE B 189 1 6
HELIX 16 AB7 ILE B 193 ALA B 200 1 8
HELIX 17 AB8 GLY B 226 LEU B 231 1 6
HELIX 18 AB9 LEU C 66 ASP C 72 1 7
HELIX 19 AC1 SER C 77 ILE C 81 5 5
HELIX 20 AC2 SER C 91 LEU C 98 1 8
HELIX 21 AC3 GLU C 146 GLY C 153 1 8
HELIX 22 AC4 ALA C 158 ILE C 162 5 5
HELIX 23 AC5 VAL C 209 GLY C 218 1 10
HELIX 24 AC6 THR C 232 LYS C 238 1 7
HELIX 25 AC7 THR C 252 LYS C 257 5 6
HELIX 26 AC8 SER C 264 PHE C 269 1 6
HELIX 27 AC9 SER D 6 PHE D 11 1 6
HELIX 28 AD1 ILE D 16 LEU D 21 1 6
HELIX 29 AD2 GLU D 23 GLU D 28 1 6
HELIX 30 AD3 ARG D 65 GLY D 78 1 14
HELIX 31 AD4 ALA D 100 ARG D 106 1 7
HELIX 32 AD5 LYS D 108 GLY D 112 5 5
HELIX 33 AD6 ALA D 114 GLU D 128 1 15
HELIX 34 AD7 PRO E 15 MET E 19 5 5
HELIX 35 AD8 LYS E 37 CYS E 41 5 5
HELIX 36 AD9 PRO E 43 ASN E 50 1 8
HELIX 37 AE1 VAL E 61 MET E 66 1 6
HELIX 38 AE2 GLU E 117 TYR E 121 5 5
HELIX 39 AE3 THR E 247 SER E 262 1 16
HELIX 40 AE4 LYS F 18 LYS F 22 5 5
HELIX 41 AE5 VAL F 69 SER F 75 1 7
HELIX 42 AE6 MET F 76 ASN F 83 5 8
HELIX 43 AE7 VAL F 93 LEU F 102 1 10
HELIX 44 AE8 PRO F 108 ASN F 118 1 11
HELIX 45 AE9 ARG F 146 ILE F 151 1 6
HELIX 46 AF1 THR F 156 GLU F 160 5 5
HELIX 47 AF2 GLU F 171 ALA F 181 1 11
HELIX 48 AF3 SER F 187 SER F 202 1 16
HELIX 49 AF4 LYS G 23 TYR G 28 1 6
HELIX 50 AF5 ARG G 137 ARG G 142 1 6
HELIX 51 AF6 LEU G 212 ARG G 216 5 5
HELIX 52 AF7 MET G 217 LYS G 230 1 14
HELIX 53 AF8 GLU H 18 LEU H 30 1 13
HELIX 54 AF9 ALA H 38 LEU H 43 1 6
HELIX 55 AG1 PRO H 67 LEU H 69 5 3
HELIX 56 AG2 LYS H 70 ILE H 75 1 6
HELIX 57 AG3 ILE H 75 GLU H 82 1 8
HELIX 58 AG4 PRO H 117 ARG H 120 5 4
HELIX 59 AG5 THR H 121 ILE H 129 1 9
HELIX 60 AG6 GLU H 131 PHE H 135 5 5
HELIX 61 AG7 GLN H 162 GLU H 167 1 6
HELIX 62 AG8 HIS H 168 GLU H 171 5 4
HELIX 63 AG9 GLY H 175 THR H 181 1 7
HELIX 64 AH1 ARG I 49 GLY I 51 5 3
HELIX 65 AH2 ASN I 88 THR I 93 1 6
HELIX 66 AH3 SER I 106 ALA I 118 1 13
HELIX 67 AH4 THR I 130 GLU I 135 5 6
HELIX 68 AH5 LYS I 144 LYS I 153 1 10
HELIX 69 AH6 LYS I 154 ALA I 156 5 3
HELIX 70 AH7 SER I 159 GLU I 164 1 6
HELIX 71 AH8 GLU I 164 GLY I 169 1 6
HELIX 72 AH9 LYS I 193 ALA I 204 1 12
HELIX 73 AI1 LEU J 29 GLU J 34 1 6
HELIX 74 AI2 ASN J 39 TRP J 44 1 6
HELIX 75 AI3 ASP J 67 GLU J 73 1 7
HELIX 76 AI4 GLU J 73 LEU J 78 1 6
HELIX 77 AI5 LYS J 93 ILE J 97 5 5
HELIX 78 AI6 LEU J 110 PHE J 115 1 6
HELIX 79 AI7 SER J 122 GLN J 132 1 11
HELIX 80 AI8 ARG J 150 GLN J 154 5 5
HELIX 81 AI9 GLY J 171 LYS J 179 1 9
HELIX 82 AJ1 LYS K 6 LEU K 15 1 10
HELIX 83 AJ2 MET K 49 SER K 54 1 6
HELIX 84 AJ3 THR K 72 TYR K 78 1 7
HELIX 85 AJ4 LEU K 79 ASP K 81 5 3
HELIX 86 AJ5 VAL L 23 LYS L 30 1 8
HELIX 87 AJ6 ASP M 13 LEU M 18 1 6
HELIX 88 AJ7 GLU M 20 HIS M 28 1 9
HELIX 89 AJ8 ILE M 35 ALA M 41 1 7
HELIX 90 AJ9 GLU M 58 CYS M 69 1 12
HELIX 91 AK1 LYS M 83 TRP M 88 5 6
HELIX 92 AK2 GLN M 119 CYS M 130 1 12
HELIX 93 AK3 THR N 29 LYS N 39 1 11
HELIX 94 AK4 LYS N 39 GLY N 44 1 6
HELIX 95 AK5 THR N 46 SER N 57 1 12
HELIX 96 AK6 GLN N 62 GLY N 68 1 7
HELIX 97 AK7 LYS N 70 LYS N 76 1 7
HELIX 98 AK8 PRO N 85 LYS N 93 1 9
HELIX 99 AK9 LEU N 125 LYS N 130 1 6
HELIX 100 AL1 THR N 145 LEU N 149 5 5
HELIX 101 AL2 THR O 57 VAL O 62 1 6
HELIX 102 AL3 ALA O 64 GLU O 68 5 5
HELIX 103 AL4 TYR O 72 CYS O 85 1 14
HELIX 104 AL5 PRO O 110 LEU O 119 1 10
HELIX 105 AL6 ASP P 21 LEU P 26 1 6
HELIX 106 AL7 SER P 29 MET P 34 1 6
HELIX 107 AL8 SER P 38 ARG P 47 1 10
HELIX 108 AL9 SER P 55 LYS P 64 1 10
HELIX 109 AM1 LEU P 86 VAL P 90 5 5
HELIX 110 AM2 PRO Q 44 THR Q 46 5 3
HELIX 111 AM3 LEU Q 47 GLU Q 53 1 7
HELIX 112 AM4 GLY Q 76 TYR Q 82 1 7
HELIX 113 AM5 ARG Q 85 LYS Q 90 1 6
HELIX 114 AM6 LYS Q 90 TYR Q 99 1 10
HELIX 115 AM7 ASP Q 101 ASP Q 116 1 16
HELIX 116 AM8 ARG Q 117 LEU Q 120 5 4
HELIX 117 AM9 ARG R 14 LYS R 19 1 6
HELIX 118 AN1 HIS R 29 GLU R 37 1 9
HELIX 119 AN2 SER R 43 GLY R 64 1 22
HELIX 120 AN3 LEU R 73 ARG R 80 1 8
HELIX 121 AN4 ASP R 101 LEU R 108 1 8
HELIX 122 AN5 GLY S 37 LEU S 45 1 9
HELIX 123 AN6 THR S 60 MET S 71 1 12
HELIX 124 AN7 LEU S 99 GLU S 109 1 11
HELIX 125 AN8 GLU S 112 ILE S 117 1 6
HELIX 126 AN9 ARG S 121 PHE S 126 1 6
HELIX 127 AO1 THR T 5 VAL T 9 5 5
HELIX 128 AO2 ASN T 10 GLY T 26 1 17
HELIX 129 AO3 GLU T 32 THR T 36 5 5
HELIX 130 AO4 ASN T 51 TYR T 65 1 15
HELIX 131 AO5 GLY T 71 LYS T 77 1 7
HELIX 132 AO6 ALA T 100 GLU T 108 1 9
HELIX 133 AO7 GLN T 126 ALA T 139 1 14
HELIX 134 AO8 LYS U 30 GLY U 42 1 13
HELIX 135 AO9 SER U 95 SER U 105 1 11
HELIX 136 AP1 CYS V 56 ARG V 61 1 6
HELIX 137 AP2 SER V 65 ALA V 75 1 11
HELIX 138 AP3 ASN W 5 ALA W 10 1 6
HELIX 139 AP4 THR W 39 HIS W 44 1 6
HELIX 140 AP5 LYS W 88 LEU W 93 1 6
HELIX 141 AP6 GLU W 114 LYS W 119 1 6
HELIX 142 AP7 GLN X 26 HIS X 31 1 6
HELIX 143 AP8 THR Y 38 LYS Y 43 1 6
HELIX 144 AP9 LEU Y 44 LYS Y 49 1 6
HELIX 145 AQ1 THR Y 51 ILE Y 55 5 5
HELIX 146 AQ2 LEU Y 79 LYS Y 84 1 6
HELIX 147 AQ3 PRO Y 87 ARG Y 93 1 7
HELIX 148 AQ4 LYS Y 108 MET Y 114 1 7
HELIX 149 AQ5 THR Y 120 ASN Y 124 5 5
HELIX 150 AQ6 ASP Z 51 ASP Z 56 1 6
HELIX 151 AQ7 GLU Z 61 TYR Z 65 5 5
HELIX 152 AQ8 THR Z 69 SER Z 74 1 6
HELIX 153 AQ9 ARG Z 80 GLY Z 95 1 16
HELIX 154 AR1 SER b 11 LYS b 18 1 8
HELIX 155 AR2 ARG d 40 TYR d 46 1 7
HELIX 156 AR3 GLY e 10 THR e 16 1 7
HELIX 157 AR4 ALA e 32 PHE e 42 1 11
HELIX 158 AR5 ALA f 101 TYR f 105 1 5
HELIX 159 AR6 ARG x 84 GLU x 90 1 7
HELIX 160 AR7 ILE x 95 GLU x 101 1 7
HELIX 161 AR8 ASP x 126 ALA x 129 5 4
HELIX 162 AR9 LEU x 130 ASP x 135 1 6
HELIX 163 AS1 ASP x 135 PHE x 140 1 6
HELIX 164 AS2 GLN x 145 LEU x 150 1 6
HELIX 165 AS3 LEU x 150 LEU x 155 1 6
HELIX 166 AS4 ARG x 178 GLY x 185 1 8
HELIX 167 AS5 THR x 190 THR x 198 1 9
HELIX 168 AS6 SER x 214 MET x 220 1 7
HELIX 169 AS7 ARG x 222 LEU x 230 1 9
HELIX 170 AS8 SER x 235 ALA x 245 1 11
HELIX 171 AS9 ASP y 10 ARG y 16 1 7
HELIX 172 AT1 ARG y 31 GLU y 36 1 6
HELIX 173 AT2 ASP y 39 ARG y 44 1 6
HELIX 174 AT3 ARG y 44 LEU y 49 1 6
HELIX 175 AT4 PRO y 50 LEU y 53 5 4
HELIX 176 AT5 LEU y 59 THR y 67 1 9
HELIX 177 AT6 THR y 67 LYS y 72 1 6
HELIX 178 AT7 SER y 80 PHE y 97 1 18
HELIX 179 AT8 GLY y 99 LEU y 103 5 5
HELIX 180 AT9 ASN y 213 ILE y 217 5 5
HELIX 181 AU1 ASP y 238 LEU y 246 1 9
HELIX 182 AU2 PRO y 319 ARG y 323 5 5
HELIX 183 AU3 SER y 352 GLN y 357 1 6
HELIX 184 AU4 SER y 382 GLN y 386 5 5
HELIX 185 AU5 GLY y 393 LEU y 399 1 7
HELIX 186 AU6 LYS z 532 LYS z 547 1 16
HELIX 187 AU7 VAL z 554 GLU z 559 1 6
SHEET 1 AA1 2 ILE A 38 ARG A 41 0
SHEET 2 AA1 2 TYR A 47 ILE A 49 -1 O ILE A 48 N LYS A 40
SHEET 1 AA2 5 THR A 97 ILE A 99 0
SHEET 2 AA2 5 VAL A 74 ILE A 77 1 N VAL A 76 O ILE A 99
SHEET 3 AA2 5 LEU A 121 VAL A 124 1 O VAL A 123 N SER A 75
SHEET 4 AA2 5 THR A 144 CYS A 148 1 O ILE A 145 N VAL A 124
SHEET 5 AA2 5 ILE A 159 PRO A 162 1 O ILE A 161 N ALA A 146
SHEET 1 AA3 2 LYS B 28 LYS B 34 0
SHEET 2 AA3 2 ASN B 43 THR B 50 -1 O ILE B 44 N VAL B 33
SHEET 1 AA4 2 ARG B 82 PHE B 84 0
SHEET 2 AA4 2 MET B 103 LEU B 105 -1 O ASP B 104 N LYS B 83
SHEET 1 AA5 2 ASP B 90 VAL B 91 0
SHEET 2 AA5 2 CYS B 96 LEU B 97 -1 O LEU B 97 N ASP B 90
SHEET 1 AA6 3 MET B 120 VAL B 127 0
SHEET 2 AA6 3 LEU B 135 PHE B 142 -1 O LEU B 137 N VAL B 125
SHEET 3 AA6 3 LYS B 216 MET B 217 -1 O LYS B 216 N ARG B 136
SHEET 1 AA7 3 ASP C 104 LYS C 114 0
SHEET 2 AA7 3 ARG C 121 ILE C 130 -1 O PHE C 127 N LEU C 107
SHEET 3 AA7 3 LEU C 139 VAL C 141 -1 O GLY C 140 N VAL C 128
SHEET 1 AA8 2 HIS C 136 VAL C 137 0
SHEET 2 AA8 2 VAL C 163 PRO C 164 -1 O VAL C 163 N VAL C 137
SHEET 1 AA9 2 ILE C 204 VAL C 205 0
SHEET 2 AA9 2 CYS C 222 TYR C 223 1 O CYS C 222 N VAL C 205
SHEET 1 AB1 3 TYR D 34 VAL D 41 0
SHEET 2 AB1 3 THR D 46 ALA D 52 -1 O LEU D 51 N SER D 35
SHEET 3 AB1 3 VAL D 84 LYS D 90 1 O TYR D 87 N ILE D 50
SHEET 1 AB2 2 VAL D 138 SER D 139 0
SHEET 2 AB2 2 GLY D 183 ILE D 184 -1 O GLY D 183 N SER D 139
SHEET 1 AB3 2 SER D 209 ILE D 210 0
SHEET 2 AB3 2 ALA R 39 ILE R 40 -1 O ILE R 40 N SER D 209
SHEET 1 AB4 2 LEU E 9 LYS E 10 0
SHEET 2 AB4 2 PHE E 27 ALA E 28 -1 O ALA E 28 N LEU E 9
SHEET 1 AB5 2 LYS E 71 ILE E 72 0
SHEET 2 AB5 2 LYS E 75 VAL E 76 -1 O LYS E 75 N ILE E 72
SHEET 1 AB6 2 VAL E 126 GLY E 132 0
SHEET 2 AB6 2 ILE E 136 THR E 141 -1 O VAL E 140 N ARG E 127
SHEET 1 AB7 3 ILE E 195 ARG E 198 0
SHEET 2 AB7 3 VAL E 208 LYS E 211 -1 O HIS E 209 N THR E 196
SHEET 3 AB7 3 SER E 217 ALA E 219 -1 O PHE E 218 N VAL E 210
SHEET 1 AB8 2 GLU F 123 ASP F 124 0
SHEET 2 AB8 2 VAL F 139 ASP F 140 -1 O VAL F 139 N ASP F 124
SHEET 1 AB9 2 VAL G 49 ILE G 52 0
SHEET 2 AB9 2 LEU G 111 LYS G 115 -1 O VAL G 112 N ARG G 51
SHEET 1 AC1 2 ASN G 56 ASP G 57 0
SHEET 2 AC1 2 LEU G 106 VAL G 108 -1 O SER G 107 N ASN G 56
SHEET 1 AC2 2 VAL G 73 LEU G 76 0
SHEET 2 AC2 2 ARG G 94 VAL G 97 -1 O VAL G 97 N VAL G 73
SHEET 1 AC3 2 LYS G 160 LEU G 162 0
SHEET 2 AC3 2 ARG G 170 LYS G 172 -1 O LYS G 172 N LYS G 160
SHEET 1 AC4 3 ALA H 47 LYS H 49 0
SHEET 2 AC4 3 ILE H 60 PRO H 65 -1 O ILE H 61 N LYS H 49
SHEET 3 AC4 3 VAL H 92 GLN H 97 1 O GLN H 97 N VAL H 64
SHEET 1 AC5 2 ILE H 139 GLY H 141 0
SHEET 2 AC5 2 HIS H 157 LEU H 158 -1 O HIS H 157 N VAL H 140
SHEET 1 AC6 3 ARG H 145 VAL H 146 0
SHEET 2 AC6 3 ARG H 152 LYS H 155 -1 O LEU H 153 N ARG H 145
SHEET 3 AC6 3 VAL H 185 ASN H 186 1 O ASN H 186 N ILE H 154
SHEET 1 AC7 3 LYS I 37 ILE I 38 0
SHEET 2 AC7 3 LYS I 53 LEU I 60 1 O LEU I 58 N LYS I 37
SHEET 3 AC7 3 ARG I 42 ARG I 47 -1 N HIS I 44 O ARG I 56
SHEET 1 AC8 2 VAL I 62 ASN I 64 0
SHEET 2 AC8 2 LYS I 75 ARG I 77 -1 O THR I 76 N GLY I 63
SHEET 1 AC9 2 TYR I 83 ASN I 84 0
SHEET 2 AC9 2 CYS I 100 ILE I 101 -1 O ILE I 101 N TYR I 83
SHEET 1 AD1 2 ALA I 173 ILE I 175 0
SHEET 2 AD1 2 GLY I 187 VAL I 189 -1 O TYR I 188 N CYS I 174
SHEET 1 AD2 3 GLN J 140 VAL J 141 0
SHEET 2 AD2 3 ARG J 136 VAL J 137 -1 N VAL J 137 O GLN J 140
SHEET 3 AD2 3 ILE J 157 ASP J 158 -1 O ASP J 158 N ARG J 136
SHEET 1 AD3 2 VAL L 76 MET L 82 0
SHEET 2 AD3 2 THR L 85 ARG L 89 -1 O ARG L 89 N VAL L 76
SHEET 1 AD4 2 ASP L 91 TYR L 92 0
SHEET 2 AD4 2 ARG L 105 HIS L 106 -1 O ARG L 105 N TYR L 92
SHEET 1 AD5 2 VAL L 128 GLU L 130 0
SHEET 2 AD5 2 PHE L 140 VAL L 142 -1 O ASN L 141 N GLY L 129
SHEET 1 AD6 2 LEU M 31 ARG M 33 0
SHEET 2 AD6 2 VAL M 109 VAL M 111 -1 O VAL M 110 N ALA M 32
SHEET 1 AD7 2 LEU M 49 ALA M 53 0
SHEET 2 AD7 2 ASN M 75 VAL M 79 1 O ILE M 77 N LEU M 52
SHEET 1 AD8 2 LYS M 93 ILE M 94 0
SHEET 2 AD8 2 PRO M 100 LYS M 102 -1 O ARG M 101 N LYS M 93
SHEET 1 AD9 2 ALA O 92 LEU O 93 0
SHEET 2 AD9 2 LYS O 125 ILE O 126 1 O LYS O 125 N LEU O 93
SHEET 1 AE1 3 VAL P 76 THR P 78 0
SHEET 2 AE1 3 SER P 92 VAL P 96 1 O GLY P 95 N THR P 78
SHEET 3 AE1 3 VAL P 105 ILE P 107 -1 O ILE P 107 N SER P 92
SHEET 1 AE2 2 VAL Q 10 GLN Q 11 0
SHEET 2 AE2 2 HIS Q 24 CYS Q 25 -1 O CYS Q 25 N VAL Q 10
SHEET 1 AE3 2 THR Q 20 ALA Q 21 0
SHEET 2 AE3 2 VAL Q 72 LYS Q 73 -1 O LYS Q 73 N THR Q 20
SHEET 1 AE4 3 ARG Q 37 PRO Q 38 0
SHEET 2 AE4 3 ILE Q 32 VAL Q 34 -1 N VAL Q 34 O ARG Q 37
SHEET 3 AE4 3 ILE Q 68 ARG Q 69 1 O ILE Q 68 N LYS Q 33
SHEET 1 AE5 2 GLU R 97 VAL R 98 0
SHEET 2 AE5 2 GLN R 118 VAL R 119 1 O GLN R 118 N VAL R 98
SHEET 1 AE6 2 LEU S 13 VAL S 15 0
SHEET 2 AE6 2 THR S 18 ILE S 20 -1 O ILE S 20 N LEU S 13
SHEET 1 AE7 2 ARG T 82 GLN T 83 0
SHEET 2 AE7 2 HIS T 91 PHE T 92 -1 O HIS T 91 N GLN T 83
SHEET 1 AE8 2 VAL T 113 LYS T 115 0
SHEET 2 AE8 2 ARG T 121 LEU T 123 -1 O LYS T 122 N GLU T 114
SHEET 1 AE9 2 VAL U 54 THR U 60 0
SHEET 2 AE9 2 ARG U 83 LEU U 88 -1 O LYS U 86 N MET U 56
SHEET 1 AF1 2 ILE U 63 ARG U 66 0
SHEET 2 AF1 2 TRP U 77 PHE U 80 -1 O ASP U 78 N THR U 65
SHEET 1 AF2 2 GLN W 24 LEU W 26 0
SHEET 2 AF2 2 VAL W 62 ASN W 64 -1 O VAL W 63 N VAL W 25
SHEET 1 AF3 2 LEU W 104 THR W 106 0
SHEET 2 AF3 2 GLY W 109 MET W 111 -1 O GLY W 109 N THR W 106
SHEET 1 AF4 2 GLY X 49 VAL X 51 0
SHEET 2 AF4 2 VAL X 72 LEU X 74 -1 O GLN X 73 N ILE X 50
SHEET 1 AF5 2 GLY X 56 GLU X 58 0
SHEET 2 AF5 2 ILE X 66 LYS X 68 -1 O ARG X 67 N VAL X 57
SHEET 1 AF6 2 LYS X 124 VAL X 125 0
SHEET 2 AF6 2 VAL X 128 SER X 129 -1 O VAL X 128 N VAL X 125
SHEET 1 AF7 3 MET Y 23 ILE Y 25 0
SHEET 2 AF7 3 THR Y 69 GLY Y 73 -1 O GLY Y 71 N ILE Y 25
SHEET 3 AF7 3 PHE Y 58 THR Y 62 -1 N ARG Y 61 O THR Y 70
SHEET 1 AF8 2 LYS Z 98 SER Z 101 0
SHEET 2 AF8 2 ILE Z 108 THR Z 110 -1 O ILE Z 108 N SER Z 101
SHEET 1 AF9 2 CYS b 64 GLN b 65 0
SHEET 2 AF9 2 ARG b 72 LEU b 73 -1 O ARG b 72 N GLN b 65
SHEET 1 AG1 3 VAL c 17 THR c 21 0
SHEET 2 AG1 3 CYS c 27 VAL c 30 -1 O CYS c 27 N THR c 21
SHEET 3 AG1 3 ARG c 44 LYS c 47 -1 O VAL c 46 N THR c 28
SHEET 1 AG2 2 LEU d 30 ILE d 31 0
SHEET 2 AG2 2 MET d 38 CYS d 39 -1 O MET d 38 N ILE d 31
SHEET 1 AG3 2 TYR f 106 VAL f 108 0
SHEET 2 AG3 2 ILE f 114 ARG f 116 -1 O SER f 115 N LYS f 107
SHEET 1 AG4 3 ALA f 133 SER f 134 0
SHEET 2 AG4 3 HIS f 139 TYR f 140 -1 N TYR f 140 O ALA f 133
SHEET 3 AG4 3 THR f 147 TYR f 148 -1 O TYR f 148 N HIS f 139
SHEET 1 AG5 4 GLN g 4 LEU g 11 0
SHEET 2 AG5 4 VAL g 307 THR g 313 -1 O VAL g 307 N LEU g 11
SHEET 3 AG5 4 LEU g 298 TYR g 302 -1 N LEU g 298 O TRP g 310
SHEET 4 AG5 4 CYS g 286 LEU g 289 -1 N THR g 287 O GLY g 301
SHEET 1 AG6 4 VAL g 18 ALA g 22 0
SHEET 2 AG6 4 LEU g 32 SER g 35 -1 O ALA g 34 N THR g 19
SHEET 3 AG6 4 ILE g 40 LEU g 45 -1 O ILE g 41 N SER g 33
SHEET 4 AG6 4 GLY g 53 LEU g 59 -1 O LEU g 59 N ILE g 40
SHEET 1 AG7 2 VAL g 70 ILE g 71 0
SHEET 2 AG7 2 ALA g 78 LEU g 79 -1 O LEU g 79 N VAL g 70
SHEET 1 AG8 2 ARG g 88 ASP g 91 0
SHEET 2 AG8 2 THR g 96 ARG g 100 -1 O THR g 98 N LEU g 89
SHEET 1 AG9 2 VAL g 108 SER g 110 0
SHEET 2 AG9 2 GLY g 123 SER g 124 -1 O GLY g 123 N SER g 110
SHEET 1 AH1 2 ILE g 129 LYS g 130 0
SHEET 2 AH1 2 THR g 141 VAL g 142 -1 O VAL g 142 N ILE g 129
SHEET 1 AH2 2 VAL g 154 PHE g 156 0
SHEET 2 AH2 2 ILE g 165 SER g 167 -1 O VAL g 166 N ARG g 155
SHEET 1 AH3 2 LEU g 173 TRP g 177 0
SHEET 2 AH3 2 LEU g 184 ILE g 189 -1 O LYS g 185 N VAL g 176
SHEET 1 AH4 2 LEU g 206 CYS g 207 0
SHEET 2 AH4 2 TRP g 219 ASP g 220 -1 O TRP g 219 N CYS g 207
SHEET 1 AH5 3 ALA g 238 LEU g 239 0
SHEET 2 AH5 3 ALA g 250 ALA g 251 -1 O ALA g 251 N ALA g 238
SHEET 3 AH5 3 ILE g 256 LYS g 257 -1 O LYS g 257 N ALA g 250
SHEET 1 AH6 4 ILE x 78 PRO x 79 0
SHEET 2 AH6 4 ASN x 115 ARG x 119 -1 O VAL x 116 N ILE x 78
SHEET 3 AH6 4 GLN x 106 ASN x 110 -1 N ARG x 108 O GLU x 117
SHEET 4 AH6 4 PHE y 128 HIS y 129 1 O HIS y 129 N PHE x 109
SHEET 1 AH7 2 ILE x 202 LEU x 204 0
SHEET 2 AH7 2 VAL x 209 ILE x 211 -1 O HIS x 210 N VAL x 203
SHEET 1 AH8 2 VAL y 8 ALA y 9 0
SHEET 2 AH8 2 CYS y 234 LEU y 235 1 O LEU y 235 N VAL y 8
SHEET 1 AH9 2 TYR y 28 THR y 29 0
SHEET 2 AH9 2 ARG y 54 PHE y 55 1 O ARG y 54 N THR y 29
SHEET 1 AI1 2 ARG y 264 ARG y 269 0
SHEET 2 AI1 2 LYS y 294 THR y 299 -1 O VAL y 298 N SER y 265
LINK SG CYS d 21 ZN ZN d 201 1555 1555 2.23
LINK SG CYS d 24 ZN ZN d 201 1555 1555 2.50
LINK SG CYS d 39 ZN ZN d 201 1555 1555 2.36
LINK SG CYS d 42 ZN ZN d 201 1555 1555 2.51
LINK SG CYS f 121 ZN ZN f 201 1555 1555 2.05
LINK SG CYS f 141 ZN ZN f 201 1555 1555 2.02
LINK SG CYS f 144 ZN ZN f 201 1555 1555 2.32
LINK SG CYS y 270 ZN ZN y 500 1555 1555 2.84
LINK SG CYS y 273 ZN ZN y 500 1555 1555 2.53
LINK SG CYS y 285 ZN ZN y 500 1555 1555 2.84
LINK SG CYS y 288 ZN ZN y 500 1555 1555 2.49
CISPEP 1 ARG W 28 PRO W 29 0 -11.57
CISPEP 2 SER W 76 PRO W 77 0 1.89
SITE 1 AC1 4 CYS d 21 CYS d 24 CYS d 39 CYS d 42
SITE 1 AC2 4 CYS f 121 SER f 123 CYS f 141 CYS f 144
SITE 1 AC3 4 CYS y 270 CYS y 273 CYS y 285 CYS y 288
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
