HEADER NUCLEAR PROTEIN 26-APR-18 6GEJ
TITLE CHROMATIN REMODELLER-NUCLEOSOME COMPLEX AT 3.6 A RESOLUTION.
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72;
COMPND 3 CHAIN: Z;
COMPND 4 ENGINEERED: YES;
COMPND 5 MOL_ID: 2;
COMPND 6 MOLECULE: HISTONE H3;
COMPND 7 CHAIN: A, B;
COMPND 8 ENGINEERED: YES;
COMPND 9 MOL_ID: 3;
COMPND 10 MOLECULE: HISTONE H4;
COMPND 11 CHAIN: C, D;
COMPND 12 ENGINEERED: YES;
COMPND 13 MOL_ID: 4;
COMPND 14 MOLECULE: HISTONE H2A.1;
COMPND 15 CHAIN: E, F;
COMPND 16 ENGINEERED: YES;
COMPND 17 MOL_ID: 5;
COMPND 18 MOLECULE: HISTONE H2B.1;
COMPND 19 CHAIN: G, H;
COMPND 20 SYNONYM: SUPPRESSOR OF TY PROTEIN 12;
COMPND 21 ENGINEERED: YES;
COMPND 22 MOL_ID: 6;
COMPND 23 MOLECULE: DNA (154-MER);
COMPND 24 CHAIN: I;
COMPND 25 ENGINEERED: YES;
COMPND 26 MOL_ID: 7;
COMPND 27 MOLECULE: DNA (154-MER);
COMPND 28 CHAIN: J;
COMPND 29 ENGINEERED: YES;
COMPND 30 MOL_ID: 8;
COMPND 31 MOLECULE: HELICASE SWR1;
COMPND 32 CHAIN: M;
COMPND 33 SYNONYM: SWI2/SNF2-RELATED 1;
COMPND 34 EC: 3.6.4.12;
COMPND 35 ENGINEERED: YES;
COMPND 36 MOL_ID: 9;
COMPND 37 MOLECULE: ACTIN-LIKE PROTEIN ARP6;
COMPND 38 CHAIN: R;
COMPND 39 ENGINEERED: YES;
COMPND 40 MOL_ID: 10;
COMPND 41 MOLECULE: VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 71;
COMPND 42 CHAIN: S;
COMPND 43 SYNONYM: SWR COMPLEX PROTEIN 6;
COMPND 44 ENGINEERED: YES;
COMPND 45 MOL_ID: 11;
COMPND 46 MOLECULE: RUVB-LIKE PROTEIN 1;
COMPND 47 CHAIN: T, V, X;
COMPND 48 SYNONYM: RUVBL1,TIP49-HOMOLOGY PROTEIN 1,TIP49A HOMOLOG;
COMPND 49 EC: 3.6.4.12;
COMPND 50 ENGINEERED: YES;
COMPND 51 MOL_ID: 12;
COMPND 52 MOLECULE: RUVB-LIKE PROTEIN 2;
COMPND 53 CHAIN: U, W, Y;
COMPND 54 SYNONYM: RUVBL2,TIP49-HOMOLOGY PROTEIN 2,TIP49B HOMOLOG;
COMPND 55 EC: 3.6.4.12;
COMPND 56 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 3 S288C);
SOURCE 4 ORGANISM_TAXID: 559292;
SOURCE 5 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;
SOURCE 6 EXPRESSION_SYSTEM_TAXID: 7111;
SOURCE 7 MOL_ID: 2;
SOURCE 8 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 9 S288C);
SOURCE 10 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 11 ORGANISM_TAXID: 559292;
SOURCE 12 GENE: HHT1, YBR010W, YBR0201, HHT2, SIN2, YNL031C, N2749;
SOURCE 13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 14 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 15 MOL_ID: 3;
SOURCE 16 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 17 S288C);
SOURCE 18 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 19 ORGANISM_TAXID: 559292;
SOURCE 20 GENE: HHF1, YBR009C, YBR0122, HHF2, YNL030W, N2752;
SOURCE 21 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 22 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 23 MOL_ID: 4;
SOURCE 24 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 25 S288C);
SOURCE 26 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 27 ORGANISM_TAXID: 559292;
SOURCE 28 GENE: HTA1, H2A1, SPT11, YDR225W, YD9934.10;
SOURCE 29 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 30 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 31 MOL_ID: 5;
SOURCE 32 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 33 S288C);
SOURCE 34 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 35 ORGANISM_TAXID: 559292;
SOURCE 36 GENE: HTB1, H2B1, SPT12, YDR224C, YD9934.09C;
SOURCE 37 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 38 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 39 MOL_ID: 6;
SOURCE 40 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;
SOURCE 41 ORGANISM_TAXID: 32630;
SOURCE 42 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 43 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 44 MOL_ID: 7;
SOURCE 45 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;
SOURCE 46 ORGANISM_TAXID: 32630;
SOURCE 47 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 48 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 49 MOL_ID: 8;
SOURCE 50 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 51 S288C);
SOURCE 52 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 53 ORGANISM_TAXID: 559292;
SOURCE 54 GENE: SWR1, YDR334W, D9651.6;
SOURCE 55 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;
SOURCE 56 EXPRESSION_SYSTEM_TAXID: 7111;
SOURCE 57 MOL_ID: 9;
SOURCE 58 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 59 S288C);
SOURCE 60 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 61 ORGANISM_TAXID: 559292;
SOURCE 62 GENE: ARP6, YLR085C, L2393, L9449.13;
SOURCE 63 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;
SOURCE 64 EXPRESSION_SYSTEM_TAXID: 7111;
SOURCE 65 MOL_ID: 10;
SOURCE 66 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 67 S288C);
SOURCE 68 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 69 ORGANISM_TAXID: 559292;
SOURCE 70 GENE: VPS71, SWC6, YML041C, YM8054.02C;
SOURCE 71 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;
SOURCE 72 EXPRESSION_SYSTEM_TAXID: 7111;
SOURCE 73 MOL_ID: 11;
SOURCE 74 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 75 S288C);
SOURCE 76 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 77 ORGANISM_TAXID: 559292;
SOURCE 78 GENE: RVB1, TIH1, TIP49A, YDR190C;
SOURCE 79 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;
SOURCE 80 EXPRESSION_SYSTEM_TAXID: 7111;
SOURCE 81 MOL_ID: 12;
SOURCE 82 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 83 S288C);
SOURCE 84 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 85 ORGANISM_TAXID: 559292;
SOURCE 86 GENE: RVB2, TIH2, TIP49B, YPL235W, P1060;
SOURCE 87 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;
SOURCE 88 EXPRESSION_SYSTEM_TAXID: 7111
KEYWDS CHROMATIN, REMODELLER, ATPASE, HISTONE, NUCLEAR PROTEIN
EXPDTA ELECTRON MICROSCOPY
AUTHOR O.WILLHOFT,E.Y.D.CHUA,M.WILKINSON,D.B.WIGLEY
REVDAT 4 11-DEC-19 6GEJ 1 SCALE
REVDAT 3 23-JAN-19 6GEJ 1 REMARK LINK SITE
REVDAT 2 24-OCT-18 6GEJ 1 JRNL
REVDAT 1 17-OCT-18 6GEJ 0
JRNL AUTH O.WILLHOFT,M.GHONEIM,C.L.LIN,E.Y.D.CHUA,M.WILKINSON,
JRNL AUTH 2 Y.CHABAN,R.AYALA,E.A.MCCORMACK,L.OCLOO,D.S.RUEDA,D.B.WIGLEY
JRNL TITL STRUCTURE AND DYNAMICS OF THE YEAST SWR1-NUCLEOSOME COMPLEX.
JRNL REF SCIENCE V. 362 2018
JRNL REFN ESSN 1095-9203
JRNL PMID 30309918
JRNL DOI 10.1126/SCIENCE.AAT7716
REMARK 2
REMARK 2 RESOLUTION. 3.60 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : GCTF, CRYOSPARC, RELION, RELION, RELION
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.600
REMARK 3 NUMBER OF PARTICLES : 98529
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 6GEJ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 27-APR-18.
REMARK 100 THE DEPOSITION ID IS D_1200009835.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : SWR1-NUCLEOSOME COMPLEX;
REMARK 245 HISTONE; DNA; REMODELLER
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.03
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.00
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 5517
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : FEI FALCON III (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : NULL
REMARK 245 MAXIMUM DEFOCUS (NM) : NULL
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 1.72
REMARK 245 ILLUMINATION MODE : OTHER
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: EICOSAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: EICOSAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 139750 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 254510 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -955.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: Z, A, B, C, D, E, F, G, H, I,
REMARK 350 AND CHAINS: J, M, R, S, T, U, V, W, X, Y
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 0
REMARK 465 ALA A 1
REMARK 465 ARG A 2
REMARK 465 THR A 3
REMARK 465 LYS A 4
REMARK 465 GLN A 5
REMARK 465 THR A 6
REMARK 465 ALA A 7
REMARK 465 ARG A 8
REMARK 465 LYS A 9
REMARK 465 SER A 10
REMARK 465 THR A 11
REMARK 465 GLY A 12
REMARK 465 GLY A 13
REMARK 465 LYS A 14
REMARK 465 ALA A 15
REMARK 465 PRO A 16
REMARK 465 ARG A 17
REMARK 465 LYS A 18
REMARK 465 GLN A 19
REMARK 465 LEU A 20
REMARK 465 ALA A 21
REMARK 465 SER A 22
REMARK 465 LYS A 23
REMARK 465 ALA A 24
REMARK 465 ALA A 25
REMARK 465 ARG A 26
REMARK 465 LYS A 27
REMARK 465 SER A 28
REMARK 465 ALA A 29
REMARK 465 PRO A 30
REMARK 465 SER A 31
REMARK 465 THR A 32
REMARK 465 GLY A 33
REMARK 465 GLY A 34
REMARK 465 VAL A 35
REMARK 465 LYS A 36
REMARK 465 ARG A 134
REMARK 465 SER A 135
REMARK 465 MET B 0
REMARK 465 ALA B 1
REMARK 465 ARG B 2
REMARK 465 THR B 3
REMARK 465 LYS B 4
REMARK 465 GLN B 5
REMARK 465 THR B 6
REMARK 465 ALA B 7
REMARK 465 ARG B 8
REMARK 465 LYS B 9
REMARK 465 SER B 10
REMARK 465 THR B 11
REMARK 465 GLY B 12
REMARK 465 GLY B 13
REMARK 465 LYS B 14
REMARK 465 ALA B 15
REMARK 465 PRO B 16
REMARK 465 ARG B 17
REMARK 465 LYS B 18
REMARK 465 GLN B 19
REMARK 465 LEU B 20
REMARK 465 ALA B 21
REMARK 465 SER B 22
REMARK 465 LYS B 23
REMARK 465 ALA B 24
REMARK 465 ALA B 25
REMARK 465 ARG B 26
REMARK 465 LYS B 27
REMARK 465 SER B 28
REMARK 465 ALA B 29
REMARK 465 PRO B 30
REMARK 465 SER B 31
REMARK 465 THR B 32
REMARK 465 GLY B 33
REMARK 465 GLY B 34
REMARK 465 VAL B 35
REMARK 465 LYS B 36
REMARK 465 ARG B 134
REMARK 465 SER B 135
REMARK 465 MET C 0
REMARK 465 SER C 1
REMARK 465 GLY C 2
REMARK 465 ARG C 3
REMARK 465 GLY C 4
REMARK 465 LYS C 5
REMARK 465 GLY C 6
REMARK 465 GLY C 7
REMARK 465 LYS C 8
REMARK 465 GLY C 9
REMARK 465 LEU C 10
REMARK 465 GLY C 11
REMARK 465 LYS C 12
REMARK 465 GLY C 13
REMARK 465 GLY C 14
REMARK 465 ALA C 15
REMARK 465 LYS C 16
REMARK 465 ARG C 17
REMARK 465 HIS C 18
REMARK 465 ARG C 19
REMARK 465 LYS C 20
REMARK 465 MET D 0
REMARK 465 SER D 1
REMARK 465 GLY D 2
REMARK 465 ARG D 3
REMARK 465 GLY D 4
REMARK 465 LYS D 5
REMARK 465 GLY D 6
REMARK 465 GLY D 7
REMARK 465 LYS D 8
REMARK 465 GLY D 9
REMARK 465 LEU D 10
REMARK 465 GLY D 11
REMARK 465 LYS D 12
REMARK 465 GLY D 13
REMARK 465 GLY D 14
REMARK 465 ALA D 15
REMARK 465 LYS D 16
REMARK 465 ARG D 17
REMARK 465 HIS D 18
REMARK 465 ARG D 19
REMARK 465 LYS D 20
REMARK 465 ILE D 21
REMARK 465 LEU D 22
REMARK 465 MET E 0
REMARK 465 SER E 1
REMARK 465 GLY E 2
REMARK 465 GLY E 3
REMARK 465 LYS E 4
REMARK 465 GLY E 5
REMARK 465 GLY E 6
REMARK 465 LYS E 7
REMARK 465 ALA E 8
REMARK 465 GLY E 9
REMARK 465 SER E 10
REMARK 465 ALA E 11
REMARK 465 ALA E 12
REMARK 465 LYS E 13
REMARK 465 ALA E 14
REMARK 465 SER E 15
REMARK 465 LYS E 119
REMARK 465 LYS E 120
REMARK 465 SER E 121
REMARK 465 ALA E 122
REMARK 465 LYS E 123
REMARK 465 ALA E 124
REMARK 465 THR E 125
REMARK 465 LYS E 126
REMARK 465 ALA E 127
REMARK 465 SER E 128
REMARK 465 GLN E 129
REMARK 465 GLU E 130
REMARK 465 LEU E 131
REMARK 465 MET F 0
REMARK 465 SER F 1
REMARK 465 GLY F 2
REMARK 465 GLY F 3
REMARK 465 LYS F 4
REMARK 465 GLY F 5
REMARK 465 GLY F 6
REMARK 465 LYS F 7
REMARK 465 ALA F 8
REMARK 465 GLY F 9
REMARK 465 SER F 10
REMARK 465 ALA F 11
REMARK 465 ALA F 12
REMARK 465 LYS F 13
REMARK 465 ALA F 14
REMARK 465 SER F 15
REMARK 465 GLN F 16
REMARK 465 PRO F 118
REMARK 465 LYS F 119
REMARK 465 LYS F 120
REMARK 465 SER F 121
REMARK 465 ALA F 122
REMARK 465 LYS F 123
REMARK 465 ALA F 124
REMARK 465 THR F 125
REMARK 465 LYS F 126
REMARK 465 ALA F 127
REMARK 465 SER F 128
REMARK 465 GLN F 129
REMARK 465 GLU F 130
REMARK 465 LEU F 131
REMARK 465 MET G 0
REMARK 465 SER G 1
REMARK 465 ALA G 2
REMARK 465 LYS G 3
REMARK 465 ALA G 4
REMARK 465 GLU G 5
REMARK 465 LYS G 6
REMARK 465 LYS G 7
REMARK 465 PRO G 8
REMARK 465 ALA G 9
REMARK 465 SER G 10
REMARK 465 LYS G 11
REMARK 465 ALA G 12
REMARK 465 PRO G 13
REMARK 465 ALA G 14
REMARK 465 GLU G 15
REMARK 465 LYS G 16
REMARK 465 LYS G 17
REMARK 465 PRO G 18
REMARK 465 ALA G 19
REMARK 465 ALA G 20
REMARK 465 LYS G 21
REMARK 465 LYS G 22
REMARK 465 THR G 23
REMARK 465 SER G 24
REMARK 465 THR G 25
REMARK 465 SER G 26
REMARK 465 THR G 27
REMARK 465 ASP G 28
REMARK 465 GLY G 29
REMARK 465 LYS G 30
REMARK 465 LYS G 31
REMARK 465 ARG G 32
REMARK 465 GLN G 129
REMARK 465 ALA G 130
REMARK 465 MET H 0
REMARK 465 SER H 1
REMARK 465 ALA H 2
REMARK 465 LYS H 3
REMARK 465 ALA H 4
REMARK 465 GLU H 5
REMARK 465 LYS H 6
REMARK 465 LYS H 7
REMARK 465 PRO H 8
REMARK 465 ALA H 9
REMARK 465 SER H 10
REMARK 465 LYS H 11
REMARK 465 ALA H 12
REMARK 465 PRO H 13
REMARK 465 ALA H 14
REMARK 465 GLU H 15
REMARK 465 LYS H 16
REMARK 465 LYS H 17
REMARK 465 PRO H 18
REMARK 465 ALA H 19
REMARK 465 ALA H 20
REMARK 465 LYS H 21
REMARK 465 LYS H 22
REMARK 465 THR H 23
REMARK 465 SER H 24
REMARK 465 THR H 25
REMARK 465 SER H 26
REMARK 465 THR H 27
REMARK 465 ASP H 28
REMARK 465 GLY H 29
REMARK 465 LYS H 30
REMARK 465 LYS H 31
REMARK 465 ARG H 32
REMARK 465 SER H 33
REMARK 465 LYS H 34
REMARK 465 SER H 126
REMARK 465 SER H 127
REMARK 465 THR H 128
REMARK 465 GLN H 129
REMARK 465 ALA H 130
REMARK 465 MET M 1
REMARK 465 THR M 2
REMARK 465 THR M 3
REMARK 465 SER M 4
REMARK 465 ARG M 5
REMARK 465 LYS M 6
REMARK 465 SER M 7
REMARK 465 HIS M 8
REMARK 465 ALA M 9
REMARK 465 LYS M 10
REMARK 465 ASP M 11
REMARK 465 LYS M 12
REMARK 465 LYS M 13
REMARK 465 ALA M 14
REMARK 465 GLY M 15
REMARK 465 GLY M 16
REMARK 465 GLU M 17
REMARK 465 GLN M 18
REMARK 465 ASP M 19
REMARK 465 LEU M 20
REMARK 465 ALA M 21
REMARK 465 ASP M 22
REMARK 465 LEU M 23
REMARK 465 LYS M 24
REMARK 465 PHE M 25
REMARK 465 ARG M 26
REMARK 465 TYR M 27
REMARK 465 ASP M 28
REMARK 465 LEU M 29
REMARK 465 LEU M 30
REMARK 465 THR M 31
REMARK 465 ASN M 32
REMARK 465 GLU M 33
REMARK 465 LEU M 34
REMARK 465 PHE M 35
REMARK 465 HIS M 36
REMARK 465 LEU M 37
REMARK 465 ARG M 38
REMARK 465 GLU M 39
REMARK 465 PHE M 40
REMARK 465 VAL M 41
REMARK 465 SER M 42
REMARK 465 LEU M 43
REMARK 465 VAL M 44
REMARK 465 ASP M 45
REMARK 465 TYR M 46
REMARK 465 ASP M 47
REMARK 465 PRO M 48
REMARK 465 THR M 49
REMARK 465 HIS M 50
REMARK 465 PHE M 51
REMARK 465 ASN M 52
REMARK 465 ASP M 53
REMARK 465 SER M 54
REMARK 465 GLU M 55
REMARK 465 SER M 56
REMARK 465 PHE M 57
REMARK 465 GLN M 58
REMARK 465 LYS M 59
REMARK 465 PHE M 60
REMARK 465 LEU M 61
REMARK 465 ARG M 62
REMARK 465 GLU M 63
REMARK 465 THR M 64
REMARK 465 HIS M 65
REMARK 465 LEU M 66
REMARK 465 SER M 67
REMARK 465 LEU M 68
REMARK 465 GLU M 69
REMARK 465 GLU M 70
REMARK 465 ARG M 71
REMARK 465 GLY M 72
REMARK 465 GLU M 73
REMARK 465 LYS M 74
REMARK 465 PHE M 75
REMARK 465 THR M 76
REMARK 465 ASP M 77
REMARK 465 ASP M 78
REMARK 465 VAL M 79
REMARK 465 ALA M 80
REMARK 465 LYS M 81
REMARK 465 LYS M 82
REMARK 465 GLY M 83
REMARK 465 THR M 84
REMARK 465 ASN M 85
REMARK 465 GLY M 86
REMARK 465 ASP M 87
REMARK 465 LEU M 88
REMARK 465 THR M 89
REMARK 465 ARG M 90
REMARK 465 ARG M 91
REMARK 465 ARG M 92
REMARK 465 ARG M 93
REMARK 465 ASN M 94
REMARK 465 LEU M 95
REMARK 465 ARG M 96
REMARK 465 THR M 97
REMARK 465 SER M 98
REMARK 465 THR M 99
REMARK 465 VAL M 100
REMARK 465 VAL M 101
REMARK 465 SER M 102
REMARK 465 SER M 103
REMARK 465 GLU M 104
REMARK 465 THR M 105
REMARK 465 THR M 106
REMARK 465 ASN M 107
REMARK 465 GLU M 108
REMARK 465 LYS M 109
REMARK 465 LYS M 110
REMARK 465 GLY M 111
REMARK 465 ASP M 112
REMARK 465 ILE M 113
REMARK 465 GLU M 114
REMARK 465 LEU M 115
REMARK 465 LYS M 116
REMARK 465 LEU M 117
REMARK 465 GLU M 118
REMARK 465 SER M 119
REMARK 465 ILE M 120
REMARK 465 ALA M 121
REMARK 465 PRO M 122
REMARK 465 LEU M 123
REMARK 465 VAL M 124
REMARK 465 ARG M 125
REMARK 465 ASN M 126
REMARK 465 LYS M 127
REMARK 465 CYS M 128
REMARK 465 GLU M 129
REMARK 465 GLU M 130
REMARK 465 LEU M 131
REMARK 465 LYS M 132
REMARK 465 TYR M 133
REMARK 465 LYS M 134
REMARK 465 LEU M 135
REMARK 465 SER M 136
REMARK 465 ASP M 137
REMARK 465 HIS M 138
REMARK 465 SER M 139
REMARK 465 ASN M 140
REMARK 465 ARG M 141
REMARK 465 LYS M 142
REMARK 465 SER M 143
REMARK 465 ILE M 144
REMARK 465 VAL M 145
REMARK 465 PRO M 146
REMARK 465 GLN M 147
REMARK 465 LYS M 148
REMARK 465 ARG M 149
REMARK 465 PRO M 150
REMARK 465 ILE M 151
REMARK 465 GLN M 152
REMARK 465 HIS M 153
REMARK 465 LEU M 154
REMARK 465 LYS M 155
REMARK 465 LYS M 156
REMARK 465 ARG M 157
REMARK 465 GLU M 158
REMARK 465 ALA M 159
REMARK 465 ALA M 160
REMARK 465 LYS M 161
REMARK 465 SER M 162
REMARK 465 LEU M 163
REMARK 465 LYS M 164
REMARK 465 PHE M 165
REMARK 465 LYS M 166
REMARK 465 SER M 167
REMARK 465 GLU M 168
REMARK 465 ARG M 169
REMARK 465 LYS M 170
REMARK 465 GLU M 171
REMARK 465 ASN M 172
REMARK 465 PRO M 173
REMARK 465 LEU M 174
REMARK 465 PRO M 175
REMARK 465 LEU M 176
REMARK 465 HIS M 177
REMARK 465 GLU M 178
REMARK 465 HIS M 179
REMARK 465 ILE M 180
REMARK 465 ALA M 181
REMARK 465 GLU M 182
REMARK 465 GLU M 183
REMARK 465 ARG M 184
REMARK 465 TYR M 185
REMARK 465 ASP M 186
REMARK 465 HIS M 187
REMARK 465 ILE M 188
REMARK 465 ALA M 189
REMARK 465 LYS M 190
REMARK 465 VAL M 191
REMARK 465 GLU M 192
REMARK 465 GLU M 193
REMARK 465 PRO M 194
REMARK 465 SER M 195
REMARK 465 GLU M 196
REMARK 465 ALA M 197
REMARK 465 PHE M 198
REMARK 465 THR M 199
REMARK 465 ILE M 200
REMARK 465 LYS M 201
REMARK 465 CYS M 202
REMARK 465 PRO M 203
REMARK 465 SER M 204
REMARK 465 ASP M 205
REMARK 465 ASP M 206
REMARK 465 SER M 207
REMARK 465 SER M 208
REMARK 465 PHE M 209
REMARK 465 GLU M 210
REMARK 465 ASN M 211
REMARK 465 THR M 212
REMARK 465 SER M 213
REMARK 465 GLU M 214
REMARK 465 HIS M 215
REMARK 465 TYR M 216
REMARK 465 SER M 217
REMARK 465 ASP M 218
REMARK 465 ASN M 219
REMARK 465 PHE M 220
REMARK 465 TYR M 221
REMARK 465 PHE M 222
REMARK 465 THR M 223
REMARK 465 THR M 224
REMARK 465 SER M 225
REMARK 465 SER M 226
REMARK 465 GLU M 227
REMARK 465 GLU M 228
REMARK 465 GLU M 229
REMARK 465 ASP M 230
REMARK 465 ILE M 231
REMARK 465 LYS M 232
REMARK 465 LYS M 233
REMARK 465 LYS M 234
REMARK 465 ARG M 235
REMARK 465 GLY M 236
REMARK 465 ARG M 237
REMARK 465 LYS M 238
REMARK 465 LYS M 239
REMARK 465 LYS M 240
REMARK 465 LYS M 241
REMARK 465 PRO M 242
REMARK 465 ARG M 243
REMARK 465 ILE M 244
REMARK 465 LYS M 245
REMARK 465 LEU M 246
REMARK 465 VAL M 247
REMARK 465 VAL M 248
REMARK 465 HIS M 249
REMARK 465 PRO M 250
REMARK 465 PRO M 251
REMARK 465 LYS M 252
REMARK 465 GLN M 253
REMARK 465 THR M 254
REMARK 465 ILE M 255
REMARK 465 THR M 256
REMARK 465 ASN M 257
REMARK 465 PRO M 258
REMARK 465 LEU M 259
REMARK 465 HIS M 260
REMARK 465 VAL M 261
REMARK 465 VAL M 262
REMARK 465 LYS M 263
REMARK 465 PRO M 264
REMARK 465 GLY M 265
REMARK 465 TYR M 266
REMARK 465 GLU M 267
REMARK 465 SER M 268
REMARK 465 LEU M 269
REMARK 465 HIS M 270
REMARK 465 GLU M 271
REMARK 465 TYR M 272
REMARK 465 ILE M 273
REMARK 465 ALA M 274
REMARK 465 SER M 275
REMARK 465 PHE M 276
REMARK 465 LYS M 277
REMARK 465 SER M 278
REMARK 465 LEU M 279
REMARK 465 GLU M 280
REMARK 465 ASP M 281
REMARK 465 ASP M 282
REMARK 465 LEU M 283
REMARK 465 THR M 284
REMARK 465 LEU M 285
REMARK 465 GLU M 286
REMARK 465 GLU M 287
REMARK 465 TYR M 288
REMARK 465 ASN M 289
REMARK 465 LYS M 290
REMARK 465 TYR M 291
REMARK 465 ILE M 292
REMARK 465 ASP M 293
REMARK 465 GLU M 294
REMARK 465 GLN M 295
REMARK 465 ARG M 296
REMARK 465 ARG M 297
REMARK 465 LEU M 298
REMARK 465 LEU M 299
REMARK 465 SER M 300
REMARK 465 ARG M 301
REMARK 465 LEU M 302
REMARK 465 LYS M 303
REMARK 465 LYS M 304
REMARK 465 GLY M 305
REMARK 465 ILE M 306
REMARK 465 GLU M 307
REMARK 465 ASN M 308
REMARK 465 GLY M 309
REMARK 465 ALA M 310
REMARK 465 LEU M 311
REMARK 465 LYS M 312
REMARK 465 TYR M 313
REMARK 465 ASP M 314
REMARK 465 LYS M 315
REMARK 465 GLU M 316
REMARK 465 THR M 317
REMARK 465 ASP M 318
REMARK 465 SER M 319
REMARK 465 LEU M 320
REMARK 465 GLN M 321
REMARK 465 PRO M 322
REMARK 465 ILE M 323
REMARK 465 THR M 324
REMARK 465 SER M 325
REMARK 465 LYS M 326
REMARK 465 GLU M 327
REMARK 465 ILE M 328
REMARK 465 LYS M 329
REMARK 465 THR M 330
REMARK 465 ILE M 331
REMARK 465 ILE M 332
REMARK 465 THR M 333
REMARK 465 TYR M 334
REMARK 465 LYS M 335
REMARK 465 PRO M 336
REMARK 465 ASP M 337
REMARK 465 PRO M 338
REMARK 465 ILE M 339
REMARK 465 SER M 340
REMARK 465 TYR M 341
REMARK 465 PHE M 342
REMARK 465 TYR M 343
REMARK 465 LYS M 344
REMARK 465 GLN M 345
REMARK 465 GLN M 346
REMARK 465 ASP M 347
REMARK 465 LEU M 348
REMARK 465 GLN M 349
REMARK 465 ILE M 350
REMARK 465 HIS M 351
REMARK 465 THR M 352
REMARK 465 ASP M 353
REMARK 465 HIS M 354
REMARK 465 LEU M 355
REMARK 465 ILE M 356
REMARK 465 ASN M 357
REMARK 465 GLN M 358
REMARK 465 GLY M 359
REMARK 465 ILE M 360
REMARK 465 HIS M 361
REMARK 465 MET M 362
REMARK 465 SER M 363
REMARK 465 LYS M 364
REMARK 465 LEU M 365
REMARK 465 PHE M 366
REMARK 465 ARG M 367
REMARK 465 SER M 368
REMARK 465 SER M 369
REMARK 465 THR M 370
REMARK 465 LYS M 371
REMARK 465 ALA M 372
REMARK 465 ARG M 373
REMARK 465 ILE M 374
REMARK 465 ALA M 375
REMARK 465 ARG M 376
REMARK 465 ALA M 377
REMARK 465 LYS M 378
REMARK 465 LYS M 379
REMARK 465 VAL M 380
REMARK 465 SER M 381
REMARK 465 GLN M 382
REMARK 465 MET M 383
REMARK 465 ILE M 384
REMARK 465 GLU M 385
REMARK 465 GLN M 386
REMARK 465 HIS M 387
REMARK 465 PHE M 388
REMARK 465 LYS M 389
REMARK 465 HIS M 390
REMARK 465 VAL M 391
REMARK 465 ALA M 392
REMARK 465 GLY M 393
REMARK 465 ALA M 394
REMARK 465 GLU M 395
REMARK 465 GLU M 396
REMARK 465 ARG M 397
REMARK 465 LYS M 398
REMARK 465 ALA M 399
REMARK 465 LYS M 400
REMARK 465 GLU M 401
REMARK 465 GLU M 402
REMARK 465 GLU M 403
REMARK 465 ARG M 404
REMARK 465 HIS M 405
REMARK 465 LYS M 406
REMARK 465 LYS M 407
REMARK 465 SER M 408
REMARK 465 LEU M 409
REMARK 465 ALA M 410
REMARK 465 ARG M 411
REMARK 465 PHE M 412
REMARK 465 ALA M 413
REMARK 465 VAL M 414
REMARK 465 GLN M 415
REMARK 465 ALA M 416
REMARK 465 VAL M 417
REMARK 465 LYS M 418
REMARK 465 LYS M 419
REMARK 465 ARG M 420
REMARK 465 TRP M 421
REMARK 465 ASN M 422
REMARK 465 MET M 423
REMARK 465 ALA M 424
REMARK 465 GLU M 425
REMARK 465 LYS M 426
REMARK 465 ALA M 427
REMARK 465 TYR M 428
REMARK 465 ARG M 429
REMARK 465 ILE M 430
REMARK 465 LEU M 431
REMARK 465 ARG M 432
REMARK 465 LYS M 433
REMARK 465 ASP M 434
REMARK 465 GLU M 435
REMARK 465 GLU M 436
REMARK 465 GLU M 437
REMARK 465 GLN M 438
REMARK 465 LEU M 439
REMARK 465 LYS M 440
REMARK 465 ARG M 441
REMARK 465 ILE M 442
REMARK 465 GLU M 443
REMARK 465 GLY M 444
REMARK 465 LYS M 445
REMARK 465 GLN M 446
REMARK 465 HIS M 447
REMARK 465 LEU M 448
REMARK 465 SER M 449
REMARK 465 LYS M 450
REMARK 465 MET M 451
REMARK 465 LEU M 452
REMARK 465 GLU M 453
REMARK 465 LYS M 454
REMARK 465 SER M 455
REMARK 465 THR M 456
REMARK 465 GLN M 457
REMARK 465 LEU M 458
REMARK 465 LEU M 459
REMARK 465 GLU M 460
REMARK 465 ALA M 461
REMARK 465 GLN M 462
REMARK 465 LEU M 463
REMARK 465 ASN M 464
REMARK 465 GLN M 465
REMARK 465 VAL M 466
REMARK 465 ASN M 467
REMARK 465 ASP M 468
REMARK 465 ASP M 469
REMARK 465 GLY M 470
REMARK 465 ARG M 471
REMARK 465 SER M 472
REMARK 465 SER M 473
REMARK 465 THR M 474
REMARK 465 PRO M 475
REMARK 465 SER M 476
REMARK 465 SER M 477
REMARK 465 ASP M 478
REMARK 465 SER M 479
REMARK 465 ASN M 480
REMARK 465 ASP M 481
REMARK 465 VAL M 482
REMARK 465 LEU M 483
REMARK 465 SER M 484
REMARK 465 GLU M 485
REMARK 465 SER M 486
REMARK 465 ASP M 487
REMARK 465 ASP M 488
REMARK 465 ASP M 489
REMARK 465 MET M 490
REMARK 465 ASP M 491
REMARK 465 ASP M 492
REMARK 465 GLU M 493
REMARK 465 LEU M 494
REMARK 465 SER M 495
REMARK 465 THR M 496
REMARK 465 SER M 497
REMARK 465 SER M 498
REMARK 465 ASP M 499
REMARK 465 GLU M 500
REMARK 465 ASP M 501
REMARK 465 GLU M 502
REMARK 465 GLU M 503
REMARK 465 VAL M 504
REMARK 465 ASP M 505
REMARK 465 ALA M 506
REMARK 465 ASP M 507
REMARK 465 VAL M 508
REMARK 465 GLY M 509
REMARK 465 LEU M 510
REMARK 465 GLU M 511
REMARK 465 ASN M 512
REMARK 465 SER M 513
REMARK 465 PRO M 514
REMARK 465 ALA M 515
REMARK 465 SER M 516
REMARK 465 THR M 517
REMARK 465 GLU M 518
REMARK 465 ALA M 519
REMARK 465 THR M 520
REMARK 465 PRO M 521
REMARK 465 THR M 522
REMARK 465 ASP M 523
REMARK 465 GLU M 524
REMARK 465 SER M 525
REMARK 465 LEU M 526
REMARK 465 ASN M 527
REMARK 465 LEU M 528
REMARK 465 ILE M 529
REMARK 465 GLN M 530
REMARK 465 LEU M 531
REMARK 465 LYS M 532
REMARK 465 GLU M 533
REMARK 465 LYS M 534
REMARK 465 TYR M 535
REMARK 465 GLY M 536
REMARK 465 HIS M 537
REMARK 465 PHE M 538
REMARK 465 ASN M 539
REMARK 465 GLY M 540
REMARK 465 SER M 541
REMARK 465 SER M 542
REMARK 465 THR M 543
REMARK 465 VAL M 544
REMARK 465 TYR M 545
REMARK 465 ASP M 546
REMARK 465 SER M 547
REMARK 465 ARG M 548
REMARK 465 ASN M 549
REMARK 465 LYS M 550
REMARK 465 ASP M 551
REMARK 465 GLU M 552
REMARK 465 LYS M 553
REMARK 465 PHE M 554
REMARK 465 PRO M 555
REMARK 465 THR M 556
REMARK 465 LEU M 557
REMARK 465 ASP M 558
REMARK 465 LYS M 559
REMARK 465 HIS M 560
REMARK 465 GLU M 561
REMARK 465 SER M 562
REMARK 465 SER M 563
REMARK 465 SER M 564
REMARK 465 SER M 565
REMARK 465 GLU M 566
REMARK 465 SER M 567
REMARK 465 SER M 568
REMARK 465 VAL M 569
REMARK 465 MET M 570
REMARK 465 THR M 571
REMARK 465 GLY M 572
REMARK 465 GLU M 573
REMARK 465 GLU M 574
REMARK 465 SER M 575
REMARK 465 SER M 576
REMARK 465 ILE M 577
REMARK 465 TYR M 578
REMARK 465 SER M 579
REMARK 465 SER M 580
REMARK 465 SER M 581
REMARK 465 GLU M 582
REMARK 465 ASN M 583
REMARK 465 GLU M 584
REMARK 465 SER M 585
REMARK 465 GLN M 586
REMARK 465 ASN M 587
REMARK 465 GLU M 588
REMARK 465 ASN M 589
REMARK 465 ASP M 590
REMARK 465 ARG M 591
REMARK 465 GLU M 592
REMARK 465 SER M 593
REMARK 465 ASP M 594
REMARK 465 ASP M 595
REMARK 465 LYS M 596
REMARK 465 THR M 597
REMARK 465 PRO M 598
REMARK 465 SER M 599
REMARK 465 VAL M 600
REMARK 465 GLY M 601
REMARK 465 LEU M 602
REMARK 465 SER M 603
REMARK 465 ALA M 604
REMARK 465 LEU M 605
REMARK 465 PHE M 606
REMARK 465 GLY M 607
REMARK 465 LYS M 608
REMARK 465 GLY M 609
REMARK 465 GLU M 610
REMARK 465 GLU M 611
REMARK 465 SER M 612
REMARK 465 ASP M 613
REMARK 465 GLY M 614
REMARK 465 ASP M 615
REMARK 465 LEU M 616
REMARK 465 ASP M 617
REMARK 465 LEU M 618
REMARK 465 ASP M 619
REMARK 465 ASP M 620
REMARK 465 SER M 621
REMARK 465 GLU M 622
REMARK 465 ASP M 623
REMARK 465 PHE M 624
REMARK 465 THR M 625
REMARK 465 VAL M 626
REMARK 465 ASN M 627
REMARK 465 SER M 628
REMARK 465 SER M 629
REMARK 465 SER M 630
REMARK 465 VAL M 631
REMARK 465 GLU M 632
REMARK 465 GLY M 633
REMARK 465 GLU M 634
REMARK 465 GLU M 635
REMARK 465 LEU M 636
REMARK 465 GLU M 637
REMARK 465 LYS M 638
REMARK 465 ASP M 639
REMARK 465 GLN M 640
REMARK 465 VAL M 641
REMARK 465 ASP M 642
REMARK 465 ASN M 643
REMARK 465 SER M 644
REMARK 465 ALA M 645
REMARK 465 ALA M 646
REMARK 465 THR M 647
REMARK 465 PHE M 648
REMARK 465 GLU M 649
REMARK 465 ARG M 650
REMARK 465 ALA M 651
REMARK 465 GLY M 652
REMARK 465 ASP M 653
REMARK 465 PHE M 654
REMARK 465 VAL M 655
REMARK 465 HIS M 656
REMARK 465 THR M 657
REMARK 465 GLN M 658
REMARK 465 ASN M 659
REMARK 465 GLU M 660
REMARK 465 ASN M 661
REMARK 465 ARG M 662
REMARK 465 ASP M 663
REMARK 465 ASP M 664
REMARK 465 ILE M 665
REMARK 465 LYS M 666
REMARK 465 ASP M 667
REMARK 465 VAL M 668
REMARK 465 GLU M 669
REMARK 465 GLU M 670
REMARK 465 ASP M 671
REMARK 465 ALA M 672
REMARK 465 GLU M 673
REMARK 465 THR M 674
REMARK 465 LYS M 675
REMARK 465 VAL M 676
REMARK 465 GLN M 677
REMARK 465 GLU M 678
REMARK 465 GLU M 679
REMARK 465 GLN M 680
REMARK 465 LEU M 681
REMARK 465 ASP M 886
REMARK 465 LEU M 887
REMARK 465 ASP M 888
REMARK 465 ALA M 889
REMARK 465 PHE M 890
REMARK 465 GLN M 891
REMARK 465 GLN M 892
REMARK 465 TRP M 893
REMARK 465 PHE M 894
REMARK 465 GLY M 895
REMARK 465 ARG M 896
REMARK 465 PRO M 897
REMARK 465 VAL M 898
REMARK 465 ASP M 899
REMARK 465 LYS M 900
REMARK 465 ILE M 901
REMARK 465 ILE M 902
REMARK 465 GLU M 903
REMARK 465 THR M 904
REMARK 465 GLY M 905
REMARK 465 GLN M 906
REMARK 465 ASN M 907
REMARK 465 PHE M 908
REMARK 465 GLY M 909
REMARK 465 GLN M 910
REMARK 465 ASP M 911
REMARK 465 LYS M 912
REMARK 465 GLY M 1397
REMARK 465 ASP M 1398
REMARK 465 PHE M 1399
REMARK 465 THR M 1400
REMARK 465 THR M 1401
REMARK 465 ASP M 1402
REMARK 465 TYR M 1403
REMARK 465 PHE M 1404
REMARK 465 SER M 1405
REMARK 465 LYS M 1406
REMARK 465 LEU M 1407
REMARK 465 SER M 1408
REMARK 465 VAL M 1409
REMARK 465 ARG M 1410
REMARK 465 ASP M 1411
REMARK 465 LEU M 1412
REMARK 465 LEU M 1413
REMARK 465 GLY M 1414
REMARK 465 SER M 1415
REMARK 465 GLU M 1416
REMARK 465 LEU M 1417
REMARK 465 PRO M 1418
REMARK 465 GLU M 1419
REMARK 465 ASN M 1420
REMARK 465 ALA M 1421
REMARK 465 SER M 1422
REMARK 465 GLY M 1423
REMARK 465 GLY M 1424
REMARK 465 ASP M 1425
REMARK 465 LYS M 1426
REMARK 465 PRO M 1427
REMARK 465 LEU M 1428
REMARK 465 ILE M 1429
REMARK 465 ALA M 1430
REMARK 465 ASP M 1431
REMARK 465 ALA M 1432
REMARK 465 ASP M 1433
REMARK 465 VAL M 1434
REMARK 465 ALA M 1435
REMARK 465 ALA M 1436
REMARK 465 LYS M 1437
REMARK 465 ASP M 1438
REMARK 465 PRO M 1439
REMARK 465 ARG M 1440
REMARK 465 GLN M 1441
REMARK 465 LEU M 1442
REMARK 465 GLU M 1443
REMARK 465 ARG M 1444
REMARK 465 LEU M 1445
REMARK 465 LEU M 1446
REMARK 465 ALA M 1447
REMARK 465 GLN M 1448
REMARK 465 ALA M 1449
REMARK 465 GLU M 1450
REMARK 465 ASP M 1451
REMARK 465 GLU M 1452
REMARK 465 ASP M 1453
REMARK 465 ASP M 1454
REMARK 465 VAL M 1455
REMARK 465 LYS M 1456
REMARK 465 ALA M 1457
REMARK 465 ALA M 1458
REMARK 465 ASN M 1459
REMARK 465 LEU M 1460
REMARK 465 ALA M 1461
REMARK 465 MET M 1462
REMARK 465 ARG M 1463
REMARK 465 GLU M 1464
REMARK 465 VAL M 1465
REMARK 465 GLU M 1466
REMARK 465 ILE M 1467
REMARK 465 ASP M 1468
REMARK 465 ASN M 1469
REMARK 465 ASP M 1470
REMARK 465 ASP M 1471
REMARK 465 PHE M 1472
REMARK 465 ASP M 1473
REMARK 465 GLU M 1474
REMARK 465 SER M 1475
REMARK 465 THR M 1476
REMARK 465 GLU M 1477
REMARK 465 LYS M 1478
REMARK 465 LYS M 1479
REMARK 465 ALA M 1480
REMARK 465 ALA M 1481
REMARK 465 ASN M 1482
REMARK 465 GLU M 1483
REMARK 465 GLU M 1484
REMARK 465 GLU M 1485
REMARK 465 GLU M 1486
REMARK 465 ASN M 1487
REMARK 465 HIS M 1488
REMARK 465 ALA M 1489
REMARK 465 GLU M 1490
REMARK 465 LEU M 1491
REMARK 465 ASP M 1492
REMARK 465 GLU M 1493
REMARK 465 TYR M 1494
REMARK 465 GLU M 1495
REMARK 465 GLY M 1496
REMARK 465 THR M 1497
REMARK 465 ALA M 1498
REMARK 465 HIS M 1499
REMARK 465 VAL M 1500
REMARK 465 ASP M 1501
REMARK 465 GLU M 1502
REMARK 465 TYR M 1503
REMARK 465 MET M 1504
REMARK 465 ILE M 1505
REMARK 465 ARG M 1506
REMARK 465 PHE M 1507
REMARK 465 ILE M 1508
REMARK 465 ALA M 1509
REMARK 465 ASN M 1510
REMARK 465 GLY M 1511
REMARK 465 TYR M 1512
REMARK 465 TYR M 1513
REMARK 465 TYR M 1514
REMARK 465 MET R 1
REMARK 465 ASP R 156
REMARK 465 ILE R 157
REMARK 465 ASP R 158
REMARK 465 ILE R 159
REMARK 465 VAL R 160
REMARK 465 ARG R 161
REMARK 465 GLY R 162
REMARK 465 ASN R 163
REMARK 465 SER R 164
REMARK 465 ASP R 165
REMARK 465 SER R 166
REMARK 465 THR R 167
REMARK 465 ASN R 168
REMARK 465 SER R 169
REMARK 465 THR R 170
REMARK 465 SER R 171
REMARK 465 SER R 172
REMARK 465 GLU R 173
REMARK 465 SER R 174
REMARK 465 LYS R 175
REMARK 465 ASN R 176
REMARK 465 ALA R 177
REMARK 465 GLN R 178
REMARK 465 ASP R 179
REMARK 465 SER R 180
REMARK 465 GLY R 181
REMARK 465 ASP S 23
REMARK 465 PRO S 24
REMARK 465 GLN S 25
REMARK 465 ALA S 26
REMARK 465 ARG S 27
REMARK 465 ARG S 28
REMARK 465 TYR S 29
REMARK 465 THR S 30
REMARK 465 SER S 31
REMARK 465 LYS S 32
REMARK 465 LYS S 33
REMARK 465 ILE S 34
REMARK 465 ASN S 35
REMARK 465 LYS S 36
REMARK 465 GLN S 37
REMARK 465 GLY S 38
REMARK 465 THR S 39
REMARK 465 ILE S 40
REMARK 465 SER S 41
REMARK 465 THR S 42
REMARK 465 SER S 63
REMARK 465 ARG S 64
REMARK 465 SER S 65
REMARK 465 GLU S 66
REMARK 465 GLY S 67
REMARK 465 ASP S 68
REMARK 465 GLY S 69
REMARK 465 ASN S 70
REMARK 465 SER S 71
REMARK 465 ILE S 72
REMARK 465 SER S 73
REMARK 465 ARG S 74
REMARK 465 GLN S 75
REMARK 465 ASP S 76
REMARK 465 ASP S 77
REMARK 465 ARG S 78
REMARK 465 ASN S 79
REMARK 465 SER S 80
REMARK 465 LYS S 81
REMARK 465 ASN S 82
REMARK 465 SER S 83
REMARK 465 HIS S 84
REMARK 465 SER S 85
REMARK 465 PHE S 86
REMARK 465 GLU S 87
REMARK 465 GLU S 88
REMARK 465 SER S 139
REMARK 465 GLN S 140
REMARK 465 THR S 141
REMARK 465 SER S 142
REMARK 465 ASP S 143
REMARK 465 GLY S 144
REMARK 465 LEU S 145
REMARK 465 SER S 146
REMARK 465 ALA S 147
REMARK 465 LEU S 148
REMARK 465 MET S 149
REMARK 465 GLY S 150
REMARK 465 GLY S 151
REMARK 465 SER S 152
REMARK 465 SER S 153
REMARK 465 PHE S 154
REMARK 465 VAL S 155
REMARK 465 LYS S 156
REMARK 465 GLU S 157
REMARK 465 HIS S 158
REMARK 465 SER S 159
REMARK 465 LYS S 160
REMARK 465 TYR S 161
REMARK 465 GLY S 162
REMARK 465 HIS S 163
REMARK 465 GLY S 164
REMARK 465 MET T 1
REMARK 465 VAL T 2
REMARK 465 ALA T 3
REMARK 465 ILE T 4
REMARK 465 SER T 5
REMARK 465 GLU T 6
REMARK 465 VAL T 7
REMARK 465 LYS T 8
REMARK 465 GLU T 9
REMARK 465 ASN T 10
REMARK 465 PRO T 11
REMARK 465 GLY T 12
REMARK 465 VAL T 13
REMARK 465 ASN T 14
REMARK 465 SER T 15
REMARK 465 SER T 16
REMARK 465 ASN T 17
REMARK 465 SER T 18
REMARK 465 GLY T 19
REMARK 465 ALA T 20
REMARK 465 MET U 1
REMARK 465 SER U 2
REMARK 465 ILE U 3
REMARK 465 GLN U 4
REMARK 465 THR U 5
REMARK 465 SER U 6
REMARK 465 ASP U 7
REMARK 465 PRO U 8
REMARK 465 ASN U 9
REMARK 465 GLU U 10
REMARK 465 THR U 11
REMARK 465 SER U 12
REMARK 465 ASP U 13
REMARK 465 LEU U 14
REMARK 465 PHE U 206
REMARK 465 ALA U 207
REMARK 465 ARG U 208
REMARK 465 SER U 209
REMARK 465 ARG U 210
REMARK 465 ASP U 211
REMARK 465 TYR U 212
REMARK 465 ASP U 213
REMARK 465 ALA U 214
REMARK 465 MET U 215
REMARK 465 GLY U 216
REMARK 465 ALA U 217
REMARK 465 ASP U 218
REMARK 465 THR U 219
REMARK 465 ARG U 220
REMARK 465 PHE U 221
REMARK 465 SER U 461
REMARK 465 ALA U 462
REMARK 465 ASP U 463
REMARK 465 PRO U 464
REMARK 465 ASP U 465
REMARK 465 ALA U 466
REMARK 465 MET U 467
REMARK 465 ASP U 468
REMARK 465 THR U 469
REMARK 465 THR U 470
REMARK 465 GLU U 471
REMARK 465 MET V 1
REMARK 465 VAL V 2
REMARK 465 ALA V 3
REMARK 465 ILE V 4
REMARK 465 SER V 5
REMARK 465 GLU V 6
REMARK 465 VAL V 7
REMARK 465 LYS V 8
REMARK 465 GLU V 9
REMARK 465 ASN V 10
REMARK 465 PRO V 11
REMARK 465 GLY V 12
REMARK 465 VAL V 13
REMARK 465 ASN V 14
REMARK 465 SER V 15
REMARK 465 SER V 16
REMARK 465 ASN V 17
REMARK 465 SER V 18
REMARK 465 GLY V 19
REMARK 465 ALA V 20
REMARK 465 ALA V 152
REMARK 465 GLU V 153
REMARK 465 ASN V 154
REMARK 465 PRO V 155
REMARK 465 LEU V 156
REMARK 465 GLY V 157
REMARK 465 GLY V 158
REMARK 465 TYR V 159
REMARK 465 GLY V 160
REMARK 465 MET W 1
REMARK 465 SER W 2
REMARK 465 ILE W 3
REMARK 465 GLN W 4
REMARK 465 THR W 5
REMARK 465 SER W 6
REMARK 465 ASP W 7
REMARK 465 PRO W 8
REMARK 465 ASN W 9
REMARK 465 GLU W 10
REMARK 465 THR W 11
REMARK 465 SER W 12
REMARK 465 ASP W 13
REMARK 465 ARG W 208
REMARK 465 SER W 209
REMARK 465 ARG W 210
REMARK 465 ASP W 211
REMARK 465 TYR W 212
REMARK 465 ASP W 213
REMARK 465 ALA W 214
REMARK 465 MET W 215
REMARK 465 GLY W 216
REMARK 465 ALA W 217
REMARK 465 ASP W 218
REMARK 465 THR W 219
REMARK 465 ARG W 220
REMARK 465 LYS W 460
REMARK 465 SER W 461
REMARK 465 ALA W 462
REMARK 465 ASP W 463
REMARK 465 PRO W 464
REMARK 465 ASP W 465
REMARK 465 ALA W 466
REMARK 465 MET W 467
REMARK 465 ASP W 468
REMARK 465 THR W 469
REMARK 465 THR W 470
REMARK 465 GLU W 471
REMARK 465 MET X 1
REMARK 465 VAL X 2
REMARK 465 ALA X 3
REMARK 465 ILE X 4
REMARK 465 SER X 5
REMARK 465 GLU X 6
REMARK 465 VAL X 7
REMARK 465 LYS X 8
REMARK 465 GLU X 9
REMARK 465 ASN X 10
REMARK 465 PRO X 11
REMARK 465 GLY X 12
REMARK 465 VAL X 13
REMARK 465 ASN X 14
REMARK 465 SER X 15
REMARK 465 SER X 16
REMARK 465 ASN X 17
REMARK 465 SER X 18
REMARK 465 GLY X 19
REMARK 465 ALA X 20
REMARK 465 VAL X 21
REMARK 465 MET Y 1
REMARK 465 SER Y 2
REMARK 465 ILE Y 3
REMARK 465 GLN Y 4
REMARK 465 THR Y 5
REMARK 465 SER Y 6
REMARK 465 ASP Y 7
REMARK 465 PRO Y 8
REMARK 465 ASN Y 9
REMARK 465 GLU Y 10
REMARK 465 THR Y 11
REMARK 465 SER Y 12
REMARK 465 ASP Y 13
REMARK 465 SER Y 461
REMARK 465 ALA Y 462
REMARK 465 ASP Y 463
REMARK 465 PRO Y 464
REMARK 465 ASP Y 465
REMARK 465 ALA Y 466
REMARK 465 MET Y 467
REMARK 465 ASP Y 468
REMARK 465 THR Y 469
REMARK 465 THR Y 470
REMARK 465 GLU Y 471
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 LYS A 37 CG CD CE NZ
REMARK 470 LYS B 37 CG CD CE NZ
REMARK 470 ILE C 21 CG1 CG2 CD1
REMARK 470 GLU M 743 CG CD OE1 OE2
REMARK 470 ARG M 783 CG CD NE CZ NH1 NH2
REMARK 470 LYS M 784 CG CD CE NZ
REMARK 470 LYS M 792 CG CD CE NZ
REMARK 470 CYS M 799 SG
REMARK 470 ARG M 817 CG CD NE CZ NH1 NH2
REMARK 470 ARG M 847 CG CD NE CZ NH1 NH2
REMARK 470 TRP M 864 CG CD1 CD2 NE1 CE2 CE3 CZ2
REMARK 470 TRP M 864 CZ3 CH2
REMARK 470 LYS M 879 CG CD CE NZ
REMARK 470 LYS M 880 CG CD CE NZ
REMARK 470 VAL M 881 CG1 CG2
REMARK 470 SER M 882 OG
REMARK 470 PHE M 884 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 GLU M 913 CG CD OE1 OE2
REMARK 470 THR M 914 OG1 CG2
REMARK 470 LYS M 915 CG CD CE NZ
REMARK 470 LYS M 916 CG CD CE NZ
REMARK 470 THR M 917 OG1 CG2
REMARK 470 LYS M 920 CG CD CE NZ
REMARK 470 GLN M 923 CG CD OE1 NE2
REMARK 470 GLU M 938 CG CD OE1 OE2
REMARK 470 LYS M 939 CG CD CE NZ
REMARK 470 ASP M1017 CG OD1 OD2
REMARK 470 GLN M1034 CG CD OE1 NE2
REMARK 470 GLU M1060 CG CD OE1 OE2
REMARK 470 GLN M1086 CG CD OE1 NE2
REMARK 470 GLU M1087 CG CD OE1 OE2
REMARK 470 GLU M1088 CG CD OE1 OE2
REMARK 470 PHE M1089 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 GLU M1091 CG CD OE1 OE2
REMARK 470 PHE M1094 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LEU M1095 CG CD1 CD2
REMARK 470 ASN M1096 CG OD1 ND2
REMARK 470 PHE M1097 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 GLN M1098 CG CD OE1 NE2
REMARK 470 ASP M1099 CG OD1 OD2
REMARK 470 ASN M1101 CG OD1 ND2
REMARK 470 GLN M1102 CG CD OE1 NE2
REMARK 470 TYR M1103 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 LYS M1109 CG CD CE NZ
REMARK 470 ARG M1129 CG CD NE CZ NH1 NH2
REMARK 470 LEU M1140 CG CD1 CD2
REMARK 470 ARG M1149 CG CD NE CZ NH1 NH2
REMARK 470 ILE M1157 CG1 CG2 CD1
REMARK 470 ASN M1160 CG OD1 ND2
REMARK 470 GLU M1161 CG CD OE1 OE2
REMARK 470 ASP M1191 CG OD1 OD2
REMARK 470 GLU M1207 CG CD OE1 OE2
REMARK 470 PHE M1235 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LYS M1247 CG CD CE NZ
REMARK 470 LYS M1250 CG CD CE NZ
REMARK 470 GLU M1299 CG CD OE1 OE2
REMARK 470 ASP M1311 CG OD1 OD2
REMARK 470 ASN M1344 CG OD1 ND2
REMARK 470 GLN M1388 CG CD OE1 NE2
REMARK 470 GLN M1395 CG CD OE1 NE2
REMARK 470 GLU M1396 CG CD OE1 OE2
REMARK 470 GLU T 153 CG CD OE1 OE2
REMARK 470 LYS T 161 CG CD CE NZ
REMARK 470 THR T 162 OG1 CG2
REMARK 470 ILE T 163 CG1 CG2 CD1
REMARK 470 LYS U 201 CG CD CE NZ
REMARK 470 ASP V 151 CG OD1 OD2
REMARK 470 LYS V 161 CG CD CE NZ
REMARK 470 GLN W 223 CG CD OE1 NE2
REMARK 470 GLU Y 137 CG CD OE1 OE2
REMARK 470 ASP Y 146 CG OD1 OD2
REMARK 470 ARG Y 147 CG CD NE CZ NH1 NH2
REMARK 470 SER Y 148 OG
REMARK 470 ILE Y 149 CG1 CG2 CD1
REMARK 470 THR Y 150 OG1 CG2
REMARK 470 HIS Y 153 CG ND1 CD2 CE1 NE2
REMARK 470 LYS Y 154 CG CD CE NZ
REMARK 470 LYS Y 181 CG CD CE NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 CE MET T 406 CD1 LEU T 418 1.49
REMARK 500 O1B ADP M 1601 F2 BEF M 1602 2.00
REMARK 500 PB ADP M 1601 BE BEF M 1602 2.05
REMARK 500 O3B ADP R 501 F2 BEF R 502 2.09
REMARK 500 N2 DG I -68 O2 DC J 68 2.13
REMARK 500 OG1 THR U 162 O MET U 165 2.14
REMARK 500 N2 DG I -52 O2 DC J 52 2.14
REMARK 500 O2 DC I -46 N2 DG J 46 2.16
REMARK 500 O2 DC I 10 N2 DG J -10 2.16
REMARK 500 O2 DC I -51 N2 DG J 51 2.16
REMARK 500 OG SER V 172 O GLY V 235 2.19
REMARK 500 OH TYR R 434 OD1 ASP S 221 2.19
REMARK 500 O ASN U 173 N ILE U 176 2.19
REMARK 500 O1B ADP R 501 F3 BEF R 502 2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 DA I -67 O4' - C1' - N9 ANGL. DEV. = 2.3 DEGREES
REMARK 500 DT I -59 O4' - C1' - N1 ANGL. DEV. = 1.9 DEGREES
REMARK 500 DT I -28 C3' - C2' - C1' ANGL. DEV. = -4.9 DEGREES
REMARK 500 DT I -28 O4' - C1' - N1 ANGL. DEV. = 2.4 DEGREES
REMARK 500 DC I -10 O4' - C1' - N1 ANGL. DEV. = 1.9 DEGREES
REMARK 500 DG I 48 O4' - C4' - C3' ANGL. DEV. = -2.8 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 UNK Z 82 -140.71 53.06
REMARK 500 UNK Z 90 -139.98 56.10
REMARK 500 UNK Z 96 -141.12 52.30
REMARK 500 UNK Z 97 173.45 175.62
REMARK 500 UNK Z 133 -74.17 -105.17
REMARK 500 UNK Z 134 -14.15 66.36
REMARK 500 UNK Z 135 -142.19 52.70
REMARK 500 UNK Z 146 -120.54 50.31
REMARK 500 UNK Z 148 -166.19 -78.82
REMARK 500 UNK Z 149 -172.71 -68.07
REMARK 500 UNK Z 150 -3.06 85.25
REMARK 500 UNK Z 153 -146.93 53.09
REMARK 500 UNK Z 154 163.15 171.95
REMARK 500 UNK Z 160 -70.58 -45.48
REMARK 500 UNK Z 161 -127.57 52.74
REMARK 500 UNK Z 180 -72.62 -93.23
REMARK 500 UNK Z 184 -121.62 52.09
REMARK 500 UNK Z 186 -76.56 -116.99
REMARK 500 UNK Z 194 -78.06 -120.27
REMARK 500 UNK Z 196 -135.67 56.68
REMARK 500 UNK Z 209 -69.14 -134.62
REMARK 500 PHE A 78 -70.23 -90.89
REMARK 500 ALA A 88 -15.04 72.48
REMARK 500 PHE B 78 -70.23 -90.92
REMARK 500 ALA B 88 -15.09 72.47
REMARK 500 LYS C 44 -69.28 -94.53
REMARK 500 THR C 96 71.89 56.90
REMARK 500 LYS D 44 -69.30 -94.50
REMARK 500 THR D 96 71.81 56.98
REMARK 500 THR E 25 -62.90 -126.90
REMARK 500 TYR E 40 -64.18 -98.40
REMARK 500 THR F 25 -62.92 -126.95
REMARK 500 TYR F 40 -64.21 -98.36
REMARK 500 ALA G 35 -70.22 -77.44
REMARK 500 THR G 51 -70.76 -93.13
REMARK 500 PRO G 53 48.21 -76.68
REMARK 500 ASP G 54 -64.43 -133.31
REMARK 500 THR H 51 -70.75 -93.16
REMARK 500 PRO H 53 48.22 -76.71
REMARK 500 ASP H 54 -64.50 -133.32
REMARK 500 ARG M 693 -36.98 -36.81
REMARK 500 TRP M 745 -77.42 -115.04
REMARK 500 ALA M 768 72.42 53.77
REMARK 500 GLN M 781 -63.14 -122.78
REMARK 500 TRP M 790 -62.47 -90.92
REMARK 500 GLN M 819 -64.63 -100.17
REMARK 500 GLU M 825 71.50 42.03
REMARK 500 THR M 854 139.06 -176.73
REMARK 500 ASN M 858 -169.82 -79.75
REMARK 500 ASN M 859 70.86 58.40
REMARK 500
REMARK 500 THIS ENTRY HAS 156 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 UNK Z 188 UNK Z 189 -139.72
REMARK 500 LEU M 692 ARG M 693 -143.52
REMARK 500 ASN M 1344 PRO M 1345 147.11
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN S 501 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS S 244 SG
REMARK 620 2 CYS S 247 SG 139.0
REMARK 620 3 CYS S 264 SG 103.1 87.4
REMARK 620 4 CYS S 268 SG 124.4 95.0 88.6
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN S 502 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS S 256 SG
REMARK 620 2 CYS S 259 SG 92.1
REMARK 620 3 HIS S 272 NE2 106.8 84.8
REMARK 620 4 CYS S 277 SG 145.5 106.6 103.6
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG V 502 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 THR V 86 OG1
REMARK 620 2 ADP V 501 O3B 100.2
REMARK 620 N 1
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG W 502 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 GLU W 297 OE2
REMARK 620 2 ADP W 501 O3B 152.7
REMARK 620 N 1
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG X 502 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 THR X 86 OG1
REMARK 620 2 ADP X 501 O3B 71.5
REMARK 620 N 1
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 MG Y 502 MG
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 THR Y 82 OG1
REMARK 620 2 ASP Y 296 OD1 125.6
REMARK 620 3 ASP Y 296 OD2 102.2 45.0
REMARK 620 4 GLU Y 297 OE2 146.7 61.0 101.0
REMARK 620 N 1 2 3
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 BEF M1602 BE
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ADP M1601 O1B
REMARK 620 2 BEF M1602 F1 121.3
REMARK 620 3 BEF M1602 F2 84.9 112.3
REMARK 620 4 BEF M1602 F3 117.9 109.7 107.2
REMARK 620 5 ADP M1601 O3B 86.9 77.1 169.9 71.8
REMARK 620 N 1 2 3 4
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 BEF R 502 BE
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 ADP R 501 O3B
REMARK 620 2 BEF R 502 F1 129.2
REMARK 620 3 BEF R 502 F2 89.4 112.4
REMARK 620 4 BEF R 502 F3 105.5 110.0 107.3
REMARK 620 N 1 2 3
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP M 1601
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue BEF M 1602
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG M 1603
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP R 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue BEF R 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG R 503
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN S 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN S 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP T 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG U 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP U 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG U 503
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP V 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG V 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP W 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG W 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP X 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG X 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP Y 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AE2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue MG Y 502
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-4395 RELATED DB: EMDB
REMARK 900 CHROMATIN REMODELLER-NUCLEOSOME COMPLEX AT 3.6 A RESOLUTION.
DBREF 6GEJ Z 81 211 PDB 6GEJ 6GEJ 81 211
DBREF 6GEJ A 0 135 UNP P61830 H3_YEAST 1 136
DBREF 6GEJ B 0 135 UNP P61830 H3_YEAST 1 136
DBREF 6GEJ C 0 102 UNP P02309 H4_YEAST 1 103
DBREF 6GEJ D 0 102 UNP P02309 H4_YEAST 1 103
DBREF 6GEJ E 0 131 UNP P04911 H2A1_YEAST 1 132
DBREF 6GEJ F 0 131 UNP P04911 H2A1_YEAST 1 132
DBREF 6GEJ G 0 130 UNP P02293 H2B1_YEAST 1 131
DBREF 6GEJ H 0 130 UNP P02293 H2B1_YEAST 1 131
DBREF 6GEJ I -77 76 PDB 6GEJ 6GEJ -77 76
DBREF 6GEJ J -76 77 PDB 6GEJ 6GEJ -76 77
DBREF 6GEJ M 1 1514 UNP Q05471 SWR1_YEAST 1 1514
DBREF 6GEJ R 1 438 UNP Q12509 ARP6_YEAST 1 438
DBREF 6GEJ S 1 280 UNP Q03433 VPS71_YEAST 1 280
DBREF 6GEJ T 1 463 UNP Q03940 RUVB1_YEAST 1 463
DBREF 6GEJ U 1 471 UNP Q12464 RUVB2_YEAST 1 471
DBREF 6GEJ V 1 463 UNP Q03940 RUVB1_YEAST 1 463
DBREF 6GEJ W 1 471 UNP Q12464 RUVB2_YEAST 1 471
DBREF 6GEJ X 1 463 UNP Q03940 RUVB1_YEAST 1 463
DBREF 6GEJ Y 1 471 UNP Q12464 RUVB2_YEAST 1 471
SEQADV 6GEJ GLU A 123 UNP P61830 ASP 124 CONFLICT
SEQADV 6GEJ GLU B 123 UNP P61830 ASP 124 CONFLICT
SEQRES 1 Z 131 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK
SEQRES 2 Z 131 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK
SEQRES 3 Z 131 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK
SEQRES 4 Z 131 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK
SEQRES 5 Z 131 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK
SEQRES 6 Z 131 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK
SEQRES 7 Z 131 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK
SEQRES 8 Z 131 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK
SEQRES 9 Z 131 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK
SEQRES 10 Z 131 UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK
SEQRES 11 Z 131 UNK
SEQRES 1 A 136 MET ALA ARG THR LYS GLN THR ALA ARG LYS SER THR GLY
SEQRES 2 A 136 GLY LYS ALA PRO ARG LYS GLN LEU ALA SER LYS ALA ALA
SEQRES 3 A 136 ARG LYS SER ALA PRO SER THR GLY GLY VAL LYS LYS PRO
SEQRES 4 A 136 HIS ARG TYR LYS PRO GLY THR VAL ALA LEU ARG GLU ILE
SEQRES 5 A 136 ARG ARG PHE GLN LYS SER THR GLU LEU LEU ILE ARG LYS
SEQRES 6 A 136 LEU PRO PHE GLN ARG LEU VAL ARG GLU ILE ALA GLN ASP
SEQRES 7 A 136 PHE LYS THR ASP LEU ARG PHE GLN SER SER ALA ILE GLY
SEQRES 8 A 136 ALA LEU GLN GLU SER VAL GLU ALA TYR LEU VAL SER LEU
SEQRES 9 A 136 PHE GLU ASP THR ASN LEU ALA ALA ILE HIS ALA LYS ARG
SEQRES 10 A 136 VAL THR ILE GLN LYS LYS GLU ILE LYS LEU ALA ARG ARG
SEQRES 11 A 136 LEU ARG GLY GLU ARG SER
SEQRES 1 B 136 MET ALA ARG THR LYS GLN THR ALA ARG LYS SER THR GLY
SEQRES 2 B 136 GLY LYS ALA PRO ARG LYS GLN LEU ALA SER LYS ALA ALA
SEQRES 3 B 136 ARG LYS SER ALA PRO SER THR GLY GLY VAL LYS LYS PRO
SEQRES 4 B 136 HIS ARG TYR LYS PRO GLY THR VAL ALA LEU ARG GLU ILE
SEQRES 5 B 136 ARG ARG PHE GLN LYS SER THR GLU LEU LEU ILE ARG LYS
SEQRES 6 B 136 LEU PRO PHE GLN ARG LEU VAL ARG GLU ILE ALA GLN ASP
SEQRES 7 B 136 PHE LYS THR ASP LEU ARG PHE GLN SER SER ALA ILE GLY
SEQRES 8 B 136 ALA LEU GLN GLU SER VAL GLU ALA TYR LEU VAL SER LEU
SEQRES 9 B 136 PHE GLU ASP THR ASN LEU ALA ALA ILE HIS ALA LYS ARG
SEQRES 10 B 136 VAL THR ILE GLN LYS LYS GLU ILE LYS LEU ALA ARG ARG
SEQRES 11 B 136 LEU ARG GLY GLU ARG SER
SEQRES 1 C 103 MET SER GLY ARG GLY LYS GLY GLY LYS GLY LEU GLY LYS
SEQRES 2 C 103 GLY GLY ALA LYS ARG HIS ARG LYS ILE LEU ARG ASP ASN
SEQRES 3 C 103 ILE GLN GLY ILE THR LYS PRO ALA ILE ARG ARG LEU ALA
SEQRES 4 C 103 ARG ARG GLY GLY VAL LYS ARG ILE SER GLY LEU ILE TYR
SEQRES 5 C 103 GLU GLU VAL ARG ALA VAL LEU LYS SER PHE LEU GLU SER
SEQRES 6 C 103 VAL ILE ARG ASP SER VAL THR TYR THR GLU HIS ALA LYS
SEQRES 7 C 103 ARG LYS THR VAL THR SER LEU ASP VAL VAL TYR ALA LEU
SEQRES 8 C 103 LYS ARG GLN GLY ARG THR LEU TYR GLY PHE GLY GLY
SEQRES 1 D 103 MET SER GLY ARG GLY LYS GLY GLY LYS GLY LEU GLY LYS
SEQRES 2 D 103 GLY GLY ALA LYS ARG HIS ARG LYS ILE LEU ARG ASP ASN
SEQRES 3 D 103 ILE GLN GLY ILE THR LYS PRO ALA ILE ARG ARG LEU ALA
SEQRES 4 D 103 ARG ARG GLY GLY VAL LYS ARG ILE SER GLY LEU ILE TYR
SEQRES 5 D 103 GLU GLU VAL ARG ALA VAL LEU LYS SER PHE LEU GLU SER
SEQRES 6 D 103 VAL ILE ARG ASP SER VAL THR TYR THR GLU HIS ALA LYS
SEQRES 7 D 103 ARG LYS THR VAL THR SER LEU ASP VAL VAL TYR ALA LEU
SEQRES 8 D 103 LYS ARG GLN GLY ARG THR LEU TYR GLY PHE GLY GLY
SEQRES 1 E 132 MET SER GLY GLY LYS GLY GLY LYS ALA GLY SER ALA ALA
SEQRES 2 E 132 LYS ALA SER GLN SER ARG SER ALA LYS ALA GLY LEU THR
SEQRES 3 E 132 PHE PRO VAL GLY ARG VAL HIS ARG LEU LEU ARG ARG GLY
SEQRES 4 E 132 ASN TYR ALA GLN ARG ILE GLY SER GLY ALA PRO VAL TYR
SEQRES 5 E 132 LEU THR ALA VAL LEU GLU TYR LEU ALA ALA GLU ILE LEU
SEQRES 6 E 132 GLU LEU ALA GLY ASN ALA ALA ARG ASP ASN LYS LYS THR
SEQRES 7 E 132 ARG ILE ILE PRO ARG HIS LEU GLN LEU ALA ILE ARG ASN
SEQRES 8 E 132 ASP ASP GLU LEU ASN LYS LEU LEU GLY ASN VAL THR ILE
SEQRES 9 E 132 ALA GLN GLY GLY VAL LEU PRO ASN ILE HIS GLN ASN LEU
SEQRES 10 E 132 LEU PRO LYS LYS SER ALA LYS ALA THR LYS ALA SER GLN
SEQRES 11 E 132 GLU LEU
SEQRES 1 F 132 MET SER GLY GLY LYS GLY GLY LYS ALA GLY SER ALA ALA
SEQRES 2 F 132 LYS ALA SER GLN SER ARG SER ALA LYS ALA GLY LEU THR
SEQRES 3 F 132 PHE PRO VAL GLY ARG VAL HIS ARG LEU LEU ARG ARG GLY
SEQRES 4 F 132 ASN TYR ALA GLN ARG ILE GLY SER GLY ALA PRO VAL TYR
SEQRES 5 F 132 LEU THR ALA VAL LEU GLU TYR LEU ALA ALA GLU ILE LEU
SEQRES 6 F 132 GLU LEU ALA GLY ASN ALA ALA ARG ASP ASN LYS LYS THR
SEQRES 7 F 132 ARG ILE ILE PRO ARG HIS LEU GLN LEU ALA ILE ARG ASN
SEQRES 8 F 132 ASP ASP GLU LEU ASN LYS LEU LEU GLY ASN VAL THR ILE
SEQRES 9 F 132 ALA GLN GLY GLY VAL LEU PRO ASN ILE HIS GLN ASN LEU
SEQRES 10 F 132 LEU PRO LYS LYS SER ALA LYS ALA THR LYS ALA SER GLN
SEQRES 11 F 132 GLU LEU
SEQRES 1 G 131 MET SER ALA LYS ALA GLU LYS LYS PRO ALA SER LYS ALA
SEQRES 2 G 131 PRO ALA GLU LYS LYS PRO ALA ALA LYS LYS THR SER THR
SEQRES 3 G 131 SER THR ASP GLY LYS LYS ARG SER LYS ALA ARG LYS GLU
SEQRES 4 G 131 THR TYR SER SER TYR ILE TYR LYS VAL LEU LYS GLN THR
SEQRES 5 G 131 HIS PRO ASP THR GLY ILE SER GLN LYS SER MET SER ILE
SEQRES 6 G 131 LEU ASN SER PHE VAL ASN ASP ILE PHE GLU ARG ILE ALA
SEQRES 7 G 131 THR GLU ALA SER LYS LEU ALA ALA TYR ASN LYS LYS SER
SEQRES 8 G 131 THR ILE SER ALA ARG GLU ILE GLN THR ALA VAL ARG LEU
SEQRES 9 G 131 ILE LEU PRO GLY GLU LEU ALA LYS HIS ALA VAL SER GLU
SEQRES 10 G 131 GLY THR ARG ALA VAL THR LYS TYR SER SER SER THR GLN
SEQRES 11 G 131 ALA
SEQRES 1 H 131 MET SER ALA LYS ALA GLU LYS LYS PRO ALA SER LYS ALA
SEQRES 2 H 131 PRO ALA GLU LYS LYS PRO ALA ALA LYS LYS THR SER THR
SEQRES 3 H 131 SER THR ASP GLY LYS LYS ARG SER LYS ALA ARG LYS GLU
SEQRES 4 H 131 THR TYR SER SER TYR ILE TYR LYS VAL LEU LYS GLN THR
SEQRES 5 H 131 HIS PRO ASP THR GLY ILE SER GLN LYS SER MET SER ILE
SEQRES 6 H 131 LEU ASN SER PHE VAL ASN ASP ILE PHE GLU ARG ILE ALA
SEQRES 7 H 131 THR GLU ALA SER LYS LEU ALA ALA TYR ASN LYS LYS SER
SEQRES 8 H 131 THR ILE SER ALA ARG GLU ILE GLN THR ALA VAL ARG LEU
SEQRES 9 H 131 ILE LEU PRO GLY GLU LEU ALA LYS HIS ALA VAL SER GLU
SEQRES 10 H 131 GLY THR ARG ALA VAL THR LYS TYR SER SER SER THR GLN
SEQRES 11 H 131 ALA
SEQRES 1 I 154 DC DG DC DC DC DT DG DG DA DG DA DA DT
SEQRES 2 I 154 DC DC DC DG DG DT DG DC DC DG DA DG DG
SEQRES 3 I 154 DC DC DG DC DT DC DA DA DT DT DG DG DT
SEQRES 4 I 154 DC DG DT DA DG DA DC DA DG DC DT DC DT
SEQRES 5 I 154 DA DG DC DA DC DC DG DC DT DT DA DA DA
SEQRES 6 I 154 DC DG DC DA DC DG DT DA DC DG DC DG DC
SEQRES 7 I 154 DT DG DT DC DC DC DC DC DG DC DG DT DT
SEQRES 8 I 154 DT DT DA DA DC DC DG DC DC DA DA DG DG
SEQRES 9 I 154 DG DG DA DT DT DA DC DT DC DC DC DT DA
SEQRES 10 I 154 DG DT DC DT DC DC DA DG DG DC DA DC DG
SEQRES 11 I 154 DT DG DT DC DA DG DA DT DA DT DA DT DA
SEQRES 12 I 154 DC DA DT DC DC DT DG DT DG DC DA
SEQRES 1 J 154 DT DG DC DA DC DA DG DG DA DT DG DT DA
SEQRES 2 J 154 DT DA DT DA DT DC DT DG DA DC DA DC DG
SEQRES 3 J 154 DT DG DC DC DT DG DG DA DG DA DC DT DA
SEQRES 4 J 154 DG DG DG DA DG DT DA DA DT DC DC DC DC
SEQRES 5 J 154 DT DT DG DG DC DG DG DT DT DA DA DA DA
SEQRES 6 J 154 DC DG DC DG DG DG DG DG DA DC DA DG DC
SEQRES 7 J 154 DG DC DG DT DA DC DG DT DG DC DG DT DT
SEQRES 8 J 154 DT DA DA DG DC DG DG DT DG DC DT DA DG
SEQRES 9 J 154 DA DG DC DT DG DT DC DT DA DC DG DA DC
SEQRES 10 J 154 DC DA DA DT DT DG DA DG DC DG DG DC DC
SEQRES 11 J 154 DT DC DG DG DC DA DC DC DG DG DG DA DT
SEQRES 12 J 154 DT DC DT DC DC DA DG DG DG DC DG
SEQRES 1 M 1514 MET THR THR SER ARG LYS SER HIS ALA LYS ASP LYS LYS
SEQRES 2 M 1514 ALA GLY GLY GLU GLN ASP LEU ALA ASP LEU LYS PHE ARG
SEQRES 3 M 1514 TYR ASP LEU LEU THR ASN GLU LEU PHE HIS LEU ARG GLU
SEQRES 4 M 1514 PHE VAL SER LEU VAL ASP TYR ASP PRO THR HIS PHE ASN
SEQRES 5 M 1514 ASP SER GLU SER PHE GLN LYS PHE LEU ARG GLU THR HIS
SEQRES 6 M 1514 LEU SER LEU GLU GLU ARG GLY GLU LYS PHE THR ASP ASP
SEQRES 7 M 1514 VAL ALA LYS LYS GLY THR ASN GLY ASP LEU THR ARG ARG
SEQRES 8 M 1514 ARG ARG ASN LEU ARG THR SER THR VAL VAL SER SER GLU
SEQRES 9 M 1514 THR THR ASN GLU LYS LYS GLY ASP ILE GLU LEU LYS LEU
SEQRES 10 M 1514 GLU SER ILE ALA PRO LEU VAL ARG ASN LYS CYS GLU GLU
SEQRES 11 M 1514 LEU LYS TYR LYS LEU SER ASP HIS SER ASN ARG LYS SER
SEQRES 12 M 1514 ILE VAL PRO GLN LYS ARG PRO ILE GLN HIS LEU LYS LYS
SEQRES 13 M 1514 ARG GLU ALA ALA LYS SER LEU LYS PHE LYS SER GLU ARG
SEQRES 14 M 1514 LYS GLU ASN PRO LEU PRO LEU HIS GLU HIS ILE ALA GLU
SEQRES 15 M 1514 GLU ARG TYR ASP HIS ILE ALA LYS VAL GLU GLU PRO SER
SEQRES 16 M 1514 GLU ALA PHE THR ILE LYS CYS PRO SER ASP ASP SER SER
SEQRES 17 M 1514 PHE GLU ASN THR SER GLU HIS TYR SER ASP ASN PHE TYR
SEQRES 18 M 1514 PHE THR THR SER SER GLU GLU GLU ASP ILE LYS LYS LYS
SEQRES 19 M 1514 ARG GLY ARG LYS LYS LYS LYS PRO ARG ILE LYS LEU VAL
SEQRES 20 M 1514 VAL HIS PRO PRO LYS GLN THR ILE THR ASN PRO LEU HIS
SEQRES 21 M 1514 VAL VAL LYS PRO GLY TYR GLU SER LEU HIS GLU TYR ILE
SEQRES 22 M 1514 ALA SER PHE LYS SER LEU GLU ASP ASP LEU THR LEU GLU
SEQRES 23 M 1514 GLU TYR ASN LYS TYR ILE ASP GLU GLN ARG ARG LEU LEU
SEQRES 24 M 1514 SER ARG LEU LYS LYS GLY ILE GLU ASN GLY ALA LEU LYS
SEQRES 25 M 1514 TYR ASP LYS GLU THR ASP SER LEU GLN PRO ILE THR SER
SEQRES 26 M 1514 LYS GLU ILE LYS THR ILE ILE THR TYR LYS PRO ASP PRO
SEQRES 27 M 1514 ILE SER TYR PHE TYR LYS GLN GLN ASP LEU GLN ILE HIS
SEQRES 28 M 1514 THR ASP HIS LEU ILE ASN GLN GLY ILE HIS MET SER LYS
SEQRES 29 M 1514 LEU PHE ARG SER SER THR LYS ALA ARG ILE ALA ARG ALA
SEQRES 30 M 1514 LYS LYS VAL SER GLN MET ILE GLU GLN HIS PHE LYS HIS
SEQRES 31 M 1514 VAL ALA GLY ALA GLU GLU ARG LYS ALA LYS GLU GLU GLU
SEQRES 32 M 1514 ARG HIS LYS LYS SER LEU ALA ARG PHE ALA VAL GLN ALA
SEQRES 33 M 1514 VAL LYS LYS ARG TRP ASN MET ALA GLU LYS ALA TYR ARG
SEQRES 34 M 1514 ILE LEU ARG LYS ASP GLU GLU GLU GLN LEU LYS ARG ILE
SEQRES 35 M 1514 GLU GLY LYS GLN HIS LEU SER LYS MET LEU GLU LYS SER
SEQRES 36 M 1514 THR GLN LEU LEU GLU ALA GLN LEU ASN GLN VAL ASN ASP
SEQRES 37 M 1514 ASP GLY ARG SER SER THR PRO SER SER ASP SER ASN ASP
SEQRES 38 M 1514 VAL LEU SER GLU SER ASP ASP ASP MET ASP ASP GLU LEU
SEQRES 39 M 1514 SER THR SER SER ASP GLU ASP GLU GLU VAL ASP ALA ASP
SEQRES 40 M 1514 VAL GLY LEU GLU ASN SER PRO ALA SER THR GLU ALA THR
SEQRES 41 M 1514 PRO THR ASP GLU SER LEU ASN LEU ILE GLN LEU LYS GLU
SEQRES 42 M 1514 LYS TYR GLY HIS PHE ASN GLY SER SER THR VAL TYR ASP
SEQRES 43 M 1514 SER ARG ASN LYS ASP GLU LYS PHE PRO THR LEU ASP LYS
SEQRES 44 M 1514 HIS GLU SER SER SER SER GLU SER SER VAL MET THR GLY
SEQRES 45 M 1514 GLU GLU SER SER ILE TYR SER SER SER GLU ASN GLU SER
SEQRES 46 M 1514 GLN ASN GLU ASN ASP ARG GLU SER ASP ASP LYS THR PRO
SEQRES 47 M 1514 SER VAL GLY LEU SER ALA LEU PHE GLY LYS GLY GLU GLU
SEQRES 48 M 1514 SER ASP GLY ASP LEU ASP LEU ASP ASP SER GLU ASP PHE
SEQRES 49 M 1514 THR VAL ASN SER SER SER VAL GLU GLY GLU GLU LEU GLU
SEQRES 50 M 1514 LYS ASP GLN VAL ASP ASN SER ALA ALA THR PHE GLU ARG
SEQRES 51 M 1514 ALA GLY ASP PHE VAL HIS THR GLN ASN GLU ASN ARG ASP
SEQRES 52 M 1514 ASP ILE LYS ASP VAL GLU GLU ASP ALA GLU THR LYS VAL
SEQRES 53 M 1514 GLN GLU GLU GLN LEU SER VAL VAL ASP VAL PRO VAL PRO
SEQRES 54 M 1514 SER LEU LEU ARG GLY ASN LEU ARG THR TYR GLN LYS GLN
SEQRES 55 M 1514 GLY LEU ASN TRP LEU ALA SER LEU TYR ASN ASN HIS THR
SEQRES 56 M 1514 ASN GLY ILE LEU ALA ASP GLU MET GLY LEU GLY LYS THR
SEQRES 57 M 1514 ILE GLN THR ILE SER LEU LEU ALA TYR LEU ALA CYS GLU
SEQRES 58 M 1514 LYS GLU ASN TRP GLY PRO HIS LEU ILE VAL VAL PRO THR
SEQRES 59 M 1514 SER VAL LEU LEU ASN TRP GLU MET GLU PHE LYS ARG PHE
SEQRES 60 M 1514 ALA PRO GLY PHE LYS VAL LEU THR TYR TYR GLY SER PRO
SEQRES 61 M 1514 GLN GLN ARG LYS GLU LYS ARG LYS GLY TRP ASN LYS PRO
SEQRES 62 M 1514 ASP ALA PHE HIS VAL CYS ILE VAL SER TYR GLN LEU VAL
SEQRES 63 M 1514 VAL GLN ASP GLN HIS SER PHE LYS ARG LYS ARG TRP GLN
SEQRES 64 M 1514 TYR MET VAL LEU ASP GLU ALA HIS ASN ILE LYS ASN PHE
SEQRES 65 M 1514 ARG SER THR ARG TRP GLN ALA LEU LEU ASN PHE ASN THR
SEQRES 66 M 1514 GLN ARG ARG LEU LEU LEU THR GLY THR PRO LEU GLN ASN
SEQRES 67 M 1514 ASN LEU ALA GLU LEU TRP SER LEU LEU TYR PHE LEU MET
SEQRES 68 M 1514 PRO GLN THR VAL ILE ASP GLY LYS LYS VAL SER GLY PHE
SEQRES 69 M 1514 ALA ASP LEU ASP ALA PHE GLN GLN TRP PHE GLY ARG PRO
SEQRES 70 M 1514 VAL ASP LYS ILE ILE GLU THR GLY GLN ASN PHE GLY GLN
SEQRES 71 M 1514 ASP LYS GLU THR LYS LYS THR VAL ALA LYS LEU HIS GLN
SEQRES 72 M 1514 VAL LEU ARG PRO TYR LEU LEU ARG ARG LEU LYS ALA ASP
SEQRES 73 M 1514 VAL GLU LYS GLN MET PRO ALA LYS TYR GLU HIS ILE VAL
SEQRES 74 M 1514 TYR CYS LYS LEU SER LYS ARG GLN ARG PHE LEU TYR ASP
SEQRES 75 M 1514 ASP PHE MET SER ARG ALA GLN THR LYS ALA THR LEU ALA
SEQRES 76 M 1514 SER GLY ASN PHE MET SER ILE VAL ASN CYS LEU MET GLN
SEQRES 77 M 1514 LEU ARG LYS VAL CYS ASN HIS PRO ASN LEU PHE GLU VAL
SEQRES 78 M 1514 ARG PRO ILE LEU THR SER PHE VAL LEU GLU HIS CYS VAL
SEQRES 79 M 1514 ALA SER ASP TYR LYS ASP VAL GLU ARG THR LEU LEU LYS
SEQRES 80 M 1514 LEU PHE LYS LYS ASN ASN GLN VAL ASN ARG VAL ASP LEU
SEQRES 81 M 1514 ASP PHE LEU ASN LEU VAL PHE THR LEU ASN ASP LYS ASP
SEQRES 82 M 1514 LEU THR SER TYR HIS ALA GLU GLU ILE SER LYS LEU THR
SEQRES 83 M 1514 CYS VAL LYS ASN PHE VAL GLU GLU VAL ASN LYS LEU ARG
SEQRES 84 M 1514 GLU THR ASN LYS GLN LEU GLN GLU GLU PHE GLY GLU ALA
SEQRES 85 M 1514 SER PHE LEU ASN PHE GLN ASP ALA ASN GLN TYR PHE LYS
SEQRES 86 M 1514 TYR SER ASN LYS GLN LYS LEU GLU GLY THR VAL ASP MET
SEQRES 87 M 1514 LEU ASN PHE LEU LYS MET VAL ASN LYS LEU ARG CYS ASP
SEQRES 88 M 1514 ARG ARG PRO ILE PHE GLY LYS ASN LEU ILE ASP LEU LEU
SEQRES 89 M 1514 THR LYS ASP ARG ARG VAL LYS TYR ASP LYS SER SER ILE
SEQRES 90 M 1514 ILE ASP ASN GLU LEU ILE LYS PRO LEU GLN THR ARG VAL
SEQRES 91 M 1514 LEU ASP ASN ARG LYS ILE ILE ASP THR PHE ALA VAL LEU
SEQRES 92 M 1514 THR PRO SER ALA VAL SER LEU ASP MET ARG LYS LEU ALA
SEQRES 93 M 1514 LEU GLY LEU ASN ASP ASP SER SER VAL GLY GLU ASN THR
SEQRES 94 M 1514 ARG LEU LYS VAL MET GLN ASN CYS PHE GLU VAL SER ASN
SEQRES 95 M 1514 PRO LEU HIS GLN LEU GLN THR LYS LEU THR ILE ALA PHE
SEQRES 96 M 1514 PRO ASP LYS SER LEU LEU GLN TYR ASP CYS GLY LYS LEU
SEQRES 97 M 1514 GLN LYS LEU ALA ILE LEU LEU GLN GLN LEU LYS ASP ASN
SEQRES 98 M 1514 GLY HIS ARG ALA LEU ILE PHE THR GLN MET THR LYS VAL
SEQRES 99 M 1514 LEU ASP VAL LEU GLU GLN PHE LEU ASN TYR HIS GLY TYR
SEQRES 100 M 1514 LEU TYR MET ARG LEU ASP GLY ALA THR LYS ILE GLU ASP
SEQRES 101 M 1514 ARG GLN ILE LEU THR GLU ARG PHE ASN THR ASP SER ARG
SEQRES 102 M 1514 ILE THR VAL PHE ILE LEU SER SER ARG SER GLY GLY LEU
SEQRES 103 M 1514 GLY ILE ASN LEU THR GLY ALA ASP THR VAL ILE PHE TYR
SEQRES 104 M 1514 ASP SER ASP TRP ASN PRO ALA MET ASP LYS GLN CYS GLN
SEQRES 105 M 1514 ASP ARG CYS HIS ARG ILE GLY GLN THR ARG ASP VAL HIS
SEQRES 106 M 1514 ILE TYR ARG PHE VAL SER GLU HIS THR ILE GLU SER ASN
SEQRES 107 M 1514 ILE LEU LYS LYS ALA ASN GLN LYS ARG GLN LEU ASP ASN
SEQRES 108 M 1514 VAL VAL ILE GLN GLU GLY ASP PHE THR THR ASP TYR PHE
SEQRES 109 M 1514 SER LYS LEU SER VAL ARG ASP LEU LEU GLY SER GLU LEU
SEQRES 110 M 1514 PRO GLU ASN ALA SER GLY GLY ASP LYS PRO LEU ILE ALA
SEQRES 111 M 1514 ASP ALA ASP VAL ALA ALA LYS ASP PRO ARG GLN LEU GLU
SEQRES 112 M 1514 ARG LEU LEU ALA GLN ALA GLU ASP GLU ASP ASP VAL LYS
SEQRES 113 M 1514 ALA ALA ASN LEU ALA MET ARG GLU VAL GLU ILE ASP ASN
SEQRES 114 M 1514 ASP ASP PHE ASP GLU SER THR GLU LYS LYS ALA ALA ASN
SEQRES 115 M 1514 GLU GLU GLU GLU ASN HIS ALA GLU LEU ASP GLU TYR GLU
SEQRES 116 M 1514 GLY THR ALA HIS VAL ASP GLU TYR MET ILE ARG PHE ILE
SEQRES 117 M 1514 ALA ASN GLY TYR TYR TYR
SEQRES 1 R 438 MET GLU THR PRO PRO ILE VAL ILE ASP ASN GLY SER TYR
SEQRES 2 R 438 GLU ILE LYS PHE GLY PRO SER THR ASN LYS LYS PRO PHE
SEQRES 3 R 438 ARG ALA LEU ASN ALA LEU ALA LYS ASP LYS PHE GLY THR
SEQRES 4 R 438 SER TYR LEU SER ASN HIS ILE LYS ASN ILE LYS ASP ILE
SEQRES 5 R 438 SER SER ILE THR PHE ARG ARG PRO HIS GLU LEU GLY GLN
SEQRES 6 R 438 LEU THR LEU TRP GLU LEU GLU SER CYS ILE TRP ASP TYR
SEQRES 7 R 438 CYS LEU PHE ASN PRO SER GLU PHE ASP GLY PHE ASP LEU
SEQRES 8 R 438 LYS GLU GLY LYS GLY HIS HIS LEU VAL ALA SER GLU SER
SEQRES 9 R 438 CYS MET THR LEU PRO GLU LEU SER LYS HIS ALA ASP GLN
SEQRES 10 R 438 VAL ILE PHE GLU GLU TYR GLU PHE ASP SER LEU PHE LYS
SEQRES 11 R 438 SER PRO VAL ALA VAL PHE VAL PRO PHE THR LYS SER TYR
SEQRES 12 R 438 LYS GLY GLU MET ARG THR ILE SER GLY LYS ASP GLU ASP
SEQRES 13 R 438 ILE ASP ILE VAL ARG GLY ASN SER ASP SER THR ASN SER
SEQRES 14 R 438 THR SER SER GLU SER LYS ASN ALA GLN ASP SER GLY SER
SEQRES 15 R 438 ASP TYR HIS ASP PHE GLN LEU VAL ILE ASP SER GLY PHE
SEQRES 16 R 438 ASN CYS THR TRP ILE ILE PRO VAL LEU LYS GLY ILE PRO
SEQRES 17 R 438 TYR TYR LYS ALA VAL LYS LYS LEU ASP ILE GLY GLY ARG
SEQRES 18 R 438 PHE LEU THR GLY LEU LEU LYS GLU THR LEU SER PHE ARG
SEQRES 19 R 438 HIS TYR ASN MET MET ASP GLU THR ILE LEU VAL ASN ASN
SEQRES 20 R 438 ILE LYS GLU GLN CYS LEU PHE VAL SER PRO VAL SER TYR
SEQRES 21 R 438 PHE ASP SER PHE LYS THR LYS ASP LYS HIS ALA LEU GLU
SEQRES 22 R 438 TYR VAL LEU PRO ASP PHE GLN THR SER PHE LEU GLY TYR
SEQRES 23 R 438 VAL ARG ASN PRO ARG LYS GLU ASN VAL PRO LEU PRO GLU
SEQRES 24 R 438 ASP ALA GLN ILE ILE THR LEU THR ASP GLU LEU PHE THR
SEQRES 25 R 438 ILE PRO GLU THR PHE PHE HIS PRO GLU ILE SER GLN ILE
SEQRES 26 R 438 THR LYS PRO GLY ILE VAL GLU ALA ILE LEU GLU SER LEU
SEQRES 27 R 438 SER MET LEU PRO GLU ILE VAL ARG PRO LEU MET VAL GLY
SEQRES 28 R 438 ASN ILE VAL CYS THR GLY GLY ASN PHE ASN LEU PRO ASN
SEQRES 29 R 438 PHE ALA GLN ARG LEU ALA ALA GLU LEU GLN ARG GLN LEU
SEQRES 30 R 438 PRO THR ASP TRP THR CYS HIS VAL SER VAL PRO GLU GLY
SEQRES 31 R 438 ASP CYS ALA LEU PHE GLY TRP GLU VAL MET SER GLN PHE
SEQRES 32 R 438 ALA LYS THR ASP SER TYR ARG LYS ALA ARG VAL THR ARG
SEQRES 33 R 438 GLU GLU TYR TYR GLU HIS GLY PRO ASP TRP CYS THR LYS
SEQRES 34 R 438 HIS ARG PHE GLY TYR GLN ASN TRP ILE
SEQRES 1 S 280 MET LYS ALA LEU VAL GLU GLU ILE ASP LYS LYS THR TYR
SEQRES 2 S 280 ASN PRO ASP ILE TYR PHE THR SER LEU ASP PRO GLN ALA
SEQRES 3 S 280 ARG ARG TYR THR SER LYS LYS ILE ASN LYS GLN GLY THR
SEQRES 4 S 280 ILE SER THR SER ARG PRO VAL LYS ARG ILE ASN TYR SER
SEQRES 5 S 280 LEU ALA ASP LEU GLU ALA ARG LEU TYR THR SER ARG SER
SEQRES 6 S 280 GLU GLY ASP GLY ASN SER ILE SER ARG GLN ASP ASP ARG
SEQRES 7 S 280 ASN SER LYS ASN SER HIS SER PHE GLU GLU ARG TYR THR
SEQRES 8 S 280 GLN GLN GLU ILE LEU GLN SER ASP ARG ARG PHE MET GLU
SEQRES 9 S 280 LEU ASN THR GLU ASN PHE SER ASP LEU PRO ASN VAL PRO
SEQRES 10 S 280 THR LEU LEU SER ASP LEU THR GLY VAL PRO ARG ASP ARG
SEQRES 11 S 280 ILE GLU SER THR THR LYS PRO ILE SER GLN THR SER ASP
SEQRES 12 S 280 GLY LEU SER ALA LEU MET GLY GLY SER SER PHE VAL LYS
SEQRES 13 S 280 GLU HIS SER LYS TYR GLY HIS GLY TRP VAL LEU LYS PRO
SEQRES 14 S 280 GLU THR LEU ARG GLU ILE GLN LEU SER TYR LYS SER THR
SEQRES 15 S 280 LYS LEU PRO LYS PRO LYS ARG LYS ASN THR ASN ARG ILE
SEQRES 16 S 280 VAL ALA LEU LYS LYS VAL LEU SER SER LYS ARG ASN LEU
SEQRES 17 S 280 HIS SER PHE LEU ASP SER ALA LEU LEU ASN LEU MET ASP
SEQRES 18 S 280 LYS ASN VAL ILE TYR HIS ASN VAL TYR ASN LYS ARG TYR
SEQRES 19 S 280 PHE LYS VAL LEU PRO LEU ILE THR THR CYS SER ILE CYS
SEQRES 20 S 280 GLY GLY TYR ASP SER ILE SER SER CYS VAL ASN CYS GLY
SEQRES 21 S 280 ASN LYS ILE CYS SER VAL SER CYS PHE LYS LEU HIS ASN
SEQRES 22 S 280 GLU THR ARG CYS ARG ASN ARG
SEQRES 1 T 463 MET VAL ALA ILE SER GLU VAL LYS GLU ASN PRO GLY VAL
SEQRES 2 T 463 ASN SER SER ASN SER GLY ALA VAL THR ARG THR ALA ALA
SEQRES 3 T 463 HIS THR HIS ILE LYS GLY LEU GLY LEU ASP GLU SER GLY
SEQRES 4 T 463 VAL ALA LYS ARG VAL GLU GLY GLY PHE VAL GLY GLN ILE
SEQRES 5 T 463 GLU ALA ARG GLU ALA CYS GLY VAL ILE VAL ASP LEU ILE
SEQRES 6 T 463 LYS ALA LYS LYS MET SER GLY ARG ALA ILE LEU LEU ALA
SEQRES 7 T 463 GLY GLY PRO SER THR GLY LYS THR ALA LEU ALA LEU ALA
SEQRES 8 T 463 ILE SER GLN GLU LEU GLY PRO LYS VAL PRO PHE CYS PRO
SEQRES 9 T 463 LEU VAL GLY SER GLU LEU TYR SER VAL GLU VAL LYS LYS
SEQRES 10 T 463 THR GLU THR LEU MET GLU ASN PHE ARG ARG ALA ILE GLY
SEQRES 11 T 463 LEU ARG ILE LYS GLU THR LYS GLU VAL TYR GLU GLY GLU
SEQRES 12 T 463 VAL THR GLU LEU THR PRO GLU ASP ALA GLU ASN PRO LEU
SEQRES 13 T 463 GLY GLY TYR GLY LYS THR ILE SER HIS VAL ILE VAL GLY
SEQRES 14 T 463 LEU LYS SER ALA LYS GLY THR LYS THR LEU ARG LEU ASP
SEQRES 15 T 463 PRO THR ILE TYR GLU SER ILE GLN ARG GLU LYS VAL SER
SEQRES 16 T 463 ILE GLY ASP VAL ILE TYR ILE GLU ALA ASN THR GLY ALA
SEQRES 17 T 463 VAL LYS ARG VAL GLY ARG SER ASP ALA TYR ALA THR GLU
SEQRES 18 T 463 PHE ASP LEU GLU THR GLU GLU TYR VAL PRO LEU PRO LYS
SEQRES 19 T 463 GLY GLU VAL HIS LYS LYS LYS GLU ILE VAL GLN ASP VAL
SEQRES 20 T 463 THR LEU HIS ASP LEU ASP VAL ALA ASN ALA ARG PRO GLN
SEQRES 21 T 463 GLY GLY GLN ASP VAL ILE SER MET MET GLY GLN LEU LEU
SEQRES 22 T 463 LYS PRO LYS LYS THR GLU ILE THR GLU LYS LEU ARG GLN
SEQRES 23 T 463 GLU VAL ASN LYS VAL VAL ALA LYS TYR ILE ASP GLN GLY
SEQRES 24 T 463 VAL ALA GLU LEU ILE PRO GLY VAL LEU PHE ILE ASP GLU
SEQRES 25 T 463 VAL ASN MET LEU ASP ILE GLU ILE PHE THR TYR LEU ASN
SEQRES 26 T 463 LYS ALA LEU GLU SER ASN ILE ALA PRO VAL VAL VAL LEU
SEQRES 27 T 463 ALA SER ASN ARG GLY MET THR THR VAL ARG GLY THR GLU
SEQRES 28 T 463 ASP VAL ILE SER PRO HIS GLY VAL PRO PRO ASP LEU ILE
SEQRES 29 T 463 ASP ARG LEU LEU ILE VAL ARG THR LEU PRO TYR ASP LYS
SEQRES 30 T 463 ASP GLU ILE ARG THR ILE ILE GLU ARG ARG ALA THR VAL
SEQRES 31 T 463 GLU ARG LEU GLN VAL GLU SER SER ALA LEU ASP LEU LEU
SEQRES 32 T 463 ALA THR MET GLY THR GLU THR SER LEU ARG TYR ALA LEU
SEQRES 33 T 463 GLN LEU LEU ALA PRO CYS GLY ILE LEU ALA GLN THR SER
SEQRES 34 T 463 ASN ARG LYS GLU ILE VAL VAL ASN ASP VAL ASN GLU ALA
SEQRES 35 T 463 LYS LEU LEU PHE LEU ASP ALA LYS ARG SER THR LYS ILE
SEQRES 36 T 463 LEU GLU THR SER ALA ASN TYR LEU
SEQRES 1 U 471 MET SER ILE GLN THR SER ASP PRO ASN GLU THR SER ASP
SEQRES 2 U 471 LEU LYS SER LEU SER LEU ILE ALA ALA HIS SER HIS ILE
SEQRES 3 U 471 THR GLY LEU GLY LEU ASP GLU ASN LEU GLN PRO ARG PRO
SEQRES 4 U 471 THR SER GLU GLY MET VAL GLY GLN LEU GLN ALA ARG ARG
SEQRES 5 U 471 ALA ALA GLY VAL ILE LEU LYS MET VAL GLN ASN GLY THR
SEQRES 6 U 471 ILE ALA GLY ARG ALA VAL LEU VAL ALA GLY PRO PRO SER
SEQRES 7 U 471 THR GLY LYS THR ALA LEU ALA MET GLY VAL SER GLN SER
SEQRES 8 U 471 LEU GLY LYS ASP VAL PRO PHE THR ALA ILE ALA GLY SER
SEQRES 9 U 471 GLU ILE PHE SER LEU GLU LEU SER LYS THR GLU ALA LEU
SEQRES 10 U 471 THR GLN ALA PHE ARG LYS SER ILE GLY ILE LYS ILE LYS
SEQRES 11 U 471 GLU GLU THR GLU LEU ILE GLU GLY GLU VAL VAL GLU ILE
SEQRES 12 U 471 GLN ILE ASP ARG SER ILE THR GLY GLY HIS LYS GLN GLY
SEQRES 13 U 471 LYS LEU THR ILE LYS THR THR ASP MET GLU THR ILE TYR
SEQRES 14 U 471 GLU LEU GLY ASN LYS MET ILE ASP GLY LEU THR LYS GLU
SEQRES 15 U 471 LYS VAL LEU ALA GLY ASP VAL ILE SER ILE ASP LYS ALA
SEQRES 16 U 471 SER GLY LYS ILE THR LYS LEU GLY ARG SER PHE ALA ARG
SEQRES 17 U 471 SER ARG ASP TYR ASP ALA MET GLY ALA ASP THR ARG PHE
SEQRES 18 U 471 VAL GLN CYS PRO GLU GLY GLU LEU GLN LYS ARG LYS THR
SEQRES 19 U 471 VAL VAL HIS THR VAL SER LEU HIS GLU ILE ASP VAL ILE
SEQRES 20 U 471 ASN SER ARG THR GLN GLY PHE LEU ALA LEU PHE THR GLY
SEQRES 21 U 471 ASP THR GLY GLU ILE ARG SER GLU VAL ARG ASP GLN ILE
SEQRES 22 U 471 ASN THR LYS VAL ALA GLU TRP LYS GLU GLU GLY LYS ALA
SEQRES 23 U 471 GLU ILE VAL PRO GLY VAL LEU PHE ILE ASP GLU VAL HIS
SEQRES 24 U 471 MET LEU ASP ILE GLU CYS PHE SER PHE ILE ASN ARG ALA
SEQRES 25 U 471 LEU GLU ASP GLU PHE ALA PRO ILE VAL MET MET ALA THR
SEQRES 26 U 471 ASN ARG GLY VAL SER LYS THR ARG GLY THR ASN TYR LYS
SEQRES 27 U 471 SER PRO HIS GLY LEU PRO LEU ASP LEU LEU ASP ARG SER
SEQRES 28 U 471 ILE ILE ILE THR THR LYS SER TYR ASN GLU GLN GLU ILE
SEQRES 29 U 471 LYS THR ILE LEU SER ILE ARG ALA GLN GLU GLU GLU VAL
SEQRES 30 U 471 GLU LEU SER SER ASP ALA LEU ASP LEU LEU THR LYS THR
SEQRES 31 U 471 GLY VAL GLU THR SER LEU ARG TYR SER SER ASN LEU ILE
SEQRES 32 U 471 SER VAL ALA GLN GLN ILE ALA MET LYS ARG LYS ASN ASN
SEQRES 33 U 471 THR VAL GLU VAL GLU ASP VAL LYS ARG ALA TYR LEU LEU
SEQRES 34 U 471 PHE LEU ASP SER ALA ARG SER VAL LYS TYR VAL GLN GLU
SEQRES 35 U 471 ASN GLU SER GLN TYR ILE ASP ASP GLN GLY ASN VAL GLN
SEQRES 36 U 471 ILE SER ILE ALA LYS SER ALA ASP PRO ASP ALA MET ASP
SEQRES 37 U 471 THR THR GLU
SEQRES 1 V 463 MET VAL ALA ILE SER GLU VAL LYS GLU ASN PRO GLY VAL
SEQRES 2 V 463 ASN SER SER ASN SER GLY ALA VAL THR ARG THR ALA ALA
SEQRES 3 V 463 HIS THR HIS ILE LYS GLY LEU GLY LEU ASP GLU SER GLY
SEQRES 4 V 463 VAL ALA LYS ARG VAL GLU GLY GLY PHE VAL GLY GLN ILE
SEQRES 5 V 463 GLU ALA ARG GLU ALA CYS GLY VAL ILE VAL ASP LEU ILE
SEQRES 6 V 463 LYS ALA LYS LYS MET SER GLY ARG ALA ILE LEU LEU ALA
SEQRES 7 V 463 GLY GLY PRO SER THR GLY LYS THR ALA LEU ALA LEU ALA
SEQRES 8 V 463 ILE SER GLN GLU LEU GLY PRO LYS VAL PRO PHE CYS PRO
SEQRES 9 V 463 LEU VAL GLY SER GLU LEU TYR SER VAL GLU VAL LYS LYS
SEQRES 10 V 463 THR GLU THR LEU MET GLU ASN PHE ARG ARG ALA ILE GLY
SEQRES 11 V 463 LEU ARG ILE LYS GLU THR LYS GLU VAL TYR GLU GLY GLU
SEQRES 12 V 463 VAL THR GLU LEU THR PRO GLU ASP ALA GLU ASN PRO LEU
SEQRES 13 V 463 GLY GLY TYR GLY LYS THR ILE SER HIS VAL ILE VAL GLY
SEQRES 14 V 463 LEU LYS SER ALA LYS GLY THR LYS THR LEU ARG LEU ASP
SEQRES 15 V 463 PRO THR ILE TYR GLU SER ILE GLN ARG GLU LYS VAL SER
SEQRES 16 V 463 ILE GLY ASP VAL ILE TYR ILE GLU ALA ASN THR GLY ALA
SEQRES 17 V 463 VAL LYS ARG VAL GLY ARG SER ASP ALA TYR ALA THR GLU
SEQRES 18 V 463 PHE ASP LEU GLU THR GLU GLU TYR VAL PRO LEU PRO LYS
SEQRES 19 V 463 GLY GLU VAL HIS LYS LYS LYS GLU ILE VAL GLN ASP VAL
SEQRES 20 V 463 THR LEU HIS ASP LEU ASP VAL ALA ASN ALA ARG PRO GLN
SEQRES 21 V 463 GLY GLY GLN ASP VAL ILE SER MET MET GLY GLN LEU LEU
SEQRES 22 V 463 LYS PRO LYS LYS THR GLU ILE THR GLU LYS LEU ARG GLN
SEQRES 23 V 463 GLU VAL ASN LYS VAL VAL ALA LYS TYR ILE ASP GLN GLY
SEQRES 24 V 463 VAL ALA GLU LEU ILE PRO GLY VAL LEU PHE ILE ASP GLU
SEQRES 25 V 463 VAL ASN MET LEU ASP ILE GLU ILE PHE THR TYR LEU ASN
SEQRES 26 V 463 LYS ALA LEU GLU SER ASN ILE ALA PRO VAL VAL VAL LEU
SEQRES 27 V 463 ALA SER ASN ARG GLY MET THR THR VAL ARG GLY THR GLU
SEQRES 28 V 463 ASP VAL ILE SER PRO HIS GLY VAL PRO PRO ASP LEU ILE
SEQRES 29 V 463 ASP ARG LEU LEU ILE VAL ARG THR LEU PRO TYR ASP LYS
SEQRES 30 V 463 ASP GLU ILE ARG THR ILE ILE GLU ARG ARG ALA THR VAL
SEQRES 31 V 463 GLU ARG LEU GLN VAL GLU SER SER ALA LEU ASP LEU LEU
SEQRES 32 V 463 ALA THR MET GLY THR GLU THR SER LEU ARG TYR ALA LEU
SEQRES 33 V 463 GLN LEU LEU ALA PRO CYS GLY ILE LEU ALA GLN THR SER
SEQRES 34 V 463 ASN ARG LYS GLU ILE VAL VAL ASN ASP VAL ASN GLU ALA
SEQRES 35 V 463 LYS LEU LEU PHE LEU ASP ALA LYS ARG SER THR LYS ILE
SEQRES 36 V 463 LEU GLU THR SER ALA ASN TYR LEU
SEQRES 1 W 471 MET SER ILE GLN THR SER ASP PRO ASN GLU THR SER ASP
SEQRES 2 W 471 LEU LYS SER LEU SER LEU ILE ALA ALA HIS SER HIS ILE
SEQRES 3 W 471 THR GLY LEU GLY LEU ASP GLU ASN LEU GLN PRO ARG PRO
SEQRES 4 W 471 THR SER GLU GLY MET VAL GLY GLN LEU GLN ALA ARG ARG
SEQRES 5 W 471 ALA ALA GLY VAL ILE LEU LYS MET VAL GLN ASN GLY THR
SEQRES 6 W 471 ILE ALA GLY ARG ALA VAL LEU VAL ALA GLY PRO PRO SER
SEQRES 7 W 471 THR GLY LYS THR ALA LEU ALA MET GLY VAL SER GLN SER
SEQRES 8 W 471 LEU GLY LYS ASP VAL PRO PHE THR ALA ILE ALA GLY SER
SEQRES 9 W 471 GLU ILE PHE SER LEU GLU LEU SER LYS THR GLU ALA LEU
SEQRES 10 W 471 THR GLN ALA PHE ARG LYS SER ILE GLY ILE LYS ILE LYS
SEQRES 11 W 471 GLU GLU THR GLU LEU ILE GLU GLY GLU VAL VAL GLU ILE
SEQRES 12 W 471 GLN ILE ASP ARG SER ILE THR GLY GLY HIS LYS GLN GLY
SEQRES 13 W 471 LYS LEU THR ILE LYS THR THR ASP MET GLU THR ILE TYR
SEQRES 14 W 471 GLU LEU GLY ASN LYS MET ILE ASP GLY LEU THR LYS GLU
SEQRES 15 W 471 LYS VAL LEU ALA GLY ASP VAL ILE SER ILE ASP LYS ALA
SEQRES 16 W 471 SER GLY LYS ILE THR LYS LEU GLY ARG SER PHE ALA ARG
SEQRES 17 W 471 SER ARG ASP TYR ASP ALA MET GLY ALA ASP THR ARG PHE
SEQRES 18 W 471 VAL GLN CYS PRO GLU GLY GLU LEU GLN LYS ARG LYS THR
SEQRES 19 W 471 VAL VAL HIS THR VAL SER LEU HIS GLU ILE ASP VAL ILE
SEQRES 20 W 471 ASN SER ARG THR GLN GLY PHE LEU ALA LEU PHE THR GLY
SEQRES 21 W 471 ASP THR GLY GLU ILE ARG SER GLU VAL ARG ASP GLN ILE
SEQRES 22 W 471 ASN THR LYS VAL ALA GLU TRP LYS GLU GLU GLY LYS ALA
SEQRES 23 W 471 GLU ILE VAL PRO GLY VAL LEU PHE ILE ASP GLU VAL HIS
SEQRES 24 W 471 MET LEU ASP ILE GLU CYS PHE SER PHE ILE ASN ARG ALA
SEQRES 25 W 471 LEU GLU ASP GLU PHE ALA PRO ILE VAL MET MET ALA THR
SEQRES 26 W 471 ASN ARG GLY VAL SER LYS THR ARG GLY THR ASN TYR LYS
SEQRES 27 W 471 SER PRO HIS GLY LEU PRO LEU ASP LEU LEU ASP ARG SER
SEQRES 28 W 471 ILE ILE ILE THR THR LYS SER TYR ASN GLU GLN GLU ILE
SEQRES 29 W 471 LYS THR ILE LEU SER ILE ARG ALA GLN GLU GLU GLU VAL
SEQRES 30 W 471 GLU LEU SER SER ASP ALA LEU ASP LEU LEU THR LYS THR
SEQRES 31 W 471 GLY VAL GLU THR SER LEU ARG TYR SER SER ASN LEU ILE
SEQRES 32 W 471 SER VAL ALA GLN GLN ILE ALA MET LYS ARG LYS ASN ASN
SEQRES 33 W 471 THR VAL GLU VAL GLU ASP VAL LYS ARG ALA TYR LEU LEU
SEQRES 34 W 471 PHE LEU ASP SER ALA ARG SER VAL LYS TYR VAL GLN GLU
SEQRES 35 W 471 ASN GLU SER GLN TYR ILE ASP ASP GLN GLY ASN VAL GLN
SEQRES 36 W 471 ILE SER ILE ALA LYS SER ALA ASP PRO ASP ALA MET ASP
SEQRES 37 W 471 THR THR GLU
SEQRES 1 X 463 MET VAL ALA ILE SER GLU VAL LYS GLU ASN PRO GLY VAL
SEQRES 2 X 463 ASN SER SER ASN SER GLY ALA VAL THR ARG THR ALA ALA
SEQRES 3 X 463 HIS THR HIS ILE LYS GLY LEU GLY LEU ASP GLU SER GLY
SEQRES 4 X 463 VAL ALA LYS ARG VAL GLU GLY GLY PHE VAL GLY GLN ILE
SEQRES 5 X 463 GLU ALA ARG GLU ALA CYS GLY VAL ILE VAL ASP LEU ILE
SEQRES 6 X 463 LYS ALA LYS LYS MET SER GLY ARG ALA ILE LEU LEU ALA
SEQRES 7 X 463 GLY GLY PRO SER THR GLY LYS THR ALA LEU ALA LEU ALA
SEQRES 8 X 463 ILE SER GLN GLU LEU GLY PRO LYS VAL PRO PHE CYS PRO
SEQRES 9 X 463 LEU VAL GLY SER GLU LEU TYR SER VAL GLU VAL LYS LYS
SEQRES 10 X 463 THR GLU THR LEU MET GLU ASN PHE ARG ARG ALA ILE GLY
SEQRES 11 X 463 LEU ARG ILE LYS GLU THR LYS GLU VAL TYR GLU GLY GLU
SEQRES 12 X 463 VAL THR GLU LEU THR PRO GLU ASP ALA GLU ASN PRO LEU
SEQRES 13 X 463 GLY GLY TYR GLY LYS THR ILE SER HIS VAL ILE VAL GLY
SEQRES 14 X 463 LEU LYS SER ALA LYS GLY THR LYS THR LEU ARG LEU ASP
SEQRES 15 X 463 PRO THR ILE TYR GLU SER ILE GLN ARG GLU LYS VAL SER
SEQRES 16 X 463 ILE GLY ASP VAL ILE TYR ILE GLU ALA ASN THR GLY ALA
SEQRES 17 X 463 VAL LYS ARG VAL GLY ARG SER ASP ALA TYR ALA THR GLU
SEQRES 18 X 463 PHE ASP LEU GLU THR GLU GLU TYR VAL PRO LEU PRO LYS
SEQRES 19 X 463 GLY GLU VAL HIS LYS LYS LYS GLU ILE VAL GLN ASP VAL
SEQRES 20 X 463 THR LEU HIS ASP LEU ASP VAL ALA ASN ALA ARG PRO GLN
SEQRES 21 X 463 GLY GLY GLN ASP VAL ILE SER MET MET GLY GLN LEU LEU
SEQRES 22 X 463 LYS PRO LYS LYS THR GLU ILE THR GLU LYS LEU ARG GLN
SEQRES 23 X 463 GLU VAL ASN LYS VAL VAL ALA LYS TYR ILE ASP GLN GLY
SEQRES 24 X 463 VAL ALA GLU LEU ILE PRO GLY VAL LEU PHE ILE ASP GLU
SEQRES 25 X 463 VAL ASN MET LEU ASP ILE GLU ILE PHE THR TYR LEU ASN
SEQRES 26 X 463 LYS ALA LEU GLU SER ASN ILE ALA PRO VAL VAL VAL LEU
SEQRES 27 X 463 ALA SER ASN ARG GLY MET THR THR VAL ARG GLY THR GLU
SEQRES 28 X 463 ASP VAL ILE SER PRO HIS GLY VAL PRO PRO ASP LEU ILE
SEQRES 29 X 463 ASP ARG LEU LEU ILE VAL ARG THR LEU PRO TYR ASP LYS
SEQRES 30 X 463 ASP GLU ILE ARG THR ILE ILE GLU ARG ARG ALA THR VAL
SEQRES 31 X 463 GLU ARG LEU GLN VAL GLU SER SER ALA LEU ASP LEU LEU
SEQRES 32 X 463 ALA THR MET GLY THR GLU THR SER LEU ARG TYR ALA LEU
SEQRES 33 X 463 GLN LEU LEU ALA PRO CYS GLY ILE LEU ALA GLN THR SER
SEQRES 34 X 463 ASN ARG LYS GLU ILE VAL VAL ASN ASP VAL ASN GLU ALA
SEQRES 35 X 463 LYS LEU LEU PHE LEU ASP ALA LYS ARG SER THR LYS ILE
SEQRES 36 X 463 LEU GLU THR SER ALA ASN TYR LEU
SEQRES 1 Y 471 MET SER ILE GLN THR SER ASP PRO ASN GLU THR SER ASP
SEQRES 2 Y 471 LEU LYS SER LEU SER LEU ILE ALA ALA HIS SER HIS ILE
SEQRES 3 Y 471 THR GLY LEU GLY LEU ASP GLU ASN LEU GLN PRO ARG PRO
SEQRES 4 Y 471 THR SER GLU GLY MET VAL GLY GLN LEU GLN ALA ARG ARG
SEQRES 5 Y 471 ALA ALA GLY VAL ILE LEU LYS MET VAL GLN ASN GLY THR
SEQRES 6 Y 471 ILE ALA GLY ARG ALA VAL LEU VAL ALA GLY PRO PRO SER
SEQRES 7 Y 471 THR GLY LYS THR ALA LEU ALA MET GLY VAL SER GLN SER
SEQRES 8 Y 471 LEU GLY LYS ASP VAL PRO PHE THR ALA ILE ALA GLY SER
SEQRES 9 Y 471 GLU ILE PHE SER LEU GLU LEU SER LYS THR GLU ALA LEU
SEQRES 10 Y 471 THR GLN ALA PHE ARG LYS SER ILE GLY ILE LYS ILE LYS
SEQRES 11 Y 471 GLU GLU THR GLU LEU ILE GLU GLY GLU VAL VAL GLU ILE
SEQRES 12 Y 471 GLN ILE ASP ARG SER ILE THR GLY GLY HIS LYS GLN GLY
SEQRES 13 Y 471 LYS LEU THR ILE LYS THR THR ASP MET GLU THR ILE TYR
SEQRES 14 Y 471 GLU LEU GLY ASN LYS MET ILE ASP GLY LEU THR LYS GLU
SEQRES 15 Y 471 LYS VAL LEU ALA GLY ASP VAL ILE SER ILE ASP LYS ALA
SEQRES 16 Y 471 SER GLY LYS ILE THR LYS LEU GLY ARG SER PHE ALA ARG
SEQRES 17 Y 471 SER ARG ASP TYR ASP ALA MET GLY ALA ASP THR ARG PHE
SEQRES 18 Y 471 VAL GLN CYS PRO GLU GLY GLU LEU GLN LYS ARG LYS THR
SEQRES 19 Y 471 VAL VAL HIS THR VAL SER LEU HIS GLU ILE ASP VAL ILE
SEQRES 20 Y 471 ASN SER ARG THR GLN GLY PHE LEU ALA LEU PHE THR GLY
SEQRES 21 Y 471 ASP THR GLY GLU ILE ARG SER GLU VAL ARG ASP GLN ILE
SEQRES 22 Y 471 ASN THR LYS VAL ALA GLU TRP LYS GLU GLU GLY LYS ALA
SEQRES 23 Y 471 GLU ILE VAL PRO GLY VAL LEU PHE ILE ASP GLU VAL HIS
SEQRES 24 Y 471 MET LEU ASP ILE GLU CYS PHE SER PHE ILE ASN ARG ALA
SEQRES 25 Y 471 LEU GLU ASP GLU PHE ALA PRO ILE VAL MET MET ALA THR
SEQRES 26 Y 471 ASN ARG GLY VAL SER LYS THR ARG GLY THR ASN TYR LYS
SEQRES 27 Y 471 SER PRO HIS GLY LEU PRO LEU ASP LEU LEU ASP ARG SER
SEQRES 28 Y 471 ILE ILE ILE THR THR LYS SER TYR ASN GLU GLN GLU ILE
SEQRES 29 Y 471 LYS THR ILE LEU SER ILE ARG ALA GLN GLU GLU GLU VAL
SEQRES 30 Y 471 GLU LEU SER SER ASP ALA LEU ASP LEU LEU THR LYS THR
SEQRES 31 Y 471 GLY VAL GLU THR SER LEU ARG TYR SER SER ASN LEU ILE
SEQRES 32 Y 471 SER VAL ALA GLN GLN ILE ALA MET LYS ARG LYS ASN ASN
SEQRES 33 Y 471 THR VAL GLU VAL GLU ASP VAL LYS ARG ALA TYR LEU LEU
SEQRES 34 Y 471 PHE LEU ASP SER ALA ARG SER VAL LYS TYR VAL GLN GLU
SEQRES 35 Y 471 ASN GLU SER GLN TYR ILE ASP ASP GLN GLY ASN VAL GLN
SEQRES 36 Y 471 ILE SER ILE ALA LYS SER ALA ASP PRO ASP ALA MET ASP
SEQRES 37 Y 471 THR THR GLU
HET ADP M1601 27
HET BEF M1602 4
HET MG M1603 1
HET ADP R 501 27
HET BEF R 502 4
HET MG R 503 1
HET ZN S 501 1
HET ZN S 502 1
HET ADP T 501 27
HET MG U 501 1
HET ADP U 502 27
HET MG U 503 1
HET ADP V 501 27
HET MG V 502 1
HET ADP W 501 27
HET MG W 502 1
HET ADP X 501 27
HET MG X 502 1
HET ADP Y 501 27
HET MG Y 502 1
HETNAM ADP ADENOSINE-5'-DIPHOSPHATE
HETNAM BEF BERYLLIUM TRIFLUORIDE ION
HETNAM MG MAGNESIUM ION
HETNAM ZN ZINC ION
FORMUL 21 ADP 8(C10 H15 N5 O10 P2)
FORMUL 22 BEF 2(BE F3 1-)
FORMUL 23 MG 8(MG 2+)
FORMUL 27 ZN 2(ZN 2+)
HELIX 1 AA1 UNK Z 101 UNK Z 129 1 29
HELIX 2 AA2 UNK Z 136 UNK Z 144 1 9
HELIX 3 AA3 UNK Z 198 UNK Z 200 5 3
HELIX 4 AA4 UNK Z 201 UNK Z 207 1 7
HELIX 5 AA5 GLY A 44 LYS A 56 1 13
HELIX 6 AA6 ARG A 63 ASP A 77 1 15
HELIX 7 AA7 ALA A 88 ALA A 114 1 27
HELIX 8 AA8 GLN A 120 LEU A 130 1 11
HELIX 9 AA9 GLY B 44 LYS B 56 1 13
HELIX 10 AB1 ARG B 63 ASP B 77 1 15
HELIX 11 AB2 ALA B 88 ALA B 114 1 27
HELIX 12 AB3 GLN B 120 LEU B 130 1 11
HELIX 13 AB4 ASN C 25 ILE C 29 5 5
HELIX 14 AB5 THR C 30 GLY C 41 1 12
HELIX 15 AB6 LEU C 49 ALA C 76 1 28
HELIX 16 AB7 THR C 82 ARG C 92 1 11
HELIX 17 AB8 ASN D 25 ILE D 29 5 5
HELIX 18 AB9 THR D 30 GLY D 41 1 12
HELIX 19 AC1 LEU D 49 ALA D 76 1 28
HELIX 20 AC2 THR D 82 ARG D 92 1 11
HELIX 21 AC3 SER E 17 ALA E 22 1 6
HELIX 22 AC4 PRO E 27 GLY E 38 1 12
HELIX 23 AC5 GLY E 47 ASN E 74 1 28
HELIX 24 AC6 ILE E 80 ASP E 91 1 12
HELIX 25 AC7 ASP E 91 LEU E 98 1 8
HELIX 26 AC8 ARG F 18 ALA F 22 1 5
HELIX 27 AC9 PRO F 27 GLY F 38 1 12
HELIX 28 AD1 GLY F 47 ASN F 74 1 28
HELIX 29 AD2 ILE F 80 ASP F 91 1 12
HELIX 30 AD3 ASP F 91 LEU F 98 1 8
HELIX 31 AD4 TYR G 40 HIS G 52 1 13
HELIX 32 AD5 SER G 58 ASN G 87 1 30
HELIX 33 AD6 SER G 93 LEU G 105 1 13
HELIX 34 AD7 PRO G 106 SER G 126 1 21
HELIX 35 AD8 TYR H 40 HIS H 52 1 13
HELIX 36 AD9 SER H 58 ASN H 87 1 30
HELIX 37 AE1 SER H 93 LEU H 105 1 13
HELIX 38 AE2 PRO H 106 SER H 125 1 20
HELIX 39 AE3 ARG M 697 ASN M 712 1 16
HELIX 40 AE4 GLY M 726 LYS M 742 1 17
HELIX 41 AE5 VAL M 756 PHE M 767 1 12
HELIX 42 AE6 GLN M 781 ARG M 787 1 7
HELIX 43 AE7 GLN M 804 ASP M 809 1 6
HELIX 44 AE8 ASP M 809 LYS M 814 1 6
HELIX 45 AE9 SER M 834 ASN M 842 1 9
HELIX 46 AF1 ASN M 859 MET M 871 1 13
HELIX 47 AF2 THR M 914 LEU M 925 1 12
HELIX 48 AF3 SER M 954 LYS M 971 1 18
HELIX 49 AF4 ALA M 972 ALA M 975 5 4
HELIX 50 AF5 ASN M 978 ASN M 994 1 17
HELIX 51 AF6 CYS M 1013 LYS M 1030 1 18
HELIX 52 AF7 VAL M 1046 ASN M 1050 5 5
HELIX 53 AF8 SER M 1056 LEU M 1065 1 10
HELIX 54 AF9 LYS M 1069 PHE M 1094 1 26
HELIX 55 AG1 TYR M 1103 ARG M 1133 1 31
HELIX 56 AG2 ILE M 1141 ASP M 1147 1 7
HELIX 57 AG3 ASP M 1159 LYS M 1164 1 6
HELIX 58 AG4 PRO M 1165 ASN M 1173 1 9
HELIX 59 AG5 ASN M 1173 ALA M 1181 1 9
HELIX 60 AG6 ASP M 1191 GLY M 1198 1 8
HELIX 61 AG7 GLY M 1206 VAL M 1220 1 15
HELIX 62 AG8 LEU M 1224 ILE M 1233 1 10
HELIX 63 AG9 SER M 1239 ASP M 1244 1 6
HELIX 64 AH1 LYS M 1250 ASN M 1261 1 12
HELIX 65 AH2 THR M 1272 GLY M 1286 1 15
HELIX 66 AH3 ILE M 1298 THR M 1310 1 13
HELIX 67 AH4 ASP M 1348 HIS M 1356 1 9
HELIX 68 AH5 THR M 1374 LYS M 1386 1 13
HELIX 69 AH6 SER R 43 ILE R 49 5 7
HELIX 70 AH7 LEU R 68 ASN R 82 1 15
HELIX 71 AH8 LEU R 108 GLU R 122 1 15
HELIX 72 AH9 PRO R 132 VAL R 137 1 6
HELIX 73 AI1 PRO R 138 TYR R 143 5 6
HELIX 74 AI2 GLY R 219 HIS R 235 1 17
HELIX 75 AI3 GLU R 241 LEU R 253 1 13
HELIX 76 AI4 SER R 259 THR R 266 1 8
HELIX 77 AI5 THR R 307 ILE R 313 1 7
HELIX 78 AI6 PRO R 314 PHE R 317 5 4
HELIX 79 AI7 HIS R 319 GLN R 324 5 6
HELIX 80 AI8 GLY R 329 MET R 340 1 12
HELIX 81 AI9 VAL R 345 VAL R 350 1 6
HELIX 82 AJ1 GLY R 358 LEU R 362 5 5
HELIX 83 AJ2 ASN R 364 LEU R 377 1 14
HELIX 84 AJ3 ASP R 391 THR R 406 1 16
HELIX 85 AJ4 ASP R 407 ARG R 413 1 7
HELIX 86 AJ5 THR R 415 HIS R 422 1 8
HELIX 87 AJ6 GLY R 423 HIS R 430 1 8
HELIX 88 AJ7 SER S 52 TYR S 61 1 10
HELIX 89 AJ8 THR S 91 THR S 107 1 17
HELIX 90 AJ9 ASN S 115 GLY S 125 1 11
HELIX 91 AK1 PRO S 127 THR S 135 1 9
HELIX 92 AK2 LYS S 168 TYR S 179 1 12
HELIX 93 AK3 LYS S 180 THR S 182 5 3
HELIX 94 AK4 THR S 192 SER S 203 1 12
HELIX 95 AK5 ASN S 207 SER S 214 1 8
HELIX 96 AK6 ASN S 218 TYR S 226 1 9
HELIX 97 AK7 SER S 265 ASN S 273 1 9
HELIX 98 AK8 GLN T 51 LYS T 68 1 18
HELIX 99 AK9 GLY T 84 GLY T 97 1 14
HELIX 100 AL1 SER T 108 LEU T 110 5 3
HELIX 101 AL2 LYS T 116 ILE T 129 1 14
HELIX 102 AL3 ASP T 182 LYS T 193 1 12
HELIX 103 AL4 ALA T 217 PHE T 222 5 6
HELIX 104 AL5 LEU T 249 ARG T 258 1 10
HELIX 105 AL6 ASP T 264 LEU T 273 1 10
HELIX 106 AL7 THR T 281 ILE T 296 1 16
HELIX 107 AL8 VAL T 313 LEU T 316 5 4
HELIX 108 AL9 ASP T 317 GLU T 329 1 13
HELIX 109 AM1 PRO T 356 VAL T 359 5 4
HELIX 110 AM2 PRO T 360 LEU T 367 1 8
HELIX 111 AM3 ASP T 376 ARG T 392 1 17
HELIX 112 AM4 GLU T 396 THR T 410 1 15
HELIX 113 AM5 SER T 411 SER T 429 1 19
HELIX 114 AM6 VAL T 435 PHE T 446 1 12
HELIX 115 AM7 ASP T 448 THR T 458 1 11
HELIX 116 AM8 GLN U 47 GLY U 64 1 18
HELIX 117 AM9 LYS U 81 GLY U 93 1 13
HELIX 118 AN1 SER U 112 SER U 124 1 13
HELIX 119 AN2 ASN U 173 GLU U 182 1 10
HELIX 120 AN3 LEU U 241 ARG U 250 1 10
HELIX 121 AN4 GLY U 253 GLY U 260 1 8
HELIX 122 AN5 ARG U 266 GLU U 283 1 18
HELIX 123 AN6 VAL U 298 LEU U 301 5 4
HELIX 124 AN7 ASP U 302 GLU U 314 1 13
HELIX 125 AN8 PRO U 340 LEU U 343 5 4
HELIX 126 AN9 PRO U 344 ARG U 350 1 7
HELIX 127 AO1 ASN U 360 GLU U 375 1 16
HELIX 128 AO2 SER U 380 THR U 394 1 15
HELIX 129 AO3 SER U 395 ARG U 413 1 19
HELIX 130 AO4 GLU U 419 PHE U 430 1 12
HELIX 131 AO5 ASP U 432 GLU U 444 1 13
HELIX 132 AO6 GLN V 51 LYS V 68 1 18
HELIX 133 AO7 GLY V 84 GLY V 97 1 14
HELIX 134 AO8 SER V 108 TYR V 111 5 4
HELIX 135 AO9 LYS V 116 ALA V 128 1 13
HELIX 136 AP1 ASP V 182 GLU V 192 1 11
HELIX 137 AP2 ALA V 217 ALA V 219 5 3
HELIX 138 AP3 LEU V 249 ARG V 258 1 10
HELIX 139 AP4 ASP V 264 LYS V 274 1 11
HELIX 140 AP5 THR V 281 GLN V 298 1 18
HELIX 141 AP6 VAL V 313 LEU V 316 5 4
HELIX 142 AP7 ASP V 317 LEU V 328 1 12
HELIX 143 AP8 PRO V 360 ARG V 366 1 7
HELIX 144 AP9 ASP V 376 GLU V 391 1 16
HELIX 145 AQ1 GLU V 396 THR V 410 1 15
HELIX 146 AQ2 SER V 411 LEU V 418 1 8
HELIX 147 AQ3 LEU V 418 SER V 429 1 12
HELIX 148 AQ4 VAL V 435 PHE V 446 1 12
HELIX 149 AQ5 ASP V 448 THR V 458 1 11
HELIX 150 AQ6 GLN W 47 GLY W 64 1 18
HELIX 151 AQ7 GLY W 80 GLY W 93 1 14
HELIX 152 AQ8 SER W 112 ILE W 125 1 14
HELIX 153 AQ9 GLY W 172 GLU W 182 1 11
HELIX 154 AR1 LEU W 241 ASN W 248 1 8
HELIX 155 AR2 THR W 251 GLY W 253 5 3
HELIX 156 AR3 PHE W 254 GLY W 260 1 7
HELIX 157 AR4 ARG W 266 GLU W 283 1 18
HELIX 158 AR5 ASP W 302 LEU W 313 1 12
HELIX 159 AR6 PRO W 340 LEU W 343 5 4
HELIX 160 AR7 PRO W 344 ARG W 350 1 7
HELIX 161 AR8 ASN W 360 GLU W 376 1 17
HELIX 162 AR9 SER W 380 THR W 394 1 15
HELIX 163 AS1 SER W 395 LYS W 412 1 18
HELIX 164 AS2 GLU W 419 PHE W 430 1 12
HELIX 165 AS3 ASP W 432 ASN W 443 1 12
HELIX 166 AS4 GLN X 51 LYS X 68 1 18
HELIX 167 AS5 GLY X 84 GLY X 97 1 14
HELIX 168 AS6 SER X 108 TYR X 111 5 4
HELIX 169 AS7 LYS X 116 ARG X 127 1 12
HELIX 170 AS8 THR X 184 LYS X 193 1 10
HELIX 171 AS9 ALA X 217 ALA X 219 5 3
HELIX 172 AT1 LEU X 249 ARG X 258 1 10
HELIX 173 AT2 ASP X 264 GLN X 271 1 8
HELIX 174 AT3 THR X 281 GLN X 298 1 18
HELIX 175 AT4 GLU X 312 LEU X 316 5 5
HELIX 176 AT5 ASP X 317 LEU X 328 1 12
HELIX 177 AT6 PRO X 356 VAL X 359 5 4
HELIX 178 AT7 PRO X 360 ASP X 365 1 6
HELIX 179 AT8 ASP X 376 ARG X 392 1 17
HELIX 180 AT9 SER X 397 THR X 410 1 14
HELIX 181 AU1 SER X 411 LEU X 418 1 8
HELIX 182 AU2 LEU X 418 SER X 429 1 12
HELIX 183 AU3 VAL X 435 PHE X 446 1 12
HELIX 184 AU4 ASP X 448 THR X 458 1 11
HELIX 185 AU5 GLN Y 47 GLY Y 64 1 18
HELIX 186 AU6 LYS Y 81 GLY Y 93 1 13
HELIX 187 AU7 SER Y 112 LYS Y 123 1 12
HELIX 188 AU8 GLY Y 172 LYS Y 181 1 10
HELIX 189 AU9 PHE Y 206 SER Y 209 5 4
HELIX 190 AV1 LEU Y 241 ARG Y 250 1 10
HELIX 191 AV2 GLY Y 253 GLY Y 260 1 8
HELIX 192 AV3 ARG Y 266 GLU Y 283 1 18
HELIX 193 AV4 ASP Y 302 LEU Y 313 1 12
HELIX 194 AV5 PRO Y 340 LEU Y 343 5 4
HELIX 195 AV6 PRO Y 344 ARG Y 350 1 7
HELIX 196 AV7 ASN Y 360 GLU Y 376 1 17
HELIX 197 AV8 ASP Y 382 THR Y 394 1 13
HELIX 198 AV9 SER Y 395 ARG Y 413 1 19
HELIX 199 AW1 GLU Y 419 PHE Y 430 1 12
HELIX 200 AW2 ASP Y 432 ASN Y 443 1 12
SHEET 1 A 2 UNK Z 169 UNK Z 171 0
SHEET 2 A 2 UNK Z 176 UNK Z 178 -1 N UNK Z 177 O UNK Z 170
SHEET 1 B 2 LEU M 719 ASP M 721 0
SHEET 2 B 2 LEU M 930 ARG M 932 1 N LEU M 930 O ALA M 720
SHEET 1 C 4 ILE M 800 SER M 802 0
SHEET 2 C 4 LEU M 749 VAL M 752 1 N ILE M 750 O VAL M 801
SHEET 3 C 4 TYR M 820 ASP M 824 1 N VAL M 822 O LEU M 749
SHEET 4 C 4 ARG M 847 LEU M 851 1 N ARG M 847 O MET M 821
SHEET 1 D 2 LYS M 944 GLU M 946 0
SHEET 2 D 2 VAL M1364 ILE M1366 1 N VAL M1364 O TYR M 945
SHEET 1 E 2 VAL M 949 CYS M 951 0
SHEET 2 E 2 PHE M1369 SER M1371 1 N VAL M1370 O VAL M 949
SHEET 1 F 4 THR M1335 PHE M1338 0
SHEET 2 F 4 ALA M1265 THR M1269 1 N LEU M1266 O THR M1335
SHEET 3 F 4 VAL M1316 SER M1320 1 N PHE M1317 O ALA M1265
SHEET 4 F 4 TYR M1289 ARG M1291 1 N MET M1290 O VAL M1316
SHEET 1 G 5 SER R 127 LYS R 130 0
SHEET 2 G 5 HIS R 98 SER R 102 1 N LEU R 99 O SER R 127
SHEET 3 G 5 ILE R 6 ASP R 9 1 N ILE R 6 O VAL R 100
SHEET 4 G 5 GLU R 14 PRO R 19 -1 N GLY R 18 O VAL R 7
SHEET 5 G 5 PHE R 26 LEU R 29 -1 N ALA R 28 O ILE R 15
SHEET 1 H 2 LEU R 32 ASP R 35 0
SHEET 2 H 2 ILE R 55 ARG R 58 -1 N ARG R 58 O LEU R 32
SHEET 1 I 2 MET R 147 SER R 151 0
SHEET 2 I 2 HIS R 384 PRO R 388 -1 N VAL R 387 O ARG R 148
SHEET 1 J 4 ILE R 353 THR R 356 0
SHEET 2 J 4 GLN R 188 ASP R 192 1 N LEU R 189 O VAL R 354
SHEET 3 J 4 THR R 198 VAL R 203 -1 N VAL R 203 O GLN R 188
SHEET 4 J 4 LYS R 214 LEU R 216 -1 N LEU R 216 O THR R 198
SHEET 1 K 3 TYR R 286 ASN R 289 0
SHEET 2 K 3 LEU R 272 VAL R 275 -1 N VAL R 275 O TYR R 286
SHEET 3 K 3 ILE R 303 LEU R 306 -1 N LEU R 306 O LEU R 272
SHEET 1 L 5 ILE T 369 THR T 372 0
SHEET 2 L 5 ALA T 74 GLY T 79 1 N LEU T 76 O VAL T 370
SHEET 3 L 5 VAL T 335 SER T 340 1 N VAL T 336 O ILE T 75
SHEET 4 L 5 VAL T 307 ASP T 311 1 N LEU T 308 O VAL T 335
SHEET 5 L 5 PHE T 102 VAL T 106 1 N CYS T 103 O VAL T 307
SHEET 1 M 3 ASP T 246 THR T 248 0
SHEET 2 M 3 GLY T 130 ILE T 133 -1 N LEU T 131 O VAL T 247
SHEET 3 M 3 ALA T 301 ILE T 304 -1 N ILE T 304 O GLY T 130
SHEET 1 N 4 HIS T 238 ILE T 243 0
SHEET 2 N 4 GLU T 135 GLU T 143 -1 N VAL T 139 O LYS T 239
SHEET 3 N 4 ASP T 198 GLU T 203 -1 N ILE T 202 O TYR T 140
SHEET 4 N 4 VAL T 209 ARG T 214 -1 N GLY T 213 O VAL T 199
SHEET 1 O 3 LEU T 147 GLU T 150 0
SHEET 2 O 3 HIS T 165 LYS T 171 -1 N ILE T 167 O THR T 148
SHEET 3 O 3 THR T 176 LEU T 181 -1 N LEU T 181 O VAL T 166
SHEET 1 P 5 SER U 351 THR U 355 0
SHEET 2 P 5 ALA U 70 ALA U 74 1 N ALA U 70 O ILE U 352
SHEET 3 P 5 ILE U 320 THR U 325 1 N VAL U 321 O VAL U 71
SHEET 4 P 5 VAL U 292 ASP U 296 1 N LEU U 293 O ILE U 320
SHEET 5 P 5 PHE U 98 ALA U 102 1 N THR U 99 O VAL U 292
SHEET 1 Q 3 ALA U 286 PRO U 290 0
SHEET 2 Q 3 ILE U 125 ILE U 136 -1 N LYS U 128 O GLU U 287
SHEET 3 Q 3 GLN U 230 SER U 240 -1 N VAL U 239 O ILE U 127
SHEET 1 R 5 GLU U 166 GLU U 170 0
SHEET 2 R 5 GLY U 156 LYS U 161 -1 N ILE U 160 O THR U 167
SHEET 3 R 5 LEU U 135 ILE U 145 -1 N GLN U 144 O LYS U 157
SHEET 4 R 5 ASP U 188 ASP U 193 -1 N ILE U 192 O ILE U 136
SHEET 5 R 5 ILE U 199 ARG U 204 -1 N GLY U 203 O VAL U 189
SHEET 1 S 5 LEU V 367 ARG V 371 0
SHEET 2 S 5 ALA V 74 ALA V 78 1 N ALA V 74 O LEU V 368
SHEET 3 S 5 VAL V 335 SER V 340 1 N VAL V 336 O ILE V 75
SHEET 4 S 5 VAL V 307 ASP V 311 1 N LEU V 308 O VAL V 335
SHEET 5 S 5 PHE V 102 VAL V 106 1 N CYS V 103 O VAL V 307
SHEET 1 T 3 ASP V 246 THR V 248 0
SHEET 2 T 3 GLY V 130 ARG V 132 -1 N LEU V 131 O VAL V 247
SHEET 3 T 3 GLU V 302 ILE V 304 -1 N ILE V 304 O GLY V 130
SHEET 1 U 4 HIS V 238 ILE V 243 0
SHEET 2 U 4 GLU V 135 GLU V 143 -1 N VAL V 139 O LYS V 239
SHEET 3 U 4 ASP V 198 GLU V 203 -1 N ILE V 202 O TYR V 140
SHEET 4 U 4 VAL V 209 ARG V 214 -1 N GLY V 213 O VAL V 199
SHEET 1 V 3 LEU V 147 PRO V 149 0
SHEET 2 V 3 VAL V 166 VAL V 168 -1 N ILE V 167 O THR V 148
SHEET 3 V 3 LEU V 179 LEU V 181 -1 N LEU V 181 O VAL V 166
SHEET 1 W 2 MET V 344 THR V 346 0
SHEET 2 W 2 ILE V 354 PRO V 356 -1 N SER V 355 O THR V 345
SHEET 1 X 5 SER W 351 ILE W 354 0
SHEET 2 X 5 ALA W 70 ALA W 74 1 N ALA W 70 O ILE W 352
SHEET 3 X 5 ILE W 320 THR W 325 1 N VAL W 321 O VAL W 71
SHEET 4 X 5 VAL W 292 ASP W 296 1 N LEU W 293 O ILE W 320
SHEET 5 X 5 PHE W 98 ALA W 102 1 N THR W 99 O VAL W 292
SHEET 1 Y 3 GLN W 230 SER W 240 0
SHEET 2 Y 3 GLY W 126 ILE W 136 -1 N LEU W 135 O LYS W 231
SHEET 3 Y 3 ALA W 286 VAL W 289 -1 N VAL W 289 O GLY W 126
SHEET 1 Z 5 GLU W 166 LEU W 171 0
SHEET 2 Z 5 GLN W 155 LYS W 161 -1 N ILE W 160 O THR W 167
SHEET 3 Z 5 LEU W 135 ASP W 146 -1 N ASP W 146 O GLN W 155
SHEET 4 Z 5 ASP W 188 ASP W 193 -1 N ILE W 192 O ILE W 136
SHEET 5 Z 5 ILE W 199 ARG W 204 -1 N GLY W 203 O VAL W 189
SHEET 1 AA 5 LEU X 367 ARG X 371 0
SHEET 2 AA 5 ALA X 74 ALA X 78 1 N ALA X 74 O LEU X 368
SHEET 3 AA 5 VAL X 335 SER X 340 1 N VAL X 336 O ILE X 75
SHEET 4 AA 5 VAL X 307 ASP X 311 1 N LEU X 308 O VAL X 335
SHEET 5 AA 5 PHE X 102 VAL X 106 1 N CYS X 103 O VAL X 307
SHEET 1 AB 3 HIS X 238 THR X 248 0
SHEET 2 AB 3 GLY X 130 TYR X 140 -1 N VAL X 139 O LYS X 239
SHEET 3 AB 3 ALA X 301 ILE X 304 -1 N ILE X 304 O GLY X 130
SHEET 1 AC 3 VAL X 139 GLY X 142 0
SHEET 2 AC 3 ASP X 198 GLU X 203 -1 N ILE X 202 O TYR X 140
SHEET 3 AC 3 LYS X 210 ARG X 214 -1 N GLY X 213 O VAL X 199
SHEET 1 AD 3 GLY X 175 ASP X 182 0
SHEET 2 AD 3 ILE X 163 SER X 172 -1 N SER X 172 O GLY X 175
SHEET 3 AD 3 LEU X 147 ASP X 151 -1 N GLU X 150 O SER X 164
SHEET 1 AE 5 ILE Y 353 THR Y 355 0
SHEET 2 AE 5 ALA Y 70 ALA Y 74 1 N LEU Y 72 O ILE Y 354
SHEET 3 AE 5 ILE Y 320 THR Y 325 1 N VAL Y 321 O VAL Y 71
SHEET 4 AE 5 VAL Y 292 ASP Y 296 1 N LEU Y 293 O ILE Y 320
SHEET 5 AE 5 PHE Y 98 ALA Y 102 1 N THR Y 99 O VAL Y 292
SHEET 1 AF 3 GLN Y 230 SER Y 240 0
SHEET 2 AF 3 GLY Y 126 ILE Y 136 -1 N LEU Y 135 O LYS Y 231
SHEET 3 AF 3 ALA Y 286 VAL Y 289 -1 N VAL Y 289 O GLY Y 126
SHEET 1 AG 5 GLU Y 166 GLU Y 170 0
SHEET 2 AG 5 LYS Y 157 LYS Y 161 -1 N ILE Y 160 O THR Y 167
SHEET 3 AG 5 LEU Y 135 ILE Y 143 -1 N GLU Y 142 O THR Y 159
SHEET 4 AG 5 ASP Y 188 ASP Y 193 -1 N ILE Y 192 O ILE Y 136
SHEET 5 AG 5 ILE Y 199 ARG Y 204 -1 N GLY Y 203 O VAL Y 189
LINK SG CYS S 244 ZN ZN S 501 1555 1555 2.66
LINK SG CYS S 247 ZN ZN S 501 1555 1555 2.54
LINK SG CYS S 256 ZN ZN S 502 1555 1555 2.75
LINK SG CYS S 259 ZN ZN S 502 1555 1555 2.49
LINK SG CYS S 264 ZN ZN S 501 1555 1555 2.48
LINK SG CYS S 268 ZN ZN S 501 1555 1555 2.73
LINK NE2 HIS S 272 ZN ZN S 502 1555 1555 2.49
LINK SG CYS S 277 ZN ZN S 502 1555 1555 2.52
LINK OG1 THR U 82 MG MG U 503 1555 1555 2.58
LINK OG1 THR V 86 MG MG V 502 1555 1555 2.42
LINK OE2 GLU W 297 MG MG W 502 1555 1555 2.95
LINK OG1 THR X 86 MG MG X 502 1555 1555 2.47
LINK OG1 THR Y 82 MG MG Y 502 1555 1555 2.08
LINK OD1 ASP Y 296 MG MG Y 502 1555 1555 2.94
LINK OD2 ASP Y 296 MG MG Y 502 1555 1555 2.77
LINK OE2 GLU Y 297 MG MG Y 502 1555 1555 2.92
LINK O1B ADP M1601 BE BEF M1602 1555 1555 1.40
LINK O3B ADP M1601 BE BEF M1602 1555 1555 2.20
LINK O1B ADP R 501 MG MG R 503 1555 1555 2.08
LINK O3B ADP R 501 BE BEF R 502 1555 1555 1.40
LINK O3B ADP T 501 MG MG U 501 1555 1555 2.41
LINK O3B ADP V 501 MG MG V 502 1555 1555 2.76
LINK O3B ADP W 501 MG MG W 502 1555 1555 2.44
LINK O3B ADP X 501 MG MG X 502 1555 1555 2.75
SITE 1 AC1 16 ASN M 695 LEU M 696 GLN M 700 MET M 723
SITE 2 AC1 16 GLY M 724 LEU M 725 GLY M 726 LYS M 727
SITE 3 AC1 16 THR M 728 ILE M 729 ASN M1329 ARG M1354
SITE 4 AC1 16 ARG M1357 ILE M1358 BEF M1602 MG M1603
SITE 1 AC2 6 MET M 723 LYS M 727 ARG M1354 ARG M1357
SITE 2 AC2 6 ADP M1601 MG M1603
SITE 1 AC3 3 ASP M 824 ADP M1601 BEF M1602
SITE 1 AC4 14 GLY R 11 SER R 12 TYR R 13 GLU R 14
SITE 2 AC4 14 LYS R 16 PHE R 195 LYS R 249 GLU R 250
SITE 3 AC4 14 GLY R 358 ASN R 361 LEU R 362 ALA R 393
SITE 4 AC4 14 BEF R 502 MG R 503
SITE 1 AC5 6 SER R 12 GLY R 194 PHE R 195 ASN R 196
SITE 2 AC5 6 ADP R 501 MG R 503
SITE 1 AC6 2 ADP R 501 BEF R 502
SITE 1 AC7 5 CYS S 244 ILE S 246 CYS S 247 CYS S 264
SITE 2 AC7 5 CYS S 268
SITE 1 AC8 4 CYS S 256 CYS S 259 HIS S 272 CYS S 277
SITE 1 AC9 15 ALA T 26 HIS T 29 GLY T 47 PHE T 48
SITE 2 AC9 15 VAL T 49 PRO T 81 SER T 82 GLY T 84
SITE 3 AC9 15 LYS T 85 THR T 86 ALA T 87 TYR T 375
SITE 4 AC9 15 ARG T 413 GLU U 314 MG U 501
SITE 1 AD1 4 THR T 86 ADP T 501 GLU U 314 ARG U 350
SITE 1 AD2 15 ALA U 22 HIS U 25 MET U 44 VAL U 45
SITE 2 AD2 15 PRO U 76 SER U 78 GLY U 80 LYS U 81
SITE 3 AD2 15 THR U 82 ALA U 83 TYR U 359 ILE U 367
SITE 4 AD2 15 ARG U 397 MG U 503 GLU V 329
SITE 1 AD3 3 THR U 82 ASP U 296 ADP U 502
SITE 1 AD4 16 ALA V 26 HIS V 29 GLY V 47 PHE V 48
SITE 2 AD4 16 VAL V 49 GLY V 80 PRO V 81 SER V 82
SITE 3 AD4 16 GLY V 84 LYS V 85 THR V 86 ALA V 87
SITE 4 AD4 16 TYR V 375 ARG V 413 MG V 502 GLU W 314
SITE 1 AD5 2 THR V 86 ADP V 501
SITE 1 AD6 16 ALA W 22 HIS W 25 GLY W 43 MET W 44
SITE 2 AD6 16 VAL W 45 PRO W 77 SER W 78 THR W 79
SITE 3 AD6 16 GLY W 80 LYS W 81 THR W 82 TYR W 359
SITE 4 AD6 16 ARG W 397 MG W 502 GLU X 329 ARG X 366
SITE 1 AD7 3 THR W 82 GLU W 297 ADP W 501
SITE 1 AD8 16 ALA X 26 HIS X 29 GLY X 47 PHE X 48
SITE 2 AD8 16 VAL X 49 GLY X 80 PRO X 81 SER X 82
SITE 3 AD8 16 THR X 83 GLY X 84 LYS X 85 THR X 86
SITE 4 AD8 16 TYR X 375 ILE X 383 ARG X 413 MG X 502
SITE 1 AD9 2 THR X 86 ADP X 501
SITE 1 AE1 17 GLU T 329 ARG T 366 HIS Y 23 HIS Y 25
SITE 2 AE1 17 MET Y 44 VAL Y 45 PRO Y 76 PRO Y 77
SITE 3 AE1 17 SER Y 78 GLY Y 80 LYS Y 81 THR Y 82
SITE 4 AE1 17 ALA Y 83 TYR Y 359 ILE Y 367 ARG Y 397
SITE 5 AE1 17 MG Y 502
SITE 1 AE2 4 THR Y 82 ASP Y 296 GLU Y 297 ADP Y 501
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
